-- dump date 20140619_082322 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_002385499.1 218552586 7125488 190..255 1 NC_011741.1 involved in threonine biosynthesis; controls the expression of the thrLABC operon; thr operon leader peptide 255 thrL 7125488 thrL Escherichia coli IAI1 thr operon leader peptide YP_002385499.1 190 D 585034 CDS YP_002385500.1 218552587 7126255 336..2798 1 NC_011741.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 2798 thrA 7126255 thrA Escherichia coli IAI1 bifunctional aspartokinase I/homoserine dehydrogenase I YP_002385500.1 336 D 585034 CDS YP_002385501.1 218552588 7126252 2800..3732 1 NC_011741.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 3732 thrB 7126252 thrB Escherichia coli IAI1 homoserine kinase YP_002385501.1 2800 D 585034 CDS YP_002385502.1 218552589 7126253 3733..5019 1 NC_011741.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 5019 thrC 7126253 thrC Escherichia coli IAI1 threonine synthase YP_002385502.1 3733 D 585034 CDS YP_002385503.1 218552590 7126254 5233..5529 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5529 yaaX 7126254 yaaX Escherichia coli IAI1 hypothetical protein YP_002385503.1 5233 D 585034 CDS YP_002385504.1 218552591 7126489 complement(5682..6458) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 6458 yaaA 7126489 yaaA Escherichia coli IAI1 hypothetical protein YP_002385504.1 5682 R 585034 CDS YP_002385505.1 218552592 7126484 complement(6528..7958) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino acid sodium/proton transporter 7958 yaaJ 7126484 yaaJ Escherichia coli IAI1 putative amino acid sodium/proton transporter YP_002385505.1 6528 R 585034 CDS YP_002385506.1 218552593 7126487 8237..9190 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8332529, 92334977, 11298760, 7592346, 8805555, 9007983, 9298646; Product type e : enzyme; transaldolase B 9190 talB 7126487 talB Escherichia coli IAI1 transaldolase B YP_002385506.1 8237 D 585034 CDS YP_002385507.1 218552594 7126209 9305..9892 1 NC_011741.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 9892 mogA 7126209 mogA Escherichia coli IAI1 molybdenum cofactor biosynthesis protein MogA YP_002385507.1 9305 D 585034 CDS YP_002385508.1 218552595 7124304 complement(9927..10493) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 10493 yaaH 7124304 yaaH Escherichia coli IAI1 hypothetical protein YP_002385508.1 9927 R 585034 CDS YP_002385509.1 218552596 7126485 complement(10642..11355) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8478327; Product type r : regulator; hypothetical protein 11355 htpY 7126485 htpY Escherichia coli IAI1 hypothetical protein YP_002385509.1 10642 R 585034 CDS YP_002385510.1 218552597 7125320 complement(11381..11785) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 11785 yaaI 7125320 yaaI Escherichia coli IAI1 hypothetical protein YP_002385510.1 11381 R 585034 CDS YP_002385511.1 218552598 7126486 12162..14078 1 NC_011741.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 14078 dnaK 7126486 dnaK Escherichia coli IAI1 molecular chaperone DnaK YP_002385511.1 12162 D 585034 CDS YP_002385512.1 218552599 7127476 14167..15297 1 NC_011741.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 15297 dnaJ 7127476 dnaJ Escherichia coli IAI1 chaperone protein DnaJ YP_002385512.1 14167 D 585034 CDS YP_002385513.1 218552600 7124609 complement(15401..15610) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90136075, 92048480, 92048481, 99291074; Product type r : regulator; regulatory protein for HokC, overlaps CDS of hokC 15610 mokC 7124609 mokC Escherichia coli IAI1 regulatory protein for HokC, overlaps CDS of hokC YP_002385513.1 15401 R 585034 CDS YP_002385514.1 218552601 7127947 16139..17305 1 NC_011741.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 17305 nhaA 7127947 nhaA Escherichia coli IAI1 pH-dependent sodium/proton antiporter YP_002385514.1 16139 D 585034 CDS YP_002385515.1 218552602 7127873 17365..18270 1 NC_011741.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 18270 nhaR 7127873 nhaR Escherichia coli IAI1 transcriptional activator NhaR YP_002385515.1 17365 D 585034 CDS YP_002385516.1 218552603 7127875 complement(18309..19268) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 19268 7127875 ECIAI1_0019 Escherichia coli IAI1 hypothetical protein YP_002385516.1 18309 R 585034 CDS YP_002385517.1 218552604 7126970 complement(19281..19592) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 19592 7126970 ECIAI1_0020 Escherichia coli IAI1 hypothetical protein YP_002385517.1 19281 R 585034 CDS YP_002385518.1 218552605 7126971 complement(20175..20426) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 20426 7126971 ECIAI1_0021 Escherichia coli IAI1 hypothetical protein YP_002385518.1 20175 R 585034 CDS YP_002385519.1 218552606 7126972 complement(20859..22280) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 22280 7126972 ECIAI1_0022 Escherichia coli IAI1 hypothetical protein YP_002385519.1 20859 R 585034 CDS YP_002385520.1 218552607 7126973 complement(22764..23027) 1 NC_011741.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 23027 rpsT 7126973 rpsT Escherichia coli IAI1 30S ribosomal protein S20 YP_002385520.1 22764 R 585034 CDS YP_002385521.1 218552608 7128426 23130..23348 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 23348 yaaY 7128426 yaaY Escherichia coli IAI1 hypothetical protein YP_002385521.1 23130 D 585034 CDS YP_002385522.1 218552609 7126490 23356..24297 1 NC_011741.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 24297 ribF 7126490 ribF Escherichia coli IAI1 bifunctional riboflavin kinase/FMN adenylyltransferase YP_002385522.1 23356 D 585034 CDS YP_002385523.1 218552610 7124997 24340..27156 1 NC_011741.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 27156 ileS 7124997 ileS Escherichia coli IAI1 isoleucyl-tRNA synthetase YP_002385523.1 24340 D 585034 CDS YP_002385524.1 218552611 7126049 27156..27650 1 NC_011741.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 27650 lspA 7126049 lspA Escherichia coli IAI1 lipoprotein signal peptidase YP_002385524.1 27156 D 585034 CDS YP_002385525.1 218552612 7127632 27738..28187 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97332650, 2011499; Product type e : enzyme; FKBP-type peptidyl-prolyl cis-trans isomerase 28187 fkpB 7127632 fkpB Escherichia coli IAI1 FKBP-type peptidyl-prolyl cis-trans isomerase YP_002385525.1 27738 D 585034 CDS YP_002385526.1 218552613 7127208 28189..29139 1 NC_011741.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 29139 ispH 7127208 ispH Escherichia coli IAI1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_002385526.1 28189 D 585034 CDS YP_002385527.1 218552614 7126085 29205..30119 1 NC_011741.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 30119 rihC 7126085 rihC Escherichia coli IAI1 ribonucleoside hydrolase RihC YP_002385527.1 29205 D 585034 CDS YP_002385528.1 218552615 7125000 30286..31107 1 NC_011741.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 31107 dapB 7125000 dapB Escherichia coli IAI1 dihydrodipicolinate reductase YP_002385528.1 30286 D 585034 CDS YP_002385529.1 218552616 7126917 31563..32711 1 NC_011741.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 32711 carA 7126917 carA Escherichia coli IAI1 carbamoyl phosphate synthase small subunit YP_002385529.1 31563 D 585034 CDS YP_002385530.1 218552617 7124448 32729..35950 1 NC_011741.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 35950 carB 7124448 carB Escherichia coli IAI1 carbamoyl phosphate synthase large subunit YP_002385530.1 32729 D 585034 CDS YP_002385531.1 218552618 7124449 complement(35958..36176) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7815937, 6308632; hypothetical protein 36176 7124449 ECIAI1_0035 Escherichia coli IAI1 hypothetical protein YP_002385531.1 35958 R 585034 CDS YP_002385532.1 218552619 7126974 36211..36606 1 NC_011741.1 regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; DNA-binding transcriptional activator CaiF 36606 caiF 7126974 caiF Escherichia coli IAI1 DNA-binding transcriptional activator CaiF YP_002385532.1 36211 D 585034 CDS YP_002385533.1 218552620 7124445 complement(36692..37282) 1 NC_011741.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE 37282 caiE 7124445 caiE Escherichia coli IAI1 carnitine operon protein CaiE YP_002385533.1 36692 R 585034 CDS YP_002385534.2 229598863 7124444 complement(37288..38073) 1 NC_011741.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase 38073 caiD 7124444 caiD Escherichia coli IAI1 carnitinyl-CoA dehydratase YP_002385534.2 37288 R 585034 CDS YP_002385535.1 218552622 7124443 complement(38182..39750) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15731894, 97189569, 7815937; Product type e : enzyme; putative crotonobetaine/carnitine-CoA ligase 39750 caiC 7124443 caiC Escherichia coli IAI1 putative crotonobetaine/carnitine-CoA ligase YP_002385535.1 38182 R 585034 CDS YP_002385536.1 218552623 7124442 complement(39809..41026) 1 NC_011741.1 catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine; crotonobetainyl-CoA:carnitine CoA-transferase 41026 caiB 7124442 caiB Escherichia coli IAI1 crotonobetainyl-CoA:carnitine CoA-transferase YP_002385536.1 39809 R 585034 CDS YP_002385537.1 218552624 7124441 complement(41155..42297) 1 NC_011741.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase 42297 caiA 7124441 caiA Escherichia coli IAI1 crotonobetainyl-CoA dehydrogenase YP_002385537.1 41155 R 585034 CDS YP_002385538.1 218552625 7124440 complement(42328..43842) 1 NC_011741.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter 43842 caiT 7124440 caiT Escherichia coli IAI1 L-carnitine/gamma-butyrobetaine antiporter YP_002385538.1 42328 R 585034 CDS YP_002385539.1 218552626 7124446 44316..45086 1 NC_011741.1 required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; putative electron transfer flavoprotein FixA 45086 fixA 7124446 fixA Escherichia coli IAI1 putative electron transfer flavoprotein FixA YP_002385539.1 44316 D 585034 CDS YP_002385540.1 218552627 7127122 45101..46042 1 NC_011741.1 involved in electron transfer during carnitine metabolism; putative electron transfer flavoprotein FixB 46042 fixB 7127122 fixB Escherichia coli IAI1 putative electron transfer flavoprotein FixB YP_002385540.1 45101 D 585034 CDS YP_002385541.1 218552628 7127123 46093..47379 1 NC_011741.1 FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; putative oxidoreductase FixC 47379 fixC 7127123 fixC Escherichia coli IAI1 putative oxidoreductase FixC YP_002385541.1 46093 D 585034 CDS YP_002385542.1 218552629 7127124 47376..47663 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96066354, 12081978; Product type pc : putative carrier; putative 4Fe-4S ferredoxin 47663 fixX 7127124 fixX Escherichia coli IAI1 putative 4Fe-4S ferredoxin YP_002385542.1 47376 D 585034 CDS YP_002385543.1 218552630 7127125 47721..49052 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 49052 yaaU 7127125 yaaU Escherichia coli IAI1 putative transporter YP_002385543.1 47721 D 585034 CDS YP_002385544.1 218552631 7126488 49160..49690 1 NC_011741.1 Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 49690 kefF 7126488 kefF Escherichia coli IAI1 glutathione-regulated potassium-efflux system ancillary protein KefF YP_002385544.1 49160 D 585034 CDS YP_002385545.1 218552632 7126388 49683..51545 1 NC_011741.1 transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 51545 kefC 7126388 kefC Escherichia coli IAI1 glutathione-regulated potassium-efflux system protein KefC YP_002385545.1 49683 D 585034 CDS YP_002385546.1 218552633 7126387 51737..52216 1 NC_011741.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 52216 folA 7126387 folA Escherichia coli IAI1 dihydrofolate reductase YP_002385546.1 51737 D 585034 CDS YP_002385547.1 218552634 7127259 complement(52294..53136) 1 NC_011741.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 53136 apaH 7127259 apaH Escherichia coli IAI1 diadenosine tetraphosphatase YP_002385547.1 52294 R 585034 CDS YP_002385548.1 218552635 7125768 complement(53143..53520) 1 NC_011741.1 protein associated with Co2+ and Mg2+ efflux; ApaG protein 53520 apaG 7125768 apaG Escherichia coli IAI1 ApaG protein YP_002385548.1 53143 R 585034 CDS YP_002385549.1 218552636 7125767 complement(53523..54344) 1 NC_011741.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 54344 ksgA 7125767 ksgA Escherichia coli IAI1 dimethyladenosine transferase YP_002385549.1 53523 R 585034 CDS YP_002385550.1 218552637 7126392 complement(54341..55330) 1 NC_011741.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase 55330 pdxA 7126392 pdxA Escherichia coli IAI1 4-hydroxythreonine-4-phosphate dehydrogenase YP_002385550.1 54341 R 585034 CDS YP_002385551.1 218552638 7124163 complement(55330..56616) 1 NC_011741.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA 56616 surA 7124163 surA Escherichia coli IAI1 peptidyl-prolyl cis-trans isomerase SurA YP_002385551.1 55330 R 585034 CDS YP_002385552.1 218552639 7126202 complement(56669..59023) 1 NC_011741.1 determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein 59023 imp 7126202 imp Escherichia coli IAI1 organic solvent tolerance protein YP_002385552.1 56669 R 585034 CDS YP_002385553.1 218552640 7126062 59278..60093 1 NC_011741.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 60093 djlA 7126062 djlA Escherichia coli IAI1 Dna-J like membrane chaperone protein YP_002385553.1 59278 D 585034 CDS YP_002385554.1 218552641 7124593 complement(60210..60869) 1 NC_011741.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A 60869 rluA 7124593 rluA Escherichia coli IAI1 23S rRNA/tRNA pseudouridine synthase A YP_002385554.1 60210 R 585034 CDS YP_002385555.1 218552642 7125009 complement(60881..63787) 1 NC_011741.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA 63787 hepA 7125009 hepA Escherichia coli IAI1 ATP-dependent helicase HepA YP_002385555.1 60881 R 585034 CDS YP_002385556.1 218552643 7128517 complement(63952..66303) 1 NC_011741.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II 66303 polB 7128517 polB Escherichia coli IAI1 DNA polymerase II YP_002385556.1 63952 R 585034 CDS YP_002385557.1 218552644 7126112 complement(66378..67073) 1 NC_011741.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 67073 araD 7126112 araD Escherichia coli IAI1 L-ribulose-5-phosphate 4-epimerase YP_002385557.1 66378 R 585034 CDS YP_002385558.1 218552645 7125778 complement(67242..68744) 1 NC_011741.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase 68744 araA 7125778 araA Escherichia coli IAI1 L-arabinose isomerase YP_002385558.1 67242 R 585034 CDS YP_002385559.1 218552646 7125775 complement(68755..70455) 1 NC_011741.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase 70455 araB 7125775 araB Escherichia coli IAI1 ribulokinase YP_002385559.1 68755 R 585034 CDS YP_002385560.1 218552647 7125776 70794..71672 1 NC_011741.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; DNA-binding transcriptional regulator AraC 71672 araC 7125776 araC Escherichia coli IAI1 DNA-binding transcriptional regulator AraC YP_002385560.1 70794 D 585034 CDS YP_002385561.1 218552648 7125777 71758..72522 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 72522 yabI 7125777 yabI Escherichia coli IAI1 hypothetical protein YP_002385561.1 71758 D 585034 CDS YP_002385562.1 218552649 7126491 complement(72636..73334) 1 NC_011741.1 with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding subunit 73334 thiQ 7126491 thiQ Escherichia coli IAI1 thiamine transporter ATP-binding subunit YP_002385562.1 72636 R 585034 CDS YP_002385563.1 218552650 7126250 complement(73318..74928) 1 NC_011741.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein 74928 thiP 7126250 thiP Escherichia coli IAI1 thiamine transporter membrane protein YP_002385563.1 73318 R 585034 CDS YP_002385564.1 218552651 7126249 complement(74904..75887) 1 NC_011741.1 part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit 75887 tbpA 7126249 tbpA Escherichia coli IAI1 thiamine transporter substrate binding subunit YP_002385564.1 74904 R 585034 CDS YP_002385565.1 218552652 7125492 complement(76051..77706) 1 NC_011741.1 activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR 77706 sgrR 7125492 sgrR Escherichia coli IAI1 transcriptional regulator SgrR YP_002385565.1 76051 R 585034 CDS YP_002385566.1 218552653 7127926 77627..77926 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 77926 7127926 ECIAI1_0070 Escherichia coli IAI1 hypothetical protein YP_002385566.1 77627 D 585034 CDS YP_002385567.1 218552654 7127927 78028..79206 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438463, 10209755; Product type t : transporter; broad specificity sugar efflux system 79206 setA 7127927 setA Escherichia coli IAI1 broad specificity sugar efflux system YP_002385567.1 78028 D 585034 CDS YP_002385568.1 218552655 7127912 complement(79255..79860) 1 NC_011741.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 79860 leuD 7127912 leuD Escherichia coli IAI1 isopropylmalate isomerase small subunit YP_002385568.1 79255 R 585034 CDS YP_002385569.1 218552656 7126410 complement(79871..81271) 1 NC_011741.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 81271 leuC 7126410 leuC Escherichia coli IAI1 isopropylmalate isomerase large subunit YP_002385569.1 79871 R 585034 CDS YP_002385570.1 218552657 7126409 complement(81274..82365) 1 NC_011741.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 82365 leuB 7126409 leuB Escherichia coli IAI1 3-isopropylmalate dehydrogenase YP_002385570.1 81274 R 585034 CDS YP_002385571.1 218552658 7126408 complement(82365..83936) 1 NC_011741.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 83936 leuA 7126408 leuA Escherichia coli IAI1 2-isopropylmalate synthase YP_002385571.1 82365 R 585034 CDS YP_002385572.1 218552659 7125499 complement(84029..84115) 1 NC_011741.1 involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide 84115 leuL 7125499 leuL Escherichia coli IAI1 leu operon leader peptide YP_002385572.1 84029 R 585034 CDS YP_002385573.1 218552660 7126411 84775..85719 1 NC_011741.1 activator for leuABCD operon; member of LysR family of transcriptional activators; leucine transcriptional activator 85719 leuO 7126411 leuO Escherichia coli IAI1 leucine transcriptional activator YP_002385573.1 84775 D 585034 CDS YP_002385574.1 218552661 7126412 86037..87761 1 NC_011741.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 87761 ilvI 7126412 ilvI Escherichia coli IAI1 acetolactate synthase 3 catalytic subunit YP_002385574.1 86037 D 585034 CDS YP_002385575.1 218552662 7126057 87764..88255 1 NC_011741.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 88255 ilvH 7126057 ilvH Escherichia coli IAI1 acetolactate synthase 3 regulatory subunit YP_002385575.1 87764 D 585034 CDS YP_002385576.1 218552663 7126056 88435..89439 1 NC_011741.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 89439 fruR 7126056 fruR Escherichia coli IAI1 DNA-binding transcriptional regulator FruR YP_002385576.1 88435 D 585034 CDS YP_002385577.1 218552664 7128220 90041..90499 1 NC_011741.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 90499 mraZ 7128220 mraZ Escherichia coli IAI1 cell division protein MraZ YP_002385577.1 90041 D 585034 CDS YP_002385578.1 218552665 7124469 90501..91442 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20042184, 10493123, 2187182, 6350821; Product type e : enzyme; S-adenosyl-methyltransferase MraW 91442 mraW 7124469 mraW Escherichia coli IAI1 S-adenosyl-methyltransferase MraW YP_002385578.1 90501 D 585034 CDS YP_002385579.1 218552666 7124467 91439..91804 1 NC_011741.1 membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 91804 ftsL 7124467 ftsL Escherichia coli IAI1 cell division protein FtsL YP_002385579.1 91439 D 585034 CDS YP_002385580.1 218552667 7128238 91820..93586 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91072213, 92202178, 94095121, 9603865, 9614966, 1332942, 1447153, 2198024, 2677607, 2681146, 3049550, 3911028, 6350821; Product type e : enzyme; septal peptidoglycan synthesis transpeptidase 93586 ftsI 7128238 ftsI Escherichia coli IAI1 septal peptidoglycan synthesis transpeptidase YP_002385580.1 91820 D 585034 CDS YP_002385581.1 218552668 7128236 93573..95060 1 NC_011741.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 95060 murE 7128236 murE Escherichia coli IAI1 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_002385581.1 93573 D 585034 CDS YP_002385582.1 218552669 7124496 95057..96415 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88273095, 90248455, 91310568, 97128642, 11090285, 2668880, 9166795; Product type e : enzyme; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 96415 murF 7124496 murF Escherichia coli IAI1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase YP_002385582.1 95057 D 585034 CDS YP_002385583.1 218552670 7124497 96409..97491 1 NC_011741.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 97491 mraY 7124497 mraY Escherichia coli IAI1 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_002385583.1 96409 D 585034 CDS YP_002385584.1 218552671 7124468 97494..98810 1 NC_011741.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 98810 murD 7124468 murD Escherichia coli IAI1 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_002385584.1 97494 D 585034 CDS YP_002385585.1 218552672 7124495 98810..100054 1 NC_011741.1 integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 100054 ftsW 7124495 ftsW Escherichia coli IAI1 cell division protein FtsW YP_002385585.1 98810 D 585034 CDS YP_002385586.1 218552673 7128241 100051..101118 1 NC_011741.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 101118 murG 7128241 murG Escherichia coli IAI1 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_002385586.1 100051 D 585034 CDS YP_002385587.1 218552674 7124498 101172..102647 1 NC_011741.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 102647 murC 7124498 murC Escherichia coli IAI1 UDP-N-acetylmuramate--L-alanine ligase YP_002385587.1 101172 D 585034 CDS YP_002385588.1 218552675 7124494 102640..103560 1 NC_011741.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 103560 ddl 7124494 ddl Escherichia coli IAI1 D-alanine--D-alanine ligase YP_002385588.1 102640 D 585034 CDS YP_002385589.1 218552676 7124549 103562..104392 1 NC_011741.1 involved in septum formation; cell division protein FtsQ 104392 ftsQ 7124549 ftsQ Escherichia coli IAI1 cell division protein FtsQ YP_002385589.1 103562 D 585034 CDS YP_002385590.1 218552677 7128240 104389..105651 1 NC_011741.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 105651 ftsA 7128240 ftsA Escherichia coli IAI1 cell division protein FtsA YP_002385590.1 104389 D 585034 CDS YP_002385591.1 218552678 7128232 105712..106863 1 NC_011741.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 106863 ftsZ 7128232 ftsZ Escherichia coli IAI1 cell division protein FtsZ YP_002385591.1 105712 D 585034 CDS YP_002385592.1 218552679 7128244 106964..107881 1 NC_011741.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 107881 lpxC 7128244 lpxC Escherichia coli IAI1 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_002385592.1 106964 D 585034 CDS YP_002385593.1 218552680 7127624 108112..108624 1 NC_011741.1 secM translational pause allows for the initiation of secA translation; SecA regulator SecM 108624 secM 7127624 secM Escherichia coli IAI1 SecA regulator SecM YP_002385593.1 108112 D 585034 CDS YP_002385594.1 218552681 7124697 108686..111391 1 NC_011741.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 111391 secA 7124697 secA Escherichia coli IAI1 preprotein translocase subunit SecA YP_002385594.1 108686 D 585034 CDS YP_002385595.1 218552682 7124691 111451..111840 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10218109, 89264540, 90136514, 91225007, 97444511, 1309939, 2841285, 3033442, 3288626, 7578113, 9063868; Product type e : enzyme; nucleoside triphosphate pyrophosphohydrolase 111840 mutT 7124691 mutT Escherichia coli IAI1 nucleoside triphosphate pyrophosphohydrolase YP_002385595.1 111451 D 585034 CDS YP_002385596.1 218552683 7124506 complement(112147..112890) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 112890 yacF 7124506 yacF Escherichia coli IAI1 hypothetical protein YP_002385596.1 112147 R 585034 CDS YP_002385597.1 218552684 7126493 complement(112890..113510) 1 NC_011741.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 113510 coaE 7126493 coaE Escherichia coli IAI1 dephospho-CoA kinase YP_002385597.1 112890 R 585034 CDS YP_002385598.1 218552685 7126344 113735..114778 1 NC_011741.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 114778 guaC 7126344 guaC Escherichia coli IAI1 guanosine 5'-monophosphate oxidoreductase YP_002385598.1 113735 D 585034 CDS YP_002385599.1 218552686 7128478 complement(114813..116015) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96099298, 2904262, 7959070; Product type s : structure; type IV pilin biogenesis protein 116015 hofC 7128478 hofC Escherichia coli IAI1 type IV pilin biogenesis protein YP_002385599.1 114813 R 585034 CDS YP_002385600.1 218552687 7125288 complement(116005..117390) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96099298, 7959070; Product type pt : putative transporter; hypothetical protein 117390 hofB 7125288 hofB Escherichia coli IAI1 hypothetical protein YP_002385600.1 116005 R 585034 CDS YP_002385601.1 218552688 7125287 complement(117400..117840) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20100782, 20271862, 96099298, 7959070; Product type ps : putative structure; putative major pilin subunit 117840 ppdD 7125287 ppdD Escherichia coli IAI1 putative major pilin subunit YP_002385601.1 117400 R 585034 CDS YP_002385602.1 218552689 7126129 complement(118043..118936) 1 NC_011741.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase 118936 nadC 7126129 nadC Escherichia coli IAI1 quinolinate phosphoribosyltransferase YP_002385602.1 118043 R 585034 CDS YP_002385603.1 218552690 7124513 119024..119575 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90113890, 95047240, 2607970, 7959070; Product type e : enzyme; N-acetyl-anhydromuranmyl-L-alanine amidase 119575 ampD 7124513 ampD Escherichia coli IAI1 N-acetyl-anhydromuranmyl-L-alanine amidase YP_002385603.1 119024 D 585034 CDS YP_002385604.1 218552691 7125757 119572..120426 1 NC_011741.1 involved in regulation of beta-lactamase; putative signaling protein; regulatory protein AmpE 120426 ampE 7125757 ampE Escherichia coli IAI1 regulatory protein AmpE YP_002385604.1 119572 D 585034 CDS YP_002385605.1 218552692 7125758 complement(120469..121842) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1104763, 90174991, 9150230; Product type t : transporter; aromatic amino acid transporter 121842 aroP 7125758 aroP Escherichia coli IAI1 aromatic amino acid transporter YP_002385605.1 120469 R 585034 CDS YP_002385606.1 218552693 7125813 122383..123147 1 NC_011741.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 123147 pdhR 7125813 pdhR Escherichia coli IAI1 transcriptional regulator PdhR YP_002385606.1 122383 D 585034 CDS YP_002385607.1 218552694 7127474 complement(123144..123326) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 123326 7127474 ECIAI1_0111 Escherichia coli IAI1 hypothetical protein YP_002385607.1 123144 R 585034 CDS YP_002385608.1 218552695 7126976 123308..125971 1 NC_011741.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 125971 aceE 7126976 aceE Escherichia coli IAI1 pyruvate dehydrogenase subunit E1 YP_002385608.1 123308 D 585034 CDS YP_002385609.1 218552696 7125696 125986..127878 1 NC_011741.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 127878 aceF 7125696 aceF Escherichia coli IAI1 dihydrolipoamide acetyltransferase YP_002385609.1 125986 D 585034 CDS YP_002385610.1 218552697 7125697 128203..129627 1 NC_011741.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 129627 lpd 7125697 lpd Escherichia coli IAI1 dihydrolipoamide dehydrogenase YP_002385610.1 128203 D 585034 CDS YP_002385611.1 218552698 7126440 complement(129698..131455) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 131455 yacH 7126440 yacH Escherichia coli IAI1 hypothetical protein YP_002385611.1 129698 R 585034 CDS YP_002385612.1 218552699 7126494 131810..134407 1 NC_011741.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 134407 acnB 7126494 acnB Escherichia coli IAI1 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase YP_002385612.1 131810 D 585034 CDS YP_002385613.1 218552700 7125701 134583..134945 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2666401, 7567469; hypothetical protein 134945 yacL 7125701 yacL Escherichia coli IAI1 hypothetical protein YP_002385613.1 134583 D 585034 CDS YP_002385614.1 218552701 7126495 complement(134983..135777) 1 NC_011741.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase 135777 speD 7126495 speD Escherichia coli IAI1 S-adenosylmethionine decarboxylase YP_002385614.1 134983 R 585034 CDS YP_002385615.1 218552702 7127957 complement(135793..136659) 1 NC_011741.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 136659 speE 7127957 speE Escherichia coli IAI1 spermidine synthase YP_002385615.1 135793 R 585034 CDS YP_002385616.1 218552703 7127958 complement(136765..137283) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2666401; hypothetical protein 137283 yacC 7127958 yacC Escherichia coli IAI1 hypothetical protein YP_002385616.1 136765 R 585034 CDS YP_002385617.1 218552704 7126492 137278..138828 1 NC_011741.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 138828 cueO 7126492 cueO Escherichia coli IAI1 multicopper oxidase YP_002385617.1 137278 D 585034 CDS YP_002385618.1 218552705 7126857 complement(139030..141420) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10359647, 11604400, 14612441, 91035240, 93123180, 93286127; Product type e : enzyme; glucose dehydrogenase 141420 gcd 7126857 gcd Escherichia coli IAI1 glucose dehydrogenase YP_002385618.1 139030 R 585034 CDS YP_002385619.1 218552706 7128291 141626..142162 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 13808016, 339828, 6787390, 6801015, 12070315; Product type e : enzyme; hypoxanthine phosphoribosyltransferase 142162 hpt 7128291 hpt Escherichia coli IAI1 hypoxanthine phosphoribosyltransferase YP_002385619.1 141626 D 585034 CDS YP_002385620.1 218552707 7125306 complement(142203..142865) 1 NC_011741.1 catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase 142865 can 7125306 can Escherichia coli IAI1 carbonic anhydrase YP_002385620.1 142203 R 585034 CDS YP_002385621.1 218552708 7124447 142974..143900 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 143900 yadG 7124447 yadG Escherichia coli IAI1 putative ABC transporter ATP-binding protein YP_002385621.1 142974 D 585034 CDS YP_002385622.1 218552709 7126499 143897..144667 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10474187; Product type pt : putative transporter; putative ABC transporter membrane protein 144667 yadH 7126499 yadH Escherichia coli IAI1 putative ABC transporter membrane protein YP_002385622.1 143897 D 585034 CDS YP_002385623.1 218552710 7126500 144772..145212 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative PTS Enzyme IIA 145212 yadI 7126500 yadI Escherichia coli IAI1 putative PTS Enzyme IIA YP_002385623.1 144772 D 585034 CDS YP_002385624.1 218552711 7126501 145276..146505 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported polysaccharide deacetylase 146505 yadE 7126501 yadE Escherichia coli IAI1 putative exported polysaccharide deacetylase YP_002385624.1 145276 D 585034 CDS YP_002385625.1 218552712 7126498 complement(146509..146889) 1 NC_011741.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 146889 panD 7126498 panD Escherichia coli IAI1 aspartate alpha-decarboxylase YP_002385625.1 146509 R 585034 CDS YP_002385626.1 218552713 7124152 147163..148065 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11319082; Product type pe : putative enzyme; putative transposase 148065 yadD 7124152 yadD Escherichia coli IAI1 putative transposase YP_002385626.1 147163 D 585034 CDS YP_002385627.1 218552714 7126497 complement(148139..148990) 1 NC_011741.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 148990 panC 7126497 panC Escherichia coli IAI1 pantoate--beta-alanine ligase YP_002385627.1 148139 R 585034 CDS YP_002385628.1 218552715 7124151 complement(149002..149796) 1 NC_011741.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 149796 panB 7124151 panB Escherichia coli IAI1 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_002385628.1 149002 R 585034 CDS YP_002385629.1 218552716 7124150 complement(149909..151255) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8096212; Product type ps : putative structure; putative fimbrial-like adhesin protein 151255 7124150 ECIAI1_0133 Escherichia coli IAI1 putative fimbrial-like adhesin protein YP_002385629.1 149909 R 585034 CDS YP_002385630.1 218552717 7126977 complement(151236..151832) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein 151832 yadK 7126977 yadK Escherichia coli IAI1 putative fimbrial-like adhesin protein YP_002385630.1 151236 R 585034 CDS YP_002385631.1 218552718 7126502 complement(151859..152461) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein 152461 yadL 7126502 yadL Escherichia coli IAI1 putative fimbrial-like adhesin protein YP_002385631.1 151859 R 585034 CDS YP_002385632.1 218552719 7126503 complement(152476..153045) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein 153045 yadM 7126503 yadM Escherichia coli IAI1 putative fimbrial-like adhesin exported protein YP_002385632.1 152476 R 585034 CDS YP_002385633.1 218552720 7126504 complement(153062..155662) 1 NC_011741.1 similar to the fimbrial usher protein PapC; putative outer membrane usher protein 155662 htrE 7126504 htrE Escherichia coli IAI1 putative outer membrane usher protein YP_002385633.1 153062 R 585034 CDS YP_002385634.1 218552721 7125322 complement(155697..156437) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 93352405, 8102362, 15561151; Product type f : factor; putative chaperone protein EcpD 156437 ecpD 7125322 ecpD Escherichia coli IAI1 putative chaperone protein EcpD YP_002385634.1 155697 R 585034 CDS YP_002385635.1 218552722 7125047 complement(156542..157126) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein 157126 yadN 7125047 yadN Escherichia coli IAI1 putative fimbrial-like adhesin exported protein YP_002385635.1 156542 R 585034 CDS YP_002385636.1 218552723 7126505 complement(157496..157975) 1 NC_011741.1 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase 157975 folK 7126505 folK Escherichia coli IAI1 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase YP_002385636.1 157496 R 585034 CDS YP_002385637.1 218552724 7127264 complement(157972..159390) 1 NC_011741.1 Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase I 159390 pcnB 7127264 pcnB Escherichia coli IAI1 poly(A) polymerase I YP_002385637.1 157972 R 585034 CDS YP_002385638.1 218552725 7124161 complement(159429..160355) 1 NC_011741.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase 160355 yadB 7124161 yadB Escherichia coli IAI1 glutamyl-Q tRNA(Asp) synthetase YP_002385638.1 159429 R 585034 CDS YP_002385639.1 218552726 7126496 complement(160392..160847) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15294157, 90202727, 2013578, 9298646, 9600841; Product type r : regulator; RNA polymerase-binding transcription factor 160847 dksA 7126496 dksA Escherichia coli IAI1 RNA polymerase-binding transcription factor YP_002385639.1 160392 R 585034 CDS YP_002385640.1 218552727 7124598 complement(161025..161729) 1 NC_011741.1 Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A 161729 sfsA 7124598 sfsA Escherichia coli IAI1 sugar fermentation stimulation protein A YP_002385640.1 161025 R 585034 CDS YP_002385641.1 218552728 7127921 complement(161744..162274) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97094878; Product type e : enzyme; 2'-5' RNA ligase 162274 ligT 7127921 ligT Escherichia coli IAI1 2'-5' RNA ligase YP_002385641.1 161744 R 585034 CDS YP_002385642.1 218552729 7126420 162348..164777 1 NC_011741.1 similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 164777 hrpB 7126420 hrpB Escherichia coli IAI1 ATP-dependent RNA helicase HrpB YP_002385642.1 162348 D 585034 CDS YP_002385643.1 218552730 7125308 164973..167507 1 NC_011741.1 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 167507 mrcB 7125308 mrcB Escherichia coli IAI1 penicillin-binding protein 1b YP_002385643.1 164973 D 585034 CDS YP_002385644.1 218552731 7124471 167727..169970 1 NC_011741.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 169970 fhuA 7124471 fhuA Escherichia coli IAI1 ferrichrome outer membrane transporter YP_002385644.1 167727 D 585034 CDS YP_002385645.1 218552732 7127098 170021..170818 1 NC_011741.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding subunit 170818 fhuC 7127098 fhuC Escherichia coli IAI1 iron-hydroxamate transporter ATP-binding subunit YP_002385645.1 170021 D 585034 CDS YP_002385646.1 218552733 7127100 170818..171708 1 NC_011741.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 171708 fhuD 7127100 fhuD Escherichia coli IAI1 iron-hydroxamate transporter substrate-binding subunit YP_002385646.1 170818 D 585034 CDS YP_002385647.1 218552734 7127101 171705..173687 1 NC_011741.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 173687 fhuB 7127101 fhuB Escherichia coli IAI1 iron-hydroxamate transporter permease subunit YP_002385647.1 171705 D 585034 CDS YP_002385648.1 218552735 7127099 complement(173722..175002) 1 NC_011741.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 175002 hemL 7127099 hemL Escherichia coli IAI1 glutamate-1-semialdehyde aminotransferase YP_002385648.1 173722 R 585034 CDS YP_002385649.1 218552736 7128513 175227..176648 1 NC_011741.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 176648 clcA 7128513 clcA Escherichia coli IAI1 chloride channel protein YP_002385649.1 175227 D 585034 CDS YP_002385650.1 218552737 7126329 176730..177074 1 NC_011741.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 177074 yadR 7126329 yadR Escherichia coli IAI1 iron-sulfur cluster insertion protein ErpA YP_002385650.1 176730 D 585034 CDS YP_002385651.1 218552738 7126506 complement(177121..177744) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 177744 yadS 7126506 yadS Escherichia coli IAI1 hypothetical protein YP_002385651.1 177121 R 585034 CDS YP_002385652.1 218552739 7126507 complement(177782..178582) 1 NC_011741.1 solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF 178582 btuF 7126507 btuF Escherichia coli IAI1 vitamin B12-transporter protein BtuF YP_002385652.1 177782 R 585034 CDS YP_002385653.1 218552740 7124427 complement(178575..179273) 1 NC_011741.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 179273 pfs 7124427 pfs Escherichia coli IAI1 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_002385653.1 178575 R 585034 CDS YP_002385654.1 218552741 7124184 179357..180874 1 NC_011741.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 180874 dgt 7124184 dgt Escherichia coli IAI1 deoxyguanosinetriphosphate triphosphohydrolase YP_002385654.1 179357 D 585034 CDS YP_002385655.1 218552742 7124578 181004..182428 1 NC_011741.1 protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 182428 degP 7124578 degP Escherichia coli IAI1 serine endoprotease YP_002385655.1 181004 D 585034 CDS YP_002385656.1 218552743 7124560 182583..183740 1 NC_011741.1 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization; carbohydrate diacid transcriptional activator CdaR 183740 cdaR 7124560 cdaR Escherichia coli IAI1 carbohydrate diacid transcriptional activator CdaR YP_002385656.1 182583 D 585034 CDS YP_002385657.1 218552744 7126294 complement(183829..184215) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 184215 yaeH 7126294 yaeH Escherichia coli IAI1 hypothetical protein YP_002385657.1 183829 R 585034 CDS YP_002385658.1 218552745 7126511 complement(184530..185354) 1 NC_011741.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 185354 dapD 7126511 dapD Escherichia coli IAI1 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase YP_002385658.1 184530 R 585034 CDS YP_002385659.1 218552746 7126918 complement(185385..188057) 1 NC_011741.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase 188057 glnD 7126918 glnD Escherichia coli IAI1 PII uridylyl-transferase YP_002385659.1 185385 R 585034 CDS YP_002385660.1 218552747 7128323 complement(188119..188913) 1 NC_011741.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 188913 map 7128323 map Escherichia coli IAI1 methionine aminopeptidase YP_002385660.1 188119 R 585034 CDS YP_002385661.1 218552748 7127672 complement(188913..189134) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 189134 7127672 ECIAI1_0166 Escherichia coli IAI1 hypothetical protein YP_002385661.1 188913 R 585034 CDS YP_002385662.1 218552749 7126205 189281..190006 1 NC_011741.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 190006 rpsB 7126205 rpsB Escherichia coli IAI1 30S ribosomal protein S2 YP_002385662.1 189281 D 585034 CDS YP_002385663.1 218552750 7128408 190264..191115 1 NC_011741.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 191115 tsf 7128408 tsf Escherichia coli IAI1 elongation factor Ts YP_002385663.1 190264 D 585034 CDS YP_002385664.1 218552751 7127509 191262..191987 1 NC_011741.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 191987 pyrH 7127509 pyrH Escherichia coli IAI1 uridylate kinase YP_002385664.1 191262 D 585034 CDS YP_002385665.1 218552752 7126575 192279..192836 1 NC_011741.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 192836 frr 7126575 frr Escherichia coli IAI1 ribosome recycling factor YP_002385665.1 192279 D 585034 CDS YP_002385666.1 218552753 7127284 192928..194124 1 NC_011741.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 194124 dxr 7127284 dxr Escherichia coli IAI1 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_002385666.1 192928 D 585034 CDS YP_002385667.1 218552754 7125035 194310..195071 1 NC_011741.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 195071 ispU 7125035 ispU Escherichia coli IAI1 undecaprenyl pyrophosphate synthase YP_002385667.1 194310 D 585034 CDS YP_002385668.1 218552755 7126086 195071..195223 1 NC_011741.1 hypothetical protein 195223 7126086 ECIAI1_0173 Escherichia coli IAI1 hypothetical protein YP_002385668.1 195071 D 585034 CDS YP_002385669.1 218552756 7126979 195084..195941 1 NC_011741.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 195941 cdsA 7126979 cdsA Escherichia coli IAI1 CDP-diglyceride synthase YP_002385669.1 195084 D 585034 CDS YP_002385670.1 218552757 7126297 195953..197305 1 NC_011741.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 197305 yaeL 7126297 yaeL Escherichia coli IAI1 zinc metallopeptidase RseP YP_002385670.1 195953 D 585034 CDS YP_002385671.1 218552758 7126513 197335..199767 1 NC_011741.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 199767 yaeT 7126513 yaeT Escherichia coli IAI1 outer membrane protein assembly factor YaeT YP_002385671.1 197335 D 585034 CDS YP_002385672.1 218552759 7126517 199889..200374 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15101556, 90201355, 97032152, 99386928, 1987124, 2843433, 9298646, 2167239; Product type f : factor; periplasmic chaperone 200374 hlpA 7126517 hlpA Escherichia coli IAI1 periplasmic chaperone YP_002385672.1 199889 D 585034 CDS YP_002385673.1 218552760 7125282 200378..201403 1 NC_011741.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 201403 lpxD 7125282 lpxD Escherichia coli IAI1 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_002385673.1 200378 D 585034 CDS YP_002385674.1 218552761 7127625 201508..201963 1 NC_011741.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 201963 fabZ 7127625 fabZ Escherichia coli IAI1 (3R)-hydroxymyristoyl-ACP dehydratase YP_002385674.1 201508 D 585034 CDS YP_002385675.1 218552762 7127060 201967..202755 1 NC_011741.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 202755 lpxA 7127060 lpxA Escherichia coli IAI1 UDP-N-acetylglucosamine acyltransferase YP_002385675.1 201967 D 585034 CDS YP_002385676.1 218552763 7127622 202755..203903 1 NC_011741.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 203903 lpxB 7127622 lpxB Escherichia coli IAI1 lipid-A-disaccharide synthase YP_002385676.1 202755 D 585034 CDS YP_002385677.1 218552764 7127623 203900..204496 1 NC_011741.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 204496 rnhB 7127623 rnhB Escherichia coli IAI1 ribonuclease HII YP_002385677.1 203900 D 585034 CDS YP_002385678.1 218552765 7125023 204533..208015 1 NC_011741.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 208015 dnaE 7125023 dnaE Escherichia coli IAI1 DNA polymerase III subunit alpha YP_002385678.1 204533 D 585034 CDS YP_002385679.1 218552766 7124607 208028..208987 1 NC_011741.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 208987 accA 7124607 accA Escherichia coli IAI1 acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_002385679.1 208028 D 585034 CDS YP_002385680.1 218552767 7125690 209086..211227 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97480927, 98195734, 98357244, 9226257, 9723924; Product type e : enzyme; lysine decarboxylase 2 211227 ldcC 7125690 ldcC Escherichia coli IAI1 lysine decarboxylase 2 YP_002385680.1 209086 D 585034 CDS YP_002385681.1 218552768 7126398 211284..211673 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 211673 yaeR 7126398 yaeR Escherichia coli IAI1 hypothetical protein YP_002385681.1 211284 D 585034 CDS YP_002385682.1 218552769 7126516 211738..213036 1 NC_011741.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 213036 tilS 7126516 tilS Escherichia coli IAI1 tRNA(Ile)-lysidine synthetase YP_002385682.1 211738 D 585034 CDS YP_002385683.1 218552770 7126849 complement(213085..213339) 1 NC_011741.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator 213339 rof 7126849 rof Escherichia coli IAI1 Rho-binding antiterminator YP_002385683.1 213085 R 585034 CDS YP_002385684.1 218552771 7128614 complement(213332..213532) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 213532 yaeP 7128614 yaeP Escherichia coli IAI1 hypothetical protein YP_002385684.1 213332 R 585034 CDS YP_002385685.1 218552772 7126514 213698..214243 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 214243 yaeQ 7126514 yaeQ Escherichia coli IAI1 hypothetical protein YP_002385685.1 213698 D 585034 CDS YP_002385686.1 218552773 7126515 214240..214662 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; peptidyl-tRNA hydrolase domain-containing protein 214662 yaeJ 7126515 yaeJ Escherichia coli IAI1 peptidyl-tRNA hydrolase domain-containing protein YP_002385686.1 214240 D 585034 CDS YP_002385687.1 218552774 7126512 214676..215386 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11830644, 95362641, 95362642; Product type lp : lipoprotein; lipoprotein involved with copper homeostasis and adhesion 215386 nlpE 7126512 nlpE Escherichia coli IAI1 lipoprotein involved with copper homeostasis and adhesion YP_002385687.1 214676 D 585034 CDS YP_002385688.1 218552775 7126510 complement(216418..218136) 1 NC_011741.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 218136 proS 7126510 proS Escherichia coli IAI1 prolyl-tRNA synthetase YP_002385688.1 216418 R 585034 CDS YP_002385689.1 218552776 7126161 complement(218248..218955) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 218955 yaeB 7126161 yaeB Escherichia coli IAI1 hypothetical protein YP_002385689.1 218248 R 585034 CDS YP_002385690.1 218552777 7126508 complement(218952..219356) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 93094132; Product type pr : putative regulator; outer membrane lipoprotein 219356 rcsF 7126508 rcsF Escherichia coli IAI1 outer membrane lipoprotein YP_002385690.1 218952 R 585034 CDS YP_002385691.1 218552778 7126602 complement(219474..220289) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12169620, 12218041, 12819857, 1459951; Product type t : transporter; DL-methionine transporter substrate-binding subunit 220289 metQ 7126602 metQ Escherichia coli IAI1 DL-methionine transporter substrate-binding subunit YP_002385691.1 219474 R 585034 CDS YP_002385692.1 218552779 7124254 complement(220329..220982) 1 NC_011741.1 part of the MetNIQ methionine uptake system; DL-methionine transporter permease subunit 220982 metI 7124254 metI Escherichia coli IAI1 DL-methionine transporter permease subunit YP_002385692.1 220329 R 585034 CDS YP_002385693.1 218552780 7124249 complement(220975..222006) 1 NC_011741.1 part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit 222006 metN 7124249 metN Escherichia coli IAI1 DL-methionine transporter ATP-binding subunit YP_002385693.1 220975 R 585034 CDS YP_002385694.1 218552781 7124253 222194..222766 1 NC_011741.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 222766 gmhB 7124253 gmhB Escherichia coli IAI1 D,D-heptose 1,7-bisphosphate phosphatase YP_002385694.1 222194 D 585034 CDS YP_002385695.1 218552782 7128005 228526..229329 1 NC_011741.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 229329 dkgB 7128005 dkgB Escherichia coli IAI1 2,5-diketo-D-gluconate reductase B YP_002385695.1 228526 D 585034 CDS YP_002385696.1 218552783 7124597 complement(229326..230240) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 230240 yafC 7124597 yafC Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002385696.1 229326 R 585034 CDS YP_002385697.1 218552784 7126518 230481..231281 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1663890; hypothetical protein 231281 yafD 7126518 yafD Escherichia coli IAI1 hypothetical protein YP_002385697.1 230481 D 585034 CDS YP_002385698.1 218552785 7126519 231359..232129 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase 232129 yafE 7126519 yafE Escherichia coli IAI1 putative S-adenosyl-L-methionine-dependent methyltransferase YP_002385698.1 231359 D 585034 CDS YP_002385699.1 218552786 7126520 complement(232177..233535) 1 NC_011741.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D 233535 mltD 7126520 mltD Escherichia coli IAI1 membrane-bound lytic murein transglycosylase D YP_002385699.1 232177 R 585034 CDS YP_002385700.1 218552787 7124284 complement(233607..234362) 1 NC_011741.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase 234362 gloB 7124284 gloB Escherichia coli IAI1 hydroxyacylglutathione hydrolase YP_002385700.1 233607 R 585034 CDS YP_002385701.1 218552788 7128333 234396..235118 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase 235118 yafS 7128333 yafS Escherichia coli IAI1 putative S-adenosyl-L-methionine-dependent methyltransferase YP_002385701.1 234396 D 585034 CDS YP_002385702.1 218552789 7126526 complement(235115..235582) 1 NC_011741.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 235582 rnhA 7126526 rnhA Escherichia coli IAI1 ribonuclease H YP_002385702.1 235115 R 585034 CDS YP_002385703.1 218552790 7125022 235647..236378 1 NC_011741.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 236378 dnaQ 7125022 dnaQ Escherichia coli IAI1 DNA polymerase III subunit epsilon YP_002385703.1 235647 D 585034 CDS YP_002385704.1 218552791 7128016 236914..237699 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aminopeptidase 237699 yafT 7128016 yafT Escherichia coli IAI1 putative aminopeptidase YP_002385704.1 236914 D 585034 CDS YP_002385705.1 218552792 7124431 complement(238325..239254) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15919996; Product type m : membrane component; Inner membrane protein yafU 239254 yafU 7124431 yafU Escherichia coli IAI1 Inner membrane protein yafU YP_002385705.1 238325 R 585034 CDS YP_002385706.1 218552793 7126689 complement(239283..239765) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 239765 7126689 ECIAI1_0227 Escherichia coli IAI1 hypothetical protein YP_002385706.1 239283 R 585034 CDS YP_002385707.1 218552794 7126980 complement(239789..241231) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 241231 7126980 ECIAI1_0228 Escherichia coli IAI1 hypothetical protein YP_002385707.1 239789 R 585034 CDS YP_002385708.1 218552795 7126981 complement(241152..244676) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; IcmF-like protein 244676 7126981 ECIAI1_0229 Escherichia coli IAI1 IcmF-like protein YP_002385708.1 241152 R 585034 CDS YP_002385709.1 218552796 7126982 complement(244695..246173) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 246173 7126982 ECIAI1_0230 Escherichia coli IAI1 hypothetical protein YP_002385709.1 244695 R 585034 CDS YP_002385710.1 218552797 7126983 complement(246112..246855) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 246855 7126983 ECIAI1_0231 Escherichia coli IAI1 hypothetical protein YP_002385710.1 246112 R 585034 CDS YP_002385711.1 218552798 7126984 complement(246852..249791) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative ATP-dependent Clp proteinase Aec27 ATP-binding chain, with chaperone activity 249791 7126984 ECIAI1_0232 Escherichia coli IAI1 putative ATP-dependent Clp proteinase Aec27 ATP-binding chain, with chaperone activity YP_002385711.1 246852 R 585034 CDS YP_002385712.1 218552799 7126985 complement(249686..250447) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 250447 7126985 ECIAI1_0233 Escherichia coli IAI1 hypothetical protein YP_002385712.1 249686 R 585034 CDS YP_002385713.1 218552800 7126986 complement(250452..251783) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 251783 7126986 ECIAI1_0234 Escherichia coli IAI1 hypothetical protein YP_002385713.1 250452 R 585034 CDS YP_002385714.1 218552801 7126987 complement(251786..252310) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 252310 7126987 ECIAI1_0235 Escherichia coli IAI1 hypothetical protein YP_002385714.1 251786 R 585034 CDS YP_002385715.1 218552802 7126988 complement(252307..253608) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 253608 7126988 ECIAI1_0236 Escherichia coli IAI1 hypothetical protein YP_002385715.1 252307 R 585034 CDS YP_002385716.1 218552803 7126989 complement(253612..254700) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 254700 7126989 ECIAI1_0237 Escherichia coli IAI1 hypothetical protein YP_002385716.1 253612 R 585034 CDS YP_002385717.1 218552804 7126990 complement(254658..256508) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 256508 7126990 ECIAI1_0238 Escherichia coli IAI1 hypothetical protein YP_002385717.1 254658 R 585034 CDS YP_002385718.1 218552805 7126991 complement(256512..256925) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 256925 7126991 ECIAI1_0239 Escherichia coli IAI1 hypothetical protein YP_002385718.1 256512 R 585034 CDS YP_002385719.1 218552806 7126992 complement(256932..258407) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 258407 7126992 ECIAI1_0240 Escherichia coli IAI1 hypothetical protein YP_002385719.1 256932 R 585034 CDS YP_002385720.1 218552807 7126993 complement(258458..258682) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 258682 7126993 ECIAI1_0241 Escherichia coli IAI1 hypothetical protein YP_002385720.1 258458 R 585034 CDS YP_002385721.1 218552808 7126994 complement(258717..259217) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 259217 7126994 ECIAI1_0242 Escherichia coli IAI1 hypothetical protein YP_002385721.1 258717 R 585034 CDS YP_002385722.1 218552809 7126995 259643..259786 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 259786 7126995 ECIAI1_0243 Escherichia coli IAI1 hypothetical protein YP_002385722.1 259643 D 585034 CDS YP_002385723.1 218552810 7126996 259913..260431 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 260431 7126996 ECIAI1_0244 Escherichia coli IAI1 hypothetical protein YP_002385723.1 259913 D 585034 CDS YP_002385724.1 218552811 7126997 260641..262782 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 262782 7126997 ECIAI1_0245 Escherichia coli IAI1 hypothetical protein YP_002385724.1 260641 D 585034 CDS YP_002385725.1 218552812 7126998 262858..267084 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; RhsG core protein with extension 267084 7126998 ECIAI1_0246 Escherichia coli IAI1 RhsG core protein with extension YP_002385725.1 262858 D 585034 CDS YP_002385726.1 218552813 7126999 267087..267557 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 267557 7126999 ECIAI1_0247 Escherichia coli IAI1 hypothetical protein YP_002385726.1 267087 D 585034 CDS YP_002385727.1 218552814 7127000 complement(267665..267811) 1 NC_011741.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 267811 7127000 ECIAI1_0248 Escherichia coli IAI1 hypothetical protein YP_002385727.1 267665 R 585034 CDS YP_002385728.1 218552815 7127140 268579..269544 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype; putative transposase 269544 yhhI 7127140 yhhI Escherichia coli IAI1 putative transposase YP_002385728.1 268579 D 585034 CDS YP_002385729.1 218552816 7127141 269547..270026 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9696756; hypothetical protein 270026 7127141 ECIAI1_0251 Escherichia coli IAI1 hypothetical protein YP_002385729.1 269547 D 585034 CDS YP_002385730.1 218552817 7127002 270292..270486 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 270486 7127002 ECIAI1_0252 Escherichia coli IAI1 hypothetical protein YP_002385730.1 270292 D 585034 CDS YP_002385731.1 218552818 7127003 270561..274814 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9696756; Product type h : extrachromosomal origin; putative Rhs Core protein 274814 7127003 ECIAI1_0253 Escherichia coli IAI1 putative Rhs Core protein YP_002385731.1 270561 D 585034 CDS YP_002385732.1 218552819 7127004 274798..275280 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 275280 ydcD 7127004 ydcD Escherichia coli IAI1 hypothetical protein YP_002385732.1 274798 D 585034 CDS YP_002385733.1 218552820 7127373 275246..275413 1 NC_011741.1 hypothetical protein 275413 7127373 ECIAI1_0255 Escherichia coli IAI1 hypothetical protein YP_002385733.1 275246 D 585034 CDS YP_002385734.1 218552821 7127005 275462..276208 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7868617, 8387990; hypothetical protein 276208 yncI 7127005 yncI Escherichia coli IAI1 hypothetical protein YP_002385734.1 275462 D 585034 CDS YP_002385735.1 218552822 7127548 276252..276452 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7868617, 8387990; hypothetical protein 276452 yncM 7127548 yncM Escherichia coli IAI1 hypothetical protein YP_002385735.1 276252 D 585034 CDS YP_002385736.1 218552823 7127551 276766..277827 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype; putative transposase 277827 yhhI 7127551 yhhI Escherichia coli IAI1 putative transposase YP_002385736.1 276766 D 585034 CDS YP_002385737.1 218552824 7127142 complement(277869..278639) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8526497; Product type pe : putative enzyme; hypothetical protein 278639 yafV 7127142 yafV Escherichia coli IAI1 hypothetical protein YP_002385737.1 277869 R 585034 CDS YP_002385738.1 218552825 7126690 278793..279266 1 NC_011741.1 inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 279266 ivy 7126690 ivy Escherichia coli IAI1 C-lysozyme inhibitor YP_002385738.1 278793 D 585034 CDS YP_002385739.1 218552826 7126091 complement(279309..281753) 1 NC_011741.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase 281753 fadE 7126091 fadE Escherichia coli IAI1 acyl-CoA dehydrogenase YP_002385739.1 279309 R 585034 CDS YP_002385740.1 218552827 7127064 281993..282571 1 NC_011741.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 282571 gmhA 7127064 gmhA Escherichia coli IAI1 phosphoheptose isomerase YP_002385740.1 281993 D 585034 CDS YP_002385741.1 218552828 7126439 282777..283544 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutamine amidotransferases class-II 283544 yafJ 7126439 yafJ Escherichia coli IAI1 putative glutamine amidotransferases class-II YP_002385741.1 282777 D 585034 CDS YP_002385742.1 218552829 7126521 complement(283515..284255) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 284255 yafK 7126521 yafK Escherichia coli IAI1 hypothetical protein YP_002385742.1 283515 R 585034 CDS YP_002385743.1 218552830 7126522 complement(284411..284689) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15009896; Product type f : factor; toxin of the YafQ-DinJ toxin-antitoxin system 284689 yafQ 7126522 yafQ Escherichia coli IAI1 toxin of the YafQ-DinJ toxin-antitoxin system YP_002385743.1 284411 R 585034 CDS YP_002385744.1 218552831 7126525 complement(284692..284952) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99451883; Product type pf : putative factor; antitoxin of YafQ-DinJ toxin-antitoxin system 284952 dinJ 7126525 dinJ Escherichia coli IAI1 antitoxin of YafQ-DinJ toxin-antitoxin system YP_002385744.1 284692 R 585034 CDS YP_002385745.1 218552832 7124591 285162..285911 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported hydrolase 285911 yafL 7124591 yafL Escherichia coli IAI1 putative exported hydrolase YP_002385745.1 285162 D 585034 CDS YP_002385746.1 218552833 7126523 complement(285968..286324) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 286324 7126523 ECIAI1_0268 Escherichia coli IAI1 hypothetical protein YP_002385746.1 285968 R 585034 CDS YP_002385747.1 218552834 7127006 complement(286317..286616) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 286616 7127006 ECIAI1_0269 Escherichia coli IAI1 hypothetical protein YP_002385747.1 286317 R 585034 CDS YP_002385748.1 218552835 7127007 complement(286700..288439) 1 NC_011741.1 Evidence 7 : Gene remnant; Product type s : structure; flagellar system protein 288439 fhiA 7127007 fhiA Escherichia coli IAI1 flagellar system protein YP_002385748.1 286700 R 585034 CDS YP_002385749.1 218552836 7127096 288279..289169 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15687208; Product type s : structure; hypothetical protein 289169 mbhA 7127096 mbhA Escherichia coli IAI1 hypothetical protein YP_002385749.1 288279 D 585034 CDS YP_002385750.1 218552837 7127678 289240..290295 1 NC_011741.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 290295 dinB 7127678 dinB Escherichia coli IAI1 DNA polymerase IV YP_002385750.1 289240 D 585034 CDS YP_002385751.1 218552838 7124586 290292..290744 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12813093; Product type pe : putative enzyme; hypothetical protein 290744 yafP 7124586 yafP Escherichia coli IAI1 hypothetical protein YP_002385751.1 290292 D 585034 CDS YP_002385752.1 218552839 7126524 290963..292129 1 NC_011741.1 mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY; hypothetical protein 292129 7126524 ECIAI1_0274 Escherichia coli IAI1 hypothetical protein YP_002385752.1 290963 D 585034 CDS YP_002385753.1 218552840 7127008 292240..292740 1 NC_011741.1 similar to release factor 1 and 2; peptide chain release factor-like protein 292740 prfH 7127008 prfH Escherichia coli IAI1 peptide chain release factor-like protein YP_002385753.1 292240 D 585034 CDS YP_002385754.1 218552841 7126147 complement(292797..294254) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1695895, 21101837, 88121730, 92204123, 2651887; Product type e : enzyme; aminoacyl-histidine dipeptidase ABC transporter periplasmic-binding protein 294254 pepD 7126147 pepD Escherichia coli IAI1 aminoacyl-histidine dipeptidase ABC transporter periplasmic-binding protein YP_002385754.1 292797 R 585034 CDS YP_002385755.1 218552842 7124171 294515..294973 1 NC_011741.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 294973 gpt 7124171 gpt Escherichia coli IAI1 xanthine-guanine phosphoribosyltransferase YP_002385755.1 294515 D 585034 CDS YP_002385756.1 218552843 7128462 295065..296309 1 NC_011741.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 296309 frsA 7128462 frsA Escherichia coli IAI1 fermentation/respiration switch protein YP_002385756.1 295065 D 585034 CDS YP_002385757.1 218552844 7127285 296367..296768 1 NC_011741.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 296768 crl 7127285 crl Escherichia coli IAI1 DNA-binding transcriptional regulator Crl YP_002385757.1 296367 D 585034 CDS YP_002385758.1 218552845 7126369 complement(296807..297862) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89178658, 89380253, 92219258, 98090453, 1380671, 1848301, 1848682, 6089111, 6341601, 7679770; Product type t : transporter; outer membrane phosphoporin protein E 297862 phoE 7126369 phoE Escherichia coli IAI1 outer membrane phosphoporin protein E YP_002385758.1 296807 R 585034 CDS YP_002385759.1 218552846 7124216 298150..299253 1 NC_011741.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 299253 proB 7124216 proB Escherichia coli IAI1 gamma-glutamyl kinase YP_002385759.1 298150 D 585034 CDS YP_002385760.1 218552847 7126157 299265..300518 1 NC_011741.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 300518 proA 7126157 proA Escherichia coli IAI1 gamma-glutamyl phosphate reductase YP_002385760.1 299265 D 585034 CDS YP_002385761.1 218552848 7128027 complement(300835..301245) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 301245 yagP 7128027 yagP Escherichia coli IAI1 putative transcriptional regulator YP_002385761.1 300835 R 585034 CDS YP_002385762.1 218552849 7126691 complement(301224..302180) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 302180 yagQ 7126691 yagQ Escherichia coli IAI1 hypothetical protein YP_002385762.1 301224 R 585034 CDS YP_002385763.1 218552850 7126692 complement(302190..304388) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 304388 yagR 7126692 yagR Escherichia coli IAI1 putative oxidoreductase YP_002385763.1 302190 R 585034 CDS YP_002385764.1 218552851 7126693 complement(304385..305341) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 305341 yagS 7126693 yagS Escherichia coli IAI1 putative oxidoreductase YP_002385764.1 304385 R 585034 CDS YP_002385765.1 218552852 7126694 complement(305338..306027) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative xanthine dehydrogenase iron-sulfur-binding subunit 306027 yagT 7126694 yagT Escherichia coli IAI1 putative xanthine dehydrogenase iron-sulfur-binding subunit YP_002385765.1 305338 R 585034 CDS YP_002385766.1 218552853 7126695 306445..307059 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 307059 yagU 7126695 yagU Escherichia coli IAI1 hypothetical protein YP_002385766.1 306445 D 585034 CDS YP_002385767.1 218552854 7126696 307133..307312 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 307312 7126696 ECIAI1_0289 Escherichia coli IAI1 hypothetical protein YP_002385767.1 307133 D 585034 CDS YP_002385768.1 218552855 7127009 complement(307949..308659) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 308659 yagV 7127009 yagV Escherichia coli IAI1 hypothetical protein YP_002385768.1 307949 R 585034 CDS YP_002385769.1 218552856 7126697 complement(308628..310271) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative surface or exported protein 310271 yagW 7126697 yagW Escherichia coli IAI1 putative surface or exported protein YP_002385769.1 308628 R 585034 CDS YP_002385770.1 218552857 7126698 complement(310261..312786) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 312786 yagX 7126698 yagX Escherichia coli IAI1 hypothetical protein YP_002385770.1 310261 R 585034 CDS YP_002385771.1 218552858 7126699 complement(312812..313480) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 313480 yagY 7126699 yagY Escherichia coli IAI1 hypothetical protein YP_002385771.1 312812 R 585034 CDS YP_002385772.1 218552859 7126700 complement(313538..314125) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 17563352, 11466275; Product type s : structure; common pilus ECP 314125 ecpA 7126700 ecpA Escherichia coli IAI1 common pilus ECP YP_002385772.1 313538 R 585034 CDS YP_002385773.1 218552860 7125046 complement(314200..314790) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 314790 ykgK 7125046 ykgK Escherichia coli IAI1 putative transcriptional regulator YP_002385773.1 314200 R 585034 CDS YP_002385774.1 218552861 7126652 complement(315967..316230) 1 NC_011741.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B 316230 rpmE2 7126652 rpmE2 Escherichia coli IAI1 50S ribosomal protein L31 type B YP_002385774.1 315967 R 585034 CDS YP_002385775.1 218552862 7126653 317810..322063 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative adhesin 322063 7126653 ECIAI1_0297 Escherichia coli IAI1 putative adhesin YP_002385775.1 317810 D 585034 CDS YP_002385776.1 218552863 7127010 complement(322185..323042) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator ykgA 323042 ykgA 7127010 ykgA Escherichia coli IAI1 putative transcriptional regulator ykgA YP_002385776.1 322185 R 585034 CDS YP_002385777.1 218552864 7126643 complement(323638..324237) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 324237 ykgB 7126643 ykgB Escherichia coli IAI1 hypothetical protein YP_002385777.1 323638 R 585034 CDS YP_002385778.1 218552865 7126644 complement(324240..324476) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 324476 ykgI 7126644 ykgI Escherichia coli IAI1 hypothetical protein YP_002385778.1 324240 R 585034 CDS YP_002385779.1 218552866 7126651 complement(324585..325910) 1 NC_011741.1 Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 325910 ykgC 7126651 ykgC Escherichia coli IAI1 pyridine nucleotide-disulfide oxidoreductase YP_002385779.1 324585 R 585034 CDS YP_002385780.1 218552867 7126645 326136..326990 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative AraC-type DNA-binding transcriptional regulator 326990 ykgD 7126645 ykgD Escherichia coli IAI1 putative AraC-type DNA-binding transcriptional regulator YP_002385780.1 326136 D 585034 CDS YP_002385781.1 218552868 7126646 327517..328236 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydroxyacid oxidoreductase 328236 ykgE 7126646 ykgE Escherichia coli IAI1 putative hydroxyacid oxidoreductase YP_002385781.1 327517 D 585034 CDS YP_002385782.1 218552869 7126647 328247..329674 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase subunit 329674 ykgF 7126647 ykgF Escherichia coli IAI1 putative oxidoreductase subunit YP_002385782.1 328247 D 585034 CDS YP_002385783.1 218552870 7126648 329667..330362 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 330362 ykgG 7126648 ykgG Escherichia coli IAI1 hypothetical protein YP_002385783.1 329667 D 585034 CDS YP_002385784.1 218552871 7126649 complement(330436..330633) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 330633 7126649 ECIAI1_0306 Escherichia coli IAI1 hypothetical protein YP_002385784.1 330436 R 585034 CDS YP_002385785.1 218552872 7127011 complement(330608..331273) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 331273 ykgH 7127011 ykgH Escherichia coli IAI1 hypothetical protein YP_002385785.1 330608 R 585034 CDS YP_002385786.1 218552873 7126650 complement(331485..333155) 1 NC_011741.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase 333155 betA 7126650 betA Escherichia coli IAI1 choline dehydrogenase YP_002385786.1 331485 R 585034 CDS YP_002385787.1 218552874 7124394 complement(333169..334641) 1 NC_011741.1 catalyzes the formation of betaine from betaine aldehyde; betaine aldehyde dehydrogenase 334641 betB 7124394 betB Escherichia coli IAI1 betaine aldehyde dehydrogenase YP_002385787.1 333169 R 585034 CDS YP_002385788.1 218552875 7124395 complement(334655..335242) 1 NC_011741.1 HTH-type; bet1; Repressor involved in choline regulation of the bet genes; transcriptional regulator BetI 335242 betI 7124395 betI Escherichia coli IAI1 transcriptional regulator BetI YP_002385788.1 334655 R 585034 CDS YP_002385789.1 218552876 7124396 335371..337404 1 NC_011741.1 proton-motive-force-driven choline transporter; choline transport protein BetT 337404 betT 7124396 betT Escherichia coli IAI1 choline transport protein BetT YP_002385789.1 335371 D 585034 CDS YP_002385790.1 218552877 7124397 337911..341960 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type pm : putative membrane component; AidA-I adhesin-like protein 341960 7124397 ECIAI1_0312 Escherichia coli IAI1 AidA-I adhesin-like protein YP_002385790.1 337911 D 585034 CDS YP_002385791.1 218552878 7127012 342102..343190 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15995192; Product type e : enzyme; cyclic di-GMP phosphodiesterase 343190 yahA 7127012 yahA Escherichia coli IAI1 cyclic di-GMP phosphodiesterase YP_002385791.1 342102 D 585034 CDS YP_002385792.1 218552879 7126701 complement(343232..344164) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 344164 yahB 7126701 yahB Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002385792.1 343232 R 585034 CDS YP_002385793.1 218552880 7126702 complement(344256..344753) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 344753 yahC 7126702 yahC Escherichia coli IAI1 hypothetical protein YP_002385793.1 344256 R 585034 CDS YP_002385794.1 218552881 7126703 345011..345616 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 345616 yahD 7126703 yahD Escherichia coli IAI1 hypothetical protein YP_002385794.1 345011 D 585034 CDS YP_002385795.1 218552882 7126704 345656..346519 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 346519 yahE 7126704 yahE Escherichia coli IAI1 hypothetical protein YP_002385795.1 345656 D 585034 CDS YP_002385796.1 218552883 7126705 346509..348056 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 348056 yahF 7126705 yahF Escherichia coli IAI1 hypothetical protein YP_002385796.1 346509 D 585034 CDS YP_002385797.1 218552884 7126706 348056..349474 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 349474 yahG 7126706 yahG Escherichia coli IAI1 hypothetical protein YP_002385797.1 348056 D 585034 CDS YP_002385798.1 218552885 7126707 349617..350567 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7711027, 11523892; Product type pe : putative enzyme; putative carbamate kinase 350567 yahI 7126707 yahI Escherichia coli IAI1 putative carbamate kinase YP_002385798.1 349617 D 585034 CDS YP_002385799.1 218552886 7126708 350577..351959 1 NC_011741.1 metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain; putative deaminase 351959 yahJ 7126708 yahJ Escherichia coli IAI1 putative deaminase YP_002385799.1 350577 D 585034 CDS YP_002385800.1 218552887 7126709 352228..352668 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 352668 7126709 ECIAI1_0322 Escherichia coli IAI1 hypothetical protein YP_002385800.1 352228 D 585034 CDS YP_002385801.1 218552888 7127013 352920..353906 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ribose ABC transporter substrate-binding protein 353906 7127013 ECIAI1_0323 Escherichia coli IAI1 putative ribose ABC transporter substrate-binding protein YP_002385801.1 352920 D 585034 CDS YP_002385802.1 218552889 7127014 353940..355439 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar ABC transporter ATP-binding protein 355439 7127014 ECIAI1_0324 Escherichia coli IAI1 putative sugar ABC transporter ATP-binding protein YP_002385802.1 353940 D 585034 CDS YP_002385803.1 218552890 7127015 355432..356403 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative sugar ABC transporter permease 356403 7127015 ECIAI1_0325 Escherichia coli IAI1 putative sugar ABC transporter permease YP_002385803.1 355432 D 585034 CDS YP_002385804.1 218552891 7127016 356370..357356 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative sugar ABC transporter permease 357356 7127016 ECIAI1_0326 Escherichia coli IAI1 putative sugar ABC transporter permease YP_002385804.1 356370 D 585034 CDS YP_002385805.1 218552892 7127017 357443..358492 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 358492 yahK 7127017 yahK Escherichia coli IAI1 putative oxidoreductase YP_002385805.1 357443 D 585034 CDS YP_002385806.1 218552893 7126710 358735..359550 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 359550 yahL 7126710 yahL Escherichia coli IAI1 hypothetical protein YP_002385806.1 358735 D 585034 CDS YP_002385807.1 218552894 7128038 359963..360208 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 360208 yahM 7128038 yahM Escherichia coli IAI1 hypothetical protein YP_002385807.1 359963 D 585034 CDS YP_002385808.1 218552895 7126712 complement(360225..360896) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12879215; Product type t : transporter; neutral amino-acid efflux system 360896 yahN 7126712 yahN Escherichia coli IAI1 neutral amino-acid efflux system YP_002385808.1 360225 R 585034 CDS YP_002385809.1 218552896 7126713 361043..361318 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 361318 yahO 7126713 yahO Escherichia coli IAI1 hypothetical protein YP_002385809.1 361043 D 585034 CDS YP_002385810.1 218552897 7126714 complement(361419..363005) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9325432, 15805526; Product type r : regulator; DNA-binding transcriptional activator 363005 prpR 7126714 prpR Escherichia coli IAI1 DNA-binding transcriptional activator YP_002385810.1 361419 R 585034 CDS YP_002385811.1 218552898 7126170 363244..364134 1 NC_011741.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase 364134 prpB 7126170 prpB Escherichia coli IAI1 2-methylisocitrate lyase YP_002385811.1 363244 D 585034 CDS YP_002385812.1 218552899 7126166 364179..365348 1 NC_011741.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase 365348 prpC 7126166 prpC Escherichia coli IAI1 methylcitrate synthase YP_002385812.1 364179 D 585034 CDS YP_002385813.1 218552900 7126167 365382..366833 1 NC_011741.1 functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C; 2-methylcitrate dehydratase 366833 prpD 7126167 prpD Escherichia coli IAI1 2-methylcitrate dehydratase YP_002385813.1 365382 D 585034 CDS YP_002385814.1 218552901 7126168 366873..368759 1 NC_011741.1 catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; propionyl-CoA synthetase 368759 prpE 7126168 prpE Escherichia coli IAI1 propionyl-CoA synthetase YP_002385814.1 366873 D 585034 CDS YP_002385815.1 218552902 7126169 369127..370107 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 370107 7126169 ECIAI1_0337 Escherichia coli IAI1 transposase, IS110 family YP_002385815.1 369127 D 585034 CDS YP_002385816.1 218552903 7127018 370376..371635 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92349961; Product type t : transporter; cytosine permease 371635 codB 7127018 codB Escherichia coli IAI1 cytosine permease YP_002385816.1 370376 D 585034 CDS YP_002385817.1 218552904 7126350 371625..372908 1 NC_011741.1 Catalyzes the deamination of cytosine to uracil and ammonia; cytosine deaminase 372908 codA 7126350 codA Escherichia coli IAI1 cytosine deaminase YP_002385817.1 371625 D 585034 CDS YP_002385818.1 218552905 7126349 complement(372948..373847) 1 NC_011741.1 controls the expression of the cynTSX operon involved in degrading and using cyanate as a sole nitrogen source; DNA-binding transcriptional regulator CynR 373847 cynR 7126349 cynR Escherichia coli IAI1 DNA-binding transcriptional regulator CynR YP_002385818.1 372948 R 585034 CDS YP_002385819.1 218552906 7126878 373957..374616 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91242169, 92156106, 94075239, 3049588; Product type e : enzyme; carbonic anhydrase 374616 cynT 7126878 cynT Escherichia coli IAI1 carbonic anhydrase YP_002385819.1 373957 D 585034 CDS YP_002385820.1 218552907 7126880 374647..375117 1 NC_011741.1 catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide; cyanate hydratase 375117 cynS 7126880 cynS Escherichia coli IAI1 cyanate hydratase YP_002385820.1 374647 D 585034 CDS YP_002385821.1 218552908 7126879 375150..376304 1 NC_011741.1 MFS transporter family member induced in the presence of cyanate as part of a 3 gene operon; not essential; putative cyanate transporter 376304 cynX 7126879 cynX Escherichia coli IAI1 putative cyanate transporter YP_002385821.1 375150 D 585034 CDS YP_002385822.1 218552909 7126881 complement(376383..377636) 1 NC_011741.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease 377636 lacY 7126881 lacY Escherichia coli IAI1 galactoside permease YP_002385822.1 376383 R 585034 CDS YP_002385823.1 218552910 7126394 complement(377688..380762) 1 NC_011741.1 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon; beta-D-galactosidase 380762 lacZ 7126394 lacZ Escherichia coli IAI1 beta-D-galactosidase YP_002385823.1 377688 R 585034 CDS YP_002385824.1 218552911 7126395 complement(380885..381967) 1 NC_011741.1 transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor 381967 lacI 7126395 lacI Escherichia coli IAI1 lac repressor YP_002385824.1 380885 R 585034 CDS YP_002385825.1 218552912 7126393 complement(382044..382991) 1 NC_011741.1 activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional activator MhpR 382991 mhpR 7126393 mhpR Escherichia coli IAI1 DNA-binding transcriptional activator MhpR YP_002385825.1 382044 R 585034 CDS YP_002385826.1 218552913 7124268 383068..384732 1 NC_011741.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 384732 mhpA 7124268 mhpA Escherichia coli IAI1 3-(3-hydroxyphenyl)propionate hydroxylase YP_002385826.1 383068 D 585034 CDS YP_002385827.1 218552914 7124262 384734..385678 1 NC_011741.1 catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family; 3-(2,3-dihydroxyphenyl)propionate dioxygenase 385678 mhpB 7124262 mhpB Escherichia coli IAI1 3-(2,3-dihydroxyphenyl)propionate dioxygenase YP_002385827.1 384734 D 585034 CDS YP_002385828.1 218552915 7124263 385681..386562 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87008429, 94002258, 15663942; Product type e : enzyme; 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase 386562 mhpC 7124263 mhpC Escherichia coli IAI1 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase YP_002385828.1 385681 D 585034 CDS YP_002385829.1 218552916 7124264 386572..387381 1 NC_011741.1 catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid; 2-keto-4-pentenoate hydratase 387381 mhpD 7124264 mhpD Escherichia coli IAI1 2-keto-4-pentenoate hydratase YP_002385829.1 386572 D 585034 CDS YP_002385830.1 218552917 7124265 387378..388328 1 NC_011741.1 catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 388328 mhpF 7124265 mhpF Escherichia coli IAI1 acetaldehyde dehydrogenase YP_002385830.1 387378 D 585034 CDS YP_002385831.1 218552918 7124267 388325..389338 1 NC_011741.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 389338 mhpE 7124267 mhpE Escherichia coli IAI1 4-hydroxy-2-ketovalerate aldolase YP_002385831.1 388325 D 585034 CDS YP_002385832.1 218552919 7124266 389514..390725 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7961399; Product type t : transporter; putative 3-hydroxyphenylpropionic transporter MhpT 390725 mhpT 7124266 mhpT Escherichia coli IAI1 putative 3-hydroxyphenylpropionic transporter MhpT YP_002385832.1 389514 D 585034 CDS YP_002385833.1 218552920 7124269 390827..391366 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15115803, 12878731, 13129938; Product type e : enzyme; nucleoprotein/polynucleotide-associated enzyme 391366 yaiL 7124269 yaiL Escherichia coli IAI1 nucleoprotein/polynucleotide-associated enzyme YP_002385833.1 390827 D 585034 CDS YP_002385834.1 218552921 7126720 complement(391491..392324) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16567800, 15466022; Product type e : enzyme; S-formylglutathione hydrolase 392324 frmB 7126720 frmB Escherichia coli IAI1 S-formylglutathione hydrolase YP_002385834.1 391491 R 585034 CDS YP_002385835.1 218552922 7127281 complement(392417..393526) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15466022, 87172301, 1731906; Product type e : enzyme; alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase 393526 frmA 7127281 frmA Escherichia coli IAI1 alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase YP_002385835.1 392417 R 585034 CDS YP_002385836.1 218552923 7127280 complement(393561..393836) 1 NC_011741.1 formaldehyde-induced negative regulator of the frmRAB operon; regulator protein FrmR 393836 frmR 7127280 frmR Escherichia coli IAI1 regulator protein FrmR YP_002385836.1 393561 R 585034 CDS YP_002385837.1 218552924 7127283 complement(394021..394794) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 394794 yaiO 7127283 yaiO Escherichia coli IAI1 hypothetical protein YP_002385837.1 394021 R 585034 CDS YP_002385838.1 218552925 7126721 complement(394796..395506) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transferase 395506 yaiX 7126721 yaiX Escherichia coli IAI1 putative transferase YP_002385838.1 394796 R 585034 CDS YP_002385839.1 218552926 7126726 complement(395355..396551) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated glycosyltransferase 396551 yaiP 7126726 yaiP Escherichia coli IAI1 putative membrane-associated glycosyltransferase YP_002385839.1 395355 R 585034 CDS YP_002385840.1 218552927 7126722 complement(396561..397232) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 397232 yaiS 7126722 yaiS Escherichia coli IAI1 hypothetical protein YP_002385840.1 396561 R 585034 CDS YP_002385841.1 218552928 7126723 397848..398810 1 NC_011741.1 with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit 398810 tauA 7126723 tauA Escherichia coli IAI1 taurine transporter substrate binding subunit YP_002385841.1 397848 D 585034 CDS YP_002385842.1 218552929 7126219 398823..399590 1 NC_011741.1 Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding subunit 399590 tauB 7126219 tauB Escherichia coli IAI1 taurine transporter ATP-binding subunit YP_002385842.1 398823 D 585034 CDS YP_002385843.1 218552930 7126220 399587..400414 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9401024, 96404792; Product type t : transporter; taurine transporter subunit 400414 tauC 7126220 tauC Escherichia coli IAI1 taurine transporter subunit YP_002385843.1 399587 D 585034 CDS YP_002385844.1 218552931 7126221 400411..401262 1 NC_011741.1 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase 401262 tauD 7126221 tauD Escherichia coli IAI1 taurine dioxygenase YP_002385844.1 400411 D 585034 CDS YP_002385845.1 218552932 7126222 complement(401368..402342) 1 NC_011741.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 402342 hemB 7126222 hemB Escherichia coli IAI1 delta-aminolevulinic acid dehydratase YP_002385845.1 401368 R 585034 CDS YP_002385846.1 218552933 7128506 402865..405843 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative flagellin structural protein 405843 7128506 ECIAI1_0369 Escherichia coli IAI1 putative flagellin structural protein YP_002385846.1 402865 D 585034 CDS YP_002385847.1 218552934 7127019 405886..406554 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative DNA-binding transcriptional regulator 406554 yaiV 7127019 yaiV Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002385847.1 405886 D 585034 CDS YP_002385848.1 218552935 7126724 complement(406555..407712) 1 NC_011741.1 this protein has no known enzymatic function; beta-lactam binding protein AmpH 407712 ampH 7126724 ampH Escherichia coli IAI1 beta-lactam binding protein AmpH YP_002385848.1 406555 R 585034 CDS YP_002385849.1 218552936 7125760 407850..408044 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 408044 7125760 ECIAI1_0372 Escherichia coli IAI1 hypothetical protein YP_002385849.1 407850 D 585034 CDS YP_002385850.1 218552937 7127020 408064..409284 1 NC_011741.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transport protein 409284 sbmA 7127020 sbmA Escherichia coli IAI1 transport protein YP_002385850.1 408064 D 585034 CDS YP_002385851.1 218552938 7124678 409297..410391 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 410391 yaiW 7124678 yaiW Escherichia coli IAI1 hypothetical protein YP_002385851.1 409297 D 585034 CDS YP_002385852.1 218552939 7126725 complement(410450..410758) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 410758 yaiY 7126725 yaiY Escherichia coli IAI1 hypothetical protein YP_002385852.1 410450 R 585034 CDS YP_002385853.1 218552940 7126727 410886..411230 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 411230 yaiZ 7126727 yaiZ Escherichia coli IAI1 hypothetical protein YP_002385853.1 410886 D 585034 CDS YP_002385854.1 218552941 7126728 complement(411254..412348) 1 NC_011741.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 412348 ddl 7126728 ddl Escherichia coli IAI1 D-alanyl-alanine synthetase A YP_002385854.1 411254 R 585034 CDS YP_002385855.1 218552942 7124548 412426..412629 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 412629 7124548 ECIAI1_0378 Escherichia coli IAI1 hypothetical protein YP_002385855.1 412426 D 585034 CDS YP_002385856.1 218552943 7127021 complement(412862..413695) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1718819, 7737514; Product type pe : putative enzyme; transposase, ORF B, IS3 family, IS407 group 413695 7127021 ECIAI1_0379 Escherichia coli IAI1 transposase, ORF B, IS3 family, IS407 group YP_002385856.1 412862 R 585034 CDS YP_002385857.1 218552944 7127022 complement(413719..413982) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15126494, 7737514; Product type pe : putative enzyme; transposase, ORF A, IS3 family, IS407 group 413982 7127022 ECIAI1_0380 Escherichia coli IAI1 transposase, ORF A, IS3 family, IS407 group YP_002385857.1 413719 R 585034 CDS YP_002385858.1 218552945 7127023 414057..414296 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 414296 yaiB 7127023 yaiB Escherichia coli IAI1 hypothetical protein YP_002385858.1 414057 D 585034 CDS YP_002385859.1 218552946 7126716 414397..415812 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme; alkaline phosphatase 415812 phoA 7126716 phoA Escherichia coli IAI1 alkaline phosphatase YP_002385859.1 414397 D 585034 CDS YP_002385860.1 218552947 7124214 415931..416251 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3533724, 2160940; Product type f : factor; hypothetical protein 416251 psiF 7124214 psiF Escherichia coli IAI1 hypothetical protein YP_002385860.1 415931 D 585034 CDS YP_002385861.1 218552948 7126173 416353..417468 1 NC_011741.1 catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA 417468 adrA 7126173 adrA Escherichia coli IAI1 diguanylate cyclase AdrA YP_002385861.1 416353 D 585034 CDS YP_002385862.1 218552949 7126717 complement(417485..418294) 1 NC_011741.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 418294 proC 7126717 proC Escherichia coli IAI1 pyrroline-5-carboxylate reductase YP_002385862.1 417485 R 585034 CDS YP_002385863.1 218552950 7126158 418414..418872 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 418872 yaiI 7126158 yaiI Escherichia coli IAI1 hypothetical protein YP_002385863.1 418414 D 585034 CDS YP_002385864.1 218552951 7126719 419055..419579 1 NC_011741.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase II 419579 aroL 7126719 aroL Escherichia coli IAI1 shikimate kinase II YP_002385864.1 419055 D 585034 CDS YP_002385865.1 218552952 7125811 419629..419820 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 419820 yaiA 7125811 yaiA Escherichia coli IAI1 hypothetical protein YP_002385865.1 419629 D 585034 CDS YP_002385866.1 218552953 7126715 420078..420755 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 86085675, 3001025; hypothetical protein 420755 aroM 7126715 aroM Escherichia coli IAI1 hypothetical protein YP_002385866.1 420078 D 585034 CDS YP_002385867.1 218552954 7125812 420827..421111 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 421111 yaiE 7125812 yaiE Escherichia coli IAI1 hypothetical protein YP_002385867.1 420827 D 585034 CDS YP_002385868.1 218552955 7126718 421372..421734 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 421734 7126718 ECIAI1_0392 Escherichia coli IAI1 hypothetical protein YP_002385868.1 421372 D 585034 CDS YP_002385869.1 218552956 7127024 complement(421812..422723) 1 NC_011741.1 Required for efficient pilin antigenic variation; recombination associated protein 422723 rdgC 7127024 rdgC Escherichia coli IAI1 recombination associated protein YP_002385869.1 421812 R 585034 CDS YP_002385870.1 218552957 7126603 422848..423756 1 NC_011741.1 catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 423756 mak 7126603 mak Escherichia coli IAI1 fructokinase YP_002385870.1 422848 D 585034 CDS YP_002385871.1 218552958 7127653 complement(423899..425083) 1 NC_011741.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ 425083 araJ 7127653 araJ Escherichia coli IAI1 MFS transport protein AraJ YP_002385871.1 423899 R 585034 CDS YP_002385872.1 218552959 7125783 complement(425209..428352) 1 NC_011741.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease subunit SbcC 428352 sbcC 7125783 sbcC Escherichia coli IAI1 exonuclease subunit SbcC YP_002385872.1 425209 R 585034 CDS YP_002385873.1 218552960 7124676 complement(428349..429551) 1 NC_011741.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease subunit SbcD 429551 sbcD 7124676 sbcD Escherichia coli IAI1 exonuclease subunit SbcD YP_002385873.1 428349 R 585034 CDS YP_002385874.1 218552961 7124677 429741..430430 1 NC_011741.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 430430 phoB 7124677 phoB Escherichia coli IAI1 transcriptional regulator PhoB YP_002385874.1 429741 D 585034 CDS YP_002385875.1 218552962 7124215 430488..431783 1 NC_011741.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 431783 phoR 7124215 phoR Escherichia coli IAI1 phosphate regulon sensor protein YP_002385875.1 430488 D 585034 CDS YP_002385876.1 218552963 7124220 complement(431794..431904) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 431904 7124220 ECIAI1_0400 Escherichia coli IAI1 hypothetical protein YP_002385876.1 431794 R 585034 CDS YP_002385877.1 218552964 7127025 432190..433509 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3078876, 6998958, 3550103, 7984428; Product type t : transporter; branched chain amino acid transporter 433509 brnQ 7127025 brnQ Escherichia coli IAI1 branched chain amino acid transporter YP_002385877.1 432190 D 585034 CDS YP_002385878.1 218552965 7124420 433585..434958 1 NC_011741.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; putative proline-specific permease 434958 proY 7124420 proY Escherichia coli IAI1 putative proline-specific permease YP_002385878.1 433585 D 585034 CDS YP_002385879.1 218552966 7126165 435114..436931 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92184757, 1706703, 1918057; Product type e : enzyme; maltodextrin glucosidase 436931 malZ 7126165 malZ Escherichia coli IAI1 maltodextrin glucosidase YP_002385879.1 435114 D 585034 CDS YP_002385880.1 218552967 7127666 complement(436936..437517) 1 NC_011741.1 Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; acyl carrier protein phosphodiesterase 437517 acpH 7127666 acpH Escherichia coli IAI1 acyl carrier protein phosphodiesterase YP_002385880.1 436936 R 585034 CDS YP_002385881.1 218552968 7125702 437610..438680 1 NC_011741.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 438680 queA 7125702 queA Escherichia coli IAI1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase YP_002385881.1 437610 D 585034 CDS YP_002385882.1 218552969 7126582 438736..439863 1 NC_011741.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 439863 tgt 7126582 tgt Escherichia coli IAI1 queuine tRNA-ribosyltransferase YP_002385882.1 438736 D 585034 CDS YP_002385883.1 218552970 7126239 439886..440218 1 NC_011741.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 440218 yajC 7126239 yajC Escherichia coli IAI1 preprotein translocase subunit YajC YP_002385883.1 439886 D 585034 CDS YP_002385884.1 218552971 7126729 440246..442093 1 NC_011741.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 442093 secD 7126729 secD Escherichia coli IAI1 preprotein translocase subunit SecD YP_002385884.1 440246 D 585034 CDS YP_002385885.1 218552972 7124693 442104..443075 1 NC_011741.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 443075 secF 7124693 secF Escherichia coli IAI1 preprotein translocase subunit SecF YP_002385885.1 442104 D 585034 CDS YP_002385886.1 218552973 7124695 443204..443551 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 443551 yajD 7124695 yajD Escherichia coli IAI1 hypothetical protein YP_002385886.1 443204 D 585034 CDS YP_002385887.1 218552974 7126730 complement(443728..444612) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91092502, 91358319, 93352541; Product type m : membrane component; nucleoside channel phage T6/colicin K receptor 444612 tsx 7126730 tsx Escherichia coli IAI1 nucleoside channel phage T6/colicin K receptor YP_002385887.1 443728 R 585034 CDS YP_002385888.1 218552975 7127512 complement(444911..445450) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 445450 yajI 7127512 yajI Escherichia coli IAI1 hypothetical protein YP_002385888.1 444911 R 585034 CDS YP_002385889.1 218552976 7126732 445601..446050 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator NrdR 446050 nrdR 7126732 nrdR Escherichia coli IAI1 transcriptional regulator NrdR YP_002385889.1 445601 D 585034 CDS YP_002385890.1 218552977 7125941 446054..447157 1 NC_011741.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 447157 ribD 7125941 ribD Escherichia coli IAI1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase YP_002385890.1 446054 D 585034 CDS YP_002385891.1 218552978 7124995 447246..447716 1 NC_011741.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 447716 ribH 7124995 ribH Escherichia coli IAI1 6,7-dimethyl-8-ribityllumazine synthase YP_002385891.1 447246 D 585034 CDS YP_002385892.1 218552979 7124996 447736..448155 1 NC_011741.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 448155 nusB 7124996 nusB Escherichia coli IAI1 transcription antitermination protein NusB YP_002385892.1 447736 D 585034 CDS YP_002385893.1 218552980 7125974 448233..449210 1 NC_011741.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 449210 thiL 7125974 thiL Escherichia coli IAI1 thiamine monophosphate kinase YP_002385893.1 448233 D 585034 CDS YP_002385894.1 218552981 7126247 449188..449706 1 NC_011741.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 449706 pgpA 7126247 pgpA Escherichia coli IAI1 phosphatidylglycerophosphatase A YP_002385894.1 449188 D 585034 CDS YP_002385895.1 218552982 7124189 complement(449760..450734) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217, 16077126; Product type e : enzyme; aldoketo-oxidoreductase 450734 yajO 7124189 yajO Escherichia coli IAI1 aldoketo-oxidoreductase YP_002385895.1 449760 R 585034 CDS YP_002385896.1 218552983 7126734 complement(450789..452651) 1 NC_011741.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 452651 dxs 7126734 dxs Escherichia coli IAI1 1-deoxy-D-xylulose-5-phosphate synthase YP_002385896.1 450789 R 585034 CDS YP_002385897.1 218552984 7125036 complement(452676..453575) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89291702, 91210228; Product type e : enzyme; geranyltranstransferase 453575 ispA 7125036 ispA Escherichia coli IAI1 geranyltranstransferase YP_002385897.1 452676 R 585034 CDS YP_002385898.1 218552985 7126079 complement(453575..453817) 1 NC_011741.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 453817 xseB 7126079 xseB Escherichia coli IAI1 exodeoxyribonuclease VII small subunit YP_002385898.1 453575 R 585034 CDS YP_002385899.1 218552986 7126475 454023..455471 1 NC_011741.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 455471 thiI 7126475 thiI Escherichia coli IAI1 thiamine biosynthesis protein ThiI YP_002385899.1 454023 D 585034 CDS YP_002385900.1 218552987 7126246 complement(455525..456115) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 97039868, 99173753, 99311269; DJ-1 family protein 456115 yajL 7126246 yajL Escherichia coli IAI1 DJ-1 family protein YP_002385900.1 455525 R 585034 CDS YP_002385901.1 218552988 7126733 complement(456078..456989) 1 NC_011741.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 456989 panE 7126733 panE Escherichia coli IAI1 2-dehydropantoate 2-reductase YP_002385901.1 456078 R 585034 CDS YP_002385902.1 218552989 7124153 457157..457648 1 NC_011741.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; putative nucleotide-binding protein 457648 yajQ 7124153 yajQ Escherichia coli IAI1 putative nucleotide-binding protein YP_002385902.1 457157 D 585034 CDS YP_002385903.1 218552990 7126735 complement(457776..459140) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 459140 yajR 7126735 yajR Escherichia coli IAI1 putative MFS superfamily transporter YP_002385903.1 457776 R 585034 CDS YP_002385904.1 218552991 7126736 459488..460483 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative zinc-dependent hydrolase 460483 7126736 ECIAI1_0428 Escherichia coli IAI1 putative zinc-dependent hydrolase YP_002385904.1 459488 D 585034 CDS YP_002385905.1 218552992 7127026 complement(460539..461081) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase 461081 7127026 ECIAI1_0429 Escherichia coli IAI1 putative acetyltransferase YP_002385905.1 460539 R 585034 CDS YP_002385906.1 218552993 7127027 complement(461065..461442) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 461442 7127027 ECIAI1_0430 Escherichia coli IAI1 hypothetical protein YP_002385906.1 461065 R 585034 CDS YP_002385907.1 218552994 7127028 complement(461561..462451) 1 NC_011741.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 462451 cyoE 7127028 cyoE Escherichia coli IAI1 protoheme IX farnesyltransferase YP_002385907.1 461561 R 585034 CDS YP_002385908.1 218552995 7126886 complement(462463..462792) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 90366572, 92345252, 9378722, 98021084, 11017202, 2162835; Product type c : carrier; cytochrome o ubiquinol oxidase subunit IV 462792 cyoD 7126886 cyoD Escherichia coli IAI1 cytochrome o ubiquinol oxidase subunit IV YP_002385908.1 462463 R 585034 CDS YP_002385909.1 218552996 7126885 complement(462792..463406) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 92345252, 93349845, 9378722, 98021084, 11017202, 2162835, 2168206; Product type c : carrier; cytochrome o ubiquinol oxidase subunit III 463406 cyoC 7126885 cyoC Escherichia coli IAI1 cytochrome o ubiquinol oxidase subunit III YP_002385909.1 462792 R 585034 CDS YP_002385910.1 218552997 7126884 complement(463396..465387) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 92345252, 93349845, 9378722, 98021084, 11017202, 2162835, 2168206; Product type c : carrier; cytochrome o ubiquinol oxidase subunit I 465387 cyoB 7126884 cyoB Escherichia coli IAI1 cytochrome o ubiquinol oxidase subunit I YP_002385910.1 463396 R 585034 CDS YP_002385911.1 218552998 7126883 complement(465409..466356) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92112945, 92371427, 9378722, 98021084, 11017202, 1322173, 2162835, 2162837, 2165491, 2168206, 8231804, 8618822; Product type c : carrier; cytochrome o ubiquinol oxidase subunit II 466356 cyoA 7126883 cyoA Escherichia coli IAI1 cytochrome o ubiquinol oxidase subunit II YP_002385911.1 465409 R 585034 CDS YP_002385912.1 218552999 7126882 complement(466816..468291) 1 NC_011741.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter 468291 ampG 7126882 ampG Escherichia coli IAI1 muropeptide transporter YP_002385912.1 466816 R 585034 CDS YP_002385913.1 218553000 7125759 complement(468335..468913) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 468913 yajG 7125759 yajG Escherichia coli IAI1 hypothetical protein YP_002385913.1 468335 R 585034 CDS YP_002385914.1 218553001 7126731 469218..469535 1 NC_011741.1 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA 469535 bolA 7126731 bolA Escherichia coli IAI1 transcriptional regulator BolA YP_002385914.1 469218 D 585034 CDS YP_002385915.1 218553002 7124418 469469..469732 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 469732 7124418 ECIAI1_0439 Escherichia coli IAI1 hypothetical protein YP_002385915.1 469469 D 585034 CDS YP_002385916.1 218553003 7127029 469879..471177 1 NC_011741.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 471177 tig 7127029 tig Escherichia coli IAI1 trigger factor YP_002385916.1 469879 D 585034 CDS YP_002385917.1 218553004 7126259 471423..472046 1 NC_011741.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 472046 clpP 7126259 clpP Escherichia coli IAI1 ATP-dependent Clp protease proteolytic subunit YP_002385917.1 471423 D 585034 CDS YP_002385918.1 218553005 7126334 472172..473446 1 NC_011741.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 473446 clpX 7126334 clpX Escherichia coli IAI1 ATP-dependent protease ATP-binding subunit ClpX YP_002385918.1 472172 D 585034 CDS YP_002385919.1 218553006 7127967 473634..475988 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10094703, 14665623, 8939438, 91072263, 97137085, 2984174, 3042779, 3289547, 7988699, 8226758, 8294008; Product type e : enzyme; DNA-binding ATP-dependent protease La 475988 lon 7127967 lon Escherichia coli IAI1 DNA-binding ATP-dependent protease La YP_002385919.1 473634 D 585034 CDS YP_002385920.1 218553007 7126438 476197..476469 1 NC_011741.1 histone-like DNA-binding protein; transcriptional regulator HU subunit beta 476469 hupB 7126438 hupB Escherichia coli IAI1 transcriptional regulator HU subunit beta YP_002385920.1 476197 D 585034 CDS YP_002385921.1 218553008 7125325 476661..478532 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9670013; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase 478532 ppiD 7125325 ppiD Escherichia coli IAI1 peptidyl-prolyl cis-trans isomerase YP_002385921.1 476661 D 585034 CDS YP_002385922.1 218553009 7126135 478683..479054 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 479054 ybaV 7126135 ybaV Escherichia coli IAI1 hypothetical protein YP_002385922.1 478683 D 585034 CDS YP_002385923.1 218553010 7126750 479160..479558 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 479558 ybaW 7126750 ybaW Escherichia coli IAI1 hypothetical protein YP_002385923.1 479160 D 585034 CDS YP_002385924.1 218553011 7126751 complement(479610..480305) 1 NC_011741.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC 480305 queC 7126751 queC Escherichia coli IAI1 queuosine biosynthesis protein QueC YP_002385924.1 479610 R 585034 CDS YP_002385925.1 218553012 7126583 complement(480370..482070) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 482070 ybaE 7126583 ybaE Escherichia coli IAI1 hypothetical protein YP_002385925.1 480370 R 585034 CDS YP_002385926.1 218553013 7126739 482170..482988 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217; Product type e : enzyme; thiamin pyrimidine pyrophosphate hydrolase 482988 cof 7126739 cof Escherichia coli IAI1 thiamin pyrimidine pyrophosphate hydrolase YP_002385926.1 482170 D 585034 CDS YP_002385927.1 218553014 7126351 482988..483599 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator (Lrp-like) 483599 ybaO 7126351 ybaO Escherichia coli IAI1 putative DNA-binding transcriptional regulator (Lrp-like) YP_002385927.1 482988 D 585034 CDS YP_002385928.1 218553015 7126745 483629..485401 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 94124004, 10850996; Product type pt : putative transporter; putative multidrug transporter membrane/ATP-binding protein 485401 mdlA 7126745 mdlA Escherichia coli IAI1 putative multidrug transporter membrane/ATP-binding protein YP_002385928.1 483629 D 585034 CDS YP_002385929.1 218553016 7127681 485394..487175 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 94124004; Product type pt : putative transporter; putative multidrug transporter membrane/ATP-binding protein 487175 mdlB 7127681 mdlB Escherichia coli IAI1 putative multidrug transporter membrane/ATP-binding protein YP_002385929.1 485394 D 585034 CDS YP_002385930.1 218553017 7127682 487356..487694 1 NC_011741.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 487694 glnK 7127682 glnK Escherichia coli IAI1 nitrogen regulatory protein P-II 2 YP_002385930.1 487356 D 585034 CDS YP_002385931.1 218553018 7128327 487724..489010 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22020597, 9618533, 10931328, 1645722, 7984428; Product type t : transporter; ammonium transporter 489010 amtB 7128327 amtB Escherichia coli IAI1 ammonium transporter YP_002385931.1 487724 D 585034 CDS YP_002385932.1 218553019 7125761 complement(489059..489919) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86139906, 91250410, 10876240; Product type e : enzyme; acyl-CoA thioesterase II 489919 tesB 7125761 tesB Escherichia coli IAI1 acyl-CoA thioesterase II YP_002385932.1 489059 R 585034 CDS YP_002385933.1 218553020 7126237 490137..490709 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 490709 ybaY 7126237 ybaY Escherichia coli IAI1 hypothetical protein YP_002385933.1 490137 D 585034 CDS YP_002385934.1 218553021 7126752 complement(490740..491129) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methylated DNA-protein cysteine alkyltransferase 491129 ybaZ 7126752 ybaZ Escherichia coli IAI1 putative methylated DNA-protein cysteine alkyltransferase YP_002385934.1 490740 R 585034 CDS YP_002385935.1 218553022 7127095 491430..491783 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 491783 ybaA 7127095 ybaA Escherichia coli IAI1 hypothetical protein YP_002385935.1 491430 D 585034 CDS YP_002385936.1 218553023 7126737 complement(491825..493375) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 493375 ylaB 7126737 ylaB Escherichia coli IAI1 hypothetical protein YP_002385936.1 491825 R 585034 CDS YP_002385937.1 218553024 7126655 complement(493539..494009) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 494009 ylaC 7126655 ylaC Escherichia coli IAI1 hypothetical protein YP_002385937.1 493539 R 585034 CDS YP_002385938.1 218553025 7126656 complement(494125..494676) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82180540, 91310703, 9600841; Product type e : enzyme; maltose O-acetyltransferase 494676 maa 7126656 maa Escherichia coli IAI1 maltose O-acetyltransferase YP_002385938.1 494125 R 585034 CDS YP_002385939.1 218553026 7127649 complement(494847..495065) 1 NC_011741.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein 495065 hha 7127649 hha Escherichia coli IAI1 hemolysin expression-modulating protein YP_002385939.1 494847 R 585034 CDS YP_002385940.1 218553027 7128524 complement(495091..495465) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1956303, 7984428, 14645275; hypothetical protein 495465 ybaJ 7128524 ybaJ Escherichia coli IAI1 hypothetical protein YP_002385940.1 495091 R 585034 CDS YP_002385941.1 218553028 7126740 complement(496011..499160) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12351840, 12654283, 15111118, 15155734, 21450803, 94012493, 10920254, 7651136; Product type t : transporter; multidrug efflux system protein 499160 acrB 7126740 acrB Escherichia coli IAI1 multidrug efflux system protein YP_002385941.1 496011 R 585034 CDS YP_002385942.1 218553029 7125707 complement(499183..500376) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15155734, 21450803, 383699, 390095, 94012493, 10920254, 7651136; Product type t : transporter; multidrug efflux system 500376 acrA 7125707 acrA Escherichia coli IAI1 multidrug efflux system YP_002385942.1 499183 R 585034 CDS YP_002385943.1 218553030 7125706 500518..501165 1 NC_011741.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR 501165 acrR 7125706 acrR Escherichia coli IAI1 DNA-binding transcriptional repressor AcrR YP_002385943.1 500518 D 585034 CDS YP_002385944.1 218553031 7125711 501293..504655 1 NC_011741.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 504655 kefA 7125711 kefA Escherichia coli IAI1 potassium efflux protein KefA YP_002385944.1 501293 D 585034 CDS YP_002385945.1 218553032 7126385 complement(504867..505028) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 505028 ybaM 7126385 ybaM Escherichia coli IAI1 hypothetical protein YP_002385945.1 504867 R 585034 CDS YP_002385946.1 218553033 7126743 complement(505042..505569) 1 NC_011741.1 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' 505569 priC 7126743 priC Escherichia coli IAI1 primosomal replication protein N'' YP_002385946.1 505042 R 585034 CDS YP_002385947.1 218553034 7126150 505639..506016 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 506016 ybaN 7126150 ybaN Escherichia coli IAI1 hypothetical protein YP_002385947.1 505639 D 585034 CDS YP_002385948.1 218553035 7126744 506169..506720 1 NC_011741.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 506720 apt 7126744 apt Escherichia coli IAI1 adenine phosphoribosyltransferase YP_002385948.1 506169 D 585034 CDS YP_002385949.1 218553036 7125773 506849..508780 1 NC_011741.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 508780 dnaX 7125773 dnaX Escherichia coli IAI1 DNA polymerase III subunits gamma and tau YP_002385949.1 506849 D 585034 CDS YP_002385950.1 218553037 7124614 508833..509162 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15322138, 1698765, 2674903; hypothetical protein 509162 ybaB 7124614 ybaB Escherichia coli IAI1 hypothetical protein YP_002385950.1 508833 D 585034 CDS YP_002385951.1 218553038 7126738 509162..509767 1 NC_011741.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 509767 recR 7126738 recR Escherichia coli IAI1 recombination protein RecR YP_002385951.1 509162 D 585034 CDS YP_002385952.1 218553039 7124955 509877..511751 1 NC_011741.1 molecular chaperone; heat shock protein 90 511751 htpG 7124955 htpG Escherichia coli IAI1 heat shock protein 90 YP_002385952.1 509877 D 585034 CDS YP_002385953.1 218553040 7125318 511932..512576 1 NC_011741.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 512576 adk 7125318 adk Escherichia coli IAI1 adenylate kinase YP_002385953.1 511932 D 585034 CDS YP_002385954.1 218553041 7125722 512708..513670 1 NC_011741.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 513670 hemH 7125722 hemH Escherichia coli IAI1 ferrochelatase YP_002385954.1 512708 D 585034 CDS YP_002385955.1 218553042 7128512 complement(513667..514626) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9401025, 98244813, 2051480, 7721718; Product type e : enzyme; acetyl esterase 514626 aes 7128512 aes Escherichia coli IAI1 acetyl esterase YP_002385955.1 513667 R 585034 CDS YP_002385956.1 218553043 7125726 514778..516082 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90155203, 95238302, 2051480; Product type e : enzyme; inosine/guanosine kinase 516082 gsk 7125726 gsk Escherichia coli IAI1 inosine/guanosine kinase YP_002385956.1 514778 D 585034 CDS YP_002385957.1 218553044 7128473 complement(516215..517891) 1 NC_011741.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; putative cation:proton antiport protein 517891 ybaL 7128473 ybaL Escherichia coli IAI1 putative cation:proton antiport protein YP_002385957.1 516215 R 585034 CDS YP_002385958.1 218553045 7126742 complement(518129..519349) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 97074653, 8917080; Product type t : transporter; fosmidomycin efflux systemprotein 519349 fsr 7126742 fsr Escherichia coli IAI1 fosmidomycin efflux systemprotein YP_002385958.1 518129 R 585034 CDS YP_002385959.1 218553046 7128230 519567..521219 1 NC_011741.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic 521219 ushA 7128230 ushA Escherichia coli IAI1 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic YP_002385959.1 519567 D 585034 CDS YP_002385960.1 218553047 7124649 complement(521256..521735) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 521735 ybaK 7124649 ybaK Escherichia coli IAI1 hypothetical protein YP_002385960.1 521256 R 585034 CDS YP_002385961.1 218553048 7127977 complement(521939..522733) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 522733 ybaP 7127977 ybaP Escherichia coli IAI1 hypothetical protein YP_002385961.1 521939 R 585034 CDS YP_002385962.1 218553049 7126746 522871..523212 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 523212 ybaQ 7126746 ybaQ Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002385962.1 522871 D 585034 CDS YP_002385963.1 218553050 7126747 complement(523326..525830) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12351646, 20105527, 11167016, 11500054, 9868784; Product type t : transporter; copper exporting ATPase 525830 copA 7126747 copA Escherichia coli IAI1 copper exporting ATPase YP_002385963.1 523326 R 585034 CDS YP_002385964.1 218553051 7126352 526092..527024 1 NC_011741.1 catalyzes the formation of glutamate from glutamine; glutaminase 527024 ybaS 7126352 ybaS Escherichia coli IAI1 glutaminase YP_002385964.1 526092 D 585034 CDS YP_002385965.1 218553052 7126748 527027..528319 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative nitrogen-containing metabolite transporter 528319 ybaT 7126748 ybaT Escherichia coli IAI1 putative nitrogen-containing metabolite transporter YP_002385965.1 527027 D 585034 CDS YP_002385966.1 218553053 7126749 528444..528851 1 NC_011741.1 activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR 528851 cueR 7126749 cueR Escherichia coli IAI1 DNA-binding transcriptional regulator CueR YP_002385966.1 528444 D 585034 CDS YP_002385967.1 218553054 7126858 complement(528852..529307) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 529307 ybbJ 7126858 ybbJ Escherichia coli IAI1 hypothetical protein YP_002385967.1 528852 R 585034 CDS YP_002385968.1 218553055 7126757 complement(529307..530224) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative protease, membrane anchored 530224 ybbK 7126757 ybbK Escherichia coli IAI1 putative protease, membrane anchored YP_002385968.1 529307 R 585034 CDS YP_002385969.1 218553056 7126758 530370..531047 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein YbbL 531047 ybbL 7126758 ybbL Escherichia coli IAI1 putative ABC transporter ATP-binding protein YbbL YP_002385969.1 530370 D 585034 CDS YP_002385970.1 218553057 7126759 531034..531813 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative ABC transporter permease 531813 ybbM 7126759 ybbM Escherichia coli IAI1 putative ABC transporter permease YP_002385970.1 531034 D 585034 CDS YP_002385971.1 218553058 7126760 complement(531876..532730) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative thioredoxin domain-containing protein 532730 ybbN 7126760 ybbN Escherichia coli IAI1 putative thioredoxin domain-containing protein YP_002385971.1 531876 R 585034 CDS YP_002385972.1 218553059 7126761 complement(532791..533600) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; short chain dehydrogenase 533600 ybbO 7126761 ybbO Escherichia coli IAI1 short chain dehydrogenase YP_002385972.1 532791 R 585034 CDS YP_002385973.1 218553060 7126762 complement(533590..534216) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91270121, 91324311, 93163029, 93252782, 94179121, 99353977, 1864840, 8432696, 8098033; Product type e : enzyme; multifunctional acyl-CoA thioesterase I and protease I and lysophospholipase L1 534216 tesA 7126762 tesA Escherichia coli IAI1 multifunctional acyl-CoA thioesterase I and protease I and lysophospholipase L1 YP_002385973.1 533590 R 585034 CDS YP_002385974.1 218553061 7126236 534184..534870 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein YbbA 534870 ybbA 7126236 ybbA Escherichia coli IAI1 putative ABC transporter ATP-binding protein YbbA YP_002385974.1 534184 D 585034 CDS YP_002385975.1 218553062 7126754 534867..537281 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type t : transporter; putative ABC transporter permease 537281 ybbP 7126754 ybbP Escherichia coli IAI1 putative ABC transporter permease YP_002385975.1 534867 D 585034 CDS YP_002385976.1 218553063 7126763 537711..542000 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 98361897, 1766878, 2403547, 2644231, 7934896; Product type h : extrachromosomal origin; rhsD element protein 542000 rhsD 7126763 rhsD Escherichia coli IAI1 rhsD element protein YP_002385976.1 537711 D 585034 CDS YP_002385977.1 218553064 7124987 542040..542408 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 542408 ybbC 7124987 ybbC Escherichia coli IAI1 hypothetical protein YP_002385977.1 542040 D 585034 CDS YP_002385978.1 218553065 7126756 542408..543118 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1766878, 7934896; Product type h : extrachromosomal origin; hypothetical protein 543118 ylbH 7126756 ylbH Escherichia coli IAI1 hypothetical protein YP_002385978.1 542408 D 585034 CDS YP_002385979.1 218553066 7127030 complement(543876..544091) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 544091 7127030 ECIAI1_0504 Escherichia coli IAI1 hypothetical protein YP_002385979.1 543876 R 585034 CDS YP_002385980.1 218553067 7127031 complement(544078..544512) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative regulator with homeodomain-like DNA binding domain 544512 7127031 ECIAI1_0505 Escherichia coli IAI1 putative regulator with homeodomain-like DNA binding domain YP_002385980.1 544078 R 585034 CDS YP_002385981.1 218553068 7127032 complement(544592..545686) 1 NC_011741.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase 545686 ybbB 7127032 ybbB Escherichia coli IAI1 tRNA 2-selenouridine synthase YP_002385981.1 544592 R 585034 CDS YP_002385982.1 218553069 7126755 complement(545755..546681) 1 NC_011741.1 activator of the allDC-ylbA operon involved in allantoin utilization; DNA-binding transcriptional activator AllS 546681 ybbS 7126755 ybbS Escherichia coli IAI1 DNA-binding transcriptional activator AllS YP_002385982.1 545755 R 585034 CDS YP_002385983.1 218553070 7126764 546911..547393 1 NC_011741.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 547393 allA 7126764 allA Escherichia coli IAI1 ureidoglycolate hydrolase YP_002385983.1 546911 D 585034 CDS YP_002385984.1 218553071 7125745 547471..548286 1 NC_011741.1 regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR 548286 allR 7125745 allR Escherichia coli IAI1 DNA-binding transcriptional repressor AllR YP_002385984.1 547471 D 585034 CDS YP_002385985.1 218553072 7125749 548376..550157 1 NC_011741.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 550157 gcl 7125749 gcl Escherichia coli IAI1 glyoxylate carboligase YP_002385985.1 548376 D 585034 CDS YP_002385986.1 218553073 7128292 550170..550946 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20029625, 8440684; Product type e : enzyme; hydroxypyruvate isomerase 550946 hyi 7128292 hyi Escherichia coli IAI1 hydroxypyruvate isomerase YP_002385986.1 550170 D 585034 CDS YP_002385987.1 218553074 7126028 551046..551924 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20069628; Product type e : enzyme; tartronate semialdehyde reductase, NADH-dependent 551924 glxR 7126028 glxR Escherichia coli IAI1 tartronate semialdehyde reductase, NADH-dependent YP_002385987.1 551046 D 585034 CDS YP_002385988.1 218553075 7128357 552093..553547 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1293888; Product type t : transporter; allantoin permease 553547 ybbW 7128357 ybbW Escherichia coli IAI1 allantoin permease YP_002385988.1 552093 D 585034 CDS YP_002385989.1 218553076 7126765 553607..554968 1 NC_011741.1 Plays a crucial role on both purine and pyrimidine metabolism; allantoinase 554968 allB 7126765 allB Escherichia coli IAI1 allantoinase YP_002385989.1 553607 D 585034 CDS YP_002385990.1 218553077 7125746 555025..556326 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative purine permease YbbY 556326 ybbY 7125746 ybbY Escherichia coli IAI1 putative purine permease YbbY YP_002385990.1 555025 D 585034 CDS YP_002385991.1 218553078 7126766 556348..557493 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20069628; Product type e : enzyme; glycerate kinase II 557493 glxK 7126766 glxK Escherichia coli IAI1 glycerate kinase II YP_002385991.1 556348 D 585034 CDS YP_002385992.1 218553079 7128356 complement(557622..558407) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 558407 ylbA 7128356 ylbA Escherichia coli IAI1 hypothetical protein YP_002385992.1 557622 R 585034 CDS YP_002385993.1 218553080 7126657 complement(558418..559653) 1 NC_011741.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase 559653 allC 7126657 allC Escherichia coli IAI1 allantoate amidohydrolase YP_002385993.1 558418 R 585034 CDS YP_002385994.1 218553081 7125747 complement(559675..560724) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12460564, 20069628, 69151449; Product type e : enzyme; ureidoglycolate dehydrogenase 560724 allD 7125747 allD Escherichia coli IAI1 ureidoglycolate dehydrogenase YP_002385994.1 559675 R 585034 CDS YP_002385995.1 218553082 7125748 561041..562708 1 NC_011741.1 multicopy suppressor of dominant negative ftsH mutations; membrane protein FdrA 562708 fdrA 7125748 fdrA Escherichia coli IAI1 membrane protein FdrA YP_002385995.1 561041 D 585034 CDS YP_002385996.1 218553083 7127081 562718..563977 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 563977 ylbE 7127081 ylbE Escherichia coli IAI1 hypothetical protein YP_002385996.1 562718 D 585034 CDS YP_002385997.1 218553084 7126658 563988..564803 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 564803 ylbF 7126658 ylbF Escherichia coli IAI1 hypothetical protein YP_002385997.1 563988 D 585034 CDS YP_002385998.1 218553085 7126659 564800..565693 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2464576, 2644189, 7920643, 7940673, 7984428; Product type pe : putative enzyme; carbamate kinase 565693 ybcF 7126659 ybcF Escherichia coli IAI1 carbamate kinase YP_002385998.1 564800 D 585034 CDS YP_002385999.1 218553086 7126767 complement(565830..566897) 1 NC_011741.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 566897 purK 7126767 purK Escherichia coli IAI1 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_002385999.1 565830 R 585034 CDS YP_002386000.1 218553087 7126551 complement(566894..567403) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10074353, 8117684, 89123018, 89123019, 92287929, 10574791; Product type e : enzyme; N5-carboxyaminoimidazole ribonucleotide mutase 567403 purE 7126551 purE Escherichia coli IAI1 N5-carboxyaminoimidazole ribonucleotide mutase YP_002386000.1 566894 R 585034 CDS YP_002386001.1 218553088 7126548 complement(567521..568243) 1 NC_011741.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 568243 lpxH 7126548 lpxH Escherichia coli IAI1 UDP-2,3-diacylglucosamine hydrolase YP_002386001.1 567521 R 585034 CDS YP_002386002.1 218553089 7127626 complement(568246..568740) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90272647, 91175755, 1606970, 1864365, 8601841, 9298646, 9600841; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase B 568740 ppiB 7127626 ppiB Escherichia coli IAI1 peptidyl-prolyl cis-trans isomerase B YP_002386002.1 568246 R 585034 CDS YP_002386003.1 218553090 7126133 568914..570299 1 NC_011741.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 570299 cysS 7126133 cysS Escherichia coli IAI1 cysteinyl-tRNA synthetase YP_002386003.1 568914 D 585034 CDS YP_002386004.1 218553091 7126901 complement(570335..570856) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 570856 ybcI 7126901 ybcI Escherichia coli IAI1 hypothetical protein YP_002386004.1 570335 R 585034 CDS YP_002386005.1 218553092 7127369 complement(570964..571176) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12837795, 1748668, 7567469; Product type pr : putative regulator; hypothetical protein 571176 ybcJ 7127369 ybcJ Escherichia coli IAI1 hypothetical protein YP_002386005.1 570964 R 585034 CDS YP_002386006.1 218553093 7124782 complement(571178..572044) 1 NC_011741.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 572044 folD 7124782 folD Escherichia coli IAI1 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_002386006.1 571178 R 585034 CDS YP_002386007.1 218553094 7127262 572525..573067 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2890624; Product type ps : putative structure; putative fimbrial-like adhesin protein 573067 sfmA 7127262 sfmA Escherichia coli IAI1 putative fimbrial-like adhesin protein YP_002386007.1 572525 D 585034 CDS YP_002386008.1 218553095 7127916 573287..573979 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15372038, 2553674; Product type f : factor; pilin chaperone, periplasmic 573979 sfmC 7127916 sfmC Escherichia coli IAI1 pilin chaperone, periplasmic YP_002386008.1 573287 D 585034 CDS YP_002386009.1 218553096 7127917 574010..576619 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1970114; Product type pf : putative factor; putative outer membrane export usher protein 576619 sfmD 7127917 sfmD Escherichia coli IAI1 putative outer membrane export usher protein YP_002386009.1 574010 D 585034 CDS YP_002386010.1 218553097 7127918 576662..577639 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein 577639 sfmH 7127918 sfmH Escherichia coli IAI1 putative fimbrial-like adhesin protein YP_002386010.1 576662 D 585034 CDS YP_002386011.1 218553098 7127920 577650..578165 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2890624; Product type ps : putative structure; putative fimbrial protein 578165 sfmF 7127920 sfmF Escherichia coli IAI1 putative fimbrial protein YP_002386011.1 577650 D 585034 CDS YP_002386012.1 218553099 7127919 complement(578168..578800) 1 NC_011741.1 activates the production of the major fimbrae protein FimA; transcriptional regulator FimZ 578800 fimZ 7127919 fimZ Escherichia coli IAI1 transcriptional regulator FimZ YP_002386012.1 578168 R 585034 CDS YP_002386013.1 218553100 7128049 complement(579049..579171) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 579171 7128049 ECIAI1_0538 Escherichia coli IAI1 hypothetical protein YP_002386013.1 579049 R 585034 CDS YP_002386014.1 218553101 7127033 complement(579165..579926) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6317653, 2536924; Product type r : regulator; DNA-binding transcriptional activator of porin biosynthesis 579926 envY 7127033 envY Escherichia coli IAI1 DNA-binding transcriptional activator of porin biosynthesis YP_002386014.1 579165 R 585034 CDS YP_002386015.1 218553102 7125076 complement(580109..580999) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 580999 ybcH 7125076 ybcH Escherichia coli IAI1 hypothetical protein YP_002386015.1 580109 R 585034 CDS YP_002386016.1 218553103 7126768 complement(581000..583972) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89359086, 94042873, 94042874; Product type m : membrane component; bacteriophage N4 receptor, outer membrane subunit 583972 nfrA 7126768 nfrA Escherichia coli IAI1 bacteriophage N4 receptor, outer membrane subunit YP_002386016.1 581000 R 585034 CDS YP_002386017.1 218553104 7127870 complement(583959..586196) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89359086, 94042873, 94042874; Product type m : membrane component; bacteriophage N4 adsorption protein B 586196 nfrB 7127870 nfrB Escherichia coli IAI1 bacteriophage N4 adsorption protein B YP_002386017.1 583959 R 585034 CDS YP_002386018.1 218553105 7127871 complement(586465..587601) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype; putative transposase 587601 yhhI 7127871 yhhI Escherichia coli IAI1 putative transposase YP_002386018.1 586465 R 585034 CDS YP_002386019.1 218553106 7127143 complement(588095..588562) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 588562 7127143 ECIAI1_0545 Escherichia coli IAI1 hypothetical protein YP_002386019.1 588095 R 585034 CDS YP_002386020.1 218553107 7127034 complement(588837..589235) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 589235 7127034 ECIAI1_0546 Escherichia coli IAI1 hypothetical protein YP_002386020.1 588837 R 585034 CDS YP_002386021.1 218553108 7127035 complement(589204..594003) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1766878, 2644231, 2403547, 7934896; Rhs core protein with extension 594003 7127035 ECIAI1_0547 Escherichia coli IAI1 Rhs core protein with extension YP_002386021.1 589204 R 585034 CDS YP_002386022.1 218553109 7127036 complement(594023..594484) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 594484 7127036 ECIAI1_0548 Escherichia coli IAI1 hypothetical protein YP_002386022.1 594023 R 585034 CDS YP_002386023.1 218553110 7127037 complement(594512..596413) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9696756, 8557353; putative Rhs element Vgr protein 596413 7127037 ECIAI1_0549 Escherichia coli IAI1 putative Rhs element Vgr protein YP_002386023.1 594512 R 585034 CDS YP_002386024.1 218553111 7127038 complement(597150..598610) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 11283292, 11399769; Product type r : regulator; sensor kinase CusS 598610 cusS 7127038 cusS Escherichia coli IAI1 sensor kinase CusS YP_002386024.1 597150 R 585034 CDS YP_002386025.1 218553112 7126864 complement(598588..599271) 1 NC_011741.1 response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR 599271 cusR 7126864 cusR Escherichia coli IAI1 DNA-binding transcriptional activator CusR YP_002386025.1 598588 R 585034 CDS YP_002386026.1 218553113 7126863 599428..600810 1 NC_011741.1 with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 600810 cusC 7126863 cusC Escherichia coli IAI1 copper/silver efflux system outer membrane protein CusC YP_002386026.1 599428 D 585034 CDS YP_002386027.1 218553114 7126861 600834..601166 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 21125583, 11283292, 11399769, 12813074; Product type f : factor; periplasmic copper-binding protein 601166 cusF 7126861 cusF Escherichia coli IAI1 periplasmic copper-binding protein YP_002386027.1 600834 D 585034 CDS YP_002386028.1 218553115 7126862 601182..602405 1 NC_011741.1 with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB 602405 cusB 7126862 cusB Escherichia coli IAI1 copper/silver efflux system membrane fusion protein CusB YP_002386028.1 601182 D 585034 CDS YP_002386029.1 218553116 7126860 602417..605560 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 21125583, 21178899, 21450803, 11399769, 12813074, 1711024, 7984428; Product type t : transporter; copper/silver efflux system, membrane component 605560 cusA 7126860 cusA Escherichia coli IAI1 copper/silver efflux system, membrane component YP_002386029.1 602417 D 585034 CDS YP_002386030.1 218553117 7126859 605662..607038 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91267923, 94042931, 8626334; Product type t : transporter; phenylalanine transporter 607038 pheP 7126859 pheP Escherichia coli IAI1 phenylalanine transporter YP_002386030.1 605662 D 585034 CDS YP_002386031.1 218553118 7124195 complement(607106..608353) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 608353 ybdG 7124195 ybdG Escherichia coli IAI1 hypothetical protein YP_002386031.1 607106 R 585034 CDS YP_002386032.1 218553119 7124791 complement(608461..609114) 1 NC_011741.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase 609114 nfnB 7124791 nfnB Escherichia coli IAI1 dihydropteridine reductase YP_002386032.1 608461 R 585034 CDS YP_002386033.1 218553120 7127868 complement(609208..609576) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 609576 ybdF 7127868 ybdF Escherichia coli IAI1 hypothetical protein YP_002386033.1 609208 R 585034 CDS YP_002386034.1 218553121 7124790 complement(609641..609889) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 609889 ybdJ 7124790 ybdJ Escherichia coli IAI1 hypothetical protein YP_002386034.1 609641 R 585034 CDS YP_002386035.1 218553122 7124793 complement(609955..611073) 1 NC_011741.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase 611073 ybdK 7124793 ybdK Escherichia coli IAI1 carboxylate-amine ligase YP_002386035.1 609955 R 585034 CDS YP_002386036.1 218553123 7124794 611515..611667 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99291074; Product type f : factor; toxic polypeptide, small 611667 hokE 7124794 hokE Escherichia coli IAI1 toxic polypeptide, small YP_002386036.1 611515 D 585034 CDS YP_002386037.1 218553124 7125290 611919..612170 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10361310; Product type pm : putative membrane component; putative small toxic membrane polypeptide HokE-like protein (partial) 612170 7125290 ECIAI1_0564 Escherichia coli IAI1 putative small toxic membrane polypeptide HokE-like protein (partial) YP_002386037.1 611919 D 585034 CDS YP_002386038.1 218553125 7127039 complement(612292..612921) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89313305, 90132534, 91035252, 8939709, 9214294; Product type e : enzyme; phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex 612921 entD 7127039 entD Escherichia coli IAI1 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex YP_002386038.1 612292 R 585034 CDS YP_002386039.1 218553126 7125071 complement(613087..615327) 1 NC_011741.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA 615327 fepA 7125071 fepA Escherichia coli IAI1 outer membrane receptor FepA YP_002386039.1 613087 R 585034 CDS YP_002386040.1 218553127 7127087 615648..616772 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92291125, 94198561, 2974033; Product type e : enzyme; enterobactin/ferric enterobactin esterase 616772 fes 7127087 fes Escherichia coli IAI1 enterobactin/ferric enterobactin esterase YP_002386040.1 615648 D 585034 CDS YP_002386041.1 218553128 7127093 616775..616993 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 616993 ybdZ 7127093 ybdZ Escherichia coli IAI1 hypothetical protein YP_002386041.1 616775 D 585034 CDS YP_002386042.1 218553129 7124798 616990..620871 1 NC_011741.1 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 620871 entF 7124798 entF Escherichia coli IAI1 enterobactin synthase subunit F YP_002386042.1 616990 D 585034 CDS YP_002386043.1 218553130 7125073 621087..622220 1 NC_011741.1 part of the ferric enterobactin transport system; necessary for enetrobactin uptake; ferric enterobactin transport protein FepE 622220 fepE 7125073 fepE Escherichia coli IAI1 ferric enterobactin transport protein FepE YP_002386043.1 621087 D 585034 CDS YP_002386044.1 218553131 7127091 complement(622217..623032) 1 NC_011741.1 with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein 623032 fepC 7127091 fepC Escherichia coli IAI1 iron-enterobactin transporter ATP-binding protein YP_002386044.1 622217 R 585034 CDS YP_002386045.1 218553132 7127089 complement(623029..624021) 1 NC_011741.1 with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease 624021 fepG 7127089 fepG Escherichia coli IAI1 iron-enterobactin transporter permease YP_002386045.1 623029 R 585034 CDS YP_002386046.1 218553133 7127092 complement(624018..625022) 1 NC_011741.1 with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein 625022 fepD 7127092 fepD Escherichia coli IAI1 iron-enterobactin transporter membrane protein YP_002386046.1 624018 R 585034 CDS YP_002386047.1 218553134 7127090 625133..626383 1 NC_011741.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 626383 ybdA 7127090 ybdA Escherichia coli IAI1 enterobactin exporter EntS YP_002386047.1 625133 D 585034 CDS YP_002386048.1 218553135 7124787 complement(626387..627343) 1 NC_011741.1 with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein 627343 fepB 7124787 fepB Escherichia coli IAI1 iron-enterobactin transporter periplasmic binding protein YP_002386048.1 626387 R 585034 CDS YP_002386049.1 218553136 7127088 627718..628893 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89123153, 90165423, 90241936, 2110093, 2139473; Product type e : enzyme; isochorismate synthase 1 628893 entC 7127088 entC Escherichia coli IAI1 isochorismate synthase 1 YP_002386049.1 627718 D 585034 CDS YP_002386050.1 218553137 7125070 628903..630513 1 NC_011741.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 630513 entE 7125070 entE Escherichia coli IAI1 enterobactin synthase subunit E YP_002386050.1 628903 D 585034 CDS YP_002386051.1 218553138 7125072 630527..631384 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20183918, 90241937, 91035252, 9485415, 97361959, 2521621, 2521622; Product type e : enzyme; isochorismatase 631384 entB 7125072 entB Escherichia coli IAI1 isochorismatase YP_002386051.1 630527 D 585034 CDS YP_002386052.1 218553139 7125069 631384..632130 1 NC_011741.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 632130 entA 7125069 entA Escherichia coli IAI1 2,3-dihydroxybenzoate-2,3-dehydrogenase YP_002386052.1 631384 D 585034 CDS YP_002386053.1 218553140 7125068 632133..632546 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2521621, 2521622, 15808744; Product type pe : putative enzyme; hypothetical protein 632546 ybdB 7125068 ybdB Escherichia coli IAI1 hypothetical protein YP_002386053.1 632133 D 585034 CDS YP_002386054.1 218553141 7124788 632727..634832 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91162636, 2521622; Product type pf : putative factor; carbon starvation protein 634832 cstA 7124788 cstA Escherichia coli IAI1 carbon starvation protein YP_002386054.1 632727 D 585034 CDS YP_002386055.1 218553142 7126856 635014..635211 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 635211 ybdD 7126856 ybdD Escherichia coli IAI1 hypothetical protein YP_002386055.1 635014 D 585034 CDS YP_002386056.1 218553143 7124789 complement(635221..636309) 1 NC_011741.1 member of the iron-containing alcohol dehydrogenase family; unknown function; hypothetical protein 636309 ybdH 7124789 ybdH Escherichia coli IAI1 hypothetical protein YP_002386056.1 635221 R 585034 CDS YP_002386057.1 218553144 7124792 636418..637578 1 NC_011741.1 catalyzes the transfer of an amino moiety; putative aminotransferase 637578 ybdL 7124792 ybdL Escherichia coli IAI1 putative aminotransferase YP_002386057.1 636418 D 585034 CDS YP_002386058.1 218553145 7124795 complement(637579..638208) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator 638208 ibrB 7124795 ibrB Escherichia coli IAI1 immunoglobulin-binding regulator YP_002386058.1 637579 R 585034 CDS YP_002386059.1 218553146 7126042 complement(638181..639401) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator 639401 ibrA 7126042 ibrA Escherichia coli IAI1 immunoglobulin-binding regulator YP_002386059.1 638181 R 585034 CDS YP_002386060.1 218553147 7126041 complement(639548..640450) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator, LysR-type 640450 ybdO 7126041 ybdO Escherichia coli IAI1 putative DNA-binding transcriptional regulator, LysR-type YP_002386060.1 639548 R 585034 CDS YP_002386061.1 218553148 7124796 complement(640659..641405) 1 NC_011741.1 Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase 641405 dsbG 7124796 dsbG Escherichia coli IAI1 disulfide isomerase/thiol-disulfide oxidase YP_002386061.1 640659 R 585034 CDS YP_002386062.1 218553149 7124865 641777..642340 1 NC_011741.1 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase subunit C 642340 ahpC 7124865 ahpC Escherichia coli IAI1 alkyl hydroperoxide reductase subunit C YP_002386062.1 641777 D 585034 CDS YP_002386063.1 218553150 7125736 642469..644034 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89197774, 1592833; Product type e : enzyme; alkyl hydroperoxide reductase, F52a subunit 644034 ahpF 7125736 ahpF Escherichia coli IAI1 alkyl hydroperoxide reductase, F52a subunit YP_002386063.1 642469 D 585034 CDS YP_002386064.1 218553151 7125737 complement(644155..644583) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 12071968; Product type f : factor; universal stress protein UP12 644583 uspG 7125737 uspG Escherichia coli IAI1 universal stress protein UP12 YP_002386064.1 644155 R 585034 CDS YP_002386065.1 218553152 7125553 644804..646042 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8185833; Product type pe : putative enzyme; putative oxidoreductase 646042 ybdR 7125553 ybdR Escherichia coli IAI1 putative oxidoreductase YP_002386065.1 644804 D 585034 CDS YP_002386066.1 218553153 7124797 complement(646273..646683) 1 NC_011741.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator 646683 rnk 7124797 rnk Escherichia coli IAI1 nucleoside diphosphate kinase regulator YP_002386066.1 646273 R 585034 CDS YP_002386067.1 218553154 7125024 complement(646913..647719) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90151658, 90264307, 2253883, 8188249; Product type e : enzyme; ribonuclease I 647719 rna 7125024 rna Escherichia coli IAI1 ribonuclease I YP_002386067.1 646913 R 585034 CDS YP_002386068.1 218553155 7125015 complement(647833..649296) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9696764; Product type t : transporter; citrate:succinate antiporter 649296 citT 7125015 citT Escherichia coli IAI1 citrate:succinate antiporter YP_002386068.1 647833 R 585034 CDS YP_002386069.1 218553156 7126327 complement(649347..650225) 1 NC_011741.1 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase 650225 citG 7126327 citG Escherichia coli IAI1 triphosphoribosyl-dephospho-CoA synthase YP_002386069.1 649347 R 585034 CDS YP_002386070.1 218553157 7126326 complement(650200..650751) 1 NC_011741.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo- citrate lyase 650751 citX 7126326 citX Escherichia coli IAI1 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo- citrate lyase YP_002386070.1 650200 R 585034 CDS YP_002386071.1 218553158 7126328 complement(650755..652287) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase, citrate-ACP transferase alpha subunit 652287 citF 7126328 citF Escherichia coli IAI1 citrate lyase, citrate-ACP transferase alpha subunit YP_002386071.1 650755 R 585034 CDS YP_002386072.1 218553159 7126325 complement(652298..653206) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase, citryl-ACP lyase subunit beta 653206 citE 7126325 citE Escherichia coli IAI1 citrate lyase, citryl-ACP lyase subunit beta YP_002386072.1 652298 R 585034 CDS YP_002386073.1 218553160 7126324 complement(653203..653499) 1 NC_011741.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma 653499 citD 7126324 citD Escherichia coli IAI1 citrate lyase subunit gamma YP_002386073.1 653203 R 585034 CDS YP_002386074.1 218553161 7126323 complement(653514..654572) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase synthetase 654572 citC 7126323 citC Escherichia coli IAI1 citrate lyase synthetase YP_002386074.1 653514 R 585034 CDS YP_002386075.1 218553162 7126322 654952..656610 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11889485, 21885746, 9701802; Product type r : regulator; sensory histidine kinase in two-component regulatory system with citB 656610 citA 7126322 citA Escherichia coli IAI1 sensory histidine kinase in two-component regulatory system with citB YP_002386075.1 654952 D 585034 CDS YP_002386076.1 218553163 7126320 656579..657259 1 NC_011741.1 regulates the expression of citAB in citrate fermentation; two-component response regulator DpiA 657259 dpiA 7126320 dpiA Escherichia coli IAI1 two-component response regulator DpiA YP_002386076.1 656579 D 585034 CDS YP_002386077.1 218553164 7126321 complement(657300..658685) 1 NC_011741.1 responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC 658685 dcuC 7126321 dcuC Escherichia coli IAI1 C4-dicarboxylate transporter DcuC YP_002386077.1 657300 R 585034 CDS YP_002386078.1 218553165 7126929 659274..659834 1 NC_011741.1 catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 659834 pagP 7126929 pagP Escherichia coli IAI1 palmitoyl transferase YP_002386078.1 659274 D 585034 CDS YP_002386079.1 218553166 7126363 660009..660218 1 NC_011741.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 660218 cspE 7126363 cspE Escherichia coli IAI1 cold shock protein CspE YP_002386079.1 660009 D 585034 CDS YP_002386080.1 218553167 7125935 complement(660273..660656) 1 NC_011741.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 660656 crcB 7125935 crcB Escherichia coli IAI1 camphor resistance protein CrcB YP_002386080.1 660273 R 585034 CDS YP_002386081.1 218553168 7126364 660974..661537 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amidase 661537 ybeM 7126364 ybeM Escherichia coli IAI1 putative amidase YP_002386081.1 660974 D 585034 CDS YP_002386082.1 218553169 7124804 661666..661869 1 NC_011741.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein E 661869 tatE 7124804 tatE Escherichia coli IAI1 twin arginine translocase protein E YP_002386082.1 661666 D 585034 CDS YP_002386083.1 218553170 7126218 complement(661970..662935) 1 NC_011741.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 662935 lipA 7126218 lipA Escherichia coli IAI1 lipoyl synthase YP_002386083.1 661970 R 585034 CDS YP_002386084.1 218553171 7126421 complement(663144..664097) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12218038; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 664097 ybeF 7126421 ybeF Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002386084.1 663144 R 585034 CDS YP_002386085.1 218553172 7124802 complement(664356..664997) 1 NC_011741.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 664997 lipB 7124802 lipB Escherichia coli IAI1 lipoate-protein ligase B YP_002386085.1 664356 R 585034 CDS YP_002386086.1 218553173 7126422 complement(665098..665361) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8444795; hypothetical protein 665361 ybeD 7126422 ybeD Escherichia coli IAI1 hypothetical protein YP_002386086.1 665098 R 585034 CDS YP_002386087.1 218553174 7124801 complement(665472..666683) 1 NC_011741.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase fraction A 666683 dacA 7124801 dacA Escherichia coli IAI1 D-alanyl-D-alanine carboxypeptidase fraction A YP_002386087.1 665472 R 585034 CDS YP_002386088.1 218553175 7126908 complement(666822..667910) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88058785, 2644207; Product type lp : lipoprotein; rare lipoprotein A 667910 rlpA 7126908 rlpA Escherichia coli IAI1 rare lipoprotein A YP_002386088.1 666822 R 585034 CDS YP_002386089.1 218553176 7125007 complement(667921..669033) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89123070, 90036736, 91072213, 3316191; Product type cp : cell process; cell wall shape-determining protein 669033 mrdB 7125007 mrdB Escherichia coli IAI1 cell wall shape-determining protein YP_002386089.1 667921 R 585034 CDS YP_002386090.1 218553177 7124473 complement(669036..670937) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86196149, 87030266, 89174517, 2644207; Product type e : enzyme; penicillin-binding protein 2 670937 mrdA 7124473 mrdA Escherichia coli IAI1 penicillin-binding protein 2 YP_002386090.1 669036 R 585034 CDS YP_002386091.1 218553178 7124472 complement(670968..671435) 1 NC_011741.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 671435 ybeA 7124472 ybeA Escherichia coli IAI1 rRNA large subunit methyltransferase YP_002386091.1 670968 R 585034 CDS YP_002386092.1 218553179 7124799 complement(671439..671756) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 671756 ybeB 7124799 ybeB Escherichia coli IAI1 hypothetical protein YP_002386092.1 671439 R 585034 CDS YP_002386093.1 218553180 7124800 complement(672016..672627) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7929373; Product type pe : putative enzyme; putative phosphatase with phosphoglycerate mutase domain 672627 phpB 7124800 phpB Escherichia coli IAI1 putative phosphatase with phosphoglycerate mutase domain YP_002386093.1 672016 R 585034 CDS YP_002386094.1 218553181 7124223 complement(672651..673292) 1 NC_011741.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 673292 nadD 7124223 nadD Escherichia coli IAI1 nicotinic acid mononucleotide adenylyltransferase YP_002386094.1 672651 R 585034 CDS YP_002386095.1 218553182 7124514 complement(673294..674325) 1 NC_011741.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 674325 holA 7124514 holA Escherichia coli IAI1 DNA polymerase III subunit delta YP_002386095.1 673294 R 585034 CDS YP_002386096.1 218553183 7125291 complement(674325..674906) 1 NC_011741.1 rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB 674906 rlpB 7125291 rlpB Escherichia coli IAI1 LPS-assembly lipoprotein RlpB YP_002386096.1 674325 R 585034 CDS YP_002386097.1 218553184 7125008 complement(674921..677503) 1 NC_011741.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 677503 leuS 7125008 leuS Escherichia coli IAI1 leucyl-tRNA synthetase YP_002386097.1 674921 R 585034 CDS YP_002386098.1 218553185 7126413 677738..678220 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11373298, 12105207, 3320963, 7567469; hypothetical protein 678220 ybeL 7126413 ybeL Escherichia coli IAI1 hypothetical protein YP_002386098.1 677738 D 585034 CDS YP_002386099.1 218553186 7124803 complement(678290..679267) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 679267 ybeQ 7124803 ybeQ Escherichia coli IAI1 hypothetical protein YP_002386099.1 678290 R 585034 CDS YP_002386100.1 218553187 7124805 679431..680138 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 680138 ybeR 7124805 ybeR Escherichia coli IAI1 hypothetical protein YP_002386100.1 679431 D 585034 CDS YP_002386101.1 218553188 7124806 680135..681562 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12183460, 10574456; Product type pf : putative factor; putative DnaJ-class chaperone 681562 djlB 7124806 djlB Escherichia coli IAI1 putative DnaJ-class chaperone YP_002386101.1 680135 D 585034 CDS YP_002386102.1 218553189 7124594 complement(681572..682126) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 682126 ybeT 7124594 ybeT Escherichia coli IAI1 hypothetical protein YP_002386102.1 681572 R 585034 CDS YP_002386103.1 218553190 7124807 682227..682934 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 682934 ybeU 7124807 ybeU Escherichia coli IAI1 hypothetical protein YP_002386103.1 682227 D 585034 CDS YP_002386104.1 218553191 7124808 682931..684382 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12183460, 12054669; Product type f : factor; Hsc56 co-chaperone of HscC 684382 djlC 7124808 djlC Escherichia coli IAI1 Hsc56 co-chaperone of HscC YP_002386104.1 682931 D 585034 CDS YP_002386105.1 218553192 7124595 complement(684442..686112) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12183460, 14734171, 22055095, 9735342; Product type f : factor; Hsp70 family chaperone Hsc62, binds to RpoD and inhibits transcription 686112 hscC 7124595 hscC Escherichia coli IAI1 Hsp70 family chaperone Hsc62, binds to RpoD and inhibits transcription YP_002386105.1 684442 R 585034 CDS YP_002386106.1 218553193 7125311 complement(686196..687131) 1 NC_011741.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 687131 rihA 7125311 rihA Escherichia coli IAI1 ribonucleoside hydrolase 1 YP_002386106.1 686196 R 585034 CDS YP_002386107.1 218553194 7124998 complement(687249..687974) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate ABC transporter ATP-binding protein 687974 gltL 7124998 gltL Escherichia coli IAI1 glutamate and aspartate ABC transporter ATP-binding protein YP_002386107.1 687249 R 585034 CDS YP_002386108.1 218553195 7128352 complement(687974..688648) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate ABC transporter membrane protein 688648 gltK 7128352 gltK Escherichia coli IAI1 glutamate and aspartate ABC transporter membrane protein YP_002386108.1 687974 R 585034 CDS YP_002386109.1 218553196 7128351 complement(688648..689388) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate ABC transporter membrane protein 689388 gltJ 7128351 gltJ Escherichia coli IAI1 glutamate and aspartate ABC transporter membrane protein YP_002386109.1 688648 R 585034 CDS YP_002386110.1 218553197 7125489 complement(689558..690466) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1091636, 1091635, 10493123, 8740179, 10972807; Product type t : transporter; glutamate and aspartate transporter subunit 690466 gltI 7125489 gltI Escherichia coli IAI1 glutamate and aspartate transporter subunit YP_002386110.1 689558 R 585034 CDS YP_002386111.1 218553198 7128349 690921..692798 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 692798 7128349 ECIAI1_0640 Escherichia coli IAI1 hypothetical protein YP_002386111.1 690921 D 585034 CDS YP_002386112.1 218553199 7127040 complement(692876..694414) 1 NC_011741.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 694414 lnt 7127040 lnt Escherichia coli IAI1 apolipoprotein N-acyltransferase YP_002386112.1 692876 R 585034 CDS YP_002386113.1 218553200 7126432 complement(694439..695317) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1779764; Product type pt : putative transporter; hypothetical protein 695317 ybeX 7126432 ybeX Escherichia coli IAI1 hypothetical protein YP_002386113.1 694439 R 585034 CDS YP_002386114.1 218553201 7124809 complement(695407..695874) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16511207; Product type pe : putative enzyme; putative metalloprotease 695874 ybeY 7124809 ybeY Escherichia coli IAI1 putative metalloprotease YP_002386114.1 695407 R 585034 CDS YP_002386115.1 218553202 7124810 complement(695871..696950) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12762842; Product type pe : putative enzyme; hypothetical protein 696950 ybeZ 7124810 ybeZ Escherichia coli IAI1 hypothetical protein YP_002386115.1 695871 R 585034 CDS YP_002386116.1 218553203 7124811 complement(697064..698488) 1 NC_011741.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 698488 miaB 7124811 miaB Escherichia coli IAI1 (dimethylallyl)adenosine tRNA methylthiotransferase YP_002386116.1 697064 R 585034 CDS YP_002386117.1 218553204 7124271 698634..699809 1 NC_011741.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 699809 ubiF 7124271 ubiF Escherichia coli IAI1 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase YP_002386117.1 698634 D 585034 CDS YP_002386119.1 218553206 7128061 complement(700628..700810) 1 NC_011741.1 hypothetical protein 700810 7128061 ECIAI1_0650 Escherichia coli IAI1 hypothetical protein YP_002386119.1 700628 R 585034 CDS YP_002386120.1 218553207 7127042 complement(701047..702711) 1 NC_011741.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B 702711 asnB 7127042 asnB Escherichia coli IAI1 asparagine synthetase B YP_002386120.1 701047 R 585034 CDS YP_002386121.1 218553208 7126262 complement(702968..703720) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16430214, 89343637; Product type e : enzyme; UMP phosphatase 703720 nagD 7126262 nagD Escherichia coli IAI1 UMP phosphatase YP_002386121.1 702968 R 585034 CDS YP_002386122.1 218553209 7124520 complement(703768..704988) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15066032, 90136533, 91171292, 92114782, 92356048, 2190615, 2668691, 7545108; Product type r : regulator; DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine 704988 nagC 7124520 nagC Escherichia coli IAI1 DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine YP_002386122.1 703768 R 585034 CDS YP_002386123.1 218553210 7124519 complement(704997..706145) 1 NC_011741.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 706145 nagA 7124519 nagA Escherichia coli IAI1 N-acetylglucosamine-6-phosphate deacetylase YP_002386123.1 704997 R 585034 CDS YP_002386124.1 218553211 7124517 complement(706205..707005) 1 NC_011741.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 707005 nagB 7124517 nagB Escherichia coli IAI1 glucosamine-6-phosphate deaminase YP_002386124.1 706205 R 585034 CDS YP_002386125.1 218553212 7124518 707338..709284 1 NC_011741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunits IIABC 709284 nagE 7124518 nagE Escherichia coli IAI1 PTS system N-acetyl glucosamine specific transporter subunits IIABC YP_002386125.1 707338 D 585034 CDS YP_002386126.1 218553213 7124521 709487..711151 1 NC_011741.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 711151 glnS 7124521 glnS Escherichia coli IAI1 glutaminyl-tRNA synthetase YP_002386126.1 709487 D 585034 CDS YP_002386127.1 218553214 7128331 711597..713003 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2118530, 9636669; Product type pt : putative transporter; putative outer membrane porin 713003 ybfM 7128331 ybfM Escherichia coli IAI1 putative outer membrane porin YP_002386127.1 711597 D 585034 CDS YP_002386128.1 218553215 7124816 713053..713379 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 713379 ybfN 7124816 ybfN Escherichia coli IAI1 hypothetical protein YP_002386128.1 713053 D 585034 CDS YP_002386129.1 218553216 7124817 complement(713463..713909) 1 NC_011741.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator 713909 fur 7124817 fur Escherichia coli IAI1 ferric uptake regulator YP_002386129.1 713463 R 585034 CDS YP_002386130.1 218553217 7128255 713954..714208 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 714208 7128255 ECIAI1_0662 Escherichia coli IAI1 hypothetical protein YP_002386130.1 713954 D 585034 CDS YP_002386131.1 218553218 7127043 complement(714198..714728) 1 NC_011741.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA 714728 fldA 7127043 fldA Escherichia coli IAI1 flavodoxin FldA YP_002386131.1 714198 R 585034 CDS YP_002386132.1 218553219 7127209 complement(714868..715161) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20223640, 12427949; Product type cp : cell process; LexA regulated protein 715161 ybfE 7127209 ybfE Escherichia coli IAI1 LexA regulated protein YP_002386132.1 714868 R 585034 CDS YP_002386133.1 218553220 7124814 complement(715301..716065) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme; hypothetical protein 716065 ybfF 7124814 ybfF Escherichia coli IAI1 hypothetical protein YP_002386133.1 715301 R 585034 CDS YP_002386134.1 218553221 7124815 716250..716795 1 NC_011741.1 negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 716795 seqA 7124815 seqA Escherichia coli IAI1 replication initiation regulator SeqA YP_002386134.1 716250 D 585034 CDS YP_002386135.1 218553222 7127907 716821..718461 1 NC_011741.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 718461 pgm 7127907 pgm Escherichia coli IAI1 phosphoglucomutase YP_002386135.1 716821 D 585034 CDS YP_002386136.1 218553223 7124188 complement(718517..719836) 1 NC_011741.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter 719836 potE 7124188 potE Escherichia coli IAI1 putrescine transporter YP_002386136.1 718517 R 585034 CDS YP_002386137.1 218553224 7126117 complement(719833..722031) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92041955; Product type e : enzyme; ornithine decarboxylase 722031 speF 7126117 speF Escherichia coli IAI1 ornithine decarboxylase YP_002386137.1 719833 R 585034 CDS YP_002386138.1 218553225 7127959 complement(722721..723398) 1 NC_011741.1 response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; DNA-binding transcriptional activator KdpE 723398 kdpE 7127959 kdpE Escherichia coli IAI1 DNA-binding transcriptional activator KdpE YP_002386138.1 722721 R 585034 CDS YP_002386139.1 218553226 7126377 complement(723395..726079) 1 NC_011741.1 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; sensor protein KdpD 726079 kdpD 7126377 kdpD Escherichia coli IAI1 sensor protein KdpD YP_002386139.1 723395 R 585034 CDS YP_002386140.1 218553227 7126376 complement(726072..726644) 1 NC_011741.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 726644 kdpC 7126376 kdpC Escherichia coli IAI1 potassium-transporting ATPase subunit C YP_002386140.1 726072 R 585034 CDS YP_002386141.1 218553228 7126375 complement(726653..728701) 1 NC_011741.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 728701 kdpB 7126375 kdpB Escherichia coli IAI1 potassium-transporting ATPase subunit B YP_002386141.1 726653 R 585034 CDS YP_002386142.1 218553229 7126374 complement(728724..730397) 1 NC_011741.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 730397 kdpA 7126374 kdpA Escherichia coli IAI1 potassium-transporting ATPase subunit A YP_002386142.1 728724 R 585034 CDS YP_002386143.1 218553230 7126373 730799..731005 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 731005 ybfA 7126373 ybfA Escherichia coli IAI1 hypothetical protein YP_002386143.1 730799 D 585034 CDS YP_002386144.1 218553231 7124812 731248..735441 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 98361897, 2403547, 2644231, 7934896, 8387990; Product type h : extrachromosomal origin; rhsC element core protein RshC 735441 rhsC 7124812 rhsC Escherichia coli IAI1 rhsC element core protein RshC YP_002386144.1 731248 D 585034 CDS YP_002386145.1 218553232 7124985 735885..737318 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 737318 ybfO 7124985 ybfO Escherichia coli IAI1 hypothetical protein YP_002386145.1 735885 D 585034 CDS YP_002386146.1 218553233 7124818 737315..737884 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 737884 ybfC 7124818 ybfC Escherichia coli IAI1 hypothetical protein YP_002386146.1 737315 D 585034 CDS YP_002386147.1 218553234 7127145 739399..739908 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6325460, 8387990; hypothetical protein 739908 ybgA 7127145 ybgA Escherichia coli IAI1 hypothetical protein YP_002386147.1 739399 D 585034 CDS YP_002386148.1 218553235 7124819 739905..741323 1 NC_011741.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 741323 phr 7124819 phr Escherichia coli IAI1 deoxyribodipyrimidine photolyase YP_002386148.1 739905 D 585034 CDS YP_002386149.1 218553236 7124224 complement(741365..742846) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15175316; Product type pt : putative transporter; putative transporter 742846 ybgH 7124224 ybgH Escherichia coli IAI1 putative transporter YP_002386149.1 741365 R 585034 CDS YP_002386150.1 218553237 7124823 743117..743860 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14519207; putative hydrolase-oxidase 743860 ybgI 7124823 ybgI Escherichia coli IAI1 putative hydrolase-oxidase YP_002386150.1 743117 D 585034 CDS YP_002386151.1 218553238 7124824 743883..744539 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase subunit 744539 ybgJ 7124824 ybgJ Escherichia coli IAI1 putative hydrolase subunit YP_002386151.1 743883 D 585034 CDS YP_002386152.1 218553239 7124825 744533..745465 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase subunit 745465 ybgK 7124825 ybgK Escherichia coli IAI1 putative hydrolase subunit YP_002386152.1 744533 D 585034 CDS YP_002386153.1 218553240 7124826 745455..746189 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1729609; Product type pe : putative enzyme; LamB/YcsF family protein 746189 ybgL 7124826 ybgL Escherichia coli IAI1 LamB/YcsF family protein YP_002386153.1 745455 D 585034 CDS YP_002386154.1 218553241 7124827 746225..747016 1 NC_011741.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 747016 nei 7124827 nei Escherichia coli IAI1 endonuclease VIII YP_002386154.1 746225 D 585034 CDS YP_002386155.1 218553242 7127865 complement(747013..748059) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8002588; Product type ph : phenotype; hypothetical protein 748059 abrB 7127865 abrB Escherichia coli IAI1 hypothetical protein YP_002386155.1 747013 R 585034 CDS YP_002386156.1 218553243 7125689 complement(748211..749272) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 749272 ybgO 7125689 ybgO Escherichia coli IAI1 hypothetical protein YP_002386156.1 748211 R 585034 CDS YP_002386157.1 218553244 7124828 complement(749269..750024) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10049807; Product type pf : putative factor; putative exported chaperone, PapD family 750024 ybgP 7124828 ybgP Escherichia coli IAI1 putative exported chaperone, PapD family YP_002386157.1 749269 R 585034 CDS YP_002386158.1 218553245 7124829 complement(750015..752516) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 752516 ybgQ 7124829 ybgQ Escherichia coli IAI1 hypothetical protein YP_002386158.1 750015 R 585034 CDS YP_002386159.1 218553246 7124830 complement(752525..753091) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative fimbrial-like adhesin protein 753091 7124830 ECIAI1_0693 Escherichia coli IAI1 putative fimbrial-like adhesin protein YP_002386159.1 752525 R 585034 CDS YP_002386160.1 218553247 7127044 complement(753482..754765) 1 NC_011741.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 754765 gltA 7127044 gltA Escherichia coli IAI1 type II citrate synthase YP_002386160.1 753482 R 585034 CDS YP_002386161.1 218553248 7128346 755474..755863 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6237244, 89076355, 89123360, 9521736, 99414342, 11259408, 3309132, 6383359, 9822661; Product type m : membrane component; succinate dehydrogenase cytochrome b556 large membrane subunit 755863 sdhC 7128346 sdhC Escherichia coli IAI1 succinate dehydrogenase cytochrome b556 large membrane subunit YP_002386161.1 755474 D 585034 CDS YP_002386162.1 218553249 7124688 755857..756204 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82124790, 89076355, 9521736, 99414342, 6383359; Product type m : membrane component; succinate dehydrogenase cytochrome b556 small membrane subunit 756204 sdhD 7124688 sdhD Escherichia coli IAI1 succinate dehydrogenase cytochrome b556 small membrane subunit YP_002386162.1 755857 D 585034 CDS YP_002386163.1 218553250 7124689 756204..757970 1 NC_011741.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 757970 sdhA 7124689 sdhA Escherichia coli IAI1 succinate dehydrogenase flavoprotein subunit YP_002386163.1 756204 D 585034 CDS YP_002386164.1 218553251 7124686 757986..758702 1 NC_011741.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 758702 sdhB 7124686 sdhB Escherichia coli IAI1 succinate dehydrogenase iron-sulfur subunit YP_002386164.1 757986 D 585034 CDS YP_002386165.1 218553252 7124687 758903..761704 1 NC_011741.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 761704 sucA 7124687 sucA Escherichia coli IAI1 2-oxoglutarate dehydrogenase E1 component YP_002386165.1 758903 D 585034 CDS YP_002386166.1 218553253 7126188 761719..762936 1 NC_011741.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 762936 sucB 7126188 sucB Escherichia coli IAI1 dihydrolipoamide succinyltransferase YP_002386166.1 761719 D 585034 CDS YP_002386167.1 218553254 7126189 763030..764196 1 NC_011741.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 764196 sucC 7126189 sucC Escherichia coli IAI1 succinyl-CoA synthetase subunit beta YP_002386167.1 763030 D 585034 CDS YP_002386168.1 218553255 7126190 764196..765065 1 NC_011741.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 765065 sucD 7126190 sucD Escherichia coli IAI1 succinyl-CoA synthetase subunit alpha YP_002386168.1 764196 D 585034 CDS YP_002386169.1 218553256 7124650 complement(765169..765891) 1 NC_011741.1 regulates the succiny-lCoA synthetase operon; DNA-binding transcriptional repressor MngR 765891 mngR 7124650 mngR Escherichia coli IAI1 DNA-binding transcriptional repressor MngR YP_002386169.1 765169 R 585034 CDS YP_002386170.1 218553257 7124287 766000..767976 1 NC_011741.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC 767976 mngA 7124287 mngA Escherichia coli IAI1 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC YP_002386170.1 766000 D 585034 CDS YP_002386171.1 218553258 7124285 767994..770627 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14645248, 9063979; Product type e : enzyme; alpha-mannosidase 770627 mngB 7124285 mngB Escherichia coli IAI1 alpha-mannosidase YP_002386171.1 767994 D 585034 CDS YP_002386172.1 218553259 7124286 770652..770879 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 770879 7124286 ECIAI1_0706 Escherichia coli IAI1 hypothetical protein YP_002386172.1 770652 D 585034 CDS YP_002386173.1 218553260 7126930 771474..773042 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87299685, 89255232, 91035243, 1689724, 1724280, 2843510, 3138232; Product type c : carrier; cytochrome d terminal oxidase subunit I 773042 cydA 7126930 cydA Escherichia coli IAI1 cytochrome d terminal oxidase subunit I YP_002386173.1 771474 D 585034 CDS YP_002386174.1 218553261 7126874 773058..774197 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87299685, 89255232, 91035243, 2843510, 3138232; Product type c : carrier; cytochrome d terminal oxidase subunit II 774197 cydB 7126874 cydB Escherichia coli IAI1 cytochrome d terminal oxidase subunit II YP_002386174.1 773058 D 585034 CDS YP_002386175.1 218553262 7126875 774325..774618 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 774618 ybgE 7126875 ybgE Escherichia coli IAI1 hypothetical protein YP_002386175.1 774325 D 585034 CDS YP_002386176.1 218553263 7124821 774768..775172 1 NC_011741.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase YbgC 775172 ybgC 7124821 ybgC Escherichia coli IAI1 acyl-CoA thioester hydrolase YbgC YP_002386176.1 774768 D 585034 CDS YP_002386177.1 218553264 7124820 775169..775861 1 NC_011741.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 775861 tolQ 7124820 tolQ Escherichia coli IAI1 colicin uptake protein TolQ YP_002386177.1 775169 D 585034 CDS YP_002386178.1 218553265 7127461 775865..776293 1 NC_011741.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 776293 tolR 7127461 tolR Escherichia coli IAI1 colicin uptake protein TolR YP_002386178.1 775865 D 585034 CDS YP_002386179.1 218553266 7127462 776358..777623 1 NC_011741.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 777623 tolA 7127462 tolA Escherichia coli IAI1 cell envelope integrity inner membrane protein TolA YP_002386179.1 776358 D 585034 CDS YP_002386180.1 218553267 7127458 777756..779048 1 NC_011741.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 779048 tolB 7127458 tolB Escherichia coli IAI1 translocation protein TolB YP_002386180.1 777756 D 585034 CDS YP_002386181.1 218553268 7127459 779083..779604 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11790745, 87133578, 92244043, 99403391, 11173492, 2687247; Product type lp : lipoprotein; peptidoglycan-associated outer membrane lipoprotein 779604 pal 7127459 pal Escherichia coli IAI1 peptidoglycan-associated outer membrane lipoprotein YP_002386181.1 779083 D 585034 CDS YP_002386182.1 218553269 7124149 779614..780405 1 NC_011741.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 780405 ybgF 7124149 ybgF Escherichia coli IAI1 tol-pal system protein YbgF YP_002386182.1 779614 D 585034 CDS YP_002386183.1 218553270 7127988 781974..783017 1 NC_011741.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 783017 nadA 7127988 nadA Escherichia coli IAI1 quinolinate synthetase YP_002386183.1 781974 D 585034 CDS YP_002386184.1 218553271 7124511 783055..783774 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 219824, 90330519; Product type t : transporter; nicotinamide mononucleotide transporter 783774 pnuC 7124511 pnuC Escherichia coli IAI1 nicotinamide mononucleotide transporter YP_002386184.1 783055 D 585034 CDS YP_002386185.1 218553272 7126110 complement(783771..784712) 1 NC_011741.1 involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB 784712 zitB 7126110 zitB Escherichia coli IAI1 zinc transporter ZitB YP_002386185.1 783771 R 585034 CDS YP_002386186.1 218553273 7128125 complement(784826..785206) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 785206 ybgS 7128125 ybgS Escherichia coli IAI1 hypothetical protein YP_002386186.1 784826 R 585034 CDS YP_002386187.1 218553274 7124831 785522..786574 1 NC_011741.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 786574 aroG 7124831 aroG Escherichia coli IAI1 phospho-2-dehydro-3-deoxyheptonate aldolase YP_002386187.1 785522 D 585034 CDS YP_002386188.1 218553275 7125808 complement(786733..787485) 1 NC_011741.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 787485 gpmA 7125808 gpmA Escherichia coli IAI1 phosphoglyceromutase YP_002386188.1 786733 R 585034 CDS YP_002386189.1 218553276 7128458 complement(787690..788730) 1 NC_011741.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase 788730 galM 7128458 galM Escherichia coli IAI1 aldose 1-epimerase YP_002386189.1 787690 R 585034 CDS YP_002386190.1 218553277 7128271 complement(788724..789872) 1 NC_011741.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 789872 galK 7128271 galK Escherichia coli IAI1 galactokinase YP_002386190.1 788724 R 585034 CDS YP_002386191.1 218553278 7128270 complement(789876..790922) 1 NC_011741.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 790922 galT 7128270 galT Escherichia coli IAI1 galactose-1-phosphate uridylyltransferase YP_002386191.1 789876 R 585034 CDS YP_002386192.1 218553279 7128275 complement(790932..791948) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89274199, 92253563, 92338916, 3022232, 6301942, 8564363, 8611559, 8931134, 9174344, 9271499, 9708982; Product type e : enzyme; UDP-galactose-4-epimerase 791948 galE 7128275 galE Escherichia coli IAI1 UDP-galactose-4-epimerase YP_002386192.1 790932 R 585034 CDS YP_002386193.1 218553280 7128268 complement(792210..793682) 1 NC_011741.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum; putative molybdenum transport ATP-binding protein ModF 793682 modF 7128268 modF Escherichia coli IAI1 putative molybdenum transport ATP-binding protein ModF YP_002386193.1 792210 R 585034 CDS YP_002386194.1 218553281 7124301 complement(793750..794538) 1 NC_011741.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE 794538 modE 7124301 modE Escherichia coli IAI1 DNA-binding transcriptional regulator ModE YP_002386194.1 793750 R 585034 CDS YP_002386195.1 218553282 7124300 794667..794816 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 794816 ybhT 7124300 ybhT Escherichia coli IAI1 hypothetical protein YP_002386195.1 794667 D 585034 CDS YP_002386196.1 218553283 7124850 794983..795756 1 NC_011741.1 with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein 795756 modA 7124850 modA Escherichia coli IAI1 molybdate transporter periplasmic protein YP_002386196.1 794983 D 585034 CDS YP_002386197.1 218553284 7124297 795756..796445 1 NC_011741.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 796445 modB 7124297 modB Escherichia coli IAI1 molybdate ABC transporter permease YP_002386197.1 795756 D 585034 CDS YP_002386198.1 218553285 7124298 796448..797506 1 NC_011741.1 Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 797506 modC 7124298 modC Escherichia coli IAI1 molybdate transporter ATP-binding protein YP_002386198.1 796448 D 585034 CDS YP_002386199.1 218553286 7124299 complement(797507..798325) 1 NC_011741.1 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase 798325 ybhA 7124299 ybhA Escherichia coli IAI1 phosphotransferase YP_002386199.1 797507 R 585034 CDS YP_002386200.1 218553287 7124832 798480..799475 1 NC_011741.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 799475 pgl 7124832 pgl Escherichia coli IAI1 6-phosphogluconolactonase YP_002386200.1 798480 D 585034 CDS YP_002386201.1 218553288 7124187 complement(799516..800532) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 800532 ybhD 7124187 ybhD Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002386201.1 799516 R 585034 CDS YP_002386202.1 218553289 7124835 800387..800536 1 NC_011741.1 hypothetical protein 800536 7124835 ECIAI1_0737 Escherichia coli IAI1 hypothetical protein YP_002386202.1 800387 D 585034 CDS YP_002386203.1 218553290 7126931 800653..801705 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 801705 ybhH 7126931 ybhH Escherichia coli IAI1 hypothetical protein YP_002386203.1 800653 D 585034 CDS YP_002386204.1 218553291 7124838 801781..803214 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative anion transporter 803214 ybhI 7124838 ybhI Escherichia coli IAI1 putative anion transporter YP_002386204.1 801781 D 585034 CDS YP_002386205.1 218553292 7124839 803115..803285 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 803285 7124839 ECIAI1_0740 Escherichia coli IAI1 hypothetical protein YP_002386205.1 803115 D 585034 CDS YP_002386206.1 218553293 7126932 803397..805658 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11782506; Product type pe : putative enzyme; hypothetical protein 805658 ybhJ 7126932 ybhJ Escherichia coli IAI1 hypothetical protein YP_002386206.1 803397 D 585034 CDS YP_002386207.1 218553294 7124840 complement(805892..807175) 1 NC_011741.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family; putative pectinesterase 807175 ybhC 7124840 ybhC Escherichia coli IAI1 putative pectinesterase YP_002386207.1 805892 R 585034 CDS YP_002386208.1 218553295 7124834 complement(807310..808380) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6446713; Product type h : extrachromosomal origin; Integrase from phage 808380 int 7124834 int Escherichia coli IAI1 Integrase from phage YP_002386208.1 807310 R 585034 CDS YP_002386209.1 218553296 7126071 complement(808675..808842) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 808842 7126071 ECIAI1_0745 Escherichia coli IAI1 hypothetical protein YP_002386209.1 808675 R 585034 CDS YP_002386210.1 218553297 7126933 complement(808871..809704) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1718819, 7737514; Product type pe : putative enzyme; transposase, ORF B, IS3 family, IS407 group 809704 7126933 ECIAI1_0746 Escherichia coli IAI1 transposase, ORF B, IS3 family, IS407 group YP_002386210.1 808871 R 585034 CDS YP_002386211.1 218553298 7126934 complement(809728..809991) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15126494, 7737514; Product type pe : putative enzyme; transposase, ORF A, IS3 family, IS407 group 809991 7126934 ECIAI1_0747 Escherichia coli IAI1 transposase, ORF A, IS3 family, IS407 group YP_002386211.1 809728 R 585034 CDS YP_002386212.1 218553299 7126935 complement(810227..810379) 1 NC_011741.1 hypothetical protein 810379 7126935 ECIAI1_0748 Escherichia coli IAI1 hypothetical protein YP_002386212.1 810227 R 585034 CDS YP_002386213.1 218553300 7126936 complement(810357..810641) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 810641 7126936 ECIAI1_0749 Escherichia coli IAI1 hypothetical protein YP_002386213.1 810357 R 585034 CDS YP_002386214.1 218553301 7126937 complement(810726..811301) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative DnaJ-class molecular chaperone with C-terminal Zn finger domain 811301 7126937 ECIAI1_0750 Escherichia coli IAI1 putative DnaJ-class molecular chaperone with C-terminal Zn finger domain YP_002386214.1 810726 R 585034 CDS YP_002386215.1 218553302 7126938 complement(811312..812109) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 812109 7126938 ECIAI1_0751 Escherichia coli IAI1 hypothetical protein YP_002386215.1 811312 R 585034 CDS YP_002386216.1 218553303 7126939 complement(812069..812476) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 812476 7126939 ECIAI1_0752 Escherichia coli IAI1 hypothetical protein YP_002386216.1 812069 R 585034 CDS YP_002386217.1 218553304 7126940 complement(812473..812694) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 812694 7126940 ECIAI1_0753 Escherichia coli IAI1 hypothetical protein YP_002386217.1 812473 R 585034 CDS YP_002386218.1 218553305 7126941 complement(812793..813074) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 813074 7126941 ECIAI1_0754 Escherichia coli IAI1 hypothetical protein YP_002386218.1 812793 R 585034 CDS YP_002386219.1 218553306 7126942 complement(813428..814108) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; exonuclease from phage origin 814108 7126942 ECIAI1_0756 Escherichia coli IAI1 exonuclease from phage origin YP_002386219.1 813428 R 585034 CDS YP_002386220.1 218553307 7126943 complement(814105..814890) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 6458018, 6221115; Product type h : extrachromosomal origin; Recombination protein bet from phage origin 814890 7126943 ECIAI1_0757 Escherichia coli IAI1 Recombination protein bet from phage origin YP_002386220.1 814105 R 585034 CDS YP_002386221.1 218553308 7126944 complement(814896..815192) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative host-nuclease inhibitor protein Gam of bacteriophage 815192 7126944 ECIAI1_0758 Escherichia coli IAI1 putative host-nuclease inhibitor protein Gam of bacteriophage YP_002386221.1 814896 R 585034 CDS YP_002386222.1 218553309 7126945 complement(815269..815679) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative prophage Kil protein 815679 7126945 ECIAI1_0759 Escherichia coli IAI1 putative prophage Kil protein YP_002386222.1 815269 R 585034 CDS YP_002386223.1 218553310 7126946 complement(815954..816466) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 816466 7126946 ECIAI1_0760 Escherichia coli IAI1 hypothetical protein YP_002386223.1 815954 R 585034 CDS YP_002386224.1 218553311 7126947 complement(816463..817602) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase m, neutral zinc metallopeptidases, zinc-binding site; protein 817602 7126947 ECIAI1_0761 Escherichia coli IAI1 putative peptidase m, neutral zinc metallopeptidases, zinc-binding site; protein YP_002386224.1 816463 R 585034 CDS YP_002386225.1 218553312 7126948 complement(817732..818460) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Regulatory protein CI from bacteriophage origin 818460 7126948 ECIAI1_0762 Escherichia coli IAI1 Regulatory protein CI from bacteriophage origin YP_002386225.1 817732 R 585034 CDS YP_002386226.1 218553313 7126949 818529..818762 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; represror Cro 818762 cro 7126949 cro Escherichia coli IAI1 represror Cro YP_002386226.1 818529 D 585034 CDS YP_002386227.1 218553314 7125913 818787..819332 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 612476; Product type h : extrachromosomal origin; Regulatory protein CII from bacteriophage origin 819332 7125913 ECIAI1_0764 Escherichia coli IAI1 Regulatory protein CII from bacteriophage origin YP_002386227.1 818787 D 585034 CDS YP_002386228.1 218553315 7126950 819329..820348 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2995831; Product type h : extrachromosomal origin; Replication protein O frm phage origin 820348 7126950 ECIAI1_0765 Escherichia coli IAI1 Replication protein O frm phage origin YP_002386228.1 819329 D 585034 CDS YP_002386229.1 218553316 7126951 820345..821046 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative replication protein P of bacteriophage 821046 7126951 ECIAI1_0766 Escherichia coli IAI1 putative replication protein P of bacteriophage YP_002386229.1 820345 D 585034 CDS YP_002386230.1 218553317 7126952 821625..822377 1 NC_011741.1 hypothetical protein 822377 7126952 ECIAI1_0767 Escherichia coli IAI1 hypothetical protein YP_002386230.1 821625 D 585034 CDS YP_002386231.1 218553318 7126953 822389..822463 1 NC_011741.1 putative inner membrane protein (fragment) 822463 7126953 ECIAI1_0768 Escherichia coli IAI1 putative inner membrane protein (fragment) YP_002386231.1 822389 D 585034 CDS YP_002386232.1 218553319 7126954 822634..823116 1 NC_011741.1 hypothetical protein 823116 7126954 ECIAI1_0769 Escherichia coli IAI1 hypothetical protein YP_002386232.1 822634 D 585034 CDS YP_002386233.1 218553320 7126955 823306..823761 1 NC_011741.1 DLP12 prophage; hypothetical protein 823761 ybcN 7126955 ybcN Escherichia coli IAI1 hypothetical protein YP_002386233.1 823306 D 585034 CDS YP_002386234.1 218553321 7124783 823761..823931 1 NC_011741.1 DLP12 prophage; conserved protein similar to phage 82 and lambda proteins; prophage protein NinE 823931 ninE 7124783 ninE Escherichia coli IAI1 prophage protein NinE YP_002386234.1 823761 D 585034 CDS YP_002386235.1 218553322 7127883 823924..824214 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 824214 ybcO 7127883 ybcO Escherichia coli IAI1 hypothetical protein YP_002386235.1 823924 D 585034 CDS YP_002386236.1 218553323 7124784 824211..824573 1 NC_011741.1 DLP12 prophage; Holliday junction resolvase; endodeoxyribonuclease RUS 824573 rusA 7124784 rusA Escherichia coli IAI1 endodeoxyribonuclease RUS YP_002386236.1 824211 D 585034 CDS YP_002386237.1 218553324 7124635 824796..825179 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8648624, 9278503; Product type pf : putative factor; putative antitermination protein Q-like protein; DLP12 prophage 825179 ybcQ 7124635 ybcQ Escherichia coli IAI1 putative antitermination protein Q-like protein; DLP12 prophage YP_002386237.1 824796 D 585034 CDS YP_002386238.1 218553325 7124785 complement(825369..826466) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 3017988, 8057841; Product type m : membrane component; outer membrane porin; DLP12 prophage 826466 nmpC 7124785 nmpC Escherichia coli IAI1 outer membrane porin; DLP12 prophage YP_002386238.1 825369 R 585034 CDS YP_002386239.1 218553326 7127893 827055..827270 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019562; Product type pe : putative enzyme; putative phage lysis protein S; DLP12 prophage 827270 essD 7127893 essD Escherichia coli IAI1 putative phage lysis protein S; DLP12 prophage YP_002386239.1 827055 D 585034 CDS YP_002386240.1 218553327 7125090 827270..827767 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3017988; Product type pe : putative enzyme; putative lysozyme; DLP12 prophage 827767 ybcS 7125090 ybcS Escherichia coli IAI1 putative lysozyme; DLP12 prophage YP_002386240.1 827270 D 585034 CDS YP_002386241.1 218553328 7124786 827764..828225 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019562; Product type pe : putative enzyme; putative murein endopeptidase; DLP12 prophage 828225 rzpD 7124786 rzpD Escherichia coli IAI1 putative murein endopeptidase; DLP12 prophage YP_002386241.1 827764 D 585034 CDS YP_002386242.1 218553329 7124667 complement(828257..828598) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 95173101; Product type pm : putative membrane component; putative lipoprotein; DLP12 prophage 828598 borD 7124667 borD Escherichia coli IAI1 putative lipoprotein; DLP12 prophage YP_002386242.1 828257 R 585034 CDS YP_002386243.1 218553330 7127572 829496..830041 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92334985; Product type h : extrachromosomal origin; DNA packaging protein; DLP12 prophage 830041 nohB 7127572 nohB Escherichia coli IAI1 DNA packaging protein; DLP12 prophage YP_002386243.1 829496 D 585034 CDS YP_002386244.1 218553331 7127894 830016..831941 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Terminase large subunit from bacteriophage origin 831941 A 7127894 A Escherichia coli IAI1 Terminase large subunit from bacteriophage origin YP_002386244.1 830016 D 585034 CDS YP_002386245.1 218553332 7125673 831938..832144 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11302702; Product type h : extrachromosomal origin; Head-to-tail joining protein W (gpW) from bacteriophage origin 832144 W 7125673 W Escherichia coli IAI1 Head-to-tail joining protein W (gpW) from bacteriophage origin YP_002386245.1 831938 D 585034 CDS YP_002386246.1 218553333 7125572 832141..833742 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Portal protein; minor capsid protein 833742 B 7125572 B Escherichia coli IAI1 Portal protein; minor capsid protein YP_002386246.1 832141 D 585034 CDS YP_002386247.1 218553334 7126285 833723..835042 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Minor capsid protein 835042 C 7126285 C Escherichia coli IAI1 Minor capsid protein YP_002386247.1 833723 D 585034 CDS YP_002386248.1 218553335 7124429 835046..835384 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Head decoration protein from bacteriophage origin 835384 D 7124429 D Escherichia coli IAI1 Head decoration protein from bacteriophage origin YP_002386248.1 835046 D 585034 CDS YP_002386249.1 218553336 7126906 835413..836465 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Major head coat protein from bacteriophage origin 836465 E 7126906 E Escherichia coli IAI1 Major head coat protein from bacteriophage origin YP_002386249.1 835413 D 585034 CDS YP_002386250.1 218553337 7125037 836468..836902 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; DNA packaging protein from bacteriophage origin 836902 fI 7125037 fI Escherichia coli IAI1 DNA packaging protein from bacteriophage origin YP_002386250.1 836468 D 585034 CDS YP_002386251.1 218553338 7127104 836914..837267 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin; Tail attachment protein (Minor capsid protein FII) from bacteriophage origin 837267 fII 7127104 fII Escherichia coli IAI1 Tail attachment protein (Minor capsid protein FII) from bacteriophage origin YP_002386251.1 836914 D 585034 CDS YP_002386252.1 218553339 7127108 837279..837857 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein Z (GpZ) 837857 7127108 ECIAI1_0790 Escherichia coli IAI1 Minor tail protein Z (GpZ) YP_002386252.1 837279 D 585034 CDS YP_002386253.1 218553340 7126956 837854..838249 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein U 838249 7126956 ECIAI1_0791 Escherichia coli IAI1 Minor tail protein U YP_002386253.1 837854 D 585034 CDS YP_002386254.1 218553341 7126957 838227..838997 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major tail protein V 838997 7126957 ECIAI1_0792 Escherichia coli IAI1 Major tail protein V YP_002386254.1 838227 D 585034 CDS YP_002386255.1 218553342 7126958 839013..839435 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein G 839435 7126958 ECIAI1_0793 Escherichia coli IAI1 Minor tail protein G YP_002386255.1 839013 D 585034 CDS YP_002386256.1 218553343 7126959 839417..839851 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein T 839851 7126959 ECIAI1_0794 Escherichia coli IAI1 Minor tail protein T YP_002386256.1 839417 D 585034 CDS YP_002386257.1 218553344 7126960 839844..842423 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein H 842423 7126960 ECIAI1_0795 Escherichia coli IAI1 Minor tail protein H YP_002386257.1 839844 D 585034 CDS YP_002386258.1 218553345 7126961 842341..842499 1 NC_011741.1 hypothetical protein 842499 7126961 ECIAI1_0796 Escherichia coli IAI1 hypothetical protein YP_002386258.1 842341 D 585034 CDS YP_002386259.1 218553346 7126962 842420..842749 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein M 842749 7126962 ECIAI1_0797 Escherichia coli IAI1 Minor tail protein M YP_002386259.1 842420 D 585034 CDS YP_002386260.1 218553347 7126963 842749..843447 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein L 843447 7126963 ECIAI1_0798 Escherichia coli IAI1 Minor tail protein L YP_002386260.1 842749 D 585034 CDS YP_002386261.1 218553348 7126964 843453..844196 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber component K of prophage 844196 7126964 ECIAI1_0799 Escherichia coli IAI1 putative tail fiber component K of prophage YP_002386261.1 843453 D 585034 CDS YP_002386262.1 218553349 7126965 844094..844765 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Tail assembly protein I 844765 7126965 ECIAI1_0800 Escherichia coli IAI1 Tail assembly protein I YP_002386262.1 844094 D 585034 CDS YP_002386263.1 218553350 7126966 844826..848305 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J 848305 7126966 ECIAI1_0801 Escherichia coli IAI1 Host specificity protein J YP_002386263.1 844826 D 585034 CDS YP_002386264.1 218553351 7126967 848374..848973 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Lom-like outer membrane protein of phage origin 848973 7126967 ECIAI1_0802 Escherichia coli IAI1 putative Lom-like outer membrane protein of phage origin YP_002386264.1 848374 D 585034 CDS YP_002386265.1 218553352 7128622 849032..852793 1 NC_011741.1 hypothetical protein 852793 7128622 ECIAI1_0803 Escherichia coli IAI1 hypothetical protein YP_002386265.1 849032 D 585034 CDS YP_002386266.1 218553353 7128623 complement(853588..853755) 1 NC_011741.1 hypothetical protein 853755 7128623 ECIAI1_0804 Escherichia coli IAI1 hypothetical protein YP_002386266.1 853588 R 585034 CDS YP_002386267.1 218553354 7128624 854470..855222 1 NC_011741.1 putative AraC-type regulatory protein encoded in prophage CP-933H 855222 7128624 ECIAI1_0805 Escherichia coli IAI1 putative AraC-type regulatory protein encoded in prophage CP-933H YP_002386267.1 854470 D 585034 CDS YP_002386268.1 218553355 7128625 complement(855264..855629) 1 NC_011741.1 hypothetical protein 855629 7128625 ECIAI1_0806 Escherichia coli IAI1 hypothetical protein YP_002386268.1 855264 R 585034 CDS YP_002386269.1 218553356 7126654 complement(856325..856801) 1 NC_011741.1 YbhB; similar to rat and human kinase inhibitory proteins; putative kinase inhibitor protein 856801 ybhB 7126654 ybhB Escherichia coli IAI1 putative kinase inhibitor protein YP_002386269.1 856325 R 585034 CDS YP_002386270.1 218553357 7124833 complement(856860..858149) 1 NC_011741.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine--8-amino-7-oxononanoate transaminase 858149 bioA 7124833 bioA Escherichia coli IAI1 adenosylmethionine--8-amino-7-oxononanoate transaminase YP_002386270.1 856860 R 585034 CDS YP_002386271.1 218553358 7124407 858236..859276 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11834738, 12475249, 14704425, 14967041, 20250955, 89066784, 94170810, 94190882, 97382445, 11686925; Product type e : enzyme; biotin synthase 859276 bioB 7124407 bioB Escherichia coli IAI1 biotin synthase YP_002386271.1 858236 D 585034 CDS YP_002386272.1 218553359 7124408 859273..860427 1 NC_011741.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 860427 bioF 7124408 bioF Escherichia coli IAI1 8-amino-7-oxononanoate synthase YP_002386272.1 859273 D 585034 CDS YP_002386273.1 218553360 7124411 860414..861169 1 NC_011741.1 putative methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 861169 bioC 7124411 bioC Escherichia coli IAI1 biotin biosynthesis protein BioC YP_002386273.1 860414 D 585034 CDS YP_002386274.1 218553361 7124409 861162..861839 1 NC_011741.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 861839 bioD 7124409 bioD Escherichia coli IAI1 dithiobiotin synthetase YP_002386274.1 861162 D 585034 CDS YP_002386275.1 218553362 7124410 862418..864439 1 NC_011741.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 864439 uvrB 7124410 uvrB Escherichia coli IAI1 excinuclease ABC subunit B YP_002386275.1 862418 D 585034 CDS YP_002386276.1 218553363 7125556 complement(864631..865539) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16272399; Product type pe : putative enzyme; putative transferase 865539 ybhK 7125556 ybhK Escherichia coli IAI1 putative transferase YP_002386276.1 864631 R 585034 CDS YP_002386277.1 218553364 7124841 865936..866925 1 NC_011741.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 866925 moaA 7124841 moaA Escherichia coli IAI1 molybdenum cofactor biosynthesis protein A YP_002386277.1 865936 D 585034 CDS YP_002386278.1 218553365 7124290 866947..867459 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93368423; Product type pf : putative factor; molybdopterin biosynthesis protein B 867459 moaB 7124290 moaB Escherichia coli IAI1 molybdopterin biosynthesis protein B YP_002386278.1 866947 D 585034 CDS YP_002386279.1 218553366 7124291 867462..867947 1 NC_011741.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 867947 moaC 7124291 moaC Escherichia coli IAI1 molybdenum cofactor biosynthesis protein MoaC YP_002386279.1 867462 D 585034 CDS YP_002386280.1 218553367 7124292 867940..868185 1 NC_011741.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 868185 moaD 7124292 moaD Escherichia coli IAI1 molybdopterin synthase small subunit YP_002386280.1 867940 D 585034 CDS YP_002386281.1 218553368 7124293 868187..868639 1 NC_011741.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin guanine dinucleotide biosynthesis protein MoaE 868639 moaE 7124293 moaE Escherichia coli IAI1 molybdopterin guanine dinucleotide biosynthesis protein MoaE YP_002386281.1 868187 D 585034 CDS YP_002386282.1 218553369 7124294 868776..869480 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 869480 ybhL 7124294 ybhL Escherichia coli IAI1 hypothetical protein YP_002386282.1 868776 D 585034 CDS YP_002386283.1 218553370 7124842 869625..870329 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 870329 7124842 ECIAI1_0822 Escherichia coli IAI1 hypothetical protein YP_002386283.1 869625 D 585034 CDS YP_002386284.1 218553371 7128627 870399..871112 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 871112 ybhM 7128627 ybhM Escherichia coli IAI1 hypothetical protein YP_002386284.1 870399 D 585034 CDS YP_002386285.1 218553372 7124843 complement(871148..872104) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 872104 ybhN 7124843 ybhN Escherichia coli IAI1 hypothetical protein YP_002386285.1 871148 R 585034 CDS YP_002386286.1 218553373 7124844 complement(872104..873345) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20102623, 10634942; Product type e : enzyme; cardiolipin synthase 2 873345 ybhO 7124844 ybhO Escherichia coli IAI1 cardiolipin synthase 2 YP_002386286.1 872104 R 585034 CDS YP_002386287.1 218553374 7124845 complement(873342..874103) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal-dependent hydrolase 874103 ybhP 7124845 ybhP Escherichia coli IAI1 putative metal-dependent hydrolase YP_002386287.1 873342 R 585034 CDS YP_002386288.1 218553375 7124846 874236..874646 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 874646 ybhQ 7124846 ybhQ Escherichia coli IAI1 hypothetical protein YP_002386288.1 874236 D 585034 CDS YP_002386289.1 218553376 7124847 complement(874608..875714) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease 875714 ybhR 7124847 ybhR Escherichia coli IAI1 putative ABC transporter permease YP_002386289.1 874608 R 585034 CDS YP_002386290.1 218553377 7124848 complement(875725..876858) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease 876858 ybhS 7124848 ybhS Escherichia coli IAI1 putative ABC transporter permease YP_002386290.1 875725 R 585034 CDS YP_002386291.1 218553378 7124849 complement(876851..878587) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 878587 ybhF 7124849 ybhF Escherichia coli IAI1 putative ABC transporter ATP-binding protein YP_002386291.1 876851 R 585034 CDS YP_002386292.1 218553379 7124836 complement(878580..879578) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16092522; Product type pt : putative transporter; hypothetical protein 879578 ybhG 7124836 ybhG Escherichia coli IAI1 hypothetical protein YP_002386292.1 878580 R 585034 CDS YP_002386293.1 218553380 7124837 complement(879578..880249) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 880249 ybiH 7124837 ybiH Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002386293.1 879578 R 585034 CDS YP_002386294.1 218553381 7124854 880478..881842 1 NC_011741.1 this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 881842 rhlE 7124854 rhlE Escherichia coli IAI1 ATP-dependent RNA helicase RhlE YP_002386294.1 880478 D 585034 CDS YP_002386295.1 218553382 7124980 881849..882049 1 NC_011741.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 882049 7124980 ECIAI1_0834 Escherichia coli IAI1 hypothetical protein YP_002386295.1 881849 D 585034 CDS YP_002386296.1 218553383 7128628 882113..883093 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 883093 7128628 ECIAI1_0835 Escherichia coli IAI1 transposase, IS110 family YP_002386296.1 882113 D 585034 CDS YP_002386297.1 218553384 7128629 complement(883353..883835) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 883835 ybiA 7128629 ybiA Escherichia coli IAI1 hypothetical protein YP_002386297.1 883353 R 585034 CDS YP_002386298.1 218553385 7124851 883955..886105 1 NC_011741.1 helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 886105 dinG 7124851 dinG Escherichia coli IAI1 ATP-dependent DNA helicase DinG YP_002386298.1 883955 D 585034 CDS YP_002386299.1 218553386 7124589 886133..887095 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; glycosyl transferase family protein 887095 ybiB 7124589 ybiB Escherichia coli IAI1 glycosyl transferase family protein YP_002386299.1 886133 D 585034 CDS YP_002386300.1 218553387 7124852 887236..888318 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8405966; Product type pe : putative enzyme; hypothetical protein 888318 ybiC 7124852 ybiC Escherichia coli IAI1 hypothetical protein YP_002386300.1 887236 D 585034 CDS YP_002386301.1 218553388 7124853 complement(888547..888807) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 888807 ybiJ 7124853 ybiJ Escherichia coli IAI1 hypothetical protein YP_002386301.1 888547 R 585034 CDS YP_002386302.1 218553389 7124856 complement(889072..889338) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 889338 ybiI 7124856 ybiI Escherichia coli IAI1 hypothetical protein YP_002386302.1 889072 R 585034 CDS YP_002386303.1 218553390 7124855 complement(889412..890089) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative hydroxylase 890089 ybiX 7124855 ybiX Escherichia coli IAI1 putative hydroxylase YP_002386303.1 889412 R 585034 CDS YP_002386304.1 218553391 7124705 complement(890131..892413) 1 NC_011741.1 Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein; catecholate siderophore receptor Fiu 892413 fiu 7124705 fiu Escherichia coli IAI1 catecholate siderophore receptor Fiu YP_002386304.1 890131 R 585034 CDS YP_002386305.1 218553392 7127121 complement(892678..893082) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 893082 ybiM 7127121 ybiM Escherichia coli IAI1 hypothetical protein YP_002386305.1 892678 R 585034 CDS YP_002386306.1 218553393 7124857 893214..894140 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative SAM-dependent methyltransferase 894140 ybiN 7124857 ybiN Escherichia coli IAI1 putative SAM-dependent methyltransferase YP_002386306.1 893214 D 585034 CDS YP_002386307.1 218553394 7124858 complement(894137..896362) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 896362 ybiO 7124858 ybiO Escherichia coli IAI1 hypothetical protein YP_002386307.1 894137 R 585034 CDS YP_002386308.1 218553395 7124859 complement(896479..897201) 1 NC_011741.1 similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein 897201 glnQ 7124859 glnQ Escherichia coli IAI1 glutamine ABC transporter ATP-binding protein YP_002386308.1 896479 R 585034 CDS YP_002386309.1 218553396 7128330 complement(897198..897857) 1 NC_011741.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease 897857 glnP 7128330 glnP Escherichia coli IAI1 glutamine ABC transporter permease YP_002386309.1 897198 R 585034 CDS YP_002386310.1 218553397 7128329 complement(897996..898742) 1 NC_011741.1 similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein 898742 glnH 7128329 glnH Escherichia coli IAI1 glutamine ABC transporter periplasmic protein YP_002386310.1 897996 R 585034 CDS YP_002386311.1 218553398 7128326 complement(899146..899649) 1 NC_011741.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps 899649 dps 7128326 dps Escherichia coli IAI1 DNA starvation/stationary phase protection protein Dps YP_002386311.1 899146 R 585034 CDS YP_002386312.1 218553399 7124621 complement(899948..900835) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12648727, 8021175; Product type t : transporter; threonine and homoserine efflux system 900835 rhtA 7124621 rhtA Escherichia coli IAI1 threonine and homoserine efflux system YP_002386312.1 899948 R 585034 CDS YP_002386313.1 218553400 7124989 901187..901702 1 NC_011741.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 901702 ompX 7124989 ompX Escherichia coli IAI1 outer membrane protein X YP_002386313.1 901187 D 585034 CDS YP_002386314.1 218553401 7125986 complement(901751..903334) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16514146; Product type pe : putative enzyme; hypothetical protein 903334 ybiP 7125986 ybiP Escherichia coli IAI1 hypothetical protein YP_002386314.1 901751 R 585034 CDS YP_002386315.1 218553402 7124647 903920..904387 1 NC_011741.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 904387 mntR 7124647 mntR Escherichia coli IAI1 manganese transport regulator MntR YP_002386315.1 903920 D 585034 CDS YP_002386316.1 218553403 7124289 904384..905502 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 905502 ybiR 7124289 ybiR Escherichia coli IAI1 putative transporter YP_002386316.1 904384 D 585034 CDS YP_002386317.1 218553404 7124861 complement(905561..906481) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10493123, 9298646; hypothetical protein 906481 ybiS 7124861 ybiS Escherichia coli IAI1 hypothetical protein YP_002386317.1 905561 R 585034 CDS YP_002386318.1 218553405 7124862 906700..908292 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11916677; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 908292 ybiT 7124862 ybiT Escherichia coli IAI1 putative ABC transporter ATP-binding protein YP_002386318.1 906700 D 585034 CDS YP_002386319.1 218553406 7124701 908571..909551 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 909551 7124701 ECIAI1_0859 Escherichia coli IAI1 transposase, IS110 family YP_002386319.1 908571 D 585034 CDS YP_002386320.1 218553407 7128630 complement(909807..911072) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 911072 ybiU 7128630 ybiU Escherichia coli IAI1 hypothetical protein YP_002386320.1 909807 R 585034 CDS YP_002386321.1 218553408 7124702 complement(911224..912039) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15657928; Product type e : enzyme; type II HAD phosphatase 912039 ybiV 7124702 ybiV Escherichia coli IAI1 type II HAD phosphatase YP_002386321.1 911224 R 585034 CDS YP_002386322.1 218553409 7124703 complement(912185..914617) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16218870; Product type pe : putative enzyme; putative glycyl radical cofactor protein 914617 ybiW 7124703 ybiW Escherichia coli IAI1 putative glycyl radical cofactor protein YP_002386322.1 912185 R 585034 CDS YP_002386323.1 218553410 7124704 complement(914623..915549) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15581584; Product type pe : putative enzyme; putative AdoMet-dependent glycyl radical activating enzyme 915549 ybiY 7124704 ybiY Escherichia coli IAI1 putative AdoMet-dependent glycyl radical activating enzyme YP_002386323.1 914623 R 585034 CDS YP_002386324.1 218553411 7124706 915653..916315 1 NC_011741.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 916315 fsaA 7124706 fsaA Escherichia coli IAI1 fructose-6-phosphate aldolase YP_002386324.1 915653 D 585034 CDS YP_002386325.1 218553412 7128228 complement(916494..917243) 1 NC_011741.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 917243 moeB 7128228 moeB Escherichia coli IAI1 molybdopterin biosynthesis protein MoeB YP_002386325.1 916494 R 585034 CDS YP_002386326.1 218553413 7124303 complement(917243..918478) 1 NC_011741.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA 918478 moeA 7124303 moeA Escherichia coli IAI1 molybdopterin biosynthesis protein MoeA YP_002386326.1 917243 R 585034 CDS YP_002386327.1 218553414 7124302 918682..919647 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15159592, 20508248, 3045084, 7984428; Product type e : enzyme; L-asparaginase 919647 iaaA 7124302 iaaA Escherichia coli IAI1 L-asparaginase YP_002386327.1 918682 D 585034 CDS YP_002386328.1 218553415 7126036 919667..921505 1 NC_011741.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 921505 yliA 7126036 yliA Escherichia coli IAI1 glutathione transporter ATP-binding protein YP_002386328.1 919667 D 585034 CDS YP_002386329.1 218553416 7126661 921525..923063 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17366475; Product type pt : putative transporter; putative peptide ABC transporter periplasmic-binding protein 923063 yliB 7126661 yliB Escherichia coli IAI1 putative peptide ABC transporter periplasmic-binding protein YP_002386329.1 921525 D 585034 CDS YP_002386330.1 218553417 7126662 923081..924001 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative peptide ABC transporter permease 924001 yliC 7126662 yliC Escherichia coli IAI1 putative peptide ABC transporter permease YP_002386330.1 923081 D 585034 CDS YP_002386331.1 218553418 7126663 924004..924915 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative peptide ABC transporter permease 924915 yliD 7126663 yliD Escherichia coli IAI1 putative peptide ABC transporter permease YP_002386331.1 924004 D 585034 CDS YP_002386332.1 218553419 7126664 925093..927441 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 927441 yliE 7126664 yliE Escherichia coli IAI1 hypothetical protein YP_002386332.1 925093 D 585034 CDS YP_002386333.1 218553420 7126665 927449..928777 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type pe : putative enzyme; putative diguanylate cyclase 928777 yliF 7126665 yliF Escherichia coli IAI1 putative diguanylate cyclase YP_002386333.1 927449 D 585034 CDS YP_002386334.1 218553421 7126666 complement(928824..930149) 1 NC_011741.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase 930149 rimO 7126666 rimO Escherichia coli IAI1 ribosomal protein S12 methylthiotransferase YP_002386334.1 928824 R 585034 CDS YP_002386335.1 218553422 7126667 930362..930745 1 NC_011741.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 930745 bssR 7126667 bssR Escherichia coli IAI1 biofilm formation regulatory protein BssR YP_002386335.1 930362 D 585034 CDS YP_002386336.1 218553423 7124421 930856..931971 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16522795, 16864586; Product type e : enzyme; PQQ-dependent aldose sugar dehydrogenase 931971 yliI 7124421 yliI Escherichia coli IAI1 PQQ-dependent aldose sugar dehydrogenase YP_002386336.1 930856 D 585034 CDS YP_002386337.1 218553424 7126668 complement(931968..932594) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase 932594 yliJ 7126668 yliJ Escherichia coli IAI1 putative glutathione S-transferase YP_002386337.1 931968 R 585034 CDS YP_002386338.1 218553425 7126669 932840..934042 1 NC_011741.1 penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase fraction C 934042 dacC 7126669 dacC Escherichia coli IAI1 D-alanyl-D-alanine carboxypeptidase fraction C YP_002386338.1 932840 D 585034 CDS YP_002386339.1 218553426 7126910 complement(934089..934847) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89231635, 89336786, 92231401, 2994018; Product type r : regulator; DNA-binding transcriptional repressor DeoR 934847 deoR 7126910 deoR Escherichia coli IAI1 DNA-binding transcriptional repressor DeoR YP_002386339.1 934089 R 585034 CDS YP_002386340.1 218553427 7124567 complement(934905..935501) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15778224; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase 935501 ybjG 7124567 ybjG Escherichia coli IAI1 undecaprenyl pyrophosphate phosphatase YP_002386340.1 934905 R 585034 CDS YP_002386341.1 218553428 7124710 935786..937018 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10022825, 12578981, 14688269, 21217867, 21450803, 9079913, 9644262, 99030337, 8655497; Product type t : transporter; multidrug efflux system protein 937018 cmr 7124710 cmr Escherichia coli IAI1 multidrug efflux system protein YP_002386341.1 935786 D 585034 CDS YP_002386342.1 218553429 7126339 complement(937059..937343) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 937343 ybjH 7126339 ybjH Escherichia coli IAI1 hypothetical protein YP_002386342.1 937059 R 585034 CDS YP_002386343.1 218553430 7124711 complement(937429..938244) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme; putative phosphatase 938244 ybjI 7124711 ybjI Escherichia coli IAI1 putative phosphatase YP_002386343.1 937429 R 585034 CDS YP_002386344.1 218553431 7124712 complement(938244..939452) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 939452 ybjJ 7124712 ybjJ Escherichia coli IAI1 putative transporter YP_002386344.1 938244 R 585034 CDS YP_002386345.1 218553432 7124713 939536..940072 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 940072 ybjK 7124713 ybjK Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002386345.1 939536 D 585034 CDS YP_002386346.1 218553433 7124648 complement(940247..941932) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 941932 ybjL 7124648 ybjL Escherichia coli IAI1 hypothetical protein YP_002386346.1 940247 R 585034 CDS YP_002386347.1 218553434 7124715 942202..942579 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 942579 ybjM 7124715 ybjM Escherichia coli IAI1 hypothetical protein YP_002386347.1 942202 D 585034 CDS YP_002386348.1 218553435 7124716 complement(942609..942866) 1 NC_011741.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 1 942866 grxA 7124716 grxA Escherichia coli IAI1 glutaredoxin 1 YP_002386348.1 942609 R 585034 CDS YP_002386349.1 218553436 7128468 943026..943313 1 NC_011741.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 943313 ybjC 7128468 ybjC Escherichia coli IAI1 hypothetical protein YP_002386349.1 943026 D 585034 CDS YP_002386350.1 218553437 7124707 943297..944019 1 NC_011741.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 944019 nfsA 7124707 nfsA Escherichia coli IAI1 nitroreductase A YP_002386350.1 943297 D 585034 CDS YP_002386351.1 218553438 7127872 944080..944982 1 NC_011741.1 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 944982 rimK 7127872 rimK Escherichia coli IAI1 ribosomal protein S6 modification protein YP_002386351.1 944080 D 585034 CDS YP_002386352.1 218553439 7125003 945070..945546 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 945546 ybjN 7125003 ybjN Escherichia coli IAI1 hypothetical protein YP_002386352.1 945070 D 585034 CDS YP_002386353.1 218553440 7124717 945897..947009 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992, 9651355, 9298646, 8416922; Product type t : transporter; putrescine ABC transporter periplasmic-binding protein 947009 potF 7124717 potF Escherichia coli IAI1 putrescine ABC transporter periplasmic-binding protein YP_002386353.1 945897 D 585034 CDS YP_002386354.1 218553441 7126118 947104..948237 1 NC_011741.1 part of the PotFGHI ATP-dependent putrescine transporter; putrescine transporter ATP-binding subunit 948237 potG 7126118 potG Escherichia coli IAI1 putrescine transporter ATP-binding subunit YP_002386354.1 947104 D 585034 CDS YP_002386355.1 218553442 7126119 948247..949200 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992; Product type t : transporter; putrescine ABC transporter membrane protein 949200 potH 7126119 potH Escherichia coli IAI1 putrescine ABC transporter membrane protein YP_002386355.1 948247 D 585034 CDS YP_002386356.1 218553443 7126120 949197..950042 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992; Product type t : transporter; putrescine ABC transporter membrane protein 950042 potI 7126120 potI Escherichia coli IAI1 putrescine ABC transporter membrane protein YP_002386356.1 949197 D 585034 CDS YP_002386357.1 218553444 7126121 950102..950590 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 950590 ybjO 7126121 ybjO Escherichia coli IAI1 hypothetical protein YP_002386357.1 950102 D 585034 CDS YP_002386358.1 218553445 7124718 950631..951758 1 NC_011741.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 951758 rumB 7124718 rumB Escherichia coli IAI1 23S rRNA methyluridine methyltransferase YP_002386358.1 950631 D 585034 CDS YP_002386359.1 218553446 7124634 complement(951933..952664) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93273744, 9298646, 9600841, 8801422; Product type t : transporter; arginine ABC transporter periplasmic-binding protein 952664 artJ 7124634 artJ Escherichia coli IAI1 arginine ABC transporter periplasmic-binding protein YP_002386359.1 951933 R 585034 CDS YP_002386360.1 218553447 7125821 complement(952956..953624) 1 NC_011741.1 with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM 953624 artM 7125821 artM Escherichia coli IAI1 arginine transporter permease subunit ArtM YP_002386360.1 952956 R 585034 CDS YP_002386361.1 218553448 7125822 complement(953624..954340) 1 NC_011741.1 with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ 954340 artQ 7125822 artQ Escherichia coli IAI1 arginine transporter permease subunit ArtQ YP_002386361.1 953624 R 585034 CDS YP_002386362.1 218553449 7125824 complement(954347..955078) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93273744, 9298646, 9600841, 8801422, 9740056; Product type t : transporter; arginine ABC transporter periplasmic-binding protein 955078 artI 7125824 artI Escherichia coli IAI1 arginine ABC transporter periplasmic-binding protein YP_002386362.1 954347 R 585034 CDS YP_002386363.1 218553450 7125820 complement(955096..955824) 1 NC_011741.1 With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit 955824 artP 7125820 artP Escherichia coli IAI1 arginine transporter ATP-binding subunit YP_002386363.1 955096 R 585034 CDS YP_002386364.1 218553451 7125823 complement(956042..956557) 1 NC_011741.1 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS; hypothetical protein 956557 ybjP 7125823 ybjP Escherichia coli IAI1 hypothetical protein YP_002386364.1 956042 R 585034 CDS YP_002386365.1 218553452 7124719 956683..957006 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 957006 ybjQ 7124719 ybjQ Escherichia coli IAI1 hypothetical protein YP_002386365.1 956683 D 585034 CDS YP_002386366.1 218553453 7124720 957003..957833 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cell wall amidase and lipoprotein 957833 ybjR 7124720 ybjR Escherichia coli IAI1 putative cell wall amidase and lipoprotein YP_002386366.1 957003 D 585034 CDS YP_002386367.1 218553454 7124721 complement(957830..958843) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P)H-binding oxidoreductase 958843 ybjS 7124721 ybjS Escherichia coli IAI1 putative NAD(P)H-binding oxidoreductase YP_002386367.1 957830 R 585034 CDS YP_002386368.1 218553455 7124722 complement(958942..960372) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 960372 ybjT 7124722 ybjT Escherichia coli IAI1 hypothetical protein YP_002386368.1 958942 R 585034 CDS YP_002386369.1 218553456 7124723 complement(960383..961384) 1 NC_011741.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase 961384 ltaE 7124723 ltaE Escherichia coli IAI1 L-threonine aldolase YP_002386369.1 960383 R 585034 CDS YP_002386370.1 218553457 7127640 complement(961421..963139) 1 NC_011741.1 catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase 963139 poxB 7127640 poxB Escherichia coli IAI1 pyruvate dehydrogenase YP_002386370.1 961421 R 585034 CDS YP_002386371.1 218553458 7126123 complement(963272..964240) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20117674; Product type e : enzyme; HCP oxidoreductase, NADH-dependent 964240 hcr 7126123 hcr Escherichia coli IAI1 HCP oxidoreductase, NADH-dependent YP_002386371.1 963272 R 585034 CDS YP_002386372.1 218553459 7128497 complement(964252..965904) 1 NC_011741.1 catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase 965904 hcp 7128497 hcp Escherichia coli IAI1 hydroxylamine reductase YP_002386372.1 964252 R 585034 CDS YP_002386373.1 218553460 7128496 complement(966048..966947) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 966947 ybjE 7128496 ybjE Escherichia coli IAI1 putative transporter YP_002386373.1 966048 R 585034 CDS YP_002386374.1 218553461 7124709 complement(967404..968099) 1 NC_011741.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z 968099 aqpZ 7124709 aqpZ Escherichia coli IAI1 aquaporin Z YP_002386374.1 967404 R 585034 CDS YP_002386375.1 218553462 7125774 968525..970183 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 970183 ybjD 7125774 ybjD Escherichia coli IAI1 hypothetical protein YP_002386375.1 968525 D 585034 CDS YP_002386376.1 218553463 7124708 complement(970180..971172) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 971172 ybjX 7124708 ybjX Escherichia coli IAI1 hypothetical protein YP_002386376.1 970180 R 585034 CDS YP_002386377.1 218553464 7124724 971287..972402 1 NC_011741.1 confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 972402 macA 7124724 macA Escherichia coli IAI1 macrolide transporter subunit MacA YP_002386377.1 971287 D 585034 CDS YP_002386378.1 218553465 7127650 972399..974345 1 NC_011741.1 with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease 974345 macB 7127650 macB Escherichia coli IAI1 macrolide transporter ATP-binding /permease YP_002386378.1 972399 D 585034 CDS YP_002386379.1 218553466 7127651 complement(974418..974642) 1 NC_011741.1 inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD 974642 cspD 7127651 cspD Escherichia coli IAI1 stationary phase/starvation inducible regulatory protein CspD YP_002386379.1 974418 R 585034 CDS YP_002386380.1 218553467 7125934 974965..975285 1 NC_011741.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 975285 clpS 7125934 clpS Escherichia coli IAI1 ATP-dependent Clp protease adaptor protein ClpS YP_002386380.1 974965 D 585034 CDS YP_002386381.1 218553468 7126335 975316..977592 1 NC_011741.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit 977592 clpA 7126335 clpA Escherichia coli IAI1 ATP-dependent Clp protease ATP-binding subunit YP_002386381.1 975316 D 585034 CDS YP_002386382.1 218553469 7126332 complement(977649..977969) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 977969 7126332 ECIAI1_0923 Escherichia coli IAI1 hypothetical protein YP_002386382.1 977649 R 585034 CDS YP_002386383.1 218553470 7128059 complement(978336..978554) 1 NC_011741.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 978554 infA 7128059 infA Escherichia coli IAI1 translation initiation factor IF-1 YP_002386383.1 978336 R 585034 CDS YP_002386384.1 218553471 7126064 complement(978839..979543) 1 NC_011741.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase 979543 aat 7126064 aat Escherichia coli IAI1 leucyl/phenylalanyl-tRNA--protein transferase YP_002386384.1 978839 R 585034 CDS YP_002386385.1 218553472 7125684 complement(979585..981306) 1 NC_011741.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component 981306 cydC 7125684 cydC Escherichia coli IAI1 cysteine/glutathione ABC transporter membrane/ATP-binding component YP_002386385.1 979585 R 585034 CDS YP_002386386.1 218553473 7126876 complement(981307..983073) 1 NC_011741.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component 983073 cydD 7126876 cydD Escherichia coli IAI1 cysteine/glutathione ABC transporter membrane/ATP-binding component YP_002386386.1 981307 R 585034 CDS YP_002386387.1 218553474 7126877 complement(983196..984161) 1 NC_011741.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase 984161 trxB 7126877 trxB Escherichia coli IAI1 thioredoxin reductase YP_002386387.1 983196 R 585034 CDS YP_002386388.1 218553475 7127507 984706..985200 1 NC_011741.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 985200 lrp 7127507 lrp Escherichia coli IAI1 leucine-responsive transcriptional regulator YP_002386388.1 984706 D 585034 CDS YP_002386389.1 218553476 7127631 985335..989480 1 NC_011741.1 DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 989480 ftsK 7127631 ftsK Escherichia coli IAI1 DNA translocase FtsK YP_002386389.1 985335 D 585034 CDS YP_002386390.1 218553477 7128237 989632..990246 1 NC_011741.1 participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 990246 lolA 7128237 lolA Escherichia coli IAI1 outer-membrane lipoprotein carrier protein YP_002386390.1 989632 D 585034 CDS YP_002386391.1 218553478 7126433 990257..991600 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7567469, 7628437, 11459952, 11029431; Product type cp : cell process; recombination factor protein RarA 991600 ycaJ 7126433 ycaJ Escherichia coli IAI1 recombination factor protein RarA YP_002386391.1 990257 D 585034 CDS YP_002386392.1 218553479 7124728 991691..992983 1 NC_011741.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 992983 serS 7124728 serS Escherichia coli IAI1 seryl-tRNA synthetase YP_002386392.1 991691 D 585034 CDS YP_002386393.1 218553480 7127911 993222..995666 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91008971, 92011349, 94171715, 10801884, 3062312; Product type e : enzyme; dimethyl sulfoxide reductase, anaerobic subunit A 995666 dmsA 7127911 dmsA Escherichia coli IAI1 dimethyl sulfoxide reductase, anaerobic subunit A YP_002386393.1 993222 D 585034 CDS YP_002386394.1 218553481 7124600 995677..996294 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91070067, 91355180, 92011349, 3062312; Product type e : enzyme; dimethyl sulfoxide reductase, anaerobic subunit B 996294 dmsB 7124600 dmsB Escherichia coli IAI1 dimethyl sulfoxide reductase, anaerobic subunit B YP_002386394.1 995677 D 585034 CDS YP_002386395.1 218553482 7124601 996296..997159 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91008971, 92011349, 3062312, 8429002; Product type e : enzyme; dimethyl sulfoxide reductase, anaerobic subunit C 997159 dmsC 7124601 dmsC Escherichia coli IAI1 dimethyl sulfoxide reductase, anaerobic subunit C YP_002386395.1 996296 D 585034 CDS YP_002386396.1 218553483 7124602 complement(997195..997821) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9782055, 3062312, 11714269; Product type pe : putative enzyme; putative hydrolase 997821 ycaC 7124602 ycaC Escherichia coli IAI1 putative hydrolase YP_002386396.1 997195 R 585034 CDS YP_002386397.1 218553484 7124725 998136..999284 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS family transporter protein 999284 ycaD 7124725 ycaD Escherichia coli IAI1 putative MFS family transporter protein YP_002386397.1 998136 D 585034 CDS YP_002386398.1 218553485 7124726 999494..1000924 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type pt : putative transporter; putative transporter 1000924 ycaM 7124726 ycaM Escherichia coli IAI1 putative transporter YP_002386398.1 999494 D 585034 CDS YP_002386399.1 218553486 7124731 complement(1000925..1001833) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1001833 ycaN 7124731 ycaN Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002386399.1 1000925 R 585034 CDS YP_002386400.1 218553487 7124732 1001933..1002523 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3053170; Product type pe : putative enzyme; hypothetical protein 1002523 ycaK 7124732 ycaK Escherichia coli IAI1 hypothetical protein YP_002386400.1 1001933 D 585034 CDS YP_002386401.1 218553488 7124729 complement(1002605..1003345) 1 NC_011741.1 activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 1003345 pflA 7124729 pflA Escherichia coli IAI1 pyruvate formate lyase-activating enzyme 1 YP_002386401.1 1002605 R 585034 CDS YP_002386402.1 218553489 7124180 complement(1003537..1005819) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91064082, 92276323, 10504733, 1310545, 2651404, 3053170, 9629924; Product type e : enzyme; pyruvate formate lyase I 1005819 pflB 7124180 pflB Escherichia coli IAI1 pyruvate formate lyase I YP_002386402.1 1003537 R 585034 CDS YP_002386403.1 218553490 7124181 complement(1005874..1006731) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293770, 2651404; Product type t : transporter; formate transporter 1006731 focA 7124181 focA Escherichia coli IAI1 formate transporter YP_002386403.1 1005874 R 585034 CDS YP_002386404.1 218553491 7127256 complement(1007137..1008897) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1008897 ycaO 7127256 ycaO Escherichia coli IAI1 hypothetical protein YP_002386404.1 1007137 R 585034 CDS YP_002386405.1 218553492 7124733 1009027..1009719 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1009719 ycaP 7124733 ycaP Escherichia coli IAI1 hypothetical protein YP_002386405.1 1009027 D 585034 CDS YP_002386406.1 218553493 7124734 1009918..1011006 1 NC_011741.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 1011006 serC 7124734 serC Escherichia coli IAI1 phosphoserine aminotransferase YP_002386406.1 1009918 D 585034 CDS YP_002386407.1 218553494 7127910 1011077..1012360 1 NC_011741.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1012360 aroA 7127910 aroA Escherichia coli IAI1 3-phosphoshikimate 1-carboxyvinyltransferase YP_002386407.1 1011077 D 585034 CDS YP_002386408.1 218553495 7125802 1012529..1013293 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative lipoprotein with metallohydrolase domain 1013293 ycaL 7125802 ycaL Escherichia coli IAI1 putative lipoprotein with metallohydrolase domain YP_002386408.1 1012529 D 585034 CDS YP_002386409.1 218553496 7124730 complement(1013243..1013389) 1 NC_011741.1 hypothetical protein 1013389 7124730 ECIAI1_0950 Escherichia coli IAI1 hypothetical protein YP_002386409.1 1013243 R 585034 CDS YP_002386410.1 218553497 7128632 1013466..1014149 1 NC_011741.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1014149 cmk 7128632 cmk Escherichia coli IAI1 cytidylate kinase YP_002386410.1 1013466 D 585034 CDS YP_002386411.1 218553498 7126338 1014260..1015933 1 NC_011741.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1015933 rpsA 7126338 rpsA Escherichia coli IAI1 30S ribosomal protein S1 YP_002386411.1 1014260 D 585034 CDS YP_002386412.1 218553499 7128407 1016093..1016377 1 NC_011741.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 1016377 ihfB 7128407 ihfB Escherichia coli IAI1 integration host factor subunit beta YP_002386412.1 1016093 D 585034 CDS YP_002386413.1 218553500 7126048 1016584..1018848 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1018848 ycaI 7126048 ycaI Escherichia coli IAI1 hypothetical protein YP_002386413.1 1016584 D 585034 CDS YP_002386414.1 218553501 7124727 1018885..1020633 1 NC_011741.1 involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease 1020633 msbA 7124727 msbA Escherichia coli IAI1 lipid transporter ATP-binding/permease YP_002386414.1 1018885 D 585034 CDS YP_002386415.1 218553502 7124478 1020630..1021616 1 NC_011741.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 1021616 lpxK 7124478 lpxK Escherichia coli IAI1 tetraacyldisaccharide 4'-kinase YP_002386415.1 1020630 D 585034 CDS YP_002386416.1 218553503 7127627 1021653..1022885 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1022885 ycaQ 7127627 ycaQ Escherichia coli IAI1 hypothetical protein YP_002386416.1 1021653 D 585034 CDS YP_002386417.1 218553504 7124735 1022937..1023119 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1023119 ycaR 7124735 ycaR Escherichia coli IAI1 hypothetical protein YP_002386417.1 1022937 D 585034 CDS YP_002386418.1 218553505 7124736 1023116..1023862 1 NC_011741.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 1023862 kdsB 7124736 kdsB Escherichia coli IAI1 3-deoxy-manno-octulosonate cytidylyltransferase YP_002386418.1 1023116 D 585034 CDS YP_002386419.1 218553506 7126379 1024016..1024909 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1024909 ycbJ 7126379 ycbJ Escherichia coli IAI1 hypothetical protein YP_002386419.1 1024016 D 585034 CDS YP_002386420.1 218553507 7124741 complement(1024886..1025665) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1025665 ycbC 7124741 ycbC Escherichia coli IAI1 hypothetical protein YP_002386420.1 1024886 R 585034 CDS YP_002386421.1 218553508 7124738 1025801..1026586 1 NC_011741.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; putative metallothionein SmtA 1026586 smtA 7124738 smtA Escherichia coli IAI1 putative metallothionein SmtA YP_002386421.1 1025801 D 585034 CDS YP_002386422.1 218553509 7127940 1026583..1027905 1 NC_011741.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 1027905 mukF 7127940 mukF Escherichia coli IAI1 condesin subunit F YP_002386422.1 1026583 D 585034 CDS YP_002386423.1 218553510 7124491 1027913..1028590 1 NC_011741.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 1028590 mukE 7124491 mukE Escherichia coli IAI1 condesin subunit E YP_002386423.1 1027913 D 585034 CDS YP_002386424.1 218553511 7124490 1028590..1033050 1 NC_011741.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 1033050 mukB 7124490 mukB Escherichia coli IAI1 cell division protein MukB YP_002386424.1 1028590 D 585034 CDS YP_002386425.1 218553512 7124489 1033311..1035158 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 1035158 ycbB 7124489 ycbB Escherichia coli IAI1 hypothetical protein YP_002386425.1 1033311 D 585034 CDS YP_002386426.1 218553513 7124737 1035339..1035887 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1035887 ycbK 7124737 ycbK Escherichia coli IAI1 hypothetical protein YP_002386426.1 1035339 D 585034 CDS YP_002386427.1 218553514 7124742 1035914..1036561 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14529289; Product type pe : putative enzyme; putative metal-binding hydrolase 1036561 ycbL 7124742 ycbL Escherichia coli IAI1 putative metal-binding hydrolase YP_002386427.1 1035914 D 585034 CDS YP_002386428.1 218553515 7124743 complement(1036783..1037973) 1 NC_011741.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 1037973 aspC 7124743 aspC Escherichia coli IAI1 aromatic amino acid aminotransferase YP_002386428.1 1036783 R 585034 CDS YP_002386429.1 218553516 7126266 complement(1038158..1039246) 1 NC_011741.1 outer membrane porin F; 1a; Ia; b; outer membrane protein F 1039246 ompF 7126266 ompF Escherichia coli IAI1 outer membrane protein F YP_002386429.1 1038158 R 585034 CDS YP_002386430.1 218553517 7125980 complement(1039848..1041248) 1 NC_011741.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 1041248 asnC 7125980 asnC Escherichia coli IAI1 asparaginyl-tRNA synthetase YP_002386430.1 1039848 R 585034 CDS YP_002386431.1 218553518 7126264 complement(1041417..1042619) 1 NC_011741.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1042619 pncB 7126264 pncB Escherichia coli IAI1 nicotinate phosphoribosyltransferase YP_002386431.1 1041417 R 585034 CDS YP_002386432.1 218553519 7126106 1042885..1045497 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101837, 86164315, 87163509, 2436977, 3018440; Product type e : enzyme; aminopeptidase N 1045497 pepN 7126106 pepN Escherichia coli IAI1 aminopeptidase N YP_002386432.1 1042885 D 585034 CDS YP_002386433.1 218553520 7124173 complement(1045704..1046471) 1 NC_011741.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease; aliphatic sulfonates transport ATP-binding subunit 1046471 ssuB 7124173 ssuB Escherichia coli IAI1 aliphatic sulfonates transport ATP-binding subunit YP_002386433.1 1045704 R 585034 CDS YP_002386434.1 218553521 7126182 complement(1046468..1047259) 1 NC_011741.1 part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter permease subunit 1047259 ssuC 7126182 ssuC Escherichia coli IAI1 alkanesulfonate transporter permease subunit YP_002386434.1 1046468 R 585034 CDS YP_002386435.1 218553522 7126183 complement(1047270..1048415) 1 NC_011741.1 catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase 1048415 ssuD 7126183 ssuD Escherichia coli IAI1 alkanesulfonate monooxygenase YP_002386435.1 1047270 R 585034 CDS YP_002386436.1 218553523 7126184 complement(1048412..1049371) 1 NC_011741.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit 1049371 ssuA 7126184 ssuA Escherichia coli IAI1 alkanesulfonate transporter substrate-binding subunit YP_002386436.1 1048412 R 585034 CDS YP_002386437.1 218553524 7126181 complement(1049364..1049939) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20245523, 99410391, 99436146, 8774726; Product type e : enzyme; NAD(P)H-dependent FMN reductase 1049939 ssuE 7126181 ssuE Escherichia coli IAI1 NAD(P)H-dependent FMN reductase YP_002386437.1 1049364 R 585034 CDS YP_002386438.1 218553525 7126185 1050286..1050837 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type ps : putative structure; putative fimbrial-like adhesin protein 1050837 ycbQ 7126185 ycbQ Escherichia coli IAI1 putative fimbrial-like adhesin protein YP_002386438.1 1050286 D 585034 CDS YP_002386439.1 218553526 7124744 1050920..1051621 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative periplasmic pilin chaperone 1051621 ycbR 7124744 ycbR Escherichia coli IAI1 putative periplasmic pilin chaperone YP_002386439.1 1050920 D 585034 CDS YP_002386440.1 218553527 7124745 1051646..1054246 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative outer membrane export usher protein 1054246 ycbS 7124745 ycbS Escherichia coli IAI1 putative outer membrane export usher protein YP_002386440.1 1051646 D 585034 CDS YP_002386441.1 218553528 7124746 1054237..1055307 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7721701; Product type ps : putative structure; putative fimbrial-like adhesin protein 1055307 ycbT 7124746 ycbT Escherichia coli IAI1 putative fimbrial-like adhesin protein YP_002386441.1 1054237 D 585034 CDS YP_002386442.1 218553529 7124747 1055319..1055861 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein 1055861 ycbU 7124747 ycbU Escherichia coli IAI1 putative fimbrial-like adhesin protein YP_002386442.1 1055319 D 585034 CDS YP_002386443.1 218553530 7124748 1055869..1056384 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative exported fimbrial-like adhesin protein 1056384 ycbV 7124748 ycbV Escherichia coli IAI1 putative exported fimbrial-like adhesin protein YP_002386443.1 1055869 D 585034 CDS YP_002386444.1 218553531 7124749 1056377..1057087 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putativi pili assembly chaperone 1057087 ycbF 7124749 ycbF Escherichia coli IAI1 putativi pili assembly chaperone YP_002386444.1 1056377 D 585034 CDS YP_002386445.1 218553532 7124739 1057198..1058208 1 NC_011741.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1058208 pyrD 7124739 pyrD Escherichia coli IAI1 dihydroorotate dehydrogenase 2 YP_002386445.1 1057198 D 585034 CDS YP_002386446.1 218553533 7126571 1058382..1058924 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1058924 ycbW 7126571 ycbW Escherichia coli IAI1 hypothetical protein YP_002386446.1 1058382 D 585034 CDS YP_002386447.1 218553534 7124750 complement(1058921..1060030) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1327782; Product type pe : putative enzyme; putative 2Fe-2S cluster-containing protein 1060030 ycbX 7124750 ycbX Escherichia coli IAI1 putative 2Fe-2S cluster-containing protein YP_002386447.1 1058921 R 585034 CDS YP_002386448.1 218553535 7124751 1060274..1062382 1 NC_011741.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 1062382 rlmL 7124751 rlmL Escherichia coli IAI1 23S rRNA m(2)G2445 methyltransferase YP_002386448.1 1060274 D 585034 CDS YP_002386449.1 218553536 7124752 1062394..1064301 1 NC_011741.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 1064301 uup 7124752 uup Escherichia coli IAI1 ABC transporter ATPase YP_002386449.1 1062394 D 585034 CDS YP_002386450.1 218553537 7125554 1064431..1065684 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95270582; Product type cp : cell process; paraquat-inducible membrane protein A 1065684 pqiA 7125554 pqiA Escherichia coli IAI1 paraquat-inducible membrane protein A YP_002386450.1 1064431 D 585034 CDS YP_002386451.1 218553538 7126140 1065689..1067329 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95270582; Product type cp : cell process; paraquat-inducible protein B 1067329 pqiB 7126140 pqiB Escherichia coli IAI1 paraquat-inducible protein B YP_002386451.1 1065689 D 585034 CDS YP_002386452.1 218553539 7126141 1067341..1067889 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1067889 ymbA 7126141 ymbA Escherichia coli IAI1 hypothetical protein YP_002386452.1 1067341 D 585034 CDS YP_002386453.1 218553540 7126671 1068145..1068312 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1101029, 90207255, 2832401, 8440252; Product type f : factor; ribosome modulation factor 1068312 rmf 7126671 rmf Escherichia coli IAI1 ribosome modulation factor YP_002386453.1 1068145 D 585034 CDS YP_002386454.1 218553541 7125013 complement(1068382..1068900) 1 NC_011741.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-(acyl carrier protein) dehydratase 1068900 fabA 7125013 fabA Escherichia coli IAI1 3-hydroxydecanoyl-(acyl carrier protein) dehydratase YP_002386454.1 1068382 R 585034 CDS YP_002386455.1 218553542 7127052 complement(1068969..1070729) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-dependent protease 1070729 ycbZ 7127052 ycbZ Escherichia coli IAI1 putative ATP-dependent protease YP_002386455.1 1068969 R 585034 CDS YP_002386456.1 218553543 7124753 1070915..1071367 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1071367 ycbG 7124753 ycbG Escherichia coli IAI1 hypothetical protein YP_002386456.1 1070915 D 585034 CDS YP_002386457.1 218553544 7124740 complement(1071442..1072566) 1 NC_011741.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein A 1072566 ompA 7124740 ompA Escherichia coli IAI1 outer membrane protein A YP_002386457.1 1071442 R 585034 CDS YP_002386458.1 218553545 7126078 complement(1072851..1073360) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10368140, 91072263, 93163041, 98348458, 3297925, 6253901, 6306396; Product type cp : cell process; SOS cell division inhibitor 1073360 sulA 7126078 sulA Escherichia coli IAI1 SOS cell division inhibitor YP_002386458.1 1072851 R 585034 CDS YP_002386459.1 218553546 7126201 1073579..1074208 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1074208 yccR 7126201 yccR Escherichia coli IAI1 hypothetical protein YP_002386459.1 1073579 D 585034 CDS YP_002386460.1 218553547 7124761 complement(1074171..1076324) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1076324 yccS 7124761 yccS Escherichia coli IAI1 hypothetical protein YP_002386460.1 1074171 R 585034 CDS YP_002386461.1 218553548 7124762 complement(1076343..1076789) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1076789 yccF 7124762 yccF Escherichia coli IAI1 hypothetical protein YP_002386461.1 1076343 R 585034 CDS YP_002386462.1 218553549 7124758 1076912..1078966 1 NC_011741.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 1078966 helD 7124758 helD Escherichia coli IAI1 DNA helicase IV YP_002386462.1 1076912 D 585034 CDS YP_002386463.1 218553550 7128504 complement(1078998..1079456) 1 NC_011741.1 catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 1079456 mgsA 7128504 mgsA Escherichia coli IAI1 methylglyoxal synthase YP_002386463.1 1078998 R 585034 CDS YP_002386464.1 218553551 7124260 complement(1079552..1080214) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1080214 yccT 7124260 yccT Escherichia coli IAI1 hypothetical protein YP_002386464.1 1079552 R 585034 CDS YP_002386465.1 218553552 7124763 1080387..1080800 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative CoA-binding protein 1080800 yccU 7124763 yccU Escherichia coli IAI1 putative CoA-binding protein YP_002386465.1 1080387 D 585034 CDS YP_002386466.1 218553553 7124764 complement(1080845..1081162) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12700277, 15569148; Product type f : factor; heat shock protein HspQ 1081162 yccV 7124764 yccV Escherichia coli IAI1 heat shock protein HspQ YP_002386466.1 1080845 R 585034 CDS YP_002386467.1 218553554 7124765 complement(1081220..1082323) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative AdoMet-dependent methyltransferase, UPF0064 family 1082323 yccW 7124765 yccW Escherichia coli IAI1 putative AdoMet-dependent methyltransferase, UPF0064 family YP_002386467.1 1081220 R 585034 CDS YP_002386468.1 218553555 7124766 1082292..1082783 1 NC_011741.1 catalyzes the hydrolysis of acylphosphate; acylphosphatase 1082783 yccX 7124766 yccX Escherichia coli IAI1 acylphosphatase YP_002386468.1 1082292 D 585034 CDS YP_002386469.1 218553556 7124767 complement(1082780..1083109) 1 NC_011741.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE 1083109 tusE 7124767 tusE Escherichia coli IAI1 sulfur transfer protein TusE YP_002386469.1 1082780 R 585034 CDS YP_002386470.1 218553557 7127523 complement(1083200..1083859) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6376117; Product type m : membrane component; hypothetical protein 1083859 yccA 7127523 yccA Escherichia coli IAI1 hypothetical protein YP_002386470.1 1083200 R 585034 CDS YP_002386471.1 218553558 7124754 complement(1084061..1084237) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 1084237 7124754 ECIAI1_1012 Escherichia coli IAI1 hypothetical protein YP_002386471.1 1084061 R 585034 CDS YP_002386472.1 218553559 7128058 1084580..1085698 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86192450, 90202716, 92215587; Product type e : enzyme; hydrogenase 1 small subunit 1085698 hyaA 7128058 hyaA Escherichia coli IAI1 hydrogenase 1 small subunit YP_002386472.1 1084580 D 585034 CDS YP_002386473.1 218553560 7125326 1085695..1087488 1 NC_011741.1 involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit 1087488 hyaB 7125326 hyaB Escherichia coli IAI1 hydrogenase 1 large subunit YP_002386473.1 1085695 D 585034 CDS YP_002386474.1 218553561 7125327 1087507..1088214 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202716, 91310595, 92215587; Product type c : carrier; hydrogenase 1 b-type cytochrome subunit 1088214 hyaC 7125327 hyaC Escherichia coli IAI1 hydrogenase 1 b-type cytochrome subunit YP_002386474.1 1087507 D 585034 CDS YP_002386475.1 218553562 7125328 1088211..1088798 1 NC_011741.1 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 1088798 hyaD 7125328 hyaD Escherichia coli IAI1 hydrogenase 1 maturation protease YP_002386475.1 1088211 D 585034 CDS YP_002386476.1 218553563 7125329 1088795..1089193 1 NC_011741.1 involved in processing hydrogenase proteins HyaA and HyaB; hydrogenase-1 operon protein HyaE 1089193 hyaE 7125329 hyaE Escherichia coli IAI1 hydrogenase-1 operon protein HyaE YP_002386476.1 1088795 D 585034 CDS YP_002386477.1 218553564 7125330 1089190..1090047 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202716, 91310595, 92215587; Product type f : factor; hydrogenase-1 nickel incorporation protein 1090047 hyaF 7125330 hyaF Escherichia coli IAI1 hydrogenase-1 nickel incorporation protein YP_002386477.1 1089190 D 585034 CDS YP_002386478.1 218553565 7125331 1090181..1091725 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92049231, 96198179; Product type c : carrier; cytochrome bd-II oxidase subunit I 1091725 appC 7125331 appC Escherichia coli IAI1 cytochrome bd-II oxidase subunit I YP_002386478.1 1090181 D 585034 CDS YP_002386479.1 218553566 7125772 1091737..1092873 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92049231, 96198179; Product type c : carrier; cytochrome bd-II oxidase subunit II 1092873 appB 7125772 appB Escherichia coli IAI1 cytochrome bd-II oxidase subunit II YP_002386479.1 1091737 D 585034 CDS YP_002386480.1 218553567 7125771 1093058..1094356 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20122624, 92049231, 93054596, 10696472, 2168385, 3038201, 8387749; Product type e : enzyme; phosphoanhydride phosphorylase 1094356 appA 7125771 appA Escherichia coli IAI1 phosphoanhydride phosphorylase YP_002386480.1 1093058 D 585034 CDS YP_002386481.1 218553568 7125770 complement(1094471..1096651) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10369665, 11090276, 2168385, 7984428; Product type e : enzyme; cryptic autophosphorylating protein tyrosine kinase Etk 1096651 yccC 7125770 yccC Escherichia coli IAI1 cryptic autophosphorylating protein tyrosine kinase Etk YP_002386481.1 1094471 R 585034 CDS YP_002386482.1 218553569 7124755 complement(1096671..1097117) 1 NC_011741.1 Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk; phosphotyrosine-protein phosphatase 1097117 etp 7124755 etp Escherichia coli IAI1 phosphotyrosine-protein phosphatase YP_002386482.1 1096671 R 585034 CDS YP_002386483.1 218553570 7125092 complement(1097105..1098244) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8759852; Product type pt : putative transporter; putative exopolysaccharide export protein 1098244 yccZ 7125092 yccZ Escherichia coli IAI1 putative exopolysaccharide export protein YP_002386483.1 1097105 R 585034 CDS YP_002386484.1 218553571 7124768 complement(1098290..1100386) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1100386 ymcA 7124768 ymcA Escherichia coli IAI1 hypothetical protein YP_002386484.1 1098290 R 585034 CDS YP_002386485.1 218553572 7126672 complement(1100386..1101132) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1101132 ymcB 7126672 ymcB Escherichia coli IAI1 hypothetical protein YP_002386485.1 1100386 R 585034 CDS YP_002386486.1 218553573 7126673 complement(1101129..1101773) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein 1101773 ymcC 7126673 ymcC Escherichia coli IAI1 putative outer membrane lipoprotein YP_002386486.1 1101129 R 585034 CDS YP_002386487.1 218553574 7126674 complement(1101880..1102185) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1102185 ymcD 7126674 ymcD Escherichia coli IAI1 hypothetical protein YP_002386487.1 1101880 R 585034 CDS YP_002386488.1 218553575 7126675 complement(1102627..1102839) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9484881, 9439003; Product type f : factor; stress protein, member of the CspA-family 1102839 cspH 7126675 cspH Escherichia coli IAI1 stress protein, member of the CspA-family YP_002386488.1 1102627 R 585034 CDS YP_002386489.1 218553576 7126850 1102741..1102884 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 1102884 7126850 ECIAI1_1030 Escherichia coli IAI1 hypothetical protein YP_002386489.1 1102741 D 585034 CDS YP_002386490.1 218553577 7128634 1103125..1103337 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9484881, 15466053, 8631696, 9439003; Product type r : regulator; cold shock protein CspG 1103337 cspG 7128634 cspG Escherichia coli IAI1 cold shock protein CspG YP_002386490.1 1103125 D 585034 CDS YP_002386491.1 218553578 7128610 1103276..1103536 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative cold-shock protein (fragment) 1103536 7128610 ECIAI1_1032 Escherichia coli IAI1 putative cold-shock protein (fragment) YP_002386491.1 1103276 D 585034 CDS YP_002386492.1 218553579 7128635 1103731..1103904 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15317805, 11544213; Product type pr : putative regulator; putative regulator of phosphatidylethanolamine synthesis 1103904 gnsA 7128635 gnsA Escherichia coli IAI1 putative regulator of phosphatidylethanolamine synthesis YP_002386492.1 1103731 D 585034 CDS YP_002386493.1 218553580 7128367 complement(1103953..1105026) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S membrane protein 1105026 yccM 7128367 yccM Escherichia coli IAI1 putative 4Fe-4S membrane protein YP_002386493.1 1103953 R 585034 CDS YP_002386494.1 218553581 7124760 complement(1104900..1105064) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 1105064 7124760 ECIAI1_1035 Escherichia coli IAI1 hypothetical protein YP_002386494.1 1104900 R 585034 CDS YP_002386495.1 218553582 7128636 complement(1105098..1107842) 1 NC_011741.1 Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide; hybrid sensory histidine kinase TorS 1107842 torS 7128636 torS Escherichia coli IAI1 hybrid sensory histidine kinase TorS YP_002386495.1 1105098 R 585034 CDS YP_002386496.1 218553583 7127470 1107925..1108953 1 NC_011741.1 periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 1108953 torT 7127470 torT Escherichia coli IAI1 TMAO reductase system periplasmic protein TorT YP_002386496.1 1107925 D 585034 CDS YP_002386497.1 218553584 7127471 complement(1108926..1109618) 1 NC_011741.1 response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR 1109618 torR 7127471 torR Escherichia coli IAI1 DNA-binding transcriptional regulator TorR YP_002386497.1 1108926 R 585034 CDS YP_002386498.1 218553585 7127469 1109748..1110920 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293785, 94314186, 99340208, 11056172, 11562502; Product type c : carrier; trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit 1110920 torC 7127469 torC Escherichia coli IAI1 trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit YP_002386498.1 1109748 D 585034 CDS YP_002386499.1 218553586 7127467 1110920..1113466 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88193091, 90089471, 94293785, 8302830, 8022286; Product type e : enzyme; trimethylamine N-oxide (TMAO) reductase I, catalytic subunit 1113466 torA 7127467 torA Escherichia coli IAI1 trimethylamine N-oxide (TMAO) reductase I, catalytic subunit YP_002386499.1 1110920 D 585034 CDS YP_002386500.1 218553587 7127466 1113463..1114062 1 NC_011741.1 TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; chaperone protein TorD 1114062 torD 7127466 torD Escherichia coli IAI1 chaperone protein TorD YP_002386500.1 1113463 D 585034 CDS YP_002386501.1 218553588 7127468 complement(1114155..1114460) 1 NC_011741.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM 1114460 cbpM 7127468 cbpM Escherichia coli IAI1 chaperone-modulator protein CbpM YP_002386501.1 1114155 R 585034 CDS YP_002386502.1 218553589 7124452 complement(1114460..1115380) 1 NC_011741.1 functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA 1115380 cbpA 7124452 cbpA Escherichia coli IAI1 curved DNA-binding protein CbpA YP_002386502.1 1114460 R 585034 CDS YP_002386503.1 218553590 7124757 1117190..1118431 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12455612, 90368616, 91297199, 2153660, 9298646; Product type e : enzyme; glucose-1-phosphatase/inositol phosphatase 1118431 agp 7124757 agp Escherichia coli IAI1 glucose-1-phosphatase/inositol phosphatase YP_002386503.1 1117190 D 585034 CDS YP_002386504.1 218553591 7125735 complement(1118469..1118696) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1118696 yccJ 7125735 yccJ Escherichia coli IAI1 hypothetical protein YP_002386504.1 1118469 R 585034 CDS YP_002386505.1 218553592 7124759 complement(1118717..1119313) 1 NC_011741.1 stationary phase protein that binds TrpR repressor; TrpR binding protein WrbA 1119313 wrbA 7124759 wrbA Escherichia coli IAI1 TrpR binding protein WrbA YP_002386505.1 1118717 R 585034 CDS YP_002386506.1 218553593 7126457 1119523..1119753 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 1119753 7126457 ECIAI1_1049 Escherichia coli IAI1 hypothetical protein YP_002386506.1 1119523 D 585034 CDS YP_002386507.1 218553594 7128637 1119686..1119859 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1119859 ymdF 7128637 ymdF Escherichia coli IAI1 hypothetical protein YP_002386507.1 1119686 D 585034 CDS YP_002386508.1 218553595 7126679 complement(1120117..1121445) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type t : transporter; pyrimidine transporter 1121445 rutG 7126679 rutG Escherichia coli IAI1 pyrimidine transporter YP_002386508.1 1120117 R 585034 CDS YP_002386509.1 218553596 7124642 complement(1121466..1121960) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542, 10633095; Product type e : enzyme; flavin:NADH oxidoreductase subunit of alternative pyrimidine degradation pathway 1121960 rutF 7124642 rutF Escherichia coli IAI1 flavin:NADH oxidoreductase subunit of alternative pyrimidine degradation pathway YP_002386509.1 1121466 R 585034 CDS YP_002386510.1 218553597 7124641 complement(1121971..1122561) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; hypothetical protein 1122561 rutE 7124641 rutE Escherichia coli IAI1 hypothetical protein YP_002386510.1 1121971 R 585034 CDS YP_002386511.1 218553598 7124640 complement(1122571..1123371) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; enzyme of the alternative pyrimidine degradation pathway 1123371 rutD 7124640 rutD Escherichia coli IAI1 enzyme of the alternative pyrimidine degradation pathway YP_002386511.1 1122571 R 585034 CDS YP_002386512.1 218553599 7124639 complement(1123379..1123765) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; enzyme of the alternative pyrimidine degradation pathway 1123765 rutC 7124639 rutC Escherichia coli IAI1 enzyme of the alternative pyrimidine degradation pathway YP_002386512.1 1123379 R 585034 CDS YP_002386513.1 218553600 7124638 complement(1123777..1124469) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; enzyme of the alternative pyrimidine degradation pathway 1124469 rutB 7124638 rutB Escherichia coli IAI1 enzyme of the alternative pyrimidine degradation pathway YP_002386513.1 1123777 R 585034 CDS YP_002386514.1 218553601 7124637 complement(1124469..1125617) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; monooxygenase of the alternative pyrimidine degradation pathway 1125617 rutA 7124637 rutA Escherichia coli IAI1 monooxygenase of the alternative pyrimidine degradation pathway YP_002386514.1 1124469 R 585034 CDS YP_002386515.1 218553602 7124636 1125848..1126486 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type r : regulator; DNA-binding transcriptional regulator of the alternative pyrimidine degradation pathway 1126486 rutR 7124636 rutR Escherichia coli IAI1 DNA-binding transcriptional regulator of the alternative pyrimidine degradation pathway YP_002386515.1 1125848 D 585034 CDS YP_002386516.1 218553603 7124643 complement(1126526..1130488) 1 NC_011741.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein; trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 1130488 putA 7124643 putA Escherichia coli IAI1 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase YP_002386516.1 1126526 R 585034 CDS YP_002386517.1 218553604 7126558 complement(1130640..1130831) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1130831 7126558 ECIAI1_1060 Escherichia coli IAI1 hypothetical protein YP_002386517.1 1130640 R 585034 CDS YP_002386518.1 218553605 7128638 1130911..1132419 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12923181, 88213396, 91227628, 93132799, 98359785, 1400239, 1567896, 3053649, 3053687, 3302614, 3325781, 8119910; Product type t : transporter; proline:sodium symporter 1132419 putP 7128638 putP Escherichia coli IAI1 proline:sodium symporter YP_002386518.1 1130911 D 585034 CDS YP_002386519.1 218553606 7126559 1132952..1133791 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter; ferrous iron permease 1133791 efeU 7126559 efeU Escherichia coli IAI1 ferrous iron permease YP_002386519.1 1132952 D 585034 CDS YP_002386520.1 218553607 7125052 1133849..1134976 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17627767, 10493123; Product type t : transporter; hypothetical protein 1134976 efeO 7125052 efeO Escherichia coli IAI1 hypothetical protein YP_002386520.1 1133849 D 585034 CDS YP_002386521.1 218553608 7125051 1134982..1136253 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17627767, 16551627, 15375152; Product type t : transporter; iron transport heme-binding periplasmic protein 1136253 efeB 7125051 efeB Escherichia coli IAI1 iron transport heme-binding periplasmic protein YP_002386521.1 1134982 D 585034 CDS YP_002386522.1 218553609 7125050 1136597..1137661 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8444794, 2160940; Product type pe : putative enzyme; hypothetical protein 1137661 phoH 7125050 phoH Escherichia coli IAI1 hypothetical protein YP_002386522.1 1136597 D 585034 CDS YP_002386523.1 218553610 7124217 1138245..1138931 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1138931 7124217 ECIAI1_1066 Escherichia coli IAI1 hypothetical protein YP_002386523.1 1138245 D 585034 CDS YP_002386524.1 218553611 7128057 1139706..1140644 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11237876, 10493123; Product type e : enzyme; 2-ketoacid reductase 1140644 ycdW 7128057 ycdW Escherichia coli IAI1 2-ketoacid reductase YP_002386524.1 1139706 D 585034 CDS YP_002386525.1 218553612 7124769 1140699..1141436 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12661000; Product type pe : putative enzyme; putative hydrolase 1141436 ycdX 7124769 ycdX Escherichia coli IAI1 putative hydrolase YP_002386525.1 1140699 D 585034 CDS YP_002386526.1 218553613 7124770 1141460..1142014 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1142014 ycdY 7124770 ycdY Escherichia coli IAI1 hypothetical protein YP_002386526.1 1141460 D 585034 CDS YP_002386527.1 218553614 7124771 1142116..1142607 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1142607 ycdZ 7124771 ycdZ Escherichia coli IAI1 hypothetical protein YP_002386527.1 1142116 D 585034 CDS YP_002386528.1 218553615 7124772 complement(1142671..1143504) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8817489; Product type lp : lipoprotein; putative outer membrane lipoprotein involved in curli production assembly/transport 1143504 csgG 7124772 csgG Escherichia coli IAI1 putative outer membrane lipoprotein involved in curli production assembly/transport YP_002386528.1 1142671 R 585034 CDS YP_002386529.1 218553616 7125928 complement(1143531..1143947) 1 NC_011741.1 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF 1143947 csgF 7125928 csgF Escherichia coli IAI1 curli assembly protein CsgF YP_002386529.1 1143531 R 585034 CDS YP_002386530.1 218553617 7125927 complement(1143972..1144361) 1 NC_011741.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE 1144361 csgE 7125927 csgE Escherichia coli IAI1 curli assembly protein CsgE YP_002386530.1 1143972 R 585034 CDS YP_002386531.1 218553618 7125926 complement(1144366..1145016) 1 NC_011741.1 activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD 1145016 csgD 7125926 csgD Escherichia coli IAI1 DNA-binding transcriptional regulator CsgD YP_002386531.1 1144366 R 585034 CDS YP_002386532.1 218553619 7125925 1145770..1146225 1 NC_011741.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit 1146225 csgB 7125925 csgB Escherichia coli IAI1 curlin minor subunit YP_002386532.1 1145770 D 585034 CDS YP_002386533.1 218553620 7125923 1146266..1146721 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89201357, 93023873, 1677357, 8459772, 8817489, 1357528; Product type s : structure; cryptic curlin major subunit 1146721 csgA 7125923 csgA Escherichia coli IAI1 cryptic curlin major subunit YP_002386533.1 1146266 D 585034 CDS YP_002386534.1 218553621 7125922 1146780..1147112 1 NC_011741.1 involved in autoagglutination of curliated cells; not involved in production of curli fibers; putative autoagglutination protein 1147112 csgC 7125922 csgC Escherichia coli IAI1 putative autoagglutination protein YP_002386534.1 1146780 D 585034 CDS YP_002386535.1 218553622 7125924 1147233..1147544 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1147544 ymdA 7125924 ymdA Escherichia coli IAI1 hypothetical protein YP_002386535.1 1147233 D 585034 CDS YP_002386536.1 218553623 7126676 1147639..1148172 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1148172 ymdB 7126676 ymdB Escherichia coli IAI1 hypothetical protein YP_002386536.1 1147639 D 585034 CDS YP_002386537.1 218553624 7126677 1148174..1149595 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 1149595 ymdC 7126677 ymdC Escherichia coli IAI1 putative hydrolase YP_002386537.1 1148174 D 585034 CDS YP_002386538.1 218553625 7126678 complement(1149603..1150760) 1 NC_011741.1 required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein 1150760 mdoC 7126678 mdoC Escherichia coli IAI1 glucans biosynthesis protein YP_002386538.1 1149603 R 585034 CDS YP_002386539.1 218553626 7127684 complement(1150805..1150948) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 1150948 7127684 ECIAI1_1082 Escherichia coli IAI1 hypothetical protein YP_002386539.1 1150805 R 585034 CDS YP_002386540.1 218553627 7128640 complement(1150952..1151110) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 1151110 7128640 ECIAI1_1083 Escherichia coli IAI1 hypothetical protein YP_002386540.1 1150952 R 585034 CDS YP_002386541.1 218553628 7128641 1151154..1152689 1 NC_011741.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 1152689 mdoG 7128641 mdoG Escherichia coli IAI1 glucan biosynthesis protein G YP_002386541.1 1151154 D 585034 CDS YP_002386542.1 218553629 7127686 1152682..1155225 1 NC_011741.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 1155225 mdoH 7127686 mdoH Escherichia coli IAI1 glucosyltransferase MdoH YP_002386542.1 1152682 D 585034 CDS YP_002386543.1 218553630 7127687 1155398..1155625 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 1155625 yceK 7127687 yceK Escherichia coli IAI1 hypothetical protein YP_002386543.1 1155398 D 585034 CDS YP_002386544.1 218553631 7126687 complement(1155626..1156000) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 92165719; hypothetical protein 1156000 msyB 7126687 msyB Escherichia coli IAI1 hypothetical protein YP_002386544.1 1155626 R 585034 CDS YP_002386545.1 218553632 7124483 complement(1156083..1157309) 1 NC_011741.1 Confers resistance to fosfomycin and deoxycholate; drug efflux system protein MdtG 1157309 mdtG 7124483 mdtG Escherichia coli IAI1 drug efflux system protein MdtG YP_002386545.1 1156083 R 585034 CDS YP_002386546.1 218553633 7127694 complement(1157481..1158401) 1 NC_011741.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 1158401 lpxL 7127694 lpxL Escherichia coli IAI1 lipid A biosynthesis lauroyl acyltransferase YP_002386546.1 1157481 R 585034 CDS YP_002386547.1 218553634 7127628 1158626..1159678 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1840644; hypothetical protein 1159678 yceA 7127628 yceA Escherichia coli IAI1 hypothetical protein YP_002386547.1 1158626 D 585034 CDS YP_002386548.1 218553635 7124773 complement(1159720..1160295) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15741337, 11298273, 1840644, 9298646; Product type c : carrier; hypothetical protein 1160295 yceI 7124773 yceI Escherichia coli IAI1 hypothetical protein YP_002386548.1 1159720 R 585034 CDS YP_002386549.1 218553636 7124779 complement(1160299..1160865) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative cytochrome b561 1160865 yceJ 7124779 yceJ Escherichia coli IAI1 putative cytochrome b561 YP_002386549.1 1160299 R 585034 CDS YP_002386550.1 218553637 7124780 complement(1161126..1161266) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1161266 yceO 7124780 yceO Escherichia coli IAI1 hypothetical protein YP_002386550.1 1161126 R 585034 CDS YP_002386551.1 218553638 7126177 complement(1161287..1162405) 1 NC_011741.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase 1162405 solA 7126177 solA Escherichia coli IAI1 N-methyltryptophan oxidase YP_002386551.1 1161287 R 585034 CDS YP_002386552.1 218553639 7127948 complement(1162520..1162774) 1 NC_011741.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS 1162774 bssS 7127948 bssS Escherichia coli IAI1 biofilm formation regulatory protein BssS YP_002386552.1 1162520 R 585034 CDS YP_002386553.2 229598864 7124422 complement(1163064..1163309) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11230150, 11152126; Product type f : factor; DNA damage-inducible protein I 1163309 dinI 7124422 dinI Escherichia coli IAI1 DNA damage-inducible protein I YP_002386553.2 1163064 R 585034 CDS YP_002386554.1 218553641 7124590 complement(1163383..1164429) 1 NC_011741.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1164429 pyrC 7124590 pyrC Escherichia coli IAI1 dihydroorotase YP_002386554.1 1163383 R 585034 CDS YP_002386555.1 218553642 7126570 complement(1164535..1165095) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 1165095 yceB 7126570 yceB Escherichia coli IAI1 hypothetical protein YP_002386555.1 1164535 R 585034 CDS YP_002386556.1 218553643 7124774 complement(1165229..1165876) 1 NC_011741.1 cofactor involved in the reduction of disulfides; glutaredoxin 2 1165876 grxB 7124774 grxB Escherichia coli IAI1 glutaredoxin 2 YP_002386556.1 1165229 R 585034 CDS YP_002386557.1 218553644 7128469 complement(1165940..1167148) 1 NC_011741.1 Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH 1167148 mdtH 7128469 mdtH Escherichia coli IAI1 multidrug resistance protein MdtH YP_002386557.1 1165940 R 585034 CDS YP_002386558.1 218553645 7124146 1167384..1167968 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88121676, 90136529, 1356970; Product type e : enzyme; ribosomal-protein-S5-alanine N-acetyltransferase 1167968 rimJ 7124146 rimJ Escherichia coli IAI1 ribosomal-protein-S5-alanine N-acetyltransferase YP_002386558.1 1167384 D 585034 CDS YP_002386559.1 218553646 7125002 1167979..1168626 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1356970, 2828880; hypothetical protein 1168626 yceH 7125002 yceH Escherichia coli IAI1 hypothetical protein YP_002386559.1 1167979 D 585034 CDS YP_002386560.1 218553647 7124778 1168628..1169551 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1169551 mviM 7124778 mviM Escherichia coli IAI1 putative oxidoreductase YP_002386560.1 1168628 D 585034 CDS YP_002386561.1 218553648 7124508 1169661..1171196 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1171196 mviN 7124508 mviN Escherichia coli IAI1 hypothetical protein YP_002386561.1 1169661 D 585034 CDS YP_002386562.1 218553649 7124509 complement(1171236..1171652) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10320579; Product type f : factor; export chaperone for FlgK and FlgL 1171652 flgN 7124509 flgN Escherichia coli IAI1 export chaperone for FlgK and FlgL YP_002386562.1 1171236 R 585034 CDS YP_002386563.1 218553650 7127225 complement(1171657..1171950) 1 NC_011741.1 regulates the flagellar specific sigma28 transcription factor; anti-sigma28 factor FlgM 1171950 flgM 7127225 flgM Escherichia coli IAI1 anti-sigma28 factor FlgM YP_002386563.1 1171657 R 585034 CDS YP_002386564.1 218553651 7127224 complement(1172026..1172685) 1 NC_011741.1 required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA 1172685 flgA 7127224 flgA Escherichia coli IAI1 flagellar basal body P-ring biosynthesis protein FlgA YP_002386564.1 1172026 R 585034 CDS YP_002386565.1 218553652 7127211 1172840..1173256 1 NC_011741.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal body rod protein FlgB 1173256 flgB 7127211 flgB Escherichia coli IAI1 flagellar basal body rod protein FlgB YP_002386565.1 1172840 D 585034 CDS YP_002386566.1 218553653 7127212 1173260..1173664 1 NC_011741.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 1173664 flgC 7127212 flgC Escherichia coli IAI1 flagellar basal body rod protein FlgC YP_002386566.1 1173260 D 585034 CDS YP_002386567.1 218553654 7127213 1173676..1174371 1 NC_011741.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein 1174371 flgD 7127213 flgD Escherichia coli IAI1 flagellar basal body rod modification protein YP_002386567.1 1173676 D 585034 CDS YP_002386568.1 218553655 7127216 1175620..1176375 1 NC_011741.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF 1176375 flgF 7127216 flgF Escherichia coli IAI1 flagellar basal body rod protein FlgF YP_002386568.1 1175620 D 585034 CDS YP_002386569.1 218553656 7127217 1176513..1177295 1 NC_011741.1 makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 1177295 flgG 7127217 flgG Escherichia coli IAI1 flagellar basal body rod protein FlgG YP_002386569.1 1176513 D 585034 CDS YP_002386570.1 218553657 7127218 1177348..1178046 1 NC_011741.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 1178046 flgH 7127218 flgH Escherichia coli IAI1 flagellar basal body L-ring protein YP_002386570.1 1177348 D 585034 CDS YP_002386571.1 218553658 7127219 1178058..1179155 1 NC_011741.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring protein 1179155 flgI 7127219 flgI Escherichia coli IAI1 flagellar basal body P-ring protein YP_002386571.1 1178058 D 585034 CDS YP_002386572.1 218553659 7127220 1179155..1180096 1 NC_011741.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 1180096 flgJ 7127220 flgJ Escherichia coli IAI1 flagellar rod assembly protein/muramidase FlgJ YP_002386572.1 1179155 D 585034 CDS YP_002386573.1 218553660 7127221 1180162..1181805 1 NC_011741.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 1181805 flgK 7127221 flgK Escherichia coli IAI1 flagellar hook-associated protein FlgK YP_002386573.1 1180162 D 585034 CDS YP_002386574.1 218553661 7127222 1181817..1182770 1 NC_011741.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; flagellar hook-associated protein FlgL 1182770 flgL 7127222 flgL Escherichia coli IAI1 flagellar hook-associated protein FlgL YP_002386574.1 1181817 D 585034 CDS YP_002386575.1 218553662 7127223 complement(1182967..1186152) 1 NC_011741.1 bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E 1186152 rne 7127223 rne Escherichia coli IAI1 ribonuclease E YP_002386575.1 1182967 R 585034 CDS YP_002386576.1 218553663 7125490 1186725..1187684 1 NC_011741.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 1187684 rluC 7125490 rluC Escherichia coli IAI1 23S rRNA pseudouridylate synthase C YP_002386576.1 1186725 D 585034 CDS YP_002386577.1 218553664 7125011 complement(1187796..1188380) 1 NC_011741.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 1188380 yceF 7125011 yceF Escherichia coli IAI1 Maf-like protein YP_002386577.1 1187796 R 585034 CDS YP_002386578.1 218553665 7127968 1188579..1189100 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 90008815, 1447160; hypothetical protein 1189100 yceD 7127968 yceD Escherichia coli IAI1 hypothetical protein YP_002386578.1 1188579 D 585034 CDS YP_002386579.1 218553666 7124775 1189152..1189325 1 NC_011741.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1189325 rpmF 7124775 rpmF Escherichia coli IAI1 50S ribosomal protein L32 YP_002386579.1 1189152 D 585034 CDS YP_002386580.1 218553667 7128392 1189406..1190476 1 NC_011741.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX 1190476 plsX 7128392 plsX Escherichia coli IAI1 putative glycerol-3-phosphate acyltransferase PlsX YP_002386580.1 1189406 D 585034 CDS YP_002386581.1 218553668 7126101 1190544..1191497 1 NC_011741.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III 1191497 fabH 7126101 fabH Escherichia coli IAI1 3-oxoacyl-(acyl carrier protein) synthase III YP_002386581.1 1190544 D 585034 CDS YP_002386582.1 218553669 7127057 1191513..1192442 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92052166, 92183950, 92210530, 92234941, 7700236, 7768883, 9298646; Product type e : enzyme; malonyl-CoA-[acyl-carrier-protein] transacylase 1192442 fabD 7127057 fabD Escherichia coli IAI1 malonyl-CoA-[acyl-carrier-protein] transacylase YP_002386582.1 1191513 D 585034 CDS YP_002386583.1 218553670 7127054 1192455..1193189 1 NC_011741.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 1193189 fabG 7127054 fabG Escherichia coli IAI1 3-ketoacyl-(acyl-carrier-protein) reductase YP_002386583.1 1192455 D 585034 CDS YP_002386584.1 218553671 7127056 1193400..1193636 1 NC_011741.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1193636 acpP 7127056 acpP Escherichia coli IAI1 acyl carrier protein YP_002386584.1 1193400 D 585034 CDS YP_002386585.1 218553672 7125703 1193724..1194965 1 NC_011741.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 1194965 fabF 7125703 fabF Escherichia coli IAI1 3-oxoacyl-(acyl carrier protein) synthase II YP_002386585.1 1193724 D 585034 CDS YP_002386586.1 218553673 7127055 1195085..1195894 1 NC_011741.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 1195894 pabC 7127055 pabC Escherichia coli IAI1 4-amino-4-deoxychorismate lyase YP_002386586.1 1195085 D 585034 CDS YP_002386587.1 218553674 7124148 1195897..1196919 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 1196919 yceG 7124148 yceG Escherichia coli IAI1 hypothetical protein YP_002386587.1 1195897 D 585034 CDS YP_002386588.1 218553675 7124777 1196909..1197550 1 NC_011741.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1197550 tmk 7124777 tmk Escherichia coli IAI1 thymidylate kinase YP_002386588.1 1196909 D 585034 CDS YP_002386589.1 218553676 7127454 1197547..1198551 1 NC_011741.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1198551 holB 7127454 holB Escherichia coli IAI1 DNA polymerase III subunit delta' YP_002386589.1 1197547 D 585034 CDS YP_002386590.1 218553677 7125292 1198562..1199359 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8505303, 8509334, 10747959; Product type pe : putative enzyme; putative metallodependent hydrolase 1199359 ycfH 7125292 ycfH Escherichia coli IAI1 putative metallodependent hydrolase YP_002386590.1 1198562 D 585034 CDS YP_002386591.1 218553678 7127777 1199654..1201087 1 NC_011741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunits IIBC 1201087 ptsG 7127777 ptsG Escherichia coli IAI1 PTS system glucose-specific transporter subunits IIBC YP_002386591.1 1199654 D 585034 CDS YP_002386592.1 218553679 7126539 complement(1201147..1203336) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90286919, 3032906, 10529396; Product type t : transporter; ferric-rhodotorulic acid outer membrane transporter 1203336 fhuE 7126539 fhuE Escherichia coli IAI1 ferric-rhodotorulic acid outer membrane transporter YP_002386592.1 1201147 R 585034 CDS YP_002386593.1 218553680 7127102 1203670..1204029 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15703176, 10493123, 2162465; Product type e : enzyme; purine nucleoside phosphoramidase 1204029 hinT 7127102 hinT Escherichia coli IAI1 purine nucleoside phosphoramidase YP_002386593.1 1203670 D 585034 CDS YP_002386594.1 218553681 7128525 1204032..1204409 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1204409 ycfL 7128525 ycfL Escherichia coli IAI1 hypothetical protein YP_002386594.1 1204032 D 585034 CDS YP_002386595.1 218553682 7127779 1204423..1205064 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein 1205064 ycfM 7127779 ycfM Escherichia coli IAI1 putative outer membrane lipoprotein YP_002386595.1 1204423 D 585034 CDS YP_002386596.1 218553683 7127780 1205045..1205869 1 NC_011741.1 catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 1205869 thiK 7127780 thiK Escherichia coli IAI1 thiamine kinase YP_002386596.1 1205045 D 585034 CDS YP_002386597.1 218553684 7127781 1205880..1206905 1 NC_011741.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1206905 nagZ 7127781 nagZ Escherichia coli IAI1 beta-hexosaminidase YP_002386597.1 1205880 D 585034 CDS YP_002386598.1 218553685 7124522 1206928..1207470 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1207470 ycfP 7124522 ycfP Escherichia coli IAI1 hypothetical protein YP_002386598.1 1206928 D 585034 CDS YP_002386599.1 218553686 7127782 1207878..1209182 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14766919, 20130027, 81256452, 92296775, 94042945, 99441207, 6265208; Product type e : enzyme; respiratory NADH dehydrogenase 2/cupric reductase 1209182 ndh 7127782 ndh Escherichia coli IAI1 respiratory NADH dehydrogenase 2/cupric reductase YP_002386599.1 1207878 D 585034 CDS YP_002386600.1 218553687 7127863 1209392..1209931 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6265208, 7984428; hypothetical protein 1209931 ycfJ 7127863 ycfJ Escherichia coli IAI1 hypothetical protein YP_002386600.1 1209392 D 585034 CDS YP_002386601.1 218553688 7127778 complement(1209993..1210625) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1210625 ycfQ 7127778 ycfQ Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002386601.1 1209993 R 585034 CDS YP_002386602.1 218553689 7127783 1210866..1211123 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089; hypothetical protein 1211123 ycfR 7127783 ycfR Escherichia coli IAI1 hypothetical protein YP_002386602.1 1210866 D 585034 CDS YP_002386603.1 218553690 7127784 complement(1211206..1212168) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1212168 ycfS 7127784 ycfS Escherichia coli IAI1 hypothetical protein YP_002386603.1 1211206 R 585034 CDS YP_002386604.1 218553691 7127785 complement(1212312..1215758) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14602898, 90158497, 92107993, 8465200; Product type f : factor; transcription-repair coupling factor 1215758 mfd 7127785 mfd Escherichia coli IAI1 transcription-repair coupling factor YP_002386604.1 1212312 R 585034 CDS YP_002386605.1 218553692 7124256 complement(1215886..1216959) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1216959 ycfT 7124256 ycfT Escherichia coli IAI1 hypothetical protein YP_002386605.1 1215886 R 585034 CDS YP_002386606.1 218553693 7127786 1217221..1218420 1 NC_011741.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC 1218420 lolC 7127786 lolC Escherichia coli IAI1 outer membrane-specific lipoprotein transporter subunit LolC YP_002386606.1 1217221 D 585034 CDS YP_002386607.1 218553694 7126435 1218413..1219114 1 NC_011741.1 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding subunit 1219114 lolD 7126435 lolD Escherichia coli IAI1 lipoprotein transporter ATP-binding subunit YP_002386607.1 1218413 D 585034 CDS YP_002386608.1 218553695 7126436 1219114..1220358 1 NC_011741.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1220358 lolE 7126436 lolE Escherichia coli IAI1 outer membrane-specific lipoprotein transporter subunit LolE YP_002386608.1 1219114 D 585034 CDS YP_002386609.1 218553696 7126437 1220387..1221298 1 NC_011741.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 1221298 ycfX 7126437 ycfX Escherichia coli IAI1 N-acetyl-D-glucosamine kinase YP_002386609.1 1220387 D 585034 CDS YP_002386610.1 218553697 7127787 1221314..1222135 1 NC_011741.1 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1222135 cobB 7127787 cobB Escherichia coli IAI1 NAD-dependent deacetylase YP_002386610.1 1221314 D 585034 CDS YP_002386611.1 218553698 7126345 complement(1222274..1222996) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1222996 ycfZ 7126345 ycfZ Escherichia coli IAI1 hypothetical protein YP_002386611.1 1222274 R 585034 CDS YP_002386612.1 218553699 7127788 complement(1223059..1223529) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1223529 7127788 ECIAI1_1159 Escherichia coli IAI1 hypothetical protein YP_002386612.1 1223059 R 585034 CDS YP_002386613.1 218553700 7128642 complement(1223578..1224624) 1 NC_011741.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter periplasmic substrate-binding protein 1224624 potD 7128642 potD Escherichia coli IAI1 spermidine/putrescine ABC transporter periplasmic substrate-binding protein YP_002386613.1 1223578 R 585034 CDS YP_002386614.1 218553701 7126116 complement(1224621..1225415) 1 NC_011741.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein 1225415 potC 7126116 potC Escherichia coli IAI1 spermidine/putrescine ABC transporter membrane protein YP_002386614.1 1224621 R 585034 CDS YP_002386615.1 218553702 7126115 complement(1225412..1226239) 1 NC_011741.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein 1226239 potB 7126115 potB Escherichia coli IAI1 spermidine/putrescine ABC transporter membrane protein YP_002386615.1 1225412 R 585034 CDS YP_002386616.1 218553703 7126114 complement(1226253..1227389) 1 NC_011741.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase 1227389 potA 7126114 potA Escherichia coli IAI1 putrescine/spermidine ABC transporter ATPase YP_002386616.1 1226253 R 585034 CDS YP_002386617.1 218553704 7126113 complement(1227368..1227619) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 1227619 7126113 ECIAI1_1164 Escherichia coli IAI1 hypothetical protein YP_002386617.1 1227368 R 585034 CDS YP_002386618.1 218553705 7128643 1227597..1228868 1 NC_011741.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1228868 pepT 7128643 pepT Escherichia coli IAI1 peptidase T YP_002386618.1 1227597 D 585034 CDS YP_002386619.1 218553706 7124176 complement(1229014..1230135) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1230135 ycfD 7124176 ycfD Escherichia coli IAI1 hypothetical protein YP_002386619.1 1229014 R 585034 CDS YP_002386620.1 218553707 7127776 complement(1230211..1231671) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92105017; Product type r : regulator; sensor protein PhoQ 1231671 phoQ 7127776 phoQ Escherichia coli IAI1 sensor protein PhoQ YP_002386620.1 1230211 R 585034 CDS YP_002386621.1 218553708 7124219 complement(1231671..1232342) 1 NC_011741.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP 1232342 phoP 7124219 phoP Escherichia coli IAI1 DNA-binding transcriptional regulator PhoP YP_002386621.1 1231671 R 585034 CDS YP_002386622.1 218553709 7124218 complement(1232510..1233880) 1 NC_011741.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1233880 purB 7124218 purB Escherichia coli IAI1 adenylosuccinate lyase YP_002386622.1 1232510 R 585034 CDS YP_002386623.1 218553710 7126545 complement(1233884..1234525) 1 NC_011741.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 1234525 hflD 7126545 hflD Escherichia coli IAI1 hypothetical protein YP_002386623.1 1233884 R 585034 CDS YP_002386624.1 218553711 7128519 complement(1234561..1235667) 1 NC_011741.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 1235667 mnmA 7128519 mnmA Escherichia coli IAI1 tRNA-specific 2-thiouridylase MnmA YP_002386624.1 1234561 R 585034 CDS YP_002386625.1 218553712 7127493 complement(1235721..1236182) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217; Product type e : enzyme; bifunctional thiamin pyrimidine pyrophosphate hydrolase and thiamin pyrophosphate hydrolase 1236182 ymfB 7127493 ymfB Escherichia coli IAI1 bifunctional thiamin pyrimidine pyrophosphate hydrolase and thiamin pyrophosphate hydrolase YP_002386625.1 1235721 R 585034 CDS YP_002386626.1 218553713 7126680 complement(1236192..1236845) 1 NC_011741.1 catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E 1236845 ymfC 7126680 ymfC Escherichia coli IAI1 23S rRNA pseudouridine synthase E YP_002386626.1 1236192 R 585034 CDS YP_002386627.1 218553714 7126681 1237017..1238267 1 NC_011741.1 Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1238267 icd 7126681 icd Escherichia coli IAI1 isocitrate dehydrogenase YP_002386627.1 1237017 D 585034 CDS YP_002386628.1 218553715 7126043 complement(1239389..1239793) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1239793 ycgX 7126043 ycgX Escherichia coli IAI1 hypothetical protein YP_002386628.1 1239389 R 585034 CDS YP_002386629.1 218553716 7127801 complement(1240014..1240745) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1240745 ycgE 7127801 ycgE Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002386629.1 1240014 R 585034 CDS YP_002386630.1 218553717 7127790 complement(1240655..1240807) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 1240807 7127790 ECIAI1_1177 Escherichia coli IAI1 hypothetical protein YP_002386630.1 1240655 R 585034 CDS YP_002386631.1 218553718 7128644 complement(1240950..1242161) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16533062, 15453820; Product type pe : putative enzyme; putative cyclic di-GMP phosphodiesterase 1242161 ycgF 7128644 ycgF Escherichia coli IAI1 putative cyclic di-GMP phosphodiesterase YP_002386631.1 1240950 R 585034 CDS YP_002386632.1 218553719 7127791 1242475..1242711 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1242711 ycgZ 7127791 ycgZ Escherichia coli IAI1 hypothetical protein YP_002386632.1 1242475 D 585034 CDS YP_002386633.1 218553720 7127803 1242754..1243026 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1243026 ymgA 7127803 ymgA Escherichia coli IAI1 hypothetical protein YP_002386633.1 1242754 D 585034 CDS YP_002386634.1 218553721 7126682 1243055..1243321 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1243321 ymgB 7126682 ymgB Escherichia coli IAI1 hypothetical protein YP_002386634.1 1243055 D 585034 CDS YP_002386635.1 218553722 7126683 1243434..1243682 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1243682 ymgC 7126683 ymgC Escherichia coli IAI1 hypothetical protein YP_002386635.1 1243434 D 585034 CDS YP_002386636.1 218553723 7126684 1244014..1245537 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1245537 ycgG 7126684 ycgG Escherichia coli IAI1 hypothetical protein YP_002386636.1 1244014 D 585034 CDS YP_002386637.1 218553724 7127792 1245669..1245887 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1245887 ymgF 7127792 ymgF Escherichia coli IAI1 hypothetical protein YP_002386637.1 1245669 D 585034 CDS YP_002386638.1 218553725 7127613 1246287..1246496 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1246496 7127613 ECIAI1_1185 Escherichia coli IAI1 hypothetical protein YP_002386638.1 1246287 D 585034 CDS YP_002386639.1 218553726 7128645 1246613..1248934 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane autotransporter barrel pectin lyase fold 1248934 7128645 ECIAI1_1186 Escherichia coli IAI1 putative outer membrane autotransporter barrel pectin lyase fold YP_002386639.1 1246613 D 585034 CDS YP_002386640.1 218553727 7128646 complement(1248991..1249320) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1249320 ymgD 7128646 ymgD Escherichia coli IAI1 hypothetical protein YP_002386640.1 1248991 R 585034 CDS YP_002386641.1 218553728 7126685 complement(1249330..1249605) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1249605 ymgG 7126685 ymgG Escherichia coli IAI1 hypothetical protein YP_002386641.1 1249330 R 585034 CDS YP_002386642.1 218553729 7127532 1250151..1250594 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1250594 7127532 ECIAI1_1189 Escherichia coli IAI1 hypothetical protein YP_002386642.1 1250151 D 585034 CDS YP_002386643.1 218553730 7128647 complement(1250966..1251232) 1 NC_011741.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 1251232 minE 7128647 minE Escherichia coli IAI1 cell division topological specificity factor MinE YP_002386643.1 1250966 R 585034 CDS YP_002386644.1 218553731 7124277 complement(1251236..1252048) 1 NC_011741.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD 1252048 minD 7124277 minD Escherichia coli IAI1 cell division inhibitor MinD YP_002386644.1 1251236 R 585034 CDS YP_002386645.1 218553732 7124276 complement(1252072..1252767) 1 NC_011741.1 blocks the formation of polar Z-ring septums; septum formation inhibitor 1252767 minC 7124276 minC Escherichia coli IAI1 septum formation inhibitor YP_002386645.1 1252072 R 585034 CDS YP_002386646.1 218553733 7124275 1253287..1253655 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1253655 ycgJ 7124275 ycgJ Escherichia coli IAI1 hypothetical protein YP_002386646.1 1253287 D 585034 CDS YP_002386647.1 218553734 7127793 complement(1253775..1254176) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1254176 ycgK 7127793 ycgK Escherichia coli IAI1 hypothetical protein YP_002386647.1 1253775 R 585034 CDS YP_002386648.1 218553735 7127794 1254385..1254711 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1254711 ycgL 7127794 ycgL Escherichia coli IAI1 hypothetical protein YP_002386648.1 1254385 D 585034 CDS YP_002386649.1 218553736 7127795 1254783..1255442 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15551868; Product type pe : putative enzyme; hypothetical protein 1255442 ycgM 7127795 ycgM Escherichia coli IAI1 hypothetical protein YP_002386649.1 1254783 D 585034 CDS YP_002386650.1 218553737 7127796 1255534..1255980 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1255980 ycgN 7127796 ycgN Escherichia coli IAI1 hypothetical protein YP_002386650.1 1255534 D 585034 CDS YP_002386651.1 218553738 7124432 1257470..1257889 1 NC_011741.1 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1257889 umuD 7124432 umuD Escherichia coli IAI1 DNA polymerase V subunit UmuD YP_002386651.1 1257470 D 585034 CDS YP_002386652.1 218553739 7125544 1257889..1259157 1 NC_011741.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1259157 umuC 7125544 umuC Escherichia coli IAI1 DNA polymerase V subunit UmuC YP_002386652.1 1257889 D 585034 CDS YP_002386653.1 218553740 7125543 complement(1259203..1259733) 1 NC_011741.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 1259733 dsbB 7125543 dsbB Escherichia coli IAI1 disulfide bond formation protein B YP_002386653.1 1259203 R 585034 CDS YP_002386654.1 218553741 7124623 complement(1259879..1261420) 1 NC_011741.1 involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter 1261420 nhaB 7124623 nhaB Escherichia coli IAI1 sodium/proton antiporter YP_002386654.1 1259879 R 585034 CDS YP_002386655.1 218553742 7127874 1261642..1262361 1 NC_011741.1 Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1262361 fadR 7127874 fadR Escherichia coli IAI1 fatty acid metabolism regulator YP_002386655.1 1261642 D 585034 CDS YP_002386656.1 218553743 7127067 complement(1262413..1263945) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; SpoVR family protein 1263945 ycgB 7127067 ycgB Escherichia coli IAI1 SpoVR family protein YP_002386656.1 1262413 R 585034 CDS YP_002386657.1 218553744 7127789 1264275..1265573 1 NC_011741.1 catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1265573 dadA 7127789 dadA Escherichia coli IAI1 D-amino acid dehydrogenase small subunit YP_002386657.1 1264275 D 585034 CDS YP_002386658.1 218553745 7126912 1265583..1266653 1 NC_011741.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA; alanine racemase 1266653 dadX 7126912 dadX Escherichia coli IAI1 alanine racemase YP_002386658.1 1265583 D 585034 CDS YP_002386659.1 218553746 7126913 complement(1267039..1268775) 1 NC_011741.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter 1268775 cvrA 7126913 cvrA Escherichia coli IAI1 potassium/proton antiporter YP_002386659.1 1267039 R 585034 CDS YP_002386660.1 218553747 7126868 complement(1268870..1269784) 1 NC_011741.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A 1269784 ldcA 7126868 ldcA Escherichia coli IAI1 L,D-carboxypeptidase A YP_002386660.1 1268870 R 585034 CDS YP_002386661.1 218553748 7126397 1269884..1270495 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98317285; Product type e : enzyme; lytic murein endotransglycosylase E 1270495 emtA 7126397 emtA Escherichia coli IAI1 lytic murein endotransglycosylase E YP_002386661.1 1269884 D 585034 CDS YP_002386662.1 218553749 7125065 complement(1270497..1271231) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11031114; Product type cp : cell process; flagellar function protein 1271231 ycgR 7125065 ycgR Escherichia coli IAI1 flagellar function protein YP_002386662.1 1270497 R 585034 CDS YP_002386663.1 218553750 7127798 1271432..1271686 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative inner membrane protein with transglycosylase-associated domain 1271686 ymgE 7127798 ymgE Escherichia coli IAI1 putative inner membrane protein with transglycosylase-associated domain YP_002386663.1 1271432 D 585034 CDS YP_002386664.1 218553751 7126686 1271864..1272304 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1272304 ycgY 7126686 ycgY Escherichia coli IAI1 hypothetical protein YP_002386664.1 1271864 D 585034 CDS YP_002386665.1 218553752 7127802 complement(1272383..1274080) 1 NC_011741.1 periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell; trehalase 1274080 treA 7127802 treA Escherichia coli IAI1 trehalase YP_002386665.1 1272383 R 585034 CDS YP_002386666.1 218553753 7127479 complement(1274400..1275818) 1 NC_011741.1 phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL; dihydroxyacetone kinase subunit M 1275818 dhaH 7127479 dhaH Escherichia coli IAI1 dihydroxyacetone kinase subunit M YP_002386666.1 1274400 R 585034 CDS YP_002386667.1 218553754 7124579 complement(1275829..1276461) 1 NC_011741.1 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL 1276461 dhaL 7124579 dhaL Escherichia coli IAI1 dihydroxyacetone kinase subunit DhaL YP_002386667.1 1275829 R 585034 CDS YP_002386668.1 218553755 7124581 complement(1276472..1277542) 1 NC_011741.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 1277542 dhaK 7124581 dhaK Escherichia coli IAI1 dihydroxyacetone kinase subunit DhaK YP_002386668.1 1276472 R 585034 CDS YP_002386669.1 218553756 7124580 1277770..1279689 1 NC_011741.1 Positively regulates the dhaKLM operon from a sigma-70 promoter; DNA-binding transcriptional regulator DhaR 1279689 dhaR 7124580 dhaR Escherichia coli IAI1 DNA-binding transcriptional regulator DhaR YP_002386669.1 1277770 D 585034 CDS YP_002386670.1 218553757 7127800 complement(1283498..1284589) 1 NC_011741.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 1284589 ychF 7127800 ychF Escherichia coli IAI1 GTP-dependent nucleic acid-binding protein EngD YP_002386670.1 1283498 R 585034 CDS YP_002386671.1 218553758 7127806 complement(1284706..1285290) 1 NC_011741.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 1285290 pth 7127806 pth Escherichia coli IAI1 peptidyl-tRNA hydrolase YP_002386671.1 1284706 R 585034 CDS YP_002386672.1 218553759 7126535 1285568..1285846 1 NC_011741.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 1285846 ychH 7126535 ychH Escherichia coli IAI1 hypothetical protein YP_002386672.1 1285568 D 585034 CDS YP_002386673.1 218553760 7127807 complement(1285901..1287580) 1 NC_011741.1 putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; putative sulfate transporter YchM 1287580 ychM 7127807 ychM Escherichia coli IAI1 putative sulfate transporter YchM YP_002386673.1 1285901 R 585034 CDS YP_002386674.1 218553761 7127809 complement(1287705..1288652) 1 NC_011741.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1288652 prsA 7127809 prsA Escherichia coli IAI1 ribose-phosphate pyrophosphokinase YP_002386674.1 1287705 R 585034 CDS YP_002386675.1 218553762 7126171 complement(1288803..1289654) 1 NC_011741.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1289654 ipk 7126171 ipk Escherichia coli IAI1 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_002386675.1 1288803 R 585034 CDS YP_002386676.1 218553763 7126082 complement(1289654..1290277) 1 NC_011741.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB 1290277 lolB 7126082 lolB Escherichia coli IAI1 outer membrane lipoprotein LolB YP_002386676.1 1289654 R 585034 CDS YP_002386677.1 218553764 7126434 1290491..1291747 1 NC_011741.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1291747 hemA 7126434 hemA Escherichia coli IAI1 glutamyl-tRNA reductase YP_002386677.1 1290491 D 585034 CDS YP_002386678.1 218553765 7128505 1291789..1292871 1 NC_011741.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1292871 prfA 7128505 prfA Escherichia coli IAI1 peptide chain release factor 1 YP_002386678.1 1291789 D 585034 CDS YP_002386679.1 218553766 7126144 1292871..1293704 1 NC_011741.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1293704 prmC 7126144 prmC Escherichia coli IAI1 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_002386679.1 1292871 D 585034 CDS YP_002386680.1 218553767 7126155 1293701..1294093 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10322010; Product type pr : putative regulator; putative transcriptional regulator 1294093 ychQ 7126155 ychQ Escherichia coli IAI1 putative transcriptional regulator YP_002386680.1 1293701 D 585034 CDS YP_002386681.1 218553768 7127812 1294097..1294906 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10322010; Product type pr : putative regulator; putative transcriptional regulator 1294906 ychA 7127812 ychA Escherichia coli IAI1 putative transcriptional regulator YP_002386681.1 1294097 D 585034 CDS YP_002386682.1 218553769 7127804 1294942..1295796 1 NC_011741.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1295796 kdsA 7127804 kdsA Escherichia coli IAI1 2-dehydro-3-deoxyphosphooctonate aldolase YP_002386682.1 1294942 D 585034 CDS YP_002386683.1 218553770 7126378 complement(1295945..1296052) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type f : factor; toxic polypeptide, small 1296052 ldrB 7126378 ldrB Escherichia coli IAI1 toxic polypeptide, small YP_002386683.1 1295945 R 585034 CDS YP_002386684.1 218553771 7126604 complement(1296457..1297557) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93266586, 94193576, 94292460; Product type t : transporter; calcium/sodium:proton antiporter 1297557 chaA 7126604 chaA Escherichia coli IAI1 calcium/sodium:proton antiporter YP_002386684.1 1296457 R 585034 CDS YP_002386685.1 218553772 7126300 1297827..1298057 1 NC_011741.1 in Escherichia coli this protein putatively regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1298057 chaB 7126300 chaB Escherichia coli IAI1 cation transport regulator YP_002386685.1 1297827 D 585034 CDS YP_002386686.1 218553773 7126301 1298194..1298910 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type r : regulator; regulatory protein for cation transport 1298910 chaC 7126301 chaC Escherichia coli IAI1 regulatory protein for cation transport YP_002386686.1 1298194 D 585034 CDS YP_002386687.1 218553774 7126302 complement(1298954..1299307) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1299307 ychN 7126302 ychN Escherichia coli IAI1 hypothetical protein YP_002386687.1 1298954 R 585034 CDS YP_002386688.1 218553775 7127810 1299633..1300886 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pf : putative factor; hypothetical protein 1300886 ychP 7127810 ychP Escherichia coli IAI1 hypothetical protein YP_002386688.1 1299633 D 585034 CDS YP_002386689.1 218553776 7127811 complement(1300887..1301537) 1 NC_011741.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL 1301537 narL 7127811 narL Escherichia coli IAI1 transcriptional regulator NarL YP_002386689.1 1300887 R 585034 CDS YP_002386690.1 218553777 7124540 complement(1301530..1303326) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92276349, 92374842, 94083940, 2649492, 2657652, 2668029; Product type r : regulator; nitrate/nitrite sensor protein NarX 1303326 narX 7124540 narX Escherichia coli IAI1 nitrate/nitrite sensor protein NarX YP_002386690.1 1301530 R 585034 CDS YP_002386691.1 218553778 7127860 1303352..1303570 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1303570 7127860 ECIAI1_1245 Escherichia coli IAI1 hypothetical protein YP_002386691.1 1303352 D 585034 CDS YP_002386692.1 218553779 7128648 1303665..1305056 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91258310, 2657652, 2668029; Product type t : transporter; nitrate/nitrite transporter 1305056 narK 7128648 narK Escherichia coli IAI1 nitrate/nitrite transporter YP_002386692.1 1303665 D 585034 CDS YP_002386693.1 218553780 7124539 1305572..1309315 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 74167294, 89384449, 92121125, 2233673, 2668029, 2995309, 3053688, 3308846, 6094247; Product type e : enzyme; nitrate reductase 1 subunit alpha 1309315 narG 7124539 narG Escherichia coli IAI1 nitrate reductase 1 subunit alpha YP_002386693.1 1305572 D 585034 CDS YP_002386694.1 218553781 7124535 1309312..1310850 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 74167294, 89384449, 92121125, 1321049, 2832376, 3053688, 8383531, 8388253, 8664273, 9516445; Product type c : carrier; nitrate reductase 1, beta (Fe-S) subunit 1310850 narH 7124535 narH Escherichia coli IAI1 nitrate reductase 1, beta (Fe-S) subunit YP_002386694.1 1309312 D 585034 CDS YP_002386695.1 218553782 7124536 1310847..1311557 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89384449, 92121125, 9632249, 2832376; Product type f : factor; molybdenum-cofactor-assembly chaperone subunit (delta subunit) of nitrate reductase 1 1311557 narJ 7124536 narJ Escherichia coli IAI1 molybdenum-cofactor-assembly chaperone subunit (delta subunit) of nitrate reductase 1 YP_002386695.1 1310847 D 585034 CDS YP_002386696.1 218553783 7124538 1311557..1312234 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 75114694, 89384449, 92121125, 2832376, 3053688; Product type c : carrier; nitrate reductase 1, gamma (cytochrome b(NR)) subunit 1312234 narI 7124538 narI Escherichia coli IAI1 nitrate reductase 1, gamma (cytochrome b(NR)) subunit YP_002386696.1 1311557 D 585034 CDS YP_002386697.1 218553784 7128055 complement(1312960..1313802) 1 NC_011741.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 1313802 purU 7128055 purU Escherichia coli IAI1 formyltetrahydrofolate deformylase YP_002386697.1 1312960 R 585034 CDS YP_002386698.1 218553785 7126557 complement(1313852..1314310) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1314310 ychJ 7126557 ychJ Escherichia coli IAI1 hypothetical protein YP_002386698.1 1313852 R 585034 CDS YP_002386699.1 218553786 7127808 1314384..1315328 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 1315328 rssA 7127808 rssA Escherichia coli IAI1 hypothetical protein YP_002386699.1 1314384 D 585034 CDS YP_002386700.1 218553787 7128442 1315420..1316433 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339606, 12912910, 9495753; Product type r : regulator; response regulator of RpoS 1316433 rssB 7128442 rssB Escherichia coli IAI1 response regulator of RpoS YP_002386700.1 1315420 D 585034 CDS YP_002386701.1 218553788 7128443 1316635..1317543 1 NC_011741.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalU 1317543 galU 7128443 galU Escherichia coli IAI1 UTP--glucose-1-phosphate uridylyltransferase subunit GalU YP_002386701.1 1316635 D 585034 CDS YP_002386702.1 218553789 7128276 complement(1317687..1318100) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 94335643, 95267838, 95286558, 99355427, 2404280, 11298273; Product type r : regulator; global DNA-binding transcriptional dual regulator H-NS 1318100 hns 7128276 hns Escherichia coli IAI1 global DNA-binding transcriptional dual regulator H-NS YP_002386702.1 1317687 R 585034 CDS YP_002386703.1 218553790 7125286 1318705..1319322 1 NC_011741.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1319322 tdk 7125286 tdk Escherichia coli IAI1 thymidine kinase YP_002386703.1 1318705 D 585034 CDS YP_002386704.1 218553791 7126233 complement(1319624..1322299) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12783863, 4301680, 89291706, 91200315; Product type e : enzyme; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1322299 adhE 7126233 adhE Escherichia coli IAI1 bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_002386704.1 1319624 R 585034 CDS YP_002386705.1 218553792 7125717 1322776..1323423 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1323423 ychE 7125717 ychE Escherichia coli IAI1 hypothetical protein YP_002386705.1 1322776 D 585034 CDS YP_002386706.1 218553793 7127805 complement(1323581..1323895) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1323895 7127805 ECIAI1_1261 Escherichia coli IAI1 hypothetical protein YP_002386706.1 1323581 R 585034 CDS YP_002386707.1 218553794 7128649 1324161..1325792 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20256410, 86111605, 90256748, 92325017, 2015910, 9298646, 9600841, 2187863, 8740179, 9740056, 10972807; Product type t : transporter; oligopeptide ABC transporter periplasmic-binding protein 1325792 oppA 7128649 oppA Escherichia coli IAI1 oligopeptide ABC transporter periplasmic-binding protein YP_002386707.1 1324161 D 585034 CDS YP_002386708.1 218553795 7125989 1325878..1326798 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606, 93106975, 2187863; Product type t : transporter; oligopeptide transporter permease 1326798 oppB 7125989 oppB Escherichia coli IAI1 oligopeptide transporter permease YP_002386708.1 1325878 D 585034 CDS YP_002386709.1 218553796 7125990 1326813..1327721 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide ABC transporter membrane protein 1327721 oppC 7125990 oppC Escherichia coli IAI1 oligopeptide ABC transporter membrane protein YP_002386709.1 1326813 D 585034 CDS YP_002386710.1 218553797 7125991 1327733..1328746 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide transporter ATP-binding protein 1328746 oppD 7125991 oppD Escherichia coli IAI1 oligopeptide transporter ATP-binding protein YP_002386710.1 1327733 D 585034 CDS YP_002386711.1 218553798 7125992 1328743..1329747 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide ABC transporter ATP-binding protein 1329747 oppF 7125992 oppF Escherichia coli IAI1 oligopeptide ABC transporter ATP-binding protein YP_002386711.1 1328743 D 585034 CDS YP_002386712.1 218553799 7125993 complement(1329800..1330129) 1 NC_011741.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 1330129 yciU 7125993 yciU Escherichia coli IAI1 dsDNA-mimic protein YP_002386712.1 1329800 R 585034 CDS YP_002386713.1 218553800 7127827 complement(1330164..1331624) 1 NC_011741.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase 1331624 cls 7127827 cls Escherichia coli IAI1 cardiolipin synthetase YP_002386713.1 1330164 R 585034 CDS YP_002386714.1 218553801 7126337 1331656..1331940 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1331940 7126337 ECIAI1_1269 Escherichia coli IAI1 hypothetical protein YP_002386714.1 1331656 D 585034 CDS YP_002386715.1 218553802 7128650 complement(1331995..1333248) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12220501, 12912904, 94224769, 98319474; Product type t : transporter; voltage-gated potassium channel 1333248 kch 7128650 kch Escherichia coli IAI1 voltage-gated potassium channel YP_002386715.1 1331995 R 585034 CDS YP_002386716.1 218553803 7126178 complement(1333548..1333844) 1 NC_011741.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; YciI-like protein 1333844 yciI 7126178 yciI Escherichia coli IAI1 YciI-like protein YP_002386716.1 1333548 R 585034 CDS YP_002386717.1 218553804 7127821 1334068..1334787 1 NC_011741.1 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transport protein TonB 1334787 tonB 7127821 tonB Escherichia coli IAI1 transport protein TonB YP_002386717.1 1334068 D 585034 CDS YP_002386718.1 218553805 7127463 complement(1334827..1335225) 1 NC_011741.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins; acyl-CoA thioester hydrolase 1335225 yciA 7127463 yciA Escherichia coli IAI1 acyl-CoA thioester hydrolase YP_002386718.1 1334827 R 585034 CDS YP_002386719.1 218553806 7127814 complement(1335330..1335869) 1 NC_011741.1 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 1335869 yciB 7127814 yciB Escherichia coli IAI1 intracellular septation protein A YP_002386719.1 1335330 R 585034 CDS YP_002386720.1 218553807 7127815 complement(1335899..1336642) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1336642 yciC 7127815 yciC Escherichia coli IAI1 hypothetical protein YP_002386720.1 1335899 R 585034 CDS YP_002386721.1 218553808 7127816 1336999..1337637 1 NC_011741.1 receptor for colicin S4; outer membrane protein W 1337637 ompW 7127816 ompW Escherichia coli IAI1 outer membrane protein W YP_002386721.1 1336999 D 585034 CDS YP_002386722.1 218553809 7125985 complement(1337697..1338203) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15388941, 3058546, 8455549; hypothetical protein 1338203 yciE 7125985 yciE Escherichia coli IAI1 hypothetical protein YP_002386722.1 1337697 R 585034 CDS YP_002386723.1 218553810 7127817 complement(1338249..1338749) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3058546, 8455549; hypothetical protein 1338749 yciF 7127817 yciF Escherichia coli IAI1 hypothetical protein YP_002386723.1 1338249 R 585034 CDS YP_002386724.1 218553811 7127818 complement(1338835..1339014) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1339014 yciG 7127818 yciG Escherichia coli IAI1 hypothetical protein YP_002386724.1 1338835 R 585034 CDS YP_002386725.1 218553812 7127819 complement(1339395..1340201) 1 NC_011741.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1340201 trpA 7127819 trpA Escherichia coli IAI1 tryptophan synthase subunit alpha YP_002386725.1 1339395 R 585034 CDS YP_002386726.1 218553813 7127494 complement(1340201..1341394) 1 NC_011741.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1341394 trpB 7127494 trpB Escherichia coli IAI1 tryptophan synthase subunit beta YP_002386726.1 1340201 R 585034 CDS YP_002386727.1 218553814 7127495 complement(1341406..1342764) 1 NC_011741.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1342764 trpC 7127495 trpC Escherichia coli IAI1 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase YP_002386727.1 1341406 R 585034 CDS YP_002386728.1 218553815 7127496 complement(1342768..1344363) 1 NC_011741.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase 1344363 trpD 7127496 trpD Escherichia coli IAI1 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase YP_002386728.1 1342768 R 585034 CDS YP_002386729.1 218553816 7127497 complement(1344363..1345925) 1 NC_011741.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1345925 trpE 7127497 trpE Escherichia coli IAI1 anthranilate synthase component I YP_002386729.1 1344363 R 585034 CDS YP_002386731.1 218553818 7127499 1346199..1347080 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1347080 yciV 7127499 yciV Escherichia coli IAI1 hypothetical protein YP_002386731.1 1346199 D 585034 CDS YP_002386732.1 218553819 7127828 1347077..1347697 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1347697 yciO 7127828 yciO Escherichia coli IAI1 hypothetical protein YP_002386732.1 1347077 D 585034 CDS YP_002386733.1 218553820 7127825 1347771..1348670 1 NC_011741.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1348670 rluB 7127825 rluB Escherichia coli IAI1 23S rRNA pseudouridylate synthase B YP_002386733.1 1347771 D 585034 CDS YP_002386734.1 218553821 7125010 complement(1348710..1349300) 1 NC_011741.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 1349300 btuR 7125010 btuR Escherichia coli IAI1 cob(I)yrinic acid a,c-diamide adenosyltransferase YP_002386734.1 1348710 R 585034 CDS YP_002386735.1 218553822 7124428 complement(1349297..1350055) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; short chain dehydrogenase 1350055 yciK 7124428 yciK Escherichia coli IAI1 short chain dehydrogenase YP_002386735.1 1349297 R 585034 CDS YP_002386736.1 218553823 7127822 complement(1350099..1350263) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 1350263 7127822 ECIAI1_1290 Escherichia coli IAI1 hypothetical protein YP_002386736.1 1350099 R 585034 CDS YP_002386737.1 218553824 7128651 1350275..1351324 1 NC_011741.1 SohB; periplasmic protein; member of the peptidase S49 family; putative periplasmic protease 1351324 sohB 7128651 sohB Escherichia coli IAI1 putative periplasmic protease YP_002386737.1 1350275 D 585034 CDS YP_002386738.1 218553825 7127945 complement(1351360..1351611) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3029379, 7567469, 9868784; hypothetical protein 1351611 yciN 7127945 yciN Escherichia coli IAI1 hypothetical protein YP_002386738.1 1351360 R 585034 CDS YP_002386739.1 218553826 7127824 1351656..1351868 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 1351868 7127824 ECIAI1_1293 Escherichia coli IAI1 hypothetical protein YP_002386739.1 1351656 D 585034 CDS YP_002386740.1 218553827 7128652 1351991..1354588 1 NC_011741.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1354588 topA 7128652 topA Escherichia coli IAI1 DNA topoisomerase I YP_002386740.1 1351991 D 585034 CDS YP_002386741.1 218553828 7127464 1354798..1355772 1 NC_011741.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1355772 cysB 7127464 cysB Escherichia coli IAI1 transcriptional regulator CysB YP_002386741.1 1354798 D 585034 CDS YP_002386742.1 218553829 7126888 1356066..1356230 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1356230 7126888 ECIAI1_1296 Escherichia coli IAI1 hypothetical protein YP_002386742.1 1356066 D 585034 CDS YP_002386743.1 218553830 7128653 1356212..1356400 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1356400 7128653 ECIAI1_1297 Escherichia coli IAI1 hypothetical protein YP_002386743.1 1356212 D 585034 CDS YP_002386744.1 218553831 7128654 1356537..1356719 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 1356719 7128654 ECIAI1_1298 Escherichia coli IAI1 hypothetical protein YP_002386744.1 1356537 D 585034 CDS YP_002386745.1 218553832 7128655 1356773..1359448 1 NC_011741.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1359448 acnA 7128655 acnA Escherichia coli IAI1 aconitate hydratase YP_002386745.1 1356773 D 585034 CDS YP_002386746.1 218553833 7125700 complement(1359512..1360102) 1 NC_011741.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 1360102 ribA 7125700 ribA Escherichia coli IAI1 GTP cyclohydrolase II YP_002386746.1 1359512 R 585034 CDS YP_002386747.1 218553834 7124992 1360272..1361036 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89033893, 92104964; Product type e : enzyme; phosphatidylglycerophosphatase B 1361036 pgpB 7124992 pgpB Escherichia coli IAI1 phosphatidylglycerophosphatase B YP_002386747.1 1360272 D 585034 CDS YP_002386748.1 218553835 7124190 1361185..1361493 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1361493 yciS 7124190 yciS Escherichia coli IAI1 hypothetical protein YP_002386748.1 1361185 D 585034 CDS YP_002386749.1 218553836 7127826 1361500..1362669 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1362669 yciM 7127826 yciM Escherichia coli IAI1 hypothetical protein YP_002386749.1 1361500 D 585034 CDS YP_002386750.1 218553837 7127823 1362862..1363599 1 NC_011741.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1363599 pyrF 7127823 pyrF Escherichia coli IAI1 orotidine 5'-phosphate decarboxylase YP_002386750.1 1362862 D 585034 CDS YP_002386751.1 218553838 7126573 1363599..1363925 1 NC_011741.1 involved in start site selection during the initiation of translation; translation initiation factor Sui1 1363925 yciH 7126573 yciH Escherichia coli IAI1 translation initiation factor Sui1 YP_002386751.1 1363599 D 585034 CDS YP_002386752.1 218553839 7127820 1363949..1364101 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1364101 7127820 ECIAI1_1306 Escherichia coli IAI1 hypothetical protein YP_002386752.1 1363949 D 585034 CDS YP_002386753.1 218553840 7128656 complement(1364051..1364269) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92078100, 2644204; Product type lp : lipoprotein; lipoprotein 1364269 osmB 7128656 osmB Escherichia coli IAI1 lipoprotein YP_002386753.1 1364051 R 585034 CDS YP_002386754.1 218553841 7125995 complement(1364538..1365287) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16451192; Product type r : regulator; DNA-binding transcriptional repressor, DeoR family 1365287 deoT 7125995 deoT Escherichia coli IAI1 DNA-binding transcriptional repressor, DeoR family YP_002386754.1 1364538 R 585034 CDS YP_002386755.1 218553842 7124568 complement(1365377..1365592) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1365592 7124568 ECIAI1_1309 Escherichia coli IAI1 hypothetical protein YP_002386755.1 1365377 R 585034 CDS YP_002386756.1 218553843 7128657 complement(1365697..1367682) 1 NC_011741.1 c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP; RNase II stability modulator 1367682 gmr 7128657 gmr Escherichia coli IAI1 RNase II stability modulator YP_002386756.1 1365697 R 585034 CDS YP_002386757.1 218553844 7128364 complement(1367918..1369852) 1 NC_011741.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II 1369852 rnb 7128364 rnb Escherichia coli IAI1 exoribonuclease II YP_002386757.1 1367918 R 585034 CDS YP_002386758.1 218553845 7125016 complement(1369920..1371047) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amidase or amidotransferase 1371047 yciW 7125016 yciW Escherichia coli IAI1 putative amidase or amidotransferase YP_002386758.1 1369920 R 585034 CDS YP_002386759.1 218553846 7127829 complement(1371192..1371980) 1 NC_011741.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase 1371980 fabI 7127829 fabI Escherichia coli IAI1 enoyl-(acyl carrier protein) reductase YP_002386759.1 1371192 R 585034 CDS YP_002386760.1 218553847 7127058 complement(1372348..1372701) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1372701 ycjD 7127058 ycjD Escherichia coli IAI1 hypothetical protein YP_002386760.1 1372348 R 585034 CDS YP_002386761.1 218553848 7127830 complement(1372769..1373575) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 10720487, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter ATP-binding protein 1373575 sapF 7127830 sapF Escherichia coli IAI1 antimicrobial peptide ABC transporter ATP-binding protein YP_002386761.1 1372769 R 585034 CDS YP_002386762.1 218553849 7124674 complement(1373577..1374569) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 10720487, 9634580, 1987159; Product type t : transporter; antimicrobial peptide ABC transporter ATP-binding protein 1374569 sapD 7124674 sapD Escherichia coli IAI1 antimicrobial peptide ABC transporter ATP-binding protein YP_002386762.1 1373577 R 585034 CDS YP_002386763.1 218553850 7124673 complement(1374569..1375459) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter permease 1375459 sapC 7124673 sapC Escherichia coli IAI1 antimicrobial peptide ABC transporter permease YP_002386763.1 1374569 R 585034 CDS YP_002386764.1 218553851 7124672 complement(1375446..1376411) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter permease 1376411 sapB 7124672 sapB Escherichia coli IAI1 antimicrobial peptide ABC transporter permease YP_002386764.1 1375446 R 585034 CDS YP_002386765.1 218553852 7124671 complement(1376408..1378051) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter periplasmic-binding protein 1378051 sapA 7124671 sapA Escherichia coli IAI1 antimicrobial peptide ABC transporter periplasmic-binding protein YP_002386765.1 1376408 R 585034 CDS YP_002386766.1 218553853 7124670 complement(1378363..1378608) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1378608 ymjA 7124670 ymjA Escherichia coli IAI1 hypothetical protein YP_002386766.1 1378363 R 585034 CDS YP_002386767.1 218553854 7127533 complement(1378742..1380127) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15590624; Product type t : transporter; putrescine importer 1380127 puuP 7127533 puuP Escherichia coli IAI1 putrescine importer YP_002386767.1 1378742 R 585034 CDS YP_002386768.1 218553855 7126565 complement(1380430..1381848) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15590624; Product type e : enzyme; gamma-Glu-putrescine synthase 1381848 puuA 7126565 puuA Escherichia coli IAI1 gamma-Glu-putrescine synthase YP_002386768.1 1380430 R 585034 CDS YP_002386769.1 218553856 7126560 1382060..1382824 1 NC_011741.1 catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate; gamma-glutamyl-gamma-aminobutyrate hydrolase 1382824 puuD 7126560 puuD Escherichia coli IAI1 gamma-glutamyl-gamma-aminobutyrate hydrolase YP_002386769.1 1382060 D 585034 CDS YP_002386770.1 218553857 7126563 1382851..1383408 1 NC_011741.1 regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR 1383408 puuR 7126563 puuR Escherichia coli IAI1 DNA-binding transcriptional repressor PuuR YP_002386770.1 1382851 D 585034 CDS YP_002386771.1 218553858 7126566 1383683..1385170 1 NC_011741.1 catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation; gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 1385170 puuC 7126566 puuC Escherichia coli IAI1 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase YP_002386771.1 1383683 D 585034 CDS YP_002386772.1 218553859 7126562 1385172..1386452 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150200, 15590624; Product type e : enzyme; gamma-Glu-putrescine oxidase 1386452 puuB 7126562 puuB Escherichia coli IAI1 gamma-Glu-putrescine oxidase YP_002386772.1 1385172 D 585034 CDS YP_002386773.1 218553860 7126561 1386490..1387755 1 NC_011741.1 putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate; 4-aminobutyrate transaminase 1387755 puuE 7126561 puuE Escherichia coli IAI1 4-aminobutyrate transaminase YP_002386773.1 1386490 D 585034 CDS YP_002386774.1 218553861 7126564 complement(1387875..1388852) 1 NC_011741.1 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator 1388852 pspF 7126564 pspF Escherichia coli IAI1 phage shock protein operon transcriptional activator YP_002386774.1 1387875 R 585034 CDS YP_002386775.1 218553862 7126528 1389019..1389687 1 NC_011741.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 1389687 pspA 7126528 pspA Escherichia coli IAI1 phage shock protein PspA YP_002386775.1 1389019 D 585034 CDS YP_002386776.1 218553863 7126174 1389741..1389965 1 NC_011741.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B 1389965 pspB 7126174 pspB Escherichia coli IAI1 phage shock protein B YP_002386776.1 1389741 D 585034 CDS YP_002386777.1 218553864 7126175 1389965..1390324 1 NC_011741.1 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; DNA-binding transcriptional activator PspC 1390324 pspC 7126175 pspC Escherichia coli IAI1 DNA-binding transcriptional activator PspC YP_002386777.1 1389965 D 585034 CDS YP_002386778.1 218553865 7126176 1390333..1390554 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91295203, 97303082; Product type ph : phenotype; peripheral inner membrane phage-shock protein 1390554 pspD 7126176 pspD Escherichia coli IAI1 peripheral inner membrane phage-shock protein YP_002386778.1 1390333 D 585034 CDS YP_002386779.1 218553866 7126445 1390629..1390943 1 NC_011741.1 rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 1390943 pspE 7126445 pspE Escherichia coli IAI1 thiosulfate:cyanide sulfurtransferase YP_002386779.1 1390629 D 585034 CDS YP_002386780.1 218553867 7126527 1391155..1392834 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glucosyltransferase 1392834 ycjM 7126527 ycjM Escherichia coli IAI1 putative glucosyltransferase YP_002386780.1 1391155 D 585034 CDS YP_002386781.1 218553868 7127833 1392848..1394140 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter periplasmic-binding protein 1394140 ycjN 7127833 ycjN Escherichia coli IAI1 putative sugar ABC transporter periplasmic-binding protein YP_002386781.1 1392848 D 585034 CDS YP_002386782.1 218553869 7127834 1394161..1395042 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter permease 1395042 ycjO 7127834 ycjO Escherichia coli IAI1 putative sugar ABC transporter permease YP_002386782.1 1394161 D 585034 CDS YP_002386783.1 218553870 7127835 1395029..1395871 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter permease 1395871 ycjP 7127835 ycjP Escherichia coli IAI1 putative sugar ABC transporter permease YP_002386783.1 1395029 D 585034 CDS YP_002386784.1 218553871 7127836 1395902..1396954 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1396954 ycjQ 7127836 ycjQ Escherichia coli IAI1 putative oxidoreductase YP_002386784.1 1395902 D 585034 CDS YP_002386785.1 218553872 7127837 1396972..1397760 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative isomerase/epimerase 1397760 ycjR 7127837 ycjR Escherichia coli IAI1 putative isomerase/epimerase YP_002386785.1 1396972 D 585034 CDS YP_002386786.1 218553873 7127838 1397770..1398825 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1398825 ycjS 7127838 ycjS Escherichia coli IAI1 putative oxidoreductase YP_002386786.1 1397770 D 585034 CDS YP_002386787.1 218553874 7127839 1398822..1401089 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl hydrolase/phosphorylase 1401089 ycjT 7127839 ycjT Escherichia coli IAI1 putative glycosyl hydrolase/phosphorylase YP_002386787.1 1398822 D 585034 CDS YP_002386788.1 218553875 7127840 1401086..1401745 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11972617; Product type pe : putative enzyme; putative glucose-1-phosphate phosphodismutase, beta-phosphoglucomutase 1401745 ycjU 7127840 ycjU Escherichia coli IAI1 putative glucose-1-phosphate phosphodismutase, beta-phosphoglucomutase YP_002386788.1 1401086 D 585034 CDS YP_002386789.1 218553876 7127841 1401759..1402841 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter ATP-binding protein 1402841 ycjV 7127841 ycjV Escherichia coli IAI1 putative sugar ABC transporter ATP-binding protein YP_002386789.1 1401759 D 585034 CDS YP_002386790.1 218553877 7127842 1402886..1403791 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20464934, 89327119, 9721282; Product type t : transporter; outer membrane porin 1403791 ompG 7127842 ompG Escherichia coli IAI1 outer membrane porin YP_002386790.1 1402886 D 585034 CDS YP_002386791.1 218553878 7125981 complement(1403902..1404900) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1404900 ycjW 7125981 ycjW Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002386791.1 1403902 R 585034 CDS YP_002386792.1 218553879 7127843 1405055..1406452 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1406452 ycjX 7127843 ycjX Escherichia coli IAI1 hypothetical protein YP_002386792.1 1405055 D 585034 CDS YP_002386793.1 218553880 7127844 1406449..1407510 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1407510 ycjF 7127844 ycjF Escherichia coli IAI1 hypothetical protein YP_002386793.1 1406449 D 585034 CDS YP_002386794.1 218553881 7127831 1407658..1409199 1 NC_011741.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1409199 tyrR 7127831 tyrR Escherichia coli IAI1 DNA-binding transcriptional regulator TyrR YP_002386794.1 1407658 D 585034 CDS YP_002386795.1 218553882 7127528 complement(1409243..1409749) 1 NC_011741.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1409749 tpx 7127528 tpx Escherichia coli IAI1 thiol peroxidase YP_002386795.1 1409243 R 585034 CDS YP_002386796.1 218553883 7127478 1409868..1410833 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11747447, 11747448, 7499381; Product type e : enzyme; L-Ala-D/L-Glu epimerase 1410833 ycjG 7127478 ycjG Escherichia coli IAI1 L-Ala-D/L-Glu epimerase YP_002386796.1 1409868 D 585034 CDS YP_002386797.1 218553884 7127832 complement(1410808..1411596) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12511517; Product type e : enzyme; murein peptide amidase A 1411596 mpaA 7127832 mpaA Escherichia coli IAI1 murein peptide amidase A YP_002386797.1 1410808 R 585034 CDS YP_002386798.1 218553885 7124462 complement(1411827..1412477) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P) binding enzyme 1412477 ymjC 7124462 ymjC Escherichia coli IAI1 putative NAD(P) binding enzyme YP_002386798.1 1411827 R 585034 CDS YP_002386799.1 218553886 7127846 complement(1414086..1414253) 1 NC_011741.1 hypothetical protein 1414253 7127846 ECIAI1_1355 Escherichia coli IAI1 hypothetical protein YP_002386799.1 1414086 R 585034 CDS YP_002386800.1 218553887 7127847 1414473..1415372 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17366475; Product type pr : putative regulator; putative nucleic acid-binding regulator 1415372 ycjZ 7127847 ycjZ Escherichia coli IAI1 putative nucleic acid-binding regulator YP_002386800.1 1414473 D 585034 CDS YP_002386801.1 218553888 7127848 1415709..1417322 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438753, 9495761; Product type t : transporter; murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) ABC transporter periplasmic-binding protein 1417322 mppA 7127848 mppA Escherichia coli IAI1 murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) ABC transporter periplasmic-binding protein YP_002386801.1 1415709 D 585034 CDS YP_002386802.1 218553889 7124464 complement(1417373..1418404) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1418404 ynaI 7124464 ynaI Escherichia coli IAI1 hypothetical protein YP_002386802.1 1417373 R 585034 CDS YP_002386803.1 218553890 7127535 1418648..1418905 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1418905 ynaJ 7127535 ynaJ Escherichia coli IAI1 hypothetical protein YP_002386803.1 1418648 D 585034 CDS YP_002386804.1 218553891 7127536 complement(1418955..1419905) 1 NC_011741.1 with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 1419905 uspE 7127536 uspE Escherichia coli IAI1 universal stress protein UspE YP_002386804.1 1418955 R 585034 CDS YP_002386805.1 218553892 7125551 complement(1420057..1420809) 1 NC_011741.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 1420809 fnr 7125551 fnr Escherichia coli IAI1 fumarate/nitrate reduction transcriptional regulator YP_002386805.1 1420057 R 585034 CDS YP_002386806.1 218553893 7127255 complement(1421004..1421519) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88067749, 91161525, 94252990, 98125595, 1520330; Product type e : enzyme; O-6-alkylguanine-DNA:cysteine-protein methyltransferase 1421519 ogt 7127255 ogt Escherichia coli IAI1 O-6-alkylguanine-DNA:cysteine-protein methyltransferase YP_002386806.1 1421004 R 585034 CDS YP_002386807.1 218553894 7125977 complement(1421530..1422870) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9829935, 2825131, 7567469; Product type t : transporter; putative aminobenzoyl-glutamate transporter 1422870 abgT 7125977 abgT Escherichia coli IAI1 putative aminobenzoyl-glutamate transporter YP_002386807.1 1421530 R 585034 CDS YP_002386808.1 218553895 7125688 complement(1422985..1423176) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 1423176 7125688 ECIAI1_1365 Escherichia coli IAI1 hypothetical protein YP_002386808.1 1422985 R 585034 CDS YP_002386809.1 218553896 7128659 complement(1423089..1424534) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9829935; Product type pe : putative enzyme; putative peptidase, aminobenzoyl-glutamate utilization protein 1424534 abgB 7128659 abgB Escherichia coli IAI1 putative peptidase, aminobenzoyl-glutamate utilization protein YP_002386809.1 1423089 R 585034 CDS YP_002386810.1 218553897 7125686 complement(1424534..1425844) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9829935; Product type pe : putative enzyme; putative peptidase, para-aminobenzoyl-glutamate utilization protein 1425844 abgA 7125686 abgA Escherichia coli IAI1 putative peptidase, para-aminobenzoyl-glutamate utilization protein YP_002386810.1 1424534 R 585034 CDS YP_002386811.1 218553898 7125685 1426020..1426928 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9829935; Product type r : regulator; putative DNA-binding transcriptional regulator 1426928 abgR 7125685 abgR Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002386811.1 1426020 D 585034 CDS YP_002386812.1 218553899 7126087 1427258..1427821 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1427821 ydaL 7126087 ydaL Escherichia coli IAI1 hypothetical protein YP_002386812.1 1427258 D 585034 CDS YP_002386813.1 218553900 7127849 complement(1427842..1429074) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16045609; Product type pe : putative enzyme; putative diguanylate cyclase 1429074 ydaM 7127849 ydaM Escherichia coli IAI1 putative diguanylate cyclase YP_002386813.1 1427842 R 585034 CDS YP_002386814.1 218553901 7127850 1429329..1430312 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; zinc transporter 1430312 zntB 7127850 zntB Escherichia coli IAI1 zinc transporter YP_002386814.1 1429329 D 585034 CDS YP_002386815.1 218553902 7127851 1430587..1430760 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1430760 7127851 ECIAI1_1372 Escherichia coli IAI1 hypothetical protein YP_002386815.1 1430587 D 585034 CDS YP_002386816.1 218553903 7124433 1430790..1432163 1 NC_011741.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA 1432163 dbpA 7124433 dbpA Escherichia coli IAI1 ATP-dependent RNA helicase DbpA YP_002386816.1 1430790 D 585034 CDS YP_002386817.1 218553904 7126921 complement(1432292..1433227) 1 NC_011741.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1433227 ydaO 7126921 ydaO Escherichia coli IAI1 C32 tRNA thiolase YP_002386817.1 1432292 R 585034 CDS YP_002386818.1 218553905 7127852 complement(1433403..1433837) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 12381839, 11849540, 9298646; Product type f : factor; stress-induced protein, ATP-binding protein 1433837 uspF 7127852 uspF Escherichia coli IAI1 stress-induced protein, ATP-binding protein YP_002386818.1 1433403 R 585034 CDS YP_002386819.1 218553906 7125552 complement(1433978..1435111) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9642192; Product type t : transporter; outer membrane pore protein N, non-specific 1435111 ompN 7125552 ompN Escherichia coli IAI1 outer membrane pore protein N, non-specific YP_002386819.1 1433978 R 585034 CDS YP_002386820.1 218553907 7124273 complement(1435478..1439002) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9025293; Product type pe : putative enzyme; putative 2-oxoacid-flavodoxin fused oxidoreductase:conserved protein; 4Fe-4S cluster binding protein 1439002 ydbK 7124273 ydbK Escherichia coli IAI1 putative 2-oxoacid-flavodoxin fused oxidoreductase:conserved protein; 4Fe-4S cluster binding protein YP_002386820.1 1435478 R 585034 CDS YP_002386821.1 218553908 7127370 1439276..1439542 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1439542 ydbJ 7127370 ydbJ Escherichia coli IAI1 hypothetical protein YP_002386821.1 1439276 D 585034 CDS YP_002386822.1 218553909 7127288 complement(1439539..1439961) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12892888, 8349564, 9025293; Product type f : factor; heat-inducible protein 1439961 hslJ 7127288 hslJ Escherichia coli IAI1 heat-inducible protein YP_002386822.1 1439539 R 585034 CDS YP_002386823.1 218553910 7125312 complement(1440072..1441061) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4297266, 89123040, 90198524, 8349564, 9025293; Product type e : enzyme; fermentative D-lactate dehydrogenase 1441061 ldhA 7125312 ldhA Escherichia coli IAI1 fermentative D-lactate dehydrogenase YP_002386823.1 1440072 R 585034 CDS YP_002386824.1 218553911 7126399 1441269..1443908 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1443908 ydbH 7126399 ydbH Escherichia coli IAI1 hypothetical protein YP_002386824.1 1441269 D 585034 CDS YP_002386825.1 218553912 7127855 1443905..1444090 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 1444090 ynbE 7127855 ynbE Escherichia coli IAI1 hypothetical protein YP_002386825.1 1443905 D 585034 CDS YP_002386826.1 218553913 7127541 1444098..1444424 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1444424 ydbL 7127541 ydbL Escherichia coli IAI1 hypothetical protein YP_002386826.1 1444098 D 585034 CDS YP_002386827.1 218553914 7127371 complement(1444596..1445501) 1 NC_011741.1 activator of genes involved in phenylacetic acid catabolism; DNA-binding transcriptional activator FeaR 1445501 feaR 7127371 feaR Escherichia coli IAI1 DNA-binding transcriptional activator FeaR YP_002386827.1 1444596 R 585034 CDS YP_002386828.1 218553915 7127084 1445737..1447236 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96213037, 97263463, 9043126; Product type e : enzyme; phenylacetaldehyde dehydrogenase 1447236 feaB 7127084 feaB Escherichia coli IAI1 phenylacetaldehyde dehydrogenase YP_002386828.1 1445737 D 585034 CDS YP_002386829.1 218553916 7127083 complement(1447294..1449567) 1 NC_011741.1 catalyzes the formation of phenylacetaldehyde from 2-phenylethylamine; tyramine oxidase 1449567 tynA 7127083 tynA Escherichia coli IAI1 tyramine oxidase YP_002386829.1 1447294 R 585034 CDS YP_002386830.1 218553917 7127524 complement(1449815..1451860) 1 NC_011741.1 catalyzes the ring cleavage reaction in phenylacetate degradation and the formation of 3-hydroxyacyl-CoA from crotonyl-CoA; bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase 1451860 maoC 7127524 maoC Escherichia coli IAI1 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase YP_002386830.1 1449815 R 585034 CDS YP_002386831.1 218553918 7127671 1452145..1453074 1 NC_011741.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; phenylacetate-CoA oxygenase subunit PaaA 1453074 paaA 7127671 paaA Escherichia coli IAI1 phenylacetate-CoA oxygenase subunit PaaA YP_002386831.1 1452145 D 585034 CDS YP_002386832.1 218553919 7126004 1453086..1453373 1 NC_011741.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; involved in phenylacetate degradation; phenylacetate-CoA oxygenase subunit PaaB 1453373 paaB 7126004 paaB Escherichia coli IAI1 phenylacetate-CoA oxygenase subunit PaaB YP_002386832.1 1453086 D 585034 CDS YP_002386833.1 218553920 7126005 1453382..1454128 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12846838, 9748275; Product type pe : putative enzyme; putative multicomponent oxygenase/reductase subunit for phenylacetic acid degradation 1454128 paaC 7126005 paaC Escherichia coli IAI1 putative multicomponent oxygenase/reductase subunit for phenylacetic acid degradation YP_002386833.1 1453382 D 585034 CDS YP_002386834.1 218553921 7126006 1454143..1454640 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12846838, 9748275; Product type pe : putative enzyme; putative multicomponent oxygenase/reductase subunit for phenylacetic acid degradation 1454640 paaD 7126006 paaD Escherichia coli IAI1 putative multicomponent oxygenase/reductase subunit for phenylacetic acid degradation YP_002386834.1 1454143 D 585034 CDS YP_002386835.1 218553922 7126007 1454648..1455718 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17259607, 11260461, 12846838, 9748275; Product type e : enzyme; subunit of the phenylacetly-CoA oxygenase/reductase 1455718 paaJ 7126007 paaJ Escherichia coli IAI1 subunit of the phenylacetly-CoA oxygenase/reductase YP_002386835.1 1454648 D 585034 CDS YP_002386836.1 218553923 7126013 1455715..1456482 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12846838, 9748275, 10766858; Product type e : enzyme; enoyl-CoA hydratase-isomerase 1456482 paaF 7126013 paaF Escherichia coli IAI1 enoyl-CoA hydratase-isomerase YP_002386836.1 1455715 D 585034 CDS YP_002386837.1 218553924 7126009 1456482..1457270 1 NC_011741.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1457270 paaG 7126009 paaG Escherichia coli IAI1 enoyl-CoA hydratase YP_002386837.1 1456482 D 585034 CDS YP_002386838.1 218553925 7126010 1457272..1458699 1 NC_011741.1 converts 3-hydroxyadipyl-CoA to beta-ketoadipyl-CoA in phenylacetate degradation; 3-hydroxy-acyl-CoA dehydrogenase 1458699 paaH 7126010 paaH Escherichia coli IAI1 3-hydroxy-acyl-CoA dehydrogenase YP_002386838.1 1457272 D 585034 CDS YP_002386839.1 218553926 7126011 1458689..1459111 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16464851, 12846838, 9748275; Product type e : enzyme; phenylacetate pathway hotdog-fold thioesterase 1459111 paaI 7126011 paaI Escherichia coli IAI1 phenylacetate pathway hotdog-fold thioesterase YP_002386839.1 1458689 D 585034 CDS YP_002386840.1 218553927 7126012 1459111..1460316 1 NC_011741.1 catalyzes the thiolytic cleavage of beta-ketoadipyl-CoA to succinate and acetyl-CoA; beta-ketoadipyl CoA thiolase 1460316 paaE 7126012 paaE Escherichia coli IAI1 beta-ketoadipyl CoA thiolase YP_002386840.1 1459111 D 585034 CDS YP_002386841.1 218553928 7126008 1460343..1461656 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12846838, 9748275, 10766858; Product type e : enzyme; phenylacetyl-CoA ligase 1461656 paaK 7126008 paaK Escherichia coli IAI1 phenylacetyl-CoA ligase YP_002386841.1 1460343 D 585034 CDS YP_002386842.1 218553929 7126014 1461757..1462707 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12846838, 20229831, 9748275; Product type r : regulator; DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive 1462707 paaX 7126014 paaX Escherichia coli IAI1 DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive YP_002386842.1 1461757 D 585034 CDS YP_002386843.1 218553930 7126015 1462689..1463279 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12846838, 9748275; Product type pe : putative enzyme; putative hexapeptide repeat acetyltransferase 1463279 paaY 7126015 paaY Escherichia coli IAI1 putative hexapeptide repeat acetyltransferase YP_002386843.1 1462689 D 585034 CDS YP_002386844.1 218553931 7126016 1463511..1464371 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1464371 ydbC 7126016 ydbC Escherichia coli IAI1 putative oxidoreductase YP_002386844.1 1463511 D 585034 CDS YP_002386845.1 218553932 7127853 1464435..1466741 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1466741 ydbD 7127853 ydbD Escherichia coli IAI1 hypothetical protein YP_002386845.1 1464435 D 585034 CDS YP_002386846.1 218553933 7127854 1466912..1467517 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1467517 ynbA 7127854 ynbA Escherichia coli IAI1 hypothetical protein YP_002386846.1 1466912 D 585034 CDS YP_002386847.1 218553934 7127537 1467517..1468413 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane associated CTP-phosphosubstrate transferase 1468413 ynbB 7127537 ynbB Escherichia coli IAI1 putative membrane associated CTP-phosphosubstrate transferase YP_002386847.1 1467517 D 585034 CDS YP_002386848.1 218553935 7127538 1468429..1470186 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 1470186 ynbC 7127538 ynbC Escherichia coli IAI1 putative hydrolase YP_002386848.1 1468429 D 585034 CDS YP_002386849.1 218553936 7127539 1470200..1471492 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane associated phosphatase 1471492 ynbD 7127539 ynbD Escherichia coli IAI1 putative membrane associated phosphatase YP_002386849.1 1470200 D 585034 CDS YP_002386850.1 218553937 7127540 complement(1471543..1472148) 1 NC_011741.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase 1472148 azoR 7127540 azoR Escherichia coli IAI1 azoreductase YP_002386850.1 1471543 R 585034 CDS YP_002386851.1 218553938 7126284 1472406..1476251 1 NC_011741.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1476251 hrpA 7126284 hrpA Escherichia coli IAI1 ATP-dependent RNA helicase HrpA YP_002386851.1 1472406 D 585034 CDS YP_002386852.1 218553939 7125307 1476523..1477323 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1477323 ydcF 7125307 ydcF Escherichia coli IAI1 hypothetical protein YP_002386852.1 1476523 D 585034 CDS YP_002386853.1 218553940 7127374 1477520..1478959 1 NC_011741.1 NAD-linked; aldehyde dehydrogenase A 1478959 aldA 7127374 aldA Escherichia coli IAI1 aldehyde dehydrogenase A YP_002386853.1 1477520 D 585034 CDS YP_002386854.1 218553941 7125741 complement(1479001..1480002) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9622357, 9019141, 1917845, 3780374; Product type e : enzyme; glyceraldehyde-3-phosphate dehydrogenase C 1480002 gapC 7125741 gapC Escherichia coli IAI1 glyceraldehyde-3-phosphate dehydrogenase C YP_002386854.1 1479001 R 585034 CDS YP_002386855.1 218553942 7128278 1480191..1480721 1 NC_011741.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 1480721 cybB 7128278 cybB Escherichia coli IAI1 cytochrome b561 YP_002386855.1 1480191 D 585034 CDS YP_002386856.1 218553943 7124652 1480966..1481139 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1481139 ydcA 7124652 ydcA Escherichia coli IAI1 hypothetical protein YP_002386856.1 1480966 D 585034 CDS YP_002386857.1 218553944 7127372 complement(1481251..1481418) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type r : regulator; regulatory peptide 1481418 mokB 7127372 mokB Escherichia coli IAI1 regulatory peptide YP_002386857.1 1481251 R 585034 CDS YP_002386858.1 218553945 7127946 1481759..1483399 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90008892, 92390356, 93259131, 6374654; Product type r : regulator; methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor 1483399 trg 7127946 trg Escherichia coli IAI1 methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor YP_002386858.1 1481759 D 585034 CDS YP_002386859.1 218553946 7127484 complement(1483437..1484360) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1484360 ydcI 7127484 ydcI Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002386859.1 1483437 R 585034 CDS YP_002386860.1 218553947 7127376 1484577..1485920 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1485920 ydcJ 7127376 ydcJ Escherichia coli IAI1 hypothetical protein YP_002386860.1 1484577 D 585034 CDS YP_002386861.1 218553948 7127377 1486175..1487800 1 NC_011741.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 1487800 mdoD 7127377 mdoD Escherichia coli IAI1 glucan biosynthesis protein D YP_002386861.1 1486175 D 585034 CDS YP_002386862.1 218553949 7127685 complement(1487721..1487924) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 1487924 7127685 ECIAI1_1420 Escherichia coli IAI1 hypothetical protein YP_002386862.1 1487721 R 585034 CDS YP_002386863.1 218553950 7128661 1487940..1488164 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1488164 ydcH 7128661 ydcH Escherichia coli IAI1 hypothetical protein YP_002386863.1 1487940 D 585034 CDS YP_002386864.1 218553951 7127375 1488212..1488763 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89364711; Product type e : enzyme; ribosomal-protein-L7/L12-serine acetyltransferase 1488763 rimL 7127375 rimL Escherichia coli IAI1 ribosomal-protein-L7/L12-serine acetyltransferase YP_002386864.1 1488212 D 585034 CDS YP_002386865.1 218553952 7125004 complement(1488758..1489738) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 1489738 ydcK 7125004 ydcK Escherichia coli IAI1 hypothetical protein YP_002386865.1 1488758 R 585034 CDS YP_002386866.1 218553953 7127378 1489862..1490854 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94222856, 2060788; Product type t : transporter; potassium-tellurite ethidium and proflavin transporter 1490854 tehA 7127378 tehA Escherichia coli IAI1 potassium-tellurite ethidium and proflavin transporter YP_002386866.1 1489862 D 585034 CDS YP_002386867.1 218553954 7126234 1490851..1491444 1 NC_011741.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 1491444 tehB 7126234 tehB Escherichia coli IAI1 tellurite resistance protein TehB YP_002386867.1 1490851 D 585034 CDS YP_002386868.1 218553955 7126235 1491747..1492415 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 1492415 ydcL 7126235 ydcL Escherichia coli IAI1 hypothetical protein YP_002386868.1 1491747 D 585034 CDS YP_002386869.1 218553956 7127379 complement(1492433..1492600) 1 NC_011741.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; putative transposase ORF A (fragment), IS605 family 1492600 7127379 ECIAI1_1427 Escherichia coli IAI1 putative transposase ORF A (fragment), IS605 family YP_002386869.1 1492433 R 585034 CDS YP_002386870.1 218553957 7128662 complement(1492652..1492939) 1 NC_011741.1 Evidence 7 : Gene remnant; hypothetical protein 1492939 yncK 7128662 yncK Escherichia coli IAI1 hypothetical protein YP_002386870.1 1492652 R 585034 CDS YP_002386871.1 218553958 7127550 1492947..1494155 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase 1494155 ydcM 7127550 ydcM Escherichia coli IAI1 putative transposase YP_002386871.1 1492947 D 585034 CDS YP_002386872.1 218553959 7127380 complement(1494195..1495370) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1885518; Product type pt : putative transporter; putative benzoate transporter 1495370 ydcO 7127380 ydcO Escherichia coli IAI1 putative benzoate transporter YP_002386872.1 1494195 R 585034 CDS YP_002386873.1 218553960 7127384 1495462..1495998 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1495998 ydcN 7127384 ydcN Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002386873.1 1495462 D 585034 CDS YP_002386874.1 218553961 7127383 1496071..1498032 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 1498032 ydcP 7127383 ydcP Escherichia coli IAI1 putative peptidase YP_002386874.1 1496071 D 585034 CDS YP_002386875.1 218553962 7127385 complement(1498124..1498354) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1498354 yncJ 7127385 yncJ Escherichia coli IAI1 hypothetical protein YP_002386875.1 1498124 R 585034 CDS YP_002386876.1 218553963 7127549 1498755..1499192 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1499192 ydcQ 7127549 ydcQ Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002386876.1 1498755 D 585034 CDS YP_002386877.1 218553964 7127386 1499271..1500677 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15223311; Product type pr : putative regulator; putative DNA-binding transcriptional regulator fused with a domain with PLP-binding motif 1500677 ydcR 7127386 ydcR Escherichia coli IAI1 putative DNA-binding transcriptional regulator fused with a domain with PLP-binding motif YP_002386877.1 1499271 D 585034 CDS YP_002386878.1 218553965 7127387 1500922..1502067 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11683869; Product type pt : putative transporter; putative spermidine/putrescine ABC transporter periplasmic-binding protein 1502067 ydcS 7127387 ydcS Escherichia coli IAI1 putative spermidine/putrescine ABC transporter periplasmic-binding protein YP_002386878.1 1500922 D 585034 CDS YP_002386879.1 218553966 7127388 1502085..1503098 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative spermidine/putrescine ABC transporter ATP-binding protein 1503098 ydcT 7127388 ydcT Escherichia coli IAI1 putative spermidine/putrescine ABC transporter ATP-binding protein YP_002386879.1 1502085 D 585034 CDS YP_002386880.1 218553967 7127389 1503099..1504040 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative spermidine/putrescine ABC transporter permease 1504040 ydcU 7127389 ydcU Escherichia coli IAI1 putative spermidine/putrescine ABC transporter permease YP_002386880.1 1503099 D 585034 CDS YP_002386881.1 218553968 7127390 1504030..1504824 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative spermidine/putrescine ABC transporter permease 1504824 ydcV 7127390 ydcV Escherichia coli IAI1 putative spermidine/putrescine ABC transporter permease YP_002386881.1 1504030 D 585034 CDS YP_002386882.1 218553969 7127391 1504846..1506270 1 NC_011741.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 1506270 ydcW 7127391 ydcW Escherichia coli IAI1 gamma-aminobutyraldehyde dehydrogenase YP_002386882.1 1504846 D 585034 CDS YP_002386883.1 218553970 7127392 1506480..1507289 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8257133, 11841212, 12771141; Product type pe : putative enzyme; putative acetyltransferase 1507289 7127392 ECIAI1_1441 Escherichia coli IAI1 putative acetyltransferase YP_002386883.1 1506480 D 585034 CDS YP_002386884.1 218553971 7128663 1507906..1508154 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1508154 ydcX 7128663 ydcX Escherichia coli IAI1 hypothetical protein YP_002386884.1 1507906 D 585034 CDS YP_002386885.1 218553972 7127393 1508240..1508473 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1508473 ydcY 7127393 ydcY Escherichia coli IAI1 hypothetical protein YP_002386885.1 1508240 D 585034 CDS YP_002386886.1 218553973 7127394 complement(1508474..1508923) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1508923 ydcZ 7127394 ydcZ Escherichia coli IAI1 hypothetical protein YP_002386886.1 1508474 R 585034 CDS YP_002386887.1 218553974 7127395 complement(1508920..1509672) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA N-acyltransferase 1509672 yncA 7127395 yncA Escherichia coli IAI1 putative acyl-CoA N-acyltransferase YP_002386887.1 1508920 R 585034 CDS YP_002386888.1 218553975 7127542 1509619..1510656 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative conserved oxidoreductase 1510656 yncB 7127542 yncB Escherichia coli IAI1 putative conserved oxidoreductase YP_002386888.1 1509619 D 585034 CDS YP_002386889.1 218553976 7127543 1510854..1511519 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11004173; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1511519 yncC 7127543 yncC Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002386889.1 1510854 D 585034 CDS YP_002386890.1 218553977 7127544 complement(1511555..1513657) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative iron outer membrane receptor 1513657 yncD 7127544 yncD Escherichia coli IAI1 putative iron outer membrane receptor YP_002386890.1 1511555 R 585034 CDS YP_002386891.1 218553978 7127545 1513899..1514960 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1514960 yncE 7127545 yncE Escherichia coli IAI1 hypothetical protein YP_002386891.1 1513899 D 585034 CDS YP_002386892.1 218553979 7127546 complement(1515075..1516574) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76005443; Product type t : transporter; L-asparagine transporter 1516574 ansP 7127546 ansP Escherichia coli IAI1 L-asparagine transporter YP_002386892.1 1515075 R 585034 CDS YP_002386893.1 218553980 7125766 1516841..1517458 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; glutathione S-transferase-like protein 1517458 yncG 7125766 yncG Escherichia coli IAI1 glutathione S-transferase-like protein YP_002386893.1 1516841 D 585034 CDS YP_002386894.1 218553981 7125569 1520742..1524950 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 98361897, 1766878, 2403547, 2644231, 7934896; Product type h : extrachromosomal origin; rhsD element protein 1524950 rhsD 7125569 rhsD Escherichia coli IAI1 rhsD element protein YP_002386894.1 1520742 D 585034 CDS YP_002386895.1 218553982 7124988 1524926..1525357 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9696756; hypothetical protein 1525357 7124988 ECIAI1_1456 Escherichia coli IAI1 hypothetical protein YP_002386895.1 1524926 D 585034 CDS YP_002386896.1 218553983 7128664 1525424..1525573 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1525573 7128664 ECIAI1_1457 Escherichia coli IAI1 hypothetical protein YP_002386896.1 1525424 D 585034 CDS YP_002386897.1 218553984 7127146 1526776..1527255 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1527255 7127146 ECIAI1_1459 Escherichia coli IAI1 hypothetical protein YP_002386897.1 1526776 D 585034 CDS YP_002386898.1 218553985 7128666 1527521..1527715 1 NC_011741.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1527715 7128666 ECIAI1_1460 Escherichia coli IAI1 hypothetical protein YP_002386898.1 1527521 D 585034 CDS YP_002386899.1 218553986 7128667 1527790..1532058 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1766878, 2644231, 2403547, 7934896; putative protein rhsD 1532058 7128667 ECIAI1_1461 Escherichia coli IAI1 putative protein rhsD YP_002386899.1 1527790 D 585034 CDS YP_002386900.1 218553987 7128668 1532058..1532519 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9696756; hypothetical protein 1532519 7128668 ECIAI1_1462 Escherichia coli IAI1 hypothetical protein YP_002386900.1 1532058 D 585034 CDS YP_002386901.1 218553988 7127147 1533538..1533831 1 NC_011741.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 1533831 7127147 ECIAI1_1464 Escherichia coli IAI1 4-oxalocrotonate tautomerase YP_002386901.1 1533538 D 585034 CDS YP_002386902.1 218553989 7128670 complement(1533835..1534404) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1534404 yddH 7128670 yddH Escherichia coli IAI1 hypothetical protein YP_002386902.1 1533835 R 585034 CDS YP_002386903.1 218553990 7127400 1534577..1535422 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20267568; Product type e : enzyme; N-hydroxyarylamine O-acetyltransferase 1535422 nhoA 7127400 nhoA Escherichia coli IAI1 N-hydroxyarylamine O-acetyltransferase YP_002386903.1 1534577 D 585034 CDS YP_002386904.1 218553991 7127876 complement(1535518..1536411) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14611652, 15103639, 2233673; hypothetical protein 1536411 yddE 7127876 yddE Escherichia coli IAI1 hypothetical protein YP_002386904.1 1535518 R 585034 CDS YP_002386905.1 218553992 7127398 complement(1536491..1537171) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type e : enzyme; nitrate reductase 2 subunit gamma 1537171 narV 7127398 narV Escherichia coli IAI1 nitrate reductase 2 subunit gamma YP_002386905.1 1536491 R 585034 CDS YP_002386906.1 218553993 7127858 complement(1537168..1537863) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410, 92186712; Product type f : factor; nitrate reductase 2 subunit delta (assembly subunit) 1537863 narW 7127858 narW Escherichia coli IAI1 nitrate reductase 2 subunit delta (assembly subunit) YP_002386906.1 1537168 R 585034 CDS YP_002386907.1 218553994 7127859 complement(1537863..1539407) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type c : carrier; nitrate reductase 2 subunit beta 1539407 narY 7127859 narY Escherichia coli IAI1 nitrate reductase 2 subunit beta YP_002386907.1 1537863 R 585034 CDS YP_002386908.1 218553995 7127861 complement(1539404..1543144) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type e : enzyme; nitrate reductase 2 subunit alpha 1543144 narZ 7127861 narZ Escherichia coli IAI1 nitrate reductase 2 subunit alpha YP_002386908.1 1539404 R 585034 CDS YP_002386909.1 218553996 7127862 complement(1543226..1544614) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95266795, 2233673; Product type t : transporter; nitrate/nitrite transporter 1544614 narU 7127862 narU Escherichia coli IAI1 nitrate/nitrite transporter YP_002386909.1 1543226 R 585034 CDS YP_002386910.1 218553997 7127857 complement(1544938..1546269) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1546269 7127857 ECIAI1_1474 Escherichia coli IAI1 hypothetical protein YP_002386910.1 1544938 R 585034 CDS YP_002386911.1 218553998 7128671 complement(1546293..1546583) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7926834; Product type m : membrane component; outer membrane porin 1546583 yddL 7128671 yddL Escherichia coli IAI1 outer membrane porin YP_002386911.1 1546293 R 585034 CDS YP_002386912.1 218553999 7127401 complement(1546842..1547666) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12410826; Product type t : transporter; hypothetical protein 1547666 yddG 7127401 yddG Escherichia coli IAI1 hypothetical protein YP_002386912.1 1546842 R 585034 CDS YP_002386913.1 218554000 7127399 1547955..1551002 1 NC_011741.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-N subunit alpha 1551002 fdnG 7127399 fdnG Escherichia coli IAI1 formate dehydrogenase-N subunit alpha YP_002386913.1 1547955 D 585034 CDS YP_002386914.1 218554001 7127075 1551015..1551899 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76005553, 90375017, 92332427, 11884747, 1834669; Product type c : carrier; formate dehydrogenase-N, Fe-S subunit beta 1551899 fdnH 7127075 fdnH Escherichia coli IAI1 formate dehydrogenase-N, Fe-S subunit beta YP_002386914.1 1551015 D 585034 CDS YP_002386915.1 218554002 7127076 1551892..1552545 1 NC_011741.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma 1552545 fdnI 7127076 fdnI Escherichia coli IAI1 formate dehydrogenase-N subunit gamma YP_002386915.1 1551892 D 585034 CDS YP_002386916.1 218554003 7127077 complement(1552596..1552958) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1552958 yddM 7127077 yddM Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002386916.1 1552596 R 585034 CDS YP_002386917.1 218554004 7127402 complement(1553027..1554037) 1 NC_011741.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 1554037 adhP 7127402 adhP Escherichia coli IAI1 alcohol dehydrogenase YP_002386917.1 1553027 R 585034 CDS YP_002386918.1 218554005 7125718 complement(1554171..1555868) 1 NC_011741.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 1555868 sfcA 7125718 sfcA Escherichia coli IAI1 malate dehydrogenase YP_002386918.1 1554171 R 585034 CDS YP_002386919.1 218554006 7127915 complement(1556264..1556479) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10498711, 13129944; Product type f : factor; biofilm-dependent modulation protein 1556479 bdm 7127915 bdm Escherichia coli IAI1 biofilm-dependent modulation protein YP_002386919.1 1556264 R 585034 CDS YP_002386920.1 218554007 7124393 1556824..1557255 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14512736, 91350191, 9298646; Product type m : membrane component; osmotically inducible, stress-inducible membrane protein 1557255 osmC 7124393 osmC Escherichia coli IAI1 osmotically inducible, stress-inducible membrane protein YP_002386920.1 1556824 D 585034 CDS YP_002386921.1 218554008 7125996 complement(1557290..1558060) 1 NC_011741.1 catalyzes the formation of acetoacetate from 3-hydroxybutyrate; 3-hydroxybutyrate dehydrogenase 1558060 7125996 ECIAI1_1486 Escherichia coli IAI1 3-hydroxybutyrate dehydrogenase YP_002386921.1 1557290 R 585034 CDS YP_002386922.1 218554009 7128672 complement(1558072..1559463) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1559463 7128672 ECIAI1_1487 Escherichia coli IAI1 hypothetical protein YP_002386922.1 1558072 R 585034 CDS YP_002386923.1 218554010 7128673 complement(1559509..1560432) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 3-hydroxyacyl-CoA dehydrogenase 1560432 7128673 ECIAI1_1488 Escherichia coli IAI1 putative 3-hydroxyacyl-CoA dehydrogenase YP_002386923.1 1559509 R 585034 CDS YP_002386924.1 218554011 7128674 complement(1560422..1561627) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyl-CoA acetyltransferase 1561627 7128674 ECIAI1_1489 Escherichia coli IAI1 putative acetyl-CoA acetyltransferase YP_002386924.1 1560422 R 585034 CDS YP_002386925.1 218554012 7128675 complement(1561637..1562293) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9385134; Product type e : enzyme; succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B 1562293 scoB 7128675 scoB Escherichia coli IAI1 succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B YP_002386925.1 1561637 R 585034 CDS YP_002386926.1 218554013 7124682 complement(1562296..1563003) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9385134; Product type e : enzyme; succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A 1563003 scoA 7124682 scoA Escherichia coli IAI1 succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A YP_002386926.1 1562296 R 585034 CDS YP_002386927.1 218554014 7124681 1563145..1564035 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type r : regulator; putative transcriptional regulator 1564035 7124681 ECIAI1_1492 Escherichia coli IAI1 putative transcriptional regulator YP_002386927.1 1563145 D 585034 CDS YP_002386928.1 218554015 7128676 complement(1564072..1564998) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-ala ABC transporter ATP-binding protein 1564998 ddpF 7128676 ddpF Escherichia coli IAI1 D-ala-D-ala ABC transporter ATP-binding protein YP_002386928.1 1564072 R 585034 CDS YP_002386929.1 218554016 7124554 complement(1564991..1565977) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-ala ABC transporter ATP-binding protein 1565977 ddpD 7124554 ddpD Escherichia coli IAI1 D-ala-D-ala ABC transporter ATP-binding protein YP_002386929.1 1564991 R 585034 CDS YP_002386930.1 218554017 7124553 complement(1565974..1566870) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; ATP-dependent peptide transporter membrane subunit 1566870 ddpC 7124553 ddpC Escherichia coli IAI1 ATP-dependent peptide transporter membrane subunit YP_002386930.1 1565974 R 585034 CDS YP_002386931.1 218554018 7124552 complement(1566867..1567889) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-ala ABC transporter membrane protein 1567889 ddpB 7124552 ddpB Escherichia coli IAI1 D-ala-D-ala ABC transporter membrane protein YP_002386931.1 1566867 R 585034 CDS YP_002386932.1 218554019 7124551 complement(1567891..1569441) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-a la ABC transporter periplasmic-binding protein 1569441 ddpA 7124551 ddpA Escherichia coli IAI1 D-ala-D-a la ABC transporter periplasmic-binding protein YP_002386932.1 1567891 R 585034 CDS YP_002386933.1 218554020 7124550 complement(1569455..1570036) 1 NC_011741.1 catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis; D-alanyl-D-alanine dipeptidase 1570036 ddpX 7124550 ddpX Escherichia coli IAI1 D-alanyl-D-alanine dipeptidase YP_002386933.1 1569455 R 585034 CDS YP_002386934.1 218554021 7124555 complement(1570294..1572693) 1 NC_011741.1 heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate; cAMP phosphodiesterase 1572693 dos 7124555 dos Escherichia coli IAI1 cAMP phosphodiesterase YP_002386934.1 1570294 R 585034 CDS YP_002386935.1 218554022 7124615 complement(1572718..1574100) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16497924, 15142243; Product type pe : putative enzyme; putative diguanylate cyclase 1574100 yddV 7124615 yddV Escherichia coli IAI1 putative diguanylate cyclase YP_002386935.1 1572718 R 585034 CDS YP_002386936.1 218554023 7127403 complement(1574472..1575791) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10960106; Product type lp : lipoprotein; hypothetical protein 1575791 yddW 7127403 yddW Escherichia coli IAI1 hypothetical protein YP_002386936.1 1574472 R 585034 CDS YP_002386937.1 218554024 7127404 complement(1575922..1577457) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15795232, 15489450; Product type t : transporter; glutamate:gamma-aminobutyric acid antiporter 1577457 gadC 7127404 gadC Escherichia coli IAI1 glutamate:gamma-aminobutyric acid antiporter YP_002386937.1 1575922 R 585034 CDS YP_002386938.1 218554025 7128263 complement(1577613..1579013) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12912902, 92155241, 92394884, 99406302, 8455549; Product type e : enzyme; glutamate decarboxylase B, PLP-dependent 1579013 gadB 7128263 gadB Escherichia coli IAI1 glutamate decarboxylase B, PLP-dependent YP_002386938.1 1577613 R 585034 CDS YP_002386939.1 218554026 7128262 complement(1579375..1582170) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1659611, 11514505; Product type pe : putative enzyme; putative membrane-associated peptidase 1582170 pqqL 7128262 pqqL Escherichia coli IAI1 putative membrane-associated peptidase YP_002386939.1 1579375 R 585034 CDS YP_002386940.1 218554027 7126142 complement(1582215..1584587) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative porin protein 1584587 yddB 7126142 yddB Escherichia coli IAI1 putative porin protein YP_002386940.1 1582215 R 585034 CDS YP_002386941.1 218554028 7127397 complement(1584625..1586310) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative multidrug transporter fused subunits of ABC superfamily transporter: permease; ATP-binding component 1586310 yddA 7127397 yddA Escherichia coli IAI1 putative multidrug transporter fused subunits of ABC superfamily transporter: permease; ATP-binding component YP_002386941.1 1584625 R 585034 CDS YP_002386942.1 218554029 7127396 complement(1586601..1587758) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pr : putative regulator; hypothetical protein 1587758 ydeM 7127396 ydeM Escherichia coli IAI1 hypothetical protein YP_002386942.1 1586601 R 585034 CDS YP_002386943.1 218554030 7127410 complement(1587810..1589492) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sulfatase 1589492 ydeN 7127410 ydeN Escherichia coli IAI1 putative sulfatase YP_002386943.1 1587810 R 585034 CDS YP_002386944.1 218554031 7127411 complement(1589894..1590655) 1 NC_011741.1 regulates the cellular response to acid resistance; transcriptional regulator YdeO 1590655 ydeO 7127411 ydeO Escherichia coli IAI1 transcriptional regulator YdeO YP_002386944.1 1589894 R 585034 CDS YP_002386945.1 218554032 7127412 complement(1590730..1590927) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1590927 7127412 ECIAI1_1510 Escherichia coli IAI1 hypothetical protein YP_002386945.1 1590730 R 585034 CDS YP_002386946.1 218554033 7128677 complement(1591175..1593454) 1 NC_011741.1 in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase family; putative oxidoreductase 1593454 ydeP 7128677 ydeP Escherichia coli IAI1 putative oxidoreductase YP_002386946.1 1591175 R 585034 CDS YP_002386947.1 218554034 7127413 complement(1593788..1594702) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like exported adhesin protein 1594702 ydeQ 7127413 ydeQ Escherichia coli IAI1 putative fimbrial-like exported adhesin protein YP_002386947.1 1593788 R 585034 CDS YP_002386948.1 218554035 7127414 complement(1594762..1595265) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein 1595265 ydeR 7127414 ydeR Escherichia coli IAI1 putative fimbrial-like adhesin exported protein YP_002386948.1 1594762 R 585034 CDS YP_002386949.1 218554036 7127415 complement(1595278..1595808) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein 1595808 ydeS 7127415 ydeS Escherichia coli IAI1 putative fimbrial-like adhesin exported protein YP_002386949.1 1595278 R 585034 CDS YP_002386950.1 218554037 7127416 complement(1595822..1598473) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative fimbrial outer membrane usher protein 1598473 7127416 ECIAI1_1515 Escherichia coli IAI1 putative fimbrial outer membrane usher protein YP_002386950.1 1595822 R 585034 CDS YP_002386951.1 218554038 7128678 complement(1598515..1599234) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; Periplasmic chaperone 1599234 7128678 ECIAI1_1516 Escherichia coli IAI1 Periplasmic chaperone YP_002386951.1 1598515 R 585034 CDS YP_002386952.1 218554039 7128679 1599445..1599591 1 NC_011741.1 hypothetical protein 1599591 7128679 ECIAI1_1517 Escherichia coli IAI1 hypothetical protein YP_002386952.1 1599445 D 585034 CDS YP_002386953.1 218554040 7128680 complement(1599586..1600197) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative major fimbrial subunit FmlA 1600197 7128680 ECIAI1_1518 Escherichia coli IAI1 putative major fimbrial subunit FmlA YP_002386953.1 1599586 R 585034 CDS YP_002386954.1 218554041 7128681 complement(1600606..1600785) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 1600785 yneL 7128681 yneL Escherichia coli IAI1 putative transcriptional regulator YP_002386954.1 1600606 R 585034 CDS YP_002386955.1 218554042 7127560 complement(1601102..1602424) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358364, 94292428, 15576765; Product type r : regulator; regulator with hipB 1602424 hipA 7127560 hipA Escherichia coli IAI1 regulator with hipB YP_002386955.1 1601102 R 585034 CDS YP_002386956.1 218554043 7128526 complement(1602424..1602690) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358364, 94292428, 15576765, 8021189; Product type r : regulator; DNA-binding transcriptional regulator HipB 1602690 hipB 7128526 hipB Escherichia coli IAI1 DNA-binding transcriptional regulator HipB YP_002386956.1 1602424 R 585034 CDS YP_002386957.1 218554044 7125188 complement(1602899..1608319) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative lipoprotein/autotransporter domain-containing protein 1608319 7125188 ECIAI1_1522 Escherichia coli IAI1 putative lipoprotein/autotransporter domain-containing protein YP_002386957.1 1602899 R 585034 CDS YP_002386958.1 218554045 7128682 complement(1608850..1610442) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15601708, 14622426; Product type e : enzyme; autoinducer-2 (AI-2) kinase 1610442 lsrK 7128682 lsrK Escherichia coli IAI1 autoinducer-2 (AI-2) kinase YP_002386958.1 1608850 R 585034 CDS YP_002386959.1 218554046 7127638 complement(1610521..1611474) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16321939, 15601708, 14622426; Product type r : regulator; DNA-binding transcriptional regulator 1611474 lsrR 7127638 lsrR Escherichia coli IAI1 DNA-binding transcriptional regulator YP_002386959.1 1610521 R 585034 CDS YP_002386960.1 218554047 7127639 1611723..1613258 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12657059, 11722742; Product type t : transporter; AI2 ABC transporter ATP-binding protein 1613258 ego 7127639 ego Escherichia coli IAI1 AI2 ABC transporter ATP-binding protein YP_002386960.1 1611723 D 585034 CDS YP_002386961.1 218554048 7125054 1613252..1614280 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11722742; Product type t : transporter; AI2 ABC transporter membrane protein 1614280 lsrC 7125054 lsrC Escherichia coli IAI1 AI2 ABC transporter membrane protein YP_002386961.1 1613252 D 585034 CDS YP_002386962.1 218554049 7127634 1614280..1615272 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11722742; Product type t : transporter; AI2 ABC transporter membrane protein 1615272 lsrD 7127634 lsrD Escherichia coli IAI1 AI2 ABC transporter membrane protein YP_002386962.1 1614280 D 585034 CDS YP_002386963.1 218554050 7127635 1615284..1616306 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11722742; Product type t : transporter; AI2 ABC transporter periplasmic-binding protein 1616306 lsrB 7127635 lsrB Escherichia coli IAI1 AI2 ABC transporter periplasmic-binding protein YP_002386963.1 1615284 D 585034 CDS YP_002386964.1 218554051 7127633 1616333..1617208 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; aldolase 1617208 lsrF 7127633 lsrF Escherichia coli IAI1 aldolase YP_002386964.1 1616333 D 585034 CDS YP_002386965.1 218554052 7127636 1617232..1617522 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; autoinducer-2 (AI-2) modifying protein LsrG 1617522 lsrG 7127636 lsrG Escherichia coli IAI1 autoinducer-2 (AI-2) modifying protein LsrG YP_002386965.1 1617232 D 585034 CDS YP_002386966.1 218554053 7127637 1617579..1618337 1 NC_011741.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 1618337 tam 7127637 tam Escherichia coli IAI1 trans-aconitate 2-methyltransferase YP_002386966.1 1617579 D 585034 CDS YP_002386967.1 218554054 7126210 complement(1618341..1619255) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1619255 yneE 7126210 yneE Escherichia coli IAI1 hypothetical protein YP_002386967.1 1618341 R 585034 CDS YP_002386968.1 218554055 7127552 complement(1619462..1620913) 1 NC_011741.1 catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase 1620913 uxaB 7127552 uxaB Escherichia coli IAI1 altronate oxidoreductase YP_002386968.1 1619462 R 585034 CDS YP_002386969.1 218554056 7125561 complement(1621140..1622558) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated diguanylate cyclase 1622558 yneF 7125561 yneF Escherichia coli IAI1 putative membrane-associated diguanylate cyclase YP_002386969.1 1621140 R 585034 CDS YP_002386970.1 218554057 7127553 complement(1622697..1623056) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1623056 yneG 7127553 yneG Escherichia coli IAI1 hypothetical protein YP_002386970.1 1622697 R 585034 CDS YP_002386971.1 218554058 7127554 complement(1623056..1623982) 1 NC_011741.1 catalyzes the formation of glutamate from glutamine; glutaminase 1623982 yneH 7127554 yneH Escherichia coli IAI1 glutaminase YP_002386971.1 1623056 R 585034 CDS YP_002386972.1 218554059 7127555 complement(1624046..1625434) 1 NC_011741.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; putative succinate semialdehyde dehydrogenase 1625434 yneI 7127555 yneI Escherichia coli IAI1 putative succinate semialdehyde dehydrogenase YP_002386972.1 1624046 R 585034 CDS YP_002386973.1 218554060 7127556 1625535..1626416 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1626416 yneJ 7127556 yneJ Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002386973.1 1625535 D 585034 CDS YP_002386974.1 218554061 7127559 1627758..1628948 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10094697, 99369894, 8383113, 10438792; Product type t : transporter; sugar efflux transporter 1628948 ydeA 7127559 ydeA Escherichia coli IAI1 sugar efflux transporter YP_002386974.1 1627758 D 585034 CDS YP_002386975.1 218554062 7127405 complement(1628973..1629638) 1 NC_011741.1 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC 1629638 marC 7127405 marC Escherichia coli IAI1 multiple drug resistance protein MarC YP_002386975.1 1628973 R 585034 CDS YP_002386976.1 218554063 7127675 1629850..1630284 1 NC_011741.1 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; DNA-binding transcriptional repressor MarR 1630284 marR 7127675 marR Escherichia coli IAI1 DNA-binding transcriptional repressor MarR YP_002386976.1 1629850 D 585034 CDS YP_002386977.1 218554064 7127676 1630304..1630687 1 NC_011741.1 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; DNA-binding transcriptional activator MarA 1630687 marA 7127676 marA Escherichia coli IAI1 DNA-binding transcriptional activator MarA YP_002386977.1 1630304 D 585034 CDS YP_002386978.1 218554065 7127673 1630719..1630937 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8383113; hypothetical protein 1630937 marB 7127673 marB Escherichia coli IAI1 hypothetical protein YP_002386978.1 1630719 D 585034 CDS YP_002386979.1 218554066 7127674 complement(1630994..1632439) 1 NC_011741.1 converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase 1632439 celA 7127674 celA Escherichia coli IAI1 6-phospho-beta-glucosidase YP_002386979.1 1630994 R 585034 CDS YP_002386980.1 218554067 7128683 complement(1632458..1634131) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative carbohydrate-specific outer membrane porin 1634131 7128683 ECIAI1_1547 Escherichia coli IAI1 putative carbohydrate-specific outer membrane porin YP_002386980.1 1632458 R 585034 CDS YP_002386981.1 218554068 7128684 complement(1634187..1634501) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system PTS, lactose/cellobiose-specific IIA subunit 1634501 7128684 ECIAI1_1548 Escherichia coli IAI1 putative phosphotransferase system PTS, lactose/cellobiose-specific IIA subunit YP_002386981.1 1634187 R 585034 CDS YP_002386982.1 218554069 7128685 complement(1634526..1635887) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system IIC component 1635887 7128685 ECIAI1_1549 Escherichia coli IAI1 putative phosphotransferase system IIC component YP_002386982.1 1634526 R 585034 CDS YP_002386983.1 218554070 7128686 complement(1635963..1636274) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cellobiose-specific phosphotransferase enzyme IIB component 1636274 7128686 ECIAI1_1550 Escherichia coli IAI1 putative cellobiose-specific phosphotransferase enzyme IIB component YP_002386983.1 1635963 R 585034 CDS YP_002386984.1 218554071 7128687 1636473..1637171 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator HTH family 1637171 7128687 ECIAI1_1551 Escherichia coli IAI1 putative DNA-binding transcriptional regulator HTH family YP_002386984.1 1636473 D 585034 CDS YP_002386985.1 218554072 7128688 complement(1637216..1638115) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20305052; Product type t : transporter; O-acetylserine/cysteine export protein 1638115 eamA 7128688 eamA Escherichia coli IAI1 O-acetylserine/cysteine export protein YP_002386985.1 1637216 R 585034 CDS YP_002386986.1 218554073 7125039 1638310..1639497 1 NC_011741.1 YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters; putative MFS-type transporter YdeE 1639497 ydeE 7125039 ydeE Escherichia coli IAI1 putative MFS-type transporter YdeE YP_002386986.1 1638310 D 585034 CDS YP_002386987.1 218554074 7127406 complement(1639938..1640828) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1640828 ydeH 7127406 ydeH Escherichia coli IAI1 hypothetical protein YP_002386987.1 1639938 R 585034 CDS YP_002386988.1 218554075 7127407 complement(1641083..1641475) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1641475 ydeI 7127407 ydeI Escherichia coli IAI1 hypothetical protein YP_002386988.1 1641083 R 585034 CDS YP_002386989.1 218554076 7127408 1641751..1642269 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A 1642269 ydeJ 7127408 ydeJ Escherichia coli IAI1 competence damage-inducible protein A YP_002386989.1 1641751 D 585034 CDS YP_002386990.1 218554077 7127409 complement(1642314..1644359) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 216006, 8226676; Product type e : enzyme; dipeptidyl carboxypeptidase II 1644359 dcp 7127409 dcp Escherichia coli IAI1 dipeptidyl carboxypeptidase II YP_002386990.1 1642314 R 585034 CDS YP_002386991.1 218554078 7126924 1644496..1645242 1 NC_011741.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase 1645242 ydfG 7126924 ydfG Escherichia coli IAI1 3-hydroxy acid dehydrogenase YP_002386991.1 1644496 D 585034 CDS YP_002386992.1 218554079 7127421 1645331..1646017 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1646017 ydfH 7127421 ydfH Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002386992.1 1645331 D 585034 CDS YP_002386993.1 218554080 7127422 1646195..1646398 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12084818; Product type pc : putative carrier; putative selenium carrying protein 1646398 ydfZ 7127422 ydfZ Escherichia coli IAI1 putative selenium carrying protein YP_002386993.1 1646195 D 585034 CDS YP_002386994.1 218554081 7127432 complement(1646434..1647894) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative mannonate dehydrogenase 1647894 ydfI 7127432 ydfI Escherichia coli IAI1 putative mannonate dehydrogenase YP_002386994.1 1646434 R 585034 CDS YP_002386995.1 218554082 7127423 complement(1647983..1649266) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 1649266 ydfJ 7127423 ydfJ Escherichia coli IAI1 putative transporter YP_002386995.1 1647983 R 585034 CDS YP_002386996.1 218554083 7127424 1650019..1650285 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1650285 ydfK 7127424 ydfK Escherichia coli IAI1 hypothetical protein YP_002386996.1 1650019 D 585034 CDS YP_002386997.1 218554084 7127425 1650602..1651192 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14687564; Product type pe : putative enzyme; putative site-specific recombinase; DNA invertase; Rac prophage 1651192 pinR 7127425 pinR Escherichia coli IAI1 putative site-specific recombinase; DNA invertase; Rac prophage YP_002386997.1 1650602 D 585034 CDS YP_002386998.1 218554085 7124225 complement(1651290..1651865) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative tail fiber chaperone; Qin prophage 1651865 tfaQ 7124225 tfaQ Escherichia coli IAI1 putative tail fiber chaperone; Qin prophage YP_002386998.1 1651290 R 585034 CDS YP_002386999.1 218554086 7126238 complement(1651865..1654831) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber protein 1654831 7126238 ECIAI1_1566 Escherichia coli IAI1 putative tail fiber protein YP_002386999.1 1651865 R 585034 CDS YP_002387000.1 218554087 7128689 1653324..1654328 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1654328 7128689 ECIAI1_1567 Escherichia coli IAI1 hypothetical protein YP_002387000.1 1653324 D 585034 CDS YP_002387001.1 218554088 7128690 1654716..1654889 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1654889 7128690 ECIAI1_1568 Escherichia coli IAI1 hypothetical protein YP_002387001.1 1654716 D 585034 CDS YP_002387002.1 218554089 7128691 complement(1654890..1655489) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Lom-like outer membrane protein of phage origin 1655489 7128691 ECIAI1_1569 Escherichia coli IAI1 putative Lom-like outer membrane protein of phage origin YP_002387002.1 1654890 R 585034 CDS YP_002387003.1 218554090 7128692 complement(1655560..1659057) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J of prophage 1659057 7128692 ECIAI1_1570 Escherichia coli IAI1 Host specificity protein J of prophage YP_002387003.1 1655560 R 585034 CDS YP_002387004.1 218554091 7128693 complement(1659118..1659789) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Tail assembly protein I 1659789 7128693 ECIAI1_1571 Escherichia coli IAI1 Tail assembly protein I YP_002387004.1 1659118 R 585034 CDS YP_002387005.1 218554092 7128694 complement(1659687..1660430) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber component K of prophage 1660430 7128694 ECIAI1_1572 Escherichia coli IAI1 putative tail fiber component K of prophage YP_002387005.1 1659687 R 585034 CDS YP_002387006.1 218554093 7128696 complement(1661135..1661464) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein M 1661464 7128696 ECIAI1_1574 Escherichia coli IAI1 Minor tail protein M YP_002387006.1 1661135 R 585034 CDS YP_002387007.1 218554094 7128697 complement(1661461..1664040) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein H 1664040 7128697 ECIAI1_1575 Escherichia coli IAI1 Minor tail protein H YP_002387007.1 1661461 R 585034 CDS YP_002387008.1 218554095 7128698 complement(1664033..1664467) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein T 1664467 7128698 ECIAI1_1576 Escherichia coli IAI1 Minor tail protein T YP_002387008.1 1664033 R 585034 CDS YP_002387009.1 218554096 7128699 complement(1664449..1664871) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein G 1664871 7128699 ECIAI1_1577 Escherichia coli IAI1 Minor tail protein G YP_002387009.1 1664449 R 585034 CDS YP_002387010.1 218554097 7128700 complement(1664887..1665657) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major tail protein V 1665657 7128700 ECIAI1_1578 Escherichia coli IAI1 Major tail protein V YP_002387010.1 1664887 R 585034 CDS YP_002387011.1 218554098 7128701 complement(1665635..1666030) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein U 1666030 7128701 ECIAI1_1579 Escherichia coli IAI1 Minor tail protein U YP_002387011.1 1665635 R 585034 CDS YP_002387012.1 218554099 7125590 complement(1666027..1666605) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein Z (GpZ) 1666605 7125590 ECIAI1_1580 Escherichia coli IAI1 Minor tail protein Z (GpZ) YP_002387012.1 1666027 R 585034 CDS YP_002387013.1 218554100 7126769 complement(1666617..1666970) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin; Tail attachment protein (Minor capsid protein FII) from bacteriophage origin 1666970 fII 7126769 fII Escherichia coli IAI1 Tail attachment protein (Minor capsid protein FII) from bacteriophage origin YP_002387013.1 1666617 R 585034 CDS YP_002387014.1 218554101 7127109 complement(1666982..1667416) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; DNA packaging protein from bacteriophage origin 1667416 fI 7127109 fI Escherichia coli IAI1 DNA packaging protein from bacteriophage origin YP_002387014.1 1666982 R 585034 CDS YP_002387015.1 218554102 7127105 complement(1667419..1668471) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Major head coat protein from bacteriophage origin 1668471 E 7127105 E Escherichia coli IAI1 Major head coat protein from bacteriophage origin YP_002387015.1 1667419 R 585034 CDS YP_002387016.1 218554103 7125038 complement(1668500..1668838) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Head decoration protein from bacteriophage origin 1668838 D 7125038 D Escherichia coli IAI1 Head decoration protein from bacteriophage origin YP_002387016.1 1668500 R 585034 CDS YP_002387017.1 218554104 7126907 complement(1668842..1670296) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin; Minor capsid protein C from bacteriophage origin 1670296 C 7126907 C Escherichia coli IAI1 Minor capsid protein C from bacteriophage origin YP_002387017.1 1668842 R 585034 CDS YP_002387018.1 218554105 7124430 complement(1670142..1671743) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Portal protein; minor capsid protein 1671743 B 7124430 B Escherichia coli IAI1 Portal protein; minor capsid protein YP_002387018.1 1670142 R 585034 CDS YP_002387019.1 218554106 7126286 complement(1671740..1671946) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11302702; Product type h : extrachromosomal origin; Head-to-tail joining protein W (gpW) from bacteriophage origin 1671946 W 7126286 W Escherichia coli IAI1 Head-to-tail joining protein W (gpW) from bacteriophage origin YP_002387019.1 1671740 R 585034 CDS YP_002387020.1 218554107 7125573 complement(1671943..1673868) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Terminase large subunit from bacteriophage origin 1673868 A 7125573 A Escherichia coli IAI1 Terminase large subunit from bacteriophage origin YP_002387020.1 1671943 R 585034 CDS YP_002387021.1 218554108 7125674 complement(1673843..1674388) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92334985; Product type h : extrachromosomal origin; DNA packaging protein; DLP12 prophage 1674388 nohB 7125674 nohB Escherichia coli IAI1 DNA packaging protein; DLP12 prophage YP_002387021.1 1673843 R 585034 CDS YP_002387022.1 218554109 7127895 complement(1674528..1674671) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1674671 7127895 ECIAI1_1590 Escherichia coli IAI1 hypothetical protein YP_002387022.1 1674528 R 585034 CDS YP_002387023.1 218554110 7126770 1674777..1675010 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1675010 ynfO 7126770 ynfO Escherichia coli IAI1 hypothetical protein YP_002387023.1 1674777 D 585034 CDS YP_002387024.1 218554111 7127573 1675068..1675478 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1675478 ydfO 7127573 ydfO Escherichia coli IAI1 hypothetical protein YP_002387024.1 1675068 D 585034 CDS YP_002387025.1 218554112 7127426 complement(1675630..1675803) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21429224; Product type h : extrachromosomal origin; hypothetical protein 1675803 gnsB 7127426 gnsB Escherichia coli IAI1 hypothetical protein YP_002387025.1 1675630 R 585034 CDS YP_002387026.1 218554113 7128368 complement(1675975..1676247) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1676247 7128368 ECIAI1_1594 Escherichia coli IAI1 hypothetical protein YP_002387026.1 1675975 R 585034 CDS YP_002387027.1 218554114 7126771 complement(1676477..1676689) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9484881; Product type h : extrachromosomal origin; cold shock protein; Qin prophage 1676689 cspI 7126771 cspI Escherichia coli IAI1 cold shock protein; Qin prophage YP_002387027.1 1676477 R 585034 CDS YP_002387028.1 218554115 7126851 complement(1677053..1677550) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1677550 ydfP 7126851 ydfP Escherichia coli IAI1 hypothetical protein YP_002387028.1 1677053 R 585034 CDS YP_002387029.1 218554116 7127427 complement(1677547..1678080) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated lysozyme; Qin prophage 1678080 ydfQ 7127427 ydfQ Escherichia coli IAI1 putative membrane-associated lysozyme; Qin prophage YP_002387029.1 1677547 R 585034 CDS YP_002387030.1 218554117 7127428 complement(1678077..1678388) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1678388 ydfR 7127428 ydfR Escherichia coli IAI1 hypothetical protein YP_002387030.1 1678077 R 585034 CDS YP_002387031.1 218554118 7127429 complement(1678393..1678608) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative S lysis protein; Qin prophage 1678608 essQ 7127429 essQ Escherichia coli IAI1 putative S lysis protein; Qin prophage YP_002387031.1 1678393 R 585034 CDS YP_002387032.1 218554119 7125091 complement(1679362..1679577) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293754, 94293756, 9439003; Product type h : extrachromosomal origin; cold shock protein; Qin prophage 1679577 cspB 7125091 cspB Escherichia coli IAI1 cold shock protein; Qin prophage YP_002387032.1 1679362 R 585034 CDS YP_002387033.1 218554120 7125932 1679878..1680090 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9484881, 8022261, 9439003; Product type h : extrachromosomal origin; cold shock protein; Qin prophage 1680090 cspF 7125932 cspF Escherichia coli IAI1 cold shock protein; Qin prophage YP_002387033.1 1679878 D 585034 CDS YP_002387034.1 218554121 7125936 complement(1680512..1681264) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative antitermination protein Q; Qin prophage 1681264 ydfT 7125936 ydfT Escherichia coli IAI1 putative antitermination protein Q; Qin prophage YP_002387034.1 1680512 R 585034 CDS YP_002387035.1 218554122 7127430 complement(1681278..1682327) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1682327 ydfU 7127430 ydfU Escherichia coli IAI1 hypothetical protein YP_002387035.1 1681278 R 585034 CDS YP_002387036.1 218554123 7127431 complement(1682674..1682925) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2990907; Product type h : extrachromosomal origin; hypothetical protein 1682925 rem 7127431 rem Escherichia coli IAI1 hypothetical protein YP_002387036.1 1682674 R 585034 CDS YP_002387037.1 218554124 7124960 complement(1683369..1683656) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21592958, 99141390, 2990907; Product type h : extrachromosomal origin; toxin of the RelE-RelB toxin-antitoxin system; Qin prophage 1683656 relE 7124960 relE Escherichia coli IAI1 toxin of the RelE-RelB toxin-antitoxin system; Qin prophage YP_002387037.1 1683369 R 585034 CDS YP_002387038.1 218554125 7124959 complement(1683656..1683895) 1 NC_011741.1 Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor; bifunctional antitoxin/transcriptional repressor RelB 1683895 relB 7124959 relB Escherichia coli IAI1 bifunctional antitoxin/transcriptional repressor RelB YP_002387038.1 1683656 R 585034 CDS YP_002387039.1 218554126 7124958 complement(1683926..1684087) 1 NC_011741.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1684087 7124958 ECIAI1_1607 Escherichia coli IAI1 hypothetical protein YP_002387039.1 1683926 R 585034 CDS YP_002387040.1 218554127 7126772 1684428..1684760 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9358034; Product type h : extrachromosomal origin; hypothetical protein 1684760 flxA 7126772 flxA Escherichia coli IAI1 hypothetical protein YP_002387040.1 1684428 D 585034 CDS YP_002387041.1 218554128 7126774 1686716..1686898 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1686898 7126774 ECIAI1_1611 Escherichia coli IAI1 hypothetical protein YP_002387041.1 1686716 D 585034 CDS YP_002387042.1 218554129 7126775 complement(1687657..1687782) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1687782 7126775 ECIAI1_1612 Escherichia coli IAI1 hypothetical protein YP_002387042.1 1687657 R 585034 CDS YP_002387043.1 218554130 7126776 complement(1687832..1687942) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1687942 7126776 ECIAI1_1613 Escherichia coli IAI1 hypothetical protein YP_002387043.1 1687832 R 585034 CDS YP_002387044.1 218554131 7126777 complement(1688205..1688561) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1688561 7126777 ECIAI1_1614 Escherichia coli IAI1 hypothetical protein YP_002387044.1 1688205 R 585034 CDS YP_002387045.1 218554132 7126778 complement(1688558..1688980) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1688980 7126778 ECIAI1_1615 Escherichia coli IAI1 hypothetical protein YP_002387045.1 1688558 R 585034 CDS YP_002387046.1 218554133 7126779 complement(1689021..1690040) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1690040 7126779 ECIAI1_1616 Escherichia coli IAI1 hypothetical protein YP_002387046.1 1689021 R 585034 CDS YP_002387047.1 218554134 7126780 complement(1689967..1690488) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1690488 7126780 ECIAI1_1617 Escherichia coli IAI1 hypothetical protein YP_002387047.1 1689967 R 585034 CDS YP_002387048.1 218554135 7126781 complement(1690472..1690702) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88232418, 3532030; Product type h : extrachromosomal origin; DNA-binding transcriptional regulator DicC 1690702 dicC 7126781 dicC Escherichia coli IAI1 DNA-binding transcriptional regulator DicC YP_002387048.1 1690472 R 585034 CDS YP_002387049.1 218554136 7124584 1690786..1691193 1 NC_011741.1 The transcriptional repressor of DicA (divison cell) has a hypothetical DNA binding domain. It represses the transcription of dicB and dicC, but its specific role in cellular replication and mode of action are still unknown.; transcriptional repressor DicA 1691193 dicA 7124584 dicA Escherichia coli IAI1 transcriptional repressor DicA YP_002387049.1 1690786 D 585034 CDS YP_002387050.1 218554137 7124583 1691282..1691515 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1691515 ydfA 7124583 ydfA Escherichia coli IAI1 hypothetical protein YP_002387050.1 1691282 D 585034 CDS YP_002387051.1 218554138 7127417 1691517..1691645 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1691645 ydfB 7127417 ydfB Escherichia coli IAI1 hypothetical protein YP_002387051.1 1691517 D 585034 CDS YP_002387052.1 218554139 7127418 1691675..1691893 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1691893 ydfC 7127418 ydfC Escherichia coli IAI1 hypothetical protein YP_002387052.1 1691675 D 585034 CDS YP_002387053.1 218554140 7127419 complement(1691897..1692112) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 1692112 7127419 ECIAI1_1623 Escherichia coli IAI1 hypothetical protein YP_002387053.1 1691897 R 585034 CDS YP_002387054.1 218554141 7124585 1692346..1692639 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative regulator of cell division encoded by prophage 1692639 7124585 ECIAI1_1624 Escherichia coli IAI1 putative regulator of cell division encoded by prophage YP_002387054.1 1692346 D 585034 CDS YP_002387055.1 218554142 7126783 1692636..1692827 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1692827 ydfD 7126783 ydfD Escherichia coli IAI1 hypothetical protein YP_002387055.1 1692636 D 585034 CDS YP_002387056.1 218554143 7127420 1692884..1695391 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative exonuclease from phage origin 1695391 7127420 ECIAI1_1626 Escherichia coli IAI1 putative exonuclease from phage origin YP_002387056.1 1692884 D 585034 CDS YP_002387057.1 218554144 7126784 1695464..1695715 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; prophage excisionase 1695715 xis 7126784 xis Escherichia coli IAI1 prophage excisionase YP_002387057.1 1695464 D 585034 CDS YP_002387058.1 218554145 7126473 1695735..1697030 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative defective integrase; Qin prophage 1697030 intQ 7126473 intQ Escherichia coli IAI1 putative defective integrase; Qin prophage YP_002387058.1 1695735 D 585034 CDS YP_002387059.1 218554146 7126073 complement(1697032..1697160) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1697160 7126073 ECIAI1_1629 Escherichia coli IAI1 hypothetical protein YP_002387059.1 1697032 R 585034 CDS YP_002387060.1 218554147 7126785 complement(1697218..1698237) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7545940; Product type pe : putative enzyme; putative dehydrogenase 1698237 rspB 7126785 rspB Escherichia coli IAI1 putative dehydrogenase YP_002387060.1 1697218 R 585034 CDS YP_002387061.1 218554148 7128441 complement(1698249..1699463) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 93341455, 94310441; Product type pe : putative enzyme; putative enolase/dehydratase 1699463 rspA 7128441 rspA Escherichia coli IAI1 putative enolase/dehydratase YP_002387061.1 1698249 R 585034 CDS YP_002387062.1 218554149 7128439 complement(1699669..1699995) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1699995 ynfA 7128439 ynfA Escherichia coli IAI1 hypothetical protein YP_002387062.1 1699669 R 585034 CDS YP_002387063.1 218554150 7127561 1700130..1700471 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1700471 ynfB 7127561 ynfB Escherichia coli IAI1 hypothetical protein YP_002387063.1 1700130 D 585034 CDS YP_002387064.1 218554151 7127562 1700506..1701066 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94357898; Product type e : enzyme; spermidine N1-acetyltransferase 1701066 speG 7127562 speG Escherichia coli IAI1 spermidine N1-acetyltransferase YP_002387064.1 1700506 D 585034 CDS YP_002387065.1 218554152 7127960 complement(1701069..1701779) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1701779 ynfC 7127960 ynfC Escherichia coli IAI1 hypothetical protein YP_002387065.1 1701069 R 585034 CDS YP_002387066.1 218554153 7127563 1701887..1702192 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9868784; hypothetical protein 1702192 ynfD 7127563 ynfD Escherichia coli IAI1 hypothetical protein YP_002387066.1 1701887 D 585034 CDS YP_002387067.1 218554154 7127564 1702391..1704817 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type e : enzyme; oxidoreductase subunit 1704817 ynfE 7127564 ynfE Escherichia coli IAI1 oxidoreductase subunit YP_002387067.1 1702391 D 585034 CDS YP_002387068.1 218554155 7127565 1704878..1707301 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type e : enzyme; oxidoreductase subunit 1707301 ynfF 7127565 ynfF Escherichia coli IAI1 oxidoreductase subunit YP_002387068.1 1704878 D 585034 CDS YP_002387069.1 218554156 7127566 1707312..1707929 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type c : carrier; oxidoreductase, Fe-S subunit 1707929 ynfG 7127566 ynfG Escherichia coli IAI1 oxidoreductase, Fe-S subunit YP_002387069.1 1707312 D 585034 CDS YP_002387070.1 218554157 7127567 1707931..1708785 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type m : membrane component; oxidoreductase, membrane subunit 1708785 ynfH 7127567 ynfH Escherichia coli IAI1 oxidoreductase, membrane subunit YP_002387070.1 1707931 D 585034 CDS YP_002387071.1 218554158 7127568 1708828..1709442 1 NC_011741.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1709442 dmsD 7127568 dmsD Escherichia coli IAI1 twin-argninine leader-binding protein DmsD YP_002387071.1 1708828 D 585034 CDS YP_002387072.1 218554159 7124603 1709638..1710894 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12384697; Product type pt : putative transporter; putative voltage-gated ClC-type chloride channel ClcB 1710894 clcB 7124603 clcB Escherichia coli IAI1 putative voltage-gated ClC-type chloride channel ClcB YP_002387072.1 1709638 D 585034 CDS YP_002387073.1 218554160 7126330 complement(1710847..1711542) 1 NC_011741.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; putative dithiobiotin synthetase 1711542 ynfK 7126330 ynfK Escherichia coli IAI1 putative dithiobiotin synthetase YP_002387073.1 1710847 R 585034 CDS YP_002387074.1 218554161 7127569 complement(1711667..1712887) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10318813, 20490366, 6989798, 99340206, 99395104, 99398866, 7766024; Product type r : regulator; DNA-binding transcriptional repressor 1712887 dgsA 7127569 dgsA Escherichia coli IAI1 DNA-binding transcriptional repressor YP_002387074.1 1711667 R 585034 CDS YP_002387075.1 218554162 7124577 complement(1713022..1713915) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1713915 ynfL 7124577 ynfL Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002387075.1 1713022 R 585034 CDS YP_002387076.1 218554163 7127570 1714022..1715275 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1715275 ynfM 7127570 ynfM Escherichia coli IAI1 putative MFS superfamily transporter YP_002387076.1 1714022 D 585034 CDS YP_002387077.1 218554164 7127571 1715699..1716007 1 NC_011741.1 required for growth and survival under moderately acid conditions; acid shock protein 1716007 asr 7127571 asr Escherichia coli IAI1 acid shock protein YP_002387077.1 1715699 D 585034 CDS YP_002387078.1 218554165 7126268 1716283..1717104 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported metallopeptidase 1717104 ydgD 7126268 ydgD Escherichia coli IAI1 putative exported metallopeptidase YP_002387078.1 1716283 D 585034 CDS YP_002387079.1 218554166 7127435 complement(1717143..1717472) 1 NC_011741.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI 1717472 mdtI 7127435 mdtI Escherichia coli IAI1 multidrug efflux system protein MdtI YP_002387079.1 1717143 R 585034 CDS YP_002387080.1 218554167 7124228 complement(1717459..1717824) 1 NC_011741.1 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ 1717824 mdtJ 7124228 mdtJ Escherichia coli IAI1 multidrug efflux system protein MdtJ YP_002387080.1 1717459 R 585034 CDS YP_002387081.1 218554168 7124229 1718236..1719270 1 NC_011741.1 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; putative transport protein 1719270 tqsA 7124229 tqsA Escherichia coli IAI1 putative transport protein YP_002387081.1 1718236 D 585034 CDS YP_002387082.1 218554169 7127436 complement(1719295..1720683) 1 NC_011741.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 1720683 pntB 7127436 pntB Escherichia coli IAI1 pyridine nucleotide transhydrogenase YP_002387082.1 1719295 R 585034 CDS YP_002387083.1 218554170 7126109 complement(1720694..1722226) 1 NC_011741.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 1722226 pntA 7126109 pntA Escherichia coli IAI1 NAD(P) transhydrogenase subunit alpha YP_002387083.1 1720694 R 585034 CDS YP_002387084.1 218554171 7126108 1722750..1723694 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1723694 ydgH 7126108 ydgH Escherichia coli IAI1 hypothetical protein YP_002387084.1 1722750 D 585034 CDS YP_002387085.1 218554172 7127437 1723880..1725262 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1311296; Product type pt : putative transporter; putative arginine/ornithine antiporter transporter 1725262 ydgI 7127437 ydgI Escherichia coli IAI1 putative arginine/ornithine antiporter transporter YP_002387085.1 1723880 D 585034 CDS YP_002387086.1 218554173 7127438 1725299..1726021 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14617668; Product type e : enzyme; short chain dehydrogenase 1726021 folM 7127438 folM Escherichia coli IAI1 short chain dehydrogenase YP_002387086.1 1725299 D 585034 CDS YP_002387087.1 218554174 7127265 complement(1726018..1726353) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1726353 ydgC 7127265 ydgC Escherichia coli IAI1 hypothetical protein YP_002387087.1 1726018 R 585034 CDS YP_002387088.1 218554175 7127434 1726473..1727201 1 NC_011741.1 response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 1727201 rstA 7127434 rstA Escherichia coli IAI1 DNA-binding transcriptional regulator RstA YP_002387088.1 1726473 D 585034 CDS YP_002387089.1 218554176 7128444 1727205..1728506 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93086426, 1495392, 1925016, 2646639; Product type r : regulator; sensor protein RstB 1728506 rstB 7128444 rstB Escherichia coli IAI1 sensor protein RstB YP_002387089.1 1727205 D 585034 CDS YP_002387090.1 218554177 7128445 1728582..1729511 1 NC_011741.1 binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 1729511 tus 7128445 tus Escherichia coli IAI1 DNA replication terminus site-binding protein YP_002387090.1 1728582 D 585034 CDS YP_002387091.1 218554178 7127518 complement(1729508..1730911) 1 NC_011741.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1730911 fumC 7127518 fumC Escherichia coli IAI1 fumarate hydratase YP_002387091.1 1729508 R 585034 CDS YP_002387092.1 218554179 7128254 complement(1731054..1732700) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88193096, 88268900, 92011457, 3005475, 6328431, 9298646; Product type e : enzyme; fumarate hydratase 1732700 fumA 7128254 fumA Escherichia coli IAI1 fumarate hydratase YP_002387092.1 1731054 R 585034 CDS YP_002387093.1 218554180 7128252 1732899..1734074 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82100097, 6397402; Product type e : enzyme; mannose-6-phosphate isomerase 1734074 manA 7128252 manA Escherichia coli IAI1 mannose-6-phosphate isomerase YP_002387093.1 1732899 D 585034 CDS YP_002387094.1 218554181 7127667 1734175..1735683 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1735683 ydgA 7127667 ydgA Escherichia coli IAI1 hypothetical protein YP_002387094.1 1734175 D 585034 CDS YP_002387095.1 218554182 7127433 complement(1735728..1736993) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15774881; Product type t : transporter; putative outer membrane porin protein 1736993 uidC 7127433 uidC Escherichia coli IAI1 putative outer membrane porin protein YP_002387095.1 1735728 R 585034 CDS YP_002387096.1 218554183 7125533 complement(1737032..1738405) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3534890; Product type t : transporter; glucuronide transporter 1738405 uidB 7125533 uidB Escherichia coli IAI1 glucuronide transporter YP_002387096.1 1737032 R 585034 CDS YP_002387097.1 218554184 7125532 complement(1738402..1740213) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87041472, 88038341, 2103475, 8125312; Product type e : enzyme; beta-D-glucuronidase 1740213 uidA 7125532 uidA Escherichia coli IAI1 beta-D-glucuronidase YP_002387097.1 1738402 R 585034 CDS YP_002387098.1 218554185 7125531 complement(1740601..1741191) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88038341, 2823062, 3934044, 11115104; Product type r : regulator; DNA-binding transcriptional repressor 1741191 uidR 7125531 uidR Escherichia coli IAI1 DNA-binding transcriptional repressor YP_002387098.1 1740601 R 585034 CDS YP_002387099.1 218554186 7125534 complement(1741420..1742187) 1 NC_011741.1 Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase 1742187 hdhA 7125534 hdhA Escherichia coli IAI1 7-alpha-hydroxysteroid dehydrogenase YP_002387099.1 1741420 R 585034 CDS YP_002387100.1 218554187 7128503 complement(1742299..1743327) 1 NC_011741.1 regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI 1743327 malI 7128503 malI Escherichia coli IAI1 DNA-binding transcriptional repressor MalI YP_002387100.1 1742299 R 585034 CDS YP_002387101.1 218554188 7127657 1743502..1745094 1 NC_011741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional PTS system maltose and glucose-specific transporter subunits IICB 1745094 malX 7127657 malX Escherichia coli IAI1 bifunctional PTS system maltose and glucose-specific transporter subunits IICB YP_002387101.1 1743502 D 585034 CDS YP_002387102.1 218554189 7127664 1745104..1746276 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20164451, 7665481, 91310596; Product type e : enzyme; bifunctional beta-cystathionase, PLP-dependent and regulator of maltose regulon 1746276 malY 7127664 malY Escherichia coli IAI1 bifunctional beta-cystathionase, PLP-dependent and regulator of maltose regulon YP_002387102.1 1745104 D 585034 CDS YP_002387103.1 218554190 7127665 1746380..1747381 1 NC_011741.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 1747381 add 7127665 add Escherichia coli IAI1 adenosine deaminase YP_002387103.1 1746380 D 585034 CDS YP_002387104.1 218554191 7125715 complement(1747416..1748456) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1748456 ydgJ 7125715 ydgJ Escherichia coli IAI1 putative oxidoreductase YP_002387104.1 1747416 R 585034 CDS YP_002387105.1 218554192 7127439 1748624..1748824 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20392465, 10931331; Product type m : membrane component; beta-lactam resistance membrane protein 1748824 blr 7127439 blr Escherichia coli IAI1 beta-lactam resistance membrane protein YP_002387105.1 1748624 D 585034 CDS YP_002387106.1 218554193 7124417 1749097..1749312 1 NC_011741.1 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein 1749312 ydgT 7124417 ydgT Escherichia coli IAI1 oriC-binding nucleoid-associated protein YP_002387106.1 1749097 D 585034 CDS YP_002387107.1 218554194 7127442 1749398..1749838 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1749838 ydgK 7127442 ydgK Escherichia coli IAI1 hypothetical protein YP_002387107.1 1749398 D 585034 CDS YP_002387108.1 218554195 7127440 1749915..1750496 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411911, 10637328, 12773378; Product type pm : putative membrane component; Na(+)-translocating NADH-quinone reductase subunit E 1750496 rsxA 7127440 rsxA Escherichia coli IAI1 Na(+)-translocating NADH-quinone reductase subunit E YP_002387108.1 1749915 D 585034 CDS YP_002387109.1 218554196 7128447 1750496..1751074 1 NC_011741.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 1751074 rsxB 7128447 rsxB Escherichia coli IAI1 electron transport complex protein RnfB YP_002387109.1 1750496 D 585034 CDS YP_002387110.1 218554197 7128448 1751067..1753193 1 NC_011741.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 1753193 rsxC 7128448 rsxC Escherichia coli IAI1 electron transport complex protein RnfC YP_002387110.1 1751067 D 585034 CDS YP_002387111.1 218554198 7124544 1753194..1754252 1 NC_011741.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 1754252 rnfD 7124544 rnfD Escherichia coli IAI1 electron transport complex protein RnfD YP_002387111.1 1753194 D 585034 CDS YP_002387112.1 218554199 7124625 1754256..1754876 1 NC_011741.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 1754876 rsxG 7124625 rsxG Escherichia coli IAI1 electron transport complex protein RnfG YP_002387112.1 1754256 D 585034 CDS YP_002387113.1 218554200 7124627 1754880..1755575 1 NC_011741.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex RsxE subunit 1755575 rsxE 7124627 rsxE Escherichia coli IAI1 electron transport complex RsxE subunit YP_002387113.1 1754880 D 585034 CDS YP_002387114.1 218554201 7124626 1755575..1756210 1 NC_011741.1 DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III 1756210 nth 7124626 nth Escherichia coli IAI1 endonuclease III YP_002387114.1 1755575 D 585034 CDS YP_002387115.1 218554202 7125950 1756821..1758323 1 NC_011741.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; putative tripeptide transporter permease 1758323 tppB 7125950 tppB Escherichia coli IAI1 putative tripeptide transporter permease YP_002387115.1 1756821 D 585034 CDS YP_002387116.1 218554203 7127441 1758429..1759034 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95096109, 2185038, 9680481; Product type e : enzyme; glutathionine S-transferase 1759034 gst 7127441 gst Escherichia coli IAI1 glutathionine S-transferase YP_002387116.1 1758429 D 585034 CDS YP_002387117.1 218554204 7128475 complement(1759078..1759941) 1 NC_011741.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 1759941 pdxY 7128475 pdxY Escherichia coli IAI1 pyridoxamine kinase YP_002387117.1 1759078 R 585034 CDS YP_002387118.1 218554205 7124168 complement(1760000..1761274) 1 NC_011741.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1761274 tyrS 7124168 tyrS Escherichia coli IAI1 tyrosyl-tRNA synthetase YP_002387118.1 1760000 R 585034 CDS YP_002387119.1 218554206 7127529 complement(1761403..1762059) 1 NC_011741.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 1762059 pdxH 7127529 pdxH Escherichia coli IAI1 pyridoxamine 5'-phosphate oxidase YP_002387119.1 1761403 R 585034 CDS YP_002387120.1 218554207 7124165 complement(1762118..1762447) 1 NC_011741.1 MliC; membrane-bound lysozyme inhibitor of c-type lysozyme; lysozyme inhibitor 1762447 ydhA 7124165 ydhA Escherichia coli IAI1 lysozyme inhibitor YP_002387120.1 1762118 R 585034 CDS YP_002387121.1 218554208 7127443 complement(1762545..1763654) 1 NC_011741.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 1763654 anmK 7127443 anmK Escherichia coli IAI1 anhydro-N-acetylmuramic acid kinase YP_002387121.1 1762545 R 585034 CDS YP_002387122.1 218554209 7125763 1763928..1764395 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8544813; Product type lp : lipoprotein; putative outer membrane lipoprotein 1764395 slyB 7125763 slyB Escherichia coli IAI1 putative outer membrane lipoprotein YP_002387122.1 1763928 D 585034 CDS YP_002387123.1 218554210 7127933 complement(1764442..1764876) 1 NC_011741.1 Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA 1764876 slyA 7127933 slyA Escherichia coli IAI1 transcriptional regulator SlyA YP_002387123.1 1764442 R 585034 CDS YP_002387124.1 218554211 7127932 1765077..1765313 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1765313 ydhI 7127932 ydhI Escherichia coli IAI1 hypothetical protein YP_002387124.1 1765077 D 585034 CDS YP_002387125.1 218554212 7127448 1765316..1766173 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12900028; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase 1766173 ydhJ 7127448 ydhJ Escherichia coli IAI1 undecaprenyl pyrophosphate phosphatase YP_002387125.1 1765316 D 585034 CDS YP_002387126.1 218554213 7127449 1766173..1768185 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1768185 ydhK 7127449 ydhK Escherichia coli IAI1 hypothetical protein YP_002387126.1 1766173 D 585034 CDS YP_002387127.1 218554214 7127530 complement(1768186..1768707) 1 NC_011741.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase 1768707 sodC 7127530 sodC Escherichia coli IAI1 superoxide dismutase YP_002387127.1 1768186 R 585034 CDS YP_002387128.1 218554215 7127943 complement(1768788..1769684) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1769684 ydhF 7127943 ydhF Escherichia coli IAI1 putative oxidoreductase YP_002387128.1 1768788 R 585034 CDS YP_002387129.1 218554216 7127447 complement(1769733..1770143) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1770143 ydhL 7127447 ydhL Escherichia coli IAI1 hypothetical protein YP_002387129.1 1769733 R 585034 CDS YP_002387130.1 218554217 7127289 1770159..1770674 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1770674 ydhM 7127289 ydhM Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002387130.1 1770159 D 585034 CDS YP_002387131.1 218554218 7127290 1770711..1771808 1 NC_011741.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase 1771808 nemA 7127290 nemA Escherichia coli IAI1 N-ethylmaleimide reductase YP_002387131.1 1770711 D 585034 CDS YP_002387132.1 218554219 7127866 1771889..1772296 1 NC_011741.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 1772296 gloA 7127866 gloA Escherichia coli IAI1 glyoxalase I YP_002387132.1 1771889 D 585034 CDS YP_002387133.1 218554220 7128332 1772399..1773046 1 NC_011741.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 1773046 rnt 7128332 rnt Escherichia coli IAI1 ribonuclease T YP_002387133.1 1772399 D 585034 CDS YP_002387134.1 218554221 7128612 1773139..1777755 1 NC_011741.1 similar to the DNA and RNA helicase superfamily II and eukaryotic DEAD family of helicases; longest known protein in E. coli; putative ATP-dependent helicase Lhr 1777755 lhr 7128612 lhr Escherichia coli IAI1 putative ATP-dependent helicase Lhr YP_002387134.1 1773139 D 585034 CDS YP_002387135.1 218554222 7126417 complement(1777806..1778153) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15833738, 15840565, 11950925, 12730244; Product type e : enzyme; hypothetical protein 1778153 ydhD 7126417 ydhD Escherichia coli IAI1 hypothetical protein YP_002387135.1 1777806 R 585034 CDS YP_002387136.1 218554223 7127446 1778488..1779303 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported hydrolase 1779303 ydhO 7127446 ydhO Escherichia coli IAI1 putative exported hydrolase YP_002387136.1 1778488 D 585034 CDS YP_002387137.1 218554224 7127291 1779431..1780012 1 NC_011741.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 1780012 sodB 7127291 sodB Escherichia coli IAI1 superoxide dismutase YP_002387137.1 1779431 D 585034 CDS YP_002387138.1 218554225 7127942 complement(1780158..1781327) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative efflux protein; MFS family 1781327 ydhP 7127942 ydhP Escherichia coli IAI1 putative efflux protein; MFS family YP_002387138.1 1780158 R 585034 CDS YP_002387139.1 218554226 7127292 1781881..1782906 1 NC_011741.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 1782906 purR 7127292 purR Escherichia coli IAI1 DNA-binding transcriptional repressor PurR YP_002387139.1 1781881 D 585034 CDS YP_002387140.1 218554227 7126555 complement(1782903..1783835) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2404765; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1783835 ydhB 7126555 ydhB Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002387140.1 1782903 R 585034 CDS YP_002387141.1 218554228 7127444 1783948..1785159 1 NC_011741.1 uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 1785159 ydhC 7127444 ydhC Escherichia coli IAI1 inner membrane transport protein YdhC YP_002387141.1 1783948 D 585034 CDS YP_002387142.1 218554229 7127445 1785450..1786598 1 NC_011741.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane fatty acyl phospholipid synthase 1786598 cfa 7127445 cfa Escherichia coli IAI1 cyclopropane fatty acyl phospholipid synthase YP_002387142.1 1785450 D 585034 CDS YP_002387143.1 218554230 7126299 complement(1786638..1787279) 1 NC_011741.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1787279 ribC 7126299 ribC Escherichia coli IAI1 riboflavin synthase subunit alpha YP_002387143.1 1786638 R 585034 CDS YP_002387144.1 218554231 7124994 1787494..1788867 1 NC_011741.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1788867 mdtK 7124994 mdtK Escherichia coli IAI1 multidrug efflux protein YP_002387144.1 1787494 D 585034 CDS YP_002387145.1 218554232 7124230 complement(1788908..1790164) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1790164 ydhQ 7124230 ydhQ Escherichia coli IAI1 hypothetical protein YP_002387145.1 1788908 R 585034 CDS YP_002387146.1 218554233 7127990 1790737..1791042 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1791042 ydhR 7127990 ydhR Escherichia coli IAI1 hypothetical protein YP_002387146.1 1790737 D 585034 CDS YP_002387147.1 218554234 7127294 1791168..1792772 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1792772 ydhS 7127294 ydhS Escherichia coli IAI1 hypothetical protein YP_002387147.1 1791168 D 585034 CDS YP_002387148.1 218554235 7127295 complement(1792784..1793596) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1793596 ydhT 7127295 ydhT Escherichia coli IAI1 hypothetical protein YP_002387148.1 1792784 R 585034 CDS YP_002387149.1 218554236 7127296 complement(1793600..1794385) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative cytochrome b subunit of a reductase 1794385 ydhU 7127296 ydhU Escherichia coli IAI1 putative cytochrome b subunit of a reductase YP_002387149.1 1793600 R 585034 CDS YP_002387150.1 218554237 7127297 complement(1794382..1795050) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S ferridoxin-type subunit of oxidoreductase 1795050 ydhX 7127297 ydhX Escherichia coli IAI1 putative 4Fe-4S ferridoxin-type subunit of oxidoreductase YP_002387150.1 1794382 R 585034 CDS YP_002387151.1 218554238 7127300 complement(1795114..1795761) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1795761 ydhW 7127300 ydhW Escherichia coli IAI1 hypothetical protein YP_002387151.1 1795114 R 585034 CDS YP_002387152.1 218554239 7127299 complement(1795765..1797867) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1797867 ydhV 7127299 ydhV Escherichia coli IAI1 putative oxidoreductase YP_002387152.1 1795765 R 585034 CDS YP_002387153.1 218554240 7127298 complement(1797888..1798514) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; hypothetical protein 1798514 ydhY 7127298 ydhY Escherichia coli IAI1 hypothetical protein YP_002387153.1 1797888 R 585034 CDS YP_002387154.1 218554241 7127301 complement(1798970..1799179) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1799179 ydhZ 7127301 ydhZ Escherichia coli IAI1 hypothetical protein YP_002387154.1 1798970 R 585034 CDS YP_002387155.1 218554242 7127302 1799736..1801148 1 NC_011741.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1801148 pykF 7127302 pykF Escherichia coli IAI1 pyruvate kinase YP_002387155.1 1799736 D 585034 CDS YP_002387156.1 218554243 7126568 1801459..1801695 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 334727, 338599, 322142, 353292, 391404, 4261992, 4575979, 6765942; Product type lp : lipoprotein; murein lipoprotein 1801695 lpp 7126568 lpp Escherichia coli IAI1 murein lipoprotein YP_002387156.1 1801459 D 585034 CDS YP_002387157.1 218554244 7127619 complement(1801759..1802763) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1802763 ynhG 7127619 ynhG Escherichia coli IAI1 hypothetical protein YP_002387157.1 1801759 R 585034 CDS YP_002387158.1 218554245 7127574 complement(1802912..1803328) 1 NC_011741.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE 1803328 sufE 7127574 sufE Escherichia coli IAI1 cysteine desufuration protein SufE YP_002387158.1 1802912 R 585034 CDS YP_002387159.1 218554246 7126196 complement(1803341..1804561) 1 NC_011741.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase 1804561 sufS 7126196 sufS Escherichia coli IAI1 bifunctional cysteine desulfurase/selenocysteine lyase YP_002387159.1 1803341 R 585034 CDS YP_002387160.1 218554247 7126198 complement(1804558..1805829) 1 NC_011741.1 with SufBC activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufD 1805829 sufD 7126198 sufD Escherichia coli IAI1 cysteine desulfurase activator complex subunit SufD YP_002387160.1 1804558 R 585034 CDS YP_002387161.1 218554248 7126195 complement(1805804..1806550) 1 NC_011741.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase ATPase 1806550 sufC 7126195 sufC Escherichia coli IAI1 cysteine desulfurase ATPase YP_002387161.1 1805804 R 585034 CDS YP_002387162.1 218554249 7126194 complement(1806560..1808047) 1 NC_011741.1 with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB 1808047 sufB 7126194 sufB Escherichia coli IAI1 cysteine desulfurase activator complex subunit SufB YP_002387162.1 1806560 R 585034 CDS YP_002387163.1 218554250 7126193 complement(1808056..1808424) 1 NC_011741.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein 1808424 sufA 7126193 sufA Escherichia coli IAI1 iron-sulfur cluster assembly scaffold protein YP_002387163.1 1808056 R 585034 CDS YP_002387164.1 218554251 7124651 complement(1808973..1809242) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1809242 ydiH 7124651 ydiH Escherichia coli IAI1 hypothetical protein YP_002387164.1 1808973 R 585034 CDS YP_002387165.1 218554252 7127308 complement(1809261..1809671) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme; hypothetical protein 1809671 ydiI 7127308 ydiI Escherichia coli IAI1 hypothetical protein YP_002387165.1 1809261 R 585034 CDS YP_002387166.1 218554253 7127309 complement(1809668..1812724) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11102686; Product type pe : putative enzyme; putative conserved FAD-linked oxidoreductase 1812724 ydiJ 7127309 ydiJ Escherichia coli IAI1 putative conserved FAD-linked oxidoreductase YP_002387166.1 1809668 R 585034 CDS YP_002387167.1 218554254 7127310 1813113..1814225 1 NC_011741.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; hypothetical protein 1814225 ydiK 7127310 ydiK Escherichia coli IAI1 hypothetical protein YP_002387167.1 1813113 D 585034 CDS YP_002387168.1 218554255 7128406 complement(1814415..1814591) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 1814591 7128406 ECIAI1_1741 Escherichia coli IAI1 hypothetical protein YP_002387168.1 1814415 R 585034 CDS YP_002387169.1 218554256 7126793 1814654..1815010 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1815010 ydiL 7126793 ydiL Escherichia coli IAI1 hypothetical protein YP_002387169.1 1814654 D 585034 CDS YP_002387170.1 218554257 7127312 1815110..1816324 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1816324 ydiM 7127312 ydiM Escherichia coli IAI1 putative MFS superfamily transporter YP_002387170.1 1815110 D 585034 CDS YP_002387171.1 218554258 7127313 1816551..1817816 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 1817816 ydiN 7127313 ydiN Escherichia coli IAI1 putative transporter YP_002387171.1 1816551 D 585034 CDS YP_002387172.1 218554259 7127314 1817828..1818694 1 NC_011741.1 YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase 1818694 ydiB 7127314 ydiB Escherichia coli IAI1 quinate/shikimate dehydrogenase YP_002387172.1 1817828 D 585034 CDS YP_002387173.1 218554260 7127304 1818725..1819483 1 NC_011741.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1819483 aroD 7127304 aroD Escherichia coli IAI1 3-dehydroquinate dehydratase YP_002387173.1 1818725 D 585034 CDS YP_002387174.1 218554261 7125805 1819627..1821222 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16253988; Product type e : enzyme; short chain acyl-CoA transferase subunit alpha/beta 1821222 ydiF 7125805 ydiF Escherichia coli IAI1 short chain acyl-CoA transferase subunit alpha/beta YP_002387174.1 1819627 D 585034 CDS YP_002387175.1 218554262 7127307 1821236..1822387 1 NC_011741.1 may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; putative acyl-CoA dehydrogenase 1822387 ydiO 7127307 ydiO Escherichia coli IAI1 putative acyl-CoA dehydrogenase YP_002387175.1 1821236 D 585034 CDS YP_002387176.1 218554263 7127315 complement(1822430..1823341) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1823341 ydiP 7127315 ydiP Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002387176.1 1822430 R 585034 CDS YP_002387177.1 218554264 7127316 complement(1823444..1823620) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1823620 7127316 ECIAI1_1750 Escherichia coli IAI1 hypothetical protein YP_002387177.1 1823444 R 585034 CDS YP_002387178.1 218554265 7126794 1823657..1824421 1 NC_011741.1 YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; putative electron transfer flavoprotein YdiQ 1824421 ydiQ 7126794 ydiQ Escherichia coli IAI1 putative electron transfer flavoprotein YdiQ YP_002387178.1 1823657 D 585034 CDS YP_002387179.1 218554266 7127317 1824441..1825379 1 NC_011741.1 May play a role in a redox process; electron transfer flavoprotein subunit YdiR 1825379 ydiR 7127317 ydiR Escherichia coli IAI1 electron transfer flavoprotein subunit YdiR YP_002387179.1 1824441 D 585034 CDS YP_002387180.1 218554267 7127318 1825435..1826724 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; hypothetical protein 1826724 ydiS 7127318 ydiS Escherichia coli IAI1 hypothetical protein YP_002387180.1 1825435 D 585034 CDS YP_002387181.1 218554268 7127319 1826721..1827014 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S ferredoxin-type oxidoreductase subunit 1827014 ydiT 7127319 ydiT Escherichia coli IAI1 putative 4Fe-4S ferredoxin-type oxidoreductase subunit YP_002387181.1 1826721 D 585034 CDS YP_002387182.1 218554269 7127320 1827017..1828717 1 NC_011741.1 acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids; short chain acyl-CoA synthetase 1828717 ydiD 7127320 ydiD Escherichia coli IAI1 short chain acyl-CoA synthetase YP_002387182.1 1827017 D 585034 CDS YP_002387183.1 218554270 7127305 complement(1828774..1831152) 1 NC_011741.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase 1831152 pps 7127305 pps Escherichia coli IAI1 phosphoenolpyruvate synthase YP_002387183.1 1828774 R 585034 CDS YP_002387184.1 218554271 7126138 complement(1831206..1831373) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 1831373 7126138 ECIAI1_1757 Escherichia coli IAI1 hypothetical protein YP_002387184.1 1831206 R 585034 CDS YP_002387185.1 218554272 7126795 1831485..1832318 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1832318 ydiA 7126795 ydiA Escherichia coli IAI1 hypothetical protein YP_002387185.1 1831485 D 585034 CDS YP_002387186.1 218554273 7127303 1832475..1833521 1 NC_011741.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 1833521 aroH 7127303 aroH Escherichia coli IAI1 phospho-2-dehydro-3-deoxyheptonate aldolase YP_002387186.1 1832475 D 585034 CDS YP_002387187.1 218554274 7125809 1833653..1833844 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15039350; hypothetical protein 1833844 ydiE 7125809 ydiE Escherichia coli IAI1 hypothetical protein YP_002387187.1 1833653 D 585034 CDS YP_002387188.1 218554275 7127322 complement(1835347..1836060) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1836060 ydiV 7127322 ydiV Escherichia coli IAI1 hypothetical protein YP_002387188.1 1835347 R 585034 CDS YP_002387189.1 218554276 7127323 complement(1836307..1836771) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12620121; Product type lp : lipoprotein; putative peptidase lipoprotein 1836771 nlpC 7127323 nlpC Escherichia coli IAI1 putative peptidase lipoprotein YP_002387189.1 1836307 R 585034 CDS YP_002387190.1 218554277 7127889 complement(1836849..1837598) 1 NC_011741.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase 1837598 btuD 7127889 btuD Escherichia coli IAI1 vitamin B12-transporter ATPase YP_002387190.1 1836849 R 585034 CDS YP_002387191.1 218554278 7124425 complement(1837598..1838149) 1 NC_011741.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; putative glutathione peroxidase 1838149 btuE 7124425 btuE Escherichia coli IAI1 putative glutathione peroxidase YP_002387191.1 1837598 R 585034 CDS YP_002387192.1 218554279 7124426 complement(1838212..1839192) 1 NC_011741.1 with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease 1839192 btuC 7124426 btuC Escherichia coli IAI1 vtamin B12-transporter permease YP_002387192.1 1838212 R 585034 CDS YP_002387193.1 218554280 7124424 complement(1839293..1839592) 1 NC_011741.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 1839592 ihfA 7124424 ihfA Escherichia coli IAI1 integration host factor subunit alpha YP_002387193.1 1839293 R 585034 CDS YP_002387194.1 218554281 7126047 complement(1839597..1841984) 1 NC_011741.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1841984 pheT 7126047 pheT Escherichia coli IAI1 phenylalanyl-tRNA synthetase subunit beta YP_002387194.1 1839597 R 585034 CDS YP_002387195.1 218554282 7124197 complement(1841999..1842982) 1 NC_011741.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1842982 pheS 7124197 pheS Escherichia coli IAI1 phenylalanyl-tRNA synthetase subunit alpha YP_002387195.1 1841999 R 585034 CDS YP_002387197.1 218554284 7124194 complement(1843433..1843789) 1 NC_011741.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1843789 rplT 7124194 rplT Escherichia coli IAI1 50S ribosomal protein L20 YP_002387197.1 1843433 R 585034 CDS YP_002387198.1 218554285 7128381 complement(1843842..1844039) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93085722, 10094780, 3298224, 3542048, 6325158; Product type s : structure; 50S ribosomal protein L35 1844039 rpmI 7128381 rpmI Escherichia coli IAI1 50S ribosomal protein L35 YP_002387198.1 1843842 R 585034 CDS YP_002387199.1 218554286 7126066 complement(1844682..1846610) 1 NC_011741.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 1846610 thrS 7126066 thrS Escherichia coli IAI1 threonyl-tRNA synthetase YP_002387199.1 1844682 R 585034 CDS YP_002387200.1 218554287 7126256 1846895..1846966 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1846966 7126256 ECIAI1_1776 Escherichia coli IAI1 hypothetical protein YP_002387200.1 1846895 D 585034 CDS YP_002387201.1 218554288 7126798 complement(1849338..1850096) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1850096 ydiY 7126798 ydiY Escherichia coli IAI1 hypothetical protein YP_002387201.1 1849338 R 585034 CDS YP_002387202.1 218554289 7127324 1850383..1851312 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 78194149, 88292964, 6235149, 6310120; Product type e : enzyme; 6-phosphofructokinase 2 1851312 pfkB 7127324 pfkB Escherichia coli IAI1 6-phosphofructokinase 2 YP_002387202.1 1850383 D 585034 CDS YP_002387203.1 218554290 7124179 1851413..1851703 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1851703 ydiZ 7124179 ydiZ Escherichia coli IAI1 hypothetical protein YP_002387203.1 1851413 D 585034 CDS YP_002387204.1 218554291 7127325 1851809..1852669 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase/kinase 1852669 yniA 7127325 yniA Escherichia coli IAI1 putative phosphotransferase/kinase YP_002387204.1 1851809 D 585034 CDS YP_002387205.1 218554292 7127575 complement(1852710..1853246) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1853246 yniB 7127575 yniB Escherichia coli IAI1 hypothetical protein YP_002387205.1 1852710 R 585034 CDS YP_002387206.1 218554293 7127576 1853393..1854061 1 NC_011741.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase 1854061 yniC 7127576 yniC Escherichia coli IAI1 2-deoxyglucose-6-phosphatase YP_002387206.1 1853393 D 585034 CDS YP_002387207.1 218554294 7127577 1854224..1854814 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10760155; Product type pm : putative membrane component; hypothetical protein 1854814 ydjM 7127577 ydjM Escherichia coli IAI1 hypothetical protein YP_002387207.1 1854224 D 585034 CDS YP_002387208.1 218554295 7127335 complement(1854746..1854874) 1 NC_011741.1 hypothetical protein 1854874 7127335 ECIAI1_1787 Escherichia coli IAI1 hypothetical protein YP_002387208.1 1854746 R 585034 CDS YP_002387209.1 218554296 7126799 1854947..1856338 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative cation-acid symporter 1856338 ydjN 7126799 ydjN Escherichia coli IAI1 putative cation-acid symporter YP_002387209.1 1854947 D 585034 CDS YP_002387210.1 218554297 7127338 complement(1857434..1857697) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9427399; Product type cp : cell process; cell division modulator 1857697 cedA 7127338 cedA Escherichia coli IAI1 cell division modulator YP_002387210.1 1857434 R 585034 CDS YP_002387211.1 218554298 7126298 1857880..1860141 1 NC_011741.1 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II 1860141 katE 7126298 katE Escherichia coli IAI1 hydroperoxidase II YP_002387211.1 1857880 D 585034 CDS YP_002387212.1 218554299 7126092 complement(1860188..1860946) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 20042356, 1987146, 2179047, 8121401, 9405618; hypothetical protein 1860946 chbG 7126092 chbG Escherichia coli IAI1 hypothetical protein YP_002387212.1 1860188 R 585034 CDS YP_002387213.1 218554300 7126307 complement(1860959..1862311) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20042356, 90185127, 9405618; Product type e : enzyme; cryptic phospho-beta-glucosidase 1862311 chbF 7126307 chbF Escherichia coli IAI1 cryptic phospho-beta-glucosidase YP_002387213.1 1860959 R 585034 CDS YP_002387214.1 218554301 7126306 complement(1862416..1863258) 1 NC_011741.1 represses the celABCDF-ydjC operon involved in carbon uptake; DNA-binding transcriptional regulator ChbR 1863258 chbR 7126306 chbR Escherichia coli IAI1 DNA-binding transcriptional regulator ChbR YP_002387214.1 1862416 R 585034 CDS YP_002387215.1 218554302 7126308 complement(1863266..1863616) 1 NC_011741.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA 1863616 chbA 7126308 chbA Escherichia coli IAI1 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA YP_002387215.1 1863266 R 585034 CDS YP_002387216.1 218554303 7126303 complement(1863667..1865025) 1 NC_011741.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC 1865025 chbC 7126303 chbC Escherichia coli IAI1 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC YP_002387216.1 1863667 R 585034 CDS YP_002387217.1 218554304 7126305 complement(1865110..1865430) 1 NC_011741.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB 1865430 chbB 7126305 chbB Escherichia coli IAI1 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB YP_002387217.1 1865110 R 585034 CDS YP_002387218.1 218554305 7126304 complement(1865729..1866067) 1 NC_011741.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE 1866067 osmE 7126304 osmE Escherichia coli IAI1 DNA-binding transcriptional activator OsmE YP_002387218.1 1865729 R 585034 CDS YP_002387219.1 218554306 7125997 1866269..1867096 1 NC_011741.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1867096 nadE 7125997 nadE Escherichia coli IAI1 NAD synthetase YP_002387219.1 1866269 D 585034 CDS YP_002387220.1 218554307 7124515 1867326..1868213 1 NC_011741.1 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease 1868213 ydjQ 7124515 ydjQ Escherichia coli IAI1 nucleotide excision repair endonuclease YP_002387220.1 1867326 D 585034 CDS YP_002387221.1 218554308 7127339 complement(1868173..1868748) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21862596; hypothetical protein 1868748 ydjR 7127339 ydjR Escherichia coli IAI1 hypothetical protein YP_002387221.1 1868173 R 585034 CDS YP_002387222.1 218554309 7127340 complement(1868951..1869436) 1 NC_011741.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; periplasmic protein 1869436 spy 7127340 spy Escherichia coli IAI1 periplasmic protein YP_002387222.1 1868951 R 585034 CDS YP_002387223.1 218554310 7127966 complement(1869766..1870734) 1 NC_011741.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase 1870734 astE 7127966 astE Escherichia coli IAI1 succinylglutamate desuccinylase YP_002387223.1 1869766 R 585034 CDS YP_002387224.1 218554311 7126273 complement(1870727..1872070) 1 NC_011741.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation; succinylarginine dihydrolase 1872070 astB 7126273 astB Escherichia coli IAI1 succinylarginine dihydrolase YP_002387224.1 1870727 R 585034 CDS YP_002387225.1 218554312 7126270 complement(1872067..1873545) 1 NC_011741.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase 1873545 astD 7126270 astD Escherichia coli IAI1 succinylglutamic semialdehyde dehydrogenase YP_002387225.1 1872067 R 585034 CDS YP_002387226.1 218554313 7126272 complement(1873542..1874576) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14675764, 98361920; Product type e : enzyme; arginine succinyltransferase 1874576 astA 7126272 astA Escherichia coli IAI1 arginine succinyltransferase YP_002387226.1 1873542 R 585034 CDS YP_002387227.1 218554314 7126269 complement(1874573..1875793) 1 NC_011741.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate; bifunctional succinylornithine transaminase/acetylornithine transaminase 1875793 astC 7126269 astC Escherichia coli IAI1 bifunctional succinylornithine transaminase/acetylornithine transaminase YP_002387227.1 1874573 R 585034 CDS YP_002387228.1 218554315 7126271 1876239..1877045 1 NC_011741.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 1877045 xthA 7126271 xthA Escherichia coli IAI1 exonuclease III YP_002387228.1 1876239 D 585034 CDS YP_002387229.1 218554316 7126476 1877212..1877922 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1877922 ydjX 7126476 ydjX Escherichia coli IAI1 hypothetical protein YP_002387229.1 1877212 D 585034 CDS YP_002387230.1 218554317 7127341 1877927..1878604 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1878604 ydjY 7127341 ydjY Escherichia coli IAI1 hypothetical protein YP_002387230.1 1877927 D 585034 CDS YP_002387231.1 218554318 7127342 1878619..1879326 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1879326 ydjZ 7127342 ydjZ Escherichia coli IAI1 hypothetical protein YP_002387231.1 1878619 D 585034 CDS YP_002387232.1 218554319 7127343 1879326..1879874 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1879874 ynjA 7127343 ynjA Escherichia coli IAI1 hypothetical protein YP_002387232.1 1879326 D 585034 CDS YP_002387233.1 218554320 7127578 1879884..1881050 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative ABC transporter solute-binding protein 1881050 ynjB 7127578 ynjB Escherichia coli IAI1 putative ABC transporter solute-binding protein YP_002387233.1 1879884 D 585034 CDS YP_002387234.1 218554321 7127579 1881068..1882558 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter membrane protein 1882558 ynjC 7127579 ynjC Escherichia coli IAI1 putative ABC transporter membrane protein YP_002387234.1 1881068 D 585034 CDS YP_002387235.1 218554322 7127580 1882558..1883211 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sulfate/thiosulfate ABC transporter ATP-binding protein 1883211 ynjD 7127580 ynjD Escherichia coli IAI1 putative sulfate/thiosulfate ABC transporter ATP-binding protein YP_002387235.1 1882558 D 585034 CDS YP_002387236.1 218554323 7127581 1883278..1884585 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported thiosulfate sulfur transferase / thiosulfate binding protein 1884585 ynjE 7127581 ynjE Escherichia coli IAI1 putative exported thiosulfate sulfur transferase / thiosulfate binding protein YP_002387236.1 1883278 D 585034 CDS YP_002387237.1 218554324 7127582 complement(1884594..1885214) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type m : membrane component; putative phosphatidyl transferase, inner membrane protein 1885214 ynjF 7127582 ynjF Escherichia coli IAI1 putative phosphatidyl transferase, inner membrane protein YP_002387237.1 1884594 R 585034 CDS YP_002387238.1 218554325 7127583 1885301..1885708 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101911; Product type e : enzyme; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 1885708 nudG 7127583 nudG Escherichia coli IAI1 pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase YP_002387238.1 1885301 D 585034 CDS YP_002387239.1 218554326 7125956 complement(1885674..1885946) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1885946 ynjH 7125956 ynjH Escherichia coli IAI1 hypothetical protein YP_002387239.1 1885674 R 585034 CDS YP_002387240.1 218554327 7127584 1886182..1887525 1 NC_011741.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1887525 gdhA 7127584 gdhA Escherichia coli IAI1 glutamate dehydrogenase YP_002387240.1 1886182 D 585034 CDS YP_002387241.1 218554328 7128300 complement(1887642..1888682) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1888682 ynjI 7128300 ynjI Escherichia coli IAI1 hypothetical protein YP_002387241.1 1887642 R 585034 CDS YP_002387242.1 218554329 7127585 complement(1888810..1890771) 1 NC_011741.1 decatenates replicating daughter chromosomes; DNA topoisomerase III 1890771 topB 7127585 topB Escherichia coli IAI1 DNA topoisomerase III YP_002387242.1 1888810 R 585034 CDS YP_002387243.1 218554330 7127465 complement(1890776..1891819) 1 NC_011741.1 catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 1891819 selD 7127465 selD Escherichia coli IAI1 selenophosphate synthetase YP_002387243.1 1890776 R 585034 CDS YP_002387244.1 218554331 7126968 complement(1891761..1891910) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1891910 7126968 ECIAI1_1826 Escherichia coli IAI1 hypothetical protein YP_002387244.1 1891761 R 585034 CDS YP_002387245.1 218554332 7126800 complement(1891936..1892487) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 1892487 ydjA 7126800 ydjA Escherichia coli IAI1 hypothetical protein YP_002387245.1 1891936 R 585034 CDS YP_002387246.1 218554333 7127326 1892541..1892705 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1892705 7127326 ECIAI1_1828 Escherichia coli IAI1 hypothetical protein YP_002387246.1 1892541 D 585034 CDS YP_002387247.1 218554334 7126801 1892648..1894504 1 NC_011741.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 1894504 sppA 7126801 sppA Escherichia coli IAI1 protease 4 YP_002387247.1 1892648 D 585034 CDS YP_002387248.1 218554335 7127963 1894671..1895687 1 NC_011741.1 converts asparagine to aspartate and ammonia; cytoplasmic asparaginase I 1895687 ansA 7127963 ansA Escherichia coli IAI1 cytoplasmic asparaginase I YP_002387248.1 1894671 D 585034 CDS YP_002387249.1 218554336 7125764 1895698..1896339 1 NC_011741.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase 1896339 pncA 7125764 pncA Escherichia coli IAI1 nicotinamidase/pyrazinamidase YP_002387249.1 1895698 D 585034 CDS YP_002387250.1 218554337 7126105 complement(1896432..1897790) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1897790 ydjE 7126105 ydjE Escherichia coli IAI1 putative MFS superfamily transporter YP_002387250.1 1896432 R 585034 CDS YP_002387251.1 218554338 7127327 complement(1897907..1898665) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1898665 ydjF 7127327 ydjF Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002387251.1 1897907 R 585034 CDS YP_002387252.1 218554339 7127328 complement(1898802..1899782) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1899782 ydjG 7127328 ydjG Escherichia coli IAI1 putative oxidoreductase YP_002387252.1 1898802 R 585034 CDS YP_002387253.1 218554340 7127329 complement(1899792..1900739) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar kinase 1900739 ydjH 7127329 ydjH Escherichia coli IAI1 putative sugar kinase YP_002387253.1 1899792 R 585034 CDS YP_002387254.1 218554341 7127330 complement(1900744..1901580) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldolase 1901580 ydjI 7127330 ydjI Escherichia coli IAI1 putative aldolase YP_002387254.1 1900744 R 585034 CDS YP_002387255.1 218554342 7127331 complement(1901601..1902644) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12897001; Product type pe : putative enzyme; putative iditol dehydrogenase 1902644 ydjJ 7127331 ydjJ Escherichia coli IAI1 putative iditol dehydrogenase YP_002387255.1 1901601 R 585034 CDS YP_002387256.1 218554343 7127332 complement(1902661..1904040) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1904040 ydjK 7127332 ydjK Escherichia coli IAI1 putative MFS superfamily transporter YP_002387256.1 1902661 R 585034 CDS YP_002387257.1 218554344 7127333 complement(1904067..1905143) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1905143 ydjL 7127333 ydjL Escherichia coli IAI1 putative oxidoreductase YP_002387257.1 1904067 R 585034 CDS YP_002387258.1 218554345 7127334 complement(1905513..1905785) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1905785 yeaC 7127334 yeaC Escherichia coli IAI1 hypothetical protein YP_002387258.1 1905513 R 585034 CDS YP_002387259.1 218554346 7127345 complement(1905827..1906240) 1 NC_011741.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 1906240 msrB 7127345 msrB Escherichia coli IAI1 methionine sulfoxide reductase B YP_002387259.1 1905827 R 585034 CDS YP_002387260.1 218554347 7124482 1906582..1907577 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 775311, 94131963, 98361923, 1862091, 2124629, 2990926, 7896119, 8636984, 9298646; Product type e : enzyme; glyceraldehyde-3-phosphate dehydrogenase A 1907577 gapA 7124482 gapA Escherichia coli IAI1 glyceraldehyde-3-phosphate dehydrogenase A YP_002387260.1 1906582 D 585034 CDS YP_002387261.1 218554348 7128277 1907661..1908545 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1908545 yeaD 7128277 yeaD Escherichia coli IAI1 hypothetical protein YP_002387261.1 1907661 D 585034 CDS YP_002387262.1 218554349 7127346 complement(1908596..1909450) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1909450 yeaE 7127346 yeaE Escherichia coli IAI1 putative oxidoreductase YP_002387262.1 1908596 R 585034 CDS YP_002387263.1 218554350 7127347 complement(1909540..1910286) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10037771, 20267815; Product type f : factor; scaffolding protein for murein synthesizing machinery 1910286 mipA 7127347 mipA Escherichia coli IAI1 scaffolding protein for murein synthesizing machinery YP_002387263.1 1909540 R 585034 CDS YP_002387264.1 218554351 7124279 1910722..1912656 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1912656 yeaG 7124279 yeaG Escherichia coli IAI1 hypothetical protein YP_002387264.1 1910722 D 585034 CDS YP_002387265.1 218554352 7127348 1912769..1914052 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1914052 yeaH 7127348 yeaH Escherichia coli IAI1 hypothetical protein YP_002387265.1 1912769 D 585034 CDS YP_002387266.1 218554353 7127349 1914199..1915674 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase 1915674 yeaI 7127349 yeaI Escherichia coli IAI1 putative diguanylate cyclase YP_002387266.1 1914199 D 585034 CDS YP_002387267.1 218554354 7127350 1915855..1917345 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase 1917345 yeaJ 7127350 yeaJ Escherichia coli IAI1 putative diguanylate cyclase YP_002387267.1 1915855 D 585034 CDS YP_002387268.1 218554355 7127351 1917388..1917891 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1917891 yeaK 7127351 yeaK Escherichia coli IAI1 hypothetical protein YP_002387268.1 1917388 D 585034 CDS YP_002387269.1 218554356 7127352 complement(1917892..1918044) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 1918044 7127352 ECIAI1_1852 Escherichia coli IAI1 hypothetical protein YP_002387269.1 1917892 R 585034 CDS YP_002387270.1 218554357 7126802 1918166..1918612 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1918612 yeaL 7126802 yeaL Escherichia coli IAI1 hypothetical protein YP_002387270.1 1918166 D 585034 CDS YP_002387271.1 218554358 7127353 complement(1918569..1919390) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1919390 yeaM 7127353 yeaM Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002387271.1 1918569 R 585034 CDS YP_002387272.1 218554359 7127354 1919487..1920668 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1920668 yeaN 7127354 yeaN Escherichia coli IAI1 putative MFS superfamily transporter YP_002387272.1 1919487 D 585034 CDS YP_002387273.1 218554360 7127355 1920723..1921070 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1921070 yeaO 7127355 yeaO Escherichia coli IAI1 hypothetical protein YP_002387273.1 1920723 D 585034 CDS YP_002387274.1 218554361 7127356 complement(1921092..1921346) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1921346 yoaF 7127356 yoaF Escherichia coli IAI1 hypothetical protein YP_002387274.1 1921092 R 585034 CDS YP_002387275.1 218554362 7127590 1921529..1922554 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase 1922554 yeaP 7127590 yeaP Escherichia coli IAI1 putative diguanylate cyclase YP_002387275.1 1921529 D 585034 CDS YP_002387276.1 218554363 7127357 complement(1922821..1923069) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1923069 yeaQ 7127357 yeaQ Escherichia coli IAI1 hypothetical protein YP_002387276.1 1922821 R 585034 CDS YP_002387277.1 218554364 7127358 complement(1923081..1923266) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1923266 7127358 ECIAI1_1861 Escherichia coli IAI1 hypothetical protein YP_002387277.1 1923081 R 585034 CDS YP_002387278.1 218554365 7126803 complement(1923296..1924504) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase 1924504 ydcM 7126803 ydcM Escherichia coli IAI1 putative transposase YP_002387278.1 1923296 R 585034 CDS YP_002387279.1 218554366 7127381 1923722..1923853 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1923853 7127381 ECIAI1_1863 Escherichia coli IAI1 hypothetical protein YP_002387279.1 1923722 D 585034 CDS YP_002387280.1 218554367 7126804 complement(1924482..1924628) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 1924628 7126804 ECIAI1_1864 Escherichia coli IAI1 hypothetical protein YP_002387280.1 1924482 R 585034 CDS YP_002387281.1 218554368 7126805 complement(1924959..1925147) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1925147 7126805 ECIAI1_1865 Escherichia coli IAI1 hypothetical protein YP_002387281.1 1924959 R 585034 CDS YP_002387282.1 218554369 7126806 complement(1925151..1925510) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1925510 yeaR 7126806 yeaR Escherichia coli IAI1 hypothetical protein YP_002387282.1 1925151 R 585034 CDS YP_002387283.1 218554370 7127359 complement(1925683..1926321) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; leucine export protein LeuE 1926321 yeaS 7127359 yeaS Escherichia coli IAI1 leucine export protein LeuE YP_002387283.1 1925683 R 585034 CDS YP_002387284.1 218554371 7127360 complement(1926448..1927371) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1927371 yeaT 7127360 yeaT Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002387284.1 1926448 R 585034 CDS YP_002387285.1 218554372 7127361 1927474..1928559 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative tartrate dehydrogenase 1928559 yeaU 7127361 yeaU Escherichia coli IAI1 putative tartrate dehydrogenase YP_002387285.1 1927474 D 585034 CDS YP_002387286.1 218554373 7127362 1928975..1930420 1 NC_011741.1 member of the betaine, carnitine, choline transporter (BCCT) family; unknown function; putative transporter 1930420 yeaV 7127362 yeaV Escherichia coli IAI1 putative transporter YP_002387286.1 1928975 D 585034 CDS YP_002387287.1 218554374 7127363 1930452..1931576 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 2Fe-2S cluster-containing dioxygenase subunit 1931576 yeaW 7127363 yeaW Escherichia coli IAI1 putative 2Fe-2S cluster-containing dioxygenase subunit YP_002387287.1 1930452 D 585034 CDS YP_002387288.1 218554375 7127364 1931632..1932597 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dioxygenase subunit 1932597 yeaX 7127364 yeaX Escherichia coli IAI1 putative dioxygenase subunit YP_002387288.1 1931632 D 585034 CDS YP_002387289.1 218554376 7127365 complement(1932651..1933778) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88289400, 89053950, 93015723, 8107670; Product type e : enzyme; ribonuclease D 1933778 rnd 7127365 rnd Escherichia coli IAI1 ribonuclease D YP_002387289.1 1932651 R 585034 CDS YP_002387290.1 218554377 7125019 complement(1933848..1935533) 1 NC_011741.1 Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1935533 fadD 7125019 fadD Escherichia coli IAI1 long-chain-fatty-acid--CoA ligase YP_002387290.1 1933848 R 585034 CDS YP_002387291.1 218554378 7127063 complement(1935738..1936319) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16079137; Product type lp : lipoprotein; putative outer membrane-associated lipoprotein 1936319 yeaY 7127063 yeaY Escherichia coli IAI1 putative outer membrane-associated lipoprotein YP_002387291.1 1935738 R 585034 CDS YP_002387292.1 218554379 7127366 complement(1936359..1937054) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 1937054 yeaZ 7127366 yeaZ Escherichia coli IAI1 putative peptidase YP_002387292.1 1936359 R 585034 CDS YP_002387293.1 218554380 7127367 complement(1937112..1939022) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-dependent helicase 1939022 yoaA 7127367 yoaA Escherichia coli IAI1 putative ATP-dependent helicase YP_002387293.1 1937112 R 585034 CDS YP_002387294.1 218554381 7127586 1939154..1939498 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1939498 yoaB 7127586 yoaB Escherichia coli IAI1 hypothetical protein YP_002387294.1 1939154 D 585034 CDS YP_002387295.1 218554382 7127587 1939861..1940220 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1940220 yoaC 7127587 yoaC Escherichia coli IAI1 hypothetical protein YP_002387295.1 1939861 D 585034 CDS YP_002387296.1 218554383 7127588 complement(1940340..1940519) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1940519 yoaH 7127588 yoaH Escherichia coli IAI1 hypothetical protein YP_002387296.1 1940340 R 585034 CDS YP_002387297.1 218554384 7127591 1940593..1941954 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88025006, 91067712, 91302313, 96011382, 6330050, 7896119; Product type e : enzyme; aminodeoxychorismate synthase subunit I 1941954 pabB 7127591 pabB Escherichia coli IAI1 aminodeoxychorismate synthase subunit I YP_002387297.1 1940593 D 585034 CDS YP_002387298.1 218554385 7124147 1941958..1942536 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pe : putative enzyme; hypothetical protein 1942536 yeaB 7124147 yeaB Escherichia coli IAI1 hypothetical protein YP_002387298.1 1941958 D 585034 CDS YP_002387299.1 218554386 7127344 1942720..1944084 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15155761, 89359152, 91056090, 93170282; Product type e : enzyme; L-serine deaminase I 1944084 sdaA 7127344 sdaA Escherichia coli IAI1 L-serine deaminase I YP_002387299.1 1942720 D 585034 CDS YP_002387300.1 218554387 7124683 1944215..1945813 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16513732; Product type pe : putative enzyme; putative cyclic di-GMP phosphodiesterase 1945813 adrB 7124683 adrB Escherichia coli IAI1 putative cyclic di-GMP phosphodiesterase YP_002387300.1 1944215 D 585034 CDS YP_002387301.1 218554388 7125723 complement(1945817..1947373) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 1947373 yoaE 7125723 yoaE Escherichia coli IAI1 hypothetical protein YP_002387301.1 1945817 R 585034 CDS YP_002387302.1 218554389 7127589 1947836..1948807 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87165962, 90036983, 8131846, 8676384, 9074635, 9298646; Product type t : transporter; PTS system mannose-specific transporter subunit IIAB 1948807 manX 7127589 manX Escherichia coli IAI1 PTS system mannose-specific transporter subunit IIAB YP_002387302.1 1947836 D 585034 CDS YP_002387303.1 218554390 7127668 1948870..1949670 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10473571, 87165962, 90036983, 94086520, 97128775, 7811395, 8774730; Product type t : transporter; mannose-specific PTS system transporter subunit IIC 1949670 manY 7127668 manY Escherichia coli IAI1 mannose-specific PTS system transporter subunit IIC YP_002387303.1 1948870 D 585034 CDS YP_002387304.1 218554391 7127669 1949674..1950534 1 NC_011741.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 1950534 manZ 7127669 manZ Escherichia coli IAI1 PTS system mannose-specific transporter subunit IID YP_002387304.1 1949674 D 585034 CDS YP_002387305.1 218554392 7127670 1950589..1951047 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1951047 yobD 7127670 yobD Escherichia coli IAI1 hypothetical protein YP_002387305.1 1950589 D 585034 CDS YP_002387306.1 218554393 7127594 1951234..1951479 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 1951479 7127594 ECIAI1_1890 Escherichia coli IAI1 hypothetical protein YP_002387306.1 1951234 D 585034 CDS YP_002387307.1 218554394 7126807 1951476..1952042 1 NC_011741.1 membrane protein YebN; hypothetical protein 1952042 yebN 7126807 yebN Escherichia coli IAI1 hypothetical protein YP_002387307.1 1951476 D 585034 CDS YP_002387308.1 218554395 7125194 complement(1952039..1952848) 1 NC_011741.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase A 1952848 rrmA 7125194 rrmA Escherichia coli IAI1 23S rRNA methyltransferase A YP_002387308.1 1952039 R 585034 CDS YP_002387309.1 218554396 7128429 complement(1953014..1953223) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20345064, 21101802, 94293754, 12071744, 7984109, 8022261, 9298646, 9868784, 9921691; Product type f : factor; cold shock-like protein CspC 1953223 cspC 7128429 cspC Escherichia coli IAI1 cold shock-like protein CspC YP_002387309.1 1953014 R 585034 CDS YP_002387310.1 218554397 7125933 complement(1953236..1953379) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1953379 yobF 7125933 yobF Escherichia coli IAI1 hypothetical protein YP_002387310.1 1953236 R 585034 CDS YP_002387311.1 218554398 7127595 complement(1954048..1954335) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1954335 yebO 7127595 yebO Escherichia coli IAI1 hypothetical protein YP_002387311.1 1954048 R 585034 CDS YP_002387312.1 218554399 7125195 complement(1954410..1954553) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1954553 yobG 7125195 yobG Escherichia coli IAI1 hypothetical protein YP_002387312.1 1954410 R 585034 CDS YP_002387313.1 218554400 7127596 1954712..1954951 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1954951 yobH 7127596 yobH Escherichia coli IAI1 hypothetical protein YP_002387313.1 1954712 D 585034 CDS YP_002387314.1 218554401 7127597 complement(1955094..1955885) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659677, 4359651; Product type r : regulator; DNA-binding transcriptional repressor KdgR 1955885 kdgR 7127597 kdgR Escherichia coli IAI1 DNA-binding transcriptional repressor KdgR YP_002387314.1 1955094 R 585034 CDS YP_002387315.1 218554402 7126371 1956062..1957435 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1957435 yebQ 7126371 yebQ Escherichia coli IAI1 putative MFS superfamily transporter YP_002387315.1 1956062 D 585034 CDS YP_002387316.1 218554403 7125196 complement(1957481..1958362) 1 NC_011741.1 putative metalloprotease; heat shock protein HtpX 1958362 htpX 7125196 htpX Escherichia coli IAI1 heat shock protein HtpX YP_002387316.1 1957481 R 585034 CDS YP_002387317.1 218554404 7125319 complement(1958554..1960602) 1 NC_011741.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 1960602 prc 7125319 prc Escherichia coli IAI1 carboxy-terminal protease YP_002387317.1 1958554 R 585034 CDS YP_002387318.1 218554405 7126143 complement(1960622..1961275) 1 NC_011741.1 affects solute and DNA transport through an unknown mechanism; putative solute/DNA competence effector 1961275 proQ 7126143 proQ Escherichia coli IAI1 putative solute/DNA competence effector YP_002387318.1 1960622 R 585034 CDS YP_002387319.1 218554406 7126160 complement(1961372..1961923) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1961923 yebR 7126160 yebR Escherichia coli IAI1 hypothetical protein YP_002387319.1 1961372 R 585034 CDS YP_002387320.1 218554407 7125197 1961999..1963282 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1963282 yebS 7125197 yebS Escherichia coli IAI1 hypothetical protein YP_002387320.1 1961999 D 585034 CDS YP_002387321.1 218554408 7125198 1963251..1965884 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1965884 yebT 7125198 yebT Escherichia coli IAI1 hypothetical protein YP_002387321.1 1963251 D 585034 CDS YP_002387322.1 218554409 7125199 1965964..1967403 1 NC_011741.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF 1967403 yebU 7125199 yebU Escherichia coli IAI1 rRNA (cytosine-C(5)-)-methyltransferase RsmF YP_002387322.1 1965964 D 585034 CDS YP_002387323.1 218554410 7125200 1967521..1967757 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1967757 yebV 7125200 yebV Escherichia coli IAI1 hypothetical protein YP_002387323.1 1967521 D 585034 CDS YP_002387324.1 218554411 7125201 1967778..1968053 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1968053 yebW 7125201 yebW Escherichia coli IAI1 hypothetical protein YP_002387324.1 1967778 D 585034 CDS YP_002387325.1 218554412 7125202 complement(1968054..1968710) 1 NC_011741.1 Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins; serine/threonine protein phosphatase 1 1968710 pphA 7125202 pphA Escherichia coli IAI1 serine/threonine protein phosphatase 1 YP_002387325.1 1968054 R 585034 CDS YP_002387326.1 218554413 7126808 complement(1969106..1969447) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1969447 yebY 7126808 yebY Escherichia coli IAI1 hypothetical protein YP_002387326.1 1969106 R 585034 CDS YP_002387327.1 218554414 7125203 complement(1969460..1970332) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1970332 yebZ 7125203 yebZ Escherichia coli IAI1 hypothetical protein YP_002387327.1 1969460 R 585034 CDS YP_002387328.1 218554415 7125204 complement(1970336..1970710) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1970710 yobA 7125204 yobA Escherichia coli IAI1 hypothetical protein YP_002387328.1 1970336 R 585034 CDS YP_002387329.1 218554416 7127592 1970849..1971079 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15090519, 92147649, 92156151, 94131961, 1575709, 8341603, 8505306; Product type e : enzyme; DNA polymerase III subunit theta 1971079 holE 7127592 holE Escherichia coli IAI1 DNA polymerase III subunit theta YP_002387329.1 1970849 D 585034 CDS YP_002387330.1 218554417 7125295 1971181..1971837 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1971837 yobB 7125295 yobB Escherichia coli IAI1 hypothetical protein YP_002387330.1 1971181 D 585034 CDS YP_002387331.1 218554418 7127593 1971861..1972523 1 NC_011741.1 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 1972523 exoX 7127593 exoX Escherichia coli IAI1 exodeoxyribonuclease X YP_002387331.1 1971861 D 585034 CDS YP_002387332.1 218554419 7127049 complement(1972520..1974580) 1 NC_011741.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 1974580 ptrB 7127049 ptrB Escherichia coli IAI1 protease 2 YP_002387332.1 1972520 R 585034 CDS YP_002387333.1 218554420 7126537 complement(1974789..1975448) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1975448 yebE 7126537 yebE Escherichia coli IAI1 hypothetical protein YP_002387333.1 1974789 R 585034 CDS YP_002387334.1 218554421 7125190 complement(1975775..1976143) 1 NC_011741.1 secreted protein; unknown function; hypothetical protein 1976143 yebF 7125190 yebF Escherichia coli IAI1 hypothetical protein YP_002387334.1 1975775 R 585034 CDS YP_002387335.1 218554422 7125191 complement(1976198..1976488) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9368369, 99403401; Product type cp : cell process; DNA damage-inducible protein YebG 1976488 yebG 7125191 yebG Escherichia coli IAI1 DNA damage-inducible protein YebG YP_002387335.1 1976198 R 585034 CDS YP_002387336.1 218554423 7125192 1976622..1977800 1 NC_011741.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 1977800 purT 7125192 purT Escherichia coli IAI1 phosphoribosylglycinamide formyltransferase 2 YP_002387336.1 1976622 D 585034 CDS YP_002387337.1 218554424 7126556 complement(1977856..1978497) 1 NC_011741.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 1978497 eda 7126556 eda Escherichia coli IAI1 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_002387337.1 1977856 R 585034 CDS YP_002387338.1 218554425 7125048 complement(1978534..1980345) 1 NC_011741.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 1980345 edd 7125048 edd Escherichia coli IAI1 phosphogluconate dehydratase YP_002387338.1 1978534 R 585034 CDS YP_002387339.1 218554426 7125049 complement(1980580..1982055) 1 NC_011741.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1982055 zwf 7125049 zwf Escherichia coli IAI1 glucose-6-phosphate 1-dehydrogenase YP_002387339.1 1980580 R 585034 CDS YP_002387340.1 218554427 7128136 1982393..1983262 1 NC_011741.1 Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR 1983262 yebK 7128136 yebK Escherichia coli IAI1 DNA-binding transcriptional regulator HexR YP_002387340.1 1982393 D 585034 CDS YP_002387341.1 218554428 7125193 1983390..1984832 1 NC_011741.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1984832 pykA 7125193 pykA Escherichia coli IAI1 pyruvate kinase YP_002387341.1 1983390 D 585034 CDS YP_002387342.1 218554429 7126567 complement(1984892..1985701) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1985701 7126567 ECIAI1_1928 Escherichia coli IAI1 hypothetical protein YP_002387342.1 1984892 R 585034 CDS YP_002387343.1 218554430 7126809 complement(1985756..1986595) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1986595 7126809 ECIAI1_1929 Escherichia coli IAI1 hypothetical protein YP_002387343.1 1985756 R 585034 CDS YP_002387344.1 218554431 7126810 complement(1986688..1987494) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Metal-dependent hydrolase 1987494 7126810 ECIAI1_1930 Escherichia coli IAI1 putative Metal-dependent hydrolase YP_002387344.1 1986688 R 585034 CDS YP_002387345.1 218554432 7126811 complement(1987507..1989306) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2482332, 12547200; Product type e : enzyme; Neopullulanase 1989306 7126811 ECIAI1_1931 Escherichia coli IAI1 Neopullulanase YP_002387345.1 1987507 R 585034 CDS YP_002387346.1 218554433 7126812 complement(1989324..1990163) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8594196; Product type t : transporter; maltosaccharide ABC transporter permease 1990163 7126812 ECIAI1_1932 Escherichia coli IAI1 maltosaccharide ABC transporter permease YP_002387346.1 1989324 R 585034 CDS YP_002387347.1 218554434 7126813 complement(1990160..1991449) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8594196; Product type pt : putative transporter; putative sugar ABC transporter permease/inner membrane protein CymF 1991449 7126813 ECIAI1_1933 Escherichia coli IAI1 putative sugar ABC transporter permease/inner membrane protein CymF YP_002387347.1 1990160 R 585034 CDS YP_002387348.1 218554435 7126814 complement(1991452..1992774) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8594196; Product type pt : putative transporter; putative sugar ABC transporter maltose-binding protein CymE 1992774 7126814 ECIAI1_1934 Escherichia coli IAI1 putative sugar ABC transporter maltose-binding protein CymE YP_002387348.1 1991452 R 585034 CDS YP_002387349.1 218554436 7126815 1992957..1993994 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8594196; Product type pt : putative transporter; putative exported protein porin 1993994 7126815 ECIAI1_1935 Escherichia coli IAI1 putative exported protein porin YP_002387349.1 1992957 D 585034 CDS YP_002387350.1 218554437 7126816 1994013..1994969 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8594196; Product type pe : putative enzyme; putative UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 1994969 7126816 ECIAI1_1936 Escherichia coli IAI1 putative UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_002387350.1 1994013 D 585034 CDS YP_002387351.1 218554438 7126817 1995060..1995548 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative CymC protein 1995548 7126817 ECIAI1_1937 Escherichia coli IAI1 putative CymC protein YP_002387351.1 1995060 D 585034 CDS YP_002387352.1 218554439 7126818 1995631..1996758 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8594196; Product type t : transporter; sugar ABC transporter ATP-binding protein CymD 1996758 7126818 ECIAI1_1938 Escherichia coli IAI1 sugar ABC transporter ATP-binding protein CymD YP_002387352.1 1995631 D 585034 CDS YP_002387353.1 218554440 7126819 1997120..1997974 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8594196; hypothetical protein 1997974 7126819 ECIAI1_1939 Escherichia coli IAI1 hypothetical protein YP_002387353.1 1997120 D 585034 CDS YP_002387354.1 218554441 7126820 1998063..1999931 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1999931 7126820 ECIAI1_1940 Escherichia coli IAI1 hypothetical protein YP_002387354.1 1998063 D 585034 CDS YP_002387355.1 218554442 7126821 1999968..2003042 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative alpha-mannosidase 2003042 7126821 ECIAI1_1941 Escherichia coli IAI1 putative alpha-mannosidase YP_002387355.1 1999968 D 585034 CDS YP_002387356.1 218554443 7126822 complement(2003131..2004102) 1 NC_011741.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 2004102 lpxM 7126822 lpxM Escherichia coli IAI1 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_002387356.1 2003131 R 585034 CDS YP_002387357.1 218554444 7127629 complement(2004222..2005544) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1732206; Product type pe : putative enzyme; hypothetical protein 2005544 yebA 7127629 yebA Escherichia coli IAI1 hypothetical protein YP_002387357.1 2004222 R 585034 CDS YP_002387358.1 218554445 7127368 complement(2005560..2006492) 1 NC_011741.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic component 2006492 znuA 7127368 znuA Escherichia coli IAI1 high-affinity zinc transporter periplasmic component YP_002387358.1 2005560 R 585034 CDS YP_002387359.1 218554446 7128128 2006571..2007326 1 NC_011741.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase 2007326 znuC 7128128 znuC Escherichia coli IAI1 high-affinity zinc transporter ATPase YP_002387359.1 2006571 D 585034 CDS YP_002387360.1 218554447 7128130 2007323..2008108 1 NC_011741.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane component 2008108 znuB 7128130 znuB Escherichia coli IAI1 high-affinity zinc transporter membrane component YP_002387360.1 2007323 D 585034 CDS YP_002387361.1 218554448 7128129 complement(2008255..2009265) 1 NC_011741.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 2009265 ruvB 7128129 ruvB Escherichia coli IAI1 Holliday junction DNA helicase RuvB YP_002387361.1 2008255 R 585034 CDS YP_002387362.1 218554449 7124645 complement(2009274..2009885) 1 NC_011741.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 2009885 ruvA 7124645 ruvA Escherichia coli IAI1 Holliday junction DNA helicase RuvA YP_002387362.1 2009274 R 585034 CDS YP_002387363.1 218554450 7124644 2010160..2010762 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2010762 yebB 7124644 yebB Escherichia coli IAI1 hypothetical protein YP_002387363.1 2010160 D 585034 CDS YP_002387364.1 218554451 7124542 complement(2010764..2011285) 1 NC_011741.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 2011285 ruvC 7124542 ruvC Escherichia coli IAI1 Holliday junction resolvase YP_002387364.1 2010764 R 585034 CDS YP_002387365.1 218554452 7124646 complement(2011320..2012060) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2012060 yebC 7124646 yebC Escherichia coli IAI1 hypothetical protein YP_002387365.1 2011320 R 585034 CDS YP_002387366.1 218554453 7125189 complement(2012089..2012541) 1 NC_011741.1 converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 2012541 ntpA 7125189 ntpA Escherichia coli IAI1 dATP pyrophosphohydrolase YP_002387366.1 2012089 R 585034 CDS YP_002387367.1 218554454 7125951 complement(2012659..2014431) 1 NC_011741.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 2014431 aspS 7125951 aspS Escherichia coli IAI1 aspartyl-tRNA synthetase YP_002387367.1 2012659 R 585034 CDS YP_002387368.1 218554455 7126267 2014741..2015307 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2015307 yecD 7126267 yecD Escherichia coli IAI1 hypothetical protein YP_002387368.1 2014741 D 585034 CDS YP_002387369.1 218554456 7125207 2015304..2016122 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2129559, 7984428; hypothetical protein 2016122 yecE 7125207 yecE Escherichia coli IAI1 hypothetical protein YP_002387369.1 2015304 D 585034 CDS YP_002387370.1 218554457 7125208 2016175..2016570 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2016570 yecN 7125208 yecN Escherichia coli IAI1 hypothetical protein YP_002387370.1 2016175 D 585034 CDS YP_002387371.1 218554458 7125215 2016611..2017354 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11746687; Product type e : enzyme; AdoMet-dependent methyltransferase 2017354 yecO 7125215 yecO Escherichia coli IAI1 AdoMet-dependent methyltransferase YP_002387371.1 2016611 D 585034 CDS YP_002387372.1 218554459 7125216 2017351..2018322 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2018322 yecP 7125216 yecP Escherichia coli IAI1 hypothetical protein YP_002387372.1 2017351 D 585034 CDS YP_002387373.1 218554460 7125217 complement(2018487..2020916) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97077292, 11004177; Product type e : enzyme; trimethylamine N-oxide reductase system III, catalytic subunit 2020916 torZ 7125217 torZ Escherichia coli IAI1 trimethylamine N-oxide reductase system III, catalytic subunit YP_002387373.1 2018487 R 585034 CDS YP_002387374.1 218554461 7127473 complement(2020941..2022041) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461225, 8919859; Product type c : carrier; TMAO reductase III (TorYZ), cytochrome c-type subunit 2022041 torY 7127473 torY Escherichia coli IAI1 TMAO reductase III (TorYZ), cytochrome c-type subunit YP_002387374.1 2020941 R 585034 CDS YP_002387375.1 218554462 7127472 complement(2022429..2023175) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95362641, 7635807; Product type t : transporter; copper homeostasis protein CutC 2023175 cutC 7127472 cutC Escherichia coli IAI1 copper homeostasis protein CutC YP_002387375.1 2022429 R 585034 CDS YP_002387376.1 218554463 7126866 complement(2023189..2023755) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12660999; Product type pe : putative enzyme; hypothetical protein 2023755 yecM 7126866 yecM Escherichia coli IAI1 hypothetical protein YP_002387376.1 2023189 R 585034 CDS YP_002387377.1 218554464 7125214 2023971..2025704 1 NC_011741.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 2025704 argS 7125214 argS Escherichia coli IAI1 arginyl-tRNA synthetase YP_002387377.1 2023971 D 585034 CDS YP_002387378.1 218554465 7125798 2025881..2026369 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2026369 yecT 7125798 yecT Escherichia coli IAI1 hypothetical protein YP_002387378.1 2025881 D 585034 CDS YP_002387379.1 218554466 7125220 complement(2026489..2026881) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8002587, 1482109, 89181349; hypothetical protein 2026881 flhE 7125220 flhE Escherichia coli IAI1 hypothetical protein YP_002387379.1 2026489 R 585034 CDS YP_002387380.1 218554467 7127230 complement(2026881..2028959) 1 NC_011741.1 membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA 2028959 flhA 7127230 flhA Escherichia coli IAI1 flagellar biosynthesis protein FlhA YP_002387380.1 2026881 R 585034 CDS YP_002387381.1 218554468 7127226 complement(2028952..2030100) 1 NC_011741.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB 2030100 flhB 7127226 flhB Escherichia coli IAI1 flagellar biosynthesis protein FlhB YP_002387381.1 2028952 R 585034 CDS YP_002387382.1 218554469 7127227 complement(2030302..2030946) 1 NC_011741.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis regulator CheZ 2030946 cheZ 7127227 cheZ Escherichia coli IAI1 chemotaxis regulator CheZ YP_002387382.1 2030302 R 585034 CDS YP_002387383.1 218554470 7126314 complement(2030957..2031346) 1 NC_011741.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY 2031346 cheY 7126314 cheY Escherichia coli IAI1 chemotaxis regulatory protein CheY YP_002387383.1 2030957 R 585034 CDS YP_002387384.1 218554471 7126313 complement(2031361..2032410) 1 NC_011741.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase 2032410 cheB 7126313 cheB Escherichia coli IAI1 chemotaxis-specific methylesterase YP_002387384.1 2031361 R 585034 CDS YP_002387385.1 218554472 7126310 complement(2032413..2033273) 1 NC_011741.1 methylates the MCP; chemotaxis methyltransferase CheR 2033273 cheR 7126310 cheR Escherichia coli IAI1 chemotaxis methyltransferase CheR YP_002387385.1 2032413 R 585034 CDS YP_002387386.1 218554473 7126311 complement(2033292..2034893) 1 NC_011741.1 mediates taxis toward dipeptides; methyl-accepting protein IV 2034893 tap 7126311 tap Escherichia coli IAI1 methyl-accepting protein IV YP_002387386.1 2033292 R 585034 CDS YP_002387387.1 218554474 7126211 complement(2034939..2036600) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90094243, 92165727, 6305515, 9315712; Product type r : regulator; methyl-accepting chemotaxis protein II 2036600 tar 7126211 tar Escherichia coli IAI1 methyl-accepting chemotaxis protein II YP_002387387.1 2034939 R 585034 CDS YP_002387388.1 218554475 7124434 complement(2036745..2037248) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91126073, 91296802, 91317710, 2002011, 3510184; Product type r : regulator; purine-binding chemotaxis protein 2037248 cheW 7124434 cheW Escherichia coli IAI1 purine-binding chemotaxis protein YP_002387388.1 2036745 R 585034 CDS YP_002387389.1 218554476 7126312 complement(2037269..2039233) 1 NC_011741.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA 2039233 cheA 7126312 cheA Escherichia coli IAI1 chemotaxis protein CheA YP_002387389.1 2037269 R 585034 CDS YP_002387390.1 218554477 7126309 complement(2039238..2040164) 1 NC_011741.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB 2040164 motB 7126309 motB Escherichia coli IAI1 flagellar motor protein MotB YP_002387390.1 2039238 R 585034 CDS YP_002387391.1 218554478 7125831 complement(2040161..2041048) 1 NC_011741.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA 2041048 motA 7125831 motA Escherichia coli IAI1 flagellar motor protein MotA YP_002387391.1 2040161 R 585034 CDS YP_002387392.1 218554479 7124307 complement(2041175..2041753) 1 NC_011741.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC 2041753 flhC 7124307 flhC Escherichia coli IAI1 transcriptional activator FlhC YP_002387392.1 2041175 R 585034 CDS YP_002387393.1 218554480 7127228 complement(2041756..2042115) 1 NC_011741.1 with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD 2042115 flhD 7127228 flhD Escherichia coli IAI1 transcriptional activator FlhD YP_002387393.1 2041756 R 585034 CDS YP_002387394.1 218554481 7127229 2042886..2043314 1 NC_011741.1 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspC 2043314 yecG 7127229 yecG Escherichia coli IAI1 universal stress protein UspC YP_002387394.1 2042886 D 585034 CDS YP_002387395.1 218554482 7125210 complement(2043321..2044745) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92078100, 92121128, 93302496, 8045430; Product type e : enzyme; trehalose-6-phosphate synthase 2044745 otsA 7125210 otsA Escherichia coli IAI1 trehalose-6-phosphate synthase YP_002387395.1 2043321 R 585034 CDS YP_002387396.1 218554483 7125999 complement(2044720..2045520) 1 NC_011741.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase 2045520 otsB 7125999 otsB Escherichia coli IAI1 trehalose-6-phosphate phosphatase YP_002387396.1 2044720 R 585034 CDS YP_002387397.1 218554484 7126000 complement(2045687..2046676) 1 NC_011741.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter permease 2046676 araH 7126000 araH Escherichia coli IAI1 L-arabinose transporter permease YP_002387397.1 2045687 R 585034 CDS YP_002387398.1 218554485 7125782 complement(2046688..2048202) 1 NC_011741.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein 2048202 araG 7125782 araG Escherichia coli IAI1 L-arabinose transporter ATP-binding protein YP_002387398.1 2046688 R 585034 CDS YP_002387399.1 218554486 7125781 complement(2048272..2049261) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89255061, 90375534, 2445996, 326784, 326785, 6885805, 7031057, 9298646; Product type t : transporter; L-arabinose ABC transporter periplasmic-binding protein 2049261 araF 7125781 araF Escherichia coli IAI1 L-arabinose ABC transporter periplasmic-binding protein YP_002387399.1 2048272 R 585034 CDS YP_002387400.1 218554487 7125780 2050058..2050561 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative ferritin-like protein 2050561 yecI 7125780 yecI Escherichia coli IAI1 putative ferritin-like protein YP_002387400.1 2050058 D 585034 CDS YP_002387401.1 218554488 7125212 complement(2050640..2050891) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2050891 yecJ 7125212 yecJ Escherichia coli IAI1 hypothetical protein YP_002387401.1 2050640 R 585034 CDS YP_002387402.1 218554489 7126088 2051003..2051149 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2051149 7126088 ECIAI1_1988 Escherichia coli IAI1 hypothetical protein YP_002387402.1 2051003 D 585034 CDS YP_002387403.1 218554490 7126823 2051351..2051674 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2051674 yecR 7126823 yecR Escherichia coli IAI1 hypothetical protein YP_002387403.1 2051351 D 585034 CDS YP_002387404.1 218554491 7125218 2051845..2052342 1 NC_011741.1 cytoplasmic iron storage protein; ferritin 2052342 ftn 7125218 ftn Escherichia coli IAI1 ferritin YP_002387404.1 2051845 D 585034 CDS YP_002387405.1 218554492 7128231 complement(2052380..2052619) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2052619 yecH 7128231 yecH Escherichia coli IAI1 hypothetical protein YP_002387405.1 2052380 R 585034 CDS YP_002387406.1 218554493 7125211 2052810..2054021 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89008121, 2022620; Product type t : transporter; tyrosine transporter 2054021 tyrP 7125211 tyrP Escherichia coli IAI1 tyrosine transporter YP_002387406.1 2052810 D 585034 CDS YP_002387407.1 218554494 7127527 complement(2054083..2054748) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2054748 yecA 7127527 yecA Escherichia coli IAI1 hypothetical protein YP_002387407.1 2054083 R 585034 CDS YP_002387408.1 218554495 7128052 complement(2055398..2055946) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 381294, 7007311, 94253011, 1323047, 3003065, 8917447; Product type e : enzyme; phosphatidylglycerophosphate synthetase 2055946 pgsA 7128052 pgsA Escherichia coli IAI1 phosphatidylglycerophosphate synthetase YP_002387408.1 2055398 R 585034 CDS YP_002387409.1 218554496 7124191 complement(2056003..2057835) 1 NC_011741.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 2057835 uvrC 7124191 uvrC Escherichia coli IAI1 excinuclease ABC subunit C YP_002387409.1 2056003 R 585034 CDS YP_002387410.1 218554497 7125557 complement(2057832..2058488) 1 NC_011741.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator 2058488 uvrY 7125557 uvrY Escherichia coli IAI1 response regulator YP_002387410.1 2057832 R 585034 CDS YP_002387411.1 218554498 7125559 2058784..2058960 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 2058960 7125559 ECIAI1_1999 Escherichia coli IAI1 hypothetical protein YP_002387411.1 2058784 D 585034 CDS YP_002387412.1 218554499 7126824 2058947..2059171 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3515318, 7567469; hypothetical protein 2059171 yecF 7126824 yecF Escherichia coli IAI1 hypothetical protein YP_002387412.1 2058947 D 585034 CDS YP_002387413.1 218554500 7125209 complement(2059238..2059960) 1 NC_011741.1 regulates genes involved in cell division; DNA-binding transcriptional activator SdiA 2059960 sdiA 7125209 sdiA Escherichia coli IAI1 DNA-binding transcriptional activator SdiA YP_002387413.1 2059238 R 585034 CDS YP_002387414.1 218554501 7124690 complement(2060190..2060942) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino-acid ABC transporter ATP-binding protein YecC 2060942 yecC 7124690 yecC Escherichia coli IAI1 putative amino-acid ABC transporter ATP-binding protein YecC YP_002387414.1 2060190 R 585034 CDS YP_002387415.1 218554502 7125206 complement(2060939..2061607) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease 2061607 yecS 7125206 yecS Escherichia coli IAI1 putative ABC transporter permease YP_002387415.1 2060939 R 585034 CDS YP_002387416.1 218554503 7125219 complement(2061622..2062608) 1 NC_011741.1 catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase 2062608 yedO 7125219 yedO Escherichia coli IAI1 D-cysteine desulfhydrase YP_002387416.1 2061622 R 585034 CDS YP_002387417.1 218554504 7125228 complement(2062713..2063513) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96125225, 8450713, 8774726, 9298646, 9740056; Product type t : transporter; cystine transporter subunit 2063513 fliY 7125228 fliY Escherichia coli IAI1 cystine transporter subunit YP_002387417.1 2062713 R 585034 CDS YP_002387418.1 218554505 7127250 complement(2063601..2064152) 1 NC_011741.1 expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence; flagella biosynthesis protein FliZ 2064152 fliZ 7127250 fliZ Escherichia coli IAI1 flagella biosynthesis protein FliZ YP_002387418.1 2063601 R 585034 CDS YP_002387419.1 218554506 7127251 complement(2064198..2064917) 1 NC_011741.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor 2064917 fliA 7127251 fliA Escherichia coli IAI1 flagellar biosynthesis sigma factor YP_002387419.1 2064198 R 585034 CDS YP_002387420.1 218554507 7127231 2064991..2065110 1 NC_011741.1 hypothetical protein 2065110 7127231 ECIAI1_2008 Escherichia coli IAI1 hypothetical protein YP_002387420.1 2064991 D 585034 CDS YP_002387421.1 218554508 7126825 complement(2065237..2067069) 1 NC_011741.1 structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes; flagellin 2067069 fliC 7126825 fliC Escherichia coli IAI1 flagellin YP_002387421.1 2065237 R 585034 CDS YP_002387422.1 218554509 7127232 2067335..2068741 1 NC_011741.1 involved in flagellin assembly; flagellar capping protein 2068741 fliD 7127232 fliD Escherichia coli IAI1 flagellar capping protein YP_002387422.1 2067335 D 585034 CDS YP_002387423.1 218554510 7127233 2068766..2069176 1 NC_011741.1 flagellin specific chaperone; flagellar protein FliS 2069176 fliS 7127233 fliS Escherichia coli IAI1 flagellar protein FliS YP_002387423.1 2068766 D 585034 CDS YP_002387424.1 218554511 7127248 2069176..2069541 1 NC_011741.1 binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT 2069541 fliT 7127248 fliT Escherichia coli IAI1 flagellar biosynthesis protein FliT YP_002387424.1 2069176 D 585034 CDS YP_002387425.1 218554512 7127249 2069619..2071106 1 NC_011741.1 converts 1,4-alpha-D-glucans to maltodextrin; cytoplasmic alpha-amylase 2071106 amyA 7127249 amyA Escherichia coli IAI1 cytoplasmic alpha-amylase YP_002387425.1 2069619 D 585034 CDS YP_002387426.1 218554513 7125762 complement(2071140..2071553) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2071553 yedD 7125762 yedD Escherichia coli IAI1 hypothetical protein YP_002387426.1 2071140 R 585034 CDS YP_002387427.1 218554514 7125222 2071740..2072945 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2072945 yedE 7125222 yedE Escherichia coli IAI1 hypothetical protein YP_002387427.1 2071740 D 585034 CDS YP_002387428.1 218554515 7125223 2072942..2073175 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2073175 yedF 7125223 yedF Escherichia coli IAI1 hypothetical protein YP_002387428.1 2072942 D 585034 CDS YP_002387429.1 218554516 7125224 2073282..2073950 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2073950 yedK 7125224 yedK Escherichia coli IAI1 hypothetical protein YP_002387429.1 2073282 D 585034 CDS YP_002387430.1 218554517 7125227 complement(2074343..2074657) 1 NC_011741.1 forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE 2074657 fliE 7125227 fliE Escherichia coli IAI1 flagellar hook-basal body protein FliE YP_002387430.1 2074343 R 585034 CDS YP_002387431.1 218554518 7127234 2074872..2076530 1 NC_011741.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein 2076530 fliF 7127234 fliF Escherichia coli IAI1 flagellar MS-ring protein YP_002387431.1 2074872 D 585034 CDS YP_002387432.1 218554519 7127235 2076523..2077518 1 NC_011741.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 2077518 fliG 7127235 fliG Escherichia coli IAI1 flagellar motor switch protein G YP_002387432.1 2076523 D 585034 CDS YP_002387433.1 218554520 7127236 2077511..2078197 1 NC_011741.1 binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 2078197 fliH 7127236 fliH Escherichia coli IAI1 flagellar assembly protein H YP_002387433.1 2077511 D 585034 CDS YP_002387434.1 218554521 7127237 2078197..2079570 1 NC_011741.1 involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 2079570 fliI 7127237 fliI Escherichia coli IAI1 flagellum-specific ATP synthase YP_002387434.1 2078197 D 585034 CDS YP_002387435.1 218554522 7127238 2079589..2080032 1 NC_011741.1 rod/hook and filament chaperone; flagellar biosynthesis chaperone 2080032 fliJ 7127238 fliJ Escherichia coli IAI1 flagellar biosynthesis chaperone YP_002387435.1 2079589 D 585034 CDS YP_002387436.1 218554523 7127239 2080029..2081156 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1482109, 8631687; Product type s : structure; flagellar hook-length control protein 2081156 fliK 7127239 fliK Escherichia coli IAI1 flagellar hook-length control protein YP_002387436.1 2080029 D 585034 CDS YP_002387437.1 218554524 7127240 2081261..2081725 1 NC_011741.1 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body-associated protein FliL 2081725 fliL 7127240 fliL Escherichia coli IAI1 flagellar basal body-associated protein FliL YP_002387437.1 2081261 D 585034 CDS YP_002387438.1 218554525 7127241 2081730..2082734 1 NC_011741.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 2082734 fliM 7127241 fliM Escherichia coli IAI1 flagellar motor switch protein FliM YP_002387438.1 2081730 D 585034 CDS YP_002387439.1 218554526 7127242 2082731..2083144 1 NC_011741.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN 2083144 fliN 7127242 fliN Escherichia coli IAI1 flagellar motor switch protein FliN YP_002387439.1 2082731 D 585034 CDS YP_002387440.1 218554527 7127243 2083147..2083512 1 NC_011741.1 with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO 2083512 fliO 7127243 fliO Escherichia coli IAI1 flagellar biosynthesis protein FliO YP_002387440.1 2083147 D 585034 CDS YP_002387441.1 218554528 7127244 2083512..2084249 1 NC_011741.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 2084249 fliP 7127244 fliP Escherichia coli IAI1 flagellar biosynthesis protein FliP YP_002387441.1 2083512 D 585034 CDS YP_002387442.1 218554529 7127245 2084259..2084528 1 NC_011741.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ 2084528 fliQ 7127245 fliQ Escherichia coli IAI1 flagellar biosynthesis protein FliQ YP_002387442.1 2084259 D 585034 CDS YP_002387443.1 218554530 7127246 2084536..2085321 1 NC_011741.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR 2085321 fliR 7127246 fliR Escherichia coli IAI1 flagellar biosynthesis protein FliR YP_002387443.1 2084536 D 585034 CDS YP_002387444.1 218554531 7127247 2085611..2086234 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14514676, 14766922, 20167175, 90130299, 91154130, 92048476, 9882673, 7534408; Product type r : regulator; DNA-binding transcriptional activator, co-regulator with RcsB 2086234 rcsA 7127247 rcsA Escherichia coli IAI1 DNA-binding transcriptional activator, co-regulator with RcsB YP_002387444.1 2085611 D 585034 CDS YP_002387445.1 218554532 7126598 complement(2086278..2086466) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 96324407, 7534408; hypothetical protein 2086466 dsrB 7126598 dsrB Escherichia coli IAI1 hypothetical protein YP_002387445.1 2086278 R 585034 CDS YP_002387446.1 218554533 7125030 2086629..2086856 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2086856 yodD 7125030 yodD Escherichia coli IAI1 hypothetical protein YP_002387446.1 2086629 D 585034 CDS YP_002387447.1 218554534 7125028 2087154..2087969 1 NC_011741.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate; mannosyl-3-phosphoglycerate phosphatase 2087969 yedP 7125028 yedP Escherichia coli IAI1 mannosyl-3-phosphoglycerate phosphatase YP_002387447.1 2087154 D 585034 CDS YP_002387448.1 218554535 7125229 complement(2087966..2089660) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16530465; Product type pe : putative enzyme; putative diguanylate cyclase 2089660 yedQ 7125229 yedQ Escherichia coli IAI1 putative diguanylate cyclase YP_002387448.1 2087966 R 585034 CDS YP_002387449.1 218554536 7125230 complement(2089581..2089769) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2089769 7125230 ECIAI1_2037 Escherichia coli IAI1 hypothetical protein YP_002387449.1 2089581 R 585034 CDS YP_002387450.1 218554537 7126826 complement(2089898..2090080) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2090080 yodC 7126826 yodC Escherichia coli IAI1 hypothetical protein YP_002387450.1 2089898 R 585034 CDS YP_002387451.1 218554538 7127600 complement(2090159..2091076) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2091076 yedI 7127600 yedI Escherichia coli IAI1 hypothetical protein YP_002387451.1 2090159 R 585034 CDS YP_002387452.1 218554539 7125225 2091249..2092169 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2092169 yedA 7125225 yedA Escherichia coli IAI1 hypothetical protein YP_002387452.1 2091249 D 585034 CDS YP_002387453.1 218554540 7125221 complement(2092158..2092628) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330522, 92049708, 94049122, 10360178, 10612397, 10871403, 2527357; Product type e : enzyme; DNA mismatch endonuclease of very short patch repair 2092628 vsr 7125221 vsr Escherichia coli IAI1 DNA mismatch endonuclease of very short patch repair YP_002387453.1 2092158 R 585034 CDS YP_002387454.1 218554541 7125571 complement(2092609..2094027) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90280700, 91285397, 93367813, 2198248, 2527357; Product type e : enzyme; DNA cytosine methylase 2094027 dcm 7125571 dcm Escherichia coli IAI1 DNA cytosine methylase YP_002387454.1 2092609 R 585034 CDS YP_002387455.1 218554542 7126923 complement(2094094..2094789) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pe : putative enzyme; hypothetical protein 2094789 yedJ 7126923 yedJ Escherichia coli IAI1 hypothetical protein YP_002387455.1 2094094 R 585034 CDS YP_002387456.1 218554543 7125226 complement(2094829..2095194) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2095194 yedR 7125226 yedR Escherichia coli IAI1 hypothetical protein YP_002387456.1 2094829 R 585034 CDS YP_002387457.1 218554544 7128435 2095731..2096948 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9642192; Product type m : membrane component; Porin OmpN 2096948 7128435 ECIAI1_2045 Escherichia coli IAI1 Porin OmpN YP_002387457.1 2095731 D 585034 CDS YP_002387458.1 218554545 7126827 2097541..2098392 1 NC_011741.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 2098392 hchA 7126827 hchA Escherichia coli IAI1 chaperone protein HchA YP_002387458.1 2097541 D 585034 CDS YP_002387459.1 218554546 7128495 complement(2098500..2099858) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15522865; Product type rc : receptor; sensory kinase in two-component regulatory system with YedW 2099858 yedV 7128495 yedV Escherichia coli IAI1 sensory kinase in two-component regulatory system with YedW YP_002387459.1 2098500 R 585034 CDS YP_002387460.1 218554547 7125232 complement(2099858..2100529) 1 NC_011741.1 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW 2100529 yedW 7125232 yedW Escherichia coli IAI1 transcriptional regulatory protein YedW YP_002387460.1 2099858 R 585034 CDS YP_002387461.1 218554548 7125233 2100662..2101075 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2101075 yedX 7125233 yedX Escherichia coli IAI1 hypothetical protein YP_002387461.1 2100662 D 585034 CDS YP_002387462.1 218554549 7125234 2101184..2102188 1 NC_011741.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; putative sulfite oxidase subunit YedY 2102188 yedY 7125234 yedY Escherichia coli IAI1 putative sulfite oxidase subunit YedY YP_002387462.1 2101184 D 585034 CDS YP_002387463.1 218554550 7125235 2102189..2102824 1 NC_011741.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; putative sulfite oxidase subunit YedZ 2102824 yedZ 7125235 yedZ Escherichia coli IAI1 putative sulfite oxidase subunit YedZ YP_002387463.1 2102189 D 585034 CDS YP_002387464.1 218554551 7125236 2103081..2103731 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12077457, 12480884, 12909634, 9579078; hypothetical protein 2103731 yodA 7125236 yodA Escherichia coli IAI1 hypothetical protein YP_002387464.1 2103081 D 585034 CDS YP_002387465.1 218554552 7127598 2104074..2104604 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16042411; Product type pc : putative carrier; putative cytochrome 2104604 yodB 7127598 yodB Escherichia coli IAI1 putative cytochrome YP_002387465.1 2104074 D 585034 CDS YP_002387466.1 218554553 7128051 2105356..2106153 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2106153 yeeI 7128051 yeeI Escherichia coli IAI1 hypothetical protein YP_002387466.1 2105356 D 585034 CDS YP_002387467.1 218554554 7126828 2106830..2113273 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659678; Product type f : factor; adhesin 2113273 yeeJ 7126828 yeeJ Escherichia coli IAI1 adhesin YP_002387467.1 2106830 D 585034 CDS YP_002387468.1 218554555 7125242 complement(2113270..2114136) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type h : extrachromosomal origin; IS3 element protein InsF 2114136 insF 7125242 insF Escherichia coli IAI1 IS3 element protein InsF YP_002387468.1 2113270 R 585034 CDS YP_002387469.1 218554556 7126070 complement(2114133..2114441) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type h : extrachromosomal origin; IS3 element protein InsE 2114441 insE 7126070 insE Escherichia coli IAI1 IS3 element protein InsE YP_002387469.1 2114133 R 585034 CDS YP_002387470.1 218554557 7126069 complement(2114904..2115956) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2115956 7126069 ECIAI1_2062 Escherichia coli IAI1 hypothetical protein YP_002387470.1 2114904 R 585034 CDS YP_002387471.1 218554558 7126829 2116271..2117587 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 5332864, 9524262; Product type t : transporter; shikimate transporter 2117587 shiA 7126829 shiA Escherichia coli IAI1 shikimate transporter YP_002387471.1 2116271 D 585034 CDS YP_002387472.1 218554559 7127928 2117689..2119143 1 NC_011741.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 2119143 amn 7127928 amn Escherichia coli IAI1 AMP nucleosidase YP_002387472.1 2117689 D 585034 CDS YP_002387473.1 218554560 7125755 2119486..2120202 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2120202 yeeN 7125755 yeeN Escherichia coli IAI1 hypothetical protein YP_002387473.1 2119486 D 585034 CDS YP_002387474.1 218554561 7125243 2120446..2120622 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 2120622 7125243 ECIAI1_2066 Escherichia coli IAI1 hypothetical protein YP_002387474.1 2120446 D 585034 CDS YP_002387475.1 218554562 7128050 complement(2120838..2122478) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16042411; Product type pt : putative transporter; hypothetical protein 2122478 yeeO 7128050 yeeO Escherichia coli IAI1 hypothetical protein YP_002387475.1 2120838 R 585034 CDS YP_002387476.1 218554563 7127992 complement(2122599..2123549) 1 NC_011741.1 LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl 2123549 cbl 7127992 cbl Escherichia coli IAI1 transcriptional regulator Cbl YP_002387476.1 2122599 R 585034 CDS YP_002387477.1 218554564 7124450 complement(2123651..2124568) 1 NC_011741.1 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator 2124568 nac 7124450 nac Escherichia coli IAI1 nitrogen assimilation transcriptional regulator YP_002387477.1 2123651 R 585034 CDS YP_002387478.1 218554565 7127993 complement(2125026..2125958) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9298646; hypothetical protein 2125958 erfK 7127993 erfK Escherichia coli IAI1 hypothetical protein YP_002387478.1 2125026 R 585034 CDS YP_002387479.1 218554566 7125089 complement(2126023..2127102) 1 NC_011741.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 2127102 cobT 7125089 cobT Escherichia coli IAI1 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase YP_002387479.1 2126023 R 585034 CDS YP_002387480.1 218554567 7126347 complement(2127114..2127857) 1 NC_011741.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 2127857 cobS 7126347 cobS Escherichia coli IAI1 cobalamin synthase YP_002387480.1 2127114 R 585034 CDS YP_002387481.1 218554568 7126346 complement(2127854..2128399) 1 NC_011741.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase 2128399 cobU 7126346 cobU Escherichia coli IAI1 adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase YP_002387481.1 2127854 R 585034 CDS YP_002387482.1 218554569 7126832 complement(2129268..2129663) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2129663 yeeX 7126832 yeeX Escherichia coli IAI1 hypothetical protein YP_002387482.1 2129268 R 585034 CDS YP_002387483.1 218554570 7125245 complement(2129769..2130827) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2130827 yeeA 7125245 yeeA Escherichia coli IAI1 hypothetical protein YP_002387483.1 2129769 R 585034 CDS YP_002387484.1 218554571 7125237 complement(2131026..2131499) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11850398, 9442027, 8709849; Product type r : regulator; DNA gyrase inhibitor 2131499 sbmC 7125237 sbmC Escherichia coli IAI1 DNA gyrase inhibitor YP_002387484.1 2131026 R 585034 CDS YP_002387485.1 218554572 7124679 complement(2131618..2132784) 1 NC_011741.1 removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 2132784 dacD 7124679 dacD Escherichia coli IAI1 D-alanyl-D-alanine carboxypeptidase YP_002387485.1 2131618 R 585034 CDS YP_002387486.1 218554573 7126911 2132973..2134400 1 NC_011741.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 2134400 sbcB 7126911 sbcB Escherichia coli IAI1 exonuclease I YP_002387486.1 2132973 D 585034 CDS YP_002387487.1 218554574 7124675 complement(2134443..2134670) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2134670 yeeD 7124675 yeeD Escherichia coli IAI1 hypothetical protein YP_002387487.1 2134443 R 585034 CDS YP_002387488.1 218554575 7125238 complement(2134684..2135742) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2135742 yeeE 7125238 yeeE Escherichia coli IAI1 hypothetical protein YP_002387488.1 2134684 R 585034 CDS YP_002387489.1 218554576 7125239 complement(2135921..2137279) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino-acid/amine transporter 2137279 yeeF 7125239 yeeF Escherichia coli IAI1 putative amino-acid/amine transporter YP_002387489.1 2135921 R 585034 CDS YP_002387490.1 218554577 7125240 complement(2137546..2138475) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2138475 yeeY 7125240 yeeY Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002387490.1 2137546 R 585034 CDS YP_002387491.1 218554578 7125246 complement(2138521..2139345) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative epimerase 2139345 yeeZ 7125246 yeeZ Escherichia coli IAI1 putative epimerase YP_002387491.1 2138521 R 585034 CDS YP_002387492.1 218554579 7125247 complement(2139428..2139682) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type f : factor; toxin of the YoeB-YefM toxin-antitoxin system 2139682 yoeB 7125247 yoeB Escherichia coli IAI1 toxin of the YoeB-YefM toxin-antitoxin system YP_002387492.1 2139428 R 585034 CDS YP_002387493.1 218554580 7127602 complement(2139679..2139930) 1 NC_011741.1 Antitoxin that counteracts the effect of the YoeB toxin; antitoxin YefM 2139930 yefM 7127602 yefM Escherichia coli IAI1 antitoxin YefM YP_002387493.1 2139679 R 585034 CDS YP_002387495.1 218554582 7125493 2140409..2141308 1 NC_011741.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2141308 hisG 7125493 hisG Escherichia coli IAI1 ATP phosphoribosyltransferase YP_002387495.1 2140409 D 585034 CDS YP_002387496.1 218554583 7125273 2141314..2142618 1 NC_011741.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2142618 hisD 7125273 hisD Escherichia coli IAI1 histidinol dehydrogenase YP_002387496.1 2141314 D 585034 CDS YP_002387497.1 218554584 7125271 2142615..2143685 1 NC_011741.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2143685 hisC 7125271 hisC Escherichia coli IAI1 histidinol-phosphate aminotransferase YP_002387497.1 2142615 D 585034 CDS YP_002387498.1 218554585 7125270 2143685..2144752 1 NC_011741.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2144752 hisB 7125270 hisB Escherichia coli IAI1 imidazole glycerol-phosphate dehydratase/histidinol phosphatase YP_002387498.1 2143685 D 585034 CDS YP_002387499.1 218554586 7125269 2144752..2145342 1 NC_011741.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2145342 hisH 7125269 hisH Escherichia coli IAI1 imidazole glycerol phosphate synthase subunit HisH YP_002387499.1 2144752 D 585034 CDS YP_002387500.1 218554587 7125274 2145342..2146079 1 NC_011741.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2146079 hisA 7125274 hisA Escherichia coli IAI1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase YP_002387500.1 2145342 D 585034 CDS YP_002387501.1 218554588 7125268 2146061..2146837 1 NC_011741.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2146837 hisF 7125268 hisF Escherichia coli IAI1 imidazole glycerol phosphate synthase subunit HisF YP_002387501.1 2146061 D 585034 CDS YP_002387502.1 218554589 7125272 2146831..2147439 1 NC_011741.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein 2147439 hisI 7125272 hisI Escherichia coli IAI1 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein YP_002387502.1 2146831 D 585034 CDS YP_002387503.1 218554590 7125275 complement(2147478..2148593) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10768928, 9370271, 9573168, 11964144, 4295288, 7536735; Product type e : enzyme; mannosyl transferase 2148593 wbdC 7125275 wbdC Escherichia coli IAI1 mannosyl transferase YP_002387503.1 2147478 R 585034 CDS YP_002387504.1 218554591 7125589 complement(2148603..2149760) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10768928, 7536735, 8162191; Product type e : enzyme; mannosyltransferase B 2149760 wbdB 7125589 wbdB Escherichia coli IAI1 mannosyltransferase B YP_002387504.1 2148603 R 585034 CDS YP_002387505.1 218554592 7125588 complement(2149812..2153453) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9573168, 10768928; Product type e : enzyme; mannosyltransferase 2153453 wbdA 7125588 wbdA Escherichia coli IAI1 mannosyltransferase YP_002387505.1 2149812 R 585034 CDS YP_002387506.1 218554593 7125587 complement(2153456..2154733) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9573168, 10768928; Product type pe : putative enzyme; putative SAM-dependent methyltransferase 2154733 wbbD 7125587 wbbD Escherichia coli IAI1 putative SAM-dependent methyltransferase YP_002387506.1 2153456 R 585034 CDS YP_002387507.1 218554594 7125586 complement(2154733..2155947) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10768928, 9573168, 9244257; Product type t : transporter; ATP binding component of ABC-transporter 2155947 wzt 7125586 wzt Escherichia coli IAI1 ATP binding component of ABC-transporter YP_002387507.1 2154733 R 585034 CDS YP_002387508.1 218554595 7126462 complement(2155947..2156741) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10768928, 9573168, 9244257; Product type m : membrane component; Integral membrane component of ABC-transporter 2156741 wzm 7126462 wzm Escherichia coli IAI1 Integral membrane component of ABC-transporter YP_002387508.1 2155947 R 585034 CDS YP_002387509.1 218554596 7126461 complement(2156743..2158149) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7515042, 9004408; Product type e : enzyme; phosphomannomutase (PMM) 2158149 cpsG 7126461 cpsG Escherichia coli IAI1 phosphomannomutase (PMM) YP_002387509.1 2156743 R 585034 CDS YP_002387510.1 218554597 7126358 complement(2158143..2159558) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7896702, 7515042, 9004408, 14993253; Product type e : enzyme; mannose-1-phosphate guanylyltransferase 2159558 cpsB 7126358 cpsB Escherichia coli IAI1 mannose-1-phosphate guanylyltransferase YP_002387510.1 2158143 R 585034 CDS YP_002387511.1 218554598 7126356 complement(2159840..2160148) 1 NC_011741.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2160148 7126356 ECIAI1_2105 Escherichia coli IAI1 hypothetical protein YP_002387511.1 2159840 R 585034 CDS YP_002387512.1 218554599 7126833 complement(2160321..2160704) 1 NC_011741.1 hypothetical protein 2160704 7126833 ECIAI1_2106 Escherichia coli IAI1 hypothetical protein YP_002387512.1 2160321 R 585034 CDS YP_002387513.1 218554600 7126834 complement(2160708..2161688) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98241528; Product type r : regulator; regulator of length of O-antigen component of lipopolysaccharide chains 2161688 cld 7126834 cld Escherichia coli IAI1 regulator of length of O-antigen component of lipopolysaccharide chains YP_002387513.1 2160708 R 585034 CDS YP_002387514.1 218554601 7126331 complement(2161831..2162997) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150218, 96326333; Product type e : enzyme; UDP-glucose 6-dehydrogenase 2162997 ugd 7126331 ugd Escherichia coli IAI1 UDP-glucose 6-dehydrogenase YP_002387514.1 2161831 R 585034 CDS YP_002387515.1 218554602 7125521 complement(2163245..2164651) 1 NC_011741.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 2164651 gnd 7125521 gnd Escherichia coli IAI1 6-phosphogluconate dehydrogenase YP_002387515.1 2163245 R 585034 CDS YP_002387516.1 218554603 7128365 complement(2164757..2165815) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyltransferase 2165815 7128365 ECIAI1_2110 Escherichia coli IAI1 putative glycosyltransferase YP_002387516.1 2164757 R 585034 CDS YP_002387517.1 218554604 7126835 complement(2165838..2166854) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative UDP-glucose 4-epimerase 2166854 7126835 ECIAI1_2111 Escherichia coli IAI1 putative UDP-glucose 4-epimerase YP_002387517.1 2165838 R 585034 CDS YP_002387518.1 218554605 7126836 complement(2166894..2167835) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane glycosyl transferase 2167835 7126836 ECIAI1_2112 Escherichia coli IAI1 putative membrane glycosyl transferase YP_002387518.1 2166894 R 585034 CDS YP_002387519.1 218554606 7126837 2168090..2168239 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 2168239 7126837 ECIAI1_2113 Escherichia coli IAI1 hypothetical protein YP_002387519.1 2168090 D 585034 CDS YP_002387520.1 218554607 7126838 complement(2169089..2170192) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2170192 7126838 ECIAI1_2114 Escherichia coli IAI1 hypothetical protein YP_002387520.1 2169089 R 585034 CDS YP_002387521.1 218554608 7126839 complement(2170189..2171553) 1 NC_011741.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2171553 7126839 ECIAI1_2115 Escherichia coli IAI1 hypothetical protein YP_002387521.1 2170189 R 585034 CDS YP_002387522.1 218554609 7126840 complement(2172982..2173872) 1 NC_011741.1 together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalF 2173872 galF 7126840 galF Escherichia coli IAI1 UTP--glucose-1-phosphate uridylyltransferase subunit GalF YP_002387522.1 2172982 R 585034 CDS YP_002387523.1 218554610 7128269 complement(2174115..2175110) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976290; Product type e : enzyme; UDP-N-acetylglucosamine 4-epimerase (UDP-GlcNAc 4-epimerase) 2175110 gne 7128269 gne Escherichia coli IAI1 UDP-N-acetylglucosamine 4-epimerase (UDP-GlcNAc 4-epimerase) YP_002387523.1 2174115 R 585034 CDS YP_002387524.1 218554611 7128366 complement(2175268..2176662) 1 NC_011741.1 WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid; putative colanic acid biosynthesis protein 2176662 wcaM 7128366 wcaM Escherichia coli IAI1 putative colanic acid biosynthesis protein YP_002387524.1 2175268 R 585034 CDS YP_002387525.1 218554612 7126456 complement(2176673..2177893) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme; putative glycosyl transferase 2177893 wcaL 7126456 wcaL Escherichia coli IAI1 putative glycosyl transferase YP_002387525.1 2176673 R 585034 CDS YP_002387526.1 218554613 7126455 complement(2177890..2179170) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333, 8759852, 11004393; Product type pe : putative enzyme; putative pyruvyl transferase 2179170 wcaK 7126455 wcaK Escherichia coli IAI1 putative pyruvyl transferase YP_002387526.1 2177890 R 585034 CDS YP_002387527.1 218554614 7126454 complement(2179735..2181213) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 8759852; Product type pt : putative transporter; colanic acid exporter 2181213 wzxC 7126454 wzxC Escherichia coli IAI1 colanic acid exporter YP_002387527.1 2179735 R 585034 CDS YP_002387528.1 218554615 7126463 complement(2181215..2182609) 1 NC_011741.1 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid; putative UDP-glucose lipid carrier transferase 2182609 wcaJ 7126463 wcaJ Escherichia coli IAI1 putative UDP-glucose lipid carrier transferase YP_002387528.1 2181215 R 585034 CDS YP_002387529.1 218554616 7126453 complement(2182664..2184034) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106949, 96326333, 7815923, 8759852; Product type e : enzyme; phosphomannomutase 2184034 cpsG 7126453 cpsG Escherichia coli IAI1 phosphomannomutase YP_002387529.1 2182664 R 585034 CDS YP_002387530.1 218554617 7126359 complement(2184227..2185663) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82100097, 85006781, 92048476, 93122523, 96326333, 7815923, 8759852; Product type e : enzyme; mannose-1-phosphate guanyltransferase 2185663 cpsB 7126359 cpsB Escherichia coli IAI1 mannose-1-phosphate guanyltransferase YP_002387530.1 2184227 R 585034 CDS YP_002387531.1 218554618 7126357 complement(2185666..2186889) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15670885, 96326333; Product type pe : putative enzyme; putative glycosyl transferase 2186889 wcaI 7126357 wcaI Escherichia coli IAI1 putative glycosyl transferase YP_002387531.1 2185666 R 585034 CDS YP_002387532.1 218554619 7126452 complement(2186886..2187365) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 10913267, 7592609, 7815923, 8759852; Product type e : enzyme; GDP-mannose mannosyl hydrolase 2187365 nudD 7126452 nudD Escherichia coli IAI1 GDP-mannose mannosyl hydrolase YP_002387532.1 2186886 R 585034 CDS YP_002387533.1 218554620 7125953 complement(2187368..2188333) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 98132401, 9862812, 7815923, 8759852, 9473059; Product type e : enzyme; bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase and GDP-4-dehydro-6-L-deoxygalactose reductase 2188333 fcl 7125953 fcl Escherichia coli IAI1 bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase and GDP-4-dehydro-6-L-deoxygalactose reductase YP_002387533.1 2187368 R 585034 CDS YP_002387534.1 218554621 7127071 complement(2188336..2189457) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20139699, 97400210, 10673432, 7815923, 8759852, 9257704, 14299611; Product type e : enzyme; GDP-D-mannose dehydratase 2189457 gmd 7127071 gmd Escherichia coli IAI1 GDP-D-mannose dehydratase YP_002387534.1 2188336 R 585034 CDS YP_002387535.1 218554622 7128361 complement(2189483..2190031) 1 NC_011741.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); putative colanic acid biosynthesis acetyltransferase WcaF 2190031 wcaF 7128361 wcaF Escherichia coli IAI1 putative colanic acid biosynthesis acetyltransferase WcaF YP_002387535.1 2189483 R 585034 CDS YP_002387536.1 218554623 7126451 complement(2190047..2190793) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11371548, 96326333, 8759852; Product type pe : putative enzyme; putative glycosyl transferase 2190793 wcaE 7126451 wcaE Escherichia coli IAI1 putative glycosyl transferase YP_002387536.1 2190047 R 585034 CDS YP_002387537.1 218554624 7126450 complement(2190804..2192021) 1 NC_011741.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance; putative colanic acid biosynthesis protein 2192021 wcaD 7126450 wcaD Escherichia coli IAI1 putative colanic acid biosynthesis protein YP_002387537.1 2190804 R 585034 CDS YP_002387538.1 218554625 7126449 complement(2191996..2193213) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme; putative glycosyl transferase 2193213 wcaC 7126449 wcaC Escherichia coli IAI1 putative glycosyl transferase YP_002387538.1 2191996 R 585034 CDS YP_002387539.1 218554626 7126448 complement(2193210..2193698) 1 NC_011741.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; putative colanic acid biosynthesis acetyltransferase WcaB 2193698 wcaB 7126448 wcaB Escherichia coli IAI1 putative colanic acid biosynthesis acetyltransferase WcaB YP_002387539.1 2193210 R 585034 CDS YP_002387540.1 218554627 7126447 complement(2193701..2194540) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme; putative glycosyl transferase 2194540 wcaA 7126447 wcaA Escherichia coli IAI1 putative glycosyl transferase YP_002387540.1 2193701 R 585034 CDS YP_002387541.1 218554628 7126969 complement(2194633..2196795) 1 NC_011741.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase 2196795 wzc 7126969 wzc Escherichia coli IAI1 tyrosine kinase YP_002387541.1 2194633 R 585034 CDS YP_002387542.1 218554629 7126460 complement(2196798..2197241) 1 NC_011741.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase 2197241 wzb 7126460 wzb Escherichia coli IAI1 tyrosine phosphatase YP_002387542.1 2196798 R 585034 CDS YP_002387543.1 218554630 7126459 complement(2197247..2198386) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15090537, 96326333, 8759852, 8763957; Product type lp : lipoprotein; lipoprotein required for capsular polysaccharide translocation through the outer membrane 2198386 wza 7126459 wza Escherichia coli IAI1 lipoprotein required for capsular polysaccharide translocation through the outer membrane YP_002387543.1 2197247 R 585034 CDS YP_002387544.1 218554631 7126458 2199045..2200628 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 2200628 yegH 7126458 yegH Escherichia coli IAI1 hypothetical protein YP_002387544.1 2199045 D 585034 CDS YP_002387545.1 218554632 7125251 complement(2200902..2202755) 1 NC_011741.1 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; putative assembly protein 2202755 asmA 7125251 asmA Escherichia coli IAI1 putative assembly protein YP_002387545.1 2200902 R 585034 CDS YP_002387546.1 218554633 7126260 complement(2202777..2203358) 1 NC_011741.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 2203358 dcd 7126260 dcd Escherichia coli IAI1 deoxycytidine triphosphate deaminase YP_002387546.1 2202777 R 585034 CDS YP_002387547.1 218554634 7126922 complement(2203450..2204091) 1 NC_011741.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 2204091 udk 7126922 udk Escherichia coli IAI1 uridine kinase YP_002387547.1 2203450 R 585034 CDS YP_002387548.1 218554635 7125519 2204409..2207726 1 NC_011741.1 contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction; putative sensor protein 2207726 yegE 7125519 yegE Escherichia coli IAI1 putative sensor protein YP_002387548.1 2204409 D 585034 CDS YP_002387549.1 218554636 7125250 complement(2207765..2208622) 1 NC_011741.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyl-adenine DNA glycosylase II 2208622 alkA 7125250 alkA Escherichia coli IAI1 3-methyl-adenine DNA glycosylase II YP_002387549.1 2207765 R 585034 CDS YP_002387550.1 218554637 7125743 2208756..2210108 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 6094528, 7940673, 7984428; Product type pf : putative factor; putative chaperone 2210108 yegD 7125743 yegD Escherichia coli IAI1 putative chaperone YP_002387550.1 2208756 D 585034 CDS YP_002387551.1 218554638 7125249 complement(2210120..2212069) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2212069 yegI 7125249 yegI Escherichia coli IAI1 hypothetical protein YP_002387551.1 2210120 R 585034 CDS YP_002387552.1 218554639 7125252 complement(2212057..2212818) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2212818 yegK 7125252 yegK Escherichia coli IAI1 hypothetical protein YP_002387552.1 2212057 R 585034 CDS YP_002387553.1 218554640 7125253 complement(2212815..2213474) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2213474 yegL 7125253 yegL Escherichia coli IAI1 hypothetical protein YP_002387553.1 2212815 R 585034 CDS YP_002387554.1 218554641 7125494 2214690..2215937 1 NC_011741.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtA 2215937 mdtA 7125494 mdtA Escherichia coli IAI1 multidrug efflux system subunit MdtA YP_002387554.1 2214690 D 585034 CDS YP_002387555.1 218554642 7127688 2215937..2219059 1 NC_011741.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtB 2219059 mdtB 7127688 mdtB Escherichia coli IAI1 multidrug efflux system subunit MdtB YP_002387555.1 2215937 D 585034 CDS YP_002387556.1 218554643 7127689 2219060..2222137 1 NC_011741.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC 2222137 mdtC 7127689 mdtC Escherichia coli IAI1 multidrug efflux system subunit MdtC YP_002387556.1 2219060 D 585034 CDS YP_002387557.1 218554644 7127690 2222138..2223553 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12107134, 21450803, 8282725; Product type t : transporter; multidrug efflux system protein MdtE 2223553 mdtD 7127690 mdtD Escherichia coli IAI1 multidrug efflux system protein MdtE YP_002387557.1 2222138 D 585034 CDS YP_002387558.1 218554645 7127691 2223550..2224953 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94110256, 8282725; Product type r : regulator; signal transduction histidine-protein kinase BaeS 2224953 baeS 7127691 baeS Escherichia coli IAI1 signal transduction histidine-protein kinase BaeS YP_002387558.1 2223550 D 585034 CDS YP_002387559.1 218554646 7126289 2224950..2225672 1 NC_011741.1 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; DNA-binding transcriptional regulator BaeR 2225672 baeR 7126289 baeR Escherichia coli IAI1 DNA-binding transcriptional regulator BaeR YP_002387559.1 2224950 D 585034 CDS YP_002387560.1 218554647 7126288 2225632..2225823 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 2225823 7126288 ECIAI1_2156 Escherichia coli IAI1 hypothetical protein YP_002387560.1 2225632 D 585034 CDS YP_002387561.1 218554648 7126841 2225863..2226195 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2226195 yegP 7126841 yegP Escherichia coli IAI1 hypothetical protein YP_002387561.1 2225863 D 585034 CDS YP_002387562.1 218554649 7125255 2226404..2226700 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2226700 7125255 ECIAI1_2158 Escherichia coli IAI1 hypothetical protein YP_002387562.1 2226404 D 585034 CDS YP_002387563.1 218554650 7126842 2226702..2226998 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2226998 7126842 ECIAI1_2159 Escherichia coli IAI1 hypothetical protein YP_002387563.1 2226702 D 585034 CDS YP_002387564.1 218554651 7126843 2227101..2228462 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 2228462 yegQ 7126843 yegQ Escherichia coli IAI1 putative peptidase YP_002387564.1 2227101 D 585034 CDS YP_002387565.1 218554652 7124656 complement(2228655..2228804) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2228804 7124656 ECIAI1_2161 Escherichia coli IAI1 hypothetical protein YP_002387565.1 2228655 R 585034 CDS YP_002387566.1 218554653 7126844 complement(2228792..2229109) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2229109 yegR 7126844 yegR Escherichia coli IAI1 hypothetical protein YP_002387566.1 2228792 R 585034 CDS YP_002387567.1 218554654 7125257 2229515..2230414 1 NC_011741.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase 2230414 yegS 7125257 yegS Escherichia coli IAI1 lipid kinase YP_002387567.1 2229515 D 585034 CDS YP_002387568.1 218554655 7125258 complement(2230496..2231275) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7772602; Product type r : regulator; Galactitol utilization operon repressor 2231275 gatR 7125258 gatR Escherichia coli IAI1 Galactitol utilization operon repressor YP_002387568.1 2230496 R 585034 CDS YP_002387569.1 218554656 7128288 complement(2231375..2232415) 1 NC_011741.1 Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase 2232415 gatD 7128288 gatD Escherichia coli IAI1 galactitol-1-phosphate dehydrogenase YP_002387569.1 2231375 R 585034 CDS YP_002387570.1 218554657 7128287 complement(2232463..2233818) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76024805, 77192083, 97113438, 7772602; Product type t : transporter; galactitol-specific PTS system transporter subunit IIC 2233818 gatC 7128287 gatC Escherichia coli IAI1 galactitol-specific PTS system transporter subunit IIC YP_002387570.1 2232463 R 585034 CDS YP_002387571.1 218554658 7128286 complement(2233822..2234106) 1 NC_011741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIB 2234106 gatB 7128286 gatB Escherichia coli IAI1 PTS system galactitol-specific transporter subunit IIB YP_002387571.1 2233822 R 585034 CDS YP_002387572.1 218554659 7128285 complement(2234137..2234589) 1 NC_011741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIA 2234589 gatA 7128285 gatA Escherichia coli IAI1 PTS system galactitol-specific transporter subunit IIA YP_002387572.1 2234137 R 585034 CDS YP_002387573.1 218554660 7128284 complement(2234599..2235861) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976750, 97113438, 7772602, 8932697; Product type e : enzyme; D-tagatose 1,6-bisphosphate aldolase 2 subunit 2235861 gatZ 7128284 gatZ Escherichia coli IAI1 D-tagatose 1,6-bisphosphate aldolase 2 subunit YP_002387573.1 2234599 R 585034 CDS YP_002387574.1 218554661 7128290 complement(2235890..2236744) 1 NC_011741.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 2236744 gatY 7128290 gatY Escherichia coli IAI1 tagatose-bisphosphate aldolase YP_002387574.1 2235890 R 585034 CDS YP_002387575.1 218554662 7128289 complement(2237054..2238106) 1 NC_011741.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase 2238106 fbaB 7128289 fbaB Escherichia coli IAI1 fructose-bisphosphate aldolase YP_002387575.1 2237054 R 585034 CDS YP_002387576.1 218554663 7127069 2238363..2239640 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative hydrophilic substrate MFS superfamily transporter 2239640 yegT 7127069 yegT Escherichia coli IAI1 putative hydrophilic substrate MFS superfamily transporter YP_002387576.1 2238363 D 585034 CDS YP_002387577.1 218554664 7125259 2239637..2240641 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative (phospho)hydrolase 2240641 yegU 7125259 yegU Escherichia coli IAI1 putative (phospho)hydrolase YP_002387577.1 2239637 D 585034 CDS YP_002387578.1 218554665 7125260 2240638..2241603 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative kinase 2241603 yegV 7125260 yegV Escherichia coli IAI1 putative kinase YP_002387578.1 2240638 D 585034 CDS YP_002387579.1 218554666 7125261 complement(2241577..2242323) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2242323 yegW 7125261 yegW Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002387579.1 2241577 R 585034 CDS YP_002387580.1 218554667 7125262 complement(2242375..2243193) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-bound hydrolase 2243193 yegX 7125262 yegX Escherichia coli IAI1 putative membrane-bound hydrolase YP_002387580.1 2242375 R 585034 CDS YP_002387581.1 218554668 7125263 complement(2243258..2244058) 1 NC_011741.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 2244058 thiD 7125263 thiD Escherichia coli IAI1 phosphomethylpyrimidine kinase YP_002387581.1 2243258 R 585034 CDS YP_002387582.1 218554669 7126241 complement(2244055..2244843) 1 NC_011741.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 2244843 thiM 7126241 thiM Escherichia coli IAI1 hydroxyethylthiazole kinase YP_002387582.1 2244055 R 585034 CDS YP_002387583.1 218554670 7125495 complement(2245066..2245338) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2245338 yohL 7125495 yohL Escherichia coli IAI1 hypothetical protein YP_002387583.1 2245066 R 585034 CDS YP_002387584.1 218554671 7127609 2245459..2246283 1 NC_011741.1 membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA 2246283 rncA 7127609 rncA Escherichia coli IAI1 nickel/cobalt efflux protein RcnA YP_002387584.1 2245459 D 585034 CDS YP_002387585.1 218554672 7125018 2246322..2246840 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2246840 yohN 7125018 yohN Escherichia coli IAI1 hypothetical protein YP_002387585.1 2246322 D 585034 CDS YP_002387586.1 218554673 7127610 complement(2246922..2247956) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative exported fimbrial-like adhesin protein 2247956 yehA 7127610 yehA Escherichia coli IAI1 putative exported fimbrial-like adhesin protein YP_002387586.1 2246922 R 585034 CDS YP_002387587.1 218554674 7125264 complement(2247970..2250450) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2250450 yehB 7125264 yehB Escherichia coli IAI1 hypothetical protein YP_002387587.1 2247970 R 585034 CDS YP_002387588.1 218554675 7125265 complement(2250466..2251140) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative membrane-associated pilin chaperone 2251140 yehC 7125265 yehC Escherichia coli IAI1 putative membrane-associated pilin chaperone YP_002387588.1 2250466 R 585034 CDS YP_002387589.1 218554676 7125266 complement(2251221..2251763) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein 2251763 yehD 7125266 yehD Escherichia coli IAI1 putative fimbrial-like adhesin protein YP_002387589.1 2251221 R 585034 CDS YP_002387590.1 218554677 7125267 complement(2252056..2252337) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2252337 yehE 7125267 yehE Escherichia coli IAI1 hypothetical protein YP_002387590.1 2252056 R 585034 CDS YP_002387591.1 218554678 7125106 complement(2252600..2253709) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91080852, 15601724, 2259334; Product type t : transporter; putative ATPase 2253709 mrp 7125106 mrp Escherichia coli IAI1 putative ATPase YP_002387591.1 2252600 R 585034 CDS YP_002387592.1 218554679 7124477 2253841..2255874 1 NC_011741.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 2255874 metG 7124477 metG Escherichia coli IAI1 methionyl-tRNA synthetase YP_002387592.1 2253841 D 585034 CDS YP_002387593.1 218554680 7124247 2256015..2259809 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2156810; Product type pr : putative regulator; putative Molybdate metabolism regulator (molR) 2259809 7124247 ECIAI1_2190 Escherichia coli IAI1 putative Molybdate metabolism regulator (molR) YP_002387593.1 2256015 D 585034 CDS YP_002387594.1 218554681 7126845 2259819..2263451 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2263451 yehI 7126845 yehI Escherichia coli IAI1 hypothetical protein YP_002387594.1 2259819 D 585034 CDS YP_002387595.1 218554682 7125108 2263512..2263832 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2263832 yehK 7125108 yehK Escherichia coli IAI1 hypothetical protein YP_002387595.1 2263512 D 585034 CDS YP_002387596.1 218554683 7125109 2265015..2266103 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16428726; Product type pf : putative factor; putative ABC superfamily protein 2266103 yehL 7125109 yehL Escherichia coli IAI1 putative ABC superfamily protein YP_002387596.1 2265015 D 585034 CDS YP_002387597.1 218554684 7125110 2266114..2268393 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2268393 yehM 7125110 yehM Escherichia coli IAI1 hypothetical protein YP_002387597.1 2266114 D 585034 CDS YP_002387598.1 218554685 7125111 2268386..2269522 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2269522 yehP 7125111 yehP Escherichia coli IAI1 hypothetical protein YP_002387598.1 2268386 D 585034 CDS YP_002387599.1 218554686 7125112 2269495..2271519 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2271519 yehQ 7125112 yehQ Escherichia coli IAI1 hypothetical protein YP_002387599.1 2269495 D 585034 CDS YP_002387600.1 218554687 7125113 2271644..2272105 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type lp : lipoprotein; hypothetical protein 2272105 yehR 7125113 yehR Escherichia coli IAI1 hypothetical protein YP_002387600.1 2271644 D 585034 CDS YP_002387601.1 218554688 7125114 complement(2272146..2272616) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2272616 yehS 7125114 yehS Escherichia coli IAI1 hypothetical protein YP_002387601.1 2272146 R 585034 CDS YP_002387602.1 218554689 7125115 complement(2272663..2273382) 1 NC_011741.1 unknown function; when overproduced it confers drug-resistance; putative two-component response-regulatory protein YehT 2273382 yehT 7125115 yehT Escherichia coli IAI1 putative two-component response-regulatory protein YehT YP_002387602.1 2272663 R 585034 CDS YP_002387603.1 218554690 7125116 complement(2273379..2275064) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15522865, 15322361; Product type rc : receptor; sensory kinase in two-component system with YehT 2275064 yehU 7125116 yehU Escherichia coli IAI1 sensory kinase in two-component system with YehT YP_002387603.1 2273379 R 585034 CDS YP_002387604.1 218554691 7125117 2275286..2276017 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11489123; Product type r : regulator; DNA-binding transcriptional regulator 2276017 mlrA 7125117 mlrA Escherichia coli IAI1 DNA-binding transcriptional regulator YP_002387604.1 2275286 D 585034 CDS YP_002387605.1 218554692 7124280 complement(2276014..2276205) 1 NC_011741.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2276205 7124280 ECIAI1_2204 Escherichia coli IAI1 hypothetical protein YP_002387605.1 2276014 R 585034 CDS YP_002387606.1 218554693 7126846 2276077..2276184 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2276184 yohO 7126846 yohO Escherichia coli IAI1 hypothetical protein YP_002387606.1 2276077 D 585034 CDS YP_002387607.1 218554694 7127611 complement(2276165..2276896) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease 2276896 yehW 7127611 yehW Escherichia coli IAI1 putative ABC transporter permease YP_002387607.1 2276165 R 585034 CDS YP_002387608.1 218554695 7125118 complement(2276901..2277827) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 2277827 yehX 7125118 yehX Escherichia coli IAI1 putative ABC transporter ATP-binding protein YP_002387608.1 2276901 R 585034 CDS YP_002387609.1 218554696 7125119 complement(2277820..2278977) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease 2278977 yehY 7125119 yehY Escherichia coli IAI1 putative ABC transporter permease YP_002387609.1 2277820 R 585034 CDS YP_002387610.1 218554697 7125120 complement(2278984..2279901) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15251200; Product type pt : putative transporter; putative ABC transporter periplasmic-binding protein 2279901 yehZ 7125120 yehZ Escherichia coli IAI1 putative ABC transporter periplasmic-binding protein YP_002387610.1 2278984 R 585034 CDS YP_002387611.1 218554698 7125121 complement(2280112..2282409) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96303506; Product type e : enzyme; beta-D-glucoside glucohydrolase, periplasmic 2282409 bglX 7125121 bglX Escherichia coli IAI1 beta-D-glucoside glucohydrolase, periplasmic YP_002387611.1 2280112 R 585034 CDS YP_002387612.1 218554699 7124406 2282605..2284320 1 NC_011741.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 2284320 dld 7124406 dld Escherichia coli IAI1 D-lactate dehydrogenase YP_002387612.1 2282605 D 585034 CDS YP_002387613.1 218554700 7124599 complement(2284358..2285290) 1 NC_011741.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase 2285290 pbpG 7124599 pbpG Escherichia coli IAI1 D-alanyl-D-alanine endopeptidase YP_002387613.1 2284358 R 585034 CDS YP_002387614.1 218554701 7124158 complement(2285464..2286051) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2286051 yohC 7124158 yohC Escherichia coli IAI1 hypothetical protein YP_002387614.1 2285464 R 585034 CDS YP_002387615.1 218554702 7127603 2286221..2286799 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2286799 yohD 7127603 yohD Escherichia coli IAI1 hypothetical protein YP_002387615.1 2286221 D 585034 CDS YP_002387616.1 218554703 7127604 complement(2286929..2287690) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; acetoin dehydrogenase 2287690 yohF 7127604 yohF Escherichia coli IAI1 acetoin dehydrogenase YP_002387616.1 2286929 R 585034 CDS YP_002387617.1 218554704 7127605 complement(2287743..2288831) 1 NC_011741.1 may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance outer membrane protein MdtQ 2288831 yohG 7127605 yohG Escherichia coli IAI1 multidrug resistance outer membrane protein MdtQ YP_002387617.1 2287743 R 585034 CDS YP_002387618.1 218554705 7127606 complement(2289859..2290806) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566; Product type e : enzyme; tRNA-dihydrouridine synthase C 2290806 dusC 7127606 dusC Escherichia coli IAI1 tRNA-dihydrouridine synthase C YP_002387618.1 2289859 R 585034 CDS YP_002387619.1 218554706 7125033 2291045..2291443 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2291443 yohJ 7125033 yohJ Escherichia coli IAI1 hypothetical protein YP_002387619.1 2291045 D 585034 CDS YP_002387620.1 218554707 7127607 2291440..2292135 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2292135 yohK 7127607 yohK Escherichia coli IAI1 hypothetical protein YP_002387620.1 2291440 D 585034 CDS YP_002387621.1 218554708 7127608 2292265..2293149 1 NC_011741.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2293149 cdd 7127608 cdd Escherichia coli IAI1 cytidine deaminase YP_002387621.1 2292265 D 585034 CDS YP_002387622.1 218554709 7126295 2293299..2294018 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 96125233, 1567863, 8550448; hypothetical protein 2294018 sanA 7126295 sanA Escherichia coli IAI1 hypothetical protein YP_002387622.1 2293299 D 585034 CDS YP_002387623.1 218554710 7124669 2294021..2294260 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2294260 yeiS 7124669 yeiS Escherichia coli IAI1 hypothetical protein YP_002387623.1 2294021 D 585034 CDS YP_002387624.1 218554711 7125134 2294579..2295817 1 NC_011741.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; putative oxidoreductase 2295817 yeiT 7125134 yeiT Escherichia coli IAI1 putative oxidoreductase YP_002387624.1 2294579 D 585034 CDS YP_002387625.1 218554712 7125135 2295811..2297046 1 NC_011741.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines; dihydropyrimidine dehydrogenase 2297046 yeiA 7125135 yeiA Escherichia coli IAI1 dihydropyrimidine dehydrogenase YP_002387625.1 2295811 D 585034 CDS YP_002387626.1 218554713 7125122 complement(2297117..2298127) 1 NC_011741.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane component 2298127 mglC 7125122 mglC Escherichia coli IAI1 beta-methylgalactoside transporter inner membrane component YP_002387626.1 2297117 R 585034 CDS YP_002387627.1 218554714 7124259 complement(2298143..2299663) 1 NC_011741.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein 2299663 mglA 7124259 mglA Escherichia coli IAI1 galactose/methyl galaxtoside transporter ATP-binding protein YP_002387627.1 2298143 R 585034 CDS YP_002387628.1 218554715 7124257 complement(2299724..2300722) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87286407, 92049246, 1719366, 3057628, 3302609, 3600760, 6340108, 6885805, 7012152, 9298646; Product type t : transporter; methyl-galactoside ABC transporter periplasmic-binding protein 2300722 mglB 7124257 mglB Escherichia coli IAI1 methyl-galactoside ABC transporter periplasmic-binding protein YP_002387628.1 2299724 R 585034 CDS YP_002387629.1 218554716 7124258 complement(2301002..2302042) 1 NC_011741.1 negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS 2302042 galS 7124258 galS Escherichia coli IAI1 DNA-binding transcriptional regulator GalS YP_002387629.1 2301002 R 585034 CDS YP_002387630.1 218554717 7128274 2302032..2302235 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2302235 7128274 ECIAI1_2229 Escherichia coli IAI1 hypothetical protein YP_002387630.1 2302032 D 585034 CDS YP_002387631.1 218554718 7126847 complement(2302184..2303341) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2303341 yeiB 7126847 yeiB Escherichia coli IAI1 hypothetical protein YP_002387631.1 2302184 R 585034 CDS YP_002387632.1 218554719 7125123 complement(2303358..2304026) 1 NC_011741.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 2304026 folE 7125123 folE Escherichia coli IAI1 GTP cyclohydrolase I YP_002387632.1 2303358 R 585034 CDS YP_002387633.1 218554720 7127263 2304180..2304356 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2304356 7127263 ECIAI1_2232 Escherichia coli IAI1 hypothetical protein YP_002387633.1 2304180 D 585034 CDS YP_002387634.1 218554721 7126848 2304284..2305120 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16567800; Product type e : enzyme; S-formylglutathione hydrolase 2305120 frmC 7126848 frmC Escherichia coli IAI1 S-formylglutathione hydrolase YP_002387634.1 2304284 D 585034 CDS YP_002387635.1 218554722 7127282 complement(2305152..2307143) 1 NC_011741.1 Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein; colicin I receptor 2307143 cirA 7127282 cirA Escherichia coli IAI1 colicin I receptor YP_002387635.1 2305152 R 585034 CDS YP_002387636.1 218554723 7126319 complement(2307136..2307339) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2307339 7126319 ECIAI1_2235 Escherichia coli IAI1 hypothetical protein YP_002387636.1 2307136 R 585034 CDS YP_002387637.1 218554724 7127287 complement(2307436..2308905) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92250419, 94252996, 1315732, 7551055; Product type t : transporter; lysine transporter 2308905 lysP 7127287 lysP Escherichia coli IAI1 lysine transporter YP_002387637.1 2307436 R 585034 CDS YP_002387638.1 218554725 7127644 complement(2309110..2309991) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12400704, 1315732; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2309991 yeiE 7127644 yeiE Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002387638.1 2309110 R 585034 CDS YP_002387639.1 218554726 7125125 2310090..2311139 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2311139 yeiH 7125125 yeiH Escherichia coli IAI1 hypothetical protein YP_002387639.1 2310090 D 585034 CDS YP_002387640.1 218554727 7125126 2311213..2312070 1 NC_011741.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2312070 nfo 7125126 nfo Escherichia coli IAI1 endonuclease IV YP_002387640.1 2311213 D 585034 CDS YP_002387641.1 218554728 7127869 2312074..2313162 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2313162 yeiI 7127869 yeiI Escherichia coli IAI1 hypothetical protein YP_002387641.1 2312074 D 585034 CDS YP_002387642.1 218554729 7125127 complement(2313218..2314468) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sodium/proton nucleoside transporter 2314468 yeiJ 7125127 yeiJ Escherichia coli IAI1 putative sodium/proton nucleoside transporter YP_002387642.1 2313218 R 585034 CDS YP_002387643.1 218554730 7125128 complement(2314568..2315509) 1 NC_011741.1 Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 2315509 rihB 7125128 rihB Escherichia coli IAI1 ribonucleoside hydrolase 2 YP_002387643.1 2314568 R 585034 CDS YP_002387644.1 218554731 7124999 2315678..2316337 1 NC_011741.1 activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 2316337 yeiL 7124999 yeiL Escherichia coli IAI1 DNA-binding transcriptional activator YeiL YP_002387644.1 2315678 D 585034 CDS YP_002387645.1 218554732 7125129 complement(2316408..2317658) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sodium/proton nucleoside transporter 2317658 yeiM 7125129 yeiM Escherichia coli IAI1 putative sodium/proton nucleoside transporter YP_002387645.1 2316408 R 585034 CDS YP_002387646.1 218554733 7125130 complement(2317752..2318690) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2318690 yeiN 7125130 yeiN Escherichia coli IAI1 hypothetical protein YP_002387646.1 2317752 R 585034 CDS YP_002387647.1 218554734 7125131 complement(2318678..2319619) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2319619 yeiC 7125131 yeiC Escherichia coli IAI1 hypothetical protein YP_002387647.1 2318678 R 585034 CDS YP_002387648.1 218554735 7125124 complement(2320043..2321734) 1 NC_011741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunits IIBC 2321734 fruA 7125124 fruA Escherichia coli IAI1 PTS system fructose-specific transporter subunits IIBC YP_002387648.1 2320043 R 585034 CDS YP_002387649.1 218554736 7127286 complement(2321751..2322689) 1 NC_011741.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase 2322689 fruK 7127286 fruK Escherichia coli IAI1 1-phosphofructokinase YP_002387649.1 2321751 R 585034 CDS YP_002387650.1 218554737 7128219 complement(2322689..2323819) 1 NC_011741.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein 2323819 fruB 7128219 fruB Escherichia coli IAI1 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein YP_002387650.1 2322689 R 585034 CDS YP_002387651.1 218554738 7128218 complement(2323850..2323993) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 2323993 7128218 ECIAI1_2250 Escherichia coli IAI1 hypothetical protein YP_002387651.1 2323850 R 585034 CDS YP_002387652.1 218554739 7127695 2324187..2325368 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438463, 10209755; Product type t : transporter; lactose/glucose efflux system 2325368 setB 7127695 setB Escherichia coli IAI1 lactose/glucose efflux system YP_002387652.1 2324187 D 585034 CDS YP_002387653.1 218554740 7127913 complement(2325365..2325751) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2325751 7127913 ECIAI1_2252 Escherichia coli IAI1 hypothetical protein YP_002387653.1 2325365 R 585034 CDS YP_002387654.1 218554741 7127696 2325519..2326346 1 NC_011741.1 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 2326346 7127696 ECIAI1_2253 Escherichia coli IAI1 elongation factor P YP_002387654.1 2325519 D 585034 CDS YP_002387655.1 218554742 7127697 2326569..2328035 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar dehydrogenase 2328035 yeiQ 7127697 yeiQ Escherichia coli IAI1 putative sugar dehydrogenase YP_002387655.1 2326569 D 585034 CDS YP_002387656.1 218554743 7125132 2328153..2329139 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2329139 yeiR 7125132 yeiR Escherichia coli IAI1 hypothetical protein YP_002387656.1 2328153 D 585034 CDS YP_002387657.1 218554744 7125133 2329178..2329891 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15778224; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase 2329891 yeiU 7125133 yeiU Escherichia coli IAI1 undecaprenyl pyrophosphate phosphatase YP_002387657.1 2329178 D 585034 CDS YP_002387658.1 218554745 7125136 2330303..2330869 1 NC_011741.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance; putative outer membrane lipoprotein 2330869 spr 7125136 spr Escherichia coli IAI1 putative outer membrane lipoprotein YP_002387658.1 2330303 D 585034 CDS YP_002387659.1 218554746 7127964 2331050..2332606 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2332606 rtn 7127964 rtn Escherichia coli IAI1 hypothetical protein YP_002387659.1 2331050 D 585034 CDS YP_002387660.1 218554747 7124631 2332688..2334502 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide ABC transporter periplasmic-binding protein 2334502 yejA 7124631 yejA Escherichia coli IAI1 putative oligopeptide ABC transporter periplasmic-binding protein YP_002387660.1 2332688 D 585034 CDS YP_002387661.1 218554748 7125137 2334503..2335597 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide ABC transporter permease 2335597 yejB 7125137 yejB Escherichia coli IAI1 putative oligopeptide ABC transporter permease YP_002387661.1 2334503 D 585034 CDS YP_002387662.1 218554749 7125138 2335597..2336622 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide ABC transporter permease 2336622 yejE 7125138 yejE Escherichia coli IAI1 putative oligopeptide ABC transporter permease YP_002387662.1 2335597 D 585034 CDS YP_002387663.1 218554750 7125139 2336624..2338213 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative fused oligopeptideABC transporter ATP-binding protein 2338213 yejF 7125139 yejF Escherichia coli IAI1 putative fused oligopeptideABC transporter ATP-binding protein YP_002387663.1 2336624 D 585034 CDS YP_002387664.1 218554751 7125140 complement(2338217..2338561) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2338561 yejG 7125140 yejG Escherichia coli IAI1 hypothetical protein YP_002387664.1 2338217 R 585034 CDS YP_002387665.1 218554752 7125141 complement(2338893..2340083) 1 NC_011741.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system 2340083 bcr 7125141 bcr Escherichia coli IAI1 bicyclomycin/multidrug efflux system YP_002387665.1 2338893 R 585034 CDS YP_002387666.1 218554753 7124385 complement(2340111..2340806) 1 NC_011741.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A 2340806 rsuA 7124385 rsuA Escherichia coli IAI1 16S rRNA pseudouridylate synthase A YP_002387666.1 2340111 R 585034 CDS YP_002387667.1 218554754 7128446 2340955..2342715 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleic acid ATP-dependent helicase 2342715 yejH 7128446 yejH Escherichia coli IAI1 putative nucleic acid ATP-dependent helicase YP_002387667.1 2340955 D 585034 CDS YP_002387668.1 218554755 7125142 2342840..2343124 1 NC_011741.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 2343124 rplY 7125142 rplY Escherichia coli IAI1 50S ribosomal protein L25 YP_002387668.1 2342840 D 585034 CDS YP_002387669.1 218554756 7128386 complement(2343263..2344270) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99296598, 10368163; Product type f : factor; nucleoid-associated protein NdpA 2344270 yejK 7128386 yejK Escherichia coli IAI1 nucleoid-associated protein NdpA YP_002387669.1 2343263 R 585034 CDS YP_002387670.1 218554757 7125143 2344452..2344679 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2344679 yejL 7125143 yejL Escherichia coli IAI1 hypothetical protein YP_002387670.1 2344452 D 585034 CDS YP_002387671.1 218554758 7125144 2344699..2346459 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase, inner membrane-associated 2346459 yejM 7125144 yejM Escherichia coli IAI1 putative hydrolase, inner membrane-associated YP_002387671.1 2344699 D 585034 CDS YP_002387672.1 218554759 7127995 complement(2346589..2346750) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2346750 7127995 ECIAI1_2271 Escherichia coli IAI1 hypothetical protein YP_002387672.1 2346589 R 585034 CDS YP_002387673.1 218554760 7125147 complement(2349336..2349593) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 2349593 7125147 ECIAI1_2274 Escherichia coli IAI1 hypothetical protein YP_002387673.1 2349336 R 585034 CDS YP_002387674.1 218554761 7127699 2349625..2350272 1 NC_011741.1 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 2350272 narP 7127699 narP Escherichia coli IAI1 transcriptional regulator NarP YP_002387674.1 2349625 D 585034 CDS YP_002387675.1 218554762 7124541 complement(2350307..2351359) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 11756453, 12196152, 87260957, 91194558, 95362656, 9914305, 7635817; Product type pe : putative enzyme; heme lyase, CcmH subunit 2351359 ccmH 7124541 ccmH Escherichia coli IAI1 heme lyase, CcmH subunit YP_002387675.1 2350307 R 585034 CDS YP_002387676.1 218554763 7126293 complement(2351356..2351913) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 9716493, 9770295, 11256948, 11350062, 11843181, 7635817, 9537397; Product type e : enzyme; periplasmic thioredoxin of cytochrome c-type biogenesis 2351913 ccmG 7126293 ccmG Escherichia coli IAI1 periplasmic thioredoxin of cytochrome c-type biogenesis YP_002387676.1 2351356 R 585034 CDS YP_002387677.1 218554764 7126292 complement(2351910..2353853) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 11756453, 12196152, 87260957, 8842153, 91194558, 95362656, 9716493, 7635817; Product type e : enzyme; heme lyase, CcmF subunit 2353853 ccmF 7126292 ccmF Escherichia coli IAI1 heme lyase, CcmF subunit YP_002387677.1 2351910 R 585034 CDS YP_002387678.1 218554765 7126291 complement(2353850..2354329) 1 NC_011741.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 2354329 ccmE 7126291 ccmE Escherichia coli IAI1 cytochrome c-type biogenesis protein CcmE YP_002387678.1 2353850 R 585034 CDS YP_002387679.1 218554766 7126290 complement(2354326..2354535) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 95362656, 9716493, 7635817; Product type f : factor; cytochrome c biogenesis protein 2354535 ccmD 7126290 ccmD Escherichia coli IAI1 cytochrome c biogenesis protein YP_002387679.1 2354326 R 585034 CDS YP_002387680.1 218554767 7126180 complement(2354532..2355269) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 14532274, 21413853, 95362656, 7635817; Product type t : transporter; heme ABC transporter membrane protein 2355269 ccmC 7126180 ccmC Escherichia coli IAI1 heme ABC transporter membrane protein YP_002387680.1 2354532 R 585034 CDS YP_002387681.1 218554768 7124460 complement(2355311..2355973) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 95362656, 9716493, 7635817; Product type t : transporter; heme ABC transporter membrane protein 2355973 ccmB 7124460 ccmB Escherichia coli IAI1 heme ABC transporter membrane protein YP_002387681.1 2355311 R 585034 CDS YP_002387682.1 218554769 7124459 complement(2355970..2356593) 1 NC_011741.1 ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 2356593 ccmA 7124459 ccmA Escherichia coli IAI1 cytochrome c biogenesis protein CcmA YP_002387682.1 2355970 R 585034 CDS YP_002387683.1 218554770 7124458 complement(2356606..2357208) 1 NC_011741.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC 2357208 napC 7124458 napC Escherichia coli IAI1 cytochrome c-type protein NapC YP_002387683.1 2356606 R 585034 CDS YP_002387684.1 218554771 7124530 complement(2357218..2357667) 1 NC_011741.1 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit 2357667 napB 7124530 napB Escherichia coli IAI1 citrate reductase cytochrome c-type subunit YP_002387684.1 2357218 R 585034 CDS YP_002387685.1 218554772 7124529 complement(2357664..2358527) 1 NC_011741.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component 2358527 napH 7124529 napH Escherichia coli IAI1 quinol dehydrogenase membrane component YP_002387685.1 2357664 R 585034 CDS YP_002387686.1 218554773 7124534 complement(2358514..2359209) 1 NC_011741.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component 2359209 napG 7124534 napG Escherichia coli IAI1 quinol dehydrogenase periplasmic component YP_002387686.1 2358514 R 585034 CDS YP_002387687.1 218554774 7124533 complement(2359216..2361702) 1 NC_011741.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit 2361702 napA 7124533 napA Escherichia coli IAI1 nitrate reductase catalytic subunit YP_002387687.1 2359216 R 585034 CDS YP_002387688.1 218554775 7124528 complement(2361699..2361962) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96228696, 99395037; Product type f : factor; assembly protein for periplasmic nitrate reductase 2361962 napD 7124528 napD Escherichia coli IAI1 assembly protein for periplasmic nitrate reductase YP_002387688.1 2361699 R 585034 CDS YP_002387689.1 218554776 7124531 complement(2361952..2362446) 1 NC_011741.1 Predicted role in electron transfer to the periplasmic nitrate reductase protein NapA.; ferredoxin-type protein 2362446 napF 7124531 napF Escherichia coli IAI1 ferredoxin-type protein YP_002387689.1 2361952 R 585034 CDS YP_002387690.1 218554777 7124532 2362546..2362719 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2362719 7124532 ECIAI1_2292 Escherichia coli IAI1 hypothetical protein YP_002387690.1 2362546 D 585034 CDS YP_002387691.1 218554778 7127700 2362854..2363342 1 NC_011741.1 serine protease inhibitor, inhibits trypsin and other proteases; ecotin 2363342 eco 7127700 eco Escherichia coli IAI1 ecotin YP_002387691.1 2362854 D 585034 CDS YP_002387692.1 218554779 7125045 complement(2363491..2365137) 1 NC_011741.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 2365137 mqo 7125045 mqo Escherichia coli IAI1 malate:quinone oxidoreductase YP_002387692.1 2363491 R 585034 CDS YP_002387693.1 218554780 7124466 complement(2365355..2366998) 1 NC_011741.1 efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane component/ATP-binding component 2366998 yojI 7124466 yojI Escherichia coli IAI1 multidrug transporter membrane component/ATP-binding component YP_002387693.1 2365355 R 585034 CDS YP_002387694.1 218554781 7124227 complement(2367074..2367724) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12226668, 12517444, 12862460, 14527653, 87057220, 88151899, 92017669, 3536913, 3887409, 7928996; Product type e : enzyme; oxidative demethylase 2367724 alkB 7124227 alkB Escherichia coli IAI1 oxidative demethylase YP_002387694.1 2367074 R 585034 CDS YP_002387695.1 218554782 7125744 complement(2367724..2368788) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91073391, 93272965, 94252990; Product type r : regulator; fused DNA-binding transcriptional dual regulator ; O6-methylguanine-DNA methyltransferase 2368788 ada 7125744 ada Escherichia coli IAI1 fused DNA-binding transcriptional dual regulator ; O6-methylguanine-DNA methyltransferase YP_002387695.1 2367724 R 585034 CDS YP_002387696.1 218554783 7125714 complement(2368862..2369917) 1 NC_011741.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE 2369917 yojL 7125714 yojL Escherichia coli IAI1 thiamine biosynthesis lipoprotein ApbE YP_002387696.1 2368862 R 585034 CDS YP_002387697.1 218554784 7124308 complement(2370029..2371132) 1 NC_011741.1 allows for ions and hydrophilic solutes to cross the outer membrane; outer membrane porin protein C 2371132 ompC 7124308 ompC Escherichia coli IAI1 outer membrane porin protein C YP_002387697.1 2370029 R 585034 CDS YP_002387698.1 218554785 7124274 2371870..2374542 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11758943, 12864862, 21206231, 2404948, 7984428; Product type r : regulator; phosphotransfer intermediate protein in two-component regulatory system with RcsBC 2374542 rcsD 7124274 rcsD Escherichia coli IAI1 phosphotransfer intermediate protein in two-component regulatory system with RcsBC YP_002387698.1 2371870 D 585034 CDS YP_002387699.1 218554786 7126601 2374559..2375209 1 NC_011741.1 two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 2375209 rcsB 7126601 rcsB Escherichia coli IAI1 transcriptional regulator RcsB YP_002387699.1 2374559 D 585034 CDS YP_002387700.1 218554787 7126599 complement(2375409..2378210) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11758943, 12864862, 14651646, 20032358, 21450811, 88227838, 90130299, 92048476, 9209051, 2404948, 8366025; Product type r : regulator; hybrid sensory kinase in two-component regulatory system with RcsB and YojN 2378210 rcsC 7126599 rcsC Escherichia coli IAI1 hybrid sensory kinase in two-component regulatory system with RcsB and YojN YP_002387700.1 2375409 R 585034 CDS YP_002387701.1 218554788 7126600 complement(2378533..2379309) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2379309 yfaP 7126600 yfaP Escherichia coli IAI1 hypothetical protein YP_002387701.1 2378533 R 585034 CDS YP_002387702.1 218554789 7125154 complement(2379314..2380963) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2380963 yfaQ 7125154 yfaQ Escherichia coli IAI1 hypothetical protein YP_002387702.1 2379314 R 585034 CDS YP_002387703.1 218554790 7125155 complement(2380964..2385583) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative large extracellular alpha-helical protein 2385583 7125155 ECIAI1_2305 Escherichia coli IAI1 putative large extracellular alpha-helical protein YP_002387703.1 2380964 R 585034 CDS YP_002387704.1 218554791 7127701 complement(2385502..2386125) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2386125 yfaT 7127701 yfaT Escherichia coli IAI1 hypothetical protein YP_002387704.1 2385502 R 585034 CDS YP_002387705.1 218554792 7125156 complement(2386122..2387810) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2387810 yfaA 7125156 yfaA Escherichia coli IAI1 hypothetical protein YP_002387705.1 2386122 R 585034 CDS YP_002387706.1 218554793 7125148 complement(2387843..2387923) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 2387923 7125148 ECIAI1_2308 Escherichia coli IAI1 hypothetical protein YP_002387706.1 2387843 R 585034 CDS YP_002387707.1 218554794 7127702 complement(2387959..2390586) 1 NC_011741.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 2390586 gyrA 7127702 gyrA Escherichia coli IAI1 DNA gyrase subunit A YP_002387707.1 2387959 R 585034 CDS YP_002387708.1 218554795 7128485 2390733..2391455 1 NC_011741.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2391455 ubiG 7128485 ubiG Escherichia coli IAI1 3-demethylubiquinone-9 3-methyltransferase YP_002387708.1 2390733 D 585034 CDS YP_002387709.1 218554796 7125515 complement(2391583..2395317) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659678; Product type f : factor; adhesin 2395317 yfaL 7125515 yfaL Escherichia coli IAI1 adhesin YP_002387709.1 2391583 R 585034 CDS YP_002387710.1 218554797 7125152 2396013..2398298 1 NC_011741.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2398298 nrdA 7125152 nrdA Escherichia coli IAI1 ribonucleotide-diphosphate reductase subunit alpha YP_002387710.1 2396013 D 585034 CDS YP_002387711.1 218554798 7127900 2398387..2399517 1 NC_011741.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 2399517 nrdB 7127900 nrdB Escherichia coli IAI1 ribonucleotide-diphosphate reductase subunit beta YP_002387711.1 2398387 D 585034 CDS YP_002387712.1 218554799 7127901 2399517..2399771 1 NC_011741.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin YfaE 2399771 yfaE 7127901 yfaE Escherichia coli IAI1 2Fe-2S ferredoxin YfaE YP_002387712.1 2399517 D 585034 CDS YP_002387713.1 218554800 7125150 complement(2399825..2400475) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 92165728, 1537798, 6087316; hypothetical protein 2400475 inaA 7125150 inaA Escherichia coli IAI1 hypothetical protein YP_002387713.1 2399825 R 585034 CDS YP_002387714.1 218554801 7126063 2400690..2400896 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2400896 yfaH 7126063 yfaH Escherichia coli IAI1 hypothetical protein YP_002387714.1 2400690 D 585034 CDS YP_002387715.1 218554802 7125151 complement(2400938..2402014) 1 NC_011741.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase 2402014 glpQ 7125151 glpQ Escherichia coli IAI1 glycerophosphodiester phosphodiesterase YP_002387715.1 2400938 R 585034 CDS YP_002387716.1 218554803 7128342 complement(2402019..2403377) 1 NC_011741.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter 2403377 glpT 7128342 glpT Escherichia coli IAI1 sn-glycerol-3-phosphate transporter YP_002387716.1 2402019 R 585034 CDS YP_002387717.1 218554804 7128344 2403650..2405278 1 NC_011741.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 2405278 glpA 7128344 glpA Escherichia coli IAI1 sn-glycerol-3-phosphate dehydrogenase subunit A YP_002387717.1 2403650 D 585034 CDS YP_002387718.1 218554805 7128334 2405268..2406527 1 NC_011741.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 2406527 glpB 7128334 glpB Escherichia coli IAI1 anaerobic glycerol-3-phosphate dehydrogenase subunit B YP_002387718.1 2405268 D 585034 CDS YP_002387719.1 218554806 7128335 2406524..2407714 1 NC_011741.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 2407714 glpC 7128335 glpC Escherichia coli IAI1 sn-glycerol-3-phosphate dehydrogenase subunit C YP_002387719.1 2406524 D 585034 CDS YP_002387720.1 218554807 7128336 2407908..2408810 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2408810 yfaD 7128336 yfaD Escherichia coli IAI1 hypothetical protein YP_002387720.1 2407908 D 585034 CDS YP_002387721.1 218554808 7125157 complement(2409376..2410578) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A 2410578 yfaY 7125157 yfaY Escherichia coli IAI1 competence damage-inducible protein A YP_002387721.1 2409376 R 585034 CDS YP_002387722.1 218554809 7125158 complement(2410678..2411220) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane porin protein 2411220 yfaZ 7125158 yfaZ Escherichia coli IAI1 putative outer membrane porin protein YP_002387722.1 2410678 R 585034 CDS YP_002387723.1 218554810 7125159 2411499..2411924 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16430214; Product type pe : putative enzyme; putative NUDIX hydrolase 2411924 yfaO 7125159 yfaO Escherichia coli IAI1 putative NUDIX hydrolase YP_002387723.1 2411499 D 585034 CDS YP_002387724.1 218554811 7125153 complement(2411963..2412565) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2412565 ais 7125153 ais Escherichia coli IAI1 hypothetical protein YP_002387724.1 2411963 R 585034 CDS YP_002387725.1 218554812 7125739 2412855..2414012 1 NC_011741.1 catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 2414012 yfbE 7125739 yfbE Escherichia coli IAI1 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase YP_002387725.1 2412855 D 585034 CDS YP_002387726.1 218554813 7125161 2414016..2414984 1 NC_011741.1 catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 2414984 yfbF 7125161 yfbF Escherichia coli IAI1 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase YP_002387726.1 2414016 D 585034 CDS YP_002387727.1 218554814 7125162 2414984..2416966 1 NC_011741.1 Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 2416966 yfbG 7125162 yfbG Escherichia coli IAI1 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase YP_002387727.1 2414984 D 585034 CDS YP_002387728.1 218554815 7125163 2416963..2417853 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2417853 yfbH 7125163 yfbH Escherichia coli IAI1 hypothetical protein YP_002387728.1 2416963 D 585034 CDS YP_002387729.1 218554816 7125164 2417853..2419505 1 NC_011741.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 2419505 arnT 7125164 arnT Escherichia coli IAI1 4-amino-4-deoxy-L-arabinose transferase YP_002387729.1 2417853 D 585034 CDS YP_002387730.1 218554817 7125801 2419502..2419837 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2419837 yfbW 7125801 yfbW Escherichia coli IAI1 hypothetical protein YP_002387730.1 2419502 D 585034 CDS YP_002387731.1 218554818 7125173 2419555..2420223 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2420223 yfbJ 7125173 yfbJ Escherichia coli IAI1 hypothetical protein YP_002387731.1 2419555 D 585034 CDS YP_002387732.1 218554819 7125165 complement(2420217..2420483) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96015440, 15569938; Product type pt : putative transporter; polymyxin resistance protein B 2420483 pmrD 7125165 pmrD Escherichia coli IAI1 polymyxin resistance protein B YP_002387732.1 2420217 R 585034 CDS YP_002387733.1 218554820 7126104 complement(2420593..2421948) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96186953, 8626063; Product type e : enzyme; O-succinylbenzoic acid--CoA ligase 2421948 menE 7126104 menE Escherichia coli IAI1 O-succinylbenzoic acid--CoA ligase YP_002387733.1 2420593 R 585034 CDS YP_002387734.1 218554821 7124239 complement(2421945..2422907) 1 NC_011741.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 2422907 menC 7124239 menC Escherichia coli IAI1 O-succinylbenzoate synthase YP_002387734.1 2421945 R 585034 CDS YP_002387735.1 218554822 7124237 complement(2422907..2423764) 1 NC_011741.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 2423764 menB 7124237 menB Escherichia coli IAI1 naphthoate synthase YP_002387735.1 2422907 R 585034 CDS YP_002387736.1 218554823 7124236 complement(2423779..2424537) 1 NC_011741.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase YfbB 2424537 yfbB 7124236 yfbB Escherichia coli IAI1 acyl-CoA thioester hydrolase YfbB YP_002387736.1 2423779 R 585034 CDS YP_002387737.1 218554824 7125160 complement(2424534..2426204) 1 NC_011741.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 2426204 menD 7125160 menD Escherichia coli IAI1 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase YP_002387737.1 2424534 R 585034 CDS YP_002387738.1 218554825 7124238 complement(2426293..2427588) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150206, 96140724, 2666397, 7984428, 8549818, 8764478; Product type e : enzyme; isochorismate synthase 2 2427588 menF 7124238 menF Escherichia coli IAI1 isochorismate synthase 2 YP_002387738.1 2426293 R 585034 CDS YP_002387739.1 218554826 7124240 complement(2427667..2427972) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2427972 elaB 7124240 elaB Escherichia coli IAI1 hypothetical protein YP_002387739.1 2427667 R 585034 CDS YP_002387740.1 218554827 7125056 complement(2428027..2428488) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2428488 elaA 7125056 elaA Escherichia coli IAI1 hypothetical protein YP_002387740.1 2428027 R 585034 CDS YP_002387741.1 218554828 7125055 2428553..2429470 1 NC_011741.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2429470 elaC 7125055 elaC Escherichia coli IAI1 ribonuclease Z YP_002387741.1 2428553 D 585034 CDS YP_002387742.1 218554829 7125057 2429658..2430878 1 NC_011741.1 ElaD; specific cysteine protease which targets ubiquitin and ubiquitin-like proteins covalently bound to target proteins; SseL in Salmonella is required for macrophage killing and virulence, and it is secreted by the salmonella pathogenicity island 2 type III secretion system; deubiquitinase 2430878 elaD 7125057 elaD Escherichia coli IAI1 deubiquitinase YP_002387742.1 2429658 D 585034 CDS YP_002387743.1 218554830 7125058 2431523..2431873 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2431873 7125058 ECIAI1_2348 Escherichia coli IAI1 hypothetical protein YP_002387743.1 2431523 D 585034 CDS YP_002387744.1 218554831 7127703 2431999..2432502 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2432502 yfbM 7127703 yfbM Escherichia coli IAI1 hypothetical protein YP_002387744.1 2431999 D 585034 CDS YP_002387745.1 218554832 7125166 complement(2432569..2434026) 1 NC_011741.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 2434026 nuoN 7125166 nuoN Escherichia coli IAI1 NADH dehydrogenase subunit N YP_002387745.1 2432569 R 585034 CDS YP_002387746.1 218554833 7125970 complement(2434033..2435562) 1 NC_011741.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 2435562 nuoM 7125970 nuoM Escherichia coli IAI1 NADH dehydrogenase subunit M YP_002387746.1 2434033 R 585034 CDS YP_002387747.1 218554834 7125969 complement(2435726..2437567) 1 NC_011741.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 2437567 nuoL 7125969 nuoL Escherichia coli IAI1 NADH dehydrogenase subunit L YP_002387747.1 2435726 R 585034 CDS YP_002387748.1 218554835 7125968 complement(2437564..2437866) 1 NC_011741.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 2437866 nuoK 7125968 nuoK Escherichia coli IAI1 NADH dehydrogenase subunit K YP_002387748.1 2437564 R 585034 CDS YP_002387749.1 218554836 7125967 complement(2437863..2438417) 1 NC_011741.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 2438417 nuoJ 7125967 nuoJ Escherichia coli IAI1 NADH dehydrogenase subunit J YP_002387749.1 2437863 R 585034 CDS YP_002387750.1 218554837 7125966 complement(2438429..2438971) 1 NC_011741.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 2438971 nuoI 7125966 nuoI Escherichia coli IAI1 NADH dehydrogenase subunit I YP_002387750.1 2438429 R 585034 CDS YP_002387751.1 218554838 7125965 complement(2438986..2439963) 1 NC_011741.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 2439963 nuoH 7125965 nuoH Escherichia coli IAI1 NADH dehydrogenase subunit H YP_002387751.1 2438986 R 585034 CDS YP_002387752.1 218554839 7125964 complement(2439960..2442692) 1 NC_011741.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 2442692 nuoG 7125964 nuoG Escherichia coli IAI1 NADH dehydrogenase subunit G YP_002387752.1 2439960 R 585034 CDS YP_002387753.1 218554840 7125963 complement(2442739..2444076) 1 NC_011741.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F 2444076 nuoF 7125963 nuoF Escherichia coli IAI1 NADH dehydrogenase I subunit F YP_002387753.1 2442739 R 585034 CDS YP_002387754.1 218554841 7125962 complement(2444073..2444573) 1 NC_011741.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 2444573 nuoE 7125962 nuoE Escherichia coli IAI1 NADH dehydrogenase subunit E YP_002387754.1 2444073 R 585034 CDS YP_002387755.1 218554842 7125961 complement(2444576..2446378) 1 NC_011741.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D 2446378 nuoC 7125961 nuoC Escherichia coli IAI1 bifunctional NADH:ubiquinone oxidoreductase subunit C/D YP_002387755.1 2444576 R 585034 CDS YP_002387756.1 218554843 7125960 complement(2446472..2447134) 1 NC_011741.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 2447134 nuoB 7125960 nuoB Escherichia coli IAI1 NADH dehydrogenase subunit B YP_002387756.1 2446472 R 585034 CDS YP_002387757.1 218554844 7125959 complement(2447150..2447593) 1 NC_011741.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 2447593 nuoA 7125959 nuoA Escherichia coli IAI1 NADH dehydrogenase subunit A YP_002387757.1 2447150 R 585034 CDS YP_002387758.1 218554845 7125958 complement(2448224..2449162) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123461, 9882671, 7565112; Product type r : regulator; DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes 2449162 lrhA 7125958 lrhA Escherichia coli IAI1 DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes YP_002387758.1 2448224 R 585034 CDS YP_002387759.1 218554846 7127630 2450082..2451299 1 NC_011741.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 2451299 yfbQ 7127630 yfbQ Escherichia coli IAI1 aminotransferase AlaT YP_002387759.1 2450082 D 585034 CDS YP_002387760.1 218554847 7125167 2451383..2451982 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15489502; Product type e : enzyme; hypothetical protein 2451982 yfbR 7125167 yfbR Escherichia coli IAI1 hypothetical protein YP_002387760.1 2451383 D 585034 CDS YP_002387761.1 218554848 7125168 complement(2452041..2453873) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 2453873 yfbS 7125168 yfbS Escherichia coli IAI1 putative transporter YP_002387761.1 2452041 R 585034 CDS YP_002387762.1 218554849 7125169 complement(2453960..2454610) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphatase 2454610 yfbT 7125169 yfbT Escherichia coli IAI1 putative phosphatase YP_002387762.1 2453960 R 585034 CDS YP_002387763.1 218554850 7125170 complement(2454621..2455115) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2455115 yfbU 7125170 yfbU Escherichia coli IAI1 hypothetical protein YP_002387763.1 2454621 R 585034 CDS YP_002387764.1 218554851 7125171 complement(2455198..2455653) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2455653 yfbV 7125171 yfbV Escherichia coli IAI1 hypothetical protein YP_002387764.1 2455198 R 585034 CDS YP_002387765.1 218554852 7125172 2455821..2455982 1 NC_011741.1 hypothetical protein 2455982 7125172 ECIAI1_2370 Escherichia coli IAI1 hypothetical protein YP_002387765.1 2455821 D 585034 CDS YP_002387766.1 218554853 7127704 2455991..2457193 1 NC_011741.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2457193 ackA 7127704 ackA Escherichia coli IAI1 acetate kinase YP_002387766.1 2455991 D 585034 CDS YP_002387767.1 218554854 7125699 2457268..2459412 1 NC_011741.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 2459412 pta 7125699 pta Escherichia coli IAI1 phosphate acetyltransferase YP_002387767.1 2457268 D 585034 CDS YP_002387768.1 218554855 7125176 complement(2461154..2461696) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16430214; Product type pe : putative enzyme; putative NUDIX hydrolase 2461696 yfcD 7125176 yfcD Escherichia coli IAI1 putative NUDIX hydrolase YP_002387768.1 2461154 R 585034 CDS YP_002387769.1 218554856 7125177 complement(2461754..2462308) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; phosphodiesterase 2462308 yfcE 7125177 yfcE Escherichia coli IAI1 phosphodiesterase YP_002387769.1 2461754 R 585034 CDS YP_002387770.1 218554857 7125178 complement(2462361..2463005) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2463005 yfcF 7125178 yfcF Escherichia coli IAI1 hypothetical protein YP_002387770.1 2462361 R 585034 CDS YP_002387771.1 218554858 7125179 2463141..2463788 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; glutathione S-transferase 2463788 yfcG 7125179 yfcG Escherichia coli IAI1 glutathione S-transferase YP_002387771.1 2463141 D 585034 CDS YP_002387772.1 218554859 7125180 2463845..2464207 1 NC_011741.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 2464207 folX 7125180 folX Escherichia coli IAI1 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase YP_002387772.1 2463845 D 585034 CDS YP_002387773.1 218554860 7127267 2464228..2465121 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : putative enzyme; hypothetical protein 2465121 yfcH 7127267 yfcH Escherichia coli IAI1 hypothetical protein YP_002387773.1 2464228 D 585034 CDS YP_002387774.1 218554861 7125181 complement(2465169..2466071) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase 2466071 yfcI 7125181 yfcI Escherichia coli IAI1 putative transposase YP_002387774.1 2465169 R 585034 CDS YP_002387775.1 218554862 7125182 complement(2466268..2467041) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 3313284, 91060556; Product type t : transporter; histidine/lysine/arginine/ornithine transporter subunit 2467041 hisP 7125182 hisP Escherichia coli IAI1 histidine/lysine/arginine/ornithine transporter subunit YP_002387775.1 2466268 R 585034 CDS YP_002387776.1 218554863 7125279 complement(2467049..2467765) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 3313284; Product type t : transporter; histidine/lysine/arginine/ornithine ABC transporter membrane protein 2467765 hisM 7125279 hisM Escherichia coli IAI1 histidine/lysine/arginine/ornithine ABC transporter membrane protein YP_002387776.1 2467049 R 585034 CDS YP_002387777.1 218554864 7125278 complement(2467762..2468448) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434; Product type t : transporter; histidine/lysine/arginine/ornithine ABC transporter membrane protein 2468448 hisQ 7125278 hisQ Escherichia coli IAI1 histidine/lysine/arginine/ornithine ABC transporter membrane protein YP_002387777.1 2467762 R 585034 CDS YP_002387778.1 218554865 7125280 complement(2468538..2469320) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 6449635, 8161536, 9298646, 9600841, 9740056; Product type t : transporter; histidine/lysine/arginine/ornithine ABC transporter periplasmic-binding protein 2469320 hisJ 7125280 hisJ Escherichia coli IAI1 histidine/lysine/arginine/ornithine ABC transporter periplasmic-binding protein YP_002387778.1 2468538 R 585034 CDS YP_002387779.1 218554866 7125800 complement(2470589..2471158) 1 NC_011741.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 2471158 ubiX 7125800 ubiX Escherichia coli IAI1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_002387779.1 2470589 R 585034 CDS YP_002387780.1 218554867 7125517 complement(2471253..2472770) 1 NC_011741.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 2472770 purF 7125517 purF Escherichia coli IAI1 amidophosphoribosyltransferase YP_002387780.1 2471253 R 585034 CDS YP_002387781.1 218554868 7126549 complement(2472807..2473295) 1 NC_011741.1 membrane protein required for colicin V production; colicin V production protein 2473295 cvpA 7126549 cvpA Escherichia coli IAI1 colicin V production protein YP_002387781.1 2472807 R 585034 CDS YP_002387782.1 218554869 7126867 complement(2473554..2474216) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3040734; hypothetical protein 2474216 dedD 7126867 dedD Escherichia coli IAI1 hypothetical protein YP_002387782.1 2473554 R 585034 CDS YP_002387783.1 218554870 7124558 complement(2474206..2475474) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3040739, 91112811, 92041808, 1989505, 3040734; Product type e : enzyme; bifunctional folylpolyglutamate synthase/ dihydrofolate synthase 2475474 folC 7124558 folC Escherichia coli IAI1 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase YP_002387783.1 2474206 R 585034 CDS YP_002387784.1 218554871 7127261 complement(2475544..2476458) 1 NC_011741.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 2476458 accD 7127261 accD Escherichia coli IAI1 acetyl-CoA carboxylase subunit beta YP_002387784.1 2475544 R 585034 CDS YP_002387785.1 218554872 7125693 complement(2476614..2477273) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3029016, 3040734, 7678242; Product type pm : putative membrane component; hypothetical protein 2477273 dedA 7125693 dedA Escherichia coli IAI1 hypothetical protein YP_002387785.1 2476614 R 585034 CDS YP_002387786.1 218554873 7124557 complement(2477356..2478168) 1 NC_011741.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 2478168 truA 7124557 truA Escherichia coli IAI1 tRNA pseudouridine synthase A YP_002387786.1 2477356 R 585034 CDS YP_002387787.1 218554874 7127502 complement(2478168..2479181) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 92380957, 92380982, 93123150, 2681152, 2991861, 3029016; Product type pe : putative enzyme; putative semialdehyde dehydrogenase 2479181 usg 7127502 usg Escherichia coli IAI1 putative semialdehyde dehydrogenase YP_002387787.1 2478168 R 585034 CDS YP_002387788.1 218554875 7125548 complement(2479247..2480383) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90036695, 91035267, 2681152, 2991861, 3029016; Product type e : enzyme; erythronate-4-phosphate dehydrogenase 2480383 pdxB 7125548 pdxB Escherichia coli IAI1 erythronate-4-phosphate dehydrogenase YP_002387788.1 2479247 R 585034 CDS YP_002387789.1 218554876 7124164 2480482..2481477 1 NC_011741.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 2481477 flk 7124164 flk Escherichia coli IAI1 flagella biosynthesis regulator YP_002387789.1 2480482 D 585034 CDS YP_002387790.1 218554877 7127252 complement(2481474..2482652) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 2482652 yfcJ 7127252 yfcJ Escherichia coli IAI1 hypothetical protein YP_002387790.1 2481474 R 585034 CDS YP_002387791.1 218554878 7125183 complement(2482936..2484156) 1 NC_011741.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase I 2484156 fabB 7125183 fabB Escherichia coli IAI1 3-oxoacyl-(acyl carrier protein) synthase I YP_002387791.1 2482936 R 585034 CDS YP_002387792.1 218554879 7127053 2484315..2486321 1 NC_011741.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 2486321 mnmC 7127053 mnmC Escherichia coli IAI1 5-methylaminomethyl-2-thiouridine methyltransferase YP_002387792.1 2484315 D 585034 CDS YP_002387793.1 218554880 7127489 complement(2486442..2486720) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2486720 yfcL 7127489 yfcL Escherichia coli IAI1 hypothetical protein YP_002387793.1 2486442 R 585034 CDS YP_002387794.1 218554881 7125184 complement(2486754..2487302) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2487302 yfcM 7125184 yfcM Escherichia coli IAI1 hypothetical protein YP_002387794.1 2486754 R 585034 CDS YP_002387795.1 218554882 7125185 complement(2487302..2488111) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2488111 yfcA 7125185 yfcA Escherichia coli IAI1 hypothetical protein YP_002387795.1 2487302 R 585034 CDS YP_002387796.1 218554883 7125174 complement(2488111..2488935) 1 NC_011741.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 2488935 mepA 7125174 mepA Escherichia coli IAI1 penicillin-insensitive murein endopeptidase YP_002387796.1 2488111 R 585034 CDS YP_002387797.1 218554884 7124241 complement(2488939..2490024) 1 NC_011741.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 2490024 aroC 7124241 aroC Escherichia coli IAI1 chorismate synthase YP_002387797.1 2488939 R 585034 CDS YP_002387798.1 218554885 7125804 complement(2490059..2490991) 1 NC_011741.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 2490991 prmB 7125804 prmB Escherichia coli IAI1 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_002387798.1 2490059 R 585034 CDS YP_002387799.1 218554886 7126154 2491157..2491708 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2491708 yfcN 7126154 yfcN Escherichia coli IAI1 hypothetical protein YP_002387799.1 2491157 D 585034 CDS YP_002387800.1 218554887 7125186 complement(2491903..2492883) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 2492883 7125186 ECIAI1_2409 Escherichia coli IAI1 transposase, IS110 family YP_002387800.1 2491903 R 585034 CDS YP_002387801.1 218554888 7127712 complement(2493110..2493982) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2493982 7127712 ECIAI1_2410 Escherichia coli IAI1 hypothetical protein YP_002387801.1 2493110 R 585034 CDS YP_002387802.1 218554889 7127713 complement(2493969..2494493) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial protein (Adhesin) 2494493 7127713 ECIAI1_2411 Escherichia coli IAI1 putative fimbrial protein (Adhesin) YP_002387802.1 2493969 R 585034 CDS YP_002387803.1 218554890 7127714 complement(2494490..2494960) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial protein 2494960 7127714 ECIAI1_2412 Escherichia coli IAI1 putative fimbrial protein YP_002387803.1 2494490 R 585034 CDS YP_002387804.1 218554891 7127715 complement(2494957..2495571) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative minor fimbrial subunit 2495571 7127715 ECIAI1_2413 Escherichia coli IAI1 putative minor fimbrial subunit YP_002387804.1 2494957 R 585034 CDS YP_002387805.1 218554892 7127716 complement(2495480..2496232) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative periplasmic pilus exported chaperone 2496232 yfcS 7127716 yfcS Escherichia coli IAI1 putative periplasmic pilus exported chaperone YP_002387805.1 2495480 R 585034 CDS YP_002387806.1 218554893 7125187 complement(2496252..2498894) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane usher protein yfcU 2498894 7125187 ECIAI1_2415 Escherichia coli IAI1 putative outer membrane usher protein yfcU YP_002387806.1 2496252 R 585034 CDS YP_002387807.1 218554894 7127717 complement(2498976..2499539) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein 2499539 yfcV 7127717 yfcV Escherichia coli IAI1 putative fimbrial-like adhesin exported protein YP_002387807.1 2498976 R 585034 CDS YP_002387808.1 218554895 7128702 complement(2500223..2500708) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10089421, 20200300, 9489669; Product type e : enzyme; phosphohistidine phosphatase 2500708 sixA 7128702 sixA Escherichia coli IAI1 phosphohistidine phosphatase YP_002387808.1 2500223 R 585034 CDS YP_002387809.1 218554896 7127929 complement(2500911..2503055) 1 NC_011741.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha 2503055 fadJ 7127929 fadJ Escherichia coli IAI1 multifunctional fatty acid oxidation complex subunit alpha YP_002387809.1 2500911 R 585034 CDS YP_002387810.1 218554897 7125832 complement(2503055..2504365) 1 NC_011741.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase 2504365 fadI 7125832 fadI Escherichia coli IAI1 3-ketoacyl-CoA thiolase YP_002387810.1 2503055 R 585034 CDS YP_002387811.1 218554898 7125833 complement(2504545..2504829) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2504829 yfcZ 7125833 yfcZ Escherichia coli IAI1 hypothetical protein YP_002387811.1 2504545 R 585034 CDS YP_002387812.1 218554899 7125834 2505195..2506541 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15178802, 2840553, 3286621, 91100327, 1987139, 9119048; Product type t : transporter; long-chain fatty acid outer membrane transporter 2506541 fadL 7125834 fadL Escherichia coli IAI1 long-chain fatty acid outer membrane transporter YP_002387812.1 2505195 D 585034 CDS YP_002387813.1 218554900 7127066 2506907..2507965 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2507965 yfdF 7127066 yfdF Escherichia coli IAI1 hypothetical protein YP_002387813.1 2506907 D 585034 CDS YP_002387814.1 218554901 7125837 complement(2508147..2508902) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8145644, 15352239; Product type lp : lipoprotein; hypothetical protein 2508902 vacJ 7125837 vacJ Escherichia coli IAI1 hypothetical protein YP_002387814.1 2508147 R 585034 CDS YP_002387815.1 218554902 7125566 complement(2508928..2509098) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 2509098 7125566 ECIAI1_2424 Escherichia coli IAI1 hypothetical protein YP_002387815.1 2508928 R 585034 CDS YP_002387816.1 218554903 7127718 2509196..2510128 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2510128 yfdC 7127718 yfdC Escherichia coli IAI1 hypothetical protein YP_002387816.1 2509196 D 585034 CDS YP_002387817.1 218554904 7127996 complement(2510720..2511967) 1 NC_011741.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease 2511967 lacY 7127996 lacY Escherichia coli IAI1 galactoside permease YP_002387817.1 2510720 R 585034 CDS YP_002387818.1 218554905 7125918 complement(2512039..2512953) 1 NC_011741.1 phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least; aminoimidazole riboside kinase 2512953 cscK 7125918 cscK Escherichia coli IAI1 aminoimidazole riboside kinase YP_002387818.1 2512039 R 585034 CDS YP_002387819.1 218554906 7125919 2513160..2514602 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12218016; Product type e : enzyme; Sucrose-6-phosphate hydrolase 2514602 cscA 7125919 cscA Escherichia coli IAI1 Sucrose-6-phosphate hydrolase YP_002387819.1 2513160 D 585034 CDS YP_002387820.1 218554907 7125917 complement(2514610..2515791) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Sucrose operon repressor 2515791 cscR 7125917 cscR Escherichia coli IAI1 Sucrose operon repressor YP_002387820.1 2514610 R 585034 CDS YP_002387821.1 218554908 7125027 2516072..2517400 1 NC_011741.1 catalyzes the formation of pyruvate from serine; D-serine dehydratase 2517400 dsdA 7125027 dsdA Escherichia coli IAI1 D-serine dehydratase YP_002387821.1 2516072 D 585034 CDS YP_002387822.1 218554909 7125026 complement(2517508..2519046) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20378313; Product type pt : putative transporter; putative multidrug efflux system 2519046 emrY 7125026 emrY Escherichia coli IAI1 putative multidrug efflux system YP_002387822.1 2517508 R 585034 CDS YP_002387823.1 218554910 7125064 complement(2519046..2520209) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20378313; Product type t : transporter; EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component 2520209 emrK 7125064 emrK Escherichia coli IAI1 EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component YP_002387823.1 2519046 R 585034 CDS YP_002387824.1 218554911 7125063 2520625..2521239 1 NC_011741.1 response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; DNA-binding transcriptional activator EvgA 2521239 evgA 7125063 evgA Escherichia coli IAI1 DNA-binding transcriptional activator EvgA YP_002387824.1 2520625 D 585034 CDS YP_002387825.1 218554912 7125105 2521244..2524837 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14523115, 93173621, 9501520, 10923791, 1289796, 8125343, 9535079; Product type r : regulator; hybrid sensory histidine kinase in two-component regulatory system with EvgA 2524837 evgS 7125105 evgS Escherichia coli IAI1 hybrid sensory histidine kinase in two-component regulatory system with EvgA YP_002387825.1 2521244 D 585034 CDS YP_002387826.1 218554913 7128609 complement(2524893..2526038) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2526038 yfdE 7128609 yfdE Escherichia coli IAI1 hypothetical protein YP_002387826.1 2524893 R 585034 CDS YP_002387827.1 218554914 7125836 complement(2526112..2527056) 1 NC_011741.1 member of the AEC family of auxin efflux transporters; unknown function; putative transporter YfdV 2527056 yfdV 7125836 yfdV Escherichia coli IAI1 putative transporter YfdV YP_002387827.1 2526112 R 585034 CDS YP_002387828.1 218554915 7125838 complement(2527126..2528820) 1 NC_011741.1 catalyzes the formation of formyl-CoA from oxalyl-CoA; putative oxalyl-CoA decarboxylase 2528820 oxc 7125838 oxc Escherichia coli IAI1 putative oxalyl-CoA decarboxylase YP_002387828.1 2527126 R 585034 CDS YP_002387829.1 218554916 7126001 complement(2528874..2530124) 1 NC_011741.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase 2530124 frc 7126001 frc Escherichia coli IAI1 formyl-coenzyme A transferase YP_002387829.1 2528874 R 585034 CDS YP_002387830.1 218554917 7127269 complement(2530637..2531269) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11157960; hypothetical protein 2531269 yfdX 7127269 yfdX Escherichia coli IAI1 hypothetical protein YP_002387830.1 2530637 R 585034 CDS YP_002387831.1 218554918 7125839 2531603..2531878 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15183873; Product type lp : lipoprotein; hypothetical protein 2531878 ypdI 7125839 ypdI Escherichia coli IAI1 hypothetical protein YP_002387831.1 2531603 D 585034 CDS YP_002387832.1 218554919 7124317 complement(2531955..2532197) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089; Product type pm : putative membrane component; hypothetical protein 2532197 yfdY 7124317 yfdY Escherichia coli IAI1 hypothetical protein YP_002387832.1 2531955 R 585034 CDS YP_002387834.1 218554921 7127719 2532550..2533470 1 NC_011741.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 2533470 ddg 7127719 ddg Escherichia coli IAI1 lipid A biosynthesis palmitoleoyl acyltransferase YP_002387834.1 2532550 D 585034 CDS YP_002387835.1 218554922 7127477 complement(2533962..2535200) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; aminotransferase 2535200 yfdZ 7127477 yfdZ Escherichia coli IAI1 aminotransferase YP_002387835.1 2533962 R 585034 CDS YP_002387836.1 218554923 7125841 2535577..2537274 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15522865; Product type prc : putative receptor; putative sensory kinase in two-component system with YpdB 2537274 ypdA 7125841 ypdA Escherichia coli IAI1 putative sensory kinase in two-component system with YpdB YP_002387836.1 2535577 D 585034 CDS YP_002387837.1 218554924 7124309 2537289..2538023 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15522865; Product type pr : putative regulator; putative response regulator in two-component system with YpdA 2538023 ypdB 7124309 ypdB Escherichia coli IAI1 putative response regulator in two-component system with YpdA YP_002387837.1 2537289 D 585034 CDS YP_002387838.1 218554925 7124310 2538036..2538893 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding protein 2538893 ypdC 7124310 ypdC Escherichia coli IAI1 putative DNA-binding protein YP_002387838.1 2538036 D 585034 CDS YP_002387839.1 218554926 7124311 complement(2538896..2541391) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative fused PTS enzymes (multiphosphoryl transfer protein): Hpr component ; enzyme I component ; enzyme IIA component 2541391 ypdD 7124311 ypdD Escherichia coli IAI1 putative fused PTS enzymes (multiphosphoryl transfer protein): Hpr component ; enzyme I component ; enzyme IIA component YP_002387839.1 2538896 R 585034 CDS YP_002387840.1 218554927 7124312 complement(2541416..2542453) 1 NC_011741.1 metalloprotein; exoaminopeptidase 2542453 ypdE 7124312 ypdE Escherichia coli IAI1 exoaminopeptidase YP_002387840.1 2541416 R 585034 CDS YP_002387841.1 218554928 7124313 complement(2542453..2543538) 1 NC_011741.1 Xaa-Pro aminopeptidase; limited methionine aminopeptidase; aminopeptidase 2543538 ypdF 7124313 ypdF Escherichia coli IAI1 aminopeptidase YP_002387841.1 2542453 R 585034 CDS YP_002387842.1 218554929 7124314 complement(2543553..2544800) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative PTS system transporter subunit IIC 2544800 ypdG 7124314 ypdG Escherichia coli IAI1 putative PTS system transporter subunit IIC YP_002387842.1 2543553 R 585034 CDS YP_002387843.1 218554930 7124315 complement(2544822..2545148) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative PTS system transporter subunit IIB 2545148 ypdH 7124315 ypdH Escherichia coli IAI1 putative PTS system transporter subunit IIB YP_002387843.1 2544822 R 585034 CDS YP_002387844.1 218554931 7124316 complement(2545368..2546333) 1 NC_011741.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase 2546333 glk 7124316 glk Escherichia coli IAI1 glucokinase YP_002387844.1 2545368 R 585034 CDS YP_002387845.1 218554932 7128317 2546537..2547793 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 2547793 yfeO 7128317 yfeO Escherichia coli IAI1 hypothetical protein YP_002387845.1 2546537 D 585034 CDS YP_002387846.1 218554933 7125848 2547908..2548234 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2548234 ypeC 7125848 ypeC Escherichia coli IAI1 hypothetical protein YP_002387846.1 2547908 D 585034 CDS YP_002387847.1 218554934 7124319 complement(2548375..2549613) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20177822, 20305051, 10712688, 10844693; Product type t : transporter; manganese transport protein MntH 2549613 mntH 7124319 mntH Escherichia coli IAI1 manganese transport protein MntH YP_002387847.1 2548375 R 585034 CDS YP_002387848.1 218554935 7124288 2549949..2551151 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 374403, 8022285, 7007808, 827549, 4563236, 1512211; Product type t : transporter; nucleoside (except guanosine) transporter 2551151 nupC 7124288 nupC Escherichia coli IAI1 nucleoside (except guanosine) transporter YP_002387848.1 2549949 D 585034 CDS YP_002387849.1 218554936 7125971 complement(2551201..2553390) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase 2553390 yfeA 7125971 yfeA Escherichia coli IAI1 putative diguanylate cyclase YP_002387849.1 2551201 R 585034 CDS YP_002387850.1 218554937 7128047 2554025..2554369 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative nucleic acid-binding transcriptional regulator 2554369 yfeC 7128047 yfeC Escherichia coli IAI1 putative nucleic acid-binding transcriptional regulator YP_002387850.1 2554025 D 585034 CDS YP_002387851.1 218554938 7125843 2554371..2554763 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative nucleic acid-binding transcriptional regulator 2554763 yfeD 7125843 yfeD Escherichia coli IAI1 putative nucleic acid-binding transcriptional regulator YP_002387851.1 2554371 D 585034 CDS YP_002387852.1 218554939 7125844 complement(2554815..2556230) 1 NC_011741.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 2556230 gltX 7125844 gltX Escherichia coli IAI1 glutamyl-tRNA synthetase YP_002387852.1 2554815 R 585034 CDS YP_002387853.1 218554940 7128000 2557162..2557503 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2557503 7128000 ECIAI1_2465 Escherichia coli IAI1 hypothetical protein YP_002387853.1 2557162 D 585034 CDS YP_002387854.1 218554941 7127720 complement(2557494..2558420) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2558420 yfeR 7127720 yfeR Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002387854.1 2557494 R 585034 CDS YP_002387855.1 218554942 7125849 2558510..2559508 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative sodium/bile acid symporter familyprotein 2559508 yfeH 7125849 yfeH Escherichia coli IAI1 putative sodium/bile acid symporter familyprotein YP_002387855.1 2558510 D 585034 CDS YP_002387856.1 218554943 7125846 complement(2559505..2559822) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 2559822 7125846 ECIAI1_2468 Escherichia coli IAI1 hypothetical protein YP_002387856.1 2559505 R 585034 CDS YP_002387857.1 218554944 7127721 complement(2559725..2561740) 1 NC_011741.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 2561740 ligA 7127721 ligA Escherichia coli IAI1 NAD-dependent DNA ligase LigA YP_002387857.1 2559725 R 585034 CDS YP_002387858.1 218554945 7126418 complement(2561811..2562797) 1 NC_011741.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA 2562797 zipA 7126418 zipA Escherichia coli IAI1 cell division protein ZipA YP_002387858.1 2561811 R 585034 CDS YP_002387859.1 218554946 7128124 2563027..2563788 1 NC_011741.1 putative role in sulfur assimilation; putative sulfate transport protein CysZ 2563788 cysZ 7128124 cysZ Escherichia coli IAI1 putative sulfate transport protein CysZ YP_002387859.1 2563027 D 585034 CDS YP_002387860.1 218554947 7126904 2563973..2564944 1 NC_011741.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 2564944 cysK 7126904 cysK Escherichia coli IAI1 cysteine synthase A YP_002387860.1 2563973 D 585034 CDS YP_002387861.1 218554948 7126896 2565328..2565585 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type t : transporter; PTS system phosphohistidinoprotein-hexose phosphotransferase subunit Hpr 2565585 ptsH 7126896 ptsH Escherichia coli IAI1 PTS system phosphohistidinoprotein-hexose phosphotransferase subunit Hpr YP_002387861.1 2565328 D 585034 CDS YP_002387862.1 218554949 7126540 2565630..2567357 1 NC_011741.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 2567357 ptsI 7126540 ptsI Escherichia coli IAI1 phosphoenolpyruvate-protein phosphotransferase YP_002387862.1 2565630 D 585034 CDS YP_002387863.1 218554950 7126541 2567398..2567907 1 NC_011741.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter subunit 2567907 crr 7126541 crr Escherichia coli IAI1 PTS system glucose-specific transporter subunit YP_002387863.1 2567398 D 585034 CDS YP_002387864.1 218554951 7125916 complement(2567949..2568800) 1 NC_011741.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase 2568800 pdxK 7125916 pdxK Escherichia coli IAI1 pyridoxal kinase YP_002387864.1 2567949 R 585034 CDS YP_002387865.1 218554952 7124167 2568905..2569273 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2569273 yfeK 7124167 yfeK Escherichia coli IAI1 hypothetical protein YP_002387865.1 2568905 D 585034 CDS YP_002387866.1 218554953 7125847 complement(2569276..2570187) 1 NC_011741.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B 2570187 cysM 7125847 cysM Escherichia coli IAI1 cysteine synthase B YP_002387866.1 2569276 R 585034 CDS YP_002387867.1 218554954 7126897 complement(2570321..2571418) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202710, 90264334, 2188958, 7665461; Product type t : transporter; sulfate/thiosulfate transporter subunit 2571418 cysA 7126897 cysA Escherichia coli IAI1 sulfate/thiosulfate transporter subunit YP_002387867.1 2570321 R 585034 CDS YP_002387868.1 218554955 7126887 complement(2571408..2572283) 1 NC_011741.1 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate transporter permease subunit 2572283 cysW 7126887 cysW Escherichia coli IAI1 sulfate/thiosulfate transporter permease subunit YP_002387868.1 2571408 R 585034 CDS YP_002387869.1 218554956 7126903 complement(2572283..2573116) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264334, 2188958; Product type t : transporter; sulfate/thiosulfate transporter subunit 2573116 cysU 7126903 cysU Escherichia coli IAI1 sulfate/thiosulfate transporter subunit YP_002387869.1 2572283 R 585034 CDS YP_002387870.1 218554957 7126902 complement(2573116..2574132) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264335, 2188959, 9298646; Product type t : transporter; thiosulfate transporter subunit 2574132 cysP 7126902 cysP Escherichia coli IAI1 thiosulfate transporter subunit YP_002387870.1 2573116 R 585034 CDS YP_002387871.1 218554958 7126899 complement(2574290..2575081) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 97385354, 2188959, 7984428, 9241368; Product type pe : putative enzyme; short chain dehydrogenase 2575081 ucpA 7126899 ucpA Escherichia coli IAI1 short chain dehydrogenase YP_002387871.1 2574290 R 585034 CDS YP_002387872.1 218554959 7125518 complement(2575210..2576067) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2576067 yfeT 7125518 yfeT Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002387872.1 2575210 R 585034 CDS YP_002387873.1 218554960 7125850 2576231..2577127 1 NC_011741.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid-6-phosphate etherase 2577127 murQ 7125850 murQ Escherichia coli IAI1 N-acetylmuramic acid-6-phosphate etherase YP_002387873.1 2576231 D 585034 CDS YP_002387874.1 218554961 7125851 2577131..2578555 1 NC_011741.1 belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; PTS system N-acetylmuramic acid transporter subunits EIIBC 2578555 murP 7125851 murP Escherichia coli IAI1 PTS system N-acetylmuramic acid transporter subunits EIIBC YP_002387874.1 2577131 D 585034 CDS YP_002387875.1 218554962 7124500 2578560..2579864 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15983044, 15060041; Product type e : enzyme; hypothetical protein 2579864 murQ 7124500 murQ Escherichia coli IAI1 hypothetical protein YP_002387875.1 2578560 D 585034 CDS YP_002387876.1 218554963 7124501 complement(2579922..2580821) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2580821 yfeX 7124501 yfeX Escherichia coli IAI1 hypothetical protein YP_002387876.1 2579922 R 585034 CDS YP_002387877.1 218554964 7125852 complement(2580917..2581492) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12900013, 7764507; hypothetical protein 2581492 yfeY 7125852 yfeY Escherichia coli IAI1 hypothetical protein YP_002387877.1 2580917 R 585034 CDS YP_002387878.1 218554965 7125853 complement(2581553..2582002) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2582002 yfeZ 7125853 yfeZ Escherichia coli IAI1 hypothetical protein YP_002387878.1 2581553 R 585034 CDS YP_002387879.1 218554966 7125854 complement(2581989..2582414) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase 2582414 ypeA 7125854 ypeA Escherichia coli IAI1 putative acetyltransferase YP_002387879.1 2581989 R 585034 CDS YP_002387880.1 218554967 7124318 2582628..2583497 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21348478, 6137479, 87242501, 1903834, 8300522; Product type e : enzyme; N-acetylmuramoyl-l-alanine amidase I 2583497 amiA 7124318 amiA Escherichia coli IAI1 N-acetylmuramoyl-l-alanine amidase I YP_002387880.1 2582628 D 585034 CDS YP_002387881.1 218554968 7125752 2583501..2584400 1 NC_011741.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 2584400 hemF 7125752 hemF Escherichia coli IAI1 coproporphyrinogen III oxidase YP_002387881.1 2583501 D 585034 CDS YP_002387882.1 218554969 7128510 complement(2584406..2585458) 1 NC_011741.1 activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR 2585458 yfeG 7128510 yfeG Escherichia coli IAI1 transcriptional regulator EutR YP_002387882.1 2584406 R 585034 CDS YP_002387883.1 218554970 7125845 complement(2585504..2586004) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10464203; Product type ps : putative structure; putative ethanolaminosome structural protein 2586004 yffI 7125845 yffI Escherichia coli IAI1 putative ethanolaminosome structural protein YP_002387883.1 2585504 R 585034 CDS YP_002387884.1 218554971 7125857 complement(2586017..2586676) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein 2586676 eutL 7125857 eutL Escherichia coli IAI1 putative carboxysome-like ethanolaminosome structural protein YP_002387884.1 2586017 R 585034 CDS YP_002387885.1 218554972 7125101 complement(2586686..2587573) 1 NC_011741.1 catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit 2587573 eutC 7125101 eutC Escherichia coli IAI1 ethanolamine ammonia-lyase small subunit YP_002387885.1 2586686 R 585034 CDS YP_002387886.1 218554973 7125095 complement(2587594..2588955) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3905806, 10464203; Product type e : enzyme; ethanolamine ammonia-lyase, large subunit, heavy chain 2588955 eutB 7125095 eutB Escherichia coli IAI1 ethanolamine ammonia-lyase, large subunit, heavy chain YP_002387886.1 2587594 R 585034 CDS YP_002387887.1 218554974 7125094 complement(2588967..2590370) 1 NC_011741.1 ethanolamine utilization protein EutA; reactivating factor for ethanolamine ammonia lyase 2590370 eutA 7125094 eutA Escherichia coli IAI1 reactivating factor for ethanolamine ammonia lyase YP_002387887.1 2588967 R 585034 CDS YP_002387888.1 218554975 7125093 complement(2590367..2591593) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7868611, 10464203; Product type pt : putative transporter; putative ethanolamine transporter 2591593 eutH 7125093 eutH Escherichia coli IAI1 putative ethanolamine transporter YP_002387888.1 2590367 R 585034 CDS YP_002387889.1 218554976 7125098 complement(2591710..2592897) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative alcohol dehydrogenase 2592897 eutG 7125098 eutG Escherichia coli IAI1 putative alcohol dehydrogenase YP_002387889.1 2591710 R 585034 CDS YP_002387890.1 218554977 7125097 complement(2592887..2593723) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pf : putative factor; putative chaperonin 2593723 eutJ 7125097 eutJ Escherichia coli IAI1 putative chaperonin YP_002387890.1 2592887 R 585034 CDS YP_002387891.1 218554978 7125100 complement(2593734..2595137) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative aldehyde dehydrogenase 2595137 eutE 7125100 eutE Escherichia coli IAI1 putative aldehyde dehydrogenase YP_002387891.1 2593734 R 585034 CDS YP_002387892.1 218554979 7125096 complement(2595149..2595436) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein 2595436 cchB 7125096 cchB Escherichia coli IAI1 putative carboxysome-like ethanolaminosome structural protein YP_002387892.1 2595149 R 585034 CDS YP_002387893.1 218554980 7124457 complement(2595543..2595836) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein 2595836 cchA 7124457 cchA Escherichia coli IAI1 putative carboxysome-like ethanolaminosome structural protein YP_002387893.1 2595543 R 585034 CDS YP_002387894.1 218554981 7124456 complement(2595875..2596891) 1 NC_011741.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 2596891 eutD 7124456 eutD Escherichia coli IAI1 phosphotransacetylase YP_002387894.1 2595875 R 585034 CDS YP_002387895.1 218554982 7125099 complement(2596888..2597691) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative cobalamin adenosyltransferase in ethanolamine utilization 2597691 eutT 7125099 eutT Escherichia coli IAI1 putative cobalamin adenosyltransferase in ethanolamine utilization YP_002387895.1 2596888 R 585034 CDS YP_002387896.1 218554983 7125104 complement(2597688..2598389) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10464203; hypothetical protein 2598389 eutQ 7125104 eutQ Escherichia coli IAI1 hypothetical protein YP_002387896.1 2597688 R 585034 CDS YP_002387897.1 218554984 7125103 complement(2598364..2598843) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative nucleoside triphosphate hydrolase domain-containing protein 2598843 eutP 7125103 eutP Escherichia coli IAI1 putative nucleoside triphosphate hydrolase domain-containing protein YP_002387897.1 2598364 R 585034 CDS YP_002387898.1 218554985 7125102 complement(2598856..2599191) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein 2599191 ypfE 7125102 ypfE Escherichia coli IAI1 putative carboxysome-like ethanolaminosome structural protein YP_002387898.1 2598856 R 585034 CDS YP_002387899.1 218554986 7124320 complement(2599484..2601763) 1 NC_011741.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 2601763 maeB 7124320 maeB Escherichia coli IAI1 malic enzyme YP_002387899.1 2599484 R 585034 CDS YP_002387900.1 218554987 7127652 2602052..2603002 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90230300; Product type e : enzyme; transaldolase A 2603002 talA 7127652 talA Escherichia coli IAI1 transaldolase A YP_002387900.1 2602052 D 585034 CDS YP_002387901.1 218554988 7126208 2603022..2605025 1 NC_011741.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2605025 tktB 7126208 tktB Escherichia coli IAI1 transketolase YP_002387901.1 2603022 D 585034 CDS YP_002387902.1 218554989 7127452 complement(2605121..2606164) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2606164 ypfG 7127452 ypfG Escherichia coli IAI1 hypothetical protein YP_002387902.1 2605121 R 585034 CDS YP_002387903.1 218554990 7124321 complement(2606290..2606865) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NUDIX hydrolase 2606865 yffH 7124321 yffH Escherichia coli IAI1 putative NUDIX hydrolase YP_002387903.1 2606290 R 585034 CDS YP_002387904.1 218554991 7125856 complement(2606933..2608912) 1 NC_011741.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); putative oxidoreductase Fe-S binding subunit 2608912 aegA 7125856 aegA Escherichia coli IAI1 putative oxidoreductase Fe-S binding subunit YP_002387904.1 2606933 R 585034 CDS YP_002387905.1 218554992 7125724 2609118..2610818 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92374842, 1508040, 1528845; Product type r : regulator; nitrate/nitrite sensor protein NarQ 2610818 narQ 7125724 narQ Escherichia coli IAI1 nitrate/nitrite sensor protein NarQ YP_002387905.1 2609118 D 585034 CDS YP_002387906.1 218554993 7128608 2610982..2614095 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12426336, 20158894, 21450803, 79216220, 10692383, 1644752; Product type t : transporter; aminoglycoside/multidrug efflux system 2614095 acrD 7128608 acrD Escherichia coli IAI1 aminoglycoside/multidrug efflux system YP_002387906.1 2610982 D 585034 CDS YP_002387907.1 218554994 7125708 2614634..2614990 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2614990 yffB 7125708 yffB Escherichia coli IAI1 hypothetical protein YP_002387907.1 2614634 D 585034 CDS YP_002387908.1 218554995 7125855 2614994..2616121 1 NC_011741.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2616121 dapE 7125855 dapE Escherichia coli IAI1 succinyl-diaminopimelate desuccinylase YP_002387908.1 2614994 D 585034 CDS YP_002387909.1 218554996 7126919 2616149..2616349 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2616349 ypfN 7126919 ypfN Escherichia coli IAI1 hypothetical protein YP_002387909.1 2616149 D 585034 CDS YP_002387910.1 218554997 7124325 complement(2616459..2617157) 1 NC_011741.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YpfH 2617157 ypfH 7124325 ypfH Escherichia coli IAI1 esterase YpfH YP_002387910.1 2616459 R 585034 CDS YP_002387911.1 218554998 7124322 complement(2617231..2619246) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 2619246 ypfI 7124322 ypfI Escherichia coli IAI1 putative hydrolase YP_002387911.1 2617231 R 585034 CDS YP_002387912.1 218554999 7124323 complement(2619261..2620124) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2620124 ypfJ 7124323 ypfJ Escherichia coli IAI1 hypothetical protein YP_002387912.1 2619261 R 585034 CDS YP_002387913.1 218555000 7124324 complement(2620271..2620669) 1 NC_011741.1 stability determinant protein; plasmid maintenance protein 2620669 7124324 ECIAI1_2525 Escherichia coli IAI1 plasmid maintenance protein YP_002387913.1 2620271 R 585034 CDS YP_002387914.1 218555001 7127722 complement(2620669..2620935) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2620935 7127722 ECIAI1_2526 Escherichia coli IAI1 hypothetical protein YP_002387914.1 2620669 R 585034 CDS YP_002387915.1 218555002 7127723 complement(2621051..2621764) 1 NC_011741.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 2621764 purC 7127723 purC Escherichia coli IAI1 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_002387915.1 2621051 R 585034 CDS YP_002387916.1 218555003 7126546 complement(2621977..2623011) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358331, 1885529, 2120198; Product type lp : lipoprotein; lipoprotein 2623011 nlpB 7126546 nlpB Escherichia coli IAI1 lipoprotein YP_002387916.1 2621977 R 585034 CDS YP_002387917.1 218555004 7127888 complement(2623028..2623906) 1 NC_011741.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 2623906 dapA 7127888 dapA Escherichia coli IAI1 dihydrodipicolinate synthase YP_002387917.1 2623028 R 585034 CDS YP_002387918.1 218555005 7126916 2624052..2624624 1 NC_011741.1 negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 2624624 gcvR 7126916 gcvR Escherichia coli IAI1 glycine cleavage system transcriptional repressor YP_002387918.1 2624052 D 585034 CDS YP_002387919.1 218555006 7128298 2624624..2625094 1 NC_011741.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 2625094 bcp 7128298 bcp Escherichia coli IAI1 thioredoxin-dependent thiol peroxidase YP_002387919.1 2624624 D 585034 CDS YP_002387920.1 218555007 7124384 2625347..2625964 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241, 2016588; Product type c : carrier; hydrogenase 4, 4Fe-4S subunit 2625964 hyfA 7124384 hyfA Escherichia coli IAI1 hydrogenase 4, 4Fe-4S subunit YP_002387920.1 2625347 D 585034 CDS YP_002387921.1 218555008 7126017 2625964..2627982 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4 subunit B 2627982 hyfB 7126017 hyfB Escherichia coli IAI1 hydrogenase 4 subunit B YP_002387921.1 2625964 D 585034 CDS YP_002387922.1 218555009 7126018 2627972..2628940 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4, membrane subunit 2628940 hyfC 7126018 hyfC Escherichia coli IAI1 hydrogenase 4, membrane subunit YP_002387922.1 2627972 D 585034 CDS YP_002387923.1 218555010 7126019 2629043..2630395 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4 subunit D 2630395 hyfD 7126019 hyfD Escherichia coli IAI1 hydrogenase 4 subunit D YP_002387923.1 2629043 D 585034 CDS YP_002387924.1 218555011 7126020 2630407..2631057 1 NC_011741.1 interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 2631057 hyfE 7126020 hyfE Escherichia coli IAI1 hydrogenase 4 membrane subunit YP_002387924.1 2630407 D 585034 CDS YP_002387925.1 218555012 7126021 2631062..2632642 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4 subunit F 2632642 hyfF 7126021 hyfF Escherichia coli IAI1 hydrogenase 4 subunit F YP_002387925.1 2631062 D 585034 CDS YP_002387926.1 218555013 7126022 2632680..2634347 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type c : carrier; hydrogenase 4 subunit 2634347 hyfG 7126022 hyfG Escherichia coli IAI1 hydrogenase 4 subunit YP_002387926.1 2632680 D 585034 CDS YP_002387927.1 218555014 7126023 2634357..2634896 1 NC_011741.1 probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far; hydrogenase 4 subunit H 2634896 hyfH 7126023 hyfH Escherichia coli IAI1 hydrogenase 4 subunit H YP_002387927.1 2634357 D 585034 CDS YP_002387928.1 218555015 7126024 2634893..2635651 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type c : carrier; hydrogenase 4, Fe-S subunit 2635651 hyfI 7126024 hyfI Escherichia coli IAI1 hydrogenase 4, Fe-S subunit YP_002387928.1 2634893 D 585034 CDS YP_002387929.1 218555016 7126025 2635644..2636057 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9387241; Product type pf : putative factor; putative processing element hydrogenase 4 2636057 hyfJ 7126025 hyfJ Escherichia coli IAI1 putative processing element hydrogenase 4 YP_002387929.1 2635644 D 585034 CDS YP_002387930.1 218555017 7126026 2636087..2638099 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type r : regulator; DNA-binding transcriptional activator, formate sensing 2638099 hyfR 7126026 hyfR Escherichia coli IAI1 DNA-binding transcriptional activator, formate sensing YP_002387930.1 2636087 D 585034 CDS YP_002387931.1 218555018 7127258 complement(2639006..2640067) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease 2640067 perM 7127258 perM Escherichia coli IAI1 putative permease YP_002387931.1 2639006 R 585034 CDS YP_002387932.1 218555019 7124177 2640280..2641743 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 2641743 yfgC 7124177 yfgC Escherichia coli IAI1 putative peptidase YP_002387932.1 2640280 D 585034 CDS YP_002387933.1 218555020 7125860 2641764..2642123 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 2642123 yfgD 7125860 yfgD Escherichia coli IAI1 putative oxidoreductase YP_002387933.1 2641764 D 585034 CDS YP_002387934.1 218555021 7125861 complement(2642261..2643007) 1 NC_011741.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor 2643007 hda 7125861 hda Escherichia coli IAI1 DNA replication initiation factor YP_002387934.1 2642261 R 585034 CDS YP_002387935.1 218555022 7128498 complement(2643057..2644346) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8332529, 7721693; Product type t : transporter; uracil transporter 2644346 uraA 7128498 uraA Escherichia coli IAI1 uracil transporter YP_002387935.1 2643057 R 585034 CDS YP_002387936.1 218555023 7125547 complement(2644432..2645058) 1 NC_011741.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 2645058 upp 7125547 upp Escherichia coli IAI1 uracil phosphoribosyltransferase YP_002387936.1 2644432 R 585034 CDS YP_002387937.1 218555024 7125546 2645383..2646420 1 NC_011741.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2646420 purM 7125546 purM Escherichia coli IAI1 phosphoribosylaminoimidazole synthetase YP_002387937.1 2645383 D 585034 CDS YP_002387938.1 218555025 7126553 2646420..2647058 1 NC_011741.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 2647058 purN 7126553 purN Escherichia coli IAI1 phosphoribosylglycinamide formyltransferase YP_002387938.1 2646420 D 585034 CDS YP_002387939.1 218555026 7126554 2647229..2649295 1 NC_011741.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2649295 ppk 7126554 ppk Escherichia coli IAI1 polyphosphate kinase YP_002387939.1 2647229 D 585034 CDS YP_002387940.1 218555027 7126136 2649300..2650841 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93107072, 94025037, 94165003, 8212131, 8380170; Product type e : enzyme; exopolyphosphatase 2650841 ppx 7126136 ppx Escherichia coli IAI1 exopolyphosphatase YP_002387940.1 2649300 D 585034 CDS YP_002387941.1 218555028 7126139 complement(2650880..2653123) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2653123 yfgF 7126139 yfgF Escherichia coli IAI1 hypothetical protein YP_002387941.1 2650880 R 585034 CDS YP_002387942.1 218555029 7125862 complement(2653340..2653630) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 2653630 7125862 ECIAI1_2556 Escherichia coli IAI1 hypothetical protein YP_002387942.1 2653340 R 585034 CDS YP_002387943.1 218555030 7127724 2653977..2654495 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein 2654495 yfgH 7127724 yfgH Escherichia coli IAI1 putative outer membrane lipoprotein YP_002387943.1 2653977 D 585034 CDS YP_002387944.1 218555031 7125863 2654511..2655050 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2655050 yfgI 7125863 yfgI Escherichia coli IAI1 hypothetical protein YP_002387944.1 2654511 D 585034 CDS YP_002387945.1 218555032 7125864 complement(2655145..2656722) 1 NC_011741.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 2656722 guaA 7125864 guaA Escherichia coli IAI1 GMP synthase YP_002387945.1 2655145 R 585034 CDS YP_002387946.1 218555033 7128476 complement(2656791..2658257) 1 NC_011741.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 2658257 guaB 7128476 guaB Escherichia coli IAI1 inosine 5'-monophosphate dehydrogenase YP_002387946.1 2656791 R 585034 CDS YP_002387947.1 218555034 7128477 2658419..2659789 1 NC_011741.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2659789 xseA 7128477 xseA Escherichia coli IAI1 exodeoxyribonuclease VII large subunit YP_002387947.1 2658419 D 585034 CDS YP_002387948.1 218555035 7126474 complement(2659786..2660001) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2660001 yfgJ 7126474 yfgJ Escherichia coli IAI1 hypothetical protein YP_002387948.1 2659786 R 585034 CDS YP_002387949.1 218555036 7125865 complement(2660070..2661542) 1 NC_011741.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 2661542 engA 7125865 engA Escherichia coli IAI1 GTP-binding protein EngA YP_002387949.1 2660070 R 585034 CDS YP_002387950.1 218555037 7124569 complement(2661660..2662838) 1 NC_011741.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL 2662838 yfgL 7124569 yfgL Escherichia coli IAI1 outer membrane protein assembly complex subunit YfgL YP_002387950.1 2661660 R 585034 CDS YP_002387951.1 218555038 7125866 complement(2662849..2663469) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2663469 yfgM 7125866 yfgM Escherichia coli IAI1 hypothetical protein YP_002387951.1 2662849 R 585034 CDS YP_002387952.1 218555039 7125867 complement(2663487..2664761) 1 NC_011741.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 2664761 hisS 7125867 hisS Escherichia coli IAI1 histidyl-tRNA synthetase YP_002387952.1 2663487 R 585034 CDS YP_002387953.1 218555040 7125496 complement(2664872..2665990) 1 NC_011741.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2665990 ispG 7125496 ispG Escherichia coli IAI1 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_002387953.1 2664872 R 585034 CDS YP_002387954.1 218555041 7126084 complement(2666017..2667030) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; cytoskeletal protein RodZ 2667030 yfgA 7126084 yfgA Escherichia coli IAI1 cytoskeletal protein RodZ YP_002387954.1 2666017 R 585034 CDS YP_002387955.1 218555042 7125858 complement(2667315..2668469) 1 NC_011741.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 2668469 yfgB 7125858 yfgB Escherichia coli IAI1 ribosomal RNA large subunit methyltransferase N YP_002387955.1 2667315 R 585034 CDS YP_002387956.1 218555043 7125859 complement(2668619..2669050) 1 NC_011741.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 2669050 ndk 7125859 ndk Escherichia coli IAI1 nucleoside diphosphate kinase YP_002387956.1 2668619 R 585034 CDS YP_002387957.1 218555044 7127864 complement(2669199..2671511) 1 NC_011741.1 penicillin-insensitive transglycosylase/transpeptidase; penicillin-binding protein 1C 2671511 pbpC 7127864 pbpC Escherichia coli IAI1 penicillin-binding protein 1C YP_002387957.1 2669199 R 585034 CDS YP_002387958.1 218555045 7124157 complement(2671512..2676473) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2676473 yfhM 7124157 yfhM Escherichia coli IAI1 hypothetical protein YP_002387958.1 2671512 R 585034 CDS YP_002387959.1 218555046 7125876 2676680..2677525 1 NC_011741.1 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 2677525 sseA 7125876 sseA Escherichia coli IAI1 3-mercaptopyruvate sulfurtransferase YP_002387959.1 2676680 D 585034 CDS YP_002387960.1 218555047 7124657 complement(2678018..2678794) 1 NC_011741.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB 2678794 sseB 7124657 sseB Escherichia coli IAI1 enhanced serine sensitivity protein SseB YP_002387960.1 2678018 R 585034 CDS YP_002387961.1 218555048 7127981 complement(2678936..2680219) 1 NC_011741.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase B 2680219 pepB 7127981 pepB Escherichia coli IAI1 aminopeptidase B YP_002387961.1 2678936 R 585034 CDS YP_002387962.1 218555049 7124170 complement(2680397..2680597) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10393315; Product type pf : putative factor; hypothetical protein 2680597 yfhJ 7124170 yfhJ Escherichia coli IAI1 hypothetical protein YP_002387962.1 2680397 R 585034 CDS YP_002387963.1 218555050 7125873 complement(2680609..2680944) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10393315, 20013001, 92283811, 94181532, 11551196, 1317854, 4375562, 8300516; Product type c : carrier; [2Fe-2S] ferredoxin 2680944 fdx 7125873 fdx Escherichia coli IAI1 [2Fe-2S] ferredoxin YP_002387963.1 2680609 R 585034 CDS YP_002387964.1 218555051 7127082 complement(2680946..2682796) 1 NC_011741.1 involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 2682796 hscA 7127082 hscA Escherichia coli IAI1 chaperone protein HscA YP_002387964.1 2680946 R 585034 CDS YP_002387965.1 218555052 7125309 complement(2682813..2683328) 1 NC_011741.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB 2683328 hscB 7125309 hscB Escherichia coli IAI1 co-chaperone HscB YP_002387965.1 2682813 R 585034 CDS YP_002387966.1 218555053 7125310 complement(2683424..2683747) 1 NC_011741.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein 2683747 iscA 7125310 iscA Escherichia coli IAI1 iron-sulfur cluster assembly protein YP_002387966.1 2683424 R 585034 CDS YP_002387967.1 218555054 7126074 complement(2683764..2684150) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10393315, 11994302, 15153099; Product type f : factor; scaffold protein 2684150 iscU 7126074 iscU Escherichia coli IAI1 scaffold protein YP_002387967.1 2683764 R 585034 CDS YP_002387968.1 218555055 7126077 complement(2684178..2685392) 1 NC_011741.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 2685392 iscS 7126077 iscS Escherichia coli IAI1 cysteine desulfurase YP_002387968.1 2684178 R 585034 CDS YP_002387969.1 218555056 7126076 complement(2685504..2685992) 1 NC_011741.1 regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR 2685992 iscR 7126076 iscR Escherichia coli IAI1 DNA-binding transcriptional regulator IscR YP_002387969.1 2685504 R 585034 CDS YP_002387970.1 218555057 7126075 complement(2686293..2687030) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10393315; Product type pe : putative enzyme; putative methyltransferase 2687030 yfhQ 7126075 yfhQ Escherichia coli IAI1 putative methyltransferase YP_002387970.1 2686293 R 585034 CDS YP_002387971.1 218555058 7125877 2687149..2687952 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6389495, 90202735, 95095968, 10747806, 2138605, 8002619; Product type e : enzyme; inositol monophosphatase 2687952 suhB 7125877 suhB Escherichia coli IAI1 inositol monophosphatase YP_002387971.1 2687149 D 585034 CDS YP_002387972.1 218555059 7126200 2688070..2688951 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 2688951 yfhR 7126200 yfhR Escherichia coli IAI1 putative peptidase YP_002387972.1 2688070 D 585034 CDS YP_002387973.1 218555060 7125878 2689142..2690422 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95020540, 96154950; Product type cp : cell process; stationary phase inducible protein CsiE 2690422 csiE 7125878 csiE Escherichia coli IAI1 stationary phase inducible protein CsiE YP_002387973.1 2689142 D 585034 CDS YP_002387974.1 218555061 7125929 complement(2690414..2691553) 1 NC_011741.1 putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; putative 3-phenylpropionic acid transporter 2691553 hcaT 7125929 hcaT Escherichia coli IAI1 putative 3-phenylpropionic acid transporter YP_002387974.1 2690414 R 585034 CDS YP_002387975.1 218555062 7128494 complement(2691713..2692603) 1 NC_011741.1 activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional regulator HcaR 2692603 hcaR 7128494 hcaR Escherichia coli IAI1 DNA-binding transcriptional regulator HcaR YP_002387975.1 2691713 R 585034 CDS YP_002387976.1 218555063 7128493 2692739..2694100 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83238171, 87008429, 98269008; Product type e : enzyme; 3-phenylpropionate dioxygenase, large alpha subunit 2694100 hcaE 7128493 hcaE Escherichia coli IAI1 3-phenylpropionate dioxygenase, large alpha subunit YP_002387976.1 2692739 D 585034 CDS YP_002387977.1 218555064 7128491 2694097..2694615 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83238171, 87008429, 98269008, 9603882; Product type e : enzyme; 3-phenylpropionate dioxygenase subunit beta 2694615 hcaF 7128491 hcaF Escherichia coli IAI1 3-phenylpropionate dioxygenase subunit beta YP_002387977.1 2694097 D 585034 CDS YP_002387978.1 218555065 7128492 2694615..2694935 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98269008, 9603882; Product type pc : putative carrier; 3-phenylpropionate dioxygenase ferredoxin subunit 2694935 hcaC 7128492 hcaC Escherichia coli IAI1 3-phenylpropionate dioxygenase ferredoxin subunit YP_002387978.1 2694615 D 585034 CDS YP_002387979.1 218555066 7128488 2694932..2695744 1 NC_011741.1 Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 2695744 hcaB 7128488 hcaB Escherichia coli IAI1 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase YP_002387979.1 2694932 D 585034 CDS YP_002387980.1 218555067 7128490 2696980..2697474 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2697474 yphA 7128490 yphA Escherichia coli IAI1 hypothetical protein YP_002387980.1 2696980 D 585034 CDS YP_002387981.1 218555068 7124326 complement(2697522..2698394) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2698394 yphB 7124326 yphB Escherichia coli IAI1 hypothetical protein YP_002387981.1 2697522 R 585034 CDS YP_002387982.1 218555069 7124327 complement(2698406..2699467) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 2699467 yphC 7124327 yphC Escherichia coli IAI1 putative oxidoreductase YP_002387982.1 2698406 R 585034 CDS YP_002387983.1 218555070 7124328 complement(2699533..2700531) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter membrane protein 2700531 yphD 7124328 yphD Escherichia coli IAI1 putative sugar ABC transporter membrane protein YP_002387983.1 2699533 R 585034 CDS YP_002387984.1 218555071 7124329 complement(2700556..2702067) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter ATP-binding protein 2702067 yphE 7124329 yphE Escherichia coli IAI1 putative sugar ABC transporter ATP-binding protein YP_002387984.1 2700556 R 585034 CDS YP_002387985.1 218555072 7124330 complement(2702090..2703073) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pt : putative transporter; putative sugar ABC transporter periplasmic-binding protein 2703073 yphF 7124330 yphF Escherichia coli IAI1 putative sugar ABC transporter periplasmic-binding protein YP_002387985.1 2702090 R 585034 CDS YP_002387986.1 218555073 7124331 complement(2703170..2706451) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2706451 yphG 7124331 yphG Escherichia coli IAI1 hypothetical protein YP_002387986.1 2703170 R 585034 CDS YP_002387987.1 218555074 7124332 2706569..2707762 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2707762 yphH 7124332 yphH Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002387987.1 2706569 D 585034 CDS YP_002387988.1 218555075 7124333 complement(2707826..2709079) 1 NC_011741.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 2709079 glyA 7124333 glyA Escherichia coli IAI1 serine hydroxymethyltransferase YP_002387988.1 2707826 R 585034 CDS YP_002387989.1 218555076 7128358 2709408..2710598 1 NC_011741.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 2710598 hmp 7128358 hmp Escherichia coli IAI1 nitric oxide dioxygenase YP_002387989.1 2709408 D 585034 CDS YP_002387990.1 218555077 7125285 complement(2710643..2710981) 1 NC_011741.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 2710981 glnB 7125285 glnB Escherichia coli IAI1 nitrogen regulatory protein P-II 1 YP_002387990.1 2710643 R 585034 CDS YP_002387991.1 218555078 7128322 complement(2711042..2712376) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8226691, 8412694; Product type pr : putative regulator; putative DNA-binding response regulator in two-component system 2712376 yfhA 7128322 yfhA Escherichia coli IAI1 putative DNA-binding response regulator in two-component system YP_002387991.1 2711042 R 585034 CDS YP_002387992.1 218555079 7125868 complement(2712366..2713079) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2713079 yfhG 7125868 yfhG Escherichia coli IAI1 hypothetical protein YP_002387992.1 2712366 R 585034 CDS YP_002387993.1 218555080 7125871 2713013..2713177 1 NC_011741.1 hypothetical protein 2713177 7125871 ECIAI1_2609 Escherichia coli IAI1 hypothetical protein YP_002387993.1 2713013 D 585034 CDS YP_002387994.1 218555081 7127725 complement(2713243..2714670) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative sensory kinase in two-component system 2714670 yfhK 7127725 yfhK Escherichia coli IAI1 putative sensory kinase in two-component system YP_002387994.1 2713243 R 585034 CDS YP_002387995.1 218555082 7127450 complement(2715246..2719133) 1 NC_011741.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 2719133 purL 7127450 purL Escherichia coli IAI1 phosphoribosylformylglycinamidine synthase YP_002387995.1 2715246 R 585034 CDS YP_002387996.1 218555083 7126552 2719529..2720947 1 NC_011741.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; putative transglycosylase 2720947 yfhD 7126552 yfhD Escherichia coli IAI1 putative transglycosylase YP_002387996.1 2719529 D 585034 CDS YP_002387997.1 218555084 7125870 complement(2720944..2721480) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12110595; Product type e : enzyme; tRNA-specific adenosine deaminase 2721480 tadA 7125870 tadA Escherichia coli IAI1 tRNA-specific adenosine deaminase YP_002387997.1 2720944 R 585034 CDS YP_002387998.1 218555085 7126206 complement(2721505..2722140) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2722140 yfhB 7126206 yfhB Escherichia coli IAI1 hypothetical protein YP_002387998.1 2721505 R 585034 CDS YP_002387999.1 218555086 7125869 2722349..2723197 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2723197 yfhH 7125869 yfhH Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002387999.1 2722349 D 585034 CDS YP_002388000.1 218555087 7125872 2723342..2723773 1 NC_011741.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2723773 7125872 ECIAI1_2617 Escherichia coli IAI1 hypothetical protein YP_002388000.1 2723342 D 585034 CDS YP_002388001.1 218555088 7127726 2723832..2724479 1 NC_011741.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2724479 7127726 ECIAI1_2618 Escherichia coli IAI1 hypothetical protein YP_002388001.1 2723832 D 585034 CDS YP_002388002.1 218555089 7127727 2724712..2724858 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 2724858 7127727 ECIAI1_2619 Escherichia coli IAI1 hypothetical protein YP_002388002.1 2724712 D 585034 CDS YP_002388003.1 218555090 7127728 2725054..2726121 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative O-acyltransferase, transmembrane 2726121 7127728 ECIAI1_2620 Escherichia coli IAI1 putative O-acyltransferase, transmembrane YP_002388003.1 2725054 D 585034 CDS YP_002388004.1 218555091 7127729 complement(2726377..2726817) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail fiber assembly protein 2726817 7127729 ECIAI1_2621 Escherichia coli IAI1 putative phage tail fiber assembly protein YP_002388004.1 2726377 R 585034 CDS YP_002388005.1 218555092 7127730 complement(2726793..2727878) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative bacteriophage protein 2727878 7127730 ECIAI1_2622 Escherichia coli IAI1 putative bacteriophage protein YP_002388005.1 2726793 R 585034 CDS YP_002388006.1 218555093 7127731 complement(2726843..2727016) 1 NC_011741.1 hypothetical protein 2727016 7127731 ECIAI1_2623 Escherichia coli IAI1 hypothetical protein YP_002388006.1 2726843 R 585034 CDS YP_002388007.1 218555094 7127732 complement(2727860..2728540) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2728540 7127732 ECIAI1_2624 Escherichia coli IAI1 hypothetical protein YP_002388007.1 2727860 R 585034 CDS YP_002388008.1 218555095 7127733 complement(2728537..2729736) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2729736 7127733 ECIAI1_2625 Escherichia coli IAI1 hypothetical protein YP_002388008.1 2728537 R 585034 CDS YP_002388009.1 218555096 7127734 complement(2729736..2730089) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2730089 7127734 ECIAI1_2626 Escherichia coli IAI1 hypothetical protein YP_002388009.1 2729736 R 585034 CDS YP_002388010.1 218555097 7127735 complement(2730089..2730841) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2730841 7127735 ECIAI1_2627 Escherichia coli IAI1 hypothetical protein YP_002388010.1 2730089 R 585034 CDS YP_002388011.1 218555098 7127736 complement(2730903..2731082) 1 NC_011741.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2731082 7127736 ECIAI1_2628 Escherichia coli IAI1 hypothetical protein YP_002388011.1 2730903 R 585034 CDS YP_002388012.1 218555099 7127737 complement(2731616..2731969) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; hypothetical protein 2731969 7127737 ECIAI1_2629 Escherichia coli IAI1 hypothetical protein YP_002388012.1 2731616 R 585034 CDS YP_002388013.1 218555100 7127738 complement(2731969..2733036) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2733036 7127738 ECIAI1_2630 Escherichia coli IAI1 hypothetical protein YP_002388013.1 2731969 R 585034 CDS YP_002388014.1 218555101 7127739 complement(2733039..2733341) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2733341 7127739 ECIAI1_2631 Escherichia coli IAI1 hypothetical protein YP_002388014.1 2733039 R 585034 CDS YP_002388015.1 218555102 7127740 complement(2733341..2733928) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2733928 7127740 ECIAI1_2632 Escherichia coli IAI1 hypothetical protein YP_002388015.1 2733341 R 585034 CDS YP_002388016.1 218555103 7127741 complement(2733928..2735934) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2735934 7127741 ECIAI1_2633 Escherichia coli IAI1 hypothetical protein YP_002388016.1 2733928 R 585034 CDS YP_002388017.1 218555104 7127742 complement(2736090..2736542) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2736542 7127742 ECIAI1_2634 Escherichia coli IAI1 hypothetical protein YP_002388017.1 2736090 R 585034 CDS YP_002388018.1 218555105 7127743 complement(2736546..2736986) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2736986 7127743 ECIAI1_2635 Escherichia coli IAI1 hypothetical protein YP_002388018.1 2736546 R 585034 CDS YP_002388019.1 218555106 7127744 complement(2736997..2738142) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2738142 7127744 ECIAI1_2636 Escherichia coli IAI1 hypothetical protein YP_002388019.1 2736997 R 585034 CDS YP_002388020.1 218555107 7127745 complement(2738146..2738712) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2738712 7127745 ECIAI1_2637 Escherichia coli IAI1 hypothetical protein YP_002388020.1 2738146 R 585034 CDS YP_002388021.1 218555108 7127746 complement(2738684..2739073) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2739073 7127746 ECIAI1_2638 Escherichia coli IAI1 hypothetical protein YP_002388021.1 2738684 R 585034 CDS YP_002388022.1 218555109 7127747 complement(2739060..2739614) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2739614 7127747 ECIAI1_2639 Escherichia coli IAI1 hypothetical protein YP_002388022.1 2739060 R 585034 CDS YP_002388023.1 218555110 7127748 complement(2739611..2740018) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2740018 7127748 ECIAI1_2640 Escherichia coli IAI1 hypothetical protein YP_002388023.1 2739611 R 585034 CDS YP_002388024.1 218555111 7127749 complement(2739984..2740205) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2740205 7127749 ECIAI1_2641 Escherichia coli IAI1 hypothetical protein YP_002388024.1 2739984 R 585034 CDS YP_002388025.1 218555112 7127750 complement(2740247..2741188) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2741188 7127750 ECIAI1_2642 Escherichia coli IAI1 hypothetical protein YP_002388025.1 2740247 R 585034 CDS YP_002388026.1 218555113 7127751 complement(2741200..2741706) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2741706 7127751 ECIAI1_2643 Escherichia coli IAI1 hypothetical protein YP_002388026.1 2741200 R 585034 CDS YP_002388027.1 218555114 7127752 complement(2741710..2742930) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2742930 7127752 ECIAI1_2644 Escherichia coli IAI1 hypothetical protein YP_002388027.1 2741710 R 585034 CDS YP_002388028.1 218555115 7127753 complement(2742945..2743718) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2743718 7127753 ECIAI1_2645 Escherichia coli IAI1 hypothetical protein YP_002388028.1 2742945 R 585034 CDS YP_002388029.1 218555116 7127754 complement(2743567..2745036) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2745036 7127754 ECIAI1_2646 Escherichia coli IAI1 hypothetical protein YP_002388029.1 2743567 R 585034 CDS YP_002388030.1 218555117 7127755 complement(2745036..2746658) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2746658 7127755 ECIAI1_2647 Escherichia coli IAI1 hypothetical protein YP_002388030.1 2745036 R 585034 CDS YP_002388031.1 218555118 7127756 complement(2746661..2747233) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Terminase small subunit 2747233 7127756 ECIAI1_2648 Escherichia coli IAI1 putative Terminase small subunit YP_002388031.1 2746661 R 585034 CDS YP_002388032.1 218555119 7127757 complement(2747295..2747819) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative exported protein from phage origin 2747819 7127757 ECIAI1_2649 Escherichia coli IAI1 putative exported protein from phage origin YP_002388032.1 2747295 R 585034 CDS YP_002388033.1 218555120 7127758 complement(2747803..2748279) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Lysozyme 2748279 r 7127758 r Escherichia coli IAI1 Lysozyme YP_002388033.1 2747803 R 585034 CDS YP_002388034.1 218555121 7126585 complement(2748283..2748642) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2998005; Product type h : extrachromosomal origin; Holin 2748642 S 7126585 S Escherichia coli IAI1 Holin YP_002388034.1 2748283 R 585034 CDS YP_002388035.1 218555122 7124668 complement(2749028..2749462) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; antitermination protein Q (P5) 2749462 Q 7124668 Q Escherichia coli IAI1 antitermination protein Q (P5) YP_002388035.1 2749028 R 585034 CDS YP_002388036.1 218555123 7126578 complement(2749649..2749846) 1 NC_011741.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2749846 7126578 ECIAI1_2653 Escherichia coli IAI1 hypothetical protein YP_002388036.1 2749649 R 585034 CDS YP_002388037.1 218555124 7127759 complement(2749749..2751935) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2751935 7127759 ECIAI1_2654 Escherichia coli IAI1 hypothetical protein YP_002388037.1 2749749 R 585034 CDS YP_002388038.1 218555125 7127760 complement(2751939..2752139) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative protein P2 from bacteriophage origin (fragment) 2752139 7127760 ECIAI1_2655 Escherichia coli IAI1 putative protein P2 from bacteriophage origin (fragment) YP_002388038.1 2751939 R 585034 CDS YP_002388039.1 218555126 7127761 2752281..2752955 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10489345; Product type f : factor; putative repressor CI from bacteriophage origin 2752955 7127761 ECIAI1_2656 Escherichia coli IAI1 putative repressor CI from bacteriophage origin YP_002388039.1 2752281 D 585034 CDS YP_002388040.1 218555127 7127762 complement(2753013..2753237) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 2753237 7127762 ECIAI1_2657 Escherichia coli IAI1 hypothetical protein YP_002388040.1 2753013 R 585034 CDS YP_002388041.1 218555128 7127763 complement(2753374..2753898) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative coiled-coil protein from phage origin 2753898 7127763 ECIAI1_2658 Escherichia coli IAI1 putative coiled-coil protein from phage origin YP_002388041.1 2753374 R 585034 CDS YP_002388042.1 218555129 7125497 2754091..2754261 1 NC_011741.1 Evidence 6 : Doubtful CDS; Product type h : extrachromosomal origin; hypothetical protein 2754261 7125497 ECIAI1_2659 Escherichia coli IAI1 hypothetical protein YP_002388042.1 2754091 D 585034 CDS YP_002388043.1 218555130 7127765 2754258..2755160 1 NC_011741.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2755160 7127765 ECIAI1_2660 Escherichia coli IAI1 hypothetical protein YP_002388043.1 2754258 D 585034 CDS YP_002388044.1 218555131 7127766 2755163..2756464 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10489345; hypothetical protein 2756464 7127766 ECIAI1_2661 Escherichia coli IAI1 hypothetical protein YP_002388044.1 2755163 D 585034 CDS YP_002388045.1 218555132 7127767 2756480..2757028 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2757028 7127767 ECIAI1_2662 Escherichia coli IAI1 hypothetical protein YP_002388045.1 2756480 D 585034 CDS YP_002388046.1 218555133 7127768 complement(2757081..2757710) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 2757710 7127768 ECIAI1_2663 Escherichia coli IAI1 hypothetical protein YP_002388046.1 2757081 R 585034 CDS YP_002388047.1 218555134 7127769 2757757..2759820 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10489345; Product type pe : putative enzyme; putative DNA polymerase from bacteriophage origin 2759820 7127769 ECIAI1_2664 Escherichia coli IAI1 putative DNA polymerase from bacteriophage origin YP_002388047.1 2757757 D 585034 CDS YP_002388048.1 218555135 7127770 2759885..2760646 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2760646 7127770 ECIAI1_2665 Escherichia coli IAI1 hypothetical protein YP_002388048.1 2759885 D 585034 CDS YP_002388049.1 218555136 7127771 2760881..2761075 1 NC_011741.1 hypothetical protein 2761075 7127771 ECIAI1_2666 Escherichia coli IAI1 hypothetical protein YP_002388049.1 2760881 D 585034 CDS YP_002388050.1 218555137 7127772 2761075..2761362 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10489345; Product type h : extrachromosomal origin; hypothetical protein 2761362 7127772 ECIAI1_2667 Escherichia coli IAI1 hypothetical protein YP_002388050.1 2761075 D 585034 CDS YP_002388051.1 218555138 7127773 complement(2761375..2762172) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 2762172 7127773 ECIAI1_2668 Escherichia coli IAI1 hypothetical protein YP_002388051.1 2761375 R 585034 CDS YP_002388052.1 218555139 7127774 2762240..2763634 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10489345; Product type h : extrachromosomal origin; hypothetical protein 2763634 7127774 ECIAI1_2669 Escherichia coli IAI1 hypothetical protein YP_002388052.1 2762240 D 585034 CDS YP_002388053.1 218555140 7127775 2763631..2763831 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2763831 7127775 ECIAI1_2670 Escherichia coli IAI1 hypothetical protein YP_002388053.1 2763631 D 585034 CDS YP_002388054.1 218555141 7128527 complement(2763828..2765231) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; hypothetical protein 2765231 7128527 ECIAI1_2671 Escherichia coli IAI1 hypothetical protein YP_002388054.1 2763828 R 585034 CDS YP_002388055.1 218555142 7128528 2765440..2765700 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8765743, 8880900; Product type c : carrier; ferredoxin 2765700 yfhL 7128528 yfhL Escherichia coli IAI1 ferredoxin YP_002388055.1 2765440 D 585034 CDS YP_002388056.1 218555143 7124658 complement(2765971..2766135) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2766135 7124658 ECIAI1_2673 Escherichia coli IAI1 hypothetical protein YP_002388056.1 2765971 R 585034 CDS YP_002388057.1 218555144 7124659 complement(2766395..2766775) 1 NC_011741.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 2766775 acpS 7124659 acpS Escherichia coli IAI1 4'-phosphopantetheinyl transferase YP_002388057.1 2766395 R 585034 CDS YP_002388058.1 218555145 7125704 complement(2766775..2767506) 1 NC_011741.1 involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase 2767506 pdxJ 7125704 pdxJ Escherichia coli IAI1 pyridoxine 5'-phosphate synthase YP_002388058.1 2766775 R 585034 CDS YP_002388059.1 218555146 7124166 complement(2767518..2768246) 1 NC_011741.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 2768246 recO 7124166 recO Escherichia coli IAI1 DNA repair protein RecO YP_002388059.1 2767518 R 585034 CDS YP_002388060.1 218555147 7124953 complement(2768258..2769163) 1 NC_011741.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 2769163 era 7124953 era Escherichia coli IAI1 GTP-binding protein Era YP_002388060.1 2768258 R 585034 CDS YP_002388061.1 218555148 7125088 complement(2769160..2769840) 1 NC_011741.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 2769840 rnc 7125088 rnc Escherichia coli IAI1 ribonuclease III YP_002388061.1 2769160 R 585034 CDS YP_002388062.1 218555149 7125498 complement(2770113..2771087) 1 NC_011741.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I 2771087 lepB 7125498 lepB Escherichia coli IAI1 signal peptidase I YP_002388062.1 2770113 R 585034 CDS YP_002388063.1 218555150 7126406 complement(2771103..2772902) 1 NC_011741.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 2772902 lepA 7126406 lepA Escherichia coli IAI1 GTP-binding protein LepA YP_002388063.1 2771103 R 585034 CDS YP_002388064.1 218555151 7126405 2773036..2773170 1 NC_011741.1 hypothetical protein 2773170 7126405 ECIAI1_2682 Escherichia coli IAI1 hypothetical protein YP_002388064.1 2773036 D 585034 CDS YP_002388065.1 218555152 7128530 complement(2773100..2773579) 1 NC_011741.1 involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC 2773579 rseC 7128530 rseC Escherichia coli IAI1 SoxR reducing system protein RseC YP_002388065.1 2773100 R 585034 CDS YP_002388066.1 218555153 7128434 complement(2773576..2774532) 1 NC_011741.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE 2774532 rseB 7128434 rseB Escherichia coli IAI1 periplasmic negative regulator of sigmaE YP_002388066.1 2773576 R 585034 CDS YP_002388067.1 218555154 7128433 complement(2774532..2775182) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9159522, 97303092, 99431977, 7768826; Product type f : factor; anti-RNA polymerase sigma factor SigE 2775182 rseA 7128433 rseA Escherichia coli IAI1 anti-RNA polymerase sigma factor SigE YP_002388067.1 2774532 R 585034 CDS YP_002388068.1 218555155 7128432 complement(2775215..2775790) 1 NC_011741.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 2775790 rpoE 7128432 rpoE Escherichia coli IAI1 RNA polymerase sigma factor RpoE YP_002388068.1 2775215 R 585034 CDS YP_002388069.1 218555156 7128400 2776198..2777820 1 NC_011741.1 catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 2777820 nadB 7128400 nadB Escherichia coli IAI1 L-aspartate oxidase YP_002388069.1 2776198 D 585034 CDS YP_002388070.1 218555157 7124512 complement(2777805..2778542) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase 2778542 yfiC 7124512 yfiC Escherichia coli IAI1 putative S-adenosyl-L-methionine-dependent methyltransferase YP_002388070.1 2777805 R 585034 CDS YP_002388071.1 218555158 7125881 2778674..2780008 1 NC_011741.1 facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2780008 srmB 7125881 srmB Escherichia coli IAI1 ATP-dependent RNA helicase SrmB YP_002388071.1 2778674 D 585034 CDS YP_002388072.1 218555159 7127976 2780279..2781259 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 2781259 7127976 ECIAI1_2692 Escherichia coli IAI1 transposase, IS110 family YP_002388072.1 2780279 D 585034 CDS YP_002388073.1 218555160 7128531 complement(2781496..2782377) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2782377 yfiE 7128531 yfiE Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002388073.1 2781496 R 585034 CDS YP_002388074.1 218555161 7125883 2782480..2783067 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12562784; Product type t : transporter; neutral amino-acid efflux protein 2783067 yfiK 7125883 yfiK Escherichia coli IAI1 neutral amino-acid efflux protein YP_002388074.1 2782480 D 585034 CDS YP_002388075.1 218555162 7125886 complement(2783123..2783506) 1 NC_011741.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA 2783506 yfiD 7125886 yfiD Escherichia coli IAI1 autonomous glycyl radical cofactor GrcA YP_002388075.1 2783123 R 585034 CDS YP_002388076.1 218555163 7125882 2783811..2784500 1 NC_011741.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2784500 ung 7125882 ung Escherichia coli IAI1 uracil-DNA glycosylase YP_002388076.1 2783811 D 585034 CDS YP_002388077.1 218555164 7125545 complement(2784548..2785585) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase 2785585 yfiF 7125545 yfiF Escherichia coli IAI1 putative methyltransferase YP_002388077.1 2784548 R 585034 CDS YP_002388078.1 218555165 7125884 complement(2785575..2785778) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2785778 7125884 ECIAI1_2699 Escherichia coli IAI1 hypothetical protein YP_002388078.1 2785575 R 585034 CDS YP_002388079.1 218555166 7128532 2785792..2786211 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12952960, 9388228, 99175138, 10644706; Product type c : carrier; thioredoxin 2 2786211 trxC 7128532 trxC Escherichia coli IAI1 thioredoxin 2 YP_002388079.1 2785792 D 585034 CDS YP_002388080.1 218555167 7127508 2786280..2786978 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2786978 yfiP 7127508 yfiP Escherichia coli IAI1 hypothetical protein YP_002388080.1 2786280 D 585034 CDS YP_002388081.1 218555168 7125891 2787010..2789670 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; acyl-CoA synthetase NAD(P)-binding/ATP-binding subunit 2789670 yfiQ 7125891 yfiQ Escherichia coli IAI1 acyl-CoA synthetase NAD(P)-binding/ATP-binding subunit YP_002388081.1 2787010 D 585034 CDS YP_002388082.1 218555169 7125892 2789784..2791139 1 NC_011741.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 2791139 pssA 7125892 pssA Escherichia coli IAI1 phosphatidylserine synthase YP_002388082.1 2789784 D 585034 CDS YP_002388083.1 218555170 7126529 2791236..2791508 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2791508 yfiM 7126529 yfiM Escherichia coli IAI1 hypothetical protein YP_002388083.1 2791236 D 585034 CDS YP_002388084.1 218555171 7125888 complement(2791505..2792803) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91219460, 1709493, 2053984, 2118499, 2190187, 8419306; Product type t : transporter; alpha-ketoglutarate transporter 2792803 kgtP 7125888 kgtP Escherichia coli IAI1 alpha-ketoglutarate transporter YP_002388084.1 2791505 R 585034 CDS YP_002388085.1 218555172 7126787 complement(2798666..2801239) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14550559, 14640692, 91294166, 93015925, 93388583, 99428468; Product type f : factor; protein disaggregation chaperone 2801239 clpB 7126787 clpB Escherichia coli IAI1 protein disaggregation chaperone YP_002388085.1 2798666 R 585034 CDS YP_002388086.1 218555173 7124660 complement(2801369..2802100) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1906060, 2066329; hypothetical protein 2802100 yfiH 7124660 yfiH Escherichia coli IAI1 hypothetical protein YP_002388086.1 2801369 R 585034 CDS YP_002388087.1 218555174 7125885 complement(2802097..2803077) 1 NC_011741.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D 2803077 rluD 7125885 rluD Escherichia coli IAI1 23S rRNA pseudouridine synthase D YP_002388087.1 2802097 R 585034 CDS YP_002388088.1 218555175 7125012 2803212..2803949 1 NC_011741.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 2803949 yfiO 7125012 yfiO Escherichia coli IAI1 outer membrane protein assembly complex subunit YfiO YP_002388088.1 2803212 D 585034 CDS YP_002388089.1 218555176 7125890 2804220..2804561 1 NC_011741.1 associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 2804561 yfiA 7125890 yfiA Escherichia coli IAI1 translation inhibitor protein RaiA YP_002388089.1 2804220 D 585034 CDS YP_002388091.1 218555178 7124193 2804811..2805971 1 NC_011741.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 2805971 pheA 7124193 pheA Escherichia coli IAI1 bifunctional chorismate mutase/prephenate dehydratase YP_002388091.1 2804811 D 585034 CDS YP_002388092.1 218555179 7124192 complement(2806014..2807135) 1 NC_011741.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 2807135 tyrA 7124192 tyrA Escherichia coli IAI1 bifunctional chorismate mutase/prephenate dehydrogenase YP_002388092.1 2806014 R 585034 CDS YP_002388093.1 218555180 7127525 complement(2807146..2808216) 1 NC_011741.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 2808216 aroF 7127525 aroF Escherichia coli IAI1 phospho-2-dehydro-3-deoxyheptonate aldolase YP_002388093.1 2807146 R 585034 CDS YP_002388094.1 218555181 7125807 2808426..2808791 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6396419; hypothetical protein 2808791 yfiL 7125807 yfiL Escherichia coli IAI1 hypothetical protein YP_002388094.1 2808426 D 585034 CDS YP_002388095.1 218555182 7125887 2808941..2809459 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2809459 yfiR 7125887 yfiR Escherichia coli IAI1 hypothetical protein YP_002388095.1 2808941 D 585034 CDS YP_002388096.1 218555183 7125893 2809449..2810675 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; hypothetical protein 2810675 yfiN 7125893 yfiN Escherichia coli IAI1 hypothetical protein YP_002388096.1 2809449 D 585034 CDS YP_002388097.1 218555184 7125889 2810691..2811173 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96032391; Product type pm : putative membrane component; putative outer membrane lipoprotein 2811173 yfiB 7125889 yfiB Escherichia coli IAI1 putative outer membrane lipoprotein YP_002388097.1 2810691 D 585034 CDS YP_002388098.1 218555185 7125880 complement(2811250..2811597) 1 NC_011741.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 2811597 rplS 7125880 rplS Escherichia coli IAI1 50S ribosomal protein L19 YP_002388098.1 2811250 R 585034 CDS YP_002388099.1 218555186 7128380 complement(2811639..2812406) 1 NC_011741.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 2812406 trmD 7128380 trmD Escherichia coli IAI1 tRNA (guanine-N(1)-)-methyltransferase YP_002388099.1 2811639 R 585034 CDS YP_002388100.1 218555187 7127490 complement(2812437..2812985) 1 NC_011741.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 2812985 rimM 7127490 rimM Escherichia coli IAI1 16S rRNA-processing protein RimM YP_002388100.1 2812437 R 585034 CDS YP_002388101.1 218555188 7125005 complement(2813004..2813252) 1 NC_011741.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 2813252 rpsP 7125005 rpsP Escherichia coli IAI1 30S ribosomal protein S16 YP_002388101.1 2813004 R 585034 CDS YP_002388102.1 218555189 7128422 complement(2813363..2813536) 1 NC_011741.1 hypothetical protein 2813536 7128422 ECIAI1_2731 Escherichia coli IAI1 hypothetical protein YP_002388102.1 2813363 R 585034 CDS YP_002388103.1 218555190 7128533 complement(2813389..2814750) 1 NC_011741.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein 2814750 ffh 7128533 ffh Escherichia coli IAI1 signal recognition particle protein YP_002388103.1 2813389 R 585034 CDS YP_002388104.1 218555191 7127094 2814842..2815708 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2815708 ypjD 7127094 ypjD Escherichia coli IAI1 hypothetical protein YP_002388104.1 2814842 D 585034 CDS YP_002388105.1 218555192 7124337 2815819..2817015 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2817015 yfjD 7124337 yfjD Escherichia coli IAI1 hypothetical protein YP_002388105.1 2815819 D 585034 CDS YP_002388106.1 218555193 7125895 complement(2817070..2817663) 1 NC_011741.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 2817663 grpE 7125895 grpE Escherichia coli IAI1 heat shock protein GrpE YP_002388106.1 2817070 R 585034 CDS YP_002388107.1 218555194 7128467 2817786..2818664 1 NC_011741.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 2818664 ppnK 7128467 ppnK Escherichia coli IAI1 inorganic polyphosphate/ATP-NAD kinase YP_002388107.1 2817786 D 585034 CDS YP_002388108.1 218555195 7125894 2818750..2820411 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87259985, 91355307, 95058623, 3037486; Product type cp : cell process; recombination and repair protein 2820411 recN 7125894 recN Escherichia coli IAI1 recombination and repair protein YP_002388108.1 2818750 D 585034 CDS YP_002388109.1 218555196 7124952 2820560..2820901 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2045357; Product type lp : lipoprotein; hypothetical protein 2820901 smpA 7124952 smpA Escherichia coli IAI1 hypothetical protein YP_002388109.1 2820560 D 585034 CDS YP_002388110.1 218555197 7127938 complement(2820963..2821253) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2821253 yfjF 7127938 yfjF Escherichia coli IAI1 hypothetical protein YP_002388110.1 2820963 R 585034 CDS YP_002388111.1 218555198 7125896 complement(2821243..2821719) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2821719 yfjG 7125896 yfjG Escherichia coli IAI1 hypothetical protein YP_002388111.1 2821243 R 585034 CDS YP_002388112.1 218555199 7125897 2821851..2822333 1 NC_011741.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 2822333 smpB 7125897 smpB Escherichia coli IAI1 SsrA-binding protein YP_002388112.1 2821851 D 585034 CDS YP_002388113.1 218555200 7124335 2825329..2825592 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15126494, 7737514; Product type pe : putative enzyme; transposase, ORF A, IS3 family, IS407 group 2825592 7124335 ECIAI1_2745 Escherichia coli IAI1 transposase, ORF A, IS3 family, IS407 group YP_002388113.1 2825329 D 585034 CDS YP_002388114.1 218555201 7128534 2825616..2826449 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1718819, 7737514; Product type pe : putative enzyme; transposase, ORF B, IS3 family, IS407 group 2826449 7128534 ECIAI1_2746 Escherichia coli IAI1 transposase, ORF B, IS3 family, IS407 group YP_002388114.1 2825616 D 585034 CDS YP_002388115.1 218555202 7124336 complement(2827827..2828084) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative DNA invertase fragment pinH 2828084 7124336 ECIAI1_2748 Escherichia coli IAI1 putative DNA invertase fragment pinH YP_002388115.1 2827827 R 585034 CDS YP_002388116.1 218555203 7128536 2827870..2828343 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 2828343 7128536 ECIAI1_2749 Escherichia coli IAI1 hypothetical protein YP_002388116.1 2827870 D 585034 CDS YP_002388117.1 218555204 7128539 complement(2830362..2830691) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 2830691 7128539 ECIAI1_2752 Escherichia coli IAI1 hypothetical protein YP_002388117.1 2830362 R 585034 CDS YP_002388118.1 218555205 7128045 2831233..2833074 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative alpha-amylase 2833074 7128045 ECIAI1_2753 Escherichia coli IAI1 putative alpha-amylase YP_002388118.1 2831233 D 585034 CDS YP_002388119.1 218555206 7128541 2833213..2833485 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2833485 yqaD 7128541 yqaD Escherichia coli IAI1 hypothetical protein YP_002388119.1 2833213 D 585034 CDS YP_002388120.1 218555207 7124340 2833821..2834798 1 NC_011741.1 in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 2834798 ygaT 7124340 ygaT Escherichia coli IAI1 hypothetical protein YP_002388120.1 2833821 D 585034 CDS YP_002388121.1 218555208 7125904 2834818..2836086 1 NC_011741.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 2836086 ygaF 7125904 ygaF Escherichia coli IAI1 hydroxyglutarate oxidase YP_002388121.1 2834818 D 585034 CDS YP_002388122.1 218555209 7125900 2836109..2837557 1 NC_011741.1 catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; succinate-semialdehyde dehydrogenase I 2837557 gabD 7125900 gabD Escherichia coli IAI1 succinate-semialdehyde dehydrogenase I YP_002388122.1 2836109 D 585034 CDS YP_002388123.1 218555210 7128258 2837571..2838851 1 NC_011741.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 2838851 gabT 7128258 gabT Escherichia coli IAI1 4-aminobutyrate aminotransferase YP_002388123.1 2837571 D 585034 CDS YP_002388124.1 218555211 7128260 2839162..2840562 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94127927, 9685361, 8297211; Product type t : transporter; gamma-aminobutyrate transporter 2840562 gabP 7128260 gabP Escherichia coli IAI1 gamma-aminobutyrate transporter YP_002388124.1 2839162 D 585034 CDS YP_002388125.1 218555212 7128259 2840583..2841245 1 NC_011741.1 regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 2841245 csiR 7128259 csiR Escherichia coli IAI1 DNA-binding transcriptional regulator CsiR YP_002388125.1 2840583 D 585034 CDS YP_002388126.1 218555213 7125930 complement(2841246..2841695) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; LysM domain/BON superfamily protein 2841695 ygaU 7125930 ygaU Escherichia coli IAI1 LysM domain/BON superfamily protein YP_002388126.1 2841246 R 585034 CDS YP_002388127.1 218555214 7125905 complement(2841779..2841937) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2841937 yqaE 7125905 yqaE Escherichia coli IAI1 hypothetical protein YP_002388127.1 2841779 R 585034 CDS YP_002388128.1 218555215 7124341 2842120..2842419 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2842419 ygaV 7124341 ygaV Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002388128.1 2842120 D 585034 CDS YP_002388129.1 218555216 7125906 2842429..2842953 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : putative enzyme; hypothetical protein 2842953 ygaP 7125906 ygaP Escherichia coli IAI1 hypothetical protein YP_002388129.1 2842429 D 585034 CDS YP_002388130.1 218555217 7125903 complement(2843000..2843404) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20485613, 93126121, 9643551, 98132400, 99415935, 1480493, 7961433; Product type r : regulator; DNA binding protein, nucleoid-associated 2843404 stpA 7125903 stpA Escherichia coli IAI1 DNA binding protein, nucleoid-associated YP_002388130.1 2843000 R 585034 CDS YP_002388131.1 218555218 7126187 2844072..2844521 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2844521 ygaW 7126187 ygaW Escherichia coli IAI1 hypothetical protein YP_002388131.1 2844072 D 585034 CDS YP_002388132.1 218555219 7125907 complement(2844558..2844902) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7961433; hypothetical protein 2844902 ygaC 7125907 ygaC Escherichia coli IAI1 hypothetical protein YP_002388132.1 2844558 R 585034 CDS YP_002388133.1 218555220 7125898 2845042..2845383 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2845383 ygaM 7125898 ygaM Escherichia coli IAI1 hypothetical protein YP_002388133.1 2845042 D 585034 CDS YP_002388134.1 218555221 7125902 2845631..2845876 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9218434, 11441020, 8820648; Product type pc : putative carrier; glutaredoxin-like protein 2845876 nrdH 7125902 nrdH Escherichia coli IAI1 glutaredoxin-like protein YP_002388134.1 2845631 D 585034 CDS YP_002388135.1 218555222 7125939 2845873..2846283 1 NC_011741.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 2846283 nrdI 7125939 nrdI Escherichia coli IAI1 ribonucleotide reductase stimulatory protein YP_002388135.1 2845873 D 585034 CDS YP_002388136.1 218555223 7125940 2846256..2848400 1 NC_011741.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2848400 nrdE 7125940 nrdE Escherichia coli IAI1 ribonucleotide-diphosphate reductase subunit alpha YP_002388136.1 2846256 D 585034 CDS YP_002388137.1 218555224 7127903 2848410..2849369 1 NC_011741.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 2849369 nrdF 7127903 nrdF Escherichia coli IAI1 ribonucleotide-diphosphate reductase subunit beta YP_002388137.1 2848410 D 585034 CDS YP_002388138.1 218555225 7127856 2849724..2850926 1 NC_011741.1 with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding subunit 2850926 proV 7127856 proV Escherichia coli IAI1 glycine betaine transporter ATP-binding subunit YP_002388138.1 2849724 D 585034 CDS YP_002388139.1 218555226 7126162 2850919..2851983 1 NC_011741.1 with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 2851983 proW 7126162 proW Escherichia coli IAI1 glycine betaine transporter membrane protein YP_002388139.1 2850919 D 585034 CDS YP_002388140.1 218555227 7126163 2852040..2853032 1 NC_011741.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 2853032 proX 7126163 proX Escherichia coli IAI1 glycine betaine transporter periplasmic subunit YP_002388140.1 2852040 D 585034 CDS YP_002388141.1 218555228 7126164 2853324..2854508 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16000740; Product type pt : putative transporter; putative transport protein 2854508 7126164 ECIAI1_2776 Escherichia coli IAI1 putative transport protein YP_002388141.1 2853324 D 585034 CDS YP_002388142.1 218555229 7128542 2854632..2855369 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 2855369 ygaZ 7128542 ygaZ Escherichia coli IAI1 putative transporter YP_002388142.1 2854632 D 585034 CDS YP_002388143.1 218555230 7125908 2855359..2855694 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2855694 ygaH 7125908 ygaH Escherichia coli IAI1 hypothetical protein YP_002388143.1 2855359 D 585034 CDS YP_002388144.1 218555231 7125901 2855785..2856315 1 NC_011741.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 2856315 mprA 7125901 mprA Escherichia coli IAI1 transcriptional repressor MprA YP_002388144.1 2855785 D 585034 CDS YP_002388145.1 218555232 7124465 2856442..2857614 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 93285984, 94262163, 1409590, 8203018; Product type t : transporter; multidrug efflux system 2857614 emrA 7124465 emrA Escherichia coli IAI1 multidrug efflux system YP_002388145.1 2856442 D 585034 CDS YP_002388146.1 218555233 7125060 2857631..2859169 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 93285984, 94262163, 1409590; Product type t : transporter; multidrug efflux system protein 2859169 emrB 7125060 emrB Escherichia coli IAI1 multidrug efflux system protein YP_002388146.1 2857631 D 585034 CDS YP_002388147.1 218555234 7125061 complement(2859233..2859748) 1 NC_011741.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 2859748 luxS 7125061 luxS Escherichia coli IAI1 S-ribosylhomocysteinase YP_002388147.1 2859233 R 585034 CDS YP_002388148.1 218555235 7124272 complement(2859898..2861454) 1 NC_011741.1 involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase 2861454 gshA 7124272 gshA Escherichia coli IAI1 glutamate--cysteine ligase YP_002388148.1 2859898 R 585034 CDS YP_002388149.1 218555236 7128471 complement(2861527..2861955) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2861955 yqaA 7128471 yqaA Escherichia coli IAI1 hypothetical protein YP_002388149.1 2861527 R 585034 CDS YP_002388150.1 218555237 7124338 complement(2861952..2862518) 1 NC_011741.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase 2862518 yqaB 7124338 yqaB Escherichia coli IAI1 fructose-1-phosphatase YP_002388150.1 2861952 R 585034 CDS YP_002388151.1 218555238 7128041 complement(2863569..2863754) 1 NC_011741.1 affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator 2863754 csrA 7128041 csrA Escherichia coli IAI1 carbon storage regulator YP_002388151.1 2863569 R 585034 CDS YP_002388152.1 218555239 7126852 complement(2863989..2866619) 1 NC_011741.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 2866619 alaS 7126852 alaS Escherichia coli IAI1 alanyl-tRNA synthetase YP_002388152.1 2863989 R 585034 CDS YP_002388153.1 218555240 7125740 complement(2866747..2867247) 1 NC_011741.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 2867247 recX 7125740 recX Escherichia coli IAI1 recombination regulator RecX YP_002388153.1 2866747 R 585034 CDS YP_002388154.1 218555241 7124956 complement(2867490..2868551) 1 NC_011741.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 2868551 recA 7124956 recA Escherichia coli IAI1 recombinase A YP_002388154.1 2867490 R 585034 CDS YP_002388155.1 218555242 7127612 complement(2868631..2869128) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A 2869128 ygaD 7127612 ygaD Escherichia coli IAI1 competence damage-inducible protein A YP_002388155.1 2868631 R 585034 CDS YP_002388156.1 218555243 7125899 complement(2869273..2870358) 1 NC_011741.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B 2870358 mltB 7125899 mltB Escherichia coli IAI1 murein hydrolase B YP_002388156.1 2869273 R 585034 CDS YP_002388157.1 218555244 7124282 2870614..2871177 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87194727, 1334233, 3553176; Product type t : transporter; glucitol/sorbitol-specific PTS system transporter subunit IIC 2871177 srlA 7124282 srlA Escherichia coli IAI1 glucitol/sorbitol-specific PTS system transporter subunit IIC YP_002388157.1 2870614 D 585034 CDS YP_002388158.1 218555245 7127971 2871174..2872133 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1100602, 3553176; Product type t : transporter; glucitol/sorbitol-specific PTS system transporter subunit IIB 2872133 srlE 7127971 srlE Escherichia coli IAI1 glucitol/sorbitol-specific PTS system transporter subunit IIB YP_002388158.1 2871174 D 585034 CDS YP_002388159.1 218555246 7127974 2872144..2872515 1 NC_011741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucitol/sorbitol-specific transporter subunit IIA 2872515 srlB 7127974 srlB Escherichia coli IAI1 PTS system glucitol/sorbitol-specific transporter subunit IIA YP_002388159.1 2872144 D 585034 CDS YP_002388160.1 218555247 7127972 2872519..2873298 1 NC_011741.1 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 2873298 srlD 7127972 srlD Escherichia coli IAI1 sorbitol-6-phosphate dehydrogenase YP_002388160.1 2872519 D 585034 CDS YP_002388161.1 218555248 7127973 2873403..2873762 1 NC_011741.1 regulator for glucitol utilization; DNA-binding transcriptional activator GutM 2873762 gutM 7127973 gutM Escherichia coli IAI1 DNA-binding transcriptional activator GutM YP_002388161.1 2873403 D 585034 CDS YP_002388162.1 218555249 7128483 2873829..2874602 1 NC_011741.1 regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 2874602 srlR 7128483 srlR Escherichia coli IAI1 DNA-binding transcriptional repressor SrlR YP_002388162.1 2873829 D 585034 CDS YP_002388163.1 218555250 7127975 2874595..2875560 1 NC_011741.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 2875560 gutQ 7127975 gutQ Escherichia coli IAI1 D-arabinose 5-phosphate isomerase YP_002388163.1 2874595 D 585034 CDS YP_002388164.1 218555251 7128484 complement(2875557..2877071) 1 NC_011741.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcription regulator 2877071 norR 7128484 norR Escherichia coli IAI1 anaerobic nitric oxide reductase transcription regulator YP_002388164.1 2875557 R 585034 CDS YP_002388165.1 218555252 7127896 2877258..2878697 1 NC_011741.1 detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 2878697 norV 7127896 norV Escherichia coli IAI1 anaerobic nitric oxide reductase flavorubredoxin YP_002388165.1 2877258 D 585034 CDS YP_002388166.1 218555253 7127897 2878694..2879827 1 NC_011741.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 2879827 norW 7127897 norW Escherichia coli IAI1 nitric oxide reductase YP_002388166.1 2878694 D 585034 CDS YP_002388167.1 218555254 7127898 complement(2880053..2882305) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12377778, 92255260, 8661925; Product type e : enzyme; carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases 2882305 hypF 7127898 hypF Escherichia coli IAI1 carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases YP_002388167.1 2880053 R 585034 CDS YP_002388168.1 218555255 7126034 complement(2882458..2882985) 1 NC_011741.1 involved in electron transport from formate to hydrogen; electron transport protein HydN 2882985 hydN 7126034 hydN Escherichia coli IAI1 electron transport protein HydN YP_002388168.1 2882458 R 585034 CDS YP_002388169.1 218555256 7125912 complement(2883134..2884147) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88297127, 92334140, 1630307; Product type r : regulator; DNA-binding transcriptional repressor 2884147 ascG 7125912 ascG Escherichia coli IAI1 DNA-binding transcriptional repressor YP_002388169.1 2883134 R 585034 CDS YP_002388170.1 218555257 7125827 2884404..2885861 1 NC_011741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC 2885861 ascF 7125827 ascF Escherichia coli IAI1 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC YP_002388170.1 2884404 D 585034 CDS YP_002388171.1 218555258 7125826 2885870..2887294 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88297127, 92334140, 1630307; Product type e : enzyme; cryptic 6-phospho-beta-glucosidase 2887294 ascB 7125826 ascB Escherichia coli IAI1 cryptic 6-phospho-beta-glucosidase YP_002388171.1 2885870 D 585034 CDS YP_002388172.1 218555259 7125825 complement(2887408..2887893) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative HTH-type transcriptional regulator ygjM 2887893 7125825 ECIAI1_2809 Escherichia coli IAI1 putative HTH-type transcriptional regulator ygjM YP_002388172.1 2887408 R 585034 CDS YP_002388173.1 218555260 7128543 complement(2887898..2888671) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2888671 7128543 ECIAI1_2810 Escherichia coli IAI1 hypothetical protein YP_002388173.1 2887898 R 585034 CDS YP_002388174.1 218555261 7128544 complement(2888696..2889166) 1 NC_011741.1 involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease 2889166 hycI 7128544 hycI Escherichia coli IAI1 hydrogenase 3 maturation protease YP_002388174.1 2888696 R 585034 CDS YP_002388175.1 218555262 7127904 complement(2889159..2889569) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 92326636, 1625581, 2187144, 7851435; Product type f : factor; hydrogenase-3 maturation protein 2889569 hycH 7127904 hycH Escherichia coli IAI1 hydrogenase-3 maturation protein YP_002388175.1 2889159 R 585034 CDS YP_002388176.1 218555263 7125347 complement(2889566..2890333) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636, 2187144; Product type e : enzyme; hydrogenase 3 and formate hydrogenase complex, HycG subunit 2890333 hycG 7125347 hycG Escherichia coli IAI1 hydrogenase 3 and formate hydrogenase complex, HycG subunit YP_002388176.1 2889566 R 585034 CDS YP_002388177.1 218555264 7125346 complement(2890333..2890875) 1 NC_011741.1 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; formate hydrogenlyase complex iron-sulfur subunit 2890875 hycF 7125346 hycF Escherichia coli IAI1 formate hydrogenlyase complex iron-sulfur subunit YP_002388177.1 2890333 R 585034 CDS YP_002388178.1 218555265 7125345 complement(2890885..2892594) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 92326636, 94170785, 2187144, 8125094; Product type e : enzyme; hydrogenase 3, large subunit 2892594 hycE 7125345 hycE Escherichia coli IAI1 hydrogenase 3, large subunit YP_002388178.1 2890885 R 585034 CDS YP_002388179.1 218555266 7125344 complement(2892612..2893535) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636; Product type m : membrane component; hydrogenase 3, membrane subunit 2893535 hycD 7125344 hycD Escherichia coli IAI1 hydrogenase 3, membrane subunit YP_002388179.1 2892612 R 585034 CDS YP_002388180.1 218555267 7125343 complement(2893538..2895364) 1 NC_011741.1 catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 2895364 hycC 7125343 hycC Escherichia coli IAI1 formate hydrogenlyase subunit 3 YP_002388180.1 2893538 R 585034 CDS YP_002388181.1 218555268 7125342 complement(2895361..2895972) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636, 2187144; Product type c : carrier; hydrogenase 3, Fe-S subunit 2895972 hycB 7125342 hycB Escherichia coli IAI1 hydrogenase 3, Fe-S subunit YP_002388181.1 2895361 R 585034 CDS YP_002388182.1 218555269 7125341 complement(2896097..2896558) 1 NC_011741.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA 2896558 hycA 7125341 hycA Escherichia coli IAI1 formate hydrogenlyase regulatory protein HycA YP_002388182.1 2896097 R 585034 CDS YP_002388183.1 218555270 7125340 2896770..2897120 1 NC_011741.1 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 2897120 hypA 7125340 hypA Escherichia coli IAI1 hydrogenase nickel incorporation protein YP_002388183.1 2896770 D 585034 CDS YP_002388184.1 218555271 7126029 2897124..2897996 1 NC_011741.1 GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 2897996 hypB 7126029 hypB Escherichia coli IAI1 hydrogenase nickel incorporation protein HypB YP_002388184.1 2897124 D 585034 CDS YP_002388185.1 218555272 7126030 2897987..2898259 1 NC_011741.1 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 2898259 hypC 7126030 hypC Escherichia coli IAI1 hydrogenase assembly chaperone YP_002388185.1 2897987 D 585034 CDS YP_002388186.1 218555273 7126031 2898259..2899380 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91194542, 92255260, 1849603; Product type f : factor; hydrogenase maturation protein 2899380 hypD 7126031 hypD Escherichia coli IAI1 hydrogenase maturation protein YP_002388186.1 2898259 D 585034 CDS YP_002388187.1 218555274 7126032 2899419..2900387 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91194542, 9485446, 1849603; Product type e : enzyme; carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein 2900387 hypE 7126032 hypE Escherichia coli IAI1 carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein YP_002388187.1 2899419 D 585034 CDS YP_002388188.1 218555275 7126033 2900461..2902539 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20307603, 21557168, 90368529, 92140045, 94018617, 2118503, 2280686; Product type r : regulator; DNA-binding transcriptional activator 2902539 fhlA 7126033 fhlA Escherichia coli IAI1 DNA-binding transcriptional activator YP_002388188.1 2900461 D 585034 CDS YP_002388189.1 218555276 7127097 complement(2902576..2902929) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2902929 ygbA 7127097 ygbA Escherichia coli IAI1 hypothetical protein YP_002388189.1 2902576 R 585034 CDS YP_002388190.1 218555277 7125909 2903216..2905777 1 NC_011741.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 2905777 mutS 7125909 mutS Escherichia coli IAI1 DNA mismatch repair protein MutS YP_002388190.1 2903216 D 585034 CDS YP_002388191.1 218555278 7124505 2905883..2906539 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9130712; Product type e : enzyme; serine/threonine-specific protein phosphatase 2 2906539 pphB 7124505 pphB Escherichia coli IAI1 serine/threonine-specific protein phosphatase 2 YP_002388191.1 2905883 D 585034 CDS YP_002388192.1 218555279 7126131 complement(2906590..2907387) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2907387 ygbI 7126131 ygbI Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002388192.1 2906590 R 585034 CDS YP_002388193.1 218555280 7125937 2907553..2908461 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dehydrogenase 2908461 ygbJ 7125937 ygbJ Escherichia coli IAI1 putative dehydrogenase YP_002388193.1 2907553 D 585034 CDS YP_002388194.1 218555281 7124866 2908458..2909720 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11520622; hypothetical protein 2909720 ygbK 7124866 ygbK Escherichia coli IAI1 hypothetical protein YP_002388194.1 2908458 D 585034 CDS YP_002388195.1 218555282 7124867 2909717..2910355 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldolase 2910355 ygbL 7124867 ygbL Escherichia coli IAI1 putative aldolase YP_002388195.1 2909717 D 585034 CDS YP_002388196.1 218555283 7124868 2910360..2911136 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2911136 ygbM 7124868 ygbM Escherichia coli IAI1 hypothetical protein YP_002388196.1 2910360 D 585034 CDS YP_002388197.1 218555284 7124869 2911225..2912589 1 NC_011741.1 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; inner membrane permease YgbN 2912589 ygbN 7124869 ygbN Escherichia coli IAI1 inner membrane permease YgbN YP_002388197.1 2911225 D 585034 CDS YP_002388198.1 218555285 7124870 complement(2912628..2912864) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme; hypothetical protein 2912864 7124870 ECIAI1_2836 Escherichia coli IAI1 hypothetical protein YP_002388198.1 2912628 R 585034 CDS YP_002388199.1 218555286 7128545 complement(2912875..2914302) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme; hypothetical protein 2914302 7128545 ECIAI1_2837 Escherichia coli IAI1 hypothetical protein YP_002388199.1 2912875 R 585034 CDS YP_002388200.1 218555287 7128546 complement(2914302..2914895) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme; hypothetical protein 2914895 7128546 ECIAI1_2838 Escherichia coli IAI1 hypothetical protein YP_002388200.1 2914302 R 585034 CDS YP_002388201.1 218555288 7128547 2915042..2915449 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15731069; Product type r : regulator; transcriptional regulator hosA 2915449 7128547 ECIAI1_2839 Escherichia coli IAI1 transcriptional regulator hosA YP_002388201.1 2915042 D 585034 CDS YP_002388202.1 218555289 7128404 complement(2916625..2917764) 1 NC_011741.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD 2917764 nlpD 7128404 nlpD Escherichia coli IAI1 lipoprotein NlpD YP_002388202.1 2916625 R 585034 CDS YP_002388203.1 218555290 7127890 complement(2917904..2918530) 1 NC_011741.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase 2918530 pcm 7127890 pcm Escherichia coli IAI1 protein-L-isoaspartate O-methyltransferase YP_002388203.1 2917904 R 585034 CDS YP_002388204.1 218555291 7124160 complement(2918524..2919285) 1 NC_011741.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 2919285 surE 7124160 surE Escherichia coli IAI1 stationary phase survival protein SurE YP_002388204.1 2918524 R 585034 CDS YP_002388205.1 218555292 7126203 complement(2919266..2920315) 1 NC_011741.1 catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D 2920315 truD 7126203 truD Escherichia coli IAI1 tRNA pseudouridine synthase D YP_002388205.1 2919266 R 585034 CDS YP_002388206.1 218555293 7127505 complement(2920312..2920791) 1 NC_011741.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 2920791 ispF 7127505 ispF Escherichia coli IAI1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_002388206.1 2920312 R 585034 CDS YP_002388207.1 218555294 7126083 complement(2920791..2921501) 1 NC_011741.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2921501 ispD 7126083 ispD Escherichia coli IAI1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_002388207.1 2920791 R 585034 CDS YP_002388208.1 218555295 7126081 complement(2921520..2921831) 1 NC_011741.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB 2921831 ftsB 7126081 ftsB Escherichia coli IAI1 cell division protein FtsB YP_002388208.1 2921520 R 585034 CDS YP_002388209.1 218555296 7128233 complement(2922025..2922348) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2922348 ygbE 7128233 ygbE Escherichia coli IAI1 hypothetical protein YP_002388209.1 2922025 R 585034 CDS YP_002388210.1 218555297 7125910 complement(2922398..2923003) 1 NC_011741.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase 2923003 cysC 7125910 cysC Escherichia coli IAI1 adenylylsulfate kinase YP_002388210.1 2922398 R 585034 CDS YP_002388211.1 218555298 7126889 complement(2923003..2924430) 1 NC_011741.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 2924430 cysN 7126889 cysN Escherichia coli IAI1 sulfate adenylyltransferase subunit 1 YP_002388211.1 2923003 R 585034 CDS YP_002388212.1 218555299 7126898 complement(2924432..2925340) 1 NC_011741.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 2925340 cysD 7126898 cysD Escherichia coli IAI1 sulfate adenylyltransferase subunit 2 YP_002388212.1 2924432 R 585034 CDS YP_002388213.1 218555300 7126890 2925592..2926629 1 NC_011741.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase isozyme conversion aminopeptidase 2926629 iap 7126890 iap Escherichia coli IAI1 alkaline phosphatase isozyme conversion aminopeptidase YP_002388213.1 2925592 D 585034 CDS YP_002388214.1 218555301 7126038 complement(2927872..2928165) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2928165 ygbF 7126038 ygbF Escherichia coli IAI1 hypothetical protein YP_002388214.1 2927872 R 585034 CDS YP_002388215.1 218555302 7125911 complement(2928162..2929121) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2929121 ygbT 7125911 ygbT Escherichia coli IAI1 hypothetical protein YP_002388215.1 2928162 R 585034 CDS YP_002388216.1 218555303 7124871 complement(2929082..2929870) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2929870 7124871 ECIAI1_2859 Escherichia coli IAI1 hypothetical protein YP_002388216.1 2929082 R 585034 CDS YP_002388217.1 218555304 7128549 complement(2929714..2930460) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2930460 7128549 ECIAI1_2860 Escherichia coli IAI1 hypothetical protein YP_002388217.1 2929714 R 585034 CDS YP_002388218.1 218555305 7128550 complement(2930471..2931526) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2931526 7128550 ECIAI1_2861 Escherichia coli IAI1 hypothetical protein YP_002388218.1 2930471 R 585034 CDS YP_002388219.1 218555306 7128551 complement(2931538..2932074) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2932074 7128551 ECIAI1_2862 Escherichia coli IAI1 hypothetical protein YP_002388219.1 2931538 R 585034 CDS YP_002388220.1 218555307 7128552 complement(2932071..2933702) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2933702 7128552 ECIAI1_2863 Escherichia coli IAI1 hypothetical protein YP_002388220.1 2932071 R 585034 CDS YP_002388221.1 218555308 7128553 complement(2933731..2936430) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2936430 7128553 ECIAI1_2864 Escherichia coli IAI1 hypothetical protein YP_002388221.1 2933731 R 585034 CDS YP_002388222.1 218555309 7128554 complement(2936624..2936776) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type pm : putative membrane component; small toxic peptide 2936776 7128554 ECIAI1_2865 Escherichia coli IAI1 small toxic peptide YP_002388222.1 2936624 R 585034 CDS YP_002388223.1 218555310 7128555 complement(2937041..2937775) 1 NC_011741.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 2937775 cysH 7128555 cysH Escherichia coli IAI1 phosphoadenosine phosphosulfate reductase YP_002388223.1 2937041 R 585034 CDS YP_002388224.1 218555311 7126893 complement(2937849..2939561) 1 NC_011741.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta 2939561 cysI 7126893 cysI Escherichia coli IAI1 sulfite reductase subunit beta YP_002388224.1 2937849 R 585034 CDS YP_002388225.1 218555312 7126894 complement(2939561..2941360) 1 NC_011741.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha 2941360 cysJ 7126894 cysJ Escherichia coli IAI1 sulfite reductase subunit alpha YP_002388225.1 2939561 R 585034 CDS YP_002388226.1 218555313 7126895 2941676..2942041 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123838; Product type e : enzyme; 6-pyruvoyl tetrahydrobiopterin synthase 2942041 ygcM 7126895 ygcM Escherichia coli IAI1 6-pyruvoyl tetrahydrobiopterin synthase YP_002388226.1 2941676 D 585034 CDS YP_002388227.1 218555314 7124874 2942119..2943390 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 2943390 ygcN 7124874 ygcN Escherichia coli IAI1 putative oxidoreductase YP_002388227.1 2942119 D 585034 CDS YP_002388228.1 218555315 7124875 2943381..2943641 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S cluster-containing protein 2943641 ygcO 7124875 ygcO Escherichia coli IAI1 putative 4Fe-4S cluster-containing protein YP_002388228.1 2943381 D 585034 CDS YP_002388229.1 218555316 7124876 2943658..2944233 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative anti-terminator regulatory protein 2944233 ygcP 7124876 ygcP Escherichia coli IAI1 putative anti-terminator regulatory protein YP_002388229.1 2943658 D 585034 CDS YP_002388230.1 218555317 7124877 complement(2944381..2945241) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative flavoprotein 2945241 ygcQ 7124877 ygcQ Escherichia coli IAI1 putative flavoprotein YP_002388230.1 2944381 R 585034 CDS YP_002388231.1 218555318 7124878 complement(2945238..2946017) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative flavoprotein 2946017 ygcR 7124878 ygcR Escherichia coli IAI1 putative flavoprotein YP_002388231.1 2945238 R 585034 CDS YP_002388232.1 218555319 7124879 complement(2945995..2947332) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 2947332 ygcS 7124879 ygcS Escherichia coli IAI1 putative transporter YP_002388232.1 2945995 R 585034 CDS YP_002388233.1 218555320 7124880 complement(2947426..2948880) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative FAD containing dehydrogenase 2948880 ygcU 7124880 ygcU Escherichia coli IAI1 putative FAD containing dehydrogenase YP_002388233.1 2947426 R 585034 CDS YP_002388234.1 218555321 7124881 complement(2948950..2949735) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative deoxygluconate dehydrogenase 2949735 ygcW 7124881 ygcW Escherichia coli IAI1 putative deoxygluconate dehydrogenase YP_002388234.1 2948950 R 585034 CDS YP_002388235.1 218555322 7124882 2950054..2951331 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 2951331 yqcE 7124882 yqcE Escherichia coli IAI1 putative transporter YP_002388235.1 2950054 D 585034 CDS YP_002388236.1 218555323 7124344 2951358..2952836 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative kinase 2952836 ygcE 7124344 ygcE Escherichia coli IAI1 putative kinase YP_002388236.1 2951358 D 585034 CDS YP_002388239.1 218555326 7128557 complement(2955124..2955795) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2955795 ygcF 7128557 ygcF Escherichia coli IAI1 hypothetical protein YP_002388239.1 2955124 R 585034 CDS YP_002388240.1 218555327 7124873 2955950..2956570 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2956570 7124873 ECIAI1_2884 Escherichia coli IAI1 hypothetical protein YP_002388240.1 2955950 D 585034 CDS YP_002388241.1 218555328 7128558 2956554..2957489 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2957489 7128558 ECIAI1_2885 Escherichia coli IAI1 hypothetical protein YP_002388241.1 2956554 D 585034 CDS YP_002388242.1 218555329 7128559 2957525..2957887 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 2957887 7128559 ECIAI1_2886 Escherichia coli IAI1 hypothetical protein YP_002388242.1 2957525 D 585034 CDS YP_002388243.1 218555330 7128560 complement(2957943..2959241) 1 NC_011741.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 2959241 eno 7128560 eno Escherichia coli IAI1 phosphopyruvate hydratase YP_002388243.1 2957943 R 585034 CDS YP_002388244.1 218555331 7125067 complement(2959329..2960966) 1 NC_011741.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 2960966 pyrG 7125067 pyrG Escherichia coli IAI1 CTP synthetase YP_002388244.1 2959329 R 585034 CDS YP_002388245.1 218555332 7126574 complement(2961194..2961985) 1 NC_011741.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase 2961985 mazG 7126574 mazG Escherichia coli IAI1 nucleoside triphosphate pyrophosphohydrolase YP_002388245.1 2961194 R 585034 CDS YP_002388246.1 218555333 7127677 complement(2962056..2962391) 1 NC_011741.1 MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA 2962391 chpA 7127677 chpA Escherichia coli IAI1 toxin ChpA YP_002388246.1 2962056 R 585034 CDS YP_002388247.1 218555334 7126315 complement(2962391..2962639) 1 NC_011741.1 part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE 2962639 chpR 7126315 chpR Escherichia coli IAI1 antitoxin MazE YP_002388247.1 2962391 R 585034 CDS YP_002388248.1 218555335 7126317 complement(2962717..2964951) 1 NC_011741.1 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase 2964951 relA 7126317 relA Escherichia coli IAI1 GDP/GTP pyrophosphokinase YP_002388248.1 2962717 R 585034 CDS YP_002388249.1 218555336 7124957 complement(2964999..2966300) 1 NC_011741.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 2966300 rumA 7124957 rumA Escherichia coli IAI1 23S rRNA 5-methyluridine methyltransferase YP_002388249.1 2964999 R 585034 CDS YP_002388250.1 218555337 7124633 2966357..2969113 1 NC_011741.1 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; hybrid sensory histidine kinase BarA 2969113 barA 7124633 barA Escherichia coli IAI1 hybrid sensory histidine kinase BarA YP_002388250.1 2966357 D 585034 CDS YP_002388251.1 218555338 7125429 complement(2969345..2970685) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20233700, 9772162, 10762278, 13971911; Product type e : enzyme; (D)-glucarate dehydratase 1 2970685 gudD 7125429 gudD Escherichia coli IAI1 (D)-glucarate dehydratase 1 YP_002388251.1 2969345 R 585034 CDS YP_002388252.1 218555339 7128480 complement(2970706..2972046) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9772162; Product type e : enzyme; glucarate dehydratase 2972046 gudX 7128480 gudX Escherichia coli IAI1 glucarate dehydratase YP_002388252.1 2970706 R 585034 CDS YP_002388253.1 218555340 7128482 complement(2972048..2973400) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10762278; Product type pt : putative transporter; putative D-glucarate transporter 2973400 gudP 7128482 gudP Escherichia coli IAI1 putative D-glucarate transporter YP_002388253.1 2972048 R 585034 CDS YP_002388254.1 218555341 7128481 complement(2973835..2974284) 1 NC_011741.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 2974284 yqcA 7128481 yqcA Escherichia coli IAI1 flavodoxin YP_002388254.1 2973835 R 585034 CDS YP_002388255.1 218555342 7124342 complement(2974302..2975084) 1 NC_011741.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C 2975084 truC 7124342 truC Escherichia coli IAI1 tRNA pseudouridine synthase C YP_002388255.1 2974302 R 585034 CDS YP_002388256.1 218555343 7127504 complement(2975084..2975413) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2975413 yqcC 7127504 yqcC Escherichia coli IAI1 hypothetical protein YP_002388256.1 2975084 R 585034 CDS YP_002388257.1 218555344 7126853 complement(2976035..2976580) 1 NC_011741.1 putative SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd 2976580 syd 7126853 syd Escherichia coli IAI1 SecY interacting protein Syd YP_002388257.1 2976035 R 585034 CDS YP_002388258.1 218555345 7126204 2976648..2977496 1 NC_011741.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 2977496 queF 7126204 queF Escherichia coli IAI1 7-cyano-7-deazaguanine reductase YP_002388258.1 2976648 D 585034 CDS YP_002388259.1 218555346 7126584 2977608..2978972 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2978972 ygdH 7126584 ygdH Escherichia coli IAI1 hypothetical protein YP_002388259.1 2977608 D 585034 CDS YP_002388260.1 218555347 7124886 2979529..2980818 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8752353, 8026499; Product type pt : putative transporter; putative serine transporter 2980818 sdaC 7124886 sdaC Escherichia coli IAI1 putative serine transporter YP_002388260.1 2979529 D 585034 CDS YP_002388261.1 218555348 7124685 2980876..2982243 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91193203, 93215657, 8385012; Product type e : enzyme; L-serine deaminase II 2982243 sdaB 7124685 sdaB Escherichia coli IAI1 L-serine deaminase II YP_002388261.1 2980876 D 585034 CDS YP_002388262.1 218555349 7124684 2982265..2983110 1 NC_011741.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 2983110 xni 7124684 xni Escherichia coli IAI1 exonuclease IX YP_002388262.1 2982265 D 585034 CDS YP_002388263.1 218555350 7127048 complement(2983165..2984316) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 89291720, 2553671, 2661535, 2664711, 8385012; Product type e : enzyme; L-1,2-propanediol oxidoreductase 2984316 fucO 7127048 fucO Escherichia coli IAI1 L-1,2-propanediol oxidoreductase YP_002388263.1 2983165 R 585034 CDS YP_002388264.1 218555351 7128248 complement(2984341..2984988) 1 NC_011741.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 2984988 fucA 7128248 fucA Escherichia coli IAI1 L-fuculose phosphate aldolase YP_002388264.1 2984341 R 585034 CDS YP_002388265.1 218555352 7128245 2985535..2986851 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 90036697, 2553671, 2664711, 7783647; Product type t : transporter; L-fucose transporter 2986851 fucP 7128245 fucP Escherichia coli IAI1 L-fucose transporter YP_002388265.1 2985535 D 585034 CDS YP_002388266.1 218555353 7128249 2986884..2988659 1 NC_011741.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 2988659 fucI 7128249 fucI Escherichia coli IAI1 L-fucose isomerase YP_002388266.1 2986884 D 585034 CDS YP_002388267.1 218555354 7128246 2988738..2990186 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 90036697, 2664711, 13905785; Product type e : enzyme; L-fuculokinase 2990186 fucK 7128246 fucK Escherichia coli IAI1 L-fuculokinase YP_002388267.1 2988738 D 585034 CDS YP_002388268.1 218555355 7128247 2990188..2990610 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15060078, 12738765, 80049526, 2664711; Product type e : enzyme; L-fucose mutarotase 2990610 fucU 7128247 fucU Escherichia coli IAI1 L-fucose mutarotase YP_002388268.1 2990188 D 585034 CDS YP_002388269.1 218555356 7128251 2990668..2991399 1 NC_011741.1 regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 2991399 fucR 7128251 fucR Escherichia coli IAI1 DNA-binding transcriptional activator FucR YP_002388269.1 2990668 D 585034 CDS YP_002388270.1 218555357 7128250 complement(2991443..2992543) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 21188420, 7704273; Product type pe : putative enzyme; putative RNA 2'-O-ribose methyltransferase 2992543 ygdE 7128250 ygdE Escherichia coli IAI1 putative RNA 2'-O-ribose methyltransferase YP_002388270.1 2991443 R 585034 CDS YP_002388271.1 218555358 7124885 complement(2992536..2992931) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7704273; Product type pm : putative membrane component; hypothetical protein 2992931 ygdD 7124885 ygdD Escherichia coli IAI1 hypothetical protein YP_002388271.1 2992536 R 585034 CDS YP_002388272.1 218555359 7124884 complement(2992950..2993867) 1 NC_011741.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA 2993867 gcvA 7124884 gcvA Escherichia coli IAI1 DNA-binding transcriptional activator GcvA YP_002388272.1 2992950 R 585034 CDS YP_002388273.1 218555360 7128295 complement(2994218..2994445) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2994445 ygdI 7128295 ygdI Escherichia coli IAI1 hypothetical protein YP_002388273.1 2994218 R 585034 CDS YP_002388274.1 218555361 7124887 2994637..2995842 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15148362, 9278392, 10739946, 10829016; Product type e : enzyme; cysteine sulfinate desulfinase 2995842 csdA 7124887 csdA Escherichia coli IAI1 cysteine sulfinate desulfinase YP_002388274.1 2994637 D 585034 CDS YP_002388275.1 218555362 7125921 2995842..2996285 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative Fe-S metabolism protein 2996285 ygdK 7125921 ygdK Escherichia coli IAI1 putative Fe-S metabolism protein YP_002388275.1 2995842 D 585034 CDS YP_002388276.1 218555363 7124888 complement(2996336..2997142) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2997142 ygdL 7124888 ygdL Escherichia coli IAI1 hypothetical protein YP_002388276.1 2996336 R 585034 CDS YP_002388277.1 218555364 7124889 complement(2997381..2998478) 1 NC_011741.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A 2998478 mltA 7124889 mltA Escherichia coli IAI1 murein transglycosylase A YP_002388277.1 2997381 R 585034 CDS YP_002388278.1 218555365 7128002 complement(2998852..2999043) 1 NC_011741.1 hypothetical protein 2999043 7128002 ECIAI1_2924 Escherichia coli IAI1 hypothetical protein YP_002388278.1 2998852 R 585034 CDS YP_002388279.1 218555366 7128003 complement(2999058..3000311) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12787347, 21348478; Product type e : enzyme; N-acetylmuramoyl-L-alanine amidase 3000311 amiC 7128003 amiC Escherichia coli IAI1 N-acetylmuramoyl-L-alanine amidase YP_002388279.1 2999058 R 585034 CDS YP_002388280.1 218555367 7125754 3000543..3001874 1 NC_011741.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 3001874 argA 7125754 argA Escherichia coli IAI1 N-acetylglutamate synthase YP_002388280.1 3000543 D 585034 CDS YP_002388281.1 218555368 7125786 complement(3001936..3003762) 1 NC_011741.1 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha 3003762 recD 7125786 recD Escherichia coli IAI1 exonuclease V subunit alpha YP_002388281.1 3001936 R 585034 CDS YP_002388282.1 218555369 7124948 complement(3003762..3007304) 1 NC_011741.1 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta 3007304 recB 7124948 recB Escherichia coli IAI1 exonuclease V subunit beta YP_002388282.1 3003762 R 585034 CDS YP_002388283.1 218555370 7124946 complement(3007297..3010185) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91193232, 1570301, 3308636, 3534791, 3537960, 8099278; Product type e : enzyme; protease III 3010185 ptr 7124946 ptr Escherichia coli IAI1 protease III YP_002388283.1 3007297 R 585034 CDS YP_002388284.1 218555371 7126536 complement(3010361..3013729) 1 NC_011741.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma 3013729 recC 7126536 recC Escherichia coli IAI1 exonuclease V subunit gamma YP_002388284.1 3010361 R 585034 CDS YP_002388285.1 218555372 7124947 complement(3013742..3014065) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein 3014065 ppdC 7124947 ppdC Escherichia coli IAI1 hypothetical protein YP_002388285.1 3013742 R 585034 CDS YP_002388286.1 218555373 7126128 complement(3014050..3014457) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3014457 ygdB 7126128 ygdB Escherichia coli IAI1 hypothetical protein YP_002388286.1 3014050 R 585034 CDS YP_002388287.1 218555374 7124883 complement(3014454..3015017) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein 3015017 ppdB 7124883 ppdB Escherichia coli IAI1 hypothetical protein YP_002388287.1 3014454 R 585034 CDS YP_002388288.1 218555375 7126127 complement(3015008..3015478) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein 3015478 ppdA 7126127 ppdA Escherichia coli IAI1 hypothetical protein YP_002388288.1 3015008 R 585034 CDS YP_002388289.1 218555376 7126126 complement(3015663..3016457) 1 NC_011741.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 3016457 thyA 7126126 thyA Escherichia coli IAI1 thymidylate synthase YP_002388289.1 3015663 R 585034 CDS YP_002388290.1 218555377 7126257 complement(3016464..3017339) 1 NC_011741.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 3017339 lgt 7126257 lgt Escherichia coli IAI1 prolipoprotein diacylglyceryl transferase YP_002388290.1 3016464 R 585034 CDS YP_002388291.1 218555378 7126416 complement(3017490..3019736) 1 NC_011741.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain-containing protein 3019736 ptsP 7126416 ptsP Escherichia coli IAI1 phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain-containing protein YP_002388291.1 3017490 R 585034 CDS YP_002388292.1 218555379 7126543 complement(3019749..3020279) 1 NC_011741.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 3020279 nudH 7126543 nudH Escherichia coli IAI1 dinucleoside polyphosphate hydrolase YP_002388292.1 3019749 R 585034 CDS YP_002388293.1 218555380 7125957 3020964..3021653 1 NC_011741.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 3021653 mutH 7125957 mutH Escherichia coli IAI1 DNA mismatch repair protein YP_002388293.1 3020964 D 585034 CDS YP_002388294.1 218555381 7124502 3021722..3022435 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3022435 ygdQ 7124502 ygdQ Escherichia coli IAI1 hypothetical protein YP_002388294.1 3021722 D 585034 CDS YP_002388295.1 218555382 7124890 3022573..3022791 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3022791 ygdR 7124890 ygdR Escherichia coli IAI1 hypothetical protein YP_002388295.1 3022573 D 585034 CDS YP_002388296.1 218555383 7124891 3022899..3023939 1 NC_011741.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; putative aldo-keto reductase 3023939 tas 7124891 tas Escherichia coli IAI1 putative aldo-keto reductase YP_002388296.1 3022899 D 585034 CDS YP_002388297.1 218555384 7126213 complement(3023971..3025164) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8300626; Product type pm : putative membrane component; lysophospholipid transporter LplT 3025164 ygeD 7126213 ygeD Escherichia coli IAI1 lysophospholipid transporter LplT YP_002388297.1 3023971 R 585034 CDS YP_002388298.1 218555385 7124893 complement(3025157..3027316) 1 NC_011741.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase 3027316 aas 7124893 aas Escherichia coli IAI1 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase YP_002388298.1 3025157 R 585034 CDS YP_002388299.1 218555386 7125988 3027902..3028933 1 NC_011741.1 controls transcription of galETKM; DNA-binding transcriptional regulator GalR 3028933 galR 7125988 galR Escherichia coli IAI1 DNA-binding transcriptional regulator GalR YP_002388299.1 3027902 D 585034 CDS YP_002388300.1 218555387 7128273 complement(3028940..3030202) 1 NC_011741.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase 3030202 lysA 7128273 lysA Escherichia coli IAI1 diaminopimelate decarboxylase YP_002388300.1 3028940 R 585034 CDS YP_002388301.1 218555388 7127642 3030324..3031259 1 NC_011741.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; DNA-binding transcriptional regulator LysR 3031259 lysR 7127642 lysR Escherichia coli IAI1 DNA-binding transcriptional regulator LysR YP_002388301.1 3030324 D 585034 CDS YP_002388302.1 218555389 7127645 complement(3031246..3031938) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15135544; Product type pe : putative enzyme; putative racemase 3031938 ygeA 7127645 ygeA Escherichia coli IAI1 putative racemase YP_002388302.1 3031246 R 585034 CDS YP_002388303.1 218555390 7124892 complement(3032067..3033485) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7030324, 90239116, 91154204, 2836407, 3543693, 6319708; Product type t : transporter; arabinose transporter 3033485 araE 7124892 araE Escherichia coli IAI1 arabinose transporter YP_002388303.1 3032067 R 585034 CDS YP_002388304.1 218555391 7125779 complement(3033800..3034561) 1 NC_011741.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase 3034561 kduD 7125779 kduD Escherichia coli IAI1 2-deoxy-D-gluconate 3-dehydrogenase YP_002388304.1 3033800 R 585034 CDS YP_002388305.1 218555392 7126383 complement(3034591..3035427) 1 NC_011741.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase 3035427 kduI 7126383 kduI Escherichia coli IAI1 5-keto-4-deoxyuronate isomerase YP_002388305.1 3034591 R 585034 CDS YP_002388306.1 218555393 7126384 complement(3035714..3036895) 1 NC_011741.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 3036895 yqeF 7126384 yqeF Escherichia coli IAI1 acetyl-CoA acetyltransferase YP_002388306.1 3035714 R 585034 CDS YP_002388307.1 218555394 7124348 3037150..3038379 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3038379 yqeG 7124348 yqeG Escherichia coli IAI1 putative transporter YP_002388307.1 3037150 D 585034 CDS YP_002388308.1 218555395 7124349 3038839..3039471 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3039471 yqeH 7124349 yqeH Escherichia coli IAI1 hypothetical protein YP_002388308.1 3038839 D 585034 CDS YP_002388309.1 218555396 7124350 3039805..3040614 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3040614 yqeI 7124350 yqeI Escherichia coli IAI1 putative transcriptional regulator YP_002388309.1 3039805 D 585034 CDS YP_002388310.1 218555397 7124351 3040607..3041089 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3041089 yqeJ 7124351 yqeJ Escherichia coli IAI1 hypothetical protein YP_002388310.1 3040607 D 585034 CDS YP_002388311.1 218555398 7124352 complement(3041238..3041663) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3041663 yqeK 7124352 yqeK Escherichia coli IAI1 hypothetical protein YP_002388311.1 3041238 R 585034 CDS YP_002388312.1 218555399 7128562 3041857..3042294 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3042294 ygeF 7128562 ygeF Escherichia coli IAI1 hypothetical protein YP_002388312.1 3041857 D 585034 CDS YP_002388313.1 218555400 7124894 3042572..3043063 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative chaperone 3043063 ygeG 7124894 ygeG Escherichia coli IAI1 putative chaperone YP_002388313.1 3042572 D 585034 CDS YP_002388314.1 218555401 7124895 3043398..3044774 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15150243; Product type pr : putative regulator; transcriptional regulator 3044774 ygeH 7124895 ygeH Escherichia coli IAI1 transcriptional regulator YP_002388314.1 3043398 D 585034 CDS YP_002388315.1 218555402 7124896 3044942..3045160 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3045160 ygeI 7124896 ygeI Escherichia coli IAI1 hypothetical protein YP_002388315.1 3044942 D 585034 CDS YP_002388316.1 218555403 7124897 3045243..3045719 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidoglycan-binding-like protein 3045719 7124897 ECIAI1_2966 Escherichia coli IAI1 putative peptidoglycan-binding-like protein YP_002388316.1 3045243 D 585034 CDS YP_002388317.1 218555404 7124898 complement(3047265..3047846) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12791847; hypothetical protein 3047846 7124898 ECIAI1_2970 Escherichia coli IAI1 hypothetical protein YP_002388317.1 3047265 R 585034 CDS YP_002388318.1 218555405 7128566 complement(3047862..3048596) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12791847; Product type pm : putative membrane component; putative Type III secretion system lipoprotein EprK 3048596 eprK 7128566 eprK Escherichia coli IAI1 putative Type III secretion system lipoprotein EprK YP_002388318.1 3047862 R 585034 CDS YP_002388319.1 218555406 7128567 complement(3049029..3049184) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12791847; Product type pt : putative transporter; putative Type III secretion EprI protein 3049184 eprI 7128567 eprI Escherichia coli IAI1 putative Type III secretion EprI protein YP_002388319.1 3049029 R 585034 CDS YP_002388320.1 218555407 7125081 complement(3049198..3050388) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative Type III secretion EprH protein 3050388 eprH 7125081 eprH Escherichia coli IAI1 putative Type III secretion EprH protein YP_002388320.1 3049198 R 585034 CDS YP_002388321.1 218555408 7125080 3050637..3051137 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12791847; hypothetical protein 3051137 7125080 ECIAI1_2975 Escherichia coli IAI1 hypothetical protein YP_002388321.1 3050637 D 585034 CDS YP_002388322.1 218555409 7128568 3051139..3051432 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12791847; hypothetical protein 3051432 7128568 ECIAI1_2976 Escherichia coli IAI1 hypothetical protein YP_002388322.1 3051139 D 585034 CDS YP_002388323.1 218555410 7127953 complement(3052623..3053390) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12791847; Product type pm : putative membrane component; putative Type III secretion protein EpaR 3053390 7127953 ECIAI1_2979 Escherichia coli IAI1 putative Type III secretion protein EpaR YP_002388323.1 3052623 R 585034 CDS YP_002388324.1 218555411 7127951 complement(3053662..3054327) 1 NC_011741.1 part of a type III secretory system probably involved in invasion into eukaryotic cells; surface presentation of antigens protein SpaP 3054327 spaP 7127951 spaP Escherichia coli IAI1 surface presentation of antigens protein SpaP YP_002388324.1 3053662 R 585034 CDS YP_002388325.1 218555412 7125078 complement(3055396..3057048) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3057048 7125078 ECIAI1_2983 Escherichia coli IAI1 hypothetical protein YP_002388325.1 3055396 R 585034 CDS YP_002388326.1 218555413 7128040 complement(3057392..3058147) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15150243; Product type r : regulator; Tetratricopeptide repeat transcriptional regulator 3058147 ygeR 7128040 ygeR Escherichia coli IAI1 Tetratricopeptide repeat transcriptional regulator YP_002388326.1 3057392 R 585034 CDS YP_002388327.1 218555414 7124899 complement(3058144..3058356) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 3058356 7124899 ECIAI1_2985 Escherichia coli IAI1 hypothetical protein YP_002388327.1 3058144 R 585034 CDS YP_002388328.1 218555415 7128573 3058601..3060859 1 NC_011741.1 putative molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 3060859 xdhA 7128573 xdhA Escherichia coli IAI1 xanthine dehydrogenase subunit XdhA YP_002388328.1 3058601 D 585034 CDS YP_002388329.1 218555416 7126467 3060870..3061748 1 NC_011741.1 FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 3061748 xdhB 7126467 xdhB Escherichia coli IAI1 xanthine dehydrogenase subunit XdhB YP_002388329.1 3060870 D 585034 CDS YP_002388330.1 218555417 7126468 3061745..3062224 1 NC_011741.1 iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 3062224 xdhC 7126468 xdhC Escherichia coli IAI1 xanthine dehydrogenase subunit XdhC YP_002388330.1 3061745 D 585034 CDS YP_002388331.1 218555418 7126469 complement(3062264..3064042) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3064042 ygeV 7126469 ygeV Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002388331.1 3062264 R 585034 CDS YP_002388332.1 218555419 7124900 3064518..3065708 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; aspartate/ornithine carbamoyltransferase family protein 3065708 ygeW 7124900 ygeW Escherichia coli IAI1 aspartate/ornithine carbamoyltransferase family protein YP_002388332.1 3064518 D 585034 CDS YP_002388333.1 218555420 7124901 3065766..3066962 1 NC_011741.1 catalyzes the formation of pyruvate from 2,3-diaminopropionate; diaminopropionate ammonia-lyase 3066962 ygeX 7124901 ygeX Escherichia coli IAI1 diaminopropionate ammonia-lyase YP_002388333.1 3065766 D 585034 CDS YP_002388334.1 218555421 7124902 3067020..3068231 1 NC_011741.1 Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases; peptidase 3068231 ygeY 7124902 ygeY Escherichia coli IAI1 peptidase YP_002388334.1 3067020 D 585034 CDS YP_002388335.1 218555422 7124903 3068284..3069669 1 NC_011741.1 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; phenylhydantoinase 3069669 hyuA 7124903 hyuA Escherichia coli IAI1 phenylhydantoinase YP_002388335.1 3068284 D 585034 CDS YP_002388336.1 218555423 7126035 3069717..3070649 1 NC_011741.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 3070649 yqeA 7126035 yqeA Escherichia coli IAI1 carbamate kinase YP_002388336.1 3069717 D 585034 CDS YP_002388337.1 218555424 7124345 complement(3070690..3072315) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3072315 yqeB 7124345 yqeB Escherichia coli IAI1 hypothetical protein YP_002388337.1 3070690 R 585034 CDS YP_002388338.1 218555425 7124346 complement(3072363..3073133) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3073133 yqeC 7124346 yqeC Escherichia coli IAI1 hypothetical protein YP_002388338.1 3072363 R 585034 CDS YP_002388339.1 218555426 7124347 3073236..3073814 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3073814 ygfJ 7124347 ygfJ Escherichia coli IAI1 hypothetical protein YP_002388339.1 3073236 D 585034 CDS YP_002388340.1 218555427 7124910 3074136..3077234 1 NC_011741.1 with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase; putative selenate reductase subunit YgfK 3077234 ygfK 7124910 ygfK Escherichia coli IAI1 putative selenate reductase subunit YgfK YP_002388340.1 3074136 D 585034 CDS YP_002388341.1 218555428 7124911 3077237..3078565 1 NC_011741.1 in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS; putative chlorohydrolase/aminohydrolase 3078565 ssnA 7124911 ssnA Escherichia coli IAI1 putative chlorohydrolase/aminohydrolase YP_002388341.1 3077237 D 585034 CDS YP_002388342.1 218555429 7127982 3078616..3079395 1 NC_011741.1 with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain; putative selenate reductase subunit YgfM 3079395 ygfM 7127982 ygfM Escherichia coli IAI1 putative selenate reductase subunit YgfM YP_002388342.1 3078616 D 585034 CDS YP_002388343.1 218555430 7124912 3079392..3082262 1 NC_011741.1 with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration; putative selenate reductase subunit YgfN 3082262 xdhD 7124912 xdhD Escherichia coli IAI1 putative selenate reductase subunit YgfN YP_002388343.1 3079392 D 585034 CDS YP_002388344.1 218555431 7126470 3082427..3083827 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20372655, 98213740; Product type pt : putative transporter; putative transporter 3083827 ygfO 7126470 ygfO Escherichia coli IAI1 putative transporter YP_002388344.1 3082427 D 585034 CDS YP_002388345.1 218555432 7124913 3083842..3085161 1 NC_011741.1 Catalyzes the deamination of guanine; guanine deaminase 3085161 guaD 7124913 guaD Escherichia coli IAI1 guanine deaminase YP_002388345.1 3083842 D 585034 CDS YP_002388346.1 218555433 7128479 3085197..3086564 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3086564 ygfQ 7128479 ygfQ Escherichia coli IAI1 putative transporter YP_002388346.1 3085197 D 585034 CDS YP_002388347.1 218555434 7124914 complement(3086600..3087088) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative oxidoreductase 3087088 ygfS 7124914 ygfS Escherichia coli IAI1 putative oxidoreductase YP_002388347.1 3086600 R 585034 CDS YP_002388348.1 218555435 7124915 complement(3087088..3089007) 1 NC_011741.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); putative oxidoreductase Fe-S binding subunit 3089007 ygfT 7124915 ygfT Escherichia coli IAI1 putative oxidoreductase Fe-S binding subunit YP_002388348.1 3087088 R 585034 CDS YP_002388349.1 218555436 7124916 3089443..3090891 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9098051; Product type t : transporter; transporter 3090891 ygfU 7124916 ygfU Escherichia coli IAI1 transporter YP_002388349.1 3089443 D 585034 CDS YP_002388350.1 218555437 7124917 3091141..3091689 1 NC_011741.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 3091689 idi 7124917 idi Escherichia coli IAI1 isopentenyl-diphosphate delta-isomerase YP_002388350.1 3091141 D 585034 CDS YP_002388351.1 218555438 7126045 complement(3091732..3093249) 1 NC_011741.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 3093249 lysS 7126045 lysS Escherichia coli IAI1 lysyl-tRNA synthetase YP_002388351.1 3091732 R 585034 CDS YP_002388352.1 218555439 7127646 complement(join(3093259..3094281,3094283..3094357)) 1 NC_011741.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 3094357 prfB 7127646 prfB Escherichia coli IAI1 peptide chain release factor 2 YP_002388352.1 3093259 R 585034 CDS YP_002388353.1 218555440 7126145 complement(3094448..3096181) 1 NC_011741.1 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ 3096181 recJ 7126145 recJ Escherichia coli IAI1 ssDNA exonuclease RecJ YP_002388353.1 3094448 R 585034 CDS YP_002388354.1 218555441 7124951 complement(3096187..3096897) 1 NC_011741.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC 3096897 dsbC 7124951 dsbC Escherichia coli IAI1 thiol:disulfide interchange protein DsbC YP_002388354.1 3096187 R 585034 CDS YP_002388355.1 218555442 7124624 complement(3096922..3097818) 1 NC_011741.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 3097818 xerD 7124624 xerD Escherichia coli IAI1 site-specific tyrosine recombinase XerD YP_002388355.1 3096922 R 585034 CDS YP_002388356.1 218555443 7126472 3097930..3098451 1 NC_011741.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 3098451 fldB 7126472 fldB Escherichia coli IAI1 flavodoxin FldB YP_002388356.1 3097930 D 585034 CDS YP_002388357.1 218555444 7127210 complement(3098491..3098898) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3098898 ygfX 7127210 ygfX Escherichia coli IAI1 hypothetical protein YP_002388357.1 3098491 R 585034 CDS YP_002388358.1 218555445 7124918 complement(3098879..3099145) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3099145 ygfY 7124918 ygfY Escherichia coli IAI1 hypothetical protein YP_002388358.1 3098879 R 585034 CDS YP_002388359.1 218555446 7124919 3099388..3100368 1 NC_011741.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; putative global regulator 3100368 ygfZ 7124919 ygfZ Escherichia coli IAI1 putative global regulator YP_002388359.1 3099388 D 585034 CDS YP_002388360.1 218555447 7124920 complement(3100564..3101223) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative hemolysin, inner membrane subunit 3101223 yqfA 7124920 yqfA Escherichia coli IAI1 putative hemolysin, inner membrane subunit YP_002388360.1 3100564 R 585034 CDS YP_002388361.1 218555448 7124354 complement(3101387..3101698) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3101698 yqfB 7124354 yqfB Escherichia coli IAI1 hypothetical protein YP_002388361.1 3101387 R 585034 CDS YP_002388362.1 218555449 7124355 3101737..3103176 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 88297127, 92334140; Product type e : enzyme; 6-phospho-beta-glucosidase A 3103176 bglA 7124355 bglA Escherichia coli IAI1 6-phospho-beta-glucosidase A YP_002388362.1 3101737 D 585034 CDS YP_002388363.1 218555450 7124400 complement(3103233..3103976) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3103976 ygfF 7124400 ygfF Escherichia coli IAI1 hypothetical protein YP_002388363.1 3103233 R 585034 CDS YP_002388364.1 218555451 7124906 complement(3104242..3107115) 1 NC_011741.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 3107115 gcvP 7124906 gcvP Escherichia coli IAI1 glycine dehydrogenase YP_002388364.1 3104242 R 585034 CDS YP_002388365.1 218555452 7128297 complement(3107234..3107623) 1 NC_011741.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 3107623 gcvH 7128297 gcvH Escherichia coli IAI1 glycine cleavage system protein H YP_002388365.1 3107234 R 585034 CDS YP_002388366.1 218555453 7128296 complement(3107647..3108741) 1 NC_011741.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 3108741 gcvT 7128296 gcvT Escherichia coli IAI1 glycine cleavage system aminomethyltransferase T YP_002388366.1 3107647 R 585034 CDS YP_002388367.1 218555454 7128299 complement(3109188..3110390) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1339425; Product type pe : putative enzyme; hypothetical protein 3110390 visC 7128299 visC Escherichia coli IAI1 hypothetical protein YP_002388367.1 3109188 R 585034 CDS YP_002388368.1 218555455 7125570 complement(3110413..3111591) 1 NC_011741.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase 3111591 ubiH 7125570 ubiH Escherichia coli IAI1 2-octaprenyl-6-methoxyphenyl hydroxylase YP_002388368.1 3110413 R 585034 CDS YP_002388369.1 218555456 7125516 complement(3111588..3112913) 1 NC_011741.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II 3112913 pepP 7125516 pepP Escherichia coli IAI1 proline aminopeptidase P II YP_002388369.1 3111588 R 585034 CDS YP_002388370.1 218555457 7124174 complement(3112939..3113517) 1 NC_011741.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein 3113517 ygfB 7124174 ygfB Escherichia coli IAI1 hypothetical protein YP_002388370.1 3112939 R 585034 CDS YP_002388371.1 218555458 7124905 3113685..3114014 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 412171; Product type cp : cell process; Z-ring-associated protein 3114014 zapA 7124905 zapA Escherichia coli IAI1 Z-ring-associated protein YP_002388371.1 3113685 D 585034 CDS YP_002388372.1 218555459 7128123 complement(3113964..3114290) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 3114290 7128123 ECIAI1_3030 Escherichia coli IAI1 hypothetical protein YP_002388372.1 3113964 R 585034 CDS YP_002388373.1 218555460 7127986 3114314..3114862 1 NC_011741.1 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function; putative ligase 3114862 ygfA 7127986 ygfA Escherichia coli IAI1 putative ligase YP_002388373.1 3114314 D 585034 CDS YP_002388374.1 218555461 7125500 complement(3115643..3116875) 1 NC_011741.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 3116875 serA 7125500 serA Escherichia coli IAI1 D-3-phosphoglycerate dehydrogenase YP_002388374.1 3115643 R 585034 CDS YP_002388375.1 218555462 7127908 complement(3117131..3117790) 1 NC_011741.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 3117790 rpiA 7127908 rpiA Escherichia coli IAI1 ribose-5-phosphate isomerase A YP_002388375.1 3117131 R 585034 CDS YP_002388376.1 218555463 7128617 complement(3117846..3118076) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3118076 yqfE 7128617 yqfE Escherichia coli IAI1 hypothetical protein YP_002388376.1 3117846 R 585034 CDS YP_002388377.1 218555464 7124356 3118218..3119111 1 NC_011741.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 3119111 argP 7124356 argP Escherichia coli IAI1 chromosome replication initiation inhibitor protein YP_002388377.1 3118218 D 585034 CDS YP_002388378.1 218555465 7125796 3119315..3121459 1 NC_011741.1 MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 3121459 yliK 7125796 yliK Escherichia coli IAI1 methylmalonyl-CoA mutase YP_002388378.1 3119315 D 585034 CDS YP_002388379.1 218555466 7126670 3121452..3122447 1 NC_011741.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 3122447 argK 7126670 argK Escherichia coli IAI1 arginine/ornithine transport system ATPase YP_002388379.1 3121452 D 585034 CDS YP_002388380.1 218555467 7125794 3122458..3123243 1 NC_011741.1 catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA; methylmalonyl-CoA decarboxylase 3123243 ygfG 7125794 ygfG Escherichia coli IAI1 methylmalonyl-CoA decarboxylase YP_002388380.1 3122458 D 585034 CDS YP_002388381.1 218555468 7124907 3123267..3124745 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20233703; Product type e : enzyme; propionyl-CoA:succinate-CoA transferase 3124745 ygfH 7124907 ygfH Escherichia coli IAI1 propionyl-CoA:succinate-CoA transferase YP_002388381.1 3123267 D 585034 CDS YP_002388382.1 218555469 7124908 complement(3124742..3125638) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3125638 ygfI 7124908 ygfI Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002388382.1 3124742 R 585034 CDS YP_002388383.1 218555470 7124909 complement(3125805..3126545) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3126545 yggE 7124909 yggE Escherichia coli IAI1 hypothetical protein YP_002388383.1 3125805 R 585034 CDS YP_002388384.1 218555471 7124923 complement(3126638..3127273) 1 NC_011741.1 Involved in the export of arginine; arginine exporter protein 3127273 argO 7124923 argO Escherichia coli IAI1 arginine exporter protein YP_002388384.1 3126638 R 585034 CDS YP_002388385.1 218555472 7125795 complement(3127412..3128272) 1 NC_011741.1 participates in the regulation of osmotic pressure changes within the cel; mechanosensitive channel MscS 3128272 mscS 7125795 mscS Escherichia coli IAI1 mechanosensitive channel MscS YP_002388385.1 3127412 R 585034 CDS YP_002388386.1 218555473 7124480 complement(3128630..3129709) 1 NC_011741.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 3129709 fbaA 7124480 fbaA Escherichia coli IAI1 fructose-bisphosphate aldolase YP_002388386.1 3128630 R 585034 CDS YP_002388387.1 218555474 7127068 complement(3129924..3131087) 1 NC_011741.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 3131087 pgk 7127068 pgk Escherichia coli IAI1 phosphoglycerate kinase YP_002388387.1 3129924 R 585034 CDS YP_002388388.1 218555475 7124186 complement(3131137..3132156) 1 NC_011741.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase 3132156 epd 7124186 epd Escherichia coli IAI1 erythrose 4-phosphate dehydrogenase YP_002388388.1 3131137 R 585034 CDS YP_002388389.1 218555476 7125079 3132528..3132959 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3132959 7125079 ECIAI1_3048 Escherichia coli IAI1 hypothetical protein YP_002388389.1 3132528 D 585034 CDS YP_002388390.1 218555477 7128575 3132883..3133560 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC-type transport system 3133560 7128575 ECIAI1_3049 Escherichia coli IAI1 putative ABC-type transport system YP_002388390.1 3132883 D 585034 CDS YP_002388391.1 218555478 7128576 3133561..3134268 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC-type transport system 3134268 7128576 ECIAI1_3050 Escherichia coli IAI1 putative ABC-type transport system YP_002388391.1 3133561 D 585034 CDS YP_002388392.1 218555479 7128577 3134250..3134933 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 3134933 7128577 ECIAI1_3051 Escherichia coli IAI1 putative ABC transporter ATP-binding protein YP_002388392.1 3134250 D 585034 CDS YP_002388393.1 218555480 7128578 3134894..3135604 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 3135604 7128578 ECIAI1_3052 Escherichia coli IAI1 putative ABC transporter ATP-binding protein YP_002388393.1 3134894 D 585034 CDS YP_002388394.1 218555481 7128579 complement(3135576..3136289) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative fructose transport system kinase 3136289 frcK 7128579 frcK Escherichia coli IAI1 putative fructose transport system kinase YP_002388394.1 3135576 R 585034 CDS YP_002388395.1 218555482 7124921 complement(3136286..3136795) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3136795 yggD 7124921 yggD Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002388395.1 3136286 R 585034 CDS YP_002388396.1 218555483 7124922 complement(3136817..3137782) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; fructose-1,6-bisphosphatase II-like protein 3137782 yggF 7124922 yggF Escherichia coli IAI1 fructose-1,6-bisphosphatase II-like protein YP_002388396.1 3136817 R 585034 CDS YP_002388397.1 218555484 7124932 complement(3139072..3140460) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8353127; Product type t : transporter; PTS system mannitol-specific transporter subunit IIBC 3140460 cmtA 7124932 cmtA Escherichia coli IAI1 PTS system mannitol-specific transporter subunit IIBC YP_002388397.1 3139072 R 585034 CDS YP_002388398.1 218555485 7126340 complement(3140488..3140931) 1 NC_011741.1 TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein; putative mannitol phosphotransferase subunit EIIA 3140931 cmtB 7126340 cmtB Escherichia coli IAI1 putative mannitol phosphotransferase subunit EIIA YP_002388398.1 3140488 R 585034 CDS YP_002388399.1 218555486 7126341 complement(3141245..3143236) 1 NC_011741.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 3143236 tktA 7126341 tktA Escherichia coli IAI1 transketolase YP_002388399.1 3141245 R 585034 CDS YP_002388400.1 218555487 7127451 3143514..3144272 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1310091; Product type pe : putative enzyme; putative peptidase 3144272 yggG 7127451 yggG Escherichia coli IAI1 putative peptidase YP_002388400.1 3143514 D 585034 CDS YP_002388401.1 218555488 7124925 complement(3144328..3145080) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3145080 7124925 ECIAI1_3062 Escherichia coli IAI1 hypothetical protein YP_002388401.1 3144328 R 585034 CDS YP_002388402.1 218555489 7128580 complement(3145058..3146167) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transferase 3146167 7128580 ECIAI1_3063 Escherichia coli IAI1 putative transferase YP_002388402.1 3145058 R 585034 CDS YP_002388403.1 218555490 7128581 complement(3146171..3147028) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; mannose permease IID component 3147028 7128581 ECIAI1_3064 Escherichia coli IAI1 mannose permease IID component YP_002388403.1 3146171 R 585034 CDS YP_002388404.1 218555491 7128582 complement(3147028..3147777) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system enzyme IIC 3147777 7128582 ECIAI1_3065 Escherichia coli IAI1 putative phosphotransferase system enzyme IIC YP_002388404.1 3147028 R 585034 CDS YP_002388405.1 218555492 7128583 complement(3147803..3148288) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative PTS system protein 3148288 7128583 ECIAI1_3066 Escherichia coli IAI1 putative PTS system protein YP_002388405.1 3147803 R 585034 CDS YP_002388406.1 218555493 7128584 complement(3148299..3148727) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system enzyme IIA 3148727 7128584 ECIAI1_3067 Escherichia coli IAI1 putative phosphotransferase system enzyme IIA YP_002388406.1 3148299 R 585034 CDS YP_002388407.1 218555494 7128585 complement(3148846..3151686) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative NtrC family transcriptional regulators, ATPase domain 3151686 7128585 ECIAI1_3068 Escherichia coli IAI1 putative NtrC family transcriptional regulators, ATPase domain YP_002388407.1 3148846 R 585034 CDS YP_002388408.1 218555495 7128586 complement(3151903..3152823) 1 NC_011741.1 catalyzes the formation of putrescine from agmatine; agmatinase 3152823 speB 7128586 speB Escherichia coli IAI1 agmatinase YP_002388408.1 3151903 R 585034 CDS YP_002388409.1 218555496 7127955 complement(3152959..3153690) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3153690 7127955 ECIAI1_3070 Escherichia coli IAI1 hypothetical protein YP_002388409.1 3152959 R 585034 CDS YP_002388410.1 218555497 7128587 complement(3153836..3155812) 1 NC_011741.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase 3155812 speA 7128587 speA Escherichia coli IAI1 arginine decarboxylase YP_002388410.1 3153836 R 585034 CDS YP_002388411.1 218555498 7127954 complement(3155821..3155967) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3155967 yqgB 7127954 yqgB Escherichia coli IAI1 hypothetical protein YP_002388411.1 3155821 R 585034 CDS YP_002388412.1 218555499 7124358 3156088..3156303 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3156303 yqgC 7124358 yqgC Escherichia coli IAI1 hypothetical protein YP_002388412.1 3156088 D 585034 CDS YP_002388413.1 218555500 7124359 complement(3156300..3156551) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3156551 yqgD 7124359 yqgD Escherichia coli IAI1 hypothetical protein YP_002388413.1 3156300 R 585034 CDS YP_002388414.1 218555501 7124360 3156607..3157761 1 NC_011741.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3157761 metK 7124360 metK Escherichia coli IAI1 S-adenosylmethionine synthetase YP_002388414.1 3156607 D 585034 CDS YP_002388415.1 218555502 7124251 3158197..3159591 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9182541; Product type t : transporter; D-galactose transporter 3159591 galP 7124251 galP Escherichia coli IAI1 D-galactose transporter YP_002388415.1 3158197 D 585034 CDS YP_002388416.1 218555503 7128272 3159668..3160165 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7984428, 8113204; hypothetical protein 3160165 sprT 7128272 sprT Escherichia coli IAI1 hypothetical protein YP_002388416.1 3159668 D 585034 CDS YP_002388417.1 218555504 7127965 3160260..3160967 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 72060411, 92335461, 4955462, 7867949, 8113204; Product type e : enzyme; DNA-specific endonuclease I 3160967 endA 7127965 endA Escherichia coli IAI1 DNA-specific endonuclease I YP_002388417.1 3160260 D 585034 CDS YP_002388418.1 218555505 7125066 3161047..3161778 1 NC_011741.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3161778 yggJ 7125066 yggJ Escherichia coli IAI1 16S ribosomal RNA methyltransferase RsmE YP_002388418.1 3161047 D 585034 CDS YP_002388419.1 218555506 7124927 3161791..3162741 1 NC_011741.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3162741 gshB 7124927 gshB Escherichia coli IAI1 glutathione synthetase YP_002388419.1 3161791 D 585034 CDS YP_002388420.1 218555507 7128472 3162850..3163413 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3163413 yqgE 7128472 yqgE Escherichia coli IAI1 hypothetical protein YP_002388420.1 3162850 D 585034 CDS YP_002388421.1 218555508 7124361 3163413..3163829 1 NC_011741.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3163829 yqgF 7124361 yqgF Escherichia coli IAI1 Holliday junction resolvase-like protein YP_002388421.1 3163413 D 585034 CDS YP_002388422.1 218555509 7124362 complement(3164005..3164985) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1676385; Product type t : transporter; transporter 3164985 yggR 7124362 yggR Escherichia coli IAI1 transporter YP_002388422.1 3164005 R 585034 CDS YP_002388423.1 218555510 7124933 3165003..3165707 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3165707 yggS 7124933 yggS Escherichia coli IAI1 hypothetical protein YP_002388423.1 3165003 D 585034 CDS YP_002388424.1 218555511 7124934 3165725..3166291 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3166291 yggT 7124934 yggT Escherichia coli IAI1 hypothetical protein YP_002388424.1 3165725 D 585034 CDS YP_002388425.1 218555512 7124935 3166288..3166578 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12975589; hypothetical protein 3166578 yggU 7124935 yggU Escherichia coli IAI1 hypothetical protein YP_002388425.1 3166288 D 585034 CDS YP_002388426.1 218555513 7124936 3166586..3167179 1 NC_011741.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 3167179 yggV 7124936 yggV Escherichia coli IAI1 putative deoxyribonucleotide triphosphate pyrophosphatase YP_002388426.1 3166586 D 585034 CDS YP_002388427.1 218555514 7124937 3167172..3168308 1 NC_011741.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3168308 yggW 7124937 yggW Escherichia coli IAI1 coproporphyrinogen III oxidase YP_002388427.1 3167172 D 585034 CDS YP_002388428.1 218555515 7124938 complement(3168463..3169470) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3169470 yggM 7124938 yggM Escherichia coli IAI1 hypothetical protein YP_002388428.1 3168463 R 585034 CDS YP_002388429.1 218555516 7124929 complement(3169587..3170633) 1 NC_011741.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II 3170633 ansB 7124929 ansB Escherichia coli IAI1 L-asparaginase II YP_002388429.1 3169587 R 585034 CDS YP_002388430.1 218555517 7125765 complement(3170809..3171528) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3171528 yggN 7125765 yggN Escherichia coli IAI1 hypothetical protein YP_002388430.1 3170809 R 585034 CDS YP_002388431.1 218555518 7124930 complement(3171712..3172038) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3172038 yggL 7124930 yggL Escherichia coli IAI1 hypothetical protein YP_002388431.1 3171712 R 585034 CDS YP_002388432.1 218555519 7124928 complement(3172038..3172757) 1 NC_011741.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 3172757 trmB 7124928 trmB Escherichia coli IAI1 tRNA (guanine-N(7)-)-methyltransferase YP_002388432.1 3172038 R 585034 CDS YP_002388433.1 218555520 7124926 3172918..3173970 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14730969, 20187555, 20316830, 20580749, 21438845, 90046892, 92409600, 9801309, 2001994, 2197596, 9846876; Product type e : enzyme; adenine DNA glycosylase 3173970 mutY 7124926 mutY Escherichia coli IAI1 adenine DNA glycosylase YP_002388433.1 3172918 D 585034 CDS YP_002388434.1 218555521 7124507 3173998..3174273 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594836, 10493123, 9298646, 9868784; Product type f : factor; hypothetical protein 3174273 yggX 7124507 yggX Escherichia coli IAI1 hypothetical protein YP_002388434.1 3173998 D 585034 CDS YP_002388435.1 218555522 7124939 3174338..3175417 1 NC_011741.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3175417 mltC 7124939 mltC Escherichia coli IAI1 murein transglycosylase C YP_002388435.1 3174338 D 585034 CDS YP_002388436.1 218555523 7124283 3175619..3176875 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88029453, 90323001, 3311747; Product type t : transporter; nucleoside transporter 3176875 nupG 7124283 nupG Escherichia coli IAI1 nucleoside transporter YP_002388436.1 3175619 D 585034 CDS YP_002388437.1 218555524 7125972 complement(3176925..3179060) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 87260820; Product type e : enzyme; ornithine decarboxylase 3179060 speC 7125972 speC Escherichia coli IAI1 ornithine decarboxylase YP_002388437.1 3176925 R 585034 CDS YP_002388438.1 218555525 7127956 complement(3179222..3179371) 1 NC_011741.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3179371 7127956 ECIAI1_3099 Escherichia coli IAI1 hypothetical protein YP_002388438.1 3179222 R 585034 CDS YP_002388439.1 218555526 7128588 3179458..3180165 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3180165 yqgA 7128588 yqgA Escherichia coli IAI1 hypothetical protein YP_002388439.1 3179458 D 585034 CDS YP_002388440.1 218555527 7128004 complement(3180495..3181031) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative general secretion pathway protein YghD 3181031 yghD 7128004 yghD Escherichia coli IAI1 putative general secretion pathway protein YghD YP_002388440.1 3180495 R 585034 CDS YP_002388441.1 218555528 7124942 complement(3181033..3182211) 1 NC_011741.1 similar to general secretory pathway protein L; GspL-like protein 3182211 yghE 7124942 yghE Escherichia coli IAI1 GspL-like protein YP_002388441.1 3181033 R 585034 CDS YP_002388442.1 218555529 7124943 complement(3182208..3183185) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative type II secretion protein 3183185 7124943 ECIAI1_3103 Escherichia coli IAI1 putative type II secretion protein YP_002388442.1 3182208 R 585034 CDS YP_002388443.1 218555530 7128589 complement(3183188..3183787) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3183787 7128589 ECIAI1_3104 Escherichia coli IAI1 hypothetical protein YP_002388443.1 3183188 R 585034 CDS YP_002388444.1 218555531 7128590 complement(3183784..3184155) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative type II secretion protein 3184155 7128590 ECIAI1_3105 Escherichia coli IAI1 putative type II secretion protein YP_002388444.1 3183784 R 585034 CDS YP_002388445.1 218555532 7128591 complement(3184152..3184715) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3184715 7128591 ECIAI1_3106 Escherichia coli IAI1 hypothetical protein YP_002388445.1 3184152 R 585034 CDS YP_002388446.1 218555533 7128592 complement(3184719..3185201) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative general secretion pathway protein G 3185201 7128592 ECIAI1_3107 Escherichia coli IAI1 putative general secretion pathway protein G YP_002388446.1 3184719 R 585034 CDS YP_002388447.1 218555534 7128593 complement(3185191..3186414) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; General secretion pathway protein F 3186414 epsF 7128593 epsF Escherichia coli IAI1 General secretion pathway protein F YP_002388447.1 3185191 R 585034 CDS YP_002388448.1 218555535 7125085 complement(3186414..3187907) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; general secretion pathway protein E 3187907 epsE 7125085 epsE Escherichia coli IAI1 general secretion pathway protein E YP_002388448.1 3186414 R 585034 CDS YP_002388449.1 218555536 7125084 complement(3187907..3189967) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; general secretion pathway protein D 3189967 epsD 7125084 epsD Escherichia coli IAI1 general secretion pathway protein D YP_002388449.1 3187907 R 585034 CDS YP_002388450.1 218555537 7125083 complement(3189997..3190956) 1 NC_011741.1 part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm; putative type II secretion protein GspC 3190956 yghF 7125083 yghF Escherichia coli IAI1 putative type II secretion protein GspC YP_002388450.1 3189997 R 585034 CDS YP_002388451.1 218555538 7124944 complement(3190974..3191384) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3191384 yghG 7124944 yghG Escherichia coli IAI1 hypothetical protein YP_002388451.1 3190974 R 585034 CDS YP_002388452.1 218555539 7124945 complement(3191450..3192259) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98175453; Product type e : enzyme; bifunctional prepilin leader peptidase and methylase 3192259 pppA 7124945 pppA Escherichia coli IAI1 bifunctional prepilin leader peptidase and methylase YP_002388452.1 3191450 R 585034 CDS YP_002388453.1 218555540 7126137 complement(3192399..3196976) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1644747; Product type lp : lipoprotein; inner membrane lipoprotein 3196976 yghJ 7126137 yghJ Escherichia coli IAI1 inner membrane lipoprotein YP_002388453.1 3192399 R 585034 CDS YP_002388454.1 218555541 7128607 3197124..3197309 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3197309 7128607 ECIAI1_3115 Escherichia coli IAI1 hypothetical protein YP_002388454.1 3197124 D 585034 CDS YP_002388455.1 218555542 7128594 complement(3197461..3199143) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11785976, 21178909, 11283302; Product type t : transporter; glycolate transporter 3199143 yghK 7128594 yghK Escherichia coli IAI1 glycolate transporter YP_002388455.1 3197461 R 585034 CDS YP_002388456.1 218555543 7124436 complement(3199499..3201670) 1 NC_011741.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G 3201670 glcB 7124436 glcB Escherichia coli IAI1 malate synthase G YP_002388456.1 3199499 R 585034 CDS YP_002388457.1 218555544 7128304 complement(3201692..3202096) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3202096 glcG 7128304 glcG Escherichia coli IAI1 hypothetical protein YP_002388457.1 3201692 R 585034 CDS YP_002388458.1 218555545 7128309 complement(3202101..3203324) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type c : carrier; glycolate oxidase iron-sulfur subunit 3203324 glcF 7128309 glcF Escherichia coli IAI1 glycolate oxidase iron-sulfur subunit YP_002388458.1 3202101 R 585034 CDS YP_002388459.1 218555546 7128308 complement(3203335..3204387) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type e : enzyme; glycolate oxidase FAD binding subunit 3204387 glcE 7128308 glcE Escherichia coli IAI1 glycolate oxidase FAD binding subunit YP_002388459.1 3203335 R 585034 CDS YP_002388460.1 218555547 7128307 complement(3204387..3205886) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type e : enzyme; glycolate oxidase subunit GlcD 3205886 glcD 7128307 glcD Escherichia coli IAI1 glycolate oxidase subunit GlcD YP_002388460.1 3204387 R 585034 CDS YP_002388461.1 218555548 7128306 3206137..3206901 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 9880556, 8606183; Product type r : regulator; DNA-binding transcriptional regulator GlcC 3206901 glcC 7128306 glcC Escherichia coli IAI1 DNA-binding transcriptional regulator GlcC YP_002388461.1 3206137 D 585034 CDS YP_002388462.1 218555549 7128305 complement(3206908..3208050) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3208050 yghO 7128305 yghO Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002388462.1 3206908 R 585034 CDS YP_002388463.1 218555550 7128595 3209929..3211053 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative epimerase 3211053 7128595 ECIAI1_3125 Escherichia coli IAI1 putative epimerase YP_002388463.1 3209929 D 585034 CDS YP_002388464.1 218555551 7128596 3211085..3211333 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3211333 7128596 ECIAI1_3126 Escherichia coli IAI1 hypothetical protein YP_002388464.1 3211085 D 585034 CDS YP_002388465.1 218555552 7128597 3211333..3212505 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 8-amino-7-oxononanoate synthase 3212505 7128597 ECIAI1_3127 Escherichia coli IAI1 putative 8-amino-7-oxononanoate synthase YP_002388465.1 3211333 D 585034 CDS YP_002388466.1 218555553 7128598 complement(3212541..3213701) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3213701 7128598 ECIAI1_3128 Escherichia coli IAI1 hypothetical protein YP_002388466.1 3212541 R 585034 CDS YP_002388467.1 218555554 7128599 complement(3213617..3214687) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3214687 7128599 ECIAI1_3129 Escherichia coli IAI1 hypothetical protein YP_002388467.1 3213617 R 585034 CDS YP_002388468.1 218555555 7128600 complement(3214718..3215281) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3215281 7128600 ECIAI1_3130 Escherichia coli IAI1 putative transcriptional regulator YP_002388468.1 3214718 R 585034 CDS YP_002388469.1 218555556 7128601 complement(3215290..3216114) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3216114 7128601 ECIAI1_3131 Escherichia coli IAI1 hypothetical protein YP_002388469.1 3215290 R 585034 CDS YP_002388470.1 218555557 7128602 complement(3216114..3217463) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 3217463 7128602 ECIAI1_3132 Escherichia coli IAI1 hypothetical protein YP_002388470.1 3216114 R 585034 CDS YP_002388471.1 218555558 7128603 complement(3217509..3218267) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3218267 yghR 7128603 yghR Escherichia coli IAI1 hypothetical protein YP_002388471.1 3217509 R 585034 CDS YP_002388472.1 218555559 7128705 complement(3218299..3219012) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3219012 yghS 7128705 yghS Escherichia coli IAI1 hypothetical protein YP_002388472.1 3218299 R 585034 CDS YP_002388473.1 218555560 7128706 3219186..3219878 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3219878 yghT 7128706 yghT Escherichia coli IAI1 hypothetical protein YP_002388473.1 3219186 D 585034 CDS YP_002388474.1 218555561 7128707 complement(3219927..3221426) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21336523, 21382172, 7775463; Product type t : transporter; phosphate transporter 3221426 pitB 7128707 pitB Escherichia coli IAI1 phosphate transporter YP_002388474.1 3219927 R 585034 CDS YP_002388475.1 218555562 7124378 complement(3221718..3223577) 1 NC_011741.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase 3223577 gss 7124378 gss Escherichia coli IAI1 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase YP_002388475.1 3221718 R 585034 CDS YP_002388476.1 218555563 7128474 3223782..3224648 1 NC_011741.1 YghU; B2989; one of eight putative glutathione transferase proteins from E. coli; putative glutathione S-transferase YghU 3224648 yghU 7128474 yghU Escherichia coli IAI1 putative glutathione S-transferase YghU YP_002388476.1 3223782 D 585034 CDS YP_002388477.1 218555564 7128708 complement(3224771..3225019) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 94292472, 8021226; Product type pf : putative factor; hydrogenase 2 accessory protein HypG 3225019 hybG 7128708 hybG Escherichia coli IAI1 hydrogenase 2 accessory protein HypG YP_002388477.1 3224771 R 585034 CDS YP_002388478.1 218555565 7125338 complement(3225032..3225373) 1 NC_011741.1 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF 3225373 hybF 7125338 hybF Escherichia coli IAI1 hydrogenase nickel incorporation protein HybF YP_002388478.1 3225032 R 585034 CDS YP_002388479.1 218555566 7125337 complement(3225366..3225854) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94292472, 8021226; Product type f : factor; hydrogenase 2-specific chaperone 3225854 hybE 7125337 hybE Escherichia coli IAI1 hydrogenase 2-specific chaperone YP_002388479.1 3225366 R 585034 CDS YP_002388480.1 218555567 7125336 complement(3225847..3226341) 1 NC_011741.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase 3226341 hybD 7125336 hybD Escherichia coli IAI1 hydrogenase 2 maturation endopeptidase YP_002388480.1 3225847 R 585034 CDS YP_002388481.1 218555568 7125335 complement(3226341..3228044) 1 NC_011741.1 involved in hydrogen uptake; hydrogenase 2 large subunit 3228044 hybC 7125335 hybC Escherichia coli IAI1 hydrogenase 2 large subunit YP_002388481.1 3226341 R 585034 CDS YP_002388482.1 218555569 7125334 complement(3228041..3229219) 1 NC_011741.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; putative hydrogenase 2 b cytochrome subunit 3229219 hybB 7125334 hybB Escherichia coli IAI1 putative hydrogenase 2 b cytochrome subunit YP_002388482.1 3228041 R 585034 CDS YP_002388483.1 218555570 7125333 complement(3229209..3230195) 1 NC_011741.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA 3230195 hybA 7125333 hybA Escherichia coli IAI1 hydrogenase 2 protein HybA YP_002388483.1 3229209 R 585034 CDS YP_002388484.1 218555571 7125332 complement(3230198..3231316) 1 NC_011741.1 involved in hydrogen uptake; hydrogenase 2 small subunit 3231316 hybO 7125332 hybO Escherichia coli IAI1 hydrogenase 2 small subunit YP_002388484.1 3230198 R 585034 CDS YP_002388485.1 218555572 7125339 complement(3231323..3231508) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 3231508 7125339 ECIAI1_3147 Escherichia coli IAI1 hypothetical protein YP_002388485.1 3231323 R 585034 CDS YP_002388486.1 218555573 7128604 complement(3231505..3231792) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3231792 yghW 7128604 yghW Escherichia coli IAI1 hypothetical protein YP_002388486.1 3231505 R 585034 CDS YP_002388487.1 218555574 7128709 complement(3231911..3232843) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3232843 7128709 ECIAI1_3149 Escherichia coli IAI1 hypothetical protein YP_002388487.1 3231911 R 585034 CDS YP_002388488.1 218555575 7128605 3232955..3233995 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12583903; Product type e : enzyme; aldo-keto reductase 3233995 yghZ 7128605 yghZ Escherichia coli IAI1 aldo-keto reductase YP_002388488.1 3232955 D 585034 CDS YP_002388489.1 218555576 7128710 complement(3234035..3234529) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3234529 yqhA 7128710 yqhA Escherichia coli IAI1 hypothetical protein YP_002388489.1 3234035 R 585034 CDS YP_002388490.1 218555577 7124363 3234720..3235604 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; oxidoreductase 3235604 yghA 7124363 yghA Escherichia coli IAI1 oxidoreductase YP_002388490.1 3234720 D 585034 CDS YP_002388491.1 218555578 7124940 complement(3235876..3236301) 1 NC_011741.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD 3236301 exbD 7124940 exbD Escherichia coli IAI1 biopolymer transport protein ExbD YP_002388491.1 3235876 R 585034 CDS YP_002388492.1 218555579 7127047 complement(3236308..3237042) 1 NC_011741.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB 3237042 exbB 7127047 exbB Escherichia coli IAI1 biopolymer transport protein ExbB YP_002388492.1 3236308 R 585034 CDS YP_002388493.1 218555580 7127046 complement(3237035..3237190) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 3237190 7127046 ECIAI1_3155 Escherichia coli IAI1 hypothetical protein YP_002388493.1 3237035 R 585034 CDS YP_002388494.1 218555581 7128606 3237294..3238481 1 NC_011741.1 catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3238481 metC 7128606 metC Escherichia coli IAI1 cystathionine beta-lyase YP_002388494.1 3237294 D 585034 CDS YP_002388495.1 218555582 7124244 3238621..3239280 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3239280 yghB 7124244 yghB Escherichia coli IAI1 hypothetical protein YP_002388495.1 3238621 D 585034 CDS YP_002388496.1 218555583 7124941 complement(3239320..3240276) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3240276 yqhC 7124941 yqhC Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002388496.1 3239320 R 585034 CDS YP_002388497.1 218555584 7124364 3240413..3241576 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15327949; Product type e : enzyme; alcohol dehydrogenase 3241576 yqhD 7124364 yqhD Escherichia coli IAI1 alcohol dehydrogenase YP_002388497.1 3240413 D 585034 CDS YP_002388498.1 218555585 7124365 3241681..3242508 1 NC_011741.1 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3242508 dkgA 7124365 dkgA Escherichia coli IAI1 2,5-diketo-D-gluconate reductase A YP_002388498.1 3241681 D 585034 CDS YP_002388499.1 218555586 7124596 3242708..3243634 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3243634 yqhG 7124596 yqhG Escherichia coli IAI1 hypothetical protein YP_002388499.1 3242708 D 585034 CDS YP_002388500.1 218555587 7124366 3243685..3243942 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative outer membrane lipoprotein 3243942 yqhH 7124366 yqhH Escherichia coli IAI1 putative outer membrane lipoprotein YP_002388500.1 3243685 D 585034 CDS YP_002388501.1 218555588 7124367 complement(3243985..3246204) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3246204 ygiQ 7124367 ygiQ Escherichia coli IAI1 hypothetical protein YP_002388501.1 3243985 R 585034 CDS YP_002388502.1 218555589 7128718 complement(3246315..3247727) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88314889, 1557036, 9298646; Product type r : regulator; repressor protein for FtsI 3247727 sufI 7128718 sufI Escherichia coli IAI1 repressor protein for FtsI YP_002388502.1 3246315 R 585034 CDS YP_002388503.1 218555590 7126197 complement(3247802..3248539) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92212294, 1557036; Product type e : enzyme; 1-acyl-sn-glycerol-3-phosphate acyltransferase 3248539 plsC 7126197 plsC Escherichia coli IAI1 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_002388503.1 3247802 R 585034 CDS YP_002388504.1 218555591 7126100 complement(3248587..3248742) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3248742 7126100 ECIAI1_3167 Escherichia coli IAI1 hypothetical protein YP_002388504.1 3248587 R 585034 CDS YP_002388505.1 218555592 7126179 complement(3248772..3251030) 1 NC_011741.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 3251030 parC 7126179 parC Escherichia coli IAI1 DNA topoisomerase IV subunit A YP_002388505.1 3248772 R 585034 CDS YP_002388506.1 218555593 7124155 complement(3251576..3252058) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3252058 ygiV 7124155 ygiV Escherichia coli IAI1 putative transcriptional regulator YP_002388506.1 3251576 R 585034 CDS YP_002388507.1 218555594 7128719 complement(3252111..3252503) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9298646; hypothetical protein 3252503 ygiW 7128719 ygiW Escherichia coli IAI1 hypothetical protein YP_002388507.1 3252111 R 585034 CDS YP_002388508.1 218555595 7128720 3252655..3253314 1 NC_011741.1 response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3253314 qseB 7128720 qseB Escherichia coli IAI1 DNA-binding transcriptional regulator QseB YP_002388508.1 3252655 D 585034 CDS YP_002388509.1 218555596 7126580 3253311..3254660 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21927389; Product type r : regulator; sensor protein QseC 3254660 qseC 7126580 qseC Escherichia coli IAI1 sensor protein QseC YP_002388509.1 3253311 D 585034 CDS YP_002388510.1 218555597 7126581 complement(3254706..3255038) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3255038 ygiZ 7126581 ygiZ Escherichia coli IAI1 hypothetical protein YP_002388510.1 3254706 R 585034 CDS YP_002388511.1 218555598 7128721 3255357..3255938 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96004656, 96217538; Product type c : carrier; NADPH quinone reductase 3255938 mdaB 7128721 mdaB Escherichia coli IAI1 NADPH quinone reductase YP_002388511.1 3255357 D 585034 CDS YP_002388512.1 218555599 7127679 3255969..3256283 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10493123, 9298646, 9600841, 9868784; Product type e : enzyme; quinol monooxygenase 3256283 ygiN 7127679 ygiN Escherichia coli IAI1 quinol monooxygenase YP_002388512.1 3255969 D 585034 CDS YP_002388513.1 218555600 7128716 complement(3256331..3258223) 1 NC_011741.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 3258223 parE 7128716 parE Escherichia coli IAI1 DNA topoisomerase IV subunit B YP_002388513.1 3256331 R 585034 CDS YP_002388514.1 218555601 7124156 complement(3258252..3258833) 1 NC_011741.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YqiA 3258833 yqiA 7124156 yqiA Escherichia coli IAI1 esterase YqiA YP_002388514.1 3258252 R 585034 CDS YP_002388515.1 218555602 7124368 complement(3258833..3259660) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96411758; Product type e : enzyme; cyclic 3',5'-adenosine monophosphate phosphodiesterase 3259660 cpdA 7124368 cpdA Escherichia coli IAI1 cyclic 3',5'-adenosine monophosphate phosphodiesterase YP_002388515.1 3258833 R 585034 CDS YP_002388516.1 218555603 7126354 complement(3259685..3260107) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3260107 yqiB 7126354 yqiB Escherichia coli IAI1 hypothetical protein YP_002388516.1 3259685 R 585034 CDS YP_002388517.1 218555604 7124369 complement(3260108..3260737) 1 NC_011741.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase NudF 3260737 nudF 7124369 nudF Escherichia coli IAI1 ADP-ribose pyrophosphatase NudF YP_002388517.1 3260108 R 585034 CDS YP_002388518.1 218555605 7125955 3260942..3262423 1 NC_011741.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3262423 tolC 7125955 tolC Escherichia coli IAI1 outer membrane channel protein YP_002388518.1 3260942 D 585034 CDS YP_002388519.1 218555606 7127460 3262667..3263242 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3263242 ygiB 7127460 ygiB Escherichia coli IAI1 hypothetical protein YP_002388519.1 3262667 D 585034 CDS YP_002388520.1 218555607 7128711 3263248..3264408 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3264408 ygiC 7128711 ygiC Escherichia coli IAI1 hypothetical protein YP_002388520.1 3263248 D 585034 CDS YP_002388521.1 218555608 7128712 complement(3264446..3265261) 1 NC_011741.1 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein 3265261 zupT 7128712 zupT Escherichia coli IAI1 hypothetical protein YP_002388521.1 3264446 R 585034 CDS YP_002388522.1 218555609 7128134 3265377..3266150 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11790762, 1314093; Product type t : transporter; zinc transporter ZupT 3266150 ygiE 7128134 ygiE Escherichia coli IAI1 zinc transporter ZupT YP_002388522.1 3265377 D 585034 CDS YP_002388523.1 218555610 7128713 complement(3266208..3266402) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3266402 7128713 ECIAI1_3188 Escherichia coli IAI1 hypothetical protein YP_002388523.1 3266208 R 585034 CDS YP_002388524.1 218555611 7125591 complement(3266639..3267292) 1 NC_011741.1 DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase 3267292 ribB 7125591 ribB Escherichia coli IAI1 3,4-dihydroxy-2-butanone 4-phosphate synthase YP_002388524.1 3266639 R 585034 CDS YP_002388525.1 218555612 7124993 complement(3267419..3267493) 1 NC_011741.1 hypothetical protein 3267493 7124993 ECIAI1_3190 Escherichia coli IAI1 hypothetical protein YP_002388525.1 3267419 R 585034 CDS YP_002388526.1 218555613 7125592 3267666..3267956 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3267956 yqiC 7125592 yqiC Escherichia coli IAI1 hypothetical protein YP_002388526.1 3267666 D 585034 CDS YP_002388527.1 218555614 7124370 3268239..3268790 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial protein 3268790 ygiL 7124370 ygiL Escherichia coli IAI1 putative fimbrial protein YP_002388527.1 3268239 D 585034 CDS YP_002388528.1 218555615 7128715 3268841..3271354 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; outer membrane usher protein 3271354 yqiG 7128715 yqiG Escherichia coli IAI1 outer membrane usher protein YP_002388528.1 3268841 D 585034 CDS YP_002388529.1 218555616 7124371 3271370..3272119 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; periplasmic pilin chaperone 3272119 yqiH 7124371 yqiH Escherichia coli IAI1 periplasmic pilin chaperone YP_002388529.1 3271370 D 585034 CDS YP_002388530.1 218555617 7124372 3272121..3273185 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3273185 yqiI 7124372 yqiI Escherichia coli IAI1 hypothetical protein YP_002388530.1 3272121 D 585034 CDS YP_002388531.1 218555618 7124373 complement(3273228..3273428) 1 NC_011741.1 Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS 3273428 glgS 7124373 glgS Escherichia coli IAI1 glycogen synthesis protein GlgS YP_002388531.1 3273228 R 585034 CDS YP_002388532.1 218555619 7128315 3273697..3274326 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3274326 yqiJ 7128315 yqiJ Escherichia coli IAI1 hypothetical protein YP_002388532.1 3273697 D 585034 CDS YP_002388533.1 218555620 7124374 3274353..3276014 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3276014 yqiK 7124374 yqiK Escherichia coli IAI1 hypothetical protein YP_002388533.1 3274353 D 585034 CDS YP_002388534.1 218555621 7125501 complement(3276808..3278241) 1 NC_011741.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 3278241 rfaE 7125501 rfaE Escherichia coli IAI1 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase YP_002388534.1 3276808 R 585034 CDS YP_002388535.1 218555622 7124962 complement(3278289..3281129) 1 NC_011741.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 3281129 glnE 7124962 glnE Escherichia coli IAI1 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase YP_002388535.1 3278289 R 585034 CDS YP_002388536.1 218555623 7128324 complement(3281152..3282453) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8412694; Product type pe : putative enzyme; putative adenylate cyclase 3282453 ygiF 7128324 ygiF Escherichia coli IAI1 putative adenylate cyclase YP_002388536.1 3281152 R 585034 CDS YP_002388537.1 218555624 7128714 complement(3282470..3282676) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 3282676 7128714 ECIAI1_3202 Escherichia coli IAI1 hypothetical protein YP_002388537.1 3282470 R 585034 CDS YP_002388538.1 218555625 7125593 3282695..3283315 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11274153; Product type pr : putative regulator; putative signal transduction protein 3283315 htrG 7125593 htrG Escherichia coli IAI1 putative signal transduction protein YP_002388538.1 3282695 D 585034 CDS YP_002388539.1 218555626 7125323 3283379..3284617 1 NC_011741.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3284617 cca 7125323 cca Escherichia coli IAI1 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase YP_002388539.1 3283379 D 585034 CDS YP_002388540.1 218555627 7124455 complement(3284780..3285601) 1 NC_011741.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 3285601 bacA 7124455 bacA Escherichia coli IAI1 undecaprenyl pyrophosphate phosphatase YP_002388540.1 3284780 R 585034 CDS YP_002388541.1 218555628 7126287 complement(3285691..3286059) 1 NC_011741.1 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase 3286059 folB 7126287 folB Escherichia coli IAI1 bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase YP_002388541.1 3285691 R 585034 CDS YP_002388542.1 218555629 7127260 3286164..3286781 1 NC_011741.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY 3286781 plsY 7127260 plsY Escherichia coli IAI1 putative glycerol-3-phosphate acyltransferase PlsY YP_002388542.1 3286164 D 585034 CDS YP_002388543.1 218555630 7126102 complement(3286794..3287726) 1 NC_011741.1 activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol; transcriptional activator TtdR 3287726 ygiP 7126102 ygiP Escherichia coli IAI1 transcriptional activator TtdR YP_002388543.1 3286794 R 585034 CDS YP_002388544.1 218555631 7128717 3287933..3288844 1 NC_011741.1 Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 3288844 ttdA 7128717 ttdA Escherichia coli IAI1 tartrate dehydratase subunit alpha YP_002388544.1 3287933 D 585034 CDS YP_002388545.1 218555632 7127513 3288841..3289446 1 NC_011741.1 Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 3289446 ttdB 7127513 ttdB Escherichia coli IAI1 L(+)-tartrate dehydratase subunit beta YP_002388545.1 3288841 D 585034 CDS YP_002388546.1 218555633 7127514 3289494..3290957 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative tartrate:succinate antiporter 3290957 ygjE 7127514 ygjE Escherichia coli IAI1 putative tartrate:succinate antiporter YP_002388546.1 3289494 D 585034 CDS YP_002388547.1 218555634 7128722 complement(3291000..3292013) 1 NC_011741.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 3292013 gcp 7128722 gcp Escherichia coli IAI1 putative DNA-binding/iron metalloprotein/AP endonuclease YP_002388547.1 3291000 R 585034 CDS YP_002388548.1 218555635 7128293 3292250..3292465 1 NC_011741.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3292465 rpsU 7128293 rpsU Escherichia coli IAI1 30S ribosomal protein S21 YP_002388548.1 3292250 D 585034 CDS YP_002388549.1 218555636 7128427 3292576..3294321 1 NC_011741.1 synthesizes RNA primers at the replication forks; DNA primase 3294321 dnaG 7128427 dnaG Escherichia coli IAI1 DNA primase YP_002388549.1 3292576 D 585034 CDS YP_002388550.1 218555637 7124608 3294516..3296357 1 NC_011741.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3296357 rpoD 7124608 rpoD Escherichia coli IAI1 RNA polymerase sigma factor RpoD YP_002388550.1 3294516 D 585034 CDS YP_002388551.1 218555638 7128399 complement(3296435..3296941) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20412902, 99453007, 6269063, 7567469, 8878487, 9489705; Product type e : enzyme; G/U mismatch-specific DNA glycosylase 3296941 ygjF 7128399 ygjF Escherichia coli IAI1 G/U mismatch-specific DNA glycosylase YP_002388551.1 3296435 R 585034 CDS YP_002388552.1 218555639 7128006 complement(3297195..3297959) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative siderophore interacting protein 3297959 yqjH 7128006 yqjH Escherichia coli IAI1 putative siderophore interacting protein YP_002388552.1 3297195 R 585034 CDS YP_002388553.1 218555640 7128070 3298236..3298859 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3298859 yqjI 7128070 yqjI Escherichia coli IAI1 putative transcriptional regulator YP_002388553.1 3298236 D 585034 CDS YP_002388554.1 218555641 7128071 complement(3299013..3300533) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20015410, 9380671, 9643537, 9190831; Product type r : regulator; signal transducer for aerotaxis sensory protein 3300533 aer 7128071 aer Escherichia coli IAI1 signal transducer for aerotaxis sensory protein YP_002388554.1 3299013 R 585034 CDS YP_002388555.1 218555642 7125725 3300924..3302330 1 NC_011741.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 3302330 ygjG 7125725 ygjG Escherichia coli IAI1 putrescine--2-oxoglutarate aminotransferase YP_002388555.1 3300924 D 585034 CDS YP_002388556.1 218555643 7128724 complement(3302372..3302704) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11101501; hypothetical protein 3302704 ygjH 7128724 ygjH Escherichia coli IAI1 hypothetical protein YP_002388556.1 3302372 R 585034 CDS YP_002388557.1 218555644 7128725 3302923..3303906 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89128452, 2515108, 3939708; Product type r : regulator; DNA-binding transcriptional repressor EbgR 3303906 ebgR 7128725 ebgR Escherichia coli IAI1 DNA-binding transcriptional repressor EbgR YP_002388557.1 3302923 D 585034 CDS YP_002388558.1 218555645 7125042 3304090..3307182 1 NC_011741.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 3307182 ebgA 7125042 ebgA Escherichia coli IAI1 cryptic beta-D-galactosidase subunit alpha YP_002388558.1 3304090 D 585034 CDS YP_002388559.1 218555646 7125040 3307179..3307628 1 NC_011741.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 3307628 ebgC 7125040 ebgC Escherichia coli IAI1 cryptic beta-D-galactosidase subunit beta YP_002388559.1 3307179 D 585034 CDS YP_002388560.1 218555647 7125041 3307691..3309124 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3309124 ygjI 7125041 ygjI Escherichia coli IAI1 putative transporter YP_002388560.1 3307691 D 585034 CDS YP_002388561.1 218555648 7128726 3309258..3310328 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3310328 ygjJ 7128726 ygjJ Escherichia coli IAI1 hypothetical protein YP_002388561.1 3309258 D 585034 CDS YP_002388562.1 218555649 7128727 3310345..3312696 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15213393; Product type pe : putative enzyme; putative glycosyl hydrolase 3312696 ygjK 7128727 ygjK Escherichia coli IAI1 putative glycosyl hydrolase YP_002388562.1 3310345 D 585034 CDS YP_002388563.1 218555650 7128728 3313022..3315040 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12840019, 89380266; Product type e : enzyme; 2,4-dienoyl-CoA reductase, NADH and FMN-linked 3315040 fadH 7128728 fadH Escherichia coli IAI1 2,4-dienoyl-CoA reductase, NADH and FMN-linked YP_002388563.1 3313022 D 585034 CDS YP_002388564.1 218555651 7127065 complement(3315085..3315501) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3315501 ygjM 7127065 ygjM Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002388564.1 3315085 R 585034 CDS YP_002388565.1 218555652 7128729 complement(3315771..3316907) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase small domain 3316907 ygjO 7128729 ygjO Escherichia coli IAI1 putative methyltransferase small domain YP_002388565.1 3315771 R 585034 CDS YP_002388566.1 218555653 7128730 3316992..3317495 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal dependent hydrolase 3317495 ygjP 7128730 ygjP Escherichia coli IAI1 putative metal dependent hydrolase YP_002388566.1 3316992 D 585034 CDS YP_002388567.1 218555654 7128731 3317572..3318255 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative thioredoxin-like 3318255 ygjQ 7128731 ygjQ Escherichia coli IAI1 putative thioredoxin-like YP_002388567.1 3317572 D 585034 CDS YP_002388568.1 218555655 7128732 3318316..3319320 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P)-binding dehydrogenase 3319320 ygjR 7128732 ygjR Escherichia coli IAI1 putative NAD(P)-binding dehydrogenase YP_002388568.1 3318316 D 585034 CDS YP_002388569.1 218555656 7127969 3319603..3320568 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12107143, 2108134; Product type pm : putative membrane component; hypothetical protein 3320568 alx 7127969 alx Escherichia coli IAI1 hypothetical protein YP_002388569.1 3319603 D 585034 CDS YP_002388570.1 218555657 7125751 3320967..3322211 1 NC_011741.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3322211 sstT 7125751 sstT Escherichia coli IAI1 serine/threonine transporter SstT YP_002388570.1 3320967 D 585034 CDS YP_002388571.1 218555658 7124863 complement(3322216..3322767) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3322767 ygjV 7124863 ygjV Escherichia coli IAI1 hypothetical protein YP_002388571.1 3322216 R 585034 CDS YP_002388572.1 218555659 7128734 complement(3322850..3324337) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4570160, 83114543, 3038546; Product type e : enzyme; altronate hydrolase 3324337 uxaA 7128734 uxaA Escherichia coli IAI1 altronate hydrolase YP_002388572.1 3322850 R 585034 CDS YP_002388573.1 218555660 7125560 complement(3324352..3325764) 1 NC_011741.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase 3325764 uxaC 7125560 uxaC Escherichia coli IAI1 glucuronate isomerase YP_002388573.1 3324352 R 585034 CDS YP_002388574.1 218555661 7125562 3326127..3327545 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83218546, 98190790; Product type t : transporter; hexuronate transporter 3327545 exuT 7125562 exuT Escherichia coli IAI1 hexuronate transporter YP_002388574.1 3326127 D 585034 CDS YP_002388575.1 218555662 7127051 complement(3327633..3328721) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3328721 7127051 ECIAI1_3240 Escherichia coli IAI1 hypothetical protein YP_002388575.1 3327633 R 585034 CDS YP_002388576.1 218555663 7125594 complement(3328718..3331420) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3331420 7125594 ECIAI1_3241 Escherichia coli IAI1 hypothetical protein YP_002388576.1 3328718 R 585034 CDS YP_002388577.1 218555664 7125595 complement(3331494..3331994) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative adhesin major subunit pilin 3331994 7125595 ECIAI1_3242 Escherichia coli IAI1 putative adhesin major subunit pilin YP_002388577.1 3331494 R 585034 CDS YP_002388578.1 218555665 7125596 complement(3332024..3332740) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial protein 3332740 7125596 ECIAI1_3243 Escherichia coli IAI1 putative fimbrial protein YP_002388578.1 3332024 R 585034 CDS YP_002388579.1 218555666 7125597 3333036..3333812 1 NC_011741.1 regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 3333812 exuR 7125597 exuR Escherichia coli IAI1 DNA-binding transcriptional repressor ExuR YP_002388579.1 3333036 D 585034 CDS YP_002388580.1 218555667 7127050 3334157..3334819 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3334819 yqjA 7127050 yqjA Escherichia coli IAI1 hypothetical protein YP_002388580.1 3334157 D 585034 CDS YP_002388581.1 218555668 7124376 3334823..3335206 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3335206 yqjB 7124376 yqjB Escherichia coli IAI1 hypothetical protein YP_002388581.1 3334823 D 585034 CDS YP_002388582.1 218555669 7124377 3335353..3335721 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3335721 yqjC 7124377 yqjC Escherichia coli IAI1 hypothetical protein YP_002388582.1 3335353 D 585034 CDS YP_002388583.1 218555670 7127906 3335759..3336064 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3336064 yqjD 7127906 yqjD Escherichia coli IAI1 hypothetical protein YP_002388583.1 3335759 D 585034 CDS YP_002388584.1 218555671 7128066 3336067..3336471 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3336471 yqjE 7128066 yqjE Escherichia coli IAI1 hypothetical protein YP_002388584.1 3336067 D 585034 CDS YP_002388585.1 218555672 7128067 3336461..3336760 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3336760 yqjK 7128067 yqjK Escherichia coli IAI1 hypothetical protein YP_002388585.1 3336461 D 585034 CDS YP_002388586.1 218555673 7128072 3336946..3337338 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative quinol oxidase subunit 3337338 yqjF 7128072 yqjF Escherichia coli IAI1 putative quinol oxidase subunit YP_002388586.1 3336946 D 585034 CDS YP_002388587.1 218555674 7128068 3337408..3338394 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8478329; Product type e : enzyme; S-transferase 3338394 yqjG 7128068 yqjG Escherichia coli IAI1 S-transferase YP_002388587.1 3337408 D 585034 CDS YP_002388588.1 218555675 7128069 3338687..3339052 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3339052 yhaH 7128069 yhaH Escherichia coli IAI1 hypothetical protein YP_002388588.1 3338687 D 585034 CDS YP_002388589.1 218555676 7128737 3339294..3339650 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3339650 yhaI 7128737 yhaI Escherichia coli IAI1 hypothetical protein YP_002388589.1 3339294 D 585034 CDS YP_002388590.1 218555677 7128738 complement(3339701..3340597) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3340597 yhaJ 7128738 yhaJ Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002388590.1 3339701 R 585034 CDS YP_002388591.1 218555678 7128739 3340702..3341403 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative pirin-related protein 3341403 yhaK 7128739 yhaK Escherichia coli IAI1 putative pirin-related protein YP_002388591.1 3340702 D 585034 CDS YP_002388592.1 218555679 7128740 3341426..3341590 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3341590 yhaL 7128740 yhaL Escherichia coli IAI1 hypothetical protein YP_002388592.1 3341426 D 585034 CDS YP_002388593.1 218555680 7128741 complement(3341580..3341741) 1 NC_011741.1 hypothetical protein 3341741 7128741 ECIAI1_3258 Escherichia coli IAI1 hypothetical protein YP_002388593.1 3341580 R 585034 CDS YP_002388594.1 218555681 7125598 complement(3341802..3343112) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3343112 yhaM 7125598 yhaM Escherichia coli IAI1 hypothetical protein YP_002388594.1 3341802 R 585034 CDS YP_002388595.1 218555682 7128742 complement(3343140..3344408) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3344408 yhaO 7128742 yhaO Escherichia coli IAI1 putative transporter YP_002388595.1 3343140 R 585034 CDS YP_002388596.1 218555683 7128743 complement(3344746..3346110) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98143432, 9484901; Product type e : enzyme; L-serine dehydratase 3 3346110 tdcG 7128743 tdcG Escherichia coli IAI1 L-serine dehydratase 3 YP_002388596.1 3344746 R 585034 CDS YP_002388597.1 218555684 7126230 complement(3346182..3346571) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12777779, 9484901; Product type e : enzyme; hypothetical protein 3346571 tdcF 7126230 tdcF Escherichia coli IAI1 hypothetical protein YP_002388597.1 3346182 R 585034 CDS YP_002388598.1 218555685 7126229 complement(3346585..3348879) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98143432, 9484901; Product type e : enzyme; pyruvate formate-lyase 4/2-ketobutyrate formate-lyase 3348879 tdcE 7126229 tdcE Escherichia coli IAI1 pyruvate formate-lyase 4/2-ketobutyrate formate-lyase YP_002388598.1 3346585 R 585034 CDS YP_002388599.1 218555686 7126228 complement(3348913..3350133) 1 NC_011741.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase 3350133 tdcD 7126228 tdcD Escherichia coli IAI1 propionate/acetate kinase YP_002388599.1 3348913 R 585034 CDS YP_002388600.1 218555687 7126227 complement(3350147..3351478) 1 NC_011741.1 involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC 3351478 tdcC 7126227 tdcC Escherichia coli IAI1 threonine/serine transporter TdcC YP_002388600.1 3350147 R 585034 CDS YP_002388601.1 218555688 7126226 complement(3351500..3352489) 1 NC_011741.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase 3352489 tdcB 7126226 tdcB Escherichia coli IAI1 threonine dehydratase YP_002388601.1 3351500 R 585034 CDS YP_002388602.1 218555689 7126225 complement(3352588..3353526) 1 NC_011741.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA 3353526 tdcA 7126225 tdcA Escherichia coli IAI1 DNA-binding transcriptional activator TdcA YP_002388602.1 3352588 R 585034 CDS YP_002388603.1 218555690 7126224 3353703..3354059 1 NC_011741.1 participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 3354059 tdcR 7126224 tdcR Escherichia coli IAI1 DNA-binding transcriptional activator TdcR YP_002388603.1 3353703 D 585034 CDS YP_002388604.1 218555691 7126231 3354315..3354854 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3354854 yhaB 7126231 yhaB Escherichia coli IAI1 hypothetical protein YP_002388604.1 3354315 D 585034 CDS YP_002388605.1 218555692 7128735 3354876..3356063 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1705543, 2573820, 2660107, 6351058; hypothetical protein 3356063 yhaC 7128735 yhaC Escherichia coli IAI1 hypothetical protein YP_002388605.1 3354876 D 585034 CDS YP_002388606.1 218555693 7128736 3356124..3356288 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3356288 7128736 ECIAI1_3271 Escherichia coli IAI1 hypothetical protein YP_002388606.1 3356124 D 585034 CDS YP_002388607.1 218555694 7125502 complement(3356867..3358093) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20225875, 69151449, 9772162; Product type e : enzyme; glycerate kinase I 3358093 garK 7125502 garK Escherichia coli IAI1 glycerate kinase I YP_002388607.1 3356867 R 585034 CDS YP_002388608.1 218555695 7128280 complement(3358109..3358999) 1 NC_011741.1 catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase 3358999 garR 7128280 garR Escherichia coli IAI1 tartronate semialdehyde reductase YP_002388608.1 3358109 R 585034 CDS YP_002388609.1 218555696 7128283 complement(3359029..3359799) 1 NC_011741.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase 3359799 garL 7128283 garL Escherichia coli IAI1 alpha-dehydro-beta-deoxy-D-glucarate aldolase YP_002388609.1 3359029 R 585034 CDS YP_002388610.1 218555697 7128281 complement(3359815..3361149) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10762278, 9772162; Product type pt : putative transporter; putative (D)-galactarate transporter 3361149 garP 7128281 garP Escherichia coli IAI1 putative (D)-galactarate transporter YP_002388610.1 3359815 R 585034 CDS YP_002388611.1 218555698 7128282 3361524..3363095 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20225875, 66096392, 81027430, 9772162, 10762278, 2407727; Product type e : enzyme; (D)-galactarate dehydrogenase 3363095 garD 7128282 garD Escherichia coli IAI1 (D)-galactarate dehydrogenase YP_002388611.1 3361524 D 585034 CDS YP_002388612.1 218555699 7128279 3363244..3363579 1 NC_011741.1 SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation; putative regulator PrlF 3363579 sohA 7128279 sohA Escherichia coli IAI1 putative regulator PrlF YP_002388612.1 3363244 D 585034 CDS YP_002388613.1 218555700 7127944 3363579..3364043 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3364043 yhaV 7127944 yhaV Escherichia coli IAI1 hypothetical protein YP_002388613.1 3363579 D 585034 CDS YP_002388614.1 218555701 7128744 complement(3364098..3364907) 1 NC_011741.1 transcriptional repressor for the agaZVWA and agaSYBCDI operons; DNA-binding transcriptional regulator AgaR 3364907 agaR 7128744 agaR Escherichia coli IAI1 DNA-binding transcriptional regulator AgaR YP_002388614.1 3364098 R 585034 CDS YP_002388615.1 218555702 7125732 3365156..3366436 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976750, 20392444, 10931310, 8932697; Product type e : enzyme; tagatose 6-phosphate aldolase 1, kbaZ subunit 3366436 kbaZ 7125732 kbaZ Escherichia coli IAI1 tagatose 6-phosphate aldolase 1, kbaZ subunit YP_002388615.1 3365156 D 585034 CDS YP_002388616.1 218555703 7126095 3366459..3366932 1 NC_011741.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3366932 agaV 7126095 agaV Escherichia coli IAI1 PTS system N-acetylgalactosamine-specific transporter subunit IIB YP_002388616.1 3366459 D 585034 CDS YP_002388617.1 218555704 7125734 3366943..3367722 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative PTS system transporter subunit IIC 3367722 7125734 ECIAI1_3282 Escherichia coli IAI1 putative PTS system transporter subunit IIC YP_002388617.1 3366943 D 585034 CDS YP_002388618.1 218555705 7125600 3367706..3368590 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative hexose/hexosamine family PTS permease IID component 3368590 7125600 ECIAI1_3283 Escherichia coli IAI1 putative hexose/hexosamine family PTS permease IID component YP_002388618.1 3367706 D 585034 CDS YP_002388619.1 218555706 7125601 3368608..3369042 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system enzyme subunit (N-acetyl-galactosamine / galactosamine PTS system enzyme IIA component) 3369042 7125601 ECIAI1_3284 Escherichia coli IAI1 putative phosphotransferase system enzyme subunit (N-acetyl-galactosamine / galactosamine PTS system enzyme IIA component) YP_002388619.1 3368608 D 585034 CDS YP_002388620.1 218555707 7125602 3369018..3370172 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; N-acetylglucosamine-6-phosphate deacetylase 3370172 agaA 7125602 agaA Escherichia coli IAI1 N-acetylglucosamine-6-phosphate deacetylase YP_002388620.1 3369018 D 585034 CDS YP_002388621.1 218555708 7125727 3370523..3371677 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689210, 9697096, 14731281, 8932697; Product type e : enzyme; tagatose-6-phosphate ketose/aldose isomerase 3371677 agaS 7125727 agaS Escherichia coli IAI1 tagatose-6-phosphate ketose/aldose isomerase YP_002388621.1 3370523 D 585034 CDS YP_002388622.1 218555709 7125733 3371690..3372550 1 NC_011741.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 3372550 kbaY 7125733 kbaY Escherichia coli IAI1 tagatose-bisphosphate aldolase YP_002388622.1 3371690 D 585034 CDS YP_002388623.1 218555710 7126094 3372717..3373193 1 NC_011741.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3373193 agaB 7126094 agaB Escherichia coli IAI1 PTS system N-acetylgalactosamine-specific transporter subunit IIB YP_002388623.1 3372717 D 585034 CDS YP_002388624.1 218555711 7125728 3373232..3374035 1 NC_011741.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIC 3374035 agaC 7125728 agaC Escherichia coli IAI1 PTS system N-acetylgalactosamine-specific transporter subunit IIC YP_002388624.1 3373232 D 585034 CDS YP_002388625.1 218555712 7125729 3374025..3374816 1 NC_011741.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IID 3374816 agaD 7125729 agaD Escherichia coli IAI1 PTS system N-acetylgalactosamine-specific transporter subunit IID YP_002388625.1 3374025 D 585034 CDS YP_002388626.1 218555713 7125730 3374817..3375572 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10931310; Product type e : enzyme; galactosamine-6-phosphate isomerase 3375572 agaI 7125730 agaI Escherichia coli IAI1 galactosamine-6-phosphate isomerase YP_002388626.1 3374817 D 585034 CDS YP_002388627.1 218555714 7125731 3375972..3376556 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein 3376556 yraH 7125731 yraH Escherichia coli IAI1 putative fimbrial-like adhesin protein YP_002388627.1 3375972 D 585034 CDS YP_002388628.1 218555715 7128073 3376636..3377331 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11677609; Product type f : factor; periplasmic pilin chaperone 3377331 yraI 7128073 yraI Escherichia coli IAI1 periplasmic pilin chaperone YP_002388628.1 3376636 D 585034 CDS YP_002388629.1 218555716 7128074 3377361..3379877 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane protein 3379877 yraJ 7128074 yraJ Escherichia coli IAI1 putative outer membrane protein YP_002388629.1 3377361 D 585034 CDS YP_002388630.1 218555717 7128075 3379888..3380979 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein 3380979 yraK 7128075 yraK Escherichia coli IAI1 putative fimbrial-like adhesin protein YP_002388630.1 3379888 D 585034 CDS YP_002388631.1 218555718 7128076 complement(3381022..3381882) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase 3381882 yraL 7128076 yraL Escherichia coli IAI1 putative methyltransferase YP_002388631.1 3381022 R 585034 CDS YP_002388632.1 218555719 7128077 3381946..3383982 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3383982 yraM 7128077 yraM Escherichia coli IAI1 hypothetical protein YP_002388632.1 3381946 D 585034 CDS YP_002388633.1 218555720 7128078 3383940..3384335 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3384335 yraN 7128078 yraN Escherichia coli IAI1 hypothetical protein YP_002388633.1 3383940 D 585034 CDS YP_002388634.1 218555721 7128079 3384355..3384945 1 NC_011741.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; DnaA initiator-associating protein DiaA 3384945 yraO 7128079 yraO Escherichia coli IAI1 DnaA initiator-associating protein DiaA YP_002388634.1 3384355 D 585034 CDS YP_002388635.1 218555722 7128080 3384955..3385530 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3385530 ecfH 7128080 ecfH Escherichia coli IAI1 hypothetical protein YP_002388635.1 3384955 D 585034 CDS YP_002388636.1 218555723 7125043 complement(3385644..3386684) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease 3386684 yraQ 7125043 yraQ Escherichia coli IAI1 putative permease YP_002388636.1 3385644 R 585034 CDS YP_002388637.1 218555724 7128081 complement(3386757..3387392) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleoside-diphosphate-sugar epimerase 3387392 yraR 7128081 yraR Escherichia coli IAI1 putative nucleoside-diphosphate-sugar epimerase YP_002388637.1 3386757 R 585034 CDS YP_002388638.1 218555725 7128082 3387520..3388038 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative intracellular protease 3388038 yhbO 7128082 yhbO Escherichia coli IAI1 putative intracellular protease YP_002388638.1 3387520 D 585034 CDS YP_002388639.1 218555726 7128749 complement(3388018..3388461) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3388461 yhbP 7128749 yhbP Escherichia coli IAI1 hypothetical protein YP_002388639.1 3388018 R 585034 CDS YP_002388640.1 218555727 7128750 3388512..3388814 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; GIY-YIG nuclease superfamily protein 3388814 yhbQ 7128750 yhbQ Escherichia coli IAI1 GIY-YIG nuclease superfamily protein YP_002388640.1 3388512 D 585034 CDS YP_002388641.1 218555728 7128751 complement(3388801..3389304) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyltransferase with acyl-CoA N-acyltransferase domain 3389304 yhbS 7128751 yhbS Escherichia coli IAI1 putative acyltransferase with acyl-CoA N-acyltransferase domain YP_002388641.1 3388801 R 585034 CDS YP_002388642.1 218555729 7128752 complement(3389298..3389822) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative lipid carrier protein 3389822 yhbT 7128752 yhbT Escherichia coli IAI1 putative lipid carrier protein YP_002388642.1 3389298 R 585034 CDS YP_002388643.1 218555730 7128753 3390031..3391026 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10206698; Product type e : enzyme; peptidase 3391026 yhbU 7128753 yhbU Escherichia coli IAI1 peptidase YP_002388643.1 3390031 D 585034 CDS YP_002388644.1 218555731 7128754 3391035..3391913 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10206698; Product type e : enzyme; protease 3391913 yhbV 7128754 yhbV Escherichia coli IAI1 protease YP_002388644.1 3391035 D 585034 CDS YP_002388645.1 218555732 7128755 3392119..3393126 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3393126 yhbW 7128755 yhbW Escherichia coli IAI1 hypothetical protein YP_002388645.1 3392119 D 585034 CDS YP_002388646.1 218555733 7128756 complement(3393244..3394488) 1 NC_011741.1 tryptophan transporter of high affinity; tryptophan permease 3394488 mtr 7128756 mtr Escherichia coli IAI1 tryptophan permease YP_002388646.1 3393244 R 585034 CDS YP_002388647.1 218555734 7124488 complement(3394642..3396531) 1 NC_011741.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD 3396531 deaD 7124488 deaD Escherichia coli IAI1 ATP-dependent RNA helicase DeaD YP_002388647.1 3394642 R 585034 CDS YP_002388648.1 218555735 7124556 complement(3396711..3397595) 1 NC_011741.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI 3397595 nlpI 7124556 nlpI Escherichia coli IAI1 lipoprotein NlpI YP_002388648.1 3396711 R 585034 CDS YP_002388649.1 218555736 7127892 complement(3397704..3399908) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87083499, 91198209, 99234021, 99340204, 2432069, 3005122, 6382163, 9008164, 9298646; Product type e : enzyme; polynucleotide phosphorylase/polyadenylase 3399908 pnp 7127892 pnp Escherichia coli IAI1 polynucleotide phosphorylase/polyadenylase YP_002388649.1 3397704 R 585034 CDS YP_002388650.1 218555737 7127970 complement(3400086..3400355) 1 NC_011741.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 3400355 rpsO 7127970 rpsO Escherichia coli IAI1 30S ribosomal protein S15 YP_002388650.1 3400086 R 585034 CDS YP_002388651.1 218555738 7128421 complement(3400504..3401448) 1 NC_011741.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 3401448 truB 7128421 truB Escherichia coli IAI1 tRNA pseudouridine synthase B YP_002388651.1 3400504 R 585034 CDS YP_002388652.1 218555739 7127503 complement(3401448..3401849) 1 NC_011741.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 3401849 rbfA 7127503 rbfA Escherichia coli IAI1 ribosome-binding factor A YP_002388652.1 3401448 R 585034 CDS YP_002388653.1 218555740 7126590 complement(3402013..3404685) 1 NC_011741.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 3404685 infB 7126590 infB Escherichia coli IAI1 translation initiation factor IF-2 YP_002388653.1 3402013 R 585034 CDS YP_002388654.1 218555741 7126065 complement(3404710..3406197) 1 NC_011741.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 3406197 nusA 7126065 nusA Escherichia coli IAI1 transcription elongation factor NusA YP_002388654.1 3404710 R 585034 CDS YP_002388655.1 218555742 7125973 complement(3406225..3406677) 1 NC_011741.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 3406677 yhbC 7125973 yhbC Escherichia coli IAI1 hypothetical protein YP_002388655.1 3406225 R 585034 CDS YP_002388656.1 218555743 7128039 3407308..3408651 1 NC_011741.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 3408651 argG 7128039 argG Escherichia coli IAI1 argininosuccinate synthase YP_002388656.1 3407308 D 585034 CDS YP_002388657.1 218555744 7125791 complement(3408659..3410284) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase, inner membrane 3410284 yhbX 7125791 yhbX Escherichia coli IAI1 putative hydrolase, inner membrane YP_002388657.1 3408659 R 585034 CDS YP_002388658.1 218555745 7128037 complement(3410844..3411176) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20194819, 21125563, 9020118, 94074540, 9564033, 9644254, 9829959, 99298179, 7556084, 8034620, 8045257, 8244950, 8253068; Product type t : transporter; preprotein translocase subunit SecG 3411176 secG 7128037 secG Escherichia coli IAI1 preprotein translocase subunit SecG YP_002388658.1 3410844 R 585034 CDS YP_002388659.1 218555746 7124696 complement(3411404..3412741) 1 NC_011741.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 3412741 glmM 7124696 glmM Escherichia coli IAI1 phosphoglucosamine mutase YP_002388659.1 3411404 R 585034 CDS YP_002388660.1 218555747 7128318 complement(3412734..3413582) 1 NC_011741.1 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase 3413582 folP 7128318 folP Escherichia coli IAI1 dihydropteroate synthase YP_002388660.1 3412734 R 585034 CDS YP_002388661.1 218555748 7127266 complement(3413672..3415606) 1 NC_011741.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease 3415606 hflB 7127266 hflB Escherichia coli IAI1 ATP-dependent metalloprotease YP_002388661.1 3413672 R 585034 CDS YP_002388662.1 218555749 7128235 complement(3415706..3416335) 1 NC_011741.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase J 3416335 rrmJ 7128235 rrmJ Escherichia coli IAI1 23S rRNA methyltransferase J YP_002388662.1 3415706 R 585034 CDS YP_002388663.1 218555750 7128430 3416461..3416754 1 NC_011741.1 RNA binding protein found associated to pre-50S subunit of the ribosome; putative role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 3416754 yhbY 7128430 yhbY Escherichia coli IAI1 RNA-binding protein YhbY YP_002388663.1 3416461 D 585034 CDS YP_002388664.1 218555751 7128758 complement(3416910..3417386) 1 NC_011741.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 3417386 greA 7128758 greA Escherichia coli IAI1 transcription elongation factor GreA YP_002388664.1 3416910 R 585034 CDS YP_002388665.1 218555752 7128463 3417634..3419067 1 NC_011741.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase/endopeptidase 3419067 dacB 7128463 dacB Escherichia coli IAI1 D-alanyl-D-alanine carboxypeptidase/endopeptidase YP_002388665.1 3417634 D 585034 CDS YP_002388666.1 218555753 7126909 complement(3419107..3420279) 1 NC_011741.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 3420279 obgE 7126909 obgE Escherichia coli IAI1 GTPase ObgE YP_002388666.1 3419107 R 585034 CDS YP_002388667.1 218555754 7125976 complement(3420295..3421260) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3421260 yhbE 7125976 yhbE Escherichia coli IAI1 hypothetical protein YP_002388667.1 3420295 R 585034 CDS YP_002388668.1 218555755 7128746 complement(3421387..3421644) 1 NC_011741.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 3421644 rpmA 7128746 rpmA Escherichia coli IAI1 50S ribosomal protein L27 YP_002388668.1 3421387 R 585034 CDS YP_002388669.1 218555756 7128387 complement(3421665..3421976) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91088242, 94146411, 10094780, 387076, 8312607; Product type s : structure; 50S ribosomal protein L21 3421976 rplU 7128387 rplU Escherichia coli IAI1 50S ribosomal protein L21 YP_002388669.1 3421665 R 585034 CDS YP_002388670.1 218555757 7128382 3422235..3423206 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94311902, 97284515, 2670911, 8037730, 8312607; Product type e : enzyme; octaprenyl diphosphate synthase 3423206 ispB 7128382 ispB Escherichia coli IAI1 octaprenyl diphosphate synthase YP_002388670.1 3422235 D 585034 CDS YP_002388671.1 218555758 7126080 3423434..3423712 1 NC_011741.1 activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 3423712 sfsB 7126080 sfsB Escherichia coli IAI1 DNA-binding transcriptional regulator Nlp YP_002388671.1 3423434 D 585034 CDS YP_002388672.1 218555759 7127922 complement(3423760..3425019) 1 NC_011741.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 3425019 murA 7127922 murA Escherichia coli IAI1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_002388672.1 3423760 R 585034 CDS YP_002388673.1 218555760 7124492 complement(3425074..3425328) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3425328 yrbA 7124492 yrbA Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002388673.1 3425074 R 585034 CDS YP_002388674.1 218555761 7128083 complement(3425488..3425781) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3425781 yrbB 7128083 yrbB Escherichia coli IAI1 hypothetical protein YP_002388674.1 3425488 R 585034 CDS YP_002388675.1 218555762 7128084 complement(3425781..3426416) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene ABC transporter membrane protein 3426416 yrbC 7128084 yrbC Escherichia coli IAI1 toluene ABC transporter membrane protein YP_002388675.1 3425781 R 585034 CDS YP_002388676.1 218555763 7128085 complement(3426435..3426986) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene ABC transporter membrane protein 3426986 yrbD 7128085 yrbD Escherichia coli IAI1 toluene ABC transporter membrane protein YP_002388676.1 3426435 R 585034 CDS YP_002388677.1 218555764 7128086 complement(3426991..3427773) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene ABC transporter membrane protein 3427773 yrbE 7128086 yrbE Escherichia coli IAI1 toluene ABC transporter membrane protein YP_002388677.1 3426991 R 585034 CDS YP_002388678.1 218555765 7128087 complement(3427781..3428590) 1 NC_011741.1 ATP-binding subunit of a putative ABC toluene efflux transporter; putative ABC transporter ATP-binding protein YrbF 3428590 yrbF 7128087 yrbF Escherichia coli IAI1 putative ABC transporter ATP-binding protein YrbF YP_002388678.1 3427781 R 585034 CDS YP_002388679.1 218555766 7128088 3428800..3429777 1 NC_011741.1 YrbG; inner membrane protein involved in cell envelope integrity; putative sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; putative calcium/sodium:proton antiporter 3429777 yrbG 7128088 yrbG Escherichia coli IAI1 putative calcium/sodium:proton antiporter YP_002388679.1 3428800 D 585034 CDS YP_002388680.1 218555767 7128089 3429791..3430777 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12805358; Product type e : enzyme; D-arabinose 5-phosphate isomerase 3430777 kdsD 7128089 kdsD Escherichia coli IAI1 D-arabinose 5-phosphate isomerase YP_002388680.1 3429791 D 585034 CDS YP_002388681.1 218555768 7126381 3430798..3431364 1 NC_011741.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 3431364 kdsC 7126381 kdsC Escherichia coli IAI1 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase YP_002388681.1 3430798 D 585034 CDS YP_002388682.1 218555769 7126380 3431361..3431936 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3431936 yrbK 7126380 yrbK Escherichia coli IAI1 hypothetical protein YP_002388682.1 3431361 D 585034 CDS YP_002388683.1 218555770 7128090 3431905..3432462 1 NC_011741.1 LptA; periplasmic binding protein part of a putative ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 3432462 lptA 7128090 lptA Escherichia coli IAI1 lipopolysaccharide transport periplasmic protein LptA YP_002388683.1 3431905 D 585034 CDS YP_002388684.1 218555771 7127620 3432469..3433194 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7876255, 9298646, 17056748; Product type pt : putative transporter; putative ABC transporter ATP-binding protein YhbG 3433194 lptB 7127620 lptB Escherichia coli IAI1 putative ABC transporter ATP-binding protein YhbG YP_002388684.1 3432469 D 585034 CDS YP_002388685.1 218555772 7127621 3433242..3434675 1 NC_011741.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 3434675 rpoN 7127621 rpoN Escherichia coli IAI1 RNA polymerase factor sigma-54 YP_002388685.1 3433242 D 585034 CDS YP_002388686.1 218555773 7128402 3434698..3434985 1 NC_011741.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; putative sigma(54) modulation protein 3434985 yhbH 7128402 yhbH Escherichia coli IAI1 putative sigma(54) modulation protein YP_002388686.1 3434698 D 585034 CDS YP_002388687.1 218555774 7128747 3435103..3435594 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88212176, 90136533, 90274974, 95020584, 95181483, 7876255, 8025669, 8444818, 9636714; Product type t : transporter; PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN 3435594 ptsN 7128747 ptsN Escherichia coli IAI1 PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN YP_002388687.1 3435103 D 585034 CDS YP_002388688.1 218555775 7126542 3435640..3436494 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3436494 yhbJ 7126542 yhbJ Escherichia coli IAI1 hypothetical protein YP_002388688.1 3435640 D 585034 CDS YP_002388689.1 218555776 7128748 3436491..3436763 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10473571, 95181483, 7876255, 8025669; Product type t : transporter; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 3436763 npr 7128748 npr Escherichia coli IAI1 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) YP_002388689.1 3436491 D 585034 CDS YP_002388690.1 218555777 7127899 3436977..3437609 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 89083480; hypothetical protein 3437609 yrbL 7127899 yrbL Escherichia coli IAI1 hypothetical protein YP_002388690.1 3436977 D 585034 CDS YP_002388691.1 218555778 7128091 complement(3437606..3438334) 1 NC_011741.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase 3438334 mtgA 7128091 mtgA Escherichia coli IAI1 monofunctional biosynthetic peptidoglycan transglycosylase YP_002388691.1 3437606 R 585034 CDS YP_002388692.1 218555779 7124484 complement(3438331..3438984) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92246944, 98269038, 1575737, 9603997; Product type pe : putative enzyme; isoprenoid biosynthesis protein 3438984 elbB 7124484 elbB Escherichia coli IAI1 isoprenoid biosynthesis protein YP_002388692.1 3438331 R 585034 CDS YP_002388693.1 218555780 7124663 complement(3439214..3441550) 1 NC_011741.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB 3441550 arcB 7124663 arcB Escherichia coli IAI1 aerobic respiration control sensor protein ArcB YP_002388693.1 3439214 R 585034 CDS YP_002388694.1 218555781 7125785 complement(3441646..3442575) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Fe-S oxidoreductase 3442575 yhcC 7125785 yhcC Escherichia coli IAI1 putative Fe-S oxidoreductase YP_002388694.1 3441646 R 585034 CDS YP_002388695.1 218555782 7128760 3443157..3447710 1 NC_011741.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase subunit alpha 3447710 gltB 7128760 gltB Escherichia coli IAI1 glutamate synthase subunit alpha YP_002388695.1 3443157 D 585034 CDS YP_002388696.1 218555783 7128347 3447723..3449141 1 NC_011741.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 3449141 gltD 7128347 gltD Escherichia coli IAI1 glutamate synthase subunit beta YP_002388696.1 3447723 D 585034 CDS YP_002388697.1 218555784 7128348 3449325..3450452 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3450452 yhcG 7128348 yhcG Escherichia coli IAI1 hypothetical protein YP_002388697.1 3449325 D 585034 CDS YP_002388698.1 218555785 7128761 complement(3450512..3450976) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3450976 yhcH 7128761 yhcH Escherichia coli IAI1 hypothetical protein YP_002388698.1 3450512 R 585034 CDS YP_002388699.1 218555786 7128762 complement(3450988..3451887) 1 NC_011741.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 3451887 nanK 7128762 nanK Escherichia coli IAI1 N-acetylmannosamine kinase YP_002388699.1 3450988 R 585034 CDS YP_002388700.1 218555787 7124525 complement(3451845..3452534) 1 NC_011741.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 3452534 nanE 7124525 nanE Escherichia coli IAI1 N-acetylmannosamine-6-phosphate 2-epimerase YP_002388700.1 3451845 R 585034 CDS YP_002388701.1 218555788 7124524 complement(3452582..3454072) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96011396, 9864311, 7592358; Product type t : transporter; putative sialic acid transporter 3454072 nanT 7124524 nanT Escherichia coli IAI1 putative sialic acid transporter YP_002388701.1 3452582 R 585034 CDS YP_002388702.1 218555789 7124527 complement(3454181..3455074) 1 NC_011741.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 3455074 nanA 7124527 nanA Escherichia coli IAI1 N-acetylneuraminate lyase YP_002388702.1 3454181 R 585034 CDS YP_002388703.1 218555790 7124523 complement(3455196..3455987) 1 NC_011741.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR 3455987 nanR 7124523 nanR Escherichia coli IAI1 transcriptional regulator NanR YP_002388703.1 3455196 R 585034 CDS YP_002388704.1 218555791 7124526 3456367..3457734 1 NC_011741.1 YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic; putative cryptic C4-dicarboxylate transporter DcuD 3457734 dcuD 7124526 dcuD Escherichia coli IAI1 putative cryptic C4-dicarboxylate transporter DcuD YP_002388704.1 3456367 D 585034 CDS YP_002388705.1 218555792 7124543 complement(3457777..3458274) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12445774, 94293773, 1721886, 3029697, 8022275; Product type f : factor; ClpXP protease specificity-enhancing factor 3458274 sspB 7124543 sspB Escherichia coli IAI1 ClpXP protease specificity-enhancing factor YP_002388705.1 3457777 R 585034 CDS YP_002388706.1 218555793 7127984 complement(3458280..3458918) 1 NC_011741.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A 3458918 sspA 7127984 sspA Escherichia coli IAI1 stringent starvation protein A YP_002388706.1 3458280 R 585034 CDS YP_002388707.1 218555794 7127983 complement(3459313..3459705) 1 NC_011741.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 3459705 rpsI 7127983 rpsI Escherichia coli IAI1 30S ribosomal protein S9 YP_002388707.1 3459313 R 585034 CDS YP_002388708.1 218555795 7128415 complement(3459721..3460149) 1 NC_011741.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 3460149 rplM 7128415 rplM Escherichia coli IAI1 50S ribosomal protein L13 YP_002388708.1 3459721 R 585034 CDS YP_002388709.1 218555796 7128374 complement(3460368..3461495) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3461495 yhcM 7128374 yhcM Escherichia coli IAI1 hypothetical protein YP_002388709.1 3460368 R 585034 CDS YP_002388710.1 218555797 7128763 3461689..3462087 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16079137; Product type pe : putative enzyme; cytochrome d ubiquinol oxidase subunit III 3462087 yhcB 7128763 yhcB Escherichia coli IAI1 cytochrome d ubiquinol oxidase subunit III YP_002388710.1 3461689 D 585034 CDS YP_002388711.1 218555798 7128759 3462241..3463608 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8830688, 96165272, 8576051, 8576052, 9740056; Product type e : enzyme; serine endoprotease 3463608 degQ 7128759 degQ Escherichia coli IAI1 serine endoprotease YP_002388711.1 3462241 D 585034 CDS YP_002388712.1 218555799 7124561 3463698..3464765 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15137941, 15225661, 21352996, 96165272, 99431977, 3322223, 8576051; Product type e : enzyme; serine endoprotease 3464765 degS 7124561 degS Escherichia coli IAI1 serine endoprotease YP_002388712.1 3463698 D 585034 CDS YP_002388713.1 218555800 7124562 complement(3464828..3465766) 1 NC_011741.1 oxidizes malate to oxaloacetate; malate dehydrogenase 3465766 mdh 7124562 mdh Escherichia coli IAI1 malate dehydrogenase YP_002388713.1 3464828 R 585034 CDS YP_002388714.1 218555801 7127680 3466201..3466671 1 NC_011741.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 3466671 argR 7127680 argR Escherichia coli IAI1 arginine repressor YP_002388714.1 3466201 D 585034 CDS YP_002388715.1 218555802 7125797 3467036..3467299 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3467299 yhcN 7125797 yhcN Escherichia coli IAI1 hypothetical protein YP_002388715.1 3467036 D 585034 CDS YP_002388716.1 218555803 7128764 complement(3467355..3467627) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative barnase inhibitor 3467627 yhcO 7128764 yhcO Escherichia coli IAI1 putative barnase inhibitor YP_002388716.1 3467355 R 585034 CDS YP_002388717.1 218555804 7128765 complement(3467719..3469686) 1 NC_011741.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB 3469686 aaeB 7128765 aaeB Escherichia coli IAI1 p-hydroxybenzoic acid efflux subunit AaeB YP_002388717.1 3467719 R 585034 CDS YP_002388718.1 218555805 7125676 complement(3469692..3470624) 1 NC_011741.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA 3470624 aaeA 7125676 aaeA Escherichia coli IAI1 p-hydroxybenzoic acid efflux subunit AaeA YP_002388718.1 3469692 R 585034 CDS YP_002388719.1 218555806 7125675 complement(3470632..3470835) 1 NC_011741.1 membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein 3470835 aaeX 7125675 aaeX Escherichia coli IAI1 hypothetical protein YP_002388719.1 3470632 R 585034 CDS YP_002388720.1 218555807 7125678 3471018..3471947 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15489430; Product type r : regulator; putative DNA-binding transcriptional regulator 3471947 aaeR 7125678 aaeR Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002388720.1 3471018 D 585034 CDS YP_002388721.1 218555808 7125677 complement(3472075..3473520) 1 NC_011741.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD 3473520 tldD 7125677 tldD Escherichia coli IAI1 protease TldD YP_002388721.1 3472075 R 585034 CDS YP_002388722.1 218555809 7127453 complement(3473676..3477476) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10960106; Product type pm : putative membrane component; hypothetical protein 3477476 yhdP 7127453 yhdP Escherichia coli IAI1 hypothetical protein YP_002388722.1 3473676 R 585034 CDS YP_002388723.1 218555810 7128771 complement(3477544..3479013) 1 NC_011741.1 involved in the processing of the 5'end of 16S rRNA; ribonuclease G 3479013 rng 7128771 rng Escherichia coli IAI1 ribonuclease G YP_002388723.1 3477544 R 585034 CDS YP_002388724.1 218555811 7125021 complement(3479003..3479596) 1 NC_011741.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 3479596 yhdE 7125021 yhdE Escherichia coli IAI1 Maf-like protein YP_002388724.1 3479003 R 585034 CDS YP_002388725.1 218555812 7128766 complement(3479605..3480093) 1 NC_011741.1 part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD 3480093 mreD 7128766 mreD Escherichia coli IAI1 rod shape-determining protein MreD YP_002388725.1 3479605 R 585034 CDS YP_002388726.1 218555813 7124476 complement(3480077..3480208) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 3480208 7124476 ECIAI1_3391 Escherichia coli IAI1 hypothetical protein YP_002388726.1 3480077 R 585034 CDS YP_002388727.1 218555814 7125603 complement(3480093..3481196) 1 NC_011741.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 3481196 mreC 7125603 mreC Escherichia coli IAI1 rod shape-determining protein MreC YP_002388727.1 3480093 R 585034 CDS YP_002388728.1 218555815 7124475 complement(3481262..3482305) 1 NC_011741.1 functions in MreBCD complex in some organisms; rod shape-determining protein MreB 3482305 mreB 7124475 mreB Escherichia coli IAI1 rod shape-determining protein MreB YP_002388728.1 3481262 R 585034 CDS YP_002388729.1 218555816 7124474 3482413..3482601 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 3482601 7124474 ECIAI1_3394 Escherichia coli IAI1 hypothetical protein YP_002388729.1 3482413 D 585034 CDS YP_002388730.1 218555817 7125604 complement(3482610..3484550) 1 NC_011741.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD 3484550 csrD 7125604 csrD Escherichia coli IAI1 regulatory protein CsrD YP_002388730.1 3482610 R 585034 CDS YP_002388731.1 218555818 7126855 3484702..3485676 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 3485676 yhdH 7126855 yhdH Escherichia coli IAI1 putative oxidoreductase YP_002388731.1 3484702 D 585034 CDS YP_002388732.1 218555819 7128767 3486654..3487124 1 NC_011741.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3487124 accB 7128767 accB Escherichia coli IAI1 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_002388732.1 3486654 D 585034 CDS YP_002388733.1 218555820 7125691 3487135..3488484 1 NC_011741.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 3488484 accC 7125691 accC Escherichia coli IAI1 acetyl-CoA carboxylase biotin carboxylase subunit YP_002388733.1 3487135 D 585034 CDS YP_002388734.1 218555821 7125692 3488593..3488835 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3488835 yhdT 7125692 yhdT Escherichia coli IAI1 hypothetical protein YP_002388734.1 3488593 D 585034 CDS YP_002388735.1 218555822 7128772 3488825..3490276 1 NC_011741.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 3490276 panF 7128772 panF Escherichia coli IAI1 sodium/panthothenate symporter YP_002388735.1 3488825 D 585034 CDS YP_002388736.1 218555823 7124154 3490288..3491169 1 NC_011741.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 3491169 prmA 7124154 prmA Escherichia coli IAI1 ribosomal protein L11 methyltransferase YP_002388736.1 3490288 D 585034 CDS YP_002388737.1 218555824 7126153 3491498..3492463 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566, 1459953, 1547773, 2835774, 2837762, 8226664; Product type e : enzyme; tRNA-dihydrouridine synthase B 3492463 dusB 7126153 dusB Escherichia coli IAI1 tRNA-dihydrouridine synthase B YP_002388737.1 3491498 D 585034 CDS YP_002388738.1 218555825 7125032 3492489..3492785 1 NC_011741.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 3492785 fis 7125032 fis Escherichia coli IAI1 DNA-binding protein Fis YP_002388738.1 3492489 D 585034 CDS YP_002388739.1 218555826 7127120 3492871..3493755 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15028690, 9073062; Product type e : enzyme; putative methyltransferase 3493755 yhdJ 7127120 yhdJ Escherichia coli IAI1 putative methyltransferase YP_002388739.1 3492871 D 585034 CDS YP_002388740.1 218555827 7128768 3493839..3494018 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3494018 yhdU 7128768 yhdU Escherichia coli IAI1 hypothetical protein YP_002388740.1 3493839 D 585034 CDS YP_002388741.1 218555828 7128773 complement(3494021..3494683) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8203018, 11257026, 8407802, 1720861; Product type r : regulator; DNA-binding transcriptional regulator EnvR 3494683 envR 7128773 envR Escherichia coli IAI1 DNA-binding transcriptional regulator EnvR YP_002388741.1 3494021 R 585034 CDS YP_002388742.1 218555829 7125075 3495082..3496239 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012493, 1720861; Product type lp : lipoprotein; cytoplasmic membrane lipoprotein 3496239 acrE 7125075 acrE Escherichia coli IAI1 cytoplasmic membrane lipoprotein YP_002388742.1 3495082 D 585034 CDS YP_002388743.1 218555830 7125709 3496251..3499355 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94262163, 99449638, 1720861, 8407802; Product type t : transporter; multidrug efflux system protein 3499355 acrF 7125709 acrF Escherichia coli IAI1 multidrug efflux system protein YP_002388743.1 3496251 D 585034 CDS YP_002388744.1 218555831 7125710 3499608..3499829 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3499829 yhdV 7125710 yhdV Escherichia coli IAI1 hypothetical protein YP_002388744.1 3499608 D 585034 CDS YP_002388745.1 218555832 7128774 3500055..3500231 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3500231 7128774 ECIAI1_3411 Escherichia coli IAI1 hypothetical protein YP_002388745.1 3500055 D 585034 CDS YP_002388746.1 218555833 7125605 3500368..3501285 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid ABC transporter periplasmic-binding protein 3501285 aapJ 7125605 aapJ Escherichia coli IAI1 amino-acid ABC transporter periplasmic-binding protein YP_002388746.1 3500368 D 585034 CDS YP_002388747.1 218555834 7125679 3501353..3502534 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid ABC transporter membrane protein 3502534 aapQ 7125679 aapQ Escherichia coli IAI1 amino-acid ABC transporter membrane protein YP_002388747.1 3501353 D 585034 CDS YP_002388748.1 218555835 7125682 3502544..3503647 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid ABC transporter membrane protein 3503647 aapM 7125682 aapM Escherichia coli IAI1 amino-acid ABC transporter membrane protein YP_002388748.1 3502544 D 585034 CDS YP_002388749.1 218555836 7125680 3503655..3504413 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8809753, 8898392; Product type t : transporter; amino-acid ABC transporter ATP-binding protein 3504413 aapP 7125680 aapP Escherichia coli IAI1 amino-acid ABC transporter ATP-binding protein YP_002388749.1 3503655 D 585034 CDS YP_002388750.1 218555837 7126786 3510294..3510848 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3510848 yrdA 7126786 yrdA Escherichia coli IAI1 hypothetical protein YP_002388750.1 3510294 D 585034 CDS YP_002388751.1 218555838 7128092 complement(3510824..3511081) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3511081 yrdB 7128092 yrdB Escherichia coli IAI1 hypothetical protein YP_002388751.1 3510824 R 585034 CDS YP_002388752.1 218555839 7128093 complement(3511078..3511896) 1 NC_011741.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 3511896 aroE 7128093 aroE Escherichia coli IAI1 shikimate 5-dehydrogenase YP_002388752.1 3511078 R 585034 CDS YP_002388753.1 218555840 7125806 complement(3511901..3512473) 1 NC_011741.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; putative ribosome maturation factor 3512473 yrdC 7125806 yrdC Escherichia coli IAI1 putative ribosome maturation factor YP_002388753.1 3511901 R 585034 CDS YP_002388754.1 218555841 7128094 complement(3512478..3513020) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative DNA topoisomerase 3513020 yrdD 7128094 yrdD Escherichia coli IAI1 putative DNA topoisomerase YP_002388754.1 3512478 R 585034 CDS YP_002388755.1 218555842 7128095 complement(3513049..3513522) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8432722; hypothetical protein 3513522 smg 7128095 smg Escherichia coli IAI1 hypothetical protein YP_002388755.1 3513049 R 585034 CDS YP_002388756.1 218555843 7127937 complement(3513494..3514618) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8112305, 8432722; DNA protecting protein DprA 3514618 smf 7127937 smf Escherichia coli IAI1 DNA protecting protein DprA YP_002388756.1 3513494 R 585034 CDS YP_002388757.1 218555844 7127936 3514748..3515257 1 NC_011741.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 3515257 def 7127936 def Escherichia coli IAI1 peptide deformylase YP_002388757.1 3514748 D 585034 CDS YP_002388758.1 218555845 7124559 3515272..3516219 1 NC_011741.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 3516219 fmt 7124559 fmt Escherichia coli IAI1 methionyl-tRNA formyltransferase YP_002388758.1 3515272 D 585034 CDS YP_002388759.1 218555846 7127254 3516265..3517554 1 NC_011741.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase B 3517554 rsmB 7127254 rsmB Escherichia coli IAI1 16S rRNA methyltransferase B YP_002388759.1 3516265 D 585034 CDS YP_002388760.1 218555847 7128437 3517576..3518952 1 NC_011741.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 3518952 trkA 7128437 trkA Escherichia coli IAI1 potassium transporter peripheral membrane component YP_002388760.1 3517576 D 585034 CDS YP_002388761.1 218555848 7127485 3519082..3519492 1 NC_011741.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 3519492 mscL 7127485 mscL Escherichia coli IAI1 large-conductance mechanosensitive channel YP_002388761.1 3519082 D 585034 CDS YP_002388762.1 218555849 7124479 complement(3519489..3519707) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3519707 yhdL 7124479 yhdL Escherichia coli IAI1 hypothetical protein YP_002388762.1 3519489 R 585034 CDS YP_002388763.1 218555850 7128769 complement(3519763..3520188) 1 NC_011741.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator 3520188 zntR 7128769 zntR Escherichia coli IAI1 zinc-responsive transcriptional regulator YP_002388763.1 3519763 R 585034 CDS YP_002388764.1 218555851 7128127 complement(3520199..3520567) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3520567 yhdN 7128127 yhdN Escherichia coli IAI1 hypothetical protein YP_002388764.1 3520199 R 585034 CDS YP_002388765.1 218555852 7128770 complement(3520674..3521057) 1 NC_011741.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 3521057 rplQ 7128770 rplQ Escherichia coli IAI1 50S ribosomal protein L17 YP_002388765.1 3520674 R 585034 CDS YP_002388766.1 218555853 7128378 complement(3521098..3522087) 1 NC_011741.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 3522087 rpoA 7128378 rpoA Escherichia coli IAI1 DNA-directed RNA polymerase subunit alpha YP_002388766.1 3521098 R 585034 CDS YP_002388767.1 218555854 7128396 complement(3522113..3522733) 1 NC_011741.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 3522733 rpsD 7128396 rpsD Escherichia coli IAI1 30S ribosomal protein S4 YP_002388767.1 3522113 R 585034 CDS YP_002388768.1 218555855 7128410 complement(3522767..3523156) 1 NC_011741.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 3523156 rpsK 7128410 rpsK Escherichia coli IAI1 30S ribosomal protein S11 YP_002388768.1 3522767 R 585034 CDS YP_002388769.1 218555856 7128417 complement(3523173..3523529) 1 NC_011741.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 3523529 rpsM 7128417 rpsM Escherichia coli IAI1 30S ribosomal protein S13 YP_002388769.1 3523173 R 585034 CDS YP_002388770.1 218555857 7125503 complement(3523824..3525155) 1 NC_011741.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 3525155 secY 7125503 secY Escherichia coli IAI1 preprotein translocase subunit SecY YP_002388770.1 3523824 R 585034 CDS YP_002388771.1 218555858 7124698 complement(3525163..3525597) 1 NC_011741.1 late assembly protein; 50S ribosomal protein L15 3525597 rplO 7124698 rplO Escherichia coli IAI1 50S ribosomal protein L15 YP_002388771.1 3525163 R 585034 CDS YP_002388772.1 218555859 7128376 complement(3525601..3525780) 1 NC_011741.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 3525780 rpmD 7128376 rpmD Escherichia coli IAI1 50S ribosomal protein L30 YP_002388772.1 3525601 R 585034 CDS YP_002388773.1 218555860 7128390 complement(3525784..3526287) 1 NC_011741.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 3526287 rpsE 7128390 rpsE Escherichia coli IAI1 30S ribosomal protein S5 YP_002388773.1 3525784 R 585034 CDS YP_002388774.1 218555861 7128411 complement(3526302..3526655) 1 NC_011741.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 3526655 rplR 7128411 rplR Escherichia coli IAI1 50S ribosomal protein L18 YP_002388774.1 3526302 R 585034 CDS YP_002388775.1 218555862 7128379 complement(3526665..3527198) 1 NC_011741.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 3527198 rplF 7128379 rplF Escherichia coli IAI1 50S ribosomal protein L6 YP_002388775.1 3526665 R 585034 CDS YP_002388776.1 218555863 7128369 complement(3527211..3527603) 1 NC_011741.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 3527603 rpsH 7128369 rpsH Escherichia coli IAI1 30S ribosomal protein S8 YP_002388776.1 3527211 R 585034 CDS YP_002388777.1 218555864 7128414 complement(3527637..3527942) 1 NC_011741.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 3527942 rpsN 7128414 rpsN Escherichia coli IAI1 30S ribosomal protein S14 YP_002388777.1 3527637 R 585034 CDS YP_002388778.1 218555865 7128420 complement(3527957..3528496) 1 NC_011741.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 3528496 rplE 7128420 rplE Escherichia coli IAI1 50S ribosomal protein L5 YP_002388778.1 3527957 R 585034 CDS YP_002388779.1 218555866 7125107 complement(3528511..3528825) 1 NC_011741.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 3528825 rplX 7125107 rplX Escherichia coli IAI1 50S ribosomal protein L24 YP_002388779.1 3528511 R 585034 CDS YP_002388780.1 218555867 7128385 complement(3528836..3529207) 1 NC_011741.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 3529207 rplN 7128385 rplN Escherichia coli IAI1 50S ribosomal protein L14 YP_002388780.1 3528836 R 585034 CDS YP_002388781.1 218555868 7128375 complement(3529372..3529626) 1 NC_011741.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 3529626 rpsQ 7128375 rpsQ Escherichia coli IAI1 30S ribosomal protein S17 YP_002388781.1 3529372 R 585034 CDS YP_002388782.1 218555869 7128423 complement(3529626..3529817) 1 NC_011741.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 3529817 rpmC 7128423 rpmC Escherichia coli IAI1 50S ribosomal protein L29 YP_002388782.1 3529626 R 585034 CDS YP_002388783.1 218555870 7128389 complement(3529817..3530227) 1 NC_011741.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 3530227 rplP 7128389 rplP Escherichia coli IAI1 50S ribosomal protein L16 YP_002388783.1 3529817 R 585034 CDS YP_002388784.1 218555871 7128377 complement(3530240..3530941) 1 NC_011741.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 3530941 rpsC 7128377 rpsC Escherichia coli IAI1 30S ribosomal protein S3 YP_002388784.1 3530240 R 585034 CDS YP_002388785.1 218555872 7128409 complement(3530959..3531291) 1 NC_011741.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 3531291 rplV 7128409 rplV Escherichia coli IAI1 50S ribosomal protein L22 YP_002388785.1 3530959 R 585034 CDS YP_002388786.1 218555873 7128383 complement(3531306..3531584) 1 NC_011741.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 3531584 rpsS 7128383 rpsS Escherichia coli IAI1 30S ribosomal protein S19 YP_002388786.1 3531306 R 585034 CDS YP_002388787.1 218555874 7128425 complement(3531601..3532422) 1 NC_011741.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 3532422 rplB 7128425 rplB Escherichia coli IAI1 50S ribosomal protein L2 YP_002388787.1 3531601 R 585034 CDS YP_002388788.1 218555875 7128619 complement(3532440..3532742) 1 NC_011741.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 3532742 rplW 7128619 rplW Escherichia coli IAI1 50S ribosomal protein L23 YP_002388788.1 3532440 R 585034 CDS YP_002388789.1 218555876 7128384 complement(3532739..3533344) 1 NC_011741.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 3533344 rplD 7128384 rplD Escherichia coli IAI1 50S ribosomal protein L4 YP_002388789.1 3532739 R 585034 CDS YP_002388790.1 218555877 7128621 complement(3533355..3533984) 1 NC_011741.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 3533984 rplC 7128621 rplC Escherichia coli IAI1 50S ribosomal protein L3 YP_002388790.1 3533355 R 585034 CDS YP_002388791.1 218555878 7128620 complement(3534017..3534328) 1 NC_011741.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 3534328 rpsJ 7128620 rpsJ Escherichia coli IAI1 30S ribosomal protein S10 YP_002388791.1 3534017 R 585034 CDS YP_002388792.1 218555879 7128416 complement(3534457..3534618) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 3534618 7128416 ECIAI1_3471 Escherichia coli IAI1 hypothetical protein YP_002388792.1 3534457 R 585034 CDS YP_002388793.1 218555880 7125606 3534707..3535174 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative bifunctional prepilin peptidase HopD: leader peptidase; methyl transferase 3535174 7125606 ECIAI1_3472 Escherichia coli IAI1 putative bifunctional prepilin peptidase HopD: leader peptidase; methyl transferase YP_002388793.1 3534707 D 585034 CDS YP_002388794.1 218555881 7125607 complement(3535171..3535647) 1 NC_011741.1 iron storage protein; bacterioferritin 3535647 bfr 7125607 bfr Escherichia coli IAI1 bacterioferritin YP_002388794.1 3535171 R 585034 CDS YP_002388795.1 218555882 7124399 complement(3535720..3535914) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8954950, 9889981, 2661540, 8639572; Product type c : carrier; bacterioferritin-associated ferredoxin 3535914 bfd 7124399 bfd Escherichia coli IAI1 bacterioferritin-associated ferredoxin YP_002388795.1 3535720 R 585034 CDS YP_002388796.1 218555883 7124398 complement(3536097..3537281) 1 NC_011741.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 3537281 tufA 7124398 tufA Escherichia coli IAI1 elongation factor Tu YP_002388796.1 3536097 R 585034 CDS YP_002388797.1 218555884 7127516 complement(3537352..3539466) 1 NC_011741.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 3539466 fusA 7127516 fusA Escherichia coli IAI1 elongation factor G YP_002388797.1 3537352 R 585034 CDS YP_002388798.1 218555885 7128256 complement(3539563..3540033) 1 NC_011741.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 3540033 rpsG 7128256 rpsG Escherichia coli IAI1 30S ribosomal protein S7 YP_002388798.1 3539563 R 585034 CDS YP_002388799.1 218555886 7128413 complement(3540130..3540504) 1 NC_011741.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 3540504 rpsL 7128413 rpsL Escherichia coli IAI1 30S ribosomal protein S12 YP_002388799.1 3540130 R 585034 CDS YP_002388800.1 218555887 7128418 complement(3540630..3540917) 1 NC_011741.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB 3540917 tusB 7128418 tusB Escherichia coli IAI1 sulfur transfer complex subunit TusB YP_002388800.1 3540630 R 585034 CDS YP_002388801.1 218555888 7127520 complement(3540925..3541284) 1 NC_011741.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC 3541284 tusC 7127520 tusC Escherichia coli IAI1 sulfur relay protein TusC YP_002388801.1 3540925 R 585034 CDS YP_002388802.1 218555889 7127521 complement(3541284..3541670) 1 NC_011741.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 3541670 tusD 7127521 tusD Escherichia coli IAI1 sulfur transfer complex subunit TusD YP_002388802.1 3541284 R 585034 CDS YP_002388803.1 218555890 7127522 complement(3541670..3542392) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3542392 yheO 7127522 yheO Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002388803.1 3541670 R 585034 CDS YP_002388804.1 218555891 7128775 complement(3542559..3543371) 1 NC_011741.1 rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase 3543371 fkpA 7128775 fkpA Escherichia coli IAI1 FKBP-type peptidyl-prolyl cis-trans isomerase YP_002388804.1 3542559 R 585034 CDS YP_002388805.1 218555892 7127207 3543592..3543810 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3543810 slyX 7127207 slyX Escherichia coli IAI1 hypothetical protein YP_002388805.1 3543592 D 585034 CDS YP_002388806.1 218555893 7127935 complement(3543859..3544449) 1 NC_011741.1 rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase 3544449 slyD 7127935 slyD Escherichia coli IAI1 FKBP-type peptidyl-prolyl cis-trans isomerase YP_002388806.1 3543859 R 585034 CDS YP_002388807.1 218555894 7127934 complement(3544544..3544744) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3544744 yheV 7127934 yheV Escherichia coli IAI1 hypothetical protein YP_002388807.1 3544544 R 585034 CDS YP_002388808.1 218555895 7128779 complement(3544754..3546559) 1 NC_011741.1 involved in potassium efflux; glutathione-regulated potassium-efflux system protein KefB 3546559 kefB 7128779 kefB Escherichia coli IAI1 glutathione-regulated potassium-efflux system protein KefB YP_002388808.1 3544754 R 585034 CDS YP_002388809.1 218555896 7126386 complement(3546559..3547113) 1 NC_011741.1 required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG 3547113 kefG 7126386 kefG Escherichia coli IAI1 glutathione-regulated potassium-efflux system ancillary protein KefG YP_002388809.1 3546559 R 585034 CDS YP_002388810.1 218555897 7126389 3547241..3549154 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 3549154 yheS 7126389 yheS Escherichia coli IAI1 putative ABC transporter ATP-binding protein YP_002388810.1 3547241 D 585034 CDS YP_002388811.1 218555898 7128776 3549154..3550176 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9889164; Product type pe : putative enzyme; putative hydrolase 3550176 yheT 7128776 yheT Escherichia coli IAI1 putative hydrolase YP_002388811.1 3549154 D 585034 CDS YP_002388812.1 218555899 7128777 3550170..3550388 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3550388 yheU 7128777 yheU Escherichia coli IAI1 hypothetical protein YP_002388812.1 3550170 D 585034 CDS YP_002388813.1 218555900 7128778 3550442..3551311 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2559876; Product type e : enzyme; phosphoribulokinase 3551311 prkB 7128778 prkB Escherichia coli IAI1 phosphoribulokinase YP_002388813.1 3550442 D 585034 CDS YP_002388814.1 218555901 7126151 complement(3551366..3551770) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3551770 yhfA 7126151 yhfA Escherichia coli IAI1 hypothetical protein YP_002388814.1 3551366 R 585034 CDS YP_002388815.1 218555902 7125915 3551850..3552065 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3552065 7125915 ECIAI1_3495 Escherichia coli IAI1 hypothetical protein YP_002388815.1 3551850 D 585034 CDS YP_002388816.1 218555903 7125608 3552072..3552704 1 NC_011741.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 3552704 crp 7125608 crp Escherichia coli IAI1 cAMP-regulatory protein YP_002388816.1 3552072 D 585034 CDS YP_002388817.1 218555904 7125914 3552743..3554845 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3554845 yhfK 7125914 yhfK Escherichia coli IAI1 hypothetical protein YP_002388817.1 3552743 D 585034 CDS YP_002388818.1 218555905 7128782 complement(3554912..3556132) 1 NC_011741.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein 3556132 argD 7128782 argD Escherichia coli IAI1 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein YP_002388818.1 3554912 R 585034 CDS YP_002388819.1 218555906 7125789 complement(3556218..3556781) 1 NC_011741.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 3556781 pabA 7125789 pabA Escherichia coli IAI1 para-aminobenzoate synthase component II YP_002388819.1 3556218 R 585034 CDS YP_002388820.1 218555907 7125428 complement(3556813..3557415) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92021789, 94095125, 2007139, 2403545, 2546924, 7549107; Product type cp : cell process; cell filamentation protein Fic 3557415 fic 7125428 fic Escherichia coli IAI1 cell filamentation protein Fic YP_002388820.1 3556813 R 585034 CDS YP_002388821.1 218555908 7127106 complement(3557405..3557572) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3557572 yhfG 7127106 yhfG Escherichia coli IAI1 hypothetical protein YP_002388821.1 3557405 R 585034 CDS YP_002388822.1 218555909 7128781 complement(3557677..3558249) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90272647, 91175755, 1606970, 2001362, 2007139, 2190212, 2403545, 2546924, 8130188, 8180197; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase A 3558249 ppiA 7128781 ppiA Escherichia coli IAI1 peptidyl-prolyl cis-trans isomerase A YP_002388822.1 3557677 R 585034 CDS YP_002388823.1 218555910 7126132 3558520..3559701 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20509826; Product type pt : putative transporter; hypothetical protein 3559701 tsgA 7126132 tsgA Escherichia coli IAI1 hypothetical protein YP_002388823.1 3558520 D 585034 CDS YP_002388824.1 218555911 7127510 3559963..3562506 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93062014, 2200672, 2445993, 2543955; Product type e : enzyme; nitrite reductase, large subunit 3562506 nirB 7127510 nirB Escherichia coli IAI1 nitrite reductase, large subunit YP_002388824.1 3559963 D 585034 CDS YP_002388825.1 218555912 7127884 3562503..3562829 1 NC_011741.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 3562829 nirD 7127884 nirD Escherichia coli IAI1 nitrite reductase small subunit YP_002388825.1 3562503 D 585034 CDS YP_002388826.1 218555913 7127886 3562956..3563762 1 NC_011741.1 member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 3563762 nirC 7127886 nirC Escherichia coli IAI1 nitrite transporter NirC YP_002388826.1 3562956 D 585034 CDS YP_002388827.1 218555914 7127885 3563781..3565154 1 NC_011741.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 3565154 cysG 7127885 cysG Escherichia coli IAI1 siroheme synthase YP_002388827.1 3563781 D 585034 CDS YP_002388828.1 218555915 7126892 3565401..3565568 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3565568 yhfL 7126892 yhfL Escherichia coli IAI1 hypothetical protein YP_002388828.1 3565401 D 585034 CDS YP_002388829.1 218555916 7127045 3565863..3567200 1 NC_011741.1 inner membrane protein possibly involved in fructoselysine transport; member of the flr operon; putative fructoselysine transporter 3567200 frlA 7127045 frlA Escherichia coli IAI1 putative fructoselysine transporter YP_002388829.1 3565863 D 585034 CDS YP_002388830.1 218555917 7127275 3567221..3568243 1 NC_011741.1 catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine; fructoselysine-6-P-deglycase 3568243 frlB 7127275 frlB Escherichia coli IAI1 fructoselysine-6-P-deglycase YP_002388830.1 3567221 D 585034 CDS YP_002388831.1 218555918 7127276 3568293..3569123 1 NC_011741.1 YhfOP; YhfP; YhfO; FrlC; catalyzes the interconversion of fructoselysine and psicoselysine; fructoselysine 3-epimerase 3569123 frlC 7127276 frlC Escherichia coli IAI1 fructoselysine 3-epimerase YP_002388831.1 3568293 D 585034 CDS YP_002388832.1 218555919 7127277 3569120..3569905 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12147680; Product type e : enzyme; fructoselysine 6-kinase 3569905 frlD 7127277 frlD Escherichia coli IAI1 fructoselysine 6-kinase YP_002388832.1 3569120 D 585034 CDS YP_002388833.1 218555920 7127278 3570005..3570736 1 NC_011741.1 may act as a transcriptional regulator of a putative fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes; DNA-binding transcriptional regulator FrlR 3570736 frlR 7127278 frlR Escherichia coli IAI1 DNA-binding transcriptional regulator FrlR YP_002388833.1 3570005 D 585034 CDS YP_002388834.1 218555921 7127279 complement(3570888..3571973) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3571973 yhfS 7127279 yhfS Escherichia coli IAI1 hypothetical protein YP_002388834.1 3570888 R 585034 CDS YP_002388835.1 218555922 7127126 complement(3571985..3573289) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3573289 yhfT 7127126 yhfT Escherichia coli IAI1 hypothetical protein YP_002388835.1 3571985 R 585034 CDS YP_002388836.1 218555923 7127127 complement(3573301..3573654) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3573654 yhfU 7127127 yhfU Escherichia coli IAI1 hypothetical protein YP_002388836.1 3573301 R 585034 CDS YP_002388837.1 218555924 7127128 complement(3573665..3574543) 1 NC_011741.1 phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE); putative hydrolase 3574543 php 7127128 php Escherichia coli IAI1 putative hydrolase YP_002388837.1 3573665 R 585034 CDS YP_002388838.1 218555925 7124222 complement(3574540..3575766) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative mutase 3575766 yhfW 7124222 yhfW Escherichia coli IAI1 putative mutase YP_002388838.1 3574540 R 585034 CDS YP_002388839.1 218555926 7127129 complement(3575766..3576929) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amino acid racemase 3576929 yhfX 7127129 yhfX Escherichia coli IAI1 putative amino acid racemase YP_002388839.1 3575766 R 585034 CDS YP_002388840.1 218555927 7127130 complement(3577013..3577375) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3577375 yhfY 7127130 yhfY Escherichia coli IAI1 hypothetical protein YP_002388840.1 3577013 R 585034 CDS YP_002388841.1 218555928 7127131 complement(3577392..3578297) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3578297 yhfZ 7127131 yhfZ Escherichia coli IAI1 hypothetical protein YP_002388841.1 3577392 R 585034 CDS YP_002388842.1 218555929 7127132 complement(3578566..3579570) 1 NC_011741.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 3579570 trpS 7127132 trpS Escherichia coli IAI1 tryptophanyl-tRNA synthetase YP_002388842.1 3578566 R 585034 CDS YP_002388843.1 218555930 7127501 complement(3579563..3580321) 1 NC_011741.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 3580321 gph 7127501 gph Escherichia coli IAI1 phosphoglycolate phosphatase YP_002388843.1 3579563 R 585034 CDS YP_002388844.1 218555931 7128457 complement(3580314..3580991) 1 NC_011741.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 3580991 rpe 7128457 rpe Escherichia coli IAI1 ribulose-phosphate 3-epimerase YP_002388844.1 3580314 R 585034 CDS YP_002388845.1 218555932 7128615 complement(3581009..3581845) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90136529, 92262475, 92272672, 2549371, 6300769, 7603433, 8341592; Product type e : enzyme; DNA adenine methylase 3581845 dam 7128615 dam Escherichia coli IAI1 DNA adenine methylase YP_002388845.1 3581009 R 585034 CDS YP_002388846.1 218555933 7126914 complement(3581952..3583238) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3583238 damX 7126914 damX Escherichia coli IAI1 hypothetical protein YP_002388846.1 3581952 R 585034 CDS YP_002388847.1 218555934 7126915 complement(3583330..3584418) 1 NC_011741.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 3584418 aroB 7126915 aroB Escherichia coli IAI1 3-dehydroquinate synthase YP_002388847.1 3583330 R 585034 CDS YP_002388848.1 218555935 7125803 complement(3584475..3584996) 1 NC_011741.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 3584996 aroK 7125803 aroK Escherichia coli IAI1 shikimate kinase I YP_002388848.1 3584475 R 585034 CDS YP_002388849.1 218555936 7125810 complement(3585397..3586635) 1 NC_011741.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; outer membrane porin HofQ 3586635 hofQ 7125810 hofQ Escherichia coli IAI1 outer membrane porin HofQ YP_002388849.1 3585397 R 585034 CDS YP_002388850.1 218555937 7125289 complement(3586547..3586951) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3586951 yrfA 7125289 yrfA Escherichia coli IAI1 hypothetical protein YP_002388850.1 3586547 R 585034 CDS YP_002388851.1 218555938 7128096 complement(3586941..3587381) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3587381 yrfB 7128096 yrfB Escherichia coli IAI1 hypothetical protein YP_002388851.1 3586941 R 585034 CDS YP_002388852.1 218555939 7128097 complement(3587365..3587904) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial assembly protein 3587904 yrfC 7128097 yrfC Escherichia coli IAI1 putative fimbrial assembly protein YP_002388852.1 3587365 R 585034 CDS YP_002388853.1 218555940 7128098 complement(3587904..3588683) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative pilus assembly protein 3588683 yrfD 7128098 yrfD Escherichia coli IAI1 putative pilus assembly protein YP_002388853.1 3587904 R 585034 CDS YP_002388854.1 218555941 7128099 3588803..3591355 1 NC_011741.1 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 3591355 mrcA 7128099 mrcA Escherichia coli IAI1 peptidoglycan synthetase YP_002388854.1 3588803 D 585034 CDS YP_002388855.1 218555942 7124470 complement(3591520..3592080) 1 NC_011741.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE 3592080 nudE 7124470 nudE Escherichia coli IAI1 ADP-ribose diphosphatase NudE YP_002388855.1 3591520 R 585034 CDS YP_002388856.1 218555943 7125954 3592400..3594535 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11553591; Product type r : regulator; intracellular growth attenuator protein 3594535 igaA 7125954 igaA Escherichia coli IAI1 intracellular growth attenuator protein YP_002388856.1 3592400 D 585034 CDS YP_002388857.1 218555944 7126046 3594600..3595268 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 3595268 yrfG 7126046 yrfG Escherichia coli IAI1 putative hydrolase YP_002388857.1 3594600 D 585034 CDS YP_002388858.1 218555945 7128100 3595279..3595680 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9867837, 10675343, 10675344; Product type f : factor; ribosome-associated heat shock protein Hsp15 3595680 hslR 7128100 hslR Escherichia coli IAI1 ribosome-associated heat shock protein Hsp15 YP_002388858.1 3595279 D 585034 CDS YP_002388859.1 218555946 7125314 3595705..3596583 1 NC_011741.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 3596583 hslO 7125314 hslO Escherichia coli IAI1 Hsp33-like chaperonin YP_002388859.1 3595705 D 585034 CDS YP_002388860.1 218555947 7125313 complement(3596646..3598370) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 20223645; Product type pm : putative membrane component; hypothetical protein 3598370 yhgE 7125313 yhgE Escherichia coli IAI1 hypothetical protein YP_002388860.1 3596646 R 585034 CDS YP_002388861.1 218555948 7127134 complement(3598376..3598522) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3598522 7127134 ECIAI1_3542 Escherichia coli IAI1 hypothetical protein YP_002388861.1 3598376 R 585034 CDS YP_002388862.1 218555949 7125609 complement(3598446..3598577) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 3598577 7125609 ECIAI1_3543 Escherichia coli IAI1 hypothetical protein YP_002388862.1 3598446 R 585034 CDS YP_002388863.1 218555950 7125610 3598749..3600371 1 NC_011741.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 3600371 pck 7125610 pck Escherichia coli IAI1 phosphoenolpyruvate carboxykinase YP_002388863.1 3598749 D 585034 CDS YP_002388864.1 218555951 7124159 3600488..3600805 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3600805 7124159 ECIAI1_3545 Escherichia coli IAI1 hypothetical protein YP_002388864.1 3600488 D 585034 CDS YP_002388865.1 218555952 7125611 3600864..3601160 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2404279; Product type pr : putative regulator; putative HTH-type transcriptional regulator yiaG 3601160 7125611 ECIAI1_3546 Escherichia coli IAI1 putative HTH-type transcriptional regulator yiaG YP_002388865.1 3600864 D 585034 CDS YP_002388866.1 218555953 7125612 complement(3601192..3602544) 1 NC_011741.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein 3602544 envZ 7125612 envZ Escherichia coli IAI1 osmolarity sensor protein YP_002388866.1 3601192 R 585034 CDS YP_002388867.1 218555954 7125077 complement(3602541..3603260) 1 NC_011741.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator 3603260 ompR 7125077 ompR Escherichia coli IAI1 osmolarity response regulator YP_002388867.1 3602541 R 585034 CDS YP_002388868.1 218555955 7125984 3603488..3603964 1 NC_011741.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 3603964 greB 7125984 greB Escherichia coli IAI1 transcription elongation factor GreB YP_002388868.1 3603488 D 585034 CDS YP_002388869.1 218555956 7128464 3604061..3606382 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8755871; Product type f : factor; transcriptional accessory protein 3606382 yhgF 7128464 yhgF Escherichia coli IAI1 transcriptional accessory protein YP_002388869.1 3604061 D 585034 CDS YP_002388870.1 218555957 7127135 3606839..3607066 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012482, 8407793; Product type t : transporter; ferrous iron transport protein A 3607066 feoA 7127135 feoA Escherichia coli IAI1 ferrous iron transport protein A YP_002388870.1 3606839 D 585034 CDS YP_002388871.1 218555958 7127085 3607083..3609404 1 NC_011741.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 3609404 feoB 7127085 feoB Escherichia coli IAI1 ferrous iron transport protein B YP_002388871.1 3607083 D 585034 CDS YP_002388872.1 218555959 7127086 3609404..3609640 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3609640 yhgG 7127086 yhgG Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002388872.1 3609404 D 585034 CDS YP_002388873.1 218555960 7127136 3609843..3610721 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2678009; Product type ph : phenotype; hypothetical protein 3610721 yhgA 7127136 yhgA Escherichia coli IAI1 hypothetical protein YP_002388873.1 3609843 D 585034 CDS YP_002388874.1 218555961 7127133 complement(3610750..3611520) 1 NC_011741.1 Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH 3611520 bioH 7127133 bioH Escherichia coli IAI1 carboxylesterase BioH YP_002388874.1 3610750 R 585034 CDS YP_002388875.1 218555962 7124412 3611558..3612241 1 NC_011741.1 involved in high-affinity gluconate transport; gluconate periplasmic binding protein 3612241 gntX 7124412 gntX Escherichia coli IAI1 gluconate periplasmic binding protein YP_002388875.1 3611558 D 585034 CDS YP_002388876.1 218555963 7128454 3612300..3612875 1 NC_011741.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; putative DNA uptake protein 3612875 gntY 7128454 gntY Escherichia coli IAI1 putative DNA uptake protein YP_002388876.1 3612300 D 585034 CDS YP_002388877.1 218555964 7128455 3613236..3614552 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 4574689, 4582156, 93139975, 97141270, 98019089, 2845225, 3040894, 7984428, 9045817; Product type t : transporter; gluconate transporter, high-affinity GNT I system 3614552 gntT 7128455 gntT Escherichia coli IAI1 gluconate transporter, high-affinity GNT I system YP_002388877.1 3613236 D 585034 CDS YP_002388878.1 218555965 7128452 complement(3614597..3616681) 1 NC_011741.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 3616681 malQ 7128452 malQ Escherichia coli IAI1 4-alpha-glucanotransferase YP_002388878.1 3614597 R 585034 CDS YP_002388879.1 218555966 7127661 complement(3616691..3619084) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89033892, 10220320, 10469642, 2845225, 3037809, 3155826, 6283313, 6339728, 6986282, 9009262; Product type e : enzyme; maltodextrin phosphorylase 3619084 malP 7127661 malP Escherichia coli IAI1 maltodextrin phosphorylase YP_002388879.1 3616691 R 585034 CDS YP_002388880.1 218555967 7127660 3619696..3622401 1 NC_011741.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 3622401 malT 7127660 malT Escherichia coli IAI1 transcriptional regulator MalT YP_002388880.1 3619696 D 585034 CDS YP_002388881.1 218555968 7127663 complement(3622444..3623460) 1 NC_011741.1 catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase 3623460 rtcA 7127663 rtcA Escherichia coli IAI1 RNA 3'-terminal-phosphate cyclase YP_002388881.1 3622444 R 585034 CDS YP_002388882.1 218555969 7124628 complement(3623464..3624690) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9738023; hypothetical protein 3624690 rtcB 7124628 rtcB Escherichia coli IAI1 hypothetical protein YP_002388882.1 3623464 R 585034 CDS YP_002388883.1 218555970 7124629 3624879..3626477 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9738023, 3045764, 7920643, 7984428; Product type r : regulator; sigma 54-dependent transcriptional regulator of rtcBA expression 3626477 rtcR 7124629 rtcR Escherichia coli IAI1 sigma 54-dependent transcriptional regulator of rtcBA expression YP_002388883.1 3624879 D 585034 CDS YP_002388884.1 218555971 7124630 complement(3626459..3627217) 1 NC_011741.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR 3627217 glpR 7124630 glpR Escherichia coli IAI1 DNA-binding transcriptional repressor GlpR YP_002388884.1 3626459 R 585034 CDS YP_002388885.1 218555972 7128343 complement(3627234..3628064) 1 NC_011741.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG 3628064 glpG 7128343 glpG Escherichia coli IAI1 intramembrane serine protease GlpG YP_002388885.1 3627234 R 585034 CDS YP_002388886.1 218555973 7128340 complement(3628109..3628435) 1 NC_011741.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase 3628435 glpE 7128340 glpE Escherichia coli IAI1 thiosulfate sulfurtransferase YP_002388886.1 3628109 R 585034 CDS YP_002388887.1 218555974 7128338 3628625..3630130 1 NC_011741.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 3630130 glpD 7128338 glpD Escherichia coli IAI1 glycerol-3-phosphate dehydrogenase YP_002388887.1 3628625 D 585034 CDS YP_002388888.1 218555975 7128337 complement(3630184..3630789) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3630789 7128337 ECIAI1_3570 Escherichia coli IAI1 hypothetical protein YP_002388888.1 3630184 R 585034 CDS YP_002388889.1 218555976 7125613 complement(3630792..3631559) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3631559 7125613 ECIAI1_3571 Escherichia coli IAI1 hypothetical protein YP_002388889.1 3630792 R 585034 CDS YP_002388890.1 218555977 7125614 complement(3631562..3632272) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3632272 7125614 ECIAI1_3572 Escherichia coli IAI1 hypothetical protein YP_002388890.1 3631562 R 585034 CDS YP_002388891.1 218555978 7125615 complement(3632287..3633804) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3633804 7125615 ECIAI1_3573 Escherichia coli IAI1 hypothetical protein YP_002388891.1 3632287 R 585034 CDS YP_002388892.1 218555979 7125616 complement(3633920..3636367) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88330897, 91104907, 91236706, 2645169, 2975249, 3047129, 3097003; Product type e : enzyme; glycogen phosphorylase 3636367 glgP 7125616 glgP Escherichia coli IAI1 glycogen phosphorylase YP_002388892.1 3633920 R 585034 CDS YP_002388893.1 218555980 7128314 complement(3636386..3637819) 1 NC_011741.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 3637819 glgA 7128314 glgA Escherichia coli IAI1 glycogen synthase YP_002388893.1 3636386 R 585034 CDS YP_002388894.1 218555981 7128311 complement(3637819..3639114) 1 NC_011741.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 3639114 glgC 7128311 glgC Escherichia coli IAI1 glucose-1-phosphate adenylyltransferase YP_002388894.1 3637819 R 585034 CDS YP_002388895.1 218555982 7128313 complement(3639132..3641105) 1 NC_011741.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching enzyme 3641105 glgX 7128313 glgX Escherichia coli IAI1 glycogen debranching enzyme YP_002388895.1 3639132 R 585034 CDS YP_002388896.1 218555983 7128316 complement(3641102..3643288) 1 NC_011741.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 3643288 glgB 7128316 glgB Escherichia coli IAI1 glycogen branching enzyme YP_002388896.1 3641102 R 585034 CDS YP_002388897.1 218555984 7128312 complement(3643561..3644664) 1 NC_011741.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 3644664 asd 7128312 asd Escherichia coli IAI1 aspartate-semialdehyde dehydrogenase YP_002388897.1 3643561 R 585034 CDS YP_002388898.1 218555985 7125828 3644856..3645449 1 NC_011741.1 YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); putative dITP- and XTP- hydrolase 3645449 yhgN 7125828 yhgN Escherichia coli IAI1 putative dITP- and XTP- hydrolase YP_002388898.1 3644856 D 585034 CDS YP_002388899.1 218555986 7127137 complement(3645506..3646846) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8655507, 9119199, 9135111, 97141270; Product type t : transporter; low affinity gluconate transporter 3646846 gntU 7127137 gntU Escherichia coli IAI1 low affinity gluconate transporter YP_002388899.1 3645506 R 585034 CDS YP_002388900.1 218555987 7128453 complement(3646850..3647377) 1 NC_011741.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase 1 3647377 gntK 7128453 gntK Escherichia coli IAI1 gluconate kinase 1 YP_002388900.1 3646850 R 585034 CDS YP_002388901.1 218555988 7128449 complement(3647516..3648511) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 9135111, 93139975, 9537375, 8655507; Product type r : regulator; DNA-binding transcriptional repressor 3648511 gntR 7128449 gntR Escherichia coli IAI1 DNA-binding transcriptional repressor YP_002388901.1 3647516 R 585034 CDS YP_002388902.1 218555989 7128451 complement(3648735..3649430) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3649430 yhhW 7128451 yhhW Escherichia coli IAI1 hypothetical protein YP_002388902.1 3648735 R 585034 CDS YP_002388903.1 218555990 7127155 complement(3649553..3650590) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10493123; Product type pe : putative enzyme; putative dehydrogenase 3650590 yhhX 7127155 yhhX Escherichia coli IAI1 putative dehydrogenase YP_002388903.1 3649553 R 585034 CDS YP_002388904.1 218555991 7124664 3650922..3651410 1 NC_011741.1 YhhY; regulated by the fur regulator; unknown function; putative acetyltransferase YhhY 3651410 yhhY 7124664 yhhY Escherichia coli IAI1 putative acetyltransferase YhhY YP_002388904.1 3650922 D 585034 CDS YP_002388905.1 218555992 7127157 3651647..3652825 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3652825 yhhZ 7127157 yhhZ Escherichia coli IAI1 hypothetical protein YP_002388905.1 3651647 D 585034 CDS YP_002388906.1 218555993 7127158 3652822..3653316 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3653316 yrhA 7127158 yrhA Escherichia coli IAI1 hypothetical protein YP_002388906.1 3652822 D 585034 CDS YP_002388907.1 218555994 7128101 3653402..3653566 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3653566 yrhD 7128101 yrhD Escherichia coli IAI1 hypothetical protein YP_002388907.1 3653402 D 585034 CDS YP_002388908.1 218555995 7128103 3653766..3654050 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3654050 yrhB 7128103 yrhB Escherichia coli IAI1 hypothetical protein YP_002388908.1 3653766 D 585034 CDS YP_002388909.1 218555996 7128102 complement(3654088..3655830) 1 NC_011741.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase 3655830 ggt 7128102 ggt Escherichia coli IAI1 gamma-glutamyltranspeptidase YP_002388909.1 3654088 R 585034 CDS YP_002388910.1 218555997 7128301 3655950..3656390 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3656390 yhhA 7128301 yhhA Escherichia coli IAI1 hypothetical protein YP_002388910.1 3655950 D 585034 CDS YP_002388911.1 218555998 7127138 complement(3656377..3657120) 1 NC_011741.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; cytoplasmic glycerophosphodiester phosphodiesterase 3657120 ugpQ 7127138 ugpQ Escherichia coli IAI1 cytoplasmic glycerophosphodiester phosphodiesterase YP_002388911.1 3656377 R 585034 CDS YP_002388912.1 218555999 7125526 complement(3657117..3658187) 1 NC_011741.1 part of the UgpABCE glycerol-3-phosphate uptake system; glycerol-3-phosphate transporter ATP-binding subunit 3658187 ugpC 7125526 ugpC Escherichia coli IAI1 glycerol-3-phosphate transporter ATP-binding subunit YP_002388912.1 3657117 R 585034 CDS YP_002388913.1 218556000 7125524 complement(3658189..3659034) 1 NC_011741.1 with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein 3659034 ugpE 7125524 ugpE Escherichia coli IAI1 glycerol-3-phosphate transporter membrane protein YP_002388913.1 3658189 R 585034 CDS YP_002388914.1 218556001 7125525 complement(3659031..3659918) 1 NC_011741.1 with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease 3659918 ugpA 7125525 ugpA Escherichia coli IAI1 glycerol-3-phosphate transporter permease YP_002388914.1 3659031 R 585034 CDS YP_002388915.1 218556002 7125522 complement(3660016..3661332) 1 NC_011741.1 with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein 3661332 ugpB 7125522 ugpB Escherichia coli IAI1 glycerol-3-phosphate transporter periplasmic binding protein YP_002388915.1 3660016 R 585034 CDS YP_002388916.1 218556003 7125523 complement(3661728..3662441) 1 NC_011741.1 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 3662441 livF 7125523 livF Escherichia coli IAI1 leucine/isoleucine/valine transporter ATP-binding subunit YP_002388916.1 3661728 R 585034 CDS YP_002388917.1 218556004 7126423 complement(3662443..3663210) 1 NC_011741.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 3663210 livG 7126423 livG Escherichia coli IAI1 leucine/isoleucine/valine transporter ATP-binding subunit YP_002388917.1 3662443 R 585034 CDS YP_002388918.1 218556005 7126424 complement(3663207..3664484) 1 NC_011741.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease subunit 3664484 livM 7126424 livM Escherichia coli IAI1 leucine/isoleucine/valine transporter permease subunit YP_002388918.1 3663207 R 585034 CDS YP_002388919.1 218556006 7126428 complement(3664481..3665407) 1 NC_011741.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid transporter permease subunit LivH 3665407 livH 7126428 livH Escherichia coli IAI1 branched-chain amino acid transporter permease subunit LivH YP_002388919.1 3664481 R 585034 CDS YP_002388920.1 218556007 7126425 complement(3665455..3666564) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702302, 90307651, 2195019, 2649683, 3891753, 4077929, 9298646, 9298646; Product type t : transporter; leucine ABC transporter periplasmic-binding protein 3666564 livK 7126425 livK Escherichia coli IAI1 leucine ABC transporter periplasmic-binding protein YP_002388920.1 3665455 R 585034 CDS YP_002388921.1 218556008 7126427 3666988..3667371 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3667371 yhhK 7126427 yhhK Escherichia coli IAI1 hypothetical protein YP_002388921.1 3666988 D 585034 CDS YP_002388922.1 218556009 7127149 complement(3667368..3667895) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3667895 7127149 ECIAI1_3604 Escherichia coli IAI1 hypothetical protein YP_002388922.1 3667368 R 585034 CDS YP_002388923.1 218556010 7125617 complement(3667902..3668168) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3668168 7125617 ECIAI1_3605 Escherichia coli IAI1 hypothetical protein YP_002388923.1 3667902 R 585034 CDS YP_002388924.1 218556011 7125618 complement(3668318..3669421) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702302, 90307651, 2195019, 2649682, 328304, 3891753, 4077929, 9298646, 10972807; Product type t : transporter; leucine/isoleucine/valine ABC transporter periplasmic-binding protein 3669421 livJ 7125618 livJ Escherichia coli IAI1 leucine/isoleucine/valine ABC transporter periplasmic-binding protein YP_002388924.1 3668318 R 585034 CDS YP_002388925.1 218556012 7126426 complement(3669692..3670546) 1 NC_011741.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 3670546 rpoH 7126426 rpoH Escherichia coli IAI1 RNA polymerase factor sigma-32 YP_002388925.1 3669692 R 585034 CDS YP_002388926.1 218556013 7128401 complement(3670791..3671849) 1 NC_011741.1 putative ABC transporter, membrane protein; cell division protein FtsX 3671849 ftsX 7128401 ftsX Escherichia coli IAI1 cell division protein FtsX YP_002388926.1 3670791 R 585034 CDS YP_002388927.1 218556014 7128242 complement(3671842..3672510) 1 NC_011741.1 putative ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE 3672510 ftsE 7128242 ftsE Escherichia coli IAI1 cell division protein FtsE YP_002388927.1 3671842 R 585034 CDS YP_002388928.1 218556015 7128234 complement(3672513..3674006) 1 NC_011741.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY 3674006 ftsY 7128234 ftsY Escherichia coli IAI1 cell division protein FtsY YP_002388928.1 3672513 R 585034 CDS YP_002388929.1 218556016 7128243 3674156..3674752 1 NC_011741.1 catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 3674752 rsmD 7128243 rsmD Escherichia coli IAI1 16S rRNA m(2)G966-methyltransferase YP_002388929.1 3674156 D 585034 CDS YP_002388930.1 218556017 7127139 3674619..3675011 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3675011 7127139 ECIAI1_3613 Escherichia coli IAI1 hypothetical protein YP_002388930.1 3674619 D 585034 CDS YP_002388931.1 218556018 7125619 complement(3675014..3675373) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3675373 yhhM 7125619 yhhM Escherichia coli IAI1 hypothetical protein YP_002388931.1 3675014 R 585034 CDS YP_002388932.1 218556019 7127150 3675514..3676140 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3676140 yhhN 7127150 yhhN Escherichia coli IAI1 hypothetical protein YP_002388932.1 3675514 D 585034 CDS YP_002388933.1 218556020 7127151 3676214..3678412 1 NC_011741.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 3678412 zntA 7127151 zntA Escherichia coli IAI1 zinc/cadmium/mercury/lead-transporting ATPase YP_002388933.1 3676214 D 585034 CDS YP_002388934.1 218556021 7128126 complement(3678514..3678759) 1 NC_011741.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 3678759 tusA 7128126 tusA Escherichia coli IAI1 sulfur transfer protein SirA YP_002388934.1 3678514 R 585034 CDS YP_002388935.1 218556022 7127519 3678980..3679645 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3679645 yhhQ 7127519 yhhQ Escherichia coli IAI1 hypothetical protein YP_002388935.1 3678980 D 585034 CDS YP_002388936.1 218556023 7127152 3679718..3680275 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12558182, 8752353; Product type t : transporter; hypothetical protein 3680275 dcrB 7127152 dcrB Escherichia coli IAI1 hypothetical protein YP_002388936.1 3679718 D 585034 CDS YP_002388937.1 218556024 7126925 complement(3680279..3681496) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; major facilitator superfamily transporter 3681496 yhhS 7126925 yhhS Escherichia coli IAI1 major facilitator superfamily transporter YP_002388937.1 3680279 R 585034 CDS YP_002388938.1 218556025 7127153 3681628..3682677 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3682677 yhhT 7127153 yhhT Escherichia coli IAI1 hypothetical protein YP_002388938.1 3681628 D 585034 CDS YP_002388939.1 218556026 7127154 3682732..3683319 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20092861, 10625633, 8939709; Product type e : enzyme; holo-(acyl carrier protein) synthase 2 3683319 acpT 7127154 acpT Escherichia coli IAI1 holo-(acyl carrier protein) synthase 2 YP_002388939.1 3682732 D 585034 CDS YP_002388940.1 218556027 7125705 3683430..3685004 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12960164, 7934931, 92077434, 7867647; Product type t : transporter; nickel ABC transporter periplasmic-binding protein 3685004 nikA 7125705 nikA Escherichia coli IAI1 nickel ABC transporter periplasmic-binding protein YP_002388940.1 3683430 D 585034 CDS YP_002388941.1 218556028 7127877 3685004..3685948 1 NC_011741.1 with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 3685948 nikB 7127877 nikB Escherichia coli IAI1 nickel transporter permease NikB YP_002388941.1 3685004 D 585034 CDS YP_002388942.1 218556029 7127878 3685945..3686778 1 NC_011741.1 with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 3686778 nikC 7127878 nikC Escherichia coli IAI1 nickel transporter permease NikC YP_002388942.1 3685945 D 585034 CDS YP_002388943.1 218556030 7127879 3686778..3687542 1 NC_011741.1 with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 3687542 nikD 7127879 nikD Escherichia coli IAI1 nickel transporter ATP-binding protein NikD YP_002388943.1 3686778 D 585034 CDS YP_002388944.1 218556031 7127880 3687539..3688345 1 NC_011741.1 with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 3688345 nikE 7127880 nikE Escherichia coli IAI1 nickel transporter ATP-binding protein NikE YP_002388944.1 3687539 D 585034 CDS YP_002388945.1 218556032 7127881 3688351..3688752 1 NC_011741.1 Inhibits transcription at high concentrations of nickel; nickel responsive regulator 3688752 nikR 7127881 nikR Escherichia coli IAI1 nickel responsive regulator YP_002388945.1 3688351 D 585034 CDS YP_002388946.1 218556033 7127882 complement(3688872..3689231) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3689231 7127882 ECIAI1_3629 Escherichia coli IAI1 hypothetical protein YP_002388946.1 3688872 R 585034 CDS YP_002388947.1 218556034 7125620 complement(3689562..3690686) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter membrane protein 3690686 yhhJ 7125620 yhhJ Escherichia coli IAI1 putative ABC transporter membrane protein YP_002388947.1 3689562 R 585034 CDS YP_002388948.1 218556035 7127148 complement(3690686..3693421) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20074572; Product type e : enzyme; ribosome-associated ATPase 3693421 rbbA 7127148 rbbA Escherichia coli IAI1 ribosome-associated ATPase YP_002388948.1 3690686 R 585034 CDS YP_002388949.1 218556036 7126589 complement(3693418..3694485) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative HlyD family secretion protein 3694485 yhiI 7126589 yhiI Escherichia coli IAI1 putative HlyD family secretion protein YP_002388949.1 3693418 R 585034 CDS YP_002388950.1 218556037 7127161 complement(3694851..3696473) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3696473 yhiJ 7127161 yhiJ Escherichia coli IAI1 hypothetical protein YP_002388950.1 3694851 R 585034 CDS YP_002388951.1 218556038 7127162 complement(3696735..3698324) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3698324 7127162 ECIAI1_3634 Escherichia coli IAI1 hypothetical protein YP_002388951.1 3696735 R 585034 CDS YP_002388952.1 218556039 7125621 3698708..3699760 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3699760 yhiM 7125621 yhiM Escherichia coli IAI1 hypothetical protein YP_002388952.1 3698708 D 585034 CDS YP_002388953.1 218556040 7127163 complement(3700076..3701278) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 3701278 yhiN 7127163 yhiN Escherichia coli IAI1 putative oxidoreductase YP_002388953.1 3700076 R 585034 CDS YP_002388954.1 218556041 7127164 3701510..3703009 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87014120; Product type t : transporter; phosphate transporter, low-affinity 3703009 pitA 7127164 pitA Escherichia coli IAI1 phosphate transporter, low-affinity YP_002388954.1 3701510 D 585034 CDS YP_002388955.1 218556042 7124226 complement(3703080..3703415) 1 NC_011741.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB 3703415 yhiO 7124226 yhiO Escherichia coli IAI1 universal stress protein UspB YP_002388955.1 3703080 R 585034 CDS YP_002388956.1 218556043 7127165 3703806..3704240 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 93086426, 93308072, 94203056, 10499297, 10652104, 10931298, 11157932, 1453957, 8506346, 8932299, 9298646, 9405142; Product type f : factor; universal stress global response regulator 3704240 uspA 7127165 uspA Escherichia coli IAI1 universal stress global response regulator YP_002388956.1 3703806 D 585034 CDS YP_002388957.1 218556044 7125550 3704558..3706027 1 NC_011741.1 member of the POT family of peptide transporters; probable proton-dependent peptide transporter function; inner membrane transporter YhiP 3706027 yhiP 7125550 yhiP Escherichia coli IAI1 inner membrane transporter YhiP YP_002388957.1 3704558 D 585034 CDS YP_002388958.1 218556045 7127166 complement(3706076..3706828) 1 NC_011741.1 predicted SAM-dependent methyltransferase; putative methyltransferase 3706828 yhiQ 7127166 yhiQ Escherichia coli IAI1 putative methyltransferase YP_002388958.1 3706076 R 585034 CDS YP_002388959.1 218556046 7127167 complement(3706836..3708878) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92394891, 1325967, 8366062; Product type e : enzyme; oligopeptidase A 3708878 prlC 7127167 prlC Escherichia coli IAI1 oligopeptidase A YP_002388959.1 3706836 R 585034 CDS YP_002388960.1 218556047 7126152 3709081..3709923 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11591672; Product type pe : putative enzyme; putative DNA (exogenous) processing protein 3709923 yhiR 7126152 yhiR Escherichia coli IAI1 putative DNA (exogenous) processing protein YP_002388960.1 3709081 D 585034 CDS YP_002388961.1 218556048 7127168 3709995..3711347 1 NC_011741.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 3711347 gor 7127168 gor Escherichia coli IAI1 glutathione reductase YP_002388961.1 3709995 D 585034 CDS YP_002388962.1 218556049 7128456 3711506..3711685 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 3711685 7128456 ECIAI1_3646 Escherichia coli IAI1 hypothetical protein YP_002388962.1 3711506 D 585034 CDS YP_002388963.1 218556050 7125622 3712224..3712577 1 NC_011741.1 regulates the expression of of the arsRBC involved in resistance to arsenic; DNA-binding transcriptional repressor ArsR 3712577 arsR 7125622 arsR Escherichia coli IAI1 DNA-binding transcriptional repressor ArsR YP_002388963.1 3712224 D 585034 CDS YP_002388964.1 218556051 7125819 3712631..3713920 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15004242, 95355341, 1535622, 7721697; Product type t : transporter; arsenite/antimonite transporter 3713920 arsB 7125819 arsB Escherichia coli IAI1 arsenite/antimonite transporter YP_002388964.1 3712631 D 585034 CDS YP_002388965.1 218556052 7125817 3713933..3714358 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95355341, 7721697; Product type e : enzyme; arsenate reductase 3714358 arsC 7125817 arsC Escherichia coli IAI1 arsenate reductase YP_002388965.1 3713933 D 585034 CDS YP_002388966.1 218556053 7125818 complement(3714492..3714851) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3714851 7125818 ECIAI1_3651 Escherichia coli IAI1 hypothetical protein YP_002388966.1 3714492 R 585034 CDS YP_002388967.1 218556054 7125623 3714883..3715896 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 3715896 7125623 ECIAI1_3652 Escherichia coli IAI1 hypothetical protein YP_002388967.1 3714883 D 585034 CDS YP_002388968.1 218556055 7125624 3716476..3717699 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3717699 7125624 ECIAI1_3653 Escherichia coli IAI1 hypothetical protein YP_002388968.1 3716476 D 585034 CDS YP_002388969.1 218556056 7125625 3717946..3718512 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293775, 8022277; Product type lp : lipoprotein; outer membrane lipoprotein 3718512 slp 7125625 slp Escherichia coli IAI1 outer membrane lipoprotein YP_002388969.1 3717946 D 585034 CDS YP_002388970.1 218556057 7127930 3718668..3719198 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8022277; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3719198 yhiF 7127930 yhiF Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002388970.1 3718668 D 585034 CDS YP_002388971.1 218556058 7127160 complement(3719240..3719887) 1 NC_011741.1 inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli; putative Mg(2+) transport ATPase 3719887 yhiD 7127160 yhiD Escherichia coli IAI1 putative Mg(2+) transport ATPase YP_002388971.1 3719240 R 585034 CDS YP_002388972.1 218556059 7127159 complement(3719951..3720277) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94064579, 8885264, 12071744, 8244952, 8455549, 9298646, 9868784; Product type pf : putative factor; acid-resistance protein 3720277 hdeB 7127159 hdeB Escherichia coli IAI1 acid-resistance protein YP_002388972.1 3719951 R 585034 CDS YP_002388973.1 218556060 7128500 complement(3720393..3720725) 1 NC_011741.1 inactive form; acid-resistance protein 3720725 hdeA 7128500 hdeA Escherichia coli IAI1 acid-resistance protein YP_002388973.1 3720393 R 585034 CDS YP_002388974.1 218556061 7128499 3720980..3721552 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94064579, 8244952, 8455549; Product type pm : putative membrane component; acid-resistance membrane protein 3721552 hdeD 7128499 hdeD Escherichia coli IAI1 acid-resistance membrane protein YP_002388974.1 3720980 D 585034 CDS YP_002388975.1 218556062 7128501 3722351..3722878 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12399493, 12940989, 14702398; Product type r : regulator; DNA-binding transcriptional activator 3722878 gadE 7128501 gadE Escherichia coli IAI1 DNA-binding transcriptional activator YP_002388975.1 3722351 D 585034 CDS YP_002388976.1 218556063 7128264 3723217..3724374 1 NC_011741.1 with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds; multidrug efflux system protein MdtE 3724374 mdtE 7128264 mdtE Escherichia coli IAI1 multidrug efflux system protein MdtE YP_002388976.1 3723217 D 585034 CDS YP_002388977.1 218556064 7127692 3724399..3727512 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803; Product type t : transporter; multidrug transporter, RpoS-dependent 3727512 mdtF 7127692 mdtF Escherichia coli IAI1 multidrug transporter, RpoS-dependent YP_002388977.1 3724399 D 585034 CDS YP_002388978.1 218556065 7127693 complement(3727875..3728603) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12446650; Product type r : regulator; DNA-binding transcriptional activator 3728603 gadW 7127693 gadW Escherichia coli IAI1 DNA-binding transcriptional activator YP_002388978.1 3727875 R 585034 CDS YP_002388979.1 218556066 7128267 complement(3728971..3729795) 1 NC_011741.1 regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX 3729795 gadX 7128267 gadX Escherichia coli IAI1 DNA-binding transcriptional regulator GadX YP_002388979.1 3728971 R 585034 CDS YP_002388980.1 218556067 7128266 complement(3730165..3731565) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92155241, 92394884, 99406302, 1522060, 1740158, 7764225, 9298646; Product type e : enzyme; glutamate decarboxylase A, PLP-dependent 3731565 gadA 7128266 gadA Escherichia coli IAI1 glutamate decarboxylase A, PLP-dependent YP_002388980.1 3730165 R 585034 CDS YP_002388981.1 218556068 7128261 complement(3731776..3733173) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8163487, 14563563; Product type e : enzyme; cytochrome C peroxidase (cpp-like) 3733173 yhjA 7128261 yhjA Escherichia coli IAI1 cytochrome C peroxidase (cpp-like) YP_002388981.1 3731776 R 585034 CDS YP_002388982.1 218556069 7127169 3733578..3735227 1 NC_011741.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 3735227 treF 7127169 treF Escherichia coli IAI1 trehalase YP_002388982.1 3733578 D 585034 CDS YP_002388983.1 218556070 7127482 complement(3735278..3735880) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding response regulator in two-component regulatory system 3735880 yhjB 7127482 yhjB Escherichia coli IAI1 putative DNA-binding response regulator in two-component regulatory system YP_002388983.1 3735278 R 585034 CDS YP_002388984.1 218556071 7127170 3736328..3737299 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3737299 yhjC 7127170 yhjC Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002388984.1 3736328 D 585034 CDS YP_002388985.1 218556072 7127171 3737348..3738361 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3738361 yhjD 7127171 yhjD Escherichia coli IAI1 hypothetical protein YP_002388985.1 3737348 D 585034 CDS YP_002388986.1 218556073 7127172 3738772..3740094 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3740094 yhjE 7127172 yhjE Escherichia coli IAI1 putative transporter YP_002388986.1 3738772 D 585034 CDS YP_002388987.1 218556074 7127173 complement(3740328..3742403) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane biogenesis protein 3742403 yhjG 7127173 yhjG Escherichia coli IAI1 putative outer membrane biogenesis protein YP_002388987.1 3740328 R 585034 CDS YP_002388988.1 218556075 7127174 complement(3742458..3743225) 1 NC_011741.1 in Escherichia coli this protein is involved in flagellar function; EAL domain-containing protein 3743225 yhjH 7127174 yhjH Escherichia coli IAI1 EAL domain-containing protein YP_002388988.1 3742458 R 585034 CDS YP_002388989.1 218556076 7127175 3743179..3743373 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 3743373 7127175 ECIAI1_3676 Escherichia coli IAI1 hypothetical protein YP_002388989.1 3743179 D 585034 CDS YP_002388990.1 218556077 7125626 3743457..3744386 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4359651, 13813474; Product type e : enzyme; ketodeoxygluconokinase 3744386 kdgK 7125626 kdgK Escherichia coli IAI1 ketodeoxygluconokinase YP_002388990.1 3743457 D 585034 CDS YP_002388991.1 218556078 7126370 complement(3744482..3745978) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pe : putative enzyme; putative zinc-dependent peptidase 3745978 yhjJ 7126370 yhjJ Escherichia coli IAI1 putative zinc-dependent peptidase YP_002388991.1 3744482 R 585034 CDS YP_002388992.1 218556079 7127176 complement(3746199..3747485) 1 NC_011741.1 involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA 3747485 dctA 7127176 dctA Escherichia coli IAI1 C4-dicarboxylate transporter DctA YP_002388992.1 3746199 R 585034 CDS YP_002388993.1 218556080 7126926 complement(3747668..3749617) 1 NC_011741.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a putative phosphodiesterase protein from E. coli; putative phosphodiesterase 3749617 yhjK 7126926 yhjK Escherichia coli IAI1 putative phosphodiesterase YP_002388993.1 3747668 R 585034 CDS YP_002388994.1 218556081 7127177 complement(3749738..3753211) 1 NC_011741.1 cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA; cellulose synthase subunit BcsC 3753211 bcsC 7127177 bcsC Escherichia coli IAI1 cellulose synthase subunit BcsC YP_002388994.1 3749738 R 585034 CDS YP_002388995.1 218556082 7124388 complement(3753193..3754299) 1 NC_011741.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase 3754299 bcsZ 7124388 bcsZ Escherichia coli IAI1 endo-1,4-D-glucanase YP_002388995.1 3753193 R 585034 CDS YP_002388996.1 218556083 7124392 complement(3754306..3756645) 1 NC_011741.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein 3756645 bcsB 7124392 bcsB Escherichia coli IAI1 cellulose synthase regulator protein YP_002388996.1 3754306 R 585034 CDS YP_002388997.1 218556084 7124387 complement(3756656..3759274) 1 NC_011741.1 polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis; cellulose synthase catalytic subunit 3759274 bcsA 7124387 bcsA Escherichia coli IAI1 cellulose synthase catalytic subunit YP_002388997.1 3756656 R 585034 CDS YP_002388998.1 218556085 7124386 complement(3759271..3760023) 1 NC_011741.1 cell division protein 3760023 7124386 ECIAI1_3685 Escherichia coli IAI1 cell division protein YP_002388998.1 3759271 R 585034 CDS YP_002388999.1 218556086 7125627 complement(3760035..3760223) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3760223 yhjR 7125627 yhjR Escherichia coli IAI1 hypothetical protein YP_002388999.1 3760035 R 585034 CDS YP_002389000.1 218556087 7127178 3760496..3762067 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929533, 11260463; Product type pe : putative enzyme; putative cellulose biosynthesis protease 3762067 bcsE 7127178 bcsE Escherichia coli IAI1 putative cellulose biosynthesis protease YP_002389000.1 3760496 D 585034 CDS YP_002389001.1 218556088 7124389 3762064..3762255 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3762255 bcsF 7124389 bcsF Escherichia coli IAI1 hypothetical protein YP_002389001.1 3762064 D 585034 CDS YP_002389002.1 218556089 7124390 3762252..3763931 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929533, 11260463; Product type pe : putative enzyme; putative cellulose biosynthesis endoglucanase 3763931 bcsG 7124390 bcsG Escherichia coli IAI1 putative cellulose biosynthesis endoglucanase YP_002389002.1 3762252 D 585034 CDS YP_002389003.1 218556090 7126605 complement(3764501..3764776) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123448; Product type f : factor; toxic polypeptide, small 3764776 ldrD 7126605 ldrD Escherichia coli IAI1 toxic polypeptide, small YP_002389003.1 3764501 R 585034 CDS YP_002389004.1 218556091 7126402 complement(3764984..3765226) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123448; Product type f : factor; toxic polypeptide, small 3765226 ldrD 7126402 ldrD Escherichia coli IAI1 toxic polypeptide, small YP_002389004.1 3764984 R 585034 CDS YP_002389005.1 218556092 7126606 complement(3765739..3765900) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3765900 7126606 ECIAI1_3696 Escherichia coli IAI1 hypothetical protein YP_002389005.1 3765739 R 585034 CDS YP_002389006.1 218556093 7125628 3766050..3767321 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15901718; Product type t : transporter; transporter 3767321 yhjV 7125628 yhjV Escherichia coli IAI1 transporter YP_002389006.1 3766050 D 585034 CDS YP_002389007.1 218556094 7127179 complement(3767351..3768355) 1 NC_011741.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit 3768355 dppF 7127179 dppF Escherichia coli IAI1 dipeptide transporter ATP-binding subunit YP_002389007.1 3767351 R 585034 CDS YP_002389008.1 218556095 7124620 complement(3768352..3769335) 1 NC_011741.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit 3769335 dppD 7124620 dppD Escherichia coli IAI1 dipeptide transporter ATP-binding subunit YP_002389008.1 3768352 R 585034 CDS YP_002389009.1 218556096 7124619 complement(3769346..3770248) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7536291; Product type t : transporter; dipeptide transporter 3770248 dppC 7124619 dppC Escherichia coli IAI1 dipeptide transporter YP_002389009.1 3769346 R 585034 CDS YP_002389010.1 218556097 7124618 complement(3770258..3771277) 1 NC_011741.1 transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB 3771277 dppB 7124618 dppB Escherichia coli IAI1 dipeptide transporter permease DppB YP_002389010.1 3770258 R 585034 CDS YP_002389011.1 218556098 7124617 3771295..3771438 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3771438 7124617 ECIAI1_3702 Escherichia coli IAI1 hypothetical protein YP_002389011.1 3771295 D 585034 CDS YP_002389012.1 218556099 7125629 complement(3771428..3773035) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100289, 92065799, 1702779, 1956284, 7536291, 8527431, 8563629, 9298646, 9600841, 9740056, 10972807; Product type t : transporter; dipeptide ABC transporter periplasmic-binding protein 3773035 dppA 7125629 dppA Escherichia coli IAI1 dipeptide ABC transporter periplasmic-binding protein YP_002389012.1 3771428 R 585034 CDS YP_002389013.1 218556100 7124616 3773741..3774073 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3774073 7124616 ECIAI1_3704 Escherichia coli IAI1 hypothetical protein YP_002389013.1 3773741 D 585034 CDS YP_002389014.1 218556101 7128033 complement(3774116..3775807) 1 NC_011741.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase 3775807 eptB 7128033 eptB Escherichia coli IAI1 phosphoethanolamine transferase YP_002389014.1 3774116 R 585034 CDS YP_002389015.1 218556102 7125087 complement(3776060..3776584) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type pm : putative membrane component; LpfE protein 3776584 lpfE 7125087 lpfE Escherichia coli IAI1 LpfE protein YP_002389015.1 3776060 R 585034 CDS YP_002389016.1 218556103 7127617 complement(3776590..3777645) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; LpfD protein 3777645 lpfD 7127617 lpfD Escherichia coli IAI1 LpfD protein YP_002389016.1 3776590 R 585034 CDS YP_002389017.1 218556104 7127615 complement(3777656..3780187) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; outer membrane usher protein lpfC 3780187 lpfC 7127615 lpfC Escherichia coli IAI1 outer membrane usher protein lpfC YP_002389017.1 3777656 R 585034 CDS YP_002389018.1 218556105 7126444 complement(3780211..3780897) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; Chaperone protein lpfB 3780897 lpfB 7126444 lpfB Escherichia coli IAI1 Chaperone protein lpfB YP_002389018.1 3780211 R 585034 CDS YP_002389019.1 218556106 7126443 complement(3780981..3781505) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; Long polar fimbria protein A 3781505 lpfA 7126443 lpfA Escherichia coli IAI1 Long polar fimbria protein A YP_002389019.1 3780981 R 585034 CDS YP_002389020.1 218556107 7126441 complement(3781830..3783077) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3783077 yhjX 7126441 yhjX Escherichia coli IAI1 putative transporter YP_002389020.1 3781830 R 585034 CDS YP_002389021.1 218556108 7127180 complement(3783261..3783959) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3783959 yhjY 7127180 yhjY Escherichia coli IAI1 hypothetical protein YP_002389021.1 3783261 R 585034 CDS YP_002389022.1 218556109 7127181 3784117..3784680 1 NC_011741.1 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyl-adenine DNA glycosylase I 3784680 tag 7127181 tag Escherichia coli IAI1 3-methyl-adenine DNA glycosylase I YP_002389022.1 3784117 D 585034 CDS YP_002389023.1 218556110 7126207 3784677..3785117 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11237876; Product type pe : putative enzyme; hypothetical protein 3785117 yiaC 7126207 yiaC Escherichia coli IAI1 hypothetical protein YP_002389023.1 3784677 D 585034 CDS YP_002389024.1 218556111 7127184 complement(3785086..3787365) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82119950, 90202748, 2180922, 374979; Product type e : enzyme; biotin sulfoxide reductase 3787365 bisC 7127184 bisC Escherichia coli IAI1 biotin sulfoxide reductase YP_002389024.1 3785086 R 585034 CDS YP_002389025.1 218556112 7124415 3787572..3788231 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein 3788231 yiaD 7124415 yiaD Escherichia coli IAI1 putative outer membrane lipoprotein YP_002389025.1 3787572 D 585034 CDS YP_002389026.1 218556113 7127185 3788335..3789309 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15801772, 11237876, 99030322, 99357626, 9298646, 9811658; Product type e : enzyme; 2-oxo-carboxylic acid reductase 3789309 tiaE 7127185 tiaE Escherichia coli IAI1 2-oxo-carboxylic acid reductase YP_002389026.1 3788335 D 585034 CDS YP_002389027.1 218556114 7126258 complement(3789359..3790069) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3790069 yiaF 7126258 yiaF Escherichia coli IAI1 hypothetical protein YP_002389027.1 3789359 R 585034 CDS YP_002389028.1 218556115 7127186 3790503..3790793 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3790793 yiaG 7127186 yiaG Escherichia coli IAI1 putative transcriptional regulator YP_002389028.1 3790503 D 585034 CDS YP_002389029.1 218556116 7127187 complement(3791011..3791433) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3791433 7127187 ECIAI1_3721 Escherichia coli IAI1 hypothetical protein YP_002389029.1 3791011 R 585034 CDS YP_002389030.1 218556117 7125631 3791074..3791286 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20345064, 90115858, 94293754, 94293756, 99177178, 10696873, 1597410, 1961761, 2404279, 7515185, 8197194, 9405743, 9439003, 9692981; Product type f : factor; major cold shock protein 3791286 cspA 7125631 cspA Escherichia coli IAI1 major cold shock protein YP_002389030.1 3791074 D 585034 CDS YP_002389031.1 218556118 7125931 complement(3791952..3794021) 1 NC_011741.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 3794021 glyS 7125931 glyS Escherichia coli IAI1 glycyl-tRNA synthetase subunit beta YP_002389031.1 3791952 R 585034 CDS YP_002389032.1 218556119 7128360 complement(3794031..3794942) 1 NC_011741.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 3794942 glyQ 7128360 glyQ Escherichia coli IAI1 glycyl-tRNA synthetase subunit alpha YP_002389032.1 3794031 R 585034 CDS YP_002389033.1 218556120 7128359 complement(3795037..3795336) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3795336 ysaB 7128359 ysaB Escherichia coli IAI1 hypothetical protein YP_002389033.1 3795037 R 585034 CDS YP_002389034.1 218556121 7128104 3795511..3796506 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3796506 yiaH 7128104 yiaH Escherichia coli IAI1 hypothetical protein YP_002389034.1 3795511 D 585034 CDS YP_002389035.1 218556122 7127188 complement(3796548..3796985) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3796985 yiaA 7127188 yiaA Escherichia coli IAI1 hypothetical protein YP_002389035.1 3796548 R 585034 CDS YP_002389036.1 218556123 7127182 complement(3797031..3797372) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6320721; Product type pm : putative membrane component; hypothetical protein 3797372 yiaB 7127182 yiaB Escherichia coli IAI1 hypothetical protein YP_002389036.1 3797031 R 585034 CDS YP_002389037.1 218556124 7127183 complement(3797541..3798995) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6330500, 92366447, 95050816, 6320721; Product type e : enzyme; xylulokinase 3798995 xylB 7127183 xylB Escherichia coli IAI1 xylulokinase YP_002389037.1 3797541 R 585034 CDS YP_002389038.1 218556125 7126478 complement(3799067..3800389) 1 NC_011741.1 catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase 3800389 xylA 7126478 xylA Escherichia coli IAI1 xylose isomerase YP_002389038.1 3799067 R 585034 CDS YP_002389039.1 218556126 7126477 3800755..3801747 1 NC_011741.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 3801747 xylF 7126477 xylF Escherichia coli IAI1 D-xylose transporter subunit XylF YP_002389039.1 3800755 D 585034 CDS YP_002389040.1 218556127 7126480 3801825..3803366 1 NC_011741.1 with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit 3803366 xylG 7126480 xylG Escherichia coli IAI1 xylose transporter ATP-binding subunit YP_002389040.1 3801825 D 585034 CDS YP_002389041.1 218556128 7126481 3803344..3804525 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94316500; Product type t : transporter; D-xylose ABC transporter membrane protein 3804525 xylH 7126481 xylH Escherichia coli IAI1 D-xylose ABC transporter membrane protein YP_002389041.1 3803344 D 585034 CDS YP_002389042.1 218556129 7126482 3804437..3804613 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 3804613 7126482 ECIAI1_3734 Escherichia coli IAI1 hypothetical protein YP_002389042.1 3804437 D 585034 CDS YP_002389043.1 218556130 7125632 3804603..3805781 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6330500, 94316500; Product type r : regulator; DNA-binding transcriptional activator, xylose-binding 3805781 xylR 7125632 xylR Escherichia coli IAI1 DNA-binding transcriptional activator, xylose-binding YP_002389043.1 3804603 D 585034 CDS YP_002389044.1 218556131 7126483 complement(3805889..3806713) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1544897; hypothetical protein 3806713 bax 7126483 bax Escherichia coli IAI1 hypothetical protein YP_002389044.1 3805889 R 585034 CDS YP_002389045.1 218556132 7124383 3807033..3809063 1 NC_011741.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase 3809063 malS 7124383 malS Escherichia coli IAI1 periplasmic alpha-amylase YP_002389045.1 3807033 D 585034 CDS YP_002389046.1 218556133 7127662 3809241..3810494 1 NC_011741.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 3810494 avtA 7127662 avtA Escherichia coli IAI1 valine--pyruvate transaminase YP_002389046.1 3809241 D 585034 CDS YP_002389047.1 218556134 7126283 complement(3810646..3811119) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative hydrogenase, 4Fe-4S ferredoxin-type component 3811119 yiaI 7126283 yiaI Escherichia coli IAI1 putative hydrogenase, 4Fe-4S ferredoxin-type component YP_002389047.1 3810646 R 585034 CDS YP_002389048.1 218556135 7127189 complement(3811221..3812069) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 20372646, 9826648; Product type r : regulator; DNA-binding transcriptional repressor 3812069 yiaJ 7127189 yiaJ Escherichia coli IAI1 DNA-binding transcriptional repressor YP_002389048.1 3811221 R 585034 CDS YP_002389049.1 218556136 7127190 3812270..3813268 1 NC_011741.1 NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; 2,3-diketo-L-gulonate reductase 3813268 yiaK 7127190 yiaK Escherichia coli IAI1 2,3-diketo-L-gulonate reductase YP_002389049.1 3812270 D 585034 CDS YP_002389050.1 218556137 7127191 3813280..3813747 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21617392; hypothetical protein 3813747 yiaL 7127191 yiaL Escherichia coli IAI1 hypothetical protein YP_002389050.1 3813280 D 585034 CDS YP_002389051.1 218556138 7127192 3813865..3814338 1 NC_011741.1 membrane-spanning protein involved in uptake of 2,3-diketo-L-gulonate; part of the tri-partite ATP-independent periplasmic transport system (TRAP) YiaMNO; 2,3-diketo-L-gulonate TRAP transporter small permease YiaM 3814338 yiaM 7127192 yiaM Escherichia coli IAI1 2,3-diketo-L-gulonate TRAP transporter small permease YiaM YP_002389051.1 3813865 D 585034 CDS YP_002389052.1 218556139 7127193 3814341..3815618 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14668138, 21617392; Product type t : transporter; transporter 3815618 yiaN 7127193 yiaN Escherichia coli IAI1 transporter YP_002389052.1 3814341 D 585034 CDS YP_002389053.1 218556140 7127194 3815631..3816617 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14668138, 21617392; Product type t : transporter; transporter 3816617 yiaO 7127194 yiaO Escherichia coli IAI1 transporter YP_002389053.1 3815631 D 585034 CDS YP_002389054.1 218556141 7127195 3816621..3818117 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21617392, 95050816, 7961955; Product type e : enzyme; L-xylulose kinase 3818117 lyxK 7127195 lyxK Escherichia coli IAI1 L-xylulose kinase YP_002389054.1 3816621 D 585034 CDS YP_002389055.1 218556142 7127648 3818114..3818776 1 NC_011741.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate; 3-keto-L-gulonate-6-phosphate decarboxylase 3818776 sgbH 7127648 sgbH Escherichia coli IAI1 3-keto-L-gulonate-6-phosphate decarboxylase YP_002389055.1 3818114 D 585034 CDS YP_002389056.1 218556143 7127924 3818769..3819629 1 NC_011741.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; putative L-xylulose 5-phosphate 3-epimerase 3819629 sgbU 7127924 sgbU Escherichia coli IAI1 putative L-xylulose 5-phosphate 3-epimerase YP_002389056.1 3818769 D 585034 CDS YP_002389057.1 218556144 7127925 3819623..3820318 1 NC_011741.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 3820318 sgbE 7127925 sgbE Escherichia coli IAI1 L-ribulose-5-phosphate 4-epimerase YP_002389057.1 3819623 D 585034 CDS YP_002389058.1 218556145 7127923 complement(3820665..3821405) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3821405 yiaT 7127923 yiaT Escherichia coli IAI1 hypothetical protein YP_002389058.1 3820665 R 585034 CDS YP_002389059.1 218556146 7127196 3821529..3822503 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3822503 yiaU 7127196 yiaU Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002389059.1 3821529 D 585034 CDS YP_002389060.1 218556147 7127197 complement(3822500..3823636) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15668009; Product type t : transporter; membrane fusion protein (MFP) component of efflux pump 3823636 yiaV 7127197 yiaV Escherichia coli IAI1 membrane fusion protein (MFP) component of efflux pump YP_002389060.1 3822500 R 585034 CDS YP_002389061.1 218556148 7127198 complement(3823642..3823965) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3823965 yiaW 7127198 yiaW Escherichia coli IAI1 hypothetical protein YP_002389061.1 3823642 R 585034 CDS YP_002389062.1 218556149 7127199 3824079..3824291 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3824291 7127199 ECIAI1_3755 Escherichia coli IAI1 hypothetical protein YP_002389062.1 3824079 D 585034 CDS YP_002389063.1 218556150 7125633 complement(3824510..3826048) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95286498, 7768815; Product type e : enzyme; aldehyde dehydrogenase B 3826048 aldB 7125633 aldB Escherichia coli IAI1 aldehyde dehydrogenase B YP_002389063.1 3824510 R 585034 CDS YP_002389064.1 218556151 7125742 complement(3826213..3827364) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2935393; Product type e : enzyme; putative alcohol dehydrogenase 3827364 yiaY 7125742 yiaY Escherichia coli IAI1 putative alcohol dehydrogenase YP_002389064.1 3826213 R 585034 CDS YP_002389065.1 218556152 7127200 complement(3827554..3829398) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264431, 91317715, 9315303, 94148228, 2140572, 2531290; Product type f : factor; selenocysteinyl-tRNA-specific translation factor 3829398 selB 7127200 selB Escherichia coli IAI1 selenocysteinyl-tRNA-specific translation factor YP_002389065.1 3827554 R 585034 CDS YP_002389066.1 218556153 7124700 complement(3829395..3830786) 1 NC_011741.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 3830786 selA 7124700 selA Escherichia coli IAI1 selenocysteine synthase YP_002389066.1 3829395 R 585034 CDS YP_002389067.1 218556154 7124699 complement(3830884..3831492) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8387990; Product type pe : putative enzyme; putative glutathione S-transferase 3831492 yibF 7124699 yibF Escherichia coli IAI1 putative glutathione S-transferase YP_002389067.1 3830884 R 585034 CDS YP_002389068.1 218556155 7127202 3831491..3831634 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3831634 7127202 ECIAI1_3761 Escherichia coli IAI1 hypothetical protein YP_002389068.1 3831491 D 585034 CDS YP_002389069.1 218556156 7125635 3835961..3836422 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3836422 yibG 7125635 yibG Escherichia coli IAI1 hypothetical protein YP_002389069.1 3835961 D 585034 CDS YP_002389070.1 218556157 7127203 3836604..3836762 1 NC_011741.1 Ankyrin repeat domain-containing protein 52 (fragment) 3836762 7127203 ECIAI1_3765 Escherichia coli IAI1 Ankyrin repeat domain-containing protein 52 (fragment) YP_002389070.1 3836604 D 585034 CDS YP_002389071.1 218556158 7125636 3837129..3837566 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3837566 7125636 ECIAI1_3766 Escherichia coli IAI1 hypothetical protein YP_002389071.1 3837129 D 585034 CDS YP_002389072.1 218556159 7125637 complement(3838026..3839162) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3839162 yibH 7125637 yibH Escherichia coli IAI1 hypothetical protein YP_002389072.1 3838026 R 585034 CDS YP_002389073.1 218556160 7127204 complement(3839165..3839527) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3839527 yibI 7127204 yibI Escherichia coli IAI1 hypothetical protein YP_002389073.1 3839165 R 585034 CDS YP_002389074.1 218556161 7127205 3840064..3841977 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92052139, 92283796, 94131964, 1946374, 3135464, 3142516, 6309813, 9551558; Product type t : transporter; PTS system mannitol-specific transporter subunit IIABC 3841977 mtlA 7127205 mtlA Escherichia coli IAI1 PTS system mannitol-specific transporter subunit IIABC YP_002389074.1 3840064 D 585034 CDS YP_002389075.1 218556162 7124485 3842207..3843355 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90254197, 1964486, 3135464, 6384188, 8300537, 13295236; Product type e : enzyme; mannitol-1-phosphate 5-dehydrogenase 3843355 mtlD 7124485 mtlD Escherichia coli IAI1 mannitol-1-phosphate 5-dehydrogenase YP_002389075.1 3842207 D 585034 CDS YP_002389076.1 218556163 7124486 3843355..3843942 1 NC_011741.1 Acts as a repressor of the mtlAD operon; mannitol repressor protein 3843942 mtlR 7124486 mtlR Escherichia coli IAI1 mannitol repressor protein YP_002389076.1 3843355 D 585034 CDS YP_002389077.1 218556164 7124487 complement(3843954..3844163) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3844163 yibT 7124487 yibT Escherichia coli IAI1 hypothetical protein YP_002389077.1 3843954 R 585034 CDS YP_002389078.1 218556165 7128141 3844448..3844810 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3844810 yibL 7128141 yibL Escherichia coli IAI1 hypothetical protein YP_002389078.1 3844448 D 585034 CDS YP_002389079.1 218556166 7128138 3845353..3846036 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3846036 7128138 ECIAI1_3774 Escherichia coli IAI1 hypothetical protein YP_002389079.1 3845353 D 585034 CDS YP_002389080.1 218556167 7125638 3846080..3850930 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3850930 7125638 ECIAI1_3775 Escherichia coli IAI1 hypothetical protein YP_002389080.1 3846080 D 585034 CDS YP_002389081.1 218556168 7125639 3851299..3852954 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012541, 11283302, 11785976, 8407843; Product type t : transporter; L-lactate permease 3852954 lldP 7125639 lldP Escherichia coli IAI1 L-lactate permease YP_002389081.1 3851299 D 585034 CDS YP_002389082.1 218556169 7126430 3852954..3853730 1 NC_011741.1 represses the lctPRD operon; DNA-binding transcriptional repressor LldR 3853730 lldR 7126430 lldR Escherichia coli IAI1 DNA-binding transcriptional repressor LldR YP_002389082.1 3852954 D 585034 CDS YP_002389083.1 218556170 7126431 3853727..3854917 1 NC_011741.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 3854917 lldD 7126431 lldD Escherichia coli IAI1 L-lactate dehydrogenase YP_002389083.1 3853727 D 585034 CDS YP_002389084.1 218556171 7126429 3855103..3855576 1 NC_011741.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; putative tRNA/rRNA methyltransferase YibK 3855576 yibK 7126429 yibK Escherichia coli IAI1 putative tRNA/rRNA methyltransferase YibK YP_002389084.1 3855103 D 585034 CDS YP_002389085.1 218556172 7124461 complement(3855629..3856450) 1 NC_011741.1 catalyzes the O-acetylation of serine; serine acetyltransferase 3856450 cysE 7124461 cysE Escherichia coli IAI1 serine acetyltransferase YP_002389085.1 3855629 R 585034 CDS YP_002389086.1 218556173 7126891 complement(3856530..3857549) 1 NC_011741.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 3857549 gpsA 7126891 gpsA Escherichia coli IAI1 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_002389086.1 3856530 R 585034 CDS YP_002389087.1 218556174 7128461 complement(3857549..3858016) 1 NC_011741.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 3858016 secB 7128461 secB Escherichia coli IAI1 preprotein translocase subunit SecB YP_002389087.1 3857549 R 585034 CDS YP_002389088.1 218556175 7124692 complement(3858079..3858330) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94316500, 95024051, 99175138, 11031118, 7937896, 8636094, 9973569; Product type c : carrier; glutaredoxin 3 3858330 grxC 7124692 grxC Escherichia coli IAI1 glutaredoxin 3 YP_002389088.1 3858079 R 585034 CDS YP_002389089.1 218556176 7128470 complement(3858472..3858903) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative rhodanese-related sulfurtransferase 3858903 yibN 7128470 yibN Escherichia coli IAI1 putative rhodanese-related sulfurtransferase YP_002389089.1 3858472 R 585034 CDS YP_002389090.1 218556177 7128139 3859148..3860692 1 NC_011741.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 3860692 gpmI 7128139 gpmI Escherichia coli IAI1 phosphoglyceromutase YP_002389090.1 3859148 D 585034 CDS YP_002389091.1 218556178 7128459 3860726..3861985 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12113939, 21972773; Product type cp : cell process; hypothetical protein 3861985 envC 7128459 envC Escherichia coli IAI1 hypothetical protein YP_002389091.1 3860726 D 585034 CDS YP_002389092.1 218556179 7125074 3861989..3862948 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative polysaccharide deacetylase 3862948 yibQ 7125074 yibQ Escherichia coli IAI1 putative polysaccharide deacetylase YP_002389092.1 3861989 D 585034 CDS YP_002389093.1 218556180 7128140 complement(3862935..3863969) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15659689, 2647748; Product type pe : putative enzyme; putative glycosyl transferase 3863969 yibD 7128140 yibD Escherichia coli IAI1 putative glycosyl transferase YP_002389093.1 3862935 R 585034 CDS YP_002389094.1 218556181 7127201 complement(3864208..3865233) 1 NC_011741.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 3865233 tdh 7127201 tdh Escherichia coli IAI1 L-threonine 3-dehydrogenase YP_002389094.1 3864208 R 585034 CDS YP_002389095.1 218556182 7126232 complement(3865243..3866439) 1 NC_011741.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase 3866439 kbl 7126232 kbl Escherichia coli IAI1 2-amino-3-ketobutyrate coenzyme A ligase YP_002389095.1 3865243 R 585034 CDS YP_002389096.1 218556183 7126096 3866653..3867585 1 NC_011741.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-mannoheptose-6-epimerase 3867585 rfaD 7126096 rfaD Escherichia coli IAI1 ADP-L-glycero-D-mannoheptose-6-epimerase YP_002389096.1 3866653 D 585034 CDS YP_002389097.1 218556184 7125575 3867595..3868641 1 NC_011741.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose:LPS heptosyltransferase II 3868641 waaF 7125575 waaF Escherichia coli IAI1 ADP-heptose:LPS heptosyltransferase II YP_002389097.1 3867595 D 585034 CDS YP_002389098.1 218556185 7125576 3868645..3869616 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20507564, 92250420, 93239678, 9446588, 1624462, 8478319; Product type e : enzyme; ADP-heptose:LPS heptosyl transferase I 3869616 waaC 7125576 waaC Escherichia coli IAI1 ADP-heptose:LPS heptosyl transferase I YP_002389098.1 3868645 D 585034 CDS YP_002389099.1 218556186 7125574 complement(3869686..3870939) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92250420, 92325067, 93054344, 1624462; Product type e : enzyme; lipid A-core surface O-antigen ligase 3870939 waaL 7125574 waaL Escherichia coli IAI1 lipid A-core surface O-antigen ligase YP_002389099.1 3869686 R 585034 CDS YP_002389100.1 218556187 7125578 complement(3870985..3871968) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative beta1,3-glucosyltransferase 3871968 waaV 7125578 waaV Escherichia coli IAI1 putative beta1,3-glucosyltransferase YP_002389100.1 3870985 R 585034 CDS YP_002389101.1 218556188 7125583 complement(3872053..3873078) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9791168, 9756860, 9792656; Product type e : enzyme; UDP-galactose:(Galactosyl) LPS alpha1, 2-galactosyltransferase 3873078 waaW 7125583 waaW Escherichia coli IAI1 UDP-galactose:(Galactosyl) LPS alpha1, 2-galactosyltransferase YP_002389101.1 3872053 R 585034 CDS YP_002389102.1 218556189 7125584 complement(3873104..3873796) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92250420, 92325067, 9756860; Product type e : enzyme; lipopolysaccharide core biosynthesis protein 3873796 waaY 7125584 waaY Escherichia coli IAI1 lipopolysaccharide core biosynthesis protein YP_002389102.1 3873104 R 585034 CDS YP_002389103.1 218556190 7125585 complement(3873806..3874801) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9791168, 9756860, 9792656; Product type e : enzyme; UDP-galactose:(glucosyl) LPS alpha1, 2-galactosyltransferase 3874801 waaT 7125585 waaT Escherichia coli IAI1 UDP-galactose:(glucosyl) LPS alpha1, 2-galactosyltransferase YP_002389103.1 3873806 R 585034 CDS YP_002389104.1 218556191 7125582 complement(3874818..3875834) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme; UDP-glucose:(glucosyl) LPS alpha1, 3-glucosyltransferase 3875834 waaO 7125582 waaO Escherichia coli IAI1 UDP-glucose:(glucosyl) LPS alpha1, 3-glucosyltransferase YP_002389104.1 3874818 R 585034 CDS YP_002389105.1 218556192 7125579 complement(3875850..3876656) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101922, 92121133, 92210496, 9756860, 1732225; Product type e : enzyme; kinase that phosphorylates core heptose of lipopolysaccharide 3876656 waaP 7125579 waaP Escherichia coli IAI1 kinase that phosphorylates core heptose of lipopolysaccharide YP_002389105.1 3875850 R 585034 CDS YP_002389106.1 218556193 7125580 complement(3876640..3877764) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92121133, 92210496, 92250420, 1447141, 1732225, 7988890; Product type e : enzyme; glucosyltransferase I 3877764 waaG 7125580 waaG Escherichia coli IAI1 glucosyltransferase I YP_002389106.1 3876640 R 585034 CDS YP_002389107.1 218556194 7125577 complement(3877761..3878819) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9756860, 1447141, 1732225; Product type e : enzyme; lipopolysaccharide core biosynthesis protein 3878819 waaQ 7125577 waaQ Escherichia coli IAI1 lipopolysaccharide core biosynthesis protein YP_002389107.1 3877761 R 585034 CDS YP_002389108.1 218556195 7125581 3879223..3880500 1 NC_011741.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 3880500 kdtA 7125581 kdtA Escherichia coli IAI1 3-deoxy-D-manno-octulosonic-acid transferase YP_002389108.1 3879223 D 585034 CDS YP_002389109.1 218556196 7126382 3880508..3880987 1 NC_011741.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 3880987 coaD 7126382 coaD Escherichia coli IAI1 phosphopantetheine adenylyltransferase YP_002389109.1 3880508 D 585034 CDS YP_002389110.1 218556197 7126343 complement(3881026..3881835) 1 NC_011741.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 3881835 mutM 7126343 mutM Escherichia coli IAI1 formamidopyrimidine-DNA glycosylase YP_002389110.1 3881026 R 585034 CDS YP_002389111.1 218556198 7124504 complement(3881933..3882100) 1 NC_011741.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 3882100 rpmG 7124504 rpmG Escherichia coli IAI1 50S ribosomal protein L33 YP_002389111.1 3881933 R 585034 CDS YP_002389112.1 218556199 7128393 complement(3882121..3882357) 1 NC_011741.1 required for 70S ribosome assembly; 50S ribosomal protein L28 3882357 rpmB 7128393 rpmB Escherichia coli IAI1 50S ribosomal protein L28 YP_002389112.1 3882121 R 585034 CDS YP_002389113.1 218556200 7128388 3882447..3882569 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3882569 7128388 ECIAI1_3808 Escherichia coli IAI1 hypothetical protein YP_002389113.1 3882447 D 585034 CDS YP_002389114.1 218556201 7125640 complement(3882574..3883242) 1 NC_011741.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 3883242 radC 7125640 radC Escherichia coli IAI1 DNA repair protein RadC YP_002389114.1 3882574 R 585034 CDS YP_002389115.1 218556202 7128152 3883414..3884634 1 NC_011741.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 3884634 dfp 7128152 dfp Escherichia coli IAI1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_002389115.1 3883414 D 585034 CDS YP_002389116.1 218556203 7124570 3884615..3885070 1 NC_011741.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 3885070 dut 7124570 dut Escherichia coli IAI1 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_002389116.1 3884615 D 585034 CDS YP_002389117.1 218556204 7125034 3885177..3885773 1 NC_011741.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 3885773 slmA 7125034 slmA Escherichia coli IAI1 nucleoid occlusion protein YP_002389117.1 3885177 D 585034 CDS YP_002389118.1 218556205 7127515 complement(3885810..3886451) 1 NC_011741.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 3886451 pyrE 7127515 pyrE Escherichia coli IAI1 orotate phosphoribosyltransferase YP_002389118.1 3885810 R 585034 CDS YP_002389119.1 218556206 7126572 complement(3886516..3887256) 1 NC_011741.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 3887256 rph 7126572 rph Escherichia coli IAI1 ribonuclease PH YP_002389119.1 3886516 R 585034 CDS YP_002389120.1 218556207 7128616 3887359..3888222 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3888222 yicC 7128616 yicC Escherichia coli IAI1 hypothetical protein YP_002389120.1 3887359 D 585034 CDS YP_002389121.1 218556208 7128142 3888431..3889045 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type cp : cell process; DNA-damage-inducible protein D 3889045 dinD 7128142 dinD Escherichia coli IAI1 DNA-damage-inducible protein D YP_002389121.1 3888431 D 585034 CDS YP_002389122.1 218556209 7124587 3889336..3889953 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3889953 yicG 7124587 yicG Escherichia coli IAI1 hypothetical protein YP_002389122.1 3889336 D 585034 CDS YP_002389123.1 218556210 7128144 complement(3889950..3891632) 1 NC_011741.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB 3891632 ligB 7128144 ligB Escherichia coli IAI1 NAD-dependent DNA ligase LigB YP_002389123.1 3889950 R 585034 CDS YP_002389124.1 218556211 7126419 3891890..3892513 1 NC_011741.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 3892513 gmk 7126419 gmk Escherichia coli IAI1 guanylate kinase YP_002389124.1 3891890 D 585034 CDS YP_002389125.1 218556212 7128363 3892568..3892843 1 NC_011741.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 3892843 rpoZ 7128363 rpoZ Escherichia coli IAI1 DNA-directed RNA polymerase subunit omega YP_002389125.1 3892568 D 585034 CDS YP_002389126.1 218556213 7128405 3892862..3894970 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12224635, 89255395, 93266525, 94068533, 2005134, 2549050; Product type e : enzyme; bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 3894970 spoT 7128405 spoT Escherichia coli IAI1 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase YP_002389126.1 3892862 D 585034 CDS YP_002389127.1 218556214 7127962 3894977..3895666 1 NC_011741.1 specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 3895666 trmH 7127962 trmH Escherichia coli IAI1 tRNA guanosine-2'-O-methyltransferase YP_002389127.1 3894977 D 585034 CDS YP_002389128.1 218556215 7127492 3895672..3897753 1 NC_011741.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 3897753 recG 7127492 recG Escherichia coli IAI1 ATP-dependent DNA helicase RecG YP_002389128.1 3895672 D 585034 CDS YP_002389129.1 218556216 7124950 complement(3897738..3898604) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3898604 7124950 ECIAI1_3825 Escherichia coli IAI1 hypothetical protein YP_002389129.1 3897738 R 585034 CDS YP_002389130.1 218556217 7125641 complement(3898607..3899812) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91203811, 93106943, 1544582, 2017136, 2254324; Product type t : transporter; glutamate transporter 3899812 gltS 7125641 gltS Escherichia coli IAI1 glutamate transporter YP_002389130.1 3898607 R 585034 CDS YP_002389131.1 218556218 7128354 3900092..3901483 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3901483 yicE 7128354 yicE Escherichia coli IAI1 putative transporter YP_002389131.1 3900092 D 585034 CDS YP_002389132.1 218556219 7128143 3901604..3903313 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3903313 yicH 7128143 yicH Escherichia coli IAI1 hypothetical protein YP_002389132.1 3901604 D 585034 CDS YP_002389133.1 218556220 7128145 complement(3903366..3905684) 1 NC_011741.1 catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase YicI 3905684 yicI 7128145 yicI Escherichia coli IAI1 alpha-xylosidase YicI YP_002389133.1 3903366 R 585034 CDS YP_002389134.1 218556221 7128146 complement(3905694..3907076) 1 NC_011741.1 may be involved in the transport of galactosides-pentoses-hexuronides; putative transporter 3907076 yicJ 7128146 yicJ Escherichia coli IAI1 putative transporter YP_002389134.1 3905694 R 585034 CDS YP_002389135.1 218556222 7128007 3907569..3907712 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 3907712 7128007 ECIAI1_3832 Escherichia coli IAI1 hypothetical protein YP_002389135.1 3907569 D 585034 CDS YP_002389136.1 218556223 7125642 3908100..3909284 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10438463, 10209755; Product type pt : putative transporter; putative sugar efflux system 3909284 setC 7125642 setC Escherichia coli IAI1 putative sugar efflux system YP_002389136.1 3908100 D 585034 CDS YP_002389137.1 218556224 7127914 3909395..3910318 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3910318 yicL 7127914 yicL Escherichia coli IAI1 hypothetical protein YP_002389137.1 3909395 D 585034 CDS YP_002389138.1 218556225 7128148 complement(3910322..3911140) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88298691, 89359178, 9914480, 3003106; Product type lp : lipoprotein; cytoplasmic membrane lipoprotein-28 3911140 nlpA 7128148 nlpA Escherichia coli IAI1 cytoplasmic membrane lipoprotein-28 YP_002389138.1 3910322 R 585034 CDS YP_002389139.1 218556226 7127887 3911362..3911655 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3911655 yicS 7127887 yicS Escherichia coli IAI1 hypothetical protein YP_002389139.1 3911362 D 585034 CDS YP_002389140.1 218556227 7128153 complement(3911696..3913051) 1 NC_011741.1 experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter 3913051 nepI 7128153 nepI Escherichia coli IAI1 ribonucleoside transporter YP_002389140.1 3911696 R 585034 CDS YP_002389141.1 218556228 7128149 complement(3913097..3913549) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3913549 yicN 7128149 yicN Escherichia coli IAI1 hypothetical protein YP_002389141.1 3913097 R 585034 CDS YP_002389142.1 218556229 7128150 complement(3913602..3914936) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative xanthine/uracil permease 3914936 yicO 7128150 yicO Escherichia coli IAI1 putative xanthine/uracil permease YP_002389142.1 3913602 R 585034 CDS YP_002389143.1 218556230 7128151 3915111..3916877 1 NC_011741.1 catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 3916877 ade 7128151 ade Escherichia coli IAI1 cryptic adenine deaminase YP_002389143.1 3915111 D 585034 CDS YP_002389144.1 218556231 7125716 complement(3916922..3918313) 1 NC_011741.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter 3918313 uhpT 7125716 uhpT Escherichia coli IAI1 sugar phosphate antiporter YP_002389144.1 3916922 R 585034 CDS YP_002389145.1 218556232 7125530 complement(3918451..3919770) 1 NC_011741.1 membrane protein regulates uhpT expression; regulatory protein UhpC 3919770 uhpC 7125530 uhpC Escherichia coli IAI1 regulatory protein UhpC YP_002389145.1 3918451 R 585034 CDS YP_002389146.1 218556233 7125529 complement(3919780..3921282) 1 NC_011741.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB 3921282 uhpB 7125529 uhpB Escherichia coli IAI1 sensory histidine kinase UhpB YP_002389146.1 3919780 R 585034 CDS YP_002389147.1 218556234 7125528 complement(3921282..3921872) 1 NC_011741.1 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; DNA-binding transcriptional activator UhpA 3921872 uhpA 7125528 uhpA Escherichia coli IAI1 DNA-binding transcriptional activator UhpA YP_002389147.1 3921282 R 585034 CDS YP_002389148.1 218556235 7125527 complement(3921947..3922237) 1 NC_011741.1 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit 3922237 ilvN 7125527 ilvN Escherichia coli IAI1 acetolactate synthase 1 regulatory subunit YP_002389148.1 3921947 R 585034 CDS YP_002389149.1 218556236 7126060 complement(3922241..3923929) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2989782, 85242083, 92380929, 2989781; Product type e : enzyme; acetolactate synthase catalytic subunit 3923929 ilvB 7126060 ilvB Escherichia coli IAI1 acetolactate synthase catalytic subunit YP_002389149.1 3922241 R 585034 CDS YP_002389151.1 218556237 7126051 complement(3924035..3924133) 1 NC_011741.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; ilvB operon leader peptide 3924133 ivbL 7126051 ivbL Escherichia coli IAI1 ilvB operon leader peptide YP_002389151.1 3924035 R 585034 CDS YP_002389152.1 218556238 7126089 3924407..3924565 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3924565 7126089 ECIAI1_3849 Escherichia coli IAI1 hypothetical protein YP_002389152.1 3924407 D 585034 CDS YP_002389153.1 218556239 7125643 complement(3924662..3924913) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 3924913 7125643 ECIAI1_3850 Escherichia coli IAI1 hypothetical protein YP_002389153.1 3924662 R 585034 CDS YP_002389154.1 218556240 7125644 3925206..3926390 1 NC_011741.1 multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 3926390 emrD 7125644 emrD Escherichia coli IAI1 multidrug resistance protein D YP_002389154.1 3925206 D 585034 CDS YP_002389155.1 218556241 7125062 complement(3926398..3926895) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3926895 yidF 7125062 yidF Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002389155.1 3926398 R 585034 CDS YP_002389156.1 218556242 7128159 complement(3926892..3927254) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3927254 yidG 7128159 yidG Escherichia coli IAI1 hypothetical protein YP_002389156.1 3926892 R 585034 CDS YP_002389157.1 218556243 7128160 complement(3927244..3927591) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3927591 yidH 7128160 yidH Escherichia coli IAI1 hypothetical protein YP_002389157.1 3927244 R 585034 CDS YP_002389158.1 218556244 7128161 3927701..3928150 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3928150 yidI 7128161 yidI Escherichia coli IAI1 hypothetical protein YP_002389158.1 3927701 D 585034 CDS YP_002389159.1 218556245 7128162 complement(3928197..3929690) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sulfatase/phosphatase 3929690 yidJ 7128162 yidJ Escherichia coli IAI1 putative sulfatase/phosphatase YP_002389159.1 3928197 R 585034 CDS YP_002389160.1 218556246 7128163 complement(3929687..3931402) 1 NC_011741.1 uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function; putative symporter YidK 3931402 yidK 7128163 yidK Escherichia coli IAI1 putative symporter YidK YP_002389160.1 3929687 R 585034 CDS YP_002389161.1 218556247 7128164 3931539..3932462 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3932462 yidL 7128164 yidL Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002389161.1 3931539 D 585034 CDS YP_002389162.1 218556248 7125646 complement(3933273..3935150) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative PTS system alpha-glucoside-specific EIICB component 3935150 7125646 ECIAI1_3861 Escherichia coli IAI1 putative PTS system alpha-glucoside-specific EIICB component YP_002389162.1 3933273 R 585034 CDS YP_002389163.1 218556249 7125647 3935185..3935901 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3935901 yidP 7125647 yidP Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002389163.1 3935185 D 585034 CDS YP_002389164.1 218556250 7128166 complement(3935898..3937559) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1356969; Product type pt : putative transporter; hypothetical protein 3937559 yidE 7128166 yidE Escherichia coli IAI1 hypothetical protein YP_002389164.1 3935898 R 585034 CDS YP_002389165.1 218556251 7128158 complement(3937756..3938184) 1 NC_011741.1 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB 3938184 ibpB 7128158 ibpB Escherichia coli IAI1 heat shock chaperone IbpB YP_002389165.1 3937756 R 585034 CDS YP_002389166.1 218556252 7126040 complement(3938296..3938709) 1 NC_011741.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA 3938709 ibpA 7126040 ibpA Escherichia coli IAI1 heat shock protein IbpA YP_002389166.1 3938296 R 585034 CDS YP_002389167.1 218556253 7126039 3939015..3939347 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3939347 yidQ 7126039 yidQ Escherichia coli IAI1 hypothetical protein YP_002389167.1 3939015 D 585034 CDS YP_002389168.1 218556254 7128167 complement(3939349..3940563) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3940563 yidR 7128167 yidR Escherichia coli IAI1 hypothetical protein YP_002389168.1 3939349 R 585034 CDS YP_002389169.1 218556255 7128168 3940664..3941728 1 NC_011741.1 FAD/NAD(P)-binding domain; putative oxidoreductase 3941728 cbrA 7128168 cbrA Escherichia coli IAI1 putative oxidoreductase YP_002389169.1 3940664 D 585034 CDS YP_002389170.1 218556256 7124453 complement(3941725..3943017) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type t : transporter; D-galactonate transporter 3943017 dgoT 7124453 dgoT Escherichia coli IAI1 D-galactonate transporter YP_002389170.1 3941725 R 585034 CDS YP_002389171.1 218556257 7124576 complement(3943137..3944285) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type e : enzyme; galactonate dehydratase 3944285 dgoD 7124576 dgoD Escherichia coli IAI1 galactonate dehydratase YP_002389171.1 3943137 R 585034 CDS YP_002389172.1 218556258 7124573 complement(3944282..3944899) 1 NC_011741.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase 3944899 dgoA 7124573 dgoA Escherichia coli IAI1 2-dehydro-3-deoxy-6-phosphogalactonate aldolase YP_002389172.1 3944282 R 585034 CDS YP_002389173.1 218556259 7124572 complement(3944883..3945761) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type e : enzyme; 2-oxo-3-deoxygalactonate kinase 3945761 dgoK 7124572 dgoK Escherichia coli IAI1 2-oxo-3-deoxygalactonate kinase YP_002389173.1 3944883 R 585034 CDS YP_002389174.1 218556260 7124574 complement(3945758..3946447) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 79020349; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3946447 dgoR 7124574 dgoR Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002389174.1 3945758 R 585034 CDS YP_002389175.1 218556261 7124575 3946725..3947381 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 3947381 yidX 7124575 yidX Escherichia coli IAI1 hypothetical protein YP_002389175.1 3946725 D 585034 CDS YP_002389176.1 218556262 7128169 complement(3947427..3948239) 1 NC_011741.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase 3948239 yidA 7128169 yidA Escherichia coli IAI1 sugar phosphatase YP_002389176.1 3947427 R 585034 CDS YP_002389177.1 218556263 7128154 complement(3948354..3948752) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3948752 yidB 7128154 yidB Escherichia coli IAI1 hypothetical protein YP_002389177.1 3948354 R 585034 CDS YP_002389178.1 218556264 7128155 complement(3948992..3951406) 1 NC_011741.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 3951406 gyrB 7128155 gyrB Escherichia coli IAI1 DNA gyrase subunit B YP_002389178.1 3948992 R 585034 CDS YP_002389179.1 218556265 7128486 complement(3951435..3952508) 1 NC_011741.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 3952508 recF 7128486 recF Escherichia coli IAI1 recombination protein F YP_002389179.1 3951435 R 585034 CDS YP_002389180.1 218556266 7124949 complement(3952508..3953608) 1 NC_011741.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 3953608 dnaN 7124949 dnaN Escherichia coli IAI1 DNA polymerase III subunit beta YP_002389180.1 3952508 R 585034 CDS YP_002389181.1 218556267 7124611 complement(3953613..3955016) 1 NC_011741.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 3955016 dnaA 7124611 dnaA Escherichia coli IAI1 chromosomal replication initiation protein YP_002389181.1 3953613 R 585034 CDS YP_002389182.1 218556268 7124604 complement(3955530..3955670) 1 NC_011741.1 hypothetical protein 3955670 7124604 ECIAI1_3881 Escherichia coli IAI1 hypothetical protein YP_002389182.1 3955530 R 585034 CDS YP_002389183.1 218556269 7125648 3955623..3955763 1 NC_011741.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 3955763 rpmH 7125648 rpmH Escherichia coli IAI1 50S ribosomal protein L34 YP_002389183.1 3955623 D 585034 CDS YP_002389184.1 218556270 7128394 3955780..3956139 1 NC_011741.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 3956139 rnpA 7128394 rnpA Escherichia coli IAI1 ribonuclease P YP_002389184.1 3955780 D 585034 CDS YP_002389185.1 218556271 7125025 3956103..3956360 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3956360 yidD 7125025 yidD Escherichia coli IAI1 hypothetical protein YP_002389185.1 3956103 D 585034 CDS YP_002389186.1 218556272 7128157 3956363..3958009 1 NC_011741.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; putative inner membrane protein translocase component YidC 3958009 yidC 7128157 yidC Escherichia coli IAI1 putative inner membrane protein translocase component YidC YP_002389186.1 3956363 D 585034 CDS YP_002389187.1 218556273 7128156 3958115..3959479 1 NC_011741.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 3959479 trmE 7128156 trmE Escherichia coli IAI1 tRNA modification GTPase TrmE YP_002389187.1 3958115 D 585034 CDS YP_002389188.1 218556274 7127491 3959722..3959796 1 NC_011741.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; tryptophanase leader peptide 3959796 tnaC 7127491 tnaC Escherichia coli IAI1 tryptophanase leader peptide YP_002389188.1 3959722 D 585034 CDS YP_002389189.1 218556275 7127457 3960017..3961432 1 NC_011741.1 tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 3961432 tnaA 7127457 tnaA Escherichia coli IAI1 tryptophanase YP_002389189.1 3960017 D 585034 CDS YP_002389190.1 218556276 7127455 3961523..3962770 1 NC_011741.1 tryptophan transporter of low affinity; tryptophan permease TnaB 3962770 tnaB 7127455 tnaB Escherichia coli IAI1 tryptophan permease TnaB YP_002389190.1 3961523 D 585034 CDS YP_002389191.1 218556277 7127456 3962902..3964077 1 NC_011741.1 Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 3964077 mdtL 7127456 mdtL Escherichia coli IAI1 multidrug efflux system protein MdtL YP_002389191.1 3962902 D 585034 CDS YP_002389192.1 218556278 7124231 3964052..3965011 1 NC_011741.1 Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ 3965011 yidZ 7124231 yidZ Escherichia coli IAI1 DNA-binding transcriptional regulator YidZ YP_002389192.1 3964052 D 585034 CDS YP_002389193.1 218556279 7128170 3965156..3965917 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphopantetheinyl transferase 3965917 yieE 7128170 yieE Escherichia coli IAI1 putative phosphopantetheinyl transferase YP_002389193.1 3965156 D 585034 CDS YP_002389194.1 218556280 7128171 3965939..3966505 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14766567; Product type e : enzyme; chromate reductase, Class I, flavoprotein 3966505 yieF 7128171 yieF Escherichia coli IAI1 chromate reductase, Class I, flavoprotein YP_002389194.1 3965939 D 585034 CDS YP_002389195.1 218556281 7128172 complement(3966559..3967896) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3967896 yieG 7128172 yieG Escherichia coli IAI1 hypothetical protein YP_002389195.1 3966559 R 585034 CDS YP_002389196.1 218556282 7128173 3968063..3968728 1 NC_011741.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 3968728 yieH 7128173 yieH Escherichia coli IAI1 6-phosphogluconate phosphatase YP_002389196.1 3968063 D 585034 CDS YP_002389197.1 218556283 7128174 3968795..3969268 1 NC_011741.1 might be involved in hypersensitivity to nitrofurzone; hypothetical protein 3969268 yieI 7128174 yieI Escherichia coli IAI1 hypothetical protein YP_002389197.1 3968795 D 585034 CDS YP_002389198.1 218556284 7128175 3969317..3969904 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3969904 cbrC 7128175 cbrC Escherichia coli IAI1 hypothetical protein YP_002389198.1 3969317 D 585034 CDS YP_002389199.1 218556285 7124454 complement(3969966..3970688) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 6-phosphogluconolactonase 3970688 yieK 7124454 yieK Escherichia coli IAI1 putative 6-phosphogluconolactonase YP_002389199.1 3969966 R 585034 CDS YP_002389200.1 218556286 7128176 complement(3970703..3971899) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative xylanase 3971899 yieL 7128176 yieL Escherichia coli IAI1 putative xylanase YP_002389200.1 3970703 R 585034 CDS YP_002389201.1 218556287 7128177 complement(3971899..3973515) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10027967; Product type t : transporter; carbohydrate-specific outer membrane porin, cryptic 3973515 bglH 7128177 bglH Escherichia coli IAI1 carbohydrate-specific outer membrane porin, cryptic YP_002389201.1 3971899 R 585034 CDS YP_002389202.1 218556288 7124404 complement(3973601..3974995) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 88297127, 92334140, 3034860, 3309161; Product type e : enzyme; cryptic phospho-beta-glucosidase B 3974995 bglB 7124404 bglB Escherichia coli IAI1 cryptic phospho-beta-glucosidase B YP_002389202.1 3973601 R 585034 CDS YP_002389203.1 218556289 7124401 complement(3975014..3976891) 1 NC_011741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system beta-glucoside-specific transporter subunits IIABC 3976891 bglF 7124401 bglF Escherichia coli IAI1 PTS system beta-glucoside-specific transporter subunits IIABC YP_002389203.1 3975014 R 585034 CDS YP_002389204.1 218556290 7124402 complement(3977025..3977861) 1 NC_011741.1 positive regulator of the beta-glucoside operon; transcriptional antiterminator; transcriptional antiterminator BglG 3977861 bglG 7124402 bglG Escherichia coli IAI1 transcriptional antiterminator BglG YP_002389204.1 3977025 R 585034 CDS YP_002389205.1 218556291 7124403 complement(3978147..3978872) 1 NC_011741.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU 3978872 phoU 7124403 phoU Escherichia coli IAI1 transcriptional regulator PhoU YP_002389205.1 3978147 R 585034 CDS YP_002389206.1 218556292 7124221 complement(3978887..3979660) 1 NC_011741.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 3979660 pstB 7124221 pstB Escherichia coli IAI1 phosphate transporter ATP-binding protein YP_002389206.1 3978887 R 585034 CDS YP_002389207.1 218556293 7126531 complement(3979751..3980641) 1 NC_011741.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PtsA 3980641 pstA 7126531 pstA Escherichia coli IAI1 phosphate transporter permease subunit PtsA YP_002389207.1 3979751 R 585034 CDS YP_002389208.1 218556294 7126530 complement(3980641..3981600) 1 NC_011741.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PstC 3981600 pstC 7126530 pstC Escherichia coli IAI1 phosphate transporter permease subunit PstC YP_002389208.1 3980641 R 585034 CDS YP_002389209.1 218556295 7126532 complement(3981687..3982727) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90133909, 2215649, 6321434, 6365894, 9228942, 9298646, 9671506; Product type t : transporter; phosphate ABC transporter periplasmic substrate-binding protein PstS 3982727 pstS 7126532 pstS Escherichia coli IAI1 phosphate ABC transporter periplasmic substrate-binding protein PstS YP_002389209.1 3981687 R 585034 CDS YP_002389210.1 218556296 7126533 complement(3982975..3984048) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12438351, 7721701, 16128397; Product type ps : putative structure; putative fimbrial protein LpfD; putative adhesin 3984048 lpfD 7126533 lpfD Escherichia coli IAI1 putative fimbrial protein LpfD; putative adhesin YP_002389210.1 3982975 R 585034 CDS YP_002389211.1 218556297 7127616 complement(3984059..3986581) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7721701, 16128397; Product type pt : putative transporter; putative fimbrial usher 3986581 lpfC 7127616 lpfC Escherichia coli IAI1 putative fimbrial usher YP_002389211.1 3984059 R 585034 CDS YP_002389212.1 218556298 7127614 complement(3986606..3987337) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16128397, 12438351; Product type pc : putative carrier; putative fimbrial chaperone protein 3987337 lfpB 7127614 lfpB Escherichia coli IAI1 putative fimbrial chaperone protein YP_002389212.1 3986606 R 585034 CDS YP_002389213.1 218556299 7126415 complement(3987385..3987957) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16125910, 12438351; Product type ps : putative structure; putative major fimbrial subunit 3987957 lpfA 7126415 lpfA Escherichia coli IAI1 putative major fimbrial subunit YP_002389213.1 3987385 R 585034 CDS YP_002389214.1 218556300 7126442 complement(3988259..3990088) 1 NC_011741.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 3990088 glmS 7126442 glmS Escherichia coli IAI1 glucosamine--fructose-6-phosphate aminotransferase YP_002389214.1 3988259 R 585034 CDS YP_002389215.1 218556301 7128319 complement(3990250..3991620) 1 NC_011741.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 3991620 glmU 7128319 glmU Escherichia coli IAI1 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_002389215.1 3990250 R 585034 CDS YP_002389216.1 218556302 7128320 complement(3991971..3992390) 1 NC_011741.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 3992390 atpC 7128320 atpC Escherichia coli IAI1 F0F1 ATP synthase subunit epsilon YP_002389216.1 3991971 R 585034 CDS YP_002389217.1 218556303 7126276 complement(3992411..3993793) 1 NC_011741.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 3993793 atpD 7126276 atpD Escherichia coli IAI1 F0F1 ATP synthase subunit beta YP_002389217.1 3992411 R 585034 CDS YP_002389218.1 218556304 7126277 complement(3993820..3994683) 1 NC_011741.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 3994683 atpG 7126277 atpG Escherichia coli IAI1 F0F1 ATP synthase subunit gamma YP_002389218.1 3993820 R 585034 CDS YP_002389219.1 218556305 7126280 complement(3994734..3996275) 1 NC_011741.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 3996275 atpA 7126280 atpA Escherichia coli IAI1 F0F1 ATP synthase subunit alpha YP_002389219.1 3994734 R 585034 CDS YP_002389220.1 218556306 7126274 complement(3996288..3996821) 1 NC_011741.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 3996821 atpH 7126274 atpH Escherichia coli IAI1 F0F1 ATP synthase subunit delta YP_002389220.1 3996288 R 585034 CDS YP_002389221.1 218556307 7126281 complement(3996836..3997306) 1 NC_011741.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 3997306 atpF 7126281 atpF Escherichia coli IAI1 F0F1 ATP synthase subunit B YP_002389221.1 3996836 R 585034 CDS YP_002389222.1 218556308 7126279 complement(3997368..3997607) 1 NC_011741.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 3997607 atpE 7126279 atpE Escherichia coli IAI1 F0F1 ATP synthase subunit C YP_002389222.1 3997368 R 585034 CDS YP_002389223.1 218556309 7126278 complement(3997654..3998469) 1 NC_011741.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 3998469 atpB 7126278 atpB Escherichia coli IAI1 F0F1 ATP synthase subunit A YP_002389223.1 3997654 R 585034 CDS YP_002389224.1 218556310 7126275 complement(3998478..3998858) 1 NC_011741.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I 3998858 atpI 7126275 atpI Escherichia coli IAI1 F0F1 ATP synthase subunit I YP_002389224.1 3998478 R 585034 CDS YP_002389225.1 218556311 7126282 complement(3999475..4000098) 1 NC_011741.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 4000098 gidB 7126282 gidB Escherichia coli IAI1 16S rRNA methyltransferase GidB YP_002389225.1 3999475 R 585034 CDS YP_002389226.1 218556312 7128303 complement(4000162..4002051) 1 NC_011741.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 4002051 gidA 7128303 gidA Escherichia coli IAI1 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA YP_002389226.1 4000162 R 585034 CDS YP_002389227.1 218556313 7128302 complement(4002430..4002873) 1 NC_011741.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 4002873 mioC 7128302 mioC Escherichia coli IAI1 flavodoxin YP_002389227.1 4002430 R 585034 CDS YP_002389228.1 218556314 7124278 complement(4002963..4003421) 1 NC_011741.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 4003421 asnC 7124278 asnC Escherichia coli IAI1 DNA-binding transcriptional regulator AsnC YP_002389228.1 4002963 R 585034 CDS YP_002389229.1 218556315 7126263 4003573..4004565 1 NC_011741.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 4004565 asnA 7126263 asnA Escherichia coli IAI1 asparagine synthetase AsnA YP_002389229.1 4003573 D 585034 CDS YP_002389230.1 218556316 7126261 complement(4004570..4006021) 1 NC_011741.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein 4006021 yieM 7126261 yieM Escherichia coli IAI1 hypothetical protein YP_002389230.1 4004570 R 585034 CDS YP_002389231.1 218556317 7128178 complement(4006015..4007511) 1 NC_011741.1 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA 4007511 ravA 7128178 ravA Escherichia coli IAI1 regulatory ATPase RavA YP_002389231.1 4006015 R 585034 CDS YP_002389232.1 218556318 7126588 4007734..4009602 1 NC_011741.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 4009602 trkD 7126588 trkD Escherichia coli IAI1 potassium transport protein Kup YP_002389232.1 4007734 D 585034 CDS YP_002389233.1 218556319 7127486 4009769..4010188 1 NC_011741.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 4010188 rbsD 7127486 rbsD Escherichia coli IAI1 D-ribose pyranase YP_002389233.1 4009769 D 585034 CDS YP_002389234.1 218556320 7126595 4010196..4011701 1 NC_011741.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP binding protein 4011701 rbsA 7126595 rbsA Escherichia coli IAI1 D-ribose transporter ATP binding protein YP_002389234.1 4010196 D 585034 CDS YP_002389235.1 218556321 7126592 4011706..4012671 1 NC_011741.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 4012671 rbsC 7126592 rbsC Escherichia coli IAI1 ribose ABC transporter permease YP_002389235.1 4011706 D 585034 CDS YP_002389236.1 218556322 7126594 4012696..4013586 1 NC_011741.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 4013586 rbsB 7126594 rbsB Escherichia coli IAI1 D-ribose transporter subunit RbsB YP_002389236.1 4012696 D 585034 CDS YP_002389237.1 218556323 7126593 4013712..4014641 1 NC_011741.1 catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 4014641 rbsK 7126593 rbsK Escherichia coli IAI1 ribokinase YP_002389237.1 4013712 D 585034 CDS YP_002389238.1 218556324 7126596 4014645..4015637 1 NC_011741.1 DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 4015637 rbsR 7126596 rbsR Escherichia coli IAI1 transcriptional repressor RbsR YP_002389238.1 4014645 D 585034 CDS YP_002389239.1 218556325 7126597 complement(4015603..4017030) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 20218988, 12107133; Product type t : transporter; multidrug or homocysteine efflux system 4017030 hsrA 7126597 hsrA Escherichia coli IAI1 multidrug or homocysteine efflux system YP_002389239.1 4015603 R 585034 CDS YP_002389240.1 218556326 7125317 complement(4017053..4017745) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4017745 yieP 7125317 yieP Escherichia coli IAI1 putative transcriptional regulator YP_002389240.1 4017053 R 585034 CDS YP_002389241.1 218556327 7128010 complement(4023544..4024383) 1 NC_011741.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR 4024383 hdfR 7128010 hdfR Escherichia coli IAI1 transcriptional regulator HdfR YP_002389241.1 4023544 R 585034 CDS YP_002389242.1 218556328 7128502 4024502..4024840 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4024840 yifE 7128502 yifE Escherichia coli IAI1 hypothetical protein YP_002389242.1 4024502 D 585034 CDS YP_002389243.1 218556329 7128181 complement(4024865..4026415) 1 NC_011741.1 among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function; putative ATP-dependent protease 4026415 yifB 7128181 yifB Escherichia coli IAI1 putative ATP-dependent protease YP_002389243.1 4024865 R 585034 CDS YP_002389244.1 218556330 7128180 4026738..4026836 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87174741; Product type l : leader peptide; ilvG operon leader peptide 4026836 ilvL 7128180 ilvL Escherichia coli IAI1 ilvG operon leader peptide YP_002389244.1 4026738 D 585034 CDS YP_002389245.1 218556331 7126058 4026976..4028622 1 NC_011741.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 4028622 ilvG 7126058 ilvG Escherichia coli IAI1 acetolactate synthase 2 catalytic subunit YP_002389245.1 4026976 D 585034 CDS YP_002389246.1 218556332 7126055 4028619..4028882 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92332418, 92380929, 1569580, 3550695, 3897211; Product type e : enzyme; acetolactate synthase 2 regulatory subunit 4028882 ilvM 7126055 ilvM Escherichia coli IAI1 acetolactate synthase 2 regulatory subunit YP_002389246.1 4028619 D 585034 CDS YP_002389247.1 218556333 7126059 4028902..4029831 1 NC_011741.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 4029831 ilvE 7126059 ilvE Escherichia coli IAI1 branched-chain amino acid aminotransferase YP_002389247.1 4028902 D 585034 CDS YP_002389248.1 218556334 7126054 4029896..4031746 1 NC_011741.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 4031746 ilvD 7126054 ilvD Escherichia coli IAI1 dihydroxy-acid dehydratase YP_002389248.1 4029896 D 585034 CDS YP_002389249.1 218556335 7126053 4031749..4033293 1 NC_011741.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 4033293 ilvA 7126053 ilvA Escherichia coli IAI1 threonine dehydratase YP_002389249.1 4031749 D 585034 CDS YP_002389250.1 218556336 7126050 complement(4033290..4034264) 1 NC_011741.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 4034264 ilvY 7126050 ilvY Escherichia coli IAI1 DNA-binding transcriptional regulator IlvY YP_002389250.1 4033290 R 585034 CDS YP_002389251.1 218556337 7126061 4034330..4035805 1 NC_011741.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 4035805 ilvC 7126061 ilvC Escherichia coli IAI1 ketol-acid reductoisomerase YP_002389251.1 4034330 D 585034 CDS YP_002389252.1 218556338 7126052 complement(4035892..4036173) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94215709, 7878732, 7925971, 8163020; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase C 4036173 ppiC 7126052 ppiC Escherichia coli IAI1 peptidyl-prolyl cis-trans isomerase C YP_002389252.1 4035892 R 585034 CDS YP_002389253.1 218556339 7126134 complement(4036372..4036863) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4036863 7126134 ECIAI1_3963 Escherichia coli IAI1 hypothetical protein YP_002389253.1 4036372 R 585034 CDS YP_002389254.1 218556340 7125649 4037038..4039059 1 NC_011741.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 4039059 rep 7125649 rep Escherichia coli IAI1 ATP-dependent DNA helicase Rep YP_002389254.1 4037038 D 585034 CDS YP_002389255.1 218556341 7124961 complement(4039106..4040590) 1 NC_011741.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase 4040590 gpp 7124961 gpp Escherichia coli IAI1 guanosine pentaphosphate phosphohydrolase YP_002389255.1 4039106 R 585034 CDS YP_002389256.1 218556342 7128460 complement(4040724..4041989) 1 NC_011741.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB 4041989 rhlB 7128460 rhlB Escherichia coli IAI1 ATP-dependent RNA helicase RhlB YP_002389256.1 4040724 R 585034 CDS YP_002389257.1 218556343 7124979 4042120..4042449 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202710, 91154193, 92250497, 99175138, 10489448, 1094461, 10947986, 1561103, 2181145, 2193685, 3891733, 4616096, 4883076, 6098320, 6099324, 7812718, 8098620, 8253691; Product type c : carrier; thioredoxin 4042449 trxA 7124979 trxA Escherichia coli IAI1 thioredoxin YP_002389257.1 4042120 D 585034 CDS YP_002389258.1 218556344 7127506 4042590..4042691 1 NC_011741.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; putative rho operon leader peptide 4042691 rhoL 7127506 rhoL Escherichia coli IAI1 putative rho operon leader peptide YP_002389258.1 4042590 D 585034 CDS YP_002389259.1 218556345 7124982 4042776..4044035 1 NC_011741.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 4044035 rho 7124982 rho Escherichia coli IAI1 transcription termination factor Rho YP_002389259.1 4042776 D 585034 CDS YP_002389260.1 218556346 7124981 4044045..4044263 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4044263 7124981 ECIAI1_3970 Escherichia coli IAI1 hypothetical protein YP_002389260.1 4044045 D 585034 CDS YP_002389261.1 218556347 7125650 4044275..4045378 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92114763, 94245613, 94292435, 10629198, 11024259, 11700352, 11832520, 1722555, 1730666; Product type e : enzyme; UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase 4045378 rfe 7125650 rfe Escherichia coli IAI1 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase YP_002389261.1 4044275 D 585034 CDS YP_002389262.1 218556348 7124964 4045390..4046436 1 NC_011741.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 4046436 wzzE 7124964 wzzE Escherichia coli IAI1 lipopolysaccharide biosynthesis protein WzzE YP_002389262.1 4045390 D 585034 CDS YP_002389263.1 218556349 7126466 4046492..4047622 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90212314, 90337949, 92112804, 94042873, 11106477, 7559340, 8170390, 8226648; Product type e : enzyme; UDP-N-acetyl glucosamine-2-epimerase 4047622 rffE 7126466 rffE Escherichia coli IAI1 UDP-N-acetyl glucosamine-2-epimerase YP_002389263.1 4046492 D 585034 CDS YP_002389264.1 218556350 7124968 4047619..4048881 1 NC_011741.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 4048881 wecC 7124968 wecC Escherichia coli IAI1 UDP-N-acetyl-D-mannosamine dehydrogenase YP_002389264.1 4047619 D 585034 CDS YP_002389265.1 218556351 7124967 4048881..4049948 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88086930, 90212314, 90337949, 92112804, 92174908, 94018634, 94042873, 7559340; Product type e : enzyme; dTDP-glucose 4,6-dehydratase 4049948 rffG 7124967 rffG Escherichia coli IAI1 dTDP-glucose 4,6-dehydratase YP_002389265.1 4048881 D 585034 CDS YP_002389266.1 218556352 7124969 4049967..4050848 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94292435, 96032389; Product type e : enzyme; glucose-1-phosphate thymidylyltransferase 4050848 rffH 7124969 rffH Escherichia coli IAI1 glucose-1-phosphate thymidylyltransferase YP_002389266.1 4049967 D 585034 CDS YP_002389267.1 218556353 7124970 4050826..4051500 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90212314, 90337949, 92112804, 8366065; Product type e : enzyme; TDP-fucosamine acetyltransferase 4051500 rffC 7124970 rffC Escherichia coli IAI1 TDP-fucosamine acetyltransferase YP_002389267.1 4050826 D 585034 CDS YP_002389268.1 218556354 7124966 4051505..4052635 1 NC_011741.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 4052635 rffA 7124966 rffA Escherichia coli IAI1 TDP-4-oxo-6-deoxy-D-glucose transaminase YP_002389268.1 4051505 D 585034 CDS YP_002389269.1 218556355 7124965 4052637..4053887 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12621029, 20044778; Product type t : transporter; O-antigen translocase 4053887 wzxE 7124965 wzxE Escherichia coli IAI1 O-antigen translocase YP_002389269.1 4052637 D 585034 CDS YP_002389270.1 218556356 7126464 4053884..4054963 1 NC_011741.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 4054963 rffT 7126464 rffT Escherichia coli IAI1 4-alpha-L-fucosyltransferase YP_002389270.1 4053884 D 585034 CDS YP_002389271.1 218556357 7124972 4054960..4056312 1 NC_011741.1 enterobacterial common antigen polymerase; putative common antigen polymerase 4056312 wzyE 7124972 wzyE Escherichia coli IAI1 putative common antigen polymerase YP_002389271.1 4054960 D 585034 CDS YP_002389272.1 218556358 7126465 4056315..4057055 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88086874, 90337949, 92112804; Product type e : enzyme; putative UDP-N-acetyl-D-mannosaminuronic acid transferase 4057055 rffM 7126465 rffM Escherichia coli IAI1 putative UDP-N-acetyl-D-mannosaminuronic acid transferase YP_002389272.1 4056315 D 585034 CDS YP_002389273.1 218556359 7124971 4057246..4058631 1 NC_011741.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; putative transport protein YifK 4058631 yifK 7124971 yifK Escherichia coli IAI1 putative transport protein YifK YP_002389273.1 4057246 D 585034 CDS YP_002389274.1 218556360 7128014 4059317..4060552 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11222759, 2180918, 12419807, 14749327; Product type pr : putative regulator; regulator of arylsulfatase activity 4060552 aslB 7128014 aslB Escherichia coli IAI1 regulator of arylsulfatase activity YP_002389274.1 4059317 D 585034 CDS YP_002389275.1 218556361 7124665 complement(4061476..4062672) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 89041586; Product type pe : putative enzyme; putative protoheme IX biogenesis protein 4062672 hemY 7124665 hemY Escherichia coli IAI1 putative protoheme IX biogenesis protein YP_002389275.1 4061476 R 585034 CDS YP_002389276.1 218556362 7128516 complement(4062675..4063898) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 89098348, 92358234, 3054815, 3062586, 9298646; Product type pe : putative enzyme; putative uroporphyrinogen III C-methyltransferase 4063898 hemX 7128516 hemX Escherichia coli IAI1 putative uroporphyrinogen III C-methyltransferase YP_002389276.1 4062675 R 585034 CDS YP_002389277.1 218556363 7128515 complement(4063920..4064660) 1 NC_011741.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 4064660 hemD 7128515 hemD Escherichia coli IAI1 uroporphyrinogen-III synthase YP_002389277.1 4063920 R 585034 CDS YP_002389278.1 218556364 7128508 complement(4064657..4065598) 1 NC_011741.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 4065598 hemC 7128508 hemC Escherichia coli IAI1 porphobilinogen deaminase YP_002389278.1 4064657 R 585034 CDS YP_002389279.1 218556365 7128507 4065985..4068531 1 NC_011741.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 4068531 cyaA 7128507 cyaA Escherichia coli IAI1 adenylate cyclase YP_002389279.1 4065985 D 585034 CDS YP_002389280.1 218556366 7126869 complement(4068571..4068891) 1 NC_011741.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 4068891 cyaY 7126869 cyaY Escherichia coli IAI1 frataxin-like protein YP_002389280.1 4068571 R 585034 CDS YP_002389281.1 218556367 7126870 complement(4068939..4070252) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4070252 7126870 ECIAI1_3995 Escherichia coli IAI1 hypothetical protein YP_002389281.1 4068939 R 585034 CDS YP_002389282.1 218556368 7125651 complement(4070249..4071757) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4071757 7125651 ECIAI1_3996 Escherichia coli IAI1 hypothetical protein YP_002389282.1 4070249 R 585034 CDS YP_002389283.1 218556369 7125652 complement(4072095..4072649) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4072649 7125652 ECIAI1_3997 Escherichia coli IAI1 hypothetical protein YP_002389283.1 4072095 R 585034 CDS YP_002389284.1 218556370 7125653 complement(4072656..4072790) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 4072790 7125653 ECIAI1_3998 Escherichia coli IAI1 hypothetical protein YP_002389284.1 4072656 R 585034 CDS YP_002389285.1 218556371 7125654 4072999..4073202 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 4073202 yifL 7125654 yifL Escherichia coli IAI1 hypothetical protein YP_002389285.1 4072999 D 585034 CDS YP_002389286.1 218556372 7128183 4073239..4074063 1 NC_011741.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 4074063 dapF 7128183 dapF Escherichia coli IAI1 diaminopimelate epimerase YP_002389286.1 4073239 D 585034 CDS YP_002389287.1 218556373 7126920 4074060..4074767 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4074767 yigA 7126920 yigA Escherichia coli IAI1 hypothetical protein YP_002389287.1 4074060 D 585034 CDS YP_002389288.1 218556374 7128184 4074764..4075660 1 NC_011741.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 4075660 xerC 7128184 xerC Escherichia coli IAI1 site-specific tyrosine recombinase XerC YP_002389288.1 4074764 D 585034 CDS YP_002389289.1 218556375 7126471 4075660..4076376 1 NC_011741.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 4076376 yigB 7126471 yigB Escherichia coli IAI1 flavin mononucleotide phosphatase YP_002389289.1 4075660 D 585034 CDS YP_002389290.1 218556376 7128185 4076460..4078622 1 NC_011741.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 4078622 uvrD 7128185 uvrD Escherichia coli IAI1 DNA-dependent helicase II YP_002389290.1 4076460 D 585034 CDS YP_002389291.1 218556377 7125558 complement(4078769..4079533) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4079533 yigE 7125558 yigE Escherichia coli IAI1 hypothetical protein YP_002389291.1 4078769 R 585034 CDS YP_002389292.1 218556378 7128186 4079903..4080853 1 NC_011741.1 responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 4080853 corA 7128186 corA Escherichia coli IAI1 magnesium/nickel/cobalt transporter CorA YP_002389292.1 4079903 D 585034 CDS YP_002389293.1 218556379 7126353 complement(4080907..4081386) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4081386 7126353 ECIAI1_4007 Escherichia coli IAI1 hypothetical protein YP_002389293.1 4080907 R 585034 CDS YP_002389294.1 218556380 7125655 complement(4081383..4082237) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4082237 7125655 ECIAI1_4008 Escherichia coli IAI1 hypothetical protein YP_002389294.1 4081383 R 585034 CDS YP_002389295.1 218556381 7125656 4082361..4082564 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4082564 7125656 ECIAI1_4009 Escherichia coli IAI1 hypothetical protein YP_002389295.1 4082361 D 585034 CDS YP_002389296.1 218556382 7125657 complement(4082589..4082867) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4082867 7125657 ECIAI1_4010 Escherichia coli IAI1 hypothetical protein YP_002389296.1 4082589 R 585034 CDS YP_002389297.1 218556383 7125658 4083145..4083489 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4083489 7125658 ECIAI1_4011 Escherichia coli IAI1 hypothetical protein YP_002389297.1 4083145 D 585034 CDS YP_002389298.1 218556384 7125659 complement(4083536..4084423) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative chloramphenicol resistance permease 4084423 rarD 7125659 rarD Escherichia coli IAI1 putative chloramphenicol resistance permease YP_002389298.1 4083536 R 585034 CDS YP_002389299.1 218556385 7126587 complement(4084475..4084942) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4084942 yigI 7126587 yigI Escherichia coli IAI1 hypothetical protein YP_002389299.1 4084475 R 585034 CDS YP_002389300.1 218556386 7128187 4085107..4085976 1 NC_011741.1 catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 4085976 pldA 7128187 pldA Escherichia coli IAI1 phospholipase A YP_002389300.1 4085107 D 585034 CDS YP_002389301.1 218556387 7126097 4086109..4087938 1 NC_011741.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ 4087938 recQ 7126097 recQ Escherichia coli IAI1 ATP-dependent DNA helicase RecQ YP_002389301.1 4086109 D 585034 CDS YP_002389302.1 218556388 7124954 4088002..4088622 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99313167, 10386596, 3027506; Product type t : transporter; threonine efflux system 4088622 rhtC 7124954 rhtC Escherichia coli IAI1 threonine efflux system YP_002389302.1 4088002 D 585034 CDS YP_002389303.1 218556389 7124991 complement(4088684..4089304) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99313167, 10386596; Product type t : transporter; homoserine/homoserine lactone efflux protein 4089304 rhtB 7124991 rhtB Escherichia coli IAI1 homoserine/homoserine lactone efflux protein YP_002389303.1 4088684 R 585034 CDS YP_002389304.1 218556390 7124990 4089303..4089488 1 NC_011741.1 hypothetical protein 4089488 7124990 ECIAI1_4019 Escherichia coli IAI1 hypothetical protein YP_002389304.1 4089303 D 585034 CDS YP_002389305.1 218556391 7125660 4089415..4090437 1 NC_011741.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 4090437 pldB 7125660 pldB Escherichia coli IAI1 lysophospholipase L2 YP_002389305.1 4089415 D 585034 CDS YP_002389306.1 218556392 7126098 4090445..4091245 1 NC_011741.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; putative sugar phosphatase 4091245 yigL 7126098 yigL Escherichia coli IAI1 putative sugar phosphatase YP_002389306.1 4090445 D 585034 CDS YP_002389307.1 218556393 7128188 4091321..4092220 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4092220 yigM 7128188 yigM Escherichia coli IAI1 hypothetical protein YP_002389307.1 4091321 D 585034 CDS YP_002389308.1 218556394 7128189 complement(4092108..4093061) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90384950, 96303520, 2205852, 2643109; Product type r : regulator; DNA-binding transcriptional activator, homocysteine-binding 4093061 metR 7128189 metR Escherichia coli IAI1 DNA-binding transcriptional activator, homocysteine-binding YP_002389308.1 4092108 R 585034 CDS YP_002389309.1 218556395 7124255 4093179..4095440 1 NC_011741.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 4095440 metE 7124255 metE Escherichia coli IAI1 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase YP_002389309.1 4093179 D 585034 CDS YP_002389310.1 218556396 7124245 complement(4095479..4096294) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12676709; Product type pe : putative enzyme; putative hydrolase 4096294 ysgA 7124245 ysgA Escherichia coli IAI1 putative hydrolase YP_002389310.1 4095479 R 585034 CDS YP_002389311.1 218556397 7128105 4096556..4097317 1 NC_011741.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 4097317 udp 7128105 udp Escherichia coli IAI1 uridine phosphorylase YP_002389311.1 4096556 D 585034 CDS YP_002389312.1 218556398 7125520 4097458..4098885 1 NC_011741.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 4098885 rmuC 7125520 rmuC Escherichia coli IAI1 DNA recombination protein RmuC YP_002389312.1 4097458 D 585034 CDS YP_002389313.1 218556399 7125014 4098980..4099735 1 NC_011741.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 4099735 ubiE 7125014 ubiE Escherichia coli IAI1 ubiquinone/menaquinone biosynthesis methyltransferase YP_002389313.1 4098980 D 585034 CDS YP_002389314.1 218556400 7125513 4099749..4100354 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4100354 yigP 7125513 yigP Escherichia coli IAI1 hypothetical protein YP_002389314.1 4099749 D 585034 CDS YP_002389315.1 218556401 7128190 4100351..4101991 1 NC_011741.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; putative ubiquinone biosynthesis protein UbiB 4101991 ubiB 7128190 ubiB Escherichia coli IAI1 putative ubiquinone biosynthesis protein UbiB YP_002389315.1 4100351 D 585034 CDS YP_002389316.1 218556402 7125510 4102070..4102339 1 NC_011741.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A 4102339 tatA 7125510 tatA Escherichia coli IAI1 twin arginine translocase protein A YP_002389316.1 4102070 D 585034 CDS YP_002389317.1 218556403 7126214 4102343..4102858 1 NC_011741.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 4102858 tatB 7126214 tatB Escherichia coli IAI1 sec-independent translocase YP_002389317.1 4102343 D 585034 CDS YP_002389318.1 218556404 7126215 4102861..4103637 1 NC_011741.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 4103637 tatC 7126215 tatC Escherichia coli IAI1 twin-arginine protein translocation system subunit TatC YP_002389318.1 4102861 D 585034 CDS YP_002389319.1 218556405 7126216 4103679..4104461 1 NC_011741.1 magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD 4104461 tatD 7126216 tatD Escherichia coli IAI1 DNase TatD YP_002389319.1 4103679 D 585034 CDS YP_002389320.1 218556406 7126217 complement(4104458..4104946) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92011415, 92250420, 92261317, 1584020, 12007406; Product type r : regulator; transcriptional activator RfaH 4104946 rfaH 7126217 rfaH Escherichia coli IAI1 transcriptional activator RfaH YP_002389320.1 4104458 R 585034 CDS YP_002389321.1 218556407 7124963 4105113..4106606 1 NC_011741.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate decarboxylase 4106606 ubiD 7124963 ubiD Escherichia coli IAI1 3-octaprenyl-4-hydroxybenzoate decarboxylase YP_002389321.1 4105113 D 585034 CDS YP_002389322.1 218556408 7125512 4106652..4107353 1 NC_011741.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 4107353 fre 7125512 fre Escherichia coli IAI1 FMN reductase YP_002389322.1 4106652 D 585034 CDS YP_002389323.1 218556409 7127274 complement(4107545..4108708) 1 NC_011741.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase 4108708 fadA 7127274 fadA Escherichia coli IAI1 3-ketoacyl-CoA thiolase YP_002389323.1 4107545 R 585034 CDS YP_002389324.1 218556410 7127061 complement(4108718..4110907) 1 NC_011741.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha 4110907 fadB 7127061 fadB Escherichia coli IAI1 multifunctional fatty acid oxidation complex subunit alpha YP_002389324.1 4108718 R 585034 CDS YP_002389325.1 218556411 7127062 4111097..4112428 1 NC_011741.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 4112428 pepQ 7127062 pepQ Escherichia coli IAI1 proline dipeptidase YP_002389325.1 4111097 D 585034 CDS YP_002389326.1 218556412 7124175 4112428..4113042 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15103642; Product type pf : putative factor; hypothetical protein 4113042 yigZ 7124175 yigZ Escherichia coli IAI1 hypothetical protein YP_002389326.1 4112428 D 585034 CDS YP_002389327.1 218556413 7128191 4113081..4114532 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100357, 2243799, 7896723; Product type t : transporter; potassium transporter 4114532 trkH 7128191 trkH Escherichia coli IAI1 potassium transporter YP_002389327.1 4113081 D 585034 CDS YP_002389328.1 218556414 7127487 4114544..4115089 1 NC_011741.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 4115089 hemG 7127487 hemG Escherichia coli IAI1 protoporphyrinogen oxidase YP_002389328.1 4114544 D 585034 CDS YP_002389329.1 218556415 7125485 complement(4120671..4121183) 1 NC_011741.1 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; molybdopterin-guanine dinucleotide biosynthesis protein B 4121183 mobB 7125485 mobB Escherichia coli IAI1 molybdopterin-guanine dinucleotide biosynthesis protein B YP_002389329.1 4120671 R 585034 CDS YP_002389330.1 218556416 7124296 complement(4121180..4121764) 1 NC_011741.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA 4121764 mobA 7124296 mobA Escherichia coli IAI1 molybdopterin-guanine dinucleotide biosynthesis protein MobA YP_002389330.1 4121180 R 585034 CDS YP_002389331.1 218556417 7124295 4121834..4122103 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4122103 yihD 7124295 yihD Escherichia coli IAI1 hypothetical protein YP_002389331.1 4121834 D 585034 CDS YP_002389332.1 218556418 7128193 4122180..4123166 1 NC_011741.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 4123166 yihE 7128193 yihE Escherichia coli IAI1 serine/threonine protein kinase YP_002389332.1 4122180 D 585034 CDS YP_002389333.1 218556419 7128194 4123183..4123809 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12498799, 93264419, 94016574, 94206930, 99298180, 10210188, 1429594, 1740115, 1934062, 8413591, 8494885, 8521518, 9194175, 9298646, 9300489, 9572841, 9600841, 9655827; Product type e : enzyme; periplasmic protein disulfide isomerase I 4123809 dsbA 7128194 dsbA Escherichia coli IAI1 periplasmic protein disulfide isomerase I YP_002389333.1 4123183 D 585034 CDS YP_002389334.1 218556420 7124622 4123964..4125394 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4125394 yihF 7124622 yihF Escherichia coli IAI1 hypothetical protein YP_002389334.1 4123964 D 585034 CDS YP_002389335.1 218556421 7128195 complement(4125435..4126367) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyltransferase 4126367 yihG 7128195 yihG Escherichia coli IAI1 putative acyltransferase YP_002389335.1 4125435 R 585034 CDS YP_002389336.1 218556422 7128196 4126731..4129517 1 NC_011741.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 4129517 polA 7128196 polA Escherichia coli IAI1 DNA polymerase I YP_002389336.1 4126731 D 585034 CDS YP_002389337.1 218556423 7127961 complement(4129736..4129885) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4129885 7127961 ECIAI1_4063 Escherichia coli IAI1 hypothetical protein YP_002389337.1 4129736 R 585034 CDS YP_002389338.1 218556424 7125661 complement(4129899..4130495) 1 NC_011741.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 4130495 engB 7125661 engB Escherichia coli IAI1 ribosome biogenesis GTP-binding protein YsxC YP_002389338.1 4129899 R 585034 CDS YP_002389339.1 218556425 7126854 4131113..4131622 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4131622 yihI 7126854 yihI Escherichia coli IAI1 hypothetical protein YP_002389339.1 4131113 D 585034 CDS YP_002389340.1 218556426 7128197 4131811..4133184 1 NC_011741.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4133184 hemN 7128197 hemN Escherichia coli IAI1 coproporphyrinogen III oxidase YP_002389340.1 4131811 D 585034 CDS YP_002389341.1 218556427 7128514 complement(4133596..4135005) 1 NC_011741.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) 4135005 glnG 7128514 glnG Escherichia coli IAI1 nitrogen regulation protein NR(I) YP_002389341.1 4133596 R 585034 CDS YP_002389342.1 218556428 7128325 complement(4135017..4136066) 1 NC_011741.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) 4136066 glnL 7128325 glnL Escherichia coli IAI1 nitrogen regulation protein NR(II) YP_002389342.1 4135017 R 585034 CDS YP_002389343.1 218556429 7128328 complement(4136385..4137794) 1 NC_011741.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase 4137794 glnA 7128328 glnA Escherichia coli IAI1 glutamine synthetase YP_002389343.1 4136385 R 585034 CDS YP_002389344.1 218556430 7128321 complement(4137922..4138074) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4138074 7128321 ECIAI1_4070 Escherichia coli IAI1 hypothetical protein YP_002389344.1 4137922 R 585034 CDS YP_002389345.1 218556431 7125662 4138167..4139990 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9642082, 7783627, 9298646, 9622352; Product type f : factor; GTP-binding protein 4139990 bipA 7125662 bipA Escherichia coli IAI1 GTP-binding protein YP_002389345.1 4138167 D 585034 CDS YP_002389346.1 218556432 7124413 4140207..4140917 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4140917 yihL 7124413 yihL Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002389346.1 4140207 D 585034 CDS YP_002389347.1 218556433 7128198 4140925..4141905 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar phosphate isomerase 4141905 yihM 7128198 yihM Escherichia coli IAI1 putative sugar phosphate isomerase YP_002389347.1 4140925 D 585034 CDS YP_002389348.1 218556434 7128199 4142007..4143272 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4143272 yihN 7128199 yihN Escherichia coli IAI1 putative transporter YP_002389348.1 4142007 D 585034 CDS YP_002389349.1 218556435 7128200 complement(4143363..4144055) 1 NC_011741.1 porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown; outer membrane porin L 4144055 ompL 7128200 ompL Escherichia coli IAI1 outer membrane porin L YP_002389349.1 4143363 R 585034 CDS YP_002389350.1 218556436 7125982 complement(4144123..4145526) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4145526 yihO 7125982 yihO Escherichia coli IAI1 putative transporter YP_002389350.1 4144123 R 585034 CDS YP_002389351.1 218556437 7128201 complement(4145569..4146975) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4146975 yihP 7128201 yihP Escherichia coli IAI1 putative transporter YP_002389351.1 4145569 R 585034 CDS YP_002389352.1 218556438 7128202 complement(4147000..4149036) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15294295; Product type e : enzyme; alpha-glucosidase 4149036 yihQ 7128202 yihQ Escherichia coli IAI1 alpha-glucosidase YP_002389352.1 4147000 R 585034 CDS YP_002389353.1 218556439 7128203 complement(4149235..4150161) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldose-1-epimerase 4150161 yihR 7128203 yihR Escherichia coli IAI1 putative aldose-1-epimerase YP_002389353.1 4149235 R 585034 CDS YP_002389354.1 218556440 7128204 complement(4150275..4151516) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glucosamine isomerase 4151516 yihS 7128204 yihS Escherichia coli IAI1 putative glucosamine isomerase YP_002389354.1 4150275 R 585034 CDS YP_002389355.1 218556441 7128205 complement(4151533..4152411) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldolase 4152411 yihT 7128205 yihT Escherichia coli IAI1 putative aldolase YP_002389355.1 4151533 R 585034 CDS YP_002389356.1 218556442 7128206 complement(4152435..4153331) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 4153331 yihU 7128206 yihU Escherichia coli IAI1 putative oxidoreductase YP_002389356.1 4152435 R 585034 CDS YP_002389357.1 218556443 7128207 4153499..4154395 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar kinase 4154395 yihV 7128207 yihV Escherichia coli IAI1 putative sugar kinase YP_002389357.1 4153499 D 585034 CDS YP_002389358.1 218556444 7128208 4154429..4155214 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4155214 yihW 7128208 yihW Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002389358.1 4154429 D 585034 CDS YP_002389359.1 218556445 7128209 4155313..4155912 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; phosphatase 4155912 yihX 7128209 yihX Escherichia coli IAI1 phosphatase YP_002389359.1 4155313 D 585034 CDS YP_002389360.1 218556446 7128210 4155906..4156778 1 NC_011741.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 4156778 rbn 7128210 rbn Escherichia coli IAI1 ribonuclease BN YP_002389360.1 4155906 D 585034 CDS YP_002389361.1 218556447 7126591 4156775..4157212 1 NC_011741.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 4157212 dtd 7126591 dtd Escherichia coli IAI1 D-tyrosyl-tRNA(Tyr) deacylase YP_002389361.1 4156775 D 585034 CDS YP_002389362.1 218556448 7125031 4157209..4158198 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase 4158198 yiiD 7125031 yiiD Escherichia coli IAI1 putative acetyltransferase YP_002389362.1 4157209 D 585034 CDS YP_002389363.1 218556449 7128211 complement(4158262..4159245) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative lipase 4159245 7128211 ECIAI1_4089 Escherichia coli IAI1 putative lipase YP_002389363.1 4158262 R 585034 CDS YP_002389364.1 218556450 7125663 4159399..4159710 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4159710 7125663 ECIAI1_4090 Escherichia coli IAI1 hypothetical protein YP_002389364.1 4159399 D 585034 CDS YP_002389365.1 218556451 7125664 4159711..4160001 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4160001 7125664 ECIAI1_4091 Escherichia coli IAI1 hypothetical protein YP_002389365.1 4159711 D 585034 CDS YP_002389366.1 218556452 7125665 4160606..4160824 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4160824 yiiE 7125665 yiiE Escherichia coli IAI1 putative transcriptional regulator YP_002389366.1 4160606 D 585034 CDS YP_002389367.1 218556453 7128212 4161067..4161285 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4161285 yiiF 7128212 yiiF Escherichia coli IAI1 hypothetical protein YP_002389367.1 4161067 D 585034 CDS YP_002389368.1 218556454 7128213 complement(4161615..4162544) 1 NC_011741.1 required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 4162544 fdhE 7128213 fdhE Escherichia coli IAI1 formate dehydrogenase accessory protein FdhE YP_002389368.1 4161615 R 585034 CDS YP_002389369.1 218556455 7127073 complement(4162541..4163176) 1 NC_011741.1 cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma 4163176 fdoI 7127073 fdoI Escherichia coli IAI1 formate dehydrogenase-O subunit gamma YP_002389369.1 4162541 R 585034 CDS YP_002389370.1 218556456 7127080 complement(4163173..4164075) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91317715, 8522521, 9852007; Product type c : carrier; formate dehydrogenase-O, Fe-S subunit 4164075 fdoH 7127080 fdoH Escherichia coli IAI1 formate dehydrogenase-O, Fe-S subunit YP_002389370.1 4163173 R 585034 CDS YP_002389371.1 218556457 7127079 complement(4164088..4167138) 1 NC_011741.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-O, large subunit 4167138 fdoG 7127079 fdoG Escherichia coli IAI1 formate dehydrogenase-O, large subunit YP_002389371.1 4164088 R 585034 CDS YP_002389372.1 218556458 7127078 4167332..4168165 1 NC_011741.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 4168165 fdhD 7127078 fdhD Escherichia coli IAI1 formate dehydrogenase accessory protein YP_002389372.1 4167332 D 585034 CDS YP_002389373.1 218556459 7127072 4168318..4169358 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4169358 yiiG 7127072 yiiG Escherichia coli IAI1 hypothetical protein YP_002389373.1 4168318 D 585034 CDS YP_002389374.1 218556460 7128214 complement(4169408..4171156) 1 NC_011741.1 putative repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system; putative frv operon regulatory protein 4171156 frvR 7128214 frvR Escherichia coli IAI1 putative frv operon regulatory protein YP_002389374.1 4169408 R 585034 CDS YP_002389375.1 218556461 7128223 complement(4171156..4172226) 1 NC_011741.1 with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars; putative fructose-specific phosphotransferase system protein FrvX 4172226 frvX 7128223 frvX Escherichia coli IAI1 putative fructose-specific phosphotransferase system protein FrvX YP_002389375.1 4171156 R 585034 CDS YP_002389376.1 218556462 7128224 complement(4172216..4173667) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 94290319; Product type t : transporter; putative PTS system transporter subunits IIBC 4173667 frvB 7128224 frvB Escherichia coli IAI1 putative PTS system transporter subunits IIBC YP_002389376.1 4172216 R 585034 CDS YP_002389377.1 218556463 7128222 complement(4173678..4174124) 1 NC_011741.1 with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system; putative fructose-like phosphotransferase system subunit EIIA 4174124 frvA 7128222 frvA Escherichia coli IAI1 putative fructose-like phosphotransferase system subunit EIIA YP_002389377.1 4173678 R 585034 CDS YP_002389378.1 218556464 7128221 complement(4174437..4174751) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15060078; Product type e : enzyme; L-rhamnose mutarotase 4174751 yiiL 7128221 yiiL Escherichia coli IAI1 L-rhamnose mutarotase YP_002389378.1 4174437 R 585034 CDS YP_002389379.1 218556465 7128215 complement(4174761..4175585) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90128204, 93374854, 8396120; Product type e : enzyme; rhamnulose-1-phosphate aldolase 4175585 rhaD 7128215 rhaD Escherichia coli IAI1 rhamnulose-1-phosphate aldolase YP_002389379.1 4174761 R 585034 CDS YP_002389380.1 218556466 7124975 complement(4175827..4177086) 1 NC_011741.1 catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase 4177086 rhaA 7124975 rhaA Escherichia coli IAI1 L-rhamnose isomerase YP_002389380.1 4175827 R 585034 CDS YP_002389381.1 218556467 7124973 complement(4177083..4178552) 1 NC_011741.1 catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase 4178552 rhaB 7124973 rhaB Escherichia coli IAI1 rhamnulokinase YP_002389381.1 4177083 R 585034 CDS YP_002389382.1 218556468 7124974 4178840..4179676 1 NC_011741.1 activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 4179676 rhaS 7124974 rhaS Escherichia coli IAI1 transcriptional activator RhaS YP_002389382.1 4178840 D 585034 CDS YP_002389383.1 218556469 7124977 4179660..4180598 1 NC_011741.1 activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR 4180598 rhaR 7124977 rhaR Escherichia coli IAI1 transcriptional activator RhaR YP_002389383.1 4179660 D 585034 CDS YP_002389384.1 218556470 7124976 complement(4180595..4181629) 1 NC_011741.1 transports L-rhamnose and L-lyxose into the cell; rhamnose-proton symporter 4181629 rhaT 7124976 rhaT Escherichia coli IAI1 rhamnose-proton symporter YP_002389384.1 4180595 R 585034 CDS YP_002389385.1 218556471 7124978 4181914..4182534 1 NC_011741.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 4182534 sodA 7124978 sodA Escherichia coli IAI1 superoxide dismutase YP_002389385.1 4181914 D 585034 CDS YP_002389386.1 218556472 7127941 4182794..4183777 1 NC_011741.1 transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 4183777 kdgT 7127941 kdgT Escherichia coli IAI1 2-keto-3-deoxygluconate permease YP_002389386.1 4182794 D 585034 CDS YP_002389387.1 218556473 7126372 4183926..4184600 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4184600 yiiM 7126372 yiiM Escherichia coli IAI1 hypothetical protein YP_002389387.1 4183926 D 585034 CDS YP_002389388.1 218556474 7128216 complement(4184706..4186079) 1 NC_011741.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein 4186079 cpxA 7128216 cpxA Escherichia coli IAI1 two-component sensor protein YP_002389388.1 4184706 R 585034 CDS YP_002389389.1 218556475 7126360 complement(4186076..4186774) 1 NC_011741.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR 4186774 cpxR 7126360 cpxR Escherichia coli IAI1 DNA-binding transcriptional regulator CpxR YP_002389389.1 4186076 R 585034 CDS YP_002389390.1 218556476 7126362 4186924..4187424 1 NC_011741.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; periplasmic repressor CpxP 4187424 cpxP 7126362 cpxP Escherichia coli IAI1 periplasmic repressor CpxP YP_002389390.1 4186924 D 585034 CDS YP_002389391.1 218556477 7126361 4187573..4188475 1 NC_011741.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F 4188475 fieF 7126361 fieF Escherichia coli IAI1 ferrous iron efflux protein F YP_002389391.1 4187573 D 585034 CDS YP_002389392.1 218556478 7127107 4188656..4189618 1 NC_011741.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 4189618 pfkA 7127107 pfkA Escherichia coli IAI1 6-phosphofructokinase YP_002389392.1 4188656 D 585034 CDS YP_002389393.1 218556479 7124178 4189937..4190926 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91161616, 2002055, 3158524, 8774726, 9298646; Product type t : transporter; sulfate transporter subunit 4190926 sbp 7124178 sbp Escherichia coli IAI1 sulfate transporter subunit YP_002389393.1 4189937 D 585034 CDS YP_002389394.1 218556480 7124680 4191033..4191788 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86008270, 2995360, 3158524; Product type e : enzyme; CDP-diacylglycerol pyrophosphatase 4191788 cdh 7124680 cdh Escherichia coli IAI1 CDP-diacylglycerol pyrophosphatase YP_002389394.1 4191033 D 585034 CDS YP_002389395.1 218556481 7126296 complement(4191843..4192610) 1 NC_011741.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 4192610 tpiA 7126296 tpiA Escherichia coli IAI1 triosephosphate isomerase YP_002389395.1 4191843 R 585034 CDS YP_002389396.1 218556482 7127475 complement(4192718..4193317) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4193317 yiiQ 7127475 yiiQ Escherichia coli IAI1 hypothetical protein YP_002389396.1 4192718 R 585034 CDS YP_002389397.1 218556483 7128217 4193418..4193858 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4193858 yiiR 7128217 yiiR Escherichia coli IAI1 hypothetical protein YP_002389397.1 4193418 D 585034 CDS YP_002389398.1 218556484 7124379 4194070..4194369 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4194369 yiiS 7124379 yiiS Escherichia coli IAI1 hypothetical protein YP_002389398.1 4194070 D 585034 CDS YP_002389399.1 218556485 7125348 4194396..4194824 1 NC_011741.1 with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 4194824 yiiT 7125348 yiiT Escherichia coli IAI1 universal stress protein UspD YP_002389399.1 4194396 D 585034 CDS YP_002389400.1 218556486 7125349 complement(4194829..4195575) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93194782, 94092163, 95050480, 95362685, 1400248, 2834327, 7961651, 8449868, 9149148; Product type e : enzyme; ferredoxin-NADP reductase 4195575 fpr 7125349 fpr Escherichia coli IAI1 ferredoxin-NADP reductase YP_002389400.1 4194829 R 585034 CDS YP_002389401.1 218556487 7127268 complement(4195672..4196682) 1 NC_011741.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 4196682 glpX 7127268 glpX Escherichia coli IAI1 fructose 1,6-bisphosphatase II YP_002389401.1 4195672 R 585034 CDS YP_002389402.1 218556488 7128345 complement(4196818..4198326) 1 NC_011741.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 4198326 glpK 7128345 glpK Escherichia coli IAI1 glycerol kinase YP_002389402.1 4196818 R 585034 CDS YP_002389403.1 218556489 7128341 complement(4198349..4199194) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12629974, 12948772, 14646142, 15004242, 90094250, 92210584, 11039922, 11101882, 11226336, 11964478, 1372899, 2544860, 6998951; Product type t : transporter; glycerol facilitator 4199194 glpF 7128341 glpF Escherichia coli IAI1 glycerol facilitator YP_002389403.1 4198349 R 585034 CDS YP_002389404.1 218556490 7128339 4199620..4199865 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4199865 yiiU 7128339 yiiU Escherichia coli IAI1 hypothetical protein YP_002389404.1 4199620 D 585034 CDS YP_002389405.1 218556491 7125350 complement(4199950..4200435) 1 NC_011741.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 4200435 rraA 7125350 rraA Escherichia coli IAI1 ribonuclease activity regulator protein RraA YP_002389405.1 4199950 R 585034 CDS YP_002389406.1 218556492 7128428 complement(4200528..4201454) 1 NC_011741.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 4201454 menA 7128428 menA Escherichia coli IAI1 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_002389406.1 4200528 R 585034 CDS YP_002389407.1 218556493 7124235 complement(4201521..4202852) 1 NC_011741.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 4202852 hslU 7124235 hslU Escherichia coli IAI1 ATP-dependent protease ATP-binding subunit HslU YP_002389407.1 4201521 R 585034 CDS YP_002389408.1 218556494 7125315 complement(4202862..4203392) 1 NC_011741.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 4203392 hslV 7125315 hslV Escherichia coli IAI1 ATP-dependent protease peptidase subunit YP_002389408.1 4202862 R 585034 CDS YP_002389409.1 218556495 7125316 complement(4203485..4204444) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9282742, 93285993, 8509333; Product type cp : cell process; essential cell division protein FtsN 4204444 ftsN 7125316 ftsN Escherichia coli IAI1 essential cell division protein FtsN YP_002389409.1 4203485 R 585034 CDS YP_002389410.1 218556496 7128239 complement(4204536..4205561) 1 NC_011741.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR 4205561 cytR 7128239 cytR Escherichia coli IAI1 DNA-binding transcriptional regulator CytR YP_002389410.1 4204536 R 585034 CDS YP_002389411.1 218556497 7126905 complement(4205717..4207915) 1 NC_011741.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 4207915 priA 7126905 priA Escherichia coli IAI1 primosome assembly protein PriA YP_002389411.1 4205717 R 585034 CDS YP_002389412.1 218556498 7126148 4208118..4208330 1 NC_011741.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 4208330 rpmE 7126148 rpmE Escherichia coli IAI1 50S ribosomal protein L31 YP_002389412.1 4208118 D 585034 CDS YP_002389413.1 218556499 7126068 complement(4213904..4214512) 1 NC_011741.1 member of the NlpC/P60 superfamily of peptidases; putative peptidoglycan peptidase 4214512 yiiX 7126068 yiiX Escherichia coli IAI1 putative peptidoglycan peptidase YP_002389413.1 4213904 R 585034 CDS YP_002389414.1 218556500 7125351 complement(4214572..4214889) 1 NC_011741.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ 4214889 metJ 7125351 metJ Escherichia coli IAI1 transcriptional repressor protein MetJ YP_002389414.1 4214572 R 585034 CDS YP_002389415.1 218556501 7124250 4215166..4216326 1 NC_011741.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 4216326 metB 7124250 metB Escherichia coli IAI1 cystathionine gamma-synthase YP_002389415.1 4215166 D 585034 CDS YP_002389416.1 218556502 7124243 4216329..4218761 1 NC_011741.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 4218761 metL 7124243 metL Escherichia coli IAI1 bifunctional aspartate kinase II/homoserine dehydrogenase II YP_002389416.1 4216329 D 585034 CDS YP_002389417.1 218556503 7124252 4219110..4220000 1 NC_011741.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 4220000 metF 7124252 metF Escherichia coli IAI1 5,10-methylenetetrahydrofolate reductase YP_002389417.1 4219110 D 585034 CDS YP_002389418.1 218556504 7124246 4220329..4222509 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90292022, 94209230, 3045098; Product type e : enzyme; catalase/hydroperoxidase HPI(I) 4222509 katG 7124246 katG Escherichia coli IAI1 catalase/hydroperoxidase HPI(I) YP_002389418.1 4220329 D 585034 CDS YP_002389419.1 218556505 7126093 4222603..4223508 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease 4223508 yijE 7126093 yijE Escherichia coli IAI1 putative permease YP_002389419.1 4222603 D 585034 CDS YP_002389420.1 218556506 7125353 complement(4223535..4224152) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4224152 yijF 7125353 yijF Escherichia coli IAI1 hypothetical protein YP_002389420.1 4223535 R 585034 CDS YP_002389421.1 218556507 7125354 complement(4224427..4225530) 1 NC_011741.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 4225530 gldA 7125354 gldA Escherichia coli IAI1 glycerol dehydrogenase YP_002389421.1 4224427 R 585034 CDS YP_002389422.1 218556508 7128310 complement(4225541..4226203) 1 NC_011741.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 4226203 fsaB 7128310 fsaB Escherichia coli IAI1 fructose-6-phosphate aldolase YP_002389422.1 4225541 R 585034 CDS YP_002389423.1 218556509 7128229 complement(4226215..4228716) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 95291446, 7773398; Product type t : transporter; putative PTS enzymes Hpr component/ enzyme I component/ enzyme IIA component 4228716 ptsA 7128229 ptsA Escherichia coli IAI1 putative PTS enzymes Hpr component/ enzyme I component/ enzyme IIA component YP_002389423.1 4226215 R 585034 CDS YP_002389424.1 218556510 7126538 4229025..4230104 1 NC_011741.1 FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site; putative fructose-like permease EIIC subunit 2 4230104 frwC 7126538 frwC Escherichia coli IAI1 putative fructose-like permease EIIC subunit 2 YP_002389424.1 4229025 D 585034 CDS YP_002389425.1 218556511 7128226 4230119..4230439 1 NC_011741.1 FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; putative PTS system fructose-like transporter subunit EIIB 4230439 frwB 7128226 frwB Escherichia coli IAI1 putative PTS system fructose-like transporter subunit EIIB YP_002389425.1 4230119 D 585034 CDS YP_002389426.1 218556512 7128225 4230490..4232787 1 NC_011741.1 involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; putative formate acetyltransferase 2 4232787 pflD 7128225 pflD Escherichia coli IAI1 putative formate acetyltransferase 2 YP_002389426.1 4230490 D 585034 CDS YP_002389427.1 218556513 7124183 4232753..4233631 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95291446, 14673546, 7773398; Product type e : enzyme; pyruvate formate lyase II activase 4233631 pflC 7124183 pflC Escherichia coli IAI1 pyruvate formate lyase II activase YP_002389427.1 4232753 D 585034 CDS YP_002389428.1 218556514 7124182 4233633..4233974 1 NC_011741.1 FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; putative fructose-like phosphotransferase EIIB subunit 3 4233974 frwD 7124182 frwD Escherichia coli IAI1 putative fructose-like phosphotransferase EIIB subunit 3 YP_002389428.1 4233633 D 585034 CDS YP_002389429.1 218556515 7128227 complement(4233961..4234812) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4234812 yijO 7128227 yijO Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002389429.1 4233961 R 585034 CDS YP_002389430.1 218556516 7125355 complement(4234961..4236694) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10456927; Product type pm : putative membrane component; hypothetical protein 4236694 yijP 7125355 yijP Escherichia coli IAI1 hypothetical protein YP_002389430.1 4234961 R 585034 CDS YP_002389431.1 218556517 7125356 complement(4236877..4239528) 1 NC_011741.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 4239528 ppc 7125356 ppc Escherichia coli IAI1 phosphoenolpyruvate carboxylase YP_002389431.1 4236877 R 585034 CDS YP_002389432.1 218556518 7126125 complement(4239880..4241031) 1 NC_011741.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase 4241031 argE 7126125 argE Escherichia coli IAI1 acetylornithine deacetylase YP_002389432.1 4239880 R 585034 CDS YP_002389433.1 218556519 7125790 4241185..4242189 1 NC_011741.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 4242189 argC 7125790 argC Escherichia coli IAI1 N-acetyl-gamma-glutamyl-phosphate reductase YP_002389433.1 4241185 D 585034 CDS YP_002389434.1 218556520 7125788 4242200..4242973 1 NC_011741.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 4242973 argB 7125788 argB Escherichia coli IAI1 acetylglutamate kinase YP_002389434.1 4242200 D 585034 CDS YP_002389435.1 218556521 7125787 4243034..4244407 1 NC_011741.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 4244407 argH 7125787 argH Escherichia coli IAI1 argininosuccinate lyase YP_002389435.1 4243034 D 585034 CDS YP_002389436.1 218556522 7125792 4244845..4246119 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 93341455, 94310441; Product type pe : putative enzyme; putative enolase/dehydratase 4246119 rspA 7125792 rspA Escherichia coli IAI1 putative enolase/dehydratase YP_002389436.1 4244845 D 585034 CDS YP_002389437.1 218556523 7128440 4246186..4247469 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4247469 7128440 ECIAI1_4170 Escherichia coli IAI1 putative transporter YP_002389437.1 4246186 D 585034 CDS YP_002389438.1 218556524 7126003 4247721..4248638 1 NC_011741.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 4248638 oxyR 7126003 oxyR Escherichia coli IAI1 DNA-binding transcriptional regulator OxyR YP_002389438.1 4247721 D 585034 CDS YP_002389439.1 218556525 7126002 complement(4248621..4250021) 1 NC_011741.1 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 4250021 sthA 7126002 sthA Escherichia coli IAI1 soluble pyridine nucleotide transhydrogenase YP_002389439.1 4248621 R 585034 CDS YP_002389440.1 218556526 7126186 4250298..4251002 1 NC_011741.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 4251002 fabR 7126186 fabR Escherichia coli IAI1 DNA-binding transcriptional repressor FabR YP_002389440.1 4250298 D 585034 CDS YP_002389441.1 218556527 7127059 4251002..4251361 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4251361 yijD 7127059 yijD Escherichia coli IAI1 hypothetical protein YP_002389441.1 4251002 D 585034 CDS YP_002389442.1 218556528 7125352 complement(4251401..4252501) 1 NC_011741.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 4252501 trmA 7125352 trmA Escherichia coli IAI1 tRNA (uracil-5-)-methyltransferase YP_002389442.1 4251401 R 585034 CDS YP_002389443.1 218556529 7125504 4252870..4254714 1 NC_011741.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 4254714 btuB 7125504 btuB Escherichia coli IAI1 vitamin B12/cobalamin outer membrane transporter YP_002389443.1 4252870 D 585034 CDS YP_002389444.1 218556530 7124423 4254659..4255516 1 NC_011741.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 4255516 murI 7124423 murI Escherichia coli IAI1 glutamate racemase YP_002389444.1 4254659 D 585034 CDS YP_002389445.1 218556531 7125486 4261202..4262230 1 NC_011741.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 4262230 murB 7125486 murB Escherichia coli IAI1 UDP-N-acetylenolpyruvoylglucosamine reductase YP_002389445.1 4261202 D 585034 CDS YP_002389446.1 218556532 7124493 4262227..4263192 1 NC_011741.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 4263192 birA 7124493 birA Escherichia coli IAI1 biotin--protein ligase YP_002389446.1 4262227 D 585034 CDS YP_002389447.1 218556533 7124414 complement(4263221..4264171) 1 NC_011741.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 4264171 coaA 7124414 coaA Escherichia coli IAI1 pantothenate kinase YP_002389447.1 4263221 R 585034 CDS YP_002389448.1 218556534 7128022 4265089..4266273 1 NC_011741.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4266273 tufB 7128022 tufB Escherichia coli IAI1 elongation factor Tu YP_002389448.1 4265089 D 585034 CDS YP_002389449.1 218556535 7127517 4266503..4266886 1 NC_011741.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 4266886 secE 7127517 secE Escherichia coli IAI1 preprotein translocase subunit SecE YP_002389449.1 4266503 D 585034 CDS YP_002389450.1 218556536 7124694 4266888..4267433 1 NC_011741.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 4267433 nusG 7124694 nusG Escherichia coli IAI1 transcription antitermination protein NusG YP_002389450.1 4266888 D 585034 CDS YP_002389451.1 218556537 7125975 4267592..4268020 1 NC_011741.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 4268020 rplK 7125975 rplK Escherichia coli IAI1 50S ribosomal protein L11 YP_002389451.1 4267592 D 585034 CDS YP_002389452.1 218556538 7128372 4268024..4268728 1 NC_011741.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 4268728 rplA 7128372 rplA Escherichia coli IAI1 50S ribosomal protein L1 YP_002389452.1 4268024 D 585034 CDS YP_002389453.1 218556539 7128618 4269141..4269638 1 NC_011741.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 4269638 rplJ 7128618 rplJ Escherichia coli IAI1 50S ribosomal protein L10 YP_002389453.1 4269141 D 585034 CDS YP_002389454.1 218556540 7128371 4269705..4270070 1 NC_011741.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 4270070 rplL 7128371 rplL Escherichia coli IAI1 50S ribosomal protein L7/L12 YP_002389454.1 4269705 D 585034 CDS YP_002389455.1 218556541 7128373 4270390..4274418 1 NC_011741.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 4274418 rpoB 7128373 rpoB Escherichia coli IAI1 DNA-directed RNA polymerase subunit beta YP_002389455.1 4270390 D 585034 CDS YP_002389456.1 218556542 7128397 4274495..4278718 1 NC_011741.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 4278718 rpoC 7128397 rpoC Escherichia coli IAI1 DNA-directed RNA polymerase subunit beta' YP_002389456.1 4274495 D 585034 CDS YP_002389457.1 218556543 7128398 4278931..4279470 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264341, 92021792, 2160943; Product type f : factor; heat shock protein 4279470 htrC 7128398 htrC Escherichia coli IAI1 heat shock protein YP_002389457.1 4278931 D 585034 CDS YP_002389458.1 218556544 7127978 complement(4279880..4281013) 1 NC_011741.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH 4281013 thiH 7127978 thiH Escherichia coli IAI1 thiamine biosynthesis protein ThiH YP_002389458.1 4279880 R 585034 CDS YP_002389459.1 218556545 7126245 complement(4281010..4281780) 1 NC_011741.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 4281780 thiG 7126245 thiG Escherichia coli IAI1 thiazole synthase YP_002389459.1 4281010 R 585034 CDS YP_002389460.1 218556546 7126244 complement(4281782..4281982) 1 NC_011741.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS 4281982 thiS 7126244 thiS Escherichia coli IAI1 sulfur carrier protein ThiS YP_002389460.1 4281782 R 585034 CDS YP_002389461.1 218556547 7126251 complement(4281966..4282721) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8432721, 94089392, 98298179, 10082377, 9632726; Product type e : enzyme; thiamin (thiazole moiety) biosynthesis protein 4282721 thiF 7126251 thiF Escherichia coli IAI1 thiamin (thiazole moiety) biosynthesis protein YP_002389461.1 4281966 R 585034 CDS YP_002389462.1 218556548 7126243 complement(4282714..4283349) 1 NC_011741.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase 4283349 thiE 7126243 thiE Escherichia coli IAI1 thiamine-phosphate pyrophosphorylase YP_002389462.1 4282714 R 585034 CDS YP_002389463.1 218556549 7126242 complement(4283349..4285244) 1 NC_011741.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 4285244 thiC 7126242 thiC Escherichia coli IAI1 thiamine biosynthesis protein ThiC YP_002389463.1 4283349 R 585034 CDS YP_002389464.1 218556550 7125505 complement(4285477..4285953) 1 NC_011741.1 binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor 4285953 rsd 7125505 rsd Escherichia coli IAI1 anti-RNA polymerase sigma 70 factor YP_002389464.1 4285477 R 585034 CDS YP_002389465.1 218556551 7128431 4286048..4286821 1 NC_011741.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 4286821 nudC 7128431 nudC Escherichia coli IAI1 NADH pyrophosphatase YP_002389465.1 4286048 D 585034 CDS YP_002389466.1 218556552 7125952 4286861..4287925 1 NC_011741.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 4287925 hemE 7125952 hemE Escherichia coli IAI1 uroporphyrinogen decarboxylase YP_002389466.1 4286861 D 585034 CDS YP_002389467.1 218556553 7128509 4287935..4288606 1 NC_011741.1 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 4288606 nfi 7128509 nfi Escherichia coli IAI1 endonuclease V YP_002389467.1 4287935 D 585034 CDS YP_002389468.1 218556554 7127867 4288649..4289239 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4289239 yjaG 7127867 yjaG Escherichia coli IAI1 hypothetical protein YP_002389468.1 4288649 D 585034 CDS YP_002389469.1 218556555 7125358 4289426..4289698 1 NC_011741.1 histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 4289698 hupA 7125358 hupA Escherichia coli IAI1 transcriptional regulator HU subunit alpha YP_002389469.1 4289426 D 585034 CDS YP_002389470.1 218556556 7125324 4289711..4290406 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4290406 yjaH 7125324 yjaH Escherichia coli IAI1 hypothetical protein YP_002389470.1 4289711 D 585034 CDS YP_002389471.1 218556557 7125359 complement(4290408..4290833) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98362023, 9694902; Product type pf : putative factor; zinc resistance protein 4290833 zraP 7125359 zraP Escherichia coli IAI1 zinc resistance protein YP_002389471.1 4290408 R 585034 CDS YP_002389472.1 218556558 7128131 4291071..4292447 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21140164, 89327164, 92255260, 11243806, 2666400; Product type r : regulator; sensor protein ZraS 4292447 zraS 7128131 zraS Escherichia coli IAI1 sensor protein ZraS YP_002389472.1 4291071 D 585034 CDS YP_002389473.1 218556559 7128133 4292444..4293769 1 NC_011741.1 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 4293769 zraR 7128133 zraR Escherichia coli IAI1 transcriptional regulatory protein ZraR YP_002389473.1 4292444 D 585034 CDS YP_002389474.1 218556560 7128132 complement(4293766..4295055) 1 NC_011741.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 4295055 purD 7128132 purD Escherichia coli IAI1 phosphoribosylamine--glycine ligase YP_002389474.1 4293766 R 585034 CDS YP_002389475.1 218556561 7126547 complement(4295067..4296656) 1 NC_011741.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 4296656 purH 7126547 purH Escherichia coli IAI1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_002389475.1 4295067 R 585034 CDS YP_002389476.1 218556562 7125487 complement(4302400..4302843) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; hypothetical protein 4302843 yjaB 7125487 yjaB Escherichia coli IAI1 hypothetical protein YP_002389476.1 4302400 R 585034 CDS YP_002389477.1 218556563 7125357 4303000..4303929 1 NC_011741.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 4303929 metA 7125357 metA Escherichia coli IAI1 homoserine O-succinyltransferase YP_002389477.1 4303000 D 585034 CDS YP_002389478.1 218556564 7124242 4304198..4305799 1 NC_011741.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 4305799 aceB 7124242 aceB Escherichia coli IAI1 malate synthase YP_002389478.1 4304198 D 585034 CDS YP_002389479.1 218556565 7125695 4305829..4307133 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91295197, 92112731, 92353108, 2836370, 3049537, 3060852, 3276689, 3290857, 3291954, 7826335; Product type e : enzyme; isocitrate lyase 4307133 aceA 7125695 aceA Escherichia coli IAI1 isocitrate lyase YP_002389479.1 4305829 D 585034 CDS YP_002389480.1 218556566 7125694 4307202..4307438 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 4307438 7125694 ECIAI1_4236 Escherichia coli IAI1 hypothetical protein YP_002389480.1 4307202 D 585034 CDS YP_002389481.1 218556567 7125667 4307414..4309150 1 NC_011741.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol; bifunctional isocitrate dehydrogenase kinase/phosphatase protein 4309150 aceK 7125667 aceK Escherichia coli IAI1 bifunctional isocitrate dehydrogenase kinase/phosphatase protein YP_002389481.1 4307414 D 585034 CDS YP_002389482.1 218556568 7125815 complement(4311010..4311834) 1 NC_011741.1 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; transcriptional repressor IclR 4311834 iclR 7125815 iclR Escherichia coli IAI1 transcriptional repressor IclR YP_002389482.1 4311010 R 585034 CDS YP_002389483.1 218556569 7126044 4312034..4315717 1 NC_011741.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 4315717 metH 7126044 metH Escherichia coli IAI1 B12-dependent methionine synthase YP_002389483.1 4312034 D 585034 CDS YP_002389484.1 218556570 7124248 4315937..4317568 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4317568 yjbB 7124248 yjbB Escherichia coli IAI1 putative transporter YP_002389484.1 4315937 D 585034 CDS YP_002389485.1 218556571 7125361 complement(4317659..4318348) 1 NC_011741.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E 4318348 pepE 7125361 pepE Escherichia coli IAI1 peptidase E YP_002389485.1 4317659 R 585034 CDS YP_002389486.1 218556572 7124172 4318560..4319432 1 NC_011741.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 4319432 yjbC 7124172 yjbC Escherichia coli IAI1 23S rRNA pseudouridine synthase F YP_002389486.1 4318560 D 585034 CDS YP_002389487.1 218556573 7125362 complement(4319433..4319705) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4319705 yjbD 7125362 yjbD Escherichia coli IAI1 hypothetical protein YP_002389487.1 4319433 R 585034 CDS YP_002389488.1 218556574 7125363 4320235..4321362 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4321362 7125363 ECIAI1_4246 Escherichia coli IAI1 hypothetical protein YP_002389488.1 4320235 D 585034 CDS YP_002389489.1 218556575 7125668 4321359..4322159 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4322159 7125668 ECIAI1_4247 Escherichia coli IAI1 hypothetical protein YP_002389489.1 4321359 D 585034 CDS YP_002389490.1 218556576 7125669 complement(4322195..4323127) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative zeta toxin; poison-antidote element 4323127 7125669 ECIAI1_4248 Escherichia coli IAI1 putative zeta toxin; poison-antidote element YP_002389490.1 4322195 R 585034 CDS YP_002389491.1 218556577 7125670 complement(4323266..4324615) 1 NC_011741.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase III 4324615 lysC 7125670 lysC Escherichia coli IAI1 aspartate kinase III YP_002389491.1 4323266 R 585034 CDS YP_002389492.1 218556578 7125506 4325140..4326789 1 NC_011741.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 4326789 pgi 7125506 pgi Escherichia coli IAI1 glucose-6-phosphate isomerase YP_002389492.1 4325140 D 585034 CDS YP_002389493.1 218556579 7124185 complement(4327125..4327373) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4327373 7124185 ECIAI1_4251 Escherichia coli IAI1 hypothetical protein YP_002389493.1 4327125 R 585034 CDS YP_002389494.1 218556580 7127531 4327500..4328138 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 4328138 yjbF 7127531 yjbF Escherichia coli IAI1 hypothetical protein YP_002389494.1 4327500 D 585034 CDS YP_002389495.1 218556581 7125364 4328135..4328872 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4328872 yjbG 7125364 yjbG Escherichia coli IAI1 hypothetical protein YP_002389495.1 4328135 D 585034 CDS YP_002389496.1 218556582 7125365 4328872..4330968 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative porin 4330968 yjbH 7125365 yjbH Escherichia coli IAI1 putative porin YP_002389496.1 4328872 D 585034 CDS YP_002389497.1 218556583 7125366 4330972..4331133 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 4331133 7125366 ECIAI1_4255 Escherichia coli IAI1 hypothetical protein YP_002389497.1 4330972 D 585034 CDS YP_002389498.1 218556584 7125430 complement(4331015..4331293) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4331293 7125430 ECIAI1_4256 Escherichia coli IAI1 hypothetical protein YP_002389498.1 4331015 R 585034 CDS YP_002389499.1 218556585 7125431 4331353..4331511 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 4331511 7125431 ECIAI1_4257 Escherichia coli IAI1 hypothetical protein YP_002389499.1 4331353 D 585034 CDS YP_002389500.1 218556586 7125432 4331508..4331918 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10986267; Product type pm : putative membrane component; phosphate-starvation-inducible protein PsiE 4331918 yjbA 7125432 yjbA Escherichia coli IAI1 phosphate-starvation-inducible protein PsiE YP_002389500.1 4331508 D 585034 CDS YP_002389501.1 218556587 7125360 complement(4331962..4333437) 1 NC_011741.1 xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter; D-xylose transporter XylE 4333437 xylE 7125360 xylE Escherichia coli IAI1 D-xylose transporter XylE YP_002389501.1 4331962 R 585034 CDS YP_002389502.1 218556588 7126479 complement(4333809..4334699) 1 NC_011741.1 with MalKFE is involved in the transport of maltose into the cell; maltose transporter permease 4334699 malG 7126479 malG Escherichia coli IAI1 maltose transporter permease YP_002389502.1 4333809 R 585034 CDS YP_002389503.1 218556589 7127656 complement(4334714..4336258) 1 NC_011741.1 with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein 4336258 malF 7127656 malF Escherichia coli IAI1 maltose transporter membrane protein YP_002389503.1 4334714 R 585034 CDS YP_002389504.1 218556590 7127655 complement(4336412..4337602) 1 NC_011741.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter periplasmic protein 4337602 malE 7127655 malE Escherichia coli IAI1 maltose ABC transporter periplasmic protein YP_002389504.1 4336412 R 585034 CDS YP_002389505.1 218556591 7127654 4337967..4339082 1 NC_011741.1 with malEFG is involved in import of maltose/maltodextrin; maltose/maltodextrin transporter ATP-binding protein 4339082 malK 7127654 malK Escherichia coli IAI1 maltose/maltodextrin transporter ATP-binding protein YP_002389505.1 4337967 D 585034 CDS YP_002389506.1 218556592 7127658 4339154..4340494 1 NC_011741.1 porin involved in the transport of maltose and maltodextrins; maltoporin 4340494 lamB 7127658 lamB Escherichia coli IAI1 maltoporin YP_002389506.1 4339154 D 585034 CDS YP_002389507.1 218556593 7126396 4340646..4341566 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87141162, 2434655, 6086106; Product type pt : putative transporter; maltose regulon periplasmic protein 4341566 malM 7126396 malM Escherichia coli IAI1 maltose regulon periplasmic protein YP_002389507.1 4340646 D 585034 CDS YP_002389508.1 218556594 7127659 4341792..4341986 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4341986 7127659 ECIAI1_4267 Escherichia coli IAI1 hypothetical protein YP_002389508.1 4341792 D 585034 CDS YP_002389509.1 218556595 7125433 4342044..4343372 1 NC_011741.1 in E. coli, some yjbl mutations have been reported as suppressors of dnaG mutations; hypothetical protein 4343372 yjbI 7125433 yjbI Escherichia coli IAI1 hypothetical protein YP_002389509.1 4342044 D 585034 CDS YP_002389510.1 218556596 7125367 4343595..4344092 1 NC_011741.1 catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 4344092 ubiC 7125367 ubiC Escherichia coli IAI1 chorismate pyruvate lyase YP_002389510.1 4343595 D 585034 CDS YP_002389511.1 218556597 7125511 4344105..4344977 1 NC_011741.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 4344977 ubiA 7125511 ubiA Escherichia coli IAI1 4-hydroxybenzoate octaprenyltransferase YP_002389511.1 4344105 D 585034 CDS YP_002389512.1 218556598 7124380 complement(4345132..4347555) 1 NC_011741.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 4347555 plsB 7124380 plsB Escherichia coli IAI1 glycerol-3-phosphate acyltransferase YP_002389512.1 4345132 R 585034 CDS YP_002389513.1 218556599 7126099 4347726..4348094 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10220339, 6257698, 86278195, 88111690, 2984194, 6309817, 8071224; Product type e : enzyme; diacylglycerol kinase 4348094 dgkA 7126099 dgkA Escherichia coli IAI1 diacylglycerol kinase YP_002389513.1 4347726 D 585034 CDS YP_002389514.1 218556600 7124571 4348204..4348812 1 NC_011741.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 4348812 lexA 7124571 lexA Escherichia coli IAI1 LexA repressor YP_002389514.1 4348204 D 585034 CDS YP_002389515.1 218556601 7126414 4348831..4350210 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87165788; Product type cp : cell process; DNA-damage-inducible SOS response protein 4350210 dinF 7126414 dinF Escherichia coli IAI1 DNA-damage-inducible SOS response protein YP_002389515.1 4348831 D 585034 CDS YP_002389516.1 218556602 7124588 4350326..4350535 1 NC_011741.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; putative stress-response protein 4350535 yjbJ 7124588 yjbJ Escherichia coli IAI1 putative stress-response protein YP_002389516.1 4350326 D 585034 CDS YP_002389517.1 218556603 7125368 complement(4350577..4351092) 1 NC_011741.1 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor 4351092 zur 7125368 zur Escherichia coli IAI1 zinc uptake transcriptional repressor YP_002389517.1 4350577 R 585034 CDS YP_002389518.1 218556604 7128135 4351410..4351664 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4351664 yjbL 7128135 yjbL Escherichia coli IAI1 hypothetical protein YP_002389518.1 4351410 D 585034 CDS YP_002389519.1 218556605 7125369 4351688..4352395 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4352395 yjbM 7125369 yjbM Escherichia coli IAI1 hypothetical protein YP_002389519.1 4351688 D 585034 CDS YP_002389520.1 218556606 7125370 4352758..4353795 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566; Product type e : enzyme; tRNA-dihydrouridine synthase A 4353795 yjbN 7125370 yjbN Escherichia coli IAI1 tRNA-dihydrouridine synthase A YP_002389520.1 4352758 D 585034 CDS YP_002389521.1 218556607 7125371 4353719..4354171 1 NC_011741.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 4354171 pspG 7125371 pspG Escherichia coli IAI1 phage shock protein G YP_002389521.1 4353719 D 585034 CDS YP_002389522.1 218556608 7125372 complement(4354337..4355320) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94089392, 7602590; Product type e : enzyme; quinone oxidoreductase 4355320 qor 7125372 qor Escherichia coli IAI1 quinone oxidoreductase YP_002389522.1 4354337 R 585034 CDS YP_002389523.1 218556609 7126579 4355403..4356818 1 NC_011741.1 unwinds double stranded DNA; replicative DNA helicase 4356818 dnaB 7126579 dnaB Escherichia coli IAI1 replicative DNA helicase YP_002389523.1 4355403 D 585034 CDS YP_002389524.1 218556610 7124605 4356871..4357950 1 NC_011741.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 4357950 alr 7124605 alr Escherichia coli IAI1 alanine racemase YP_002389524.1 4356871 D 585034 CDS YP_002389525.1 218556611 7124781 4358203..4359396 1 NC_011741.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 4359396 tyrB 7124781 tyrB Escherichia coli IAI1 aromatic amino acid aminotransferase YP_002389525.1 4358203 D 585034 CDS YP_002389526.1 218556612 7127526 complement(4359618..4360160) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4360160 7127526 ECIAI1_4286 Escherichia coli IAI1 hypothetical protein YP_002389526.1 4359618 R 585034 CDS YP_002389527.1 218556613 7125434 4360523..4361236 1 NC_011741.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 4361236 aphA 7125434 aphA Escherichia coli IAI1 acid phosphatase/phosphotransferase YP_002389527.1 4360523 D 585034 CDS YP_002389528.1 218556614 7125769 4361347..4361763 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11972052; hypothetical protein 4361763 yjbQ 7125769 yjbQ Escherichia coli IAI1 hypothetical protein YP_002389528.1 4361347 D 585034 CDS YP_002389529.1 218556615 7125373 4361767..4362123 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4362123 yjbR 7125373 yjbR Escherichia coli IAI1 hypothetical protein YP_002389529.1 4361767 D 585034 CDS YP_002389530.1 218556616 7125374 complement(4362158..4364980) 1 NC_011741.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 4364980 uvrA 7125374 uvrA Escherichia coli IAI1 excinuclease ABC subunit A YP_002389530.1 4362158 R 585034 CDS YP_002389531.1 218556617 7125555 4365234..4365770 1 NC_011741.1 binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 4365770 ssb 7125555 ssb Escherichia coli IAI1 single-stranded DNA-binding protein YP_002389531.1 4365234 D 585034 CDS YP_002389532.1 218556618 7127979 complement(4365869..4366150) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4366150 yjcB 7127979 yjcB Escherichia coli IAI1 hypothetical protein YP_002389532.1 4365869 R 585034 CDS YP_002389533.1 218556619 7125375 4366580..4368166 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative signal transduction protein 4368166 yjcC 7125375 yjcC Escherichia coli IAI1 putative signal transduction protein YP_002389533.1 4366580 D 585034 CDS YP_002389534.1 218556620 7125376 complement(4368169..4368492) 1 NC_011741.1 regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS 4368492 soxS 7125376 soxS Escherichia coli IAI1 DNA-binding transcriptional regulator SoxS YP_002389534.1 4368169 R 585034 CDS YP_002389535.1 218556621 7127950 4368578..4369042 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91210176, 91360349, 94139656, 9564045, 10207625, 12670967, 1653416, 1708380, 7673113, 8065907, 8306957, 8631739, 8969171, 9019397, 9092651, 9204707; Product type r : regulator; DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing 4369042 soxR 7127950 soxR Escherichia coli IAI1 DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing YP_002389535.1 4368578 D 585034 CDS YP_002389536.1 218556622 7124666 4369588..4370937 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease 4370937 yjcD 7124666 yjcD Escherichia coli IAI1 putative permease YP_002389536.1 4369588 D 585034 CDS YP_002389537.1 218556623 7125377 4371088..4372737 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 21557160, 11479290; Product type pt : putative transporter; putative cation/proton antiporter 4372737 yjcE 7125377 yjcE Escherichia coli IAI1 putative cation/proton antiporter YP_002389537.1 4371088 D 585034 CDS YP_002389538.1 218556624 7125378 complement(4372891..4374183) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4374183 yjcF 7125378 yjcF Escherichia coli IAI1 hypothetical protein YP_002389538.1 4372891 R 585034 CDS YP_002389539.1 218556625 7125379 complement(4374361..4376010) 1 NC_011741.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease 4376010 actP 7125379 actP Escherichia coli IAI1 acetate permease YP_002389539.1 4374361 R 585034 CDS YP_002389540.1 218556626 7125713 complement(4376007..4376321) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14563880; Product type pm : putative membrane component; hypothetical protein 4376321 yjcH 7125713 yjcH Escherichia coli IAI1 hypothetical protein YP_002389540.1 4376007 R 585034 CDS YP_002389541.1 218556627 7125380 complement(4376521..4378479) 1 NC_011741.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 4378479 acs 7125380 acs Escherichia coli IAI1 acetyl-CoA synthetase YP_002389541.1 4376521 R 585034 CDS YP_002389542.1 218556628 7125712 4378872..4380308 1 NC_011741.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 4380308 nrfA 7125712 nrfA Escherichia coli IAI1 cytochrome c552 YP_002389542.1 4378872 D 585034 CDS YP_002389543.1 218556629 7125942 4380353..4380919 1 NC_011741.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 4380919 nrfB 7125942 nrfB Escherichia coli IAI1 cytochrome c nitrite reductase pentaheme subunit YP_002389543.1 4380353 D 585034 CDS YP_002389544.1 218556630 7125943 4380916..4381587 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94335626, 8057835; Product type c : carrier; formate-dependent nitrite reductase, 4Fe4S subunit 4381587 nrfC 7125943 nrfC Escherichia coli IAI1 formate-dependent nitrite reductase, 4Fe4S subunit YP_002389544.1 4380916 D 585034 CDS YP_002389545.1 218556631 7125944 4381584..4382540 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 8057835; Product type e : enzyme; formate-dependent nitrite reductase, membrane subunit 4382540 nrfD 7125944 nrfD Escherichia coli IAI1 formate-dependent nitrite reductase, membrane subunit YP_002389545.1 4381584 D 585034 CDS YP_002389546.1 218556632 7125945 4382620..4384278 1 NC_011741.1 with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 4384278 nrfE 7125945 nrfE Escherichia coli IAI1 heme lyase subunit NrfE YP_002389546.1 4382620 D 585034 CDS YP_002389547.1 218556633 7125946 4384271..4384654 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 9593308, 8057835, 8842153; Product type f : factor; formate-dependent nitrite reductase complex subunit NrfF 4384654 nrfF 7125946 nrfF Escherichia coli IAI1 formate-dependent nitrite reductase complex subunit NrfF YP_002389547.1 4384271 D 585034 CDS YP_002389548.1 218556634 7125947 4384651..4385247 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 9593308, 8057835, 8842153; Product type f : factor; formate-dependent nitrite reductase complex subunit NrfG 4385247 nrfG 7125947 nrfG Escherichia coli IAI1 formate-dependent nitrite reductase complex subunit NrfG YP_002389548.1 4384651 D 585034 CDS YP_002389549.1 218556635 7125948 4385589..4386902 1 NC_011741.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 4386902 gltP 7125948 gltP Escherichia coli IAI1 glutamate/aspartate:proton symporter YP_002389549.1 4385589 D 585034 CDS YP_002389550.1 218556636 7128353 complement(4386980..4387669) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4387669 yjcO 7128353 yjcO Escherichia coli IAI1 hypothetical protein YP_002389550.1 4386980 R 585034 CDS YP_002389551.1 218556637 7125381 complement(4387763..4389910) 1 NC_011741.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-H, selenopolypeptide subunit 4389910 fdhF 7125381 fdhF Escherichia coli IAI1 formate dehydrogenase-H, selenopolypeptide subunit YP_002389551.1 4387763 R 585034 CDS YP_002389552.1 218556638 7127074 complement(4390108..4391574) 1 NC_011741.1 part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; putative outer membrane efflux protein MdtP 4391574 yjcP 7127074 yjcP Escherichia coli IAI1 putative outer membrane efflux protein MdtP YP_002389552.1 4390108 R 585034 CDS YP_002389553.1 218556639 7125382 complement(4391571..4393622) 1 NC_011741.1 possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO 4393622 yjcQ 7125382 yjcQ Escherichia coli IAI1 multidrug efflux system protein MdtO YP_002389553.1 4391571 R 585034 CDS YP_002389554.1 218556640 7125383 complement(4393622..4394653) 1 NC_011741.1 with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN 4394653 yjcR 7125383 yjcR Escherichia coli IAI1 multidrug resistance protein MdtN YP_002389554.1 4393622 R 585034 CDS YP_002389555.1 218556641 7125384 complement(4394672..4394995) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4394995 7125384 ECIAI1_4318 Escherichia coli IAI1 hypothetical protein YP_002389555.1 4394672 R 585034 CDS YP_002389556.1 218556642 7125435 complement(4395156..4397141) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1587481; Product type pe : putative enzyme; putative alkyl sulfatase 4397141 yjcS 7125435 yjcS Escherichia coli IAI1 putative alkyl sulfatase YP_002389556.1 4395156 R 585034 CDS YP_002389557.1 218556643 7125385 4397394..4397711 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ribose-5-phosphate isomerase B (rpiB-like) 4397711 7125385 ECIAI1_4320 Escherichia coli IAI1 putative ribose-5-phosphate isomerase B (rpiB-like) YP_002389557.1 4397394 D 585034 CDS YP_002389558.1 218556644 7125436 4397780..4398109 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4398109 yjdP 7125436 yjdP Escherichia coli IAI1 hypothetical protein YP_002389558.1 4397780 D 585034 CDS YP_002389559.1 218556645 7125395 complement(4398256..4399014) 1 NC_011741.1 required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein 4399014 phnP 7125395 phnP Escherichia coli IAI1 carbon-phosphorus lyase complex accessory protein YP_002389559.1 4398256 R 585034 CDS YP_002389560.1 218556646 7124213 complement(4399016..4399450) 1 NC_011741.1 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase 4399450 phnO 7124213 phnO Escherichia coli IAI1 aminoalkylphosphonic acid N-acetyltransferase YP_002389560.1 4399016 R 585034 CDS YP_002389561.1 218556647 7124212 complement(4399437..4399994) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12700258, 91100346, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; ribose 1,5-bisphosphokinase 4399994 phnN 7124212 phnN Escherichia coli IAI1 ribose 1,5-bisphosphokinase YP_002389561.1 4399437 R 585034 CDS YP_002389562.1 218556648 7124211 complement(4399994..4401130) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100346, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4401130 phnM 7124211 phnM Escherichia coli IAI1 carbon-phosphorus lyase complex subunit YP_002389562.1 4399994 R 585034 CDS YP_002389563.1 218556649 7124210 complement(4401127..4401807) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4401807 phnL 7124210 phnL Escherichia coli IAI1 carbon-phosphorus lyase complex subunit YP_002389563.1 4401127 R 585034 CDS YP_002389564.1 218556650 7124209 complement(4401918..4402676) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; phosphonate C-P lyase system protein PhnK 4402676 phnK 7124209 phnK Escherichia coli IAI1 phosphonate C-P lyase system protein PhnK YP_002389564.1 4401918 R 585034 CDS YP_002389565.1 218556651 7124208 complement(4402673..4403518) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4403518 phnJ 7124208 phnJ Escherichia coli IAI1 carbon-phosphorus lyase complex subunit YP_002389565.1 4402673 R 585034 CDS YP_002389566.1 218556652 7124207 complement(4403511..4404575) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4404575 phnI 7124207 phnI Escherichia coli IAI1 carbon-phosphorus lyase complex subunit YP_002389566.1 4403511 R 585034 CDS YP_002389567.1 218556653 7124206 complement(4404575..4405159) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4405159 phnH 7124206 phnH Escherichia coli IAI1 carbon-phosphorus lyase complex subunit YP_002389567.1 4404575 R 585034 CDS YP_002389568.1 218556654 7124205 complement(4405156..4405608) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4405608 phnG 7124205 phnG Escherichia coli IAI1 carbon-phosphorus lyase complex subunit YP_002389568.1 4405156 R 585034 CDS YP_002389569.1 218556655 7124204 complement(4405609..4406334) 1 NC_011741.1 may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF 4406334 phnF 7124204 phnF Escherichia coli IAI1 phosphonate metabolism transcriptional regulator PhnF YP_002389569.1 4405609 R 585034 CDS YP_002389570.1 218556656 7124203 complement(4406355..4407134) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; phosphonates transport system, permease 4407134 phnE 7124203 phnE Escherichia coli IAI1 phosphonates transport system, permease YP_002389570.1 4406355 R 585034 CDS YP_002389571.1 218556657 7124202 complement(4407196..4408212) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type t : transporter; phosphonate/organophosphate ester ABC transporter periplasmic-binding protein 4408212 phnD 7124202 phnD Escherichia coli IAI1 phosphonate/organophosphate ester ABC transporter periplasmic-binding protein YP_002389571.1 4407196 R 585034 CDS YP_002389572.1 218556658 7124201 complement(4408237..4409025) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type t : transporter; phosphonate/organophosphate ester transporter subunit 4409025 phnC 7124201 phnC Escherichia coli IAI1 phosphonate/organophosphate ester transporter subunit YP_002389572.1 4408237 R 585034 CDS YP_002389573.1 218556659 7124200 complement(4409158..4409601) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 93328121, 9650256, 2155230; hypothetical protein 4409601 phnB 7124200 phnB Escherichia coli IAI1 hypothetical protein YP_002389573.1 4409158 R 585034 CDS YP_002389574.1 218556660 7124199 complement(4409761..4410096) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 93328121, 9650256, 2155230; hypothetical protein 4410096 phnA 7124199 phnA Escherichia coli IAI1 hypothetical protein YP_002389574.1 4409761 R 585034 CDS YP_002389575.1 218556661 7124198 4410498..4412726 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4412726 yjdA 7124198 yjdA Escherichia coli IAI1 hypothetical protein YP_002389575.1 4410498 D 585034 CDS YP_002389576.1 218556662 7125387 4412723..4413601 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4413601 yjcZ 7125387 yjcZ Escherichia coli IAI1 hypothetical protein YP_002389576.1 4412723 D 585034 CDS YP_002389577.1 218556663 7125386 4413865..4415367 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10049386, 12525168, 92165733, 93132799, 9871325, 99376621, 8421314; Product type t : transporter; proline/glycine betaine transporter 4415367 proP 7125386 proP Escherichia coli IAI1 proline/glycine betaine transporter YP_002389577.1 4413865 D 585034 CDS YP_002389578.1 218556664 7126159 complement(4415544..4416635) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94110256, 8282725; Product type r : regulator; sensor protein BasS/PmrB 4416635 basS 7126159 basS Escherichia coli IAI1 sensor protein BasS/PmrB YP_002389578.1 4415544 R 585034 CDS YP_002389579.1 218556665 7124382 complement(4416645..4417313) 1 NC_011741.1 response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR 4417313 basR 7124382 basR Escherichia coli IAI1 DNA-binding transcriptional regulator BasR YP_002389579.1 4416645 R 585034 CDS YP_002389580.1 218556666 7124381 complement(4417310..4418953) 1 NC_011741.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; putative cell division protein 4418953 eptA 7124381 eptA Escherichia coli IAI1 putative cell division protein YP_002389580.1 4417310 R 585034 CDS YP_002389581.1 218556667 7125086 complement(4419057..4420394) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12867448; Product type t : transporter; arginine:agmatin antiporter 4420394 adiC 7125086 adiC Escherichia coli IAI1 arginine:agmatin antiporter YP_002389581.1 4419057 R 585034 CDS YP_002389582.1 218556668 7125720 complement(4420531..4421292) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : c; Product type r : regulator; DNA-binding transcriptional activator 4421292 adiY 7125720 adiY Escherichia coli IAI1 DNA-binding transcriptional activator YP_002389582.1 4420531 R 585034 CDS YP_002389583.1 218556669 7125721 complement(4421617..4423887) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93186686, 2830169, 4204273, 8383109; Product type e : enzyme; biodegradative arginine decarboxylase 4423887 adiA 7125721 adiA Escherichia coli IAI1 biodegradative arginine decarboxylase YP_002389583.1 4421617 R 585034 CDS YP_002389584.1 218556670 7125719 complement(4424083..4424991) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90060832, 9108148, 1445207, 2684786, 2830169; Product type r : regulator; DNA-binding transcriptional regulator MelR 4424991 melR 7125719 melR Escherichia coli IAI1 DNA-binding transcriptional regulator MelR YP_002389584.1 4424083 R 585034 CDS YP_002389585.1 218556671 7124234 4425274..4426629 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87174747, 88162811, 90248411, 2831880, 3031590, 6329200; Product type e : enzyme; alpha-galactosidase 4426629 melA 7124234 melA Escherichia coli IAI1 alpha-galactosidase YP_002389585.1 4425274 D 585034 CDS YP_002389586.1 218556672 7124232 4426744..4428153 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14757226, 90241878, 92297631, 93155159, 1730719, 1872836, 6323466, 8672452; Product type t : transporter; melibiose:sodium symporter 4428153 melB 7124232 melB Escherichia coli IAI1 melibiose:sodium symporter YP_002389586.1 4426744 D 585034 CDS YP_002389587.1 218556673 7124233 complement(4428292..4428921) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4428921 yjdF 7124233 yjdF Escherichia coli IAI1 hypothetical protein YP_002389587.1 4428292 R 585034 CDS YP_002389588.1 218556674 7125389 complement(4429044..4430690) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86142617, 88193096, 89255123, 2656658; Product type e : enzyme; anaerobic class I fumarate hydratase 4430690 fumB 7125389 fumB Escherichia coli IAI1 anaerobic class I fumarate hydratase YP_002389588.1 4429044 R 585034 CDS YP_002389589.1 218556675 7128253 complement(4430768..4432108) 1 NC_011741.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter 4432108 dcuB 7128253 dcuB Escherichia coli IAI1 anaerobic C4-dicarboxylate transporter YP_002389589.1 4430768 R 585034 CDS YP_002389590.1 218556676 7126928 complement(4432679..4433398) 1 NC_011741.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR 4433398 dcuR 7126928 dcuR Escherichia coli IAI1 DNA-binding transcriptional activator DcuR YP_002389590.1 4432679 R 585034 CDS YP_002389591.1 218556677 7124545 complement(4433395..4435026) 1 NC_011741.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS 4435026 dcuS 7124545 dcuS Escherichia coli IAI1 sensory histidine kinase DcuS YP_002389591.1 4433395 R 585034 CDS YP_002389592.1 218556678 7124546 4435207..4435437 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4435437 yjdI 7124546 yjdI Escherichia coli IAI1 hypothetical protein YP_002389592.1 4435207 D 585034 CDS YP_002389593.1 218556679 7125390 4435449..4435721 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyltransferase with acyl-CoA N-acyltransferase domain 4435721 yjdJ 7125390 yjdJ Escherichia coli IAI1 putative acyltransferase with acyl-CoA N-acyltransferase domain YP_002389593.1 4435449 D 585034 CDS YP_002389594.1 218556680 7125391 4435948..4436244 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4436244 yjdK 7125391 yjdK Escherichia coli IAI1 hypothetical protein YP_002389594.1 4435948 D 585034 CDS YP_002389595.1 218556681 7125392 4436272..4436445 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4436445 yjdO 7125392 yjdO Escherichia coli IAI1 hypothetical protein YP_002389595.1 4436272 D 585034 CDS YP_002389596.1 218556682 7125394 complement(4436564..4438081) 1 NC_011741.1 class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 4438081 lysU 7125394 lysU Escherichia coli IAI1 lysyl-tRNA synthetase YP_002389596.1 4436564 R 585034 CDS YP_002389597.1 218556683 7127647 complement(4438318..4439775) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4439775 yjdL 7127647 yjdL Escherichia coli IAI1 putative transporter YP_002389597.1 4438318 R 585034 CDS YP_002389598.1 218556684 7125393 complement(4439834..4441981) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92105022, 92210511, 1370290, 1556085, 4204273; Product type e : enzyme; lysine decarboxylase 1 4441981 cadA 7125393 cadA Escherichia coli IAI1 lysine decarboxylase 1 YP_002389598.1 4439834 R 585034 CDS YP_002389599.1 218556685 7124437 complement(4442061..4443395) 1 NC_011741.1 antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein; lysine/cadaverine antiporter 4443395 cadB 7124437 cadB Escherichia coli IAI1 lysine/cadaverine antiporter YP_002389599.1 4442061 R 585034 CDS YP_002389600.1 218556686 7124438 complement(4443761..4445299) 1 NC_011741.1 regulates the cadBA operon; DNA-binding transcriptional activator CadC 4445299 cadC 7124438 cadC Escherichia coli IAI1 DNA-binding transcriptional activator CadC YP_002389600.1 4443761 R 585034 CDS YP_002389601.1 218556687 7124439 4445586..4445804 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4445804 7124439 ECIAI1_4367 Escherichia coli IAI1 hypothetical protein YP_002389601.1 4445586 D 585034 CDS YP_002389602.1 218556688 7128032 complement(4446098..4446673) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1370290; Product type pr : putative regulator; putative transcriptional regulator 4446673 yjdC 7128032 yjdC Escherichia coli IAI1 putative transcriptional regulator YP_002389602.1 4446098 R 585034 CDS YP_002389603.1 218556689 7125388 complement(4446710..4448407) 1 NC_011741.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein 4448407 dipZ 7125388 dipZ Escherichia coli IAI1 thiol:disulfide interchange protein YP_002389603.1 4446710 R 585034 CDS YP_002389604.1 218556690 7124592 complement(4448383..4448721) 1 NC_011741.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA 4448721 cutA 7124592 cutA Escherichia coli IAI1 divalent-cation tolerance protein CutA YP_002389604.1 4448383 R 585034 CDS YP_002389605.1 218556691 7126865 complement(4448837..4450138) 1 NC_011741.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 4450138 dcuA 7126865 dcuA Escherichia coli IAI1 anaerobic C4-dicarboxylate transporter YP_002389605.1 4448837 R 585034 CDS YP_002389606.1 218556692 7126927 complement(4450256..4451692) 1 NC_011741.1 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 4451692 aspA 7126927 aspA Escherichia coli IAI1 aspartate ammonia-lyase YP_002389606.1 4450256 R 585034 CDS YP_002389607.1 218556693 7126265 4452029..4452505 1 NC_011741.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA 4452505 fxsA 7126265 fxsA Escherichia coli IAI1 FxsA YP_002389607.1 4452029 D 585034 CDS YP_002389608.1 218556694 7128257 complement(4452521..4453777) 1 NC_011741.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function; inner membrane protein YjeH 4453777 yjeH 7128257 yjeH Escherichia coli IAI1 inner membrane protein YjeH YP_002389608.1 4452521 R 585034 CDS YP_002389609.1 218556695 7125398 4454053..4454346 1 NC_011741.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 4454346 groES 7125398 groES Escherichia coli IAI1 co-chaperonin GroES YP_002389609.1 4454053 D 585034 CDS YP_002389610.1 218556696 7128466 4454390..4456036 1 NC_011741.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 4456036 groEL 7128466 groEL Escherichia coli IAI1 chaperonin GroEL YP_002389610.1 4454390 D 585034 CDS YP_002389611.1 218556697 7128465 4456174..4456527 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4456527 yjeI 7128465 yjeI Escherichia coli IAI1 hypothetical protein YP_002389611.1 4456174 D 585034 CDS YP_002389612.1 218556698 7125399 4456567..4456716 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4456716 7125399 ECIAI1_4378 Escherichia coli IAI1 hypothetical protein YP_002389612.1 4456567 D 585034 CDS YP_002389613.1 218556699 7125438 4456780..4457760 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 4457760 7125438 ECIAI1_4379 Escherichia coli IAI1 transposase, IS110 family YP_002389613.1 4456780 D 585034 CDS YP_002389614.1 218556700 7125439 complement(4458009..4458878) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4458878 yjeJ 7125439 yjeJ Escherichia coli IAI1 hypothetical protein YP_002389614.1 4458009 R 585034 CDS YP_002389615.1 218556701 7125400 complement(4459268..4460296) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019591, 10629195; Product type pe : putative enzyme; putative lysine aminomutase 4460296 yjeK 7125400 yjeK Escherichia coli IAI1 putative lysine aminomutase YP_002389615.1 4459268 R 585034 CDS YP_002389616.1 218556702 7125401 4460338..4460904 1 NC_011741.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 4460904 efp 7125401 efp Escherichia coli IAI1 elongation factor P YP_002389616.1 4460338 D 585034 CDS YP_002389617.1 218556703 7125053 4460956..4461081 1 NC_011741.1 acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex; entericidin A 4461081 ecnA 7125053 ecnA Escherichia coli IAI1 entericidin A YP_002389617.1 4460956 D 585034 CDS YP_002389618.1 218556704 7125044 complement(4461176..4461427) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 4461427 7125044 ECIAI1_4384 Escherichia coli IAI1 hypothetical protein YP_002389618.1 4461176 R 585034 CDS YP_002389619.1 218556705 7125440 4461513..4461830 1 NC_011741.1 member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations; quaternary ammonium compound-resistance protein SugE 4461830 sugE 7125440 sugE Escherichia coli IAI1 quaternary ammonium compound-resistance protein SugE YP_002389619.1 4461513 D 585034 CDS YP_002389620.1 218556706 7126199 complement(4461827..4462360) 1 NC_011741.1 lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc 4462360 blc 7126199 blc Escherichia coli IAI1 outer membrane lipoprotein Blc YP_002389620.1 4461827 R 585034 CDS YP_002389621.1 218556707 7124416 complement(4462449..4463582) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92212899, 97464439, 99421326, 10595535, 6795623, 7041115, 9819201; Product type e : enzyme; beta-lactamase 4463582 ampC 7124416 ampC Escherichia coli IAI1 beta-lactamase YP_002389621.1 4462449 R 585034 CDS YP_002389622.1 218556708 7125756 complement(4463645..4464004) 1 NC_011741.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 4464004 frdD 7125756 frdD Escherichia coli IAI1 fumarate reductase subunit D YP_002389622.1 4463645 R 585034 CDS YP_002389623.1 218556709 7127273 complement(4464015..4464410) 1 NC_011741.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C 4464410 frdC 7127273 frdC Escherichia coli IAI1 fumarate reductase subunit C YP_002389623.1 4464015 R 585034 CDS YP_002389624.1 218556710 7127272 complement(4464421..4465155) 1 NC_011741.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit 4465155 frdB 7127272 frdB Escherichia coli IAI1 fumarate reductase iron-sulfur subunit YP_002389624.1 4464421 R 585034 CDS YP_002389625.1 218556711 7127271 complement(4465148..4466956) 1 NC_011741.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 4466956 frdA 7127271 frdA Escherichia coli IAI1 fumarate reductase flavoprotein subunit YP_002389625.1 4465148 R 585034 CDS YP_002389626.1 218556712 7127270 4467281..4468258 1 NC_011741.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 4468258 poxA 7127270 poxA Escherichia coli IAI1 lysyl-tRNA synthetase YP_002389626.1 4467281 D 585034 CDS YP_002389627.1 218556713 7126122 4468477..4469979 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4469979 yjeM 7126122 yjeM Escherichia coli IAI1 putative transporter YP_002389627.1 4468477 D 585034 CDS YP_002389628.1 218556714 7125402 complement(4470130..4473453) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 4473453 yjeP 7125402 yjeP Escherichia coli IAI1 hypothetical protein YP_002389628.1 4470130 R 585034 CDS YP_002389629.1 218556715 7125403 complement(4473475..4474443) 1 NC_011741.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 4474443 psd 7125403 psd Escherichia coli IAI1 phosphatidylserine decarboxylase YP_002389629.1 4473475 R 585034 CDS YP_002389630.1 218556716 7126172 complement(4474540..4475592) 1 NC_011741.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 4475592 rsgA 7126172 rsgA Escherichia coli IAI1 ribosome-associated GTPase YP_002389630.1 4474540 R 585034 CDS YP_002389631.1 218556717 7128436 4475687..4476232 1 NC_011741.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4476232 orn 7128436 orn Escherichia coli IAI1 oligoribonuclease YP_002389631.1 4475687 D 585034 CDS YP_002389632.1 218556718 7128026 complement(4477011..4478150) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative Fe-S electron transport protein 4478150 yjeS 7128026 yjeS Escherichia coli IAI1 putative Fe-S electron transport protein YP_002389632.1 4477011 R 585034 CDS YP_002389633.1 218556719 7125404 4478149..4479696 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 4479696 yjeF 7125404 yjeF Escherichia coli IAI1 hypothetical protein YP_002389633.1 4478149 D 585034 CDS YP_002389634.1 218556720 7125397 4479668..4480129 1 NC_011741.1 possibly involved in cell wall synthesis; putative ATPase 4480129 yjeE 7125397 yjeE Escherichia coli IAI1 putative ATPase YP_002389634.1 4479668 D 585034 CDS YP_002389635.1 218556721 7125396 4480148..4481485 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21348478, 87242501, 1594459, 7511774; Product type e : enzyme; N-acetylmuramoyl-l-alanine amidase II 4481485 amiB 7125396 amiB Escherichia coli IAI1 N-acetylmuramoyl-l-alanine amidase II YP_002389635.1 4480148 D 585034 CDS YP_002389636.1 218556722 7125753 4481495..4483342 1 NC_011741.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 4483342 mutL 7125753 mutL Escherichia coli IAI1 DNA mismatch repair protein YP_002389636.1 4481495 D 585034 CDS YP_002389637.1 218556723 7124503 4483335..4484285 1 NC_011741.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 4484285 miaA 7124503 miaA Escherichia coli IAI1 tRNA delta(2)-isopentenylpyrophosphate transferase YP_002389637.1 4483335 D 585034 CDS YP_002389638.1 218556724 7124270 4484371..4484679 1 NC_011741.1 Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 4484679 hfq 7124270 hfq Escherichia coli IAI1 RNA-binding protein Hfq YP_002389638.1 4484371 D 585034 CDS YP_002389639.1 218556725 7128522 4484755..4486035 1 NC_011741.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; putative GTPase HflX 4486035 hflX 7128522 hflX Escherichia coli IAI1 putative GTPase HflX YP_002389639.1 4484755 D 585034 CDS YP_002389640.1 218556726 7128521 4486121..4487380 1 NC_011741.1 with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 4487380 hflK 7128521 hflK Escherichia coli IAI1 FtsH protease regulator HflK YP_002389640.1 4486121 D 585034 CDS YP_002389641.1 218556727 7128520 4487383..4488387 1 NC_011741.1 with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 4488387 hflC 7128520 hflC Escherichia coli IAI1 FtsH protease regulator HflC YP_002389641.1 4487383 D 585034 CDS YP_002389642.1 218556728 7128518 4488469..4488666 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4488666 yjeT 7128518 yjeT Escherichia coli IAI1 hypothetical protein YP_002389642.1 4488469 D 585034 CDS YP_002389643.1 218556729 7125405 4488770..4490068 1 NC_011741.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 4490068 purA 7125405 purA Escherichia coli IAI1 adenylosuccinate synthetase YP_002389643.1 4488770 D 585034 CDS YP_002389644.1 218556730 7126544 4490273..4490698 1 NC_011741.1 negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 4490698 nsrR 7126544 nsrR Escherichia coli IAI1 transcriptional repressor NsrR YP_002389644.1 4490273 D 585034 CDS YP_002389645.1 218556731 7125949 4490737..4493178 1 NC_011741.1 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 4493178 rnr 7125949 rnr Escherichia coli IAI1 exoribonuclease R YP_002389645.1 4490737 D 585034 CDS YP_002389646.1 218556732 7128611 4493358..4494089 1 NC_011741.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 4494089 rlmB 7128611 rlmB Escherichia coli IAI1 23S rRNA (guanosine-2'-O-)-methyltransferase YP_002389646.1 4493358 D 585034 CDS YP_002389647.1 218556733 7125006 4494216..4494617 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4494617 yjfI 7125006 yjfI Escherichia coli IAI1 hypothetical protein YP_002389647.1 4494216 D 585034 CDS YP_002389648.1 218556734 7125408 4494636..4495334 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator effector protein 4495334 yjfJ 7125408 yjfJ Escherichia coli IAI1 putative transcriptional regulator effector protein YP_002389648.1 4494636 D 585034 CDS YP_002389649.1 218556735 7125409 4495385..4496044 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4496044 yjfK 7125409 yjfK Escherichia coli IAI1 hypothetical protein YP_002389649.1 4495385 D 585034 CDS YP_002389650.1 218556736 7125410 4496062..4496460 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4496460 yjfL 7125410 yjfL Escherichia coli IAI1 hypothetical protein YP_002389650.1 4496062 D 585034 CDS YP_002389651.1 218556737 7125411 4496470..4497108 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4497108 yjfM 7125411 yjfM Escherichia coli IAI1 hypothetical protein YP_002389651.1 4496470 D 585034 CDS YP_002389652.1 218556738 7125412 4497111..4498274 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative synthetase/amidase 4498274 yjfC 7125412 yjfC Escherichia coli IAI1 putative synthetase/amidase YP_002389652.1 4497111 D 585034 CDS YP_002389653.1 218556739 7125406 4498358..4499983 1 NC_011741.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 4499983 aidB 7125406 aidB Escherichia coli IAI1 isovaleryl CoA dehydrogenase YP_002389653.1 4498358 D 585034 CDS YP_002389654.1 218556740 7125738 complement(4500100..4500375) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4500375 yjfN 7125738 yjfN Escherichia coli IAI1 hypothetical protein YP_002389654.1 4500100 R 585034 CDS YP_002389655.1 218556741 7125413 complement(4500524..4500853) 1 NC_011741.1 in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility; putative biofilm stress and motility protein A 4500853 yjfO 7125413 yjfO Escherichia coli IAI1 putative biofilm stress and motility protein A YP_002389655.1 4500524 R 585034 CDS YP_002389656.1 218556742 7125414 4501035..4501784 1 NC_011741.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 4501784 yjfP 7125414 yjfP Escherichia coli IAI1 esterase YP_002389656.1 4501035 D 585034 CDS YP_002389657.1 218556743 7125415 complement(4501781..4502536) 1 NC_011741.1 negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR 4502536 ulaR 7125415 ulaR Escherichia coli IAI1 transcriptional repressor UlaR YP_002389657.1 4501781 R 585034 CDS YP_002389658.1 218556744 7125542 complement(4502644..4503708) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12644495, 15808744; Product type pe : putative enzyme; putative L-ascorbate 6-phosphate lactonase 4503708 ulaG 7125542 ulaG Escherichia coli IAI1 putative L-ascorbate 6-phosphate lactonase YP_002389658.1 4502644 R 585034 CDS YP_002389659.1 218556745 7125541 4504063..4505460 1 NC_011741.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 4505460 ulaA 7125541 ulaA Escherichia coli IAI1 PTS system ascorbate-specific transporter subunit IIC YP_002389659.1 4504063 D 585034 CDS YP_002389660.1 218556746 7125535 4505476..4505781 1 NC_011741.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIB 4505781 ulaB 7125535 ulaB Escherichia coli IAI1 PTS system L-ascorbate-specific transporter subunit IIB YP_002389660.1 4505476 D 585034 CDS YP_002389661.1 218556747 7125536 4505791..4506255 1 NC_011741.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIA 4506255 ulaC 7125536 ulaC Escherichia coli IAI1 PTS system L-ascorbate-specific transporter subunit IIA YP_002389661.1 4505791 D 585034 CDS YP_002389662.1 218556748 7125537 4506269..4506919 1 NC_011741.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 4506919 ulaD 7125537 ulaD Escherichia coli IAI1 3-keto-L-gulonate-6-phosphate decarboxylase YP_002389662.1 4506269 D 585034 CDS YP_002389663.1 218556749 7125538 4506929..4507783 1 NC_011741.1 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 4507783 ulaE 7125538 ulaE Escherichia coli IAI1 L-xylulose 5-phosphate 3-epimerase YP_002389663.1 4506929 D 585034 CDS YP_002389664.1 218556750 7125539 4507783..4508469 1 NC_011741.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4508469 sgaE 7125539 sgaE Escherichia coli IAI1 L-ribulose-5-phosphate 4-epimerase YP_002389664.1 4507783 D 585034 CDS YP_002389665.1 218556751 7125540 complement(4508599..4508874) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4508874 yjfY 7125540 yjfY Escherichia coli IAI1 hypothetical protein YP_002389665.1 4508599 R 585034 CDS YP_002389666.1 218556752 7125416 4509201..4509596 1 NC_011741.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 4509596 rpsF 7125416 rpsF Escherichia coli IAI1 30S ribosomal protein S6 YP_002389666.1 4509201 D 585034 CDS YP_002389667.1 218556753 7128412 4509603..4509917 1 NC_011741.1 binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 4509917 priB 7128412 priB Escherichia coli IAI1 primosomal replication protein N YP_002389667.1 4509603 D 585034 CDS YP_002389668.1 218556754 7126149 4509922..4510149 1 NC_011741.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4510149 rpsR 7126149 rpsR Escherichia coli IAI1 30S ribosomal protein S18 YP_002389668.1 4509922 D 585034 CDS YP_002389669.1 218556755 7128424 4510191..4510640 1 NC_011741.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4510640 rplI 7128424 rplI Escherichia coli IAI1 50S ribosomal protein L9 YP_002389669.1 4510191 D 585034 CDS YP_002389670.1 218556756 7128370 complement(4510711..4511505) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4511505 yjfZ 7128370 yjfZ Escherichia coli IAI1 hypothetical protein YP_002389670.1 4510711 R 585034 CDS YP_002389671.1 218556757 7125417 complement(4512128..4512559) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase 4512559 7125417 ECIAI1_4438 Escherichia coli IAI1 transposase YP_002389671.1 4512128 R 585034 CDS YP_002389672.1 218556758 7125441 4512567..4513775 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase 4513775 ydcM 7125441 ydcM Escherichia coli IAI1 putative transposase YP_002389672.1 4512567 D 585034 CDS YP_002389673.1 218556759 7127382 complement(4513910..4514548) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8559074; Product type ps : putative structure; putative cell envelope opacity-associated protein 4514548 ytfB 7127382 ytfB Escherichia coli IAI1 putative cell envelope opacity-associated protein YP_002389673.1 4513910 R 585034 CDS YP_002389674.1 218556760 7128106 4514767..4515387 1 NC_011741.1 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 4515387 fklB 7128106 fklB Escherichia coli IAI1 peptidyl-prolyl cis-trans isomerase YP_002389674.1 4514767 D 585034 CDS YP_002389675.1 218556761 7127206 4515696..4517108 1 NC_011741.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 4517108 cycA 7127206 cycA Escherichia coli IAI1 D-alanine/D-serine/glycine permease YP_002389675.1 4515696 D 585034 CDS YP_002389676.1 218556762 7126873 complement(4517153..4517815) 1 NC_011741.1 Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein 4517815 ytfE 7126873 ytfE Escherichia coli IAI1 iron-sulfur cluster repair di-iron protein YP_002389676.1 4517153 R 585034 CDS YP_002389677.1 218556763 7128107 complement(4517923..4518897) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4518897 ytfF 7128107 ytfF Escherichia coli IAI1 hypothetical protein YP_002389677.1 4517923 R 585034 CDS YP_002389678.1 218556764 7128108 complement(4518996..4519856) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14747727; Product type e : enzyme; NAD(P)H:quinone oxidoreductase 4519856 ytfG 7128108 ytfG Escherichia coli IAI1 NAD(P)H:quinone oxidoreductase YP_002389678.1 4518996 R 585034 CDS YP_002389679.1 218556765 7128109 4519945..4520325 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20088838; Product type pr : putative regulator; putative transcriptional regulator 4520325 ytfH 7128109 ytfH Escherichia coli IAI1 putative transcriptional regulator YP_002389679.1 4519945 D 585034 CDS YP_002389680.1 218556766 7128110 complement(4520454..4522397) 1 NC_011741.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein 4522397 cpdB 7128110 cpdB Escherichia coli IAI1 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein YP_002389680.1 4520454 R 585034 CDS YP_002389681.1 218556767 7126355 4522587..4523327 1 NC_011741.1 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 4523327 cysQ 7126355 cysQ Escherichia coli IAI1 adenosine-3'(2'),5'-bisphosphate nucleotidase YP_002389681.1 4522587 D 585034 CDS YP_002389682.1 218556768 7126900 complement(4523317..4523874) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pr : putative regulator; putative transcriptional regulator 4523874 ytfJ 7126900 ytfJ Escherichia coli IAI1 putative transcriptional regulator YP_002389682.1 4523317 R 585034 CDS YP_002389683.1 218556769 7128111 4524199..4524405 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4524405 ytfK 7128111 ytfK Escherichia coli IAI1 hypothetical protein YP_002389683.1 4524199 D 585034 CDS YP_002389684.1 218556770 7128112 complement(4524467..4525810) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4525810 ytfL 7128112 ytfL Escherichia coli IAI1 hypothetical protein YP_002389684.1 4524467 R 585034 CDS YP_002389685.1 218556771 7128113 complement(4526133..4526771) 1 NC_011741.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 4526771 msrA 7128113 msrA Escherichia coli IAI1 methionine sulfoxide reductase A YP_002389685.1 4526133 R 585034 CDS YP_002389686.1 218556772 7124481 4526977..4528710 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4528710 ytfM 7124481 ytfM Escherichia coli IAI1 hypothetical protein YP_002389686.1 4526977 D 585034 CDS YP_002389687.1 218556773 7128114 4528707..4532486 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4532486 ytfN 7128114 ytfN Escherichia coli IAI1 hypothetical protein YP_002389687.1 4528707 D 585034 CDS YP_002389688.1 218556774 7128115 4532489..4532830 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4532830 ytfP 7128115 ytfP Escherichia coli IAI1 hypothetical protein YP_002389688.1 4532489 D 585034 CDS YP_002389689.1 218556775 7128116 4533042..4533293 1 NC_011741.1 part of the toxin-antitoxin ChpB-ChpS system; antitoxin ChpS 4533293 chpS 7128116 chpS Escherichia coli IAI1 antitoxin ChpS YP_002389689.1 4533042 D 585034 CDS YP_002389690.1 218556776 7126318 4533287..4533637 1 NC_011741.1 toxin of the ChpB-ChpS toxin-antitoxin system; toxin ChpB 4533637 chpB 7126318 chpB Escherichia coli IAI1 toxin ChpB YP_002389690.1 4533287 D 585034 CDS YP_002389691.1 218556777 7126316 complement(4533717..4534247) 1 NC_011741.1 catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 4534247 ppa 7126316 ppa Escherichia coli IAI1 inorganic pyrophosphatase YP_002389691.1 4533717 R 585034 CDS YP_002389692.1 218556778 7126124 4534557..4535513 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pt : putative transporter; putative sugar ABC transporter periplasmic-binding protein 4535513 ytfQ 7126124 ytfQ Escherichia coli IAI1 putative sugar ABC transporter periplasmic-binding protein YP_002389692.1 4534557 D 585034 CDS YP_002389693.1 218556779 7128117 4535653..4537155 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter ATP-binding protein 4537155 ytfR 7128117 ytfR Escherichia coli IAI1 putative sugar ABC transporter ATP-binding protein YP_002389693.1 4535653 D 585034 CDS YP_002389694.1 218556780 7128118 4537169..4538191 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter membrane protein 4538191 ytfT 7128118 ytfT Escherichia coli IAI1 putative sugar ABC transporter membrane protein YP_002389694.1 4537169 D 585034 CDS YP_002389695.1 218556781 7128119 4538178..4539173 1 NC_011741.1 membrane component of a putative sugar ABC transporter system; inner membrane ABC transporter permease YjfF 4539173 yjfF 7128119 yjfF Escherichia coli IAI1 inner membrane ABC transporter permease YjfF YP_002389695.1 4538178 D 585034 CDS YP_002389696.1 218556782 7125407 complement(4539206..4540204) 1 NC_011741.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 4540204 fbp 7125407 fbp Escherichia coli IAI1 fructose-1,6-bisphosphatase YP_002389696.1 4539206 R 585034 CDS YP_002389697.1 218556783 7127070 4540380..4541753 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96404780, 2843822, 7984428, 8808921; Product type e : enzyme; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 4541753 mpl 7127070 mpl Escherichia coli IAI1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase YP_002389697.1 4540380 D 585034 CDS YP_002389698.1 218556784 7124463 complement(4541904..4542455) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4542455 yjgA 7124463 yjgA Escherichia coli IAI1 hypothetical protein YP_002389698.1 4541904 R 585034 CDS YP_002389699.1 218556785 7125418 4542549..4543901 1 NC_011741.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 4543901 pmbA 7125418 pmbA Escherichia coli IAI1 peptidase PmbA YP_002389699.1 4542549 D 585034 CDS YP_002389700.1 218556786 7126103 4544084..4544470 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1761034, 8499452, 10393541; Product type c : carrier; soluble cytochrome b562 4544470 cybC 7126103 cybC Escherichia coli IAI1 soluble cytochrome b562 YP_002389700.1 4544084 D 585034 CDS YP_002389701.1 218556787 7126872 complement(4544515..4544979) 1 NC_011741.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein 4544979 nrdG 7126872 nrdG Escherichia coli IAI1 anaerobic ribonucleotide reductase-activating protein YP_002389701.1 4544515 R 585034 CDS YP_002389702.1 218556788 7125938 complement(4545137..4547275) 1 NC_011741.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 4547275 nrdD 7125938 nrdD Escherichia coli IAI1 anaerobic ribonucleoside triphosphate reductase YP_002389702.1 4545137 R 585034 CDS YP_002389703.1 218556789 7127902 complement(4547669..4549324) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264345, 93302496, 8083158, 8421692; Product type e : enzyme; trehalose-6-phosphate hydrolase 4549324 treC 7127902 treC Escherichia coli IAI1 trehalose-6-phosphate hydrolase YP_002389703.1 4547669 R 585034 CDS YP_002389704.1 218556790 7127481 complement(4549374..4550795) 1 NC_011741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system trehalose(maltose)-specific transporter subunits IIBC 4550795 treB 7127481 treB Escherichia coli IAI1 PTS system trehalose(maltose)-specific transporter subunits IIBC YP_002389704.1 4549374 R 585034 CDS YP_002389705.1 218556791 7127480 complement(4550914..4551861) 1 NC_011741.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor 4551861 treR 7127480 treR Escherichia coli IAI1 trehalose repressor YP_002389705.1 4550914 R 585034 CDS YP_002389706.1 218556792 7127483 4552240..4554936 1 NC_011741.1 P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 4554936 mgtA 7127483 mgtA Escherichia coli IAI1 magnesium-transporting ATPase MgtA YP_002389706.1 4552240 D 585034 CDS YP_002389707.1 218556793 7124261 complement(4555142..4555528) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12515541, 10493123, 10595546, 9298646; Product type pe : putative enzyme; ketoacid-binding protein 4555528 yjgF 7124261 yjgF Escherichia coli IAI1 ketoacid-binding protein YP_002389707.1 4555142 R 585034 CDS YP_002389708.1 218556794 7125421 complement(4555601..4556062) 1 NC_011741.1 involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase regulatory subunit 4556062 pyrI 7125421 pyrI Escherichia coli IAI1 aspartate carbamoyltransferase regulatory subunit YP_002389708.1 4555601 R 585034 CDS YP_002389709.1 218556795 7126576 complement(4556075..4557010) 1 NC_011741.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 4557010 pyrB 7126576 pyrB Escherichia coli IAI1 aspartate carbamoyltransferase catalytic subunit YP_002389709.1 4556075 R 585034 CDS YP_002389710.1 218556796 7126569 complement(4557014..4557148) 1 NC_011741.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; pyrBI operon leader peptide 4557148 pyrL 7126569 pyrL Escherichia coli IAI1 pyrBI operon leader peptide YP_002389710.1 4557014 R 585034 CDS YP_002389711.1 218556797 7126577 complement(4557429..4557824) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative mRNA endoribonuclease 4557824 yjgH 7126577 yjgH Escherichia coli IAI1 putative mRNA endoribonuclease YP_002389711.1 4557429 R 585034 CDS YP_002389712.1 218556798 7125422 complement(4557955..4558668) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; oxidoreductase 4558668 yjgI 7125422 yjgI Escherichia coli IAI1 oxidoreductase YP_002389712.1 4557955 R 585034 CDS YP_002389713.1 218556799 7125423 4558739..4559332 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4559332 yjgJ 7125423 yjgJ Escherichia coli IAI1 putative transcriptional regulator YP_002389713.1 4558739 D 585034 CDS YP_002389714.1 218556800 7125424 4559477..4559929 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11115104; hypothetical protein 4559929 yjgK 7125424 yjgK Escherichia coli IAI1 hypothetical protein YP_002389714.1 4559477 D 585034 CDS YP_002389715.1 218556801 7126446 complement(4561712..4562716) 1 NC_011741.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.; ornithine carbamoyltransferase subunit I 4562716 argI 7126446 argI Escherichia coli IAI1 ornithine carbamoyltransferase subunit I YP_002389715.1 4561712 R 585034 CDS YP_002389716.1 218556802 7125793 4562878..4563294 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4563294 yjgD 7125793 yjgD Escherichia coli IAI1 hypothetical protein YP_002389716.1 4562878 D 585034 CDS YP_002389717.1 218556803 7125420 complement(4563340..4563843) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase 4563843 yjgM 7125420 yjgM Escherichia coli IAI1 putative acetyltransferase YP_002389717.1 4563340 R 585034 CDS YP_002389718.1 218556804 7126607 4564036..4565232 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4565232 yjgN 7126607 yjgN Escherichia coli IAI1 hypothetical protein YP_002389718.1 4564036 D 585034 CDS YP_002389719.1 218556805 7126608 complement(4565288..4568143) 1 NC_011741.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 4568143 valS 7126608 valS Escherichia coli IAI1 valyl-tRNA synthetase YP_002389719.1 4565288 R 585034 CDS YP_002389720.1 218556806 7125567 complement(4568143..4568586) 1 NC_011741.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 4568586 holC 7125567 holC Escherichia coli IAI1 DNA polymerase III subunit chi YP_002389720.1 4568143 R 585034 CDS YP_002389721.1 218556807 7125293 complement(4568720..4570231) 1 NC_011741.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 4570231 pepA 7125293 pepA Escherichia coli IAI1 leucyl aminopeptidase YP_002389721.1 4568720 R 585034 CDS YP_002389722.1 218556808 7124169 4570498..4571598 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4571598 yjgP 7124169 yjgP Escherichia coli IAI1 hypothetical protein YP_002389722.1 4570498 D 585034 CDS YP_002389723.1 218556809 7126609 4571598..4572680 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4572680 yjgQ 7126609 yjgQ Escherichia coli IAI1 hypothetical protein YP_002389723.1 4571598 D 585034 CDS YP_002389724.1 218556810 7126610 complement(4572799..4574301) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATPase 4574301 yjgR 7126610 yjgR Escherichia coli IAI1 putative ATPase YP_002389724.1 4572799 R 585034 CDS YP_002389725.1 218556811 7126611 complement(4574431..4575450) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12147722; Product type pe : putative enzyme; putative alcohol dehydrogenase 4575450 yjgB 7126611 yjgB Escherichia coli IAI1 putative alcohol dehydrogenase YP_002389725.1 4574431 R 585034 CDS YP_002389726.1 218556812 7125419 complement(4575525..4575731) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4575731 7125419 ECIAI1_4496 Escherichia coli IAI1 hypothetical protein YP_002389726.1 4575525 R 585034 CDS YP_002389727.1 218556813 7128028 4575920..4577170 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2403440; Product type h : extrachromosomal origin; Prophage integrase 4577170 int 7128028 int Escherichia coli IAI1 Prophage integrase YP_002389727.1 4575920 D 585034 CDS YP_002389728.1 218556814 7126072 4577258..4578397 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10671450; Product type pe : putative enzyme; putative modification methylase NmeDIP 4578397 7126072 ECIAI1_4498 Escherichia coli IAI1 putative modification methylase NmeDIP YP_002389728.1 4577258 D 585034 CDS YP_002389729.1 218556815 7125443 4578333..4579409 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10671450; Product type pe : putative enzyme; putative type II restriction enzyme NmeDIP 4579409 7125443 ECIAI1_4499 Escherichia coli IAI1 putative type II restriction enzyme NmeDIP YP_002389729.1 4578333 D 585034 CDS YP_002389730.1 218556816 7125444 4579551..4580360 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4580360 7125444 ECIAI1_4500 Escherichia coli IAI1 hypothetical protein YP_002389730.1 4579551 D 585034 CDS YP_002389731.1 218556817 7125445 4580526..4580732 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage DNA binding protein 4580732 alpA 7125445 alpA Escherichia coli IAI1 putative phage DNA binding protein YP_002389731.1 4580526 D 585034 CDS YP_002389732.1 218556818 7125750 4580738..4581067 1 NC_011741.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4581067 7125750 ECIAI1_4502 Escherichia coli IAI1 hypothetical protein YP_002389732.1 4580738 D 585034 CDS YP_002389733.1 218556819 7125446 4581350..4582552 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative integrase 4582552 7125446 ECIAI1_4503 Escherichia coli IAI1 putative integrase YP_002389733.1 4581350 D 585034 CDS YP_002389734.1 218556820 7125447 4582485..4583849 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative integrase 4583849 7125447 ECIAI1_4504 Escherichia coli IAI1 putative integrase YP_002389734.1 4582485 D 585034 CDS YP_002389735.1 218556821 7125448 4583846..4585720 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative integrase 4585720 7125448 ECIAI1_4505 Escherichia coli IAI1 putative integrase YP_002389735.1 4583846 D 585034 CDS YP_002389736.1 218556822 7125449 4585735..4586121 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4586121 7125449 ECIAI1_4506 Escherichia coli IAI1 hypothetical protein YP_002389736.1 4585735 D 585034 CDS YP_002389737.1 218556823 7125450 4586209..4586643 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4586643 7125450 ECIAI1_4507 Escherichia coli IAI1 hypothetical protein YP_002389737.1 4586209 D 585034 CDS YP_002389738.1 218556824 7125451 complement(4586697..4587011) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4587011 7125451 ECIAI1_4508 Escherichia coli IAI1 hypothetical protein YP_002389738.1 4586697 R 585034 CDS YP_002389739.1 218556825 7125452 complement(4587030..4587416) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4587416 7125452 ECIAI1_4509 Escherichia coli IAI1 hypothetical protein YP_002389739.1 4587030 R 585034 CDS YP_002389740.1 218556826 7125453 complement(4587458..4587730) 1 NC_011741.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4587730 7125453 ECIAI1_4510 Escherichia coli IAI1 hypothetical protein YP_002389740.1 4587458 R 585034 CDS YP_002389741.1 218556827 7125454 complement(4587954..4589162) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4589162 7125454 ECIAI1_4511 Escherichia coli IAI1 hypothetical protein YP_002389741.1 4587954 R 585034 CDS YP_002389742.1 218556828 7125455 complement(4589122..4589562) 1 NC_011741.1 hypothetical protein 4589562 7125455 ECIAI1_4513 Escherichia coli IAI1 hypothetical protein YP_002389742.1 4589122 R 585034 CDS YP_002389743.1 218556829 7125456 4589742..4590224 1 NC_011741.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4590224 7125456 ECIAI1_4514 Escherichia coli IAI1 hypothetical protein YP_002389743.1 4589742 D 585034 CDS YP_002389744.1 218556830 7125457 4590263..4590778 1 NC_011741.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4590778 7125457 ECIAI1_4515 Escherichia coli IAI1 hypothetical protein YP_002389744.1 4590263 D 585034 CDS YP_002389745.1 218556831 7125458 complement(4590879..4591808) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4591808 7125458 ECIAI1_4516 Escherichia coli IAI1 hypothetical protein YP_002389745.1 4590879 R 585034 CDS YP_002389746.1 218556832 7125459 4591949..4592113 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 4592113 7125459 ECIAI1_4517 Escherichia coli IAI1 hypothetical protein YP_002389746.1 4591949 D 585034 CDS YP_002389747.1 218556833 7125460 complement(4592202..4593098) 1 NC_011741.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4593098 7125460 ECIAI1_4518 Escherichia coli IAI1 hypothetical protein YP_002389747.1 4592202 R 585034 CDS YP_002389748.1 218556834 7125461 complement(4593108..4594265) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4594265 7125461 ECIAI1_4519 Escherichia coli IAI1 hypothetical protein YP_002389748.1 4593108 R 585034 CDS YP_002389749.1 218556835 7125462 complement(4594262..4596178) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4596178 7125462 ECIAI1_4520 Escherichia coli IAI1 hypothetical protein YP_002389749.1 4594262 R 585034 CDS YP_002389750.1 218556836 7125463 4596824..4597069 1 NC_011741.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4597069 7125463 ECIAI1_4521 Escherichia coli IAI1 hypothetical protein YP_002389750.1 4596824 D 585034 CDS YP_002389751.1 218556837 7125464 complement(4597258..4598238) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4598238 yjhS 7125464 yjhS Escherichia coli IAI1 hypothetical protein YP_002389751.1 4597258 R 585034 CDS YP_002389752.1 218556838 7126613 complement(4598303..4599409) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; N-acetylneuraminic acid mutarotase 4599409 yjhT 7126613 yjhT Escherichia coli IAI1 N-acetylneuraminic acid mutarotase YP_002389752.1 4598303 R 585034 CDS YP_002389753.1 218556839 7126614 complement(4599429..4600145) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15743943; Product type t : transporter; N-acetylnuraminic acid outer membrane channel protein 4600145 yjhA 7126614 yjhA Escherichia coli IAI1 N-acetylnuraminic acid outer membrane channel protein YP_002389753.1 4599429 R 585034 CDS YP_002389754.1 218556840 7126612 4600515..4600718 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 4600718 7126612 ECIAI1_4525 Escherichia coli IAI1 hypothetical protein YP_002389754.1 4600515 D 585034 CDS YP_002389755.1 218556841 7125465 complement(4600787..4600948) 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 4600948 7125465 ECIAI1_4526 Escherichia coli IAI1 hypothetical protein YP_002389755.1 4600787 R 585034 CDS YP_002389756.1 218556842 7125466 complement(4600945..4601340) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4601340 7125466 ECIAI1_4527 Escherichia coli IAI1 hypothetical protein YP_002389756.1 4600945 R 585034 CDS YP_002389757.1 218556843 7125467 4601601..4602203 1 NC_011741.1 inversion of on/off regulator of fimA; tyrosine recombinase 4602203 fimB 7125467 fimB Escherichia coli IAI1 tyrosine recombinase YP_002389757.1 4601601 D 585034 CDS YP_002389758.1 218556844 7127111 4602681..4603277 1 NC_011741.1 inversion of on/off regulator of fimA; tyrosine recombinase 4603277 fimE 7127111 fimE Escherichia coli IAI1 tyrosine recombinase YP_002389758.1 4602681 D 585034 CDS YP_002389759.1 218556845 7127114 4603757..4604305 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6146599, 6147250, 90220509, 93106965, 2858471, 6123483; Product type s : structure; major type 1 subunit fimbrin 4604305 fimA 7127114 fimA Escherichia coli IAI1 major type 1 subunit fimbrin YP_002389759.1 4603757 D 585034 CDS YP_002389760.1 218556846 7127110 4604370..4604909 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12897022, 11673421, 6147250; Product type s : structure; type 1 pilus biosynthesis fimbrial protein 4604909 fimI 7127110 fimI Escherichia coli IAI1 type 1 pilus biosynthesis fimbrial protein YP_002389760.1 4604370 D 585034 CDS YP_002389761.1 218556847 7127118 4604946..4605671 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20450729, 90220509, 93155127, 93391362, 1363735, 8104335, 8636962, 9783748; Product type f : factor; chaperone, periplasmic 4605671 fimC 7127118 fimC Escherichia coli IAI1 chaperone, periplasmic YP_002389761.1 4604946 D 585034 CDS YP_002389762.1 218556848 7127112 4605738..4608374 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12842468, 90220509, 1970114; Product type f : factor; outer membrane usher protein, type 1 fimbrial synthesis 4608374 fimD 7127112 fimD Escherichia coli IAI1 outer membrane usher protein, type 1 fimbrial synthesis YP_002389762.1 4605738 D 585034 CDS YP_002389763.1 218556849 7127113 4608384..4608914 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 92394896, 1970114, 2890081; Product type s : structure; minor component of type 1 fimbriae 4608914 fimF 7127113 fimF Escherichia coli IAI1 minor component of type 1 fimbriae YP_002389763.1 4608384 D 585034 CDS YP_002389764.1 218556850 7127115 4608927..4609430 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 92394896, 2890081; Product type s : structure; minor component of type 1 fimbriae 4609430 fimG 7127115 fimG Escherichia coli IAI1 minor component of type 1 fimbriae YP_002389764.1 4608927 D 585034 CDS YP_002389765.1 218556851 7127116 4609450..4610352 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 93155127, 93391362, 1971261, 2890081, 2900235; Product type s : structure; minor component of type 1 fimbriae 4610352 fimH 7127116 fimH Escherichia coli IAI1 minor component of type 1 fimbriae YP_002389765.1 4609450 D 585034 CDS YP_002389766.1 218556852 7127117 complement(4610595..4611938) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96125229, 15516583, 8550444; Product type t : transporter; fructuronate transporter 4611938 gntP 7127117 gntP Escherichia coli IAI1 fructuronate transporter YP_002389766.1 4610595 R 585034 CDS YP_002389767.1 218556853 7128450 4612278..4613462 1 NC_011741.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 4613462 uxuA 7128450 uxuA Escherichia coli IAI1 mannonate dehydratase YP_002389767.1 4612278 D 585034 CDS YP_002389768.1 218556854 7125563 4613543..4615003 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73203083, 77222076, 14401695; Product type e : enzyme; D-mannonate oxidoreductase, NAD-binding 4615003 uxuB 7125563 uxuB Escherichia coli IAI1 D-mannonate oxidoreductase, NAD-binding YP_002389768.1 4613543 D 585034 CDS YP_002389769.1 218556855 7125564 4615218..4615991 1 NC_011741.1 regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 4615991 uxuR 7125564 uxuR Escherichia coli IAI1 DNA-binding transcriptional repressor UxuR YP_002389769.1 4615218 D 585034 CDS YP_002389770.1 218556856 7125565 complement(4616132..4616962) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4616962 yjiC 7125565 yjiC Escherichia coli IAI1 hypothetical protein YP_002389770.1 4616132 R 585034 CDS YP_002389771.1 218556857 7126616 4617526..4617669 1 NC_011741.1 Evidence 6 : Doubtful CDS; hypothetical protein 4617669 7126616 ECIAI1_4542 Escherichia coli IAI1 hypothetical protein YP_002389771.1 4617526 D 585034 CDS YP_002389772.1 218556858 7125468 4617635..4618027 1 NC_011741.1 inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS; DNA replication/recombination/repair protein 4618027 iraD 7125468 iraD Escherichia coli IAI1 DNA replication/recombination/repair protein YP_002389772.1 4617635 D 585034 CDS YP_002389773.1 218556859 7126617 complement(4618020..4618931) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4618931 yjiE 7126617 yjiE Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002389773.1 4618020 R 585034 CDS YP_002389774.1 218556860 7126618 complement(4618996..4620168) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95181377, 7876157; Product type e : enzyme; isoaspartyl dipeptidase 4620168 iadA 7126618 iadA Escherichia coli IAI1 isoaspartyl dipeptidase YP_002389774.1 4618996 R 585034 CDS YP_002389775.1 218556861 7126037 complement(4620181..4620642) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4620642 yjiG 7126037 yjiG Escherichia coli IAI1 hypothetical protein YP_002389775.1 4620181 R 585034 CDS YP_002389776.1 218556862 7126619 complement(4620639..4621322) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4621322 yjiH 7126619 yjiH Escherichia coli IAI1 hypothetical protein YP_002389776.1 4620639 R 585034 CDS YP_002389777.1 218556863 7126620 4621572..4622126 1 NC_011741.1 in yeast cells this enzyme removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate; functions in tRNA splicing; the function and substrate of bacterial enzymes in organisms that do not perform splicing is unknown; RNA 2'-phosphotransferase-like protein 4622126 kptA 7126620 kptA Escherichia coli IAI1 RNA 2'-phosphotransferase-like protein YP_002389777.1 4621572 D 585034 CDS YP_002389778.1 218556864 7126391 complement(4622139..4623317) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4623317 yjiJ 7126391 yjiJ Escherichia coli IAI1 hypothetical protein YP_002389778.1 4622139 R 585034 CDS YP_002389779.1 218556865 7126621 complement(4623385..4624353) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4624353 yjiK 7126621 yjiK Escherichia coli IAI1 hypothetical protein YP_002389779.1 4623385 R 585034 CDS YP_002389780.1 218556866 7126622 complement(4624310..4624567) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4624567 7126622 ECIAI1_4551 Escherichia coli IAI1 hypothetical protein YP_002389780.1 4624310 R 585034 CDS YP_002389781.1 218556867 7125469 complement(4624564..4625331) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8365476, 7607244, 15654892; Product type e : enzyme; ATPase, activator of (R)-hydroxyglutaryl-CoA dehydratase 4625331 hgdC 7125469 hgdC Escherichia coli IAI1 ATPase, activator of (R)-hydroxyglutaryl-CoA dehydratase YP_002389781.1 4624564 R 585034 CDS YP_002389782.1 218556868 7128523 complement(4625341..4626492) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3691501, 11106419; Product type pe : putative enzyme; putative 2-hydroxyglutaryl-CoA dehydratase 4626492 yjiM 7128523 yjiM Escherichia coli IAI1 putative 2-hydroxyglutaryl-CoA dehydratase YP_002389782.1 4625341 R 585034 CDS YP_002389783.1 218556869 7126623 complement(4626608..4627888) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4627888 yjiN 7126623 yjiN Escherichia coli IAI1 hypothetical protein YP_002389783.1 4626608 R 585034 CDS YP_002389784.1 218556870 7126624 complement(4627929..4629161) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803; Product type t : transporter; multidrug efflux system protein 4629161 yjiO 7126624 yjiO Escherichia coli IAI1 multidrug efflux system protein YP_002389784.1 4627929 R 585034 CDS YP_002389785.1 218556871 7126625 4629628..4630584 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4630584 7126625 ECIAI1_4557 Escherichia coli IAI1 hypothetical protein YP_002389785.1 4629628 D 585034 CDS YP_002389786.1 218556872 7125470 complement(4630827..4632239) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator/aminotransferase 4632239 yjiR 7125470 yjiR Escherichia coli IAI1 putative DNA-binding transcriptional regulator/aminotransferase YP_002389786.1 4630827 R 585034 CDS YP_002389787.1 218556873 7126626 4632382..4632534 1 NC_011741.1 hypothetical protein 4632534 7126626 ECIAI1_4559 Escherichia coli IAI1 hypothetical protein YP_002389787.1 4632382 D 585034 CDS YP_002389788.1 218556874 7125471 4632416..4632580 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4632580 yjiS 7125471 yjiS Escherichia coli IAI1 hypothetical protein YP_002389788.1 4632416 D 585034 CDS YP_002389789.1 218556875 7126627 4632932..4635472 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1472713, 15128530, 9292993; Product type e : enzyme; Penicillin G acylase 4635472 7126627 ECIAI1_4561 Escherichia coli IAI1 Penicillin G acylase YP_002389789.1 4632932 D 585034 CDS YP_002389790.1 218556876 7125472 complement(4635550..4636506) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14696199; Product type pe : putative enzyme; putative GTP-binding protein YjiA 4636506 yjiA 7125472 yjiA Escherichia coli IAI1 putative GTP-binding protein YjiA YP_002389790.1 4635550 R 585034 CDS YP_002389791.1 218556877 7126615 complement(4636517..4636720) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4636720 yjiX 7126615 yjiX Escherichia coli IAI1 hypothetical protein YP_002389791.1 4636517 R 585034 CDS YP_002389792.1 218556878 7126628 complement(4636770..4638920) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4638920 yjiY 7126628 yjiY Escherichia coli IAI1 hypothetical protein YP_002389792.1 4636770 R 585034 CDS YP_002389793.1 218556879 7126629 complement(4639088..4639234) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4639234 7126629 ECIAI1_4565 Escherichia coli IAI1 hypothetical protein YP_002389793.1 4639088 R 585034 CDS YP_002389794.1 218556880 7125473 complement(4639313..4639825) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8077235, 8550403, 10633095; Product type e : enzyme; 4-hydroxyphenylacetate 3-monooxygenase small component 4639825 hpaC 7125473 hpaC Escherichia coli IAI1 4-hydroxyphenylacetate 3-monooxygenase small component YP_002389794.1 4639313 R 585034 CDS YP_002389795.1 218556881 7125298 complement(4639843..4641405) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8077235, 8550403, 10653707; Product type e : enzyme; 4-hydroxyphenylacetate 3-monooxygenase large component 4641405 hpaB 7125298 hpaB Escherichia coli IAI1 4-hydroxyphenylacetate 3-monooxygenase large component YP_002389795.1 4639843 R 585034 CDS YP_002389796.1 218556882 7125297 complement(4641656..4642546) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8077235, 8550403; Product type r : regulator; Regulator of the 4HPA-hydroxylase operon 4642546 hpaA 7125297 hpaA Escherichia coli IAI1 Regulator of the 4HPA-hydroxylase operon YP_002389796.1 4641656 R 585034 CDS YP_002389797.1 218556883 7125296 complement(4642556..4643992) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8550403, 14744977; Product type pt : putative transporter; putative 4-hydroxyphenylacetate permease hpaX 4643992 7125296 ECIAI1_4569 Escherichia coli IAI1 putative 4-hydroxyphenylacetate permease hpaX YP_002389797.1 4642556 R 585034 CDS YP_002389798.1 218556884 7125474 complement(4644107..4645036) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8529896, 8550403; Product type e : enzyme; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase 4645036 hpaI 7125474 hpaI Escherichia coli IAI1 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase YP_002389798.1 4644107 R 585034 CDS YP_002389799.1 218556885 7125304 complement(4644906..4645811) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8550403, 9492273; Product type e : enzyme; 2-oxo-hepta-3-ene-1,7-dioic acid hydratase 4645811 hpaH 7125304 hpaH Escherichia coli IAI1 2-oxo-hepta-3-ene-1,7-dioic acid hydratase YP_002389799.1 4644906 R 585034 CDS YP_002389800.1 218556886 7125303 complement(4645820..4646200) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2194841; Product type e : enzyme; 5-carboxymethyl-2-hydroxymuconate delta-isomerase 4646200 hpaF 7125303 hpaF Escherichia coli IAI1 5-carboxymethyl-2-hydroxymuconate delta-isomerase YP_002389800.1 4645820 R 585034 CDS YP_002389801.1 218556887 7125301 complement(4646210..4647061) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8550403; Product type e : enzyme; 3,4-dihydroxyphenylacetate 2,3-dioxygenase 4647061 hpaD 7125301 hpaD Escherichia coli IAI1 3,4-dihydroxyphenylacetate 2,3-dioxygenase YP_002389801.1 4646210 R 585034 CDS YP_002389802.1 218556888 7125299 complement(4647063..4648529) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7737515, 2061311, 8550403; Product type e : enzyme; 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase 4648529 hpaE 7125299 hpaE Escherichia coli IAI1 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase YP_002389802.1 4647063 R 585034 CDS YP_002389803.1 218556889 7125300 complement(4648526..4649821) 1 NC_011741.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8223600, 8384293, 11863436; Product type e : enzyme; 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase 4649821 hpaG 7125300 hpaG Escherichia coli IAI1 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase YP_002389803.1 4648526 R 585034 CDS YP_002389804.1 218556890 7125302 4650006..4650533 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8384293, 8550403; Product type r : regulator; 4-hydroxyphenylacetate degradative operon repressor 4650533 hpaR 7125302 hpaR Escherichia coli IAI1 4-hydroxyphenylacetate degradative operon repressor YP_002389804.1 4650006 D 585034 CDS YP_002389805.1 218556891 7125305 4650652..4652316 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20015410, 89034150, 91317710, 10466731, 2033064, 6213619, 6402709, 8384293; Product type r : regulator; methyl-accepting chemotaxis protein I, serine sensor receptor 4652316 tsr 7125305 tsr Escherichia coli IAI1 methyl-accepting chemotaxis protein I, serine sensor receptor YP_002389805.1 4650652 D 585034 CDS YP_002389806.1 218556892 7127511 complement(4652365..4653726) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4653726 yjiZ 7127511 yjiZ Escherichia coli IAI1 putative transporter YP_002389806.1 4652365 R 585034 CDS YP_002389807.1 218556893 7126630 complement(4653941..4654855) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4654855 yjjM 7126630 yjjM Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002389807.1 4653941 R 585034 CDS YP_002389808.1 218556894 7126635 4654994..4656016 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 4656016 yjjN 7126635 yjjN Escherichia coli IAI1 putative oxidoreductase YP_002389808.1 4654994 D 585034 CDS YP_002389809.1 218556895 7126636 complement(4656156..4658447) 1 NC_011741.1 catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I 4658447 mdoB 7126636 mdoB Escherichia coli IAI1 phosphoglycerol transferase I YP_002389809.1 4656156 R 585034 CDS YP_002389810.1 218556896 7127683 complement(4658701..4659195) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4659195 yjjA 7127683 yjjA Escherichia coli IAI1 hypothetical protein YP_002389810.1 4658701 R 585034 CDS YP_002389811.1 218556897 7126631 complement(4659244..4659981) 1 NC_011741.1 acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC 4659981 dnaC 7126631 dnaC Escherichia coli IAI1 DNA replication protein DnaC YP_002389811.1 4659244 R 585034 CDS YP_002389812.1 218556898 7124606 complement(4659984..4660523) 1 NC_011741.1 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI 4660523 dnaT 7124606 dnaT Escherichia coli IAI1 primosomal protein DnaI YP_002389812.1 4659984 R 585034 CDS YP_002389813.2 229598865 7124613 complement(4660631..4661104) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4661104 7124613 ECIAI1_4585 Escherichia coli IAI1 hypothetical protein YP_002389813.2 4660631 R 585034 CDS YP_002389814.1 218556900 7125475 complement(4661095..4661865) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4661865 yjjP 7125475 yjjP Escherichia coli IAI1 hypothetical protein YP_002389814.1 4661095 R 585034 CDS YP_002389815.1 218556901 7126637 4662484..4663209 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4663209 yjjQ 7126637 yjjQ Escherichia coli IAI1 putative DNA-binding transcriptional regulator YP_002389815.1 4662484 D 585034 CDS YP_002389816.1 218556902 7126638 4663221..4663844 1 NC_011741.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; DNA-binding transcriptional activator BglJ 4663844 bglJ 7126638 bglJ Escherichia coli IAI1 DNA-binding transcriptional activator BglJ YP_002389816.1 4663221 D 585034 CDS YP_002389817.1 218556903 7124405 complement(4663882..4664670) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11931550, 14756576, 3323834, 9990318; Product type c : carrier; ferric iron reductase involved in ferric hydroximate transport 4664670 fhuF 7124405 fhuF Escherichia coli IAI1 ferric iron reductase involved in ferric hydroximate transport YP_002389817.1 4663882 R 585034 CDS YP_002389818.1 218556904 7127103 4664700..4665047 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4665047 7127103 ECIAI1_4590 Escherichia coli IAI1 hypothetical protein YP_002389818.1 4664700 D 585034 CDS YP_002389819.1 218556905 7128029 complement(4665676..4666707) 1 NC_011741.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase 4666707 rsmC 7128029 rsmC Escherichia coli IAI1 16S ribosomal RNA m2G1207 methyltransferase YP_002389819.1 4665676 R 585034 CDS YP_002389820.1 218556906 7128438 4666810..4667223 1 NC_011741.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 4667223 holD 7128438 holD Escherichia coli IAI1 DNA polymerase III subunit psi YP_002389820.1 4666810 D 585034 CDS YP_002389821.1 218556907 7125294 4667192..4667638 1 NC_011741.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 4667638 rimI 7125294 rimI Escherichia coli IAI1 ribosomal-protein-alanine N-acetyltransferase YP_002389821.1 4667192 D 585034 CDS YP_002389822.1 218556908 7125001 4667653..4668330 1 NC_011741.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 4668330 yjjG 7125001 yjjG Escherichia coli IAI1 nucleotidase YP_002389822.1 4667653 D 585034 CDS YP_002389823.1 218556909 7126632 4668421..4670010 1 NC_011741.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 4670010 prfC 7126632 prfC Escherichia coli IAI1 peptide chain release factor 3 YP_002389823.1 4668421 D 585034 CDS YP_002389824.1 218556910 7126146 4670403..4671008 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1317380, 8253679, 9298646, 9600841; Product type cp : cell process; periplasmic protein 4671008 osmY 7126146 osmY Escherichia coli IAI1 periplasmic protein YP_002389824.1 4670403 D 585034 CDS YP_002389825.1 218556911 7125998 4671117..4671296 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4671296 ytjA 7125998 ytjA Escherichia coli IAI1 hypothetical protein YP_002389825.1 4671117 D 585034 CDS YP_002389826.1 218556912 7128120 4671418..4672491 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative esterase 4672491 yjjU 7128120 yjjU Escherichia coli IAI1 putative esterase YP_002389826.1 4671418 D 585034 CDS YP_002389827.1 218556913 7126639 4672488..4673270 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative deoxyribonuclease YjjV 4673270 yjjV 7126639 yjjV Escherichia coli IAI1 putative deoxyribonuclease YjjV YP_002389827.1 4672488 D 585034 CDS YP_002389828.1 218556914 7126640 complement(4673383..4674246) 1 NC_011741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative pyruvate formate lyase activating enzyme 4674246 yjjW 7126640 yjjW Escherichia coli IAI1 putative pyruvate formate lyase activating enzyme YP_002389828.1 4673383 R 585034 CDS YP_002389829.1 218556915 7126641 complement(4674218..4675768) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4675768 yjjI 7126641 yjjI Escherichia coli IAI1 hypothetical protein YP_002389829.1 4674218 R 585034 CDS YP_002389830.1 218556916 7126633 4676026..4676805 1 NC_011741.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 4676805 deoC 7126633 deoC Escherichia coli IAI1 deoxyribose-phosphate aldolase YP_002389830.1 4676026 D 585034 CDS YP_002389831.1 218556917 7124565 4676932..4678254 1 NC_011741.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 4678254 deoA 7124565 deoA Escherichia coli IAI1 thymidine phosphorylase YP_002389831.1 4676932 D 585034 CDS YP_002389832.1 218556918 7124563 4678306..4679529 1 NC_011741.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 4679529 deoB 7124563 deoB Escherichia coli IAI1 phosphopentomutase YP_002389832.1 4678306 D 585034 CDS YP_002389833.1 218556919 7124564 4679609..4680328 1 NC_011741.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 4680328 deoD 7124564 deoD Escherichia coli IAI1 purine nucleoside phosphorylase YP_002389833.1 4679609 D 585034 CDS YP_002389834.1 218556920 7125477 complement(4680784..4681800) 1 NC_011741.1 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; lipoate-protein ligase A 4681800 lplA 7125477 lplA Escherichia coli IAI1 lipoate-protein ligase A YP_002389834.1 4680784 R 585034 CDS YP_002389835.1 218556921 7127618 complement(4681828..4682472) 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2684780; hypothetical protein 4682472 ytjB 7127618 ytjB Escherichia coli IAI1 hypothetical protein YP_002389835.1 4681828 R 585034 CDS YP_002389836.1 218556922 7128121 4682578..4683546 1 NC_011741.1 catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 4683546 serB 7128121 serB Escherichia coli IAI1 phosphoserine phosphatase YP_002389836.1 4682578 D 585034 CDS YP_002389837.1 218556923 7127909 4683595..4684977 1 NC_011741.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 4684977 radA 7127909 radA Escherichia coli IAI1 DNA repair protein RadA YP_002389837.1 4683595 D 585034 CDS YP_002389838.1 218556924 7126586 4684998..4686230 1 NC_011741.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 4686230 nadR 7126586 nadR Escherichia coli IAI1 nicotinamide-nucleotide adenylyltransferase YP_002389838.1 4684998 D 585034 CDS YP_002389839.1 218556925 7124516 4686281..4686430 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4686430 7124516 ECIAI1_4614 Escherichia coli IAI1 hypothetical protein YP_002389839.1 4686281 D 585034 CDS YP_002389840.1 218556926 7125478 complement(4686537..4688204) 1 NC_011741.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein 4688204 yjjK 7125478 yjjK Escherichia coli IAI1 putative ABC transporter ATP-binding protein YP_002389840.1 4686537 R 585034 CDS YP_002389841.1 218556927 7126634 4688415..4690352 1 NC_011741.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 4690352 slt 7126634 slt Escherichia coli IAI1 lytic murein transglycosylase YP_002389841.1 4688415 D 585034 CDS YP_002389842.1 218556928 7127931 4690442..4690768 1 NC_011741.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 4690768 trpR 7127931 trpR Escherichia coli IAI1 Trp operon repressor YP_002389842.1 4690442 D 585034 CDS YP_002389843.1 218556929 7127500 complement(4690882..4691862) 1 NC_011741.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 4691862 7127500 ECIAI1_4618 Escherichia coli IAI1 transposase, IS110 family YP_002389843.1 4690882 R 585034 CDS YP_002389844.1 218556930 7125479 complement(4692132..4692662) 1 NC_011741.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase 4692662 yjjX 7125479 yjjX Escherichia coli IAI1 NTPase YP_002389844.1 4692132 R 585034 CDS YP_002389845.1 218556931 7126642 4692705..4693352 1 NC_011741.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 4693352 ytjC 7126642 ytjC Escherichia coli IAI1 phosphoglycerate mutase YP_002389845.1 4692705 D 585034 CDS YP_002389846.1 218556932 7128122 complement(4693349..4694218) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20264525, 20309711, 93194823, 96405618, 8449900; Product type r : regulator; DNA-binding transcriptional activator 4694218 rob 7128122 rob Escherichia coli IAI1 DNA-binding transcriptional activator YP_002389846.1 4693349 R 585034 CDS YP_002389847.1 218556933 7128613 4694429..4694902 1 NC_011741.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3531171, 8449900; hypothetical protein 4694902 creA 7128613 creA Escherichia coli IAI1 hypothetical protein YP_002389847.1 4694429 D 585034 CDS YP_002389848.1 218556934 7126365 4694915..4695604 1 NC_011741.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 4695604 creB 7126365 creB Escherichia coli IAI1 DNA-binding response regulator CreB YP_002389848.1 4694915 D 585034 CDS YP_002389849.1 218556935 7126366 4695604..4697028 1 NC_011741.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 4697028 creC 7126366 creC Escherichia coli IAI1 sensory histidine kinase CreC YP_002389849.1 4695604 D 585034 CDS YP_002389850.1 218556936 7126367 4697086..4698438 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88216172, 2835585, 2984198, 3531171; Product type m : membrane component; hypothetical protein 4698438 creD 7126367 creD Escherichia coli IAI1 hypothetical protein YP_002389850.1 4697086 D 585034 CDS YP_002389851.1 218556937 7126368 complement(4698498..4699214) 1 NC_011741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15028693, 21167794, 21317451, 91008980, 91358353, 92380937, 9514749, 9632255, 2984198, 7565118, 9298646; Product type r : regulator; two-component response regulator 4699214 arcA 7126368 arcA Escherichia coli IAI1 two-component response regulator YP_002389851.1 4698498 R 585034 CDS YP_002389852.1 218556938 7125784 4699850..4700536 1 NC_011741.1 member of the SPOUT superfamily of methyltransferases; putative RNA methyltransferase 4700536 yjtD 7125784 yjtD Escherichia coli IAI1 putative RNA methyltransferase YP_002389852.1 4699850 D 585034 CDS