-- dump date 20140619_082322 -- class Genbank::CDS -- table cds_note -- id note YP_002385499.1 involved in threonine biosynthesis; controls the expression of the thrLABC operon YP_002385500.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_002385501.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_002385502.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_002385503.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385504.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385505.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002385506.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8332529, 92334977, 11298760, 7592346, 8805555, 9007983, 9298646; Product type e : enzyme YP_002385507.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis YP_002385508.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002385509.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8478327; Product type r : regulator YP_002385510.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385511.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_002385512.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_002385513.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90136075, 92048480, 92048481, 99291074; Product type r : regulator YP_002385514.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH YP_002385515.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC YP_002385516.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385517.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385518.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385519.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385520.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_002385521.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385522.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_002385523.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_002385524.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_002385525.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97332650, 2011499; Product type e : enzyme YP_002385526.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_002385527.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides YP_002385528.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_002385529.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_002385530.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_002385531.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7815937, 6308632 YP_002385532.1 regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons YP_002385533.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities YP_002385534.2 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA YP_002385535.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15731894, 97189569, 7815937; Product type e : enzyme YP_002385536.1 catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine YP_002385537.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA YP_002385538.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism YP_002385539.1 required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase YP_002385540.1 involved in electron transfer during carnitine metabolism YP_002385541.1 FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction YP_002385542.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96066354, 12081978; Product type pc : putative carrier YP_002385543.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002385544.1 Required for full activity of KefC, a potassium-proton antiporter YP_002385545.1 transport system that facilitates potassium-efflux YP_002385546.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate YP_002385547.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_002385548.1 protein associated with Co2+ and Mg2+ efflux YP_002385549.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_002385550.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_002385551.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB YP_002385552.1 determines N-hexane tolerance and is involved in outer membrane permeability YP_002385553.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system YP_002385554.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs YP_002385555.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA YP_002385556.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C YP_002385557.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_002385558.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism YP_002385559.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate YP_002385560.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose YP_002385561.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002385562.1 with TbpA and ThiP is part of the thiamine and TPP transport system YP_002385563.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine YP_002385564.1 part of the thiamine and TPP transport system tbpA-thiPQ YP_002385565.1 activates sgrS under glucose-phosphate stress conditions YP_002385566.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385567.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438463, 10209755; Product type t : transporter YP_002385568.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_002385569.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_002385570.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_002385571.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_002385572.1 involved in attenuation control of the leuABCD operon in leucine biosynthesis YP_002385573.1 activator for leuABCD operon; member of LysR family of transcriptional activators YP_002385574.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive YP_002385575.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_002385576.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism YP_002385577.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_002385578.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20042184, 10493123, 2187182, 6350821; Product type e : enzyme YP_002385579.1 membrane bound cell division protein at septum containing leucine zipper motif YP_002385580.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91072213, 92202178, 94095121, 9603865, 9614966, 1332942, 1447153, 2198024, 2677607, 2681146, 3049550, 3911028, 6350821; Product type e : enzyme YP_002385581.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_002385582.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88273095, 90248455, 91310568, 97128642, 11090285, 2668880, 9166795; Product type e : enzyme YP_002385583.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_002385584.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_002385585.1 integral membrane protein involved in stabilizing FstZ ring during cell division YP_002385586.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_002385587.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_002385588.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_002385589.1 involved in septum formation YP_002385590.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane YP_002385591.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_002385592.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_002385593.1 secM translational pause allows for the initiation of secA translation YP_002385594.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_002385595.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10218109, 89264540, 90136514, 91225007, 97444511, 1309939, 2841285, 3033442, 3288626, 7578113, 9063868; Product type e : enzyme YP_002385596.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385597.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_002385598.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate YP_002385599.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96099298, 2904262, 7959070; Product type s : structure YP_002385600.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96099298, 7959070; Product type pt : putative transporter YP_002385601.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20100782, 20271862, 96099298, 7959070; Product type ps : putative structure YP_002385602.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide YP_002385603.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90113890, 95047240, 2607970, 7959070; Product type e : enzyme YP_002385604.1 involved in regulation of beta-lactamase; putative signaling protein YP_002385605.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1104763, 90174991, 9150230; Product type t : transporter YP_002385606.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex YP_002385607.1 Evidence 6 : Doubtful CDS YP_002385608.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_002385609.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains YP_002385610.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_002385611.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385612.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_002385613.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2666401, 7567469 YP_002385614.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine YP_002385615.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_002385616.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2666401 YP_002385617.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification YP_002385618.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10359647, 11604400, 14612441, 91035240, 93123180, 93286127; Product type e : enzyme YP_002385619.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 13808016, 339828, 6787390, 6801015, 12070315; Product type e : enzyme YP_002385620.1 catalyzes the interconversion of bicarbonate and carbon dioxide YP_002385621.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002385622.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10474187; Product type pt : putative transporter YP_002385623.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002385624.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385625.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_002385626.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11319082; Product type pe : putative enzyme YP_002385627.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_002385628.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_002385629.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8096212; Product type ps : putative structure YP_002385630.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002385631.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002385632.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002385633.1 similar to the fimbrial usher protein PapC YP_002385634.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 93352405, 8102362, 15561151; Product type f : factor YP_002385635.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002385636.1 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP YP_002385637.1 Polymerase that creates the 3' poly(A) tail found in some mRNA's YP_002385638.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu YP_002385639.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15294157, 90202727, 2013578, 9298646, 9600841; Product type r : regulator YP_002385640.1 Regulatory factor involved in maltose metabolism YP_002385641.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97094878; Product type e : enzyme YP_002385642.1 similar in sequence to the ATP-dependent RNA helicase HrpA YP_002385643.1 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell YP_002385644.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein YP_002385645.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter YP_002385646.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores YP_002385647.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome YP_002385648.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_002385649.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation YP_002385650.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors YP_002385651.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002385652.1 solute binding component of the vitamin B12 transport system BtuCDF YP_002385653.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_002385654.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate YP_002385655.1 protease Do; required at high temperature; degrades damaged proteins YP_002385656.1 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization YP_002385657.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385658.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_002385659.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein YP_002385660.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_002385661.1 Evidence 6 : Doubtful CDS YP_002385662.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_002385663.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_002385664.1 Catalyzes the phosphorylation of UMP to UDP YP_002385665.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_002385666.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_002385667.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_002385669.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate YP_002385670.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response YP_002385671.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins YP_002385672.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15101556, 90201355, 97032152, 99386928, 1987124, 2843433, 9298646, 2167239; Product type f : factor YP_002385673.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_002385674.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_002385675.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_002385676.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_002385677.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_002385678.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_002385679.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_002385680.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97480927, 98195734, 98357244, 9226257, 9723924; Product type e : enzyme YP_002385681.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385682.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase YP_002385683.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination YP_002385684.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385685.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385686.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385687.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11830644, 95362641, 95362642; Product type lp : lipoprotein YP_002385688.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_002385689.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385690.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 93094132; Product type pr : putative regulator YP_002385691.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12169620, 12218041, 12819857, 1459951; Product type t : transporter YP_002385692.1 part of the MetNIQ methionine uptake system YP_002385693.1 part of the metNIQ transport system for methionine YP_002385694.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate YP_002385695.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid YP_002385696.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002385697.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1663890 YP_002385698.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385699.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall YP_002385700.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione YP_002385701.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385702.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_002385703.1 3'-5' exonuclease of DNA polymerase III YP_002385704.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385705.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15919996; Product type m : membrane component YP_002385706.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385707.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385708.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme YP_002385709.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385710.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385711.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor YP_002385712.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002385713.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385714.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385715.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385716.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385717.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385718.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385719.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385720.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385721.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385722.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385723.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385724.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385725.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002385726.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385727.1 Evidence 5 : No homology to any previously reported sequences YP_002385728.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype YP_002385729.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9696756 YP_002385730.1 Evidence 6 : Doubtful CDS YP_002385731.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9696756; Product type h : extrachromosomal origin YP_002385732.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385734.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7868617, 8387990 YP_002385735.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7868617, 8387990 YP_002385736.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype YP_002385737.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8526497; Product type pe : putative enzyme YP_002385738.1 inactivates vertebrate C-type lysozyme YP_002385739.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA YP_002385740.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate YP_002385741.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385742.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385743.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15009896; Product type f : factor YP_002385744.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99451883; Product type pf : putative factor YP_002385745.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385746.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385747.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385748.1 Evidence 7 : Gene remnant; Product type s : structure YP_002385749.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15687208; Product type s : structure YP_002385750.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_002385751.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12813093; Product type pe : putative enzyme YP_002385752.1 mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY YP_002385753.1 similar to release factor 1 and 2 YP_002385754.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1695895, 21101837, 88121730, 92204123, 2651887; Product type e : enzyme YP_002385755.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively YP_002385756.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation YP_002385757.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS YP_002385758.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89178658, 89380253, 92219258, 98090453, 1380671, 1848301, 1848682, 6089111, 6341601, 7679770; Product type t : transporter YP_002385759.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_002385760.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_002385761.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002385762.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385763.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385764.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385765.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385766.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002385767.1 Evidence 6 : Doubtful CDS YP_002385768.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385769.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002385770.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385771.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385772.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 17563352, 11466275; Product type s : structure YP_002385773.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002385774.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_002385775.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor YP_002385776.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002385777.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002385778.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385779.1 Involved in disulfide oxidoreductase activity and electron transport YP_002385780.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002385781.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385782.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385783.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385784.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385785.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002385786.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine YP_002385787.1 catalyzes the formation of betaine from betaine aldehyde YP_002385788.1 HTH-type; bet1; Repressor involved in choline regulation of the bet genes YP_002385789.1 proton-motive-force-driven choline transporter YP_002385790.1 Evidence 2b : Function of strongly homologous gene; Product type pm : putative membrane component YP_002385791.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15995192; Product type e : enzyme YP_002385792.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002385793.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002385794.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385795.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385796.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385797.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385798.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7711027, 11523892; Product type pe : putative enzyme YP_002385799.1 metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain YP_002385800.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385801.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002385802.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385803.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002385804.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002385805.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385806.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385807.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385808.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12879215; Product type t : transporter YP_002385809.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385810.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9325432, 15805526; Product type r : regulator YP_002385811.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate YP_002385812.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity YP_002385813.1 functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C YP_002385814.1 catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent YP_002385815.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme YP_002385816.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92349961; Product type t : transporter YP_002385817.1 Catalyzes the deamination of cytosine to uracil and ammonia YP_002385818.1 controls the expression of the cynTSX operon involved in degrading and using cyanate as a sole nitrogen source YP_002385819.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91242169, 92156106, 94075239, 3049588; Product type e : enzyme YP_002385820.1 catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide YP_002385821.1 MFS transporter family member induced in the presence of cyanate as part of a 3 gene operon; not essential YP_002385822.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments YP_002385823.1 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon YP_002385824.1 transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer YP_002385825.1 activator of 3-phenylpropionic acid catabolism YP_002385826.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate YP_002385827.1 catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family YP_002385828.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87008429, 94002258, 15663942; Product type e : enzyme YP_002385829.1 catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid YP_002385830.1 catalyzes the formation of acetyl-CoA from acetalaldehyde YP_002385831.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate YP_002385832.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7961399; Product type t : transporter YP_002385833.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15115803, 12878731, 13129938; Product type e : enzyme YP_002385834.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16567800, 15466022; Product type e : enzyme YP_002385835.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15466022, 87172301, 1731906; Product type e : enzyme YP_002385836.1 formaldehyde-induced negative regulator of the frmRAB operon YP_002385837.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385838.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385839.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385840.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385841.1 with TauB and TauC is responsible for taurine uptake. YP_002385842.1 Part of the ABC transporter complex tauABC involved in taurine import YP_002385843.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9401024, 96404792; Product type t : transporter YP_002385844.1 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers YP_002385845.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_002385846.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002385847.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385848.1 this protein has no known enzymatic function YP_002385849.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385850.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope YP_002385851.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002385852.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002385853.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385854.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_002385855.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385856.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1718819, 7737514; Product type pe : putative enzyme YP_002385857.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15126494, 7737514; Product type pe : putative enzyme YP_002385858.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385859.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme YP_002385860.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3533724, 2160940; Product type f : factor YP_002385861.1 catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis YP_002385862.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_002385863.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385864.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_002385865.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385866.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 86085675, 3001025 YP_002385867.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385868.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385869.1 Required for efficient pilin antigenic variation YP_002385870.1 catalyzes phosphorylation of fructose; cytosolic enzyme YP_002385871.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers YP_002385872.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity YP_002385873.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity YP_002385874.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB YP_002385875.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB YP_002385876.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385877.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3078876, 6998958, 3550103, 7984428; Product type t : transporter YP_002385878.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation YP_002385879.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92184757, 1706703, 1918057; Product type e : enzyme YP_002385880.1 Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP YP_002385881.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_002385882.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_002385883.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_002385884.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_002385885.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_002385886.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385887.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91092502, 91358319, 93352541; Product type m : membrane component YP_002385888.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein YP_002385889.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator YP_002385890.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil YP_002385891.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_002385892.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_002385893.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP YP_002385894.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate YP_002385895.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217, 16077126; Product type e : enzyme YP_002385896.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_002385897.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89291702, 91210228; Product type e : enzyme YP_002385898.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_002385899.1 Required for the synthesis of the thiazole moiety YP_002385900.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 97039868, 99173753, 99311269 YP_002385901.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis YP_002385902.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_002385903.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002385904.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385905.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385906.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385907.1 converts protoheme IX and farnesyl diphosphate to heme O YP_002385908.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 90366572, 92345252, 9378722, 98021084, 11017202, 2162835; Product type c : carrier YP_002385909.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 92345252, 93349845, 9378722, 98021084, 11017202, 2162835, 2168206; Product type c : carrier YP_002385910.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 92345252, 93349845, 9378722, 98021084, 11017202, 2162835, 2168206; Product type c : carrier YP_002385911.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92112945, 92371427, 9378722, 98021084, 11017202, 1322173, 2162835, 2162837, 2165491, 2168206, 8231804, 8618822; Product type c : carrier YP_002385912.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein YP_002385913.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein YP_002385914.1 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress YP_002385915.1 Evidence 6 : Doubtful CDS YP_002385916.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_002385917.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_002385918.1 binds and unfolds substrates as part of the ClpXP protease YP_002385919.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10094703, 14665623, 8939438, 91072263, 97137085, 2984174, 3042779, 3289547, 7988699, 8226758, 8294008; Product type e : enzyme YP_002385920.1 histone-like DNA-binding protein YP_002385921.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9670013; Product type e : enzyme YP_002385922.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385923.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385924.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His YP_002385925.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385926.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217; Product type e : enzyme YP_002385927.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002385928.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 94124004, 10850996; Product type pt : putative transporter YP_002385929.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 94124004; Product type pt : putative transporter YP_002385930.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia. YP_002385931.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22020597, 9618533, 10931328, 1645722, 7984428; Product type t : transporter YP_002385932.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86139906, 91250410, 10876240; Product type e : enzyme YP_002385933.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002385934.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385935.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385936.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002385937.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002385938.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82180540, 91310703, 9600841; Product type e : enzyme YP_002385939.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins YP_002385940.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1956303, 7984428, 14645275 YP_002385941.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12351840, 12654283, 15111118, 15155734, 21450803, 94012493, 10920254, 7651136; Product type t : transporter YP_002385942.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15155734, 21450803, 383699, 390095, 94012493, 10920254, 7651136; Product type t : transporter YP_002385943.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine YP_002385944.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS YP_002385945.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385946.1 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks YP_002385947.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002385948.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_002385949.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_002385950.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15322138, 1698765, 2674903 YP_002385951.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_002385952.1 molecular chaperone YP_002385953.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_002385954.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_002385955.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9401025, 98244813, 2051480, 7721718; Product type e : enzyme YP_002385956.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90155203, 95238302, 2051480; Product type e : enzyme YP_002385957.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein YP_002385958.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 97074653, 8917080; Product type t : transporter YP_002385959.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides YP_002385960.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385961.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385962.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002385963.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12351646, 20105527, 11167016, 11500054, 9868784; Product type t : transporter YP_002385964.1 catalyzes the formation of glutamate from glutamine YP_002385965.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002385966.1 activator of copper-responsive regulon genes YP_002385967.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002385968.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385969.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002385970.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002385971.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002385972.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002385973.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91270121, 91324311, 93163029, 93252782, 94179121, 99353977, 1864840, 8432696, 8098033; Product type e : enzyme YP_002385974.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002385975.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type t : transporter YP_002385976.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 98361897, 1766878, 2403547, 2644231, 7934896; Product type h : extrachromosomal origin YP_002385977.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385978.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1766878, 7934896; Product type h : extrachromosomal origin YP_002385979.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385980.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002385981.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA YP_002385982.1 activator of the allDC-ylbA operon involved in allantoin utilization YP_002385983.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate YP_002385984.1 regulates operons involved in the utilization of allantoin YP_002385985.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate YP_002385986.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20029625, 8440684; Product type e : enzyme YP_002385987.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20069628; Product type e : enzyme YP_002385988.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1293888; Product type t : transporter YP_002385989.1 Plays a crucial role on both purine and pyrimidine metabolism YP_002385990.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002385991.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20069628; Product type e : enzyme YP_002385992.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385993.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_002385994.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12460564, 20069628, 69151449; Product type e : enzyme YP_002385995.1 multicopy suppressor of dominant negative ftsH mutations YP_002385996.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385997.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002385998.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2464576, 2644189, 7920643, 7940673, 7984428; Product type pe : putative enzyme YP_002385999.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_002386000.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10074353, 8117684, 89123018, 89123019, 92287929, 10574791; Product type e : enzyme YP_002386001.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine YP_002386002.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90272647, 91175755, 1606970, 1864365, 8601841, 9298646, 9600841; Product type e : enzyme YP_002386003.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_002386004.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386005.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12837795, 1748668, 7567469; Product type pr : putative regulator YP_002386006.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_002386007.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2890624; Product type ps : putative structure YP_002386008.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15372038, 2553674; Product type f : factor YP_002386009.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1970114; Product type pf : putative factor YP_002386010.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002386011.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2890624; Product type ps : putative structure YP_002386012.1 activates the production of the major fimbrae protein FimA YP_002386013.1 Evidence 6 : Doubtful CDS YP_002386014.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6317653, 2536924; Product type r : regulator YP_002386015.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386016.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89359086, 94042873, 94042874; Product type m : membrane component YP_002386017.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89359086, 94042873, 94042874; Product type m : membrane component YP_002386018.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype YP_002386019.1 Evidence 6 : Doubtful CDS YP_002386020.1 Evidence 6 : Doubtful CDS YP_002386021.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1766878, 2644231, 2403547, 7934896 YP_002386022.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386023.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9696756, 8557353 YP_002386024.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 11283292, 11399769; Product type r : regulator YP_002386025.1 response regulator in two-component regulatory system with CusS; regulates the copper efflux system YP_002386026.1 with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver YP_002386027.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 21125583, 11283292, 11399769, 12813074; Product type f : factor YP_002386028.1 with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver YP_002386029.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 21125583, 21178899, 21450803, 11399769, 12813074, 1711024, 7984428; Product type t : transporter YP_002386030.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91267923, 94042931, 8626334; Product type t : transporter YP_002386031.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386032.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive YP_002386033.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386034.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386035.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity YP_002386036.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99291074; Product type f : factor YP_002386037.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10361310; Product type pm : putative membrane component YP_002386038.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89313305, 90132534, 91035252, 8939709, 9214294; Product type e : enzyme YP_002386039.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space YP_002386040.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92291125, 94198561, 2974033; Product type e : enzyme YP_002386041.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386042.1 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin YP_002386043.1 part of the ferric enterobactin transport system; necessary for enetrobactin uptake YP_002386044.1 with FepBDE is involved in the transport of ferric enterobactin YP_002386045.1 with FepBCD is involved in the transport of ferric enterobactin YP_002386046.1 with FepBCG is involved in the transport of ferric enterobactin YP_002386047.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters YP_002386048.1 with FepCDG is involved in the transport of ferric enterobactin YP_002386049.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89123153, 90165423, 90241936, 2110093, 2139473; Product type e : enzyme YP_002386050.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate YP_002386051.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20183918, 90241937, 91035252, 9485415, 97361959, 2521621, 2521622; Product type e : enzyme YP_002386052.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin YP_002386053.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2521621, 2521622, 15808744; Product type pe : putative enzyme YP_002386054.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91162636, 2521622; Product type pf : putative factor YP_002386055.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386056.1 member of the iron-containing alcohol dehydrogenase family; unknown function YP_002386057.1 catalyzes the transfer of an amino moiety YP_002386058.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12057959; Product type r : regulator YP_002386059.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12057959; Product type r : regulator YP_002386060.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002386061.1 Involved in disulfide bond formation YP_002386062.1 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate YP_002386063.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89197774, 1592833; Product type e : enzyme YP_002386064.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 12071968; Product type f : factor YP_002386065.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8185833; Product type pe : putative enzyme YP_002386066.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation YP_002386067.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90151658, 90264307, 2253883, 8188249; Product type e : enzyme YP_002386068.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9696764; Product type t : transporter YP_002386069.1 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA YP_002386070.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate YP_002386071.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme YP_002386072.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme YP_002386073.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate YP_002386074.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme YP_002386075.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11889485, 21885746, 9701802; Product type r : regulator YP_002386076.1 regulates the expression of citAB in citrate fermentation YP_002386077.1 responsible for the transport of C4-dicarboxylates during anaerobic growth YP_002386078.1 catalyzes the transfer of palmitate to lipid A YP_002386079.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator YP_002386080.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_002386081.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386082.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_002386083.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_002386084.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12218038; Product type pr : putative regulator YP_002386085.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_002386086.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8444795 YP_002386087.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors YP_002386088.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88058785, 2644207; Product type lp : lipoprotein YP_002386089.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89123070, 90036736, 91072213, 3316191; Product type cp : cell process YP_002386090.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86196149, 87030266, 89174517, 2644207; Product type e : enzyme YP_002386091.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_002386092.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386093.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7929373; Product type pe : putative enzyme YP_002386094.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_002386095.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_002386096.1 rare lipoprotein B; involved in the assembly of LPS in the outer membrane YP_002386097.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_002386098.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11373298, 12105207, 3320963, 7567469 YP_002386099.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386100.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386101.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12183460, 10574456; Product type pf : putative factor YP_002386102.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386103.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386104.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12183460, 12054669; Product type f : factor YP_002386105.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12183460, 14734171, 22055095, 9735342; Product type f : factor YP_002386106.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific YP_002386107.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter YP_002386108.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter YP_002386109.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter YP_002386110.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1091636, 1091635, 10493123, 8740179, 10972807; Product type t : transporter YP_002386111.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386112.1 Transfers the fatty acyl group on membrane lipoproteins YP_002386113.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1779764; Product type pt : putative transporter YP_002386114.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16511207; Product type pe : putative enzyme YP_002386115.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12762842; Product type pe : putative enzyme YP_002386116.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_002386117.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q YP_002386120.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP YP_002386121.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16430214, 89343637; Product type e : enzyme YP_002386122.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15066032, 90136533, 91171292, 92114782, 92356048, 2190615, 2668691, 7545108; Product type r : regulator YP_002386123.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate YP_002386124.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate YP_002386125.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002386126.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002386127.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2118530, 9636669; Product type pt : putative transporter YP_002386128.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein YP_002386129.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer YP_002386130.1 Evidence 6 : Doubtful CDS YP_002386131.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_002386132.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20223640, 12427949; Product type cp : cell process YP_002386133.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme YP_002386134.1 negative modulator of the initiation of chromosome replication YP_002386135.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate YP_002386136.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system YP_002386137.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92041955; Product type e : enzyme YP_002386138.1 response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport YP_002386139.1 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein YP_002386140.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex YP_002386141.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_002386142.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_002386143.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386144.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 98361897, 2403547, 2644231, 7934896, 8387990; Product type h : extrachromosomal origin YP_002386145.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002386146.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386147.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6325460, 8387990 YP_002386148.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent YP_002386149.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15175316; Product type pt : putative transporter YP_002386150.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14519207 YP_002386151.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386152.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386153.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1729609; Product type pe : putative enzyme YP_002386154.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity YP_002386155.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8002588; Product type ph : phenotype YP_002386156.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386157.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10049807; Product type pf : putative factor YP_002386158.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386159.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor YP_002386160.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH YP_002386161.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6237244, 89076355, 89123360, 9521736, 99414342, 11259408, 3309132, 6383359, 9822661; Product type m : membrane component YP_002386162.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82124790, 89076355, 9521736, 99414342, 6383359; Product type m : membrane component YP_002386163.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_002386164.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_002386165.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_002386166.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_002386167.1 catalyzes the interconversion of succinyl-CoA and succinate YP_002386168.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_002386169.1 regulates the succiny-lCoA synthetase operon YP_002386170.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_002386171.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14645248, 9063979; Product type e : enzyme YP_002386172.1 Evidence 6 : Doubtful CDS YP_002386173.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87299685, 89255232, 91035243, 1689724, 1724280, 2843510, 3138232; Product type c : carrier YP_002386174.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87299685, 89255232, 91035243, 2843510, 3138232; Product type c : carrier YP_002386175.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386176.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components YP_002386177.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_002386178.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_002386179.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins YP_002386180.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_002386181.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11790745, 87133578, 92244043, 99403391, 11173492, 2687247; Product type lp : lipoprotein YP_002386182.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity YP_002386183.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_002386184.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 219824, 90330519; Product type t : transporter YP_002386185.1 involved in zinc efflux across the cytoplasmic membrane YP_002386186.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386187.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_002386188.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_002386189.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose YP_002386190.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism YP_002386191.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P YP_002386192.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89274199, 92253563, 92338916, 3022232, 6301942, 8564363, 8611559, 8931134, 9174344, 9271499, 9708982; Product type e : enzyme YP_002386193.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum YP_002386194.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons YP_002386195.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386196.1 with ModCB is involved in the high-affinity transport of molybdate YP_002386197.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE YP_002386198.1 Part of the ABC transporter complex modABC involved in molybdenum import YP_002386199.1 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily YP_002386200.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate YP_002386201.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002386203.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386204.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386205.1 Evidence 6 : Doubtful CDS YP_002386206.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11782506; Product type pe : putative enzyme YP_002386207.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family YP_002386208.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6446713; Product type h : extrachromosomal origin YP_002386209.1 Evidence 6 : Doubtful CDS YP_002386210.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1718819, 7737514; Product type pe : putative enzyme YP_002386211.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15126494, 7737514; Product type pe : putative enzyme YP_002386213.1 Evidence 6 : Doubtful CDS YP_002386214.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386215.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386216.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386217.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002386218.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002386219.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002386220.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 6458018, 6221115; Product type h : extrachromosomal origin YP_002386221.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002386222.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002386223.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386224.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386225.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002386226.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002386227.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 612476; Product type h : extrachromosomal origin YP_002386228.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2995831; Product type h : extrachromosomal origin YP_002386229.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002386233.1 DLP12 prophage YP_002386234.1 DLP12 prophage; conserved protein similar to phage 82 and lambda proteins YP_002386235.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002386236.1 DLP12 prophage; Holliday junction resolvase YP_002386237.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8648624, 9278503; Product type pf : putative factor YP_002386238.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 3017988, 8057841; Product type m : membrane component YP_002386239.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019562; Product type pe : putative enzyme YP_002386240.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3017988; Product type pe : putative enzyme YP_002386241.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019562; Product type pe : putative enzyme YP_002386242.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 95173101; Product type pm : putative membrane component YP_002386243.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92334985; Product type h : extrachromosomal origin YP_002386244.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin YP_002386245.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11302702; Product type h : extrachromosomal origin YP_002386246.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin YP_002386247.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin YP_002386248.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin YP_002386249.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin YP_002386250.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin YP_002386251.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin YP_002386252.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002386253.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002386254.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002386255.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002386256.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002386257.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002386259.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002386260.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002386261.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002386262.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002386263.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002386264.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002386269.1 YbhB; similar to rat and human kinase inhibitory proteins YP_002386270.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate YP_002386271.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11834738, 12475249, 14704425, 14967041, 20250955, 89066784, 94170810, 94190882, 97382445, 11686925; Product type e : enzyme YP_002386272.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine YP_002386273.1 putative methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth YP_002386274.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_002386275.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_002386276.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16272399; Product type pe : putative enzyme YP_002386277.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_002386278.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93368423; Product type pf : putative factor YP_002386279.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_002386280.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin YP_002386281.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin YP_002386282.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386283.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002386284.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386285.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386286.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20102623, 10634942; Product type e : enzyme YP_002386287.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386288.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386289.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386290.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386291.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386292.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16092522; Product type pt : putative transporter YP_002386293.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002386294.1 this helicase is not essential cell growth YP_002386295.1 Evidence 5 : No homology to any previously reported sequences YP_002386296.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme YP_002386297.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386298.1 helicase involved in DNA repair and perhaps also replication YP_002386299.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386300.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8405966; Product type pe : putative enzyme YP_002386301.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386302.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386303.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386304.1 Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein YP_002386305.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386306.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386307.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002386308.1 similar to ATP-binding component of ABC transporters YP_002386309.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine YP_002386310.1 similar to periplasmic-binding component of ABC transporters YP_002386311.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage YP_002386312.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12648727, 8021175; Product type t : transporter YP_002386313.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains YP_002386314.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16514146; Product type pe : putative enzyme YP_002386315.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present YP_002386316.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386317.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10493123, 9298646 YP_002386318.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11916677; Product type pt : putative transporter YP_002386319.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme YP_002386320.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386321.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15657928; Product type e : enzyme YP_002386322.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16218870; Product type pe : putative enzyme YP_002386323.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15581584; Product type pe : putative enzyme YP_002386324.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies YP_002386325.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase YP_002386326.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum YP_002386327.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15159592, 20508248, 3045084, 7984428; Product type e : enzyme YP_002386328.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains YP_002386329.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17366475; Product type pt : putative transporter YP_002386330.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386331.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386332.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386333.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type pe : putative enzyme YP_002386334.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit YP_002386335.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing YP_002386336.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16522795, 16864586; Product type e : enzyme YP_002386337.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386338.1 penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_002386339.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89231635, 89336786, 92231401, 2994018; Product type r : regulator YP_002386340.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15778224; Product type e : enzyme YP_002386341.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10022825, 12578981, 14688269, 21217867, 21450803, 9079913, 9644262, 99030337, 8655497; Product type t : transporter YP_002386342.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386343.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme YP_002386344.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386345.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002386346.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386347.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386348.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase YP_002386349.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function YP_002386350.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds YP_002386351.1 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 YP_002386352.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386353.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992, 9651355, 9298646, 8416922; Product type t : transporter YP_002386354.1 part of the PotFGHI ATP-dependent putrescine transporter YP_002386355.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992; Product type t : transporter YP_002386356.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992; Product type t : transporter YP_002386357.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386358.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA YP_002386359.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93273744, 9298646, 9600841, 8801422; Product type t : transporter YP_002386360.1 with ArtPQJI acts to transport arginine across the inner membrane YP_002386361.1 with ArtPMJI transports arginine across the inner membrane YP_002386362.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93273744, 9298646, 9600841, 8801422, 9740056; Product type t : transporter YP_002386363.1 With ArtMQJI transports arginine across the inner membrane YP_002386364.1 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS YP_002386365.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386366.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386367.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386368.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386369.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine YP_002386370.1 catalyzes the formation of acetate from pyruvate YP_002386371.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20117674; Product type e : enzyme YP_002386372.1 catalyzes the reduction of hydroxylamine to ammonia and water YP_002386373.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386374.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure YP_002386375.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386376.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386377.1 confers macrolide resistance via active drug efflux YP_002386378.1 with MacA is involved in the export of macrolide YP_002386379.1 inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible YP_002386380.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_002386381.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates YP_002386382.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386383.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_002386384.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_002386385.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_002386386.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_002386387.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding YP_002386388.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system YP_002386389.1 DNA-binding membrane protein required for chromosome resolution and partitioning YP_002386390.1 participates with LolB in the incorporation of lipoprotein into the outer membrane YP_002386391.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7567469, 7628437, 11459952, 11029431; Product type cp : cell process YP_002386392.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002386393.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91008971, 92011349, 94171715, 10801884, 3062312; Product type e : enzyme YP_002386394.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91070067, 91355180, 92011349, 3062312; Product type e : enzyme YP_002386395.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91008971, 92011349, 3062312, 8429002; Product type e : enzyme YP_002386396.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9782055, 3062312, 11714269; Product type pe : putative enzyme YP_002386397.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386398.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type pt : putative transporter YP_002386399.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002386400.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3053170; Product type pe : putative enzyme YP_002386401.1 activates pyruvate formate-lyase 1 under anaerobic conditions YP_002386402.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91064082, 92276323, 10504733, 1310545, 2651404, 3053170, 9629924; Product type e : enzyme YP_002386403.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293770, 2651404; Product type t : transporter YP_002386404.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386405.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386406.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_002386407.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_002386408.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor YP_002386410.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_002386411.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_002386412.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_002386413.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386414.1 involved in the transport of lipid A across the inner membrane YP_002386415.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_002386416.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386417.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386418.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_002386419.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386420.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386421.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA YP_002386422.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division YP_002386423.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division YP_002386424.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects YP_002386425.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386426.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386427.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14529289; Product type pe : putative enzyme YP_002386428.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_002386429.1 outer membrane porin F; 1a; Ia; b YP_002386430.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002386431.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate YP_002386432.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101837, 86164315, 87163509, 2436977, 3018440; Product type e : enzyme YP_002386433.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease YP_002386434.1 part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease YP_002386435.1 catalyzes the release of sulfite from alkanesulfonates YP_002386436.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease YP_002386437.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20245523, 99410391, 99436146, 8774726; Product type e : enzyme YP_002386438.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type ps : putative structure YP_002386439.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor YP_002386440.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor YP_002386441.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7721701; Product type ps : putative structure YP_002386442.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002386443.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002386444.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor YP_002386445.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_002386446.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386447.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1327782; Product type pe : putative enzyme YP_002386448.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA YP_002386449.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth YP_002386450.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95270582; Product type cp : cell process YP_002386451.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95270582; Product type cp : cell process YP_002386452.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386453.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1101029, 90207255, 2832401, 8440252; Product type f : factor YP_002386454.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_002386455.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386456.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386457.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d YP_002386458.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10368140, 91072263, 93163041, 98348458, 3297925, 6253901, 6306396; Product type cp : cell process YP_002386459.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386460.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386461.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386462.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand YP_002386463.1 catalyzes the formation of methylglyoxal from glycerone phosphate YP_002386464.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386465.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386466.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12700277, 15569148; Product type f : factor YP_002386467.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386468.1 catalyzes the hydrolysis of acylphosphate YP_002386469.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs YP_002386470.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6376117; Product type m : membrane component YP_002386471.1 Evidence 6 : Doubtful CDS YP_002386472.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86192450, 90202716, 92215587; Product type e : enzyme YP_002386473.1 involved in hydrogen cycling during fermentative growth YP_002386474.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202716, 91310595, 92215587; Product type c : carrier YP_002386475.1 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1) YP_002386476.1 involved in processing hydrogenase proteins HyaA and HyaB YP_002386477.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202716, 91310595, 92215587; Product type f : factor YP_002386478.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92049231, 96198179; Product type c : carrier YP_002386479.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92049231, 96198179; Product type c : carrier YP_002386480.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20122624, 92049231, 93054596, 10696472, 2168385, 3038201, 8387749; Product type e : enzyme YP_002386481.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10369665, 11090276, 2168385, 7984428; Product type e : enzyme YP_002386482.1 Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk YP_002386483.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8759852; Product type pt : putative transporter YP_002386484.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386485.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386486.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002386487.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386488.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9484881, 9439003; Product type f : factor YP_002386489.1 Evidence 6 : Doubtful CDS YP_002386490.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9484881, 15466053, 8631696, 9439003; Product type r : regulator YP_002386491.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor YP_002386492.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15317805, 11544213; Product type pr : putative regulator YP_002386493.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002386494.1 Evidence 6 : Doubtful CDS YP_002386495.1 Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide YP_002386496.1 periplasmic sensory protein associated with the TorRS two-component regulatory system YP_002386497.1 response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes YP_002386498.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293785, 94314186, 99340208, 11056172, 11562502; Product type c : carrier YP_002386499.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88193091, 90089471, 94293785, 8302830, 8022286; Product type e : enzyme YP_002386500.1 TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor YP_002386501.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA YP_002386502.1 functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock YP_002386503.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12455612, 90368616, 91297199, 2153660, 9298646; Product type e : enzyme YP_002386504.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386505.1 stationary phase protein that binds TrpR repressor YP_002386506.1 Evidence 6 : Doubtful CDS YP_002386507.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386508.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type t : transporter YP_002386509.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542, 10633095; Product type e : enzyme YP_002386510.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme YP_002386511.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme YP_002386512.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme YP_002386513.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme YP_002386514.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme YP_002386515.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type r : regulator YP_002386516.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein YP_002386517.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386518.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12923181, 88213396, 91227628, 93132799, 98359785, 1400239, 1567896, 3053649, 3053687, 3302614, 3325781, 8119910; Product type t : transporter YP_002386519.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter YP_002386520.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17627767, 10493123; Product type t : transporter YP_002386521.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17627767, 16551627, 15375152; Product type t : transporter YP_002386522.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8444794, 2160940; Product type pe : putative enzyme YP_002386523.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386524.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11237876, 10493123; Product type e : enzyme YP_002386525.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12661000; Product type pe : putative enzyme YP_002386526.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386527.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386528.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8817489; Product type lp : lipoprotein YP_002386529.1 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex YP_002386530.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex YP_002386531.1 activates the csgBA and csgDEFG operons involved in biofilm formation YP_002386532.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface YP_002386533.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89201357, 93023873, 1677357, 8459772, 8817489, 1357528; Product type s : structure YP_002386534.1 involved in autoagglutination of curliated cells; not involved in production of curli fibers YP_002386535.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386536.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386537.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386538.1 required for the transfer of succinyl residues to the glucan backbone YP_002386539.1 Evidence 6 : Doubtful CDS YP_002386540.1 Evidence 6 : Doubtful CDS YP_002386541.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan YP_002386542.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space YP_002386543.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein YP_002386544.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 92165719 YP_002386545.1 Confers resistance to fosfomycin and deoxycholate YP_002386546.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_002386547.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1840644 YP_002386548.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15741337, 11298273, 1840644, 9298646; Product type c : carrier YP_002386549.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002386550.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386551.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids YP_002386552.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing YP_002386553.2 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11230150, 11152126; Product type f : factor YP_002386554.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_002386555.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein YP_002386556.1 cofactor involved in the reduction of disulfides YP_002386557.1 Confers resistance to norfloxacin and enoxacin YP_002386558.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88121676, 90136529, 1356970; Product type e : enzyme YP_002386559.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1356970, 2828880 YP_002386560.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386561.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386562.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10320579; Product type f : factor YP_002386563.1 regulates the flagellar specific sigma28 transcription factor YP_002386564.1 required for the assembly of the flagellar basal body P-ring YP_002386565.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella YP_002386566.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_002386567.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production YP_002386568.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod YP_002386569.1 makes up the distal portion of the flagellar basal body rod YP_002386570.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod YP_002386571.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_002386572.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space YP_002386573.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_002386574.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes YP_002386575.1 bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase YP_002386576.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA YP_002386577.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_002386578.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 90008815, 1447160 YP_002386579.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_002386580.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_002386581.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_002386582.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92052166, 92183950, 92210530, 92234941, 7700236, 7768883, 9298646; Product type e : enzyme YP_002386583.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002386584.1 carries the fatty acid chain in fatty acid biosynthesis YP_002386585.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_002386586.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate YP_002386587.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002386588.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_002386589.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_002386590.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8505303, 8509334, 10747959; Product type pe : putative enzyme YP_002386591.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002386592.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90286919, 3032906, 10529396; Product type t : transporter YP_002386593.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15703176, 10493123, 2162465; Product type e : enzyme YP_002386594.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386595.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002386596.1 catalyzes the phosphorylation of thiamine to thiamine phosphate YP_002386597.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides YP_002386598.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386599.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14766919, 20130027, 81256452, 92296775, 94042945, 99441207, 6265208; Product type e : enzyme YP_002386600.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6265208, 7984428 YP_002386601.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002386602.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089 YP_002386603.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386604.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14602898, 90158497, 92107993, 8465200; Product type f : factor YP_002386605.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386606.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_002386607.1 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone YP_002386608.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_002386609.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine YP_002386610.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_002386611.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386612.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386613.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate YP_002386614.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component YP_002386615.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component YP_002386616.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase YP_002386617.1 Evidence 6 : Doubtful CDS YP_002386618.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_002386619.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386620.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92105017; Product type r : regulator YP_002386621.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress YP_002386622.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_002386623.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis YP_002386624.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_002386625.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217; Product type e : enzyme YP_002386626.1 catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA YP_002386627.1 Converts isocitrate to alpha ketoglutarate YP_002386628.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386629.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002386630.1 Evidence 6 : Doubtful CDS YP_002386631.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16533062, 15453820; Product type pe : putative enzyme YP_002386632.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386633.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386634.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386635.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386636.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386637.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386638.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386639.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386640.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386641.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386642.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386643.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell YP_002386644.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums YP_002386645.1 blocks the formation of polar Z-ring septums YP_002386646.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386647.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386648.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386649.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15551868; Product type pe : putative enzyme YP_002386650.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386651.1 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization YP_002386652.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization YP_002386653.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein YP_002386654.1 involved in regulation of intracellular pH under alkaline conditions YP_002386655.1 Multifunctional regulator of fatty acid metabolism YP_002386656.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386657.1 catalyzes the oxidative deamination of D-amino acids YP_002386658.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA YP_002386659.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli YP_002386660.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine YP_002386661.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98317285; Product type e : enzyme YP_002386662.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11031114; Product type cp : cell process YP_002386663.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002386664.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386665.1 periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell YP_002386666.1 phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL YP_002386667.1 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone YP_002386668.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase YP_002386669.1 Positively regulates the dhaKLM operon from a sigma-70 promoter YP_002386670.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_002386671.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_002386672.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function YP_002386673.1 putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport YP_002386674.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_002386675.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_002386676.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein YP_002386677.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_002386678.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_002386679.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB YP_002386680.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10322010; Product type pr : putative regulator YP_002386681.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10322010; Product type pr : putative regulator YP_002386682.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_002386683.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type f : factor YP_002386684.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93266586, 94193576, 94292460; Product type t : transporter YP_002386685.1 in Escherichia coli this protein putatively regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions YP_002386686.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type r : regulator YP_002386687.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386688.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pf : putative factor YP_002386689.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase YP_002386690.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92276349, 92374842, 94083940, 2649492, 2657652, 2668029; Product type r : regulator YP_002386691.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386692.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91258310, 2657652, 2668029; Product type t : transporter YP_002386693.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 74167294, 89384449, 92121125, 2233673, 2668029, 2995309, 3053688, 3308846, 6094247; Product type e : enzyme YP_002386694.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 74167294, 89384449, 92121125, 1321049, 2832376, 3053688, 8383531, 8388253, 8664273, 9516445; Product type c : carrier YP_002386695.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89384449, 92121125, 9632249, 2832376; Product type f : factor YP_002386696.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 75114694, 89384449, 92121125, 2832376, 3053688; Product type c : carrier YP_002386697.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_002386698.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386699.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386700.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339606, 12912910, 9495753; Product type r : regulator YP_002386701.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose YP_002386702.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 94335643, 95267838, 95286558, 99355427, 2404280, 11298273; Product type r : regulator YP_002386703.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_002386704.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12783863, 4301680, 89291706, 91200315; Product type e : enzyme YP_002386705.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386706.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386707.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20256410, 86111605, 90256748, 92325017, 2015910, 9298646, 9600841, 2187863, 8740179, 9740056, 10972807; Product type t : transporter YP_002386708.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606, 93106975, 2187863; Product type t : transporter YP_002386709.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter YP_002386710.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter YP_002386711.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter YP_002386712.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein YP_002386713.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol) YP_002386714.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386715.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12220501, 12912904, 94224769, 98319474; Product type t : transporter YP_002386716.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_002386717.1 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins YP_002386718.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins YP_002386719.1 Involved in cell division; probably involved in intracellular septation YP_002386720.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386721.1 receptor for colicin S4 YP_002386722.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15388941, 3058546, 8455549 YP_002386723.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3058546, 8455549 YP_002386724.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386725.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_002386726.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_002386727.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate YP_002386728.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis YP_002386729.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_002386731.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386732.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386733.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA YP_002386734.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide YP_002386735.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386736.1 Evidence 6 : Doubtful CDS YP_002386737.1 SohB; periplasmic protein; member of the peptidase S49 family YP_002386738.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3029379, 7567469, 9868784 YP_002386739.1 Evidence 6 : Doubtful CDS YP_002386740.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_002386741.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation YP_002386742.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386743.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386744.1 Evidence 6 : Doubtful CDS YP_002386745.1 Catalyzes the conversion of citrate to isocitrate YP_002386746.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate YP_002386747.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89033893, 92104964; Product type e : enzyme YP_002386748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386749.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386750.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_002386751.1 involved in start site selection during the initiation of translation YP_002386752.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386753.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92078100, 2644204; Product type lp : lipoprotein YP_002386754.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16451192; Product type r : regulator YP_002386755.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386756.1 c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP YP_002386757.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction YP_002386758.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386759.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_002386760.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386761.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 10720487, 9634580; Product type t : transporter YP_002386762.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 10720487, 9634580, 1987159; Product type t : transporter YP_002386763.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter YP_002386764.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter YP_002386765.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter YP_002386766.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386767.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15590624; Product type t : transporter YP_002386768.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15590624; Product type e : enzyme YP_002386769.1 catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate YP_002386770.1 regulates genes involved in putrescine degradation YP_002386771.1 catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation YP_002386772.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150200, 15590624; Product type e : enzyme YP_002386773.1 putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate YP_002386774.1 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor YP_002386775.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF YP_002386776.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding YP_002386777.1 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock YP_002386778.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91295203, 97303082; Product type ph : phenotype YP_002386779.1 rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide YP_002386780.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386781.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386782.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386783.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386784.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386785.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386786.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386787.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386788.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11972617; Product type pe : putative enzyme YP_002386789.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386790.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20464934, 89327119, 9721282; Product type t : transporter YP_002386791.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002386792.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386793.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386794.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids YP_002386795.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein YP_002386796.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11747447, 11747448, 7499381; Product type e : enzyme YP_002386797.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12511517; Product type e : enzyme YP_002386798.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386800.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17366475; Product type pr : putative regulator YP_002386801.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438753, 9495761; Product type t : transporter YP_002386802.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386803.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386804.1 with UspC and UspD is involved in resistance to UV irradiation YP_002386805.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia YP_002386806.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88067749, 91161525, 94252990, 98125595, 1520330; Product type e : enzyme YP_002386807.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9829935, 2825131, 7567469; Product type t : transporter YP_002386808.1 Evidence 6 : Doubtful CDS YP_002386809.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9829935; Product type pe : putative enzyme YP_002386810.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9829935; Product type pe : putative enzyme YP_002386811.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9829935; Product type r : regulator YP_002386812.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386813.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16045609; Product type pe : putative enzyme YP_002386814.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386815.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386816.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA YP_002386817.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_002386818.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 12381839, 11849540, 9298646; Product type f : factor YP_002386819.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9642192; Product type t : transporter YP_002386820.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9025293; Product type pe : putative enzyme YP_002386821.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386822.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12892888, 8349564, 9025293; Product type f : factor YP_002386823.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4297266, 89123040, 90198524, 8349564, 9025293; Product type e : enzyme YP_002386824.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386825.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein YP_002386826.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386827.1 activator of genes involved in phenylacetic acid catabolism YP_002386828.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96213037, 97263463, 9043126; Product type e : enzyme YP_002386829.1 catalyzes the formation of phenylacetaldehyde from 2-phenylethylamine YP_002386830.1 catalyzes the ring cleavage reaction in phenylacetate degradation and the formation of 3-hydroxyacyl-CoA from crotonyl-CoA YP_002386831.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA YP_002386832.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; involved in phenylacetate degradation YP_002386833.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12846838, 9748275; Product type pe : putative enzyme YP_002386834.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12846838, 9748275; Product type pe : putative enzyme YP_002386835.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17259607, 11260461, 12846838, 9748275; Product type e : enzyme YP_002386836.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12846838, 9748275, 10766858; Product type e : enzyme YP_002386837.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_002386838.1 converts 3-hydroxyadipyl-CoA to beta-ketoadipyl-CoA in phenylacetate degradation YP_002386839.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16464851, 12846838, 9748275; Product type e : enzyme YP_002386840.1 catalyzes the thiolytic cleavage of beta-ketoadipyl-CoA to succinate and acetyl-CoA YP_002386841.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12846838, 9748275, 10766858; Product type e : enzyme YP_002386842.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12846838, 20229831, 9748275; Product type r : regulator YP_002386843.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12846838, 9748275; Product type pe : putative enzyme YP_002386844.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386845.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386846.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386847.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386848.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386849.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386850.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds YP_002386851.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain YP_002386852.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386853.1 NAD-linked YP_002386854.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9622357, 9019141, 1917845, 3780374; Product type e : enzyme YP_002386855.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm YP_002386856.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386857.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type r : regulator YP_002386858.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90008892, 92390356, 93259131, 6374654; Product type r : regulator YP_002386859.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002386860.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386861.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans YP_002386862.1 Evidence 6 : Doubtful CDS YP_002386863.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386864.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89364711; Product type e : enzyme YP_002386865.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386866.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94222856, 2060788; Product type t : transporter YP_002386867.1 with TehA confers resistance to tellurite YP_002386868.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein YP_002386869.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme YP_002386870.1 Evidence 7 : Gene remnant YP_002386871.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386872.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1885518; Product type pt : putative transporter YP_002386873.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002386874.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386875.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386876.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002386877.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15223311; Product type pr : putative regulator YP_002386878.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11683869; Product type pt : putative transporter YP_002386879.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386880.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386881.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386882.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation YP_002386883.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8257133, 11841212, 12771141; Product type pe : putative enzyme YP_002386884.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386885.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386886.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386887.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386888.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386889.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11004173; Product type pr : putative regulator YP_002386890.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor YP_002386891.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386892.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76005443; Product type t : transporter YP_002386893.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386894.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 98361897, 1766878, 2403547, 2644231, 7934896; Product type h : extrachromosomal origin YP_002386895.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9696756 YP_002386896.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386897.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386898.1 Evidence 5 : No homology to any previously reported sequences YP_002386899.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1766878, 2644231, 2403547, 7934896 YP_002386900.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9696756 YP_002386901.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown YP_002386902.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386903.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20267568; Product type e : enzyme YP_002386904.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14611652, 15103639, 2233673 YP_002386905.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type e : enzyme YP_002386906.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410, 92186712; Product type f : factor YP_002386907.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type c : carrier YP_002386908.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type e : enzyme YP_002386909.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95266795, 2233673; Product type t : transporter YP_002386910.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386911.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7926834; Product type m : membrane component YP_002386912.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12410826; Product type t : transporter YP_002386913.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme YP_002386914.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76005553, 90375017, 92332427, 11884747, 1834669; Product type c : carrier YP_002386915.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase YP_002386916.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002386917.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs YP_002386918.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate YP_002386919.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10498711, 13129944; Product type f : factor YP_002386920.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14512736, 91350191, 9298646; Product type m : membrane component YP_002386921.1 catalyzes the formation of acetoacetate from 3-hydroxybutyrate YP_002386922.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386923.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386924.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386925.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9385134; Product type e : enzyme YP_002386926.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9385134; Product type e : enzyme YP_002386927.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type r : regulator YP_002386928.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter YP_002386929.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter YP_002386930.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter YP_002386931.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter YP_002386932.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter YP_002386933.1 catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis YP_002386934.1 heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate YP_002386935.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16497924, 15142243; Product type pe : putative enzyme YP_002386936.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10960106; Product type lp : lipoprotein YP_002386937.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15795232, 15489450; Product type t : transporter YP_002386938.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12912902, 92155241, 92394884, 99406302, 8455549; Product type e : enzyme YP_002386939.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1659611, 11514505; Product type pe : putative enzyme YP_002386940.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386941.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386942.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pr : putative regulator YP_002386943.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386944.1 regulates the cellular response to acid resistance YP_002386945.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386946.1 in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase family YP_002386947.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002386948.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002386949.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002386950.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002386951.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor YP_002386953.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002386954.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002386955.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358364, 94292428, 15576765; Product type r : regulator YP_002386956.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358364, 94292428, 15576765, 8021189; Product type r : regulator YP_002386957.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386958.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15601708, 14622426; Product type e : enzyme YP_002386959.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16321939, 15601708, 14622426; Product type r : regulator YP_002386960.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12657059, 11722742; Product type t : transporter YP_002386961.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11722742; Product type t : transporter YP_002386962.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11722742; Product type t : transporter YP_002386963.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11722742; Product type t : transporter YP_002386964.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386965.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386966.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate YP_002386967.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002386968.1 catalyzes the formation of D-tagaturonate from D-altronate YP_002386969.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386970.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386971.1 catalyzes the formation of glutamate from glutamine YP_002386972.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase YP_002386973.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002386974.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10094697, 99369894, 8383113, 10438792; Product type t : transporter YP_002386975.1 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function YP_002386976.1 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes YP_002386977.1 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF YP_002386978.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8383113 YP_002386979.1 converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism YP_002386980.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386981.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386982.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386983.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386984.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002386985.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20305052; Product type t : transporter YP_002386986.1 YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters YP_002386987.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386988.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386989.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386990.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 216006, 8226676; Product type e : enzyme YP_002386991.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine YP_002386992.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002386993.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12084818; Product type pc : putative carrier YP_002386994.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002386995.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002386996.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002386997.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14687564; Product type pe : putative enzyme YP_002386998.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor YP_002386999.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002387000.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002387001.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002387002.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002387003.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002387004.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002387005.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002387006.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002387007.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002387008.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002387009.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002387010.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002387011.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002387012.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002387013.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin YP_002387014.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin YP_002387015.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin YP_002387016.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin YP_002387017.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin YP_002387018.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin YP_002387019.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11302702; Product type h : extrachromosomal origin YP_002387020.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin YP_002387021.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92334985; Product type h : extrachromosomal origin YP_002387022.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387023.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002387024.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002387025.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21429224; Product type h : extrachromosomal origin YP_002387026.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387027.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9484881; Product type h : extrachromosomal origin YP_002387028.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002387029.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387030.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002387031.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor YP_002387032.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293754, 94293756, 9439003; Product type h : extrachromosomal origin YP_002387033.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9484881, 8022261, 9439003; Product type h : extrachromosomal origin YP_002387034.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor YP_002387035.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002387036.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2990907; Product type h : extrachromosomal origin YP_002387037.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21592958, 99141390, 2990907; Product type h : extrachromosomal origin YP_002387038.1 Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor YP_002387039.1 Evidence 5 : No homology to any previously reported sequences YP_002387040.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9358034; Product type h : extrachromosomal origin YP_002387041.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387042.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387043.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387044.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387045.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002387046.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387047.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387048.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88232418, 3532030; Product type h : extrachromosomal origin YP_002387049.1 The transcriptional repressor of DicA (divison cell) has a hypothetical DNA binding domain. It represses the transcription of dicB and dicC, but its specific role in cellular replication and mode of action are still unknown. YP_002387050.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002387051.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002387052.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002387053.1 Evidence 6 : Doubtful CDS YP_002387054.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002387055.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002387056.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002387057.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002387058.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387059.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387060.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7545940; Product type pe : putative enzyme YP_002387061.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 93341455, 94310441; Product type pe : putative enzyme YP_002387062.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387063.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387064.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94357898; Product type e : enzyme YP_002387065.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387066.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9868784 YP_002387067.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type e : enzyme YP_002387068.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type e : enzyme YP_002387069.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type c : carrier YP_002387070.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type m : membrane component YP_002387071.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane YP_002387072.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12384697; Product type pt : putative transporter YP_002387073.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_002387074.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10318813, 20490366, 6989798, 99340206, 99395104, 99398866, 7766024; Product type r : regulator YP_002387075.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002387076.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387077.1 required for growth and survival under moderately acid conditions YP_002387078.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387079.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS YP_002387080.1 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS YP_002387081.1 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes YP_002387082.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme YP_002387083.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm YP_002387084.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387085.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1311296; Product type pt : putative transporter YP_002387086.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14617668; Product type e : enzyme YP_002387087.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387088.1 response regulator in two-component regulatory system with RstB YP_002387089.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93086426, 1495392, 1925016, 2646639; Product type r : regulator YP_002387090.1 binds to DNA replication terminator sequences to prevent passage of replication forks YP_002387091.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_002387092.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88193096, 88268900, 92011457, 3005475, 6328431, 9298646; Product type e : enzyme YP_002387093.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82100097, 6397402; Product type e : enzyme YP_002387094.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387095.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15774881; Product type t : transporter YP_002387096.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3534890; Product type t : transporter YP_002387097.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87041472, 88038341, 2103475, 8125312; Product type e : enzyme YP_002387098.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88038341, 2823062, 3934044, 11115104; Product type r : regulator YP_002387099.1 Acts on the hydroxyl group at position 7 of the steroid frame YP_002387100.1 regulates malXY which are involved in maltose-glucose transport YP_002387101.1 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site YP_002387102.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20164451, 7665481, 91310596; Product type e : enzyme YP_002387103.1 catalyzes the formation of inosine from adenosine YP_002387104.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387105.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20392465, 10931331; Product type m : membrane component YP_002387106.1 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes YP_002387107.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387108.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411911, 10637328, 12773378; Product type pm : putative membrane component YP_002387109.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_002387110.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_002387111.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents YP_002387112.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen YP_002387113.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase YP_002387114.1 DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines YP_002387115.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation YP_002387116.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95096109, 2185038, 9680481; Product type e : enzyme YP_002387117.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_002387118.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_002387119.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate YP_002387120.1 MliC; membrane-bound lysozyme inhibitor of c-type lysozyme YP_002387121.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_002387122.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8544813; Product type lp : lipoprotein YP_002387123.1 Transcription regulator that can both activate or repress expression YP_002387124.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387125.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12900028; Product type e : enzyme YP_002387126.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387127.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water YP_002387128.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387129.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387130.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002387131.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide YP_002387132.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione YP_002387133.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) YP_002387134.1 similar to the DNA and RNA helicase superfamily II and eukaryotic DEAD family of helicases; longest known protein in E. coli YP_002387135.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15833738, 15840565, 11950925, 12730244; Product type e : enzyme YP_002387136.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387137.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals YP_002387138.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387139.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers YP_002387140.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2404765; Product type pr : putative regulator YP_002387141.1 uncharacterized member of the major facilitator superfamily (MFS) YP_002387142.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge YP_002387143.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_002387144.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones YP_002387145.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387146.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387147.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387148.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387149.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002387150.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002387151.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387152.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387153.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002387154.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387155.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002387156.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 334727, 338599, 322142, 353292, 391404, 4261992, 4575979, 6765942; Product type lp : lipoprotein YP_002387157.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387158.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine YP_002387159.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine YP_002387160.1 with SufBC activates cysteine desulfurase SufS YP_002387161.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE YP_002387162.1 with SufCD activates cysteine desulfurase SufS YP_002387163.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein YP_002387164.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387165.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme YP_002387166.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11102686; Product type pe : putative enzyme YP_002387167.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function YP_002387168.1 Evidence 6 : Doubtful CDS YP_002387169.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387170.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387171.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387172.1 YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate YP_002387173.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis YP_002387174.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16253988; Product type e : enzyme YP_002387175.1 may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain YP_002387176.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002387177.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387178.1 YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain YP_002387179.1 May play a role in a redox process YP_002387180.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002387181.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002387182.1 acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids YP_002387183.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002387184.1 Evidence 6 : Doubtful CDS YP_002387185.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387186.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate YP_002387187.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15039350 YP_002387188.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387189.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12620121; Product type lp : lipoprotein YP_002387190.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell YP_002387191.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane YP_002387192.1 with BtuD and BtuF transports vitamin B12 into the cell YP_002387193.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_002387194.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_002387195.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_002387197.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_002387198.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93085722, 10094780, 3298224, 3542048, 6325158; Product type s : structure YP_002387199.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002387200.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387201.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387202.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 78194149, 88292964, 6235149, 6310120; Product type e : enzyme YP_002387203.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387204.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387205.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387206.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate YP_002387207.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10760155; Product type pm : putative membrane component YP_002387209.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387210.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9427399; Product type cp : cell process YP_002387211.1 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide YP_002387212.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 20042356, 1987146, 2179047, 8121401, 9405618 YP_002387213.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20042356, 90185127, 9405618; Product type e : enzyme YP_002387214.1 represses the celABCDF-ydjC operon involved in carbon uptake YP_002387215.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_002387216.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_002387217.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_002387218.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein YP_002387219.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_002387220.1 3' incision activity; acts with UvrC YP_002387221.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21862596 YP_002387222.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP YP_002387223.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism YP_002387224.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation YP_002387225.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH YP_002387226.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14675764, 98361920; Product type e : enzyme YP_002387227.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate YP_002387228.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction YP_002387229.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387230.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387231.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387232.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387233.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387234.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387235.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387236.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387237.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type m : membrane component YP_002387238.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101911; Product type e : enzyme YP_002387239.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387240.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_002387241.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387242.1 decatenates replicating daughter chromosomes YP_002387243.1 catalyzes the formation of selenophosphate from selenide and ATP YP_002387244.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387245.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387246.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387247.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane YP_002387248.1 converts asparagine to aspartate and ammonia YP_002387249.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide YP_002387250.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387251.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002387252.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387253.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387254.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387255.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12897001; Product type pe : putative enzyme YP_002387256.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387257.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387258.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387259.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_002387260.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 775311, 94131963, 98361923, 1862091, 2124629, 2990926, 7896119, 8636984, 9298646; Product type e : enzyme YP_002387261.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387262.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387263.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10037771, 20267815; Product type f : factor YP_002387264.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387265.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387266.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387267.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387268.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387269.1 Evidence 6 : Doubtful CDS YP_002387270.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387271.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002387272.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387273.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387274.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387275.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387276.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387277.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387278.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387279.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387280.1 Evidence 6 : Doubtful CDS YP_002387281.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387282.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387283.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387284.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002387285.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387286.1 member of the betaine, carnitine, choline transporter (BCCT) family; unknown function YP_002387287.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002387288.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387289.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88289400, 89053950, 93015723, 8107670; Product type e : enzyme YP_002387290.1 Activates fatty acids by binding to coenzyme A YP_002387291.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16079137; Product type lp : lipoprotein YP_002387292.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387293.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387294.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387295.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387296.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387297.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88025006, 91067712, 91302313, 96011382, 6330050, 7896119; Product type e : enzyme YP_002387298.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pe : putative enzyme YP_002387299.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15155761, 89359152, 91056090, 93170282; Product type e : enzyme YP_002387300.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16513732; Product type pe : putative enzyme YP_002387301.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002387302.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87165962, 90036983, 8131846, 8676384, 9074635, 9298646; Product type t : transporter YP_002387303.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10473571, 87165962, 90036983, 94086520, 97128775, 7811395, 8774730; Product type t : transporter YP_002387304.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel YP_002387305.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387306.1 Evidence 6 : Doubtful CDS YP_002387307.1 membrane protein YebN YP_002387308.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth YP_002387309.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20345064, 21101802, 94293754, 12071744, 7984109, 8022261, 9298646, 9868784, 9921691; Product type f : factor YP_002387310.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387311.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387312.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387313.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387314.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659677, 4359651; Product type r : regulator YP_002387315.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387316.1 putative metalloprotease YP_002387317.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 YP_002387318.1 affects solute and DNA transport through an unknown mechanism YP_002387319.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387320.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387321.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387322.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA YP_002387323.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387324.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387325.1 Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins YP_002387326.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387327.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387328.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387329.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15090519, 92147649, 92156151, 94131961, 1575709, 8341603, 8505306; Product type e : enzyme YP_002387330.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387331.1 3'-5' exonuclease activity on single or double-strand DNA YP_002387332.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues YP_002387333.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387334.1 secreted protein; unknown function YP_002387335.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9368369, 99403401; Product type cp : cell process YP_002387336.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_002387337.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_002387338.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_002387339.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_002387340.1 Represses the expression of the zwf, eda, glp and gap YP_002387341.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002387342.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387343.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387344.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387345.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2482332, 12547200; Product type e : enzyme YP_002387346.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8594196; Product type t : transporter YP_002387347.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8594196; Product type pt : putative transporter YP_002387348.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8594196; Product type pt : putative transporter YP_002387349.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8594196; Product type pt : putative transporter YP_002387350.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8594196; Product type pe : putative enzyme YP_002387351.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology YP_002387352.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8594196; Product type t : transporter YP_002387353.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8594196 YP_002387354.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387355.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387356.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA YP_002387357.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1732206; Product type pe : putative enzyme YP_002387358.1 involved in transport of zinc(II) with ZnuA and C YP_002387359.1 involved in transport of zinc(II) with ZnuA and C YP_002387360.1 involved in transport of zinc(II) with ZnuA and C YP_002387361.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_002387362.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_002387363.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387364.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_002387365.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387366.1 converts dATP to dAMP and pyrophosphate YP_002387367.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_002387368.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387369.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2129559, 7984428 YP_002387370.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387371.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11746687; Product type e : enzyme YP_002387372.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387373.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97077292, 11004177; Product type e : enzyme YP_002387374.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461225, 8919859; Product type c : carrier YP_002387375.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95362641, 7635807; Product type t : transporter YP_002387376.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12660999; Product type pe : putative enzyme YP_002387377.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_002387378.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387379.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8002587, 1482109, 89181349 YP_002387380.1 membrane protein involved in the flagellar export apparatus YP_002387381.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_002387382.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation YP_002387383.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble YP_002387384.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_002387385.1 methylates the MCP YP_002387386.1 mediates taxis toward dipeptides YP_002387387.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90094243, 92165727, 6305515, 9315712; Product type r : regulator YP_002387388.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91126073, 91296802, 91317710, 2002011, 3510184; Product type r : regulator YP_002387389.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component YP_002387390.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_002387391.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_002387392.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems YP_002387393.1 with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems YP_002387394.1 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress YP_002387395.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92078100, 92121128, 93302496, 8045430; Product type e : enzyme YP_002387396.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature YP_002387397.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_002387398.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_002387399.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89255061, 90375534, 2445996, 326784, 326785, 6885805, 7031057, 9298646; Product type t : transporter YP_002387400.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002387401.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387402.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387403.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387404.1 cytoplasmic iron storage protein YP_002387405.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387406.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89008121, 2022620; Product type t : transporter YP_002387407.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387408.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 381294, 7007311, 94253011, 1323047, 3003065, 8917447; Product type e : enzyme YP_002387409.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_002387410.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system YP_002387411.1 Evidence 6 : Doubtful CDS YP_002387412.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3515318, 7567469 YP_002387413.1 regulates genes involved in cell division YP_002387414.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387415.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387416.1 catalyzes the formation of pyruvate from D-cysteine YP_002387417.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96125225, 8450713, 8774726, 9298646, 9740056; Product type t : transporter YP_002387418.1 expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence YP_002387419.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes YP_002387421.1 structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes YP_002387422.1 involved in flagellin assembly YP_002387423.1 flagellin specific chaperone YP_002387424.1 binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family YP_002387425.1 converts 1,4-alpha-D-glucans to maltodextrin YP_002387426.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387427.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387428.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387429.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387430.1 forms a junction between the M-ring and FlgB during flagella biosynthesis YP_002387431.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_002387432.1 One of three proteins involved in switching the direction of the flagellar rotation YP_002387433.1 binds to and inhibits the function of flagella specific ATPase FliI YP_002387434.1 involved in type III protein export during flagellum assembly YP_002387435.1 rod/hook and filament chaperone YP_002387436.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1482109, 8631687; Product type s : structure YP_002387437.1 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring YP_002387438.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation YP_002387439.1 One of three proteins involved in switching the direction of the flagellar rotation YP_002387440.1 with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus YP_002387441.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_002387442.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus YP_002387443.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus YP_002387444.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14514676, 14766922, 20167175, 90130299, 91154130, 92048476, 9882673, 7534408; Product type r : regulator YP_002387445.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 96324407, 7534408 YP_002387446.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387447.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate YP_002387448.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16530465; Product type pe : putative enzyme YP_002387449.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387450.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387451.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387452.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387453.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330522, 92049708, 94049122, 10360178, 10612397, 10871403, 2527357; Product type e : enzyme YP_002387454.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90280700, 91285397, 93367813, 2198248, 2527357; Product type e : enzyme YP_002387455.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pe : putative enzyme YP_002387456.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387457.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9642192; Product type m : membrane component YP_002387458.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress YP_002387459.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15522865; Product type rc : receptor YP_002387460.1 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced YP_002387461.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387462.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ YP_002387463.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme YP_002387464.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12077457, 12480884, 12909634, 9579078 YP_002387465.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16042411; Product type pc : putative carrier YP_002387466.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387467.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659678; Product type f : factor YP_002387468.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type h : extrachromosomal origin YP_002387469.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type h : extrachromosomal origin YP_002387470.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387471.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 5332864, 9524262; Product type t : transporter YP_002387472.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile YP_002387473.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387474.1 Evidence 6 : Doubtful CDS YP_002387475.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16042411; Product type pt : putative transporter YP_002387476.1 LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB YP_002387477.1 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation YP_002387478.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9298646 YP_002387479.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole YP_002387480.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole YP_002387481.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP YP_002387482.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387483.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387484.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11850398, 9442027, 8709849; Product type r : regulator YP_002387485.1 removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_002387486.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates YP_002387487.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387488.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387489.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387490.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002387491.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387492.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type f : factor YP_002387493.1 Antitoxin that counteracts the effect of the YoeB toxin YP_002387495.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_002387496.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_002387497.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_002387498.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate YP_002387499.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_002387500.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_002387501.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_002387502.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis YP_002387503.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10768928, 9370271, 9573168, 11964144, 4295288, 7536735; Product type e : enzyme YP_002387504.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10768928, 7536735, 8162191; Product type e : enzyme YP_002387505.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9573168, 10768928; Product type e : enzyme YP_002387506.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9573168, 10768928; Product type pe : putative enzyme YP_002387507.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10768928, 9573168, 9244257; Product type t : transporter YP_002387508.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10768928, 9573168, 9244257; Product type m : membrane component YP_002387509.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7515042, 9004408; Product type e : enzyme YP_002387510.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7896702, 7515042, 9004408, 14993253; Product type e : enzyme YP_002387511.1 Evidence 5 : No homology to any previously reported sequences YP_002387513.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98241528; Product type r : regulator YP_002387514.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150218, 96326333; Product type e : enzyme YP_002387515.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_002387516.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387517.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387518.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387519.1 Evidence 6 : Doubtful CDS YP_002387520.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387521.1 Evidence 5 : No homology to any previously reported sequences YP_002387522.1 together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose YP_002387523.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976290; Product type e : enzyme YP_002387524.1 WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid YP_002387525.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme YP_002387526.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333, 8759852, 11004393; Product type pe : putative enzyme YP_002387527.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 8759852; Product type pt : putative transporter YP_002387528.1 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid YP_002387529.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106949, 96326333, 7815923, 8759852; Product type e : enzyme YP_002387530.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82100097, 85006781, 92048476, 93122523, 96326333, 7815923, 8759852; Product type e : enzyme YP_002387531.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15670885, 96326333; Product type pe : putative enzyme YP_002387532.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 10913267, 7592609, 7815923, 8759852; Product type e : enzyme YP_002387533.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 98132401, 9862812, 7815923, 8759852, 9473059; Product type e : enzyme YP_002387534.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20139699, 97400210, 10673432, 7815923, 8759852, 9257704, 14299611; Product type e : enzyme YP_002387535.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit) YP_002387536.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11371548, 96326333, 8759852; Product type pe : putative enzyme YP_002387537.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance YP_002387538.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme YP_002387539.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium YP_002387540.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme YP_002387541.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide) YP_002387542.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis YP_002387543.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15090537, 96326333, 8759852, 8763957; Product type lp : lipoprotein YP_002387544.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002387545.1 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs YP_002387546.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_002387547.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_002387548.1 contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction YP_002387549.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine YP_002387550.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 6094528, 7940673, 7984428; Product type pf : putative factor YP_002387551.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387552.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387553.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387554.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate YP_002387555.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate YP_002387556.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate YP_002387557.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12107134, 21450803, 8282725; Product type t : transporter YP_002387558.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94110256, 8282725; Product type r : regulator YP_002387559.1 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport YP_002387560.1 Evidence 6 : Doubtful CDS YP_002387561.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387562.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387563.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387564.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387565.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387566.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387567.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role YP_002387568.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7772602; Product type r : regulator YP_002387569.1 Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate YP_002387570.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76024805, 77192083, 97113438, 7772602; Product type t : transporter YP_002387571.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002387572.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002387573.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976750, 97113438, 7772602, 8932697; Product type e : enzyme YP_002387574.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway YP_002387575.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate YP_002387576.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387577.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387578.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387579.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002387580.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387581.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_002387582.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP YP_002387583.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387584.1 membrane protein conferring nickel and cobalt resistance YP_002387585.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387586.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002387587.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387588.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor YP_002387589.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002387590.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387591.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91080852, 15601724, 2259334; Product type t : transporter YP_002387592.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_002387593.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2156810; Product type pr : putative regulator YP_002387594.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387595.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387596.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16428726; Product type pf : putative factor YP_002387597.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387598.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387599.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387600.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type lp : lipoprotein YP_002387601.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387602.1 unknown function; when overproduced it confers drug-resistance YP_002387603.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15522865, 15322361; Product type rc : receptor YP_002387604.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11489123; Product type r : regulator YP_002387605.1 Evidence 5 : No homology to any previously reported sequences YP_002387606.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387607.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387608.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387609.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387610.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15251200; Product type pt : putative transporter YP_002387611.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96303506; Product type e : enzyme YP_002387612.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent YP_002387613.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7 YP_002387614.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387615.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387616.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387617.1 may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride YP_002387618.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566; Product type e : enzyme YP_002387619.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387620.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387621.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_002387622.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 96125233, 1567863, 8550448 YP_002387623.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387624.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain YP_002387625.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines YP_002387626.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex YP_002387627.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains YP_002387628.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87286407, 92049246, 1719366, 3057628, 3302609, 3600760, 6340108, 6885805, 7012152, 9298646; Product type t : transporter YP_002387629.1 negative regulator of the mglBAC operon for galactose utilization YP_002387630.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387631.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387632.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_002387633.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387634.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16567800; Product type e : enzyme YP_002387635.1 Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein YP_002387636.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387637.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92250419, 94252996, 1315732, 7551055; Product type t : transporter YP_002387638.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12400704, 1315732; Product type pr : putative regulator YP_002387639.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387640.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues YP_002387641.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387642.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387643.1 Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively YP_002387644.1 activator of nucleoside metabolism YP_002387645.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387646.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387647.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387648.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002387649.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers YP_002387650.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr YP_002387651.1 Evidence 6 : Doubtful CDS YP_002387652.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438463, 10209755; Product type t : transporter YP_002387653.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387654.1 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein YP_002387655.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387656.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387657.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15778224; Product type e : enzyme YP_002387658.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance YP_002387659.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387660.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387661.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387662.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387663.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387664.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387665.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance YP_002387666.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA YP_002387667.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387668.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_002387669.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99296598, 10368163; Product type f : factor YP_002387670.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387671.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387672.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387673.1 Evidence 6 : Doubtful CDS YP_002387674.1 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes YP_002387675.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 11756453, 12196152, 87260957, 91194558, 95362656, 9914305, 7635817; Product type pe : putative enzyme YP_002387676.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 9716493, 9770295, 11256948, 11350062, 11843181, 7635817, 9537397; Product type e : enzyme YP_002387677.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 11756453, 12196152, 87260957, 8842153, 91194558, 95362656, 9716493, 7635817; Product type e : enzyme YP_002387678.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_002387679.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 95362656, 9716493, 7635817; Product type f : factor YP_002387680.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 14532274, 21413853, 95362656, 7635817; Product type t : transporter YP_002387681.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 95362656, 9716493, 7635817; Product type t : transporter YP_002387682.1 ATP-binding protein; required for proper cytochrome c maturation YP_002387683.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone YP_002387684.1 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA YP_002387685.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA YP_002387686.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway YP_002387687.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC YP_002387688.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96228696, 99395037; Product type f : factor YP_002387689.1 Predicted role in electron transfer to the periplasmic nitrate reductase protein NapA. YP_002387690.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387691.1 serine protease inhibitor, inhibits trypsin and other proteases YP_002387692.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_002387693.1 efflux pump for the antibacterial peptide microcin J25 YP_002387694.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12226668, 12517444, 12862460, 14527653, 87057220, 88151899, 92017669, 3536913, 3887409, 7928996; Product type e : enzyme YP_002387695.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91073391, 93272965, 94252990; Product type r : regulator YP_002387696.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway YP_002387697.1 allows for ions and hydrophilic solutes to cross the outer membrane YP_002387698.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11758943, 12864862, 21206231, 2404948, 7984428; Product type r : regulator YP_002387699.1 two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF YP_002387700.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11758943, 12864862, 14651646, 20032358, 21450811, 88227838, 90130299, 92048476, 9209051, 2404948, 8366025; Product type r : regulator YP_002387701.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387702.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387703.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002387704.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387705.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387706.1 Evidence 6 : Doubtful CDS YP_002387707.1 negatively supercoils closed circular double-stranded DNA YP_002387708.1 Involved in ubiquinone biosynthesis YP_002387709.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659678; Product type f : factor YP_002387710.1 Catalyzes the rate-limiting step in dNTP synthesis YP_002387711.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA YP_002387712.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases YP_002387713.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 92165728, 1537798, 6087316 YP_002387714.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387715.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic YP_002387716.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell YP_002387717.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor YP_002387718.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters YP_002387719.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate YP_002387720.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387721.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387722.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387723.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16430214; Product type pe : putative enzyme YP_002387724.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387725.1 catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose YP_002387726.1 catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate YP_002387727.1 Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains YP_002387728.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387729.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A YP_002387730.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387731.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387732.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96015440, 15569938; Product type pt : putative transporter YP_002387733.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96186953, 8626063; Product type e : enzyme YP_002387734.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate YP_002387735.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_002387736.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA YP_002387737.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis YP_002387738.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150206, 96140724, 2666397, 7984428, 8549818, 8764478; Product type e : enzyme YP_002387739.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387740.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387741.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions YP_002387742.1 ElaD; specific cysteine protease which targets ubiquitin and ubiquitin-like proteins covalently bound to target proteins; SseL in Salmonella is required for macrophage killing and virulence, and it is secreted by the salmonella pathogenicity island 2 type III secretion system YP_002387743.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387744.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387745.1 Catalyzes the transfer of electrons from NADH to quinone YP_002387746.1 Catalyzes the transfer of electrons from NADH to quinone YP_002387747.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_002387748.1 Catalyzes the transfer of electrons from NADH to quinone YP_002387749.1 Catalyzes the transfer of electrons from NADH to quinone YP_002387750.1 Catalyzes the transfer of electrons from NADH to quinone YP_002387751.1 Catalyzes the transfer of electrons from NADH to quinone YP_002387752.1 Catalyzes the transfer of electrons from NADH to quinone YP_002387753.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase YP_002387754.1 Catalyzes the transfer of electrons from NADH to quinone YP_002387755.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms YP_002387756.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_002387757.1 Catalyzes the transfer of electrons from NADH to quinone YP_002387758.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123461, 9882671, 7565112; Product type r : regulator YP_002387759.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_002387760.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15489502; Product type e : enzyme YP_002387761.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387762.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387763.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387764.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387766.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_002387767.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_002387768.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16430214; Product type pe : putative enzyme YP_002387769.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387770.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387771.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387772.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate YP_002387773.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : putative enzyme YP_002387774.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387775.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 3313284, 91060556; Product type t : transporter YP_002387776.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 3313284; Product type t : transporter YP_002387777.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434; Product type t : transporter YP_002387778.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 6449635, 8161536, 9298646, 9600841, 9740056; Product type t : transporter YP_002387779.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate YP_002387780.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_002387781.1 membrane protein required for colicin V production YP_002387782.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3040734 YP_002387783.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3040739, 91112811, 92041808, 1989505, 3040734; Product type e : enzyme YP_002387784.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_002387785.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3029016, 3040734, 7678242; Product type pm : putative membrane component YP_002387786.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_002387787.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 92380957, 92380982, 93123150, 2681152, 2991861, 3029016; Product type pe : putative enzyme YP_002387788.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90036695, 91035267, 2681152, 2991861, 3029016; Product type e : enzyme YP_002387789.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein YP_002387790.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387791.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_002387792.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules YP_002387793.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387794.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387795.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387796.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm YP_002387797.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_002387798.1 involved in methylation of ribosomal protein L3 YP_002387799.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387800.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme YP_002387801.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387802.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002387803.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002387804.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002387805.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor YP_002387806.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387807.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002387808.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10089421, 20200300, 9489669; Product type e : enzyme YP_002387809.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate YP_002387810.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth YP_002387811.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387812.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15178802, 2840553, 3286621, 91100327, 1987139, 9119048; Product type t : transporter YP_002387813.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387814.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8145644, 15352239; Product type lp : lipoprotein YP_002387815.1 Evidence 6 : Doubtful CDS YP_002387816.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387817.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments YP_002387818.1 phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least YP_002387819.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12218016; Product type e : enzyme YP_002387820.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator YP_002387821.1 catalyzes the formation of pyruvate from serine YP_002387822.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20378313; Product type pt : putative transporter YP_002387823.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20378313; Product type t : transporter YP_002387824.1 response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance YP_002387825.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14523115, 93173621, 9501520, 10923791, 1289796, 8125343, 9535079; Product type r : regulator YP_002387826.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387827.1 member of the AEC family of auxin efflux transporters; unknown function YP_002387828.1 catalyzes the formation of formyl-CoA from oxalyl-CoA YP_002387829.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA YP_002387830.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11157960 YP_002387831.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15183873; Product type lp : lipoprotein YP_002387832.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089; Product type pm : putative membrane component YP_002387834.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock YP_002387835.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387836.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15522865; Product type prc : putative receptor YP_002387837.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15522865; Product type pr : putative regulator YP_002387838.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002387839.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387840.1 metalloprotein YP_002387841.1 Xaa-Pro aminopeptidase; limited methionine aminopeptidase YP_002387842.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387843.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387844.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate YP_002387845.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387846.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387847.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20177822, 20305051, 10712688, 10844693; Product type t : transporter YP_002387848.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 374403, 8022285, 7007808, 827549, 4563236, 1512211; Product type t : transporter YP_002387849.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387850.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002387851.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002387852.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_002387853.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387854.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002387855.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002387856.1 Evidence 6 : Doubtful CDS YP_002387857.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_002387858.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure YP_002387859.1 putative role in sulfur assimilation YP_002387860.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis YP_002387861.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type t : transporter YP_002387862.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system YP_002387863.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose YP_002387864.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_002387865.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387866.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide YP_002387867.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202710, 90264334, 2188958, 7665461; Product type t : transporter YP_002387868.1 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import YP_002387869.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264334, 2188958; Product type t : transporter YP_002387870.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264335, 2188959, 9298646; Product type t : transporter YP_002387871.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 97385354, 2188959, 7984428, 9241368; Product type pe : putative enzyme YP_002387872.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002387873.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_002387874.1 belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component YP_002387875.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15983044, 15060041; Product type e : enzyme YP_002387876.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387877.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12900013, 7764507 YP_002387878.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387879.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387880.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21348478, 6137479, 87242501, 1903834, 8300522; Product type e : enzyme YP_002387881.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_002387882.1 activates the transcription of the ethanolamine utilization operon YP_002387883.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10464203; Product type ps : putative structure YP_002387884.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure YP_002387885.1 catalyzes the formation of acetaldehyde from ethanolamine YP_002387886.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3905806, 10464203; Product type e : enzyme YP_002387887.1 ethanolamine utilization protein EutA YP_002387888.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7868611, 10464203; Product type pt : putative transporter YP_002387889.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme YP_002387890.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pf : putative factor YP_002387891.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme YP_002387892.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure YP_002387893.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure YP_002387894.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta YP_002387895.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme YP_002387896.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10464203 YP_002387897.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme YP_002387898.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure YP_002387899.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_002387900.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90230300; Product type e : enzyme YP_002387901.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_002387902.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387903.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387904.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic) YP_002387905.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92374842, 1508040, 1528845; Product type r : regulator YP_002387906.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12426336, 20158894, 21450803, 79216220, 10692383, 1644752; Product type t : transporter YP_002387907.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387908.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_002387909.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387910.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate YP_002387911.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387912.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387913.1 stability determinant protein YP_002387914.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387915.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_002387916.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358331, 1885529, 2120198; Product type lp : lipoprotein YP_002387917.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_002387918.1 negative transcriptional regulator of the gcvTHP operon YP_002387919.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine YP_002387920.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241, 2016588; Product type c : carrier YP_002387921.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component YP_002387922.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component YP_002387923.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component YP_002387924.1 interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide YP_002387925.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component YP_002387926.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type c : carrier YP_002387927.1 probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far YP_002387928.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type c : carrier YP_002387929.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9387241; Product type pf : putative factor YP_002387930.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type r : regulator YP_002387931.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387932.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387933.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387934.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP YP_002387935.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8332529, 7721693; Product type t : transporter YP_002387936.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_002387937.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_002387938.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_002387939.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_002387940.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93107072, 94025037, 94165003, 8212131, 8380170; Product type e : enzyme YP_002387941.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387942.1 Evidence 6 : Doubtful CDS YP_002387943.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002387944.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387945.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_002387946.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_002387947.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_002387948.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387949.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_002387950.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis YP_002387951.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387952.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_002387953.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_002387954.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387955.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_002387956.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_002387957.1 penicillin-insensitive transglycosylase/transpeptidase YP_002387958.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387959.1 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds YP_002387960.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I YP_002387961.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide YP_002387962.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10393315; Product type pf : putative factor YP_002387963.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10393315, 20013001, 92283811, 94181532, 11551196, 1317854, 4375562, 8300516; Product type c : carrier YP_002387964.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_002387965.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins YP_002387966.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein YP_002387967.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10393315, 11994302, 15153099; Product type f : factor YP_002387968.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_002387969.1 regulates the expression of the iscRSUA operon YP_002387970.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10393315; Product type pe : putative enzyme YP_002387971.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6389495, 90202735, 95095968, 10747806, 2138605, 8002619; Product type e : enzyme YP_002387972.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387973.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95020540, 96154950; Product type cp : cell process YP_002387974.1 putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters YP_002387975.1 activator of 3-phenylpropionic acid catabolism YP_002387976.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83238171, 87008429, 98269008; Product type e : enzyme YP_002387977.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83238171, 87008429, 98269008, 9603882; Product type e : enzyme YP_002387978.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98269008, 9603882; Product type pc : putative carrier YP_002387979.1 Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate YP_002387980.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002387981.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387982.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002387983.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387984.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002387985.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pt : putative transporter YP_002387986.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387987.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002387988.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_002387989.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine YP_002387990.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA YP_002387991.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8226691, 8412694; Product type pr : putative regulator YP_002387992.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387994.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002387995.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_002387996.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function YP_002387997.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12110595; Product type e : enzyme YP_002387998.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002387999.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388000.1 Evidence 5 : No homology to any previously reported sequences YP_002388001.1 Evidence 5 : No homology to any previously reported sequences YP_002388002.1 Evidence 6 : Doubtful CDS YP_002388003.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388004.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002388005.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002388007.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388008.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388009.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388010.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388011.1 Evidence 5 : No homology to any previously reported sequences YP_002388012.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002388013.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388014.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388015.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388016.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388017.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388018.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388019.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388020.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388021.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388022.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388023.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388024.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388025.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388026.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388027.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388028.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388029.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388030.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388031.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002388032.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002388033.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002388034.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2998005; Product type h : extrachromosomal origin YP_002388035.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin YP_002388036.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin YP_002388037.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388038.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor YP_002388039.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10489345; Product type f : factor YP_002388040.1 Evidence 6 : Doubtful CDS YP_002388041.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002388042.1 Evidence 6 : Doubtful CDS; Product type h : extrachromosomal origin YP_002388043.1 Evidence 5 : No homology to any previously reported sequences YP_002388044.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10489345 YP_002388045.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388046.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002388047.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10489345; Product type pe : putative enzyme YP_002388048.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388050.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10489345; Product type h : extrachromosomal origin YP_002388051.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002388052.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10489345; Product type h : extrachromosomal origin YP_002388053.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin YP_002388054.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002388055.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8765743, 8880900; Product type c : carrier YP_002388056.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388057.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_002388058.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_002388059.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_002388060.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_002388061.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_002388062.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins YP_002388063.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_002388065.1 involved in the reduction of the SoxR iron-sulfur cluster YP_002388066.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP YP_002388067.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9159522, 97303092, 99431977, 7768826; Product type f : factor YP_002388068.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_002388069.1 catalyzes the formation of oxaloacetate from L-aspartate YP_002388070.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388071.1 facilitates an early step in the assembly of the 50S subunit of the ribosome YP_002388072.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme YP_002388073.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388074.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12562784; Product type t : transporter YP_002388075.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit YP_002388076.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_002388077.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388078.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388079.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12952960, 9388228, 99175138, 10644706; Product type c : carrier YP_002388080.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388081.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme YP_002388082.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome YP_002388083.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388084.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91219460, 1709493, 2053984, 2118499, 2190187, 8419306; Product type t : transporter YP_002388085.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14550559, 14640692, 91294166, 93015925, 93388583, 99428468; Product type f : factor YP_002388086.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1906060, 2066329 YP_002388087.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA YP_002388088.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline YP_002388089.1 associated with 30S ribosomal subunit; interferes with translation elongation YP_002388091.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_002388092.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis YP_002388093.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive YP_002388094.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6396419 YP_002388095.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388096.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388097.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96032391; Product type pm : putative membrane component YP_002388098.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_002388099.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_002388100.1 Essential for efficient processing of 16S rRNA YP_002388101.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_002388103.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins YP_002388104.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388105.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388106.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_002388107.1 catalyzes the phosphorylation of NAD to NADP YP_002388108.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87259985, 91355307, 95058623, 3037486; Product type cp : cell process YP_002388109.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2045357; Product type lp : lipoprotein YP_002388110.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388111.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388112.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_002388113.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15126494, 7737514; Product type pe : putative enzyme YP_002388114.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1718819, 7737514; Product type pe : putative enzyme YP_002388115.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388116.1 Evidence 6 : Doubtful CDS YP_002388117.1 Evidence 6 : Doubtful CDS YP_002388118.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388119.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388120.1 in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution YP_002388121.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate YP_002388122.1 catalyzes the formation of succinate from succinate semialdehyde; NADP dependent YP_002388123.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_002388124.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94127927, 9685361, 8297211; Product type t : transporter YP_002388125.1 regulator of gab gene expression YP_002388126.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388127.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388128.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388129.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : putative enzyme YP_002388130.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20485613, 93126121, 9643551, 98132400, 99415935, 1480493, 7961433; Product type r : regulator YP_002388131.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388132.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7961433 YP_002388133.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388134.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9218434, 11441020, 8820648; Product type pc : putative carrier YP_002388135.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_002388136.1 Catalyzes the rate-limiting step in dNTP synthesis YP_002388137.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_002388138.1 with ProWX is involved in the high-affinity uptake of glycine betaine YP_002388139.1 with ProVX is involved in the high-affinity uptake of glycine betaine YP_002388140.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine YP_002388141.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16000740; Product type pt : putative transporter YP_002388142.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388143.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388144.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB YP_002388145.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 93285984, 94262163, 1409590, 8203018; Product type t : transporter YP_002388146.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 93285984, 94262163, 1409590; Product type t : transporter YP_002388147.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_002388148.1 involved in the first step of glutathione biosynthesis YP_002388149.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388150.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent YP_002388151.1 affects carbohydrate metabolism; has regulatory role in many processes YP_002388152.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002388153.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_002388154.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_002388155.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388156.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan YP_002388157.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87194727, 1334233, 3553176; Product type t : transporter YP_002388158.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1100602, 3553176; Product type t : transporter YP_002388159.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002388160.1 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate YP_002388161.1 regulator for glucitol utilization YP_002388162.1 regulates genes involved in glucitol utilization YP_002388163.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate YP_002388164.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon YP_002388165.1 detoxifies nitric oxide using NADH YP_002388166.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase YP_002388167.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12377778, 92255260, 8661925; Product type e : enzyme YP_002388168.1 involved in electron transport from formate to hydrogen YP_002388169.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88297127, 92334140, 1630307; Product type r : regulator YP_002388170.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002388171.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88297127, 92334140, 1630307; Product type e : enzyme YP_002388172.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388173.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388174.1 involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE YP_002388175.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 92326636, 1625581, 2187144, 7851435; Product type f : factor YP_002388176.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636, 2187144; Product type e : enzyme YP_002388177.1 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate YP_002388178.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 92326636, 94170785, 2187144, 8125094; Product type e : enzyme YP_002388179.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636; Product type m : membrane component YP_002388180.1 catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3) YP_002388181.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636, 2187144; Product type c : carrier YP_002388182.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon YP_002388183.1 plays a role in hydrogenase nickel cofactor insertion YP_002388184.1 GTP hydrolase involved in nickel liganding into hydrogenases YP_002388185.1 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase YP_002388186.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91194542, 92255260, 1849603; Product type f : factor YP_002388187.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91194542, 9485446, 1849603; Product type e : enzyme YP_002388188.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20307603, 21557168, 90368529, 92140045, 94018617, 2118503, 2280686; Product type r : regulator YP_002388189.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388190.1 This protein performs the mismatch recognition step during the DNA repair process YP_002388191.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9130712; Product type e : enzyme YP_002388192.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388193.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388194.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11520622 YP_002388195.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388196.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388197.1 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function YP_002388198.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme YP_002388199.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme YP_002388200.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme YP_002388201.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15731069; Product type r : regulator YP_002388202.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus YP_002388203.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins YP_002388204.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_002388205.1 catalyzes the modification of U13 in tRNA(Glu) YP_002388206.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_002388207.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_002388208.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein YP_002388209.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388210.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis YP_002388211.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ YP_002388212.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_002388213.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3 YP_002388214.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388215.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388216.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388217.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388218.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388219.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388220.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388221.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388222.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type pm : putative membrane component YP_002388223.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_002388224.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide YP_002388225.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity YP_002388226.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123838; Product type e : enzyme YP_002388227.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388228.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002388229.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388230.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002388231.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002388232.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388233.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388234.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388235.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388236.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388239.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388240.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388241.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388242.1 Evidence 6 : Doubtful CDS YP_002388243.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_002388244.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_002388245.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_002388246.1 MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system YP_002388247.1 part of the MazF-MazE toxin-antitoxin system; conteracts MazF YP_002388248.1 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP YP_002388249.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] YP_002388250.1 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system YP_002388251.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20233700, 9772162, 10762278, 13971911; Product type e : enzyme YP_002388252.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9772162; Product type e : enzyme YP_002388253.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10762278; Product type pt : putative transporter YP_002388254.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_002388255.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp YP_002388256.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388257.1 putative SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function YP_002388258.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_002388259.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388260.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8752353, 8026499; Product type pt : putative transporter YP_002388261.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91193203, 93215657, 8385012; Product type e : enzyme YP_002388262.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups YP_002388263.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 89291720, 2553671, 2661535, 2664711, 8385012; Product type e : enzyme YP_002388264.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate YP_002388265.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 90036697, 2553671, 2664711, 7783647; Product type t : transporter YP_002388266.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose YP_002388267.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 90036697, 2664711, 13905785; Product type e : enzyme YP_002388268.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15060078, 12738765, 80049526, 2664711; Product type e : enzyme YP_002388269.1 regulates expression of genes involved in L-fucose utilization YP_002388270.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 21188420, 7704273; Product type pe : putative enzyme YP_002388271.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7704273; Product type pm : putative membrane component YP_002388272.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence YP_002388273.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388274.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15148362, 9278392, 10739946, 10829016; Product type e : enzyme YP_002388275.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002388276.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388277.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_002388279.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12787347, 21348478; Product type e : enzyme YP_002388280.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis YP_002388281.1 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity YP_002388282.1 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity YP_002388283.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91193232, 1570301, 3308636, 3534791, 3537960, 8099278; Product type e : enzyme YP_002388284.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination YP_002388285.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme YP_002388286.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388287.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme YP_002388288.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme YP_002388289.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_002388290.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_002388291.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr YP_002388292.1 hydrolyzes diadenosine polyphosphate YP_002388293.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair YP_002388294.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388295.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388296.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH YP_002388297.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8300626; Product type pm : putative membrane component YP_002388298.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1 YP_002388299.1 controls transcription of galETKM YP_002388300.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding YP_002388301.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase YP_002388302.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15135544; Product type pe : putative enzyme YP_002388303.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7030324, 90239116, 91154204, 2836407, 3543693, 6319708; Product type t : transporter YP_002388304.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate YP_002388305.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate YP_002388306.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_002388307.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388308.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388309.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388310.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388311.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388312.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388313.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002388314.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15150243; Product type pr : putative regulator YP_002388315.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388316.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388317.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12791847 YP_002388318.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12791847; Product type pm : putative membrane component YP_002388319.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12791847; Product type pt : putative transporter YP_002388320.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002388321.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12791847 YP_002388322.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12791847 YP_002388323.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12791847; Product type pm : putative membrane component YP_002388324.1 part of a type III secretory system probably involved in invasion into eukaryotic cells YP_002388325.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388326.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15150243; Product type r : regulator YP_002388327.1 Evidence 6 : Doubtful CDS YP_002388328.1 putative molybdenum cofactor-binding protein; participates in purine salvage YP_002388329.1 FAD-binding subunit; with XdhA and XdhC participates in purine salvage YP_002388330.1 iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage YP_002388331.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388332.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388333.1 catalyzes the formation of pyruvate from 2,3-diaminopropionate YP_002388334.1 Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases YP_002388335.1 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position YP_002388336.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_002388337.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388338.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388339.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388340.1 with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase YP_002388341.1 in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS YP_002388342.1 with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain YP_002388343.1 with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration YP_002388344.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20372655, 98213740; Product type pt : putative transporter YP_002388345.1 Catalyzes the deamination of guanine YP_002388346.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388347.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002388348.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic) YP_002388349.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9098051; Product type t : transporter YP_002388350.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate YP_002388351.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_002388352.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_002388353.1 5'-3' single-stranded-DNA-specific exonuclease YP_002388354.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity YP_002388355.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_002388356.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic YP_002388357.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388358.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388359.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator YP_002388360.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002388361.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388362.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 88297127, 92334140; Product type e : enzyme YP_002388363.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388364.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_002388365.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_002388366.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_002388367.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1339425; Product type pe : putative enzyme YP_002388368.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone YP_002388369.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide YP_002388370.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown YP_002388371.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 412171; Product type cp : cell process YP_002388372.1 Evidence 6 : Doubtful CDS YP_002388373.1 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function YP_002388374.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_002388375.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_002388376.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388377.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_002388378.1 MDM; functions in conversion of succinate to propionate YP_002388379.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins YP_002388380.1 catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA YP_002388381.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20233703; Product type e : enzyme YP_002388382.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388383.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388384.1 Involved in the export of arginine YP_002388385.1 participates in the regulation of osmotic pressure changes within the cel YP_002388386.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_002388387.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_002388388.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate YP_002388389.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388390.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388391.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388392.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388393.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388394.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388395.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388396.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388397.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8353127; Product type t : transporter YP_002388398.1 TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein YP_002388399.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_002388400.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1310091; Product type pe : putative enzyme YP_002388401.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388402.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388403.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme YP_002388404.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388405.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388406.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388407.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388408.1 catalyzes the formation of putrescine from agmatine YP_002388409.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388410.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis YP_002388411.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388412.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388413.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388414.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_002388415.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9182541; Product type t : transporter YP_002388416.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7984428, 8113204 YP_002388417.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 72060411, 92335461, 4955462, 7867949, 8113204; Product type e : enzyme YP_002388418.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_002388419.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_002388420.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388421.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_002388422.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1676385; Product type t : transporter YP_002388423.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388424.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388425.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12975589 YP_002388426.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_002388427.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_002388428.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388429.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis YP_002388430.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153 YP_002388431.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388432.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_002388433.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14730969, 20187555, 20316830, 20580749, 21438845, 90046892, 92409600, 9801309, 2001994, 2197596, 9846876; Product type e : enzyme YP_002388434.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594836, 10493123, 9298646, 9868784; Product type f : factor YP_002388435.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_002388436.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88029453, 90323001, 3311747; Product type t : transporter YP_002388437.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 87260820; Product type e : enzyme YP_002388438.1 Evidence 5 : No homology to any previously reported sequences YP_002388439.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388440.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388441.1 similar to general secretory pathway protein L YP_002388442.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388443.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388444.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388445.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388446.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388447.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter YP_002388448.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter YP_002388449.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter YP_002388450.1 part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm YP_002388451.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388452.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98175453; Product type e : enzyme YP_002388453.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1644747; Product type lp : lipoprotein YP_002388454.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388455.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11785976, 21178909, 11283302; Product type t : transporter YP_002388456.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA YP_002388457.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388458.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type c : carrier YP_002388459.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type e : enzyme YP_002388460.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type e : enzyme YP_002388461.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 9880556, 8606183; Product type r : regulator YP_002388462.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388463.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388464.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388465.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388466.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388467.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388468.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388469.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388470.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002388471.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388472.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388473.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388474.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21336523, 21382172, 7775463; Product type t : transporter YP_002388475.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction YP_002388476.1 YghU; B2989; one of eight putative glutathione transferase proteins from E. coli YP_002388477.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 94292472, 8021226; Product type pf : putative factor YP_002388478.1 plays a role in hydrogenase nickel cofactor insertion YP_002388479.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94292472, 8021226; Product type f : factor YP_002388480.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC) YP_002388481.1 involved in hydrogen uptake YP_002388482.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits YP_002388483.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2 YP_002388484.1 involved in hydrogen uptake YP_002388485.1 Evidence 6 : Doubtful CDS YP_002388486.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388487.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388488.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12583903; Product type e : enzyme YP_002388489.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388490.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388491.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell YP_002388492.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell YP_002388493.1 Evidence 6 : Doubtful CDS YP_002388494.1 catalyzes the formation of L-homocysteine from cystathionine YP_002388495.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388496.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388497.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15327949; Product type e : enzyme YP_002388498.1 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate YP_002388499.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388500.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein YP_002388501.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388502.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88314889, 1557036, 9298646; Product type r : regulator YP_002388503.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92212294, 1557036; Product type e : enzyme YP_002388504.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388505.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002388506.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388507.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9298646 YP_002388508.1 response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes YP_002388509.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21927389; Product type r : regulator YP_002388510.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388511.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96004656, 96217538; Product type c : carrier YP_002388512.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10493123, 9298646, 9600841, 9868784; Product type e : enzyme YP_002388513.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002388514.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate YP_002388515.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96411758; Product type e : enzyme YP_002388516.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388517.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_002388518.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell YP_002388519.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388520.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388521.1 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine YP_002388522.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11790762, 1314093; Product type t : transporter YP_002388523.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388524.1 DHBP synthase; functions during riboflavin biosynthesis YP_002388526.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388527.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002388528.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor YP_002388529.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor YP_002388530.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388531.1 Involved in glycogen synthesis. May be involved in glycogen priming YP_002388532.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388533.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388534.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose YP_002388535.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_002388536.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8412694; Product type pe : putative enzyme YP_002388537.1 Evidence 6 : Doubtful CDS YP_002388538.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11274153; Product type pr : putative regulator YP_002388539.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases YP_002388540.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_002388541.1 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin YP_002388542.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_002388543.1 activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol YP_002388544.1 Involved in the tartrate degradation pathway YP_002388545.1 Involved in the tartrate degradation pathway YP_002388546.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388547.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_002388548.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_002388549.1 synthesizes RNA primers at the replication forks YP_002388550.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_002388551.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20412902, 99453007, 6269063, 7567469, 8878487, 9489705; Product type e : enzyme YP_002388552.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002388553.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388554.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20015410, 9380671, 9643537, 9190831; Product type r : regulator YP_002388555.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate YP_002388556.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11101501 YP_002388557.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89128452, 2515108, 3939708; Product type r : regulator YP_002388558.1 in Escherichia coli this is the second beta-galactosidase system YP_002388559.1 in Escherichia coli this is the second beta-galactosidase system YP_002388560.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388561.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388562.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15213393; Product type pe : putative enzyme YP_002388563.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12840019, 89380266; Product type e : enzyme YP_002388564.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388565.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388566.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388567.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002388568.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388569.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12107143, 2108134; Product type pm : putative membrane component YP_002388570.1 involved in the import of serine and threonine coupled with the import of sodium YP_002388571.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388572.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4570160, 83114543, 3038546; Product type e : enzyme YP_002388573.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism YP_002388574.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83218546, 98190790; Product type t : transporter YP_002388575.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388576.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388577.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002388578.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002388579.1 regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization. YP_002388580.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388581.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153 YP_002388582.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388583.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388584.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388585.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388586.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388587.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8478329; Product type e : enzyme YP_002388588.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388589.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388590.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388591.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388592.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388594.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388595.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388596.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98143432, 9484901; Product type e : enzyme YP_002388597.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12777779, 9484901; Product type e : enzyme YP_002388598.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98143432, 9484901; Product type e : enzyme YP_002388599.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism YP_002388600.1 involved in the import of threonine and serine in combination with the import of a proton YP_002388601.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic YP_002388602.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation YP_002388603.1 participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon YP_002388604.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388605.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1705543, 2573820, 2660107, 6351058 YP_002388606.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388607.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20225875, 69151449, 9772162; Product type e : enzyme YP_002388608.1 catalyzes the reduction of tartronate semialdehyde to glycerate YP_002388609.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate YP_002388610.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10762278, 9772162; Product type pt : putative transporter YP_002388611.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20225875, 66096392, 81027430, 9772162, 10762278, 2407727; Product type e : enzyme YP_002388612.1 SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation YP_002388613.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388614.1 transcriptional repressor for the agaZVWA and agaSYBCDI operons YP_002388615.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976750, 20392444, 10931310, 8932697; Product type e : enzyme YP_002388616.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport YP_002388617.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388618.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388619.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388620.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme YP_002388621.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689210, 9697096, 14731281, 8932697; Product type e : enzyme YP_002388622.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway YP_002388623.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport YP_002388624.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport YP_002388625.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport YP_002388626.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10931310; Product type e : enzyme YP_002388627.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002388628.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11677609; Product type f : factor YP_002388629.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002388630.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002388631.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388632.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388633.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388634.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein YP_002388635.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153 YP_002388636.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388637.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388638.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388639.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388640.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388641.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388642.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002388643.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10206698; Product type e : enzyme YP_002388644.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10206698; Product type e : enzyme YP_002388645.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388646.1 tryptophan transporter of high affinity YP_002388647.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division YP_002388648.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing YP_002388649.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87083499, 91198209, 99234021, 99340204, 2432069, 3005122, 6382163, 9008164, 9298646; Product type e : enzyme YP_002388650.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_002388651.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_002388652.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_002388653.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_002388654.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_002388655.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_002388656.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis YP_002388657.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388658.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20194819, 21125563, 9020118, 94074540, 9564033, 9644254, 9829959, 99298179, 7556084, 8034620, 8045257, 8244950, 8253068; Product type t : transporter YP_002388659.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_002388660.1 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate YP_002388661.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins YP_002388662.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit YP_002388663.1 RNA binding protein found associated to pre-50S subunit of the ribosome; putative role in ribosome assembly; necessary for optimal growth but not cell viability YP_002388664.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_002388665.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_002388666.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_002388667.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388668.1 involved in the peptidyltransferase reaction during translation YP_002388669.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91088242, 94146411, 10094780, 387076, 8312607; Product type s : structure YP_002388670.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94311902, 97284515, 2670911, 8037730, 8312607; Product type e : enzyme YP_002388671.1 activator of maltose metabolism genes YP_002388672.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_002388673.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388674.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388675.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter YP_002388676.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter YP_002388677.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter YP_002388678.1 ATP-binding subunit of a putative ABC toluene efflux transporter YP_002388679.1 YrbG; inner membrane protein involved in cell envelope integrity; putative sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers YP_002388680.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12805358; Product type e : enzyme YP_002388681.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis YP_002388682.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388683.1 LptA; periplasmic binding protein part of a putative ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system YP_002388684.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7876255, 9298646, 17056748; Product type pt : putative transporter YP_002388685.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen YP_002388686.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing YP_002388687.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88212176, 90136533, 90274974, 95020584, 95181483, 7876255, 8025669, 8444818, 9636714; Product type t : transporter YP_002388688.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388689.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10473571, 95181483, 7876255, 8025669; Product type t : transporter YP_002388690.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 89083480 YP_002388691.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan YP_002388692.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92246944, 98269038, 1575737, 9603997; Product type pe : putative enzyme YP_002388693.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA YP_002388694.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388695.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate YP_002388696.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_002388697.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388698.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388699.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein YP_002388700.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_002388701.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96011396, 9864311, 7592358; Product type t : transporter YP_002388702.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid YP_002388703.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization YP_002388704.1 YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic YP_002388705.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12445774, 94293773, 1721886, 3029697, 8022275; Product type f : factor YP_002388706.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation YP_002388707.1 forms a direct contact with the tRNA during translation YP_002388708.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_002388709.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388710.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16079137; Product type pe : putative enzyme YP_002388711.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8830688, 96165272, 8576051, 8576052, 9740056; Product type e : enzyme YP_002388712.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15137941, 15225661, 21352996, 96165272, 99431977, 3322223, 8576051; Product type e : enzyme YP_002388713.1 oxidizes malate to oxaloacetate YP_002388714.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_002388715.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388716.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388717.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate YP_002388718.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate YP_002388719.1 membrane protein AaeX; the gene is a member of the aaeXAB operon YP_002388720.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15489430; Product type r : regulator YP_002388721.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA YP_002388722.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10960106; Product type pm : putative membrane component YP_002388723.1 involved in the processing of the 5'end of 16S rRNA YP_002388724.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_002388725.1 part of cell wall structural complex MreBCD; transmembrane component YP_002388726.1 Evidence 6 : Doubtful CDS YP_002388727.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_002388728.1 functions in MreBCD complex in some organisms YP_002388729.1 Evidence 6 : Doubtful CDS YP_002388730.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules YP_002388731.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388732.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_002388733.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_002388734.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388735.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase YP_002388736.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_002388737.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566, 1459953, 1547773, 2835774, 2837762, 8226664; Product type e : enzyme YP_002388738.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription YP_002388739.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15028690, 9073062; Product type e : enzyme YP_002388740.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388741.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8203018, 11257026, 8407802, 1720861; Product type r : regulator YP_002388742.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012493, 1720861; Product type lp : lipoprotein YP_002388743.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94262163, 99449638, 1720861, 8407802; Product type t : transporter YP_002388744.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388745.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388746.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter YP_002388747.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter YP_002388748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter YP_002388749.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8809753, 8898392; Product type t : transporter YP_002388750.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388751.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388752.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_002388753.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA YP_002388754.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388755.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8432722 YP_002388756.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8112305, 8432722 YP_002388757.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_002388758.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_002388759.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase YP_002388760.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_002388761.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_002388762.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388763.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators YP_002388764.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388765.1 is a component of the macrolide binding site in the peptidyl transferase center YP_002388766.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_002388767.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_002388768.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_002388769.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_002388770.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_002388771.1 late assembly protein YP_002388772.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_002388773.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_002388774.1 binds 5S rRNA along with protein L5 and L25 YP_002388775.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_002388776.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_002388777.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_002388778.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_002388779.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_002388780.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_002388781.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_002388782.1 one of the stabilizing components for the large ribosomal subunit YP_002388783.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_002388784.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_002388785.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_002388786.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_002388787.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_002388788.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_002388789.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_002388790.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_002388791.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_002388792.1 Evidence 6 : Doubtful CDS YP_002388793.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002388794.1 iron storage protein YP_002388795.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8954950, 9889981, 2661540, 8639572; Product type c : carrier YP_002388796.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_002388797.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_002388798.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_002388799.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_002388800.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_002388801.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_002388802.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_002388803.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388804.1 rotamase YP_002388805.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388806.1 rotamase YP_002388807.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388808.1 involved in potassium efflux YP_002388809.1 required for KefB activity YP_002388810.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388811.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9889164; Product type pe : putative enzyme YP_002388812.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388813.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2559876; Product type e : enzyme YP_002388814.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388815.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388816.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons YP_002388817.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388818.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate YP_002388819.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity YP_002388820.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92021789, 94095125, 2007139, 2403545, 2546924, 7549107; Product type cp : cell process YP_002388821.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388822.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90272647, 91175755, 1606970, 2001362, 2007139, 2190212, 2403545, 2546924, 8130188, 8180197; Product type e : enzyme YP_002388823.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20509826; Product type pt : putative transporter YP_002388824.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93062014, 2200672, 2445993, 2543955; Product type e : enzyme YP_002388825.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations YP_002388826.1 member of the FNT family of formate and nitrite transporters YP_002388827.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin YP_002388828.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388829.1 inner membrane protein possibly involved in fructoselysine transport; member of the flr operon YP_002388830.1 catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine YP_002388831.1 YhfOP; YhfP; YhfO; FrlC; catalyzes the interconversion of fructoselysine and psicoselysine YP_002388832.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12147680; Product type e : enzyme YP_002388833.1 may act as a transcriptional regulator of a putative fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes YP_002388834.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388835.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388836.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388837.1 phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE) YP_002388838.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388839.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388840.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388841.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388842.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002388843.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_002388844.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_002388845.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90136529, 92262475, 92272672, 2549371, 6300769, 7603433, 8341592; Product type e : enzyme YP_002388846.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388847.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_002388848.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_002388849.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa YP_002388850.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388851.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388852.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure YP_002388853.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor YP_002388854.1 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits YP_002388855.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_002388856.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11553591; Product type r : regulator YP_002388857.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388858.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9867837, 10675343, 10675344; Product type f : factor YP_002388859.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_002388860.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 20223645; Product type pm : putative membrane component YP_002388861.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388862.1 Evidence 6 : Doubtful CDS YP_002388863.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_002388864.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388865.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2404279; Product type pr : putative regulator YP_002388866.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR YP_002388867.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation YP_002388868.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_002388869.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8755871; Product type f : factor YP_002388870.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012482, 8407793; Product type t : transporter YP_002388871.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake YP_002388872.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388873.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2678009; Product type ph : phenotype YP_002388874.1 Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis YP_002388875.1 involved in high-affinity gluconate transport YP_002388876.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source YP_002388877.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 4574689, 4582156, 93139975, 97141270, 98019089, 2845225, 3040894, 7984428, 9045817; Product type t : transporter YP_002388878.1 amylomaltase; acts to release glucose from maltodextrins YP_002388879.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89033892, 10220320, 10469642, 2845225, 3037809, 3155826, 6283313, 6339728, 6986282, 9009262; Product type e : enzyme YP_002388880.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides YP_002388881.1 catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester YP_002388882.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9738023 YP_002388883.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9738023, 3045764, 7920643, 7984428; Product type r : regulator YP_002388884.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism YP_002388885.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity YP_002388886.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine YP_002388887.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane YP_002388888.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388889.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388890.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388891.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388892.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88330897, 91104907, 91236706, 2645169, 2975249, 3047129, 3097003; Product type e : enzyme YP_002388893.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_002388894.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_002388895.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen YP_002388896.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_002388897.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_002388898.1 YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP) YP_002388899.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8655507, 9119199, 9135111, 97141270; Product type t : transporter YP_002388900.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate YP_002388901.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 9135111, 93139975, 9537375, 8655507; Product type r : regulator YP_002388902.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388903.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10493123; Product type pe : putative enzyme YP_002388904.1 YhhY; regulated by the fur regulator; unknown function YP_002388905.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388906.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388907.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388908.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388909.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides YP_002388910.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388911.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate YP_002388912.1 part of the UgpABCE glycerol-3-phosphate uptake system YP_002388913.1 with UgpABC is involved in uptake of glycerol-3-phosphate YP_002388914.1 with UgpEC is involved in the uptake of glycerol-3-phosphate YP_002388915.1 with UgpACE is involved in the uptake of glycerol-3-phosphate YP_002388916.1 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_002388917.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_002388918.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_002388919.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter YP_002388920.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702302, 90307651, 2195019, 2649683, 3891753, 4077929, 9298646, 9298646; Product type t : transporter YP_002388921.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388922.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388923.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388924.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702302, 90307651, 2195019, 2649682, 328304, 3891753, 4077929, 9298646, 10972807; Product type t : transporter YP_002388925.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_002388926.1 putative ABC transporter, membrane protein YP_002388927.1 putative ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions YP_002388928.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins YP_002388929.1 catalyzes the methylation of 16S rRNA at position G966 YP_002388930.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388931.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388932.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388933.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury YP_002388934.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs YP_002388935.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388936.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12558182, 8752353; Product type t : transporter YP_002388937.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388938.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388939.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20092861, 10625633, 8939709; Product type e : enzyme YP_002388940.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12960164, 7934931, 92077434, 7867647; Product type t : transporter YP_002388941.1 with NikACDE is involved in nickel transport into the cell YP_002388942.1 with NikABDE is involved in nickel transport into the cell YP_002388943.1 with NikABCE is involved in nickel transport into the cell YP_002388944.1 with NikABCD is involved with nickel transport into the cell YP_002388945.1 Inhibits transcription at high concentrations of nickel YP_002388946.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388947.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388948.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20074572; Product type e : enzyme YP_002388949.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388950.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388951.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388952.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388953.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002388954.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87014120; Product type t : transporter YP_002388955.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress YP_002388956.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 93086426, 93308072, 94203056, 10499297, 10652104, 10931298, 11157932, 1453957, 8506346, 8932299, 9298646, 9405142; Product type f : factor YP_002388957.1 member of the POT family of peptide transporters; probable proton-dependent peptide transporter function YP_002388958.1 predicted SAM-dependent methyltransferase YP_002388959.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92394891, 1325967, 8366062; Product type e : enzyme YP_002388960.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11591672; Product type pe : putative enzyme YP_002388961.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_002388962.1 Evidence 6 : Doubtful CDS YP_002388963.1 regulates the expression of of the arsRBC involved in resistance to arsenic YP_002388964.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15004242, 95355341, 1535622, 7721697; Product type t : transporter YP_002388965.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95355341, 7721697; Product type e : enzyme YP_002388966.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388967.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002388968.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002388969.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293775, 8022277; Product type lp : lipoprotein YP_002388970.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8022277; Product type pr : putative regulator YP_002388971.1 inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli YP_002388972.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94064579, 8885264, 12071744, 8244952, 8455549, 9298646, 9868784; Product type pf : putative factor YP_002388973.1 inactive form YP_002388974.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94064579, 8244952, 8455549; Product type pm : putative membrane component YP_002388975.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12399493, 12940989, 14702398; Product type r : regulator YP_002388976.1 with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds YP_002388977.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803; Product type t : transporter YP_002388978.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12446650; Product type r : regulator YP_002388979.1 regulates genes in response to acid and/or during stationary phase YP_002388980.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92155241, 92394884, 99406302, 1522060, 1740158, 7764225, 9298646; Product type e : enzyme YP_002388981.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8163487, 14563563; Product type e : enzyme YP_002388982.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose YP_002388983.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388984.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002388985.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002388986.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002388987.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002388988.1 in Escherichia coli this protein is involved in flagellar function YP_002388989.1 Evidence 6 : Doubtful CDS YP_002388990.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4359651, 13813474; Product type e : enzyme YP_002388991.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pe : putative enzyme YP_002388992.1 involved in the transport of C4-dicarboxylates across the membrane YP_002388993.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a putative phosphodiesterase protein from E. coli YP_002388994.1 cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA YP_002388995.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans YP_002388996.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP) YP_002388997.1 polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis YP_002388999.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389000.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929533, 11260463; Product type pe : putative enzyme YP_002389001.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389002.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929533, 11260463; Product type pe : putative enzyme YP_002389003.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123448; Product type f : factor YP_002389004.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123448; Product type f : factor YP_002389005.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389006.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15901718; Product type t : transporter YP_002389007.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides YP_002389008.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF YP_002389009.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7536291; Product type t : transporter YP_002389010.1 transports peptides consisting of two or three amino acids YP_002389011.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389012.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100289, 92065799, 1702779, 1956284, 7536291, 8527431, 8563629, 9298646, 9600841, 9740056, 10972807; Product type t : transporter YP_002389013.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389014.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide YP_002389015.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type pm : putative membrane component YP_002389016.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component YP_002389017.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component YP_002389018.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component YP_002389019.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component YP_002389020.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002389021.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389022.1 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine YP_002389023.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11237876; Product type pe : putative enzyme YP_002389024.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82119950, 90202748, 2180922, 374979; Product type e : enzyme YP_002389025.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component YP_002389026.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15801772, 11237876, 99030322, 99357626, 9298646, 9811658; Product type e : enzyme YP_002389027.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389028.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002389029.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389030.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20345064, 90115858, 94293754, 94293756, 99177178, 10696873, 1597410, 1961761, 2404279, 7515185, 8197194, 9405743, 9439003, 9692981; Product type f : factor YP_002389031.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002389032.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002389033.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389034.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389035.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389036.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6320721; Product type pm : putative membrane component YP_002389037.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6330500, 92366447, 95050816, 6320721; Product type e : enzyme YP_002389038.1 catalyzes the interconversion of D-xylose to D-xylulose YP_002389039.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity YP_002389040.1 with XylFH is part of the high affinity xylose ABC transporter YP_002389041.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94316500; Product type t : transporter YP_002389042.1 Evidence 6 : Doubtful CDS YP_002389043.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6330500, 94316500; Product type r : regulator YP_002389044.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1544897 YP_002389045.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds YP_002389046.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis YP_002389047.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002389048.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 20372646, 9826648; Product type r : regulator YP_002389049.1 NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate YP_002389050.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21617392 YP_002389051.1 membrane-spanning protein involved in uptake of 2,3-diketo-L-gulonate; part of the tri-partite ATP-independent periplasmic transport system (TRAP) YiaMNO YP_002389052.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14668138, 21617392; Product type t : transporter YP_002389053.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14668138, 21617392; Product type t : transporter YP_002389054.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21617392, 95050816, 7961955; Product type e : enzyme YP_002389055.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate YP_002389056.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate YP_002389057.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_002389058.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389059.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002389060.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15668009; Product type t : transporter YP_002389061.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389062.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389063.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95286498, 7768815; Product type e : enzyme YP_002389064.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2935393; Product type e : enzyme YP_002389065.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264431, 91317715, 9315303, 94148228, 2140572, 2531290; Product type f : factor YP_002389066.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis YP_002389067.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8387990; Product type pe : putative enzyme YP_002389068.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389069.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389071.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389072.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389073.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389074.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92052139, 92283796, 94131964, 1946374, 3135464, 3142516, 6309813, 9551558; Product type t : transporter YP_002389075.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90254197, 1964486, 3135464, 6384188, 8300537, 13295236; Product type e : enzyme YP_002389076.1 Acts as a repressor of the mtlAD operon YP_002389077.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389078.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389079.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389080.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389081.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012541, 11283302, 11785976, 8407843; Product type t : transporter YP_002389082.1 represses the lctPRD operon YP_002389083.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration YP_002389084.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates YP_002389085.1 catalyzes the O-acetylation of serine YP_002389086.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_002389087.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_002389088.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94316500, 95024051, 99175138, 11031118, 7937896, 8636094, 9973569; Product type c : carrier YP_002389089.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389090.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_002389091.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12113939, 21972773; Product type cp : cell process YP_002389092.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389093.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15659689, 2647748; Product type pe : putative enzyme YP_002389094.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism YP_002389095.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_002389096.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose YP_002389097.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core YP_002389098.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20507564, 92250420, 93239678, 9446588, 1624462, 8478319; Product type e : enzyme YP_002389099.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92250420, 92325067, 93054344, 1624462; Product type e : enzyme YP_002389100.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389101.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9791168, 9756860, 9792656; Product type e : enzyme YP_002389102.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92250420, 92325067, 9756860; Product type e : enzyme YP_002389103.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9791168, 9756860, 9792656; Product type e : enzyme YP_002389104.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme YP_002389105.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101922, 92121133, 92210496, 9756860, 1732225; Product type e : enzyme YP_002389106.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92121133, 92210496, 92250420, 1447141, 1732225, 7988890; Product type e : enzyme YP_002389107.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9756860, 1447141, 1732225; Product type e : enzyme YP_002389108.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A YP_002389109.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_002389110.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_002389111.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_002389112.1 required for 70S ribosome assembly YP_002389113.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389114.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_002389115.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_002389116.1 catalyzes the formation of dUMP from dUTP YP_002389117.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly YP_002389118.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_002389119.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_002389120.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389121.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type cp : cell process YP_002389122.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389123.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+ YP_002389124.1 Essential for recycling GMP and indirectly, cGMP YP_002389125.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_002389126.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12224635, 89255395, 93266525, 94068533, 2005134, 2549050; Product type e : enzyme YP_002389127.1 specifically modifies tRNA at position G18 YP_002389128.1 catalyzes branch migration in Holliday junction intermediates YP_002389129.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389130.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91203811, 93106943, 1544582, 2017136, 2254324; Product type t : transporter YP_002389131.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002389132.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389133.1 catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides YP_002389134.1 may be involved in the transport of galactosides-pentoses-hexuronides YP_002389135.1 Evidence 6 : Doubtful CDS YP_002389136.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10438463, 10209755; Product type pt : putative transporter YP_002389137.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389138.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88298691, 89359178, 9914480, 3003106; Product type lp : lipoprotein YP_002389139.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389140.1 experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS YP_002389141.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389142.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002389143.1 catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type YP_002389144.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate YP_002389145.1 membrane protein regulates uhpT expression YP_002389146.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph YP_002389147.1 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter YP_002389148.1 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit YP_002389149.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2989782, 85242083, 92380929, 2989781; Product type e : enzyme YP_002389151.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide YP_002389152.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389153.1 Evidence 6 : Doubtful CDS YP_002389154.1 multidrug efflux protein involved in adaptation to low energy shock YP_002389155.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002389156.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389157.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389158.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389159.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389160.1 uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function YP_002389161.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002389162.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002389163.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002389164.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1356969; Product type pt : putative transporter YP_002389165.1 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent YP_002389166.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress YP_002389167.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389168.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389169.1 FAD/NAD(P)-binding domain YP_002389170.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type t : transporter YP_002389171.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type e : enzyme YP_002389172.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism YP_002389173.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type e : enzyme YP_002389174.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 79020349; Product type pr : putative regulator YP_002389175.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein YP_002389176.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins YP_002389177.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389178.1 negatively supercoils closed circular double-stranded DNA YP_002389179.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_002389180.1 binds the polymerase to DNA and acts as a sliding clamp YP_002389181.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_002389183.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_002389184.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_002389185.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389186.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_002389187.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_002389188.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide YP_002389189.1 tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan YP_002389190.1 tryptophan transporter of low affinity YP_002389191.1 Confers resistance to chloramphenicol YP_002389192.1 Involved in anaerobic NO protection YP_002389193.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389194.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14766567; Product type e : enzyme YP_002389195.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389196.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily YP_002389197.1 might be involved in hypersensitivity to nitrofurzone YP_002389198.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389199.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389200.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389201.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10027967; Product type t : transporter YP_002389202.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 88297127, 92334140, 3034860, 3309161; Product type e : enzyme YP_002389203.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002389204.1 positive regulator of the beta-glucoside operon; transcriptional antiterminator YP_002389205.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon YP_002389206.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_002389207.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_002389208.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_002389209.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90133909, 2215649, 6321434, 6365894, 9228942, 9298646, 9671506; Product type t : transporter YP_002389210.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12438351, 7721701, 16128397; Product type ps : putative structure YP_002389211.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7721701, 16128397; Product type pt : putative transporter YP_002389212.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16128397, 12438351; Product type pc : putative carrier YP_002389213.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16125910, 12438351; Product type ps : putative structure YP_002389214.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_002389215.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_002389216.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_002389217.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_002389218.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_002389219.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_002389220.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_002389221.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_002389222.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_002389223.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_002389224.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation YP_002389225.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_002389226.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_002389227.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_002389228.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase YP_002389229.1 catalyzes the formation of asparagine from aspartate and ammonia YP_002389230.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA YP_002389231.1 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase YP_002389232.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH YP_002389233.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source YP_002389234.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain YP_002389235.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B YP_002389236.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system YP_002389237.1 catalyzes the formation of D-ribose 5-phosphate from ribose YP_002389238.1 DNA-binding transcriptional repressor of ribose metabolism YP_002389239.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 20218988, 12107133; Product type t : transporter YP_002389240.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002389241.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon YP_002389242.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389243.1 among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function YP_002389244.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87174741; Product type l : leader peptide YP_002389245.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit YP_002389246.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92332418, 92380929, 1569580, 3550695, 3897211; Product type e : enzyme YP_002389247.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_002389248.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_002389249.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway YP_002389250.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate YP_002389251.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_002389252.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94215709, 7878732, 7925971, 8163020; Product type e : enzyme YP_002389253.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389254.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication YP_002389255.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation YP_002389256.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation YP_002389257.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202710, 91154193, 92250497, 99175138, 10489448, 1094461, 10947986, 1561103, 2181145, 2193685, 3891733, 4616096, 4883076, 6098320, 6099324, 7812718, 8098620, 8253691; Product type c : carrier YP_002389258.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide YP_002389259.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_002389260.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389261.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92114763, 94245613, 94292435, 10629198, 11024259, 11700352, 11832520, 1722555, 1730666; Product type e : enzyme YP_002389262.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein YP_002389263.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90212314, 90337949, 92112804, 94042873, 11106477, 7559340, 8170390, 8226648; Product type e : enzyme YP_002389264.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid YP_002389265.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88086930, 90212314, 90337949, 92112804, 92174908, 94018634, 94042873, 7559340; Product type e : enzyme YP_002389266.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94292435, 96032389; Product type e : enzyme YP_002389267.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90212314, 90337949, 92112804, 8366065; Product type e : enzyme YP_002389268.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis YP_002389269.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12621029, 20044778; Product type t : transporter YP_002389270.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis YP_002389271.1 enterobacterial common antigen polymerase YP_002389272.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88086874, 90337949, 92112804; Product type e : enzyme YP_002389273.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function YP_002389274.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11222759, 2180918, 12419807, 14749327; Product type pr : putative regulator YP_002389275.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 89041586; Product type pe : putative enzyme YP_002389276.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 89098348, 92358234, 3054815, 3062586, 9298646; Product type pe : putative enzyme YP_002389277.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis YP_002389278.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_002389279.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP YP_002389280.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly YP_002389281.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389282.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389283.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389284.1 Evidence 6 : Doubtful CDS YP_002389285.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein YP_002389286.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_002389287.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389288.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_002389289.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function YP_002389290.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. YP_002389291.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389292.1 responsible for the influx of magnesium ions YP_002389293.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389294.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389295.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389296.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389297.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389298.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002389299.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389300.1 catalyzes the hydrolysis of phosphatidylcholine YP_002389301.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway YP_002389302.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99313167, 10386596, 3027506; Product type t : transporter YP_002389303.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99313167, 10386596; Product type t : transporter YP_002389305.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates YP_002389306.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium YP_002389307.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389308.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90384950, 96303520, 2205852, 2643109; Product type r : regulator YP_002389309.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_002389310.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12676709; Product type pe : putative enzyme YP_002389311.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway YP_002389312.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner YP_002389313.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_002389314.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389315.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions YP_002389316.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_002389317.1 mediates the export of protein precursors bearing twin-arginine signal peptides YP_002389318.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane YP_002389319.1 magnesium dependent; not involved in the Sec-independent protein export system YP_002389320.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92011415, 92250420, 92261317, 1584020, 12007406; Product type r : regulator YP_002389321.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol YP_002389322.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin YP_002389323.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_002389324.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_002389325.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters YP_002389326.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15103642; Product type pf : putative factor YP_002389327.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100357, 2243799, 7896723; Product type t : transporter YP_002389328.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX YP_002389329.1 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway YP_002389330.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_002389331.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389332.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages YP_002389333.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12498799, 93264419, 94016574, 94206930, 99298180, 10210188, 1429594, 1740115, 1934062, 8413591, 8494885, 8521518, 9194175, 9298646, 9300489, 9572841, 9600841, 9655827; Product type e : enzyme YP_002389334.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389335.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389336.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_002389337.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389338.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_002389339.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389340.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_002389341.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54 YP_002389342.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation YP_002389343.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme YP_002389344.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389345.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9642082, 7783627, 9298646, 9622352; Product type f : factor YP_002389346.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002389347.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389348.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002389349.1 porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown YP_002389350.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002389351.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002389352.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15294295; Product type e : enzyme YP_002389353.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389354.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389355.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389356.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389357.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389358.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002389359.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389360.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease YP_002389361.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_002389362.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389363.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389364.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389365.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389366.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002389367.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389368.1 required for the formation of active formate dehydrogenase YP_002389369.1 cytochrome b556(FDO) component; heme containing YP_002389370.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91317715, 8522521, 9852007; Product type c : carrier YP_002389371.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme YP_002389372.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_002389373.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389374.1 putative repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system YP_002389375.1 with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars YP_002389376.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 94290319; Product type t : transporter YP_002389377.1 with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system YP_002389378.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15060078; Product type e : enzyme YP_002389379.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90128204, 93374854, 8396120; Product type e : enzyme YP_002389380.1 catalyzes the formation of L-rhamnulose from L-rhamnose YP_002389381.1 catalyzes the ATP-dependent phosphorylation of rhamnulose YP_002389382.1 activates the expression of the rhaBAD operon and rhaT gene YP_002389383.1 activates the expression of rhaRS in response to L-rhamnose YP_002389384.1 transports L-rhamnose and L-lyxose into the cell YP_002389385.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals YP_002389386.1 transports degraded pectin products into the bacterial cell YP_002389387.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389388.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors YP_002389389.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system YP_002389390.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates YP_002389391.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers YP_002389392.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_002389393.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91161616, 2002055, 3158524, 8774726, 9298646; Product type t : transporter YP_002389394.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86008270, 2995360, 3158524; Product type e : enzyme YP_002389395.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_002389396.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389397.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389398.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389399.1 with UspC and Usp E is involved in resistance to UV radiation YP_002389400.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93194782, 94092163, 95050480, 95362685, 1400248, 2834327, 7961651, 8449868, 9149148; Product type e : enzyme YP_002389401.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_002389402.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_002389403.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12629974, 12948772, 14646142, 15004242, 90094250, 92210584, 11039922, 11101882, 11226336, 11964478, 1372899, 2544860, 6998951; Product type t : transporter YP_002389404.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389405.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_002389406.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_002389407.1 heat shock protein involved in degradation of misfolded proteins YP_002389408.1 heat shock protein involved in degradation of misfolded proteins YP_002389409.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9282742, 93285993, 8509333; Product type cp : cell process YP_002389410.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins YP_002389411.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_002389412.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_002389413.1 member of the NlpC/P60 superfamily of peptidases YP_002389414.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis YP_002389415.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine YP_002389416.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_002389417.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor YP_002389418.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90292022, 94209230, 3045098; Product type e : enzyme YP_002389419.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002389420.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389421.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone YP_002389422.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies YP_002389423.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 95291446, 7773398; Product type t : transporter YP_002389424.1 FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site YP_002389425.1 FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS YP_002389426.1 involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein YP_002389427.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95291446, 14673546, 7773398; Product type e : enzyme YP_002389428.1 FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog YP_002389429.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002389430.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10456927; Product type pm : putative membrane component YP_002389431.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_002389432.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis YP_002389433.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_002389434.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_002389435.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_002389436.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 93341455, 94310441; Product type pe : putative enzyme YP_002389437.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002389438.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA YP_002389439.1 catalyzes the conversion of NADPH to NADH YP_002389440.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis YP_002389441.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389442.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs YP_002389443.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space YP_002389444.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_002389445.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_002389446.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon YP_002389447.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_002389448.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_002389449.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_002389450.1 Modulates Rho-dependent transcription termination YP_002389451.1 binds directly to 23S ribosomal RNA YP_002389452.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_002389453.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_002389454.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_002389455.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_002389456.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_002389457.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264341, 92021792, 2160943; Product type f : factor YP_002389458.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center YP_002389459.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_002389460.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate YP_002389461.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8432721, 94089392, 98298179, 10082377, 9632726; Product type e : enzyme YP_002389462.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate YP_002389463.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_002389464.1 binds specifically to the major sigma factor sigma 70; active in stationary phase YP_002389465.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates YP_002389466.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_002389467.1 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures YP_002389468.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389469.1 histone-like DNA-binding protein YP_002389470.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389471.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98362023, 9694902; Product type pf : putative factor YP_002389472.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21140164, 89327164, 92255260, 11243806, 2666400; Product type r : regulator YP_002389473.1 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein YP_002389474.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_002389475.1 involved in de novo purine biosynthesis YP_002389476.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme YP_002389477.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis YP_002389478.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle YP_002389479.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91295197, 92112731, 92353108, 2836370, 3049537, 3060852, 3276689, 3290857, 3291954, 7826335; Product type e : enzyme YP_002389480.1 Evidence 6 : Doubtful CDS YP_002389481.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol YP_002389482.1 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase YP_002389483.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity YP_002389484.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002389485.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family YP_002389486.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA YP_002389487.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389488.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389489.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389490.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor YP_002389491.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive YP_002389492.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_002389493.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389494.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein YP_002389495.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389496.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002389497.1 Evidence 6 : Doubtful CDS YP_002389498.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389499.1 Evidence 6 : Doubtful CDS YP_002389500.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10986267; Product type pm : putative membrane component YP_002389501.1 xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter YP_002389502.1 with MalKFE is involved in the transport of maltose into the cell YP_002389503.1 with MalKGE is involved in maltose transport into the cell YP_002389504.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis YP_002389505.1 with malEFG is involved in import of maltose/maltodextrin YP_002389506.1 porin involved in the transport of maltose and maltodextrins YP_002389507.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87141162, 2434655, 6086106; Product type pt : putative transporter YP_002389508.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389509.1 in E. coli, some yjbl mutations have been reported as suppressors of dnaG mutations YP_002389510.1 catalyzes the formation of 4-hydroxybenzoate from chorismate YP_002389511.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway YP_002389512.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_002389513.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10220339, 6257698, 86278195, 88111690, 2984194, 6309817, 8071224; Product type e : enzyme YP_002389514.1 Represses a number of genes involved in the response to DNA damage YP_002389515.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87165788; Product type cp : cell process YP_002389516.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential YP_002389517.1 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB YP_002389518.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389519.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389520.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566; Product type e : enzyme YP_002389521.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia YP_002389522.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94089392, 7602590; Product type e : enzyme YP_002389523.1 unwinds double stranded DNA YP_002389524.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_002389525.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_002389526.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389527.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity YP_002389528.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11972052 YP_002389529.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389530.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_002389531.1 binds to single stranded DNA and PriA helcase facilitate replication restart YP_002389532.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389533.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002389534.1 regulates genes involved in response to oxidative stress YP_002389535.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91210176, 91360349, 94139656, 9564045, 10207625, 12670967, 1653416, 1708380, 7673113, 8065907, 8306957, 8631739, 8969171, 9019397, 9092651, 9204707; Product type r : regulator YP_002389536.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002389537.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 21557160, 11479290; Product type pt : putative transporter YP_002389538.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389539.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake YP_002389540.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14563880; Product type pm : putative membrane component YP_002389541.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_002389542.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552 YP_002389543.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia YP_002389544.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94335626, 8057835; Product type c : carrier YP_002389545.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 8057835; Product type e : enzyme YP_002389546.1 with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552 YP_002389547.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 9593308, 8057835, 8842153; Product type f : factor YP_002389548.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 9593308, 8057835, 8842153; Product type f : factor YP_002389549.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system YP_002389550.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389551.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme YP_002389552.1 part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family YP_002389553.1 possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride YP_002389554.1 with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride YP_002389555.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389556.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1587481; Product type pe : putative enzyme YP_002389557.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389558.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389559.1 required for the use of phosphonates and phosphite as phosphorus sources YP_002389560.1 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role YP_002389561.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12700258, 91100346, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme YP_002389562.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100346, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme YP_002389563.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme YP_002389564.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme YP_002389565.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme YP_002389566.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme YP_002389567.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme YP_002389568.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme YP_002389569.1 may be involved in phosphonate uptake and biodegradation YP_002389570.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter YP_002389571.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type t : transporter YP_002389572.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type t : transporter YP_002389573.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 93328121, 9650256, 2155230 YP_002389574.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 93328121, 9650256, 2155230 YP_002389575.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389576.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389577.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10049386, 12525168, 92165733, 93132799, 9871325, 99376621, 8421314; Product type t : transporter YP_002389578.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94110256, 8282725; Product type r : regulator YP_002389579.1 response regulator in two-component regulatory system with BasS YP_002389580.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division YP_002389581.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12867448; Product type t : transporter YP_002389582.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : c; Product type r : regulator YP_002389583.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93186686, 2830169, 4204273, 8383109; Product type e : enzyme YP_002389584.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90060832, 9108148, 1445207, 2684786, 2830169; Product type r : regulator YP_002389585.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87174747, 88162811, 90248411, 2831880, 3031590, 6329200; Product type e : enzyme YP_002389586.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14757226, 90241878, 92297631, 93155159, 1730719, 1872836, 6323466, 8672452; Product type t : transporter YP_002389587.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389588.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86142617, 88193096, 89255123, 2656658; Product type e : enzyme YP_002389589.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters YP_002389590.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration YP_002389591.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration YP_002389592.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389593.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389594.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389595.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389596.1 class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_002389597.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002389598.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92105022, 92210511, 1370290, 1556085, 4204273; Product type e : enzyme YP_002389599.1 antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein YP_002389600.1 regulates the cadBA operon YP_002389601.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389602.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1370290; Product type pr : putative regulator YP_002389603.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm YP_002389604.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals YP_002389605.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB YP_002389606.1 catalyzes the formation of fumarate from aspartate YP_002389607.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein YP_002389608.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function YP_002389609.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_002389610.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_002389611.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389612.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389613.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme YP_002389614.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389615.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019591, 10629195; Product type pe : putative enzyme YP_002389616.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_002389617.1 acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex YP_002389618.1 Evidence 6 : Doubtful CDS YP_002389619.1 member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations YP_002389620.1 lipocalin; globomycin-sensitive outer membrane lipoprotein YP_002389621.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92212899, 97464439, 99421326, 10595535, 6795623, 7041115, 9819201; Product type e : enzyme YP_002389622.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane YP_002389623.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_002389624.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_002389625.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_002389626.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002389627.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002389628.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002389629.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine YP_002389630.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_002389631.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_002389632.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier YP_002389633.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389634.1 possibly involved in cell wall synthesis YP_002389635.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21348478, 87242501, 1594459, 7511774; Product type e : enzyme YP_002389636.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_002389637.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_002389638.1 Stimulates the elongation of poly(A) tails YP_002389639.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein YP_002389640.1 with HflC inhibits proteolysis of lambda cII protein by FtsH YP_002389641.1 with HflK inhibits proteolysis of lambda cII protein by FtsH YP_002389642.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389643.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_002389644.1 negatively regulates the transcription of genes upregulated by nitrosative stress YP_002389645.1 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs YP_002389646.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA YP_002389647.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389648.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002389649.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389650.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389651.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389652.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389653.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA YP_002389654.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389655.1 in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility YP_002389656.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo YP_002389657.1 negative regulator of ulaG and ulaABCDEF YP_002389658.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12644495, 15808744; Product type pe : putative enzyme YP_002389659.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_002389660.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_002389661.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_002389662.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization YP_002389663.1 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway YP_002389664.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_002389665.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389666.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_002389667.1 binds single-stranded DNA at the primosome assembly site YP_002389668.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_002389669.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_002389670.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389671.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme YP_002389672.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389673.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8559074; Product type ps : putative structure YP_002389674.1 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides YP_002389675.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine YP_002389676.1 Involved in anaerobic NO protection and iron metabolism YP_002389677.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389678.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14747727; Product type e : enzyme YP_002389679.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20088838; Product type pr : putative regulator YP_002389680.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate YP_002389681.1 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate YP_002389682.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pr : putative regulator YP_002389683.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389684.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389685.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_002389686.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389687.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389688.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389689.1 part of the toxin-antitoxin ChpB-ChpS system YP_002389690.1 toxin of the ChpB-ChpS toxin-antitoxin system YP_002389691.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_002389692.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pt : putative transporter YP_002389693.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002389694.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002389695.1 membrane component of a putative sugar ABC transporter system YP_002389696.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_002389697.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96404780, 2843822, 7984428, 8808921; Product type e : enzyme YP_002389698.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389699.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD YP_002389700.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1761034, 8499452, 10393541; Product type c : carrier YP_002389701.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions YP_002389702.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_002389703.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264345, 93302496, 8083158, 8421692; Product type e : enzyme YP_002389704.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002389705.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon YP_002389706.1 P-type ATPase involved in magnesium influx YP_002389707.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12515541, 10493123, 10595546, 9298646; Product type pe : putative enzyme YP_002389708.1 involved in the allosteric regulation of aspartate carbamoyltransferase YP_002389709.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_002389710.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide YP_002389711.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389712.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389713.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002389714.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11115104 YP_002389715.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III. YP_002389716.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389717.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389718.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389719.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_002389720.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_002389721.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_002389722.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389723.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389724.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389725.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12147722; Product type pe : putative enzyme YP_002389726.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389727.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2403440; Product type h : extrachromosomal origin YP_002389728.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10671450; Product type pe : putative enzyme YP_002389729.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10671450; Product type pe : putative enzyme YP_002389730.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389731.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002389732.1 Evidence 5 : No homology to any previously reported sequences YP_002389733.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002389734.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin YP_002389735.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389736.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389737.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389738.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389739.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389740.1 Evidence 5 : No homology to any previously reported sequences YP_002389741.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389743.1 Evidence 5 : No homology to any previously reported sequences YP_002389744.1 Evidence 5 : No homology to any previously reported sequences YP_002389745.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389746.1 Evidence 6 : Doubtful CDS YP_002389747.1 Evidence 5 : No homology to any previously reported sequences YP_002389748.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389749.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389750.1 Evidence 5 : No homology to any previously reported sequences YP_002389751.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389752.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389753.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15743943; Product type t : transporter YP_002389754.1 Evidence 6 : Doubtful CDS YP_002389755.1 Evidence 6 : Doubtful CDS YP_002389756.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389757.1 inversion of on/off regulator of fimA YP_002389758.1 inversion of on/off regulator of fimA YP_002389759.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6146599, 6147250, 90220509, 93106965, 2858471, 6123483; Product type s : structure YP_002389760.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12897022, 11673421, 6147250; Product type s : structure YP_002389761.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20450729, 90220509, 93155127, 93391362, 1363735, 8104335, 8636962, 9783748; Product type f : factor YP_002389762.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12842468, 90220509, 1970114; Product type f : factor YP_002389763.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 92394896, 1970114, 2890081; Product type s : structure YP_002389764.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 92394896, 2890081; Product type s : structure YP_002389765.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 93155127, 93391362, 1971261, 2890081, 2900235; Product type s : structure YP_002389766.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96125229, 15516583, 8550444; Product type t : transporter YP_002389767.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate YP_002389768.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73203083, 77222076, 14401695; Product type e : enzyme YP_002389769.1 regulates the expression of uxuBA YP_002389770.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389771.1 Evidence 6 : Doubtful CDS YP_002389772.1 inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS YP_002389773.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002389774.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95181377, 7876157; Product type e : enzyme YP_002389775.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389776.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389777.1 in yeast cells this enzyme removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate; functions in tRNA splicing; the function and substrate of bacterial enzymes in organisms that do not perform splicing is unknown YP_002389778.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389779.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389780.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389781.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8365476, 7607244, 15654892; Product type e : enzyme YP_002389782.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3691501, 11106419; Product type pe : putative enzyme YP_002389783.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389784.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803; Product type t : transporter YP_002389785.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389786.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002389788.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389789.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1472713, 15128530, 9292993; Product type e : enzyme YP_002389790.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14696199; Product type pe : putative enzyme YP_002389791.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389792.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389793.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389794.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8077235, 8550403, 10633095; Product type e : enzyme YP_002389795.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8077235, 8550403, 10653707; Product type e : enzyme YP_002389796.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8077235, 8550403; Product type r : regulator YP_002389797.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8550403, 14744977; Product type pt : putative transporter YP_002389798.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8529896, 8550403; Product type e : enzyme YP_002389799.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8550403, 9492273; Product type e : enzyme YP_002389800.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2194841; Product type e : enzyme YP_002389801.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8550403; Product type e : enzyme YP_002389802.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7737515, 2061311, 8550403; Product type e : enzyme YP_002389803.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8223600, 8384293, 11863436; Product type e : enzyme YP_002389804.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8384293, 8550403; Product type r : regulator YP_002389805.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20015410, 89034150, 91317710, 10466731, 2033064, 6213619, 6402709, 8384293; Product type r : regulator YP_002389806.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter YP_002389807.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002389808.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389809.1 catalyzes the transfer of phosphoglycerol to the glucan backbone YP_002389810.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389811.1 acts to load the DnaB helicase onto the initiation site during DNA replication YP_002389812.1 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' YP_002389813.2 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389814.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component YP_002389815.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator YP_002389816.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin YP_002389817.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11931550, 14756576, 3323834, 9990318; Product type c : carrier YP_002389818.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389819.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit YP_002389820.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_002389821.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18 YP_002389822.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily YP_002389823.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_002389824.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1317380, 8253679, 9298646, 9600841; Product type cp : cell process YP_002389825.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389826.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389827.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389828.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme YP_002389829.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389830.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_002389831.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate YP_002389832.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_002389833.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_002389834.1 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins YP_002389835.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2684780 YP_002389836.1 catalyzes the formation of serine from O-phosphoserine YP_002389837.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_002389838.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide YP_002389839.1 Evidence 4 : Homologs of previously reported genes of unknown function YP_002389840.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_002389841.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan YP_002389842.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription YP_002389843.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme YP_002389844.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog YP_002389845.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate YP_002389846.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20264525, 20309711, 93194823, 96405618, 8449900; Product type r : regulator YP_002389847.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3531171, 8449900 YP_002389848.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation YP_002389849.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation YP_002389850.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88216172, 2835585, 2984198, 3531171; Product type m : membrane component YP_002389851.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15028693, 21167794, 21317451, 91008980, 91358353, 92380937, 9514749, 9632255, 2984198, 7565118, 9298646; Product type r : regulator YP_002389852.1 member of the SPOUT superfamily of methyltransferases