-- dump date 20140619_082317 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 585034000001 SEQ_END SEQ_END NC_011741.1 4700560 4700560 DR NC_011741.1; contig end 4700560..4700560 Escherichia coli IAI1 YP_002385499.1 CDS thrL NC_011741.1 190 255 D involved in threonine biosynthesis; controls the expression of the thrLABC operon; thr operon leader peptide 190..255 Escherichia coli IAI1 7125488 YP_002385500.1 CDS thrA NC_011741.1 336 2798 D multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 336..2798 Escherichia coli IAI1 7126255 YP_002385501.1 CDS thrB NC_011741.1 2800 3732 D catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 2800..3732 Escherichia coli IAI1 7126252 YP_002385502.1 CDS thrC NC_011741.1 3733 5019 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 3733..5019 Escherichia coli IAI1 7126253 YP_002385503.1 CDS yaaX NC_011741.1 5233 5529 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5233..5529 Escherichia coli IAI1 7126254 YP_002385504.1 CDS yaaA NC_011741.1 5682 6458 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5682..6458) Escherichia coli IAI1 7126489 YP_002385505.1 CDS yaaJ NC_011741.1 6528 7958 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino acid sodium/proton transporter complement(6528..7958) Escherichia coli IAI1 7126484 YP_002385506.1 CDS talB NC_011741.1 8237 9190 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8332529, 92334977, 11298760, 7592346, 8805555, 9007983, 9298646; Product type e : enzyme; transaldolase B 8237..9190 Escherichia coli IAI1 7126487 YP_002385507.1 CDS mogA NC_011741.1 9305 9892 D forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 9305..9892 Escherichia coli IAI1 7126209 YP_002385508.1 CDS yaaH NC_011741.1 9927 10493 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(9927..10493) Escherichia coli IAI1 7124304 YP_002385509.1 CDS htpY NC_011741.1 10642 11355 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8478327; Product type r : regulator; hypothetical protein complement(10642..11355) Escherichia coli IAI1 7126485 YP_002385510.1 CDS yaaI NC_011741.1 11381 11785 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(11381..11785) Escherichia coli IAI1 7125320 YP_002385511.1 CDS dnaK NC_011741.1 12162 14078 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 12162..14078 Escherichia coli IAI1 7126486 YP_002385512.1 CDS dnaJ NC_011741.1 14167 15297 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 14167..15297 Escherichia coli IAI1 7127476 YP_002385513.1 CDS mokC NC_011741.1 15401 15610 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90136075, 92048480, 92048481, 99291074; Product type r : regulator; regulatory protein for HokC, overlaps CDS of hokC complement(15401..15610) Escherichia coli IAI1 7124609 YP_002385514.1 CDS nhaA NC_011741.1 16139 17305 D exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 16139..17305 Escherichia coli IAI1 7127947 YP_002385515.1 CDS nhaR NC_011741.1 17365 18270 D Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 17365..18270 Escherichia coli IAI1 7127873 YP_002385516.1 CDS ECIAI1_0019 NC_011741.1 18309 19268 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(18309..19268) Escherichia coli IAI1 7127875 YP_002385517.1 CDS ECIAI1_0020 NC_011741.1 19281 19592 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(19281..19592) Escherichia coli IAI1 7126970 YP_002385518.1 CDS ECIAI1_0021 NC_011741.1 20175 20426 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(20175..20426) Escherichia coli IAI1 7126971 YP_002385519.1 CDS ECIAI1_0022 NC_011741.1 20859 22280 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(20859..22280) Escherichia coli IAI1 7126972 YP_002385520.1 CDS rpsT NC_011741.1 22764 23027 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(22764..23027) Escherichia coli IAI1 7126973 YP_002385521.1 CDS yaaY NC_011741.1 23130 23348 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 23130..23348 Escherichia coli IAI1 7128426 YP_002385522.1 CDS ribF NC_011741.1 23356 24297 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 23356..24297 Escherichia coli IAI1 7126490 YP_002385523.1 CDS ileS NC_011741.1 24340 27156 D IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 24340..27156 Escherichia coli IAI1 7124997 YP_002385524.1 CDS lspA NC_011741.1 27156 27650 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 27156..27650 Escherichia coli IAI1 7126049 YP_002385525.1 CDS fkpB NC_011741.1 27738 28187 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97332650, 2011499; Product type e : enzyme; FKBP-type peptidyl-prolyl cis-trans isomerase 27738..28187 Escherichia coli IAI1 7127632 YP_002385526.1 CDS ispH NC_011741.1 28189 29139 D catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 28189..29139 Escherichia coli IAI1 7127208 YP_002385527.1 CDS rihC NC_011741.1 29205 30119 D catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 29205..30119 Escherichia coli IAI1 7126085 YP_002385528.1 CDS dapB NC_011741.1 30286 31107 D catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 30286..31107 Escherichia coli IAI1 7125000 YP_002385529.1 CDS carA NC_011741.1 31563 32711 D catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 31563..32711 Escherichia coli IAI1 7126917 YP_002385530.1 CDS carB NC_011741.1 32729 35950 D four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 32729..35950 Escherichia coli IAI1 7124448 YP_002385531.1 CDS ECIAI1_0035 NC_011741.1 35958 36176 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7815937, 6308632; hypothetical protein complement(35958..36176) Escherichia coli IAI1 7124449 YP_002385532.1 CDS caiF NC_011741.1 36211 36606 D regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; DNA-binding transcriptional activator CaiF 36211..36606 Escherichia coli IAI1 7126974 YP_002385533.1 CDS caiE NC_011741.1 36692 37282 R involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE complement(36692..37282) Escherichia coli IAI1 7124445 YP_002385534.2 CDS caiD NC_011741.1 37288 38073 R catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase complement(37288..38073) Escherichia coli IAI1 7124444 YP_002385535.1 CDS caiC NC_011741.1 38182 39750 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15731894, 97189569, 7815937; Product type e : enzyme; putative crotonobetaine/carnitine-CoA ligase complement(38182..39750) Escherichia coli IAI1 7124443 YP_002385536.1 CDS caiB NC_011741.1 39809 41026 R catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine; crotonobetainyl-CoA:carnitine CoA-transferase complement(39809..41026) Escherichia coli IAI1 7124442 YP_002385537.1 CDS caiA NC_011741.1 41155 42297 R catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase complement(41155..42297) Escherichia coli IAI1 7124441 YP_002385538.1 CDS caiT NC_011741.1 42328 43842 R catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter complement(42328..43842) Escherichia coli IAI1 7124440 YP_002385539.1 CDS fixA NC_011741.1 44316 45086 D required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; putative electron transfer flavoprotein FixA 44316..45086 Escherichia coli IAI1 7124446 YP_002385540.1 CDS fixB NC_011741.1 45101 46042 D involved in electron transfer during carnitine metabolism; putative electron transfer flavoprotein FixB 45101..46042 Escherichia coli IAI1 7127122 YP_002385541.1 CDS fixC NC_011741.1 46093 47379 D FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; putative oxidoreductase FixC 46093..47379 Escherichia coli IAI1 7127123 YP_002385542.1 CDS fixX NC_011741.1 47376 47663 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96066354, 12081978; Product type pc : putative carrier; putative 4Fe-4S ferredoxin 47376..47663 Escherichia coli IAI1 7127124 YP_002385543.1 CDS yaaU NC_011741.1 47721 49052 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 47721..49052 Escherichia coli IAI1 7127125 YP_002385544.1 CDS kefF NC_011741.1 49160 49690 D Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 49160..49690 Escherichia coli IAI1 7126488 YP_002385545.1 CDS kefC NC_011741.1 49683 51545 D transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 49683..51545 Escherichia coli IAI1 7126388 YP_002385546.1 CDS folA NC_011741.1 51737 52216 D catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 51737..52216 Escherichia coli IAI1 7126387 YP_002385547.1 CDS apaH NC_011741.1 52294 53136 R hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase complement(52294..53136) Escherichia coli IAI1 7127259 YP_002385548.1 CDS apaG NC_011741.1 53143 53520 R protein associated with Co2+ and Mg2+ efflux; ApaG protein complement(53143..53520) Escherichia coli IAI1 7125768 YP_002385549.1 CDS ksgA NC_011741.1 53523 54344 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(53523..54344) Escherichia coli IAI1 7125767 YP_002385550.1 CDS pdxA NC_011741.1 54341 55330 R catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase complement(54341..55330) Escherichia coli IAI1 7126392 YP_002385551.1 CDS surA NC_011741.1 55330 56616 R Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA complement(55330..56616) Escherichia coli IAI1 7124163 YP_002385552.1 CDS imp NC_011741.1 56669 59023 R determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein complement(56669..59023) Escherichia coli IAI1 7126202 YP_002385553.1 CDS djlA NC_011741.1 59278 60093 D functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 59278..60093 Escherichia coli IAI1 7126062 YP_002385554.1 CDS rluA NC_011741.1 60210 60869 R catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A complement(60210..60869) Escherichia coli IAI1 7124593 YP_002385555.1 CDS hepA NC_011741.1 60881 63787 R transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA complement(60881..63787) Escherichia coli IAI1 7125009 YP_002385556.1 CDS polB NC_011741.1 63952 66303 R Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II complement(63952..66303) Escherichia coli IAI1 7128517 YP_002385557.1 CDS araD NC_011741.1 66378 67073 R catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase complement(66378..67073) Escherichia coli IAI1 7126112 YP_002385558.1 CDS araA NC_011741.1 67242 68744 R catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase complement(67242..68744) Escherichia coli IAI1 7125778 YP_002385559.1 CDS araB NC_011741.1 68755 70455 R catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase complement(68755..70455) Escherichia coli IAI1 7125775 YP_002385560.1 CDS araC NC_011741.1 70794 71672 D positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; DNA-binding transcriptional regulator AraC 70794..71672 Escherichia coli IAI1 7125776 YP_002385561.1 CDS yabI NC_011741.1 71758 72522 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 71758..72522 Escherichia coli IAI1 7125777 YP_002385562.1 CDS thiQ NC_011741.1 72636 73334 R with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding subunit complement(72636..73334) Escherichia coli IAI1 7126491 YP_002385563.1 CDS thiP NC_011741.1 73318 74928 R permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein complement(73318..74928) Escherichia coli IAI1 7126250 YP_002385564.1 CDS tbpA NC_011741.1 74904 75887 R part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit complement(74904..75887) Escherichia coli IAI1 7126249 YP_002385565.1 CDS sgrR NC_011741.1 76051 77706 R activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR complement(76051..77706) Escherichia coli IAI1 7125492 YP_002385566.1 CDS ECIAI1_0070 NC_011741.1 77627 77926 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 77627..77926 Escherichia coli IAI1 7127926 YP_002385567.1 CDS setA NC_011741.1 78028 79206 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438463, 10209755; Product type t : transporter; broad specificity sugar efflux system 78028..79206 Escherichia coli IAI1 7127927 YP_002385568.1 CDS leuD NC_011741.1 79255 79860 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(79255..79860) Escherichia coli IAI1 7127912 YP_002385569.1 CDS leuC NC_011741.1 79871 81271 R dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit complement(79871..81271) Escherichia coli IAI1 7126410 YP_002385570.1 CDS leuB NC_011741.1 81274 82365 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(81274..82365) Escherichia coli IAI1 7126409 YP_002385571.1 CDS leuA NC_011741.1 82365 83936 R catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase complement(82365..83936) Escherichia coli IAI1 7126408 YP_002385572.1 CDS leuL NC_011741.1 84029 84115 R involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide complement(84029..84115) Escherichia coli IAI1 7125499 YP_002385573.1 CDS leuO NC_011741.1 84775 85719 D activator for leuABCD operon; member of LysR family of transcriptional activators; leucine transcriptional activator 84775..85719 Escherichia coli IAI1 7126411 YP_002385574.1 CDS ilvI NC_011741.1 86037 87761 D catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 86037..87761 Escherichia coli IAI1 7126412 YP_002385575.1 CDS ilvH NC_011741.1 87764 88255 D with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 87764..88255 Escherichia coli IAI1 7126057 YP_002385576.1 CDS fruR NC_011741.1 88435 89439 D binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 88435..89439 Escherichia coli IAI1 7126056 YP_002385577.1 CDS mraZ NC_011741.1 90041 90499 D MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 90041..90499 Escherichia coli IAI1 7128220 YP_002385578.1 CDS mraW NC_011741.1 90501 91442 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20042184, 10493123, 2187182, 6350821; Product type e : enzyme; S-adenosyl-methyltransferase MraW 90501..91442 Escherichia coli IAI1 7124469 YP_002385579.1 CDS ftsL NC_011741.1 91439 91804 D membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 91439..91804 Escherichia coli IAI1 7124467 YP_002385580.1 CDS ftsI NC_011741.1 91820 93586 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91072213, 92202178, 94095121, 9603865, 9614966, 1332942, 1447153, 2198024, 2677607, 2681146, 3049550, 3911028, 6350821; Product type e : enzyme; septal peptidoglycan synthesis transpeptidase 91820..93586 Escherichia coli IAI1 7128238 YP_002385581.1 CDS murE NC_011741.1 93573 95060 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 93573..95060 Escherichia coli IAI1 7128236 YP_002385582.1 CDS murF NC_011741.1 95057 96415 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88273095, 90248455, 91310568, 97128642, 11090285, 2668880, 9166795; Product type e : enzyme; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 95057..96415 Escherichia coli IAI1 7124496 YP_002385583.1 CDS mraY NC_011741.1 96409 97491 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 96409..97491 Escherichia coli IAI1 7124497 YP_002385584.1 CDS murD NC_011741.1 97494 98810 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 97494..98810 Escherichia coli IAI1 7124468 YP_002385585.1 CDS ftsW NC_011741.1 98810 100054 D integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 98810..100054 Escherichia coli IAI1 7124495 YP_002385586.1 CDS murG NC_011741.1 100051 101118 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 100051..101118 Escherichia coli IAI1 7128241 YP_002385587.1 CDS murC NC_011741.1 101172 102647 D Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 101172..102647 Escherichia coli IAI1 7124498 YP_002385588.1 CDS ddl NC_011741.1 102640 103560 D D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 102640..103560 Escherichia coli IAI1 7124494 YP_002385589.1 CDS ftsQ NC_011741.1 103562 104392 D involved in septum formation; cell division protein FtsQ 103562..104392 Escherichia coli IAI1 7124549 YP_002385590.1 CDS ftsA NC_011741.1 104389 105651 D ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 104389..105651 Escherichia coli IAI1 7128240 YP_002385591.1 CDS ftsZ NC_011741.1 105712 106863 D GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 105712..106863 Escherichia coli IAI1 7128232 YP_002385592.1 CDS lpxC NC_011741.1 106964 107881 D zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 106964..107881 Escherichia coli IAI1 7128244 YP_002385593.1 CDS secM NC_011741.1 108112 108624 D secM translational pause allows for the initiation of secA translation; SecA regulator SecM 108112..108624 Escherichia coli IAI1 7127624 YP_002385594.1 CDS secA NC_011741.1 108686 111391 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 108686..111391 Escherichia coli IAI1 7124697 YP_002385595.1 CDS mutT NC_011741.1 111451 111840 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10218109, 89264540, 90136514, 91225007, 97444511, 1309939, 2841285, 3033442, 3288626, 7578113, 9063868; Product type e : enzyme; nucleoside triphosphate pyrophosphohydrolase 111451..111840 Escherichia coli IAI1 7124691 YP_002385596.1 CDS yacF NC_011741.1 112147 112890 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(112147..112890) Escherichia coli IAI1 7124506 YP_002385597.1 CDS coaE NC_011741.1 112890 113510 R catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase complement(112890..113510) Escherichia coli IAI1 7126493 YP_002385598.1 CDS guaC NC_011741.1 113735 114778 D catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 113735..114778 Escherichia coli IAI1 7126344 YP_002385599.1 CDS hofC NC_011741.1 114813 116015 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96099298, 2904262, 7959070; Product type s : structure; type IV pilin biogenesis protein complement(114813..116015) Escherichia coli IAI1 7128478 YP_002385600.1 CDS hofB NC_011741.1 116005 117390 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96099298, 7959070; Product type pt : putative transporter; hypothetical protein complement(116005..117390) Escherichia coli IAI1 7125288 YP_002385601.1 CDS ppdD NC_011741.1 117400 117840 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20100782, 20271862, 96099298, 7959070; Product type ps : putative structure; putative major pilin subunit complement(117400..117840) Escherichia coli IAI1 7125287 YP_002385602.1 CDS nadC NC_011741.1 118043 118936 R catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase complement(118043..118936) Escherichia coli IAI1 7126129 YP_002385603.1 CDS ampD NC_011741.1 119024 119575 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90113890, 95047240, 2607970, 7959070; Product type e : enzyme; N-acetyl-anhydromuranmyl-L-alanine amidase 119024..119575 Escherichia coli IAI1 7124513 YP_002385604.1 CDS ampE NC_011741.1 119572 120426 D involved in regulation of beta-lactamase; putative signaling protein; regulatory protein AmpE 119572..120426 Escherichia coli IAI1 7125757 YP_002385605.1 CDS aroP NC_011741.1 120469 121842 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1104763, 90174991, 9150230; Product type t : transporter; aromatic amino acid transporter complement(120469..121842) Escherichia coli IAI1 7125758 YP_002385606.1 CDS pdhR NC_011741.1 122383 123147 D activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 122383..123147 Escherichia coli IAI1 7125813 YP_002385607.1 CDS ECIAI1_0111 NC_011741.1 123144 123326 R Evidence 6 : Doubtful CDS; hypothetical protein complement(123144..123326) Escherichia coli IAI1 7127474 YP_002385608.1 CDS aceE NC_011741.1 123308 125971 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 123308..125971 Escherichia coli IAI1 7126976 YP_002385609.1 CDS aceF NC_011741.1 125986 127878 D E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 125986..127878 Escherichia coli IAI1 7125696 YP_002385610.1 CDS lpd NC_011741.1 128203 129627 D E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 128203..129627 Escherichia coli IAI1 7125697 YP_002385611.1 CDS yacH NC_011741.1 129698 131455 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(129698..131455) Escherichia coli IAI1 7126440 YP_002385612.1 CDS acnB NC_011741.1 131810 134407 D catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 131810..134407 Escherichia coli IAI1 7126494 YP_002385613.1 CDS yacL NC_011741.1 134583 134945 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2666401, 7567469; hypothetical protein 134583..134945 Escherichia coli IAI1 7125701 YP_002385614.1 CDS speD NC_011741.1 134983 135777 R S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase complement(134983..135777) Escherichia coli IAI1 7126495 YP_002385615.1 CDS speE NC_011741.1 135793 136659 R catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase complement(135793..136659) Escherichia coli IAI1 7127957 YP_002385616.1 CDS yacC NC_011741.1 136765 137283 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2666401; hypothetical protein complement(136765..137283) Escherichia coli IAI1 7127958 YP_002385617.1 CDS cueO NC_011741.1 137278 138828 D laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 137278..138828 Escherichia coli IAI1 7126492 YP_002385618.1 CDS gcd NC_011741.1 139030 141420 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10359647, 11604400, 14612441, 91035240, 93123180, 93286127; Product type e : enzyme; glucose dehydrogenase complement(139030..141420) Escherichia coli IAI1 7126857 YP_002385619.1 CDS hpt NC_011741.1 141626 142162 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 13808016, 339828, 6787390, 6801015, 12070315; Product type e : enzyme; hypoxanthine phosphoribosyltransferase 141626..142162 Escherichia coli IAI1 7128291 YP_002385620.1 CDS can NC_011741.1 142203 142865 R catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase complement(142203..142865) Escherichia coli IAI1 7125306 YP_002385621.1 CDS yadG NC_011741.1 142974 143900 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 142974..143900 Escherichia coli IAI1 7124447 YP_002385622.1 CDS yadH NC_011741.1 143897 144667 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10474187; Product type pt : putative transporter; putative ABC transporter membrane protein 143897..144667 Escherichia coli IAI1 7126499 YP_002385623.1 CDS yadI NC_011741.1 144772 145212 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative PTS Enzyme IIA 144772..145212 Escherichia coli IAI1 7126500 YP_002385624.1 CDS yadE NC_011741.1 145276 146505 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported polysaccharide deacetylase 145276..146505 Escherichia coli IAI1 7126501 YP_002385625.1 CDS panD NC_011741.1 146509 146889 R Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase complement(146509..146889) Escherichia coli IAI1 7126498 YP_002385626.1 CDS yadD NC_011741.1 147163 148065 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11319082; Product type pe : putative enzyme; putative transposase 147163..148065 Escherichia coli IAI1 7124152 YP_002385627.1 CDS panC NC_011741.1 148139 148990 R catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase complement(148139..148990) Escherichia coli IAI1 7126497 YP_002385628.1 CDS panB NC_011741.1 149002 149796 R catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase complement(149002..149796) Escherichia coli IAI1 7124151 YP_002385629.1 CDS ECIAI1_0133 NC_011741.1 149909 151255 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8096212; Product type ps : putative structure; putative fimbrial-like adhesin protein complement(149909..151255) Escherichia coli IAI1 7124150 YP_002385630.1 CDS yadK NC_011741.1 151236 151832 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein complement(151236..151832) Escherichia coli IAI1 7126977 YP_002385631.1 CDS yadL NC_011741.1 151859 152461 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein complement(151859..152461) Escherichia coli IAI1 7126502 YP_002385632.1 CDS yadM NC_011741.1 152476 153045 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein complement(152476..153045) Escherichia coli IAI1 7126503 YP_002385633.1 CDS htrE NC_011741.1 153062 155662 R similar to the fimbrial usher protein PapC; putative outer membrane usher protein complement(153062..155662) Escherichia coli IAI1 7126504 YP_002385634.1 CDS ecpD NC_011741.1 155697 156437 R Evidence 2b : Function of strongly homologous gene; PubMedId : 93352405, 8102362, 15561151; Product type f : factor; putative chaperone protein EcpD complement(155697..156437) Escherichia coli IAI1 7125322 YP_002385635.1 CDS yadN NC_011741.1 156542 157126 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein complement(156542..157126) Escherichia coli IAI1 7125047 YP_002385636.1 CDS folK NC_011741.1 157496 157975 R catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase complement(157496..157975) Escherichia coli IAI1 7126505 YP_002385637.1 CDS pcnB NC_011741.1 157972 159390 R Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase I complement(157972..159390) Escherichia coli IAI1 7127264 YP_002385638.1 CDS yadB NC_011741.1 159429 160355 R this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase complement(159429..160355) Escherichia coli IAI1 7124161 YP_002385639.1 CDS dksA NC_011741.1 160392 160847 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15294157, 90202727, 2013578, 9298646, 9600841; Product type r : regulator; RNA polymerase-binding transcription factor complement(160392..160847) Escherichia coli IAI1 7126496 YP_002385640.1 CDS sfsA NC_011741.1 161025 161729 R Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A complement(161025..161729) Escherichia coli IAI1 7124598 YP_002385641.1 CDS ligT NC_011741.1 161744 162274 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97094878; Product type e : enzyme; 2'-5' RNA ligase complement(161744..162274) Escherichia coli IAI1 7127921 YP_002385642.1 CDS hrpB NC_011741.1 162348 164777 D similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 162348..164777 Escherichia coli IAI1 7126420 YP_002385643.1 CDS mrcB NC_011741.1 164973 167507 D bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 164973..167507 Escherichia coli IAI1 7125308 YP_002385644.1 CDS fhuA NC_011741.1 167727 169970 D involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 167727..169970 Escherichia coli IAI1 7124471 YP_002385645.1 CDS fhuC NC_011741.1 170021 170818 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding subunit 170021..170818 Escherichia coli IAI1 7127098 YP_002385646.1 CDS fhuD NC_011741.1 170818 171708 D Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 170818..171708 Escherichia coli IAI1 7127100 YP_002385647.1 CDS fhuB NC_011741.1 171705 173687 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 171705..173687 Escherichia coli IAI1 7127101 YP_002385648.1 CDS hemL NC_011741.1 173722 175002 R Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase complement(173722..175002) Escherichia coli IAI1 7127099 YP_002385649.1 CDS clcA NC_011741.1 175227 176648 D Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 175227..176648 Escherichia coli IAI1 7128513 YP_002385650.1 CDS yadR NC_011741.1 176730 177074 D essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 176730..177074 Escherichia coli IAI1 7126329 YP_002385651.1 CDS yadS NC_011741.1 177121 177744 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(177121..177744) Escherichia coli IAI1 7126506 YP_002385652.1 CDS btuF NC_011741.1 177782 178582 R solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF complement(177782..178582) Escherichia coli IAI1 7126507 YP_002385653.1 CDS pfs NC_011741.1 178575 179273 R enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase complement(178575..179273) Escherichia coli IAI1 7124427 YP_002385654.1 CDS dgt NC_011741.1 179357 180874 D forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 179357..180874 Escherichia coli IAI1 7124184 YP_002385655.1 CDS degP NC_011741.1 181004 182428 D protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 181004..182428 Escherichia coli IAI1 7124578 YP_002385656.1 CDS cdaR NC_011741.1 182583 183740 D regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization; carbohydrate diacid transcriptional activator CdaR 182583..183740 Escherichia coli IAI1 7124560 YP_002385657.1 CDS yaeH NC_011741.1 183829 184215 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(183829..184215) Escherichia coli IAI1 7126294 YP_002385658.1 CDS dapD NC_011741.1 184530 185354 R catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase complement(184530..185354) Escherichia coli IAI1 7126511 YP_002385659.1 CDS glnD NC_011741.1 185385 188057 R catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase complement(185385..188057) Escherichia coli IAI1 7126918 YP_002385660.1 CDS map NC_011741.1 188119 188913 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase complement(188119..188913) Escherichia coli IAI1 7128323 YP_002385661.1 CDS ECIAI1_0166 NC_011741.1 188913 189134 R Evidence 6 : Doubtful CDS; hypothetical protein complement(188913..189134) Escherichia coli IAI1 7127672 YP_002385662.1 CDS rpsB NC_011741.1 189281 190006 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 189281..190006 Escherichia coli IAI1 7126205 YP_002385663.1 CDS tsf NC_011741.1 190264 191115 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 190264..191115 Escherichia coli IAI1 7128408 YP_002385664.1 CDS pyrH NC_011741.1 191262 191987 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 191262..191987 Escherichia coli IAI1 7127509 YP_002385665.1 CDS frr NC_011741.1 192279 192836 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 192279..192836 Escherichia coli IAI1 7126575 YP_002385666.1 CDS dxr NC_011741.1 192928 194124 D catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 192928..194124 Escherichia coli IAI1 7127284 YP_002385667.1 CDS ispU NC_011741.1 194310 195071 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 194310..195071 Escherichia coli IAI1 7125035 YP_002385668.1 CDS ECIAI1_0173 NC_011741.1 195071 195223 D hypothetical protein 195071..195223 Escherichia coli IAI1 7126086 YP_002385669.1 CDS cdsA NC_011741.1 195084 195941 D catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 195084..195941 Escherichia coli IAI1 7126979 YP_002385670.1 CDS yaeL NC_011741.1 195953 197305 D catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 195953..197305 Escherichia coli IAI1 7126297 YP_002385671.1 CDS yaeT NC_011741.1 197335 199767 D part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 197335..199767 Escherichia coli IAI1 7126513 YP_002385672.1 CDS hlpA NC_011741.1 199889 200374 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15101556, 90201355, 97032152, 99386928, 1987124, 2843433, 9298646, 2167239; Product type f : factor; periplasmic chaperone 199889..200374 Escherichia coli IAI1 7126517 YP_002385673.1 CDS lpxD NC_011741.1 200378 201403 D adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 200378..201403 Escherichia coli IAI1 7125282 YP_002385674.1 CDS fabZ NC_011741.1 201508 201963 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 201508..201963 Escherichia coli IAI1 7127625 YP_002385675.1 CDS lpxA NC_011741.1 201967 202755 D catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 201967..202755 Escherichia coli IAI1 7127060 YP_002385676.1 CDS lpxB NC_011741.1 202755 203903 D catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 202755..203903 Escherichia coli IAI1 7127622 YP_002385677.1 CDS rnhB NC_011741.1 203900 204496 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 203900..204496 Escherichia coli IAI1 7127623 YP_002385678.1 CDS dnaE NC_011741.1 204533 208015 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 204533..208015 Escherichia coli IAI1 7125023 YP_002385679.1 CDS accA NC_011741.1 208028 208987 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 208028..208987 Escherichia coli IAI1 7124607 YP_002385680.1 CDS ldcC NC_011741.1 209086 211227 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97480927, 98195734, 98357244, 9226257, 9723924; Product type e : enzyme; lysine decarboxylase 2 209086..211227 Escherichia coli IAI1 7125690 YP_002385681.1 CDS yaeR NC_011741.1 211284 211673 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 211284..211673 Escherichia coli IAI1 7126398 YP_002385682.1 CDS tilS NC_011741.1 211738 213036 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 211738..213036 Escherichia coli IAI1 7126516 YP_002385683.1 CDS rof NC_011741.1 213085 213339 R Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator complement(213085..213339) Escherichia coli IAI1 7126849 YP_002385684.1 CDS yaeP NC_011741.1 213332 213532 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(213332..213532) Escherichia coli IAI1 7128614 YP_002385685.1 CDS yaeQ NC_011741.1 213698 214243 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 213698..214243 Escherichia coli IAI1 7126514 YP_002385686.1 CDS yaeJ NC_011741.1 214240 214662 D Evidence 4 : Homologs of previously reported genes of unknown function; peptidyl-tRNA hydrolase domain-containing protein 214240..214662 Escherichia coli IAI1 7126515 YP_002385687.1 CDS nlpE NC_011741.1 214676 215386 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11830644, 95362641, 95362642; Product type lp : lipoprotein; lipoprotein involved with copper homeostasis and adhesion 214676..215386 Escherichia coli IAI1 7126512 YP_002385688.1 CDS proS NC_011741.1 216418 218136 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(216418..218136) Escherichia coli IAI1 7126510 YP_002385689.1 CDS yaeB NC_011741.1 218248 218955 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(218248..218955) Escherichia coli IAI1 7126161 YP_002385690.1 CDS rcsF NC_011741.1 218952 219356 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 93094132; Product type pr : putative regulator; outer membrane lipoprotein complement(218952..219356) Escherichia coli IAI1 7126508 YP_002385691.1 CDS metQ NC_011741.1 219474 220289 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12169620, 12218041, 12819857, 1459951; Product type t : transporter; DL-methionine transporter substrate-binding subunit complement(219474..220289) Escherichia coli IAI1 7126602 YP_002385692.1 CDS metI NC_011741.1 220329 220982 R part of the MetNIQ methionine uptake system; DL-methionine transporter permease subunit complement(220329..220982) Escherichia coli IAI1 7124254 YP_002385693.1 CDS metN NC_011741.1 220975 222006 R part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit complement(220975..222006) Escherichia coli IAI1 7124249 YP_002385694.1 CDS gmhB NC_011741.1 222194 222766 D Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 222194..222766 Escherichia coli IAI1 7124253 YP_002385695.1 CDS dkgB NC_011741.1 228526 229329 D catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 228526..229329 Escherichia coli IAI1 7128005 YP_002385696.1 CDS yafC NC_011741.1 229326 230240 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(229326..230240) Escherichia coli IAI1 7124597 YP_002385697.1 CDS yafD NC_011741.1 230481 231281 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1663890; hypothetical protein 230481..231281 Escherichia coli IAI1 7126518 YP_002385698.1 CDS yafE NC_011741.1 231359 232129 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase 231359..232129 Escherichia coli IAI1 7126519 YP_002385699.1 CDS mltD NC_011741.1 232177 233535 R catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D complement(232177..233535) Escherichia coli IAI1 7126520 YP_002385700.1 CDS gloB NC_011741.1 233607 234362 R catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase complement(233607..234362) Escherichia coli IAI1 7124284 YP_002385701.1 CDS yafS NC_011741.1 234396 235118 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase 234396..235118 Escherichia coli IAI1 7128333 YP_002385702.1 CDS rnhA NC_011741.1 235115 235582 R An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H complement(235115..235582) Escherichia coli IAI1 7126526 YP_002385703.1 CDS dnaQ NC_011741.1 235647 236378 D 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 235647..236378 Escherichia coli IAI1 7125022 YP_002385704.1 CDS yafT NC_011741.1 236914 237699 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aminopeptidase 236914..237699 Escherichia coli IAI1 7128016 YP_002385705.1 CDS yafU NC_011741.1 238325 239254 R Evidence 2b : Function of strongly homologous gene; PubMedId : 15919996; Product type m : membrane component; Inner membrane protein yafU complement(238325..239254) Escherichia coli IAI1 7124431 YP_002385706.1 CDS ECIAI1_0227 NC_011741.1 239283 239765 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(239283..239765) Escherichia coli IAI1 7126689 YP_002385707.1 CDS ECIAI1_0228 NC_011741.1 239789 241231 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(239789..241231) Escherichia coli IAI1 7126980 YP_002385708.1 CDS ECIAI1_0229 NC_011741.1 241152 244676 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; IcmF-like protein complement(241152..244676) Escherichia coli IAI1 7126981 YP_002385709.1 CDS ECIAI1_0230 NC_011741.1 244695 246173 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(244695..246173) Escherichia coli IAI1 7126982 YP_002385710.1 CDS ECIAI1_0231 NC_011741.1 246112 246855 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(246112..246855) Escherichia coli IAI1 7126983 YP_002385711.1 CDS ECIAI1_0232 NC_011741.1 246852 249791 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative ATP-dependent Clp proteinase Aec27 ATP-binding chain, with chaperone activity complement(246852..249791) Escherichia coli IAI1 7126984 YP_002385712.1 CDS ECIAI1_0233 NC_011741.1 249686 250447 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein complement(249686..250447) Escherichia coli IAI1 7126985 YP_002385713.1 CDS ECIAI1_0234 NC_011741.1 250452 251783 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(250452..251783) Escherichia coli IAI1 7126986 YP_002385714.1 CDS ECIAI1_0235 NC_011741.1 251786 252310 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(251786..252310) Escherichia coli IAI1 7126987 YP_002385715.1 CDS ECIAI1_0236 NC_011741.1 252307 253608 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(252307..253608) Escherichia coli IAI1 7126988 YP_002385716.1 CDS ECIAI1_0237 NC_011741.1 253612 254700 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(253612..254700) Escherichia coli IAI1 7126989 YP_002385717.1 CDS ECIAI1_0238 NC_011741.1 254658 256508 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(254658..256508) Escherichia coli IAI1 7126990 YP_002385718.1 CDS ECIAI1_0239 NC_011741.1 256512 256925 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(256512..256925) Escherichia coli IAI1 7126991 YP_002385719.1 CDS ECIAI1_0240 NC_011741.1 256932 258407 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(256932..258407) Escherichia coli IAI1 7126992 YP_002385720.1 CDS ECIAI1_0241 NC_011741.1 258458 258682 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(258458..258682) Escherichia coli IAI1 7126993 YP_002385721.1 CDS ECIAI1_0242 NC_011741.1 258717 259217 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(258717..259217) Escherichia coli IAI1 7126994 YP_002385722.1 CDS ECIAI1_0243 NC_011741.1 259643 259786 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 259643..259786 Escherichia coli IAI1 7126995 YP_002385723.1 CDS ECIAI1_0244 NC_011741.1 259913 260431 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 259913..260431 Escherichia coli IAI1 7126996 YP_002385724.1 CDS ECIAI1_0245 NC_011741.1 260641 262782 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 260641..262782 Escherichia coli IAI1 7126997 YP_002385725.1 CDS ECIAI1_0246 NC_011741.1 262858 267084 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; RhsG core protein with extension 262858..267084 Escherichia coli IAI1 7126998 YP_002385726.1 CDS ECIAI1_0247 NC_011741.1 267087 267557 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 267087..267557 Escherichia coli IAI1 7126999 YP_002385727.1 CDS ECIAI1_0248 NC_011741.1 267665 267811 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(267665..267811) Escherichia coli IAI1 7127000 YP_002385728.1 CDS yhhI NC_011741.1 268579 269544 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype; putative transposase 268579..269544 Escherichia coli IAI1 7127140 YP_002385729.1 CDS ECIAI1_0251 NC_011741.1 269547 270026 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9696756; hypothetical protein 269547..270026 Escherichia coli IAI1 7127141 YP_002385730.1 CDS ECIAI1_0252 NC_011741.1 270292 270486 D Evidence 6 : Doubtful CDS; hypothetical protein 270292..270486 Escherichia coli IAI1 7127002 YP_002385731.1 CDS ECIAI1_0253 NC_011741.1 270561 274814 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9696756; Product type h : extrachromosomal origin; putative Rhs Core protein 270561..274814 Escherichia coli IAI1 7127003 YP_002385732.1 CDS ydcD NC_011741.1 274798 275280 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 274798..275280 Escherichia coli IAI1 7127004 YP_002385733.1 CDS ECIAI1_0255 NC_011741.1 275246 275413 D hypothetical protein 275246..275413 Escherichia coli IAI1 7127373 YP_002385734.1 CDS yncI NC_011741.1 275462 276208 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7868617, 8387990; hypothetical protein 275462..276208 Escherichia coli IAI1 7127005 YP_002385735.1 CDS yncM NC_011741.1 276252 276452 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7868617, 8387990; hypothetical protein 276252..276452 Escherichia coli IAI1 7127548 YP_002385736.1 CDS yhhI NC_011741.1 276766 277827 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype; putative transposase 276766..277827 Escherichia coli IAI1 7127551 YP_002385737.1 CDS yafV NC_011741.1 277869 278639 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8526497; Product type pe : putative enzyme; hypothetical protein complement(277869..278639) Escherichia coli IAI1 7127142 YP_002385738.1 CDS ivy NC_011741.1 278793 279266 D inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 278793..279266 Escherichia coli IAI1 7126690 YP_002385739.1 CDS fadE NC_011741.1 279309 281753 R functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase complement(279309..281753) Escherichia coli IAI1 7126091 YP_002385740.1 CDS gmhA NC_011741.1 281993 282571 D catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 281993..282571 Escherichia coli IAI1 7127064 YP_002385741.1 CDS yafJ NC_011741.1 282777 283544 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutamine amidotransferases class-II 282777..283544 Escherichia coli IAI1 7126439 YP_002385742.1 CDS yafK NC_011741.1 283515 284255 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(283515..284255) Escherichia coli IAI1 7126521 YP_002385743.1 CDS yafQ NC_011741.1 284411 284689 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15009896; Product type f : factor; toxin of the YafQ-DinJ toxin-antitoxin system complement(284411..284689) Escherichia coli IAI1 7126522 YP_002385744.1 CDS dinJ NC_011741.1 284692 284952 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99451883; Product type pf : putative factor; antitoxin of YafQ-DinJ toxin-antitoxin system complement(284692..284952) Escherichia coli IAI1 7126525 YP_002385745.1 CDS yafL NC_011741.1 285162 285911 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported hydrolase 285162..285911 Escherichia coli IAI1 7124591 YP_002385746.1 CDS ECIAI1_0268 NC_011741.1 285968 286324 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(285968..286324) Escherichia coli IAI1 7126523 YP_002385747.1 CDS ECIAI1_0269 NC_011741.1 286317 286616 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(286317..286616) Escherichia coli IAI1 7127006 YP_002385748.1 CDS fhiA NC_011741.1 286700 288439 R Evidence 7 : Gene remnant; Product type s : structure; flagellar system protein complement(286700..288439) Escherichia coli IAI1 7127007 YP_002385749.1 CDS mbhA NC_011741.1 288279 289169 D Evidence 2b : Function of strongly homologous gene; PubMedId : 15687208; Product type s : structure; hypothetical protein 288279..289169 Escherichia coli IAI1 7127096 YP_002385750.1 CDS dinB NC_011741.1 289240 290295 D involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 289240..290295 Escherichia coli IAI1 7127678 YP_002385751.1 CDS yafP NC_011741.1 290292 290744 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12813093; Product type pe : putative enzyme; hypothetical protein 290292..290744 Escherichia coli IAI1 7124586 YP_002385752.1 CDS ECIAI1_0274 NC_011741.1 290963 292129 D mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY; hypothetical protein 290963..292129 Escherichia coli IAI1 7126524 YP_002385753.1 CDS prfH NC_011741.1 292240 292740 D similar to release factor 1 and 2; peptide chain release factor-like protein 292240..292740 Escherichia coli IAI1 7127008 YP_002385754.1 CDS pepD NC_011741.1 292797 294254 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1695895, 21101837, 88121730, 92204123, 2651887; Product type e : enzyme; aminoacyl-histidine dipeptidase ABC transporter periplasmic-binding protein complement(292797..294254) Escherichia coli IAI1 7126147 YP_002385755.1 CDS gpt NC_011741.1 294515 294973 D catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 294515..294973 Escherichia coli IAI1 7124171 YP_002385756.1 CDS frsA NC_011741.1 295065 296309 D forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 295065..296309 Escherichia coli IAI1 7128462 YP_002385757.1 CDS crl NC_011741.1 296367 296768 D involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 296367..296768 Escherichia coli IAI1 7127285 YP_002385758.1 CDS phoE NC_011741.1 296807 297862 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89178658, 89380253, 92219258, 98090453, 1380671, 1848301, 1848682, 6089111, 6341601, 7679770; Product type t : transporter; outer membrane phosphoporin protein E complement(296807..297862) Escherichia coli IAI1 7126369 YP_002385759.1 CDS proB NC_011741.1 298150 299253 D catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 298150..299253 Escherichia coli IAI1 7124216 YP_002385760.1 CDS proA NC_011741.1 299265 300518 D Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 299265..300518 Escherichia coli IAI1 7126157 YP_002385761.1 CDS yagP NC_011741.1 300835 301245 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator complement(300835..301245) Escherichia coli IAI1 7128027 YP_002385762.1 CDS yagQ NC_011741.1 301224 302180 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(301224..302180) Escherichia coli IAI1 7126691 YP_002385763.1 CDS yagR NC_011741.1 302190 304388 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(302190..304388) Escherichia coli IAI1 7126692 YP_002385764.1 CDS yagS NC_011741.1 304385 305341 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(304385..305341) Escherichia coli IAI1 7126693 YP_002385765.1 CDS yagT NC_011741.1 305338 306027 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative xanthine dehydrogenase iron-sulfur-binding subunit complement(305338..306027) Escherichia coli IAI1 7126694 YP_002385766.1 CDS yagU NC_011741.1 306445 307059 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 306445..307059 Escherichia coli IAI1 7126695 YP_002385767.1 CDS ECIAI1_0289 NC_011741.1 307133 307312 D Evidence 6 : Doubtful CDS; hypothetical protein 307133..307312 Escherichia coli IAI1 7126696 YP_002385768.1 CDS yagV NC_011741.1 307949 308659 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(307949..308659) Escherichia coli IAI1 7127009 YP_002385769.1 CDS yagW NC_011741.1 308628 310271 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative surface or exported protein complement(308628..310271) Escherichia coli IAI1 7126697 YP_002385770.1 CDS yagX NC_011741.1 310261 312786 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(310261..312786) Escherichia coli IAI1 7126698 YP_002385771.1 CDS yagY NC_011741.1 312812 313480 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(312812..313480) Escherichia coli IAI1 7126699 YP_002385772.1 CDS ecpA NC_011741.1 313538 314125 R Evidence 2b : Function of strongly homologous gene; PubMedId : 17563352, 11466275; Product type s : structure; common pilus ECP complement(313538..314125) Escherichia coli IAI1 7126700 YP_002385773.1 CDS ykgK NC_011741.1 314200 314790 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator complement(314200..314790) Escherichia coli IAI1 7125046 YP_002385774.1 CDS rpmE2 NC_011741.1 315967 316230 R RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B complement(315967..316230) Escherichia coli IAI1 7126652 YP_002385775.1 CDS ECIAI1_0297 NC_011741.1 317810 322063 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative adhesin 317810..322063 Escherichia coli IAI1 7126653 YP_002385776.1 CDS ykgA NC_011741.1 322185 323042 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator ykgA complement(322185..323042) Escherichia coli IAI1 7127010 YP_002385777.1 CDS ykgB NC_011741.1 323638 324237 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(323638..324237) Escherichia coli IAI1 7126643 YP_002385778.1 CDS ykgI NC_011741.1 324240 324476 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(324240..324476) Escherichia coli IAI1 7126644 YP_002385779.1 CDS ykgC NC_011741.1 324585 325910 R Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase complement(324585..325910) Escherichia coli IAI1 7126651 YP_002385780.1 CDS ykgD NC_011741.1 326136 326990 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative AraC-type DNA-binding transcriptional regulator 326136..326990 Escherichia coli IAI1 7126645 YP_002385781.1 CDS ykgE NC_011741.1 327517 328236 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydroxyacid oxidoreductase 327517..328236 Escherichia coli IAI1 7126646 YP_002385782.1 CDS ykgF NC_011741.1 328247 329674 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase subunit 328247..329674 Escherichia coli IAI1 7126647 YP_002385783.1 CDS ykgG NC_011741.1 329667 330362 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 329667..330362 Escherichia coli IAI1 7126648 YP_002385784.1 CDS ECIAI1_0306 NC_011741.1 330436 330633 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(330436..330633) Escherichia coli IAI1 7126649 YP_002385785.1 CDS ykgH NC_011741.1 330608 331273 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(330608..331273) Escherichia coli IAI1 7127011 YP_002385786.1 CDS betA NC_011741.1 331485 333155 R catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase complement(331485..333155) Escherichia coli IAI1 7126650 YP_002385787.1 CDS betB NC_011741.1 333169 334641 R catalyzes the formation of betaine from betaine aldehyde; betaine aldehyde dehydrogenase complement(333169..334641) Escherichia coli IAI1 7124394 YP_002385788.1 CDS betI NC_011741.1 334655 335242 R HTH-type; bet1; Repressor involved in choline regulation of the bet genes; transcriptional regulator BetI complement(334655..335242) Escherichia coli IAI1 7124395 YP_002385789.1 CDS betT NC_011741.1 335371 337404 D proton-motive-force-driven choline transporter; choline transport protein BetT 335371..337404 Escherichia coli IAI1 7124396 YP_002385790.1 CDS ECIAI1_0312 NC_011741.1 337911 341960 D Evidence 2b : Function of strongly homologous gene; Product type pm : putative membrane component; AidA-I adhesin-like protein 337911..341960 Escherichia coli IAI1 7124397 YP_002385791.1 CDS yahA NC_011741.1 342102 343190 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15995192; Product type e : enzyme; cyclic di-GMP phosphodiesterase 342102..343190 Escherichia coli IAI1 7127012 YP_002385792.1 CDS yahB NC_011741.1 343232 344164 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(343232..344164) Escherichia coli IAI1 7126701 YP_002385793.1 CDS yahC NC_011741.1 344256 344753 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(344256..344753) Escherichia coli IAI1 7126702 YP_002385794.1 CDS yahD NC_011741.1 345011 345616 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 345011..345616 Escherichia coli IAI1 7126703 YP_002385795.1 CDS yahE NC_011741.1 345656 346519 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 345656..346519 Escherichia coli IAI1 7126704 YP_002385796.1 CDS yahF NC_011741.1 346509 348056 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 346509..348056 Escherichia coli IAI1 7126705 YP_002385797.1 CDS yahG NC_011741.1 348056 349474 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 348056..349474 Escherichia coli IAI1 7126706 YP_002385798.1 CDS yahI NC_011741.1 349617 350567 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7711027, 11523892; Product type pe : putative enzyme; putative carbamate kinase 349617..350567 Escherichia coli IAI1 7126707 YP_002385799.1 CDS yahJ NC_011741.1 350577 351959 D metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain; putative deaminase 350577..351959 Escherichia coli IAI1 7126708 YP_002385800.1 CDS ECIAI1_0322 NC_011741.1 352228 352668 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 352228..352668 Escherichia coli IAI1 7126709 YP_002385801.1 CDS ECIAI1_0323 NC_011741.1 352920 353906 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ribose ABC transporter substrate-binding protein 352920..353906 Escherichia coli IAI1 7127013 YP_002385802.1 CDS ECIAI1_0324 NC_011741.1 353940 355439 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar ABC transporter ATP-binding protein 353940..355439 Escherichia coli IAI1 7127014 YP_002385803.1 CDS ECIAI1_0325 NC_011741.1 355432 356403 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative sugar ABC transporter permease 355432..356403 Escherichia coli IAI1 7127015 YP_002385804.1 CDS ECIAI1_0326 NC_011741.1 356370 357356 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative sugar ABC transporter permease 356370..357356 Escherichia coli IAI1 7127016 YP_002385805.1 CDS yahK NC_011741.1 357443 358492 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 357443..358492 Escherichia coli IAI1 7127017 YP_002385806.1 CDS yahL NC_011741.1 358735 359550 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 358735..359550 Escherichia coli IAI1 7126710 YP_002385807.1 CDS yahM NC_011741.1 359963 360208 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 359963..360208 Escherichia coli IAI1 7128038 YP_002385808.1 CDS yahN NC_011741.1 360225 360896 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12879215; Product type t : transporter; neutral amino-acid efflux system complement(360225..360896) Escherichia coli IAI1 7126712 YP_002385809.1 CDS yahO NC_011741.1 361043 361318 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 361043..361318 Escherichia coli IAI1 7126713 YP_002385810.1 CDS prpR NC_011741.1 361419 363005 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9325432, 15805526; Product type r : regulator; DNA-binding transcriptional activator complement(361419..363005) Escherichia coli IAI1 7126714 YP_002385811.1 CDS prpB NC_011741.1 363244 364134 D catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase 363244..364134 Escherichia coli IAI1 7126170 YP_002385812.1 CDS prpC NC_011741.1 364179 365348 D catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase 364179..365348 Escherichia coli IAI1 7126166 YP_002385813.1 CDS prpD NC_011741.1 365382 366833 D functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C; 2-methylcitrate dehydratase 365382..366833 Escherichia coli IAI1 7126167 YP_002385814.1 CDS prpE NC_011741.1 366873 368759 D catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; propionyl-CoA synthetase 366873..368759 Escherichia coli IAI1 7126168 YP_002385815.1 CDS ECIAI1_0337 NC_011741.1 369127 370107 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 369127..370107 Escherichia coli IAI1 7126169 YP_002385816.1 CDS codB NC_011741.1 370376 371635 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92349961; Product type t : transporter; cytosine permease 370376..371635 Escherichia coli IAI1 7127018 YP_002385817.1 CDS codA NC_011741.1 371625 372908 D Catalyzes the deamination of cytosine to uracil and ammonia; cytosine deaminase 371625..372908 Escherichia coli IAI1 7126350 YP_002385818.1 CDS cynR NC_011741.1 372948 373847 R controls the expression of the cynTSX operon involved in degrading and using cyanate as a sole nitrogen source; DNA-binding transcriptional regulator CynR complement(372948..373847) Escherichia coli IAI1 7126349 YP_002385819.1 CDS cynT NC_011741.1 373957 374616 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91242169, 92156106, 94075239, 3049588; Product type e : enzyme; carbonic anhydrase 373957..374616 Escherichia coli IAI1 7126878 YP_002385820.1 CDS cynS NC_011741.1 374647 375117 D catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide; cyanate hydratase 374647..375117 Escherichia coli IAI1 7126880 YP_002385821.1 CDS cynX NC_011741.1 375150 376304 D MFS transporter family member induced in the presence of cyanate as part of a 3 gene operon; not essential; putative cyanate transporter 375150..376304 Escherichia coli IAI1 7126879 YP_002385822.1 CDS lacY NC_011741.1 376383 377636 R lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease complement(376383..377636) Escherichia coli IAI1 7126881 YP_002385823.1 CDS lacZ NC_011741.1 377688 380762 R forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon; beta-D-galactosidase complement(377688..380762) Escherichia coli IAI1 7126394 YP_002385824.1 CDS lacI NC_011741.1 380885 381967 R transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor complement(380885..381967) Escherichia coli IAI1 7126395 YP_002385825.1 CDS mhpR NC_011741.1 382044 382991 R activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional activator MhpR complement(382044..382991) Escherichia coli IAI1 7126393 YP_002385826.1 CDS mhpA NC_011741.1 383068 384732 D catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 383068..384732 Escherichia coli IAI1 7124268 YP_002385827.1 CDS mhpB NC_011741.1 384734 385678 D catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family; 3-(2,3-dihydroxyphenyl)propionate dioxygenase 384734..385678 Escherichia coli IAI1 7124262 YP_002385828.1 CDS mhpC NC_011741.1 385681 386562 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87008429, 94002258, 15663942; Product type e : enzyme; 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase 385681..386562 Escherichia coli IAI1 7124263 YP_002385829.1 CDS mhpD NC_011741.1 386572 387381 D catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid; 2-keto-4-pentenoate hydratase 386572..387381 Escherichia coli IAI1 7124264 YP_002385830.1 CDS mhpF NC_011741.1 387378 388328 D catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 387378..388328 Escherichia coli IAI1 7124265 YP_002385831.1 CDS mhpE NC_011741.1 388325 389338 D catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 388325..389338 Escherichia coli IAI1 7124267 YP_002385832.1 CDS mhpT NC_011741.1 389514 390725 D Evidence 2b : Function of strongly homologous gene; PubMedId : 7961399; Product type t : transporter; putative 3-hydroxyphenylpropionic transporter MhpT 389514..390725 Escherichia coli IAI1 7124266 YP_002385833.1 CDS yaiL NC_011741.1 390827 391366 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15115803, 12878731, 13129938; Product type e : enzyme; nucleoprotein/polynucleotide-associated enzyme 390827..391366 Escherichia coli IAI1 7124269 YP_002385834.1 CDS frmB NC_011741.1 391491 392324 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16567800, 15466022; Product type e : enzyme; S-formylglutathione hydrolase complement(391491..392324) Escherichia coli IAI1 7126720 YP_002385835.1 CDS frmA NC_011741.1 392417 393526 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15466022, 87172301, 1731906; Product type e : enzyme; alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase complement(392417..393526) Escherichia coli IAI1 7127281 YP_002385836.1 CDS frmR NC_011741.1 393561 393836 R formaldehyde-induced negative regulator of the frmRAB operon; regulator protein FrmR complement(393561..393836) Escherichia coli IAI1 7127280 YP_002385837.1 CDS yaiO NC_011741.1 394021 394794 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(394021..394794) Escherichia coli IAI1 7127283 YP_002385838.1 CDS yaiX NC_011741.1 394796 395506 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transferase complement(394796..395506) Escherichia coli IAI1 7126721 YP_002385839.1 CDS yaiP NC_011741.1 395355 396551 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated glycosyltransferase complement(395355..396551) Escherichia coli IAI1 7126726 YP_002385840.1 CDS yaiS NC_011741.1 396561 397232 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(396561..397232) Escherichia coli IAI1 7126722 YP_002385841.1 CDS tauA NC_011741.1 397848 398810 D with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit 397848..398810 Escherichia coli IAI1 7126723 YP_002385842.1 CDS tauB NC_011741.1 398823 399590 D Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding subunit 398823..399590 Escherichia coli IAI1 7126219 YP_002385843.1 CDS tauC NC_011741.1 399587 400414 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9401024, 96404792; Product type t : transporter; taurine transporter subunit 399587..400414 Escherichia coli IAI1 7126220 YP_002385844.1 CDS tauD NC_011741.1 400411 401262 D catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase 400411..401262 Escherichia coli IAI1 7126221 YP_002385845.1 CDS hemB NC_011741.1 401368 402342 R catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase complement(401368..402342) Escherichia coli IAI1 7126222 YP_002385846.1 CDS ECIAI1_0369 NC_011741.1 402865 405843 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative flagellin structural protein 402865..405843 Escherichia coli IAI1 7128506 YP_002385847.1 CDS yaiV NC_011741.1 405886 406554 D Evidence 4 : Homologs of previously reported genes of unknown function; putative DNA-binding transcriptional regulator 405886..406554 Escherichia coli IAI1 7127019 YP_002385848.1 CDS ampH NC_011741.1 406555 407712 R this protein has no known enzymatic function; beta-lactam binding protein AmpH complement(406555..407712) Escherichia coli IAI1 7126724 YP_002385849.1 CDS ECIAI1_0372 NC_011741.1 407850 408044 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 407850..408044 Escherichia coli IAI1 7125760 YP_002385850.1 CDS sbmA NC_011741.1 408064 409284 D in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transport protein 408064..409284 Escherichia coli IAI1 7127020 YP_002385851.1 CDS yaiW NC_011741.1 409297 410391 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 409297..410391 Escherichia coli IAI1 7124678 YP_002385852.1 CDS yaiY NC_011741.1 410450 410758 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(410450..410758) Escherichia coli IAI1 7126725 YP_002385853.1 CDS yaiZ NC_011741.1 410886 411230 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 410886..411230 Escherichia coli IAI1 7126727 YP_002385854.1 CDS ddl NC_011741.1 411254 412348 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(411254..412348) Escherichia coli IAI1 7126728 YP_002385855.1 CDS ECIAI1_0378 NC_011741.1 412426 412629 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 412426..412629 Escherichia coli IAI1 7124548 YP_002385856.1 CDS ECIAI1_0379 NC_011741.1 412862 413695 R Evidence 2b : Function of strongly homologous gene; PubMedId : 1718819, 7737514; Product type pe : putative enzyme; transposase, ORF B, IS3 family, IS407 group complement(412862..413695) Escherichia coli IAI1 7127021 YP_002385857.1 CDS ECIAI1_0380 NC_011741.1 413719 413982 R Evidence 2b : Function of strongly homologous gene; PubMedId : 15126494, 7737514; Product type pe : putative enzyme; transposase, ORF A, IS3 family, IS407 group complement(413719..413982) Escherichia coli IAI1 7127022 YP_002385858.1 CDS yaiB NC_011741.1 414057 414296 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 414057..414296 Escherichia coli IAI1 7127023 YP_002385859.1 CDS phoA NC_011741.1 414397 415812 D Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme; alkaline phosphatase 414397..415812 Escherichia coli IAI1 7126716 YP_002385860.1 CDS psiF NC_011741.1 415931 416251 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3533724, 2160940; Product type f : factor; hypothetical protein 415931..416251 Escherichia coli IAI1 7124214 YP_002385861.1 CDS adrA NC_011741.1 416353 417468 D catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA 416353..417468 Escherichia coli IAI1 7126173 YP_002385862.1 CDS proC NC_011741.1 417485 418294 R catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase complement(417485..418294) Escherichia coli IAI1 7126717 YP_002385863.1 CDS yaiI NC_011741.1 418414 418872 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 418414..418872 Escherichia coli IAI1 7126158 YP_002385864.1 CDS aroL NC_011741.1 419055 419579 D type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase II 419055..419579 Escherichia coli IAI1 7126719 YP_002385865.1 CDS yaiA NC_011741.1 419629 419820 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 419629..419820 Escherichia coli IAI1 7125811 YP_002385866.1 CDS aroM NC_011741.1 420078 420755 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 86085675, 3001025; hypothetical protein 420078..420755 Escherichia coli IAI1 7126715 YP_002385867.1 CDS yaiE NC_011741.1 420827 421111 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 420827..421111 Escherichia coli IAI1 7125812 YP_002385868.1 CDS ECIAI1_0392 NC_011741.1 421372 421734 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 421372..421734 Escherichia coli IAI1 7126718 YP_002385869.1 CDS rdgC NC_011741.1 421812 422723 R Required for efficient pilin antigenic variation; recombination associated protein complement(421812..422723) Escherichia coli IAI1 7127024 YP_002385870.1 CDS mak NC_011741.1 422848 423756 D catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 422848..423756 Escherichia coli IAI1 7126603 YP_002385871.1 CDS araJ NC_011741.1 423899 425083 R member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ complement(423899..425083) Escherichia coli IAI1 7127653 YP_002385872.1 CDS sbcC NC_011741.1 425209 428352 R with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease subunit SbcC complement(425209..428352) Escherichia coli IAI1 7125783 YP_002385873.1 CDS sbcD NC_011741.1 428349 429551 R with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease subunit SbcD complement(428349..429551) Escherichia coli IAI1 7124676 YP_002385874.1 CDS phoB NC_011741.1 429741 430430 D two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 429741..430430 Escherichia coli IAI1 7124677 YP_002385875.1 CDS phoR NC_011741.1 430488 431783 D membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 430488..431783 Escherichia coli IAI1 7124215 YP_002385876.1 CDS ECIAI1_0400 NC_011741.1 431794 431904 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(431794..431904) Escherichia coli IAI1 7124220 YP_002385877.1 CDS brnQ NC_011741.1 432190 433509 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3078876, 6998958, 3550103, 7984428; Product type t : transporter; branched chain amino acid transporter 432190..433509 Escherichia coli IAI1 7127025 YP_002385878.1 CDS proY NC_011741.1 433585 434958 D cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; putative proline-specific permease 433585..434958 Escherichia coli IAI1 7124420 YP_002385879.1 CDS malZ NC_011741.1 435114 436931 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92184757, 1706703, 1918057; Product type e : enzyme; maltodextrin glucosidase 435114..436931 Escherichia coli IAI1 7126165 YP_002385880.1 CDS acpH NC_011741.1 436936 437517 R Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; acyl carrier protein phosphodiesterase complement(436936..437517) Escherichia coli IAI1 7127666 YP_002385881.1 CDS queA NC_011741.1 437610 438680 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 437610..438680 Escherichia coli IAI1 7125702 YP_002385882.1 CDS tgt NC_011741.1 438736 439863 D Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 438736..439863 Escherichia coli IAI1 7126582 YP_002385883.1 CDS yajC NC_011741.1 439886 440218 D member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 439886..440218 Escherichia coli IAI1 7126239 YP_002385884.1 CDS secD NC_011741.1 440246 442093 D part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 440246..442093 Escherichia coli IAI1 7126729 YP_002385885.1 CDS secF NC_011741.1 442104 443075 D forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 442104..443075 Escherichia coli IAI1 7124693 YP_002385886.1 CDS yajD NC_011741.1 443204 443551 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 443204..443551 Escherichia coli IAI1 7124695 YP_002385887.1 CDS tsx NC_011741.1 443728 444612 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91092502, 91358319, 93352541; Product type m : membrane component; nucleoside channel phage T6/colicin K receptor complement(443728..444612) Escherichia coli IAI1 7126730 YP_002385888.1 CDS yajI NC_011741.1 444911 445450 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein complement(444911..445450) Escherichia coli IAI1 7127512 YP_002385889.1 CDS nrdR NC_011741.1 445601 446050 D Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator NrdR 445601..446050 Escherichia coli IAI1 7126732 YP_002385890.1 CDS ribD NC_011741.1 446054 447157 D riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 446054..447157 Escherichia coli IAI1 7125941 YP_002385891.1 CDS ribH NC_011741.1 447246 447716 D RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 447246..447716 Escherichia coli IAI1 7124995 YP_002385892.1 CDS nusB NC_011741.1 447736 448155 D Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 447736..448155 Escherichia coli IAI1 7124996 YP_002385893.1 CDS thiL NC_011741.1 448233 449210 D catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 448233..449210 Escherichia coli IAI1 7125974 YP_002385894.1 CDS pgpA NC_011741.1 449188 449706 D hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 449188..449706 Escherichia coli IAI1 7126247 YP_002385895.1 CDS yajO NC_011741.1 449760 450734 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217, 16077126; Product type e : enzyme; aldoketo-oxidoreductase complement(449760..450734) Escherichia coli IAI1 7124189 YP_002385896.1 CDS dxs NC_011741.1 450789 452651 R catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase complement(450789..452651) Escherichia coli IAI1 7126734 YP_002385897.1 CDS ispA NC_011741.1 452676 453575 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89291702, 91210228; Product type e : enzyme; geranyltranstransferase complement(452676..453575) Escherichia coli IAI1 7125036 YP_002385898.1 CDS xseB NC_011741.1 453575 453817 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(453575..453817) Escherichia coli IAI1 7126079 YP_002385899.1 CDS thiI NC_011741.1 454023 455471 D Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 454023..455471 Escherichia coli IAI1 7126475 YP_002385900.1 CDS yajL NC_011741.1 455525 456115 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 97039868, 99173753, 99311269; DJ-1 family protein complement(455525..456115) Escherichia coli IAI1 7126246 YP_002385901.1 CDS panE NC_011741.1 456078 456989 R ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase complement(456078..456989) Escherichia coli IAI1 7126733 YP_002385902.1 CDS yajQ NC_011741.1 457157 457648 D putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; putative nucleotide-binding protein 457157..457648 Escherichia coli IAI1 7124153 YP_002385903.1 CDS yajR NC_011741.1 457776 459140 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter complement(457776..459140) Escherichia coli IAI1 7126735 YP_002385904.1 CDS ECIAI1_0428 NC_011741.1 459488 460483 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative zinc-dependent hydrolase 459488..460483 Escherichia coli IAI1 7126736 YP_002385905.1 CDS ECIAI1_0429 NC_011741.1 460539 461081 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase complement(460539..461081) Escherichia coli IAI1 7127026 YP_002385906.1 CDS ECIAI1_0430 NC_011741.1 461065 461442 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(461065..461442) Escherichia coli IAI1 7127027 YP_002385907.1 CDS cyoE NC_011741.1 461561 462451 R converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase complement(461561..462451) Escherichia coli IAI1 7127028 YP_002385908.1 CDS cyoD NC_011741.1 462463 462792 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 90366572, 92345252, 9378722, 98021084, 11017202, 2162835; Product type c : carrier; cytochrome o ubiquinol oxidase subunit IV complement(462463..462792) Escherichia coli IAI1 7126886 YP_002385909.1 CDS cyoC NC_011741.1 462792 463406 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 92345252, 93349845, 9378722, 98021084, 11017202, 2162835, 2168206; Product type c : carrier; cytochrome o ubiquinol oxidase subunit III complement(462792..463406) Escherichia coli IAI1 7126885 YP_002385910.1 CDS cyoB NC_011741.1 463396 465387 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 92345252, 93349845, 9378722, 98021084, 11017202, 2162835, 2168206; Product type c : carrier; cytochrome o ubiquinol oxidase subunit I complement(463396..465387) Escherichia coli IAI1 7126884 YP_002385911.1 CDS cyoA NC_011741.1 465409 466356 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92112945, 92371427, 9378722, 98021084, 11017202, 1322173, 2162835, 2162837, 2165491, 2168206, 8231804, 8618822; Product type c : carrier; cytochrome o ubiquinol oxidase subunit II complement(465409..466356) Escherichia coli IAI1 7126883 YP_002385912.1 CDS ampG NC_011741.1 466816 468291 R in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter complement(466816..468291) Escherichia coli IAI1 7126882 YP_002385913.1 CDS yajG NC_011741.1 468335 468913 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein complement(468335..468913) Escherichia coli IAI1 7125759 YP_002385914.1 CDS bolA NC_011741.1 469218 469535 D positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA 469218..469535 Escherichia coli IAI1 7126731 YP_002385915.1 CDS ECIAI1_0439 NC_011741.1 469469 469732 D Evidence 6 : Doubtful CDS; hypothetical protein 469469..469732 Escherichia coli IAI1 7124418 YP_002385916.1 CDS tig NC_011741.1 469879 471177 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 469879..471177 Escherichia coli IAI1 7127029 YP_002385917.1 CDS clpP NC_011741.1 471423 472046 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 471423..472046 Escherichia coli IAI1 7126259 YP_002385918.1 CDS clpX NC_011741.1 472172 473446 D binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 472172..473446 Escherichia coli IAI1 7126334 YP_002385919.1 CDS lon NC_011741.1 473634 475988 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10094703, 14665623, 8939438, 91072263, 97137085, 2984174, 3042779, 3289547, 7988699, 8226758, 8294008; Product type e : enzyme; DNA-binding ATP-dependent protease La 473634..475988 Escherichia coli IAI1 7127967 YP_002385920.1 CDS hupB NC_011741.1 476197 476469 D histone-like DNA-binding protein; transcriptional regulator HU subunit beta 476197..476469 Escherichia coli IAI1 7126438 YP_002385921.1 CDS ppiD NC_011741.1 476661 478532 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9670013; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase 476661..478532 Escherichia coli IAI1 7125325 YP_002385922.1 CDS ybaV NC_011741.1 478683 479054 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 478683..479054 Escherichia coli IAI1 7126135 YP_002385923.1 CDS ybaW NC_011741.1 479160 479558 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 479160..479558 Escherichia coli IAI1 7126750 YP_002385924.1 CDS queC NC_011741.1 479610 480305 R YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC complement(479610..480305) Escherichia coli IAI1 7126751 YP_002385925.1 CDS ybaE NC_011741.1 480370 482070 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(480370..482070) Escherichia coli IAI1 7126583 YP_002385926.1 CDS cof NC_011741.1 482170 482988 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217; Product type e : enzyme; thiamin pyrimidine pyrophosphate hydrolase 482170..482988 Escherichia coli IAI1 7126739 YP_002385927.1 CDS ybaO NC_011741.1 482988 483599 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator (Lrp-like) 482988..483599 Escherichia coli IAI1 7126351 YP_002385928.1 CDS mdlA NC_011741.1 483629 485401 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 94124004, 10850996; Product type pt : putative transporter; putative multidrug transporter membrane/ATP-binding protein 483629..485401 Escherichia coli IAI1 7126745 YP_002385929.1 CDS mdlB NC_011741.1 485394 487175 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 94124004; Product type pt : putative transporter; putative multidrug transporter membrane/ATP-binding protein 485394..487175 Escherichia coli IAI1 7127681 YP_002385930.1 CDS glnK NC_011741.1 487356 487694 D indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 487356..487694 Escherichia coli IAI1 7127682 YP_002385931.1 CDS amtB NC_011741.1 487724 489010 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22020597, 9618533, 10931328, 1645722, 7984428; Product type t : transporter; ammonium transporter 487724..489010 Escherichia coli IAI1 7128327 YP_002385932.1 CDS tesB NC_011741.1 489059 489919 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86139906, 91250410, 10876240; Product type e : enzyme; acyl-CoA thioesterase II complement(489059..489919) Escherichia coli IAI1 7125761 YP_002385933.1 CDS ybaY NC_011741.1 490137 490709 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 490137..490709 Escherichia coli IAI1 7126237 YP_002385934.1 CDS ybaZ NC_011741.1 490740 491129 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methylated DNA-protein cysteine alkyltransferase complement(490740..491129) Escherichia coli IAI1 7126752 YP_002385935.1 CDS ybaA NC_011741.1 491430 491783 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 491430..491783 Escherichia coli IAI1 7127095 YP_002385936.1 CDS ylaB NC_011741.1 491825 493375 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(491825..493375) Escherichia coli IAI1 7126737 YP_002385937.1 CDS ylaC NC_011741.1 493539 494009 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(493539..494009) Escherichia coli IAI1 7126655 YP_002385938.1 CDS maa NC_011741.1 494125 494676 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82180540, 91310703, 9600841; Product type e : enzyme; maltose O-acetyltransferase complement(494125..494676) Escherichia coli IAI1 7126656 YP_002385939.1 CDS hha NC_011741.1 494847 495065 R with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein complement(494847..495065) Escherichia coli IAI1 7127649 YP_002385940.1 CDS ybaJ NC_011741.1 495091 495465 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1956303, 7984428, 14645275; hypothetical protein complement(495091..495465) Escherichia coli IAI1 7128524 YP_002385941.1 CDS acrB NC_011741.1 496011 499160 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12351840, 12654283, 15111118, 15155734, 21450803, 94012493, 10920254, 7651136; Product type t : transporter; multidrug efflux system protein complement(496011..499160) Escherichia coli IAI1 7126740 YP_002385942.1 CDS acrA NC_011741.1 499183 500376 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15155734, 21450803, 383699, 390095, 94012493, 10920254, 7651136; Product type t : transporter; multidrug efflux system complement(499183..500376) Escherichia coli IAI1 7125707 YP_002385943.1 CDS acrR NC_011741.1 500518 501165 D regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR 500518..501165 Escherichia coli IAI1 7125706 YP_002385944.1 CDS kefA NC_011741.1 501293 504655 D small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 501293..504655 Escherichia coli IAI1 7125711 YP_002385945.1 CDS ybaM NC_011741.1 504867 505028 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(504867..505028) Escherichia coli IAI1 7126385 YP_002385946.1 CDS priC NC_011741.1 505042 505569 R PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' complement(505042..505569) Escherichia coli IAI1 7126743 YP_002385947.1 CDS ybaN NC_011741.1 505639 506016 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 505639..506016 Escherichia coli IAI1 7126150 YP_002385948.1 CDS apt NC_011741.1 506169 506720 D catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 506169..506720 Escherichia coli IAI1 7126744 YP_002385949.1 CDS dnaX NC_011741.1 506849 508780 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 506849..508780 Escherichia coli IAI1 7125773 YP_002385950.1 CDS ybaB NC_011741.1 508833 509162 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15322138, 1698765, 2674903; hypothetical protein 508833..509162 Escherichia coli IAI1 7124614 YP_002385951.1 CDS recR NC_011741.1 509162 509767 D involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 509162..509767 Escherichia coli IAI1 7126738 YP_002385952.1 CDS htpG NC_011741.1 509877 511751 D molecular chaperone; heat shock protein 90 509877..511751 Escherichia coli IAI1 7124955 YP_002385953.1 CDS adk NC_011741.1 511932 512576 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 511932..512576 Escherichia coli IAI1 7125318 YP_002385954.1 CDS hemH NC_011741.1 512708 513670 D protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 512708..513670 Escherichia coli IAI1 7125722 YP_002385955.1 CDS aes NC_011741.1 513667 514626 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9401025, 98244813, 2051480, 7721718; Product type e : enzyme; acetyl esterase complement(513667..514626) Escherichia coli IAI1 7128512 YP_002385956.1 CDS gsk NC_011741.1 514778 516082 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90155203, 95238302, 2051480; Product type e : enzyme; inosine/guanosine kinase 514778..516082 Escherichia coli IAI1 7125726 YP_002385957.1 CDS ybaL NC_011741.1 516215 517891 R YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; putative cation:proton antiport protein complement(516215..517891) Escherichia coli IAI1 7128473 YP_002385958.1 CDS fsr NC_011741.1 518129 519349 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 97074653, 8917080; Product type t : transporter; fosmidomycin efflux systemprotein complement(518129..519349) Escherichia coli IAI1 7126742 YP_002385959.1 CDS ushA NC_011741.1 519567 521219 D catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic 519567..521219 Escherichia coli IAI1 7128230 YP_002385960.1 CDS ybaK NC_011741.1 521256 521735 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(521256..521735) Escherichia coli IAI1 7124649 YP_002385961.1 CDS ybaP NC_011741.1 521939 522733 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(521939..522733) Escherichia coli IAI1 7127977 YP_002385962.1 CDS ybaQ NC_011741.1 522871 523212 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 522871..523212 Escherichia coli IAI1 7126746 YP_002385963.1 CDS copA NC_011741.1 523326 525830 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12351646, 20105527, 11167016, 11500054, 9868784; Product type t : transporter; copper exporting ATPase complement(523326..525830) Escherichia coli IAI1 7126747 YP_002385964.1 CDS ybaS NC_011741.1 526092 527024 D catalyzes the formation of glutamate from glutamine; glutaminase 526092..527024 Escherichia coli IAI1 7126352 YP_002385965.1 CDS ybaT NC_011741.1 527027 528319 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative nitrogen-containing metabolite transporter 527027..528319 Escherichia coli IAI1 7126748 YP_002385966.1 CDS cueR NC_011741.1 528444 528851 D activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR 528444..528851 Escherichia coli IAI1 7126749 YP_002385967.1 CDS ybbJ NC_011741.1 528852 529307 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(528852..529307) Escherichia coli IAI1 7126858 YP_002385968.1 CDS ybbK NC_011741.1 529307 530224 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative protease, membrane anchored complement(529307..530224) Escherichia coli IAI1 7126757 YP_002385969.1 CDS ybbL NC_011741.1 530370 531047 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein YbbL 530370..531047 Escherichia coli IAI1 7126758 YP_002385970.1 CDS ybbM NC_011741.1 531034 531813 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative ABC transporter permease 531034..531813 Escherichia coli IAI1 7126759 YP_002385971.1 CDS ybbN NC_011741.1 531876 532730 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative thioredoxin domain-containing protein complement(531876..532730) Escherichia coli IAI1 7126760 YP_002385972.1 CDS ybbO NC_011741.1 532791 533600 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; short chain dehydrogenase complement(532791..533600) Escherichia coli IAI1 7126761 YP_002385973.1 CDS tesA NC_011741.1 533590 534216 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91270121, 91324311, 93163029, 93252782, 94179121, 99353977, 1864840, 8432696, 8098033; Product type e : enzyme; multifunctional acyl-CoA thioesterase I and protease I and lysophospholipase L1 complement(533590..534216) Escherichia coli IAI1 7126762 YP_002385974.1 CDS ybbA NC_011741.1 534184 534870 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein YbbA 534184..534870 Escherichia coli IAI1 7126236 YP_002385975.1 CDS ybbP NC_011741.1 534867 537281 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type t : transporter; putative ABC transporter permease 534867..537281 Escherichia coli IAI1 7126754 YP_002385976.1 CDS rhsD NC_011741.1 537711 542000 D Evidence 2b : Function of strongly homologous gene; PubMedId : 98361897, 1766878, 2403547, 2644231, 7934896; Product type h : extrachromosomal origin; rhsD element protein 537711..542000 Escherichia coli IAI1 7126763 YP_002385977.1 CDS ybbC NC_011741.1 542040 542408 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 542040..542408 Escherichia coli IAI1 7124987 YP_002385978.1 CDS ylbH NC_011741.1 542408 543118 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1766878, 7934896; Product type h : extrachromosomal origin; hypothetical protein 542408..543118 Escherichia coli IAI1 7126756 YP_002385979.1 CDS ECIAI1_0504 NC_011741.1 543876 544091 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(543876..544091) Escherichia coli IAI1 7127030 YP_002385980.1 CDS ECIAI1_0505 NC_011741.1 544078 544512 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative regulator with homeodomain-like DNA binding domain complement(544078..544512) Escherichia coli IAI1 7127031 YP_002385981.1 CDS ybbB NC_011741.1 544592 545686 R catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase complement(544592..545686) Escherichia coli IAI1 7127032 YP_002385982.1 CDS ybbS NC_011741.1 545755 546681 R activator of the allDC-ylbA operon involved in allantoin utilization; DNA-binding transcriptional activator AllS complement(545755..546681) Escherichia coli IAI1 7126755 YP_002385983.1 CDS allA NC_011741.1 546911 547393 D catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 546911..547393 Escherichia coli IAI1 7126764 YP_002385984.1 CDS allR NC_011741.1 547471 548286 D regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR 547471..548286 Escherichia coli IAI1 7125745 YP_002385985.1 CDS gcl NC_011741.1 548376 550157 D catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 548376..550157 Escherichia coli IAI1 7125749 YP_002385986.1 CDS hyi NC_011741.1 550170 550946 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20029625, 8440684; Product type e : enzyme; hydroxypyruvate isomerase 550170..550946 Escherichia coli IAI1 7128292 YP_002385987.1 CDS glxR NC_011741.1 551046 551924 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20069628; Product type e : enzyme; tartronate semialdehyde reductase, NADH-dependent 551046..551924 Escherichia coli IAI1 7126028 YP_002385988.1 CDS ybbW NC_011741.1 552093 553547 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1293888; Product type t : transporter; allantoin permease 552093..553547 Escherichia coli IAI1 7128357 YP_002385989.1 CDS allB NC_011741.1 553607 554968 D Plays a crucial role on both purine and pyrimidine metabolism; allantoinase 553607..554968 Escherichia coli IAI1 7126765 YP_002385990.1 CDS ybbY NC_011741.1 555025 556326 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative purine permease YbbY 555025..556326 Escherichia coli IAI1 7125746 YP_002385991.1 CDS glxK NC_011741.1 556348 557493 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20069628; Product type e : enzyme; glycerate kinase II 556348..557493 Escherichia coli IAI1 7126766 YP_002385992.1 CDS ylbA NC_011741.1 557622 558407 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(557622..558407) Escherichia coli IAI1 7128356 YP_002385993.1 CDS allC NC_011741.1 558418 559653 R allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase complement(558418..559653) Escherichia coli IAI1 7126657 YP_002385994.1 CDS allD NC_011741.1 559675 560724 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12460564, 20069628, 69151449; Product type e : enzyme; ureidoglycolate dehydrogenase complement(559675..560724) Escherichia coli IAI1 7125747 YP_002385995.1 CDS fdrA NC_011741.1 561041 562708 D multicopy suppressor of dominant negative ftsH mutations; membrane protein FdrA 561041..562708 Escherichia coli IAI1 7125748 YP_002385996.1 CDS ylbE NC_011741.1 562718 563977 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 562718..563977 Escherichia coli IAI1 7127081 YP_002385997.1 CDS ylbF NC_011741.1 563988 564803 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 563988..564803 Escherichia coli IAI1 7126658 YP_002385998.1 CDS ybcF NC_011741.1 564800 565693 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2464576, 2644189, 7920643, 7940673, 7984428; Product type pe : putative enzyme; carbamate kinase 564800..565693 Escherichia coli IAI1 7126659 YP_002385999.1 CDS purK NC_011741.1 565830 566897 R With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit complement(565830..566897) Escherichia coli IAI1 7126767 YP_002386000.1 CDS purE NC_011741.1 566894 567403 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10074353, 8117684, 89123018, 89123019, 92287929, 10574791; Product type e : enzyme; N5-carboxyaminoimidazole ribonucleotide mutase complement(566894..567403) Escherichia coli IAI1 7126551 YP_002386001.1 CDS lpxH NC_011741.1 567521 568243 R catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase complement(567521..568243) Escherichia coli IAI1 7126548 YP_002386002.1 CDS ppiB NC_011741.1 568246 568740 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90272647, 91175755, 1606970, 1864365, 8601841, 9298646, 9600841; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase B complement(568246..568740) Escherichia coli IAI1 7127626 YP_002386003.1 CDS cysS NC_011741.1 568914 570299 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 568914..570299 Escherichia coli IAI1 7126133 YP_002386004.1 CDS ybcI NC_011741.1 570335 570856 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(570335..570856) Escherichia coli IAI1 7126901 YP_002386005.1 CDS ybcJ NC_011741.1 570964 571176 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12837795, 1748668, 7567469; Product type pr : putative regulator; hypothetical protein complement(570964..571176) Escherichia coli IAI1 7127369 YP_002386006.1 CDS folD NC_011741.1 571178 572044 R catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(571178..572044) Escherichia coli IAI1 7124782 YP_002386007.1 CDS sfmA NC_011741.1 572525 573067 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2890624; Product type ps : putative structure; putative fimbrial-like adhesin protein 572525..573067 Escherichia coli IAI1 7127262 YP_002386008.1 CDS sfmC NC_011741.1 573287 573979 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15372038, 2553674; Product type f : factor; pilin chaperone, periplasmic 573287..573979 Escherichia coli IAI1 7127916 YP_002386009.1 CDS sfmD NC_011741.1 574010 576619 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1970114; Product type pf : putative factor; putative outer membrane export usher protein 574010..576619 Escherichia coli IAI1 7127917 YP_002386010.1 CDS sfmH NC_011741.1 576662 577639 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein 576662..577639 Escherichia coli IAI1 7127918 YP_002386011.1 CDS sfmF NC_011741.1 577650 578165 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2890624; Product type ps : putative structure; putative fimbrial protein 577650..578165 Escherichia coli IAI1 7127920 YP_002386012.1 CDS fimZ NC_011741.1 578168 578800 R activates the production of the major fimbrae protein FimA; transcriptional regulator FimZ complement(578168..578800) Escherichia coli IAI1 7127919 YP_002386013.1 CDS ECIAI1_0538 NC_011741.1 579049 579171 R Evidence 6 : Doubtful CDS; hypothetical protein complement(579049..579171) Escherichia coli IAI1 7128049 YP_002386014.1 CDS envY NC_011741.1 579165 579926 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6317653, 2536924; Product type r : regulator; DNA-binding transcriptional activator of porin biosynthesis complement(579165..579926) Escherichia coli IAI1 7127033 YP_002386015.1 CDS ybcH NC_011741.1 580109 580999 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(580109..580999) Escherichia coli IAI1 7125076 YP_002386016.1 CDS nfrA NC_011741.1 581000 583972 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89359086, 94042873, 94042874; Product type m : membrane component; bacteriophage N4 receptor, outer membrane subunit complement(581000..583972) Escherichia coli IAI1 7126768 YP_002386017.1 CDS nfrB NC_011741.1 583959 586196 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89359086, 94042873, 94042874; Product type m : membrane component; bacteriophage N4 adsorption protein B complement(583959..586196) Escherichia coli IAI1 7127870 YP_002386018.1 CDS yhhI NC_011741.1 586465 587601 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype; putative transposase complement(586465..587601) Escherichia coli IAI1 7127871 YP_002386019.1 CDS ECIAI1_0545 NC_011741.1 588095 588562 R Evidence 6 : Doubtful CDS; hypothetical protein complement(588095..588562) Escherichia coli IAI1 7127143 YP_002386020.1 CDS ECIAI1_0546 NC_011741.1 588837 589235 R Evidence 6 : Doubtful CDS; hypothetical protein complement(588837..589235) Escherichia coli IAI1 7127034 YP_002386021.1 CDS ECIAI1_0547 NC_011741.1 589204 594003 R Evidence 2b : Function of strongly homologous gene; PubMedId : 1766878, 2644231, 2403547, 7934896; Rhs core protein with extension complement(589204..594003) Escherichia coli IAI1 7127035 YP_002386022.1 CDS ECIAI1_0548 NC_011741.1 594023 594484 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(594023..594484) Escherichia coli IAI1 7127036 YP_002386023.1 CDS ECIAI1_0549 NC_011741.1 594512 596413 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9696756, 8557353; putative Rhs element Vgr protein complement(594512..596413) Escherichia coli IAI1 7127037 YP_002386024.1 CDS cusS NC_011741.1 597150 598610 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 11283292, 11399769; Product type r : regulator; sensor kinase CusS complement(597150..598610) Escherichia coli IAI1 7127038 YP_002386025.1 CDS cusR NC_011741.1 598588 599271 R response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR complement(598588..599271) Escherichia coli IAI1 7126864 YP_002386026.1 CDS cusC NC_011741.1 599428 600810 D with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 599428..600810 Escherichia coli IAI1 7126863 YP_002386027.1 CDS cusF NC_011741.1 600834 601166 D Evidence 2b : Function of strongly homologous gene; PubMedId : 21125583, 11283292, 11399769, 12813074; Product type f : factor; periplasmic copper-binding protein 600834..601166 Escherichia coli IAI1 7126861 YP_002386028.1 CDS cusB NC_011741.1 601182 602405 D with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB 601182..602405 Escherichia coli IAI1 7126862 YP_002386029.1 CDS cusA NC_011741.1 602417 605560 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 21125583, 21178899, 21450803, 11399769, 12813074, 1711024, 7984428; Product type t : transporter; copper/silver efflux system, membrane component 602417..605560 Escherichia coli IAI1 7126860 YP_002386030.1 CDS pheP NC_011741.1 605662 607038 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91267923, 94042931, 8626334; Product type t : transporter; phenylalanine transporter 605662..607038 Escherichia coli IAI1 7126859 YP_002386031.1 CDS ybdG NC_011741.1 607106 608353 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein complement(607106..608353) Escherichia coli IAI1 7124195 YP_002386032.1 CDS nfnB NC_011741.1 608461 609114 R catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase complement(608461..609114) Escherichia coli IAI1 7124791 YP_002386033.1 CDS ybdF NC_011741.1 609208 609576 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(609208..609576) Escherichia coli IAI1 7127868 YP_002386034.1 CDS ybdJ NC_011741.1 609641 609889 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(609641..609889) Escherichia coli IAI1 7124790 YP_002386035.1 CDS ybdK NC_011741.1 609955 611073 R ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase complement(609955..611073) Escherichia coli IAI1 7124793 YP_002386036.1 CDS hokE NC_011741.1 611515 611667 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99291074; Product type f : factor; toxic polypeptide, small 611515..611667 Escherichia coli IAI1 7124794 YP_002386037.1 CDS ECIAI1_0564 NC_011741.1 611919 612170 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10361310; Product type pm : putative membrane component; putative small toxic membrane polypeptide HokE-like protein (partial) 611919..612170 Escherichia coli IAI1 7125290 YP_002386038.1 CDS entD NC_011741.1 612292 612921 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89313305, 90132534, 91035252, 8939709, 9214294; Product type e : enzyme; phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex complement(612292..612921) Escherichia coli IAI1 7127039 YP_002386039.1 CDS fepA NC_011741.1 613087 615327 R Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA complement(613087..615327) Escherichia coli IAI1 7125071 YP_002386040.1 CDS fes NC_011741.1 615648 616772 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92291125, 94198561, 2974033; Product type e : enzyme; enterobactin/ferric enterobactin esterase 615648..616772 Escherichia coli IAI1 7127087 YP_002386041.1 CDS ybdZ NC_011741.1 616775 616993 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 616775..616993 Escherichia coli IAI1 7127093 YP_002386042.1 CDS entF NC_011741.1 616990 620871 D with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 616990..620871 Escherichia coli IAI1 7124798 YP_002386043.1 CDS fepE NC_011741.1 621087 622220 D part of the ferric enterobactin transport system; necessary for enetrobactin uptake; ferric enterobactin transport protein FepE 621087..622220 Escherichia coli IAI1 7125073 YP_002386044.1 CDS fepC NC_011741.1 622217 623032 R with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein complement(622217..623032) Escherichia coli IAI1 7127091 YP_002386045.1 CDS fepG NC_011741.1 623029 624021 R with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease complement(623029..624021) Escherichia coli IAI1 7127089 YP_002386046.1 CDS fepD NC_011741.1 624018 625022 R with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein complement(624018..625022) Escherichia coli IAI1 7127092 YP_002386047.1 CDS ybdA NC_011741.1 625133 626383 D protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 625133..626383 Escherichia coli IAI1 7127090 YP_002386048.1 CDS fepB NC_011741.1 626387 627343 R with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein complement(626387..627343) Escherichia coli IAI1 7124787 YP_002386049.1 CDS entC NC_011741.1 627718 628893 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89123153, 90165423, 90241936, 2110093, 2139473; Product type e : enzyme; isochorismate synthase 1 627718..628893 Escherichia coli IAI1 7127088 YP_002386050.1 CDS entE NC_011741.1 628903 630513 D bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 628903..630513 Escherichia coli IAI1 7125070 YP_002386051.1 CDS entB NC_011741.1 630527 631384 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20183918, 90241937, 91035252, 9485415, 97361959, 2521621, 2521622; Product type e : enzyme; isochorismatase 630527..631384 Escherichia coli IAI1 7125072 YP_002386052.1 CDS entA NC_011741.1 631384 632130 D catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 631384..632130 Escherichia coli IAI1 7125069 YP_002386053.1 CDS ybdB NC_011741.1 632133 632546 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2521621, 2521622, 15808744; Product type pe : putative enzyme; hypothetical protein 632133..632546 Escherichia coli IAI1 7125068 YP_002386054.1 CDS cstA NC_011741.1 632727 634832 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91162636, 2521622; Product type pf : putative factor; carbon starvation protein 632727..634832 Escherichia coli IAI1 7124788 YP_002386055.1 CDS ybdD NC_011741.1 635014 635211 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 635014..635211 Escherichia coli IAI1 7126856 YP_002386056.1 CDS ybdH NC_011741.1 635221 636309 R member of the iron-containing alcohol dehydrogenase family; unknown function; hypothetical protein complement(635221..636309) Escherichia coli IAI1 7124789 YP_002386057.1 CDS ybdL NC_011741.1 636418 637578 D catalyzes the transfer of an amino moiety; putative aminotransferase 636418..637578 Escherichia coli IAI1 7124792 YP_002386058.1 CDS ibrB NC_011741.1 637579 638208 R Evidence 2b : Function of strongly homologous gene; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator complement(637579..638208) Escherichia coli IAI1 7124795 YP_002386059.1 CDS ibrA NC_011741.1 638181 639401 R Evidence 2b : Function of strongly homologous gene; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator complement(638181..639401) Escherichia coli IAI1 7126042 YP_002386060.1 CDS ybdO NC_011741.1 639548 640450 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator, LysR-type complement(639548..640450) Escherichia coli IAI1 7126041 YP_002386061.1 CDS dsbG NC_011741.1 640659 641405 R Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase complement(640659..641405) Escherichia coli IAI1 7124796 YP_002386062.1 CDS ahpC NC_011741.1 641777 642340 D with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase subunit C 641777..642340 Escherichia coli IAI1 7124865 YP_002386063.1 CDS ahpF NC_011741.1 642469 644034 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89197774, 1592833; Product type e : enzyme; alkyl hydroperoxide reductase, F52a subunit 642469..644034 Escherichia coli IAI1 7125736 YP_002386064.1 CDS uspG NC_011741.1 644155 644583 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 12071968; Product type f : factor; universal stress protein UP12 complement(644155..644583) Escherichia coli IAI1 7125737 YP_002386065.1 CDS ybdR NC_011741.1 644804 646042 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8185833; Product type pe : putative enzyme; putative oxidoreductase 644804..646042 Escherichia coli IAI1 7125553 YP_002386066.1 CDS rnk NC_011741.1 646273 646683 R Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator complement(646273..646683) Escherichia coli IAI1 7124797 YP_002386067.1 CDS rna NC_011741.1 646913 647719 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90151658, 90264307, 2253883, 8188249; Product type e : enzyme; ribonuclease I complement(646913..647719) Escherichia coli IAI1 7125024 YP_002386068.1 CDS citT NC_011741.1 647833 649296 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9696764; Product type t : transporter; citrate:succinate antiporter complement(647833..649296) Escherichia coli IAI1 7125015 YP_002386069.1 CDS citG NC_011741.1 649347 650225 R catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase complement(649347..650225) Escherichia coli IAI1 7126327 YP_002386070.1 CDS citX NC_011741.1 650200 650751 R 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo- citrate lyase complement(650200..650751) Escherichia coli IAI1 7126326 YP_002386071.1 CDS citF NC_011741.1 650755 652287 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase, citrate-ACP transferase alpha subunit complement(650755..652287) Escherichia coli IAI1 7126328 YP_002386072.1 CDS citE NC_011741.1 652298 653206 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase, citryl-ACP lyase subunit beta complement(652298..653206) Escherichia coli IAI1 7126325 YP_002386073.1 CDS citD NC_011741.1 653203 653499 R acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma complement(653203..653499) Escherichia coli IAI1 7126324 YP_002386074.1 CDS citC NC_011741.1 653514 654572 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase synthetase complement(653514..654572) Escherichia coli IAI1 7126323 YP_002386075.1 CDS citA NC_011741.1 654952 656610 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11889485, 21885746, 9701802; Product type r : regulator; sensory histidine kinase in two-component regulatory system with citB 654952..656610 Escherichia coli IAI1 7126322 YP_002386076.1 CDS dpiA NC_011741.1 656579 657259 D regulates the expression of citAB in citrate fermentation; two-component response regulator DpiA 656579..657259 Escherichia coli IAI1 7126320 YP_002386077.1 CDS dcuC NC_011741.1 657300 658685 R responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC complement(657300..658685) Escherichia coli IAI1 7126321 YP_002386078.1 CDS pagP NC_011741.1 659274 659834 D catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 659274..659834 Escherichia coli IAI1 7126929 YP_002386079.1 CDS cspE NC_011741.1 660009 660218 D member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 660009..660218 Escherichia coli IAI1 7126363 YP_002386080.1 CDS crcB NC_011741.1 660273 660656 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(660273..660656) Escherichia coli IAI1 7125935 YP_002386081.1 CDS ybeM NC_011741.1 660974 661537 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amidase 660974..661537 Escherichia coli IAI1 7126364 YP_002386082.1 CDS tatE NC_011741.1 661666 661869 D TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein E 661666..661869 Escherichia coli IAI1 7124804 YP_002386083.1 CDS lipA NC_011741.1 661970 662935 R catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase complement(661970..662935) Escherichia coli IAI1 7126218 YP_002386084.1 CDS ybeF NC_011741.1 663144 664097 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12218038; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(663144..664097) Escherichia coli IAI1 7126421 YP_002386085.1 CDS lipB NC_011741.1 664356 664997 R lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B complement(664356..664997) Escherichia coli IAI1 7124802 YP_002386086.1 CDS ybeD NC_011741.1 665098 665361 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8444795; hypothetical protein complement(665098..665361) Escherichia coli IAI1 7126422 YP_002386087.1 CDS dacA NC_011741.1 665472 666683 R penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase fraction A complement(665472..666683) Escherichia coli IAI1 7124801 YP_002386088.1 CDS rlpA NC_011741.1 666822 667910 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88058785, 2644207; Product type lp : lipoprotein; rare lipoprotein A complement(666822..667910) Escherichia coli IAI1 7126908 YP_002386089.1 CDS mrdB NC_011741.1 667921 669033 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89123070, 90036736, 91072213, 3316191; Product type cp : cell process; cell wall shape-determining protein complement(667921..669033) Escherichia coli IAI1 7125007 YP_002386090.1 CDS mrdA NC_011741.1 669036 670937 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86196149, 87030266, 89174517, 2644207; Product type e : enzyme; penicillin-binding protein 2 complement(669036..670937) Escherichia coli IAI1 7124473 YP_002386091.1 CDS ybeA NC_011741.1 670968 671435 R SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(670968..671435) Escherichia coli IAI1 7124472 YP_002386092.1 CDS ybeB NC_011741.1 671439 671756 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(671439..671756) Escherichia coli IAI1 7124799 YP_002386093.1 CDS phpB NC_011741.1 672016 672627 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7929373; Product type pe : putative enzyme; putative phosphatase with phosphoglycerate mutase domain complement(672016..672627) Escherichia coli IAI1 7124800 YP_002386094.1 CDS nadD NC_011741.1 672651 673292 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(672651..673292) Escherichia coli IAI1 7124223 YP_002386095.1 CDS holA NC_011741.1 673294 674325 R required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta complement(673294..674325) Escherichia coli IAI1 7124514 YP_002386096.1 CDS rlpB NC_011741.1 674325 674906 R rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB complement(674325..674906) Escherichia coli IAI1 7125291 YP_002386097.1 CDS leuS NC_011741.1 674921 677503 R leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase complement(674921..677503) Escherichia coli IAI1 7125008 YP_002386098.1 CDS ybeL NC_011741.1 677738 678220 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11373298, 12105207, 3320963, 7567469; hypothetical protein 677738..678220 Escherichia coli IAI1 7126413 YP_002386099.1 CDS ybeQ NC_011741.1 678290 679267 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(678290..679267) Escherichia coli IAI1 7124803 YP_002386100.1 CDS ybeR NC_011741.1 679431 680138 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 679431..680138 Escherichia coli IAI1 7124805 YP_002386101.1 CDS djlB NC_011741.1 680135 681562 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12183460, 10574456; Product type pf : putative factor; putative DnaJ-class chaperone 680135..681562 Escherichia coli IAI1 7124806 YP_002386102.1 CDS ybeT NC_011741.1 681572 682126 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(681572..682126) Escherichia coli IAI1 7124594 YP_002386103.1 CDS ybeU NC_011741.1 682227 682934 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 682227..682934 Escherichia coli IAI1 7124807 YP_002386104.1 CDS djlC NC_011741.1 682931 684382 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12183460, 12054669; Product type f : factor; Hsc56 co-chaperone of HscC 682931..684382 Escherichia coli IAI1 7124808 YP_002386105.1 CDS hscC NC_011741.1 684442 686112 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12183460, 14734171, 22055095, 9735342; Product type f : factor; Hsp70 family chaperone Hsc62, binds to RpoD and inhibits transcription complement(684442..686112) Escherichia coli IAI1 7124595 YP_002386106.1 CDS rihA NC_011741.1 686196 687131 R Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 complement(686196..687131) Escherichia coli IAI1 7125311 YP_002386107.1 CDS gltL NC_011741.1 687249 687974 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate ABC transporter ATP-binding protein complement(687249..687974) Escherichia coli IAI1 7124998 YP_002386108.1 CDS gltK NC_011741.1 687974 688648 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate ABC transporter membrane protein complement(687974..688648) Escherichia coli IAI1 7128352 YP_002386109.1 CDS gltJ NC_011741.1 688648 689388 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate ABC transporter membrane protein complement(688648..689388) Escherichia coli IAI1 7128351 YP_002386110.1 CDS gltI NC_011741.1 689558 690466 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1091636, 1091635, 10493123, 8740179, 10972807; Product type t : transporter; glutamate and aspartate transporter subunit complement(689558..690466) Escherichia coli IAI1 7125489 YP_002386111.1 CDS ECIAI1_0640 NC_011741.1 690921 692798 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 690921..692798 Escherichia coli IAI1 7128349 YP_002386112.1 CDS lnt NC_011741.1 692876 694414 R Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase complement(692876..694414) Escherichia coli IAI1 7127040 YP_002386113.1 CDS ybeX NC_011741.1 694439 695317 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1779764; Product type pt : putative transporter; hypothetical protein complement(694439..695317) Escherichia coli IAI1 7126432 YP_002386114.1 CDS ybeY NC_011741.1 695407 695874 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16511207; Product type pe : putative enzyme; putative metalloprotease complement(695407..695874) Escherichia coli IAI1 7124809 YP_002386115.1 CDS ybeZ NC_011741.1 695871 696950 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12762842; Product type pe : putative enzyme; hypothetical protein complement(695871..696950) Escherichia coli IAI1 7124810 YP_002386116.1 CDS miaB NC_011741.1 697064 698488 R catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase complement(697064..698488) Escherichia coli IAI1 7124811 YP_002386117.1 CDS ubiF NC_011741.1 698634 699809 D catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 698634..699809 Escherichia coli IAI1 7124271 YP_002386119.1 CDS ECIAI1_0650 NC_011741.1 700628 700810 R hypothetical protein complement(700628..700810) Escherichia coli IAI1 7128061 YP_002386120.1 CDS asnB NC_011741.1 701047 702711 R functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B complement(701047..702711) Escherichia coli IAI1 7127042 YP_002386121.1 CDS nagD NC_011741.1 702968 703720 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16430214, 89343637; Product type e : enzyme; UMP phosphatase complement(702968..703720) Escherichia coli IAI1 7126262 YP_002386122.1 CDS nagC NC_011741.1 703768 704988 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15066032, 90136533, 91171292, 92114782, 92356048, 2190615, 2668691, 7545108; Product type r : regulator; DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine complement(703768..704988) Escherichia coli IAI1 7124520 YP_002386123.1 CDS nagA NC_011741.1 704997 706145 R catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase complement(704997..706145) Escherichia coli IAI1 7124519 YP_002386124.1 CDS nagB NC_011741.1 706205 707005 R catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase complement(706205..707005) Escherichia coli IAI1 7124517 YP_002386125.1 CDS nagE NC_011741.1 707338 709284 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunits IIABC 707338..709284 Escherichia coli IAI1 7124518 YP_002386126.1 CDS glnS NC_011741.1 709487 711151 D catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 709487..711151 Escherichia coli IAI1 7124521 YP_002386127.1 CDS ybfM NC_011741.1 711597 713003 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2118530, 9636669; Product type pt : putative transporter; putative outer membrane porin 711597..713003 Escherichia coli IAI1 7128331 YP_002386128.1 CDS ybfN NC_011741.1 713053 713379 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 713053..713379 Escherichia coli IAI1 7124816 YP_002386129.1 CDS fur NC_011741.1 713463 713909 R negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator complement(713463..713909) Escherichia coli IAI1 7124817 YP_002386130.1 CDS ECIAI1_0662 NC_011741.1 713954 714208 D Evidence 6 : Doubtful CDS; hypothetical protein 713954..714208 Escherichia coli IAI1 7128255 YP_002386131.1 CDS fldA NC_011741.1 714198 714728 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA complement(714198..714728) Escherichia coli IAI1 7127043 YP_002386132.1 CDS ybfE NC_011741.1 714868 715161 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20223640, 12427949; Product type cp : cell process; LexA regulated protein complement(714868..715161) Escherichia coli IAI1 7127209 YP_002386133.1 CDS ybfF NC_011741.1 715301 716065 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme; hypothetical protein complement(715301..716065) Escherichia coli IAI1 7124814 YP_002386134.1 CDS seqA NC_011741.1 716250 716795 D negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 716250..716795 Escherichia coli IAI1 7124815 YP_002386135.1 CDS pgm NC_011741.1 716821 718461 D catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 716821..718461 Escherichia coli IAI1 7127907 YP_002386136.1 CDS potE NC_011741.1 718517 719836 R catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter complement(718517..719836) Escherichia coli IAI1 7124188 YP_002386137.1 CDS speF NC_011741.1 719833 722031 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92041955; Product type e : enzyme; ornithine decarboxylase complement(719833..722031) Escherichia coli IAI1 7126117 YP_002386138.1 CDS kdpE NC_011741.1 722721 723398 R response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; DNA-binding transcriptional activator KdpE complement(722721..723398) Escherichia coli IAI1 7127959 YP_002386139.1 CDS kdpD NC_011741.1 723395 726079 R sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; sensor protein KdpD complement(723395..726079) Escherichia coli IAI1 7126377 YP_002386140.1 CDS kdpC NC_011741.1 726072 726644 R One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C complement(726072..726644) Escherichia coli IAI1 7126376 YP_002386141.1 CDS kdpB NC_011741.1 726653 728701 R One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B complement(726653..728701) Escherichia coli IAI1 7126375 YP_002386142.1 CDS kdpA NC_011741.1 728724 730397 R catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A complement(728724..730397) Escherichia coli IAI1 7126374 YP_002386143.1 CDS ybfA NC_011741.1 730799 731005 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 730799..731005 Escherichia coli IAI1 7126373 YP_002386144.1 CDS rhsC NC_011741.1 731248 735441 D Evidence 2b : Function of strongly homologous gene; PubMedId : 98361897, 2403547, 2644231, 7934896, 8387990; Product type h : extrachromosomal origin; rhsC element core protein RshC 731248..735441 Escherichia coli IAI1 7124812 YP_002386145.1 CDS ybfO NC_011741.1 735885 737318 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 735885..737318 Escherichia coli IAI1 7124985 YP_002386146.1 CDS ybfC NC_011741.1 737315 737884 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 737315..737884 Escherichia coli IAI1 7124818 YP_002386147.1 CDS ybgA NC_011741.1 739399 739908 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6325460, 8387990; hypothetical protein 739399..739908 Escherichia coli IAI1 7127145 YP_002386148.1 CDS phr NC_011741.1 739905 741323 D UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 739905..741323 Escherichia coli IAI1 7124819 YP_002386149.1 CDS ybgH NC_011741.1 741365 742846 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15175316; Product type pt : putative transporter; putative transporter complement(741365..742846) Escherichia coli IAI1 7124224 YP_002386150.1 CDS ybgI NC_011741.1 743117 743860 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14519207; putative hydrolase-oxidase 743117..743860 Escherichia coli IAI1 7124823 YP_002386151.1 CDS ybgJ NC_011741.1 743883 744539 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase subunit 743883..744539 Escherichia coli IAI1 7124824 YP_002386152.1 CDS ybgK NC_011741.1 744533 745465 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase subunit 744533..745465 Escherichia coli IAI1 7124825 YP_002386153.1 CDS ybgL NC_011741.1 745455 746189 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1729609; Product type pe : putative enzyme; LamB/YcsF family protein 745455..746189 Escherichia coli IAI1 7124826 YP_002386154.1 CDS nei NC_011741.1 746225 747016 D 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 746225..747016 Escherichia coli IAI1 7124827 YP_002386155.1 CDS abrB NC_011741.1 747013 748059 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8002588; Product type ph : phenotype; hypothetical protein complement(747013..748059) Escherichia coli IAI1 7127865 YP_002386156.1 CDS ybgO NC_011741.1 748211 749272 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(748211..749272) Escherichia coli IAI1 7125689 YP_002386157.1 CDS ybgP NC_011741.1 749269 750024 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10049807; Product type pf : putative factor; putative exported chaperone, PapD family complement(749269..750024) Escherichia coli IAI1 7124828 YP_002386158.1 CDS ybgQ NC_011741.1 750015 752516 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(750015..752516) Escherichia coli IAI1 7124829 YP_002386159.1 CDS ECIAI1_0693 NC_011741.1 752525 753091 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative fimbrial-like adhesin protein complement(752525..753091) Escherichia coli IAI1 7124830 YP_002386160.1 CDS gltA NC_011741.1 753482 754765 R type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase complement(753482..754765) Escherichia coli IAI1 7127044 YP_002386161.1 CDS sdhC NC_011741.1 755474 755863 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6237244, 89076355, 89123360, 9521736, 99414342, 11259408, 3309132, 6383359, 9822661; Product type m : membrane component; succinate dehydrogenase cytochrome b556 large membrane subunit 755474..755863 Escherichia coli IAI1 7128346 YP_002386162.1 CDS sdhD NC_011741.1 755857 756204 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82124790, 89076355, 9521736, 99414342, 6383359; Product type m : membrane component; succinate dehydrogenase cytochrome b556 small membrane subunit 755857..756204 Escherichia coli IAI1 7124688 YP_002386163.1 CDS sdhA NC_011741.1 756204 757970 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 756204..757970 Escherichia coli IAI1 7124689 YP_002386164.1 CDS sdhB NC_011741.1 757986 758702 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 757986..758702 Escherichia coli IAI1 7124686 YP_002386165.1 CDS sucA NC_011741.1 758903 761704 D SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 758903..761704 Escherichia coli IAI1 7124687 YP_002386166.1 CDS sucB NC_011741.1 761719 762936 D component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 761719..762936 Escherichia coli IAI1 7126188 YP_002386167.1 CDS sucC NC_011741.1 763030 764196 D catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 763030..764196 Escherichia coli IAI1 7126189 YP_002386168.1 CDS sucD NC_011741.1 764196 765065 D Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 764196..765065 Escherichia coli IAI1 7126190 YP_002386169.1 CDS mngR NC_011741.1 765169 765891 R regulates the succiny-lCoA synthetase operon; DNA-binding transcriptional repressor MngR complement(765169..765891) Escherichia coli IAI1 7124650 YP_002386170.1 CDS mngA NC_011741.1 766000 767976 D involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC 766000..767976 Escherichia coli IAI1 7124287 YP_002386171.1 CDS mngB NC_011741.1 767994 770627 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14645248, 9063979; Product type e : enzyme; alpha-mannosidase 767994..770627 Escherichia coli IAI1 7124285 YP_002386172.1 CDS ECIAI1_0706 NC_011741.1 770652 770879 D Evidence 6 : Doubtful CDS; hypothetical protein 770652..770879 Escherichia coli IAI1 7124286 YP_002386173.1 CDS cydA NC_011741.1 771474 773042 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87299685, 89255232, 91035243, 1689724, 1724280, 2843510, 3138232; Product type c : carrier; cytochrome d terminal oxidase subunit I 771474..773042 Escherichia coli IAI1 7126930 YP_002386174.1 CDS cydB NC_011741.1 773058 774197 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87299685, 89255232, 91035243, 2843510, 3138232; Product type c : carrier; cytochrome d terminal oxidase subunit II 773058..774197 Escherichia coli IAI1 7126874 YP_002386175.1 CDS ybgE NC_011741.1 774325 774618 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 774325..774618 Escherichia coli IAI1 7126875 YP_002386176.1 CDS ybgC NC_011741.1 774768 775172 D catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase YbgC 774768..775172 Escherichia coli IAI1 7124821 YP_002386177.1 CDS tolQ NC_011741.1 775169 775861 D membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 775169..775861 Escherichia coli IAI1 7124820 YP_002386178.1 CDS tolR NC_011741.1 775865 776293 D membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 775865..776293 Escherichia coli IAI1 7127461 YP_002386179.1 CDS tolA NC_011741.1 776358 777623 D inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 776358..777623 Escherichia coli IAI1 7127462 YP_002386180.1 CDS tolB NC_011741.1 777756 779048 D forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 777756..779048 Escherichia coli IAI1 7127458 YP_002386181.1 CDS pal NC_011741.1 779083 779604 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11790745, 87133578, 92244043, 99403391, 11173492, 2687247; Product type lp : lipoprotein; peptidoglycan-associated outer membrane lipoprotein 779083..779604 Escherichia coli IAI1 7127459 YP_002386182.1 CDS ybgF NC_011741.1 779614 780405 D periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 779614..780405 Escherichia coli IAI1 7124149 YP_002386183.1 CDS nadA NC_011741.1 781974 783017 D 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 781974..783017 Escherichia coli IAI1 7127988 YP_002386184.1 CDS pnuC NC_011741.1 783055 783774 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 219824, 90330519; Product type t : transporter; nicotinamide mononucleotide transporter 783055..783774 Escherichia coli IAI1 7124511 YP_002386185.1 CDS zitB NC_011741.1 783771 784712 R involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB complement(783771..784712) Escherichia coli IAI1 7126110 YP_002386186.1 CDS ybgS NC_011741.1 784826 785206 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(784826..785206) Escherichia coli IAI1 7128125 YP_002386187.1 CDS aroG NC_011741.1 785522 786574 D catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 785522..786574 Escherichia coli IAI1 7124831 YP_002386188.1 CDS gpmA NC_011741.1 786733 787485 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(786733..787485) Escherichia coli IAI1 7125808 YP_002386189.1 CDS galM NC_011741.1 787690 788730 R catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase complement(787690..788730) Escherichia coli IAI1 7128458 YP_002386190.1 CDS galK NC_011741.1 788724 789872 R catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase complement(788724..789872) Escherichia coli IAI1 7128271 YP_002386191.1 CDS galT NC_011741.1 789876 790922 R catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase complement(789876..790922) Escherichia coli IAI1 7128270 YP_002386192.1 CDS galE NC_011741.1 790932 791948 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89274199, 92253563, 92338916, 3022232, 6301942, 8564363, 8611559, 8931134, 9174344, 9271499, 9708982; Product type e : enzyme; UDP-galactose-4-epimerase complement(790932..791948) Escherichia coli IAI1 7128275 YP_002386193.1 CDS modF NC_011741.1 792210 793682 R contains 2 ATP-binding cassettes; involved in the transport of molybdenum; putative molybdenum transport ATP-binding protein ModF complement(792210..793682) Escherichia coli IAI1 7128268 YP_002386194.1 CDS modE NC_011741.1 793750 794538 R represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE complement(793750..794538) Escherichia coli IAI1 7124301 YP_002386195.1 CDS ybhT NC_011741.1 794667 794816 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 794667..794816 Escherichia coli IAI1 7124300 YP_002386196.1 CDS modA NC_011741.1 794983 795756 D with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein 794983..795756 Escherichia coli IAI1 7124850 YP_002386197.1 CDS modB NC_011741.1 795756 796445 D part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 795756..796445 Escherichia coli IAI1 7124297 YP_002386198.1 CDS modC NC_011741.1 796448 797506 D Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 796448..797506 Escherichia coli IAI1 7124298 YP_002386199.1 CDS ybhA NC_011741.1 797507 798325 R YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase complement(797507..798325) Escherichia coli IAI1 7124299 YP_002386200.1 CDS pgl NC_011741.1 798480 799475 D catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 798480..799475 Escherichia coli IAI1 7124832 YP_002386201.1 CDS ybhD NC_011741.1 799516 800532 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(799516..800532) Escherichia coli IAI1 7124187 YP_002386202.1 CDS ECIAI1_0737 NC_011741.1 800387 800536 D hypothetical protein 800387..800536 Escherichia coli IAI1 7124835 YP_002386203.1 CDS ybhH NC_011741.1 800653 801705 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 800653..801705 Escherichia coli IAI1 7126931 YP_002386204.1 CDS ybhI NC_011741.1 801781 803214 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative anion transporter 801781..803214 Escherichia coli IAI1 7124838 YP_002386205.1 CDS ECIAI1_0740 NC_011741.1 803115 803285 D Evidence 6 : Doubtful CDS; hypothetical protein 803115..803285 Escherichia coli IAI1 7124839 YP_002386206.1 CDS ybhJ NC_011741.1 803397 805658 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11782506; Product type pe : putative enzyme; hypothetical protein 803397..805658 Escherichia coli IAI1 7126932 YP_002386207.1 CDS ybhC NC_011741.1 805892 807175 R outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family; putative pectinesterase complement(805892..807175) Escherichia coli IAI1 7124840 YP_002386208.1 CDS int NC_011741.1 807310 808380 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6446713; Product type h : extrachromosomal origin; Integrase from phage complement(807310..808380) Escherichia coli IAI1 7124834 YP_002386209.1 CDS ECIAI1_0745 NC_011741.1 808675 808842 R Evidence 6 : Doubtful CDS; hypothetical protein complement(808675..808842) Escherichia coli IAI1 7126071 YP_002386210.1 CDS ECIAI1_0746 NC_011741.1 808871 809704 R Evidence 2b : Function of strongly homologous gene; PubMedId : 1718819, 7737514; Product type pe : putative enzyme; transposase, ORF B, IS3 family, IS407 group complement(808871..809704) Escherichia coli IAI1 7126933 YP_002386211.1 CDS ECIAI1_0747 NC_011741.1 809728 809991 R Evidence 2b : Function of strongly homologous gene; PubMedId : 15126494, 7737514; Product type pe : putative enzyme; transposase, ORF A, IS3 family, IS407 group complement(809728..809991) Escherichia coli IAI1 7126934 YP_002386212.1 CDS ECIAI1_0748 NC_011741.1 810227 810379 R hypothetical protein complement(810227..810379) Escherichia coli IAI1 7126935 YP_002386213.1 CDS ECIAI1_0749 NC_011741.1 810357 810641 R Evidence 6 : Doubtful CDS; hypothetical protein complement(810357..810641) Escherichia coli IAI1 7126936 YP_002386214.1 CDS ECIAI1_0750 NC_011741.1 810726 811301 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative DnaJ-class molecular chaperone with C-terminal Zn finger domain complement(810726..811301) Escherichia coli IAI1 7126937 YP_002386215.1 CDS ECIAI1_0751 NC_011741.1 811312 812109 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(811312..812109) Escherichia coli IAI1 7126938 YP_002386216.1 CDS ECIAI1_0752 NC_011741.1 812069 812476 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(812069..812476) Escherichia coli IAI1 7126939 YP_002386217.1 CDS ECIAI1_0753 NC_011741.1 812473 812694 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(812473..812694) Escherichia coli IAI1 7126940 YP_002386218.1 CDS ECIAI1_0754 NC_011741.1 812793 813074 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(812793..813074) Escherichia coli IAI1 7126941 YP_002386219.1 CDS ECIAI1_0756 NC_011741.1 813428 814108 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; exonuclease from phage origin complement(813428..814108) Escherichia coli IAI1 7126942 YP_002386220.1 CDS ECIAI1_0757 NC_011741.1 814105 814890 R Evidence 2b : Function of strongly homologous gene; PubMedId : 6458018, 6221115; Product type h : extrachromosomal origin; Recombination protein bet from phage origin complement(814105..814890) Escherichia coli IAI1 7126943 YP_002386221.1 CDS ECIAI1_0758 NC_011741.1 814896 815192 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative host-nuclease inhibitor protein Gam of bacteriophage complement(814896..815192) Escherichia coli IAI1 7126944 YP_002386222.1 CDS ECIAI1_0759 NC_011741.1 815269 815679 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative prophage Kil protein complement(815269..815679) Escherichia coli IAI1 7126945 YP_002386223.1 CDS ECIAI1_0760 NC_011741.1 815954 816466 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(815954..816466) Escherichia coli IAI1 7126946 YP_002386224.1 CDS ECIAI1_0761 NC_011741.1 816463 817602 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase m, neutral zinc metallopeptidases, zinc-binding site; protein complement(816463..817602) Escherichia coli IAI1 7126947 YP_002386225.1 CDS ECIAI1_0762 NC_011741.1 817732 818460 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Regulatory protein CI from bacteriophage origin complement(817732..818460) Escherichia coli IAI1 7126948 YP_002386226.1 CDS cro NC_011741.1 818529 818762 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; represror Cro 818529..818762 Escherichia coli IAI1 7126949 YP_002386227.1 CDS ECIAI1_0764 NC_011741.1 818787 819332 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 612476; Product type h : extrachromosomal origin; Regulatory protein CII from bacteriophage origin 818787..819332 Escherichia coli IAI1 7125913 YP_002386228.1 CDS ECIAI1_0765 NC_011741.1 819329 820348 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2995831; Product type h : extrachromosomal origin; Replication protein O frm phage origin 819329..820348 Escherichia coli IAI1 7126950 YP_002386229.1 CDS ECIAI1_0766 NC_011741.1 820345 821046 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative replication protein P of bacteriophage 820345..821046 Escherichia coli IAI1 7126951 YP_002386230.1 CDS ECIAI1_0767 NC_011741.1 821625 822377 D hypothetical protein 821625..822377 Escherichia coli IAI1 7126952 YP_002386231.1 CDS ECIAI1_0768 NC_011741.1 822389 822463 D putative inner membrane protein (fragment) 822389..822463 Escherichia coli IAI1 7126953 YP_002386232.1 CDS ECIAI1_0769 NC_011741.1 822634 823116 D hypothetical protein 822634..823116 Escherichia coli IAI1 7126954 YP_002386233.1 CDS ybcN NC_011741.1 823306 823761 D DLP12 prophage; hypothetical protein 823306..823761 Escherichia coli IAI1 7126955 YP_002386234.1 CDS ninE NC_011741.1 823761 823931 D DLP12 prophage; conserved protein similar to phage 82 and lambda proteins; prophage protein NinE 823761..823931 Escherichia coli IAI1 7124783 YP_002386235.1 CDS ybcO NC_011741.1 823924 824214 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 823924..824214 Escherichia coli IAI1 7127883 YP_002386236.1 CDS rusA NC_011741.1 824211 824573 D DLP12 prophage; Holliday junction resolvase; endodeoxyribonuclease RUS 824211..824573 Escherichia coli IAI1 7124784 YP_002386237.1 CDS ybcQ NC_011741.1 824796 825179 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8648624, 9278503; Product type pf : putative factor; putative antitermination protein Q-like protein; DLP12 prophage 824796..825179 Escherichia coli IAI1 7124635 YP_002386238.1 CDS nmpC NC_011741.1 825369 826466 R Evidence 2b : Function of strongly homologous gene; PubMedId : 3017988, 8057841; Product type m : membrane component; outer membrane porin; DLP12 prophage complement(825369..826466) Escherichia coli IAI1 7124785 YP_002386239.1 CDS essD NC_011741.1 827055 827270 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019562; Product type pe : putative enzyme; putative phage lysis protein S; DLP12 prophage 827055..827270 Escherichia coli IAI1 7127893 YP_002386240.1 CDS ybcS NC_011741.1 827270 827767 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3017988; Product type pe : putative enzyme; putative lysozyme; DLP12 prophage 827270..827767 Escherichia coli IAI1 7125090 YP_002386241.1 CDS rzpD NC_011741.1 827764 828225 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019562; Product type pe : putative enzyme; putative murein endopeptidase; DLP12 prophage 827764..828225 Escherichia coli IAI1 7124786 YP_002386242.1 CDS borD NC_011741.1 828257 828598 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 95173101; Product type pm : putative membrane component; putative lipoprotein; DLP12 prophage complement(828257..828598) Escherichia coli IAI1 7124667 YP_002386243.1 CDS nohB NC_011741.1 829496 830041 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92334985; Product type h : extrachromosomal origin; DNA packaging protein; DLP12 prophage 829496..830041 Escherichia coli IAI1 7127572 YP_002386244.1 CDS A NC_011741.1 830016 831941 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Terminase large subunit from bacteriophage origin 830016..831941 Escherichia coli IAI1 7127894 YP_002386245.1 CDS W NC_011741.1 831938 832144 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11302702; Product type h : extrachromosomal origin; Head-to-tail joining protein W (gpW) from bacteriophage origin 831938..832144 Escherichia coli IAI1 7125673 YP_002386246.1 CDS B NC_011741.1 832141 833742 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Portal protein; minor capsid protein 832141..833742 Escherichia coli IAI1 7125572 YP_002386247.1 CDS C NC_011741.1 833723 835042 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Minor capsid protein 833723..835042 Escherichia coli IAI1 7126285 YP_002386248.1 CDS D NC_011741.1 835046 835384 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Head decoration protein from bacteriophage origin 835046..835384 Escherichia coli IAI1 7124429 YP_002386249.1 CDS E NC_011741.1 835413 836465 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Major head coat protein from bacteriophage origin 835413..836465 Escherichia coli IAI1 7126906 YP_002386250.1 CDS fI NC_011741.1 836468 836902 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; DNA packaging protein from bacteriophage origin 836468..836902 Escherichia coli IAI1 7125037 YP_002386251.1 CDS fII NC_011741.1 836914 837267 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin; Tail attachment protein (Minor capsid protein FII) from bacteriophage origin 836914..837267 Escherichia coli IAI1 7127104 YP_002386252.1 CDS ECIAI1_0790 NC_011741.1 837279 837857 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein Z (GpZ) 837279..837857 Escherichia coli IAI1 7127108 YP_002386253.1 CDS ECIAI1_0791 NC_011741.1 837854 838249 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein U 837854..838249 Escherichia coli IAI1 7126956 YP_002386254.1 CDS ECIAI1_0792 NC_011741.1 838227 838997 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major tail protein V 838227..838997 Escherichia coli IAI1 7126957 YP_002386255.1 CDS ECIAI1_0793 NC_011741.1 839013 839435 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein G 839013..839435 Escherichia coli IAI1 7126958 YP_002386256.1 CDS ECIAI1_0794 NC_011741.1 839417 839851 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein T 839417..839851 Escherichia coli IAI1 7126959 YP_002386257.1 CDS ECIAI1_0795 NC_011741.1 839844 842423 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein H 839844..842423 Escherichia coli IAI1 7126960 YP_002386258.1 CDS ECIAI1_0796 NC_011741.1 842341 842499 D hypothetical protein 842341..842499 Escherichia coli IAI1 7126961 YP_002386259.1 CDS ECIAI1_0797 NC_011741.1 842420 842749 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein M 842420..842749 Escherichia coli IAI1 7126962 YP_002386260.1 CDS ECIAI1_0798 NC_011741.1 842749 843447 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein L 842749..843447 Escherichia coli IAI1 7126963 YP_002386261.1 CDS ECIAI1_0799 NC_011741.1 843453 844196 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber component K of prophage 843453..844196 Escherichia coli IAI1 7126964 YP_002386262.1 CDS ECIAI1_0800 NC_011741.1 844094 844765 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Tail assembly protein I 844094..844765 Escherichia coli IAI1 7126965 YP_002386263.1 CDS ECIAI1_0801 NC_011741.1 844826 848305 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J 844826..848305 Escherichia coli IAI1 7126966 YP_002386264.1 CDS ECIAI1_0802 NC_011741.1 848374 848973 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Lom-like outer membrane protein of phage origin 848374..848973 Escherichia coli IAI1 7126967 YP_002386265.1 CDS ECIAI1_0803 NC_011741.1 849032 852793 D hypothetical protein 849032..852793 Escherichia coli IAI1 7128622 YP_002386266.1 CDS ECIAI1_0804 NC_011741.1 853588 853755 R hypothetical protein complement(853588..853755) Escherichia coli IAI1 7128623 YP_002386267.1 CDS ECIAI1_0805 NC_011741.1 854470 855222 D putative AraC-type regulatory protein encoded in prophage CP-933H 854470..855222 Escherichia coli IAI1 7128624 YP_002386268.1 CDS ECIAI1_0806 NC_011741.1 855264 855629 R hypothetical protein complement(855264..855629) Escherichia coli IAI1 7128625 YP_002386269.1 CDS ybhB NC_011741.1 856325 856801 R YbhB; similar to rat and human kinase inhibitory proteins; putative kinase inhibitor protein complement(856325..856801) Escherichia coli IAI1 7126654 YP_002386270.1 CDS bioA NC_011741.1 856860 858149 R catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine--8-amino-7-oxononanoate transaminase complement(856860..858149) Escherichia coli IAI1 7124833 YP_002386271.1 CDS bioB NC_011741.1 858236 859276 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11834738, 12475249, 14704425, 14967041, 20250955, 89066784, 94170810, 94190882, 97382445, 11686925; Product type e : enzyme; biotin synthase 858236..859276 Escherichia coli IAI1 7124407 YP_002386272.1 CDS bioF NC_011741.1 859273 860427 D catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 859273..860427 Escherichia coli IAI1 7124408 YP_002386273.1 CDS bioC NC_011741.1 860414 861169 D putative methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 860414..861169 Escherichia coli IAI1 7124411 YP_002386274.1 CDS bioD NC_011741.1 861162 861839 D DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 861162..861839 Escherichia coli IAI1 7124409 YP_002386275.1 CDS uvrB NC_011741.1 862418 864439 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 862418..864439 Escherichia coli IAI1 7124410 YP_002386276.1 CDS ybhK NC_011741.1 864631 865539 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16272399; Product type pe : putative enzyme; putative transferase complement(864631..865539) Escherichia coli IAI1 7125556 YP_002386277.1 CDS moaA NC_011741.1 865936 866925 D together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 865936..866925 Escherichia coli IAI1 7124841 YP_002386278.1 CDS moaB NC_011741.1 866947 867459 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93368423; Product type pf : putative factor; molybdopterin biosynthesis protein B 866947..867459 Escherichia coli IAI1 7124290 YP_002386279.1 CDS moaC NC_011741.1 867462 867947 D MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 867462..867947 Escherichia coli IAI1 7124291 YP_002386280.1 CDS moaD NC_011741.1 867940 868185 D catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 867940..868185 Escherichia coli IAI1 7124292 YP_002386281.1 CDS moaE NC_011741.1 868187 868639 D catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin guanine dinucleotide biosynthesis protein MoaE 868187..868639 Escherichia coli IAI1 7124293 YP_002386282.1 CDS ybhL NC_011741.1 868776 869480 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 868776..869480 Escherichia coli IAI1 7124294 YP_002386283.1 CDS ECIAI1_0822 NC_011741.1 869625 870329 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 869625..870329 Escherichia coli IAI1 7124842 YP_002386284.1 CDS ybhM NC_011741.1 870399 871112 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 870399..871112 Escherichia coli IAI1 7128627 YP_002386285.1 CDS ybhN NC_011741.1 871148 872104 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(871148..872104) Escherichia coli IAI1 7124843 YP_002386286.1 CDS ybhO NC_011741.1 872104 873345 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20102623, 10634942; Product type e : enzyme; cardiolipin synthase 2 complement(872104..873345) Escherichia coli IAI1 7124844 YP_002386287.1 CDS ybhP NC_011741.1 873342 874103 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal-dependent hydrolase complement(873342..874103) Escherichia coli IAI1 7124845 YP_002386288.1 CDS ybhQ NC_011741.1 874236 874646 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 874236..874646 Escherichia coli IAI1 7124846 YP_002386289.1 CDS ybhR NC_011741.1 874608 875714 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease complement(874608..875714) Escherichia coli IAI1 7124847 YP_002386290.1 CDS ybhS NC_011741.1 875725 876858 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease complement(875725..876858) Escherichia coli IAI1 7124848 YP_002386291.1 CDS ybhF NC_011741.1 876851 878587 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein complement(876851..878587) Escherichia coli IAI1 7124849 YP_002386292.1 CDS ybhG NC_011741.1 878580 879578 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16092522; Product type pt : putative transporter; hypothetical protein complement(878580..879578) Escherichia coli IAI1 7124836 YP_002386293.1 CDS ybiH NC_011741.1 879578 880249 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(879578..880249) Escherichia coli IAI1 7124837 YP_002386294.1 CDS rhlE NC_011741.1 880478 881842 D this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 880478..881842 Escherichia coli IAI1 7124854 YP_002386295.1 CDS ECIAI1_0834 NC_011741.1 881849 882049 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 881849..882049 Escherichia coli IAI1 7124980 YP_002386296.1 CDS ECIAI1_0835 NC_011741.1 882113 883093 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 882113..883093 Escherichia coli IAI1 7128628 YP_002386297.1 CDS ybiA NC_011741.1 883353 883835 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(883353..883835) Escherichia coli IAI1 7128629 YP_002386298.1 CDS dinG NC_011741.1 883955 886105 D helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 883955..886105 Escherichia coli IAI1 7124851 YP_002386299.1 CDS ybiB NC_011741.1 886133 887095 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; glycosyl transferase family protein 886133..887095 Escherichia coli IAI1 7124589 YP_002386300.1 CDS ybiC NC_011741.1 887236 888318 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8405966; Product type pe : putative enzyme; hypothetical protein 887236..888318 Escherichia coli IAI1 7124852 YP_002386301.1 CDS ybiJ NC_011741.1 888547 888807 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(888547..888807) Escherichia coli IAI1 7124853 YP_002386302.1 CDS ybiI NC_011741.1 889072 889338 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(889072..889338) Escherichia coli IAI1 7124856 YP_002386303.1 CDS ybiX NC_011741.1 889412 890089 R Evidence 4 : Homologs of previously reported genes of unknown function; putative hydroxylase complement(889412..890089) Escherichia coli IAI1 7124855 YP_002386304.1 CDS fiu NC_011741.1 890131 892413 R Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein; catecholate siderophore receptor Fiu complement(890131..892413) Escherichia coli IAI1 7124705 YP_002386305.1 CDS ybiM NC_011741.1 892678 893082 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(892678..893082) Escherichia coli IAI1 7127121 YP_002386306.1 CDS ybiN NC_011741.1 893214 894140 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative SAM-dependent methyltransferase 893214..894140 Escherichia coli IAI1 7124857 YP_002386307.1 CDS ybiO NC_011741.1 894137 896362 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein complement(894137..896362) Escherichia coli IAI1 7124858 YP_002386308.1 CDS glnQ NC_011741.1 896479 897201 R similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein complement(896479..897201) Escherichia coli IAI1 7124859 YP_002386309.1 CDS glnP NC_011741.1 897198 897857 R similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease complement(897198..897857) Escherichia coli IAI1 7128330 YP_002386310.1 CDS glnH NC_011741.1 897996 898742 R similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein complement(897996..898742) Escherichia coli IAI1 7128329 YP_002386311.1 CDS dps NC_011741.1 899146 899649 R binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps complement(899146..899649) Escherichia coli IAI1 7128326 YP_002386312.1 CDS rhtA NC_011741.1 899948 900835 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12648727, 8021175; Product type t : transporter; threonine and homoserine efflux system complement(899948..900835) Escherichia coli IAI1 7124621 YP_002386313.1 CDS ompX NC_011741.1 901187 901702 D OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 901187..901702 Escherichia coli IAI1 7124989 YP_002386314.1 CDS ybiP NC_011741.1 901751 903334 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16514146; Product type pe : putative enzyme; hypothetical protein complement(901751..903334) Escherichia coli IAI1 7125986 YP_002386315.1 CDS mntR NC_011741.1 903920 904387 D Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 903920..904387 Escherichia coli IAI1 7124647 YP_002386316.1 CDS ybiR NC_011741.1 904384 905502 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 904384..905502 Escherichia coli IAI1 7124289 YP_002386317.1 CDS ybiS NC_011741.1 905561 906481 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10493123, 9298646; hypothetical protein complement(905561..906481) Escherichia coli IAI1 7124861 YP_002386318.1 CDS ybiT NC_011741.1 906700 908292 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11916677; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 906700..908292 Escherichia coli IAI1 7124862 YP_002386319.1 CDS ECIAI1_0859 NC_011741.1 908571 909551 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 908571..909551 Escherichia coli IAI1 7124701 YP_002386320.1 CDS ybiU NC_011741.1 909807 911072 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(909807..911072) Escherichia coli IAI1 7128630 YP_002386321.1 CDS ybiV NC_011741.1 911224 912039 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15657928; Product type e : enzyme; type II HAD phosphatase complement(911224..912039) Escherichia coli IAI1 7124702 YP_002386322.1 CDS ybiW NC_011741.1 912185 914617 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16218870; Product type pe : putative enzyme; putative glycyl radical cofactor protein complement(912185..914617) Escherichia coli IAI1 7124703 YP_002386323.1 CDS ybiY NC_011741.1 914623 915549 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15581584; Product type pe : putative enzyme; putative AdoMet-dependent glycyl radical activating enzyme complement(914623..915549) Escherichia coli IAI1 7124704 YP_002386324.1 CDS fsaA NC_011741.1 915653 916315 D similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 915653..916315 Escherichia coli IAI1 7124706 YP_002386325.1 CDS moeB NC_011741.1 916494 917243 R ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB complement(916494..917243) Escherichia coli IAI1 7128228 YP_002386326.1 CDS moeA NC_011741.1 917243 918478 R is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA complement(917243..918478) Escherichia coli IAI1 7124303 YP_002386327.1 CDS iaaA NC_011741.1 918682 919647 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15159592, 20508248, 3045084, 7984428; Product type e : enzyme; L-asparaginase 918682..919647 Escherichia coli IAI1 7124302 YP_002386328.1 CDS yliA NC_011741.1 919667 921505 D with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 919667..921505 Escherichia coli IAI1 7126036 YP_002386329.1 CDS yliB NC_011741.1 921525 923063 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17366475; Product type pt : putative transporter; putative peptide ABC transporter periplasmic-binding protein 921525..923063 Escherichia coli IAI1 7126661 YP_002386330.1 CDS yliC NC_011741.1 923081 924001 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative peptide ABC transporter permease 923081..924001 Escherichia coli IAI1 7126662 YP_002386331.1 CDS yliD NC_011741.1 924004 924915 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative peptide ABC transporter permease 924004..924915 Escherichia coli IAI1 7126663 YP_002386332.1 CDS yliE NC_011741.1 925093 927441 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 925093..927441 Escherichia coli IAI1 7126664 YP_002386333.1 CDS yliF NC_011741.1 927449 928777 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type pe : putative enzyme; putative diguanylate cyclase 927449..928777 Escherichia coli IAI1 7126665 YP_002386334.1 CDS rimO NC_011741.1 928824 930149 R catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase complement(928824..930149) Escherichia coli IAI1 7126666 YP_002386335.1 CDS bssR NC_011741.1 930362 930745 D BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 930362..930745 Escherichia coli IAI1 7126667 YP_002386336.1 CDS yliI NC_011741.1 930856 931971 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16522795, 16864586; Product type e : enzyme; PQQ-dependent aldose sugar dehydrogenase 930856..931971 Escherichia coli IAI1 7124421 YP_002386337.1 CDS yliJ NC_011741.1 931968 932594 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase complement(931968..932594) Escherichia coli IAI1 7126668 YP_002386338.1 CDS dacC NC_011741.1 932840 934042 D penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase fraction C 932840..934042 Escherichia coli IAI1 7126669 YP_002386339.1 CDS deoR NC_011741.1 934089 934847 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89231635, 89336786, 92231401, 2994018; Product type r : regulator; DNA-binding transcriptional repressor DeoR complement(934089..934847) Escherichia coli IAI1 7126910 YP_002386340.1 CDS ybjG NC_011741.1 934905 935501 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15778224; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase complement(934905..935501) Escherichia coli IAI1 7124567 YP_002386341.1 CDS cmr NC_011741.1 935786 937018 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10022825, 12578981, 14688269, 21217867, 21450803, 9079913, 9644262, 99030337, 8655497; Product type t : transporter; multidrug efflux system protein 935786..937018 Escherichia coli IAI1 7124710 YP_002386342.1 CDS ybjH NC_011741.1 937059 937343 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(937059..937343) Escherichia coli IAI1 7126339 YP_002386343.1 CDS ybjI NC_011741.1 937429 938244 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme; putative phosphatase complement(937429..938244) Escherichia coli IAI1 7124711 YP_002386344.1 CDS ybjJ NC_011741.1 938244 939452 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(938244..939452) Escherichia coli IAI1 7124712 YP_002386345.1 CDS ybjK NC_011741.1 939536 940072 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 939536..940072 Escherichia coli IAI1 7124713 YP_002386346.1 CDS ybjL NC_011741.1 940247 941932 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein complement(940247..941932) Escherichia coli IAI1 7124648 YP_002386347.1 CDS ybjM NC_011741.1 942202 942579 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 942202..942579 Escherichia coli IAI1 7124715 YP_002386348.1 CDS grxA NC_011741.1 942609 942866 R functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 1 complement(942609..942866) Escherichia coli IAI1 7124716 YP_002386349.1 CDS ybjC NC_011741.1 943026 943313 D YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 943026..943313 Escherichia coli IAI1 7128468 YP_002386350.1 CDS nfsA NC_011741.1 943297 944019 D NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 943297..944019 Escherichia coli IAI1 7124707 YP_002386351.1 CDS rimK NC_011741.1 944080 944982 D responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 944080..944982 Escherichia coli IAI1 7127872 YP_002386352.1 CDS ybjN NC_011741.1 945070 945546 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 945070..945546 Escherichia coli IAI1 7125003 YP_002386353.1 CDS potF NC_011741.1 945897 947009 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992, 9651355, 9298646, 8416922; Product type t : transporter; putrescine ABC transporter periplasmic-binding protein 945897..947009 Escherichia coli IAI1 7124717 YP_002386354.1 CDS potG NC_011741.1 947104 948237 D part of the PotFGHI ATP-dependent putrescine transporter; putrescine transporter ATP-binding subunit 947104..948237 Escherichia coli IAI1 7126118 YP_002386355.1 CDS potH NC_011741.1 948247 949200 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992; Product type t : transporter; putrescine ABC transporter membrane protein 948247..949200 Escherichia coli IAI1 7126119 YP_002386356.1 CDS potI NC_011741.1 949197 950042 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992; Product type t : transporter; putrescine ABC transporter membrane protein 949197..950042 Escherichia coli IAI1 7126120 YP_002386357.1 CDS ybjO NC_011741.1 950102 950590 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 950102..950590 Escherichia coli IAI1 7126121 YP_002386358.1 CDS rumB NC_011741.1 950631 951758 D RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 950631..951758 Escherichia coli IAI1 7124718 YP_002386359.1 CDS artJ NC_011741.1 951933 952664 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93273744, 9298646, 9600841, 8801422; Product type t : transporter; arginine ABC transporter periplasmic-binding protein complement(951933..952664) Escherichia coli IAI1 7124634 YP_002386360.1 CDS artM NC_011741.1 952956 953624 R with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM complement(952956..953624) Escherichia coli IAI1 7125821 YP_002386361.1 CDS artQ NC_011741.1 953624 954340 R with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ complement(953624..954340) Escherichia coli IAI1 7125822 YP_002386362.1 CDS artI NC_011741.1 954347 955078 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93273744, 9298646, 9600841, 8801422, 9740056; Product type t : transporter; arginine ABC transporter periplasmic-binding protein complement(954347..955078) Escherichia coli IAI1 7125824 YP_002386363.1 CDS artP NC_011741.1 955096 955824 R With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit complement(955096..955824) Escherichia coli IAI1 7125820 YP_002386364.1 CDS ybjP NC_011741.1 956042 956557 R induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS; hypothetical protein complement(956042..956557) Escherichia coli IAI1 7125823 YP_002386365.1 CDS ybjQ NC_011741.1 956683 957006 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 956683..957006 Escherichia coli IAI1 7124719 YP_002386366.1 CDS ybjR NC_011741.1 957003 957833 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cell wall amidase and lipoprotein 957003..957833 Escherichia coli IAI1 7124720 YP_002386367.1 CDS ybjS NC_011741.1 957830 958843 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P)H-binding oxidoreductase complement(957830..958843) Escherichia coli IAI1 7124721 YP_002386368.1 CDS ybjT NC_011741.1 958942 960372 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(958942..960372) Escherichia coli IAI1 7124722 YP_002386369.1 CDS ltaE NC_011741.1 960383 961384 R low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase complement(960383..961384) Escherichia coli IAI1 7124723 YP_002386370.1 CDS poxB NC_011741.1 961421 963139 R catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase complement(961421..963139) Escherichia coli IAI1 7127640 YP_002386371.1 CDS hcr NC_011741.1 963272 964240 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20117674; Product type e : enzyme; HCP oxidoreductase, NADH-dependent complement(963272..964240) Escherichia coli IAI1 7126123 YP_002386372.1 CDS hcp NC_011741.1 964252 965904 R catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase complement(964252..965904) Escherichia coli IAI1 7128497 YP_002386373.1 CDS ybjE NC_011741.1 966048 966947 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(966048..966947) Escherichia coli IAI1 7128496 YP_002386374.1 CDS aqpZ NC_011741.1 967404 968099 R porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z complement(967404..968099) Escherichia coli IAI1 7124709 YP_002386375.1 CDS ybjD NC_011741.1 968525 970183 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 968525..970183 Escherichia coli IAI1 7125774 YP_002386376.1 CDS ybjX NC_011741.1 970180 971172 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(970180..971172) Escherichia coli IAI1 7124708 YP_002386377.1 CDS macA NC_011741.1 971287 972402 D confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 971287..972402 Escherichia coli IAI1 7124724 YP_002386378.1 CDS macB NC_011741.1 972399 974345 D with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease 972399..974345 Escherichia coli IAI1 7127650 YP_002386379.1 CDS cspD NC_011741.1 974418 974642 R inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD complement(974418..974642) Escherichia coli IAI1 7127651 YP_002386380.1 CDS clpS NC_011741.1 974965 975285 D involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 974965..975285 Escherichia coli IAI1 7125934 YP_002386381.1 CDS clpA NC_011741.1 975316 977592 D ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit 975316..977592 Escherichia coli IAI1 7126335 YP_002386382.1 CDS ECIAI1_0923 NC_011741.1 977649 977969 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(977649..977969) Escherichia coli IAI1 7126332 YP_002386383.1 CDS infA NC_011741.1 978336 978554 R stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 complement(978336..978554) Escherichia coli IAI1 7128059 YP_002386384.1 CDS aat NC_011741.1 978839 979543 R leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase complement(978839..979543) Escherichia coli IAI1 7126064 YP_002386385.1 CDS cydC NC_011741.1 979585 981306 R in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component complement(979585..981306) Escherichia coli IAI1 7125684 YP_002386386.1 CDS cydD NC_011741.1 981307 983073 R in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding component complement(981307..983073) Escherichia coli IAI1 7126876 YP_002386387.1 CDS trxB NC_011741.1 983196 984161 R catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase complement(983196..984161) Escherichia coli IAI1 7126877 YP_002386388.1 CDS lrp NC_011741.1 984706 985200 D mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 984706..985200 Escherichia coli IAI1 7127507 YP_002386389.1 CDS ftsK NC_011741.1 985335 989480 D DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 985335..989480 Escherichia coli IAI1 7127631 YP_002386390.1 CDS lolA NC_011741.1 989632 990246 D participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 989632..990246 Escherichia coli IAI1 7128237 YP_002386391.1 CDS ycaJ NC_011741.1 990257 991600 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7567469, 7628437, 11459952, 11029431; Product type cp : cell process; recombination factor protein RarA 990257..991600 Escherichia coli IAI1 7126433 YP_002386392.1 CDS serS NC_011741.1 991691 992983 D catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 991691..992983 Escherichia coli IAI1 7124728 YP_002386393.1 CDS dmsA NC_011741.1 993222 995666 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91008971, 92011349, 94171715, 10801884, 3062312; Product type e : enzyme; dimethyl sulfoxide reductase, anaerobic subunit A 993222..995666 Escherichia coli IAI1 7127911 YP_002386394.1 CDS dmsB NC_011741.1 995677 996294 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91070067, 91355180, 92011349, 3062312; Product type e : enzyme; dimethyl sulfoxide reductase, anaerobic subunit B 995677..996294 Escherichia coli IAI1 7124600 YP_002386395.1 CDS dmsC NC_011741.1 996296 997159 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91008971, 92011349, 3062312, 8429002; Product type e : enzyme; dimethyl sulfoxide reductase, anaerobic subunit C 996296..997159 Escherichia coli IAI1 7124601 YP_002386396.1 CDS ycaC NC_011741.1 997195 997821 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9782055, 3062312, 11714269; Product type pe : putative enzyme; putative hydrolase complement(997195..997821) Escherichia coli IAI1 7124602 YP_002386397.1 CDS ycaD NC_011741.1 998136 999284 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS family transporter protein 998136..999284 Escherichia coli IAI1 7124725 YP_002386398.1 CDS ycaM NC_011741.1 999494 1000924 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type pt : putative transporter; putative transporter 999494..1000924 Escherichia coli IAI1 7124726 YP_002386399.1 CDS ycaN NC_011741.1 1000925 1001833 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1000925..1001833) Escherichia coli IAI1 7124731 YP_002386400.1 CDS ycaK NC_011741.1 1001933 1002523 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3053170; Product type pe : putative enzyme; hypothetical protein 1001933..1002523 Escherichia coli IAI1 7124732 YP_002386401.1 CDS pflA NC_011741.1 1002605 1003345 R activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 complement(1002605..1003345) Escherichia coli IAI1 7124729 YP_002386402.1 CDS pflB NC_011741.1 1003537 1005819 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91064082, 92276323, 10504733, 1310545, 2651404, 3053170, 9629924; Product type e : enzyme; pyruvate formate lyase I complement(1003537..1005819) Escherichia coli IAI1 7124180 YP_002386403.1 CDS focA NC_011741.1 1005874 1006731 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293770, 2651404; Product type t : transporter; formate transporter complement(1005874..1006731) Escherichia coli IAI1 7124181 YP_002386404.1 CDS ycaO NC_011741.1 1007137 1008897 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1007137..1008897) Escherichia coli IAI1 7127256 YP_002386405.1 CDS ycaP NC_011741.1 1009027 1009719 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1009027..1009719 Escherichia coli IAI1 7124733 YP_002386406.1 CDS serC NC_011741.1 1009918 1011006 D catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 1009918..1011006 Escherichia coli IAI1 7124734 YP_002386407.1 CDS aroA NC_011741.1 1011077 1012360 D catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1011077..1012360 Escherichia coli IAI1 7127910 YP_002386408.1 CDS ycaL NC_011741.1 1012529 1013293 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative lipoprotein with metallohydrolase domain 1012529..1013293 Escherichia coli IAI1 7125802 YP_002386409.1 CDS ECIAI1_0950 NC_011741.1 1013243 1013389 R hypothetical protein complement(1013243..1013389) Escherichia coli IAI1 7124730 YP_002386410.1 CDS cmk NC_011741.1 1013466 1014149 D Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1013466..1014149 Escherichia coli IAI1 7128632 YP_002386411.1 CDS rpsA NC_011741.1 1014260 1015933 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1014260..1015933 Escherichia coli IAI1 7126338 YP_002386412.1 CDS ihfB NC_011741.1 1016093 1016377 D This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 1016093..1016377 Escherichia coli IAI1 7128407 YP_002386413.1 CDS ycaI NC_011741.1 1016584 1018848 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1016584..1018848 Escherichia coli IAI1 7126048 YP_002386414.1 CDS msbA NC_011741.1 1018885 1020633 D involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease 1018885..1020633 Escherichia coli IAI1 7124727 YP_002386415.1 CDS lpxK NC_011741.1 1020630 1021616 D transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 1020630..1021616 Escherichia coli IAI1 7124478 YP_002386416.1 CDS ycaQ NC_011741.1 1021653 1022885 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1021653..1022885 Escherichia coli IAI1 7127627 YP_002386417.1 CDS ycaR NC_011741.1 1022937 1023119 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1022937..1023119 Escherichia coli IAI1 7124735 YP_002386418.1 CDS kdsB NC_011741.1 1023116 1023862 D CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 1023116..1023862 Escherichia coli IAI1 7124736 YP_002386419.1 CDS ycbJ NC_011741.1 1024016 1024909 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1024016..1024909 Escherichia coli IAI1 7126379 YP_002386420.1 CDS ycbC NC_011741.1 1024886 1025665 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1024886..1025665) Escherichia coli IAI1 7124741 YP_002386421.1 CDS smtA NC_011741.1 1025801 1026586 D involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; putative metallothionein SmtA 1025801..1026586 Escherichia coli IAI1 7124738 YP_002386422.1 CDS mukF NC_011741.1 1026583 1027905 D acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 1026583..1027905 Escherichia coli IAI1 7127940 YP_002386423.1 CDS mukE NC_011741.1 1027913 1028590 D acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 1027913..1028590 Escherichia coli IAI1 7124491 YP_002386424.1 CDS mukB NC_011741.1 1028590 1033050 D SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 1028590..1033050 Escherichia coli IAI1 7124490 YP_002386425.1 CDS ycbB NC_011741.1 1033311 1035158 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 1033311..1035158 Escherichia coli IAI1 7124489 YP_002386426.1 CDS ycbK NC_011741.1 1035339 1035887 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1035339..1035887 Escherichia coli IAI1 7124737 YP_002386427.1 CDS ycbL NC_011741.1 1035914 1036561 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14529289; Product type pe : putative enzyme; putative metal-binding hydrolase 1035914..1036561 Escherichia coli IAI1 7124742 YP_002386428.1 CDS aspC NC_011741.1 1036783 1037973 R catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase complement(1036783..1037973) Escherichia coli IAI1 7124743 YP_002386429.1 CDS ompF NC_011741.1 1038158 1039246 R outer membrane porin F; 1a; Ia; b; outer membrane protein F complement(1038158..1039246) Escherichia coli IAI1 7126266 YP_002386430.1 CDS asnC NC_011741.1 1039848 1041248 R catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase complement(1039848..1041248) Escherichia coli IAI1 7125980 YP_002386431.1 CDS pncB NC_011741.1 1041417 1042619 R catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(1041417..1042619) Escherichia coli IAI1 7126264 YP_002386432.1 CDS pepN NC_011741.1 1042885 1045497 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101837, 86164315, 87163509, 2436977, 3018440; Product type e : enzyme; aminopeptidase N 1042885..1045497 Escherichia coli IAI1 7126106 YP_002386433.1 CDS ssuB NC_011741.1 1045704 1046471 R part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease; aliphatic sulfonates transport ATP-binding subunit complement(1045704..1046471) Escherichia coli IAI1 7124173 YP_002386434.1 CDS ssuC NC_011741.1 1046468 1047259 R part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter permease subunit complement(1046468..1047259) Escherichia coli IAI1 7126182 YP_002386435.1 CDS ssuD NC_011741.1 1047270 1048415 R catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase complement(1047270..1048415) Escherichia coli IAI1 7126183 YP_002386436.1 CDS ssuA NC_011741.1 1048412 1049371 R part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit complement(1048412..1049371) Escherichia coli IAI1 7126184 YP_002386437.1 CDS ssuE NC_011741.1 1049364 1049939 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20245523, 99410391, 99436146, 8774726; Product type e : enzyme; NAD(P)H-dependent FMN reductase complement(1049364..1049939) Escherichia coli IAI1 7126181 YP_002386438.1 CDS ycbQ NC_011741.1 1050286 1050837 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type ps : putative structure; putative fimbrial-like adhesin protein 1050286..1050837 Escherichia coli IAI1 7126185 YP_002386439.1 CDS ycbR NC_011741.1 1050920 1051621 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative periplasmic pilin chaperone 1050920..1051621 Escherichia coli IAI1 7124744 YP_002386440.1 CDS ycbS NC_011741.1 1051646 1054246 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative outer membrane export usher protein 1051646..1054246 Escherichia coli IAI1 7124745 YP_002386441.1 CDS ycbT NC_011741.1 1054237 1055307 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7721701; Product type ps : putative structure; putative fimbrial-like adhesin protein 1054237..1055307 Escherichia coli IAI1 7124746 YP_002386442.1 CDS ycbU NC_011741.1 1055319 1055861 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein 1055319..1055861 Escherichia coli IAI1 7124747 YP_002386443.1 CDS ycbV NC_011741.1 1055869 1056384 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative exported fimbrial-like adhesin protein 1055869..1056384 Escherichia coli IAI1 7124748 YP_002386444.1 CDS ycbF NC_011741.1 1056377 1057087 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putativi pili assembly chaperone 1056377..1057087 Escherichia coli IAI1 7124749 YP_002386445.1 CDS pyrD NC_011741.1 1057198 1058208 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1057198..1058208 Escherichia coli IAI1 7124739 YP_002386446.1 CDS ycbW NC_011741.1 1058382 1058924 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1058382..1058924 Escherichia coli IAI1 7126571 YP_002386447.1 CDS ycbX NC_011741.1 1058921 1060030 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1327782; Product type pe : putative enzyme; putative 2Fe-2S cluster-containing protein complement(1058921..1060030) Escherichia coli IAI1 7124750 YP_002386448.1 CDS rlmL NC_011741.1 1060274 1062382 D catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 1060274..1062382 Escherichia coli IAI1 7124751 YP_002386449.1 CDS uup NC_011741.1 1062394 1064301 D Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 1062394..1064301 Escherichia coli IAI1 7124752 YP_002386450.1 CDS pqiA NC_011741.1 1064431 1065684 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95270582; Product type cp : cell process; paraquat-inducible membrane protein A 1064431..1065684 Escherichia coli IAI1 7125554 YP_002386451.1 CDS pqiB NC_011741.1 1065689 1067329 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95270582; Product type cp : cell process; paraquat-inducible protein B 1065689..1067329 Escherichia coli IAI1 7126140 YP_002386452.1 CDS ymbA NC_011741.1 1067341 1067889 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1067341..1067889 Escherichia coli IAI1 7126141 YP_002386453.1 CDS rmf NC_011741.1 1068145 1068312 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1101029, 90207255, 2832401, 8440252; Product type f : factor; ribosome modulation factor 1068145..1068312 Escherichia coli IAI1 7126671 YP_002386454.1 CDS fabA NC_011741.1 1068382 1068900 R catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-(acyl carrier protein) dehydratase complement(1068382..1068900) Escherichia coli IAI1 7125013 YP_002386455.1 CDS ycbZ NC_011741.1 1068969 1070729 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-dependent protease complement(1068969..1070729) Escherichia coli IAI1 7127052 YP_002386456.1 CDS ycbG NC_011741.1 1070915 1071367 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1070915..1071367 Escherichia coli IAI1 7124753 YP_002386457.1 CDS ompA NC_011741.1 1071442 1072566 R OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein A complement(1071442..1072566) Escherichia coli IAI1 7124740 YP_002386458.1 CDS sulA NC_011741.1 1072851 1073360 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10368140, 91072263, 93163041, 98348458, 3297925, 6253901, 6306396; Product type cp : cell process; SOS cell division inhibitor complement(1072851..1073360) Escherichia coli IAI1 7126078 YP_002386459.1 CDS yccR NC_011741.1 1073579 1074208 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1073579..1074208 Escherichia coli IAI1 7126201 YP_002386460.1 CDS yccS NC_011741.1 1074171 1076324 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1074171..1076324) Escherichia coli IAI1 7124761 YP_002386461.1 CDS yccF NC_011741.1 1076343 1076789 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1076343..1076789) Escherichia coli IAI1 7124762 YP_002386462.1 CDS helD NC_011741.1 1076912 1078966 D catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 1076912..1078966 Escherichia coli IAI1 7124758 YP_002386463.1 CDS mgsA NC_011741.1 1078998 1079456 R catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase complement(1078998..1079456) Escherichia coli IAI1 7128504 YP_002386464.1 CDS yccT NC_011741.1 1079552 1080214 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1079552..1080214) Escherichia coli IAI1 7124260 YP_002386465.1 CDS yccU NC_011741.1 1080387 1080800 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative CoA-binding protein 1080387..1080800 Escherichia coli IAI1 7124763 YP_002386466.1 CDS yccV NC_011741.1 1080845 1081162 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12700277, 15569148; Product type f : factor; heat shock protein HspQ complement(1080845..1081162) Escherichia coli IAI1 7124764 YP_002386467.1 CDS yccW NC_011741.1 1081220 1082323 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative AdoMet-dependent methyltransferase, UPF0064 family complement(1081220..1082323) Escherichia coli IAI1 7124765 YP_002386468.1 CDS yccX NC_011741.1 1082292 1082783 D catalyzes the hydrolysis of acylphosphate; acylphosphatase 1082292..1082783 Escherichia coli IAI1 7124766 YP_002386469.1 CDS tusE NC_011741.1 1082780 1083109 R transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE complement(1082780..1083109) Escherichia coli IAI1 7124767 YP_002386470.1 CDS yccA NC_011741.1 1083200 1083859 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6376117; Product type m : membrane component; hypothetical protein complement(1083200..1083859) Escherichia coli IAI1 7127523 YP_002386471.1 CDS ECIAI1_1012 NC_011741.1 1084061 1084237 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1084061..1084237) Escherichia coli IAI1 7124754 YP_002386472.1 CDS hyaA NC_011741.1 1084580 1085698 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86192450, 90202716, 92215587; Product type e : enzyme; hydrogenase 1 small subunit 1084580..1085698 Escherichia coli IAI1 7128058 YP_002386473.1 CDS hyaB NC_011741.1 1085695 1087488 D involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit 1085695..1087488 Escherichia coli IAI1 7125326 YP_002386474.1 CDS hyaC NC_011741.1 1087507 1088214 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202716, 91310595, 92215587; Product type c : carrier; hydrogenase 1 b-type cytochrome subunit 1087507..1088214 Escherichia coli IAI1 7125327 YP_002386475.1 CDS hyaD NC_011741.1 1088211 1088798 D HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 1088211..1088798 Escherichia coli IAI1 7125328 YP_002386476.1 CDS hyaE NC_011741.1 1088795 1089193 D involved in processing hydrogenase proteins HyaA and HyaB; hydrogenase-1 operon protein HyaE 1088795..1089193 Escherichia coli IAI1 7125329 YP_002386477.1 CDS hyaF NC_011741.1 1089190 1090047 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202716, 91310595, 92215587; Product type f : factor; hydrogenase-1 nickel incorporation protein 1089190..1090047 Escherichia coli IAI1 7125330 YP_002386478.1 CDS appC NC_011741.1 1090181 1091725 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92049231, 96198179; Product type c : carrier; cytochrome bd-II oxidase subunit I 1090181..1091725 Escherichia coli IAI1 7125331 YP_002386479.1 CDS appB NC_011741.1 1091737 1092873 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92049231, 96198179; Product type c : carrier; cytochrome bd-II oxidase subunit II 1091737..1092873 Escherichia coli IAI1 7125772 YP_002386480.1 CDS appA NC_011741.1 1093058 1094356 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20122624, 92049231, 93054596, 10696472, 2168385, 3038201, 8387749; Product type e : enzyme; phosphoanhydride phosphorylase 1093058..1094356 Escherichia coli IAI1 7125771 YP_002386481.1 CDS yccC NC_011741.1 1094471 1096651 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10369665, 11090276, 2168385, 7984428; Product type e : enzyme; cryptic autophosphorylating protein tyrosine kinase Etk complement(1094471..1096651) Escherichia coli IAI1 7125770 YP_002386482.1 CDS etp NC_011741.1 1096671 1097117 R Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk; phosphotyrosine-protein phosphatase complement(1096671..1097117) Escherichia coli IAI1 7124755 YP_002386483.1 CDS yccZ NC_011741.1 1097105 1098244 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8759852; Product type pt : putative transporter; putative exopolysaccharide export protein complement(1097105..1098244) Escherichia coli IAI1 7125092 YP_002386484.1 CDS ymcA NC_011741.1 1098290 1100386 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1098290..1100386) Escherichia coli IAI1 7124768 YP_002386485.1 CDS ymcB NC_011741.1 1100386 1101132 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1100386..1101132) Escherichia coli IAI1 7126672 YP_002386486.1 CDS ymcC NC_011741.1 1101129 1101773 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein complement(1101129..1101773) Escherichia coli IAI1 7126673 YP_002386487.1 CDS ymcD NC_011741.1 1101880 1102185 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1101880..1102185) Escherichia coli IAI1 7126674 YP_002386488.1 CDS cspH NC_011741.1 1102627 1102839 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9484881, 9439003; Product type f : factor; stress protein, member of the CspA-family complement(1102627..1102839) Escherichia coli IAI1 7126675 YP_002386489.1 CDS ECIAI1_1030 NC_011741.1 1102741 1102884 D Evidence 6 : Doubtful CDS; hypothetical protein 1102741..1102884 Escherichia coli IAI1 7126850 YP_002386490.1 CDS cspG NC_011741.1 1103125 1103337 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9484881, 15466053, 8631696, 9439003; Product type r : regulator; cold shock protein CspG 1103125..1103337 Escherichia coli IAI1 7128634 YP_002386491.1 CDS ECIAI1_1032 NC_011741.1 1103276 1103536 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative cold-shock protein (fragment) 1103276..1103536 Escherichia coli IAI1 7128610 YP_002386492.1 CDS gnsA NC_011741.1 1103731 1103904 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15317805, 11544213; Product type pr : putative regulator; putative regulator of phosphatidylethanolamine synthesis 1103731..1103904 Escherichia coli IAI1 7128635 YP_002386493.1 CDS yccM NC_011741.1 1103953 1105026 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S membrane protein complement(1103953..1105026) Escherichia coli IAI1 7128367 YP_002386494.1 CDS ECIAI1_1035 NC_011741.1 1104900 1105064 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1104900..1105064) Escherichia coli IAI1 7124760 YP_002386495.1 CDS torS NC_011741.1 1105098 1107842 R Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide; hybrid sensory histidine kinase TorS complement(1105098..1107842) Escherichia coli IAI1 7128636 YP_002386496.1 CDS torT NC_011741.1 1107925 1108953 D periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 1107925..1108953 Escherichia coli IAI1 7127470 YP_002386497.1 CDS torR NC_011741.1 1108926 1109618 R response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR complement(1108926..1109618) Escherichia coli IAI1 7127471 YP_002386498.1 CDS torC NC_011741.1 1109748 1110920 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293785, 94314186, 99340208, 11056172, 11562502; Product type c : carrier; trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit 1109748..1110920 Escherichia coli IAI1 7127469 YP_002386499.1 CDS torA NC_011741.1 1110920 1113466 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88193091, 90089471, 94293785, 8302830, 8022286; Product type e : enzyme; trimethylamine N-oxide (TMAO) reductase I, catalytic subunit 1110920..1113466 Escherichia coli IAI1 7127467 YP_002386500.1 CDS torD NC_011741.1 1113463 1114062 D TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; chaperone protein TorD 1113463..1114062 Escherichia coli IAI1 7127466 YP_002386501.1 CDS cbpM NC_011741.1 1114155 1114460 R with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM complement(1114155..1114460) Escherichia coli IAI1 7127468 YP_002386502.1 CDS cbpA NC_011741.1 1114460 1115380 R functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA complement(1114460..1115380) Escherichia coli IAI1 7124452 YP_002386503.1 CDS agp NC_011741.1 1117190 1118431 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12455612, 90368616, 91297199, 2153660, 9298646; Product type e : enzyme; glucose-1-phosphatase/inositol phosphatase 1117190..1118431 Escherichia coli IAI1 7124757 YP_002386504.1 CDS yccJ NC_011741.1 1118469 1118696 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1118469..1118696) Escherichia coli IAI1 7125735 YP_002386505.1 CDS wrbA NC_011741.1 1118717 1119313 R stationary phase protein that binds TrpR repressor; TrpR binding protein WrbA complement(1118717..1119313) Escherichia coli IAI1 7124759 YP_002386506.1 CDS ECIAI1_1049 NC_011741.1 1119523 1119753 D Evidence 6 : Doubtful CDS; hypothetical protein 1119523..1119753 Escherichia coli IAI1 7126457 YP_002386507.1 CDS ymdF NC_011741.1 1119686 1119859 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1119686..1119859 Escherichia coli IAI1 7128637 YP_002386508.1 CDS rutG NC_011741.1 1120117 1121445 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type t : transporter; pyrimidine transporter complement(1120117..1121445) Escherichia coli IAI1 7126679 YP_002386509.1 CDS rutF NC_011741.1 1121466 1121960 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542, 10633095; Product type e : enzyme; flavin:NADH oxidoreductase subunit of alternative pyrimidine degradation pathway complement(1121466..1121960) Escherichia coli IAI1 7124642 YP_002386510.1 CDS rutE NC_011741.1 1121971 1122561 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; hypothetical protein complement(1121971..1122561) Escherichia coli IAI1 7124641 YP_002386511.1 CDS rutD NC_011741.1 1122571 1123371 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; enzyme of the alternative pyrimidine degradation pathway complement(1122571..1123371) Escherichia coli IAI1 7124640 YP_002386512.1 CDS rutC NC_011741.1 1123379 1123765 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; enzyme of the alternative pyrimidine degradation pathway complement(1123379..1123765) Escherichia coli IAI1 7124639 YP_002386513.1 CDS rutB NC_011741.1 1123777 1124469 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; enzyme of the alternative pyrimidine degradation pathway complement(1123777..1124469) Escherichia coli IAI1 7124638 YP_002386514.1 CDS rutA NC_011741.1 1124469 1125617 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; monooxygenase of the alternative pyrimidine degradation pathway complement(1124469..1125617) Escherichia coli IAI1 7124637 YP_002386515.1 CDS rutR NC_011741.1 1125848 1126486 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type r : regulator; DNA-binding transcriptional regulator of the alternative pyrimidine degradation pathway 1125848..1126486 Escherichia coli IAI1 7124636 YP_002386516.1 CDS putA NC_011741.1 1126526 1130488 R proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein; trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase complement(1126526..1130488) Escherichia coli IAI1 7124643 YP_002386517.1 CDS ECIAI1_1060 NC_011741.1 1130640 1130831 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1130640..1130831) Escherichia coli IAI1 7126558 YP_002386518.1 CDS putP NC_011741.1 1130911 1132419 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12923181, 88213396, 91227628, 93132799, 98359785, 1400239, 1567896, 3053649, 3053687, 3302614, 3325781, 8119910; Product type t : transporter; proline:sodium symporter 1130911..1132419 Escherichia coli IAI1 7128638 YP_002386519.1 CDS efeU NC_011741.1 1132952 1133791 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter; ferrous iron permease 1132952..1133791 Escherichia coli IAI1 7126559 YP_002386520.1 CDS efeO NC_011741.1 1133849 1134976 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17627767, 10493123; Product type t : transporter; hypothetical protein 1133849..1134976 Escherichia coli IAI1 7125052 YP_002386521.1 CDS efeB NC_011741.1 1134982 1136253 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17627767, 16551627, 15375152; Product type t : transporter; iron transport heme-binding periplasmic protein 1134982..1136253 Escherichia coli IAI1 7125051 YP_002386522.1 CDS phoH NC_011741.1 1136597 1137661 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8444794, 2160940; Product type pe : putative enzyme; hypothetical protein 1136597..1137661 Escherichia coli IAI1 7125050 YP_002386523.1 CDS ECIAI1_1066 NC_011741.1 1138245 1138931 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1138245..1138931 Escherichia coli IAI1 7124217 YP_002386524.1 CDS ycdW NC_011741.1 1139706 1140644 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11237876, 10493123; Product type e : enzyme; 2-ketoacid reductase 1139706..1140644 Escherichia coli IAI1 7128057 YP_002386525.1 CDS ycdX NC_011741.1 1140699 1141436 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12661000; Product type pe : putative enzyme; putative hydrolase 1140699..1141436 Escherichia coli IAI1 7124769 YP_002386526.1 CDS ycdY NC_011741.1 1141460 1142014 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1141460..1142014 Escherichia coli IAI1 7124770 YP_002386527.1 CDS ycdZ NC_011741.1 1142116 1142607 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1142116..1142607 Escherichia coli IAI1 7124771 YP_002386528.1 CDS csgG NC_011741.1 1142671 1143504 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8817489; Product type lp : lipoprotein; putative outer membrane lipoprotein involved in curli production assembly/transport complement(1142671..1143504) Escherichia coli IAI1 7124772 YP_002386529.1 CDS csgF NC_011741.1 1143531 1143947 R nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF complement(1143531..1143947) Escherichia coli IAI1 7125928 YP_002386530.1 CDS csgE NC_011741.1 1143972 1144361 R chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE complement(1143972..1144361) Escherichia coli IAI1 7125927 YP_002386531.1 CDS csgD NC_011741.1 1144366 1145016 R activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD complement(1144366..1145016) Escherichia coli IAI1 7125926 YP_002386532.1 CDS csgB NC_011741.1 1145770 1146225 D CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit 1145770..1146225 Escherichia coli IAI1 7125925 YP_002386533.1 CDS csgA NC_011741.1 1146266 1146721 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89201357, 93023873, 1677357, 8459772, 8817489, 1357528; Product type s : structure; cryptic curlin major subunit 1146266..1146721 Escherichia coli IAI1 7125923 YP_002386534.1 CDS csgC NC_011741.1 1146780 1147112 D involved in autoagglutination of curliated cells; not involved in production of curli fibers; putative autoagglutination protein 1146780..1147112 Escherichia coli IAI1 7125922 YP_002386535.1 CDS ymdA NC_011741.1 1147233 1147544 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1147233..1147544 Escherichia coli IAI1 7125924 YP_002386536.1 CDS ymdB NC_011741.1 1147639 1148172 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1147639..1148172 Escherichia coli IAI1 7126676 YP_002386537.1 CDS ymdC NC_011741.1 1148174 1149595 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 1148174..1149595 Escherichia coli IAI1 7126677 YP_002386538.1 CDS mdoC NC_011741.1 1149603 1150760 R required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein complement(1149603..1150760) Escherichia coli IAI1 7126678 YP_002386539.1 CDS ECIAI1_1082 NC_011741.1 1150805 1150948 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1150805..1150948) Escherichia coli IAI1 7127684 YP_002386540.1 CDS ECIAI1_1083 NC_011741.1 1150952 1151110 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1150952..1151110) Escherichia coli IAI1 7128640 YP_002386541.1 CDS mdoG NC_011741.1 1151154 1152689 D involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 1151154..1152689 Escherichia coli IAI1 7128641 YP_002386542.1 CDS mdoH NC_011741.1 1152682 1155225 D necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 1152682..1155225 Escherichia coli IAI1 7127686 YP_002386543.1 CDS yceK NC_011741.1 1155398 1155625 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 1155398..1155625 Escherichia coli IAI1 7127687 YP_002386544.1 CDS msyB NC_011741.1 1155626 1156000 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 92165719; hypothetical protein complement(1155626..1156000) Escherichia coli IAI1 7126687 YP_002386545.1 CDS mdtG NC_011741.1 1156083 1157309 R Confers resistance to fosfomycin and deoxycholate; drug efflux system protein MdtG complement(1156083..1157309) Escherichia coli IAI1 7124483 YP_002386546.1 CDS lpxL NC_011741.1 1157481 1158401 R Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase complement(1157481..1158401) Escherichia coli IAI1 7127694 YP_002386547.1 CDS yceA NC_011741.1 1158626 1159678 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1840644; hypothetical protein 1158626..1159678 Escherichia coli IAI1 7127628 YP_002386548.1 CDS yceI NC_011741.1 1159720 1160295 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15741337, 11298273, 1840644, 9298646; Product type c : carrier; hypothetical protein complement(1159720..1160295) Escherichia coli IAI1 7124773 YP_002386549.1 CDS yceJ NC_011741.1 1160299 1160865 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative cytochrome b561 complement(1160299..1160865) Escherichia coli IAI1 7124779 YP_002386550.1 CDS yceO NC_011741.1 1161126 1161266 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1161126..1161266) Escherichia coli IAI1 7124780 YP_002386551.1 CDS solA NC_011741.1 1161287 1162405 R catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase complement(1161287..1162405) Escherichia coli IAI1 7126177 YP_002386552.1 CDS bssS NC_011741.1 1162520 1162774 R BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS complement(1162520..1162774) Escherichia coli IAI1 7127948 YP_002386553.2 CDS dinI NC_011741.1 1163064 1163309 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11230150, 11152126; Product type f : factor; DNA damage-inducible protein I complement(1163064..1163309) Escherichia coli IAI1 7124422 YP_002386554.1 CDS pyrC NC_011741.1 1163383 1164429 R catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase complement(1163383..1164429) Escherichia coli IAI1 7124590 YP_002386555.1 CDS yceB NC_011741.1 1164535 1165095 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein complement(1164535..1165095) Escherichia coli IAI1 7126570 YP_002386556.1 CDS grxB NC_011741.1 1165229 1165876 R cofactor involved in the reduction of disulfides; glutaredoxin 2 complement(1165229..1165876) Escherichia coli IAI1 7124774 YP_002386557.1 CDS mdtH NC_011741.1 1165940 1167148 R Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH complement(1165940..1167148) Escherichia coli IAI1 7128469 YP_002386558.1 CDS rimJ NC_011741.1 1167384 1167968 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88121676, 90136529, 1356970; Product type e : enzyme; ribosomal-protein-S5-alanine N-acetyltransferase 1167384..1167968 Escherichia coli IAI1 7124146 YP_002386559.1 CDS yceH NC_011741.1 1167979 1168626 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1356970, 2828880; hypothetical protein 1167979..1168626 Escherichia coli IAI1 7125002 YP_002386560.1 CDS mviM NC_011741.1 1168628 1169551 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1168628..1169551 Escherichia coli IAI1 7124778 YP_002386561.1 CDS mviN NC_011741.1 1169661 1171196 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1169661..1171196 Escherichia coli IAI1 7124508 YP_002386562.1 CDS flgN NC_011741.1 1171236 1171652 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10320579; Product type f : factor; export chaperone for FlgK and FlgL complement(1171236..1171652) Escherichia coli IAI1 7124509 YP_002386563.1 CDS flgM NC_011741.1 1171657 1171950 R regulates the flagellar specific sigma28 transcription factor; anti-sigma28 factor FlgM complement(1171657..1171950) Escherichia coli IAI1 7127225 YP_002386564.1 CDS flgA NC_011741.1 1172026 1172685 R required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA complement(1172026..1172685) Escherichia coli IAI1 7127224 YP_002386565.1 CDS flgB NC_011741.1 1172840 1173256 D with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal body rod protein FlgB 1172840..1173256 Escherichia coli IAI1 7127211 YP_002386566.1 CDS flgC NC_011741.1 1173260 1173664 D with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 1173260..1173664 Escherichia coli IAI1 7127212 YP_002386567.1 CDS flgD NC_011741.1 1173676 1174371 D acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein 1173676..1174371 Escherichia coli IAI1 7127213 YP_002386568.1 CDS flgF NC_011741.1 1175620 1176375 D FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF 1175620..1176375 Escherichia coli IAI1 7127216 YP_002386569.1 CDS flgG NC_011741.1 1176513 1177295 D makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 1176513..1177295 Escherichia coli IAI1 7127217 YP_002386570.1 CDS flgH NC_011741.1 1177348 1178046 D part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 1177348..1178046 Escherichia coli IAI1 7127218 YP_002386571.1 CDS flgI NC_011741.1 1178058 1179155 D part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring protein 1178058..1179155 Escherichia coli IAI1 7127219 YP_002386572.1 CDS flgJ NC_011741.1 1179155 1180096 D Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 1179155..1180096 Escherichia coli IAI1 7127220 YP_002386573.1 CDS flgK NC_011741.1 1180162 1181805 D with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 1180162..1181805 Escherichia coli IAI1 7127221 YP_002386574.1 CDS flgL NC_011741.1 1181817 1182770 D with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; flagellar hook-associated protein FlgL 1181817..1182770 Escherichia coli IAI1 7127222 YP_002386575.1 CDS rne NC_011741.1 1182967 1186152 R bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E complement(1182967..1186152) Escherichia coli IAI1 7127223 YP_002386576.1 CDS rluC NC_011741.1 1186725 1187684 D catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 1186725..1187684 Escherichia coli IAI1 7125490 YP_002386577.1 CDS yceF NC_011741.1 1187796 1188380 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(1187796..1188380) Escherichia coli IAI1 7125011 YP_002386578.1 CDS yceD NC_011741.1 1188579 1189100 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 90008815, 1447160; hypothetical protein 1188579..1189100 Escherichia coli IAI1 7127968 YP_002386579.1 CDS rpmF NC_011741.1 1189152 1189325 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1189152..1189325 Escherichia coli IAI1 7124775 YP_002386580.1 CDS plsX NC_011741.1 1189406 1190476 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX 1189406..1190476 Escherichia coli IAI1 7128392 YP_002386581.1 CDS fabH NC_011741.1 1190544 1191497 D FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III 1190544..1191497 Escherichia coli IAI1 7126101 YP_002386582.1 CDS fabD NC_011741.1 1191513 1192442 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92052166, 92183950, 92210530, 92234941, 7700236, 7768883, 9298646; Product type e : enzyme; malonyl-CoA-[acyl-carrier-protein] transacylase 1191513..1192442 Escherichia coli IAI1 7127057 YP_002386583.1 CDS fabG NC_011741.1 1192455 1193189 D catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 1192455..1193189 Escherichia coli IAI1 7127054 YP_002386584.1 CDS acpP NC_011741.1 1193400 1193636 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1193400..1193636 Escherichia coli IAI1 7127056 YP_002386585.1 CDS fabF NC_011741.1 1193724 1194965 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 1193724..1194965 Escherichia coli IAI1 7125703 YP_002386586.1 CDS pabC NC_011741.1 1195085 1195894 D catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 1195085..1195894 Escherichia coli IAI1 7127055 YP_002386587.1 CDS yceG NC_011741.1 1195897 1196919 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 1195897..1196919 Escherichia coli IAI1 7124148 YP_002386588.1 CDS tmk NC_011741.1 1196909 1197550 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1196909..1197550 Escherichia coli IAI1 7124777 YP_002386589.1 CDS holB NC_011741.1 1197547 1198551 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1197547..1198551 Escherichia coli IAI1 7127454 YP_002386590.1 CDS ycfH NC_011741.1 1198562 1199359 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8505303, 8509334, 10747959; Product type pe : putative enzyme; putative metallodependent hydrolase 1198562..1199359 Escherichia coli IAI1 7125292 YP_002386591.1 CDS ptsG NC_011741.1 1199654 1201087 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunits IIBC 1199654..1201087 Escherichia coli IAI1 7127777 YP_002386592.1 CDS fhuE NC_011741.1 1201147 1203336 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90286919, 3032906, 10529396; Product type t : transporter; ferric-rhodotorulic acid outer membrane transporter complement(1201147..1203336) Escherichia coli IAI1 7126539 YP_002386593.1 CDS hinT NC_011741.1 1203670 1204029 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15703176, 10493123, 2162465; Product type e : enzyme; purine nucleoside phosphoramidase 1203670..1204029 Escherichia coli IAI1 7127102 YP_002386594.1 CDS ycfL NC_011741.1 1204032 1204409 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1204032..1204409 Escherichia coli IAI1 7128525 YP_002386595.1 CDS ycfM NC_011741.1 1204423 1205064 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein 1204423..1205064 Escherichia coli IAI1 7127779 YP_002386596.1 CDS thiK NC_011741.1 1205045 1205869 D catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 1205045..1205869 Escherichia coli IAI1 7127780 YP_002386597.1 CDS nagZ NC_011741.1 1205880 1206905 D hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1205880..1206905 Escherichia coli IAI1 7127781 YP_002386598.1 CDS ycfP NC_011741.1 1206928 1207470 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1206928..1207470 Escherichia coli IAI1 7124522 YP_002386599.1 CDS ndh NC_011741.1 1207878 1209182 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14766919, 20130027, 81256452, 92296775, 94042945, 99441207, 6265208; Product type e : enzyme; respiratory NADH dehydrogenase 2/cupric reductase 1207878..1209182 Escherichia coli IAI1 7127782 YP_002386600.1 CDS ycfJ NC_011741.1 1209392 1209931 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6265208, 7984428; hypothetical protein 1209392..1209931 Escherichia coli IAI1 7127863 YP_002386601.1 CDS ycfQ NC_011741.1 1209993 1210625 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1209993..1210625) Escherichia coli IAI1 7127778 YP_002386602.1 CDS ycfR NC_011741.1 1210866 1211123 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089; hypothetical protein 1210866..1211123 Escherichia coli IAI1 7127783 YP_002386603.1 CDS ycfS NC_011741.1 1211206 1212168 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1211206..1212168) Escherichia coli IAI1 7127784 YP_002386604.1 CDS mfd NC_011741.1 1212312 1215758 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14602898, 90158497, 92107993, 8465200; Product type f : factor; transcription-repair coupling factor complement(1212312..1215758) Escherichia coli IAI1 7127785 YP_002386605.1 CDS ycfT NC_011741.1 1215886 1216959 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1215886..1216959) Escherichia coli IAI1 7124256 YP_002386606.1 CDS lolC NC_011741.1 1217221 1218420 D part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC 1217221..1218420 Escherichia coli IAI1 7127786 YP_002386607.1 CDS lolD NC_011741.1 1218413 1219114 D outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding subunit 1218413..1219114 Escherichia coli IAI1 7126435 YP_002386608.1 CDS lolE NC_011741.1 1219114 1220358 D part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1219114..1220358 Escherichia coli IAI1 7126436 YP_002386609.1 CDS ycfX NC_011741.1 1220387 1221298 D catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 1220387..1221298 Escherichia coli IAI1 7126437 YP_002386610.1 CDS cobB NC_011741.1 1221314 1222135 D Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1221314..1222135 Escherichia coli IAI1 7127787 YP_002386611.1 CDS ycfZ NC_011741.1 1222274 1222996 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1222274..1222996) Escherichia coli IAI1 7126345 YP_002386612.1 CDS ECIAI1_1159 NC_011741.1 1223059 1223529 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1223059..1223529) Escherichia coli IAI1 7127788 YP_002386613.1 CDS potD NC_011741.1 1223578 1224624 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter periplasmic substrate-binding protein complement(1223578..1224624) Escherichia coli IAI1 7128642 YP_002386614.1 CDS potC NC_011741.1 1224621 1225415 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein complement(1224621..1225415) Escherichia coli IAI1 7126116 YP_002386615.1 CDS potB NC_011741.1 1225412 1226239 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein complement(1225412..1226239) Escherichia coli IAI1 7126115 YP_002386616.1 CDS potA NC_011741.1 1226253 1227389 R functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase complement(1226253..1227389) Escherichia coli IAI1 7126114 YP_002386617.1 CDS ECIAI1_1164 NC_011741.1 1227368 1227619 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1227368..1227619) Escherichia coli IAI1 7126113 YP_002386618.1 CDS pepT NC_011741.1 1227597 1228868 D catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1227597..1228868 Escherichia coli IAI1 7128643 YP_002386619.1 CDS ycfD NC_011741.1 1229014 1230135 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1229014..1230135) Escherichia coli IAI1 7124176 YP_002386620.1 CDS phoQ NC_011741.1 1230211 1231671 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92105017; Product type r : regulator; sensor protein PhoQ complement(1230211..1231671) Escherichia coli IAI1 7127776 YP_002386621.1 CDS phoP NC_011741.1 1231671 1232342 R response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP complement(1231671..1232342) Escherichia coli IAI1 7124219 YP_002386622.1 CDS purB NC_011741.1 1232510 1233880 R Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase complement(1232510..1233880) Escherichia coli IAI1 7124218 YP_002386623.1 CDS hflD NC_011741.1 1233884 1234525 R HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein complement(1233884..1234525) Escherichia coli IAI1 7126545 YP_002386624.1 CDS mnmA NC_011741.1 1234561 1235667 R catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA complement(1234561..1235667) Escherichia coli IAI1 7128519 YP_002386625.1 CDS ymfB NC_011741.1 1235721 1236182 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217; Product type e : enzyme; bifunctional thiamin pyrimidine pyrophosphate hydrolase and thiamin pyrophosphate hydrolase complement(1235721..1236182) Escherichia coli IAI1 7127493 YP_002386626.1 CDS ymfC NC_011741.1 1236192 1236845 R catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E complement(1236192..1236845) Escherichia coli IAI1 7126680 YP_002386627.1 CDS icd NC_011741.1 1237017 1238267 D Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1237017..1238267 Escherichia coli IAI1 7126681 YP_002386628.1 CDS ycgX NC_011741.1 1239389 1239793 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1239389..1239793) Escherichia coli IAI1 7126043 YP_002386629.1 CDS ycgE NC_011741.1 1240014 1240745 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1240014..1240745) Escherichia coli IAI1 7127801 YP_002386630.1 CDS ECIAI1_1177 NC_011741.1 1240655 1240807 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1240655..1240807) Escherichia coli IAI1 7127790 YP_002386631.1 CDS ycgF NC_011741.1 1240950 1242161 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16533062, 15453820; Product type pe : putative enzyme; putative cyclic di-GMP phosphodiesterase complement(1240950..1242161) Escherichia coli IAI1 7128644 YP_002386632.1 CDS ycgZ NC_011741.1 1242475 1242711 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1242475..1242711 Escherichia coli IAI1 7127791 YP_002386633.1 CDS ymgA NC_011741.1 1242754 1243026 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1242754..1243026 Escherichia coli IAI1 7127803 YP_002386634.1 CDS ymgB NC_011741.1 1243055 1243321 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1243055..1243321 Escherichia coli IAI1 7126682 YP_002386635.1 CDS ymgC NC_011741.1 1243434 1243682 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1243434..1243682 Escherichia coli IAI1 7126683 YP_002386636.1 CDS ycgG NC_011741.1 1244014 1245537 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1244014..1245537 Escherichia coli IAI1 7126684 YP_002386637.1 CDS ymgF NC_011741.1 1245669 1245887 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1245669..1245887 Escherichia coli IAI1 7127792 YP_002386638.1 CDS ECIAI1_1185 NC_011741.1 1246287 1246496 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1246287..1246496 Escherichia coli IAI1 7127613 YP_002386639.1 CDS ECIAI1_1186 NC_011741.1 1246613 1248934 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane autotransporter barrel pectin lyase fold 1246613..1248934 Escherichia coli IAI1 7128645 YP_002386640.1 CDS ymgD NC_011741.1 1248991 1249320 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1248991..1249320) Escherichia coli IAI1 7128646 YP_002386641.1 CDS ymgG NC_011741.1 1249330 1249605 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1249330..1249605) Escherichia coli IAI1 7126685 YP_002386642.1 CDS ECIAI1_1189 NC_011741.1 1250151 1250594 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1250151..1250594 Escherichia coli IAI1 7127532 YP_002386643.1 CDS minE NC_011741.1 1250966 1251232 R works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE complement(1250966..1251232) Escherichia coli IAI1 7128647 YP_002386644.1 CDS minD NC_011741.1 1251236 1252048 R ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD complement(1251236..1252048) Escherichia coli IAI1 7124277 YP_002386645.1 CDS minC NC_011741.1 1252072 1252767 R blocks the formation of polar Z-ring septums; septum formation inhibitor complement(1252072..1252767) Escherichia coli IAI1 7124276 YP_002386646.1 CDS ycgJ NC_011741.1 1253287 1253655 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1253287..1253655 Escherichia coli IAI1 7124275 YP_002386647.1 CDS ycgK NC_011741.1 1253775 1254176 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1253775..1254176) Escherichia coli IAI1 7127793 YP_002386648.1 CDS ycgL NC_011741.1 1254385 1254711 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1254385..1254711 Escherichia coli IAI1 7127794 YP_002386649.1 CDS ycgM NC_011741.1 1254783 1255442 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15551868; Product type pe : putative enzyme; hypothetical protein 1254783..1255442 Escherichia coli IAI1 7127795 YP_002386650.1 CDS ycgN NC_011741.1 1255534 1255980 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1255534..1255980 Escherichia coli IAI1 7127796 YP_002386651.1 CDS umuD NC_011741.1 1257470 1257889 D binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1257470..1257889 Escherichia coli IAI1 7124432 YP_002386652.1 CDS umuC NC_011741.1 1257889 1259157 D binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1257889..1259157 Escherichia coli IAI1 7125544 YP_002386653.1 CDS dsbB NC_011741.1 1259203 1259733 R disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B complement(1259203..1259733) Escherichia coli IAI1 7125543 YP_002386654.1 CDS nhaB NC_011741.1 1259879 1261420 R involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter complement(1259879..1261420) Escherichia coli IAI1 7124623 YP_002386655.1 CDS fadR NC_011741.1 1261642 1262361 D Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1261642..1262361 Escherichia coli IAI1 7127874 YP_002386656.1 CDS ycgB NC_011741.1 1262413 1263945 R Evidence 4 : Homologs of previously reported genes of unknown function; SpoVR family protein complement(1262413..1263945) Escherichia coli IAI1 7127067 YP_002386657.1 CDS dadA NC_011741.1 1264275 1265573 D catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1264275..1265573 Escherichia coli IAI1 7127789 YP_002386658.1 CDS dadX NC_011741.1 1265583 1266653 D catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA; alanine racemase 1265583..1266653 Escherichia coli IAI1 7126912 YP_002386659.1 CDS cvrA NC_011741.1 1267039 1268775 R the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter complement(1267039..1268775) Escherichia coli IAI1 7126913 YP_002386660.1 CDS ldcA NC_011741.1 1268870 1269784 R catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A complement(1268870..1269784) Escherichia coli IAI1 7126868 YP_002386661.1 CDS emtA NC_011741.1 1269884 1270495 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98317285; Product type e : enzyme; lytic murein endotransglycosylase E 1269884..1270495 Escherichia coli IAI1 7126397 YP_002386662.1 CDS ycgR NC_011741.1 1270497 1271231 R Evidence 2b : Function of strongly homologous gene; PubMedId : 11031114; Product type cp : cell process; flagellar function protein complement(1270497..1271231) Escherichia coli IAI1 7125065 YP_002386663.1 CDS ymgE NC_011741.1 1271432 1271686 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative inner membrane protein with transglycosylase-associated domain 1271432..1271686 Escherichia coli IAI1 7127798 YP_002386664.1 CDS ycgY NC_011741.1 1271864 1272304 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1271864..1272304 Escherichia coli IAI1 7126686 YP_002386665.1 CDS treA NC_011741.1 1272383 1274080 R periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell; trehalase complement(1272383..1274080) Escherichia coli IAI1 7127802 YP_002386666.1 CDS dhaH NC_011741.1 1274400 1275818 R phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL; dihydroxyacetone kinase subunit M complement(1274400..1275818) Escherichia coli IAI1 7127479 YP_002386667.1 CDS dhaL NC_011741.1 1275829 1276461 R with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL complement(1275829..1276461) Escherichia coli IAI1 7124579 YP_002386668.1 CDS dhaK NC_011741.1 1276472 1277542 R with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK complement(1276472..1277542) Escherichia coli IAI1 7124581 YP_002386669.1 CDS dhaR NC_011741.1 1277770 1279689 D Positively regulates the dhaKLM operon from a sigma-70 promoter; DNA-binding transcriptional regulator DhaR 1277770..1279689 Escherichia coli IAI1 7124580 YP_002386670.1 CDS ychF NC_011741.1 1283498 1284589 R translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD complement(1283498..1284589) Escherichia coli IAI1 7127800 YP_002386671.1 CDS pth NC_011741.1 1284706 1285290 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(1284706..1285290) Escherichia coli IAI1 7127806 YP_002386672.1 CDS ychH NC_011741.1 1285568 1285846 D YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 1285568..1285846 Escherichia coli IAI1 7126535 YP_002386673.1 CDS ychM NC_011741.1 1285901 1287580 R putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; putative sulfate transporter YchM complement(1285901..1287580) Escherichia coli IAI1 7127807 YP_002386674.1 CDS prsA NC_011741.1 1287705 1288652 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(1287705..1288652) Escherichia coli IAI1 7127809 YP_002386675.1 CDS ipk NC_011741.1 1288803 1289654 R An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase complement(1288803..1289654) Escherichia coli IAI1 7126171 YP_002386676.1 CDS lolB NC_011741.1 1289654 1290277 R Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB complement(1289654..1290277) Escherichia coli IAI1 7126082 YP_002386677.1 CDS hemA NC_011741.1 1290491 1291747 D catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1290491..1291747 Escherichia coli IAI1 7126434 YP_002386678.1 CDS prfA NC_011741.1 1291789 1292871 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1291789..1292871 Escherichia coli IAI1 7128505 YP_002386679.1 CDS prmC NC_011741.1 1292871 1293704 D HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1292871..1293704 Escherichia coli IAI1 7126144 YP_002386680.1 CDS ychQ NC_011741.1 1293701 1294093 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10322010; Product type pr : putative regulator; putative transcriptional regulator 1293701..1294093 Escherichia coli IAI1 7126155 YP_002386681.1 CDS ychA NC_011741.1 1294097 1294906 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10322010; Product type pr : putative regulator; putative transcriptional regulator 1294097..1294906 Escherichia coli IAI1 7127812 YP_002386682.1 CDS kdsA NC_011741.1 1294942 1295796 D catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1294942..1295796 Escherichia coli IAI1 7127804 YP_002386683.1 CDS ldrB NC_011741.1 1295945 1296052 R Evidence 1b : Function experimentally demonstrated in the studied species; Product type f : factor; toxic polypeptide, small complement(1295945..1296052) Escherichia coli IAI1 7126378 YP_002386684.1 CDS chaA NC_011741.1 1296457 1297557 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93266586, 94193576, 94292460; Product type t : transporter; calcium/sodium:proton antiporter complement(1296457..1297557) Escherichia coli IAI1 7126604 YP_002386685.1 CDS chaB NC_011741.1 1297827 1298057 D in Escherichia coli this protein putatively regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1297827..1298057 Escherichia coli IAI1 7126300 YP_002386686.1 CDS chaC NC_011741.1 1298194 1298910 D Evidence 1b : Function experimentally demonstrated in the studied species; Product type r : regulator; regulatory protein for cation transport 1298194..1298910 Escherichia coli IAI1 7126301 YP_002386687.1 CDS ychN NC_011741.1 1298954 1299307 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1298954..1299307) Escherichia coli IAI1 7126302 YP_002386688.1 CDS ychP NC_011741.1 1299633 1300886 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pf : putative factor; hypothetical protein 1299633..1300886 Escherichia coli IAI1 7127810 YP_002386689.1 CDS narL NC_011741.1 1300887 1301537 R two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL complement(1300887..1301537) Escherichia coli IAI1 7127811 YP_002386690.1 CDS narX NC_011741.1 1301530 1303326 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92276349, 92374842, 94083940, 2649492, 2657652, 2668029; Product type r : regulator; nitrate/nitrite sensor protein NarX complement(1301530..1303326) Escherichia coli IAI1 7124540 YP_002386691.1 CDS ECIAI1_1245 NC_011741.1 1303352 1303570 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1303352..1303570 Escherichia coli IAI1 7127860 YP_002386692.1 CDS narK NC_011741.1 1303665 1305056 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91258310, 2657652, 2668029; Product type t : transporter; nitrate/nitrite transporter 1303665..1305056 Escherichia coli IAI1 7128648 YP_002386693.1 CDS narG NC_011741.1 1305572 1309315 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 74167294, 89384449, 92121125, 2233673, 2668029, 2995309, 3053688, 3308846, 6094247; Product type e : enzyme; nitrate reductase 1 subunit alpha 1305572..1309315 Escherichia coli IAI1 7124539 YP_002386694.1 CDS narH NC_011741.1 1309312 1310850 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 74167294, 89384449, 92121125, 1321049, 2832376, 3053688, 8383531, 8388253, 8664273, 9516445; Product type c : carrier; nitrate reductase 1, beta (Fe-S) subunit 1309312..1310850 Escherichia coli IAI1 7124535 YP_002386695.1 CDS narJ NC_011741.1 1310847 1311557 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89384449, 92121125, 9632249, 2832376; Product type f : factor; molybdenum-cofactor-assembly chaperone subunit (delta subunit) of nitrate reductase 1 1310847..1311557 Escherichia coli IAI1 7124536 YP_002386696.1 CDS narI NC_011741.1 1311557 1312234 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 75114694, 89384449, 92121125, 2832376, 3053688; Product type c : carrier; nitrate reductase 1, gamma (cytochrome b(NR)) subunit 1311557..1312234 Escherichia coli IAI1 7124538 YP_002386697.1 CDS purU NC_011741.1 1312960 1313802 R produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase complement(1312960..1313802) Escherichia coli IAI1 7128055 YP_002386698.1 CDS ychJ NC_011741.1 1313852 1314310 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1313852..1314310) Escherichia coli IAI1 7126557 YP_002386699.1 CDS rssA NC_011741.1 1314384 1315328 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 1314384..1315328 Escherichia coli IAI1 7127808 YP_002386700.1 CDS rssB NC_011741.1 1315420 1316433 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339606, 12912910, 9495753; Product type r : regulator; response regulator of RpoS 1315420..1316433 Escherichia coli IAI1 7128442 YP_002386701.1 CDS galU NC_011741.1 1316635 1317543 D together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalU 1316635..1317543 Escherichia coli IAI1 7128443 YP_002386702.1 CDS hns NC_011741.1 1317687 1318100 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 94335643, 95267838, 95286558, 99355427, 2404280, 11298273; Product type r : regulator; global DNA-binding transcriptional dual regulator H-NS complement(1317687..1318100) Escherichia coli IAI1 7128276 YP_002386703.1 CDS tdk NC_011741.1 1318705 1319322 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1318705..1319322 Escherichia coli IAI1 7125286 YP_002386704.1 CDS adhE NC_011741.1 1319624 1322299 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12783863, 4301680, 89291706, 91200315; Product type e : enzyme; bifunctional acetaldehyde-CoA/alcohol dehydrogenase complement(1319624..1322299) Escherichia coli IAI1 7126233 YP_002386705.1 CDS ychE NC_011741.1 1322776 1323423 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1322776..1323423 Escherichia coli IAI1 7125717 YP_002386706.1 CDS ECIAI1_1261 NC_011741.1 1323581 1323895 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1323581..1323895) Escherichia coli IAI1 7127805 YP_002386707.1 CDS oppA NC_011741.1 1324161 1325792 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20256410, 86111605, 90256748, 92325017, 2015910, 9298646, 9600841, 2187863, 8740179, 9740056, 10972807; Product type t : transporter; oligopeptide ABC transporter periplasmic-binding protein 1324161..1325792 Escherichia coli IAI1 7128649 YP_002386708.1 CDS oppB NC_011741.1 1325878 1326798 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606, 93106975, 2187863; Product type t : transporter; oligopeptide transporter permease 1325878..1326798 Escherichia coli IAI1 7125989 YP_002386709.1 CDS oppC NC_011741.1 1326813 1327721 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide ABC transporter membrane protein 1326813..1327721 Escherichia coli IAI1 7125990 YP_002386710.1 CDS oppD NC_011741.1 1327733 1328746 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide transporter ATP-binding protein 1327733..1328746 Escherichia coli IAI1 7125991 YP_002386711.1 CDS oppF NC_011741.1 1328743 1329747 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide ABC transporter ATP-binding protein 1328743..1329747 Escherichia coli IAI1 7125992 YP_002386712.1 CDS yciU NC_011741.1 1329800 1330129 R highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein complement(1329800..1330129) Escherichia coli IAI1 7125993 YP_002386713.1 CDS cls NC_011741.1 1330164 1331624 R catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase complement(1330164..1331624) Escherichia coli IAI1 7127827 YP_002386714.1 CDS ECIAI1_1269 NC_011741.1 1331656 1331940 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1331656..1331940 Escherichia coli IAI1 7126337 YP_002386715.1 CDS kch NC_011741.1 1331995 1333248 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12220501, 12912904, 94224769, 98319474; Product type t : transporter; voltage-gated potassium channel complement(1331995..1333248) Escherichia coli IAI1 7128650 YP_002386716.1 CDS yciI NC_011741.1 1333548 1333844 R unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; YciI-like protein complement(1333548..1333844) Escherichia coli IAI1 7126178 YP_002386717.1 CDS tonB NC_011741.1 1334068 1334787 D membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transport protein TonB 1334068..1334787 Escherichia coli IAI1 7127821 YP_002386718.1 CDS yciA NC_011741.1 1334827 1335225 R YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins; acyl-CoA thioester hydrolase complement(1334827..1335225) Escherichia coli IAI1 7127463 YP_002386719.1 CDS yciB NC_011741.1 1335330 1335869 R Involved in cell division; probably involved in intracellular septation; intracellular septation protein A complement(1335330..1335869) Escherichia coli IAI1 7127814 YP_002386720.1 CDS yciC NC_011741.1 1335899 1336642 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1335899..1336642) Escherichia coli IAI1 7127815 YP_002386721.1 CDS ompW NC_011741.1 1336999 1337637 D receptor for colicin S4; outer membrane protein W 1336999..1337637 Escherichia coli IAI1 7127816 YP_002386722.1 CDS yciE NC_011741.1 1337697 1338203 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15388941, 3058546, 8455549; hypothetical protein complement(1337697..1338203) Escherichia coli IAI1 7125985 YP_002386723.1 CDS yciF NC_011741.1 1338249 1338749 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3058546, 8455549; hypothetical protein complement(1338249..1338749) Escherichia coli IAI1 7127817 YP_002386724.1 CDS yciG NC_011741.1 1338835 1339014 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1338835..1339014) Escherichia coli IAI1 7127818 YP_002386725.1 CDS trpA NC_011741.1 1339395 1340201 R catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha complement(1339395..1340201) Escherichia coli IAI1 7127819 YP_002386726.1 CDS trpB NC_011741.1 1340201 1341394 R catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta complement(1340201..1341394) Escherichia coli IAI1 7127494 YP_002386727.1 CDS trpC NC_011741.1 1341406 1342764 R monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase complement(1341406..1342764) Escherichia coli IAI1 7127495 YP_002386728.1 CDS trpD NC_011741.1 1342768 1344363 R bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase complement(1342768..1344363) Escherichia coli IAI1 7127496 YP_002386729.1 CDS trpE NC_011741.1 1344363 1345925 R with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I complement(1344363..1345925) Escherichia coli IAI1 7127497 YP_002386731.1 CDS yciV NC_011741.1 1346199 1347080 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1346199..1347080 Escherichia coli IAI1 7127499 YP_002386732.1 CDS yciO NC_011741.1 1347077 1347697 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1347077..1347697 Escherichia coli IAI1 7127828 YP_002386733.1 CDS rluB NC_011741.1 1347771 1348670 D catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1347771..1348670 Escherichia coli IAI1 7127825 YP_002386734.1 CDS btuR NC_011741.1 1348710 1349300 R catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase complement(1348710..1349300) Escherichia coli IAI1 7125010 YP_002386735.1 CDS yciK NC_011741.1 1349297 1350055 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; short chain dehydrogenase complement(1349297..1350055) Escherichia coli IAI1 7124428 YP_002386736.1 CDS ECIAI1_1290 NC_011741.1 1350099 1350263 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1350099..1350263) Escherichia coli IAI1 7127822 YP_002386737.1 CDS sohB NC_011741.1 1350275 1351324 D SohB; periplasmic protein; member of the peptidase S49 family; putative periplasmic protease 1350275..1351324 Escherichia coli IAI1 7128651 YP_002386738.1 CDS yciN NC_011741.1 1351360 1351611 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3029379, 7567469, 9868784; hypothetical protein complement(1351360..1351611) Escherichia coli IAI1 7127945 YP_002386739.1 CDS ECIAI1_1293 NC_011741.1 1351656 1351868 D Evidence 6 : Doubtful CDS; hypothetical protein 1351656..1351868 Escherichia coli IAI1 7127824 YP_002386740.1 CDS topA NC_011741.1 1351991 1354588 D catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1351991..1354588 Escherichia coli IAI1 7128652 YP_002386741.1 CDS cysB NC_011741.1 1354798 1355772 D LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1354798..1355772 Escherichia coli IAI1 7127464 YP_002386742.1 CDS ECIAI1_1296 NC_011741.1 1356066 1356230 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1356066..1356230 Escherichia coli IAI1 7126888 YP_002386743.1 CDS ECIAI1_1297 NC_011741.1 1356212 1356400 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1356212..1356400 Escherichia coli IAI1 7128653 YP_002386744.1 CDS ECIAI1_1298 NC_011741.1 1356537 1356719 D Evidence 6 : Doubtful CDS; hypothetical protein 1356537..1356719 Escherichia coli IAI1 7128654 YP_002386745.1 CDS acnA NC_011741.1 1356773 1359448 D Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1356773..1359448 Escherichia coli IAI1 7128655 YP_002386746.1 CDS ribA NC_011741.1 1359512 1360102 R catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II complement(1359512..1360102) Escherichia coli IAI1 7125700 YP_002386747.1 CDS pgpB NC_011741.1 1360272 1361036 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89033893, 92104964; Product type e : enzyme; phosphatidylglycerophosphatase B 1360272..1361036 Escherichia coli IAI1 7124992 YP_002386748.1 CDS yciS NC_011741.1 1361185 1361493 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1361185..1361493 Escherichia coli IAI1 7124190 YP_002386749.1 CDS yciM NC_011741.1 1361500 1362669 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1361500..1362669 Escherichia coli IAI1 7127826 YP_002386750.1 CDS pyrF NC_011741.1 1362862 1363599 D type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1362862..1363599 Escherichia coli IAI1 7127823 YP_002386751.1 CDS yciH NC_011741.1 1363599 1363925 D involved in start site selection during the initiation of translation; translation initiation factor Sui1 1363599..1363925 Escherichia coli IAI1 7126573 YP_002386752.1 CDS ECIAI1_1306 NC_011741.1 1363949 1364101 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1363949..1364101 Escherichia coli IAI1 7127820 YP_002386753.1 CDS osmB NC_011741.1 1364051 1364269 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92078100, 2644204; Product type lp : lipoprotein; lipoprotein complement(1364051..1364269) Escherichia coli IAI1 7128656 YP_002386754.1 CDS deoT NC_011741.1 1364538 1365287 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16451192; Product type r : regulator; DNA-binding transcriptional repressor, DeoR family complement(1364538..1365287) Escherichia coli IAI1 7125995 YP_002386755.1 CDS ECIAI1_1309 NC_011741.1 1365377 1365592 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1365377..1365592) Escherichia coli IAI1 7124568 YP_002386756.1 CDS gmr NC_011741.1 1365697 1367682 R c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP; RNase II stability modulator complement(1365697..1367682) Escherichia coli IAI1 7128657 YP_002386757.1 CDS rnb NC_011741.1 1367918 1369852 R Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II complement(1367918..1369852) Escherichia coli IAI1 7128364 YP_002386758.1 CDS yciW NC_011741.1 1369920 1371047 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amidase or amidotransferase complement(1369920..1371047) Escherichia coli IAI1 7125016 YP_002386759.1 CDS fabI NC_011741.1 1371192 1371980 R Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase complement(1371192..1371980) Escherichia coli IAI1 7127829 YP_002386760.1 CDS ycjD NC_011741.1 1372348 1372701 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1372348..1372701) Escherichia coli IAI1 7127058 YP_002386761.1 CDS sapF NC_011741.1 1372769 1373575 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 10720487, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter ATP-binding protein complement(1372769..1373575) Escherichia coli IAI1 7127830 YP_002386762.1 CDS sapD NC_011741.1 1373577 1374569 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 10720487, 9634580, 1987159; Product type t : transporter; antimicrobial peptide ABC transporter ATP-binding protein complement(1373577..1374569) Escherichia coli IAI1 7124674 YP_002386763.1 CDS sapC NC_011741.1 1374569 1375459 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter permease complement(1374569..1375459) Escherichia coli IAI1 7124673 YP_002386764.1 CDS sapB NC_011741.1 1375446 1376411 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter permease complement(1375446..1376411) Escherichia coli IAI1 7124672 YP_002386765.1 CDS sapA NC_011741.1 1376408 1378051 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter periplasmic-binding protein complement(1376408..1378051) Escherichia coli IAI1 7124671 YP_002386766.1 CDS ymjA NC_011741.1 1378363 1378608 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1378363..1378608) Escherichia coli IAI1 7124670 YP_002386767.1 CDS puuP NC_011741.1 1378742 1380127 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15590624; Product type t : transporter; putrescine importer complement(1378742..1380127) Escherichia coli IAI1 7127533 YP_002386768.1 CDS puuA NC_011741.1 1380430 1381848 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15590624; Product type e : enzyme; gamma-Glu-putrescine synthase complement(1380430..1381848) Escherichia coli IAI1 7126565 YP_002386769.1 CDS puuD NC_011741.1 1382060 1382824 D catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate; gamma-glutamyl-gamma-aminobutyrate hydrolase 1382060..1382824 Escherichia coli IAI1 7126560 YP_002386770.1 CDS puuR NC_011741.1 1382851 1383408 D regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR 1382851..1383408 Escherichia coli IAI1 7126563 YP_002386771.1 CDS puuC NC_011741.1 1383683 1385170 D catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation; gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 1383683..1385170 Escherichia coli IAI1 7126566 YP_002386772.1 CDS puuB NC_011741.1 1385172 1386452 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150200, 15590624; Product type e : enzyme; gamma-Glu-putrescine oxidase 1385172..1386452 Escherichia coli IAI1 7126562 YP_002386773.1 CDS puuE NC_011741.1 1386490 1387755 D putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate; 4-aminobutyrate transaminase 1386490..1387755 Escherichia coli IAI1 7126561 YP_002386774.1 CDS pspF NC_011741.1 1387875 1388852 R transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator complement(1387875..1388852) Escherichia coli IAI1 7126564 YP_002386775.1 CDS pspA NC_011741.1 1389019 1389687 D involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 1389019..1389687 Escherichia coli IAI1 7126528 YP_002386776.1 CDS pspB NC_011741.1 1389741 1389965 D acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B 1389741..1389965 Escherichia coli IAI1 7126174 YP_002386777.1 CDS pspC NC_011741.1 1389965 1390324 D with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; DNA-binding transcriptional activator PspC 1389965..1390324 Escherichia coli IAI1 7126175 YP_002386778.1 CDS pspD NC_011741.1 1390333 1390554 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91295203, 97303082; Product type ph : phenotype; peripheral inner membrane phage-shock protein 1390333..1390554 Escherichia coli IAI1 7126176 YP_002386779.1 CDS pspE NC_011741.1 1390629 1390943 D rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 1390629..1390943 Escherichia coli IAI1 7126445 YP_002386780.1 CDS ycjM NC_011741.1 1391155 1392834 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glucosyltransferase 1391155..1392834 Escherichia coli IAI1 7126527 YP_002386781.1 CDS ycjN NC_011741.1 1392848 1394140 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter periplasmic-binding protein 1392848..1394140 Escherichia coli IAI1 7127833 YP_002386782.1 CDS ycjO NC_011741.1 1394161 1395042 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter permease 1394161..1395042 Escherichia coli IAI1 7127834 YP_002386783.1 CDS ycjP NC_011741.1 1395029 1395871 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter permease 1395029..1395871 Escherichia coli IAI1 7127835 YP_002386784.1 CDS ycjQ NC_011741.1 1395902 1396954 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1395902..1396954 Escherichia coli IAI1 7127836 YP_002386785.1 CDS ycjR NC_011741.1 1396972 1397760 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative isomerase/epimerase 1396972..1397760 Escherichia coli IAI1 7127837 YP_002386786.1 CDS ycjS NC_011741.1 1397770 1398825 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1397770..1398825 Escherichia coli IAI1 7127838 YP_002386787.1 CDS ycjT NC_011741.1 1398822 1401089 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl hydrolase/phosphorylase 1398822..1401089 Escherichia coli IAI1 7127839 YP_002386788.1 CDS ycjU NC_011741.1 1401086 1401745 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11972617; Product type pe : putative enzyme; putative glucose-1-phosphate phosphodismutase, beta-phosphoglucomutase 1401086..1401745 Escherichia coli IAI1 7127840 YP_002386789.1 CDS ycjV NC_011741.1 1401759 1402841 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter ATP-binding protein 1401759..1402841 Escherichia coli IAI1 7127841 YP_002386790.1 CDS ompG NC_011741.1 1402886 1403791 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20464934, 89327119, 9721282; Product type t : transporter; outer membrane porin 1402886..1403791 Escherichia coli IAI1 7127842 YP_002386791.1 CDS ycjW NC_011741.1 1403902 1404900 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1403902..1404900) Escherichia coli IAI1 7125981 YP_002386792.1 CDS ycjX NC_011741.1 1405055 1406452 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1405055..1406452 Escherichia coli IAI1 7127843 YP_002386793.1 CDS ycjF NC_011741.1 1406449 1407510 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1406449..1407510 Escherichia coli IAI1 7127844 YP_002386794.1 CDS tyrR NC_011741.1 1407658 1409199 D regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1407658..1409199 Escherichia coli IAI1 7127831 YP_002386795.1 CDS tpx NC_011741.1 1409243 1409749 R antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase complement(1409243..1409749) Escherichia coli IAI1 7127528 YP_002386796.1 CDS ycjG NC_011741.1 1409868 1410833 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11747447, 11747448, 7499381; Product type e : enzyme; L-Ala-D/L-Glu epimerase 1409868..1410833 Escherichia coli IAI1 7127478 YP_002386797.1 CDS mpaA NC_011741.1 1410808 1411596 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12511517; Product type e : enzyme; murein peptide amidase A complement(1410808..1411596) Escherichia coli IAI1 7127832 YP_002386798.1 CDS ymjC NC_011741.1 1411827 1412477 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P) binding enzyme complement(1411827..1412477) Escherichia coli IAI1 7124462 YP_002386799.1 CDS ECIAI1_1355 NC_011741.1 1414086 1414253 R hypothetical protein complement(1414086..1414253) Escherichia coli IAI1 7127846 YP_002386800.1 CDS ycjZ NC_011741.1 1414473 1415372 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17366475; Product type pr : putative regulator; putative nucleic acid-binding regulator 1414473..1415372 Escherichia coli IAI1 7127847 YP_002386801.1 CDS mppA NC_011741.1 1415709 1417322 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438753, 9495761; Product type t : transporter; murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) ABC transporter periplasmic-binding protein 1415709..1417322 Escherichia coli IAI1 7127848 YP_002386802.1 CDS ynaI NC_011741.1 1417373 1418404 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1417373..1418404) Escherichia coli IAI1 7124464 YP_002386803.1 CDS ynaJ NC_011741.1 1418648 1418905 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1418648..1418905 Escherichia coli IAI1 7127535 YP_002386804.1 CDS uspE NC_011741.1 1418955 1419905 R with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE complement(1418955..1419905) Escherichia coli IAI1 7127536 YP_002386805.1 CDS fnr NC_011741.1 1420057 1420809 R Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator complement(1420057..1420809) Escherichia coli IAI1 7125551 YP_002386806.1 CDS ogt NC_011741.1 1421004 1421519 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88067749, 91161525, 94252990, 98125595, 1520330; Product type e : enzyme; O-6-alkylguanine-DNA:cysteine-protein methyltransferase complement(1421004..1421519) Escherichia coli IAI1 7127255 YP_002386807.1 CDS abgT NC_011741.1 1421530 1422870 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9829935, 2825131, 7567469; Product type t : transporter; putative aminobenzoyl-glutamate transporter complement(1421530..1422870) Escherichia coli IAI1 7125977 YP_002386808.1 CDS ECIAI1_1365 NC_011741.1 1422985 1423176 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1422985..1423176) Escherichia coli IAI1 7125688 YP_002386809.1 CDS abgB NC_011741.1 1423089 1424534 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9829935; Product type pe : putative enzyme; putative peptidase, aminobenzoyl-glutamate utilization protein complement(1423089..1424534) Escherichia coli IAI1 7128659 YP_002386810.1 CDS abgA NC_011741.1 1424534 1425844 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9829935; Product type pe : putative enzyme; putative peptidase, para-aminobenzoyl-glutamate utilization protein complement(1424534..1425844) Escherichia coli IAI1 7125686 YP_002386811.1 CDS abgR NC_011741.1 1426020 1426928 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9829935; Product type r : regulator; putative DNA-binding transcriptional regulator 1426020..1426928 Escherichia coli IAI1 7125685 YP_002386812.1 CDS ydaL NC_011741.1 1427258 1427821 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1427258..1427821 Escherichia coli IAI1 7126087 YP_002386813.1 CDS ydaM NC_011741.1 1427842 1429074 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16045609; Product type pe : putative enzyme; putative diguanylate cyclase complement(1427842..1429074) Escherichia coli IAI1 7127849 YP_002386814.1 CDS zntB NC_011741.1 1429329 1430312 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; zinc transporter 1429329..1430312 Escherichia coli IAI1 7127850 YP_002386815.1 CDS ECIAI1_1372 NC_011741.1 1430587 1430760 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1430587..1430760 Escherichia coli IAI1 7127851 YP_002386816.1 CDS dbpA NC_011741.1 1430790 1432163 D exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA 1430790..1432163 Escherichia coli IAI1 7124433 YP_002386817.1 CDS ydaO NC_011741.1 1432292 1433227 R TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase complement(1432292..1433227) Escherichia coli IAI1 7126921 YP_002386818.1 CDS uspF NC_011741.1 1433403 1433837 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 12381839, 11849540, 9298646; Product type f : factor; stress-induced protein, ATP-binding protein complement(1433403..1433837) Escherichia coli IAI1 7127852 YP_002386819.1 CDS ompN NC_011741.1 1433978 1435111 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9642192; Product type t : transporter; outer membrane pore protein N, non-specific complement(1433978..1435111) Escherichia coli IAI1 7125552 YP_002386820.1 CDS ydbK NC_011741.1 1435478 1439002 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9025293; Product type pe : putative enzyme; putative 2-oxoacid-flavodoxin fused oxidoreductase:conserved protein; 4Fe-4S cluster binding protein complement(1435478..1439002) Escherichia coli IAI1 7124273 YP_002386821.1 CDS ydbJ NC_011741.1 1439276 1439542 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1439276..1439542 Escherichia coli IAI1 7127370 YP_002386822.1 CDS hslJ NC_011741.1 1439539 1439961 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12892888, 8349564, 9025293; Product type f : factor; heat-inducible protein complement(1439539..1439961) Escherichia coli IAI1 7127288 YP_002386823.1 CDS ldhA NC_011741.1 1440072 1441061 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4297266, 89123040, 90198524, 8349564, 9025293; Product type e : enzyme; fermentative D-lactate dehydrogenase complement(1440072..1441061) Escherichia coli IAI1 7125312 YP_002386824.1 CDS ydbH NC_011741.1 1441269 1443908 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1441269..1443908 Escherichia coli IAI1 7126399 YP_002386825.1 CDS ynbE NC_011741.1 1443905 1444090 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 1443905..1444090 Escherichia coli IAI1 7127855 YP_002386826.1 CDS ydbL NC_011741.1 1444098 1444424 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1444098..1444424 Escherichia coli IAI1 7127541 YP_002386827.1 CDS feaR NC_011741.1 1444596 1445501 R activator of genes involved in phenylacetic acid catabolism; DNA-binding transcriptional activator FeaR complement(1444596..1445501) Escherichia coli IAI1 7127371 YP_002386828.1 CDS feaB NC_011741.1 1445737 1447236 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96213037, 97263463, 9043126; Product type e : enzyme; phenylacetaldehyde dehydrogenase 1445737..1447236 Escherichia coli IAI1 7127084 YP_002386829.1 CDS tynA NC_011741.1 1447294 1449567 R catalyzes the formation of phenylacetaldehyde from 2-phenylethylamine; tyramine oxidase complement(1447294..1449567) Escherichia coli IAI1 7127083 YP_002386830.1 CDS maoC NC_011741.1 1449815 1451860 R catalyzes the ring cleavage reaction in phenylacetate degradation and the formation of 3-hydroxyacyl-CoA from crotonyl-CoA; bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase complement(1449815..1451860) Escherichia coli IAI1 7127524 YP_002386831.1 CDS paaA NC_011741.1 1452145 1453074 D with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; phenylacetate-CoA oxygenase subunit PaaA 1452145..1453074 Escherichia coli IAI1 7127671 YP_002386832.1 CDS paaB NC_011741.1 1453086 1453373 D with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; involved in phenylacetate degradation; phenylacetate-CoA oxygenase subunit PaaB 1453086..1453373 Escherichia coli IAI1 7126004 YP_002386833.1 CDS paaC NC_011741.1 1453382 1454128 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12846838, 9748275; Product type pe : putative enzyme; putative multicomponent oxygenase/reductase subunit for phenylacetic acid degradation 1453382..1454128 Escherichia coli IAI1 7126005 YP_002386834.1 CDS paaD NC_011741.1 1454143 1454640 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12846838, 9748275; Product type pe : putative enzyme; putative multicomponent oxygenase/reductase subunit for phenylacetic acid degradation 1454143..1454640 Escherichia coli IAI1 7126006 YP_002386835.1 CDS paaJ NC_011741.1 1454648 1455718 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17259607, 11260461, 12846838, 9748275; Product type e : enzyme; subunit of the phenylacetly-CoA oxygenase/reductase 1454648..1455718 Escherichia coli IAI1 7126007 YP_002386836.1 CDS paaF NC_011741.1 1455715 1456482 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12846838, 9748275, 10766858; Product type e : enzyme; enoyl-CoA hydratase-isomerase 1455715..1456482 Escherichia coli IAI1 7126013 YP_002386837.1 CDS paaG NC_011741.1 1456482 1457270 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1456482..1457270 Escherichia coli IAI1 7126009 YP_002386838.1 CDS paaH NC_011741.1 1457272 1458699 D converts 3-hydroxyadipyl-CoA to beta-ketoadipyl-CoA in phenylacetate degradation; 3-hydroxy-acyl-CoA dehydrogenase 1457272..1458699 Escherichia coli IAI1 7126010 YP_002386839.1 CDS paaI NC_011741.1 1458689 1459111 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16464851, 12846838, 9748275; Product type e : enzyme; phenylacetate pathway hotdog-fold thioesterase 1458689..1459111 Escherichia coli IAI1 7126011 YP_002386840.1 CDS paaE NC_011741.1 1459111 1460316 D catalyzes the thiolytic cleavage of beta-ketoadipyl-CoA to succinate and acetyl-CoA; beta-ketoadipyl CoA thiolase 1459111..1460316 Escherichia coli IAI1 7126012 YP_002386841.1 CDS paaK NC_011741.1 1460343 1461656 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12846838, 9748275, 10766858; Product type e : enzyme; phenylacetyl-CoA ligase 1460343..1461656 Escherichia coli IAI1 7126008 YP_002386842.1 CDS paaX NC_011741.1 1461757 1462707 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12846838, 20229831, 9748275; Product type r : regulator; DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive 1461757..1462707 Escherichia coli IAI1 7126014 YP_002386843.1 CDS paaY NC_011741.1 1462689 1463279 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12846838, 9748275; Product type pe : putative enzyme; putative hexapeptide repeat acetyltransferase 1462689..1463279 Escherichia coli IAI1 7126015 YP_002386844.1 CDS ydbC NC_011741.1 1463511 1464371 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1463511..1464371 Escherichia coli IAI1 7126016 YP_002386845.1 CDS ydbD NC_011741.1 1464435 1466741 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1464435..1466741 Escherichia coli IAI1 7127853 YP_002386846.1 CDS ynbA NC_011741.1 1466912 1467517 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1466912..1467517 Escherichia coli IAI1 7127854 YP_002386847.1 CDS ynbB NC_011741.1 1467517 1468413 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane associated CTP-phosphosubstrate transferase 1467517..1468413 Escherichia coli IAI1 7127537 YP_002386848.1 CDS ynbC NC_011741.1 1468429 1470186 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 1468429..1470186 Escherichia coli IAI1 7127538 YP_002386849.1 CDS ynbD NC_011741.1 1470200 1471492 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane associated phosphatase 1470200..1471492 Escherichia coli IAI1 7127539 YP_002386850.1 CDS azoR NC_011741.1 1471543 1472148 R FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase complement(1471543..1472148) Escherichia coli IAI1 7127540 YP_002386851.1 CDS hrpA NC_011741.1 1472406 1476251 D involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1472406..1476251 Escherichia coli IAI1 7126284 YP_002386852.1 CDS ydcF NC_011741.1 1476523 1477323 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1476523..1477323 Escherichia coli IAI1 7125307 YP_002386853.1 CDS aldA NC_011741.1 1477520 1478959 D NAD-linked; aldehyde dehydrogenase A 1477520..1478959 Escherichia coli IAI1 7127374 YP_002386854.1 CDS gapC NC_011741.1 1479001 1480002 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9622357, 9019141, 1917845, 3780374; Product type e : enzyme; glyceraldehyde-3-phosphate dehydrogenase C complement(1479001..1480002) Escherichia coli IAI1 7125741 YP_002386855.1 CDS cybB NC_011741.1 1480191 1480721 D B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 1480191..1480721 Escherichia coli IAI1 7128278 YP_002386856.1 CDS ydcA NC_011741.1 1480966 1481139 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1480966..1481139 Escherichia coli IAI1 7124652 YP_002386857.1 CDS mokB NC_011741.1 1481251 1481418 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type r : regulator; regulatory peptide complement(1481251..1481418) Escherichia coli IAI1 7127372 YP_002386858.1 CDS trg NC_011741.1 1481759 1483399 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90008892, 92390356, 93259131, 6374654; Product type r : regulator; methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor 1481759..1483399 Escherichia coli IAI1 7127946 YP_002386859.1 CDS ydcI NC_011741.1 1483437 1484360 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1483437..1484360) Escherichia coli IAI1 7127484 YP_002386860.1 CDS ydcJ NC_011741.1 1484577 1485920 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1484577..1485920 Escherichia coli IAI1 7127376 YP_002386861.1 CDS mdoD NC_011741.1 1486175 1487800 D involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 1486175..1487800 Escherichia coli IAI1 7127377 YP_002386862.1 CDS ECIAI1_1420 NC_011741.1 1487721 1487924 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1487721..1487924) Escherichia coli IAI1 7127685 YP_002386863.1 CDS ydcH NC_011741.1 1487940 1488164 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1487940..1488164 Escherichia coli IAI1 7128661 YP_002386864.1 CDS rimL NC_011741.1 1488212 1488763 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89364711; Product type e : enzyme; ribosomal-protein-L7/L12-serine acetyltransferase 1488212..1488763 Escherichia coli IAI1 7127375 YP_002386865.1 CDS ydcK NC_011741.1 1488758 1489738 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(1488758..1489738) Escherichia coli IAI1 7125004 YP_002386866.1 CDS tehA NC_011741.1 1489862 1490854 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94222856, 2060788; Product type t : transporter; potassium-tellurite ethidium and proflavin transporter 1489862..1490854 Escherichia coli IAI1 7127378 YP_002386867.1 CDS tehB NC_011741.1 1490851 1491444 D with TehA confers resistance to tellurite; tellurite resistance protein TehB 1490851..1491444 Escherichia coli IAI1 7126234 YP_002386868.1 CDS ydcL NC_011741.1 1491747 1492415 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 1491747..1492415 Escherichia coli IAI1 7126235 YP_002386869.1 CDS ECIAI1_1427 NC_011741.1 1492433 1492600 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; putative transposase ORF A (fragment), IS605 family complement(1492433..1492600) Escherichia coli IAI1 7127379 YP_002386870.1 CDS yncK NC_011741.1 1492652 1492939 R Evidence 7 : Gene remnant; hypothetical protein complement(1492652..1492939) Escherichia coli IAI1 7128662 YP_002386871.1 CDS ydcM NC_011741.1 1492947 1494155 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase 1492947..1494155 Escherichia coli IAI1 7127550 YP_002386872.1 CDS ydcO NC_011741.1 1494195 1495370 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1885518; Product type pt : putative transporter; putative benzoate transporter complement(1494195..1495370) Escherichia coli IAI1 7127380 YP_002386873.1 CDS ydcN NC_011741.1 1495462 1495998 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1495462..1495998 Escherichia coli IAI1 7127384 YP_002386874.1 CDS ydcP NC_011741.1 1496071 1498032 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 1496071..1498032 Escherichia coli IAI1 7127383 YP_002386875.1 CDS yncJ NC_011741.1 1498124 1498354 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1498124..1498354) Escherichia coli IAI1 7127385 YP_002386876.1 CDS ydcQ NC_011741.1 1498755 1499192 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1498755..1499192 Escherichia coli IAI1 7127549 YP_002386877.1 CDS ydcR NC_011741.1 1499271 1500677 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15223311; Product type pr : putative regulator; putative DNA-binding transcriptional regulator fused with a domain with PLP-binding motif 1499271..1500677 Escherichia coli IAI1 7127386 YP_002386878.1 CDS ydcS NC_011741.1 1500922 1502067 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11683869; Product type pt : putative transporter; putative spermidine/putrescine ABC transporter periplasmic-binding protein 1500922..1502067 Escherichia coli IAI1 7127387 YP_002386879.1 CDS ydcT NC_011741.1 1502085 1503098 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative spermidine/putrescine ABC transporter ATP-binding protein 1502085..1503098 Escherichia coli IAI1 7127388 YP_002386880.1 CDS ydcU NC_011741.1 1503099 1504040 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative spermidine/putrescine ABC transporter permease 1503099..1504040 Escherichia coli IAI1 7127389 YP_002386881.1 CDS ydcV NC_011741.1 1504030 1504824 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative spermidine/putrescine ABC transporter permease 1504030..1504824 Escherichia coli IAI1 7127390 YP_002386882.1 CDS ydcW NC_011741.1 1504846 1506270 D catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 1504846..1506270 Escherichia coli IAI1 7127391 YP_002386883.1 CDS ECIAI1_1441 NC_011741.1 1506480 1507289 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8257133, 11841212, 12771141; Product type pe : putative enzyme; putative acetyltransferase 1506480..1507289 Escherichia coli IAI1 7127392 YP_002386884.1 CDS ydcX NC_011741.1 1507906 1508154 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1507906..1508154 Escherichia coli IAI1 7128663 YP_002386885.1 CDS ydcY NC_011741.1 1508240 1508473 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1508240..1508473 Escherichia coli IAI1 7127393 YP_002386886.1 CDS ydcZ NC_011741.1 1508474 1508923 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1508474..1508923) Escherichia coli IAI1 7127394 YP_002386887.1 CDS yncA NC_011741.1 1508920 1509672 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA N-acyltransferase complement(1508920..1509672) Escherichia coli IAI1 7127395 YP_002386888.1 CDS yncB NC_011741.1 1509619 1510656 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative conserved oxidoreductase 1509619..1510656 Escherichia coli IAI1 7127542 YP_002386889.1 CDS yncC NC_011741.1 1510854 1511519 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11004173; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1510854..1511519 Escherichia coli IAI1 7127543 YP_002386890.1 CDS yncD NC_011741.1 1511555 1513657 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative iron outer membrane receptor complement(1511555..1513657) Escherichia coli IAI1 7127544 YP_002386891.1 CDS yncE NC_011741.1 1513899 1514960 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1513899..1514960 Escherichia coli IAI1 7127545 YP_002386892.1 CDS ansP NC_011741.1 1515075 1516574 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76005443; Product type t : transporter; L-asparagine transporter complement(1515075..1516574) Escherichia coli IAI1 7127546 YP_002386893.1 CDS yncG NC_011741.1 1516841 1517458 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; glutathione S-transferase-like protein 1516841..1517458 Escherichia coli IAI1 7125766 YP_002386894.1 CDS rhsD NC_011741.1 1520742 1524950 D Evidence 2b : Function of strongly homologous gene; PubMedId : 98361897, 1766878, 2403547, 2644231, 7934896; Product type h : extrachromosomal origin; rhsD element protein 1520742..1524950 Escherichia coli IAI1 7125569 YP_002386895.1 CDS ECIAI1_1456 NC_011741.1 1524926 1525357 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9696756; hypothetical protein 1524926..1525357 Escherichia coli IAI1 7124988 YP_002386896.1 CDS ECIAI1_1457 NC_011741.1 1525424 1525573 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1525424..1525573 Escherichia coli IAI1 7128664 YP_002386897.1 CDS ECIAI1_1459 NC_011741.1 1526776 1527255 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1526776..1527255 Escherichia coli IAI1 7127146 YP_002386898.1 CDS ECIAI1_1460 NC_011741.1 1527521 1527715 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1527521..1527715 Escherichia coli IAI1 7128666 YP_002386899.1 CDS ECIAI1_1461 NC_011741.1 1527790 1532058 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1766878, 2644231, 2403547, 7934896; putative protein rhsD 1527790..1532058 Escherichia coli IAI1 7128667 YP_002386900.1 CDS ECIAI1_1462 NC_011741.1 1532058 1532519 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9696756; hypothetical protein 1532058..1532519 Escherichia coli IAI1 7128668 YP_002386901.1 CDS ECIAI1_1464 NC_011741.1 1533538 1533831 D 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 1533538..1533831 Escherichia coli IAI1 7127147 YP_002386902.1 CDS yddH NC_011741.1 1533835 1534404 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1533835..1534404) Escherichia coli IAI1 7128670 YP_002386903.1 CDS nhoA NC_011741.1 1534577 1535422 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20267568; Product type e : enzyme; N-hydroxyarylamine O-acetyltransferase 1534577..1535422 Escherichia coli IAI1 7127400 YP_002386904.1 CDS yddE NC_011741.1 1535518 1536411 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14611652, 15103639, 2233673; hypothetical protein complement(1535518..1536411) Escherichia coli IAI1 7127876 YP_002386905.1 CDS narV NC_011741.1 1536491 1537171 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type e : enzyme; nitrate reductase 2 subunit gamma complement(1536491..1537171) Escherichia coli IAI1 7127398 YP_002386906.1 CDS narW NC_011741.1 1537168 1537863 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410, 92186712; Product type f : factor; nitrate reductase 2 subunit delta (assembly subunit) complement(1537168..1537863) Escherichia coli IAI1 7127858 YP_002386907.1 CDS narY NC_011741.1 1537863 1539407 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type c : carrier; nitrate reductase 2 subunit beta complement(1537863..1539407) Escherichia coli IAI1 7127859 YP_002386908.1 CDS narZ NC_011741.1 1539404 1543144 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type e : enzyme; nitrate reductase 2 subunit alpha complement(1539404..1543144) Escherichia coli IAI1 7127861 YP_002386909.1 CDS narU NC_011741.1 1543226 1544614 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95266795, 2233673; Product type t : transporter; nitrate/nitrite transporter complement(1543226..1544614) Escherichia coli IAI1 7127862 YP_002386910.1 CDS ECIAI1_1474 NC_011741.1 1544938 1546269 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1544938..1546269) Escherichia coli IAI1 7127857 YP_002386911.1 CDS yddL NC_011741.1 1546293 1546583 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7926834; Product type m : membrane component; outer membrane porin complement(1546293..1546583) Escherichia coli IAI1 7128671 YP_002386912.1 CDS yddG NC_011741.1 1546842 1547666 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12410826; Product type t : transporter; hypothetical protein complement(1546842..1547666) Escherichia coli IAI1 7127401 YP_002386913.1 CDS fdnG NC_011741.1 1547955 1551002 D Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-N subunit alpha 1547955..1551002 Escherichia coli IAI1 7127399 YP_002386914.1 CDS fdnH NC_011741.1 1551015 1551899 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76005553, 90375017, 92332427, 11884747, 1834669; Product type c : carrier; formate dehydrogenase-N, Fe-S subunit beta 1551015..1551899 Escherichia coli IAI1 7127075 YP_002386915.1 CDS fdnI NC_011741.1 1551892 1552545 D nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma 1551892..1552545 Escherichia coli IAI1 7127076 YP_002386916.1 CDS yddM NC_011741.1 1552596 1552958 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1552596..1552958) Escherichia coli IAI1 7127077 YP_002386917.1 CDS adhP NC_011741.1 1553027 1554037 R similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase complement(1553027..1554037) Escherichia coli IAI1 7127402 YP_002386918.1 CDS sfcA NC_011741.1 1554171 1555868 R malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase complement(1554171..1555868) Escherichia coli IAI1 7125718 YP_002386919.1 CDS bdm NC_011741.1 1556264 1556479 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10498711, 13129944; Product type f : factor; biofilm-dependent modulation protein complement(1556264..1556479) Escherichia coli IAI1 7127915 YP_002386920.1 CDS osmC NC_011741.1 1556824 1557255 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14512736, 91350191, 9298646; Product type m : membrane component; osmotically inducible, stress-inducible membrane protein 1556824..1557255 Escherichia coli IAI1 7124393 YP_002386921.1 CDS ECIAI1_1486 NC_011741.1 1557290 1558060 R catalyzes the formation of acetoacetate from 3-hydroxybutyrate; 3-hydroxybutyrate dehydrogenase complement(1557290..1558060) Escherichia coli IAI1 7125996 YP_002386922.1 CDS ECIAI1_1487 NC_011741.1 1558072 1559463 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1558072..1559463) Escherichia coli IAI1 7128672 YP_002386923.1 CDS ECIAI1_1488 NC_011741.1 1559509 1560432 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 3-hydroxyacyl-CoA dehydrogenase complement(1559509..1560432) Escherichia coli IAI1 7128673 YP_002386924.1 CDS ECIAI1_1489 NC_011741.1 1560422 1561627 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyl-CoA acetyltransferase complement(1560422..1561627) Escherichia coli IAI1 7128674 YP_002386925.1 CDS scoB NC_011741.1 1561637 1562293 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9385134; Product type e : enzyme; succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B complement(1561637..1562293) Escherichia coli IAI1 7128675 YP_002386926.1 CDS scoA NC_011741.1 1562296 1563003 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9385134; Product type e : enzyme; succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A complement(1562296..1563003) Escherichia coli IAI1 7124682 YP_002386927.1 CDS ECIAI1_1492 NC_011741.1 1563145 1564035 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type r : regulator; putative transcriptional regulator 1563145..1564035 Escherichia coli IAI1 7124681 YP_002386928.1 CDS ddpF NC_011741.1 1564072 1564998 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-ala ABC transporter ATP-binding protein complement(1564072..1564998) Escherichia coli IAI1 7128676 YP_002386929.1 CDS ddpD NC_011741.1 1564991 1565977 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-ala ABC transporter ATP-binding protein complement(1564991..1565977) Escherichia coli IAI1 7124554 YP_002386930.1 CDS ddpC NC_011741.1 1565974 1566870 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; ATP-dependent peptide transporter membrane subunit complement(1565974..1566870) Escherichia coli IAI1 7124553 YP_002386931.1 CDS ddpB NC_011741.1 1566867 1567889 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-ala ABC transporter membrane protein complement(1566867..1567889) Escherichia coli IAI1 7124552 YP_002386932.1 CDS ddpA NC_011741.1 1567891 1569441 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-a la ABC transporter periplasmic-binding protein complement(1567891..1569441) Escherichia coli IAI1 7124551 YP_002386933.1 CDS ddpX NC_011741.1 1569455 1570036 R catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis; D-alanyl-D-alanine dipeptidase complement(1569455..1570036) Escherichia coli IAI1 7124550 YP_002386934.1 CDS dos NC_011741.1 1570294 1572693 R heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate; cAMP phosphodiesterase complement(1570294..1572693) Escherichia coli IAI1 7124555 YP_002386935.1 CDS yddV NC_011741.1 1572718 1574100 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16497924, 15142243; Product type pe : putative enzyme; putative diguanylate cyclase complement(1572718..1574100) Escherichia coli IAI1 7124615 YP_002386936.1 CDS yddW NC_011741.1 1574472 1575791 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10960106; Product type lp : lipoprotein; hypothetical protein complement(1574472..1575791) Escherichia coli IAI1 7127403 YP_002386937.1 CDS gadC NC_011741.1 1575922 1577457 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15795232, 15489450; Product type t : transporter; glutamate:gamma-aminobutyric acid antiporter complement(1575922..1577457) Escherichia coli IAI1 7127404 YP_002386938.1 CDS gadB NC_011741.1 1577613 1579013 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12912902, 92155241, 92394884, 99406302, 8455549; Product type e : enzyme; glutamate decarboxylase B, PLP-dependent complement(1577613..1579013) Escherichia coli IAI1 7128263 YP_002386939.1 CDS pqqL NC_011741.1 1579375 1582170 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1659611, 11514505; Product type pe : putative enzyme; putative membrane-associated peptidase complement(1579375..1582170) Escherichia coli IAI1 7128262 YP_002386940.1 CDS yddB NC_011741.1 1582215 1584587 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative porin protein complement(1582215..1584587) Escherichia coli IAI1 7126142 YP_002386941.1 CDS yddA NC_011741.1 1584625 1586310 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative multidrug transporter fused subunits of ABC superfamily transporter: permease; ATP-binding component complement(1584625..1586310) Escherichia coli IAI1 7127397 YP_002386942.1 CDS ydeM NC_011741.1 1586601 1587758 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pr : putative regulator; hypothetical protein complement(1586601..1587758) Escherichia coli IAI1 7127396 YP_002386943.1 CDS ydeN NC_011741.1 1587810 1589492 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sulfatase complement(1587810..1589492) Escherichia coli IAI1 7127410 YP_002386944.1 CDS ydeO NC_011741.1 1589894 1590655 R regulates the cellular response to acid resistance; transcriptional regulator YdeO complement(1589894..1590655) Escherichia coli IAI1 7127411 YP_002386945.1 CDS ECIAI1_1510 NC_011741.1 1590730 1590927 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1590730..1590927) Escherichia coli IAI1 7127412 YP_002386946.1 CDS ydeP NC_011741.1 1591175 1593454 R in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase family; putative oxidoreductase complement(1591175..1593454) Escherichia coli IAI1 7128677 YP_002386947.1 CDS ydeQ NC_011741.1 1593788 1594702 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like exported adhesin protein complement(1593788..1594702) Escherichia coli IAI1 7127413 YP_002386948.1 CDS ydeR NC_011741.1 1594762 1595265 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein complement(1594762..1595265) Escherichia coli IAI1 7127414 YP_002386949.1 CDS ydeS NC_011741.1 1595278 1595808 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein complement(1595278..1595808) Escherichia coli IAI1 7127415 YP_002386950.1 CDS ECIAI1_1515 NC_011741.1 1595822 1598473 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative fimbrial outer membrane usher protein complement(1595822..1598473) Escherichia coli IAI1 7127416 YP_002386951.1 CDS ECIAI1_1516 NC_011741.1 1598515 1599234 R Evidence 2b : Function of strongly homologous gene; Product type f : factor; Periplasmic chaperone complement(1598515..1599234) Escherichia coli IAI1 7128678 YP_002386952.1 CDS ECIAI1_1517 NC_011741.1 1599445 1599591 D hypothetical protein 1599445..1599591 Escherichia coli IAI1 7128679 YP_002386953.1 CDS ECIAI1_1518 NC_011741.1 1599586 1600197 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative major fimbrial subunit FmlA complement(1599586..1600197) Escherichia coli IAI1 7128680 YP_002386954.1 CDS yneL NC_011741.1 1600606 1600785 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator complement(1600606..1600785) Escherichia coli IAI1 7128681 YP_002386955.1 CDS hipA NC_011741.1 1601102 1602424 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358364, 94292428, 15576765; Product type r : regulator; regulator with hipB complement(1601102..1602424) Escherichia coli IAI1 7127560 YP_002386956.1 CDS hipB NC_011741.1 1602424 1602690 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358364, 94292428, 15576765, 8021189; Product type r : regulator; DNA-binding transcriptional regulator HipB complement(1602424..1602690) Escherichia coli IAI1 7128526 YP_002386957.1 CDS ECIAI1_1522 NC_011741.1 1602899 1608319 R Evidence 4 : Homologs of previously reported genes of unknown function; putative lipoprotein/autotransporter domain-containing protein complement(1602899..1608319) Escherichia coli IAI1 7125188 YP_002386958.1 CDS lsrK NC_011741.1 1608850 1610442 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15601708, 14622426; Product type e : enzyme; autoinducer-2 (AI-2) kinase complement(1608850..1610442) Escherichia coli IAI1 7128682 YP_002386959.1 CDS lsrR NC_011741.1 1610521 1611474 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16321939, 15601708, 14622426; Product type r : regulator; DNA-binding transcriptional regulator complement(1610521..1611474) Escherichia coli IAI1 7127638 YP_002386960.1 CDS ego NC_011741.1 1611723 1613258 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12657059, 11722742; Product type t : transporter; AI2 ABC transporter ATP-binding protein 1611723..1613258 Escherichia coli IAI1 7127639 YP_002386961.1 CDS lsrC NC_011741.1 1613252 1614280 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11722742; Product type t : transporter; AI2 ABC transporter membrane protein 1613252..1614280 Escherichia coli IAI1 7125054 YP_002386962.1 CDS lsrD NC_011741.1 1614280 1615272 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11722742; Product type t : transporter; AI2 ABC transporter membrane protein 1614280..1615272 Escherichia coli IAI1 7127634 YP_002386963.1 CDS lsrB NC_011741.1 1615284 1616306 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11722742; Product type t : transporter; AI2 ABC transporter periplasmic-binding protein 1615284..1616306 Escherichia coli IAI1 7127635 YP_002386964.1 CDS lsrF NC_011741.1 1616333 1617208 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; aldolase 1616333..1617208 Escherichia coli IAI1 7127633 YP_002386965.1 CDS lsrG NC_011741.1 1617232 1617522 D Evidence 4 : Homologs of previously reported genes of unknown function; autoinducer-2 (AI-2) modifying protein LsrG 1617232..1617522 Escherichia coli IAI1 7127636 YP_002386966.1 CDS tam NC_011741.1 1617579 1618337 D catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 1617579..1618337 Escherichia coli IAI1 7127637 YP_002386967.1 CDS yneE NC_011741.1 1618341 1619255 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1618341..1619255) Escherichia coli IAI1 7126210 YP_002386968.1 CDS uxaB NC_011741.1 1619462 1620913 R catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase complement(1619462..1620913) Escherichia coli IAI1 7127552 YP_002386969.1 CDS yneF NC_011741.1 1621140 1622558 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated diguanylate cyclase complement(1621140..1622558) Escherichia coli IAI1 7125561 YP_002386970.1 CDS yneG NC_011741.1 1622697 1623056 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1622697..1623056) Escherichia coli IAI1 7127553 YP_002386971.1 CDS yneH NC_011741.1 1623056 1623982 R catalyzes the formation of glutamate from glutamine; glutaminase complement(1623056..1623982) Escherichia coli IAI1 7127554 YP_002386972.1 CDS yneI NC_011741.1 1624046 1625434 R in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; putative succinate semialdehyde dehydrogenase complement(1624046..1625434) Escherichia coli IAI1 7127555 YP_002386973.1 CDS yneJ NC_011741.1 1625535 1626416 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1625535..1626416 Escherichia coli IAI1 7127556 YP_002386974.1 CDS ydeA NC_011741.1 1627758 1628948 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10094697, 99369894, 8383113, 10438792; Product type t : transporter; sugar efflux transporter 1627758..1628948 Escherichia coli IAI1 7127559 YP_002386975.1 CDS marC NC_011741.1 1628973 1629638 R protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC complement(1628973..1629638) Escherichia coli IAI1 7127405 YP_002386976.1 CDS marR NC_011741.1 1629850 1630284 D Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; DNA-binding transcriptional repressor MarR 1629850..1630284 Escherichia coli IAI1 7127675 YP_002386977.1 CDS marA NC_011741.1 1630304 1630687 D transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; DNA-binding transcriptional activator MarA 1630304..1630687 Escherichia coli IAI1 7127676 YP_002386978.1 CDS marB NC_011741.1 1630719 1630937 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8383113; hypothetical protein 1630719..1630937 Escherichia coli IAI1 7127673 YP_002386979.1 CDS celA NC_011741.1 1630994 1632439 R converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase complement(1630994..1632439) Escherichia coli IAI1 7127674 YP_002386980.1 CDS ECIAI1_1547 NC_011741.1 1632458 1634131 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative carbohydrate-specific outer membrane porin complement(1632458..1634131) Escherichia coli IAI1 7128683 YP_002386981.1 CDS ECIAI1_1548 NC_011741.1 1634187 1634501 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system PTS, lactose/cellobiose-specific IIA subunit complement(1634187..1634501) Escherichia coli IAI1 7128684 YP_002386982.1 CDS ECIAI1_1549 NC_011741.1 1634526 1635887 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system IIC component complement(1634526..1635887) Escherichia coli IAI1 7128685 YP_002386983.1 CDS ECIAI1_1550 NC_011741.1 1635963 1636274 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cellobiose-specific phosphotransferase enzyme IIB component complement(1635963..1636274) Escherichia coli IAI1 7128686 YP_002386984.1 CDS ECIAI1_1551 NC_011741.1 1636473 1637171 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator HTH family 1636473..1637171 Escherichia coli IAI1 7128687 YP_002386985.1 CDS eamA NC_011741.1 1637216 1638115 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20305052; Product type t : transporter; O-acetylserine/cysteine export protein complement(1637216..1638115) Escherichia coli IAI1 7128688 YP_002386986.1 CDS ydeE NC_011741.1 1638310 1639497 D YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters; putative MFS-type transporter YdeE 1638310..1639497 Escherichia coli IAI1 7125039 YP_002386987.1 CDS ydeH NC_011741.1 1639938 1640828 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1639938..1640828) Escherichia coli IAI1 7127406 YP_002386988.1 CDS ydeI NC_011741.1 1641083 1641475 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1641083..1641475) Escherichia coli IAI1 7127407 YP_002386989.1 CDS ydeJ NC_011741.1 1641751 1642269 D Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A 1641751..1642269 Escherichia coli IAI1 7127408 YP_002386990.1 CDS dcp NC_011741.1 1642314 1644359 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 216006, 8226676; Product type e : enzyme; dipeptidyl carboxypeptidase II complement(1642314..1644359) Escherichia coli IAI1 7127409 YP_002386991.1 CDS ydfG NC_011741.1 1644496 1645242 D NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase 1644496..1645242 Escherichia coli IAI1 7126924 YP_002386992.1 CDS ydfH NC_011741.1 1645331 1646017 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1645331..1646017 Escherichia coli IAI1 7127421 YP_002386993.1 CDS ydfZ NC_011741.1 1646195 1646398 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12084818; Product type pc : putative carrier; putative selenium carrying protein 1646195..1646398 Escherichia coli IAI1 7127422 YP_002386994.1 CDS ydfI NC_011741.1 1646434 1647894 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative mannonate dehydrogenase complement(1646434..1647894) Escherichia coli IAI1 7127432 YP_002386995.1 CDS ydfJ NC_011741.1 1647983 1649266 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(1647983..1649266) Escherichia coli IAI1 7127423 YP_002386996.1 CDS ydfK NC_011741.1 1650019 1650285 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1650019..1650285 Escherichia coli IAI1 7127424 YP_002386997.1 CDS pinR NC_011741.1 1650602 1651192 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14687564; Product type pe : putative enzyme; putative site-specific recombinase; DNA invertase; Rac prophage 1650602..1651192 Escherichia coli IAI1 7127425 YP_002386998.1 CDS tfaQ NC_011741.1 1651290 1651865 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative tail fiber chaperone; Qin prophage complement(1651290..1651865) Escherichia coli IAI1 7124225 YP_002386999.1 CDS ECIAI1_1566 NC_011741.1 1651865 1654831 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber protein complement(1651865..1654831) Escherichia coli IAI1 7126238 YP_002387000.1 CDS ECIAI1_1567 NC_011741.1 1653324 1654328 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1653324..1654328 Escherichia coli IAI1 7128689 YP_002387001.1 CDS ECIAI1_1568 NC_011741.1 1654716 1654889 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1654716..1654889 Escherichia coli IAI1 7128690 YP_002387002.1 CDS ECIAI1_1569 NC_011741.1 1654890 1655489 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Lom-like outer membrane protein of phage origin complement(1654890..1655489) Escherichia coli IAI1 7128691 YP_002387003.1 CDS ECIAI1_1570 NC_011741.1 1655560 1659057 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J of prophage complement(1655560..1659057) Escherichia coli IAI1 7128692 YP_002387004.1 CDS ECIAI1_1571 NC_011741.1 1659118 1659789 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Tail assembly protein I complement(1659118..1659789) Escherichia coli IAI1 7128693 YP_002387005.1 CDS ECIAI1_1572 NC_011741.1 1659687 1660430 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber component K of prophage complement(1659687..1660430) Escherichia coli IAI1 7128694 YP_002387006.1 CDS ECIAI1_1574 NC_011741.1 1661135 1661464 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein M complement(1661135..1661464) Escherichia coli IAI1 7128696 YP_002387007.1 CDS ECIAI1_1575 NC_011741.1 1661461 1664040 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein H complement(1661461..1664040) Escherichia coli IAI1 7128697 YP_002387008.1 CDS ECIAI1_1576 NC_011741.1 1664033 1664467 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein T complement(1664033..1664467) Escherichia coli IAI1 7128698 YP_002387009.1 CDS ECIAI1_1577 NC_011741.1 1664449 1664871 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein G complement(1664449..1664871) Escherichia coli IAI1 7128699 YP_002387010.1 CDS ECIAI1_1578 NC_011741.1 1664887 1665657 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major tail protein V complement(1664887..1665657) Escherichia coli IAI1 7128700 YP_002387011.1 CDS ECIAI1_1579 NC_011741.1 1665635 1666030 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein U complement(1665635..1666030) Escherichia coli IAI1 7128701 YP_002387012.1 CDS ECIAI1_1580 NC_011741.1 1666027 1666605 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein Z (GpZ) complement(1666027..1666605) Escherichia coli IAI1 7125590 YP_002387013.1 CDS fII NC_011741.1 1666617 1666970 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin; Tail attachment protein (Minor capsid protein FII) from bacteriophage origin complement(1666617..1666970) Escherichia coli IAI1 7126769 YP_002387014.1 CDS fI NC_011741.1 1666982 1667416 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; DNA packaging protein from bacteriophage origin complement(1666982..1667416) Escherichia coli IAI1 7127109 YP_002387015.1 CDS E NC_011741.1 1667419 1668471 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Major head coat protein from bacteriophage origin complement(1667419..1668471) Escherichia coli IAI1 7127105 YP_002387016.1 CDS D NC_011741.1 1668500 1668838 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Head decoration protein from bacteriophage origin complement(1668500..1668838) Escherichia coli IAI1 7125038 YP_002387017.1 CDS C NC_011741.1 1668842 1670296 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin; Minor capsid protein C from bacteriophage origin complement(1668842..1670296) Escherichia coli IAI1 7126907 YP_002387018.1 CDS B NC_011741.1 1670142 1671743 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Portal protein; minor capsid protein complement(1670142..1671743) Escherichia coli IAI1 7124430 YP_002387019.1 CDS W NC_011741.1 1671740 1671946 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11302702; Product type h : extrachromosomal origin; Head-to-tail joining protein W (gpW) from bacteriophage origin complement(1671740..1671946) Escherichia coli IAI1 7126286 YP_002387020.1 CDS A NC_011741.1 1671943 1673868 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Terminase large subunit from bacteriophage origin complement(1671943..1673868) Escherichia coli IAI1 7125573 YP_002387021.1 CDS nohB NC_011741.1 1673843 1674388 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92334985; Product type h : extrachromosomal origin; DNA packaging protein; DLP12 prophage complement(1673843..1674388) Escherichia coli IAI1 7125674 YP_002387022.1 CDS ECIAI1_1590 NC_011741.1 1674528 1674671 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1674528..1674671) Escherichia coli IAI1 7127895 YP_002387023.1 CDS ynfO NC_011741.1 1674777 1675010 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1674777..1675010 Escherichia coli IAI1 7126770 YP_002387024.1 CDS ydfO NC_011741.1 1675068 1675478 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1675068..1675478 Escherichia coli IAI1 7127573 YP_002387025.1 CDS gnsB NC_011741.1 1675630 1675803 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21429224; Product type h : extrachromosomal origin; hypothetical protein complement(1675630..1675803) Escherichia coli IAI1 7127426 YP_002387026.1 CDS ECIAI1_1594 NC_011741.1 1675975 1676247 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1675975..1676247) Escherichia coli IAI1 7128368 YP_002387027.1 CDS cspI NC_011741.1 1676477 1676689 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9484881; Product type h : extrachromosomal origin; cold shock protein; Qin prophage complement(1676477..1676689) Escherichia coli IAI1 7126771 YP_002387028.1 CDS ydfP NC_011741.1 1677053 1677550 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1677053..1677550) Escherichia coli IAI1 7126851 YP_002387029.1 CDS ydfQ NC_011741.1 1677547 1678080 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated lysozyme; Qin prophage complement(1677547..1678080) Escherichia coli IAI1 7127427 YP_002387030.1 CDS ydfR NC_011741.1 1678077 1678388 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1678077..1678388) Escherichia coli IAI1 7127428 YP_002387031.1 CDS essQ NC_011741.1 1678393 1678608 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative S lysis protein; Qin prophage complement(1678393..1678608) Escherichia coli IAI1 7127429 YP_002387032.1 CDS cspB NC_011741.1 1679362 1679577 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293754, 94293756, 9439003; Product type h : extrachromosomal origin; cold shock protein; Qin prophage complement(1679362..1679577) Escherichia coli IAI1 7125091 YP_002387033.1 CDS cspF NC_011741.1 1679878 1680090 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9484881, 8022261, 9439003; Product type h : extrachromosomal origin; cold shock protein; Qin prophage 1679878..1680090 Escherichia coli IAI1 7125932 YP_002387034.1 CDS ydfT NC_011741.1 1680512 1681264 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative antitermination protein Q; Qin prophage complement(1680512..1681264) Escherichia coli IAI1 7125936 YP_002387035.1 CDS ydfU NC_011741.1 1681278 1682327 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1681278..1682327) Escherichia coli IAI1 7127430 YP_002387036.1 CDS rem NC_011741.1 1682674 1682925 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2990907; Product type h : extrachromosomal origin; hypothetical protein complement(1682674..1682925) Escherichia coli IAI1 7127431 YP_002387037.1 CDS relE NC_011741.1 1683369 1683656 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21592958, 99141390, 2990907; Product type h : extrachromosomal origin; toxin of the RelE-RelB toxin-antitoxin system; Qin prophage complement(1683369..1683656) Escherichia coli IAI1 7124960 YP_002387038.1 CDS relB NC_011741.1 1683656 1683895 R Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor; bifunctional antitoxin/transcriptional repressor RelB complement(1683656..1683895) Escherichia coli IAI1 7124959 YP_002387039.1 CDS ECIAI1_1607 NC_011741.1 1683926 1684087 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(1683926..1684087) Escherichia coli IAI1 7124958 YP_002387040.1 CDS flxA NC_011741.1 1684428 1684760 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9358034; Product type h : extrachromosomal origin; hypothetical protein 1684428..1684760 Escherichia coli IAI1 7126772 YP_002387041.1 CDS ECIAI1_1611 NC_011741.1 1686716 1686898 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1686716..1686898 Escherichia coli IAI1 7126774 YP_002387042.1 CDS ECIAI1_1612 NC_011741.1 1687657 1687782 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1687657..1687782) Escherichia coli IAI1 7126775 YP_002387043.1 CDS ECIAI1_1613 NC_011741.1 1687832 1687942 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1687832..1687942) Escherichia coli IAI1 7126776 YP_002387044.1 CDS ECIAI1_1614 NC_011741.1 1688205 1688561 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1688205..1688561) Escherichia coli IAI1 7126777 YP_002387045.1 CDS ECIAI1_1615 NC_011741.1 1688558 1688980 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1688558..1688980) Escherichia coli IAI1 7126778 YP_002387046.1 CDS ECIAI1_1616 NC_011741.1 1689021 1690040 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1689021..1690040) Escherichia coli IAI1 7126779 YP_002387047.1 CDS ECIAI1_1617 NC_011741.1 1689967 1690488 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1689967..1690488) Escherichia coli IAI1 7126780 YP_002387048.1 CDS dicC NC_011741.1 1690472 1690702 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88232418, 3532030; Product type h : extrachromosomal origin; DNA-binding transcriptional regulator DicC complement(1690472..1690702) Escherichia coli IAI1 7126781 YP_002387049.1 CDS dicA NC_011741.1 1690786 1691193 D The transcriptional repressor of DicA (divison cell) has a hypothetical DNA binding domain. It represses the transcription of dicB and dicC, but its specific role in cellular replication and mode of action are still unknown.; transcriptional repressor DicA 1690786..1691193 Escherichia coli IAI1 7124584 YP_002387050.1 CDS ydfA NC_011741.1 1691282 1691515 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1691282..1691515 Escherichia coli IAI1 7124583 YP_002387051.1 CDS ydfB NC_011741.1 1691517 1691645 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1691517..1691645 Escherichia coli IAI1 7127417 YP_002387052.1 CDS ydfC NC_011741.1 1691675 1691893 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1691675..1691893 Escherichia coli IAI1 7127418 YP_002387053.1 CDS ECIAI1_1623 NC_011741.1 1691897 1692112 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1691897..1692112) Escherichia coli IAI1 7127419 YP_002387054.1 CDS ECIAI1_1624 NC_011741.1 1692346 1692639 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative regulator of cell division encoded by prophage 1692346..1692639 Escherichia coli IAI1 7124585 YP_002387055.1 CDS ydfD NC_011741.1 1692636 1692827 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1692636..1692827 Escherichia coli IAI1 7126783 YP_002387056.1 CDS ECIAI1_1626 NC_011741.1 1692884 1695391 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative exonuclease from phage origin 1692884..1695391 Escherichia coli IAI1 7127420 YP_002387057.1 CDS xis NC_011741.1 1695464 1695715 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; prophage excisionase 1695464..1695715 Escherichia coli IAI1 7126784 YP_002387058.1 CDS intQ NC_011741.1 1695735 1697030 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative defective integrase; Qin prophage 1695735..1697030 Escherichia coli IAI1 7126473 YP_002387059.1 CDS ECIAI1_1629 NC_011741.1 1697032 1697160 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1697032..1697160) Escherichia coli IAI1 7126073 YP_002387060.1 CDS rspB NC_011741.1 1697218 1698237 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7545940; Product type pe : putative enzyme; putative dehydrogenase complement(1697218..1698237) Escherichia coli IAI1 7126785 YP_002387061.1 CDS rspA NC_011741.1 1698249 1699463 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 93341455, 94310441; Product type pe : putative enzyme; putative enolase/dehydratase complement(1698249..1699463) Escherichia coli IAI1 7128441 YP_002387062.1 CDS ynfA NC_011741.1 1699669 1699995 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1699669..1699995) Escherichia coli IAI1 7128439 YP_002387063.1 CDS ynfB NC_011741.1 1700130 1700471 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1700130..1700471 Escherichia coli IAI1 7127561 YP_002387064.1 CDS speG NC_011741.1 1700506 1701066 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94357898; Product type e : enzyme; spermidine N1-acetyltransferase 1700506..1701066 Escherichia coli IAI1 7127562 YP_002387065.1 CDS ynfC NC_011741.1 1701069 1701779 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1701069..1701779) Escherichia coli IAI1 7127960 YP_002387066.1 CDS ynfD NC_011741.1 1701887 1702192 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9868784; hypothetical protein 1701887..1702192 Escherichia coli IAI1 7127563 YP_002387067.1 CDS ynfE NC_011741.1 1702391 1704817 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type e : enzyme; oxidoreductase subunit 1702391..1704817 Escherichia coli IAI1 7127564 YP_002387068.1 CDS ynfF NC_011741.1 1704878 1707301 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type e : enzyme; oxidoreductase subunit 1704878..1707301 Escherichia coli IAI1 7127565 YP_002387069.1 CDS ynfG NC_011741.1 1707312 1707929 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type c : carrier; oxidoreductase, Fe-S subunit 1707312..1707929 Escherichia coli IAI1 7127566 YP_002387070.1 CDS ynfH NC_011741.1 1707931 1708785 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type m : membrane component; oxidoreductase, membrane subunit 1707931..1708785 Escherichia coli IAI1 7127567 YP_002387071.1 CDS dmsD NC_011741.1 1708828 1709442 D binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1708828..1709442 Escherichia coli IAI1 7127568 YP_002387072.1 CDS clcB NC_011741.1 1709638 1710894 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12384697; Product type pt : putative transporter; putative voltage-gated ClC-type chloride channel ClcB 1709638..1710894 Escherichia coli IAI1 7124603 YP_002387073.1 CDS ynfK NC_011741.1 1710847 1711542 R DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; putative dithiobiotin synthetase complement(1710847..1711542) Escherichia coli IAI1 7126330 YP_002387074.1 CDS dgsA NC_011741.1 1711667 1712887 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10318813, 20490366, 6989798, 99340206, 99395104, 99398866, 7766024; Product type r : regulator; DNA-binding transcriptional repressor complement(1711667..1712887) Escherichia coli IAI1 7127569 YP_002387075.1 CDS ynfL NC_011741.1 1713022 1713915 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1713022..1713915) Escherichia coli IAI1 7124577 YP_002387076.1 CDS ynfM NC_011741.1 1714022 1715275 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1714022..1715275 Escherichia coli IAI1 7127570 YP_002387077.1 CDS asr NC_011741.1 1715699 1716007 D required for growth and survival under moderately acid conditions; acid shock protein 1715699..1716007 Escherichia coli IAI1 7127571 YP_002387078.1 CDS ydgD NC_011741.1 1716283 1717104 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported metallopeptidase 1716283..1717104 Escherichia coli IAI1 7126268 YP_002387079.1 CDS mdtI NC_011741.1 1717143 1717472 R with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI complement(1717143..1717472) Escherichia coli IAI1 7127435 YP_002387080.1 CDS mdtJ NC_011741.1 1717459 1717824 R with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ complement(1717459..1717824) Escherichia coli IAI1 7124228 YP_002387081.1 CDS tqsA NC_011741.1 1718236 1719270 D transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; putative transport protein 1718236..1719270 Escherichia coli IAI1 7124229 YP_002387082.1 CDS pntB NC_011741.1 1719295 1720683 R catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase complement(1719295..1720683) Escherichia coli IAI1 7127436 YP_002387083.1 CDS pntA NC_011741.1 1720694 1722226 R forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha complement(1720694..1722226) Escherichia coli IAI1 7126109 YP_002387084.1 CDS ydgH NC_011741.1 1722750 1723694 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1722750..1723694 Escherichia coli IAI1 7126108 YP_002387085.1 CDS ydgI NC_011741.1 1723880 1725262 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1311296; Product type pt : putative transporter; putative arginine/ornithine antiporter transporter 1723880..1725262 Escherichia coli IAI1 7127437 YP_002387086.1 CDS folM NC_011741.1 1725299 1726021 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14617668; Product type e : enzyme; short chain dehydrogenase 1725299..1726021 Escherichia coli IAI1 7127438 YP_002387087.1 CDS ydgC NC_011741.1 1726018 1726353 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1726018..1726353) Escherichia coli IAI1 7127265 YP_002387088.1 CDS rstA NC_011741.1 1726473 1727201 D response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 1726473..1727201 Escherichia coli IAI1 7127434 YP_002387089.1 CDS rstB NC_011741.1 1727205 1728506 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93086426, 1495392, 1925016, 2646639; Product type r : regulator; sensor protein RstB 1727205..1728506 Escherichia coli IAI1 7128444 YP_002387090.1 CDS tus NC_011741.1 1728582 1729511 D binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 1728582..1729511 Escherichia coli IAI1 7128445 YP_002387091.1 CDS fumC NC_011741.1 1729508 1730911 R class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase complement(1729508..1730911) Escherichia coli IAI1 7127518 YP_002387092.1 CDS fumA NC_011741.1 1731054 1732700 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88193096, 88268900, 92011457, 3005475, 6328431, 9298646; Product type e : enzyme; fumarate hydratase complement(1731054..1732700) Escherichia coli IAI1 7128254 YP_002387093.1 CDS manA NC_011741.1 1732899 1734074 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82100097, 6397402; Product type e : enzyme; mannose-6-phosphate isomerase 1732899..1734074 Escherichia coli IAI1 7128252 YP_002387094.1 CDS ydgA NC_011741.1 1734175 1735683 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1734175..1735683 Escherichia coli IAI1 7127667 YP_002387095.1 CDS uidC NC_011741.1 1735728 1736993 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15774881; Product type t : transporter; putative outer membrane porin protein complement(1735728..1736993) Escherichia coli IAI1 7127433 YP_002387096.1 CDS uidB NC_011741.1 1737032 1738405 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3534890; Product type t : transporter; glucuronide transporter complement(1737032..1738405) Escherichia coli IAI1 7125533 YP_002387097.1 CDS uidA NC_011741.1 1738402 1740213 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87041472, 88038341, 2103475, 8125312; Product type e : enzyme; beta-D-glucuronidase complement(1738402..1740213) Escherichia coli IAI1 7125532 YP_002387098.1 CDS uidR NC_011741.1 1740601 1741191 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88038341, 2823062, 3934044, 11115104; Product type r : regulator; DNA-binding transcriptional repressor complement(1740601..1741191) Escherichia coli IAI1 7125531 YP_002387099.1 CDS hdhA NC_011741.1 1741420 1742187 R Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase complement(1741420..1742187) Escherichia coli IAI1 7125534 YP_002387100.1 CDS malI NC_011741.1 1742299 1743327 R regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI complement(1742299..1743327) Escherichia coli IAI1 7128503 YP_002387101.1 CDS malX NC_011741.1 1743502 1745094 D phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional PTS system maltose and glucose-specific transporter subunits IICB 1743502..1745094 Escherichia coli IAI1 7127657 YP_002387102.1 CDS malY NC_011741.1 1745104 1746276 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20164451, 7665481, 91310596; Product type e : enzyme; bifunctional beta-cystathionase, PLP-dependent and regulator of maltose regulon 1745104..1746276 Escherichia coli IAI1 7127664 YP_002387103.1 CDS add NC_011741.1 1746380 1747381 D catalyzes the formation of inosine from adenosine; adenosine deaminase 1746380..1747381 Escherichia coli IAI1 7127665 YP_002387104.1 CDS ydgJ NC_011741.1 1747416 1748456 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(1747416..1748456) Escherichia coli IAI1 7125715 YP_002387105.1 CDS blr NC_011741.1 1748624 1748824 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20392465, 10931331; Product type m : membrane component; beta-lactam resistance membrane protein 1748624..1748824 Escherichia coli IAI1 7127439 YP_002387106.1 CDS ydgT NC_011741.1 1749097 1749312 D YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein 1749097..1749312 Escherichia coli IAI1 7124417 YP_002387107.1 CDS ydgK NC_011741.1 1749398 1749838 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1749398..1749838 Escherichia coli IAI1 7127442 YP_002387108.1 CDS rsxA NC_011741.1 1749915 1750496 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411911, 10637328, 12773378; Product type pm : putative membrane component; Na(+)-translocating NADH-quinone reductase subunit E 1749915..1750496 Escherichia coli IAI1 7127440 YP_002387109.1 CDS rsxB NC_011741.1 1750496 1751074 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 1750496..1751074 Escherichia coli IAI1 7128447 YP_002387110.1 CDS rsxC NC_011741.1 1751067 1753193 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 1751067..1753193 Escherichia coli IAI1 7128448 YP_002387111.1 CDS rnfD NC_011741.1 1753194 1754252 D RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 1753194..1754252 Escherichia coli IAI1 7124544 YP_002387112.1 CDS rsxG NC_011741.1 1754256 1754876 D part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 1754256..1754876 Escherichia coli IAI1 7124625 YP_002387113.1 CDS rsxE NC_011741.1 1754880 1755575 D in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex RsxE subunit 1754880..1755575 Escherichia coli IAI1 7124627 YP_002387114.1 CDS nth NC_011741.1 1755575 1756210 D DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III 1755575..1756210 Escherichia coli IAI1 7124626 YP_002387115.1 CDS tppB NC_011741.1 1756821 1758323 D mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; putative tripeptide transporter permease 1756821..1758323 Escherichia coli IAI1 7125950 YP_002387116.1 CDS gst NC_011741.1 1758429 1759034 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95096109, 2185038, 9680481; Product type e : enzyme; glutathionine S-transferase 1758429..1759034 Escherichia coli IAI1 7127441 YP_002387117.1 CDS pdxY NC_011741.1 1759078 1759941 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase complement(1759078..1759941) Escherichia coli IAI1 7128475 YP_002387118.1 CDS tyrS NC_011741.1 1760000 1761274 R catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase complement(1760000..1761274) Escherichia coli IAI1 7124168 YP_002387119.1 CDS pdxH NC_011741.1 1761403 1762059 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase complement(1761403..1762059) Escherichia coli IAI1 7127529 YP_002387120.1 CDS ydhA NC_011741.1 1762118 1762447 R MliC; membrane-bound lysozyme inhibitor of c-type lysozyme; lysozyme inhibitor complement(1762118..1762447) Escherichia coli IAI1 7124165 YP_002387121.1 CDS anmK NC_011741.1 1762545 1763654 R catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase complement(1762545..1763654) Escherichia coli IAI1 7127443 YP_002387122.1 CDS slyB NC_011741.1 1763928 1764395 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8544813; Product type lp : lipoprotein; putative outer membrane lipoprotein 1763928..1764395 Escherichia coli IAI1 7125763 YP_002387123.1 CDS slyA NC_011741.1 1764442 1764876 R Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA complement(1764442..1764876) Escherichia coli IAI1 7127933 YP_002387124.1 CDS ydhI NC_011741.1 1765077 1765313 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1765077..1765313 Escherichia coli IAI1 7127932 YP_002387125.1 CDS ydhJ NC_011741.1 1765316 1766173 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12900028; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase 1765316..1766173 Escherichia coli IAI1 7127448 YP_002387126.1 CDS ydhK NC_011741.1 1766173 1768185 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1766173..1768185 Escherichia coli IAI1 7127449 YP_002387127.1 CDS sodC NC_011741.1 1768186 1768707 R SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase complement(1768186..1768707) Escherichia coli IAI1 7127530 YP_002387128.1 CDS ydhF NC_011741.1 1768788 1769684 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(1768788..1769684) Escherichia coli IAI1 7127943 YP_002387129.1 CDS ydhL NC_011741.1 1769733 1770143 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1769733..1770143) Escherichia coli IAI1 7127447 YP_002387130.1 CDS ydhM NC_011741.1 1770159 1770674 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1770159..1770674 Escherichia coli IAI1 7127289 YP_002387131.1 CDS nemA NC_011741.1 1770711 1771808 D FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase 1770711..1771808 Escherichia coli IAI1 7127290 YP_002387132.1 CDS gloA NC_011741.1 1771889 1772296 D Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 1771889..1772296 Escherichia coli IAI1 7127866 YP_002387133.1 CDS rnt NC_011741.1 1772399 1773046 D Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 1772399..1773046 Escherichia coli IAI1 7128332 YP_002387134.1 CDS lhr NC_011741.1 1773139 1777755 D similar to the DNA and RNA helicase superfamily II and eukaryotic DEAD family of helicases; longest known protein in E. coli; putative ATP-dependent helicase Lhr 1773139..1777755 Escherichia coli IAI1 7128612 YP_002387135.1 CDS ydhD NC_011741.1 1777806 1778153 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15833738, 15840565, 11950925, 12730244; Product type e : enzyme; hypothetical protein complement(1777806..1778153) Escherichia coli IAI1 7126417 YP_002387136.1 CDS ydhO NC_011741.1 1778488 1779303 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported hydrolase 1778488..1779303 Escherichia coli IAI1 7127446 YP_002387137.1 CDS sodB NC_011741.1 1779431 1780012 D SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 1779431..1780012 Escherichia coli IAI1 7127291 YP_002387138.1 CDS ydhP NC_011741.1 1780158 1781327 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative efflux protein; MFS family complement(1780158..1781327) Escherichia coli IAI1 7127942 YP_002387139.1 CDS purR NC_011741.1 1781881 1782906 D binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 1781881..1782906 Escherichia coli IAI1 7127292 YP_002387140.1 CDS ydhB NC_011741.1 1782903 1783835 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2404765; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1782903..1783835) Escherichia coli IAI1 7126555 YP_002387141.1 CDS ydhC NC_011741.1 1783948 1785159 D uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 1783948..1785159 Escherichia coli IAI1 7127444 YP_002387142.1 CDS cfa NC_011741.1 1785450 1786598 D catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane fatty acyl phospholipid synthase 1785450..1786598 Escherichia coli IAI1 7127445 YP_002387143.1 CDS ribC NC_011741.1 1786638 1787279 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(1786638..1787279) Escherichia coli IAI1 7126299 YP_002387144.1 CDS mdtK NC_011741.1 1787494 1788867 D NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1787494..1788867 Escherichia coli IAI1 7124994 YP_002387145.1 CDS ydhQ NC_011741.1 1788908 1790164 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1788908..1790164) Escherichia coli IAI1 7124230 YP_002387146.1 CDS ydhR NC_011741.1 1790737 1791042 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1790737..1791042 Escherichia coli IAI1 7127990 YP_002387147.1 CDS ydhS NC_011741.1 1791168 1792772 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1791168..1792772 Escherichia coli IAI1 7127294 YP_002387148.1 CDS ydhT NC_011741.1 1792784 1793596 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1792784..1793596) Escherichia coli IAI1 7127295 YP_002387149.1 CDS ydhU NC_011741.1 1793600 1794385 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative cytochrome b subunit of a reductase complement(1793600..1794385) Escherichia coli IAI1 7127296 YP_002387150.1 CDS ydhX NC_011741.1 1794382 1795050 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S ferridoxin-type subunit of oxidoreductase complement(1794382..1795050) Escherichia coli IAI1 7127297 YP_002387151.1 CDS ydhW NC_011741.1 1795114 1795761 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1795114..1795761) Escherichia coli IAI1 7127300 YP_002387152.1 CDS ydhV NC_011741.1 1795765 1797867 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(1795765..1797867) Escherichia coli IAI1 7127299 YP_002387153.1 CDS ydhY NC_011741.1 1797888 1798514 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; hypothetical protein complement(1797888..1798514) Escherichia coli IAI1 7127298 YP_002387154.1 CDS ydhZ NC_011741.1 1798970 1799179 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1798970..1799179) Escherichia coli IAI1 7127301 YP_002387155.1 CDS pykF NC_011741.1 1799736 1801148 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1799736..1801148 Escherichia coli IAI1 7127302 YP_002387156.1 CDS lpp NC_011741.1 1801459 1801695 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 334727, 338599, 322142, 353292, 391404, 4261992, 4575979, 6765942; Product type lp : lipoprotein; murein lipoprotein 1801459..1801695 Escherichia coli IAI1 7126568 YP_002387157.1 CDS ynhG NC_011741.1 1801759 1802763 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1801759..1802763) Escherichia coli IAI1 7127619 YP_002387158.1 CDS sufE NC_011741.1 1802912 1803328 R Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE complement(1802912..1803328) Escherichia coli IAI1 7127574 YP_002387159.1 CDS sufS NC_011741.1 1803341 1804561 R catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase complement(1803341..1804561) Escherichia coli IAI1 7126196 YP_002387160.1 CDS sufD NC_011741.1 1804558 1805829 R with SufBC activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufD complement(1804558..1805829) Escherichia coli IAI1 7126198 YP_002387161.1 CDS sufC NC_011741.1 1805804 1806550 R part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase ATPase complement(1805804..1806550) Escherichia coli IAI1 7126195 YP_002387162.1 CDS sufB NC_011741.1 1806560 1808047 R with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB complement(1806560..1808047) Escherichia coli IAI1 7126194 YP_002387163.1 CDS sufA NC_011741.1 1808056 1808424 R functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein complement(1808056..1808424) Escherichia coli IAI1 7126193 YP_002387164.1 CDS ydiH NC_011741.1 1808973 1809242 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1808973..1809242) Escherichia coli IAI1 7124651 YP_002387165.1 CDS ydiI NC_011741.1 1809261 1809671 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme; hypothetical protein complement(1809261..1809671) Escherichia coli IAI1 7127308 YP_002387166.1 CDS ydiJ NC_011741.1 1809668 1812724 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11102686; Product type pe : putative enzyme; putative conserved FAD-linked oxidoreductase complement(1809668..1812724) Escherichia coli IAI1 7127309 YP_002387167.1 CDS ydiK NC_011741.1 1813113 1814225 D YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; hypothetical protein 1813113..1814225 Escherichia coli IAI1 7127310 YP_002387168.1 CDS ECIAI1_1741 NC_011741.1 1814415 1814591 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1814415..1814591) Escherichia coli IAI1 7128406 YP_002387169.1 CDS ydiL NC_011741.1 1814654 1815010 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1814654..1815010 Escherichia coli IAI1 7126793 YP_002387170.1 CDS ydiM NC_011741.1 1815110 1816324 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1815110..1816324 Escherichia coli IAI1 7127312 YP_002387171.1 CDS ydiN NC_011741.1 1816551 1817816 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 1816551..1817816 Escherichia coli IAI1 7127313 YP_002387172.1 CDS ydiB NC_011741.1 1817828 1818694 D YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase 1817828..1818694 Escherichia coli IAI1 7127314 YP_002387173.1 CDS aroD NC_011741.1 1818725 1819483 D catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1818725..1819483 Escherichia coli IAI1 7127304 YP_002387174.1 CDS ydiF NC_011741.1 1819627 1821222 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16253988; Product type e : enzyme; short chain acyl-CoA transferase subunit alpha/beta 1819627..1821222 Escherichia coli IAI1 7125805 YP_002387175.1 CDS ydiO NC_011741.1 1821236 1822387 D may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; putative acyl-CoA dehydrogenase 1821236..1822387 Escherichia coli IAI1 7127307 YP_002387176.1 CDS ydiP NC_011741.1 1822430 1823341 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1822430..1823341) Escherichia coli IAI1 7127315 YP_002387177.1 CDS ECIAI1_1750 NC_011741.1 1823444 1823620 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1823444..1823620) Escherichia coli IAI1 7127316 YP_002387178.1 CDS ydiQ NC_011741.1 1823657 1824421 D YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; putative electron transfer flavoprotein YdiQ 1823657..1824421 Escherichia coli IAI1 7126794 YP_002387179.1 CDS ydiR NC_011741.1 1824441 1825379 D May play a role in a redox process; electron transfer flavoprotein subunit YdiR 1824441..1825379 Escherichia coli IAI1 7127317 YP_002387180.1 CDS ydiS NC_011741.1 1825435 1826724 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; hypothetical protein 1825435..1826724 Escherichia coli IAI1 7127318 YP_002387181.1 CDS ydiT NC_011741.1 1826721 1827014 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S ferredoxin-type oxidoreductase subunit 1826721..1827014 Escherichia coli IAI1 7127319 YP_002387182.1 CDS ydiD NC_011741.1 1827017 1828717 D acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids; short chain acyl-CoA synthetase 1827017..1828717 Escherichia coli IAI1 7127320 YP_002387183.1 CDS pps NC_011741.1 1828774 1831152 R catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase complement(1828774..1831152) Escherichia coli IAI1 7127305 YP_002387184.1 CDS ECIAI1_1757 NC_011741.1 1831206 1831373 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1831206..1831373) Escherichia coli IAI1 7126138 YP_002387185.1 CDS ydiA NC_011741.1 1831485 1832318 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1831485..1832318 Escherichia coli IAI1 7126795 YP_002387186.1 CDS aroH NC_011741.1 1832475 1833521 D tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 1832475..1833521 Escherichia coli IAI1 7127303 YP_002387187.1 CDS ydiE NC_011741.1 1833653 1833844 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15039350; hypothetical protein 1833653..1833844 Escherichia coli IAI1 7125809 YP_002387188.1 CDS ydiV NC_011741.1 1835347 1836060 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1835347..1836060) Escherichia coli IAI1 7127322 YP_002387189.1 CDS nlpC NC_011741.1 1836307 1836771 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12620121; Product type lp : lipoprotein; putative peptidase lipoprotein complement(1836307..1836771) Escherichia coli IAI1 7127323 YP_002387190.1 CDS btuD NC_011741.1 1836849 1837598 R ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase complement(1836849..1837598) Escherichia coli IAI1 7127889 YP_002387191.1 CDS btuE NC_011741.1 1837598 1838149 R similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; putative glutathione peroxidase complement(1837598..1838149) Escherichia coli IAI1 7124425 YP_002387192.1 CDS btuC NC_011741.1 1838212 1839192 R with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease complement(1838212..1839192) Escherichia coli IAI1 7124426 YP_002387193.1 CDS ihfA NC_011741.1 1839293 1839592 R This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha complement(1839293..1839592) Escherichia coli IAI1 7124424 YP_002387194.1 CDS pheT NC_011741.1 1839597 1841984 R catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta complement(1839597..1841984) Escherichia coli IAI1 7126047 YP_002387195.1 CDS pheS NC_011741.1 1841999 1842982 R catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha complement(1841999..1842982) Escherichia coli IAI1 7124197 YP_002387197.1 CDS rplT NC_011741.1 1843433 1843789 R binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 complement(1843433..1843789) Escherichia coli IAI1 7124194 YP_002387198.1 CDS rpmI NC_011741.1 1843842 1844039 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93085722, 10094780, 3298224, 3542048, 6325158; Product type s : structure; 50S ribosomal protein L35 complement(1843842..1844039) Escherichia coli IAI1 7128381 YP_002387199.1 CDS thrS NC_011741.1 1844682 1846610 R catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase complement(1844682..1846610) Escherichia coli IAI1 7126066 YP_002387200.1 CDS ECIAI1_1776 NC_011741.1 1846895 1846966 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1846895..1846966 Escherichia coli IAI1 7126256 YP_002387201.1 CDS ydiY NC_011741.1 1849338 1850096 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1849338..1850096) Escherichia coli IAI1 7126798 YP_002387202.1 CDS pfkB NC_011741.1 1850383 1851312 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 78194149, 88292964, 6235149, 6310120; Product type e : enzyme; 6-phosphofructokinase 2 1850383..1851312 Escherichia coli IAI1 7127324 YP_002387203.1 CDS ydiZ NC_011741.1 1851413 1851703 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1851413..1851703 Escherichia coli IAI1 7124179 YP_002387204.1 CDS yniA NC_011741.1 1851809 1852669 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase/kinase 1851809..1852669 Escherichia coli IAI1 7127325 YP_002387205.1 CDS yniB NC_011741.1 1852710 1853246 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1852710..1853246) Escherichia coli IAI1 7127575 YP_002387206.1 CDS yniC NC_011741.1 1853393 1854061 D YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase 1853393..1854061 Escherichia coli IAI1 7127576 YP_002387207.1 CDS ydjM NC_011741.1 1854224 1854814 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10760155; Product type pm : putative membrane component; hypothetical protein 1854224..1854814 Escherichia coli IAI1 7127577 YP_002387208.1 CDS ECIAI1_1787 NC_011741.1 1854746 1854874 R hypothetical protein complement(1854746..1854874) Escherichia coli IAI1 7127335 YP_002387209.1 CDS ydjN NC_011741.1 1854947 1856338 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative cation-acid symporter 1854947..1856338 Escherichia coli IAI1 7126799 YP_002387210.1 CDS cedA NC_011741.1 1857434 1857697 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9427399; Product type cp : cell process; cell division modulator complement(1857434..1857697) Escherichia coli IAI1 7127338 YP_002387211.1 CDS katE NC_011741.1 1857880 1860141 D Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II 1857880..1860141 Escherichia coli IAI1 7126298 YP_002387212.1 CDS chbG NC_011741.1 1860188 1860946 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 20042356, 1987146, 2179047, 8121401, 9405618; hypothetical protein complement(1860188..1860946) Escherichia coli IAI1 7126092 YP_002387213.1 CDS chbF NC_011741.1 1860959 1862311 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20042356, 90185127, 9405618; Product type e : enzyme; cryptic phospho-beta-glucosidase complement(1860959..1862311) Escherichia coli IAI1 7126307 YP_002387214.1 CDS chbR NC_011741.1 1862416 1863258 R represses the celABCDF-ydjC operon involved in carbon uptake; DNA-binding transcriptional regulator ChbR complement(1862416..1863258) Escherichia coli IAI1 7126306 YP_002387215.1 CDS chbA NC_011741.1 1863266 1863616 R catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA complement(1863266..1863616) Escherichia coli IAI1 7126308 YP_002387216.1 CDS chbC NC_011741.1 1863667 1865025 R catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC complement(1863667..1865025) Escherichia coli IAI1 7126303 YP_002387217.1 CDS chbB NC_011741.1 1865110 1865430 R catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB complement(1865110..1865430) Escherichia coli IAI1 7126305 YP_002387218.1 CDS osmE NC_011741.1 1865729 1866067 R osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE complement(1865729..1866067) Escherichia coli IAI1 7126304 YP_002387219.1 CDS nadE NC_011741.1 1866269 1867096 D catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1866269..1867096 Escherichia coli IAI1 7125997 YP_002387220.1 CDS ydjQ NC_011741.1 1867326 1868213 D 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease 1867326..1868213 Escherichia coli IAI1 7124515 YP_002387221.1 CDS ydjR NC_011741.1 1868173 1868748 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21862596; hypothetical protein complement(1868173..1868748) Escherichia coli IAI1 7127339 YP_002387222.1 CDS spy NC_011741.1 1868951 1869436 R periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; periplasmic protein complement(1868951..1869436) Escherichia coli IAI1 7127340 YP_002387223.1 CDS astE NC_011741.1 1869766 1870734 R catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase complement(1869766..1870734) Escherichia coli IAI1 7127966 YP_002387224.1 CDS astB NC_011741.1 1870727 1872070 R catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation; succinylarginine dihydrolase complement(1870727..1872070) Escherichia coli IAI1 7126273 YP_002387225.1 CDS astD NC_011741.1 1872067 1873545 R a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase complement(1872067..1873545) Escherichia coli IAI1 7126270 YP_002387226.1 CDS astA NC_011741.1 1873542 1874576 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14675764, 98361920; Product type e : enzyme; arginine succinyltransferase complement(1873542..1874576) Escherichia coli IAI1 7126272 YP_002387227.1 CDS astC NC_011741.1 1874573 1875793 R catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate; bifunctional succinylornithine transaminase/acetylornithine transaminase complement(1874573..1875793) Escherichia coli IAI1 7126269 YP_002387228.1 CDS xthA NC_011741.1 1876239 1877045 D removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 1876239..1877045 Escherichia coli IAI1 7126271 YP_002387229.1 CDS ydjX NC_011741.1 1877212 1877922 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1877212..1877922 Escherichia coli IAI1 7126476 YP_002387230.1 CDS ydjY NC_011741.1 1877927 1878604 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1877927..1878604 Escherichia coli IAI1 7127341 YP_002387231.1 CDS ydjZ NC_011741.1 1878619 1879326 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1878619..1879326 Escherichia coli IAI1 7127342 YP_002387232.1 CDS ynjA NC_011741.1 1879326 1879874 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1879326..1879874 Escherichia coli IAI1 7127343 YP_002387233.1 CDS ynjB NC_011741.1 1879884 1881050 D Evidence 4 : Homologs of previously reported genes of unknown function; putative ABC transporter solute-binding protein 1879884..1881050 Escherichia coli IAI1 7127578 YP_002387234.1 CDS ynjC NC_011741.1 1881068 1882558 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter membrane protein 1881068..1882558 Escherichia coli IAI1 7127579 YP_002387235.1 CDS ynjD NC_011741.1 1882558 1883211 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sulfate/thiosulfate ABC transporter ATP-binding protein 1882558..1883211 Escherichia coli IAI1 7127580 YP_002387236.1 CDS ynjE NC_011741.1 1883278 1884585 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported thiosulfate sulfur transferase / thiosulfate binding protein 1883278..1884585 Escherichia coli IAI1 7127581 YP_002387237.1 CDS ynjF NC_011741.1 1884594 1885214 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type m : membrane component; putative phosphatidyl transferase, inner membrane protein complement(1884594..1885214) Escherichia coli IAI1 7127582 YP_002387238.1 CDS nudG NC_011741.1 1885301 1885708 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101911; Product type e : enzyme; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 1885301..1885708 Escherichia coli IAI1 7127583 YP_002387239.1 CDS ynjH NC_011741.1 1885674 1885946 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1885674..1885946) Escherichia coli IAI1 7125956 YP_002387240.1 CDS gdhA NC_011741.1 1886182 1887525 D converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1886182..1887525 Escherichia coli IAI1 7127584 YP_002387241.1 CDS ynjI NC_011741.1 1887642 1888682 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1887642..1888682) Escherichia coli IAI1 7128300 YP_002387242.1 CDS topB NC_011741.1 1888810 1890771 R decatenates replicating daughter chromosomes; DNA topoisomerase III complement(1888810..1890771) Escherichia coli IAI1 7127585 YP_002387243.1 CDS selD NC_011741.1 1890776 1891819 R catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase complement(1890776..1891819) Escherichia coli IAI1 7127465 YP_002387244.1 CDS ECIAI1_1826 NC_011741.1 1891761 1891910 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1891761..1891910) Escherichia coli IAI1 7126968 YP_002387245.1 CDS ydjA NC_011741.1 1891936 1892487 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(1891936..1892487) Escherichia coli IAI1 7126800 YP_002387246.1 CDS ECIAI1_1828 NC_011741.1 1892541 1892705 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1892541..1892705 Escherichia coli IAI1 7127326 YP_002387247.1 CDS sppA NC_011741.1 1892648 1894504 D SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 1892648..1894504 Escherichia coli IAI1 7126801 YP_002387248.1 CDS ansA NC_011741.1 1894671 1895687 D converts asparagine to aspartate and ammonia; cytoplasmic asparaginase I 1894671..1895687 Escherichia coli IAI1 7127963 YP_002387249.1 CDS pncA NC_011741.1 1895698 1896339 D catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase 1895698..1896339 Escherichia coli IAI1 7125764 YP_002387250.1 CDS ydjE NC_011741.1 1896432 1897790 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter complement(1896432..1897790) Escherichia coli IAI1 7126105 YP_002387251.1 CDS ydjF NC_011741.1 1897907 1898665 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1897907..1898665) Escherichia coli IAI1 7127327 YP_002387252.1 CDS ydjG NC_011741.1 1898802 1899782 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(1898802..1899782) Escherichia coli IAI1 7127328 YP_002387253.1 CDS ydjH NC_011741.1 1899792 1900739 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar kinase complement(1899792..1900739) Escherichia coli IAI1 7127329 YP_002387254.1 CDS ydjI NC_011741.1 1900744 1901580 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldolase complement(1900744..1901580) Escherichia coli IAI1 7127330 YP_002387255.1 CDS ydjJ NC_011741.1 1901601 1902644 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12897001; Product type pe : putative enzyme; putative iditol dehydrogenase complement(1901601..1902644) Escherichia coli IAI1 7127331 YP_002387256.1 CDS ydjK NC_011741.1 1902661 1904040 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter complement(1902661..1904040) Escherichia coli IAI1 7127332 YP_002387257.1 CDS ydjL NC_011741.1 1904067 1905143 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(1904067..1905143) Escherichia coli IAI1 7127333 YP_002387258.1 CDS yeaC NC_011741.1 1905513 1905785 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1905513..1905785) Escherichia coli IAI1 7127334 YP_002387259.1 CDS msrB NC_011741.1 1905827 1906240 R this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B complement(1905827..1906240) Escherichia coli IAI1 7127345 YP_002387260.1 CDS gapA NC_011741.1 1906582 1907577 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 775311, 94131963, 98361923, 1862091, 2124629, 2990926, 7896119, 8636984, 9298646; Product type e : enzyme; glyceraldehyde-3-phosphate dehydrogenase A 1906582..1907577 Escherichia coli IAI1 7124482 YP_002387261.1 CDS yeaD NC_011741.1 1907661 1908545 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1907661..1908545 Escherichia coli IAI1 7128277 YP_002387262.1 CDS yeaE NC_011741.1 1908596 1909450 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(1908596..1909450) Escherichia coli IAI1 7127346 YP_002387263.1 CDS mipA NC_011741.1 1909540 1910286 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10037771, 20267815; Product type f : factor; scaffolding protein for murein synthesizing machinery complement(1909540..1910286) Escherichia coli IAI1 7127347 YP_002387264.1 CDS yeaG NC_011741.1 1910722 1912656 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1910722..1912656 Escherichia coli IAI1 7124279 YP_002387265.1 CDS yeaH NC_011741.1 1912769 1914052 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1912769..1914052 Escherichia coli IAI1 7127348 YP_002387266.1 CDS yeaI NC_011741.1 1914199 1915674 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase 1914199..1915674 Escherichia coli IAI1 7127349 YP_002387267.1 CDS yeaJ NC_011741.1 1915855 1917345 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase 1915855..1917345 Escherichia coli IAI1 7127350 YP_002387268.1 CDS yeaK NC_011741.1 1917388 1917891 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1917388..1917891 Escherichia coli IAI1 7127351 YP_002387269.1 CDS ECIAI1_1852 NC_011741.1 1917892 1918044 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1917892..1918044) Escherichia coli IAI1 7127352 YP_002387270.1 CDS yeaL NC_011741.1 1918166 1918612 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1918166..1918612 Escherichia coli IAI1 7126802 YP_002387271.1 CDS yeaM NC_011741.1 1918569 1919390 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1918569..1919390) Escherichia coli IAI1 7127353 YP_002387272.1 CDS yeaN NC_011741.1 1919487 1920668 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1919487..1920668 Escherichia coli IAI1 7127354 YP_002387273.1 CDS yeaO NC_011741.1 1920723 1921070 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1920723..1921070 Escherichia coli IAI1 7127355 YP_002387274.1 CDS yoaF NC_011741.1 1921092 1921346 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1921092..1921346) Escherichia coli IAI1 7127356 YP_002387275.1 CDS yeaP NC_011741.1 1921529 1922554 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase 1921529..1922554 Escherichia coli IAI1 7127590 YP_002387276.1 CDS yeaQ NC_011741.1 1922821 1923069 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1922821..1923069) Escherichia coli IAI1 7127357 YP_002387277.1 CDS ECIAI1_1861 NC_011741.1 1923081 1923266 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1923081..1923266) Escherichia coli IAI1 7127358 YP_002387278.1 CDS ydcM NC_011741.1 1923296 1924504 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase complement(1923296..1924504) Escherichia coli IAI1 7126803 YP_002387279.1 CDS ECIAI1_1863 NC_011741.1 1923722 1923853 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1923722..1923853 Escherichia coli IAI1 7127381 YP_002387280.1 CDS ECIAI1_1864 NC_011741.1 1924482 1924628 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1924482..1924628) Escherichia coli IAI1 7126804 YP_002387281.1 CDS ECIAI1_1865 NC_011741.1 1924959 1925147 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1924959..1925147) Escherichia coli IAI1 7126805 YP_002387282.1 CDS yeaR NC_011741.1 1925151 1925510 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1925151..1925510) Escherichia coli IAI1 7126806 YP_002387283.1 CDS yeaS NC_011741.1 1925683 1926321 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; leucine export protein LeuE complement(1925683..1926321) Escherichia coli IAI1 7127359 YP_002387284.1 CDS yeaT NC_011741.1 1926448 1927371 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1926448..1927371) Escherichia coli IAI1 7127360 YP_002387285.1 CDS yeaU NC_011741.1 1927474 1928559 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative tartrate dehydrogenase 1927474..1928559 Escherichia coli IAI1 7127361 YP_002387286.1 CDS yeaV NC_011741.1 1928975 1930420 D member of the betaine, carnitine, choline transporter (BCCT) family; unknown function; putative transporter 1928975..1930420 Escherichia coli IAI1 7127362 YP_002387287.1 CDS yeaW NC_011741.1 1930452 1931576 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 2Fe-2S cluster-containing dioxygenase subunit 1930452..1931576 Escherichia coli IAI1 7127363 YP_002387288.1 CDS yeaX NC_011741.1 1931632 1932597 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dioxygenase subunit 1931632..1932597 Escherichia coli IAI1 7127364 YP_002387289.1 CDS rnd NC_011741.1 1932651 1933778 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88289400, 89053950, 93015723, 8107670; Product type e : enzyme; ribonuclease D complement(1932651..1933778) Escherichia coli IAI1 7127365 YP_002387290.1 CDS fadD NC_011741.1 1933848 1935533 R Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(1933848..1935533) Escherichia coli IAI1 7125019 YP_002387291.1 CDS yeaY NC_011741.1 1935738 1936319 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16079137; Product type lp : lipoprotein; putative outer membrane-associated lipoprotein complement(1935738..1936319) Escherichia coli IAI1 7127063 YP_002387292.1 CDS yeaZ NC_011741.1 1936359 1937054 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase complement(1936359..1937054) Escherichia coli IAI1 7127366 YP_002387293.1 CDS yoaA NC_011741.1 1937112 1939022 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-dependent helicase complement(1937112..1939022) Escherichia coli IAI1 7127367 YP_002387294.1 CDS yoaB NC_011741.1 1939154 1939498 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1939154..1939498 Escherichia coli IAI1 7127586 YP_002387295.1 CDS yoaC NC_011741.1 1939861 1940220 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1939861..1940220 Escherichia coli IAI1 7127587 YP_002387296.1 CDS yoaH NC_011741.1 1940340 1940519 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1940340..1940519) Escherichia coli IAI1 7127588 YP_002387297.1 CDS pabB NC_011741.1 1940593 1941954 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88025006, 91067712, 91302313, 96011382, 6330050, 7896119; Product type e : enzyme; aminodeoxychorismate synthase subunit I 1940593..1941954 Escherichia coli IAI1 7127591 YP_002387298.1 CDS yeaB NC_011741.1 1941958 1942536 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pe : putative enzyme; hypothetical protein 1941958..1942536 Escherichia coli IAI1 7124147 YP_002387299.1 CDS sdaA NC_011741.1 1942720 1944084 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15155761, 89359152, 91056090, 93170282; Product type e : enzyme; L-serine deaminase I 1942720..1944084 Escherichia coli IAI1 7127344 YP_002387300.1 CDS adrB NC_011741.1 1944215 1945813 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16513732; Product type pe : putative enzyme; putative cyclic di-GMP phosphodiesterase 1944215..1945813 Escherichia coli IAI1 7124683 YP_002387301.1 CDS yoaE NC_011741.1 1945817 1947373 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein complement(1945817..1947373) Escherichia coli IAI1 7125723 YP_002387302.1 CDS manX NC_011741.1 1947836 1948807 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87165962, 90036983, 8131846, 8676384, 9074635, 9298646; Product type t : transporter; PTS system mannose-specific transporter subunit IIAB 1947836..1948807 Escherichia coli IAI1 7127589 YP_002387303.1 CDS manY NC_011741.1 1948870 1949670 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10473571, 87165962, 90036983, 94086520, 97128775, 7811395, 8774730; Product type t : transporter; mannose-specific PTS system transporter subunit IIC 1948870..1949670 Escherichia coli IAI1 7127668 YP_002387304.1 CDS manZ NC_011741.1 1949674 1950534 D hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 1949674..1950534 Escherichia coli IAI1 7127669 YP_002387305.1 CDS yobD NC_011741.1 1950589 1951047 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1950589..1951047 Escherichia coli IAI1 7127670 YP_002387306.1 CDS ECIAI1_1890 NC_011741.1 1951234 1951479 D Evidence 6 : Doubtful CDS; hypothetical protein 1951234..1951479 Escherichia coli IAI1 7127594 YP_002387307.1 CDS yebN NC_011741.1 1951476 1952042 D membrane protein YebN; hypothetical protein 1951476..1952042 Escherichia coli IAI1 7126807 YP_002387308.1 CDS rrmA NC_011741.1 1952039 1952848 R methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase A complement(1952039..1952848) Escherichia coli IAI1 7125194 YP_002387309.1 CDS cspC NC_011741.1 1953014 1953223 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20345064, 21101802, 94293754, 12071744, 7984109, 8022261, 9298646, 9868784, 9921691; Product type f : factor; cold shock-like protein CspC complement(1953014..1953223) Escherichia coli IAI1 7128429 YP_002387310.1 CDS yobF NC_011741.1 1953236 1953379 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1953236..1953379) Escherichia coli IAI1 7125933 YP_002387311.1 CDS yebO NC_011741.1 1954048 1954335 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1954048..1954335) Escherichia coli IAI1 7127595 YP_002387312.1 CDS yobG NC_011741.1 1954410 1954553 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1954410..1954553) Escherichia coli IAI1 7125195 YP_002387313.1 CDS yobH NC_011741.1 1954712 1954951 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1954712..1954951 Escherichia coli IAI1 7127596 YP_002387314.1 CDS kdgR NC_011741.1 1955094 1955885 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659677, 4359651; Product type r : regulator; DNA-binding transcriptional repressor KdgR complement(1955094..1955885) Escherichia coli IAI1 7127597 YP_002387315.1 CDS yebQ NC_011741.1 1956062 1957435 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1956062..1957435 Escherichia coli IAI1 7126371 YP_002387316.1 CDS htpX NC_011741.1 1957481 1958362 R putative metalloprotease; heat shock protein HtpX complement(1957481..1958362) Escherichia coli IAI1 7125196 YP_002387317.1 CDS prc NC_011741.1 1958554 1960602 R Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease complement(1958554..1960602) Escherichia coli IAI1 7125319 YP_002387318.1 CDS proQ NC_011741.1 1960622 1961275 R affects solute and DNA transport through an unknown mechanism; putative solute/DNA competence effector complement(1960622..1961275) Escherichia coli IAI1 7126143 YP_002387319.1 CDS yebR NC_011741.1 1961372 1961923 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1961372..1961923) Escherichia coli IAI1 7126160 YP_002387320.1 CDS yebS NC_011741.1 1961999 1963282 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1961999..1963282 Escherichia coli IAI1 7125197 YP_002387321.1 CDS yebT NC_011741.1 1963251 1965884 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1963251..1965884 Escherichia coli IAI1 7125198 YP_002387322.1 CDS yebU NC_011741.1 1965964 1967403 D in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF 1965964..1967403 Escherichia coli IAI1 7125199 YP_002387323.1 CDS yebV NC_011741.1 1967521 1967757 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1967521..1967757 Escherichia coli IAI1 7125200 YP_002387324.1 CDS yebW NC_011741.1 1967778 1968053 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1967778..1968053 Escherichia coli IAI1 7125201 YP_002387325.1 CDS pphA NC_011741.1 1968054 1968710 R Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins; serine/threonine protein phosphatase 1 complement(1968054..1968710) Escherichia coli IAI1 7125202 YP_002387326.1 CDS yebY NC_011741.1 1969106 1969447 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1969106..1969447) Escherichia coli IAI1 7126808 YP_002387327.1 CDS yebZ NC_011741.1 1969460 1970332 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1969460..1970332) Escherichia coli IAI1 7125203 YP_002387328.1 CDS yobA NC_011741.1 1970336 1970710 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1970336..1970710) Escherichia coli IAI1 7125204 YP_002387329.1 CDS holE NC_011741.1 1970849 1971079 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15090519, 92147649, 92156151, 94131961, 1575709, 8341603, 8505306; Product type e : enzyme; DNA polymerase III subunit theta 1970849..1971079 Escherichia coli IAI1 7127592 YP_002387330.1 CDS yobB NC_011741.1 1971181 1971837 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1971181..1971837 Escherichia coli IAI1 7125295 YP_002387331.1 CDS exoX NC_011741.1 1971861 1972523 D 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 1971861..1972523 Escherichia coli IAI1 7127593 YP_002387332.1 CDS ptrB NC_011741.1 1972520 1974580 R PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 complement(1972520..1974580) Escherichia coli IAI1 7127049 YP_002387333.1 CDS yebE NC_011741.1 1974789 1975448 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1974789..1975448) Escherichia coli IAI1 7126537 YP_002387334.1 CDS yebF NC_011741.1 1975775 1976143 R secreted protein; unknown function; hypothetical protein complement(1975775..1976143) Escherichia coli IAI1 7125190 YP_002387335.1 CDS yebG NC_011741.1 1976198 1976488 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9368369, 99403401; Product type cp : cell process; DNA damage-inducible protein YebG complement(1976198..1976488) Escherichia coli IAI1 7125191 YP_002387336.1 CDS purT NC_011741.1 1976622 1977800 D non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 1976622..1977800 Escherichia coli IAI1 7125192 YP_002387337.1 CDS eda NC_011741.1 1977856 1978497 R catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase complement(1977856..1978497) Escherichia coli IAI1 7126556 YP_002387338.1 CDS edd NC_011741.1 1978534 1980345 R catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase complement(1978534..1980345) Escherichia coli IAI1 7125048 YP_002387339.1 CDS zwf NC_011741.1 1980580 1982055 R catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase complement(1980580..1982055) Escherichia coli IAI1 7125049 YP_002387340.1 CDS yebK NC_011741.1 1982393 1983262 D Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR 1982393..1983262 Escherichia coli IAI1 7128136 YP_002387341.1 CDS pykA NC_011741.1 1983390 1984832 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1983390..1984832 Escherichia coli IAI1 7125193 YP_002387342.1 CDS ECIAI1_1928 NC_011741.1 1984892 1985701 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1984892..1985701) Escherichia coli IAI1 7126567 YP_002387343.1 CDS ECIAI1_1929 NC_011741.1 1985756 1986595 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1985756..1986595) Escherichia coli IAI1 7126809 YP_002387344.1 CDS ECIAI1_1930 NC_011741.1 1986688 1987494 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Metal-dependent hydrolase complement(1986688..1987494) Escherichia coli IAI1 7126810 YP_002387345.1 CDS ECIAI1_1931 NC_011741.1 1987507 1989306 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2482332, 12547200; Product type e : enzyme; Neopullulanase complement(1987507..1989306) Escherichia coli IAI1 7126811 YP_002387346.1 CDS ECIAI1_1932 NC_011741.1 1989324 1990163 R Evidence 2b : Function of strongly homologous gene; PubMedId : 8594196; Product type t : transporter; maltosaccharide ABC transporter permease complement(1989324..1990163) Escherichia coli IAI1 7126812 YP_002387347.1 CDS ECIAI1_1933 NC_011741.1 1990160 1991449 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8594196; Product type pt : putative transporter; putative sugar ABC transporter permease/inner membrane protein CymF complement(1990160..1991449) Escherichia coli IAI1 7126813 YP_002387348.1 CDS ECIAI1_1934 NC_011741.1 1991452 1992774 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8594196; Product type pt : putative transporter; putative sugar ABC transporter maltose-binding protein CymE complement(1991452..1992774) Escherichia coli IAI1 7126814 YP_002387349.1 CDS ECIAI1_1935 NC_011741.1 1992957 1993994 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8594196; Product type pt : putative transporter; putative exported protein porin 1992957..1993994 Escherichia coli IAI1 7126815 YP_002387350.1 CDS ECIAI1_1936 NC_011741.1 1994013 1994969 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8594196; Product type pe : putative enzyme; putative UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 1994013..1994969 Escherichia coli IAI1 7126816 YP_002387351.1 CDS ECIAI1_1937 NC_011741.1 1995060 1995548 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative CymC protein 1995060..1995548 Escherichia coli IAI1 7126817 YP_002387352.1 CDS ECIAI1_1938 NC_011741.1 1995631 1996758 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8594196; Product type t : transporter; sugar ABC transporter ATP-binding protein CymD 1995631..1996758 Escherichia coli IAI1 7126818 YP_002387353.1 CDS ECIAI1_1939 NC_011741.1 1997120 1997974 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8594196; hypothetical protein 1997120..1997974 Escherichia coli IAI1 7126819 YP_002387354.1 CDS ECIAI1_1940 NC_011741.1 1998063 1999931 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1998063..1999931 Escherichia coli IAI1 7126820 YP_002387355.1 CDS ECIAI1_1941 NC_011741.1 1999968 2003042 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative alpha-mannosidase 1999968..2003042 Escherichia coli IAI1 7126821 YP_002387356.1 CDS lpxM NC_011741.1 2003131 2004102 R Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase complement(2003131..2004102) Escherichia coli IAI1 7126822 YP_002387357.1 CDS yebA NC_011741.1 2004222 2005544 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1732206; Product type pe : putative enzyme; hypothetical protein complement(2004222..2005544) Escherichia coli IAI1 7127629 YP_002387358.1 CDS znuA NC_011741.1 2005560 2006492 R involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic component complement(2005560..2006492) Escherichia coli IAI1 7127368 YP_002387359.1 CDS znuC NC_011741.1 2006571 2007326 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase 2006571..2007326 Escherichia coli IAI1 7128128 YP_002387360.1 CDS znuB NC_011741.1 2007323 2008108 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane component 2007323..2008108 Escherichia coli IAI1 7128130 YP_002387361.1 CDS ruvB NC_011741.1 2008255 2009265 R promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB complement(2008255..2009265) Escherichia coli IAI1 7128129 YP_002387362.1 CDS ruvA NC_011741.1 2009274 2009885 R plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA complement(2009274..2009885) Escherichia coli IAI1 7124645 YP_002387363.1 CDS yebB NC_011741.1 2010160 2010762 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2010160..2010762 Escherichia coli IAI1 7124644 YP_002387364.1 CDS ruvC NC_011741.1 2010764 2011285 R endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase complement(2010764..2011285) Escherichia coli IAI1 7124542 YP_002387365.1 CDS yebC NC_011741.1 2011320 2012060 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2011320..2012060) Escherichia coli IAI1 7124646 YP_002387366.1 CDS ntpA NC_011741.1 2012089 2012541 R converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase complement(2012089..2012541) Escherichia coli IAI1 7125189 YP_002387367.1 CDS aspS NC_011741.1 2012659 2014431 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(2012659..2014431) Escherichia coli IAI1 7125951 YP_002387368.1 CDS yecD NC_011741.1 2014741 2015307 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2014741..2015307 Escherichia coli IAI1 7126267 YP_002387369.1 CDS yecE NC_011741.1 2015304 2016122 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2129559, 7984428; hypothetical protein 2015304..2016122 Escherichia coli IAI1 7125207 YP_002387370.1 CDS yecN NC_011741.1 2016175 2016570 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2016175..2016570 Escherichia coli IAI1 7125208 YP_002387371.1 CDS yecO NC_011741.1 2016611 2017354 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11746687; Product type e : enzyme; AdoMet-dependent methyltransferase 2016611..2017354 Escherichia coli IAI1 7125215 YP_002387372.1 CDS yecP NC_011741.1 2017351 2018322 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2017351..2018322 Escherichia coli IAI1 7125216 YP_002387373.1 CDS torZ NC_011741.1 2018487 2020916 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97077292, 11004177; Product type e : enzyme; trimethylamine N-oxide reductase system III, catalytic subunit complement(2018487..2020916) Escherichia coli IAI1 7125217 YP_002387374.1 CDS torY NC_011741.1 2020941 2022041 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461225, 8919859; Product type c : carrier; TMAO reductase III (TorYZ), cytochrome c-type subunit complement(2020941..2022041) Escherichia coli IAI1 7127473 YP_002387375.1 CDS cutC NC_011741.1 2022429 2023175 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95362641, 7635807; Product type t : transporter; copper homeostasis protein CutC complement(2022429..2023175) Escherichia coli IAI1 7127472 YP_002387376.1 CDS yecM NC_011741.1 2023189 2023755 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12660999; Product type pe : putative enzyme; hypothetical protein complement(2023189..2023755) Escherichia coli IAI1 7126866 YP_002387377.1 CDS argS NC_011741.1 2023971 2025704 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 2023971..2025704 Escherichia coli IAI1 7125214 YP_002387378.1 CDS yecT NC_011741.1 2025881 2026369 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2025881..2026369 Escherichia coli IAI1 7125798 YP_002387379.1 CDS flhE NC_011741.1 2026489 2026881 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8002587, 1482109, 89181349; hypothetical protein complement(2026489..2026881) Escherichia coli IAI1 7125220 YP_002387380.1 CDS flhA NC_011741.1 2026881 2028959 R membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA complement(2026881..2028959) Escherichia coli IAI1 7127230 YP_002387381.1 CDS flhB NC_011741.1 2028952 2030100 R membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB complement(2028952..2030100) Escherichia coli IAI1 7127226 YP_002387382.1 CDS cheZ NC_011741.1 2030302 2030946 R cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis regulator CheZ complement(2030302..2030946) Escherichia coli IAI1 7127227 YP_002387383.1 CDS cheY NC_011741.1 2030957 2031346 R chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY complement(2030957..2031346) Escherichia coli IAI1 7126314 YP_002387384.1 CDS cheB NC_011741.1 2031361 2032410 R regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase complement(2031361..2032410) Escherichia coli IAI1 7126313 YP_002387385.1 CDS cheR NC_011741.1 2032413 2033273 R methylates the MCP; chemotaxis methyltransferase CheR complement(2032413..2033273) Escherichia coli IAI1 7126310 YP_002387386.1 CDS tap NC_011741.1 2033292 2034893 R mediates taxis toward dipeptides; methyl-accepting protein IV complement(2033292..2034893) Escherichia coli IAI1 7126311 YP_002387387.1 CDS tar NC_011741.1 2034939 2036600 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90094243, 92165727, 6305515, 9315712; Product type r : regulator; methyl-accepting chemotaxis protein II complement(2034939..2036600) Escherichia coli IAI1 7126211 YP_002387388.1 CDS cheW NC_011741.1 2036745 2037248 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91126073, 91296802, 91317710, 2002011, 3510184; Product type r : regulator; purine-binding chemotaxis protein complement(2036745..2037248) Escherichia coli IAI1 7124434 YP_002387389.1 CDS cheA NC_011741.1 2037269 2039233 R chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA complement(2037269..2039233) Escherichia coli IAI1 7126312 YP_002387390.1 CDS motB NC_011741.1 2039238 2040164 R with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB complement(2039238..2040164) Escherichia coli IAI1 7126309 YP_002387391.1 CDS motA NC_011741.1 2040161 2041048 R With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA complement(2040161..2041048) Escherichia coli IAI1 7125831 YP_002387392.1 CDS flhC NC_011741.1 2041175 2041753 R With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC complement(2041175..2041753) Escherichia coli IAI1 7124307 YP_002387393.1 CDS flhD NC_011741.1 2041756 2042115 R with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD complement(2041756..2042115) Escherichia coli IAI1 7127228 YP_002387394.1 CDS yecG NC_011741.1 2042886 2043314 D ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspC 2042886..2043314 Escherichia coli IAI1 7127229 YP_002387395.1 CDS otsA NC_011741.1 2043321 2044745 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92078100, 92121128, 93302496, 8045430; Product type e : enzyme; trehalose-6-phosphate synthase complement(2043321..2044745) Escherichia coli IAI1 7125210 YP_002387396.1 CDS otsB NC_011741.1 2044720 2045520 R biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase complement(2044720..2045520) Escherichia coli IAI1 7125999 YP_002387397.1 CDS araH NC_011741.1 2045687 2046676 R Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter permease complement(2045687..2046676) Escherichia coli IAI1 7126000 YP_002387398.1 CDS araG NC_011741.1 2046688 2048202 R Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein complement(2046688..2048202) Escherichia coli IAI1 7125782 YP_002387399.1 CDS araF NC_011741.1 2048272 2049261 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89255061, 90375534, 2445996, 326784, 326785, 6885805, 7031057, 9298646; Product type t : transporter; L-arabinose ABC transporter periplasmic-binding protein complement(2048272..2049261) Escherichia coli IAI1 7125781 YP_002387400.1 CDS yecI NC_011741.1 2050058 2050561 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative ferritin-like protein 2050058..2050561 Escherichia coli IAI1 7125780 YP_002387401.1 CDS yecJ NC_011741.1 2050640 2050891 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2050640..2050891) Escherichia coli IAI1 7125212 YP_002387402.1 CDS ECIAI1_1988 NC_011741.1 2051003 2051149 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2051003..2051149 Escherichia coli IAI1 7126088 YP_002387403.1 CDS yecR NC_011741.1 2051351 2051674 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2051351..2051674 Escherichia coli IAI1 7126823 YP_002387404.1 CDS ftn NC_011741.1 2051845 2052342 D cytoplasmic iron storage protein; ferritin 2051845..2052342 Escherichia coli IAI1 7125218 YP_002387405.1 CDS yecH NC_011741.1 2052380 2052619 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2052380..2052619) Escherichia coli IAI1 7128231 YP_002387406.1 CDS tyrP NC_011741.1 2052810 2054021 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89008121, 2022620; Product type t : transporter; tyrosine transporter 2052810..2054021 Escherichia coli IAI1 7125211 YP_002387407.1 CDS yecA NC_011741.1 2054083 2054748 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2054083..2054748) Escherichia coli IAI1 7127527 YP_002387408.1 CDS pgsA NC_011741.1 2055398 2055946 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 381294, 7007311, 94253011, 1323047, 3003065, 8917447; Product type e : enzyme; phosphatidylglycerophosphate synthetase complement(2055398..2055946) Escherichia coli IAI1 7128052 YP_002387409.1 CDS uvrC NC_011741.1 2056003 2057835 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C complement(2056003..2057835) Escherichia coli IAI1 7124191 YP_002387410.1 CDS uvrY NC_011741.1 2057832 2058488 R in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator complement(2057832..2058488) Escherichia coli IAI1 7125557 YP_002387411.1 CDS ECIAI1_1999 NC_011741.1 2058784 2058960 D Evidence 6 : Doubtful CDS; hypothetical protein 2058784..2058960 Escherichia coli IAI1 7125559 YP_002387412.1 CDS yecF NC_011741.1 2058947 2059171 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3515318, 7567469; hypothetical protein 2058947..2059171 Escherichia coli IAI1 7126824 YP_002387413.1 CDS sdiA NC_011741.1 2059238 2059960 R regulates genes involved in cell division; DNA-binding transcriptional activator SdiA complement(2059238..2059960) Escherichia coli IAI1 7125209 YP_002387414.1 CDS yecC NC_011741.1 2060190 2060942 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino-acid ABC transporter ATP-binding protein YecC complement(2060190..2060942) Escherichia coli IAI1 7124690 YP_002387415.1 CDS yecS NC_011741.1 2060939 2061607 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease complement(2060939..2061607) Escherichia coli IAI1 7125206 YP_002387416.1 CDS yedO NC_011741.1 2061622 2062608 R catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase complement(2061622..2062608) Escherichia coli IAI1 7125219 YP_002387417.1 CDS fliY NC_011741.1 2062713 2063513 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96125225, 8450713, 8774726, 9298646, 9740056; Product type t : transporter; cystine transporter subunit complement(2062713..2063513) Escherichia coli IAI1 7125228 YP_002387418.1 CDS fliZ NC_011741.1 2063601 2064152 R expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence; flagella biosynthesis protein FliZ complement(2063601..2064152) Escherichia coli IAI1 7127250 YP_002387419.1 CDS fliA NC_011741.1 2064198 2064917 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor complement(2064198..2064917) Escherichia coli IAI1 7127251 YP_002387420.1 CDS ECIAI1_2008 NC_011741.1 2064991 2065110 D hypothetical protein 2064991..2065110 Escherichia coli IAI1 7127231 YP_002387421.1 CDS fliC NC_011741.1 2065237 2067069 R structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes; flagellin complement(2065237..2067069) Escherichia coli IAI1 7126825 YP_002387422.1 CDS fliD NC_011741.1 2067335 2068741 D involved in flagellin assembly; flagellar capping protein 2067335..2068741 Escherichia coli IAI1 7127232 YP_002387423.1 CDS fliS NC_011741.1 2068766 2069176 D flagellin specific chaperone; flagellar protein FliS 2068766..2069176 Escherichia coli IAI1 7127233 YP_002387424.1 CDS fliT NC_011741.1 2069176 2069541 D binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT 2069176..2069541 Escherichia coli IAI1 7127248 YP_002387425.1 CDS amyA NC_011741.1 2069619 2071106 D converts 1,4-alpha-D-glucans to maltodextrin; cytoplasmic alpha-amylase 2069619..2071106 Escherichia coli IAI1 7127249 YP_002387426.1 CDS yedD NC_011741.1 2071140 2071553 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2071140..2071553) Escherichia coli IAI1 7125762 YP_002387427.1 CDS yedE NC_011741.1 2071740 2072945 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2071740..2072945 Escherichia coli IAI1 7125222 YP_002387428.1 CDS yedF NC_011741.1 2072942 2073175 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2072942..2073175 Escherichia coli IAI1 7125223 YP_002387429.1 CDS yedK NC_011741.1 2073282 2073950 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2073282..2073950 Escherichia coli IAI1 7125224 YP_002387430.1 CDS fliE NC_011741.1 2074343 2074657 R forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE complement(2074343..2074657) Escherichia coli IAI1 7125227 YP_002387431.1 CDS fliF NC_011741.1 2074872 2076530 D the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein 2074872..2076530 Escherichia coli IAI1 7127234 YP_002387432.1 CDS fliG NC_011741.1 2076523 2077518 D One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 2076523..2077518 Escherichia coli IAI1 7127235 YP_002387433.1 CDS fliH NC_011741.1 2077511 2078197 D binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 2077511..2078197 Escherichia coli IAI1 7127236 YP_002387434.1 CDS fliI NC_011741.1 2078197 2079570 D involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 2078197..2079570 Escherichia coli IAI1 7127237 YP_002387435.1 CDS fliJ NC_011741.1 2079589 2080032 D rod/hook and filament chaperone; flagellar biosynthesis chaperone 2079589..2080032 Escherichia coli IAI1 7127238 YP_002387436.1 CDS fliK NC_011741.1 2080029 2081156 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1482109, 8631687; Product type s : structure; flagellar hook-length control protein 2080029..2081156 Escherichia coli IAI1 7127239 YP_002387437.1 CDS fliL NC_011741.1 2081261 2081725 D interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body-associated protein FliL 2081261..2081725 Escherichia coli IAI1 7127240 YP_002387438.1 CDS fliM NC_011741.1 2081730 2082734 D with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 2081730..2082734 Escherichia coli IAI1 7127241 YP_002387439.1 CDS fliN NC_011741.1 2082731 2083144 D One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN 2082731..2083144 Escherichia coli IAI1 7127242 YP_002387440.1 CDS fliO NC_011741.1 2083147 2083512 D with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO 2083147..2083512 Escherichia coli IAI1 7127243 YP_002387441.1 CDS fliP NC_011741.1 2083512 2084249 D FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 2083512..2084249 Escherichia coli IAI1 7127244 YP_002387442.1 CDS fliQ NC_011741.1 2084259 2084528 D with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ 2084259..2084528 Escherichia coli IAI1 7127245 YP_002387443.1 CDS fliR NC_011741.1 2084536 2085321 D FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR 2084536..2085321 Escherichia coli IAI1 7127246 YP_002387444.1 CDS rcsA NC_011741.1 2085611 2086234 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14514676, 14766922, 20167175, 90130299, 91154130, 92048476, 9882673, 7534408; Product type r : regulator; DNA-binding transcriptional activator, co-regulator with RcsB 2085611..2086234 Escherichia coli IAI1 7127247 YP_002387445.1 CDS dsrB NC_011741.1 2086278 2086466 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 96324407, 7534408; hypothetical protein complement(2086278..2086466) Escherichia coli IAI1 7126598 YP_002387446.1 CDS yodD NC_011741.1 2086629 2086856 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2086629..2086856 Escherichia coli IAI1 7125030 YP_002387447.1 CDS yedP NC_011741.1 2087154 2087969 D catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate; mannosyl-3-phosphoglycerate phosphatase 2087154..2087969 Escherichia coli IAI1 7125028 YP_002387448.1 CDS yedQ NC_011741.1 2087966 2089660 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16530465; Product type pe : putative enzyme; putative diguanylate cyclase complement(2087966..2089660) Escherichia coli IAI1 7125229 YP_002387449.1 CDS ECIAI1_2037 NC_011741.1 2089581 2089769 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2089581..2089769) Escherichia coli IAI1 7125230 YP_002387450.1 CDS yodC NC_011741.1 2089898 2090080 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2089898..2090080) Escherichia coli IAI1 7126826 YP_002387451.1 CDS yedI NC_011741.1 2090159 2091076 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2090159..2091076) Escherichia coli IAI1 7127600 YP_002387452.1 CDS yedA NC_011741.1 2091249 2092169 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2091249..2092169 Escherichia coli IAI1 7125225 YP_002387453.1 CDS vsr NC_011741.1 2092158 2092628 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330522, 92049708, 94049122, 10360178, 10612397, 10871403, 2527357; Product type e : enzyme; DNA mismatch endonuclease of very short patch repair complement(2092158..2092628) Escherichia coli IAI1 7125221 YP_002387454.1 CDS dcm NC_011741.1 2092609 2094027 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90280700, 91285397, 93367813, 2198248, 2527357; Product type e : enzyme; DNA cytosine methylase complement(2092609..2094027) Escherichia coli IAI1 7125571 YP_002387455.1 CDS yedJ NC_011741.1 2094094 2094789 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pe : putative enzyme; hypothetical protein complement(2094094..2094789) Escherichia coli IAI1 7126923 YP_002387456.1 CDS yedR NC_011741.1 2094829 2095194 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2094829..2095194) Escherichia coli IAI1 7125226 YP_002387457.1 CDS ECIAI1_2045 NC_011741.1 2095731 2096948 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9642192; Product type m : membrane component; Porin OmpN 2095731..2096948 Escherichia coli IAI1 7128435 YP_002387458.1 CDS hchA NC_011741.1 2097541 2098392 D Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 2097541..2098392 Escherichia coli IAI1 7126827 YP_002387459.1 CDS yedV NC_011741.1 2098500 2099858 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15522865; Product type rc : receptor; sensory kinase in two-component regulatory system with YedW complement(2098500..2099858) Escherichia coli IAI1 7128495 YP_002387460.1 CDS yedW NC_011741.1 2099858 2100529 R induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW complement(2099858..2100529) Escherichia coli IAI1 7125232 YP_002387461.1 CDS yedX NC_011741.1 2100662 2101075 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2100662..2101075 Escherichia coli IAI1 7125233 YP_002387462.1 CDS yedY NC_011741.1 2101184 2102188 D in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; putative sulfite oxidase subunit YedY 2101184..2102188 Escherichia coli IAI1 7125234 YP_002387463.1 CDS yedZ NC_011741.1 2102189 2102824 D in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; putative sulfite oxidase subunit YedZ 2102189..2102824 Escherichia coli IAI1 7125235 YP_002387464.1 CDS yodA NC_011741.1 2103081 2103731 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12077457, 12480884, 12909634, 9579078; hypothetical protein 2103081..2103731 Escherichia coli IAI1 7125236 YP_002387465.1 CDS yodB NC_011741.1 2104074 2104604 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16042411; Product type pc : putative carrier; putative cytochrome 2104074..2104604 Escherichia coli IAI1 7127598 YP_002387466.1 CDS yeeI NC_011741.1 2105356 2106153 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2105356..2106153 Escherichia coli IAI1 7128051 YP_002387467.1 CDS yeeJ NC_011741.1 2106830 2113273 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659678; Product type f : factor; adhesin 2106830..2113273 Escherichia coli IAI1 7126828 YP_002387468.1 CDS insF NC_011741.1 2113270 2114136 R Evidence 1b : Function experimentally demonstrated in the studied species; Product type h : extrachromosomal origin; IS3 element protein InsF complement(2113270..2114136) Escherichia coli IAI1 7125242 YP_002387469.1 CDS insE NC_011741.1 2114133 2114441 R Evidence 1b : Function experimentally demonstrated in the studied species; Product type h : extrachromosomal origin; IS3 element protein InsE complement(2114133..2114441) Escherichia coli IAI1 7126070 YP_002387470.1 CDS ECIAI1_2062 NC_011741.1 2114904 2115956 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2114904..2115956) Escherichia coli IAI1 7126069 YP_002387471.1 CDS shiA NC_011741.1 2116271 2117587 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 5332864, 9524262; Product type t : transporter; shikimate transporter 2116271..2117587 Escherichia coli IAI1 7126829 YP_002387472.1 CDS amn NC_011741.1 2117689 2119143 D Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 2117689..2119143 Escherichia coli IAI1 7127928 YP_002387473.1 CDS yeeN NC_011741.1 2119486 2120202 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2119486..2120202 Escherichia coli IAI1 7125755 YP_002387474.1 CDS ECIAI1_2066 NC_011741.1 2120446 2120622 D Evidence 6 : Doubtful CDS; hypothetical protein 2120446..2120622 Escherichia coli IAI1 7125243 YP_002387475.1 CDS yeeO NC_011741.1 2120838 2122478 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16042411; Product type pt : putative transporter; hypothetical protein complement(2120838..2122478) Escherichia coli IAI1 7128050 YP_002387476.1 CDS cbl NC_011741.1 2122599 2123549 R LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl complement(2122599..2123549) Escherichia coli IAI1 7127992 YP_002387477.1 CDS nac NC_011741.1 2123651 2124568 R Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator complement(2123651..2124568) Escherichia coli IAI1 7124450 YP_002387478.1 CDS erfK NC_011741.1 2125026 2125958 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9298646; hypothetical protein complement(2125026..2125958) Escherichia coli IAI1 7127993 YP_002387479.1 CDS cobT NC_011741.1 2126023 2127102 R catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase complement(2126023..2127102) Escherichia coli IAI1 7125089 YP_002387480.1 CDS cobS NC_011741.1 2127114 2127857 R catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase complement(2127114..2127857) Escherichia coli IAI1 7126347 YP_002387481.1 CDS cobU NC_011741.1 2127854 2128399 R catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase complement(2127854..2128399) Escherichia coli IAI1 7126346 YP_002387482.1 CDS yeeX NC_011741.1 2129268 2129663 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2129268..2129663) Escherichia coli IAI1 7126832 YP_002387483.1 CDS yeeA NC_011741.1 2129769 2130827 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2129769..2130827) Escherichia coli IAI1 7125245 YP_002387484.1 CDS sbmC NC_011741.1 2131026 2131499 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11850398, 9442027, 8709849; Product type r : regulator; DNA gyrase inhibitor complement(2131026..2131499) Escherichia coli IAI1 7125237 YP_002387485.1 CDS dacD NC_011741.1 2131618 2132784 R removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase complement(2131618..2132784) Escherichia coli IAI1 7124679 YP_002387486.1 CDS sbcB NC_011741.1 2132973 2134400 D Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 2132973..2134400 Escherichia coli IAI1 7126911 YP_002387487.1 CDS yeeD NC_011741.1 2134443 2134670 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2134443..2134670) Escherichia coli IAI1 7124675 YP_002387488.1 CDS yeeE NC_011741.1 2134684 2135742 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2134684..2135742) Escherichia coli IAI1 7125238 YP_002387489.1 CDS yeeF NC_011741.1 2135921 2137279 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino-acid/amine transporter complement(2135921..2137279) Escherichia coli IAI1 7125239 YP_002387490.1 CDS yeeY NC_011741.1 2137546 2138475 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(2137546..2138475) Escherichia coli IAI1 7125240 YP_002387491.1 CDS yeeZ NC_011741.1 2138521 2139345 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative epimerase complement(2138521..2139345) Escherichia coli IAI1 7125246 YP_002387492.1 CDS yoeB NC_011741.1 2139428 2139682 R Evidence 1b : Function experimentally demonstrated in the studied species; Product type f : factor; toxin of the YoeB-YefM toxin-antitoxin system complement(2139428..2139682) Escherichia coli IAI1 7125247 YP_002387493.1 CDS yefM NC_011741.1 2139679 2139930 R Antitoxin that counteracts the effect of the YoeB toxin; antitoxin YefM complement(2139679..2139930) Escherichia coli IAI1 7127602 YP_002387495.1 CDS hisG NC_011741.1 2140409 2141308 D long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2140409..2141308 Escherichia coli IAI1 7125493 YP_002387496.1 CDS hisD NC_011741.1 2141314 2142618 D catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2141314..2142618 Escherichia coli IAI1 7125273 YP_002387497.1 CDS hisC NC_011741.1 2142615 2143685 D catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2142615..2143685 Escherichia coli IAI1 7125271 YP_002387498.1 CDS hisB NC_011741.1 2143685 2144752 D catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2143685..2144752 Escherichia coli IAI1 7125270 YP_002387499.1 CDS hisH NC_011741.1 2144752 2145342 D with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2144752..2145342 Escherichia coli IAI1 7125269 YP_002387500.1 CDS hisA NC_011741.1 2145342 2146079 D catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2145342..2146079 Escherichia coli IAI1 7125274 YP_002387501.1 CDS hisF NC_011741.1 2146061 2146837 D catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2146061..2146837 Escherichia coli IAI1 7125268 YP_002387502.1 CDS hisI NC_011741.1 2146831 2147439 D catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein 2146831..2147439 Escherichia coli IAI1 7125272 YP_002387503.1 CDS wbdC NC_011741.1 2147478 2148593 R Evidence 2b : Function of strongly homologous gene; PubMedId : 10768928, 9370271, 9573168, 11964144, 4295288, 7536735; Product type e : enzyme; mannosyl transferase complement(2147478..2148593) Escherichia coli IAI1 7125275 YP_002387504.1 CDS wbdB NC_011741.1 2148603 2149760 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10768928, 7536735, 8162191; Product type e : enzyme; mannosyltransferase B complement(2148603..2149760) Escherichia coli IAI1 7125589 YP_002387505.1 CDS wbdA NC_011741.1 2149812 2153453 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9573168, 10768928; Product type e : enzyme; mannosyltransferase complement(2149812..2153453) Escherichia coli IAI1 7125588 YP_002387506.1 CDS wbbD NC_011741.1 2153456 2154733 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9573168, 10768928; Product type pe : putative enzyme; putative SAM-dependent methyltransferase complement(2153456..2154733) Escherichia coli IAI1 7125587 YP_002387507.1 CDS wzt NC_011741.1 2154733 2155947 R Evidence 2b : Function of strongly homologous gene; PubMedId : 10768928, 9573168, 9244257; Product type t : transporter; ATP binding component of ABC-transporter complement(2154733..2155947) Escherichia coli IAI1 7125586 YP_002387508.1 CDS wzm NC_011741.1 2155947 2156741 R Evidence 2b : Function of strongly homologous gene; PubMedId : 10768928, 9573168, 9244257; Product type m : membrane component; Integral membrane component of ABC-transporter complement(2155947..2156741) Escherichia coli IAI1 7126462 YP_002387509.1 CDS cpsG NC_011741.1 2156743 2158149 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7515042, 9004408; Product type e : enzyme; phosphomannomutase (PMM) complement(2156743..2158149) Escherichia coli IAI1 7126461 YP_002387510.1 CDS cpsB NC_011741.1 2158143 2159558 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7896702, 7515042, 9004408, 14993253; Product type e : enzyme; mannose-1-phosphate guanylyltransferase complement(2158143..2159558) Escherichia coli IAI1 7126358 YP_002387511.1 CDS ECIAI1_2105 NC_011741.1 2159840 2160148 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(2159840..2160148) Escherichia coli IAI1 7126356 YP_002387512.1 CDS ECIAI1_2106 NC_011741.1 2160321 2160704 R hypothetical protein complement(2160321..2160704) Escherichia coli IAI1 7126833 YP_002387513.1 CDS cld NC_011741.1 2160708 2161688 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98241528; Product type r : regulator; regulator of length of O-antigen component of lipopolysaccharide chains complement(2160708..2161688) Escherichia coli IAI1 7126834 YP_002387514.1 CDS ugd NC_011741.1 2161831 2162997 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150218, 96326333; Product type e : enzyme; UDP-glucose 6-dehydrogenase complement(2161831..2162997) Escherichia coli IAI1 7126331 YP_002387515.1 CDS gnd NC_011741.1 2163245 2164651 R catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase complement(2163245..2164651) Escherichia coli IAI1 7125521 YP_002387516.1 CDS ECIAI1_2110 NC_011741.1 2164757 2165815 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyltransferase complement(2164757..2165815) Escherichia coli IAI1 7128365 YP_002387517.1 CDS ECIAI1_2111 NC_011741.1 2165838 2166854 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative UDP-glucose 4-epimerase complement(2165838..2166854) Escherichia coli IAI1 7126835 YP_002387518.1 CDS ECIAI1_2112 NC_011741.1 2166894 2167835 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane glycosyl transferase complement(2166894..2167835) Escherichia coli IAI1 7126836 YP_002387519.1 CDS ECIAI1_2113 NC_011741.1 2168090 2168239 D Evidence 6 : Doubtful CDS; hypothetical protein 2168090..2168239 Escherichia coli IAI1 7126837 YP_002387520.1 CDS ECIAI1_2114 NC_011741.1 2169089 2170192 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2169089..2170192) Escherichia coli IAI1 7126838 YP_002387521.1 CDS ECIAI1_2115 NC_011741.1 2170189 2171553 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(2170189..2171553) Escherichia coli IAI1 7126839 YP_002387522.1 CDS galF NC_011741.1 2172982 2173872 R together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalF complement(2172982..2173872) Escherichia coli IAI1 7126840 YP_002387523.1 CDS gne NC_011741.1 2174115 2175110 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976290; Product type e : enzyme; UDP-N-acetylglucosamine 4-epimerase (UDP-GlcNAc 4-epimerase) complement(2174115..2175110) Escherichia coli IAI1 7128269 YP_002387524.1 CDS wcaM NC_011741.1 2175268 2176662 R WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid; putative colanic acid biosynthesis protein complement(2175268..2176662) Escherichia coli IAI1 7128366 YP_002387525.1 CDS wcaL NC_011741.1 2176673 2177893 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme; putative glycosyl transferase complement(2176673..2177893) Escherichia coli IAI1 7126456 YP_002387526.1 CDS wcaK NC_011741.1 2177890 2179170 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333, 8759852, 11004393; Product type pe : putative enzyme; putative pyruvyl transferase complement(2177890..2179170) Escherichia coli IAI1 7126455 YP_002387527.1 CDS wzxC NC_011741.1 2179735 2181213 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 8759852; Product type pt : putative transporter; colanic acid exporter complement(2179735..2181213) Escherichia coli IAI1 7126454 YP_002387528.1 CDS wcaJ NC_011741.1 2181215 2182609 R WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid; putative UDP-glucose lipid carrier transferase complement(2181215..2182609) Escherichia coli IAI1 7126463 YP_002387529.1 CDS cpsG NC_011741.1 2182664 2184034 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106949, 96326333, 7815923, 8759852; Product type e : enzyme; phosphomannomutase complement(2182664..2184034) Escherichia coli IAI1 7126453 YP_002387530.1 CDS cpsB NC_011741.1 2184227 2185663 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82100097, 85006781, 92048476, 93122523, 96326333, 7815923, 8759852; Product type e : enzyme; mannose-1-phosphate guanyltransferase complement(2184227..2185663) Escherichia coli IAI1 7126359 YP_002387531.1 CDS wcaI NC_011741.1 2185666 2186889 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15670885, 96326333; Product type pe : putative enzyme; putative glycosyl transferase complement(2185666..2186889) Escherichia coli IAI1 7126357 YP_002387532.1 CDS nudD NC_011741.1 2186886 2187365 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 10913267, 7592609, 7815923, 8759852; Product type e : enzyme; GDP-mannose mannosyl hydrolase complement(2186886..2187365) Escherichia coli IAI1 7126452 YP_002387533.1 CDS fcl NC_011741.1 2187368 2188333 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 98132401, 9862812, 7815923, 8759852, 9473059; Product type e : enzyme; bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase and GDP-4-dehydro-6-L-deoxygalactose reductase complement(2187368..2188333) Escherichia coli IAI1 7125953 YP_002387534.1 CDS gmd NC_011741.1 2188336 2189457 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20139699, 97400210, 10673432, 7815923, 8759852, 9257704, 14299611; Product type e : enzyme; GDP-D-mannose dehydratase complement(2188336..2189457) Escherichia coli IAI1 7127071 YP_002387535.1 CDS wcaF NC_011741.1 2189483 2190031 R acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); putative colanic acid biosynthesis acetyltransferase WcaF complement(2189483..2190031) Escherichia coli IAI1 7128361 YP_002387536.1 CDS wcaE NC_011741.1 2190047 2190793 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11371548, 96326333, 8759852; Product type pe : putative enzyme; putative glycosyl transferase complement(2190047..2190793) Escherichia coli IAI1 7126451 YP_002387537.1 CDS wcaD NC_011741.1 2190804 2192021 R essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance; putative colanic acid biosynthesis protein complement(2190804..2192021) Escherichia coli IAI1 7126450 YP_002387538.1 CDS wcaC NC_011741.1 2191996 2193213 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme; putative glycosyl transferase complement(2191996..2193213) Escherichia coli IAI1 7126449 YP_002387539.1 CDS wcaB NC_011741.1 2193210 2193698 R acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; putative colanic acid biosynthesis acetyltransferase WcaB complement(2193210..2193698) Escherichia coli IAI1 7126448 YP_002387540.1 CDS wcaA NC_011741.1 2193701 2194540 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme; putative glycosyl transferase complement(2193701..2194540) Escherichia coli IAI1 7126447 YP_002387541.1 CDS wzc NC_011741.1 2194633 2196795 R Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase complement(2194633..2196795) Escherichia coli IAI1 7126969 YP_002387542.1 CDS wzb NC_011741.1 2196798 2197241 R Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase complement(2196798..2197241) Escherichia coli IAI1 7126460 YP_002387543.1 CDS wza NC_011741.1 2197247 2198386 R Evidence 2b : Function of strongly homologous gene; PubMedId : 15090537, 96326333, 8759852, 8763957; Product type lp : lipoprotein; lipoprotein required for capsular polysaccharide translocation through the outer membrane complement(2197247..2198386) Escherichia coli IAI1 7126459 YP_002387544.1 CDS yegH NC_011741.1 2199045 2200628 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 2199045..2200628 Escherichia coli IAI1 7126458 YP_002387545.1 CDS asmA NC_011741.1 2200902 2202755 R YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; putative assembly protein complement(2200902..2202755) Escherichia coli IAI1 7125251 YP_002387546.1 CDS dcd NC_011741.1 2202777 2203358 R Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase complement(2202777..2203358) Escherichia coli IAI1 7126260 YP_002387547.1 CDS udk NC_011741.1 2203450 2204091 R functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase complement(2203450..2204091) Escherichia coli IAI1 7126922 YP_002387548.1 CDS yegE NC_011741.1 2204409 2207726 D contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction; putative sensor protein 2204409..2207726 Escherichia coli IAI1 7125519 YP_002387549.1 CDS alkA NC_011741.1 2207765 2208622 R inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyl-adenine DNA glycosylase II complement(2207765..2208622) Escherichia coli IAI1 7125250 YP_002387550.1 CDS yegD NC_011741.1 2208756 2210108 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 6094528, 7940673, 7984428; Product type pf : putative factor; putative chaperone 2208756..2210108 Escherichia coli IAI1 7125743 YP_002387551.1 CDS yegI NC_011741.1 2210120 2212069 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2210120..2212069) Escherichia coli IAI1 7125249 YP_002387552.1 CDS yegK NC_011741.1 2212057 2212818 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2212057..2212818) Escherichia coli IAI1 7125252 YP_002387553.1 CDS yegL NC_011741.1 2212815 2213474 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2212815..2213474) Escherichia coli IAI1 7125253 YP_002387554.1 CDS mdtA NC_011741.1 2214690 2215937 D Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtA 2214690..2215937 Escherichia coli IAI1 7125494 YP_002387555.1 CDS mdtB NC_011741.1 2215937 2219059 D Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtB 2215937..2219059 Escherichia coli IAI1 7127688 YP_002387556.1 CDS mdtC NC_011741.1 2219060 2222137 D Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC 2219060..2222137 Escherichia coli IAI1 7127689 YP_002387557.1 CDS mdtD NC_011741.1 2222138 2223553 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12107134, 21450803, 8282725; Product type t : transporter; multidrug efflux system protein MdtE 2222138..2223553 Escherichia coli IAI1 7127690 YP_002387558.1 CDS baeS NC_011741.1 2223550 2224953 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94110256, 8282725; Product type r : regulator; signal transduction histidine-protein kinase BaeS 2223550..2224953 Escherichia coli IAI1 7127691 YP_002387559.1 CDS baeR NC_011741.1 2224950 2225672 D response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; DNA-binding transcriptional regulator BaeR 2224950..2225672 Escherichia coli IAI1 7126289 YP_002387560.1 CDS ECIAI1_2156 NC_011741.1 2225632 2225823 D Evidence 6 : Doubtful CDS; hypothetical protein 2225632..2225823 Escherichia coli IAI1 7126288 YP_002387561.1 CDS yegP NC_011741.1 2225863 2226195 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2225863..2226195 Escherichia coli IAI1 7126841 YP_002387562.1 CDS ECIAI1_2158 NC_011741.1 2226404 2226700 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2226404..2226700 Escherichia coli IAI1 7125255 YP_002387563.1 CDS ECIAI1_2159 NC_011741.1 2226702 2226998 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2226702..2226998 Escherichia coli IAI1 7126842 YP_002387564.1 CDS yegQ NC_011741.1 2227101 2228462 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 2227101..2228462 Escherichia coli IAI1 7126843 YP_002387565.1 CDS ECIAI1_2161 NC_011741.1 2228655 2228804 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2228655..2228804) Escherichia coli IAI1 7124656 YP_002387566.1 CDS yegR NC_011741.1 2228792 2229109 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2228792..2229109) Escherichia coli IAI1 7126844 YP_002387567.1 CDS yegS NC_011741.1 2229515 2230414 D cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase 2229515..2230414 Escherichia coli IAI1 7125257 YP_002387568.1 CDS gatR NC_011741.1 2230496 2231275 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7772602; Product type r : regulator; Galactitol utilization operon repressor complement(2230496..2231275) Escherichia coli IAI1 7125258 YP_002387569.1 CDS gatD NC_011741.1 2231375 2232415 R Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase complement(2231375..2232415) Escherichia coli IAI1 7128288 YP_002387570.1 CDS gatC NC_011741.1 2232463 2233818 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76024805, 77192083, 97113438, 7772602; Product type t : transporter; galactitol-specific PTS system transporter subunit IIC complement(2232463..2233818) Escherichia coli IAI1 7128287 YP_002387571.1 CDS gatB NC_011741.1 2233822 2234106 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIB complement(2233822..2234106) Escherichia coli IAI1 7128286 YP_002387572.1 CDS gatA NC_011741.1 2234137 2234589 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIA complement(2234137..2234589) Escherichia coli IAI1 7128285 YP_002387573.1 CDS gatZ NC_011741.1 2234599 2235861 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976750, 97113438, 7772602, 8932697; Product type e : enzyme; D-tagatose 1,6-bisphosphate aldolase 2 subunit complement(2234599..2235861) Escherichia coli IAI1 7128284 YP_002387574.1 CDS gatY NC_011741.1 2235890 2236744 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase complement(2235890..2236744) Escherichia coli IAI1 7128290 YP_002387575.1 CDS fbaB NC_011741.1 2237054 2238106 R catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase complement(2237054..2238106) Escherichia coli IAI1 7128289 YP_002387576.1 CDS yegT NC_011741.1 2238363 2239640 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative hydrophilic substrate MFS superfamily transporter 2238363..2239640 Escherichia coli IAI1 7127069 YP_002387577.1 CDS yegU NC_011741.1 2239637 2240641 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative (phospho)hydrolase 2239637..2240641 Escherichia coli IAI1 7125259 YP_002387578.1 CDS yegV NC_011741.1 2240638 2241603 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative kinase 2240638..2241603 Escherichia coli IAI1 7125260 YP_002387579.1 CDS yegW NC_011741.1 2241577 2242323 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(2241577..2242323) Escherichia coli IAI1 7125261 YP_002387580.1 CDS yegX NC_011741.1 2242375 2243193 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-bound hydrolase complement(2242375..2243193) Escherichia coli IAI1 7125262 YP_002387581.1 CDS thiD NC_011741.1 2243258 2244058 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(2243258..2244058) Escherichia coli IAI1 7125263 YP_002387582.1 CDS thiM NC_011741.1 2244055 2244843 R catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase complement(2244055..2244843) Escherichia coli IAI1 7126241 YP_002387583.1 CDS yohL NC_011741.1 2245066 2245338 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2245066..2245338) Escherichia coli IAI1 7125495 YP_002387584.1 CDS rncA NC_011741.1 2245459 2246283 D membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA 2245459..2246283 Escherichia coli IAI1 7127609 YP_002387585.1 CDS yohN NC_011741.1 2246322 2246840 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2246322..2246840 Escherichia coli IAI1 7125018 YP_002387586.1 CDS yehA NC_011741.1 2246922 2247956 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative exported fimbrial-like adhesin protein complement(2246922..2247956) Escherichia coli IAI1 7127610 YP_002387587.1 CDS yehB NC_011741.1 2247970 2250450 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2247970..2250450) Escherichia coli IAI1 7125264 YP_002387588.1 CDS yehC NC_011741.1 2250466 2251140 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative membrane-associated pilin chaperone complement(2250466..2251140) Escherichia coli IAI1 7125265 YP_002387589.1 CDS yehD NC_011741.1 2251221 2251763 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein complement(2251221..2251763) Escherichia coli IAI1 7125266 YP_002387590.1 CDS yehE NC_011741.1 2252056 2252337 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2252056..2252337) Escherichia coli IAI1 7125267 YP_002387591.1 CDS mrp NC_011741.1 2252600 2253709 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91080852, 15601724, 2259334; Product type t : transporter; putative ATPase complement(2252600..2253709) Escherichia coli IAI1 7125106 YP_002387592.1 CDS metG NC_011741.1 2253841 2255874 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 2253841..2255874 Escherichia coli IAI1 7124477 YP_002387593.1 CDS ECIAI1_2190 NC_011741.1 2256015 2259809 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2156810; Product type pr : putative regulator; putative Molybdate metabolism regulator (molR) 2256015..2259809 Escherichia coli IAI1 7124247 YP_002387594.1 CDS yehI NC_011741.1 2259819 2263451 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2259819..2263451 Escherichia coli IAI1 7126845 YP_002387595.1 CDS yehK NC_011741.1 2263512 2263832 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2263512..2263832 Escherichia coli IAI1 7125108 YP_002387596.1 CDS yehL NC_011741.1 2265015 2266103 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16428726; Product type pf : putative factor; putative ABC superfamily protein 2265015..2266103 Escherichia coli IAI1 7125109 YP_002387597.1 CDS yehM NC_011741.1 2266114 2268393 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2266114..2268393 Escherichia coli IAI1 7125110 YP_002387598.1 CDS yehP NC_011741.1 2268386 2269522 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2268386..2269522 Escherichia coli IAI1 7125111 YP_002387599.1 CDS yehQ NC_011741.1 2269495 2271519 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2269495..2271519 Escherichia coli IAI1 7125112 YP_002387600.1 CDS yehR NC_011741.1 2271644 2272105 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type lp : lipoprotein; hypothetical protein 2271644..2272105 Escherichia coli IAI1 7125113 YP_002387601.1 CDS yehS NC_011741.1 2272146 2272616 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2272146..2272616) Escherichia coli IAI1 7125114 YP_002387602.1 CDS yehT NC_011741.1 2272663 2273382 R unknown function; when overproduced it confers drug-resistance; putative two-component response-regulatory protein YehT complement(2272663..2273382) Escherichia coli IAI1 7125115 YP_002387603.1 CDS yehU NC_011741.1 2273379 2275064 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15522865, 15322361; Product type rc : receptor; sensory kinase in two-component system with YehT complement(2273379..2275064) Escherichia coli IAI1 7125116 YP_002387604.1 CDS mlrA NC_011741.1 2275286 2276017 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11489123; Product type r : regulator; DNA-binding transcriptional regulator 2275286..2276017 Escherichia coli IAI1 7125117 YP_002387605.1 CDS ECIAI1_2204 NC_011741.1 2276014 2276205 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(2276014..2276205) Escherichia coli IAI1 7124280 YP_002387606.1 CDS yohO NC_011741.1 2276077 2276184 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2276077..2276184 Escherichia coli IAI1 7126846 YP_002387607.1 CDS yehW NC_011741.1 2276165 2276896 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease complement(2276165..2276896) Escherichia coli IAI1 7127611 YP_002387608.1 CDS yehX NC_011741.1 2276901 2277827 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein complement(2276901..2277827) Escherichia coli IAI1 7125118 YP_002387609.1 CDS yehY NC_011741.1 2277820 2278977 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease complement(2277820..2278977) Escherichia coli IAI1 7125119 YP_002387610.1 CDS yehZ NC_011741.1 2278984 2279901 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15251200; Product type pt : putative transporter; putative ABC transporter periplasmic-binding protein complement(2278984..2279901) Escherichia coli IAI1 7125120 YP_002387611.1 CDS bglX NC_011741.1 2280112 2282409 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96303506; Product type e : enzyme; beta-D-glucoside glucohydrolase, periplasmic complement(2280112..2282409) Escherichia coli IAI1 7125121 YP_002387612.1 CDS dld NC_011741.1 2282605 2284320 D component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 2282605..2284320 Escherichia coli IAI1 7124406 YP_002387613.1 CDS pbpG NC_011741.1 2284358 2285290 R specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase complement(2284358..2285290) Escherichia coli IAI1 7124599 YP_002387614.1 CDS yohC NC_011741.1 2285464 2286051 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2285464..2286051) Escherichia coli IAI1 7124158 YP_002387615.1 CDS yohD NC_011741.1 2286221 2286799 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2286221..2286799 Escherichia coli IAI1 7127603 YP_002387616.1 CDS yohF NC_011741.1 2286929 2287690 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; acetoin dehydrogenase complement(2286929..2287690) Escherichia coli IAI1 7127604 YP_002387617.1 CDS yohG NC_011741.1 2287743 2288831 R may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance outer membrane protein MdtQ complement(2287743..2288831) Escherichia coli IAI1 7127605 YP_002387618.1 CDS dusC NC_011741.1 2289859 2290806 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566; Product type e : enzyme; tRNA-dihydrouridine synthase C complement(2289859..2290806) Escherichia coli IAI1 7127606 YP_002387619.1 CDS yohJ NC_011741.1 2291045 2291443 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2291045..2291443 Escherichia coli IAI1 7125033 YP_002387620.1 CDS yohK NC_011741.1 2291440 2292135 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2291440..2292135 Escherichia coli IAI1 7127607 YP_002387621.1 CDS cdd NC_011741.1 2292265 2293149 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2292265..2293149 Escherichia coli IAI1 7127608 YP_002387622.1 CDS sanA NC_011741.1 2293299 2294018 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 96125233, 1567863, 8550448; hypothetical protein 2293299..2294018 Escherichia coli IAI1 7126295 YP_002387623.1 CDS yeiS NC_011741.1 2294021 2294260 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2294021..2294260 Escherichia coli IAI1 7124669 YP_002387624.1 CDS yeiT NC_011741.1 2294579 2295817 D function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; putative oxidoreductase 2294579..2295817 Escherichia coli IAI1 7125134 YP_002387625.1 CDS yeiA NC_011741.1 2295811 2297046 D catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines; dihydropyrimidine dehydrogenase 2295811..2297046 Escherichia coli IAI1 7125135 YP_002387626.1 CDS mglC NC_011741.1 2297117 2298127 R ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane component complement(2297117..2298127) Escherichia coli IAI1 7125122 YP_002387627.1 CDS mglA NC_011741.1 2298143 2299663 R with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein complement(2298143..2299663) Escherichia coli IAI1 7124259 YP_002387628.1 CDS mglB NC_011741.1 2299724 2300722 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87286407, 92049246, 1719366, 3057628, 3302609, 3600760, 6340108, 6885805, 7012152, 9298646; Product type t : transporter; methyl-galactoside ABC transporter periplasmic-binding protein complement(2299724..2300722) Escherichia coli IAI1 7124257 YP_002387629.1 CDS galS NC_011741.1 2301002 2302042 R negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS complement(2301002..2302042) Escherichia coli IAI1 7124258 YP_002387630.1 CDS ECIAI1_2229 NC_011741.1 2302032 2302235 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2302032..2302235 Escherichia coli IAI1 7128274 YP_002387631.1 CDS yeiB NC_011741.1 2302184 2303341 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2302184..2303341) Escherichia coli IAI1 7126847 YP_002387632.1 CDS folE NC_011741.1 2303358 2304026 R involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I complement(2303358..2304026) Escherichia coli IAI1 7125123 YP_002387633.1 CDS ECIAI1_2232 NC_011741.1 2304180 2304356 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2304180..2304356 Escherichia coli IAI1 7127263 YP_002387634.1 CDS frmC NC_011741.1 2304284 2305120 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16567800; Product type e : enzyme; S-formylglutathione hydrolase 2304284..2305120 Escherichia coli IAI1 7126848 YP_002387635.1 CDS cirA NC_011741.1 2305152 2307143 R Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein; colicin I receptor complement(2305152..2307143) Escherichia coli IAI1 7127282 YP_002387636.1 CDS ECIAI1_2235 NC_011741.1 2307136 2307339 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2307136..2307339) Escherichia coli IAI1 7126319 YP_002387637.1 CDS lysP NC_011741.1 2307436 2308905 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92250419, 94252996, 1315732, 7551055; Product type t : transporter; lysine transporter complement(2307436..2308905) Escherichia coli IAI1 7127287 YP_002387638.1 CDS yeiE NC_011741.1 2309110 2309991 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12400704, 1315732; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(2309110..2309991) Escherichia coli IAI1 7127644 YP_002387639.1 CDS yeiH NC_011741.1 2310090 2311139 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2310090..2311139 Escherichia coli IAI1 7125125 YP_002387640.1 CDS nfo NC_011741.1 2311213 2312070 D Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2311213..2312070 Escherichia coli IAI1 7125126 YP_002387641.1 CDS yeiI NC_011741.1 2312074 2313162 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2312074..2313162 Escherichia coli IAI1 7127869 YP_002387642.1 CDS yeiJ NC_011741.1 2313218 2314468 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sodium/proton nucleoside transporter complement(2313218..2314468) Escherichia coli IAI1 7125127 YP_002387643.1 CDS rihB NC_011741.1 2314568 2315509 R Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 complement(2314568..2315509) Escherichia coli IAI1 7125128 YP_002387644.1 CDS yeiL NC_011741.1 2315678 2316337 D activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 2315678..2316337 Escherichia coli IAI1 7124999 YP_002387645.1 CDS yeiM NC_011741.1 2316408 2317658 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sodium/proton nucleoside transporter complement(2316408..2317658) Escherichia coli IAI1 7125129 YP_002387646.1 CDS yeiN NC_011741.1 2317752 2318690 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2317752..2318690) Escherichia coli IAI1 7125130 YP_002387647.1 CDS yeiC NC_011741.1 2318678 2319619 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(2318678..2319619) Escherichia coli IAI1 7125131 YP_002387648.1 CDS fruA NC_011741.1 2320043 2321734 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunits IIBC complement(2320043..2321734) Escherichia coli IAI1 7125124 YP_002387649.1 CDS fruK NC_011741.1 2321751 2322689 R converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase complement(2321751..2322689) Escherichia coli IAI1 7127286 YP_002387650.1 CDS fruB NC_011741.1 2322689 2323819 R phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein complement(2322689..2323819) Escherichia coli IAI1 7128219 YP_002387651.1 CDS ECIAI1_2250 NC_011741.1 2323850 2323993 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2323850..2323993) Escherichia coli IAI1 7128218 YP_002387652.1 CDS setB NC_011741.1 2324187 2325368 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438463, 10209755; Product type t : transporter; lactose/glucose efflux system 2324187..2325368 Escherichia coli IAI1 7127695 YP_002387653.1 CDS ECIAI1_2252 NC_011741.1 2325365 2325751 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2325365..2325751) Escherichia coli IAI1 7127913 YP_002387654.1 CDS ECIAI1_2253 NC_011741.1 2325519 2326346 D Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 2325519..2326346 Escherichia coli IAI1 7127696 YP_002387655.1 CDS yeiQ NC_011741.1 2326569 2328035 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar dehydrogenase 2326569..2328035 Escherichia coli IAI1 7127697 YP_002387656.1 CDS yeiR NC_011741.1 2328153 2329139 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2328153..2329139 Escherichia coli IAI1 7125132 YP_002387657.1 CDS yeiU NC_011741.1 2329178 2329891 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15778224; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase 2329178..2329891 Escherichia coli IAI1 7125133 YP_002387658.1 CDS spr NC_011741.1 2330303 2330869 D by similarity, Spr seems to have peptidase activity; involved in thermoresistance; putative outer membrane lipoprotein 2330303..2330869 Escherichia coli IAI1 7125136 YP_002387659.1 CDS rtn NC_011741.1 2331050 2332606 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2331050..2332606 Escherichia coli IAI1 7127964 YP_002387660.1 CDS yejA NC_011741.1 2332688 2334502 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide ABC transporter periplasmic-binding protein 2332688..2334502 Escherichia coli IAI1 7124631 YP_002387661.1 CDS yejB NC_011741.1 2334503 2335597 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide ABC transporter permease 2334503..2335597 Escherichia coli IAI1 7125137 YP_002387662.1 CDS yejE NC_011741.1 2335597 2336622 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide ABC transporter permease 2335597..2336622 Escherichia coli IAI1 7125138 YP_002387663.1 CDS yejF NC_011741.1 2336624 2338213 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative fused oligopeptideABC transporter ATP-binding protein 2336624..2338213 Escherichia coli IAI1 7125139 YP_002387664.1 CDS yejG NC_011741.1 2338217 2338561 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2338217..2338561) Escherichia coli IAI1 7125140 YP_002387665.1 CDS bcr NC_011741.1 2338893 2340083 R Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system complement(2338893..2340083) Escherichia coli IAI1 7125141 YP_002387666.1 CDS rsuA NC_011741.1 2340111 2340806 R catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A complement(2340111..2340806) Escherichia coli IAI1 7124385 YP_002387667.1 CDS yejH NC_011741.1 2340955 2342715 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleic acid ATP-dependent helicase 2340955..2342715 Escherichia coli IAI1 7128446 YP_002387668.1 CDS rplY NC_011741.1 2342840 2343124 D the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 2342840..2343124 Escherichia coli IAI1 7125142 YP_002387669.1 CDS yejK NC_011741.1 2343263 2344270 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99296598, 10368163; Product type f : factor; nucleoid-associated protein NdpA complement(2343263..2344270) Escherichia coli IAI1 7128386 YP_002387670.1 CDS yejL NC_011741.1 2344452 2344679 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2344452..2344679 Escherichia coli IAI1 7125143 YP_002387671.1 CDS yejM NC_011741.1 2344699 2346459 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase, inner membrane-associated 2344699..2346459 Escherichia coli IAI1 7125144 YP_002387672.1 CDS ECIAI1_2271 NC_011741.1 2346589 2346750 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2346589..2346750) Escherichia coli IAI1 7127995 YP_002387673.1 CDS ECIAI1_2274 NC_011741.1 2349336 2349593 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2349336..2349593) Escherichia coli IAI1 7125147 YP_002387674.1 CDS narP NC_011741.1 2349625 2350272 D nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 2349625..2350272 Escherichia coli IAI1 7127699 YP_002387675.1 CDS ccmH NC_011741.1 2350307 2351359 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 11756453, 12196152, 87260957, 91194558, 95362656, 9914305, 7635817; Product type pe : putative enzyme; heme lyase, CcmH subunit complement(2350307..2351359) Escherichia coli IAI1 7124541 YP_002387676.1 CDS ccmG NC_011741.1 2351356 2351913 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 9716493, 9770295, 11256948, 11350062, 11843181, 7635817, 9537397; Product type e : enzyme; periplasmic thioredoxin of cytochrome c-type biogenesis complement(2351356..2351913) Escherichia coli IAI1 7126293 YP_002387677.1 CDS ccmF NC_011741.1 2351910 2353853 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 11756453, 12196152, 87260957, 8842153, 91194558, 95362656, 9716493, 7635817; Product type e : enzyme; heme lyase, CcmF subunit complement(2351910..2353853) Escherichia coli IAI1 7126292 YP_002387678.1 CDS ccmE NC_011741.1 2353850 2354329 R CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE complement(2353850..2354329) Escherichia coli IAI1 7126291 YP_002387679.1 CDS ccmD NC_011741.1 2354326 2354535 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 95362656, 9716493, 7635817; Product type f : factor; cytochrome c biogenesis protein complement(2354326..2354535) Escherichia coli IAI1 7126290 YP_002387680.1 CDS ccmC NC_011741.1 2354532 2355269 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 14532274, 21413853, 95362656, 7635817; Product type t : transporter; heme ABC transporter membrane protein complement(2354532..2355269) Escherichia coli IAI1 7126180 YP_002387681.1 CDS ccmB NC_011741.1 2355311 2355973 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 95362656, 9716493, 7635817; Product type t : transporter; heme ABC transporter membrane protein complement(2355311..2355973) Escherichia coli IAI1 7124460 YP_002387682.1 CDS ccmA NC_011741.1 2355970 2356593 R ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA complement(2355970..2356593) Escherichia coli IAI1 7124459 YP_002387683.1 CDS napC NC_011741.1 2356606 2357208 R with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC complement(2356606..2357208) Escherichia coli IAI1 7124458 YP_002387684.1 CDS napB NC_011741.1 2357218 2357667 R small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit complement(2357218..2357667) Escherichia coli IAI1 7124530 YP_002387685.1 CDS napH NC_011741.1 2357664 2358527 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component complement(2357664..2358527) Escherichia coli IAI1 7124529 YP_002387686.1 CDS napG NC_011741.1 2358514 2359209 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component complement(2358514..2359209) Escherichia coli IAI1 7124534 YP_002387687.1 CDS napA NC_011741.1 2359216 2361702 R periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit complement(2359216..2361702) Escherichia coli IAI1 7124533 YP_002387688.1 CDS napD NC_011741.1 2361699 2361962 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96228696, 99395037; Product type f : factor; assembly protein for periplasmic nitrate reductase complement(2361699..2361962) Escherichia coli IAI1 7124528 YP_002387689.1 CDS napF NC_011741.1 2361952 2362446 R Predicted role in electron transfer to the periplasmic nitrate reductase protein NapA.; ferredoxin-type protein complement(2361952..2362446) Escherichia coli IAI1 7124531 YP_002387690.1 CDS ECIAI1_2292 NC_011741.1 2362546 2362719 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2362546..2362719 Escherichia coli IAI1 7124532 YP_002387691.1 CDS eco NC_011741.1 2362854 2363342 D serine protease inhibitor, inhibits trypsin and other proteases; ecotin 2362854..2363342 Escherichia coli IAI1 7127700 YP_002387692.1 CDS mqo NC_011741.1 2363491 2365137 R malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase complement(2363491..2365137) Escherichia coli IAI1 7125045 YP_002387693.1 CDS yojI NC_011741.1 2365355 2366998 R efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane component/ATP-binding component complement(2365355..2366998) Escherichia coli IAI1 7124466 YP_002387694.1 CDS alkB NC_011741.1 2367074 2367724 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12226668, 12517444, 12862460, 14527653, 87057220, 88151899, 92017669, 3536913, 3887409, 7928996; Product type e : enzyme; oxidative demethylase complement(2367074..2367724) Escherichia coli IAI1 7124227 YP_002387695.1 CDS ada NC_011741.1 2367724 2368788 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91073391, 93272965, 94252990; Product type r : regulator; fused DNA-binding transcriptional dual regulator ; O6-methylguanine-DNA methyltransferase complement(2367724..2368788) Escherichia coli IAI1 7125744 YP_002387696.1 CDS yojL NC_011741.1 2368862 2369917 R catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE complement(2368862..2369917) Escherichia coli IAI1 7125714 YP_002387697.1 CDS ompC NC_011741.1 2370029 2371132 R allows for ions and hydrophilic solutes to cross the outer membrane; outer membrane porin protein C complement(2370029..2371132) Escherichia coli IAI1 7124308 YP_002387698.1 CDS rcsD NC_011741.1 2371870 2374542 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11758943, 12864862, 21206231, 2404948, 7984428; Product type r : regulator; phosphotransfer intermediate protein in two-component regulatory system with RcsBC 2371870..2374542 Escherichia coli IAI1 7124274 YP_002387699.1 CDS rcsB NC_011741.1 2374559 2375209 D two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 2374559..2375209 Escherichia coli IAI1 7126601 YP_002387700.1 CDS rcsC NC_011741.1 2375409 2378210 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11758943, 12864862, 14651646, 20032358, 21450811, 88227838, 90130299, 92048476, 9209051, 2404948, 8366025; Product type r : regulator; hybrid sensory kinase in two-component regulatory system with RcsB and YojN complement(2375409..2378210) Escherichia coli IAI1 7126599 YP_002387701.1 CDS yfaP NC_011741.1 2378533 2379309 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2378533..2379309) Escherichia coli IAI1 7126600 YP_002387702.1 CDS yfaQ NC_011741.1 2379314 2380963 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2379314..2380963) Escherichia coli IAI1 7125154 YP_002387703.1 CDS ECIAI1_2305 NC_011741.1 2380964 2385583 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative large extracellular alpha-helical protein complement(2380964..2385583) Escherichia coli IAI1 7125155 YP_002387704.1 CDS yfaT NC_011741.1 2385502 2386125 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2385502..2386125) Escherichia coli IAI1 7127701 YP_002387705.1 CDS yfaA NC_011741.1 2386122 2387810 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2386122..2387810) Escherichia coli IAI1 7125156 YP_002387706.1 CDS ECIAI1_2308 NC_011741.1 2387843 2387923 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2387843..2387923) Escherichia coli IAI1 7125148 YP_002387707.1 CDS gyrA NC_011741.1 2387959 2390586 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A complement(2387959..2390586) Escherichia coli IAI1 7127702 YP_002387708.1 CDS ubiG NC_011741.1 2390733 2391455 D Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2390733..2391455 Escherichia coli IAI1 7128485 YP_002387709.1 CDS yfaL NC_011741.1 2391583 2395317 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659678; Product type f : factor; adhesin complement(2391583..2395317) Escherichia coli IAI1 7125515 YP_002387710.1 CDS nrdA NC_011741.1 2396013 2398298 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2396013..2398298 Escherichia coli IAI1 7125152 YP_002387711.1 CDS nrdB NC_011741.1 2398387 2399517 D B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 2398387..2399517 Escherichia coli IAI1 7127900 YP_002387712.1 CDS yfaE NC_011741.1 2399517 2399771 D plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin YfaE 2399517..2399771 Escherichia coli IAI1 7127901 YP_002387713.1 CDS inaA NC_011741.1 2399825 2400475 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 92165728, 1537798, 6087316; hypothetical protein complement(2399825..2400475) Escherichia coli IAI1 7125150 YP_002387714.1 CDS yfaH NC_011741.1 2400690 2400896 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2400690..2400896 Escherichia coli IAI1 7126063 YP_002387715.1 CDS glpQ NC_011741.1 2400938 2402014 R hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase complement(2400938..2402014) Escherichia coli IAI1 7125151 YP_002387716.1 CDS glpT NC_011741.1 2402019 2403377 R catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter complement(2402019..2403377) Escherichia coli IAI1 7128342 YP_002387717.1 CDS glpA NC_011741.1 2403650 2405278 D anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 2403650..2405278 Escherichia coli IAI1 7128344 YP_002387718.1 CDS glpB NC_011741.1 2405268 2406527 D sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 2405268..2406527 Escherichia coli IAI1 7128334 YP_002387719.1 CDS glpC NC_011741.1 2406524 2407714 D anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 2406524..2407714 Escherichia coli IAI1 7128335 YP_002387720.1 CDS yfaD NC_011741.1 2407908 2408810 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2407908..2408810 Escherichia coli IAI1 7128336 YP_002387721.1 CDS yfaY NC_011741.1 2409376 2410578 R Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A complement(2409376..2410578) Escherichia coli IAI1 7125157 YP_002387722.1 CDS yfaZ NC_011741.1 2410678 2411220 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane porin protein complement(2410678..2411220) Escherichia coli IAI1 7125158 YP_002387723.1 CDS yfaO NC_011741.1 2411499 2411924 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16430214; Product type pe : putative enzyme; putative NUDIX hydrolase 2411499..2411924 Escherichia coli IAI1 7125159 YP_002387724.1 CDS ais NC_011741.1 2411963 2412565 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2411963..2412565) Escherichia coli IAI1 7125153 YP_002387725.1 CDS yfbE NC_011741.1 2412855 2414012 D catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 2412855..2414012 Escherichia coli IAI1 7125739 YP_002387726.1 CDS yfbF NC_011741.1 2414016 2414984 D catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 2414016..2414984 Escherichia coli IAI1 7125161 YP_002387727.1 CDS yfbG NC_011741.1 2414984 2416966 D Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 2414984..2416966 Escherichia coli IAI1 7125162 YP_002387728.1 CDS yfbH NC_011741.1 2416963 2417853 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2416963..2417853 Escherichia coli IAI1 7125163 YP_002387729.1 CDS arnT NC_011741.1 2417853 2419505 D catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 2417853..2419505 Escherichia coli IAI1 7125164 YP_002387730.1 CDS yfbW NC_011741.1 2419502 2419837 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2419502..2419837 Escherichia coli IAI1 7125801 YP_002387731.1 CDS yfbJ NC_011741.1 2419555 2420223 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2419555..2420223 Escherichia coli IAI1 7125173 YP_002387732.1 CDS pmrD NC_011741.1 2420217 2420483 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96015440, 15569938; Product type pt : putative transporter; polymyxin resistance protein B complement(2420217..2420483) Escherichia coli IAI1 7125165 YP_002387733.1 CDS menE NC_011741.1 2420593 2421948 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96186953, 8626063; Product type e : enzyme; O-succinylbenzoic acid--CoA ligase complement(2420593..2421948) Escherichia coli IAI1 7126104 YP_002387734.1 CDS menC NC_011741.1 2421945 2422907 R catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase complement(2421945..2422907) Escherichia coli IAI1 7124239 YP_002387735.1 CDS menB NC_011741.1 2422907 2423764 R catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase complement(2422907..2423764) Escherichia coli IAI1 7124237 YP_002387736.1 CDS yfbB NC_011741.1 2423779 2424537 R catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase YfbB complement(2423779..2424537) Escherichia coli IAI1 7124236 YP_002387737.1 CDS menD NC_011741.1 2424534 2426204 R SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase complement(2424534..2426204) Escherichia coli IAI1 7125160 YP_002387738.1 CDS menF NC_011741.1 2426293 2427588 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150206, 96140724, 2666397, 7984428, 8549818, 8764478; Product type e : enzyme; isochorismate synthase 2 complement(2426293..2427588) Escherichia coli IAI1 7124238 YP_002387739.1 CDS elaB NC_011741.1 2427667 2427972 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2427667..2427972) Escherichia coli IAI1 7124240 YP_002387740.1 CDS elaA NC_011741.1 2428027 2428488 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(2428027..2428488) Escherichia coli IAI1 7125056 YP_002387741.1 CDS elaC NC_011741.1 2428553 2429470 D member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2428553..2429470 Escherichia coli IAI1 7125055 YP_002387742.1 CDS elaD NC_011741.1 2429658 2430878 D ElaD; specific cysteine protease which targets ubiquitin and ubiquitin-like proteins covalently bound to target proteins; SseL in Salmonella is required for macrophage killing and virulence, and it is secreted by the salmonella pathogenicity island 2 type III secretion system; deubiquitinase 2429658..2430878 Escherichia coli IAI1 7125057 YP_002387743.1 CDS ECIAI1_2348 NC_011741.1 2431523 2431873 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2431523..2431873 Escherichia coli IAI1 7125058 YP_002387744.1 CDS yfbM NC_011741.1 2431999 2432502 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2431999..2432502 Escherichia coli IAI1 7127703 YP_002387745.1 CDS nuoN NC_011741.1 2432569 2434026 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N complement(2432569..2434026) Escherichia coli IAI1 7125166 YP_002387746.1 CDS nuoM NC_011741.1 2434033 2435562 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M complement(2434033..2435562) Escherichia coli IAI1 7125970 YP_002387747.1 CDS nuoL NC_011741.1 2435726 2437567 R Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L complement(2435726..2437567) Escherichia coli IAI1 7125969 YP_002387748.1 CDS nuoK NC_011741.1 2437564 2437866 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K complement(2437564..2437866) Escherichia coli IAI1 7125968 YP_002387749.1 CDS nuoJ NC_011741.1 2437863 2438417 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J complement(2437863..2438417) Escherichia coli IAI1 7125967 YP_002387750.1 CDS nuoI NC_011741.1 2438429 2438971 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I complement(2438429..2438971) Escherichia coli IAI1 7125966 YP_002387751.1 CDS nuoH NC_011741.1 2438986 2439963 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H complement(2438986..2439963) Escherichia coli IAI1 7125965 YP_002387752.1 CDS nuoG NC_011741.1 2439960 2442692 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G complement(2439960..2442692) Escherichia coli IAI1 7125964 YP_002387753.1 CDS nuoF NC_011741.1 2442739 2444076 R shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F complement(2442739..2444076) Escherichia coli IAI1 7125963 YP_002387754.1 CDS nuoE NC_011741.1 2444073 2444573 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E complement(2444073..2444573) Escherichia coli IAI1 7125962 YP_002387755.1 CDS nuoC NC_011741.1 2444576 2446378 R NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D complement(2444576..2446378) Escherichia coli IAI1 7125961 YP_002387756.1 CDS nuoB NC_011741.1 2446472 2447134 R The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B complement(2446472..2447134) Escherichia coli IAI1 7125960 YP_002387757.1 CDS nuoA NC_011741.1 2447150 2447593 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A complement(2447150..2447593) Escherichia coli IAI1 7125959 YP_002387758.1 CDS lrhA NC_011741.1 2448224 2449162 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123461, 9882671, 7565112; Product type r : regulator; DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes complement(2448224..2449162) Escherichia coli IAI1 7125958 YP_002387759.1 CDS yfbQ NC_011741.1 2450082 2451299 D broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 2450082..2451299 Escherichia coli IAI1 7127630 YP_002387760.1 CDS yfbR NC_011741.1 2451383 2451982 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15489502; Product type e : enzyme; hypothetical protein 2451383..2451982 Escherichia coli IAI1 7125167 YP_002387761.1 CDS yfbS NC_011741.1 2452041 2453873 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(2452041..2453873) Escherichia coli IAI1 7125168 YP_002387762.1 CDS yfbT NC_011741.1 2453960 2454610 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphatase complement(2453960..2454610) Escherichia coli IAI1 7125169 YP_002387763.1 CDS yfbU NC_011741.1 2454621 2455115 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2454621..2455115) Escherichia coli IAI1 7125170 YP_002387764.1 CDS yfbV NC_011741.1 2455198 2455653 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2455198..2455653) Escherichia coli IAI1 7125171 YP_002387765.1 CDS ECIAI1_2370 NC_011741.1 2455821 2455982 D hypothetical protein 2455821..2455982 Escherichia coli IAI1 7125172 YP_002387766.1 CDS ackA NC_011741.1 2455991 2457193 D AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2455991..2457193 Escherichia coli IAI1 7127704 YP_002387767.1 CDS pta NC_011741.1 2457268 2459412 D catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 2457268..2459412 Escherichia coli IAI1 7125699 YP_002387768.1 CDS yfcD NC_011741.1 2461154 2461696 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16430214; Product type pe : putative enzyme; putative NUDIX hydrolase complement(2461154..2461696) Escherichia coli IAI1 7125176 YP_002387769.1 CDS yfcE NC_011741.1 2461754 2462308 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; phosphodiesterase complement(2461754..2462308) Escherichia coli IAI1 7125177 YP_002387770.1 CDS yfcF NC_011741.1 2462361 2463005 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(2462361..2463005) Escherichia coli IAI1 7125178 YP_002387771.1 CDS yfcG NC_011741.1 2463141 2463788 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; glutathione S-transferase 2463141..2463788 Escherichia coli IAI1 7125179 YP_002387772.1 CDS folX NC_011741.1 2463845 2464207 D catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 2463845..2464207 Escherichia coli IAI1 7125180 YP_002387773.1 CDS yfcH NC_011741.1 2464228 2465121 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : putative enzyme; hypothetical protein 2464228..2465121 Escherichia coli IAI1 7127267 YP_002387774.1 CDS yfcI NC_011741.1 2465169 2466071 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase complement(2465169..2466071) Escherichia coli IAI1 7125181 YP_002387775.1 CDS hisP NC_011741.1 2466268 2467041 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 3313284, 91060556; Product type t : transporter; histidine/lysine/arginine/ornithine transporter subunit complement(2466268..2467041) Escherichia coli IAI1 7125182 YP_002387776.1 CDS hisM NC_011741.1 2467049 2467765 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 3313284; Product type t : transporter; histidine/lysine/arginine/ornithine ABC transporter membrane protein complement(2467049..2467765) Escherichia coli IAI1 7125279 YP_002387777.1 CDS hisQ NC_011741.1 2467762 2468448 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434; Product type t : transporter; histidine/lysine/arginine/ornithine ABC transporter membrane protein complement(2467762..2468448) Escherichia coli IAI1 7125278 YP_002387778.1 CDS hisJ NC_011741.1 2468538 2469320 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 6449635, 8161536, 9298646, 9600841, 9740056; Product type t : transporter; histidine/lysine/arginine/ornithine ABC transporter periplasmic-binding protein complement(2468538..2469320) Escherichia coli IAI1 7125280 YP_002387779.1 CDS ubiX NC_011741.1 2470589 2471158 R catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase complement(2470589..2471158) Escherichia coli IAI1 7125800 YP_002387780.1 CDS purF NC_011741.1 2471253 2472770 R Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase complement(2471253..2472770) Escherichia coli IAI1 7125517 YP_002387781.1 CDS cvpA NC_011741.1 2472807 2473295 R membrane protein required for colicin V production; colicin V production protein complement(2472807..2473295) Escherichia coli IAI1 7126549 YP_002387782.1 CDS dedD NC_011741.1 2473554 2474216 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3040734; hypothetical protein complement(2473554..2474216) Escherichia coli IAI1 7126867 YP_002387783.1 CDS folC NC_011741.1 2474206 2475474 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3040739, 91112811, 92041808, 1989505, 3040734; Product type e : enzyme; bifunctional folylpolyglutamate synthase/ dihydrofolate synthase complement(2474206..2475474) Escherichia coli IAI1 7124558 YP_002387784.1 CDS accD NC_011741.1 2475544 2476458 R catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta complement(2475544..2476458) Escherichia coli IAI1 7127261 YP_002387785.1 CDS dedA NC_011741.1 2476614 2477273 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3029016, 3040734, 7678242; Product type pm : putative membrane component; hypothetical protein complement(2476614..2477273) Escherichia coli IAI1 7125693 YP_002387786.1 CDS truA NC_011741.1 2477356 2478168 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(2477356..2478168) Escherichia coli IAI1 7124557 YP_002387787.1 CDS usg NC_011741.1 2478168 2479181 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 92380957, 92380982, 93123150, 2681152, 2991861, 3029016; Product type pe : putative enzyme; putative semialdehyde dehydrogenase complement(2478168..2479181) Escherichia coli IAI1 7127502 YP_002387788.1 CDS pdxB NC_011741.1 2479247 2480383 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90036695, 91035267, 2681152, 2991861, 3029016; Product type e : enzyme; erythronate-4-phosphate dehydrogenase complement(2479247..2480383) Escherichia coli IAI1 7125548 YP_002387789.1 CDS flk NC_011741.1 2480482 2481477 D in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 2480482..2481477 Escherichia coli IAI1 7124164 YP_002387790.1 CDS yfcJ NC_011741.1 2481474 2482652 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein complement(2481474..2482652) Escherichia coli IAI1 7127252 YP_002387791.1 CDS fabB NC_011741.1 2482936 2484156 R FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase I complement(2482936..2484156) Escherichia coli IAI1 7125183 YP_002387792.1 CDS mnmC NC_011741.1 2484315 2486321 D catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 2484315..2486321 Escherichia coli IAI1 7127053 YP_002387793.1 CDS yfcL NC_011741.1 2486442 2486720 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2486442..2486720) Escherichia coli IAI1 7127489 YP_002387794.1 CDS yfcM NC_011741.1 2486754 2487302 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2486754..2487302) Escherichia coli IAI1 7125184 YP_002387795.1 CDS yfcA NC_011741.1 2487302 2488111 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2487302..2488111) Escherichia coli IAI1 7125185 YP_002387796.1 CDS mepA NC_011741.1 2488111 2488935 R D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase complement(2488111..2488935) Escherichia coli IAI1 7125174 YP_002387797.1 CDS aroC NC_011741.1 2488939 2490024 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(2488939..2490024) Escherichia coli IAI1 7124241 YP_002387798.1 CDS prmB NC_011741.1 2490059 2490991 R involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase complement(2490059..2490991) Escherichia coli IAI1 7125804 YP_002387799.1 CDS yfcN NC_011741.1 2491157 2491708 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2491157..2491708 Escherichia coli IAI1 7126154 YP_002387800.1 CDS ECIAI1_2409 NC_011741.1 2491903 2492883 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family complement(2491903..2492883) Escherichia coli IAI1 7125186 YP_002387801.1 CDS ECIAI1_2410 NC_011741.1 2493110 2493982 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2493110..2493982) Escherichia coli IAI1 7127712 YP_002387802.1 CDS ECIAI1_2411 NC_011741.1 2493969 2494493 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial protein (Adhesin) complement(2493969..2494493) Escherichia coli IAI1 7127713 YP_002387803.1 CDS ECIAI1_2412 NC_011741.1 2494490 2494960 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial protein complement(2494490..2494960) Escherichia coli IAI1 7127714 YP_002387804.1 CDS ECIAI1_2413 NC_011741.1 2494957 2495571 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative minor fimbrial subunit complement(2494957..2495571) Escherichia coli IAI1 7127715 YP_002387805.1 CDS yfcS NC_011741.1 2495480 2496232 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative periplasmic pilus exported chaperone complement(2495480..2496232) Escherichia coli IAI1 7127716 YP_002387806.1 CDS ECIAI1_2415 NC_011741.1 2496252 2498894 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane usher protein yfcU complement(2496252..2498894) Escherichia coli IAI1 7125187 YP_002387807.1 CDS yfcV NC_011741.1 2498976 2499539 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein complement(2498976..2499539) Escherichia coli IAI1 7127717 YP_002387808.1 CDS sixA NC_011741.1 2500223 2500708 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10089421, 20200300, 9489669; Product type e : enzyme; phosphohistidine phosphatase complement(2500223..2500708) Escherichia coli IAI1 7128702 YP_002387809.1 CDS fadJ NC_011741.1 2500911 2503055 R multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha complement(2500911..2503055) Escherichia coli IAI1 7127929 YP_002387810.1 CDS fadI NC_011741.1 2503055 2504365 R FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase complement(2503055..2504365) Escherichia coli IAI1 7125832 YP_002387811.1 CDS yfcZ NC_011741.1 2504545 2504829 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2504545..2504829) Escherichia coli IAI1 7125833 YP_002387812.1 CDS fadL NC_011741.1 2505195 2506541 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15178802, 2840553, 3286621, 91100327, 1987139, 9119048; Product type t : transporter; long-chain fatty acid outer membrane transporter 2505195..2506541 Escherichia coli IAI1 7125834 YP_002387813.1 CDS yfdF NC_011741.1 2506907 2507965 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2506907..2507965 Escherichia coli IAI1 7127066 YP_002387814.1 CDS vacJ NC_011741.1 2508147 2508902 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8145644, 15352239; Product type lp : lipoprotein; hypothetical protein complement(2508147..2508902) Escherichia coli IAI1 7125837 YP_002387815.1 CDS ECIAI1_2424 NC_011741.1 2508928 2509098 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2508928..2509098) Escherichia coli IAI1 7125566 YP_002387816.1 CDS yfdC NC_011741.1 2509196 2510128 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2509196..2510128 Escherichia coli IAI1 7127718 YP_002387817.1 CDS lacY NC_011741.1 2510720 2511967 R lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease complement(2510720..2511967) Escherichia coli IAI1 7127996 YP_002387818.1 CDS cscK NC_011741.1 2512039 2512953 R phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least; aminoimidazole riboside kinase complement(2512039..2512953) Escherichia coli IAI1 7125918 YP_002387819.1 CDS cscA NC_011741.1 2513160 2514602 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12218016; Product type e : enzyme; Sucrose-6-phosphate hydrolase 2513160..2514602 Escherichia coli IAI1 7125919 YP_002387820.1 CDS cscR NC_011741.1 2514610 2515791 R Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Sucrose operon repressor complement(2514610..2515791) Escherichia coli IAI1 7125917 YP_002387821.1 CDS dsdA NC_011741.1 2516072 2517400 D catalyzes the formation of pyruvate from serine; D-serine dehydratase 2516072..2517400 Escherichia coli IAI1 7125027 YP_002387822.1 CDS emrY NC_011741.1 2517508 2519046 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20378313; Product type pt : putative transporter; putative multidrug efflux system complement(2517508..2519046) Escherichia coli IAI1 7125026 YP_002387823.1 CDS emrK NC_011741.1 2519046 2520209 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20378313; Product type t : transporter; EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component complement(2519046..2520209) Escherichia coli IAI1 7125064 YP_002387824.1 CDS evgA NC_011741.1 2520625 2521239 D response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; DNA-binding transcriptional activator EvgA 2520625..2521239 Escherichia coli IAI1 7125063 YP_002387825.1 CDS evgS NC_011741.1 2521244 2524837 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14523115, 93173621, 9501520, 10923791, 1289796, 8125343, 9535079; Product type r : regulator; hybrid sensory histidine kinase in two-component regulatory system with EvgA 2521244..2524837 Escherichia coli IAI1 7125105 YP_002387826.1 CDS yfdE NC_011741.1 2524893 2526038 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(2524893..2526038) Escherichia coli IAI1 7128609 YP_002387827.1 CDS yfdV NC_011741.1 2526112 2527056 R member of the AEC family of auxin efflux transporters; unknown function; putative transporter YfdV complement(2526112..2527056) Escherichia coli IAI1 7125836 YP_002387828.1 CDS oxc NC_011741.1 2527126 2528820 R catalyzes the formation of formyl-CoA from oxalyl-CoA; putative oxalyl-CoA decarboxylase complement(2527126..2528820) Escherichia coli IAI1 7125838 YP_002387829.1 CDS frc NC_011741.1 2528874 2530124 R catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase complement(2528874..2530124) Escherichia coli IAI1 7126001 YP_002387830.1 CDS yfdX NC_011741.1 2530637 2531269 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11157960; hypothetical protein complement(2530637..2531269) Escherichia coli IAI1 7127269 YP_002387831.1 CDS ypdI NC_011741.1 2531603 2531878 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15183873; Product type lp : lipoprotein; hypothetical protein 2531603..2531878 Escherichia coli IAI1 7125839 YP_002387832.1 CDS yfdY NC_011741.1 2531955 2532197 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089; Product type pm : putative membrane component; hypothetical protein complement(2531955..2532197) Escherichia coli IAI1 7124317 YP_002387834.1 CDS ddg NC_011741.1 2532550 2533470 D Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 2532550..2533470 Escherichia coli IAI1 7127719 YP_002387835.1 CDS yfdZ NC_011741.1 2533962 2535200 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; aminotransferase complement(2533962..2535200) Escherichia coli IAI1 7127477 YP_002387836.1 CDS ypdA NC_011741.1 2535577 2537274 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15522865; Product type prc : putative receptor; putative sensory kinase in two-component system with YpdB 2535577..2537274 Escherichia coli IAI1 7125841 YP_002387837.1 CDS ypdB NC_011741.1 2537289 2538023 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15522865; Product type pr : putative regulator; putative response regulator in two-component system with YpdA 2537289..2538023 Escherichia coli IAI1 7124309 YP_002387838.1 CDS ypdC NC_011741.1 2538036 2538893 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding protein 2538036..2538893 Escherichia coli IAI1 7124310 YP_002387839.1 CDS ypdD NC_011741.1 2538896 2541391 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative fused PTS enzymes (multiphosphoryl transfer protein): Hpr component ; enzyme I component ; enzyme IIA component complement(2538896..2541391) Escherichia coli IAI1 7124311 YP_002387840.1 CDS ypdE NC_011741.1 2541416 2542453 R metalloprotein; exoaminopeptidase complement(2541416..2542453) Escherichia coli IAI1 7124312 YP_002387841.1 CDS ypdF NC_011741.1 2542453 2543538 R Xaa-Pro aminopeptidase; limited methionine aminopeptidase; aminopeptidase complement(2542453..2543538) Escherichia coli IAI1 7124313 YP_002387842.1 CDS ypdG NC_011741.1 2543553 2544800 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative PTS system transporter subunit IIC complement(2543553..2544800) Escherichia coli IAI1 7124314 YP_002387843.1 CDS ypdH NC_011741.1 2544822 2545148 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative PTS system transporter subunit IIB complement(2544822..2545148) Escherichia coli IAI1 7124315 YP_002387844.1 CDS glk NC_011741.1 2545368 2546333 R catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase complement(2545368..2546333) Escherichia coli IAI1 7124316 YP_002387845.1 CDS yfeO NC_011741.1 2546537 2547793 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 2546537..2547793 Escherichia coli IAI1 7128317 YP_002387846.1 CDS ypeC NC_011741.1 2547908 2548234 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2547908..2548234 Escherichia coli IAI1 7125848 YP_002387847.1 CDS mntH NC_011741.1 2548375 2549613 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20177822, 20305051, 10712688, 10844693; Product type t : transporter; manganese transport protein MntH complement(2548375..2549613) Escherichia coli IAI1 7124319 YP_002387848.1 CDS nupC NC_011741.1 2549949 2551151 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 374403, 8022285, 7007808, 827549, 4563236, 1512211; Product type t : transporter; nucleoside (except guanosine) transporter 2549949..2551151 Escherichia coli IAI1 7124288 YP_002387849.1 CDS yfeA NC_011741.1 2551201 2553390 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase complement(2551201..2553390) Escherichia coli IAI1 7125971 YP_002387850.1 CDS yfeC NC_011741.1 2554025 2554369 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative nucleic acid-binding transcriptional regulator 2554025..2554369 Escherichia coli IAI1 7128047 YP_002387851.1 CDS yfeD NC_011741.1 2554371 2554763 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative nucleic acid-binding transcriptional regulator 2554371..2554763 Escherichia coli IAI1 7125843 YP_002387852.1 CDS gltX NC_011741.1 2554815 2556230 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(2554815..2556230) Escherichia coli IAI1 7125844 YP_002387853.1 CDS ECIAI1_2465 NC_011741.1 2557162 2557503 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2557162..2557503 Escherichia coli IAI1 7128000 YP_002387854.1 CDS yfeR NC_011741.1 2557494 2558420 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(2557494..2558420) Escherichia coli IAI1 7127720 YP_002387855.1 CDS yfeH NC_011741.1 2558510 2559508 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative sodium/bile acid symporter familyprotein 2558510..2559508 Escherichia coli IAI1 7125849 YP_002387856.1 CDS ECIAI1_2468 NC_011741.1 2559505 2559822 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2559505..2559822) Escherichia coli IAI1 7125846 YP_002387857.1 CDS ligA NC_011741.1 2559725 2561740 R this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA complement(2559725..2561740) Escherichia coli IAI1 7127721 YP_002387858.1 CDS zipA NC_011741.1 2561811 2562797 R interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA complement(2561811..2562797) Escherichia coli IAI1 7126418 YP_002387859.1 CDS cysZ NC_011741.1 2563027 2563788 D putative role in sulfur assimilation; putative sulfate transport protein CysZ 2563027..2563788 Escherichia coli IAI1 7128124 YP_002387860.1 CDS cysK NC_011741.1 2563973 2564944 D CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 2563973..2564944 Escherichia coli IAI1 7126904 YP_002387861.1 CDS ptsH NC_011741.1 2565328 2565585 D Evidence 1b : Function experimentally demonstrated in the studied species; Product type t : transporter; PTS system phosphohistidinoprotein-hexose phosphotransferase subunit Hpr 2565328..2565585 Escherichia coli IAI1 7126896 YP_002387862.1 CDS ptsI NC_011741.1 2565630 2567357 D Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 2565630..2567357 Escherichia coli IAI1 7126540 YP_002387863.1 CDS crr NC_011741.1 2567398 2567907 D functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter subunit 2567398..2567907 Escherichia coli IAI1 7126541 YP_002387864.1 CDS pdxK NC_011741.1 2567949 2568800 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase complement(2567949..2568800) Escherichia coli IAI1 7125916 YP_002387865.1 CDS yfeK NC_011741.1 2568905 2569273 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2568905..2569273 Escherichia coli IAI1 7124167 YP_002387866.1 CDS cysM NC_011741.1 2569276 2570187 R catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B complement(2569276..2570187) Escherichia coli IAI1 7125847 YP_002387867.1 CDS cysA NC_011741.1 2570321 2571418 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202710, 90264334, 2188958, 7665461; Product type t : transporter; sulfate/thiosulfate transporter subunit complement(2570321..2571418) Escherichia coli IAI1 7126897 YP_002387868.1 CDS cysW NC_011741.1 2571408 2572283 R Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate transporter permease subunit complement(2571408..2572283) Escherichia coli IAI1 7126887 YP_002387869.1 CDS cysU NC_011741.1 2572283 2573116 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264334, 2188958; Product type t : transporter; sulfate/thiosulfate transporter subunit complement(2572283..2573116) Escherichia coli IAI1 7126903 YP_002387870.1 CDS cysP NC_011741.1 2573116 2574132 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264335, 2188959, 9298646; Product type t : transporter; thiosulfate transporter subunit complement(2573116..2574132) Escherichia coli IAI1 7126902 YP_002387871.1 CDS ucpA NC_011741.1 2574290 2575081 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 97385354, 2188959, 7984428, 9241368; Product type pe : putative enzyme; short chain dehydrogenase complement(2574290..2575081) Escherichia coli IAI1 7126899 YP_002387872.1 CDS yfeT NC_011741.1 2575210 2576067 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(2575210..2576067) Escherichia coli IAI1 7125518 YP_002387873.1 CDS murQ NC_011741.1 2576231 2577127 D catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid-6-phosphate etherase 2576231..2577127 Escherichia coli IAI1 7125850 YP_002387874.1 CDS murP NC_011741.1 2577131 2578555 D belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; PTS system N-acetylmuramic acid transporter subunits EIIBC 2577131..2578555 Escherichia coli IAI1 7125851 YP_002387875.1 CDS murQ NC_011741.1 2578560 2579864 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15983044, 15060041; Product type e : enzyme; hypothetical protein 2578560..2579864 Escherichia coli IAI1 7124500 YP_002387876.1 CDS yfeX NC_011741.1 2579922 2580821 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2579922..2580821) Escherichia coli IAI1 7124501 YP_002387877.1 CDS yfeY NC_011741.1 2580917 2581492 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12900013, 7764507; hypothetical protein complement(2580917..2581492) Escherichia coli IAI1 7125852 YP_002387878.1 CDS yfeZ NC_011741.1 2581553 2582002 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2581553..2582002) Escherichia coli IAI1 7125853 YP_002387879.1 CDS ypeA NC_011741.1 2581989 2582414 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase complement(2581989..2582414) Escherichia coli IAI1 7125854 YP_002387880.1 CDS amiA NC_011741.1 2582628 2583497 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21348478, 6137479, 87242501, 1903834, 8300522; Product type e : enzyme; N-acetylmuramoyl-l-alanine amidase I 2582628..2583497 Escherichia coli IAI1 7124318 YP_002387881.1 CDS hemF NC_011741.1 2583501 2584400 D catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 2583501..2584400 Escherichia coli IAI1 7125752 YP_002387882.1 CDS yfeG NC_011741.1 2584406 2585458 R activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR complement(2584406..2585458) Escherichia coli IAI1 7128510 YP_002387883.1 CDS yffI NC_011741.1 2585504 2586004 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10464203; Product type ps : putative structure; putative ethanolaminosome structural protein complement(2585504..2586004) Escherichia coli IAI1 7125845 YP_002387884.1 CDS eutL NC_011741.1 2586017 2586676 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein complement(2586017..2586676) Escherichia coli IAI1 7125857 YP_002387885.1 CDS eutC NC_011741.1 2586686 2587573 R catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit complement(2586686..2587573) Escherichia coli IAI1 7125101 YP_002387886.1 CDS eutB NC_011741.1 2587594 2588955 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3905806, 10464203; Product type e : enzyme; ethanolamine ammonia-lyase, large subunit, heavy chain complement(2587594..2588955) Escherichia coli IAI1 7125095 YP_002387887.1 CDS eutA NC_011741.1 2588967 2590370 R ethanolamine utilization protein EutA; reactivating factor for ethanolamine ammonia lyase complement(2588967..2590370) Escherichia coli IAI1 7125094 YP_002387888.1 CDS eutH NC_011741.1 2590367 2591593 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7868611, 10464203; Product type pt : putative transporter; putative ethanolamine transporter complement(2590367..2591593) Escherichia coli IAI1 7125093 YP_002387889.1 CDS eutG NC_011741.1 2591710 2592897 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative alcohol dehydrogenase complement(2591710..2592897) Escherichia coli IAI1 7125098 YP_002387890.1 CDS eutJ NC_011741.1 2592887 2593723 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pf : putative factor; putative chaperonin complement(2592887..2593723) Escherichia coli IAI1 7125097 YP_002387891.1 CDS eutE NC_011741.1 2593734 2595137 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative aldehyde dehydrogenase complement(2593734..2595137) Escherichia coli IAI1 7125100 YP_002387892.1 CDS cchB NC_011741.1 2595149 2595436 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein complement(2595149..2595436) Escherichia coli IAI1 7125096 YP_002387893.1 CDS cchA NC_011741.1 2595543 2595836 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein complement(2595543..2595836) Escherichia coli IAI1 7124457 YP_002387894.1 CDS eutD NC_011741.1 2595875 2596891 R in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase complement(2595875..2596891) Escherichia coli IAI1 7124456 YP_002387895.1 CDS eutT NC_011741.1 2596888 2597691 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative cobalamin adenosyltransferase in ethanolamine utilization complement(2596888..2597691) Escherichia coli IAI1 7125099 YP_002387896.1 CDS eutQ NC_011741.1 2597688 2598389 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10464203; hypothetical protein complement(2597688..2598389) Escherichia coli IAI1 7125104 YP_002387897.1 CDS eutP NC_011741.1 2598364 2598843 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative nucleoside triphosphate hydrolase domain-containing protein complement(2598364..2598843) Escherichia coli IAI1 7125103 YP_002387898.1 CDS ypfE NC_011741.1 2598856 2599191 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein complement(2598856..2599191) Escherichia coli IAI1 7125102 YP_002387899.1 CDS maeB NC_011741.1 2599484 2601763 R NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme complement(2599484..2601763) Escherichia coli IAI1 7124320 YP_002387900.1 CDS talA NC_011741.1 2602052 2603002 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90230300; Product type e : enzyme; transaldolase A 2602052..2603002 Escherichia coli IAI1 7127652 YP_002387901.1 CDS tktB NC_011741.1 2603022 2605025 D catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2603022..2605025 Escherichia coli IAI1 7126208 YP_002387902.1 CDS ypfG NC_011741.1 2605121 2606164 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2605121..2606164) Escherichia coli IAI1 7127452 YP_002387903.1 CDS yffH NC_011741.1 2606290 2606865 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NUDIX hydrolase complement(2606290..2606865) Escherichia coli IAI1 7124321 YP_002387904.1 CDS aegA NC_011741.1 2606933 2608912 R unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); putative oxidoreductase Fe-S binding subunit complement(2606933..2608912) Escherichia coli IAI1 7125856 YP_002387905.1 CDS narQ NC_011741.1 2609118 2610818 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92374842, 1508040, 1528845; Product type r : regulator; nitrate/nitrite sensor protein NarQ 2609118..2610818 Escherichia coli IAI1 7125724 YP_002387906.1 CDS acrD NC_011741.1 2610982 2614095 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12426336, 20158894, 21450803, 79216220, 10692383, 1644752; Product type t : transporter; aminoglycoside/multidrug efflux system 2610982..2614095 Escherichia coli IAI1 7128608 YP_002387907.1 CDS yffB NC_011741.1 2614634 2614990 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2614634..2614990 Escherichia coli IAI1 7125708 YP_002387908.1 CDS dapE NC_011741.1 2614994 2616121 D dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2614994..2616121 Escherichia coli IAI1 7125855 YP_002387909.1 CDS ypfN NC_011741.1 2616149 2616349 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2616149..2616349 Escherichia coli IAI1 7126919 YP_002387910.1 CDS ypfH NC_011741.1 2616459 2617157 R Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YpfH complement(2616459..2617157) Escherichia coli IAI1 7124325 YP_002387911.1 CDS ypfI NC_011741.1 2617231 2619246 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase complement(2617231..2619246) Escherichia coli IAI1 7124322 YP_002387912.1 CDS ypfJ NC_011741.1 2619261 2620124 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2619261..2620124) Escherichia coli IAI1 7124323 YP_002387913.1 CDS ECIAI1_2525 NC_011741.1 2620271 2620669 R stability determinant protein; plasmid maintenance protein complement(2620271..2620669) Escherichia coli IAI1 7124324 YP_002387914.1 CDS ECIAI1_2526 NC_011741.1 2620669 2620935 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2620669..2620935) Escherichia coli IAI1 7127722 YP_002387915.1 CDS purC NC_011741.1 2621051 2621764 R catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase complement(2621051..2621764) Escherichia coli IAI1 7127723 YP_002387916.1 CDS nlpB NC_011741.1 2621977 2623011 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358331, 1885529, 2120198; Product type lp : lipoprotein; lipoprotein complement(2621977..2623011) Escherichia coli IAI1 7126546 YP_002387917.1 CDS dapA NC_011741.1 2623028 2623906 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(2623028..2623906) Escherichia coli IAI1 7127888 YP_002387918.1 CDS gcvR NC_011741.1 2624052 2624624 D negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 2624052..2624624 Escherichia coli IAI1 7126916 YP_002387919.1 CDS bcp NC_011741.1 2624624 2625094 D bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 2624624..2625094 Escherichia coli IAI1 7128298 YP_002387920.1 CDS hyfA NC_011741.1 2625347 2625964 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241, 2016588; Product type c : carrier; hydrogenase 4, 4Fe-4S subunit 2625347..2625964 Escherichia coli IAI1 7124384 YP_002387921.1 CDS hyfB NC_011741.1 2625964 2627982 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4 subunit B 2625964..2627982 Escherichia coli IAI1 7126017 YP_002387922.1 CDS hyfC NC_011741.1 2627972 2628940 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4, membrane subunit 2627972..2628940 Escherichia coli IAI1 7126018 YP_002387923.1 CDS hyfD NC_011741.1 2629043 2630395 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4 subunit D 2629043..2630395 Escherichia coli IAI1 7126019 YP_002387924.1 CDS hyfE NC_011741.1 2630407 2631057 D interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 2630407..2631057 Escherichia coli IAI1 7126020 YP_002387925.1 CDS hyfF NC_011741.1 2631062 2632642 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4 subunit F 2631062..2632642 Escherichia coli IAI1 7126021 YP_002387926.1 CDS hyfG NC_011741.1 2632680 2634347 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type c : carrier; hydrogenase 4 subunit 2632680..2634347 Escherichia coli IAI1 7126022 YP_002387927.1 CDS hyfH NC_011741.1 2634357 2634896 D probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far; hydrogenase 4 subunit H 2634357..2634896 Escherichia coli IAI1 7126023 YP_002387928.1 CDS hyfI NC_011741.1 2634893 2635651 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type c : carrier; hydrogenase 4, Fe-S subunit 2634893..2635651 Escherichia coli IAI1 7126024 YP_002387929.1 CDS hyfJ NC_011741.1 2635644 2636057 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9387241; Product type pf : putative factor; putative processing element hydrogenase 4 2635644..2636057 Escherichia coli IAI1 7126025 YP_002387930.1 CDS hyfR NC_011741.1 2636087 2638099 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type r : regulator; DNA-binding transcriptional activator, formate sensing 2636087..2638099 Escherichia coli IAI1 7126026 YP_002387931.1 CDS perM NC_011741.1 2639006 2640067 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease complement(2639006..2640067) Escherichia coli IAI1 7127258 YP_002387932.1 CDS yfgC NC_011741.1 2640280 2641743 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 2640280..2641743 Escherichia coli IAI1 7124177 YP_002387933.1 CDS yfgD NC_011741.1 2641764 2642123 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 2641764..2642123 Escherichia coli IAI1 7125860 YP_002387934.1 CDS hda NC_011741.1 2642261 2643007 R controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor complement(2642261..2643007) Escherichia coli IAI1 7125861 YP_002387935.1 CDS uraA NC_011741.1 2643057 2644346 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8332529, 7721693; Product type t : transporter; uracil transporter complement(2643057..2644346) Escherichia coli IAI1 7128498 YP_002387936.1 CDS upp NC_011741.1 2644432 2645058 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(2644432..2645058) Escherichia coli IAI1 7125547 YP_002387937.1 CDS purM NC_011741.1 2645383 2646420 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2645383..2646420 Escherichia coli IAI1 7125546 YP_002387938.1 CDS purN NC_011741.1 2646420 2647058 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 2646420..2647058 Escherichia coli IAI1 7126553 YP_002387939.1 CDS ppk NC_011741.1 2647229 2649295 D catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2647229..2649295 Escherichia coli IAI1 7126554 YP_002387940.1 CDS ppx NC_011741.1 2649300 2650841 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93107072, 94025037, 94165003, 8212131, 8380170; Product type e : enzyme; exopolyphosphatase 2649300..2650841 Escherichia coli IAI1 7126136 YP_002387941.1 CDS yfgF NC_011741.1 2650880 2653123 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2650880..2653123) Escherichia coli IAI1 7126139 YP_002387942.1 CDS ECIAI1_2556 NC_011741.1 2653340 2653630 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2653340..2653630) Escherichia coli IAI1 7125862 YP_002387943.1 CDS yfgH NC_011741.1 2653977 2654495 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein 2653977..2654495 Escherichia coli IAI1 7127724 YP_002387944.1 CDS yfgI NC_011741.1 2654511 2655050 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2654511..2655050 Escherichia coli IAI1 7125863 YP_002387945.1 CDS guaA NC_011741.1 2655145 2656722 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(2655145..2656722) Escherichia coli IAI1 7125864 YP_002387946.1 CDS guaB NC_011741.1 2656791 2658257 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(2656791..2658257) Escherichia coli IAI1 7128476 YP_002387947.1 CDS xseA NC_011741.1 2658419 2659789 D bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2658419..2659789 Escherichia coli IAI1 7128477 YP_002387948.1 CDS yfgJ NC_011741.1 2659786 2660001 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2659786..2660001) Escherichia coli IAI1 7126474 YP_002387949.1 CDS engA NC_011741.1 2660070 2661542 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(2660070..2661542) Escherichia coli IAI1 7125865 YP_002387950.1 CDS yfgL NC_011741.1 2661660 2662838 R with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL complement(2661660..2662838) Escherichia coli IAI1 7124569 YP_002387951.1 CDS yfgM NC_011741.1 2662849 2663469 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2662849..2663469) Escherichia coli IAI1 7125866 YP_002387952.1 CDS hisS NC_011741.1 2663487 2664761 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(2663487..2664761) Escherichia coli IAI1 7125867 YP_002387953.1 CDS ispG NC_011741.1 2664872 2665990 R catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase complement(2664872..2665990) Escherichia coli IAI1 7125496 YP_002387954.1 CDS yfgA NC_011741.1 2666017 2667030 R Evidence 4 : Homologs of previously reported genes of unknown function; cytoskeletal protein RodZ complement(2666017..2667030) Escherichia coli IAI1 7126084 YP_002387955.1 CDS yfgB NC_011741.1 2667315 2668469 R 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N complement(2667315..2668469) Escherichia coli IAI1 7125858 YP_002387956.1 CDS ndk NC_011741.1 2668619 2669050 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(2668619..2669050) Escherichia coli IAI1 7125859 YP_002387957.1 CDS pbpC NC_011741.1 2669199 2671511 R penicillin-insensitive transglycosylase/transpeptidase; penicillin-binding protein 1C complement(2669199..2671511) Escherichia coli IAI1 7127864 YP_002387958.1 CDS yfhM NC_011741.1 2671512 2676473 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2671512..2676473) Escherichia coli IAI1 7124157 YP_002387959.1 CDS sseA NC_011741.1 2676680 2677525 D catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 2676680..2677525 Escherichia coli IAI1 7125876 YP_002387960.1 CDS sseB NC_011741.1 2678018 2678794 R enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB complement(2678018..2678794) Escherichia coli IAI1 7124657 YP_002387961.1 CDS pepB NC_011741.1 2678936 2680219 R catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase B complement(2678936..2680219) Escherichia coli IAI1 7127981 YP_002387962.1 CDS yfhJ NC_011741.1 2680397 2680597 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10393315; Product type pf : putative factor; hypothetical protein complement(2680397..2680597) Escherichia coli IAI1 7124170 YP_002387963.1 CDS fdx NC_011741.1 2680609 2680944 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10393315, 20013001, 92283811, 94181532, 11551196, 1317854, 4375562, 8300516; Product type c : carrier; [2Fe-2S] ferredoxin complement(2680609..2680944) Escherichia coli IAI1 7125873 YP_002387964.1 CDS hscA NC_011741.1 2680946 2682796 R involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA complement(2680946..2682796) Escherichia coli IAI1 7127082 YP_002387965.1 CDS hscB NC_011741.1 2682813 2683328 R J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB complement(2682813..2683328) Escherichia coli IAI1 7125309 YP_002387966.1 CDS iscA NC_011741.1 2683424 2683747 R forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein complement(2683424..2683747) Escherichia coli IAI1 7125310 YP_002387967.1 CDS iscU NC_011741.1 2683764 2684150 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10393315, 11994302, 15153099; Product type f : factor; scaffold protein complement(2683764..2684150) Escherichia coli IAI1 7126074 YP_002387968.1 CDS iscS NC_011741.1 2684178 2685392 R catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase complement(2684178..2685392) Escherichia coli IAI1 7126077 YP_002387969.1 CDS iscR NC_011741.1 2685504 2685992 R regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR complement(2685504..2685992) Escherichia coli IAI1 7126076 YP_002387970.1 CDS yfhQ NC_011741.1 2686293 2687030 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10393315; Product type pe : putative enzyme; putative methyltransferase complement(2686293..2687030) Escherichia coli IAI1 7126075 YP_002387971.1 CDS suhB NC_011741.1 2687149 2687952 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6389495, 90202735, 95095968, 10747806, 2138605, 8002619; Product type e : enzyme; inositol monophosphatase 2687149..2687952 Escherichia coli IAI1 7125877 YP_002387972.1 CDS yfhR NC_011741.1 2688070 2688951 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 2688070..2688951 Escherichia coli IAI1 7126200 YP_002387973.1 CDS csiE NC_011741.1 2689142 2690422 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95020540, 96154950; Product type cp : cell process; stationary phase inducible protein CsiE 2689142..2690422 Escherichia coli IAI1 7125878 YP_002387974.1 CDS hcaT NC_011741.1 2690414 2691553 R putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; putative 3-phenylpropionic acid transporter complement(2690414..2691553) Escherichia coli IAI1 7125929 YP_002387975.1 CDS hcaR NC_011741.1 2691713 2692603 R activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional regulator HcaR complement(2691713..2692603) Escherichia coli IAI1 7128494 YP_002387976.1 CDS hcaE NC_011741.1 2692739 2694100 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83238171, 87008429, 98269008; Product type e : enzyme; 3-phenylpropionate dioxygenase, large alpha subunit 2692739..2694100 Escherichia coli IAI1 7128493 YP_002387977.1 CDS hcaF NC_011741.1 2694097 2694615 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83238171, 87008429, 98269008, 9603882; Product type e : enzyme; 3-phenylpropionate dioxygenase subunit beta 2694097..2694615 Escherichia coli IAI1 7128491 YP_002387978.1 CDS hcaC NC_011741.1 2694615 2694935 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98269008, 9603882; Product type pc : putative carrier; 3-phenylpropionate dioxygenase ferredoxin subunit 2694615..2694935 Escherichia coli IAI1 7128492 YP_002387979.1 CDS hcaB NC_011741.1 2694932 2695744 D Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 2694932..2695744 Escherichia coli IAI1 7128488 YP_002387980.1 CDS yphA NC_011741.1 2696980 2697474 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2696980..2697474 Escherichia coli IAI1 7128490 YP_002387981.1 CDS yphB NC_011741.1 2697522 2698394 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2697522..2698394) Escherichia coli IAI1 7124326 YP_002387982.1 CDS yphC NC_011741.1 2698406 2699467 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(2698406..2699467) Escherichia coli IAI1 7124327 YP_002387983.1 CDS yphD NC_011741.1 2699533 2700531 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter membrane protein complement(2699533..2700531) Escherichia coli IAI1 7124328 YP_002387984.1 CDS yphE NC_011741.1 2700556 2702067 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter ATP-binding protein complement(2700556..2702067) Escherichia coli IAI1 7124329 YP_002387985.1 CDS yphF NC_011741.1 2702090 2703073 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pt : putative transporter; putative sugar ABC transporter periplasmic-binding protein complement(2702090..2703073) Escherichia coli IAI1 7124330 YP_002387986.1 CDS yphG NC_011741.1 2703170 2706451 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2703170..2706451) Escherichia coli IAI1 7124331 YP_002387987.1 CDS yphH NC_011741.1 2706569 2707762 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2706569..2707762 Escherichia coli IAI1 7124332 YP_002387988.1 CDS glyA NC_011741.1 2707826 2709079 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(2707826..2709079) Escherichia coli IAI1 7124333 YP_002387989.1 CDS hmp NC_011741.1 2709408 2710598 D flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 2709408..2710598 Escherichia coli IAI1 7128358 YP_002387990.1 CDS glnB NC_011741.1 2710643 2710981 R indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 complement(2710643..2710981) Escherichia coli IAI1 7125285 YP_002387991.1 CDS yfhA NC_011741.1 2711042 2712376 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8226691, 8412694; Product type pr : putative regulator; putative DNA-binding response regulator in two-component system complement(2711042..2712376) Escherichia coli IAI1 7128322 YP_002387992.1 CDS yfhG NC_011741.1 2712366 2713079 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2712366..2713079) Escherichia coli IAI1 7125868 YP_002387993.1 CDS ECIAI1_2609 NC_011741.1 2713013 2713177 D hypothetical protein 2713013..2713177 Escherichia coli IAI1 7125871 YP_002387994.1 CDS yfhK NC_011741.1 2713243 2714670 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative sensory kinase in two-component system complement(2713243..2714670) Escherichia coli IAI1 7127725 YP_002387995.1 CDS purL NC_011741.1 2715246 2719133 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase complement(2715246..2719133) Escherichia coli IAI1 7127450 YP_002387996.1 CDS yfhD NC_011741.1 2719529 2720947 D YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; putative transglycosylase 2719529..2720947 Escherichia coli IAI1 7126552 YP_002387997.1 CDS tadA NC_011741.1 2720944 2721480 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12110595; Product type e : enzyme; tRNA-specific adenosine deaminase complement(2720944..2721480) Escherichia coli IAI1 7125870 YP_002387998.1 CDS yfhB NC_011741.1 2721505 2722140 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2721505..2722140) Escherichia coli IAI1 7126206 YP_002387999.1 CDS yfhH NC_011741.1 2722349 2723197 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2722349..2723197 Escherichia coli IAI1 7125869 YP_002388000.1 CDS ECIAI1_2617 NC_011741.1 2723342 2723773 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2723342..2723773 Escherichia coli IAI1 7125872 YP_002388001.1 CDS ECIAI1_2618 NC_011741.1 2723832 2724479 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2723832..2724479 Escherichia coli IAI1 7127726 YP_002388002.1 CDS ECIAI1_2619 NC_011741.1 2724712 2724858 D Evidence 6 : Doubtful CDS; hypothetical protein 2724712..2724858 Escherichia coli IAI1 7127727 YP_002388003.1 CDS ECIAI1_2620 NC_011741.1 2725054 2726121 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative O-acyltransferase, transmembrane 2725054..2726121 Escherichia coli IAI1 7127728 YP_002388004.1 CDS ECIAI1_2621 NC_011741.1 2726377 2726817 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail fiber assembly protein complement(2726377..2726817) Escherichia coli IAI1 7127729 YP_002388005.1 CDS ECIAI1_2622 NC_011741.1 2726793 2727878 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative bacteriophage protein complement(2726793..2727878) Escherichia coli IAI1 7127730 YP_002388006.1 CDS ECIAI1_2623 NC_011741.1 2726843 2727016 R hypothetical protein complement(2726843..2727016) Escherichia coli IAI1 7127731 YP_002388007.1 CDS ECIAI1_2624 NC_011741.1 2727860 2728540 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2727860..2728540) Escherichia coli IAI1 7127732 YP_002388008.1 CDS ECIAI1_2625 NC_011741.1 2728537 2729736 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2728537..2729736) Escherichia coli IAI1 7127733 YP_002388009.1 CDS ECIAI1_2626 NC_011741.1 2729736 2730089 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2729736..2730089) Escherichia coli IAI1 7127734 YP_002388010.1 CDS ECIAI1_2627 NC_011741.1 2730089 2730841 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2730089..2730841) Escherichia coli IAI1 7127735 YP_002388011.1 CDS ECIAI1_2628 NC_011741.1 2730903 2731082 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(2730903..2731082) Escherichia coli IAI1 7127736 YP_002388012.1 CDS ECIAI1_2629 NC_011741.1 2731616 2731969 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; hypothetical protein complement(2731616..2731969) Escherichia coli IAI1 7127737 YP_002388013.1 CDS ECIAI1_2630 NC_011741.1 2731969 2733036 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2731969..2733036) Escherichia coli IAI1 7127738 YP_002388014.1 CDS ECIAI1_2631 NC_011741.1 2733039 2733341 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2733039..2733341) Escherichia coli IAI1 7127739 YP_002388015.1 CDS ECIAI1_2632 NC_011741.1 2733341 2733928 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2733341..2733928) Escherichia coli IAI1 7127740 YP_002388016.1 CDS ECIAI1_2633 NC_011741.1 2733928 2735934 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2733928..2735934) Escherichia coli IAI1 7127741 YP_002388017.1 CDS ECIAI1_2634 NC_011741.1 2736090 2736542 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2736090..2736542) Escherichia coli IAI1 7127742 YP_002388018.1 CDS ECIAI1_2635 NC_011741.1 2736546 2736986 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2736546..2736986) Escherichia coli IAI1 7127743 YP_002388019.1 CDS ECIAI1_2636 NC_011741.1 2736997 2738142 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2736997..2738142) Escherichia coli IAI1 7127744 YP_002388020.1 CDS ECIAI1_2637 NC_011741.1 2738146 2738712 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2738146..2738712) Escherichia coli IAI1 7127745 YP_002388021.1 CDS ECIAI1_2638 NC_011741.1 2738684 2739073 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2738684..2739073) Escherichia coli IAI1 7127746 YP_002388022.1 CDS ECIAI1_2639 NC_011741.1 2739060 2739614 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2739060..2739614) Escherichia coli IAI1 7127747 YP_002388023.1 CDS ECIAI1_2640 NC_011741.1 2739611 2740018 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2739611..2740018) Escherichia coli IAI1 7127748 YP_002388024.1 CDS ECIAI1_2641 NC_011741.1 2739984 2740205 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2739984..2740205) Escherichia coli IAI1 7127749 YP_002388025.1 CDS ECIAI1_2642 NC_011741.1 2740247 2741188 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2740247..2741188) Escherichia coli IAI1 7127750 YP_002388026.1 CDS ECIAI1_2643 NC_011741.1 2741200 2741706 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2741200..2741706) Escherichia coli IAI1 7127751 YP_002388027.1 CDS ECIAI1_2644 NC_011741.1 2741710 2742930 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2741710..2742930) Escherichia coli IAI1 7127752 YP_002388028.1 CDS ECIAI1_2645 NC_011741.1 2742945 2743718 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2742945..2743718) Escherichia coli IAI1 7127753 YP_002388029.1 CDS ECIAI1_2646 NC_011741.1 2743567 2745036 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2743567..2745036) Escherichia coli IAI1 7127754 YP_002388030.1 CDS ECIAI1_2647 NC_011741.1 2745036 2746658 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2745036..2746658) Escherichia coli IAI1 7127755 YP_002388031.1 CDS ECIAI1_2648 NC_011741.1 2746661 2747233 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Terminase small subunit complement(2746661..2747233) Escherichia coli IAI1 7127756 YP_002388032.1 CDS ECIAI1_2649 NC_011741.1 2747295 2747819 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative exported protein from phage origin complement(2747295..2747819) Escherichia coli IAI1 7127757 YP_002388033.1 CDS r NC_011741.1 2747803 2748279 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Lysozyme complement(2747803..2748279) Escherichia coli IAI1 7127758 YP_002388034.1 CDS S NC_011741.1 2748283 2748642 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2998005; Product type h : extrachromosomal origin; Holin complement(2748283..2748642) Escherichia coli IAI1 7126585 YP_002388035.1 CDS Q NC_011741.1 2749028 2749462 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; antitermination protein Q (P5) complement(2749028..2749462) Escherichia coli IAI1 7124668 YP_002388036.1 CDS ECIAI1_2653 NC_011741.1 2749649 2749846 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(2749649..2749846) Escherichia coli IAI1 7126578 YP_002388037.1 CDS ECIAI1_2654 NC_011741.1 2749749 2751935 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2749749..2751935) Escherichia coli IAI1 7127759 YP_002388038.1 CDS ECIAI1_2655 NC_011741.1 2751939 2752139 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative protein P2 from bacteriophage origin (fragment) complement(2751939..2752139) Escherichia coli IAI1 7127760 YP_002388039.1 CDS ECIAI1_2656 NC_011741.1 2752281 2752955 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10489345; Product type f : factor; putative repressor CI from bacteriophage origin 2752281..2752955 Escherichia coli IAI1 7127761 YP_002388040.1 CDS ECIAI1_2657 NC_011741.1 2753013 2753237 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2753013..2753237) Escherichia coli IAI1 7127762 YP_002388041.1 CDS ECIAI1_2658 NC_011741.1 2753374 2753898 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative coiled-coil protein from phage origin complement(2753374..2753898) Escherichia coli IAI1 7127763 YP_002388042.1 CDS ECIAI1_2659 NC_011741.1 2754091 2754261 D Evidence 6 : Doubtful CDS; Product type h : extrachromosomal origin; hypothetical protein 2754091..2754261 Escherichia coli IAI1 7125497 YP_002388043.1 CDS ECIAI1_2660 NC_011741.1 2754258 2755160 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2754258..2755160 Escherichia coli IAI1 7127765 YP_002388044.1 CDS ECIAI1_2661 NC_011741.1 2755163 2756464 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10489345; hypothetical protein 2755163..2756464 Escherichia coli IAI1 7127766 YP_002388045.1 CDS ECIAI1_2662 NC_011741.1 2756480 2757028 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2756480..2757028 Escherichia coli IAI1 7127767 YP_002388046.1 CDS ECIAI1_2663 NC_011741.1 2757081 2757710 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein complement(2757081..2757710) Escherichia coli IAI1 7127768 YP_002388047.1 CDS ECIAI1_2664 NC_011741.1 2757757 2759820 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10489345; Product type pe : putative enzyme; putative DNA polymerase from bacteriophage origin 2757757..2759820 Escherichia coli IAI1 7127769 YP_002388048.1 CDS ECIAI1_2665 NC_011741.1 2759885 2760646 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2759885..2760646 Escherichia coli IAI1 7127770 YP_002388049.1 CDS ECIAI1_2666 NC_011741.1 2760881 2761075 D hypothetical protein 2760881..2761075 Escherichia coli IAI1 7127771 YP_002388050.1 CDS ECIAI1_2667 NC_011741.1 2761075 2761362 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10489345; Product type h : extrachromosomal origin; hypothetical protein 2761075..2761362 Escherichia coli IAI1 7127772 YP_002388051.1 CDS ECIAI1_2668 NC_011741.1 2761375 2762172 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein complement(2761375..2762172) Escherichia coli IAI1 7127773 YP_002388052.1 CDS ECIAI1_2669 NC_011741.1 2762240 2763634 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10489345; Product type h : extrachromosomal origin; hypothetical protein 2762240..2763634 Escherichia coli IAI1 7127774 YP_002388053.1 CDS ECIAI1_2670 NC_011741.1 2763631 2763831 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2763631..2763831 Escherichia coli IAI1 7127775 YP_002388054.1 CDS ECIAI1_2671 NC_011741.1 2763828 2765231 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; hypothetical protein complement(2763828..2765231) Escherichia coli IAI1 7128527 YP_002388055.1 CDS yfhL NC_011741.1 2765440 2765700 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8765743, 8880900; Product type c : carrier; ferredoxin 2765440..2765700 Escherichia coli IAI1 7128528 YP_002388056.1 CDS ECIAI1_2673 NC_011741.1 2765971 2766135 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2765971..2766135) Escherichia coli IAI1 7124658 YP_002388057.1 CDS acpS NC_011741.1 2766395 2766775 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(2766395..2766775) Escherichia coli IAI1 7124659 YP_002388058.1 CDS pdxJ NC_011741.1 2766775 2767506 R involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase complement(2766775..2767506) Escherichia coli IAI1 7125704 YP_002388059.1 CDS recO NC_011741.1 2767518 2768246 R involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO complement(2767518..2768246) Escherichia coli IAI1 7124166 YP_002388060.1 CDS era NC_011741.1 2768258 2769163 R Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era complement(2768258..2769163) Escherichia coli IAI1 7124953 YP_002388061.1 CDS rnc NC_011741.1 2769160 2769840 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(2769160..2769840) Escherichia coli IAI1 7125088 YP_002388062.1 CDS lepB NC_011741.1 2770113 2771087 R catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I complement(2770113..2771087) Escherichia coli IAI1 7125498 YP_002388063.1 CDS lepA NC_011741.1 2771103 2772902 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(2771103..2772902) Escherichia coli IAI1 7126406 YP_002388064.1 CDS ECIAI1_2682 NC_011741.1 2773036 2773170 D hypothetical protein 2773036..2773170 Escherichia coli IAI1 7126405 YP_002388065.1 CDS rseC NC_011741.1 2773100 2773579 R involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC complement(2773100..2773579) Escherichia coli IAI1 7128530 YP_002388066.1 CDS rseB NC_011741.1 2773576 2774532 R periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE complement(2773576..2774532) Escherichia coli IAI1 7128434 YP_002388067.1 CDS rseA NC_011741.1 2774532 2775182 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9159522, 97303092, 99431977, 7768826; Product type f : factor; anti-RNA polymerase sigma factor SigE complement(2774532..2775182) Escherichia coli IAI1 7128433 YP_002388068.1 CDS rpoE NC_011741.1 2775215 2775790 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE complement(2775215..2775790) Escherichia coli IAI1 7128432 YP_002388069.1 CDS nadB NC_011741.1 2776198 2777820 D catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 2776198..2777820 Escherichia coli IAI1 7128400 YP_002388070.1 CDS yfiC NC_011741.1 2777805 2778542 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase complement(2777805..2778542) Escherichia coli IAI1 7124512 YP_002388071.1 CDS srmB NC_011741.1 2778674 2780008 D facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2778674..2780008 Escherichia coli IAI1 7125881 YP_002388072.1 CDS ECIAI1_2692 NC_011741.1 2780279 2781259 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 2780279..2781259 Escherichia coli IAI1 7127976 YP_002388073.1 CDS yfiE NC_011741.1 2781496 2782377 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(2781496..2782377) Escherichia coli IAI1 7128531 YP_002388074.1 CDS yfiK NC_011741.1 2782480 2783067 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12562784; Product type t : transporter; neutral amino-acid efflux protein 2782480..2783067 Escherichia coli IAI1 7125883 YP_002388075.1 CDS yfiD NC_011741.1 2783123 2783506 R stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA complement(2783123..2783506) Escherichia coli IAI1 7125886 YP_002388076.1 CDS ung NC_011741.1 2783811 2784500 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2783811..2784500 Escherichia coli IAI1 7125882 YP_002388077.1 CDS yfiF NC_011741.1 2784548 2785585 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase complement(2784548..2785585) Escherichia coli IAI1 7125545 YP_002388078.1 CDS ECIAI1_2699 NC_011741.1 2785575 2785778 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2785575..2785778) Escherichia coli IAI1 7125884 YP_002388079.1 CDS trxC NC_011741.1 2785792 2786211 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12952960, 9388228, 99175138, 10644706; Product type c : carrier; thioredoxin 2 2785792..2786211 Escherichia coli IAI1 7128532 YP_002388080.1 CDS yfiP NC_011741.1 2786280 2786978 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2786280..2786978 Escherichia coli IAI1 7127508 YP_002388081.1 CDS yfiQ NC_011741.1 2787010 2789670 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; acyl-CoA synthetase NAD(P)-binding/ATP-binding subunit 2787010..2789670 Escherichia coli IAI1 7125891 YP_002388082.1 CDS pssA NC_011741.1 2789784 2791139 D catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 2789784..2791139 Escherichia coli IAI1 7125892 YP_002388083.1 CDS yfiM NC_011741.1 2791236 2791508 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2791236..2791508 Escherichia coli IAI1 7126529 YP_002388084.1 CDS kgtP NC_011741.1 2791505 2792803 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91219460, 1709493, 2053984, 2118499, 2190187, 8419306; Product type t : transporter; alpha-ketoglutarate transporter complement(2791505..2792803) Escherichia coli IAI1 7125888 YP_002388085.1 CDS clpB NC_011741.1 2798666 2801239 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14550559, 14640692, 91294166, 93015925, 93388583, 99428468; Product type f : factor; protein disaggregation chaperone complement(2798666..2801239) Escherichia coli IAI1 7126787 YP_002388086.1 CDS yfiH NC_011741.1 2801369 2802100 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1906060, 2066329; hypothetical protein complement(2801369..2802100) Escherichia coli IAI1 7124660 YP_002388087.1 CDS rluD NC_011741.1 2802097 2803077 R responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D complement(2802097..2803077) Escherichia coli IAI1 7125885 YP_002388088.1 CDS yfiO NC_011741.1 2803212 2803949 D with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 2803212..2803949 Escherichia coli IAI1 7125012 YP_002388089.1 CDS yfiA NC_011741.1 2804220 2804561 D associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 2804220..2804561 Escherichia coli IAI1 7125890 YP_002388091.1 CDS pheA NC_011741.1 2804811 2805971 D catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 2804811..2805971 Escherichia coli IAI1 7124193 YP_002388092.1 CDS tyrA NC_011741.1 2806014 2807135 R catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase complement(2806014..2807135) Escherichia coli IAI1 7124192 YP_002388093.1 CDS aroF NC_011741.1 2807146 2808216 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(2807146..2808216) Escherichia coli IAI1 7127525 YP_002388094.1 CDS yfiL NC_011741.1 2808426 2808791 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6396419; hypothetical protein 2808426..2808791 Escherichia coli IAI1 7125807 YP_002388095.1 CDS yfiR NC_011741.1 2808941 2809459 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2808941..2809459 Escherichia coli IAI1 7125887 YP_002388096.1 CDS yfiN NC_011741.1 2809449 2810675 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; hypothetical protein 2809449..2810675 Escherichia coli IAI1 7125893 YP_002388097.1 CDS yfiB NC_011741.1 2810691 2811173 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96032391; Product type pm : putative membrane component; putative outer membrane lipoprotein 2810691..2811173 Escherichia coli IAI1 7125889 YP_002388098.1 CDS rplS NC_011741.1 2811250 2811597 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(2811250..2811597) Escherichia coli IAI1 7125880 YP_002388099.1 CDS trmD NC_011741.1 2811639 2812406 R methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase complement(2811639..2812406) Escherichia coli IAI1 7128380 YP_002388100.1 CDS rimM NC_011741.1 2812437 2812985 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(2812437..2812985) Escherichia coli IAI1 7127490 YP_002388101.1 CDS rpsP NC_011741.1 2813004 2813252 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(2813004..2813252) Escherichia coli IAI1 7125005 YP_002388102.1 CDS ECIAI1_2731 NC_011741.1 2813363 2813536 R hypothetical protein complement(2813363..2813536) Escherichia coli IAI1 7128422 YP_002388103.1 CDS ffh NC_011741.1 2813389 2814750 R with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein complement(2813389..2814750) Escherichia coli IAI1 7128533 YP_002388104.1 CDS ypjD NC_011741.1 2814842 2815708 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2814842..2815708 Escherichia coli IAI1 7127094 YP_002388105.1 CDS yfjD NC_011741.1 2815819 2817015 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2815819..2817015 Escherichia coli IAI1 7124337 YP_002388106.1 CDS grpE NC_011741.1 2817070 2817663 R with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(2817070..2817663) Escherichia coli IAI1 7125895 YP_002388107.1 CDS ppnK NC_011741.1 2817786 2818664 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 2817786..2818664 Escherichia coli IAI1 7128467 YP_002388108.1 CDS recN NC_011741.1 2818750 2820411 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87259985, 91355307, 95058623, 3037486; Product type cp : cell process; recombination and repair protein 2818750..2820411 Escherichia coli IAI1 7125894 YP_002388109.1 CDS smpA NC_011741.1 2820560 2820901 D Evidence 2b : Function of strongly homologous gene; PubMedId : 2045357; Product type lp : lipoprotein; hypothetical protein 2820560..2820901 Escherichia coli IAI1 7124952 YP_002388110.1 CDS yfjF NC_011741.1 2820963 2821253 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2820963..2821253) Escherichia coli IAI1 7127938 YP_002388111.1 CDS yfjG NC_011741.1 2821243 2821719 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2821243..2821719) Escherichia coli IAI1 7125896 YP_002388112.1 CDS smpB NC_011741.1 2821851 2822333 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 2821851..2822333 Escherichia coli IAI1 7125897 YP_002388113.1 CDS ECIAI1_2745 NC_011741.1 2825329 2825592 D Evidence 2b : Function of strongly homologous gene; PubMedId : 15126494, 7737514; Product type pe : putative enzyme; transposase, ORF A, IS3 family, IS407 group 2825329..2825592 Escherichia coli IAI1 7124335 YP_002388114.1 CDS ECIAI1_2746 NC_011741.1 2825616 2826449 D Evidence 2b : Function of strongly homologous gene; PubMedId : 1718819, 7737514; Product type pe : putative enzyme; transposase, ORF B, IS3 family, IS407 group 2825616..2826449 Escherichia coli IAI1 7128534 YP_002388115.1 CDS ECIAI1_2748 NC_011741.1 2827827 2828084 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative DNA invertase fragment pinH complement(2827827..2828084) Escherichia coli IAI1 7124336 YP_002388116.1 CDS ECIAI1_2749 NC_011741.1 2827870 2828343 D Evidence 6 : Doubtful CDS; hypothetical protein 2827870..2828343 Escherichia coli IAI1 7128536 YP_002388117.1 CDS ECIAI1_2752 NC_011741.1 2830362 2830691 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2830362..2830691) Escherichia coli IAI1 7128539 YP_002388118.1 CDS ECIAI1_2753 NC_011741.1 2831233 2833074 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative alpha-amylase 2831233..2833074 Escherichia coli IAI1 7128045 YP_002388119.1 CDS yqaD NC_011741.1 2833213 2833485 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2833213..2833485 Escherichia coli IAI1 7128541 YP_002388120.1 CDS ygaT NC_011741.1 2833821 2834798 D in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 2833821..2834798 Escherichia coli IAI1 7124340 YP_002388121.1 CDS ygaF NC_011741.1 2834818 2836086 D catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 2834818..2836086 Escherichia coli IAI1 7125904 YP_002388122.1 CDS gabD NC_011741.1 2836109 2837557 D catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; succinate-semialdehyde dehydrogenase I 2836109..2837557 Escherichia coli IAI1 7125900 YP_002388123.1 CDS gabT NC_011741.1 2837571 2838851 D catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 2837571..2838851 Escherichia coli IAI1 7128258 YP_002388124.1 CDS gabP NC_011741.1 2839162 2840562 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94127927, 9685361, 8297211; Product type t : transporter; gamma-aminobutyrate transporter 2839162..2840562 Escherichia coli IAI1 7128260 YP_002388125.1 CDS csiR NC_011741.1 2840583 2841245 D regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 2840583..2841245 Escherichia coli IAI1 7128259 YP_002388126.1 CDS ygaU NC_011741.1 2841246 2841695 R Evidence 4 : Homologs of previously reported genes of unknown function; LysM domain/BON superfamily protein complement(2841246..2841695) Escherichia coli IAI1 7125930 YP_002388127.1 CDS yqaE NC_011741.1 2841779 2841937 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2841779..2841937) Escherichia coli IAI1 7125905 YP_002388128.1 CDS ygaV NC_011741.1 2842120 2842419 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2842120..2842419 Escherichia coli IAI1 7124341 YP_002388129.1 CDS ygaP NC_011741.1 2842429 2842953 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : putative enzyme; hypothetical protein 2842429..2842953 Escherichia coli IAI1 7125906 YP_002388130.1 CDS stpA NC_011741.1 2843000 2843404 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20485613, 93126121, 9643551, 98132400, 99415935, 1480493, 7961433; Product type r : regulator; DNA binding protein, nucleoid-associated complement(2843000..2843404) Escherichia coli IAI1 7125903 YP_002388131.1 CDS ygaW NC_011741.1 2844072 2844521 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2844072..2844521 Escherichia coli IAI1 7126187 YP_002388132.1 CDS ygaC NC_011741.1 2844558 2844902 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7961433; hypothetical protein complement(2844558..2844902) Escherichia coli IAI1 7125907 YP_002388133.1 CDS ygaM NC_011741.1 2845042 2845383 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2845042..2845383 Escherichia coli IAI1 7125898 YP_002388134.1 CDS nrdH NC_011741.1 2845631 2845876 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9218434, 11441020, 8820648; Product type pc : putative carrier; glutaredoxin-like protein 2845631..2845876 Escherichia coli IAI1 7125902 YP_002388135.1 CDS nrdI NC_011741.1 2845873 2846283 D in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 2845873..2846283 Escherichia coli IAI1 7125939 YP_002388136.1 CDS nrdE NC_011741.1 2846256 2848400 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2846256..2848400 Escherichia coli IAI1 7125940 YP_002388137.1 CDS nrdF NC_011741.1 2848410 2849369 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 2848410..2849369 Escherichia coli IAI1 7127903 YP_002388138.1 CDS proV NC_011741.1 2849724 2850926 D with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding subunit 2849724..2850926 Escherichia coli IAI1 7127856 YP_002388139.1 CDS proW NC_011741.1 2850919 2851983 D with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 2850919..2851983 Escherichia coli IAI1 7126162 YP_002388140.1 CDS proX NC_011741.1 2852040 2853032 D with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 2852040..2853032 Escherichia coli IAI1 7126163 YP_002388141.1 CDS ECIAI1_2776 NC_011741.1 2853324 2854508 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16000740; Product type pt : putative transporter; putative transport protein 2853324..2854508 Escherichia coli IAI1 7126164 YP_002388142.1 CDS ygaZ NC_011741.1 2854632 2855369 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 2854632..2855369 Escherichia coli IAI1 7128542 YP_002388143.1 CDS ygaH NC_011741.1 2855359 2855694 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2855359..2855694 Escherichia coli IAI1 7125908 YP_002388144.1 CDS mprA NC_011741.1 2855785 2856315 D DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 2855785..2856315 Escherichia coli IAI1 7125901 YP_002388145.1 CDS emrA NC_011741.1 2856442 2857614 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 93285984, 94262163, 1409590, 8203018; Product type t : transporter; multidrug efflux system 2856442..2857614 Escherichia coli IAI1 7124465 YP_002388146.1 CDS emrB NC_011741.1 2857631 2859169 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 93285984, 94262163, 1409590; Product type t : transporter; multidrug efflux system protein 2857631..2859169 Escherichia coli IAI1 7125060 YP_002388147.1 CDS luxS NC_011741.1 2859233 2859748 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(2859233..2859748) Escherichia coli IAI1 7125061 YP_002388148.1 CDS gshA NC_011741.1 2859898 2861454 R involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase complement(2859898..2861454) Escherichia coli IAI1 7124272 YP_002388149.1 CDS yqaA NC_011741.1 2861527 2861955 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2861527..2861955) Escherichia coli IAI1 7128471 YP_002388150.1 CDS yqaB NC_011741.1 2861952 2862518 R YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase complement(2861952..2862518) Escherichia coli IAI1 7124338 YP_002388151.1 CDS csrA NC_011741.1 2863569 2863754 R affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator complement(2863569..2863754) Escherichia coli IAI1 7128041 YP_002388152.1 CDS alaS NC_011741.1 2863989 2866619 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(2863989..2866619) Escherichia coli IAI1 7126852 YP_002388153.1 CDS recX NC_011741.1 2866747 2867247 R binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX complement(2866747..2867247) Escherichia coli IAI1 7125740 YP_002388154.1 CDS recA NC_011741.1 2867490 2868551 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(2867490..2868551) Escherichia coli IAI1 7124956 YP_002388155.1 CDS ygaD NC_011741.1 2868631 2869128 R Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A complement(2868631..2869128) Escherichia coli IAI1 7127612 YP_002388156.1 CDS mltB NC_011741.1 2869273 2870358 R membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B complement(2869273..2870358) Escherichia coli IAI1 7125899 YP_002388157.1 CDS srlA NC_011741.1 2870614 2871177 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87194727, 1334233, 3553176; Product type t : transporter; glucitol/sorbitol-specific PTS system transporter subunit IIC 2870614..2871177 Escherichia coli IAI1 7124282 YP_002388158.1 CDS srlE NC_011741.1 2871174 2872133 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1100602, 3553176; Product type t : transporter; glucitol/sorbitol-specific PTS system transporter subunit IIB 2871174..2872133 Escherichia coli IAI1 7127971 YP_002388159.1 CDS srlB NC_011741.1 2872144 2872515 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucitol/sorbitol-specific transporter subunit IIA 2872144..2872515 Escherichia coli IAI1 7127974 YP_002388160.1 CDS srlD NC_011741.1 2872519 2873298 D catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 2872519..2873298 Escherichia coli IAI1 7127972 YP_002388161.1 CDS gutM NC_011741.1 2873403 2873762 D regulator for glucitol utilization; DNA-binding transcriptional activator GutM 2873403..2873762 Escherichia coli IAI1 7127973 YP_002388162.1 CDS srlR NC_011741.1 2873829 2874602 D regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 2873829..2874602 Escherichia coli IAI1 7128483 YP_002388163.1 CDS gutQ NC_011741.1 2874595 2875560 D catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 2874595..2875560 Escherichia coli IAI1 7127975 YP_002388164.1 CDS norR NC_011741.1 2875557 2877071 R Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcription regulator complement(2875557..2877071) Escherichia coli IAI1 7128484 YP_002388165.1 CDS norV NC_011741.1 2877258 2878697 D detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 2877258..2878697 Escherichia coli IAI1 7127896 YP_002388166.1 CDS norW NC_011741.1 2878694 2879827 D catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 2878694..2879827 Escherichia coli IAI1 7127897 YP_002388167.1 CDS hypF NC_011741.1 2880053 2882305 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12377778, 92255260, 8661925; Product type e : enzyme; carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases complement(2880053..2882305) Escherichia coli IAI1 7127898 YP_002388168.1 CDS hydN NC_011741.1 2882458 2882985 R involved in electron transport from formate to hydrogen; electron transport protein HydN complement(2882458..2882985) Escherichia coli IAI1 7126034 YP_002388169.1 CDS ascG NC_011741.1 2883134 2884147 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88297127, 92334140, 1630307; Product type r : regulator; DNA-binding transcriptional repressor complement(2883134..2884147) Escherichia coli IAI1 7125912 YP_002388170.1 CDS ascF NC_011741.1 2884404 2885861 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC 2884404..2885861 Escherichia coli IAI1 7125827 YP_002388171.1 CDS ascB NC_011741.1 2885870 2887294 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88297127, 92334140, 1630307; Product type e : enzyme; cryptic 6-phospho-beta-glucosidase 2885870..2887294 Escherichia coli IAI1 7125826 YP_002388172.1 CDS ECIAI1_2809 NC_011741.1 2887408 2887893 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative HTH-type transcriptional regulator ygjM complement(2887408..2887893) Escherichia coli IAI1 7125825 YP_002388173.1 CDS ECIAI1_2810 NC_011741.1 2887898 2888671 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2887898..2888671) Escherichia coli IAI1 7128543 YP_002388174.1 CDS hycI NC_011741.1 2888696 2889166 R involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease complement(2888696..2889166) Escherichia coli IAI1 7128544 YP_002388175.1 CDS hycH NC_011741.1 2889159 2889569 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 92326636, 1625581, 2187144, 7851435; Product type f : factor; hydrogenase-3 maturation protein complement(2889159..2889569) Escherichia coli IAI1 7127904 YP_002388176.1 CDS hycG NC_011741.1 2889566 2890333 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636, 2187144; Product type e : enzyme; hydrogenase 3 and formate hydrogenase complex, HycG subunit complement(2889566..2890333) Escherichia coli IAI1 7125347 YP_002388177.1 CDS hycF NC_011741.1 2890333 2890875 R electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; formate hydrogenlyase complex iron-sulfur subunit complement(2890333..2890875) Escherichia coli IAI1 7125346 YP_002388178.1 CDS hycE NC_011741.1 2890885 2892594 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 92326636, 94170785, 2187144, 8125094; Product type e : enzyme; hydrogenase 3, large subunit complement(2890885..2892594) Escherichia coli IAI1 7125345 YP_002388179.1 CDS hycD NC_011741.1 2892612 2893535 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636; Product type m : membrane component; hydrogenase 3, membrane subunit complement(2892612..2893535) Escherichia coli IAI1 7125344 YP_002388180.1 CDS hycC NC_011741.1 2893538 2895364 R catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 complement(2893538..2895364) Escherichia coli IAI1 7125343 YP_002388181.1 CDS hycB NC_011741.1 2895361 2895972 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636, 2187144; Product type c : carrier; hydrogenase 3, Fe-S subunit complement(2895361..2895972) Escherichia coli IAI1 7125342 YP_002388182.1 CDS hycA NC_011741.1 2896097 2896558 R regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA complement(2896097..2896558) Escherichia coli IAI1 7125341 YP_002388183.1 CDS hypA NC_011741.1 2896770 2897120 D plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 2896770..2897120 Escherichia coli IAI1 7125340 YP_002388184.1 CDS hypB NC_011741.1 2897124 2897996 D GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 2897124..2897996 Escherichia coli IAI1 7126029 YP_002388185.1 CDS hypC NC_011741.1 2897987 2898259 D HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 2897987..2898259 Escherichia coli IAI1 7126030 YP_002388186.1 CDS hypD NC_011741.1 2898259 2899380 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91194542, 92255260, 1849603; Product type f : factor; hydrogenase maturation protein 2898259..2899380 Escherichia coli IAI1 7126031 YP_002388187.1 CDS hypE NC_011741.1 2899419 2900387 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91194542, 9485446, 1849603; Product type e : enzyme; carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein 2899419..2900387 Escherichia coli IAI1 7126032 YP_002388188.1 CDS fhlA NC_011741.1 2900461 2902539 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20307603, 21557168, 90368529, 92140045, 94018617, 2118503, 2280686; Product type r : regulator; DNA-binding transcriptional activator 2900461..2902539 Escherichia coli IAI1 7126033 YP_002388189.1 CDS ygbA NC_011741.1 2902576 2902929 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2902576..2902929) Escherichia coli IAI1 7127097 YP_002388190.1 CDS mutS NC_011741.1 2903216 2905777 D This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 2903216..2905777 Escherichia coli IAI1 7125909 YP_002388191.1 CDS pphB NC_011741.1 2905883 2906539 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9130712; Product type e : enzyme; serine/threonine-specific protein phosphatase 2 2905883..2906539 Escherichia coli IAI1 7124505 YP_002388192.1 CDS ygbI NC_011741.1 2906590 2907387 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(2906590..2907387) Escherichia coli IAI1 7126131 YP_002388193.1 CDS ygbJ NC_011741.1 2907553 2908461 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dehydrogenase 2907553..2908461 Escherichia coli IAI1 7125937 YP_002388194.1 CDS ygbK NC_011741.1 2908458 2909720 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11520622; hypothetical protein 2908458..2909720 Escherichia coli IAI1 7124866 YP_002388195.1 CDS ygbL NC_011741.1 2909717 2910355 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldolase 2909717..2910355 Escherichia coli IAI1 7124867 YP_002388196.1 CDS ygbM NC_011741.1 2910360 2911136 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2910360..2911136 Escherichia coli IAI1 7124868 YP_002388197.1 CDS ygbN NC_011741.1 2911225 2912589 D member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; inner membrane permease YgbN 2911225..2912589 Escherichia coli IAI1 7124869 YP_002388198.1 CDS ECIAI1_2836 NC_011741.1 2912628 2912864 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme; hypothetical protein complement(2912628..2912864) Escherichia coli IAI1 7124870 YP_002388199.1 CDS ECIAI1_2837 NC_011741.1 2912875 2914302 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme; hypothetical protein complement(2912875..2914302) Escherichia coli IAI1 7128545 YP_002388200.1 CDS ECIAI1_2838 NC_011741.1 2914302 2914895 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme; hypothetical protein complement(2914302..2914895) Escherichia coli IAI1 7128546 YP_002388201.1 CDS ECIAI1_2839 NC_011741.1 2915042 2915449 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15731069; Product type r : regulator; transcriptional regulator hosA 2915042..2915449 Escherichia coli IAI1 7128547 YP_002388202.1 CDS nlpD NC_011741.1 2916625 2917764 R outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD complement(2916625..2917764) Escherichia coli IAI1 7128404 YP_002388203.1 CDS pcm NC_011741.1 2917904 2918530 R catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase complement(2917904..2918530) Escherichia coli IAI1 7127890 YP_002388204.1 CDS surE NC_011741.1 2918524 2919285 R catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE complement(2918524..2919285) Escherichia coli IAI1 7124160 YP_002388205.1 CDS truD NC_011741.1 2919266 2920315 R catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D complement(2919266..2920315) Escherichia coli IAI1 7126203 YP_002388206.1 CDS ispF NC_011741.1 2920312 2920791 R catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase complement(2920312..2920791) Escherichia coli IAI1 7127505 YP_002388207.1 CDS ispD NC_011741.1 2920791 2921501 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(2920791..2921501) Escherichia coli IAI1 7126083 YP_002388208.1 CDS ftsB NC_011741.1 2921520 2921831 R forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB complement(2921520..2921831) Escherichia coli IAI1 7126081 YP_002388209.1 CDS ygbE NC_011741.1 2922025 2922348 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2922025..2922348) Escherichia coli IAI1 7128233 YP_002388210.1 CDS cysC NC_011741.1 2922398 2923003 R converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase complement(2922398..2923003) Escherichia coli IAI1 7125910 YP_002388211.1 CDS cysN NC_011741.1 2923003 2924430 R may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 complement(2923003..2924430) Escherichia coli IAI1 7126889 YP_002388212.1 CDS cysD NC_011741.1 2924432 2925340 R with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 complement(2924432..2925340) Escherichia coli IAI1 7126898 YP_002388213.1 CDS iap NC_011741.1 2925592 2926629 D catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase isozyme conversion aminopeptidase 2925592..2926629 Escherichia coli IAI1 7126890 YP_002388214.1 CDS ygbF NC_011741.1 2927872 2928165 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2927872..2928165) Escherichia coli IAI1 7126038 YP_002388215.1 CDS ygbT NC_011741.1 2928162 2929121 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2928162..2929121) Escherichia coli IAI1 7125911 YP_002388216.1 CDS ECIAI1_2859 NC_011741.1 2929082 2929870 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2929082..2929870) Escherichia coli IAI1 7124871 YP_002388217.1 CDS ECIAI1_2860 NC_011741.1 2929714 2930460 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2929714..2930460) Escherichia coli IAI1 7128549 YP_002388218.1 CDS ECIAI1_2861 NC_011741.1 2930471 2931526 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2930471..2931526) Escherichia coli IAI1 7128550 YP_002388219.1 CDS ECIAI1_2862 NC_011741.1 2931538 2932074 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2931538..2932074) Escherichia coli IAI1 7128551 YP_002388220.1 CDS ECIAI1_2863 NC_011741.1 2932071 2933702 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2932071..2933702) Escherichia coli IAI1 7128552 YP_002388221.1 CDS ECIAI1_2864 NC_011741.1 2933731 2936430 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2933731..2936430) Escherichia coli IAI1 7128553 YP_002388222.1 CDS ECIAI1_2865 NC_011741.1 2936624 2936776 R Evidence 1b : Function experimentally demonstrated in the studied species; Product type pm : putative membrane component; small toxic peptide complement(2936624..2936776) Escherichia coli IAI1 7128554 YP_002388223.1 CDS cysH NC_011741.1 2937041 2937775 R catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase complement(2937041..2937775) Escherichia coli IAI1 7128555 YP_002388224.1 CDS cysI NC_011741.1 2937849 2939561 R hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta complement(2937849..2939561) Escherichia coli IAI1 7126893 YP_002388225.1 CDS cysJ NC_011741.1 2939561 2941360 R catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha complement(2939561..2941360) Escherichia coli IAI1 7126894 YP_002388226.1 CDS ygcM NC_011741.1 2941676 2942041 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123838; Product type e : enzyme; 6-pyruvoyl tetrahydrobiopterin synthase 2941676..2942041 Escherichia coli IAI1 7126895 YP_002388227.1 CDS ygcN NC_011741.1 2942119 2943390 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 2942119..2943390 Escherichia coli IAI1 7124874 YP_002388228.1 CDS ygcO NC_011741.1 2943381 2943641 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S cluster-containing protein 2943381..2943641 Escherichia coli IAI1 7124875 YP_002388229.1 CDS ygcP NC_011741.1 2943658 2944233 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative anti-terminator regulatory protein 2943658..2944233 Escherichia coli IAI1 7124876 YP_002388230.1 CDS ygcQ NC_011741.1 2944381 2945241 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative flavoprotein complement(2944381..2945241) Escherichia coli IAI1 7124877 YP_002388231.1 CDS ygcR NC_011741.1 2945238 2946017 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative flavoprotein complement(2945238..2946017) Escherichia coli IAI1 7124878 YP_002388232.1 CDS ygcS NC_011741.1 2945995 2947332 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(2945995..2947332) Escherichia coli IAI1 7124879 YP_002388233.1 CDS ygcU NC_011741.1 2947426 2948880 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative FAD containing dehydrogenase complement(2947426..2948880) Escherichia coli IAI1 7124880 YP_002388234.1 CDS ygcW NC_011741.1 2948950 2949735 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative deoxygluconate dehydrogenase complement(2948950..2949735) Escherichia coli IAI1 7124881 YP_002388235.1 CDS yqcE NC_011741.1 2950054 2951331 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 2950054..2951331 Escherichia coli IAI1 7124882 YP_002388236.1 CDS ygcE NC_011741.1 2951358 2952836 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative kinase 2951358..2952836 Escherichia coli IAI1 7124344 YP_002388239.1 CDS ygcF NC_011741.1 2955124 2955795 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2955124..2955795) Escherichia coli IAI1 7128557 YP_002388240.1 CDS ECIAI1_2884 NC_011741.1 2955950 2956570 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2955950..2956570 Escherichia coli IAI1 7124873 YP_002388241.1 CDS ECIAI1_2885 NC_011741.1 2956554 2957489 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2956554..2957489 Escherichia coli IAI1 7128558 YP_002388242.1 CDS ECIAI1_2886 NC_011741.1 2957525 2957887 D Evidence 6 : Doubtful CDS; hypothetical protein 2957525..2957887 Escherichia coli IAI1 7128559 YP_002388243.1 CDS eno NC_011741.1 2957943 2959241 R enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase complement(2957943..2959241) Escherichia coli IAI1 7128560 YP_002388244.1 CDS pyrG NC_011741.1 2959329 2960966 R CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase complement(2959329..2960966) Escherichia coli IAI1 7125067 YP_002388245.1 CDS mazG NC_011741.1 2961194 2961985 R functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase complement(2961194..2961985) Escherichia coli IAI1 7126574 YP_002388246.1 CDS chpA NC_011741.1 2962056 2962391 R MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA complement(2962056..2962391) Escherichia coli IAI1 7127677 YP_002388247.1 CDS chpR NC_011741.1 2962391 2962639 R part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE complement(2962391..2962639) Escherichia coli IAI1 7126315 YP_002388248.1 CDS relA NC_011741.1 2962717 2964951 R (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase complement(2962717..2964951) Escherichia coli IAI1 7126317 YP_002388249.1 CDS rumA NC_011741.1 2964999 2966300 R in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase complement(2964999..2966300) Escherichia coli IAI1 7124957 YP_002388250.1 CDS barA NC_011741.1 2966357 2969113 D part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; hybrid sensory histidine kinase BarA 2966357..2969113 Escherichia coli IAI1 7124633 YP_002388251.1 CDS gudD NC_011741.1 2969345 2970685 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20233700, 9772162, 10762278, 13971911; Product type e : enzyme; (D)-glucarate dehydratase 1 complement(2969345..2970685) Escherichia coli IAI1 7125429 YP_002388252.1 CDS gudX NC_011741.1 2970706 2972046 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9772162; Product type e : enzyme; glucarate dehydratase complement(2970706..2972046) Escherichia coli IAI1 7128480 YP_002388253.1 CDS gudP NC_011741.1 2972048 2973400 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10762278; Product type pt : putative transporter; putative D-glucarate transporter complement(2972048..2973400) Escherichia coli IAI1 7128482 YP_002388254.1 CDS yqcA NC_011741.1 2973835 2974284 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(2973835..2974284) Escherichia coli IAI1 7128481 YP_002388255.1 CDS truC NC_011741.1 2974302 2975084 R catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C complement(2974302..2975084) Escherichia coli IAI1 7124342 YP_002388256.1 CDS yqcC NC_011741.1 2975084 2975413 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2975084..2975413) Escherichia coli IAI1 7127504 YP_002388257.1 CDS syd NC_011741.1 2976035 2976580 R putative SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd complement(2976035..2976580) Escherichia coli IAI1 7126853 YP_002388258.1 CDS queF NC_011741.1 2976648 2977496 D catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 2976648..2977496 Escherichia coli IAI1 7126204 YP_002388259.1 CDS ygdH NC_011741.1 2977608 2978972 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2977608..2978972 Escherichia coli IAI1 7126584 YP_002388260.1 CDS sdaC NC_011741.1 2979529 2980818 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8752353, 8026499; Product type pt : putative transporter; putative serine transporter 2979529..2980818 Escherichia coli IAI1 7124886 YP_002388261.1 CDS sdaB NC_011741.1 2980876 2982243 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91193203, 93215657, 8385012; Product type e : enzyme; L-serine deaminase II 2980876..2982243 Escherichia coli IAI1 7124685 YP_002388262.1 CDS xni NC_011741.1 2982265 2983110 D has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 2982265..2983110 Escherichia coli IAI1 7124684 YP_002388263.1 CDS fucO NC_011741.1 2983165 2984316 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 89291720, 2553671, 2661535, 2664711, 8385012; Product type e : enzyme; L-1,2-propanediol oxidoreductase complement(2983165..2984316) Escherichia coli IAI1 7127048 YP_002388264.1 CDS fucA NC_011741.1 2984341 2984988 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase complement(2984341..2984988) Escherichia coli IAI1 7128248 YP_002388265.1 CDS fucP NC_011741.1 2985535 2986851 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 90036697, 2553671, 2664711, 7783647; Product type t : transporter; L-fucose transporter 2985535..2986851 Escherichia coli IAI1 7128245 YP_002388266.1 CDS fucI NC_011741.1 2986884 2988659 D catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 2986884..2988659 Escherichia coli IAI1 7128249 YP_002388267.1 CDS fucK NC_011741.1 2988738 2990186 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 90036697, 2664711, 13905785; Product type e : enzyme; L-fuculokinase 2988738..2990186 Escherichia coli IAI1 7128246 YP_002388268.1 CDS fucU NC_011741.1 2990188 2990610 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15060078, 12738765, 80049526, 2664711; Product type e : enzyme; L-fucose mutarotase 2990188..2990610 Escherichia coli IAI1 7128247 YP_002388269.1 CDS fucR NC_011741.1 2990668 2991399 D regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 2990668..2991399 Escherichia coli IAI1 7128251 YP_002388270.1 CDS ygdE NC_011741.1 2991443 2992543 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 21188420, 7704273; Product type pe : putative enzyme; putative RNA 2'-O-ribose methyltransferase complement(2991443..2992543) Escherichia coli IAI1 7128250 YP_002388271.1 CDS ygdD NC_011741.1 2992536 2992931 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7704273; Product type pm : putative membrane component; hypothetical protein complement(2992536..2992931) Escherichia coli IAI1 7124885 YP_002388272.1 CDS gcvA NC_011741.1 2992950 2993867 R Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA complement(2992950..2993867) Escherichia coli IAI1 7124884 YP_002388273.1 CDS ygdI NC_011741.1 2994218 2994445 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2994218..2994445) Escherichia coli IAI1 7128295 YP_002388274.1 CDS csdA NC_011741.1 2994637 2995842 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15148362, 9278392, 10739946, 10829016; Product type e : enzyme; cysteine sulfinate desulfinase 2994637..2995842 Escherichia coli IAI1 7124887 YP_002388275.1 CDS ygdK NC_011741.1 2995842 2996285 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative Fe-S metabolism protein 2995842..2996285 Escherichia coli IAI1 7125921 YP_002388276.1 CDS ygdL NC_011741.1 2996336 2997142 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2996336..2997142) Escherichia coli IAI1 7124888 YP_002388277.1 CDS mltA NC_011741.1 2997381 2998478 R membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A complement(2997381..2998478) Escherichia coli IAI1 7124889 YP_002388278.1 CDS ECIAI1_2924 NC_011741.1 2998852 2999043 R hypothetical protein complement(2998852..2999043) Escherichia coli IAI1 7128002 YP_002388279.1 CDS amiC NC_011741.1 2999058 3000311 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12787347, 21348478; Product type e : enzyme; N-acetylmuramoyl-L-alanine amidase complement(2999058..3000311) Escherichia coli IAI1 7128003 YP_002388280.1 CDS argA NC_011741.1 3000543 3001874 D catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 3000543..3001874 Escherichia coli IAI1 7125754 YP_002388281.1 CDS recD NC_011741.1 3001936 3003762 R helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha complement(3001936..3003762) Escherichia coli IAI1 7125786 YP_002388282.1 CDS recB NC_011741.1 3003762 3007304 R helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta complement(3003762..3007304) Escherichia coli IAI1 7124948 YP_002388283.1 CDS ptr NC_011741.1 3007297 3010185 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91193232, 1570301, 3308636, 3534791, 3537960, 8099278; Product type e : enzyme; protease III complement(3007297..3010185) Escherichia coli IAI1 7124946 YP_002388284.1 CDS recC NC_011741.1 3010361 3013729 R catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma complement(3010361..3013729) Escherichia coli IAI1 7126536 YP_002388285.1 CDS ppdC NC_011741.1 3013742 3014065 R Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein complement(3013742..3014065) Escherichia coli IAI1 7124947 YP_002388286.1 CDS ygdB NC_011741.1 3014050 3014457 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3014050..3014457) Escherichia coli IAI1 7126128 YP_002388287.1 CDS ppdB NC_011741.1 3014454 3015017 R Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein complement(3014454..3015017) Escherichia coli IAI1 7124883 YP_002388288.1 CDS ppdA NC_011741.1 3015008 3015478 R Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein complement(3015008..3015478) Escherichia coli IAI1 7126127 YP_002388289.1 CDS thyA NC_011741.1 3015663 3016457 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(3015663..3016457) Escherichia coli IAI1 7126126 YP_002388290.1 CDS lgt NC_011741.1 3016464 3017339 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(3016464..3017339) Escherichia coli IAI1 7126257 YP_002388291.1 CDS ptsP NC_011741.1 3017490 3019736 R member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain-containing protein complement(3017490..3019736) Escherichia coli IAI1 7126416 YP_002388292.1 CDS nudH NC_011741.1 3019749 3020279 R hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase complement(3019749..3020279) Escherichia coli IAI1 7126543 YP_002388293.1 CDS mutH NC_011741.1 3020964 3021653 D MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 3020964..3021653 Escherichia coli IAI1 7125957 YP_002388294.1 CDS ygdQ NC_011741.1 3021722 3022435 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3021722..3022435 Escherichia coli IAI1 7124502 YP_002388295.1 CDS ygdR NC_011741.1 3022573 3022791 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3022573..3022791 Escherichia coli IAI1 7124890 YP_002388296.1 CDS tas NC_011741.1 3022899 3023939 D complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; putative aldo-keto reductase 3022899..3023939 Escherichia coli IAI1 7124891 YP_002388297.1 CDS ygeD NC_011741.1 3023971 3025164 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8300626; Product type pm : putative membrane component; lysophospholipid transporter LplT complement(3023971..3025164) Escherichia coli IAI1 7126213 YP_002388298.1 CDS aas NC_011741.1 3025157 3027316 R Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase complement(3025157..3027316) Escherichia coli IAI1 7124893 YP_002388299.1 CDS galR NC_011741.1 3027902 3028933 D controls transcription of galETKM; DNA-binding transcriptional regulator GalR 3027902..3028933 Escherichia coli IAI1 7125988 YP_002388300.1 CDS lysA NC_011741.1 3028940 3030202 R catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase complement(3028940..3030202) Escherichia coli IAI1 7128273 YP_002388301.1 CDS lysR NC_011741.1 3030324 3031259 D activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; DNA-binding transcriptional regulator LysR 3030324..3031259 Escherichia coli IAI1 7127642 YP_002388302.1 CDS ygeA NC_011741.1 3031246 3031938 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15135544; Product type pe : putative enzyme; putative racemase complement(3031246..3031938) Escherichia coli IAI1 7127645 YP_002388303.1 CDS araE NC_011741.1 3032067 3033485 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7030324, 90239116, 91154204, 2836407, 3543693, 6319708; Product type t : transporter; arabinose transporter complement(3032067..3033485) Escherichia coli IAI1 7124892 YP_002388304.1 CDS kduD NC_011741.1 3033800 3034561 R catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase complement(3033800..3034561) Escherichia coli IAI1 7125779 YP_002388305.1 CDS kduI NC_011741.1 3034591 3035427 R 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase complement(3034591..3035427) Escherichia coli IAI1 7126383 YP_002388306.1 CDS yqeF NC_011741.1 3035714 3036895 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase complement(3035714..3036895) Escherichia coli IAI1 7126384 YP_002388307.1 CDS yqeG NC_011741.1 3037150 3038379 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3037150..3038379 Escherichia coli IAI1 7124348 YP_002388308.1 CDS yqeH NC_011741.1 3038839 3039471 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3038839..3039471 Escherichia coli IAI1 7124349 YP_002388309.1 CDS yqeI NC_011741.1 3039805 3040614 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3039805..3040614 Escherichia coli IAI1 7124350 YP_002388310.1 CDS yqeJ NC_011741.1 3040607 3041089 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3040607..3041089 Escherichia coli IAI1 7124351 YP_002388311.1 CDS yqeK NC_011741.1 3041238 3041663 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3041238..3041663) Escherichia coli IAI1 7124352 YP_002388312.1 CDS ygeF NC_011741.1 3041857 3042294 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3041857..3042294 Escherichia coli IAI1 7128562 YP_002388313.1 CDS ygeG NC_011741.1 3042572 3043063 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative chaperone 3042572..3043063 Escherichia coli IAI1 7124894 YP_002388314.1 CDS ygeH NC_011741.1 3043398 3044774 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15150243; Product type pr : putative regulator; transcriptional regulator 3043398..3044774 Escherichia coli IAI1 7124895 YP_002388315.1 CDS ygeI NC_011741.1 3044942 3045160 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3044942..3045160 Escherichia coli IAI1 7124896 YP_002388316.1 CDS ECIAI1_2966 NC_011741.1 3045243 3045719 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidoglycan-binding-like protein 3045243..3045719 Escherichia coli IAI1 7124897 YP_002388317.1 CDS ECIAI1_2970 NC_011741.1 3047265 3047846 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12791847; hypothetical protein complement(3047265..3047846) Escherichia coli IAI1 7124898 YP_002388318.1 CDS eprK NC_011741.1 3047862 3048596 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12791847; Product type pm : putative membrane component; putative Type III secretion system lipoprotein EprK complement(3047862..3048596) Escherichia coli IAI1 7128566 YP_002388319.1 CDS eprI NC_011741.1 3049029 3049184 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12791847; Product type pt : putative transporter; putative Type III secretion EprI protein complement(3049029..3049184) Escherichia coli IAI1 7128567 YP_002388320.1 CDS eprH NC_011741.1 3049198 3050388 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative Type III secretion EprH protein complement(3049198..3050388) Escherichia coli IAI1 7125081 YP_002388321.1 CDS ECIAI1_2975 NC_011741.1 3050637 3051137 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12791847; hypothetical protein 3050637..3051137 Escherichia coli IAI1 7125080 YP_002388322.1 CDS ECIAI1_2976 NC_011741.1 3051139 3051432 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12791847; hypothetical protein 3051139..3051432 Escherichia coli IAI1 7128568 YP_002388323.1 CDS ECIAI1_2979 NC_011741.1 3052623 3053390 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12791847; Product type pm : putative membrane component; putative Type III secretion protein EpaR complement(3052623..3053390) Escherichia coli IAI1 7127953 YP_002388324.1 CDS spaP NC_011741.1 3053662 3054327 R part of a type III secretory system probably involved in invasion into eukaryotic cells; surface presentation of antigens protein SpaP complement(3053662..3054327) Escherichia coli IAI1 7127951 YP_002388325.1 CDS ECIAI1_2983 NC_011741.1 3055396 3057048 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3055396..3057048) Escherichia coli IAI1 7125078 YP_002388326.1 CDS ygeR NC_011741.1 3057392 3058147 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15150243; Product type r : regulator; Tetratricopeptide repeat transcriptional regulator complement(3057392..3058147) Escherichia coli IAI1 7128040 YP_002388327.1 CDS ECIAI1_2985 NC_011741.1 3058144 3058356 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3058144..3058356) Escherichia coli IAI1 7124899 YP_002388328.1 CDS xdhA NC_011741.1 3058601 3060859 D putative molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 3058601..3060859 Escherichia coli IAI1 7128573 YP_002388329.1 CDS xdhB NC_011741.1 3060870 3061748 D FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 3060870..3061748 Escherichia coli IAI1 7126467 YP_002388330.1 CDS xdhC NC_011741.1 3061745 3062224 D iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 3061745..3062224 Escherichia coli IAI1 7126468 YP_002388331.1 CDS ygeV NC_011741.1 3062264 3064042 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3062264..3064042) Escherichia coli IAI1 7126469 YP_002388332.1 CDS ygeW NC_011741.1 3064518 3065708 D Evidence 4 : Homologs of previously reported genes of unknown function; aspartate/ornithine carbamoyltransferase family protein 3064518..3065708 Escherichia coli IAI1 7124900 YP_002388333.1 CDS ygeX NC_011741.1 3065766 3066962 D catalyzes the formation of pyruvate from 2,3-diaminopropionate; diaminopropionate ammonia-lyase 3065766..3066962 Escherichia coli IAI1 7124901 YP_002388334.1 CDS ygeY NC_011741.1 3067020 3068231 D Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases; peptidase 3067020..3068231 Escherichia coli IAI1 7124902 YP_002388335.1 CDS hyuA NC_011741.1 3068284 3069669 D catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; phenylhydantoinase 3068284..3069669 Escherichia coli IAI1 7124903 YP_002388336.1 CDS yqeA NC_011741.1 3069717 3070649 D catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 3069717..3070649 Escherichia coli IAI1 7126035 YP_002388337.1 CDS yqeB NC_011741.1 3070690 3072315 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3070690..3072315) Escherichia coli IAI1 7124345 YP_002388338.1 CDS yqeC NC_011741.1 3072363 3073133 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3072363..3073133) Escherichia coli IAI1 7124346 YP_002388339.1 CDS ygfJ NC_011741.1 3073236 3073814 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3073236..3073814 Escherichia coli IAI1 7124347 YP_002388340.1 CDS ygfK NC_011741.1 3074136 3077234 D with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase; putative selenate reductase subunit YgfK 3074136..3077234 Escherichia coli IAI1 7124910 YP_002388341.1 CDS ssnA NC_011741.1 3077237 3078565 D in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS; putative chlorohydrolase/aminohydrolase 3077237..3078565 Escherichia coli IAI1 7124911 YP_002388342.1 CDS ygfM NC_011741.1 3078616 3079395 D with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain; putative selenate reductase subunit YgfM 3078616..3079395 Escherichia coli IAI1 7127982 YP_002388343.1 CDS xdhD NC_011741.1 3079392 3082262 D with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration; putative selenate reductase subunit YgfN 3079392..3082262 Escherichia coli IAI1 7124912 YP_002388344.1 CDS ygfO NC_011741.1 3082427 3083827 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20372655, 98213740; Product type pt : putative transporter; putative transporter 3082427..3083827 Escherichia coli IAI1 7126470 YP_002388345.1 CDS guaD NC_011741.1 3083842 3085161 D Catalyzes the deamination of guanine; guanine deaminase 3083842..3085161 Escherichia coli IAI1 7124913 YP_002388346.1 CDS ygfQ NC_011741.1 3085197 3086564 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3085197..3086564 Escherichia coli IAI1 7128479 YP_002388347.1 CDS ygfS NC_011741.1 3086600 3087088 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative oxidoreductase complement(3086600..3087088) Escherichia coli IAI1 7124914 YP_002388348.1 CDS ygfT NC_011741.1 3087088 3089007 R unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); putative oxidoreductase Fe-S binding subunit complement(3087088..3089007) Escherichia coli IAI1 7124915 YP_002388349.1 CDS ygfU NC_011741.1 3089443 3090891 D Evidence 2b : Function of strongly homologous gene; PubMedId : 9098051; Product type t : transporter; transporter 3089443..3090891 Escherichia coli IAI1 7124916 YP_002388350.1 CDS idi NC_011741.1 3091141 3091689 D catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 3091141..3091689 Escherichia coli IAI1 7124917 YP_002388351.1 CDS lysS NC_011741.1 3091732 3093249 R class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(3091732..3093249) Escherichia coli IAI1 7126045 YP_002388352.1 CDS prfB NC_011741.1 3093259 3094357 R recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 complement(join(3093259..3094281,3094283..3094357)) Escherichia coli IAI1 7127646 YP_002388353.1 CDS recJ NC_011741.1 3094448 3096181 R 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ complement(3094448..3096181) Escherichia coli IAI1 7126145 YP_002388354.1 CDS dsbC NC_011741.1 3096187 3096897 R DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC complement(3096187..3096897) Escherichia coli IAI1 7124951 YP_002388355.1 CDS xerD NC_011741.1 3096922 3097818 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD complement(3096922..3097818) Escherichia coli IAI1 7124624 YP_002388356.1 CDS fldB NC_011741.1 3097930 3098451 D An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 3097930..3098451 Escherichia coli IAI1 7126472 YP_002388357.1 CDS ygfX NC_011741.1 3098491 3098898 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3098491..3098898) Escherichia coli IAI1 7127210 YP_002388358.1 CDS ygfY NC_011741.1 3098879 3099145 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3098879..3099145) Escherichia coli IAI1 7124918 YP_002388359.1 CDS ygfZ NC_011741.1 3099388 3100368 D physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; putative global regulator 3099388..3100368 Escherichia coli IAI1 7124919 YP_002388360.1 CDS yqfA NC_011741.1 3100564 3101223 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative hemolysin, inner membrane subunit complement(3100564..3101223) Escherichia coli IAI1 7124920 YP_002388361.1 CDS yqfB NC_011741.1 3101387 3101698 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3101387..3101698) Escherichia coli IAI1 7124354 YP_002388362.1 CDS bglA NC_011741.1 3101737 3103176 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 88297127, 92334140; Product type e : enzyme; 6-phospho-beta-glucosidase A 3101737..3103176 Escherichia coli IAI1 7124355 YP_002388363.1 CDS ygfF NC_011741.1 3103233 3103976 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(3103233..3103976) Escherichia coli IAI1 7124400 YP_002388364.1 CDS gcvP NC_011741.1 3104242 3107115 R acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase complement(3104242..3107115) Escherichia coli IAI1 7124906 YP_002388365.1 CDS gcvH NC_011741.1 3107234 3107623 R part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H complement(3107234..3107623) Escherichia coli IAI1 7128297 YP_002388366.1 CDS gcvT NC_011741.1 3107647 3108741 R catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T complement(3107647..3108741) Escherichia coli IAI1 7128296 YP_002388367.1 CDS visC NC_011741.1 3109188 3110390 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1339425; Product type pe : putative enzyme; hypothetical protein complement(3109188..3110390) Escherichia coli IAI1 7128299 YP_002388368.1 CDS ubiH NC_011741.1 3110413 3111591 R Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase complement(3110413..3111591) Escherichia coli IAI1 7125570 YP_002388369.1 CDS pepP NC_011741.1 3111588 3112913 R exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II complement(3111588..3112913) Escherichia coli IAI1 7125516 YP_002388370.1 CDS ygfB NC_011741.1 3112939 3113517 R the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein complement(3112939..3113517) Escherichia coli IAI1 7124174 YP_002388371.1 CDS zapA NC_011741.1 3113685 3114014 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 412171; Product type cp : cell process; Z-ring-associated protein 3113685..3114014 Escherichia coli IAI1 7124905 YP_002388372.1 CDS ECIAI1_3030 NC_011741.1 3113964 3114290 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3113964..3114290) Escherichia coli IAI1 7128123 YP_002388373.1 CDS ygfA NC_011741.1 3114314 3114862 D ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function; putative ligase 3114314..3114862 Escherichia coli IAI1 7127986 YP_002388374.1 CDS serA NC_011741.1 3115643 3116875 R catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase complement(3115643..3116875) Escherichia coli IAI1 7125500 YP_002388375.1 CDS rpiA NC_011741.1 3117131 3117790 R Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A complement(3117131..3117790) Escherichia coli IAI1 7127908 YP_002388376.1 CDS yqfE NC_011741.1 3117846 3118076 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3117846..3118076) Escherichia coli IAI1 7128617 YP_002388377.1 CDS argP NC_011741.1 3118218 3119111 D specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 3118218..3119111 Escherichia coli IAI1 7124356 YP_002388378.1 CDS yliK NC_011741.1 3119315 3121459 D MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 3119315..3121459 Escherichia coli IAI1 7125796 YP_002388379.1 CDS argK NC_011741.1 3121452 3122447 D functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 3121452..3122447 Escherichia coli IAI1 7126670 YP_002388380.1 CDS ygfG NC_011741.1 3122458 3123243 D catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA; methylmalonyl-CoA decarboxylase 3122458..3123243 Escherichia coli IAI1 7125794 YP_002388381.1 CDS ygfH NC_011741.1 3123267 3124745 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20233703; Product type e : enzyme; propionyl-CoA:succinate-CoA transferase 3123267..3124745 Escherichia coli IAI1 7124907 YP_002388382.1 CDS ygfI NC_011741.1 3124742 3125638 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3124742..3125638) Escherichia coli IAI1 7124908 YP_002388383.1 CDS yggE NC_011741.1 3125805 3126545 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3125805..3126545) Escherichia coli IAI1 7124909 YP_002388384.1 CDS argO NC_011741.1 3126638 3127273 R Involved in the export of arginine; arginine exporter protein complement(3126638..3127273) Escherichia coli IAI1 7124923 YP_002388385.1 CDS mscS NC_011741.1 3127412 3128272 R participates in the regulation of osmotic pressure changes within the cel; mechanosensitive channel MscS complement(3127412..3128272) Escherichia coli IAI1 7125795 YP_002388386.1 CDS fbaA NC_011741.1 3128630 3129709 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase complement(3128630..3129709) Escherichia coli IAI1 7124480 YP_002388387.1 CDS pgk NC_011741.1 3129924 3131087 R Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase complement(3129924..3131087) Escherichia coli IAI1 7127068 YP_002388388.1 CDS epd NC_011741.1 3131137 3132156 R NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase complement(3131137..3132156) Escherichia coli IAI1 7124186 YP_002388389.1 CDS ECIAI1_3048 NC_011741.1 3132528 3132959 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3132528..3132959 Escherichia coli IAI1 7125079 YP_002388390.1 CDS ECIAI1_3049 NC_011741.1 3132883 3133560 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC-type transport system 3132883..3133560 Escherichia coli IAI1 7128575 YP_002388391.1 CDS ECIAI1_3050 NC_011741.1 3133561 3134268 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC-type transport system 3133561..3134268 Escherichia coli IAI1 7128576 YP_002388392.1 CDS ECIAI1_3051 NC_011741.1 3134250 3134933 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 3134250..3134933 Escherichia coli IAI1 7128577 YP_002388393.1 CDS ECIAI1_3052 NC_011741.1 3134894 3135604 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 3134894..3135604 Escherichia coli IAI1 7128578 YP_002388394.1 CDS frcK NC_011741.1 3135576 3136289 R Evidence 4 : Homologs of previously reported genes of unknown function; putative fructose transport system kinase complement(3135576..3136289) Escherichia coli IAI1 7128579 YP_002388395.1 CDS yggD NC_011741.1 3136286 3136795 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3136286..3136795) Escherichia coli IAI1 7124921 YP_002388396.1 CDS yggF NC_011741.1 3136817 3137782 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; fructose-1,6-bisphosphatase II-like protein complement(3136817..3137782) Escherichia coli IAI1 7124922 YP_002388397.1 CDS cmtA NC_011741.1 3139072 3140460 R Evidence 2b : Function of strongly homologous gene; PubMedId : 8353127; Product type t : transporter; PTS system mannitol-specific transporter subunit IIBC complement(3139072..3140460) Escherichia coli IAI1 7124932 YP_002388398.1 CDS cmtB NC_011741.1 3140488 3140931 R TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein; putative mannitol phosphotransferase subunit EIIA complement(3140488..3140931) Escherichia coli IAI1 7126340 YP_002388399.1 CDS tktA NC_011741.1 3141245 3143236 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(3141245..3143236) Escherichia coli IAI1 7126341 YP_002388400.1 CDS yggG NC_011741.1 3143514 3144272 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1310091; Product type pe : putative enzyme; putative peptidase 3143514..3144272 Escherichia coli IAI1 7127451 YP_002388401.1 CDS ECIAI1_3062 NC_011741.1 3144328 3145080 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3144328..3145080) Escherichia coli IAI1 7124925 YP_002388402.1 CDS ECIAI1_3063 NC_011741.1 3145058 3146167 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transferase complement(3145058..3146167) Escherichia coli IAI1 7128580 YP_002388403.1 CDS ECIAI1_3064 NC_011741.1 3146171 3147028 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; mannose permease IID component complement(3146171..3147028) Escherichia coli IAI1 7128581 YP_002388404.1 CDS ECIAI1_3065 NC_011741.1 3147028 3147777 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system enzyme IIC complement(3147028..3147777) Escherichia coli IAI1 7128582 YP_002388405.1 CDS ECIAI1_3066 NC_011741.1 3147803 3148288 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative PTS system protein complement(3147803..3148288) Escherichia coli IAI1 7128583 YP_002388406.1 CDS ECIAI1_3067 NC_011741.1 3148299 3148727 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system enzyme IIA complement(3148299..3148727) Escherichia coli IAI1 7128584 YP_002388407.1 CDS ECIAI1_3068 NC_011741.1 3148846 3151686 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative NtrC family transcriptional regulators, ATPase domain complement(3148846..3151686) Escherichia coli IAI1 7128585 YP_002388408.1 CDS speB NC_011741.1 3151903 3152823 R catalyzes the formation of putrescine from agmatine; agmatinase complement(3151903..3152823) Escherichia coli IAI1 7128586 YP_002388409.1 CDS ECIAI1_3070 NC_011741.1 3152959 3153690 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3152959..3153690) Escherichia coli IAI1 7127955 YP_002388410.1 CDS speA NC_011741.1 3153836 3155812 R catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase complement(3153836..3155812) Escherichia coli IAI1 7128587 YP_002388411.1 CDS yqgB NC_011741.1 3155821 3155967 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3155821..3155967) Escherichia coli IAI1 7127954 YP_002388412.1 CDS yqgC NC_011741.1 3156088 3156303 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3156088..3156303 Escherichia coli IAI1 7124358 YP_002388413.1 CDS yqgD NC_011741.1 3156300 3156551 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3156300..3156551) Escherichia coli IAI1 7124359 YP_002388414.1 CDS metK NC_011741.1 3156607 3157761 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3156607..3157761 Escherichia coli IAI1 7124360 YP_002388415.1 CDS galP NC_011741.1 3158197 3159591 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9182541; Product type t : transporter; D-galactose transporter 3158197..3159591 Escherichia coli IAI1 7124251 YP_002388416.1 CDS sprT NC_011741.1 3159668 3160165 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7984428, 8113204; hypothetical protein 3159668..3160165 Escherichia coli IAI1 7128272 YP_002388417.1 CDS endA NC_011741.1 3160260 3160967 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 72060411, 92335461, 4955462, 7867949, 8113204; Product type e : enzyme; DNA-specific endonuclease I 3160260..3160967 Escherichia coli IAI1 7127965 YP_002388418.1 CDS yggJ NC_011741.1 3161047 3161778 D in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3161047..3161778 Escherichia coli IAI1 7125066 YP_002388419.1 CDS gshB NC_011741.1 3161791 3162741 D catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3161791..3162741 Escherichia coli IAI1 7124927 YP_002388420.1 CDS yqgE NC_011741.1 3162850 3163413 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3162850..3163413 Escherichia coli IAI1 7128472 YP_002388421.1 CDS yqgF NC_011741.1 3163413 3163829 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3163413..3163829 Escherichia coli IAI1 7124361 YP_002388422.1 CDS yggR NC_011741.1 3164005 3164985 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1676385; Product type t : transporter; transporter complement(3164005..3164985) Escherichia coli IAI1 7124362 YP_002388423.1 CDS yggS NC_011741.1 3165003 3165707 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3165003..3165707 Escherichia coli IAI1 7124933 YP_002388424.1 CDS yggT NC_011741.1 3165725 3166291 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3165725..3166291 Escherichia coli IAI1 7124934 YP_002388425.1 CDS yggU NC_011741.1 3166288 3166578 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12975589; hypothetical protein 3166288..3166578 Escherichia coli IAI1 7124935 YP_002388426.1 CDS yggV NC_011741.1 3166586 3167179 D HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 3166586..3167179 Escherichia coli IAI1 7124936 YP_002388427.1 CDS yggW NC_011741.1 3167172 3168308 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3167172..3168308 Escherichia coli IAI1 7124937 YP_002388428.1 CDS yggM NC_011741.1 3168463 3169470 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3168463..3169470) Escherichia coli IAI1 7124938 YP_002388429.1 CDS ansB NC_011741.1 3169587 3170633 R catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II complement(3169587..3170633) Escherichia coli IAI1 7124929 YP_002388430.1 CDS yggN NC_011741.1 3170809 3171528 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein complement(3170809..3171528) Escherichia coli IAI1 7125765 YP_002388431.1 CDS yggL NC_011741.1 3171712 3172038 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3171712..3172038) Escherichia coli IAI1 7124930 YP_002388432.1 CDS trmB NC_011741.1 3172038 3172757 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(3172038..3172757) Escherichia coli IAI1 7124928 YP_002388433.1 CDS mutY NC_011741.1 3172918 3173970 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14730969, 20187555, 20316830, 20580749, 21438845, 90046892, 92409600, 9801309, 2001994, 2197596, 9846876; Product type e : enzyme; adenine DNA glycosylase 3172918..3173970 Escherichia coli IAI1 7124926 YP_002388434.1 CDS yggX NC_011741.1 3173998 3174273 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594836, 10493123, 9298646, 9868784; Product type f : factor; hypothetical protein 3173998..3174273 Escherichia coli IAI1 7124507 YP_002388435.1 CDS mltC NC_011741.1 3174338 3175417 D Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3174338..3175417 Escherichia coli IAI1 7124939 YP_002388436.1 CDS nupG NC_011741.1 3175619 3176875 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88029453, 90323001, 3311747; Product type t : transporter; nucleoside transporter 3175619..3176875 Escherichia coli IAI1 7124283 YP_002388437.1 CDS speC NC_011741.1 3176925 3179060 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 87260820; Product type e : enzyme; ornithine decarboxylase complement(3176925..3179060) Escherichia coli IAI1 7125972 YP_002388438.1 CDS ECIAI1_3099 NC_011741.1 3179222 3179371 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3179222..3179371) Escherichia coli IAI1 7127956 YP_002388439.1 CDS yqgA NC_011741.1 3179458 3180165 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3179458..3180165 Escherichia coli IAI1 7128588 YP_002388440.1 CDS yghD NC_011741.1 3180495 3181031 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative general secretion pathway protein YghD complement(3180495..3181031) Escherichia coli IAI1 7128004 YP_002388441.1 CDS yghE NC_011741.1 3181033 3182211 R similar to general secretory pathway protein L; GspL-like protein complement(3181033..3182211) Escherichia coli IAI1 7124942 YP_002388442.1 CDS ECIAI1_3103 NC_011741.1 3182208 3183185 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative type II secretion protein complement(3182208..3183185) Escherichia coli IAI1 7124943 YP_002388443.1 CDS ECIAI1_3104 NC_011741.1 3183188 3183787 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3183188..3183787) Escherichia coli IAI1 7128589 YP_002388444.1 CDS ECIAI1_3105 NC_011741.1 3183784 3184155 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative type II secretion protein complement(3183784..3184155) Escherichia coli IAI1 7128590 YP_002388445.1 CDS ECIAI1_3106 NC_011741.1 3184152 3184715 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3184152..3184715) Escherichia coli IAI1 7128591 YP_002388446.1 CDS ECIAI1_3107 NC_011741.1 3184719 3185201 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative general secretion pathway protein G complement(3184719..3185201) Escherichia coli IAI1 7128592 YP_002388447.1 CDS epsF NC_011741.1 3185191 3186414 R Evidence 2b : Function of strongly homologous gene; Product type t : transporter; General secretion pathway protein F complement(3185191..3186414) Escherichia coli IAI1 7128593 YP_002388448.1 CDS epsE NC_011741.1 3186414 3187907 R Evidence 2b : Function of strongly homologous gene; Product type t : transporter; general secretion pathway protein E complement(3186414..3187907) Escherichia coli IAI1 7125085 YP_002388449.1 CDS epsD NC_011741.1 3187907 3189967 R Evidence 2b : Function of strongly homologous gene; Product type t : transporter; general secretion pathway protein D complement(3187907..3189967) Escherichia coli IAI1 7125084 YP_002388450.1 CDS yghF NC_011741.1 3189997 3190956 R part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm; putative type II secretion protein GspC complement(3189997..3190956) Escherichia coli IAI1 7125083 YP_002388451.1 CDS yghG NC_011741.1 3190974 3191384 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3190974..3191384) Escherichia coli IAI1 7124944 YP_002388452.1 CDS pppA NC_011741.1 3191450 3192259 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98175453; Product type e : enzyme; bifunctional prepilin leader peptidase and methylase complement(3191450..3192259) Escherichia coli IAI1 7124945 YP_002388453.1 CDS yghJ NC_011741.1 3192399 3196976 R Evidence 2b : Function of strongly homologous gene; PubMedId : 1644747; Product type lp : lipoprotein; inner membrane lipoprotein complement(3192399..3196976) Escherichia coli IAI1 7126137 YP_002388454.1 CDS ECIAI1_3115 NC_011741.1 3197124 3197309 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3197124..3197309 Escherichia coli IAI1 7128607 YP_002388455.1 CDS yghK NC_011741.1 3197461 3199143 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11785976, 21178909, 11283302; Product type t : transporter; glycolate transporter complement(3197461..3199143) Escherichia coli IAI1 7128594 YP_002388456.1 CDS glcB NC_011741.1 3199499 3201670 R catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G complement(3199499..3201670) Escherichia coli IAI1 7124436 YP_002388457.1 CDS glcG NC_011741.1 3201692 3202096 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3201692..3202096) Escherichia coli IAI1 7128304 YP_002388458.1 CDS glcF NC_011741.1 3202101 3203324 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type c : carrier; glycolate oxidase iron-sulfur subunit complement(3202101..3203324) Escherichia coli IAI1 7128309 YP_002388459.1 CDS glcE NC_011741.1 3203335 3204387 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type e : enzyme; glycolate oxidase FAD binding subunit complement(3203335..3204387) Escherichia coli IAI1 7128308 YP_002388460.1 CDS glcD NC_011741.1 3204387 3205886 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type e : enzyme; glycolate oxidase subunit GlcD complement(3204387..3205886) Escherichia coli IAI1 7128307 YP_002388461.1 CDS glcC NC_011741.1 3206137 3206901 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 9880556, 8606183; Product type r : regulator; DNA-binding transcriptional regulator GlcC 3206137..3206901 Escherichia coli IAI1 7128306 YP_002388462.1 CDS yghO NC_011741.1 3206908 3208050 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3206908..3208050) Escherichia coli IAI1 7128305 YP_002388463.1 CDS ECIAI1_3125 NC_011741.1 3209929 3211053 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative epimerase 3209929..3211053 Escherichia coli IAI1 7128595 YP_002388464.1 CDS ECIAI1_3126 NC_011741.1 3211085 3211333 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3211085..3211333 Escherichia coli IAI1 7128596 YP_002388465.1 CDS ECIAI1_3127 NC_011741.1 3211333 3212505 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 8-amino-7-oxononanoate synthase 3211333..3212505 Escherichia coli IAI1 7128597 YP_002388466.1 CDS ECIAI1_3128 NC_011741.1 3212541 3213701 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3212541..3213701) Escherichia coli IAI1 7128598 YP_002388467.1 CDS ECIAI1_3129 NC_011741.1 3213617 3214687 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3213617..3214687) Escherichia coli IAI1 7128599 YP_002388468.1 CDS ECIAI1_3130 NC_011741.1 3214718 3215281 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator complement(3214718..3215281) Escherichia coli IAI1 7128600 YP_002388469.1 CDS ECIAI1_3131 NC_011741.1 3215290 3216114 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3215290..3216114) Escherichia coli IAI1 7128601 YP_002388470.1 CDS ECIAI1_3132 NC_011741.1 3216114 3217463 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein complement(3216114..3217463) Escherichia coli IAI1 7128602 YP_002388471.1 CDS yghR NC_011741.1 3217509 3218267 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3217509..3218267) Escherichia coli IAI1 7128603 YP_002388472.1 CDS yghS NC_011741.1 3218299 3219012 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3218299..3219012) Escherichia coli IAI1 7128705 YP_002388473.1 CDS yghT NC_011741.1 3219186 3219878 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3219186..3219878 Escherichia coli IAI1 7128706 YP_002388474.1 CDS pitB NC_011741.1 3219927 3221426 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21336523, 21382172, 7775463; Product type t : transporter; phosphate transporter complement(3219927..3221426) Escherichia coli IAI1 7128707 YP_002388475.1 CDS gss NC_011741.1 3221718 3223577 R catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase complement(3221718..3223577) Escherichia coli IAI1 7124378 YP_002388476.1 CDS yghU NC_011741.1 3223782 3224648 D YghU; B2989; one of eight putative glutathione transferase proteins from E. coli; putative glutathione S-transferase YghU 3223782..3224648 Escherichia coli IAI1 7128474 YP_002388477.1 CDS hybG NC_011741.1 3224771 3225019 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 94292472, 8021226; Product type pf : putative factor; hydrogenase 2 accessory protein HypG complement(3224771..3225019) Escherichia coli IAI1 7128708 YP_002388478.1 CDS hybF NC_011741.1 3225032 3225373 R plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF complement(3225032..3225373) Escherichia coli IAI1 7125338 YP_002388479.1 CDS hybE NC_011741.1 3225366 3225854 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94292472, 8021226; Product type f : factor; hydrogenase 2-specific chaperone complement(3225366..3225854) Escherichia coli IAI1 7125337 YP_002388480.1 CDS hybD NC_011741.1 3225847 3226341 R protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase complement(3225847..3226341) Escherichia coli IAI1 7125336 YP_002388481.1 CDS hybC NC_011741.1 3226341 3228044 R involved in hydrogen uptake; hydrogenase 2 large subunit complement(3226341..3228044) Escherichia coli IAI1 7125335 YP_002388482.1 CDS hybB NC_011741.1 3228041 3229219 R HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; putative hydrogenase 2 b cytochrome subunit complement(3228041..3229219) Escherichia coli IAI1 7125334 YP_002388483.1 CDS hybA NC_011741.1 3229209 3230195 R Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA complement(3229209..3230195) Escherichia coli IAI1 7125333 YP_002388484.1 CDS hybO NC_011741.1 3230198 3231316 R involved in hydrogen uptake; hydrogenase 2 small subunit complement(3230198..3231316) Escherichia coli IAI1 7125332 YP_002388485.1 CDS ECIAI1_3147 NC_011741.1 3231323 3231508 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3231323..3231508) Escherichia coli IAI1 7125339 YP_002388486.1 CDS yghW NC_011741.1 3231505 3231792 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3231505..3231792) Escherichia coli IAI1 7128604 YP_002388487.1 CDS ECIAI1_3149 NC_011741.1 3231911 3232843 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3231911..3232843) Escherichia coli IAI1 7128709 YP_002388488.1 CDS yghZ NC_011741.1 3232955 3233995 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12583903; Product type e : enzyme; aldo-keto reductase 3232955..3233995 Escherichia coli IAI1 7128605 YP_002388489.1 CDS yqhA NC_011741.1 3234035 3234529 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3234035..3234529) Escherichia coli IAI1 7128710 YP_002388490.1 CDS yghA NC_011741.1 3234720 3235604 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; oxidoreductase 3234720..3235604 Escherichia coli IAI1 7124363 YP_002388491.1 CDS exbD NC_011741.1 3235876 3236301 R membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD complement(3235876..3236301) Escherichia coli IAI1 7124940 YP_002388492.1 CDS exbB NC_011741.1 3236308 3237042 R membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB complement(3236308..3237042) Escherichia coli IAI1 7127047 YP_002388493.1 CDS ECIAI1_3155 NC_011741.1 3237035 3237190 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3237035..3237190) Escherichia coli IAI1 7127046 YP_002388494.1 CDS metC NC_011741.1 3237294 3238481 D catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3237294..3238481 Escherichia coli IAI1 7128606 YP_002388495.1 CDS yghB NC_011741.1 3238621 3239280 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3238621..3239280 Escherichia coli IAI1 7124244 YP_002388496.1 CDS yqhC NC_011741.1 3239320 3240276 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3239320..3240276) Escherichia coli IAI1 7124941 YP_002388497.1 CDS yqhD NC_011741.1 3240413 3241576 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15327949; Product type e : enzyme; alcohol dehydrogenase 3240413..3241576 Escherichia coli IAI1 7124364 YP_002388498.1 CDS dkgA NC_011741.1 3241681 3242508 D methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3241681..3242508 Escherichia coli IAI1 7124365 YP_002388499.1 CDS yqhG NC_011741.1 3242708 3243634 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3242708..3243634 Escherichia coli IAI1 7124596 YP_002388500.1 CDS yqhH NC_011741.1 3243685 3243942 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative outer membrane lipoprotein 3243685..3243942 Escherichia coli IAI1 7124366 YP_002388501.1 CDS ygiQ NC_011741.1 3243985 3246204 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3243985..3246204) Escherichia coli IAI1 7124367 YP_002388502.1 CDS sufI NC_011741.1 3246315 3247727 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88314889, 1557036, 9298646; Product type r : regulator; repressor protein for FtsI complement(3246315..3247727) Escherichia coli IAI1 7128718 YP_002388503.1 CDS plsC NC_011741.1 3247802 3248539 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92212294, 1557036; Product type e : enzyme; 1-acyl-sn-glycerol-3-phosphate acyltransferase complement(3247802..3248539) Escherichia coli IAI1 7126197 YP_002388504.1 CDS ECIAI1_3167 NC_011741.1 3248587 3248742 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3248587..3248742) Escherichia coli IAI1 7126100 YP_002388505.1 CDS parC NC_011741.1 3248772 3251030 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A complement(3248772..3251030) Escherichia coli IAI1 7126179 YP_002388506.1 CDS ygiV NC_011741.1 3251576 3252058 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator complement(3251576..3252058) Escherichia coli IAI1 7124155 YP_002388507.1 CDS ygiW NC_011741.1 3252111 3252503 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9298646; hypothetical protein complement(3252111..3252503) Escherichia coli IAI1 7128719 YP_002388508.1 CDS qseB NC_011741.1 3252655 3253314 D response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3252655..3253314 Escherichia coli IAI1 7128720 YP_002388509.1 CDS qseC NC_011741.1 3253311 3254660 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21927389; Product type r : regulator; sensor protein QseC 3253311..3254660 Escherichia coli IAI1 7126580 YP_002388510.1 CDS ygiZ NC_011741.1 3254706 3255038 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3254706..3255038) Escherichia coli IAI1 7126581 YP_002388511.1 CDS mdaB NC_011741.1 3255357 3255938 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96004656, 96217538; Product type c : carrier; NADPH quinone reductase 3255357..3255938 Escherichia coli IAI1 7128721 YP_002388512.1 CDS ygiN NC_011741.1 3255969 3256283 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10493123, 9298646, 9600841, 9868784; Product type e : enzyme; quinol monooxygenase 3255969..3256283 Escherichia coli IAI1 7127679 YP_002388513.1 CDS parE NC_011741.1 3256331 3258223 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B complement(3256331..3258223) Escherichia coli IAI1 7128716 YP_002388514.1 CDS yqiA NC_011741.1 3258252 3258833 R Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YqiA complement(3258252..3258833) Escherichia coli IAI1 7124156 YP_002388515.1 CDS cpdA NC_011741.1 3258833 3259660 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96411758; Product type e : enzyme; cyclic 3',5'-adenosine monophosphate phosphodiesterase complement(3258833..3259660) Escherichia coli IAI1 7124368 YP_002388516.1 CDS yqiB NC_011741.1 3259685 3260107 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(3259685..3260107) Escherichia coli IAI1 7126354 YP_002388517.1 CDS nudF NC_011741.1 3260108 3260737 R ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase NudF complement(3260108..3260737) Escherichia coli IAI1 7124369 YP_002388518.1 CDS tolC NC_011741.1 3260942 3262423 D trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3260942..3262423 Escherichia coli IAI1 7125955 YP_002388519.1 CDS ygiB NC_011741.1 3262667 3263242 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3262667..3263242 Escherichia coli IAI1 7127460 YP_002388520.1 CDS ygiC NC_011741.1 3263248 3264408 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3263248..3264408 Escherichia coli IAI1 7128711 YP_002388521.1 CDS zupT NC_011741.1 3264446 3265261 R seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein complement(3264446..3265261) Escherichia coli IAI1 7128712 YP_002388522.1 CDS ygiE NC_011741.1 3265377 3266150 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11790762, 1314093; Product type t : transporter; zinc transporter ZupT 3265377..3266150 Escherichia coli IAI1 7128134 YP_002388523.1 CDS ECIAI1_3188 NC_011741.1 3266208 3266402 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3266208..3266402) Escherichia coli IAI1 7128713 YP_002388524.1 CDS ribB NC_011741.1 3266639 3267292 R DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase complement(3266639..3267292) Escherichia coli IAI1 7125591 YP_002388525.1 CDS ECIAI1_3190 NC_011741.1 3267419 3267493 R hypothetical protein complement(3267419..3267493) Escherichia coli IAI1 7124993 YP_002388526.1 CDS yqiC NC_011741.1 3267666 3267956 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3267666..3267956 Escherichia coli IAI1 7125592 YP_002388527.1 CDS ygiL NC_011741.1 3268239 3268790 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial protein 3268239..3268790 Escherichia coli IAI1 7124370 YP_002388528.1 CDS yqiG NC_011741.1 3268841 3271354 D Evidence 2b : Function of strongly homologous gene; Product type f : factor; outer membrane usher protein 3268841..3271354 Escherichia coli IAI1 7128715 YP_002388529.1 CDS yqiH NC_011741.1 3271370 3272119 D Evidence 2b : Function of strongly homologous gene; Product type f : factor; periplasmic pilin chaperone 3271370..3272119 Escherichia coli IAI1 7124371 YP_002388530.1 CDS yqiI NC_011741.1 3272121 3273185 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3272121..3273185 Escherichia coli IAI1 7124372 YP_002388531.1 CDS glgS NC_011741.1 3273228 3273428 R Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS complement(3273228..3273428) Escherichia coli IAI1 7124373 YP_002388532.1 CDS yqiJ NC_011741.1 3273697 3274326 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3273697..3274326 Escherichia coli IAI1 7128315 YP_002388533.1 CDS yqiK NC_011741.1 3274353 3276014 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3274353..3276014 Escherichia coli IAI1 7124374 YP_002388534.1 CDS rfaE NC_011741.1 3276808 3278241 R catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase complement(3276808..3278241) Escherichia coli IAI1 7125501 YP_002388535.1 CDS glnE NC_011741.1 3278289 3281129 R catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase complement(3278289..3281129) Escherichia coli IAI1 7124962 YP_002388536.1 CDS ygiF NC_011741.1 3281152 3282453 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8412694; Product type pe : putative enzyme; putative adenylate cyclase complement(3281152..3282453) Escherichia coli IAI1 7128324 YP_002388537.1 CDS ECIAI1_3202 NC_011741.1 3282470 3282676 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3282470..3282676) Escherichia coli IAI1 7128714 YP_002388538.1 CDS htrG NC_011741.1 3282695 3283315 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11274153; Product type pr : putative regulator; putative signal transduction protein 3282695..3283315 Escherichia coli IAI1 7125593 YP_002388539.1 CDS cca NC_011741.1 3283379 3284617 D catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3283379..3284617 Escherichia coli IAI1 7125323 YP_002388540.1 CDS bacA NC_011741.1 3284780 3285601 R BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase complement(3284780..3285601) Escherichia coli IAI1 7124455 YP_002388541.1 CDS folB NC_011741.1 3285691 3286059 R catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase complement(3285691..3286059) Escherichia coli IAI1 7126287 YP_002388542.1 CDS plsY NC_011741.1 3286164 3286781 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY 3286164..3286781 Escherichia coli IAI1 7127260 YP_002388543.1 CDS ygiP NC_011741.1 3286794 3287726 R activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol; transcriptional activator TtdR complement(3286794..3287726) Escherichia coli IAI1 7126102 YP_002388544.1 CDS ttdA NC_011741.1 3287933 3288844 D Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 3287933..3288844 Escherichia coli IAI1 7128717 YP_002388545.1 CDS ttdB NC_011741.1 3288841 3289446 D Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 3288841..3289446 Escherichia coli IAI1 7127513 YP_002388546.1 CDS ygjE NC_011741.1 3289494 3290957 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative tartrate:succinate antiporter 3289494..3290957 Escherichia coli IAI1 7127514 YP_002388547.1 CDS gcp NC_011741.1 3291000 3292013 R in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease complement(3291000..3292013) Escherichia coli IAI1 7128722 YP_002388548.1 CDS rpsU NC_011741.1 3292250 3292465 D a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3292250..3292465 Escherichia coli IAI1 7128293 YP_002388549.1 CDS dnaG NC_011741.1 3292576 3294321 D synthesizes RNA primers at the replication forks; DNA primase 3292576..3294321 Escherichia coli IAI1 7128427 YP_002388550.1 CDS rpoD NC_011741.1 3294516 3296357 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3294516..3296357 Escherichia coli IAI1 7124608 YP_002388551.1 CDS ygjF NC_011741.1 3296435 3296941 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20412902, 99453007, 6269063, 7567469, 8878487, 9489705; Product type e : enzyme; G/U mismatch-specific DNA glycosylase complement(3296435..3296941) Escherichia coli IAI1 7128399 YP_002388552.1 CDS yqjH NC_011741.1 3297195 3297959 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative siderophore interacting protein complement(3297195..3297959) Escherichia coli IAI1 7128006 YP_002388553.1 CDS yqjI NC_011741.1 3298236 3298859 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3298236..3298859 Escherichia coli IAI1 7128070 YP_002388554.1 CDS aer NC_011741.1 3299013 3300533 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20015410, 9380671, 9643537, 9190831; Product type r : regulator; signal transducer for aerotaxis sensory protein complement(3299013..3300533) Escherichia coli IAI1 7128071 YP_002388555.1 CDS ygjG NC_011741.1 3300924 3302330 D catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 3300924..3302330 Escherichia coli IAI1 7125725 YP_002388556.1 CDS ygjH NC_011741.1 3302372 3302704 R Evidence 2b : Function of strongly homologous gene; PubMedId : 11101501; hypothetical protein complement(3302372..3302704) Escherichia coli IAI1 7128724 YP_002388557.1 CDS ebgR NC_011741.1 3302923 3303906 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89128452, 2515108, 3939708; Product type r : regulator; DNA-binding transcriptional repressor EbgR 3302923..3303906 Escherichia coli IAI1 7128725 YP_002388558.1 CDS ebgA NC_011741.1 3304090 3307182 D in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 3304090..3307182 Escherichia coli IAI1 7125042 YP_002388559.1 CDS ebgC NC_011741.1 3307179 3307628 D in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 3307179..3307628 Escherichia coli IAI1 7125040 YP_002388560.1 CDS ygjI NC_011741.1 3307691 3309124 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3307691..3309124 Escherichia coli IAI1 7125041 YP_002388561.1 CDS ygjJ NC_011741.1 3309258 3310328 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3309258..3310328 Escherichia coli IAI1 7128726 YP_002388562.1 CDS ygjK NC_011741.1 3310345 3312696 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15213393; Product type pe : putative enzyme; putative glycosyl hydrolase 3310345..3312696 Escherichia coli IAI1 7128727 YP_002388563.1 CDS fadH NC_011741.1 3313022 3315040 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12840019, 89380266; Product type e : enzyme; 2,4-dienoyl-CoA reductase, NADH and FMN-linked 3313022..3315040 Escherichia coli IAI1 7128728 YP_002388564.1 CDS ygjM NC_011741.1 3315085 3315501 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3315085..3315501) Escherichia coli IAI1 7127065 YP_002388565.1 CDS ygjO NC_011741.1 3315771 3316907 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase small domain complement(3315771..3316907) Escherichia coli IAI1 7128729 YP_002388566.1 CDS ygjP NC_011741.1 3316992 3317495 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal dependent hydrolase 3316992..3317495 Escherichia coli IAI1 7128730 YP_002388567.1 CDS ygjQ NC_011741.1 3317572 3318255 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative thioredoxin-like 3317572..3318255 Escherichia coli IAI1 7128731 YP_002388568.1 CDS ygjR NC_011741.1 3318316 3319320 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P)-binding dehydrogenase 3318316..3319320 Escherichia coli IAI1 7128732 YP_002388569.1 CDS alx NC_011741.1 3319603 3320568 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12107143, 2108134; Product type pm : putative membrane component; hypothetical protein 3319603..3320568 Escherichia coli IAI1 7127969 YP_002388570.1 CDS sstT NC_011741.1 3320967 3322211 D involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3320967..3322211 Escherichia coli IAI1 7125751 YP_002388571.1 CDS ygjV NC_011741.1 3322216 3322767 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3322216..3322767) Escherichia coli IAI1 7124863 YP_002388572.1 CDS uxaA NC_011741.1 3322850 3324337 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4570160, 83114543, 3038546; Product type e : enzyme; altronate hydrolase complement(3322850..3324337) Escherichia coli IAI1 7128734 YP_002388573.1 CDS uxaC NC_011741.1 3324352 3325764 R catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase complement(3324352..3325764) Escherichia coli IAI1 7125560 YP_002388574.1 CDS exuT NC_011741.1 3326127 3327545 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83218546, 98190790; Product type t : transporter; hexuronate transporter 3326127..3327545 Escherichia coli IAI1 7125562 YP_002388575.1 CDS ECIAI1_3240 NC_011741.1 3327633 3328721 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3327633..3328721) Escherichia coli IAI1 7127051 YP_002388576.1 CDS ECIAI1_3241 NC_011741.1 3328718 3331420 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3328718..3331420) Escherichia coli IAI1 7125594 YP_002388577.1 CDS ECIAI1_3242 NC_011741.1 3331494 3331994 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative adhesin major subunit pilin complement(3331494..3331994) Escherichia coli IAI1 7125595 YP_002388578.1 CDS ECIAI1_3243 NC_011741.1 3332024 3332740 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial protein complement(3332024..3332740) Escherichia coli IAI1 7125596 YP_002388579.1 CDS exuR NC_011741.1 3333036 3333812 D regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 3333036..3333812 Escherichia coli IAI1 7125597 YP_002388580.1 CDS yqjA NC_011741.1 3334157 3334819 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3334157..3334819 Escherichia coli IAI1 7127050 YP_002388581.1 CDS yqjB NC_011741.1 3334823 3335206 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3334823..3335206 Escherichia coli IAI1 7124376 YP_002388582.1 CDS yqjC NC_011741.1 3335353 3335721 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3335353..3335721 Escherichia coli IAI1 7124377 YP_002388583.1 CDS yqjD NC_011741.1 3335759 3336064 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3335759..3336064 Escherichia coli IAI1 7127906 YP_002388584.1 CDS yqjE NC_011741.1 3336067 3336471 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3336067..3336471 Escherichia coli IAI1 7128066 YP_002388585.1 CDS yqjK NC_011741.1 3336461 3336760 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3336461..3336760 Escherichia coli IAI1 7128067 YP_002388586.1 CDS yqjF NC_011741.1 3336946 3337338 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative quinol oxidase subunit 3336946..3337338 Escherichia coli IAI1 7128072 YP_002388587.1 CDS yqjG NC_011741.1 3337408 3338394 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8478329; Product type e : enzyme; S-transferase 3337408..3338394 Escherichia coli IAI1 7128068 YP_002388588.1 CDS yhaH NC_011741.1 3338687 3339052 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3338687..3339052 Escherichia coli IAI1 7128069 YP_002388589.1 CDS yhaI NC_011741.1 3339294 3339650 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3339294..3339650 Escherichia coli IAI1 7128737 YP_002388590.1 CDS yhaJ NC_011741.1 3339701 3340597 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3339701..3340597) Escherichia coli IAI1 7128738 YP_002388591.1 CDS yhaK NC_011741.1 3340702 3341403 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative pirin-related protein 3340702..3341403 Escherichia coli IAI1 7128739 YP_002388592.1 CDS yhaL NC_011741.1 3341426 3341590 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3341426..3341590 Escherichia coli IAI1 7128740 YP_002388593.1 CDS ECIAI1_3258 NC_011741.1 3341580 3341741 R hypothetical protein complement(3341580..3341741) Escherichia coli IAI1 7128741 YP_002388594.1 CDS yhaM NC_011741.1 3341802 3343112 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3341802..3343112) Escherichia coli IAI1 7125598 YP_002388595.1 CDS yhaO NC_011741.1 3343140 3344408 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(3343140..3344408) Escherichia coli IAI1 7128742 YP_002388596.1 CDS tdcG NC_011741.1 3344746 3346110 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98143432, 9484901; Product type e : enzyme; L-serine dehydratase 3 complement(3344746..3346110) Escherichia coli IAI1 7128743 YP_002388597.1 CDS tdcF NC_011741.1 3346182 3346571 R Evidence 2b : Function of strongly homologous gene; PubMedId : 12777779, 9484901; Product type e : enzyme; hypothetical protein complement(3346182..3346571) Escherichia coli IAI1 7126230 YP_002388598.1 CDS tdcE NC_011741.1 3346585 3348879 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98143432, 9484901; Product type e : enzyme; pyruvate formate-lyase 4/2-ketobutyrate formate-lyase complement(3346585..3348879) Escherichia coli IAI1 7126229 YP_002388599.1 CDS tdcD NC_011741.1 3348913 3350133 R catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase complement(3348913..3350133) Escherichia coli IAI1 7126228 YP_002388600.1 CDS tdcC NC_011741.1 3350147 3351478 R involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC complement(3350147..3351478) Escherichia coli IAI1 7126227 YP_002388601.1 CDS tdcB NC_011741.1 3351500 3352489 R catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase complement(3351500..3352489) Escherichia coli IAI1 7126226 YP_002388602.1 CDS tdcA NC_011741.1 3352588 3353526 R regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA complement(3352588..3353526) Escherichia coli IAI1 7126225 YP_002388603.1 CDS tdcR NC_011741.1 3353703 3354059 D participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 3353703..3354059 Escherichia coli IAI1 7126224 YP_002388604.1 CDS yhaB NC_011741.1 3354315 3354854 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3354315..3354854 Escherichia coli IAI1 7126231 YP_002388605.1 CDS yhaC NC_011741.1 3354876 3356063 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1705543, 2573820, 2660107, 6351058; hypothetical protein 3354876..3356063 Escherichia coli IAI1 7128735 YP_002388606.1 CDS ECIAI1_3271 NC_011741.1 3356124 3356288 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3356124..3356288 Escherichia coli IAI1 7128736 YP_002388607.1 CDS garK NC_011741.1 3356867 3358093 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20225875, 69151449, 9772162; Product type e : enzyme; glycerate kinase I complement(3356867..3358093) Escherichia coli IAI1 7125502 YP_002388608.1 CDS garR NC_011741.1 3358109 3358999 R catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase complement(3358109..3358999) Escherichia coli IAI1 7128280 YP_002388609.1 CDS garL NC_011741.1 3359029 3359799 R cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase complement(3359029..3359799) Escherichia coli IAI1 7128283 YP_002388610.1 CDS garP NC_011741.1 3359815 3361149 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10762278, 9772162; Product type pt : putative transporter; putative (D)-galactarate transporter complement(3359815..3361149) Escherichia coli IAI1 7128281 YP_002388611.1 CDS garD NC_011741.1 3361524 3363095 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20225875, 66096392, 81027430, 9772162, 10762278, 2407727; Product type e : enzyme; (D)-galactarate dehydrogenase 3361524..3363095 Escherichia coli IAI1 7128282 YP_002388612.1 CDS sohA NC_011741.1 3363244 3363579 D SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation; putative regulator PrlF 3363244..3363579 Escherichia coli IAI1 7128279 YP_002388613.1 CDS yhaV NC_011741.1 3363579 3364043 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3363579..3364043 Escherichia coli IAI1 7127944 YP_002388614.1 CDS agaR NC_011741.1 3364098 3364907 R transcriptional repressor for the agaZVWA and agaSYBCDI operons; DNA-binding transcriptional regulator AgaR complement(3364098..3364907) Escherichia coli IAI1 7128744 YP_002388615.1 CDS kbaZ NC_011741.1 3365156 3366436 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976750, 20392444, 10931310, 8932697; Product type e : enzyme; tagatose 6-phosphate aldolase 1, kbaZ subunit 3365156..3366436 Escherichia coli IAI1 7125732 YP_002388616.1 CDS agaV NC_011741.1 3366459 3366932 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3366459..3366932 Escherichia coli IAI1 7126095 YP_002388617.1 CDS ECIAI1_3282 NC_011741.1 3366943 3367722 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative PTS system transporter subunit IIC 3366943..3367722 Escherichia coli IAI1 7125734 YP_002388618.1 CDS ECIAI1_3283 NC_011741.1 3367706 3368590 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative hexose/hexosamine family PTS permease IID component 3367706..3368590 Escherichia coli IAI1 7125600 YP_002388619.1 CDS ECIAI1_3284 NC_011741.1 3368608 3369042 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system enzyme subunit (N-acetyl-galactosamine / galactosamine PTS system enzyme IIA component) 3368608..3369042 Escherichia coli IAI1 7125601 YP_002388620.1 CDS agaA NC_011741.1 3369018 3370172 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; N-acetylglucosamine-6-phosphate deacetylase 3369018..3370172 Escherichia coli IAI1 7125602 YP_002388621.1 CDS agaS NC_011741.1 3370523 3371677 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689210, 9697096, 14731281, 8932697; Product type e : enzyme; tagatose-6-phosphate ketose/aldose isomerase 3370523..3371677 Escherichia coli IAI1 7125727 YP_002388622.1 CDS kbaY NC_011741.1 3371690 3372550 D catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 3371690..3372550 Escherichia coli IAI1 7125733 YP_002388623.1 CDS agaB NC_011741.1 3372717 3373193 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3372717..3373193 Escherichia coli IAI1 7126094 YP_002388624.1 CDS agaC NC_011741.1 3373232 3374035 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIC 3373232..3374035 Escherichia coli IAI1 7125728 YP_002388625.1 CDS agaD NC_011741.1 3374025 3374816 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IID 3374025..3374816 Escherichia coli IAI1 7125729 YP_002388626.1 CDS agaI NC_011741.1 3374817 3375572 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10931310; Product type e : enzyme; galactosamine-6-phosphate isomerase 3374817..3375572 Escherichia coli IAI1 7125730 YP_002388627.1 CDS yraH NC_011741.1 3375972 3376556 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein 3375972..3376556 Escherichia coli IAI1 7125731 YP_002388628.1 CDS yraI NC_011741.1 3376636 3377331 D Evidence 2b : Function of strongly homologous gene; PubMedId : 11677609; Product type f : factor; periplasmic pilin chaperone 3376636..3377331 Escherichia coli IAI1 7128073 YP_002388629.1 CDS yraJ NC_011741.1 3377361 3379877 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane protein 3377361..3379877 Escherichia coli IAI1 7128074 YP_002388630.1 CDS yraK NC_011741.1 3379888 3380979 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein 3379888..3380979 Escherichia coli IAI1 7128075 YP_002388631.1 CDS yraL NC_011741.1 3381022 3381882 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase complement(3381022..3381882) Escherichia coli IAI1 7128076 YP_002388632.1 CDS yraM NC_011741.1 3381946 3383982 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3381946..3383982 Escherichia coli IAI1 7128077 YP_002388633.1 CDS yraN NC_011741.1 3383940 3384335 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3383940..3384335 Escherichia coli IAI1 7128078 YP_002388634.1 CDS yraO NC_011741.1 3384355 3384945 D Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; DnaA initiator-associating protein DiaA 3384355..3384945 Escherichia coli IAI1 7128079 YP_002388635.1 CDS ecfH NC_011741.1 3384955 3385530 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3384955..3385530 Escherichia coli IAI1 7128080 YP_002388636.1 CDS yraQ NC_011741.1 3385644 3386684 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease complement(3385644..3386684) Escherichia coli IAI1 7125043 YP_002388637.1 CDS yraR NC_011741.1 3386757 3387392 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleoside-diphosphate-sugar epimerase complement(3386757..3387392) Escherichia coli IAI1 7128081 YP_002388638.1 CDS yhbO NC_011741.1 3387520 3388038 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative intracellular protease 3387520..3388038 Escherichia coli IAI1 7128082 YP_002388639.1 CDS yhbP NC_011741.1 3388018 3388461 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3388018..3388461) Escherichia coli IAI1 7128749 YP_002388640.1 CDS yhbQ NC_011741.1 3388512 3388814 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; GIY-YIG nuclease superfamily protein 3388512..3388814 Escherichia coli IAI1 7128750 YP_002388641.1 CDS yhbS NC_011741.1 3388801 3389304 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyltransferase with acyl-CoA N-acyltransferase domain complement(3388801..3389304) Escherichia coli IAI1 7128751 YP_002388642.1 CDS yhbT NC_011741.1 3389298 3389822 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative lipid carrier protein complement(3389298..3389822) Escherichia coli IAI1 7128752 YP_002388643.1 CDS yhbU NC_011741.1 3390031 3391026 D Evidence 2b : Function of strongly homologous gene; PubMedId : 10206698; Product type e : enzyme; peptidase 3390031..3391026 Escherichia coli IAI1 7128753 YP_002388644.1 CDS yhbV NC_011741.1 3391035 3391913 D Evidence 2b : Function of strongly homologous gene; PubMedId : 10206698; Product type e : enzyme; protease 3391035..3391913 Escherichia coli IAI1 7128754 YP_002388645.1 CDS yhbW NC_011741.1 3392119 3393126 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3392119..3393126 Escherichia coli IAI1 7128755 YP_002388646.1 CDS mtr NC_011741.1 3393244 3394488 R tryptophan transporter of high affinity; tryptophan permease complement(3393244..3394488) Escherichia coli IAI1 7128756 YP_002388647.1 CDS deaD NC_011741.1 3394642 3396531 R participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD complement(3394642..3396531) Escherichia coli IAI1 7124488 YP_002388648.1 CDS nlpI NC_011741.1 3396711 3397595 R lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI complement(3396711..3397595) Escherichia coli IAI1 7124556 YP_002388649.1 CDS pnp NC_011741.1 3397704 3399908 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87083499, 91198209, 99234021, 99340204, 2432069, 3005122, 6382163, 9008164, 9298646; Product type e : enzyme; polynucleotide phosphorylase/polyadenylase complement(3397704..3399908) Escherichia coli IAI1 7127892 YP_002388650.1 CDS rpsO NC_011741.1 3400086 3400355 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(3400086..3400355) Escherichia coli IAI1 7127970 YP_002388651.1 CDS truB NC_011741.1 3400504 3401448 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(3400504..3401448) Escherichia coli IAI1 7128421 YP_002388652.1 CDS rbfA NC_011741.1 3401448 3401849 R associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A complement(3401448..3401849) Escherichia coli IAI1 7127503 YP_002388653.1 CDS infB NC_011741.1 3402013 3404685 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(3402013..3404685) Escherichia coli IAI1 7126590 YP_002388654.1 CDS nusA NC_011741.1 3404710 3406197 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(3404710..3406197) Escherichia coli IAI1 7126065 YP_002388655.1 CDS yhbC NC_011741.1 3406225 3406677 R in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein complement(3406225..3406677) Escherichia coli IAI1 7125973 YP_002388656.1 CDS argG NC_011741.1 3407308 3408651 D catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 3407308..3408651 Escherichia coli IAI1 7128039 YP_002388657.1 CDS yhbX NC_011741.1 3408659 3410284 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase, inner membrane complement(3408659..3410284) Escherichia coli IAI1 7125791 YP_002388658.1 CDS secG NC_011741.1 3410844 3411176 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20194819, 21125563, 9020118, 94074540, 9564033, 9644254, 9829959, 99298179, 7556084, 8034620, 8045257, 8244950, 8253068; Product type t : transporter; preprotein translocase subunit SecG complement(3410844..3411176) Escherichia coli IAI1 7128037 YP_002388659.1 CDS glmM NC_011741.1 3411404 3412741 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(3411404..3412741) Escherichia coli IAI1 7124696 YP_002388660.1 CDS folP NC_011741.1 3412734 3413582 R catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase complement(3412734..3413582) Escherichia coli IAI1 7128318 YP_002388661.1 CDS hflB NC_011741.1 3413672 3415606 R inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease complement(3413672..3415606) Escherichia coli IAI1 7127266 YP_002388662.1 CDS rrmJ NC_011741.1 3415706 3416335 R Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase J complement(3415706..3416335) Escherichia coli IAI1 7128235 YP_002388663.1 CDS yhbY NC_011741.1 3416461 3416754 D RNA binding protein found associated to pre-50S subunit of the ribosome; putative role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 3416461..3416754 Escherichia coli IAI1 7128430 YP_002388664.1 CDS greA NC_011741.1 3416910 3417386 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(3416910..3417386) Escherichia coli IAI1 7128758 YP_002388665.1 CDS dacB NC_011741.1 3417634 3419067 D penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase/endopeptidase 3417634..3419067 Escherichia coli IAI1 7128463 YP_002388666.1 CDS obgE NC_011741.1 3419107 3420279 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(3419107..3420279) Escherichia coli IAI1 7126909 YP_002388667.1 CDS yhbE NC_011741.1 3420295 3421260 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3420295..3421260) Escherichia coli IAI1 7125976 YP_002388668.1 CDS rpmA NC_011741.1 3421387 3421644 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(3421387..3421644) Escherichia coli IAI1 7128746 YP_002388669.1 CDS rplU NC_011741.1 3421665 3421976 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91088242, 94146411, 10094780, 387076, 8312607; Product type s : structure; 50S ribosomal protein L21 complement(3421665..3421976) Escherichia coli IAI1 7128387 YP_002388670.1 CDS ispB NC_011741.1 3422235 3423206 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94311902, 97284515, 2670911, 8037730, 8312607; Product type e : enzyme; octaprenyl diphosphate synthase 3422235..3423206 Escherichia coli IAI1 7128382 YP_002388671.1 CDS sfsB NC_011741.1 3423434 3423712 D activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 3423434..3423712 Escherichia coli IAI1 7126080 YP_002388672.1 CDS murA NC_011741.1 3423760 3425019 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(3423760..3425019) Escherichia coli IAI1 7127922 YP_002388673.1 CDS yrbA NC_011741.1 3425074 3425328 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3425074..3425328) Escherichia coli IAI1 7124492 YP_002388674.1 CDS yrbB NC_011741.1 3425488 3425781 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3425488..3425781) Escherichia coli IAI1 7128083 YP_002388675.1 CDS yrbC NC_011741.1 3425781 3426416 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene ABC transporter membrane protein complement(3425781..3426416) Escherichia coli IAI1 7128084 YP_002388676.1 CDS yrbD NC_011741.1 3426435 3426986 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene ABC transporter membrane protein complement(3426435..3426986) Escherichia coli IAI1 7128085 YP_002388677.1 CDS yrbE NC_011741.1 3426991 3427773 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene ABC transporter membrane protein complement(3426991..3427773) Escherichia coli IAI1 7128086 YP_002388678.1 CDS yrbF NC_011741.1 3427781 3428590 R ATP-binding subunit of a putative ABC toluene efflux transporter; putative ABC transporter ATP-binding protein YrbF complement(3427781..3428590) Escherichia coli IAI1 7128087 YP_002388679.1 CDS yrbG NC_011741.1 3428800 3429777 D YrbG; inner membrane protein involved in cell envelope integrity; putative sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; putative calcium/sodium:proton antiporter 3428800..3429777 Escherichia coli IAI1 7128088 YP_002388680.1 CDS kdsD NC_011741.1 3429791 3430777 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12805358; Product type e : enzyme; D-arabinose 5-phosphate isomerase 3429791..3430777 Escherichia coli IAI1 7128089 YP_002388681.1 CDS kdsC NC_011741.1 3430798 3431364 D forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 3430798..3431364 Escherichia coli IAI1 7126381 YP_002388682.1 CDS yrbK NC_011741.1 3431361 3431936 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3431361..3431936 Escherichia coli IAI1 7126380 YP_002388683.1 CDS lptA NC_011741.1 3431905 3432462 D LptA; periplasmic binding protein part of a putative ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 3431905..3432462 Escherichia coli IAI1 7128090 YP_002388684.1 CDS lptB NC_011741.1 3432469 3433194 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7876255, 9298646, 17056748; Product type pt : putative transporter; putative ABC transporter ATP-binding protein YhbG 3432469..3433194 Escherichia coli IAI1 7127620 YP_002388685.1 CDS rpoN NC_011741.1 3433242 3434675 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 3433242..3434675 Escherichia coli IAI1 7127621 YP_002388686.1 CDS yhbH NC_011741.1 3434698 3434985 D YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; putative sigma(54) modulation protein 3434698..3434985 Escherichia coli IAI1 7128402 YP_002388687.1 CDS ptsN NC_011741.1 3435103 3435594 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88212176, 90136533, 90274974, 95020584, 95181483, 7876255, 8025669, 8444818, 9636714; Product type t : transporter; PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN 3435103..3435594 Escherichia coli IAI1 7128747 YP_002388688.1 CDS yhbJ NC_011741.1 3435640 3436494 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3435640..3436494 Escherichia coli IAI1 7126542 YP_002388689.1 CDS npr NC_011741.1 3436491 3436763 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10473571, 95181483, 7876255, 8025669; Product type t : transporter; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 3436491..3436763 Escherichia coli IAI1 7128748 YP_002388690.1 CDS yrbL NC_011741.1 3436977 3437609 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 89083480; hypothetical protein 3436977..3437609 Escherichia coli IAI1 7127899 YP_002388691.1 CDS mtgA NC_011741.1 3437606 3438334 R glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase complement(3437606..3438334) Escherichia coli IAI1 7128091 YP_002388692.1 CDS elbB NC_011741.1 3438331 3438984 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92246944, 98269038, 1575737, 9603997; Product type pe : putative enzyme; isoprenoid biosynthesis protein complement(3438331..3438984) Escherichia coli IAI1 7124484 YP_002388693.1 CDS arcB NC_011741.1 3439214 3441550 R sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB complement(3439214..3441550) Escherichia coli IAI1 7124663 YP_002388694.1 CDS yhcC NC_011741.1 3441646 3442575 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Fe-S oxidoreductase complement(3441646..3442575) Escherichia coli IAI1 7125785 YP_002388695.1 CDS gltB NC_011741.1 3443157 3447710 D catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase subunit alpha 3443157..3447710 Escherichia coli IAI1 7128760 YP_002388696.1 CDS gltD NC_011741.1 3447723 3449141 D glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 3447723..3449141 Escherichia coli IAI1 7128347 YP_002388697.1 CDS yhcG NC_011741.1 3449325 3450452 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3449325..3450452 Escherichia coli IAI1 7128348 YP_002388698.1 CDS yhcH NC_011741.1 3450512 3450976 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3450512..3450976) Escherichia coli IAI1 7128761 YP_002388699.1 CDS nanK NC_011741.1 3450988 3451887 R catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase complement(3450988..3451887) Escherichia coli IAI1 7128762 YP_002388700.1 CDS nanE NC_011741.1 3451845 3452534 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(3451845..3452534) Escherichia coli IAI1 7124525 YP_002388701.1 CDS nanT NC_011741.1 3452582 3454072 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96011396, 9864311, 7592358; Product type t : transporter; putative sialic acid transporter complement(3452582..3454072) Escherichia coli IAI1 7124524 YP_002388702.1 CDS nanA NC_011741.1 3454181 3455074 R catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase complement(3454181..3455074) Escherichia coli IAI1 7124527 YP_002388703.1 CDS nanR NC_011741.1 3455196 3455987 R Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR complement(3455196..3455987) Escherichia coli IAI1 7124523 YP_002388704.1 CDS dcuD NC_011741.1 3456367 3457734 D YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic; putative cryptic C4-dicarboxylate transporter DcuD 3456367..3457734 Escherichia coli IAI1 7124526 YP_002388705.1 CDS sspB NC_011741.1 3457777 3458274 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12445774, 94293773, 1721886, 3029697, 8022275; Product type f : factor; ClpXP protease specificity-enhancing factor complement(3457777..3458274) Escherichia coli IAI1 7124543 YP_002388706.1 CDS sspA NC_011741.1 3458280 3458918 R transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A complement(3458280..3458918) Escherichia coli IAI1 7127984 YP_002388707.1 CDS rpsI NC_011741.1 3459313 3459705 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(3459313..3459705) Escherichia coli IAI1 7127983 YP_002388708.1 CDS rplM NC_011741.1 3459721 3460149 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(3459721..3460149) Escherichia coli IAI1 7128415 YP_002388709.1 CDS yhcM NC_011741.1 3460368 3461495 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3460368..3461495) Escherichia coli IAI1 7128374 YP_002388710.1 CDS yhcB NC_011741.1 3461689 3462087 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16079137; Product type pe : putative enzyme; cytochrome d ubiquinol oxidase subunit III 3461689..3462087 Escherichia coli IAI1 7128763 YP_002388711.1 CDS degQ NC_011741.1 3462241 3463608 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8830688, 96165272, 8576051, 8576052, 9740056; Product type e : enzyme; serine endoprotease 3462241..3463608 Escherichia coli IAI1 7128759 YP_002388712.1 CDS degS NC_011741.1 3463698 3464765 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15137941, 15225661, 21352996, 96165272, 99431977, 3322223, 8576051; Product type e : enzyme; serine endoprotease 3463698..3464765 Escherichia coli IAI1 7124561 YP_002388713.1 CDS mdh NC_011741.1 3464828 3465766 R oxidizes malate to oxaloacetate; malate dehydrogenase complement(3464828..3465766) Escherichia coli IAI1 7124562 YP_002388714.1 CDS argR NC_011741.1 3466201 3466671 D regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 3466201..3466671 Escherichia coli IAI1 7127680 YP_002388715.1 CDS yhcN NC_011741.1 3467036 3467299 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3467036..3467299 Escherichia coli IAI1 7125797 YP_002388716.1 CDS yhcO NC_011741.1 3467355 3467627 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative barnase inhibitor complement(3467355..3467627) Escherichia coli IAI1 7128764 YP_002388717.1 CDS aaeB NC_011741.1 3467719 3469686 R with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB complement(3467719..3469686) Escherichia coli IAI1 7128765 YP_002388718.1 CDS aaeA NC_011741.1 3469692 3470624 R with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA complement(3469692..3470624) Escherichia coli IAI1 7125676 YP_002388719.1 CDS aaeX NC_011741.1 3470632 3470835 R membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein complement(3470632..3470835) Escherichia coli IAI1 7125675 YP_002388720.1 CDS aaeR NC_011741.1 3471018 3471947 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15489430; Product type r : regulator; putative DNA-binding transcriptional regulator 3471018..3471947 Escherichia coli IAI1 7125678 YP_002388721.1 CDS tldD NC_011741.1 3472075 3473520 R responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD complement(3472075..3473520) Escherichia coli IAI1 7125677 YP_002388722.1 CDS yhdP NC_011741.1 3473676 3477476 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10960106; Product type pm : putative membrane component; hypothetical protein complement(3473676..3477476) Escherichia coli IAI1 7127453 YP_002388723.1 CDS rng NC_011741.1 3477544 3479013 R involved in the processing of the 5'end of 16S rRNA; ribonuclease G complement(3477544..3479013) Escherichia coli IAI1 7128771 YP_002388724.1 CDS yhdE NC_011741.1 3479003 3479596 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(3479003..3479596) Escherichia coli IAI1 7125021 YP_002388725.1 CDS mreD NC_011741.1 3479605 3480093 R part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD complement(3479605..3480093) Escherichia coli IAI1 7128766 YP_002388726.1 CDS ECIAI1_3391 NC_011741.1 3480077 3480208 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3480077..3480208) Escherichia coli IAI1 7124476 YP_002388727.1 CDS mreC NC_011741.1 3480093 3481196 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(3480093..3481196) Escherichia coli IAI1 7125603 YP_002388728.1 CDS mreB NC_011741.1 3481262 3482305 R functions in MreBCD complex in some organisms; rod shape-determining protein MreB complement(3481262..3482305) Escherichia coli IAI1 7124475 YP_002388729.1 CDS ECIAI1_3394 NC_011741.1 3482413 3482601 D Evidence 6 : Doubtful CDS; hypothetical protein 3482413..3482601 Escherichia coli IAI1 7124474 YP_002388730.1 CDS csrD NC_011741.1 3482610 3484550 R regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD complement(3482610..3484550) Escherichia coli IAI1 7125604 YP_002388731.1 CDS yhdH NC_011741.1 3484702 3485676 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 3484702..3485676 Escherichia coli IAI1 7126855 YP_002388732.1 CDS accB NC_011741.1 3486654 3487124 D composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3486654..3487124 Escherichia coli IAI1 7128767 YP_002388733.1 CDS accC NC_011741.1 3487135 3488484 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 3487135..3488484 Escherichia coli IAI1 7125691 YP_002388734.1 CDS yhdT NC_011741.1 3488593 3488835 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3488593..3488835 Escherichia coli IAI1 7125692 YP_002388735.1 CDS panF NC_011741.1 3488825 3490276 D mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 3488825..3490276 Escherichia coli IAI1 7128772 YP_002388736.1 CDS prmA NC_011741.1 3490288 3491169 D methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 3490288..3491169 Escherichia coli IAI1 7124154 YP_002388737.1 CDS dusB NC_011741.1 3491498 3492463 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566, 1459953, 1547773, 2835774, 2837762, 8226664; Product type e : enzyme; tRNA-dihydrouridine synthase B 3491498..3492463 Escherichia coli IAI1 7126153 YP_002388738.1 CDS fis NC_011741.1 3492489 3492785 D Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 3492489..3492785 Escherichia coli IAI1 7125032 YP_002388739.1 CDS yhdJ NC_011741.1 3492871 3493755 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15028690, 9073062; Product type e : enzyme; putative methyltransferase 3492871..3493755 Escherichia coli IAI1 7127120 YP_002388740.1 CDS yhdU NC_011741.1 3493839 3494018 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3493839..3494018 Escherichia coli IAI1 7128768 YP_002388741.1 CDS envR NC_011741.1 3494021 3494683 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8203018, 11257026, 8407802, 1720861; Product type r : regulator; DNA-binding transcriptional regulator EnvR complement(3494021..3494683) Escherichia coli IAI1 7128773 YP_002388742.1 CDS acrE NC_011741.1 3495082 3496239 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012493, 1720861; Product type lp : lipoprotein; cytoplasmic membrane lipoprotein 3495082..3496239 Escherichia coli IAI1 7125075 YP_002388743.1 CDS acrF NC_011741.1 3496251 3499355 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94262163, 99449638, 1720861, 8407802; Product type t : transporter; multidrug efflux system protein 3496251..3499355 Escherichia coli IAI1 7125709 YP_002388744.1 CDS yhdV NC_011741.1 3499608 3499829 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3499608..3499829 Escherichia coli IAI1 7125710 YP_002388745.1 CDS ECIAI1_3411 NC_011741.1 3500055 3500231 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3500055..3500231 Escherichia coli IAI1 7128774 YP_002388746.1 CDS aapJ NC_011741.1 3500368 3501285 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid ABC transporter periplasmic-binding protein 3500368..3501285 Escherichia coli IAI1 7125605 YP_002388747.1 CDS aapQ NC_011741.1 3501353 3502534 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid ABC transporter membrane protein 3501353..3502534 Escherichia coli IAI1 7125679 YP_002388748.1 CDS aapM NC_011741.1 3502544 3503647 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid ABC transporter membrane protein 3502544..3503647 Escherichia coli IAI1 7125682 YP_002388749.1 CDS aapP NC_011741.1 3503655 3504413 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8809753, 8898392; Product type t : transporter; amino-acid ABC transporter ATP-binding protein 3503655..3504413 Escherichia coli IAI1 7125680 YP_002388750.1 CDS yrdA NC_011741.1 3510294 3510848 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3510294..3510848 Escherichia coli IAI1 7126786 YP_002388751.1 CDS yrdB NC_011741.1 3510824 3511081 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3510824..3511081) Escherichia coli IAI1 7128092 YP_002388752.1 CDS aroE NC_011741.1 3511078 3511896 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(3511078..3511896) Escherichia coli IAI1 7128093 YP_002388753.1 CDS yrdC NC_011741.1 3511901 3512473 R RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; putative ribosome maturation factor complement(3511901..3512473) Escherichia coli IAI1 7125806 YP_002388754.1 CDS yrdD NC_011741.1 3512478 3513020 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative DNA topoisomerase complement(3512478..3513020) Escherichia coli IAI1 7128094 YP_002388755.1 CDS smg NC_011741.1 3513049 3513522 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8432722; hypothetical protein complement(3513049..3513522) Escherichia coli IAI1 7128095 YP_002388756.1 CDS smf NC_011741.1 3513494 3514618 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8112305, 8432722; DNA protecting protein DprA complement(3513494..3514618) Escherichia coli IAI1 7127937 YP_002388757.1 CDS def NC_011741.1 3514748 3515257 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 3514748..3515257 Escherichia coli IAI1 7127936 YP_002388758.1 CDS fmt NC_011741.1 3515272 3516219 D modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 3515272..3516219 Escherichia coli IAI1 7124559 YP_002388759.1 CDS rsmB NC_011741.1 3516265 3517554 D catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase B 3516265..3517554 Escherichia coli IAI1 7127254 YP_002388760.1 CDS trkA NC_011741.1 3517576 3518952 D involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 3517576..3518952 Escherichia coli IAI1 7128437 YP_002388761.1 CDS mscL NC_011741.1 3519082 3519492 D forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 3519082..3519492 Escherichia coli IAI1 7127485 YP_002388762.1 CDS yhdL NC_011741.1 3519489 3519707 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3519489..3519707) Escherichia coli IAI1 7124479 YP_002388763.1 CDS zntR NC_011741.1 3519763 3520188 R mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator complement(3519763..3520188) Escherichia coli IAI1 7128769 YP_002388764.1 CDS yhdN NC_011741.1 3520199 3520567 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3520199..3520567) Escherichia coli IAI1 7128127 YP_002388765.1 CDS rplQ NC_011741.1 3520674 3521057 R is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 complement(3520674..3521057) Escherichia coli IAI1 7128770 YP_002388766.1 CDS rpoA NC_011741.1 3521098 3522087 R catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha complement(3521098..3522087) Escherichia coli IAI1 7128378 YP_002388767.1 CDS rpsD NC_011741.1 3522113 3522733 R primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 complement(3522113..3522733) Escherichia coli IAI1 7128396 YP_002388768.1 CDS rpsK NC_011741.1 3522767 3523156 R located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 complement(3522767..3523156) Escherichia coli IAI1 7128410 YP_002388769.1 CDS rpsM NC_011741.1 3523173 3523529 R located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 complement(3523173..3523529) Escherichia coli IAI1 7128417 YP_002388770.1 CDS secY NC_011741.1 3523824 3525155 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(3523824..3525155) Escherichia coli IAI1 7125503 YP_002388771.1 CDS rplO NC_011741.1 3525163 3525597 R late assembly protein; 50S ribosomal protein L15 complement(3525163..3525597) Escherichia coli IAI1 7124698 YP_002388772.1 CDS rpmD NC_011741.1 3525601 3525780 R L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 complement(3525601..3525780) Escherichia coli IAI1 7128376 YP_002388773.1 CDS rpsE NC_011741.1 3525784 3526287 R located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 complement(3525784..3526287) Escherichia coli IAI1 7128390 YP_002388774.1 CDS rplR NC_011741.1 3526302 3526655 R binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 complement(3526302..3526655) Escherichia coli IAI1 7128411 YP_002388775.1 CDS rplF NC_011741.1 3526665 3527198 R ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 complement(3526665..3527198) Escherichia coli IAI1 7128379 YP_002388776.1 CDS rpsH NC_011741.1 3527211 3527603 R binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 complement(3527211..3527603) Escherichia coli IAI1 7128369 YP_002388777.1 CDS rpsN NC_011741.1 3527637 3527942 R located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 complement(3527637..3527942) Escherichia coli IAI1 7128414 YP_002388778.1 CDS rplE NC_011741.1 3527957 3528496 R part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 complement(3527957..3528496) Escherichia coli IAI1 7128420 YP_002388779.1 CDS rplX NC_011741.1 3528511 3528825 R assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 complement(3528511..3528825) Escherichia coli IAI1 7125107 YP_002388780.1 CDS rplN NC_011741.1 3528836 3529207 R binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 complement(3528836..3529207) Escherichia coli IAI1 7128385 YP_002388781.1 CDS rpsQ NC_011741.1 3529372 3529626 R primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 complement(3529372..3529626) Escherichia coli IAI1 7128375 YP_002388782.1 CDS rpmC NC_011741.1 3529626 3529817 R one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 complement(3529626..3529817) Escherichia coli IAI1 7128423 YP_002388783.1 CDS rplP NC_011741.1 3529817 3530227 R located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 complement(3529817..3530227) Escherichia coli IAI1 7128389 YP_002388784.1 CDS rpsC NC_011741.1 3530240 3530941 R forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 complement(3530240..3530941) Escherichia coli IAI1 7128377 YP_002388785.1 CDS rplV NC_011741.1 3530959 3531291 R binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 complement(3530959..3531291) Escherichia coli IAI1 7128409 YP_002388786.1 CDS rpsS NC_011741.1 3531306 3531584 R protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 complement(3531306..3531584) Escherichia coli IAI1 7128383 YP_002388787.1 CDS rplB NC_011741.1 3531601 3532422 R one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 complement(3531601..3532422) Escherichia coli IAI1 7128425 YP_002388788.1 CDS rplW NC_011741.1 3532440 3532742 R binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 complement(3532440..3532742) Escherichia coli IAI1 7128619 YP_002388789.1 CDS rplD NC_011741.1 3532739 3533344 R L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 complement(3532739..3533344) Escherichia coli IAI1 7128384 YP_002388790.1 CDS rplC NC_011741.1 3533355 3533984 R binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 complement(3533355..3533984) Escherichia coli IAI1 7128621 YP_002388791.1 CDS rpsJ NC_011741.1 3534017 3534328 R NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 complement(3534017..3534328) Escherichia coli IAI1 7128620 YP_002388792.1 CDS ECIAI1_3471 NC_011741.1 3534457 3534618 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3534457..3534618) Escherichia coli IAI1 7128416 YP_002388793.1 CDS ECIAI1_3472 NC_011741.1 3534707 3535174 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative bifunctional prepilin peptidase HopD: leader peptidase; methyl transferase 3534707..3535174 Escherichia coli IAI1 7125606 YP_002388794.1 CDS bfr NC_011741.1 3535171 3535647 R iron storage protein; bacterioferritin complement(3535171..3535647) Escherichia coli IAI1 7125607 YP_002388795.1 CDS bfd NC_011741.1 3535720 3535914 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8954950, 9889981, 2661540, 8639572; Product type c : carrier; bacterioferritin-associated ferredoxin complement(3535720..3535914) Escherichia coli IAI1 7124399 YP_002388796.1 CDS tufA NC_011741.1 3536097 3537281 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(3536097..3537281) Escherichia coli IAI1 7124398 YP_002388797.1 CDS fusA NC_011741.1 3537352 3539466 R EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G complement(3537352..3539466) Escherichia coli IAI1 7127516 YP_002388798.1 CDS rpsG NC_011741.1 3539563 3540033 R binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 complement(3539563..3540033) Escherichia coli IAI1 7128256 YP_002388799.1 CDS rpsL NC_011741.1 3540130 3540504 R interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 complement(3540130..3540504) Escherichia coli IAI1 7128413 YP_002388800.1 CDS tusB NC_011741.1 3540630 3540917 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB complement(3540630..3540917) Escherichia coli IAI1 7128418 YP_002388801.1 CDS tusC NC_011741.1 3540925 3541284 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC complement(3540925..3541284) Escherichia coli IAI1 7127520 YP_002388802.1 CDS tusD NC_011741.1 3541284 3541670 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD complement(3541284..3541670) Escherichia coli IAI1 7127521 YP_002388803.1 CDS yheO NC_011741.1 3541670 3542392 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3541670..3542392) Escherichia coli IAI1 7127522 YP_002388804.1 CDS fkpA NC_011741.1 3542559 3543371 R rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase complement(3542559..3543371) Escherichia coli IAI1 7128775 YP_002388805.1 CDS slyX NC_011741.1 3543592 3543810 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3543592..3543810 Escherichia coli IAI1 7127207 YP_002388806.1 CDS slyD NC_011741.1 3543859 3544449 R rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase complement(3543859..3544449) Escherichia coli IAI1 7127935 YP_002388807.1 CDS yheV NC_011741.1 3544544 3544744 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3544544..3544744) Escherichia coli IAI1 7127934 YP_002388808.1 CDS kefB NC_011741.1 3544754 3546559 R involved in potassium efflux; glutathione-regulated potassium-efflux system protein KefB complement(3544754..3546559) Escherichia coli IAI1 7128779 YP_002388809.1 CDS kefG NC_011741.1 3546559 3547113 R required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG complement(3546559..3547113) Escherichia coli IAI1 7126386 YP_002388810.1 CDS yheS NC_011741.1 3547241 3549154 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 3547241..3549154 Escherichia coli IAI1 7126389 YP_002388811.1 CDS yheT NC_011741.1 3549154 3550176 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9889164; Product type pe : putative enzyme; putative hydrolase 3549154..3550176 Escherichia coli IAI1 7128776 YP_002388812.1 CDS yheU NC_011741.1 3550170 3550388 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3550170..3550388 Escherichia coli IAI1 7128777 YP_002388813.1 CDS prkB NC_011741.1 3550442 3551311 D Evidence 2b : Function of strongly homologous gene; PubMedId : 2559876; Product type e : enzyme; phosphoribulokinase 3550442..3551311 Escherichia coli IAI1 7128778 YP_002388814.1 CDS yhfA NC_011741.1 3551366 3551770 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3551366..3551770) Escherichia coli IAI1 7126151 YP_002388815.1 CDS ECIAI1_3495 NC_011741.1 3551850 3552065 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3551850..3552065 Escherichia coli IAI1 7125915 YP_002388816.1 CDS crp NC_011741.1 3552072 3552704 D complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 3552072..3552704 Escherichia coli IAI1 7125608 YP_002388817.1 CDS yhfK NC_011741.1 3552743 3554845 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3552743..3554845 Escherichia coli IAI1 7125914 YP_002388818.1 CDS argD NC_011741.1 3554912 3556132 R DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein complement(3554912..3556132) Escherichia coli IAI1 7128782 YP_002388819.1 CDS pabA NC_011741.1 3556218 3556781 R aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II complement(3556218..3556781) Escherichia coli IAI1 7125789 YP_002388820.1 CDS fic NC_011741.1 3556813 3557415 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92021789, 94095125, 2007139, 2403545, 2546924, 7549107; Product type cp : cell process; cell filamentation protein Fic complement(3556813..3557415) Escherichia coli IAI1 7125428 YP_002388821.1 CDS yhfG NC_011741.1 3557405 3557572 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3557405..3557572) Escherichia coli IAI1 7127106 YP_002388822.1 CDS ppiA NC_011741.1 3557677 3558249 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90272647, 91175755, 1606970, 2001362, 2007139, 2190212, 2403545, 2546924, 8130188, 8180197; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase A complement(3557677..3558249) Escherichia coli IAI1 7128781 YP_002388823.1 CDS tsgA NC_011741.1 3558520 3559701 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20509826; Product type pt : putative transporter; hypothetical protein 3558520..3559701 Escherichia coli IAI1 7126132 YP_002388824.1 CDS nirB NC_011741.1 3559963 3562506 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93062014, 2200672, 2445993, 2543955; Product type e : enzyme; nitrite reductase, large subunit 3559963..3562506 Escherichia coli IAI1 7127510 YP_002388825.1 CDS nirD NC_011741.1 3562503 3562829 D involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 3562503..3562829 Escherichia coli IAI1 7127884 YP_002388826.1 CDS nirC NC_011741.1 3562956 3563762 D member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 3562956..3563762 Escherichia coli IAI1 7127886 YP_002388827.1 CDS cysG NC_011741.1 3563781 3565154 D multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 3563781..3565154 Escherichia coli IAI1 7127885 YP_002388828.1 CDS yhfL NC_011741.1 3565401 3565568 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3565401..3565568 Escherichia coli IAI1 7126892 YP_002388829.1 CDS frlA NC_011741.1 3565863 3567200 D inner membrane protein possibly involved in fructoselysine transport; member of the flr operon; putative fructoselysine transporter 3565863..3567200 Escherichia coli IAI1 7127045 YP_002388830.1 CDS frlB NC_011741.1 3567221 3568243 D catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine; fructoselysine-6-P-deglycase 3567221..3568243 Escherichia coli IAI1 7127275 YP_002388831.1 CDS frlC NC_011741.1 3568293 3569123 D YhfOP; YhfP; YhfO; FrlC; catalyzes the interconversion of fructoselysine and psicoselysine; fructoselysine 3-epimerase 3568293..3569123 Escherichia coli IAI1 7127276 YP_002388832.1 CDS frlD NC_011741.1 3569120 3569905 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12147680; Product type e : enzyme; fructoselysine 6-kinase 3569120..3569905 Escherichia coli IAI1 7127277 YP_002388833.1 CDS frlR NC_011741.1 3570005 3570736 D may act as a transcriptional regulator of a putative fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes; DNA-binding transcriptional regulator FrlR 3570005..3570736 Escherichia coli IAI1 7127278 YP_002388834.1 CDS yhfS NC_011741.1 3570888 3571973 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3570888..3571973) Escherichia coli IAI1 7127279 YP_002388835.1 CDS yhfT NC_011741.1 3571985 3573289 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3571985..3573289) Escherichia coli IAI1 7127126 YP_002388836.1 CDS yhfU NC_011741.1 3573301 3573654 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3573301..3573654) Escherichia coli IAI1 7127127 YP_002388837.1 CDS php NC_011741.1 3573665 3574543 R phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE); putative hydrolase complement(3573665..3574543) Escherichia coli IAI1 7127128 YP_002388838.1 CDS yhfW NC_011741.1 3574540 3575766 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative mutase complement(3574540..3575766) Escherichia coli IAI1 7124222 YP_002388839.1 CDS yhfX NC_011741.1 3575766 3576929 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amino acid racemase complement(3575766..3576929) Escherichia coli IAI1 7127129 YP_002388840.1 CDS yhfY NC_011741.1 3577013 3577375 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3577013..3577375) Escherichia coli IAI1 7127130 YP_002388841.1 CDS yhfZ NC_011741.1 3577392 3578297 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3577392..3578297) Escherichia coli IAI1 7127131 YP_002388842.1 CDS trpS NC_011741.1 3578566 3579570 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase complement(3578566..3579570) Escherichia coli IAI1 7127132 YP_002388843.1 CDS gph NC_011741.1 3579563 3580321 R catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase complement(3579563..3580321) Escherichia coli IAI1 7127501 YP_002388844.1 CDS rpe NC_011741.1 3580314 3580991 R catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase complement(3580314..3580991) Escherichia coli IAI1 7128457 YP_002388845.1 CDS dam NC_011741.1 3581009 3581845 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90136529, 92262475, 92272672, 2549371, 6300769, 7603433, 8341592; Product type e : enzyme; DNA adenine methylase complement(3581009..3581845) Escherichia coli IAI1 7128615 YP_002388846.1 CDS damX NC_011741.1 3581952 3583238 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3581952..3583238) Escherichia coli IAI1 7126914 YP_002388847.1 CDS aroB NC_011741.1 3583330 3584418 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(3583330..3584418) Escherichia coli IAI1 7126915 YP_002388848.1 CDS aroK NC_011741.1 3584475 3584996 R type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I complement(3584475..3584996) Escherichia coli IAI1 7125803 YP_002388849.1 CDS hofQ NC_011741.1 3585397 3586635 R outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; outer membrane porin HofQ complement(3585397..3586635) Escherichia coli IAI1 7125810 YP_002388850.1 CDS yrfA NC_011741.1 3586547 3586951 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3586547..3586951) Escherichia coli IAI1 7125289 YP_002388851.1 CDS yrfB NC_011741.1 3586941 3587381 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3586941..3587381) Escherichia coli IAI1 7128096 YP_002388852.1 CDS yrfC NC_011741.1 3587365 3587904 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial assembly protein complement(3587365..3587904) Escherichia coli IAI1 7128097 YP_002388853.1 CDS yrfD NC_011741.1 3587904 3588683 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative pilus assembly protein complement(3587904..3588683) Escherichia coli IAI1 7128098 YP_002388854.1 CDS mrcA NC_011741.1 3588803 3591355 D bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 3588803..3591355 Escherichia coli IAI1 7128099 YP_002388855.1 CDS nudE NC_011741.1 3591520 3592080 R ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE complement(3591520..3592080) Escherichia coli IAI1 7124470 YP_002388856.1 CDS igaA NC_011741.1 3592400 3594535 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11553591; Product type r : regulator; intracellular growth attenuator protein 3592400..3594535 Escherichia coli IAI1 7125954 YP_002388857.1 CDS yrfG NC_011741.1 3594600 3595268 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 3594600..3595268 Escherichia coli IAI1 7126046 YP_002388858.1 CDS hslR NC_011741.1 3595279 3595680 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9867837, 10675343, 10675344; Product type f : factor; ribosome-associated heat shock protein Hsp15 3595279..3595680 Escherichia coli IAI1 7128100 YP_002388859.1 CDS hslO NC_011741.1 3595705 3596583 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 3595705..3596583 Escherichia coli IAI1 7125314 YP_002388860.1 CDS yhgE NC_011741.1 3596646 3598370 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 20223645; Product type pm : putative membrane component; hypothetical protein complement(3596646..3598370) Escherichia coli IAI1 7125313 YP_002388861.1 CDS ECIAI1_3542 NC_011741.1 3598376 3598522 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3598376..3598522) Escherichia coli IAI1 7127134 YP_002388862.1 CDS ECIAI1_3543 NC_011741.1 3598446 3598577 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3598446..3598577) Escherichia coli IAI1 7125609 YP_002388863.1 CDS pck NC_011741.1 3598749 3600371 D PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 3598749..3600371 Escherichia coli IAI1 7125610 YP_002388864.1 CDS ECIAI1_3545 NC_011741.1 3600488 3600805 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3600488..3600805 Escherichia coli IAI1 7124159 YP_002388865.1 CDS ECIAI1_3546 NC_011741.1 3600864 3601160 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2404279; Product type pr : putative regulator; putative HTH-type transcriptional regulator yiaG 3600864..3601160 Escherichia coli IAI1 7125611 YP_002388866.1 CDS envZ NC_011741.1 3601192 3602544 R membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein complement(3601192..3602544) Escherichia coli IAI1 7125612 YP_002388867.1 CDS ompR NC_011741.1 3602541 3603260 R part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator complement(3602541..3603260) Escherichia coli IAI1 7125077 YP_002388868.1 CDS greB NC_011741.1 3603488 3603964 D necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 3603488..3603964 Escherichia coli IAI1 7125984 YP_002388869.1 CDS yhgF NC_011741.1 3604061 3606382 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8755871; Product type f : factor; transcriptional accessory protein 3604061..3606382 Escherichia coli IAI1 7128464 YP_002388870.1 CDS feoA NC_011741.1 3606839 3607066 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012482, 8407793; Product type t : transporter; ferrous iron transport protein A 3606839..3607066 Escherichia coli IAI1 7127135 YP_002388871.1 CDS feoB NC_011741.1 3607083 3609404 D cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 3607083..3609404 Escherichia coli IAI1 7127085 YP_002388872.1 CDS yhgG NC_011741.1 3609404 3609640 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3609404..3609640 Escherichia coli IAI1 7127086 YP_002388873.1 CDS yhgA NC_011741.1 3609843 3610721 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2678009; Product type ph : phenotype; hypothetical protein 3609843..3610721 Escherichia coli IAI1 7127136 YP_002388874.1 CDS bioH NC_011741.1 3610750 3611520 R Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH complement(3610750..3611520) Escherichia coli IAI1 7127133 YP_002388875.1 CDS gntX NC_011741.1 3611558 3612241 D involved in high-affinity gluconate transport; gluconate periplasmic binding protein 3611558..3612241 Escherichia coli IAI1 7124412 YP_002388876.1 CDS gntY NC_011741.1 3612300 3612875 D cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; putative DNA uptake protein 3612300..3612875 Escherichia coli IAI1 7128454 YP_002388877.1 CDS gntT NC_011741.1 3613236 3614552 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 4574689, 4582156, 93139975, 97141270, 98019089, 2845225, 3040894, 7984428, 9045817; Product type t : transporter; gluconate transporter, high-affinity GNT I system 3613236..3614552 Escherichia coli IAI1 7128455 YP_002388878.1 CDS malQ NC_011741.1 3614597 3616681 R amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase complement(3614597..3616681) Escherichia coli IAI1 7128452 YP_002388879.1 CDS malP NC_011741.1 3616691 3619084 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89033892, 10220320, 10469642, 2845225, 3037809, 3155826, 6283313, 6339728, 6986282, 9009262; Product type e : enzyme; maltodextrin phosphorylase complement(3616691..3619084) Escherichia coli IAI1 7127661 YP_002388880.1 CDS malT NC_011741.1 3619696 3622401 D Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 3619696..3622401 Escherichia coli IAI1 7127660 YP_002388881.1 CDS rtcA NC_011741.1 3622444 3623460 R catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase complement(3622444..3623460) Escherichia coli IAI1 7127663 YP_002388882.1 CDS rtcB NC_011741.1 3623464 3624690 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9738023; hypothetical protein complement(3623464..3624690) Escherichia coli IAI1 7124628 YP_002388883.1 CDS rtcR NC_011741.1 3624879 3626477 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9738023, 3045764, 7920643, 7984428; Product type r : regulator; sigma 54-dependent transcriptional regulator of rtcBA expression 3624879..3626477 Escherichia coli IAI1 7124629 YP_002388884.1 CDS glpR NC_011741.1 3626459 3627217 R represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR complement(3626459..3627217) Escherichia coli IAI1 7124630 YP_002388885.1 CDS glpG NC_011741.1 3627234 3628064 R protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG complement(3627234..3628064) Escherichia coli IAI1 7128343 YP_002388886.1 CDS glpE NC_011741.1 3628109 3628435 R belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase complement(3628109..3628435) Escherichia coli IAI1 7128340 YP_002388887.1 CDS glpD NC_011741.1 3628625 3630130 D in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 3628625..3630130 Escherichia coli IAI1 7128338 YP_002388888.1 CDS ECIAI1_3570 NC_011741.1 3630184 3630789 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3630184..3630789) Escherichia coli IAI1 7128337 YP_002388889.1 CDS ECIAI1_3571 NC_011741.1 3630792 3631559 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3630792..3631559) Escherichia coli IAI1 7125613 YP_002388890.1 CDS ECIAI1_3572 NC_011741.1 3631562 3632272 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3631562..3632272) Escherichia coli IAI1 7125614 YP_002388891.1 CDS ECIAI1_3573 NC_011741.1 3632287 3633804 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3632287..3633804) Escherichia coli IAI1 7125615 YP_002388892.1 CDS glgP NC_011741.1 3633920 3636367 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88330897, 91104907, 91236706, 2645169, 2975249, 3047129, 3097003; Product type e : enzyme; glycogen phosphorylase complement(3633920..3636367) Escherichia coli IAI1 7125616 YP_002388893.1 CDS glgA NC_011741.1 3636386 3637819 R catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase complement(3636386..3637819) Escherichia coli IAI1 7128314 YP_002388894.1 CDS glgC NC_011741.1 3637819 3639114 R catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase complement(3637819..3639114) Escherichia coli IAI1 7128311 YP_002388895.1 CDS glgX NC_011741.1 3639132 3641105 R catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching enzyme complement(3639132..3641105) Escherichia coli IAI1 7128313 YP_002388896.1 CDS glgB NC_011741.1 3641102 3643288 R catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme complement(3641102..3643288) Escherichia coli IAI1 7128316 YP_002388897.1 CDS asd NC_011741.1 3643561 3644664 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(3643561..3644664) Escherichia coli IAI1 7128312 YP_002388898.1 CDS yhgN NC_011741.1 3644856 3645449 D YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); putative dITP- and XTP- hydrolase 3644856..3645449 Escherichia coli IAI1 7125828 YP_002388899.1 CDS gntU NC_011741.1 3645506 3646846 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8655507, 9119199, 9135111, 97141270; Product type t : transporter; low affinity gluconate transporter complement(3645506..3646846) Escherichia coli IAI1 7127137 YP_002388900.1 CDS gntK NC_011741.1 3646850 3647377 R thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase 1 complement(3646850..3647377) Escherichia coli IAI1 7128453 YP_002388901.1 CDS gntR NC_011741.1 3647516 3648511 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 9135111, 93139975, 9537375, 8655507; Product type r : regulator; DNA-binding transcriptional repressor complement(3647516..3648511) Escherichia coli IAI1 7128449 YP_002388902.1 CDS yhhW NC_011741.1 3648735 3649430 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3648735..3649430) Escherichia coli IAI1 7128451 YP_002388903.1 CDS yhhX NC_011741.1 3649553 3650590 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10493123; Product type pe : putative enzyme; putative dehydrogenase complement(3649553..3650590) Escherichia coli IAI1 7127155 YP_002388904.1 CDS yhhY NC_011741.1 3650922 3651410 D YhhY; regulated by the fur regulator; unknown function; putative acetyltransferase YhhY 3650922..3651410 Escherichia coli IAI1 7124664 YP_002388905.1 CDS yhhZ NC_011741.1 3651647 3652825 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3651647..3652825 Escherichia coli IAI1 7127157 YP_002388906.1 CDS yrhA NC_011741.1 3652822 3653316 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3652822..3653316 Escherichia coli IAI1 7127158 YP_002388907.1 CDS yrhD NC_011741.1 3653402 3653566 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3653402..3653566 Escherichia coli IAI1 7128101 YP_002388908.1 CDS yrhB NC_011741.1 3653766 3654050 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3653766..3654050 Escherichia coli IAI1 7128103 YP_002388909.1 CDS ggt NC_011741.1 3654088 3655830 R periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase complement(3654088..3655830) Escherichia coli IAI1 7128102 YP_002388910.1 CDS yhhA NC_011741.1 3655950 3656390 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3655950..3656390 Escherichia coli IAI1 7128301 YP_002388911.1 CDS ugpQ NC_011741.1 3656377 3657120 R hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; cytoplasmic glycerophosphodiester phosphodiesterase complement(3656377..3657120) Escherichia coli IAI1 7127138 YP_002388912.1 CDS ugpC NC_011741.1 3657117 3658187 R part of the UgpABCE glycerol-3-phosphate uptake system; glycerol-3-phosphate transporter ATP-binding subunit complement(3657117..3658187) Escherichia coli IAI1 7125526 YP_002388913.1 CDS ugpE NC_011741.1 3658189 3659034 R with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein complement(3658189..3659034) Escherichia coli IAI1 7125524 YP_002388914.1 CDS ugpA NC_011741.1 3659031 3659918 R with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease complement(3659031..3659918) Escherichia coli IAI1 7125525 YP_002388915.1 CDS ugpB NC_011741.1 3660016 3661332 R with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein complement(3660016..3661332) Escherichia coli IAI1 7125522 YP_002388916.1 CDS livF NC_011741.1 3661728 3662441 R with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit complement(3661728..3662441) Escherichia coli IAI1 7125523 YP_002388917.1 CDS livG NC_011741.1 3662443 3663210 R Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit complement(3662443..3663210) Escherichia coli IAI1 7126423 YP_002388918.1 CDS livM NC_011741.1 3663207 3664484 R Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease subunit complement(3663207..3664484) Escherichia coli IAI1 7126424 YP_002388919.1 CDS livH NC_011741.1 3664481 3665407 R LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid transporter permease subunit LivH complement(3664481..3665407) Escherichia coli IAI1 7126428 YP_002388920.1 CDS livK NC_011741.1 3665455 3666564 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702302, 90307651, 2195019, 2649683, 3891753, 4077929, 9298646, 9298646; Product type t : transporter; leucine ABC transporter periplasmic-binding protein complement(3665455..3666564) Escherichia coli IAI1 7126425 YP_002388921.1 CDS yhhK NC_011741.1 3666988 3667371 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3666988..3667371 Escherichia coli IAI1 7126427 YP_002388922.1 CDS ECIAI1_3604 NC_011741.1 3667368 3667895 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3667368..3667895) Escherichia coli IAI1 7127149 YP_002388923.1 CDS ECIAI1_3605 NC_011741.1 3667902 3668168 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3667902..3668168) Escherichia coli IAI1 7125617 YP_002388924.1 CDS livJ NC_011741.1 3668318 3669421 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702302, 90307651, 2195019, 2649682, 328304, 3891753, 4077929, 9298646, 10972807; Product type t : transporter; leucine/isoleucine/valine ABC transporter periplasmic-binding protein complement(3668318..3669421) Escherichia coli IAI1 7125618 YP_002388925.1 CDS rpoH NC_011741.1 3669692 3670546 R binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 complement(3669692..3670546) Escherichia coli IAI1 7126426 YP_002388926.1 CDS ftsX NC_011741.1 3670791 3671849 R putative ABC transporter, membrane protein; cell division protein FtsX complement(3670791..3671849) Escherichia coli IAI1 7128401 YP_002388927.1 CDS ftsE NC_011741.1 3671842 3672510 R putative ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE complement(3671842..3672510) Escherichia coli IAI1 7128242 YP_002388928.1 CDS ftsY NC_011741.1 3672513 3674006 R signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY complement(3672513..3674006) Escherichia coli IAI1 7128234 YP_002388929.1 CDS rsmD NC_011741.1 3674156 3674752 D catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 3674156..3674752 Escherichia coli IAI1 7128243 YP_002388930.1 CDS ECIAI1_3613 NC_011741.1 3674619 3675011 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3674619..3675011 Escherichia coli IAI1 7127139 YP_002388931.1 CDS yhhM NC_011741.1 3675014 3675373 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3675014..3675373) Escherichia coli IAI1 7125619 YP_002388932.1 CDS yhhN NC_011741.1 3675514 3676140 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3675514..3676140 Escherichia coli IAI1 7127150 YP_002388933.1 CDS zntA NC_011741.1 3676214 3678412 D P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 3676214..3678412 Escherichia coli IAI1 7127151 YP_002388934.1 CDS tusA NC_011741.1 3678514 3678759 R TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA complement(3678514..3678759) Escherichia coli IAI1 7128126 YP_002388935.1 CDS yhhQ NC_011741.1 3678980 3679645 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3678980..3679645 Escherichia coli IAI1 7127519 YP_002388936.1 CDS dcrB NC_011741.1 3679718 3680275 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12558182, 8752353; Product type t : transporter; hypothetical protein 3679718..3680275 Escherichia coli IAI1 7127152 YP_002388937.1 CDS yhhS NC_011741.1 3680279 3681496 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; major facilitator superfamily transporter complement(3680279..3681496) Escherichia coli IAI1 7126925 YP_002388938.1 CDS yhhT NC_011741.1 3681628 3682677 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3681628..3682677 Escherichia coli IAI1 7127153 YP_002388939.1 CDS acpT NC_011741.1 3682732 3683319 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20092861, 10625633, 8939709; Product type e : enzyme; holo-(acyl carrier protein) synthase 2 3682732..3683319 Escherichia coli IAI1 7127154 YP_002388940.1 CDS nikA NC_011741.1 3683430 3685004 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12960164, 7934931, 92077434, 7867647; Product type t : transporter; nickel ABC transporter periplasmic-binding protein 3683430..3685004 Escherichia coli IAI1 7125705 YP_002388941.1 CDS nikB NC_011741.1 3685004 3685948 D with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 3685004..3685948 Escherichia coli IAI1 7127877 YP_002388942.1 CDS nikC NC_011741.1 3685945 3686778 D with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 3685945..3686778 Escherichia coli IAI1 7127878 YP_002388943.1 CDS nikD NC_011741.1 3686778 3687542 D with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 3686778..3687542 Escherichia coli IAI1 7127879 YP_002388944.1 CDS nikE NC_011741.1 3687539 3688345 D with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 3687539..3688345 Escherichia coli IAI1 7127880 YP_002388945.1 CDS nikR NC_011741.1 3688351 3688752 D Inhibits transcription at high concentrations of nickel; nickel responsive regulator 3688351..3688752 Escherichia coli IAI1 7127881 YP_002388946.1 CDS ECIAI1_3629 NC_011741.1 3688872 3689231 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3688872..3689231) Escherichia coli IAI1 7127882 YP_002388947.1 CDS yhhJ NC_011741.1 3689562 3690686 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter membrane protein complement(3689562..3690686) Escherichia coli IAI1 7125620 YP_002388948.1 CDS rbbA NC_011741.1 3690686 3693421 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20074572; Product type e : enzyme; ribosome-associated ATPase complement(3690686..3693421) Escherichia coli IAI1 7127148 YP_002388949.1 CDS yhiI NC_011741.1 3693418 3694485 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative HlyD family secretion protein complement(3693418..3694485) Escherichia coli IAI1 7126589 YP_002388950.1 CDS yhiJ NC_011741.1 3694851 3696473 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3694851..3696473) Escherichia coli IAI1 7127161 YP_002388951.1 CDS ECIAI1_3634 NC_011741.1 3696735 3698324 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3696735..3698324) Escherichia coli IAI1 7127162 YP_002388952.1 CDS yhiM NC_011741.1 3698708 3699760 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3698708..3699760 Escherichia coli IAI1 7125621 YP_002388953.1 CDS yhiN NC_011741.1 3700076 3701278 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(3700076..3701278) Escherichia coli IAI1 7127163 YP_002388954.1 CDS pitA NC_011741.1 3701510 3703009 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87014120; Product type t : transporter; phosphate transporter, low-affinity 3701510..3703009 Escherichia coli IAI1 7127164 YP_002388955.1 CDS yhiO NC_011741.1 3703080 3703415 R ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB complement(3703080..3703415) Escherichia coli IAI1 7124226 YP_002388956.1 CDS uspA NC_011741.1 3703806 3704240 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 93086426, 93308072, 94203056, 10499297, 10652104, 10931298, 11157932, 1453957, 8506346, 8932299, 9298646, 9405142; Product type f : factor; universal stress global response regulator 3703806..3704240 Escherichia coli IAI1 7127165 YP_002388957.1 CDS yhiP NC_011741.1 3704558 3706027 D member of the POT family of peptide transporters; probable proton-dependent peptide transporter function; inner membrane transporter YhiP 3704558..3706027 Escherichia coli IAI1 7125550 YP_002388958.1 CDS yhiQ NC_011741.1 3706076 3706828 R predicted SAM-dependent methyltransferase; putative methyltransferase complement(3706076..3706828) Escherichia coli IAI1 7127166 YP_002388959.1 CDS prlC NC_011741.1 3706836 3708878 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92394891, 1325967, 8366062; Product type e : enzyme; oligopeptidase A complement(3706836..3708878) Escherichia coli IAI1 7127167 YP_002388960.1 CDS yhiR NC_011741.1 3709081 3709923 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11591672; Product type pe : putative enzyme; putative DNA (exogenous) processing protein 3709081..3709923 Escherichia coli IAI1 7126152 YP_002388961.1 CDS gor NC_011741.1 3709995 3711347 D catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 3709995..3711347 Escherichia coli IAI1 7127168 YP_002388962.1 CDS ECIAI1_3646 NC_011741.1 3711506 3711685 D Evidence 6 : Doubtful CDS; hypothetical protein 3711506..3711685 Escherichia coli IAI1 7128456 YP_002388963.1 CDS arsR NC_011741.1 3712224 3712577 D regulates the expression of of the arsRBC involved in resistance to arsenic; DNA-binding transcriptional repressor ArsR 3712224..3712577 Escherichia coli IAI1 7125622 YP_002388964.1 CDS arsB NC_011741.1 3712631 3713920 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15004242, 95355341, 1535622, 7721697; Product type t : transporter; arsenite/antimonite transporter 3712631..3713920 Escherichia coli IAI1 7125819 YP_002388965.1 CDS arsC NC_011741.1 3713933 3714358 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95355341, 7721697; Product type e : enzyme; arsenate reductase 3713933..3714358 Escherichia coli IAI1 7125817 YP_002388966.1 CDS ECIAI1_3651 NC_011741.1 3714492 3714851 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3714492..3714851) Escherichia coli IAI1 7125818 YP_002388967.1 CDS ECIAI1_3652 NC_011741.1 3714883 3715896 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 3714883..3715896 Escherichia coli IAI1 7125623 YP_002388968.1 CDS ECIAI1_3653 NC_011741.1 3716476 3717699 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3716476..3717699 Escherichia coli IAI1 7125624 YP_002388969.1 CDS slp NC_011741.1 3717946 3718512 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293775, 8022277; Product type lp : lipoprotein; outer membrane lipoprotein 3717946..3718512 Escherichia coli IAI1 7125625 YP_002388970.1 CDS yhiF NC_011741.1 3718668 3719198 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8022277; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3718668..3719198 Escherichia coli IAI1 7127930 YP_002388971.1 CDS yhiD NC_011741.1 3719240 3719887 R inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli; putative Mg(2+) transport ATPase complement(3719240..3719887) Escherichia coli IAI1 7127160 YP_002388972.1 CDS hdeB NC_011741.1 3719951 3720277 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94064579, 8885264, 12071744, 8244952, 8455549, 9298646, 9868784; Product type pf : putative factor; acid-resistance protein complement(3719951..3720277) Escherichia coli IAI1 7127159 YP_002388973.1 CDS hdeA NC_011741.1 3720393 3720725 R inactive form; acid-resistance protein complement(3720393..3720725) Escherichia coli IAI1 7128500 YP_002388974.1 CDS hdeD NC_011741.1 3720980 3721552 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94064579, 8244952, 8455549; Product type pm : putative membrane component; acid-resistance membrane protein 3720980..3721552 Escherichia coli IAI1 7128499 YP_002388975.1 CDS gadE NC_011741.1 3722351 3722878 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12399493, 12940989, 14702398; Product type r : regulator; DNA-binding transcriptional activator 3722351..3722878 Escherichia coli IAI1 7128501 YP_002388976.1 CDS mdtE NC_011741.1 3723217 3724374 D with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds; multidrug efflux system protein MdtE 3723217..3724374 Escherichia coli IAI1 7128264 YP_002388977.1 CDS mdtF NC_011741.1 3724399 3727512 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803; Product type t : transporter; multidrug transporter, RpoS-dependent 3724399..3727512 Escherichia coli IAI1 7127692 YP_002388978.1 CDS gadW NC_011741.1 3727875 3728603 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12446650; Product type r : regulator; DNA-binding transcriptional activator complement(3727875..3728603) Escherichia coli IAI1 7127693 YP_002388979.1 CDS gadX NC_011741.1 3728971 3729795 R regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX complement(3728971..3729795) Escherichia coli IAI1 7128267 YP_002388980.1 CDS gadA NC_011741.1 3730165 3731565 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92155241, 92394884, 99406302, 1522060, 1740158, 7764225, 9298646; Product type e : enzyme; glutamate decarboxylase A, PLP-dependent complement(3730165..3731565) Escherichia coli IAI1 7128266 YP_002388981.1 CDS yhjA NC_011741.1 3731776 3733173 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8163487, 14563563; Product type e : enzyme; cytochrome C peroxidase (cpp-like) complement(3731776..3733173) Escherichia coli IAI1 7128261 YP_002388982.1 CDS treF NC_011741.1 3733578 3735227 D cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 3733578..3735227 Escherichia coli IAI1 7127169 YP_002388983.1 CDS yhjB NC_011741.1 3735278 3735880 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding response regulator in two-component regulatory system complement(3735278..3735880) Escherichia coli IAI1 7127482 YP_002388984.1 CDS yhjC NC_011741.1 3736328 3737299 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3736328..3737299 Escherichia coli IAI1 7127170 YP_002388985.1 CDS yhjD NC_011741.1 3737348 3738361 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3737348..3738361 Escherichia coli IAI1 7127171 YP_002388986.1 CDS yhjE NC_011741.1 3738772 3740094 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3738772..3740094 Escherichia coli IAI1 7127172 YP_002388987.1 CDS yhjG NC_011741.1 3740328 3742403 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane biogenesis protein complement(3740328..3742403) Escherichia coli IAI1 7127173 YP_002388988.1 CDS yhjH NC_011741.1 3742458 3743225 R in Escherichia coli this protein is involved in flagellar function; EAL domain-containing protein complement(3742458..3743225) Escherichia coli IAI1 7127174 YP_002388989.1 CDS ECIAI1_3676 NC_011741.1 3743179 3743373 D Evidence 6 : Doubtful CDS; hypothetical protein 3743179..3743373 Escherichia coli IAI1 7127175 YP_002388990.1 CDS kdgK NC_011741.1 3743457 3744386 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4359651, 13813474; Product type e : enzyme; ketodeoxygluconokinase 3743457..3744386 Escherichia coli IAI1 7125626 YP_002388991.1 CDS yhjJ NC_011741.1 3744482 3745978 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pe : putative enzyme; putative zinc-dependent peptidase complement(3744482..3745978) Escherichia coli IAI1 7126370 YP_002388992.1 CDS dctA NC_011741.1 3746199 3747485 R involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA complement(3746199..3747485) Escherichia coli IAI1 7127176 YP_002388993.1 CDS yhjK NC_011741.1 3747668 3749617 R HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a putative phosphodiesterase protein from E. coli; putative phosphodiesterase complement(3747668..3749617) Escherichia coli IAI1 7126926 YP_002388994.1 CDS bcsC NC_011741.1 3749738 3753211 R cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA; cellulose synthase subunit BcsC complement(3749738..3753211) Escherichia coli IAI1 7127177 YP_002388995.1 CDS bcsZ NC_011741.1 3753193 3754299 R catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase complement(3753193..3754299) Escherichia coli IAI1 7124388 YP_002388996.1 CDS bcsB NC_011741.1 3754306 3756645 R binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein complement(3754306..3756645) Escherichia coli IAI1 7124392 YP_002388997.1 CDS bcsA NC_011741.1 3756656 3759274 R polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis; cellulose synthase catalytic subunit complement(3756656..3759274) Escherichia coli IAI1 7124387 YP_002388998.1 CDS ECIAI1_3685 NC_011741.1 3759271 3760023 R cell division protein complement(3759271..3760023) Escherichia coli IAI1 7124386 YP_002388999.1 CDS yhjR NC_011741.1 3760035 3760223 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3760035..3760223) Escherichia coli IAI1 7125627 YP_002389000.1 CDS bcsE NC_011741.1 3760496 3762067 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929533, 11260463; Product type pe : putative enzyme; putative cellulose biosynthesis protease 3760496..3762067 Escherichia coli IAI1 7127178 YP_002389001.1 CDS bcsF NC_011741.1 3762064 3762255 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3762064..3762255 Escherichia coli IAI1 7124389 YP_002389002.1 CDS bcsG NC_011741.1 3762252 3763931 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929533, 11260463; Product type pe : putative enzyme; putative cellulose biosynthesis endoglucanase 3762252..3763931 Escherichia coli IAI1 7124390 YP_002389003.1 CDS ldrD NC_011741.1 3764501 3764776 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123448; Product type f : factor; toxic polypeptide, small complement(3764501..3764776) Escherichia coli IAI1 7126605 YP_002389004.1 CDS ldrD NC_011741.1 3764984 3765226 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123448; Product type f : factor; toxic polypeptide, small complement(3764984..3765226) Escherichia coli IAI1 7126402 YP_002389005.1 CDS ECIAI1_3696 NC_011741.1 3765739 3765900 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3765739..3765900) Escherichia coli IAI1 7126606 YP_002389006.1 CDS yhjV NC_011741.1 3766050 3767321 D Evidence 2b : Function of strongly homologous gene; PubMedId : 15901718; Product type t : transporter; transporter 3766050..3767321 Escherichia coli IAI1 7125628 YP_002389007.1 CDS dppF NC_011741.1 3767351 3768355 R Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit complement(3767351..3768355) Escherichia coli IAI1 7127179 YP_002389008.1 CDS dppD NC_011741.1 3768352 3769335 R DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit complement(3768352..3769335) Escherichia coli IAI1 7124620 YP_002389009.1 CDS dppC NC_011741.1 3769346 3770248 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7536291; Product type t : transporter; dipeptide transporter complement(3769346..3770248) Escherichia coli IAI1 7124619 YP_002389010.1 CDS dppB NC_011741.1 3770258 3771277 R transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB complement(3770258..3771277) Escherichia coli IAI1 7124618 YP_002389011.1 CDS ECIAI1_3702 NC_011741.1 3771295 3771438 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3771295..3771438 Escherichia coli IAI1 7124617 YP_002389012.1 CDS dppA NC_011741.1 3771428 3773035 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100289, 92065799, 1702779, 1956284, 7536291, 8527431, 8563629, 9298646, 9600841, 9740056, 10972807; Product type t : transporter; dipeptide ABC transporter periplasmic-binding protein complement(3771428..3773035) Escherichia coli IAI1 7125629 YP_002389013.1 CDS ECIAI1_3704 NC_011741.1 3773741 3774073 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3773741..3774073 Escherichia coli IAI1 7124616 YP_002389014.1 CDS eptB NC_011741.1 3774116 3775807 R catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase complement(3774116..3775807) Escherichia coli IAI1 7128033 YP_002389015.1 CDS lpfE NC_011741.1 3776060 3776584 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type pm : putative membrane component; LpfE protein complement(3776060..3776584) Escherichia coli IAI1 7125087 YP_002389016.1 CDS lpfD NC_011741.1 3776590 3777645 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; LpfD protein complement(3776590..3777645) Escherichia coli IAI1 7127617 YP_002389017.1 CDS lpfC NC_011741.1 3777656 3780187 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; outer membrane usher protein lpfC complement(3777656..3780187) Escherichia coli IAI1 7127615 YP_002389018.1 CDS lpfB NC_011741.1 3780211 3780897 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; Chaperone protein lpfB complement(3780211..3780897) Escherichia coli IAI1 7126444 YP_002389019.1 CDS lpfA NC_011741.1 3780981 3781505 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; Long polar fimbria protein A complement(3780981..3781505) Escherichia coli IAI1 7126443 YP_002389020.1 CDS yhjX NC_011741.1 3781830 3783077 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(3781830..3783077) Escherichia coli IAI1 7126441 YP_002389021.1 CDS yhjY NC_011741.1 3783261 3783959 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3783261..3783959) Escherichia coli IAI1 7127180 YP_002389022.1 CDS tag NC_011741.1 3784117 3784680 D constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyl-adenine DNA glycosylase I 3784117..3784680 Escherichia coli IAI1 7127181 YP_002389023.1 CDS yiaC NC_011741.1 3784677 3785117 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11237876; Product type pe : putative enzyme; hypothetical protein 3784677..3785117 Escherichia coli IAI1 7126207 YP_002389024.1 CDS bisC NC_011741.1 3785086 3787365 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82119950, 90202748, 2180922, 374979; Product type e : enzyme; biotin sulfoxide reductase complement(3785086..3787365) Escherichia coli IAI1 7127184 YP_002389025.1 CDS yiaD NC_011741.1 3787572 3788231 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein 3787572..3788231 Escherichia coli IAI1 7124415 YP_002389026.1 CDS tiaE NC_011741.1 3788335 3789309 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15801772, 11237876, 99030322, 99357626, 9298646, 9811658; Product type e : enzyme; 2-oxo-carboxylic acid reductase 3788335..3789309 Escherichia coli IAI1 7127185 YP_002389027.1 CDS yiaF NC_011741.1 3789359 3790069 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3789359..3790069) Escherichia coli IAI1 7126258 YP_002389028.1 CDS yiaG NC_011741.1 3790503 3790793 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3790503..3790793 Escherichia coli IAI1 7127186 YP_002389029.1 CDS ECIAI1_3721 NC_011741.1 3791011 3791433 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3791011..3791433) Escherichia coli IAI1 7127187 YP_002389030.1 CDS cspA NC_011741.1 3791074 3791286 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20345064, 90115858, 94293754, 94293756, 99177178, 10696873, 1597410, 1961761, 2404279, 7515185, 8197194, 9405743, 9439003, 9692981; Product type f : factor; major cold shock protein 3791074..3791286 Escherichia coli IAI1 7125631 YP_002389031.1 CDS glyS NC_011741.1 3791952 3794021 R glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(3791952..3794021) Escherichia coli IAI1 7125931 YP_002389032.1 CDS glyQ NC_011741.1 3794031 3794942 R glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(3794031..3794942) Escherichia coli IAI1 7128360 YP_002389033.1 CDS ysaB NC_011741.1 3795037 3795336 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3795037..3795336) Escherichia coli IAI1 7128359 YP_002389034.1 CDS yiaH NC_011741.1 3795511 3796506 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3795511..3796506 Escherichia coli IAI1 7128104 YP_002389035.1 CDS yiaA NC_011741.1 3796548 3796985 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3796548..3796985) Escherichia coli IAI1 7127188 YP_002389036.1 CDS yiaB NC_011741.1 3797031 3797372 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6320721; Product type pm : putative membrane component; hypothetical protein complement(3797031..3797372) Escherichia coli IAI1 7127182 YP_002389037.1 CDS xylB NC_011741.1 3797541 3798995 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6330500, 92366447, 95050816, 6320721; Product type e : enzyme; xylulokinase complement(3797541..3798995) Escherichia coli IAI1 7127183 YP_002389038.1 CDS xylA NC_011741.1 3799067 3800389 R catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase complement(3799067..3800389) Escherichia coli IAI1 7126478 YP_002389039.1 CDS xylF NC_011741.1 3800755 3801747 D periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 3800755..3801747 Escherichia coli IAI1 7126477 YP_002389040.1 CDS xylG NC_011741.1 3801825 3803366 D with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit 3801825..3803366 Escherichia coli IAI1 7126480 YP_002389041.1 CDS xylH NC_011741.1 3803344 3804525 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94316500; Product type t : transporter; D-xylose ABC transporter membrane protein 3803344..3804525 Escherichia coli IAI1 7126481 YP_002389042.1 CDS ECIAI1_3734 NC_011741.1 3804437 3804613 D Evidence 6 : Doubtful CDS; hypothetical protein 3804437..3804613 Escherichia coli IAI1 7126482 YP_002389043.1 CDS xylR NC_011741.1 3804603 3805781 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6330500, 94316500; Product type r : regulator; DNA-binding transcriptional activator, xylose-binding 3804603..3805781 Escherichia coli IAI1 7125632 YP_002389044.1 CDS bax NC_011741.1 3805889 3806713 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1544897; hypothetical protein complement(3805889..3806713) Escherichia coli IAI1 7126483 YP_002389045.1 CDS malS NC_011741.1 3807033 3809063 D periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase 3807033..3809063 Escherichia coli IAI1 7124383 YP_002389046.1 CDS avtA NC_011741.1 3809241 3810494 D transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 3809241..3810494 Escherichia coli IAI1 7127662 YP_002389047.1 CDS yiaI NC_011741.1 3810646 3811119 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative hydrogenase, 4Fe-4S ferredoxin-type component complement(3810646..3811119) Escherichia coli IAI1 7126283 YP_002389048.1 CDS yiaJ NC_011741.1 3811221 3812069 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 20372646, 9826648; Product type r : regulator; DNA-binding transcriptional repressor complement(3811221..3812069) Escherichia coli IAI1 7127189 YP_002389049.1 CDS yiaK NC_011741.1 3812270 3813268 D NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; 2,3-diketo-L-gulonate reductase 3812270..3813268 Escherichia coli IAI1 7127190 YP_002389050.1 CDS yiaL NC_011741.1 3813280 3813747 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21617392; hypothetical protein 3813280..3813747 Escherichia coli IAI1 7127191 YP_002389051.1 CDS yiaM NC_011741.1 3813865 3814338 D membrane-spanning protein involved in uptake of 2,3-diketo-L-gulonate; part of the tri-partite ATP-independent periplasmic transport system (TRAP) YiaMNO; 2,3-diketo-L-gulonate TRAP transporter small permease YiaM 3813865..3814338 Escherichia coli IAI1 7127192 YP_002389052.1 CDS yiaN NC_011741.1 3814341 3815618 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14668138, 21617392; Product type t : transporter; transporter 3814341..3815618 Escherichia coli IAI1 7127193 YP_002389053.1 CDS yiaO NC_011741.1 3815631 3816617 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14668138, 21617392; Product type t : transporter; transporter 3815631..3816617 Escherichia coli IAI1 7127194 YP_002389054.1 CDS lyxK NC_011741.1 3816621 3818117 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21617392, 95050816, 7961955; Product type e : enzyme; L-xylulose kinase 3816621..3818117 Escherichia coli IAI1 7127195 YP_002389055.1 CDS sgbH NC_011741.1 3818114 3818776 D catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate; 3-keto-L-gulonate-6-phosphate decarboxylase 3818114..3818776 Escherichia coli IAI1 7127648 YP_002389056.1 CDS sgbU NC_011741.1 3818769 3819629 D L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; putative L-xylulose 5-phosphate 3-epimerase 3818769..3819629 Escherichia coli IAI1 7127924 YP_002389057.1 CDS sgbE NC_011741.1 3819623 3820318 D catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 3819623..3820318 Escherichia coli IAI1 7127925 YP_002389058.1 CDS yiaT NC_011741.1 3820665 3821405 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3820665..3821405) Escherichia coli IAI1 7127923 YP_002389059.1 CDS yiaU NC_011741.1 3821529 3822503 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3821529..3822503 Escherichia coli IAI1 7127196 YP_002389060.1 CDS yiaV NC_011741.1 3822500 3823636 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15668009; Product type t : transporter; membrane fusion protein (MFP) component of efflux pump complement(3822500..3823636) Escherichia coli IAI1 7127197 YP_002389061.1 CDS yiaW NC_011741.1 3823642 3823965 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3823642..3823965) Escherichia coli IAI1 7127198 YP_002389062.1 CDS ECIAI1_3755 NC_011741.1 3824079 3824291 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3824079..3824291 Escherichia coli IAI1 7127199 YP_002389063.1 CDS aldB NC_011741.1 3824510 3826048 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95286498, 7768815; Product type e : enzyme; aldehyde dehydrogenase B complement(3824510..3826048) Escherichia coli IAI1 7125633 YP_002389064.1 CDS yiaY NC_011741.1 3826213 3827364 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2935393; Product type e : enzyme; putative alcohol dehydrogenase complement(3826213..3827364) Escherichia coli IAI1 7125742 YP_002389065.1 CDS selB NC_011741.1 3827554 3829398 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264431, 91317715, 9315303, 94148228, 2140572, 2531290; Product type f : factor; selenocysteinyl-tRNA-specific translation factor complement(3827554..3829398) Escherichia coli IAI1 7127200 YP_002389066.1 CDS selA NC_011741.1 3829395 3830786 R catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase complement(3829395..3830786) Escherichia coli IAI1 7124700 YP_002389067.1 CDS yibF NC_011741.1 3830884 3831492 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8387990; Product type pe : putative enzyme; putative glutathione S-transferase complement(3830884..3831492) Escherichia coli IAI1 7124699 YP_002389068.1 CDS ECIAI1_3761 NC_011741.1 3831491 3831634 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3831491..3831634 Escherichia coli IAI1 7127202 YP_002389069.1 CDS yibG NC_011741.1 3835961 3836422 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3835961..3836422 Escherichia coli IAI1 7125635 YP_002389070.1 CDS ECIAI1_3765 NC_011741.1 3836604 3836762 D Ankyrin repeat domain-containing protein 52 (fragment) 3836604..3836762 Escherichia coli IAI1 7127203 YP_002389071.1 CDS ECIAI1_3766 NC_011741.1 3837129 3837566 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3837129..3837566 Escherichia coli IAI1 7125636 YP_002389072.1 CDS yibH NC_011741.1 3838026 3839162 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3838026..3839162) Escherichia coli IAI1 7125637 YP_002389073.1 CDS yibI NC_011741.1 3839165 3839527 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3839165..3839527) Escherichia coli IAI1 7127204 YP_002389074.1 CDS mtlA NC_011741.1 3840064 3841977 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92052139, 92283796, 94131964, 1946374, 3135464, 3142516, 6309813, 9551558; Product type t : transporter; PTS system mannitol-specific transporter subunit IIABC 3840064..3841977 Escherichia coli IAI1 7127205 YP_002389075.1 CDS mtlD NC_011741.1 3842207 3843355 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90254197, 1964486, 3135464, 6384188, 8300537, 13295236; Product type e : enzyme; mannitol-1-phosphate 5-dehydrogenase 3842207..3843355 Escherichia coli IAI1 7124485 YP_002389076.1 CDS mtlR NC_011741.1 3843355 3843942 D Acts as a repressor of the mtlAD operon; mannitol repressor protein 3843355..3843942 Escherichia coli IAI1 7124486 YP_002389077.1 CDS yibT NC_011741.1 3843954 3844163 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3843954..3844163) Escherichia coli IAI1 7124487 YP_002389078.1 CDS yibL NC_011741.1 3844448 3844810 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3844448..3844810 Escherichia coli IAI1 7128141 YP_002389079.1 CDS ECIAI1_3774 NC_011741.1 3845353 3846036 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3845353..3846036 Escherichia coli IAI1 7128138 YP_002389080.1 CDS ECIAI1_3775 NC_011741.1 3846080 3850930 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3846080..3850930 Escherichia coli IAI1 7125638 YP_002389081.1 CDS lldP NC_011741.1 3851299 3852954 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012541, 11283302, 11785976, 8407843; Product type t : transporter; L-lactate permease 3851299..3852954 Escherichia coli IAI1 7125639 YP_002389082.1 CDS lldR NC_011741.1 3852954 3853730 D represses the lctPRD operon; DNA-binding transcriptional repressor LldR 3852954..3853730 Escherichia coli IAI1 7126430 YP_002389083.1 CDS lldD NC_011741.1 3853727 3854917 D flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 3853727..3854917 Escherichia coli IAI1 7126431 YP_002389084.1 CDS yibK NC_011741.1 3855103 3855576 D member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; putative tRNA/rRNA methyltransferase YibK 3855103..3855576 Escherichia coli IAI1 7126429 YP_002389085.1 CDS cysE NC_011741.1 3855629 3856450 R catalyzes the O-acetylation of serine; serine acetyltransferase complement(3855629..3856450) Escherichia coli IAI1 7124461 YP_002389086.1 CDS gpsA NC_011741.1 3856530 3857549 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(3856530..3857549) Escherichia coli IAI1 7126891 YP_002389087.1 CDS secB NC_011741.1 3857549 3858016 R molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB complement(3857549..3858016) Escherichia coli IAI1 7128461 YP_002389088.1 CDS grxC NC_011741.1 3858079 3858330 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94316500, 95024051, 99175138, 11031118, 7937896, 8636094, 9973569; Product type c : carrier; glutaredoxin 3 complement(3858079..3858330) Escherichia coli IAI1 7124692 YP_002389089.1 CDS yibN NC_011741.1 3858472 3858903 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative rhodanese-related sulfurtransferase complement(3858472..3858903) Escherichia coli IAI1 7128470 YP_002389090.1 CDS gpmI NC_011741.1 3859148 3860692 D catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 3859148..3860692 Escherichia coli IAI1 7128139 YP_002389091.1 CDS envC NC_011741.1 3860726 3861985 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12113939, 21972773; Product type cp : cell process; hypothetical protein 3860726..3861985 Escherichia coli IAI1 7128459 YP_002389092.1 CDS yibQ NC_011741.1 3861989 3862948 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative polysaccharide deacetylase 3861989..3862948 Escherichia coli IAI1 7125074 YP_002389093.1 CDS yibD NC_011741.1 3862935 3863969 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15659689, 2647748; Product type pe : putative enzyme; putative glycosyl transferase complement(3862935..3863969) Escherichia coli IAI1 7128140 YP_002389094.1 CDS tdh NC_011741.1 3864208 3865233 R converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase complement(3864208..3865233) Escherichia coli IAI1 7127201 YP_002389095.1 CDS kbl NC_011741.1 3865243 3866439 R catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase complement(3865243..3866439) Escherichia coli IAI1 7126232 YP_002389096.1 CDS rfaD NC_011741.1 3866653 3867585 D catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-mannoheptose-6-epimerase 3866653..3867585 Escherichia coli IAI1 7126096 YP_002389097.1 CDS waaF NC_011741.1 3867595 3868641 D catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose:LPS heptosyltransferase II 3867595..3868641 Escherichia coli IAI1 7125575 YP_002389098.1 CDS waaC NC_011741.1 3868645 3869616 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20507564, 92250420, 93239678, 9446588, 1624462, 8478319; Product type e : enzyme; ADP-heptose:LPS heptosyl transferase I 3868645..3869616 Escherichia coli IAI1 7125576 YP_002389099.1 CDS waaL NC_011741.1 3869686 3870939 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92250420, 92325067, 93054344, 1624462; Product type e : enzyme; lipid A-core surface O-antigen ligase complement(3869686..3870939) Escherichia coli IAI1 7125574 YP_002389100.1 CDS waaV NC_011741.1 3870985 3871968 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative beta1,3-glucosyltransferase complement(3870985..3871968) Escherichia coli IAI1 7125578 YP_002389101.1 CDS waaW NC_011741.1 3872053 3873078 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9791168, 9756860, 9792656; Product type e : enzyme; UDP-galactose:(Galactosyl) LPS alpha1, 2-galactosyltransferase complement(3872053..3873078) Escherichia coli IAI1 7125583 YP_002389102.1 CDS waaY NC_011741.1 3873104 3873796 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92250420, 92325067, 9756860; Product type e : enzyme; lipopolysaccharide core biosynthesis protein complement(3873104..3873796) Escherichia coli IAI1 7125584 YP_002389103.1 CDS waaT NC_011741.1 3873806 3874801 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9791168, 9756860, 9792656; Product type e : enzyme; UDP-galactose:(glucosyl) LPS alpha1, 2-galactosyltransferase complement(3873806..3874801) Escherichia coli IAI1 7125585 YP_002389104.1 CDS waaO NC_011741.1 3874818 3875834 R Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme; UDP-glucose:(glucosyl) LPS alpha1, 3-glucosyltransferase complement(3874818..3875834) Escherichia coli IAI1 7125582 YP_002389105.1 CDS waaP NC_011741.1 3875850 3876656 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101922, 92121133, 92210496, 9756860, 1732225; Product type e : enzyme; kinase that phosphorylates core heptose of lipopolysaccharide complement(3875850..3876656) Escherichia coli IAI1 7125579 YP_002389106.1 CDS waaG NC_011741.1 3876640 3877764 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92121133, 92210496, 92250420, 1447141, 1732225, 7988890; Product type e : enzyme; glucosyltransferase I complement(3876640..3877764) Escherichia coli IAI1 7125580 YP_002389107.1 CDS waaQ NC_011741.1 3877761 3878819 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9756860, 1447141, 1732225; Product type e : enzyme; lipopolysaccharide core biosynthesis protein complement(3877761..3878819) Escherichia coli IAI1 7125577 YP_002389108.1 CDS kdtA NC_011741.1 3879223 3880500 D catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 3879223..3880500 Escherichia coli IAI1 7125581 YP_002389109.1 CDS coaD NC_011741.1 3880508 3880987 D Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 3880508..3880987 Escherichia coli IAI1 7126382 YP_002389110.1 CDS mutM NC_011741.1 3881026 3881835 R Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase complement(3881026..3881835) Escherichia coli IAI1 7126343 YP_002389111.1 CDS rpmG NC_011741.1 3881933 3882100 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 complement(3881933..3882100) Escherichia coli IAI1 7124504 YP_002389112.1 CDS rpmB NC_011741.1 3882121 3882357 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(3882121..3882357) Escherichia coli IAI1 7128393 YP_002389113.1 CDS ECIAI1_3808 NC_011741.1 3882447 3882569 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3882447..3882569 Escherichia coli IAI1 7128388 YP_002389114.1 CDS radC NC_011741.1 3882574 3883242 R Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC complement(3882574..3883242) Escherichia coli IAI1 7125640 YP_002389115.1 CDS dfp NC_011741.1 3883414 3884634 D catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 3883414..3884634 Escherichia coli IAI1 7128152 YP_002389116.1 CDS dut NC_011741.1 3884615 3885070 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 3884615..3885070 Escherichia coli IAI1 7124570 YP_002389117.1 CDS slmA NC_011741.1 3885177 3885773 D FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 3885177..3885773 Escherichia coli IAI1 7125034 YP_002389118.1 CDS pyrE NC_011741.1 3885810 3886451 R involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase complement(3885810..3886451) Escherichia coli IAI1 7127515 YP_002389119.1 CDS rph NC_011741.1 3886516 3887256 R RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH complement(3886516..3887256) Escherichia coli IAI1 7126572 YP_002389120.1 CDS yicC NC_011741.1 3887359 3888222 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3887359..3888222 Escherichia coli IAI1 7128616 YP_002389121.1 CDS dinD NC_011741.1 3888431 3889045 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type cp : cell process; DNA-damage-inducible protein D 3888431..3889045 Escherichia coli IAI1 7128142 YP_002389122.1 CDS yicG NC_011741.1 3889336 3889953 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3889336..3889953 Escherichia coli IAI1 7124587 YP_002389123.1 CDS ligB NC_011741.1 3889950 3891632 R this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB complement(3889950..3891632) Escherichia coli IAI1 7128144 YP_002389124.1 CDS gmk NC_011741.1 3891890 3892513 D Essential for recycling GMP and indirectly, cGMP; guanylate kinase 3891890..3892513 Escherichia coli IAI1 7126419 YP_002389125.1 CDS rpoZ NC_011741.1 3892568 3892843 D promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 3892568..3892843 Escherichia coli IAI1 7128363 YP_002389126.1 CDS spoT NC_011741.1 3892862 3894970 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12224635, 89255395, 93266525, 94068533, 2005134, 2549050; Product type e : enzyme; bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 3892862..3894970 Escherichia coli IAI1 7128405 YP_002389127.1 CDS trmH NC_011741.1 3894977 3895666 D specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 3894977..3895666 Escherichia coli IAI1 7127962 YP_002389128.1 CDS recG NC_011741.1 3895672 3897753 D catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 3895672..3897753 Escherichia coli IAI1 7127492 YP_002389129.1 CDS ECIAI1_3825 NC_011741.1 3897738 3898604 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3897738..3898604) Escherichia coli IAI1 7124950 YP_002389130.1 CDS gltS NC_011741.1 3898607 3899812 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91203811, 93106943, 1544582, 2017136, 2254324; Product type t : transporter; glutamate transporter complement(3898607..3899812) Escherichia coli IAI1 7125641 YP_002389131.1 CDS yicE NC_011741.1 3900092 3901483 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3900092..3901483 Escherichia coli IAI1 7128354 YP_002389132.1 CDS yicH NC_011741.1 3901604 3903313 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3901604..3903313 Escherichia coli IAI1 7128143 YP_002389133.1 CDS yicI NC_011741.1 3903366 3905684 R catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase YicI complement(3903366..3905684) Escherichia coli IAI1 7128145 YP_002389134.1 CDS yicJ NC_011741.1 3905694 3907076 R may be involved in the transport of galactosides-pentoses-hexuronides; putative transporter complement(3905694..3907076) Escherichia coli IAI1 7128146 YP_002389135.1 CDS ECIAI1_3832 NC_011741.1 3907569 3907712 D Evidence 6 : Doubtful CDS; hypothetical protein 3907569..3907712 Escherichia coli IAI1 7128007 YP_002389136.1 CDS setC NC_011741.1 3908100 3909284 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10438463, 10209755; Product type pt : putative transporter; putative sugar efflux system 3908100..3909284 Escherichia coli IAI1 7125642 YP_002389137.1 CDS yicL NC_011741.1 3909395 3910318 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3909395..3910318 Escherichia coli IAI1 7127914 YP_002389138.1 CDS nlpA NC_011741.1 3910322 3911140 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88298691, 89359178, 9914480, 3003106; Product type lp : lipoprotein; cytoplasmic membrane lipoprotein-28 complement(3910322..3911140) Escherichia coli IAI1 7128148 YP_002389139.1 CDS yicS NC_011741.1 3911362 3911655 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3911362..3911655 Escherichia coli IAI1 7127887 YP_002389140.1 CDS nepI NC_011741.1 3911696 3913051 R experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter complement(3911696..3913051) Escherichia coli IAI1 7128153 YP_002389141.1 CDS yicN NC_011741.1 3913097 3913549 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3913097..3913549) Escherichia coli IAI1 7128149 YP_002389142.1 CDS yicO NC_011741.1 3913602 3914936 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative xanthine/uracil permease complement(3913602..3914936) Escherichia coli IAI1 7128150 YP_002389143.1 CDS ade NC_011741.1 3915111 3916877 D catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 3915111..3916877 Escherichia coli IAI1 7128151 YP_002389144.1 CDS uhpT NC_011741.1 3916922 3918313 R cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter complement(3916922..3918313) Escherichia coli IAI1 7125716 YP_002389145.1 CDS uhpC NC_011741.1 3918451 3919770 R membrane protein regulates uhpT expression; regulatory protein UhpC complement(3918451..3919770) Escherichia coli IAI1 7125530 YP_002389146.1 CDS uhpB NC_011741.1 3919780 3921282 R Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB complement(3919780..3921282) Escherichia coli IAI1 7125529 YP_002389147.1 CDS uhpA NC_011741.1 3921282 3921872 R response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; DNA-binding transcriptional activator UhpA complement(3921282..3921872) Escherichia coli IAI1 7125528 YP_002389148.1 CDS ilvN NC_011741.1 3921947 3922237 R with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit complement(3921947..3922237) Escherichia coli IAI1 7125527 YP_002389149.1 CDS ilvB NC_011741.1 3922241 3923929 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2989782, 85242083, 92380929, 2989781; Product type e : enzyme; acetolactate synthase catalytic subunit complement(3922241..3923929) Escherichia coli IAI1 7126060 YP_002389151.1 CDS ivbL NC_011741.1 3924035 3924133 R Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; ilvB operon leader peptide complement(3924035..3924133) Escherichia coli IAI1 7126051 YP_002389152.1 CDS ECIAI1_3849 NC_011741.1 3924407 3924565 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3924407..3924565 Escherichia coli IAI1 7126089 YP_002389153.1 CDS ECIAI1_3850 NC_011741.1 3924662 3924913 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3924662..3924913) Escherichia coli IAI1 7125643 YP_002389154.1 CDS emrD NC_011741.1 3925206 3926390 D multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 3925206..3926390 Escherichia coli IAI1 7125644 YP_002389155.1 CDS yidF NC_011741.1 3926398 3926895 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3926398..3926895) Escherichia coli IAI1 7125062 YP_002389156.1 CDS yidG NC_011741.1 3926892 3927254 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3926892..3927254) Escherichia coli IAI1 7128159 YP_002389157.1 CDS yidH NC_011741.1 3927244 3927591 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3927244..3927591) Escherichia coli IAI1 7128160 YP_002389158.1 CDS yidI NC_011741.1 3927701 3928150 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3927701..3928150 Escherichia coli IAI1 7128161 YP_002389159.1 CDS yidJ NC_011741.1 3928197 3929690 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sulfatase/phosphatase complement(3928197..3929690) Escherichia coli IAI1 7128162 YP_002389160.1 CDS yidK NC_011741.1 3929687 3931402 R uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function; putative symporter YidK complement(3929687..3931402) Escherichia coli IAI1 7128163 YP_002389161.1 CDS yidL NC_011741.1 3931539 3932462 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3931539..3932462 Escherichia coli IAI1 7128164 YP_002389162.1 CDS ECIAI1_3861 NC_011741.1 3933273 3935150 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative PTS system alpha-glucoside-specific EIICB component complement(3933273..3935150) Escherichia coli IAI1 7125646 YP_002389163.1 CDS yidP NC_011741.1 3935185 3935901 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3935185..3935901 Escherichia coli IAI1 7125647 YP_002389164.1 CDS yidE NC_011741.1 3935898 3937559 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1356969; Product type pt : putative transporter; hypothetical protein complement(3935898..3937559) Escherichia coli IAI1 7128166 YP_002389165.1 CDS ibpB NC_011741.1 3937756 3938184 R 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB complement(3937756..3938184) Escherichia coli IAI1 7128158 YP_002389166.1 CDS ibpA NC_011741.1 3938296 3938709 R with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA complement(3938296..3938709) Escherichia coli IAI1 7126040 YP_002389167.1 CDS yidQ NC_011741.1 3939015 3939347 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3939015..3939347 Escherichia coli IAI1 7126039 YP_002389168.1 CDS yidR NC_011741.1 3939349 3940563 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3939349..3940563) Escherichia coli IAI1 7128167 YP_002389169.1 CDS cbrA NC_011741.1 3940664 3941728 D FAD/NAD(P)-binding domain; putative oxidoreductase 3940664..3941728 Escherichia coli IAI1 7128168 YP_002389170.1 CDS dgoT NC_011741.1 3941725 3943017 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type t : transporter; D-galactonate transporter complement(3941725..3943017) Escherichia coli IAI1 7124453 YP_002389171.1 CDS dgoD NC_011741.1 3943137 3944285 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type e : enzyme; galactonate dehydratase complement(3943137..3944285) Escherichia coli IAI1 7124576 YP_002389172.1 CDS dgoA NC_011741.1 3944282 3944899 R catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase complement(3944282..3944899) Escherichia coli IAI1 7124573 YP_002389173.1 CDS dgoK NC_011741.1 3944883 3945761 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type e : enzyme; 2-oxo-3-deoxygalactonate kinase complement(3944883..3945761) Escherichia coli IAI1 7124572 YP_002389174.1 CDS dgoR NC_011741.1 3945758 3946447 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 79020349; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3945758..3946447) Escherichia coli IAI1 7124574 YP_002389175.1 CDS yidX NC_011741.1 3946725 3947381 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 3946725..3947381 Escherichia coli IAI1 7124575 YP_002389176.1 CDS yidA NC_011741.1 3947427 3948239 R YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase complement(3947427..3948239) Escherichia coli IAI1 7128169 YP_002389177.1 CDS yidB NC_011741.1 3948354 3948752 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3948354..3948752) Escherichia coli IAI1 7128154 YP_002389178.1 CDS gyrB NC_011741.1 3948992 3951406 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B complement(3948992..3951406) Escherichia coli IAI1 7128155 YP_002389179.1 CDS recF NC_011741.1 3951435 3952508 R Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F complement(3951435..3952508) Escherichia coli IAI1 7128486 YP_002389180.1 CDS dnaN NC_011741.1 3952508 3953608 R binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta complement(3952508..3953608) Escherichia coli IAI1 7124949 YP_002389181.1 CDS dnaA NC_011741.1 3953613 3955016 R binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein complement(3953613..3955016) Escherichia coli IAI1 7124611 YP_002389182.1 CDS ECIAI1_3881 NC_011741.1 3955530 3955670 R hypothetical protein complement(3955530..3955670) Escherichia coli IAI1 7124604 YP_002389183.1 CDS rpmH NC_011741.1 3955623 3955763 D in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 3955623..3955763 Escherichia coli IAI1 7125648 YP_002389184.1 CDS rnpA NC_011741.1 3955780 3956139 D protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 3955780..3956139 Escherichia coli IAI1 7128394 YP_002389185.1 CDS yidD NC_011741.1 3956103 3956360 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3956103..3956360 Escherichia coli IAI1 7125025 YP_002389186.1 CDS yidC NC_011741.1 3956363 3958009 D functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; putative inner membrane protein translocase component YidC 3956363..3958009 Escherichia coli IAI1 7128157 YP_002389187.1 CDS trmE NC_011741.1 3958115 3959479 D in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 3958115..3959479 Escherichia coli IAI1 7128156 YP_002389188.1 CDS tnaC NC_011741.1 3959722 3959796 D Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; tryptophanase leader peptide 3959722..3959796 Escherichia coli IAI1 7127491 YP_002389189.1 CDS tnaA NC_011741.1 3960017 3961432 D tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 3960017..3961432 Escherichia coli IAI1 7127457 YP_002389190.1 CDS tnaB NC_011741.1 3961523 3962770 D tryptophan transporter of low affinity; tryptophan permease TnaB 3961523..3962770 Escherichia coli IAI1 7127455 YP_002389191.1 CDS mdtL NC_011741.1 3962902 3964077 D Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 3962902..3964077 Escherichia coli IAI1 7127456 YP_002389192.1 CDS yidZ NC_011741.1 3964052 3965011 D Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ 3964052..3965011 Escherichia coli IAI1 7124231 YP_002389193.1 CDS yieE NC_011741.1 3965156 3965917 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphopantetheinyl transferase 3965156..3965917 Escherichia coli IAI1 7128170 YP_002389194.1 CDS yieF NC_011741.1 3965939 3966505 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14766567; Product type e : enzyme; chromate reductase, Class I, flavoprotein 3965939..3966505 Escherichia coli IAI1 7128171 YP_002389195.1 CDS yieG NC_011741.1 3966559 3967896 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3966559..3967896) Escherichia coli IAI1 7128172 YP_002389196.1 CDS yieH NC_011741.1 3968063 3968728 D YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 3968063..3968728 Escherichia coli IAI1 7128173 YP_002389197.1 CDS yieI NC_011741.1 3968795 3969268 D might be involved in hypersensitivity to nitrofurzone; hypothetical protein 3968795..3969268 Escherichia coli IAI1 7128174 YP_002389198.1 CDS cbrC NC_011741.1 3969317 3969904 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3969317..3969904 Escherichia coli IAI1 7128175 YP_002389199.1 CDS yieK NC_011741.1 3969966 3970688 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 6-phosphogluconolactonase complement(3969966..3970688) Escherichia coli IAI1 7124454 YP_002389200.1 CDS yieL NC_011741.1 3970703 3971899 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative xylanase complement(3970703..3971899) Escherichia coli IAI1 7128176 YP_002389201.1 CDS bglH NC_011741.1 3971899 3973515 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10027967; Product type t : transporter; carbohydrate-specific outer membrane porin, cryptic complement(3971899..3973515) Escherichia coli IAI1 7128177 YP_002389202.1 CDS bglB NC_011741.1 3973601 3974995 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 88297127, 92334140, 3034860, 3309161; Product type e : enzyme; cryptic phospho-beta-glucosidase B complement(3973601..3974995) Escherichia coli IAI1 7124404 YP_002389203.1 CDS bglF NC_011741.1 3975014 3976891 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system beta-glucoside-specific transporter subunits IIABC complement(3975014..3976891) Escherichia coli IAI1 7124401 YP_002389204.1 CDS bglG NC_011741.1 3977025 3977861 R positive regulator of the beta-glucoside operon; transcriptional antiterminator; transcriptional antiterminator BglG complement(3977025..3977861) Escherichia coli IAI1 7124402 YP_002389205.1 CDS phoU NC_011741.1 3978147 3978872 R regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU complement(3978147..3978872) Escherichia coli IAI1 7124403 YP_002389206.1 CDS pstB NC_011741.1 3978887 3979660 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(3978887..3979660) Escherichia coli IAI1 7124221 YP_002389207.1 CDS pstA NC_011741.1 3979751 3980641 R Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PtsA complement(3979751..3980641) Escherichia coli IAI1 7126531 YP_002389208.1 CDS pstC NC_011741.1 3980641 3981600 R part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PstC complement(3980641..3981600) Escherichia coli IAI1 7126530 YP_002389209.1 CDS pstS NC_011741.1 3981687 3982727 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90133909, 2215649, 6321434, 6365894, 9228942, 9298646, 9671506; Product type t : transporter; phosphate ABC transporter periplasmic substrate-binding protein PstS complement(3981687..3982727) Escherichia coli IAI1 7126532 YP_002389210.1 CDS lpfD NC_011741.1 3982975 3984048 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12438351, 7721701, 16128397; Product type ps : putative structure; putative fimbrial protein LpfD; putative adhesin complement(3982975..3984048) Escherichia coli IAI1 7126533 YP_002389211.1 CDS lpfC NC_011741.1 3984059 3986581 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7721701, 16128397; Product type pt : putative transporter; putative fimbrial usher complement(3984059..3986581) Escherichia coli IAI1 7127616 YP_002389212.1 CDS lfpB NC_011741.1 3986606 3987337 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16128397, 12438351; Product type pc : putative carrier; putative fimbrial chaperone protein complement(3986606..3987337) Escherichia coli IAI1 7127614 YP_002389213.1 CDS lpfA NC_011741.1 3987385 3987957 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16125910, 12438351; Product type ps : putative structure; putative major fimbrial subunit complement(3987385..3987957) Escherichia coli IAI1 7126415 YP_002389214.1 CDS glmS NC_011741.1 3988259 3990088 R Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase complement(3988259..3990088) Escherichia coli IAI1 7126442 YP_002389215.1 CDS glmU NC_011741.1 3990250 3991620 R forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase complement(3990250..3991620) Escherichia coli IAI1 7128319 YP_002389216.1 CDS atpC NC_011741.1 3991971 3992390 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon complement(3991971..3992390) Escherichia coli IAI1 7128320 YP_002389217.1 CDS atpD NC_011741.1 3992411 3993793 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta complement(3992411..3993793) Escherichia coli IAI1 7126276 YP_002389218.1 CDS atpG NC_011741.1 3993820 3994683 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma complement(3993820..3994683) Escherichia coli IAI1 7126277 YP_002389219.1 CDS atpA NC_011741.1 3994734 3996275 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha complement(3994734..3996275) Escherichia coli IAI1 7126280 YP_002389220.1 CDS atpH NC_011741.1 3996288 3996821 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta complement(3996288..3996821) Escherichia coli IAI1 7126274 YP_002389221.1 CDS atpF NC_011741.1 3996836 3997306 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B complement(3996836..3997306) Escherichia coli IAI1 7126281 YP_002389222.1 CDS atpE NC_011741.1 3997368 3997607 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C complement(3997368..3997607) Escherichia coli IAI1 7126279 YP_002389223.1 CDS atpB NC_011741.1 3997654 3998469 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A complement(3997654..3998469) Escherichia coli IAI1 7126278 YP_002389224.1 CDS atpI NC_011741.1 3998478 3998858 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I complement(3998478..3998858) Escherichia coli IAI1 7126275 YP_002389225.1 CDS gidB NC_011741.1 3999475 4000098 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(3999475..4000098) Escherichia coli IAI1 7126282 YP_002389226.1 CDS gidA NC_011741.1 4000162 4002051 R GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA complement(4000162..4002051) Escherichia coli IAI1 7128303 YP_002389227.1 CDS mioC NC_011741.1 4002430 4002873 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(4002430..4002873) Escherichia coli IAI1 7128302 YP_002389228.1 CDS asnC NC_011741.1 4002963 4003421 R transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC complement(4002963..4003421) Escherichia coli IAI1 7124278 YP_002389229.1 CDS asnA NC_011741.1 4003573 4004565 D catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 4003573..4004565 Escherichia coli IAI1 7126263 YP_002389230.1 CDS yieM NC_011741.1 4004570 4006021 R contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein complement(4004570..4006021) Escherichia coli IAI1 7126261 YP_002389231.1 CDS ravA NC_011741.1 4006015 4007511 R interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA complement(4006015..4007511) Escherichia coli IAI1 7128178 YP_002389232.1 CDS trkD NC_011741.1 4007734 4009602 D Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 4007734..4009602 Escherichia coli IAI1 7126588 YP_002389233.1 CDS rbsD NC_011741.1 4009769 4010188 D cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 4009769..4010188 Escherichia coli IAI1 7127486 YP_002389234.1 CDS rbsA NC_011741.1 4010196 4011701 D with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP binding protein 4010196..4011701 Escherichia coli IAI1 7126595 YP_002389235.1 CDS rbsC NC_011741.1 4011706 4012671 D functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 4011706..4012671 Escherichia coli IAI1 7126592 YP_002389236.1 CDS rbsB NC_011741.1 4012696 4013586 D periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 4012696..4013586 Escherichia coli IAI1 7126594 YP_002389237.1 CDS rbsK NC_011741.1 4013712 4014641 D catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 4013712..4014641 Escherichia coli IAI1 7126593 YP_002389238.1 CDS rbsR NC_011741.1 4014645 4015637 D DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 4014645..4015637 Escherichia coli IAI1 7126596 YP_002389239.1 CDS hsrA NC_011741.1 4015603 4017030 R Evidence 2b : Function of strongly homologous gene; PubMedId : 20218988, 12107133; Product type t : transporter; multidrug or homocysteine efflux system complement(4015603..4017030) Escherichia coli IAI1 7126597 YP_002389240.1 CDS yieP NC_011741.1 4017053 4017745 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator complement(4017053..4017745) Escherichia coli IAI1 7125317 YP_002389241.1 CDS hdfR NC_011741.1 4023544 4024383 R Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR complement(4023544..4024383) Escherichia coli IAI1 7128010 YP_002389242.1 CDS yifE NC_011741.1 4024502 4024840 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4024502..4024840 Escherichia coli IAI1 7128502 YP_002389243.1 CDS yifB NC_011741.1 4024865 4026415 R among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function; putative ATP-dependent protease complement(4024865..4026415) Escherichia coli IAI1 7128181 YP_002389244.1 CDS ilvL NC_011741.1 4026738 4026836 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87174741; Product type l : leader peptide; ilvG operon leader peptide 4026738..4026836 Escherichia coli IAI1 7128180 YP_002389245.1 CDS ilvG NC_011741.1 4026976 4028622 D catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 4026976..4028622 Escherichia coli IAI1 7126058 YP_002389246.1 CDS ilvM NC_011741.1 4028619 4028882 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92332418, 92380929, 1569580, 3550695, 3897211; Product type e : enzyme; acetolactate synthase 2 regulatory subunit 4028619..4028882 Escherichia coli IAI1 7126055 YP_002389247.1 CDS ilvE NC_011741.1 4028902 4029831 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 4028902..4029831 Escherichia coli IAI1 7126059 YP_002389248.1 CDS ilvD NC_011741.1 4029896 4031746 D catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 4029896..4031746 Escherichia coli IAI1 7126054 YP_002389249.1 CDS ilvA NC_011741.1 4031749 4033293 D threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 4031749..4033293 Escherichia coli IAI1 7126053 YP_002389250.1 CDS ilvY NC_011741.1 4033290 4034264 R participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY complement(4033290..4034264) Escherichia coli IAI1 7126050 YP_002389251.1 CDS ilvC NC_011741.1 4034330 4035805 D catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 4034330..4035805 Escherichia coli IAI1 7126061 YP_002389252.1 CDS ppiC NC_011741.1 4035892 4036173 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94215709, 7878732, 7925971, 8163020; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase C complement(4035892..4036173) Escherichia coli IAI1 7126052 YP_002389253.1 CDS ECIAI1_3963 NC_011741.1 4036372 4036863 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4036372..4036863) Escherichia coli IAI1 7126134 YP_002389254.1 CDS rep NC_011741.1 4037038 4039059 D single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 4037038..4039059 Escherichia coli IAI1 7125649 YP_002389255.1 CDS gpp NC_011741.1 4039106 4040590 R catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase complement(4039106..4040590) Escherichia coli IAI1 7124961 YP_002389256.1 CDS rhlB NC_011741.1 4040724 4041989 R enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB complement(4040724..4041989) Escherichia coli IAI1 7128460 YP_002389257.1 CDS trxA NC_011741.1 4042120 4042449 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202710, 91154193, 92250497, 99175138, 10489448, 1094461, 10947986, 1561103, 2181145, 2193685, 3891733, 4616096, 4883076, 6098320, 6099324, 7812718, 8098620, 8253691; Product type c : carrier; thioredoxin 4042120..4042449 Escherichia coli IAI1 7124979 YP_002389258.1 CDS rhoL NC_011741.1 4042590 4042691 D Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; putative rho operon leader peptide 4042590..4042691 Escherichia coli IAI1 7127506 YP_002389259.1 CDS rho NC_011741.1 4042776 4044035 D An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 4042776..4044035 Escherichia coli IAI1 7124982 YP_002389260.1 CDS ECIAI1_3970 NC_011741.1 4044045 4044263 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4044045..4044263 Escherichia coli IAI1 7124981 YP_002389261.1 CDS rfe NC_011741.1 4044275 4045378 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92114763, 94245613, 94292435, 10629198, 11024259, 11700352, 11832520, 1722555, 1730666; Product type e : enzyme; UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase 4044275..4045378 Escherichia coli IAI1 7125650 YP_002389262.1 CDS wzzE NC_011741.1 4045390 4046436 D Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 4045390..4046436 Escherichia coli IAI1 7124964 YP_002389263.1 CDS rffE NC_011741.1 4046492 4047622 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90212314, 90337949, 92112804, 94042873, 11106477, 7559340, 8170390, 8226648; Product type e : enzyme; UDP-N-acetyl glucosamine-2-epimerase 4046492..4047622 Escherichia coli IAI1 7126466 YP_002389264.1 CDS wecC NC_011741.1 4047619 4048881 D catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 4047619..4048881 Escherichia coli IAI1 7124968 YP_002389265.1 CDS rffG NC_011741.1 4048881 4049948 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88086930, 90212314, 90337949, 92112804, 92174908, 94018634, 94042873, 7559340; Product type e : enzyme; dTDP-glucose 4,6-dehydratase 4048881..4049948 Escherichia coli IAI1 7124967 YP_002389266.1 CDS rffH NC_011741.1 4049967 4050848 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94292435, 96032389; Product type e : enzyme; glucose-1-phosphate thymidylyltransferase 4049967..4050848 Escherichia coli IAI1 7124969 YP_002389267.1 CDS rffC NC_011741.1 4050826 4051500 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90212314, 90337949, 92112804, 8366065; Product type e : enzyme; TDP-fucosamine acetyltransferase 4050826..4051500 Escherichia coli IAI1 7124970 YP_002389268.1 CDS rffA NC_011741.1 4051505 4052635 D catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 4051505..4052635 Escherichia coli IAI1 7124966 YP_002389269.1 CDS wzxE NC_011741.1 4052637 4053887 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12621029, 20044778; Product type t : transporter; O-antigen translocase 4052637..4053887 Escherichia coli IAI1 7124965 YP_002389270.1 CDS rffT NC_011741.1 4053884 4054963 D catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 4053884..4054963 Escherichia coli IAI1 7126464 YP_002389271.1 CDS wzyE NC_011741.1 4054960 4056312 D enterobacterial common antigen polymerase; putative common antigen polymerase 4054960..4056312 Escherichia coli IAI1 7124972 YP_002389272.1 CDS rffM NC_011741.1 4056315 4057055 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88086874, 90337949, 92112804; Product type e : enzyme; putative UDP-N-acetyl-D-mannosaminuronic acid transferase 4056315..4057055 Escherichia coli IAI1 7126465 YP_002389273.1 CDS yifK NC_011741.1 4057246 4058631 D uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; putative transport protein YifK 4057246..4058631 Escherichia coli IAI1 7124971 YP_002389274.1 CDS aslB NC_011741.1 4059317 4060552 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11222759, 2180918, 12419807, 14749327; Product type pr : putative regulator; regulator of arylsulfatase activity 4059317..4060552 Escherichia coli IAI1 7128014 YP_002389275.1 CDS hemY NC_011741.1 4061476 4062672 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 89041586; Product type pe : putative enzyme; putative protoheme IX biogenesis protein complement(4061476..4062672) Escherichia coli IAI1 7124665 YP_002389276.1 CDS hemX NC_011741.1 4062675 4063898 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 89098348, 92358234, 3054815, 3062586, 9298646; Product type pe : putative enzyme; putative uroporphyrinogen III C-methyltransferase complement(4062675..4063898) Escherichia coli IAI1 7128516 YP_002389277.1 CDS hemD NC_011741.1 4063920 4064660 R catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase complement(4063920..4064660) Escherichia coli IAI1 7128515 YP_002389278.1 CDS hemC NC_011741.1 4064657 4065598 R transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase complement(4064657..4065598) Escherichia coli IAI1 7128508 YP_002389279.1 CDS cyaA NC_011741.1 4065985 4068531 D catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 4065985..4068531 Escherichia coli IAI1 7128507 YP_002389280.1 CDS cyaY NC_011741.1 4068571 4068891 R defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein complement(4068571..4068891) Escherichia coli IAI1 7126869 YP_002389281.1 CDS ECIAI1_3995 NC_011741.1 4068939 4070252 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4068939..4070252) Escherichia coli IAI1 7126870 YP_002389282.1 CDS ECIAI1_3996 NC_011741.1 4070249 4071757 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4070249..4071757) Escherichia coli IAI1 7125651 YP_002389283.1 CDS ECIAI1_3997 NC_011741.1 4072095 4072649 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4072095..4072649) Escherichia coli IAI1 7125652 YP_002389284.1 CDS ECIAI1_3998 NC_011741.1 4072656 4072790 R Evidence 6 : Doubtful CDS; hypothetical protein complement(4072656..4072790) Escherichia coli IAI1 7125653 YP_002389285.1 CDS yifL NC_011741.1 4072999 4073202 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 4072999..4073202 Escherichia coli IAI1 7125654 YP_002389286.1 CDS dapF NC_011741.1 4073239 4074063 D involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 4073239..4074063 Escherichia coli IAI1 7128183 YP_002389287.1 CDS yigA NC_011741.1 4074060 4074767 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4074060..4074767 Escherichia coli IAI1 7126920 YP_002389288.1 CDS xerC NC_011741.1 4074764 4075660 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 4074764..4075660 Escherichia coli IAI1 7128184 YP_002389289.1 CDS yigB NC_011741.1 4075660 4076376 D YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 4075660..4076376 Escherichia coli IAI1 7126471 YP_002389290.1 CDS uvrD NC_011741.1 4076460 4078622 D unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 4076460..4078622 Escherichia coli IAI1 7128185 YP_002389291.1 CDS yigE NC_011741.1 4078769 4079533 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4078769..4079533) Escherichia coli IAI1 7125558 YP_002389292.1 CDS corA NC_011741.1 4079903 4080853 D responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 4079903..4080853 Escherichia coli IAI1 7128186 YP_002389293.1 CDS ECIAI1_4007 NC_011741.1 4080907 4081386 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4080907..4081386) Escherichia coli IAI1 7126353 YP_002389294.1 CDS ECIAI1_4008 NC_011741.1 4081383 4082237 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4081383..4082237) Escherichia coli IAI1 7125655 YP_002389295.1 CDS ECIAI1_4009 NC_011741.1 4082361 4082564 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4082361..4082564 Escherichia coli IAI1 7125656 YP_002389296.1 CDS ECIAI1_4010 NC_011741.1 4082589 4082867 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4082589..4082867) Escherichia coli IAI1 7125657 YP_002389297.1 CDS ECIAI1_4011 NC_011741.1 4083145 4083489 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4083145..4083489 Escherichia coli IAI1 7125658 YP_002389298.1 CDS rarD NC_011741.1 4083536 4084423 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative chloramphenicol resistance permease complement(4083536..4084423) Escherichia coli IAI1 7125659 YP_002389299.1 CDS yigI NC_011741.1 4084475 4084942 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4084475..4084942) Escherichia coli IAI1 7126587 YP_002389300.1 CDS pldA NC_011741.1 4085107 4085976 D catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 4085107..4085976 Escherichia coli IAI1 7128187 YP_002389301.1 CDS recQ NC_011741.1 4086109 4087938 D functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ 4086109..4087938 Escherichia coli IAI1 7126097 YP_002389302.1 CDS rhtC NC_011741.1 4088002 4088622 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99313167, 10386596, 3027506; Product type t : transporter; threonine efflux system 4088002..4088622 Escherichia coli IAI1 7124954 YP_002389303.1 CDS rhtB NC_011741.1 4088684 4089304 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99313167, 10386596; Product type t : transporter; homoserine/homoserine lactone efflux protein complement(4088684..4089304) Escherichia coli IAI1 7124991 YP_002389304.1 CDS ECIAI1_4019 NC_011741.1 4089303 4089488 D hypothetical protein 4089303..4089488 Escherichia coli IAI1 7124990 YP_002389305.1 CDS pldB NC_011741.1 4089415 4090437 D lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 4089415..4090437 Escherichia coli IAI1 7125660 YP_002389306.1 CDS yigL NC_011741.1 4090445 4091245 D purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; putative sugar phosphatase 4090445..4091245 Escherichia coli IAI1 7126098 YP_002389307.1 CDS yigM NC_011741.1 4091321 4092220 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4091321..4092220 Escherichia coli IAI1 7128188 YP_002389308.1 CDS metR NC_011741.1 4092108 4093061 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90384950, 96303520, 2205852, 2643109; Product type r : regulator; DNA-binding transcriptional activator, homocysteine-binding complement(4092108..4093061) Escherichia coli IAI1 7128189 YP_002389309.1 CDS metE NC_011741.1 4093179 4095440 D catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 4093179..4095440 Escherichia coli IAI1 7124255 YP_002389310.1 CDS ysgA NC_011741.1 4095479 4096294 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12676709; Product type pe : putative enzyme; putative hydrolase complement(4095479..4096294) Escherichia coli IAI1 7124245 YP_002389311.1 CDS udp NC_011741.1 4096556 4097317 D catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 4096556..4097317 Escherichia coli IAI1 7128105 YP_002389312.1 CDS rmuC NC_011741.1 4097458 4098885 D YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 4097458..4098885 Escherichia coli IAI1 7125520 YP_002389313.1 CDS ubiE NC_011741.1 4098980 4099735 D Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 4098980..4099735 Escherichia coli IAI1 7125014 YP_002389314.1 CDS yigP NC_011741.1 4099749 4100354 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4099749..4100354 Escherichia coli IAI1 7125513 YP_002389315.1 CDS ubiB NC_011741.1 4100351 4101991 D an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; putative ubiquinone biosynthesis protein UbiB 4100351..4101991 Escherichia coli IAI1 7128190 YP_002389316.1 CDS tatA NC_011741.1 4102070 4102339 D TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A 4102070..4102339 Escherichia coli IAI1 7125510 YP_002389317.1 CDS tatB NC_011741.1 4102343 4102858 D mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 4102343..4102858 Escherichia coli IAI1 7126214 YP_002389318.1 CDS tatC NC_011741.1 4102861 4103637 D with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 4102861..4103637 Escherichia coli IAI1 7126215 YP_002389319.1 CDS tatD NC_011741.1 4103679 4104461 D magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD 4103679..4104461 Escherichia coli IAI1 7126216 YP_002389320.1 CDS rfaH NC_011741.1 4104458 4104946 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92011415, 92250420, 92261317, 1584020, 12007406; Product type r : regulator; transcriptional activator RfaH complement(4104458..4104946) Escherichia coli IAI1 7126217 YP_002389321.1 CDS ubiD NC_011741.1 4105113 4106606 D catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate decarboxylase 4105113..4106606 Escherichia coli IAI1 7124963 YP_002389322.1 CDS fre NC_011741.1 4106652 4107353 D NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 4106652..4107353 Escherichia coli IAI1 7125512 YP_002389323.1 CDS fadA NC_011741.1 4107545 4108708 R FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase complement(4107545..4108708) Escherichia coli IAI1 7127274 YP_002389324.1 CDS fadB NC_011741.1 4108718 4110907 R includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha complement(4108718..4110907) Escherichia coli IAI1 7127061 YP_002389325.1 CDS pepQ NC_011741.1 4111097 4112428 D catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 4111097..4112428 Escherichia coli IAI1 7127062 YP_002389326.1 CDS yigZ NC_011741.1 4112428 4113042 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15103642; Product type pf : putative factor; hypothetical protein 4112428..4113042 Escherichia coli IAI1 7124175 YP_002389327.1 CDS trkH NC_011741.1 4113081 4114532 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100357, 2243799, 7896723; Product type t : transporter; potassium transporter 4113081..4114532 Escherichia coli IAI1 7128191 YP_002389328.1 CDS hemG NC_011741.1 4114544 4115089 D catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 4114544..4115089 Escherichia coli IAI1 7127487 YP_002389329.1 CDS mobB NC_011741.1 4120671 4121183 R in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; molybdopterin-guanine dinucleotide biosynthesis protein B complement(4120671..4121183) Escherichia coli IAI1 7125485 YP_002389330.1 CDS mobA NC_011741.1 4121180 4121764 R in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA complement(4121180..4121764) Escherichia coli IAI1 7124296 YP_002389331.1 CDS yihD NC_011741.1 4121834 4122103 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4121834..4122103 Escherichia coli IAI1 7124295 YP_002389332.1 CDS yihE NC_011741.1 4122180 4123166 D catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 4122180..4123166 Escherichia coli IAI1 7128193 YP_002389333.1 CDS dsbA NC_011741.1 4123183 4123809 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12498799, 93264419, 94016574, 94206930, 99298180, 10210188, 1429594, 1740115, 1934062, 8413591, 8494885, 8521518, 9194175, 9298646, 9300489, 9572841, 9600841, 9655827; Product type e : enzyme; periplasmic protein disulfide isomerase I 4123183..4123809 Escherichia coli IAI1 7128194 YP_002389334.1 CDS yihF NC_011741.1 4123964 4125394 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4123964..4125394 Escherichia coli IAI1 7124622 YP_002389335.1 CDS yihG NC_011741.1 4125435 4126367 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyltransferase complement(4125435..4126367) Escherichia coli IAI1 7128195 YP_002389336.1 CDS polA NC_011741.1 4126731 4129517 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 4126731..4129517 Escherichia coli IAI1 7128196 YP_002389337.1 CDS ECIAI1_4063 NC_011741.1 4129736 4129885 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4129736..4129885) Escherichia coli IAI1 7127961 YP_002389338.1 CDS engB NC_011741.1 4129899 4130495 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(4129899..4130495) Escherichia coli IAI1 7125661 YP_002389339.1 CDS yihI NC_011741.1 4131113 4131622 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4131113..4131622 Escherichia coli IAI1 7126854 YP_002389340.1 CDS hemN NC_011741.1 4131811 4133184 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4131811..4133184 Escherichia coli IAI1 7128197 YP_002389341.1 CDS glnG NC_011741.1 4133596 4135005 R response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) complement(4133596..4135005) Escherichia coli IAI1 7128514 YP_002389342.1 CDS glnL NC_011741.1 4135017 4136066 R sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) complement(4135017..4136066) Escherichia coli IAI1 7128325 YP_002389343.1 CDS glnA NC_011741.1 4136385 4137794 R forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase complement(4136385..4137794) Escherichia coli IAI1 7128328 YP_002389344.1 CDS ECIAI1_4070 NC_011741.1 4137922 4138074 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4137922..4138074) Escherichia coli IAI1 7128321 YP_002389345.1 CDS bipA NC_011741.1 4138167 4139990 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9642082, 7783627, 9298646, 9622352; Product type f : factor; GTP-binding protein 4138167..4139990 Escherichia coli IAI1 7125662 YP_002389346.1 CDS yihL NC_011741.1 4140207 4140917 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4140207..4140917 Escherichia coli IAI1 7124413 YP_002389347.1 CDS yihM NC_011741.1 4140925 4141905 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar phosphate isomerase 4140925..4141905 Escherichia coli IAI1 7128198 YP_002389348.1 CDS yihN NC_011741.1 4142007 4143272 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4142007..4143272 Escherichia coli IAI1 7128199 YP_002389349.1 CDS ompL NC_011741.1 4143363 4144055 R porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown; outer membrane porin L complement(4143363..4144055) Escherichia coli IAI1 7128200 YP_002389350.1 CDS yihO NC_011741.1 4144123 4145526 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(4144123..4145526) Escherichia coli IAI1 7125982 YP_002389351.1 CDS yihP NC_011741.1 4145569 4146975 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(4145569..4146975) Escherichia coli IAI1 7128201 YP_002389352.1 CDS yihQ NC_011741.1 4147000 4149036 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15294295; Product type e : enzyme; alpha-glucosidase complement(4147000..4149036) Escherichia coli IAI1 7128202 YP_002389353.1 CDS yihR NC_011741.1 4149235 4150161 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldose-1-epimerase complement(4149235..4150161) Escherichia coli IAI1 7128203 YP_002389354.1 CDS yihS NC_011741.1 4150275 4151516 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glucosamine isomerase complement(4150275..4151516) Escherichia coli IAI1 7128204 YP_002389355.1 CDS yihT NC_011741.1 4151533 4152411 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldolase complement(4151533..4152411) Escherichia coli IAI1 7128205 YP_002389356.1 CDS yihU NC_011741.1 4152435 4153331 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(4152435..4153331) Escherichia coli IAI1 7128206 YP_002389357.1 CDS yihV NC_011741.1 4153499 4154395 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar kinase 4153499..4154395 Escherichia coli IAI1 7128207 YP_002389358.1 CDS yihW NC_011741.1 4154429 4155214 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4154429..4155214 Escherichia coli IAI1 7128208 YP_002389359.1 CDS yihX NC_011741.1 4155313 4155912 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; phosphatase 4155313..4155912 Escherichia coli IAI1 7128209 YP_002389360.1 CDS rbn NC_011741.1 4155906 4156778 D RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 4155906..4156778 Escherichia coli IAI1 7128210 YP_002389361.1 CDS dtd NC_011741.1 4156775 4157212 D hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 4156775..4157212 Escherichia coli IAI1 7126591 YP_002389362.1 CDS yiiD NC_011741.1 4157209 4158198 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase 4157209..4158198 Escherichia coli IAI1 7125031 YP_002389363.1 CDS ECIAI1_4089 NC_011741.1 4158262 4159245 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative lipase complement(4158262..4159245) Escherichia coli IAI1 7128211 YP_002389364.1 CDS ECIAI1_4090 NC_011741.1 4159399 4159710 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4159399..4159710 Escherichia coli IAI1 7125663 YP_002389365.1 CDS ECIAI1_4091 NC_011741.1 4159711 4160001 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4159711..4160001 Escherichia coli IAI1 7125664 YP_002389366.1 CDS yiiE NC_011741.1 4160606 4160824 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4160606..4160824 Escherichia coli IAI1 7125665 YP_002389367.1 CDS yiiF NC_011741.1 4161067 4161285 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4161067..4161285 Escherichia coli IAI1 7128212 YP_002389368.1 CDS fdhE NC_011741.1 4161615 4162544 R required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE complement(4161615..4162544) Escherichia coli IAI1 7128213 YP_002389369.1 CDS fdoI NC_011741.1 4162541 4163176 R cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma complement(4162541..4163176) Escherichia coli IAI1 7127073 YP_002389370.1 CDS fdoH NC_011741.1 4163173 4164075 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91317715, 8522521, 9852007; Product type c : carrier; formate dehydrogenase-O, Fe-S subunit complement(4163173..4164075) Escherichia coli IAI1 7127080 YP_002389371.1 CDS fdoG NC_011741.1 4164088 4167138 R Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-O, large subunit complement(4164088..4167138) Escherichia coli IAI1 7127079 YP_002389372.1 CDS fdhD NC_011741.1 4167332 4168165 D involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 4167332..4168165 Escherichia coli IAI1 7127078 YP_002389373.1 CDS yiiG NC_011741.1 4168318 4169358 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4168318..4169358 Escherichia coli IAI1 7127072 YP_002389374.1 CDS frvR NC_011741.1 4169408 4171156 R putative repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system; putative frv operon regulatory protein complement(4169408..4171156) Escherichia coli IAI1 7128214 YP_002389375.1 CDS frvX NC_011741.1 4171156 4172226 R with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars; putative fructose-specific phosphotransferase system protein FrvX complement(4171156..4172226) Escherichia coli IAI1 7128223 YP_002389376.1 CDS frvB NC_011741.1 4172216 4173667 R Evidence 2b : Function of strongly homologous gene; PubMedId : 94290319; Product type t : transporter; putative PTS system transporter subunits IIBC complement(4172216..4173667) Escherichia coli IAI1 7128224 YP_002389377.1 CDS frvA NC_011741.1 4173678 4174124 R with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system; putative fructose-like phosphotransferase system subunit EIIA complement(4173678..4174124) Escherichia coli IAI1 7128222 YP_002389378.1 CDS yiiL NC_011741.1 4174437 4174751 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15060078; Product type e : enzyme; L-rhamnose mutarotase complement(4174437..4174751) Escherichia coli IAI1 7128221 YP_002389379.1 CDS rhaD NC_011741.1 4174761 4175585 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90128204, 93374854, 8396120; Product type e : enzyme; rhamnulose-1-phosphate aldolase complement(4174761..4175585) Escherichia coli IAI1 7128215 YP_002389380.1 CDS rhaA NC_011741.1 4175827 4177086 R catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase complement(4175827..4177086) Escherichia coli IAI1 7124975 YP_002389381.1 CDS rhaB NC_011741.1 4177083 4178552 R catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase complement(4177083..4178552) Escherichia coli IAI1 7124973 YP_002389382.1 CDS rhaS NC_011741.1 4178840 4179676 D activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 4178840..4179676 Escherichia coli IAI1 7124974 YP_002389383.1 CDS rhaR NC_011741.1 4179660 4180598 D activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR 4179660..4180598 Escherichia coli IAI1 7124977 YP_002389384.1 CDS rhaT NC_011741.1 4180595 4181629 R transports L-rhamnose and L-lyxose into the cell; rhamnose-proton symporter complement(4180595..4181629) Escherichia coli IAI1 7124976 YP_002389385.1 CDS sodA NC_011741.1 4181914 4182534 D SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 4181914..4182534 Escherichia coli IAI1 7124978 YP_002389386.1 CDS kdgT NC_011741.1 4182794 4183777 D transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 4182794..4183777 Escherichia coli IAI1 7127941 YP_002389387.1 CDS yiiM NC_011741.1 4183926 4184600 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4183926..4184600 Escherichia coli IAI1 7126372 YP_002389388.1 CDS cpxA NC_011741.1 4184706 4186079 R part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein complement(4184706..4186079) Escherichia coli IAI1 7128216 YP_002389389.1 CDS cpxR NC_011741.1 4186076 4186774 R response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR complement(4186076..4186774) Escherichia coli IAI1 7126360 YP_002389390.1 CDS cpxP NC_011741.1 4186924 4187424 D repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; periplasmic repressor CpxP 4186924..4187424 Escherichia coli IAI1 7126362 YP_002389391.1 CDS fieF NC_011741.1 4187573 4188475 D member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F 4187573..4188475 Escherichia coli IAI1 7126361 YP_002389392.1 CDS pfkA NC_011741.1 4188656 4189618 D catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 4188656..4189618 Escherichia coli IAI1 7127107 YP_002389393.1 CDS sbp NC_011741.1 4189937 4190926 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91161616, 2002055, 3158524, 8774726, 9298646; Product type t : transporter; sulfate transporter subunit 4189937..4190926 Escherichia coli IAI1 7124178 YP_002389394.1 CDS cdh NC_011741.1 4191033 4191788 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86008270, 2995360, 3158524; Product type e : enzyme; CDP-diacylglycerol pyrophosphatase 4191033..4191788 Escherichia coli IAI1 7124680 YP_002389395.1 CDS tpiA NC_011741.1 4191843 4192610 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(4191843..4192610) Escherichia coli IAI1 7126296 YP_002389396.1 CDS yiiQ NC_011741.1 4192718 4193317 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4192718..4193317) Escherichia coli IAI1 7127475 YP_002389397.1 CDS yiiR NC_011741.1 4193418 4193858 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4193418..4193858 Escherichia coli IAI1 7128217 YP_002389398.1 CDS yiiS NC_011741.1 4194070 4194369 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4194070..4194369 Escherichia coli IAI1 7124379 YP_002389399.1 CDS yiiT NC_011741.1 4194396 4194824 D with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 4194396..4194824 Escherichia coli IAI1 7125348 YP_002389400.1 CDS fpr NC_011741.1 4194829 4195575 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93194782, 94092163, 95050480, 95362685, 1400248, 2834327, 7961651, 8449868, 9149148; Product type e : enzyme; ferredoxin-NADP reductase complement(4194829..4195575) Escherichia coli IAI1 7125349 YP_002389401.1 CDS glpX NC_011741.1 4195672 4196682 R type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II complement(4195672..4196682) Escherichia coli IAI1 7127268 YP_002389402.1 CDS glpK NC_011741.1 4196818 4198326 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(4196818..4198326) Escherichia coli IAI1 7128345 YP_002389403.1 CDS glpF NC_011741.1 4198349 4199194 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12629974, 12948772, 14646142, 15004242, 90094250, 92210584, 11039922, 11101882, 11226336, 11964478, 1372899, 2544860, 6998951; Product type t : transporter; glycerol facilitator complement(4198349..4199194) Escherichia coli IAI1 7128341 YP_002389404.1 CDS yiiU NC_011741.1 4199620 4199865 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4199620..4199865 Escherichia coli IAI1 7128339 YP_002389405.1 CDS rraA NC_011741.1 4199950 4200435 R regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA complement(4199950..4200435) Escherichia coli IAI1 7125350 YP_002389406.1 CDS menA NC_011741.1 4200528 4201454 R catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase complement(4200528..4201454) Escherichia coli IAI1 7128428 YP_002389407.1 CDS hslU NC_011741.1 4201521 4202852 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU complement(4201521..4202852) Escherichia coli IAI1 7124235 YP_002389408.1 CDS hslV NC_011741.1 4202862 4203392 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit complement(4202862..4203392) Escherichia coli IAI1 7125315 YP_002389409.1 CDS ftsN NC_011741.1 4203485 4204444 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9282742, 93285993, 8509333; Product type cp : cell process; essential cell division protein FtsN complement(4203485..4204444) Escherichia coli IAI1 7125316 YP_002389410.1 CDS cytR NC_011741.1 4204536 4205561 R negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR complement(4204536..4205561) Escherichia coli IAI1 7128239 YP_002389411.1 CDS priA NC_011741.1 4205717 4207915 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(4205717..4207915) Escherichia coli IAI1 7126905 YP_002389412.1 CDS rpmE NC_011741.1 4208118 4208330 D RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 4208118..4208330 Escherichia coli IAI1 7126148 YP_002389413.1 CDS yiiX NC_011741.1 4213904 4214512 R member of the NlpC/P60 superfamily of peptidases; putative peptidoglycan peptidase complement(4213904..4214512) Escherichia coli IAI1 7126068 YP_002389414.1 CDS metJ NC_011741.1 4214572 4214889 R when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ complement(4214572..4214889) Escherichia coli IAI1 7125351 YP_002389415.1 CDS metB NC_011741.1 4215166 4216326 D catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 4215166..4216326 Escherichia coli IAI1 7124250 YP_002389416.1 CDS metL NC_011741.1 4216329 4218761 D multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 4216329..4218761 Escherichia coli IAI1 7124243 YP_002389417.1 CDS metF NC_011741.1 4219110 4220000 D MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 4219110..4220000 Escherichia coli IAI1 7124252 YP_002389418.1 CDS katG NC_011741.1 4220329 4222509 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90292022, 94209230, 3045098; Product type e : enzyme; catalase/hydroperoxidase HPI(I) 4220329..4222509 Escherichia coli IAI1 7124246 YP_002389419.1 CDS yijE NC_011741.1 4222603 4223508 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease 4222603..4223508 Escherichia coli IAI1 7126093 YP_002389420.1 CDS yijF NC_011741.1 4223535 4224152 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4223535..4224152) Escherichia coli IAI1 7125353 YP_002389421.1 CDS gldA NC_011741.1 4224427 4225530 R forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase complement(4224427..4225530) Escherichia coli IAI1 7125354 YP_002389422.1 CDS fsaB NC_011741.1 4225541 4226203 R similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase complement(4225541..4226203) Escherichia coli IAI1 7128310 YP_002389423.1 CDS ptsA NC_011741.1 4226215 4228716 R Evidence 2b : Function of strongly homologous gene; PubMedId : 95291446, 7773398; Product type t : transporter; putative PTS enzymes Hpr component/ enzyme I component/ enzyme IIA component complement(4226215..4228716) Escherichia coli IAI1 7128229 YP_002389424.1 CDS frwC NC_011741.1 4229025 4230104 D FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site; putative fructose-like permease EIIC subunit 2 4229025..4230104 Escherichia coli IAI1 7126538 YP_002389425.1 CDS frwB NC_011741.1 4230119 4230439 D FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; putative PTS system fructose-like transporter subunit EIIB 4230119..4230439 Escherichia coli IAI1 7128226 YP_002389426.1 CDS pflD NC_011741.1 4230490 4232787 D involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; putative formate acetyltransferase 2 4230490..4232787 Escherichia coli IAI1 7128225 YP_002389427.1 CDS pflC NC_011741.1 4232753 4233631 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95291446, 14673546, 7773398; Product type e : enzyme; pyruvate formate lyase II activase 4232753..4233631 Escherichia coli IAI1 7124183 YP_002389428.1 CDS frwD NC_011741.1 4233633 4233974 D FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; putative fructose-like phosphotransferase EIIB subunit 3 4233633..4233974 Escherichia coli IAI1 7124182 YP_002389429.1 CDS yijO NC_011741.1 4233961 4234812 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(4233961..4234812) Escherichia coli IAI1 7128227 YP_002389430.1 CDS yijP NC_011741.1 4234961 4236694 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10456927; Product type pm : putative membrane component; hypothetical protein complement(4234961..4236694) Escherichia coli IAI1 7125355 YP_002389431.1 CDS ppc NC_011741.1 4236877 4239528 R catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase complement(4236877..4239528) Escherichia coli IAI1 7125356 YP_002389432.1 CDS argE NC_011741.1 4239880 4241031 R catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase complement(4239880..4241031) Escherichia coli IAI1 7126125 YP_002389433.1 CDS argC NC_011741.1 4241185 4242189 D catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 4241185..4242189 Escherichia coli IAI1 7125790 YP_002389434.1 CDS argB NC_011741.1 4242200 4242973 D catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 4242200..4242973 Escherichia coli IAI1 7125788 YP_002389435.1 CDS argH NC_011741.1 4243034 4244407 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 4243034..4244407 Escherichia coli IAI1 7125787 YP_002389436.1 CDS rspA NC_011741.1 4244845 4246119 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 93341455, 94310441; Product type pe : putative enzyme; putative enolase/dehydratase 4244845..4246119 Escherichia coli IAI1 7125792 YP_002389437.1 CDS ECIAI1_4170 NC_011741.1 4246186 4247469 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4246186..4247469 Escherichia coli IAI1 7128440 YP_002389438.1 CDS oxyR NC_011741.1 4247721 4248638 D Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 4247721..4248638 Escherichia coli IAI1 7126003 YP_002389439.1 CDS sthA NC_011741.1 4248621 4250021 R catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase complement(4248621..4250021) Escherichia coli IAI1 7126002 YP_002389440.1 CDS fabR NC_011741.1 4250298 4251002 D negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 4250298..4251002 Escherichia coli IAI1 7126186 YP_002389441.1 CDS yijD NC_011741.1 4251002 4251361 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4251002..4251361 Escherichia coli IAI1 7127059 YP_002389442.1 CDS trmA NC_011741.1 4251401 4252501 R catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase complement(4251401..4252501) Escherichia coli IAI1 7125352 YP_002389443.1 CDS btuB NC_011741.1 4252870 4254714 D involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 4252870..4254714 Escherichia coli IAI1 7125504 YP_002389444.1 CDS murI NC_011741.1 4254659 4255516 D converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 4254659..4255516 Escherichia coli IAI1 7124423 YP_002389445.1 CDS murB NC_011741.1 4261202 4262230 D catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 4261202..4262230 Escherichia coli IAI1 7125486 YP_002389446.1 CDS birA NC_011741.1 4262227 4263192 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 4262227..4263192 Escherichia coli IAI1 7124493 YP_002389447.1 CDS coaA NC_011741.1 4263221 4264171 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(4263221..4264171) Escherichia coli IAI1 7124414 YP_002389448.1 CDS tufB NC_011741.1 4265089 4266273 D EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4265089..4266273 Escherichia coli IAI1 7128022 YP_002389449.1 CDS secE NC_011741.1 4266503 4266886 D forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 4266503..4266886 Escherichia coli IAI1 7127517 YP_002389450.1 CDS nusG NC_011741.1 4266888 4267433 D Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 4266888..4267433 Escherichia coli IAI1 7124694 YP_002389451.1 CDS rplK NC_011741.1 4267592 4268020 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 4267592..4268020 Escherichia coli IAI1 7125975 YP_002389452.1 CDS rplA NC_011741.1 4268024 4268728 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 4268024..4268728 Escherichia coli IAI1 7128372 YP_002389453.1 CDS rplJ NC_011741.1 4269141 4269638 D binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 4269141..4269638 Escherichia coli IAI1 7128618 YP_002389454.1 CDS rplL NC_011741.1 4269705 4270070 D present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 4269705..4270070 Escherichia coli IAI1 7128371 YP_002389455.1 CDS rpoB NC_011741.1 4270390 4274418 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 4270390..4274418 Escherichia coli IAI1 7128373 YP_002389456.1 CDS rpoC NC_011741.1 4274495 4278718 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 4274495..4278718 Escherichia coli IAI1 7128397 YP_002389457.1 CDS htrC NC_011741.1 4278931 4279470 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264341, 92021792, 2160943; Product type f : factor; heat shock protein 4278931..4279470 Escherichia coli IAI1 7128398 YP_002389458.1 CDS thiH NC_011741.1 4279880 4281013 R in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH complement(4279880..4281013) Escherichia coli IAI1 7127978 YP_002389459.1 CDS thiG NC_011741.1 4281010 4281780 R functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase complement(4281010..4281780) Escherichia coli IAI1 7126245 YP_002389460.1 CDS thiS NC_011741.1 4281782 4281982 R with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS complement(4281782..4281982) Escherichia coli IAI1 7126244 YP_002389461.1 CDS thiF NC_011741.1 4281966 4282721 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8432721, 94089392, 98298179, 10082377, 9632726; Product type e : enzyme; thiamin (thiazole moiety) biosynthesis protein complement(4281966..4282721) Escherichia coli IAI1 7126251 YP_002389462.1 CDS thiE NC_011741.1 4282714 4283349 R catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase complement(4282714..4283349) Escherichia coli IAI1 7126243 YP_002389463.1 CDS thiC NC_011741.1 4283349 4285244 R required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC complement(4283349..4285244) Escherichia coli IAI1 7126242 YP_002389464.1 CDS rsd NC_011741.1 4285477 4285953 R binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor complement(4285477..4285953) Escherichia coli IAI1 7125505 YP_002389465.1 CDS nudC NC_011741.1 4286048 4286821 D can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 4286048..4286821 Escherichia coli IAI1 7128431 YP_002389466.1 CDS hemE NC_011741.1 4286861 4287925 D catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 4286861..4287925 Escherichia coli IAI1 7125952 YP_002389467.1 CDS nfi NC_011741.1 4287935 4288606 D Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 4287935..4288606 Escherichia coli IAI1 7128509 YP_002389468.1 CDS yjaG NC_011741.1 4288649 4289239 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4288649..4289239 Escherichia coli IAI1 7127867 YP_002389469.1 CDS hupA NC_011741.1 4289426 4289698 D histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 4289426..4289698 Escherichia coli IAI1 7125358 YP_002389470.1 CDS yjaH NC_011741.1 4289711 4290406 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4289711..4290406 Escherichia coli IAI1 7125324 YP_002389471.1 CDS zraP NC_011741.1 4290408 4290833 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98362023, 9694902; Product type pf : putative factor; zinc resistance protein complement(4290408..4290833) Escherichia coli IAI1 7125359 YP_002389472.1 CDS zraS NC_011741.1 4291071 4292447 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21140164, 89327164, 92255260, 11243806, 2666400; Product type r : regulator; sensor protein ZraS 4291071..4292447 Escherichia coli IAI1 7128131 YP_002389473.1 CDS zraR NC_011741.1 4292444 4293769 D DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 4292444..4293769 Escherichia coli IAI1 7128133 YP_002389474.1 CDS purD NC_011741.1 4293766 4295055 R catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase complement(4293766..4295055) Escherichia coli IAI1 7128132 YP_002389475.1 CDS purH NC_011741.1 4295067 4296656 R involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase complement(4295067..4296656) Escherichia coli IAI1 7126547 YP_002389476.1 CDS yjaB NC_011741.1 4302400 4302843 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; hypothetical protein complement(4302400..4302843) Escherichia coli IAI1 7125487 YP_002389477.1 CDS metA NC_011741.1 4303000 4303929 D catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 4303000..4303929 Escherichia coli IAI1 7125357 YP_002389478.1 CDS aceB NC_011741.1 4304198 4305799 D Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 4304198..4305799 Escherichia coli IAI1 7124242 YP_002389479.1 CDS aceA NC_011741.1 4305829 4307133 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91295197, 92112731, 92353108, 2836370, 3049537, 3060852, 3276689, 3290857, 3291954, 7826335; Product type e : enzyme; isocitrate lyase 4305829..4307133 Escherichia coli IAI1 7125695 YP_002389480.1 CDS ECIAI1_4236 NC_011741.1 4307202 4307438 D Evidence 6 : Doubtful CDS; hypothetical protein 4307202..4307438 Escherichia coli IAI1 7125694 YP_002389481.1 CDS aceK NC_011741.1 4307414 4309150 D catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol; bifunctional isocitrate dehydrogenase kinase/phosphatase protein 4307414..4309150 Escherichia coli IAI1 7125667 YP_002389482.1 CDS iclR NC_011741.1 4311010 4311834 R regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; transcriptional repressor IclR complement(4311010..4311834) Escherichia coli IAI1 7125815 YP_002389483.1 CDS metH NC_011741.1 4312034 4315717 D one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 4312034..4315717 Escherichia coli IAI1 7126044 YP_002389484.1 CDS yjbB NC_011741.1 4315937 4317568 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4315937..4317568 Escherichia coli IAI1 7124248 YP_002389485.1 CDS pepE NC_011741.1 4317659 4318348 R alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E complement(4317659..4318348) Escherichia coli IAI1 7125361 YP_002389486.1 CDS yjbC NC_011741.1 4318560 4319432 D catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 4318560..4319432 Escherichia coli IAI1 7124172 YP_002389487.1 CDS yjbD NC_011741.1 4319433 4319705 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4319433..4319705) Escherichia coli IAI1 7125362 YP_002389488.1 CDS ECIAI1_4246 NC_011741.1 4320235 4321362 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4320235..4321362 Escherichia coli IAI1 7125363 YP_002389489.1 CDS ECIAI1_4247 NC_011741.1 4321359 4322159 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4321359..4322159 Escherichia coli IAI1 7125668 YP_002389490.1 CDS ECIAI1_4248 NC_011741.1 4322195 4323127 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative zeta toxin; poison-antidote element complement(4322195..4323127) Escherichia coli IAI1 7125669 YP_002389491.1 CDS lysC NC_011741.1 4323266 4324615 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase III complement(4323266..4324615) Escherichia coli IAI1 7125670 YP_002389492.1 CDS pgi NC_011741.1 4325140 4326789 D functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 4325140..4326789 Escherichia coli IAI1 7125506 YP_002389493.1 CDS ECIAI1_4251 NC_011741.1 4327125 4327373 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4327125..4327373) Escherichia coli IAI1 7124185 YP_002389494.1 CDS yjbF NC_011741.1 4327500 4328138 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 4327500..4328138 Escherichia coli IAI1 7127531 YP_002389495.1 CDS yjbG NC_011741.1 4328135 4328872 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4328135..4328872 Escherichia coli IAI1 7125364 YP_002389496.1 CDS yjbH NC_011741.1 4328872 4330968 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative porin 4328872..4330968 Escherichia coli IAI1 7125365 YP_002389497.1 CDS ECIAI1_4255 NC_011741.1 4330972 4331133 D Evidence 6 : Doubtful CDS; hypothetical protein 4330972..4331133 Escherichia coli IAI1 7125366 YP_002389498.1 CDS ECIAI1_4256 NC_011741.1 4331015 4331293 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4331015..4331293) Escherichia coli IAI1 7125430 YP_002389499.1 CDS ECIAI1_4257 NC_011741.1 4331353 4331511 D Evidence 6 : Doubtful CDS; hypothetical protein 4331353..4331511 Escherichia coli IAI1 7125431 YP_002389500.1 CDS yjbA NC_011741.1 4331508 4331918 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10986267; Product type pm : putative membrane component; phosphate-starvation-inducible protein PsiE 4331508..4331918 Escherichia coli IAI1 7125432 YP_002389501.1 CDS xylE NC_011741.1 4331962 4333437 R xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter; D-xylose transporter XylE complement(4331962..4333437) Escherichia coli IAI1 7125360 YP_002389502.1 CDS malG NC_011741.1 4333809 4334699 R with MalKFE is involved in the transport of maltose into the cell; maltose transporter permease complement(4333809..4334699) Escherichia coli IAI1 7126479 YP_002389503.1 CDS malF NC_011741.1 4334714 4336258 R with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein complement(4334714..4336258) Escherichia coli IAI1 7127656 YP_002389504.1 CDS malE NC_011741.1 4336412 4337602 R functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter periplasmic protein complement(4336412..4337602) Escherichia coli IAI1 7127655 YP_002389505.1 CDS malK NC_011741.1 4337967 4339082 D with malEFG is involved in import of maltose/maltodextrin; maltose/maltodextrin transporter ATP-binding protein 4337967..4339082 Escherichia coli IAI1 7127654 YP_002389506.1 CDS lamB NC_011741.1 4339154 4340494 D porin involved in the transport of maltose and maltodextrins; maltoporin 4339154..4340494 Escherichia coli IAI1 7127658 YP_002389507.1 CDS malM NC_011741.1 4340646 4341566 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87141162, 2434655, 6086106; Product type pt : putative transporter; maltose regulon periplasmic protein 4340646..4341566 Escherichia coli IAI1 7126396 YP_002389508.1 CDS ECIAI1_4267 NC_011741.1 4341792 4341986 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4341792..4341986 Escherichia coli IAI1 7127659 YP_002389509.1 CDS yjbI NC_011741.1 4342044 4343372 D in E. coli, some yjbl mutations have been reported as suppressors of dnaG mutations; hypothetical protein 4342044..4343372 Escherichia coli IAI1 7125433 YP_002389510.1 CDS ubiC NC_011741.1 4343595 4344092 D catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 4343595..4344092 Escherichia coli IAI1 7125367 YP_002389511.1 CDS ubiA NC_011741.1 4344105 4344977 D catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 4344105..4344977 Escherichia coli IAI1 7125511 YP_002389512.1 CDS plsB NC_011741.1 4345132 4347555 R PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase complement(4345132..4347555) Escherichia coli IAI1 7124380 YP_002389513.1 CDS dgkA NC_011741.1 4347726 4348094 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10220339, 6257698, 86278195, 88111690, 2984194, 6309817, 8071224; Product type e : enzyme; diacylglycerol kinase 4347726..4348094 Escherichia coli IAI1 7126099 YP_002389514.1 CDS lexA NC_011741.1 4348204 4348812 D Represses a number of genes involved in the response to DNA damage; LexA repressor 4348204..4348812 Escherichia coli IAI1 7124571 YP_002389515.1 CDS dinF NC_011741.1 4348831 4350210 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87165788; Product type cp : cell process; DNA-damage-inducible SOS response protein 4348831..4350210 Escherichia coli IAI1 7126414 YP_002389516.1 CDS yjbJ NC_011741.1 4350326 4350535 D unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; putative stress-response protein 4350326..4350535 Escherichia coli IAI1 7124588 YP_002389517.1 CDS zur NC_011741.1 4350577 4351092 R Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor complement(4350577..4351092) Escherichia coli IAI1 7125368 YP_002389518.1 CDS yjbL NC_011741.1 4351410 4351664 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4351410..4351664 Escherichia coli IAI1 7128135 YP_002389519.1 CDS yjbM NC_011741.1 4351688 4352395 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4351688..4352395 Escherichia coli IAI1 7125369 YP_002389520.1 CDS yjbN NC_011741.1 4352758 4353795 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566; Product type e : enzyme; tRNA-dihydrouridine synthase A 4352758..4353795 Escherichia coli IAI1 7125370 YP_002389521.1 CDS pspG NC_011741.1 4353719 4354171 D coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 4353719..4354171 Escherichia coli IAI1 7125371 YP_002389522.1 CDS qor NC_011741.1 4354337 4355320 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94089392, 7602590; Product type e : enzyme; quinone oxidoreductase complement(4354337..4355320) Escherichia coli IAI1 7125372 YP_002389523.1 CDS dnaB NC_011741.1 4355403 4356818 D unwinds double stranded DNA; replicative DNA helicase 4355403..4356818 Escherichia coli IAI1 7126579 YP_002389524.1 CDS alr NC_011741.1 4356871 4357950 D converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 4356871..4357950 Escherichia coli IAI1 7124605 YP_002389525.1 CDS tyrB NC_011741.1 4358203 4359396 D catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 4358203..4359396 Escherichia coli IAI1 7124781 YP_002389526.1 CDS ECIAI1_4286 NC_011741.1 4359618 4360160 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4359618..4360160) Escherichia coli IAI1 7127526 YP_002389527.1 CDS aphA NC_011741.1 4360523 4361236 D Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 4360523..4361236 Escherichia coli IAI1 7125434 YP_002389528.1 CDS yjbQ NC_011741.1 4361347 4361763 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11972052; hypothetical protein 4361347..4361763 Escherichia coli IAI1 7125769 YP_002389529.1 CDS yjbR NC_011741.1 4361767 4362123 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4361767..4362123 Escherichia coli IAI1 7125373 YP_002389530.1 CDS uvrA NC_011741.1 4362158 4364980 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A complement(4362158..4364980) Escherichia coli IAI1 7125374 YP_002389531.1 CDS ssb NC_011741.1 4365234 4365770 D binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 4365234..4365770 Escherichia coli IAI1 7125555 YP_002389532.1 CDS yjcB NC_011741.1 4365869 4366150 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4365869..4366150) Escherichia coli IAI1 7127979 YP_002389533.1 CDS yjcC NC_011741.1 4366580 4368166 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative signal transduction protein 4366580..4368166 Escherichia coli IAI1 7125375 YP_002389534.1 CDS soxS NC_011741.1 4368169 4368492 R regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS complement(4368169..4368492) Escherichia coli IAI1 7125376 YP_002389535.1 CDS soxR NC_011741.1 4368578 4369042 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91210176, 91360349, 94139656, 9564045, 10207625, 12670967, 1653416, 1708380, 7673113, 8065907, 8306957, 8631739, 8969171, 9019397, 9092651, 9204707; Product type r : regulator; DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing 4368578..4369042 Escherichia coli IAI1 7127950 YP_002389536.1 CDS yjcD NC_011741.1 4369588 4370937 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease 4369588..4370937 Escherichia coli IAI1 7124666 YP_002389537.1 CDS yjcE NC_011741.1 4371088 4372737 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 21557160, 11479290; Product type pt : putative transporter; putative cation/proton antiporter 4371088..4372737 Escherichia coli IAI1 7125377 YP_002389538.1 CDS yjcF NC_011741.1 4372891 4374183 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4372891..4374183) Escherichia coli IAI1 7125378 YP_002389539.1 CDS actP NC_011741.1 4374361 4376010 R member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease complement(4374361..4376010) Escherichia coli IAI1 7125379 YP_002389540.1 CDS yjcH NC_011741.1 4376007 4376321 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14563880; Product type pm : putative membrane component; hypothetical protein complement(4376007..4376321) Escherichia coli IAI1 7125713 YP_002389541.1 CDS acs NC_011741.1 4376521 4378479 R Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase complement(4376521..4378479) Escherichia coli IAI1 7125380 YP_002389542.1 CDS nrfA NC_011741.1 4378872 4380308 D catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 4378872..4380308 Escherichia coli IAI1 7125712 YP_002389543.1 CDS nrfB NC_011741.1 4380353 4380919 D part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 4380353..4380919 Escherichia coli IAI1 7125942 YP_002389544.1 CDS nrfC NC_011741.1 4380916 4381587 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94335626, 8057835; Product type c : carrier; formate-dependent nitrite reductase, 4Fe4S subunit 4380916..4381587 Escherichia coli IAI1 7125943 YP_002389545.1 CDS nrfD NC_011741.1 4381584 4382540 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 8057835; Product type e : enzyme; formate-dependent nitrite reductase, membrane subunit 4381584..4382540 Escherichia coli IAI1 7125944 YP_002389546.1 CDS nrfE NC_011741.1 4382620 4384278 D with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 4382620..4384278 Escherichia coli IAI1 7125945 YP_002389547.1 CDS nrfF NC_011741.1 4384271 4384654 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 9593308, 8057835, 8842153; Product type f : factor; formate-dependent nitrite reductase complex subunit NrfF 4384271..4384654 Escherichia coli IAI1 7125946 YP_002389548.1 CDS nrfG NC_011741.1 4384651 4385247 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 9593308, 8057835, 8842153; Product type f : factor; formate-dependent nitrite reductase complex subunit NrfG 4384651..4385247 Escherichia coli IAI1 7125947 YP_002389549.1 CDS gltP NC_011741.1 4385589 4386902 D carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 4385589..4386902 Escherichia coli IAI1 7125948 YP_002389550.1 CDS yjcO NC_011741.1 4386980 4387669 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4386980..4387669) Escherichia coli IAI1 7128353 YP_002389551.1 CDS fdhF NC_011741.1 4387763 4389910 R Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-H, selenopolypeptide subunit complement(4387763..4389910) Escherichia coli IAI1 7125381 YP_002389552.1 CDS yjcP NC_011741.1 4390108 4391574 R part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; putative outer membrane efflux protein MdtP complement(4390108..4391574) Escherichia coli IAI1 7127074 YP_002389553.1 CDS yjcQ NC_011741.1 4391571 4393622 R possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO complement(4391571..4393622) Escherichia coli IAI1 7125382 YP_002389554.1 CDS yjcR NC_011741.1 4393622 4394653 R with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN complement(4393622..4394653) Escherichia coli IAI1 7125383 YP_002389555.1 CDS ECIAI1_4318 NC_011741.1 4394672 4394995 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4394672..4394995) Escherichia coli IAI1 7125384 YP_002389556.1 CDS yjcS NC_011741.1 4395156 4397141 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1587481; Product type pe : putative enzyme; putative alkyl sulfatase complement(4395156..4397141) Escherichia coli IAI1 7125435 YP_002389557.1 CDS ECIAI1_4320 NC_011741.1 4397394 4397711 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ribose-5-phosphate isomerase B (rpiB-like) 4397394..4397711 Escherichia coli IAI1 7125385 YP_002389558.1 CDS yjdP NC_011741.1 4397780 4398109 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4397780..4398109 Escherichia coli IAI1 7125436 YP_002389559.1 CDS phnP NC_011741.1 4398256 4399014 R required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein complement(4398256..4399014) Escherichia coli IAI1 7125395 YP_002389560.1 CDS phnO NC_011741.1 4399016 4399450 R PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase complement(4399016..4399450) Escherichia coli IAI1 7124213 YP_002389561.1 CDS phnN NC_011741.1 4399437 4399994 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12700258, 91100346, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; ribose 1,5-bisphosphokinase complement(4399437..4399994) Escherichia coli IAI1 7124212 YP_002389562.1 CDS phnM NC_011741.1 4399994 4401130 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100346, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4399994..4401130) Escherichia coli IAI1 7124211 YP_002389563.1 CDS phnL NC_011741.1 4401127 4401807 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4401127..4401807) Escherichia coli IAI1 7124210 YP_002389564.1 CDS phnK NC_011741.1 4401918 4402676 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; phosphonate C-P lyase system protein PhnK complement(4401918..4402676) Escherichia coli IAI1 7124209 YP_002389565.1 CDS phnJ NC_011741.1 4402673 4403518 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4402673..4403518) Escherichia coli IAI1 7124208 YP_002389566.1 CDS phnI NC_011741.1 4403511 4404575 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4403511..4404575) Escherichia coli IAI1 7124207 YP_002389567.1 CDS phnH NC_011741.1 4404575 4405159 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4404575..4405159) Escherichia coli IAI1 7124206 YP_002389568.1 CDS phnG NC_011741.1 4405156 4405608 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4405156..4405608) Escherichia coli IAI1 7124205 YP_002389569.1 CDS phnF NC_011741.1 4405609 4406334 R may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF complement(4405609..4406334) Escherichia coli IAI1 7124204 YP_002389570.1 CDS phnE NC_011741.1 4406355 4407134 R Evidence 2b : Function of strongly homologous gene; Product type t : transporter; phosphonates transport system, permease complement(4406355..4407134) Escherichia coli IAI1 7124203 YP_002389571.1 CDS phnD NC_011741.1 4407196 4408212 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type t : transporter; phosphonate/organophosphate ester ABC transporter periplasmic-binding protein complement(4407196..4408212) Escherichia coli IAI1 7124202 YP_002389572.1 CDS phnC NC_011741.1 4408237 4409025 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type t : transporter; phosphonate/organophosphate ester transporter subunit complement(4408237..4409025) Escherichia coli IAI1 7124201 YP_002389573.1 CDS phnB NC_011741.1 4409158 4409601 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 93328121, 9650256, 2155230; hypothetical protein complement(4409158..4409601) Escherichia coli IAI1 7124200 YP_002389574.1 CDS phnA NC_011741.1 4409761 4410096 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 93328121, 9650256, 2155230; hypothetical protein complement(4409761..4410096) Escherichia coli IAI1 7124199 YP_002389575.1 CDS yjdA NC_011741.1 4410498 4412726 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4410498..4412726 Escherichia coli IAI1 7124198 YP_002389576.1 CDS yjcZ NC_011741.1 4412723 4413601 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4412723..4413601 Escherichia coli IAI1 7125387 YP_002389577.1 CDS proP NC_011741.1 4413865 4415367 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10049386, 12525168, 92165733, 93132799, 9871325, 99376621, 8421314; Product type t : transporter; proline/glycine betaine transporter 4413865..4415367 Escherichia coli IAI1 7125386 YP_002389578.1 CDS basS NC_011741.1 4415544 4416635 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94110256, 8282725; Product type r : regulator; sensor protein BasS/PmrB complement(4415544..4416635) Escherichia coli IAI1 7126159 YP_002389579.1 CDS basR NC_011741.1 4416645 4417313 R response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR complement(4416645..4417313) Escherichia coli IAI1 7124382 YP_002389580.1 CDS eptA NC_011741.1 4417310 4418953 R with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; putative cell division protein complement(4417310..4418953) Escherichia coli IAI1 7124381 YP_002389581.1 CDS adiC NC_011741.1 4419057 4420394 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12867448; Product type t : transporter; arginine:agmatin antiporter complement(4419057..4420394) Escherichia coli IAI1 7125086 YP_002389582.1 CDS adiY NC_011741.1 4420531 4421292 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : c; Product type r : regulator; DNA-binding transcriptional activator complement(4420531..4421292) Escherichia coli IAI1 7125720 YP_002389583.1 CDS adiA NC_011741.1 4421617 4423887 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93186686, 2830169, 4204273, 8383109; Product type e : enzyme; biodegradative arginine decarboxylase complement(4421617..4423887) Escherichia coli IAI1 7125721 YP_002389584.1 CDS melR NC_011741.1 4424083 4424991 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90060832, 9108148, 1445207, 2684786, 2830169; Product type r : regulator; DNA-binding transcriptional regulator MelR complement(4424083..4424991) Escherichia coli IAI1 7125719 YP_002389585.1 CDS melA NC_011741.1 4425274 4426629 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87174747, 88162811, 90248411, 2831880, 3031590, 6329200; Product type e : enzyme; alpha-galactosidase 4425274..4426629 Escherichia coli IAI1 7124234 YP_002389586.1 CDS melB NC_011741.1 4426744 4428153 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14757226, 90241878, 92297631, 93155159, 1730719, 1872836, 6323466, 8672452; Product type t : transporter; melibiose:sodium symporter 4426744..4428153 Escherichia coli IAI1 7124232 YP_002389587.1 CDS yjdF NC_011741.1 4428292 4428921 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4428292..4428921) Escherichia coli IAI1 7124233 YP_002389588.1 CDS fumB NC_011741.1 4429044 4430690 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86142617, 88193096, 89255123, 2656658; Product type e : enzyme; anaerobic class I fumarate hydratase complement(4429044..4430690) Escherichia coli IAI1 7125389 YP_002389589.1 CDS dcuB NC_011741.1 4430768 4432108 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter complement(4430768..4432108) Escherichia coli IAI1 7128253 YP_002389590.1 CDS dcuR NC_011741.1 4432679 4433398 R response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR complement(4432679..4433398) Escherichia coli IAI1 7126928 YP_002389591.1 CDS dcuS NC_011741.1 4433395 4435026 R C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS complement(4433395..4435026) Escherichia coli IAI1 7124545 YP_002389592.1 CDS yjdI NC_011741.1 4435207 4435437 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4435207..4435437 Escherichia coli IAI1 7124546 YP_002389593.1 CDS yjdJ NC_011741.1 4435449 4435721 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyltransferase with acyl-CoA N-acyltransferase domain 4435449..4435721 Escherichia coli IAI1 7125390 YP_002389594.1 CDS yjdK NC_011741.1 4435948 4436244 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4435948..4436244 Escherichia coli IAI1 7125391 YP_002389595.1 CDS yjdO NC_011741.1 4436272 4436445 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4436272..4436445 Escherichia coli IAI1 7125392 YP_002389596.1 CDS lysU NC_011741.1 4436564 4438081 R class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(4436564..4438081) Escherichia coli IAI1 7125394 YP_002389597.1 CDS yjdL NC_011741.1 4438318 4439775 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(4438318..4439775) Escherichia coli IAI1 7127647 YP_002389598.1 CDS cadA NC_011741.1 4439834 4441981 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92105022, 92210511, 1370290, 1556085, 4204273; Product type e : enzyme; lysine decarboxylase 1 complement(4439834..4441981) Escherichia coli IAI1 7125393 YP_002389599.1 CDS cadB NC_011741.1 4442061 4443395 R antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein; lysine/cadaverine antiporter complement(4442061..4443395) Escherichia coli IAI1 7124437 YP_002389600.1 CDS cadC NC_011741.1 4443761 4445299 R regulates the cadBA operon; DNA-binding transcriptional activator CadC complement(4443761..4445299) Escherichia coli IAI1 7124438 YP_002389601.1 CDS ECIAI1_4367 NC_011741.1 4445586 4445804 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4445586..4445804 Escherichia coli IAI1 7124439 YP_002389602.1 CDS yjdC NC_011741.1 4446098 4446673 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1370290; Product type pr : putative regulator; putative transcriptional regulator complement(4446098..4446673) Escherichia coli IAI1 7128032 YP_002389603.1 CDS dipZ NC_011741.1 4446710 4448407 R two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein complement(4446710..4448407) Escherichia coli IAI1 7125388 YP_002389604.1 CDS cutA NC_011741.1 4448383 4448721 R copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA complement(4448383..4448721) Escherichia coli IAI1 7124592 YP_002389605.1 CDS dcuA NC_011741.1 4448837 4450138 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter complement(4448837..4450138) Escherichia coli IAI1 7126865 YP_002389606.1 CDS aspA NC_011741.1 4450256 4451692 R catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase complement(4450256..4451692) Escherichia coli IAI1 7126927 YP_002389607.1 CDS fxsA NC_011741.1 4452029 4452505 D F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA 4452029..4452505 Escherichia coli IAI1 7126265 YP_002389608.1 CDS yjeH NC_011741.1 4452521 4453777 R uncharacterized member of the APC superfamily of amino acid transporters; unknown function; inner membrane protein YjeH complement(4452521..4453777) Escherichia coli IAI1 7128257 YP_002389609.1 CDS groES NC_011741.1 4454053 4454346 D 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 4454053..4454346 Escherichia coli IAI1 7125398 YP_002389610.1 CDS groEL NC_011741.1 4454390 4456036 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 4454390..4456036 Escherichia coli IAI1 7128466 YP_002389611.1 CDS yjeI NC_011741.1 4456174 4456527 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4456174..4456527 Escherichia coli IAI1 7128465 YP_002389612.1 CDS ECIAI1_4378 NC_011741.1 4456567 4456716 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4456567..4456716 Escherichia coli IAI1 7125399 YP_002389613.1 CDS ECIAI1_4379 NC_011741.1 4456780 4457760 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 4456780..4457760 Escherichia coli IAI1 7125438 YP_002389614.1 CDS yjeJ NC_011741.1 4458009 4458878 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4458009..4458878) Escherichia coli IAI1 7125439 YP_002389615.1 CDS yjeK NC_011741.1 4459268 4460296 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019591, 10629195; Product type pe : putative enzyme; putative lysine aminomutase complement(4459268..4460296) Escherichia coli IAI1 7125400 YP_002389616.1 CDS efp NC_011741.1 4460338 4460904 D Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 4460338..4460904 Escherichia coli IAI1 7125401 YP_002389617.1 CDS ecnA NC_011741.1 4460956 4461081 D acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex; entericidin A 4460956..4461081 Escherichia coli IAI1 7125053 YP_002389618.1 CDS ECIAI1_4384 NC_011741.1 4461176 4461427 R Evidence 6 : Doubtful CDS; hypothetical protein complement(4461176..4461427) Escherichia coli IAI1 7125044 YP_002389619.1 CDS sugE NC_011741.1 4461513 4461830 D member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations; quaternary ammonium compound-resistance protein SugE 4461513..4461830 Escherichia coli IAI1 7125440 YP_002389620.1 CDS blc NC_011741.1 4461827 4462360 R lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc complement(4461827..4462360) Escherichia coli IAI1 7126199 YP_002389621.1 CDS ampC NC_011741.1 4462449 4463582 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92212899, 97464439, 99421326, 10595535, 6795623, 7041115, 9819201; Product type e : enzyme; beta-lactamase complement(4462449..4463582) Escherichia coli IAI1 7124416 YP_002389622.1 CDS frdD NC_011741.1 4463645 4464004 R in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D complement(4463645..4464004) Escherichia coli IAI1 7125756 YP_002389623.1 CDS frdC NC_011741.1 4464015 4464410 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C complement(4464015..4464410) Escherichia coli IAI1 7127273 YP_002389624.1 CDS frdB NC_011741.1 4464421 4465155 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit complement(4464421..4465155) Escherichia coli IAI1 7127272 YP_002389625.1 CDS frdA NC_011741.1 4465148 4466956 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit complement(4465148..4466956) Escherichia coli IAI1 7127271 YP_002389626.1 CDS poxA NC_011741.1 4467281 4468258 D lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 4467281..4468258 Escherichia coli IAI1 7127270 YP_002389627.1 CDS yjeM NC_011741.1 4468477 4469979 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4468477..4469979 Escherichia coli IAI1 7126122 YP_002389628.1 CDS yjeP NC_011741.1 4470130 4473453 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein complement(4470130..4473453) Escherichia coli IAI1 7125402 YP_002389629.1 CDS psd NC_011741.1 4473475 4474443 R catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase complement(4473475..4474443) Escherichia coli IAI1 7125403 YP_002389630.1 CDS rsgA NC_011741.1 4474540 4475592 R EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase complement(4474540..4475592) Escherichia coli IAI1 7126172 YP_002389631.1 CDS orn NC_011741.1 4475687 4476232 D 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4475687..4476232 Escherichia coli IAI1 7128436 YP_002389632.1 CDS yjeS NC_011741.1 4477011 4478150 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative Fe-S electron transport protein complement(4477011..4478150) Escherichia coli IAI1 7128026 YP_002389633.1 CDS yjeF NC_011741.1 4478149 4479696 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 4478149..4479696 Escherichia coli IAI1 7125404 YP_002389634.1 CDS yjeE NC_011741.1 4479668 4480129 D possibly involved in cell wall synthesis; putative ATPase 4479668..4480129 Escherichia coli IAI1 7125397 YP_002389635.1 CDS amiB NC_011741.1 4480148 4481485 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21348478, 87242501, 1594459, 7511774; Product type e : enzyme; N-acetylmuramoyl-l-alanine amidase II 4480148..4481485 Escherichia coli IAI1 7125396 YP_002389636.1 CDS mutL NC_011741.1 4481495 4483342 D This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 4481495..4483342 Escherichia coli IAI1 7125753 YP_002389637.1 CDS miaA NC_011741.1 4483335 4484285 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 4483335..4484285 Escherichia coli IAI1 7124503 YP_002389638.1 CDS hfq NC_011741.1 4484371 4484679 D Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 4484371..4484679 Escherichia coli IAI1 7124270 YP_002389639.1 CDS hflX NC_011741.1 4484755 4486035 D involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; putative GTPase HflX 4484755..4486035 Escherichia coli IAI1 7128522 YP_002389640.1 CDS hflK NC_011741.1 4486121 4487380 D with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 4486121..4487380 Escherichia coli IAI1 7128521 YP_002389641.1 CDS hflC NC_011741.1 4487383 4488387 D with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 4487383..4488387 Escherichia coli IAI1 7128520 YP_002389642.1 CDS yjeT NC_011741.1 4488469 4488666 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4488469..4488666 Escherichia coli IAI1 7128518 YP_002389643.1 CDS purA NC_011741.1 4488770 4490068 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 4488770..4490068 Escherichia coli IAI1 7125405 YP_002389644.1 CDS nsrR NC_011741.1 4490273 4490698 D negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 4490273..4490698 Escherichia coli IAI1 7126544 YP_002389645.1 CDS rnr NC_011741.1 4490737 4493178 D 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 4490737..4493178 Escherichia coli IAI1 7125949 YP_002389646.1 CDS rlmB NC_011741.1 4493358 4494089 D Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 4493358..4494089 Escherichia coli IAI1 7128611 YP_002389647.1 CDS yjfI NC_011741.1 4494216 4494617 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4494216..4494617 Escherichia coli IAI1 7125006 YP_002389648.1 CDS yjfJ NC_011741.1 4494636 4495334 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator effector protein 4494636..4495334 Escherichia coli IAI1 7125408 YP_002389649.1 CDS yjfK NC_011741.1 4495385 4496044 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4495385..4496044 Escherichia coli IAI1 7125409 YP_002389650.1 CDS yjfL NC_011741.1 4496062 4496460 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4496062..4496460 Escherichia coli IAI1 7125410 YP_002389651.1 CDS yjfM NC_011741.1 4496470 4497108 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4496470..4497108 Escherichia coli IAI1 7125411 YP_002389652.1 CDS yjfC NC_011741.1 4497111 4498274 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative synthetase/amidase 4497111..4498274 Escherichia coli IAI1 7125412 YP_002389653.1 CDS aidB NC_011741.1 4498358 4499983 D catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 4498358..4499983 Escherichia coli IAI1 7125406 YP_002389654.1 CDS yjfN NC_011741.1 4500100 4500375 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4500100..4500375) Escherichia coli IAI1 7125738 YP_002389655.1 CDS yjfO NC_011741.1 4500524 4500853 R in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility; putative biofilm stress and motility protein A complement(4500524..4500853) Escherichia coli IAI1 7125413 YP_002389656.1 CDS yjfP NC_011741.1 4501035 4501784 D YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 4501035..4501784 Escherichia coli IAI1 7125414 YP_002389657.1 CDS ulaR NC_011741.1 4501781 4502536 R negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR complement(4501781..4502536) Escherichia coli IAI1 7125415 YP_002389658.1 CDS ulaG NC_011741.1 4502644 4503708 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12644495, 15808744; Product type pe : putative enzyme; putative L-ascorbate 6-phosphate lactonase complement(4502644..4503708) Escherichia coli IAI1 7125542 YP_002389659.1 CDS ulaA NC_011741.1 4504063 4505460 D membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 4504063..4505460 Escherichia coli IAI1 7125541 YP_002389660.1 CDS ulaB NC_011741.1 4505476 4505781 D involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIB 4505476..4505781 Escherichia coli IAI1 7125535 YP_002389661.1 CDS ulaC NC_011741.1 4505791 4506255 D involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIA 4505791..4506255 Escherichia coli IAI1 7125536 YP_002389662.1 CDS ulaD NC_011741.1 4506269 4506919 D catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 4506269..4506919 Escherichia coli IAI1 7125537 YP_002389663.1 CDS ulaE NC_011741.1 4506929 4507783 D UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 4506929..4507783 Escherichia coli IAI1 7125538 YP_002389664.1 CDS sgaE NC_011741.1 4507783 4508469 D catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4507783..4508469 Escherichia coli IAI1 7125539 YP_002389665.1 CDS yjfY NC_011741.1 4508599 4508874 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4508599..4508874) Escherichia coli IAI1 7125540 YP_002389666.1 CDS rpsF NC_011741.1 4509201 4509596 D binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 4509201..4509596 Escherichia coli IAI1 7125416 YP_002389667.1 CDS priB NC_011741.1 4509603 4509917 D binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 4509603..4509917 Escherichia coli IAI1 7128412 YP_002389668.1 CDS rpsR NC_011741.1 4509922 4510149 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4509922..4510149 Escherichia coli IAI1 7126149 YP_002389669.1 CDS rplI NC_011741.1 4510191 4510640 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4510191..4510640 Escherichia coli IAI1 7128424 YP_002389670.1 CDS yjfZ NC_011741.1 4510711 4511505 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4510711..4511505) Escherichia coli IAI1 7128370 YP_002389671.1 CDS ECIAI1_4438 NC_011741.1 4512128 4512559 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase complement(4512128..4512559) Escherichia coli IAI1 7125417 YP_002389672.1 CDS ydcM NC_011741.1 4512567 4513775 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase 4512567..4513775 Escherichia coli IAI1 7125441 YP_002389673.1 CDS ytfB NC_011741.1 4513910 4514548 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8559074; Product type ps : putative structure; putative cell envelope opacity-associated protein complement(4513910..4514548) Escherichia coli IAI1 7127382 YP_002389674.1 CDS fklB NC_011741.1 4514767 4515387 D FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 4514767..4515387 Escherichia coli IAI1 7128106 YP_002389675.1 CDS cycA NC_011741.1 4515696 4517108 D involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 4515696..4517108 Escherichia coli IAI1 7127206 YP_002389676.1 CDS ytfE NC_011741.1 4517153 4517815 R Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein complement(4517153..4517815) Escherichia coli IAI1 7126873 YP_002389677.1 CDS ytfF NC_011741.1 4517923 4518897 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4517923..4518897) Escherichia coli IAI1 7128107 YP_002389678.1 CDS ytfG NC_011741.1 4518996 4519856 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14747727; Product type e : enzyme; NAD(P)H:quinone oxidoreductase complement(4518996..4519856) Escherichia coli IAI1 7128108 YP_002389679.1 CDS ytfH NC_011741.1 4519945 4520325 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20088838; Product type pr : putative regulator; putative transcriptional regulator 4519945..4520325 Escherichia coli IAI1 7128109 YP_002389680.1 CDS cpdB NC_011741.1 4520454 4522397 R periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein complement(4520454..4522397) Escherichia coli IAI1 7128110 YP_002389681.1 CDS cysQ NC_011741.1 4522587 4523327 D catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 4522587..4523327 Escherichia coli IAI1 7126355 YP_002389682.1 CDS ytfJ NC_011741.1 4523317 4523874 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pr : putative regulator; putative transcriptional regulator complement(4523317..4523874) Escherichia coli IAI1 7126900 YP_002389683.1 CDS ytfK NC_011741.1 4524199 4524405 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4524199..4524405 Escherichia coli IAI1 7128111 YP_002389684.1 CDS ytfL NC_011741.1 4524467 4525810 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4524467..4525810) Escherichia coli IAI1 7128112 YP_002389685.1 CDS msrA NC_011741.1 4526133 4526771 R this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A complement(4526133..4526771) Escherichia coli IAI1 7128113 YP_002389686.1 CDS ytfM NC_011741.1 4526977 4528710 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4526977..4528710 Escherichia coli IAI1 7124481 YP_002389687.1 CDS ytfN NC_011741.1 4528707 4532486 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4528707..4532486 Escherichia coli IAI1 7128114 YP_002389688.1 CDS ytfP NC_011741.1 4532489 4532830 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4532489..4532830 Escherichia coli IAI1 7128115 YP_002389689.1 CDS chpS NC_011741.1 4533042 4533293 D part of the toxin-antitoxin ChpB-ChpS system; antitoxin ChpS 4533042..4533293 Escherichia coli IAI1 7128116 YP_002389690.1 CDS chpB NC_011741.1 4533287 4533637 D toxin of the ChpB-ChpS toxin-antitoxin system; toxin ChpB 4533287..4533637 Escherichia coli IAI1 7126318 YP_002389691.1 CDS ppa NC_011741.1 4533717 4534247 R catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase complement(4533717..4534247) Escherichia coli IAI1 7126316 YP_002389692.1 CDS ytfQ NC_011741.1 4534557 4535513 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pt : putative transporter; putative sugar ABC transporter periplasmic-binding protein 4534557..4535513 Escherichia coli IAI1 7126124 YP_002389693.1 CDS ytfR NC_011741.1 4535653 4537155 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter ATP-binding protein 4535653..4537155 Escherichia coli IAI1 7128117 YP_002389694.1 CDS ytfT NC_011741.1 4537169 4538191 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter membrane protein 4537169..4538191 Escherichia coli IAI1 7128118 YP_002389695.1 CDS yjfF NC_011741.1 4538178 4539173 D membrane component of a putative sugar ABC transporter system; inner membrane ABC transporter permease YjfF 4538178..4539173 Escherichia coli IAI1 7128119 YP_002389696.1 CDS fbp NC_011741.1 4539206 4540204 R catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase complement(4539206..4540204) Escherichia coli IAI1 7125407 YP_002389697.1 CDS mpl NC_011741.1 4540380 4541753 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96404780, 2843822, 7984428, 8808921; Product type e : enzyme; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 4540380..4541753 Escherichia coli IAI1 7127070 YP_002389698.1 CDS yjgA NC_011741.1 4541904 4542455 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4541904..4542455) Escherichia coli IAI1 7124463 YP_002389699.1 CDS pmbA NC_011741.1 4542549 4543901 D protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 4542549..4543901 Escherichia coli IAI1 7125418 YP_002389700.1 CDS cybC NC_011741.1 4544084 4544470 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1761034, 8499452, 10393541; Product type c : carrier; soluble cytochrome b562 4544084..4544470 Escherichia coli IAI1 7126103 YP_002389701.1 CDS nrdG NC_011741.1 4544515 4544979 R activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein complement(4544515..4544979) Escherichia coli IAI1 7126872 YP_002389702.1 CDS nrdD NC_011741.1 4545137 4547275 R Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase complement(4545137..4547275) Escherichia coli IAI1 7125938 YP_002389703.1 CDS treC NC_011741.1 4547669 4549324 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264345, 93302496, 8083158, 8421692; Product type e : enzyme; trehalose-6-phosphate hydrolase complement(4547669..4549324) Escherichia coli IAI1 7127902 YP_002389704.1 CDS treB NC_011741.1 4549374 4550795 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system trehalose(maltose)-specific transporter subunits IIBC complement(4549374..4550795) Escherichia coli IAI1 7127481 YP_002389705.1 CDS treR NC_011741.1 4550914 4551861 R regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor complement(4550914..4551861) Escherichia coli IAI1 7127480 YP_002389706.1 CDS mgtA NC_011741.1 4552240 4554936 D P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 4552240..4554936 Escherichia coli IAI1 7127483 YP_002389707.1 CDS yjgF NC_011741.1 4555142 4555528 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12515541, 10493123, 10595546, 9298646; Product type pe : putative enzyme; ketoacid-binding protein complement(4555142..4555528) Escherichia coli IAI1 7124261 YP_002389708.1 CDS pyrI NC_011741.1 4555601 4556062 R involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase regulatory subunit complement(4555601..4556062) Escherichia coli IAI1 7125421 YP_002389709.1 CDS pyrB NC_011741.1 4556075 4557010 R catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit complement(4556075..4557010) Escherichia coli IAI1 7126576 YP_002389710.1 CDS pyrL NC_011741.1 4557014 4557148 R Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; pyrBI operon leader peptide complement(4557014..4557148) Escherichia coli IAI1 7126569 YP_002389711.1 CDS yjgH NC_011741.1 4557429 4557824 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative mRNA endoribonuclease complement(4557429..4557824) Escherichia coli IAI1 7126577 YP_002389712.1 CDS yjgI NC_011741.1 4557955 4558668 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; oxidoreductase complement(4557955..4558668) Escherichia coli IAI1 7125422 YP_002389713.1 CDS yjgJ NC_011741.1 4558739 4559332 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4558739..4559332 Escherichia coli IAI1 7125423 YP_002389714.1 CDS yjgK NC_011741.1 4559477 4559929 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11115104; hypothetical protein 4559477..4559929 Escherichia coli IAI1 7125424 YP_002389715.1 CDS argI NC_011741.1 4561712 4562716 R catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.; ornithine carbamoyltransferase subunit I complement(4561712..4562716) Escherichia coli IAI1 7126446 YP_002389716.1 CDS yjgD NC_011741.1 4562878 4563294 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4562878..4563294 Escherichia coli IAI1 7125793 YP_002389717.1 CDS yjgM NC_011741.1 4563340 4563843 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase complement(4563340..4563843) Escherichia coli IAI1 7125420 YP_002389718.1 CDS yjgN NC_011741.1 4564036 4565232 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4564036..4565232 Escherichia coli IAI1 7126607 YP_002389719.1 CDS valS NC_011741.1 4565288 4568143 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(4565288..4568143) Escherichia coli IAI1 7126608 YP_002389720.1 CDS holC NC_011741.1 4568143 4568586 R binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi complement(4568143..4568586) Escherichia coli IAI1 7125567 YP_002389721.1 CDS pepA NC_011741.1 4568720 4570231 R catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase complement(4568720..4570231) Escherichia coli IAI1 7125293 YP_002389722.1 CDS yjgP NC_011741.1 4570498 4571598 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4570498..4571598 Escherichia coli IAI1 7124169 YP_002389723.1 CDS yjgQ NC_011741.1 4571598 4572680 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4571598..4572680 Escherichia coli IAI1 7126609 YP_002389724.1 CDS yjgR NC_011741.1 4572799 4574301 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATPase complement(4572799..4574301) Escherichia coli IAI1 7126610 YP_002389725.1 CDS yjgB NC_011741.1 4574431 4575450 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12147722; Product type pe : putative enzyme; putative alcohol dehydrogenase complement(4574431..4575450) Escherichia coli IAI1 7126611 YP_002389726.1 CDS ECIAI1_4496 NC_011741.1 4575525 4575731 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4575525..4575731) Escherichia coli IAI1 7125419 YP_002389727.1 CDS int NC_011741.1 4575920 4577170 D Evidence 2b : Function of strongly homologous gene; PubMedId : 2403440; Product type h : extrachromosomal origin; Prophage integrase 4575920..4577170 Escherichia coli IAI1 7128028 YP_002389728.1 CDS ECIAI1_4498 NC_011741.1 4577258 4578397 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10671450; Product type pe : putative enzyme; putative modification methylase NmeDIP 4577258..4578397 Escherichia coli IAI1 7126072 YP_002389729.1 CDS ECIAI1_4499 NC_011741.1 4578333 4579409 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10671450; Product type pe : putative enzyme; putative type II restriction enzyme NmeDIP 4578333..4579409 Escherichia coli IAI1 7125443 YP_002389730.1 CDS ECIAI1_4500 NC_011741.1 4579551 4580360 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4579551..4580360 Escherichia coli IAI1 7125444 YP_002389731.1 CDS alpA NC_011741.1 4580526 4580732 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage DNA binding protein 4580526..4580732 Escherichia coli IAI1 7125445 YP_002389732.1 CDS ECIAI1_4502 NC_011741.1 4580738 4581067 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4580738..4581067 Escherichia coli IAI1 7125750 YP_002389733.1 CDS ECIAI1_4503 NC_011741.1 4581350 4582552 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative integrase 4581350..4582552 Escherichia coli IAI1 7125446 YP_002389734.1 CDS ECIAI1_4504 NC_011741.1 4582485 4583849 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative integrase 4582485..4583849 Escherichia coli IAI1 7125447 YP_002389735.1 CDS ECIAI1_4505 NC_011741.1 4583846 4585720 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative integrase 4583846..4585720 Escherichia coli IAI1 7125448 YP_002389736.1 CDS ECIAI1_4506 NC_011741.1 4585735 4586121 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4585735..4586121 Escherichia coli IAI1 7125449 YP_002389737.1 CDS ECIAI1_4507 NC_011741.1 4586209 4586643 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4586209..4586643 Escherichia coli IAI1 7125450 YP_002389738.1 CDS ECIAI1_4508 NC_011741.1 4586697 4587011 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4586697..4587011) Escherichia coli IAI1 7125451 YP_002389739.1 CDS ECIAI1_4509 NC_011741.1 4587030 4587416 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4587030..4587416) Escherichia coli IAI1 7125452 YP_002389740.1 CDS ECIAI1_4510 NC_011741.1 4587458 4587730 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(4587458..4587730) Escherichia coli IAI1 7125453 YP_002389741.1 CDS ECIAI1_4511 NC_011741.1 4587954 4589162 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4587954..4589162) Escherichia coli IAI1 7125454 YP_002389742.1 CDS ECIAI1_4513 NC_011741.1 4589122 4589562 R hypothetical protein complement(4589122..4589562) Escherichia coli IAI1 7125455 YP_002389743.1 CDS ECIAI1_4514 NC_011741.1 4589742 4590224 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4589742..4590224 Escherichia coli IAI1 7125456 YP_002389744.1 CDS ECIAI1_4515 NC_011741.1 4590263 4590778 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4590263..4590778 Escherichia coli IAI1 7125457 YP_002389745.1 CDS ECIAI1_4516 NC_011741.1 4590879 4591808 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4590879..4591808) Escherichia coli IAI1 7125458 YP_002389746.1 CDS ECIAI1_4517 NC_011741.1 4591949 4592113 D Evidence 6 : Doubtful CDS; hypothetical protein 4591949..4592113 Escherichia coli IAI1 7125459 YP_002389747.1 CDS ECIAI1_4518 NC_011741.1 4592202 4593098 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(4592202..4593098) Escherichia coli IAI1 7125460 YP_002389748.1 CDS ECIAI1_4519 NC_011741.1 4593108 4594265 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4593108..4594265) Escherichia coli IAI1 7125461 YP_002389749.1 CDS ECIAI1_4520 NC_011741.1 4594262 4596178 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4594262..4596178) Escherichia coli IAI1 7125462 YP_002389750.1 CDS ECIAI1_4521 NC_011741.1 4596824 4597069 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4596824..4597069 Escherichia coli IAI1 7125463 YP_002389751.1 CDS yjhS NC_011741.1 4597258 4598238 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4597258..4598238) Escherichia coli IAI1 7125464 YP_002389752.1 CDS yjhT NC_011741.1 4598303 4599409 R Evidence 4 : Homologs of previously reported genes of unknown function; N-acetylneuraminic acid mutarotase complement(4598303..4599409) Escherichia coli IAI1 7126613 YP_002389753.1 CDS yjhA NC_011741.1 4599429 4600145 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15743943; Product type t : transporter; N-acetylnuraminic acid outer membrane channel protein complement(4599429..4600145) Escherichia coli IAI1 7126614 YP_002389754.1 CDS ECIAI1_4525 NC_011741.1 4600515 4600718 D Evidence 6 : Doubtful CDS; hypothetical protein 4600515..4600718 Escherichia coli IAI1 7126612 YP_002389755.1 CDS ECIAI1_4526 NC_011741.1 4600787 4600948 R Evidence 6 : Doubtful CDS; hypothetical protein complement(4600787..4600948) Escherichia coli IAI1 7125465 YP_002389756.1 CDS ECIAI1_4527 NC_011741.1 4600945 4601340 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4600945..4601340) Escherichia coli IAI1 7125466 YP_002389757.1 CDS fimB NC_011741.1 4601601 4602203 D inversion of on/off regulator of fimA; tyrosine recombinase 4601601..4602203 Escherichia coli IAI1 7125467 YP_002389758.1 CDS fimE NC_011741.1 4602681 4603277 D inversion of on/off regulator of fimA; tyrosine recombinase 4602681..4603277 Escherichia coli IAI1 7127111 YP_002389759.1 CDS fimA NC_011741.1 4603757 4604305 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6146599, 6147250, 90220509, 93106965, 2858471, 6123483; Product type s : structure; major type 1 subunit fimbrin 4603757..4604305 Escherichia coli IAI1 7127114 YP_002389760.1 CDS fimI NC_011741.1 4604370 4604909 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12897022, 11673421, 6147250; Product type s : structure; type 1 pilus biosynthesis fimbrial protein 4604370..4604909 Escherichia coli IAI1 7127110 YP_002389761.1 CDS fimC NC_011741.1 4604946 4605671 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20450729, 90220509, 93155127, 93391362, 1363735, 8104335, 8636962, 9783748; Product type f : factor; chaperone, periplasmic 4604946..4605671 Escherichia coli IAI1 7127118 YP_002389762.1 CDS fimD NC_011741.1 4605738 4608374 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12842468, 90220509, 1970114; Product type f : factor; outer membrane usher protein, type 1 fimbrial synthesis 4605738..4608374 Escherichia coli IAI1 7127112 YP_002389763.1 CDS fimF NC_011741.1 4608384 4608914 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 92394896, 1970114, 2890081; Product type s : structure; minor component of type 1 fimbriae 4608384..4608914 Escherichia coli IAI1 7127113 YP_002389764.1 CDS fimG NC_011741.1 4608927 4609430 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 92394896, 2890081; Product type s : structure; minor component of type 1 fimbriae 4608927..4609430 Escherichia coli IAI1 7127115 YP_002389765.1 CDS fimH NC_011741.1 4609450 4610352 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 93155127, 93391362, 1971261, 2890081, 2900235; Product type s : structure; minor component of type 1 fimbriae 4609450..4610352 Escherichia coli IAI1 7127116 YP_002389766.1 CDS gntP NC_011741.1 4610595 4611938 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96125229, 15516583, 8550444; Product type t : transporter; fructuronate transporter complement(4610595..4611938) Escherichia coli IAI1 7127117 YP_002389767.1 CDS uxuA NC_011741.1 4612278 4613462 D catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 4612278..4613462 Escherichia coli IAI1 7128450 YP_002389768.1 CDS uxuB NC_011741.1 4613543 4615003 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73203083, 77222076, 14401695; Product type e : enzyme; D-mannonate oxidoreductase, NAD-binding 4613543..4615003 Escherichia coli IAI1 7125563 YP_002389769.1 CDS uxuR NC_011741.1 4615218 4615991 D regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 4615218..4615991 Escherichia coli IAI1 7125564 YP_002389770.1 CDS yjiC NC_011741.1 4616132 4616962 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4616132..4616962) Escherichia coli IAI1 7125565 YP_002389771.1 CDS ECIAI1_4542 NC_011741.1 4617526 4617669 D Evidence 6 : Doubtful CDS; hypothetical protein 4617526..4617669 Escherichia coli IAI1 7126616 YP_002389772.1 CDS iraD NC_011741.1 4617635 4618027 D inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS; DNA replication/recombination/repair protein 4617635..4618027 Escherichia coli IAI1 7125468 YP_002389773.1 CDS yjiE NC_011741.1 4618020 4618931 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(4618020..4618931) Escherichia coli IAI1 7126617 YP_002389774.1 CDS iadA NC_011741.1 4618996 4620168 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95181377, 7876157; Product type e : enzyme; isoaspartyl dipeptidase complement(4618996..4620168) Escherichia coli IAI1 7126618 YP_002389775.1 CDS yjiG NC_011741.1 4620181 4620642 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4620181..4620642) Escherichia coli IAI1 7126037 YP_002389776.1 CDS yjiH NC_011741.1 4620639 4621322 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4620639..4621322) Escherichia coli IAI1 7126619 YP_002389777.1 CDS kptA NC_011741.1 4621572 4622126 D in yeast cells this enzyme removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate; functions in tRNA splicing; the function and substrate of bacterial enzymes in organisms that do not perform splicing is unknown; RNA 2'-phosphotransferase-like protein 4621572..4622126 Escherichia coli IAI1 7126620 YP_002389778.1 CDS yjiJ NC_011741.1 4622139 4623317 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4622139..4623317) Escherichia coli IAI1 7126391 YP_002389779.1 CDS yjiK NC_011741.1 4623385 4624353 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4623385..4624353) Escherichia coli IAI1 7126621 YP_002389780.1 CDS ECIAI1_4551 NC_011741.1 4624310 4624567 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4624310..4624567) Escherichia coli IAI1 7126622 YP_002389781.1 CDS hgdC NC_011741.1 4624564 4625331 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8365476, 7607244, 15654892; Product type e : enzyme; ATPase, activator of (R)-hydroxyglutaryl-CoA dehydratase complement(4624564..4625331) Escherichia coli IAI1 7125469 YP_002389782.1 CDS yjiM NC_011741.1 4625341 4626492 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3691501, 11106419; Product type pe : putative enzyme; putative 2-hydroxyglutaryl-CoA dehydratase complement(4625341..4626492) Escherichia coli IAI1 7128523 YP_002389783.1 CDS yjiN NC_011741.1 4626608 4627888 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4626608..4627888) Escherichia coli IAI1 7126623 YP_002389784.1 CDS yjiO NC_011741.1 4627929 4629161 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803; Product type t : transporter; multidrug efflux system protein complement(4627929..4629161) Escherichia coli IAI1 7126624 YP_002389785.1 CDS ECIAI1_4557 NC_011741.1 4629628 4630584 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4629628..4630584 Escherichia coli IAI1 7126625 YP_002389786.1 CDS yjiR NC_011741.1 4630827 4632239 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator/aminotransferase complement(4630827..4632239) Escherichia coli IAI1 7125470 YP_002389787.1 CDS ECIAI1_4559 NC_011741.1 4632382 4632534 D hypothetical protein 4632382..4632534 Escherichia coli IAI1 7126626 YP_002389788.1 CDS yjiS NC_011741.1 4632416 4632580 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4632416..4632580 Escherichia coli IAI1 7125471 YP_002389789.1 CDS ECIAI1_4561 NC_011741.1 4632932 4635472 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1472713, 15128530, 9292993; Product type e : enzyme; Penicillin G acylase 4632932..4635472 Escherichia coli IAI1 7126627 YP_002389790.1 CDS yjiA NC_011741.1 4635550 4636506 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14696199; Product type pe : putative enzyme; putative GTP-binding protein YjiA complement(4635550..4636506) Escherichia coli IAI1 7125472 YP_002389791.1 CDS yjiX NC_011741.1 4636517 4636720 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4636517..4636720) Escherichia coli IAI1 7126615 YP_002389792.1 CDS yjiY NC_011741.1 4636770 4638920 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4636770..4638920) Escherichia coli IAI1 7126628 YP_002389793.1 CDS ECIAI1_4565 NC_011741.1 4639088 4639234 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4639088..4639234) Escherichia coli IAI1 7126629 YP_002389794.1 CDS hpaC NC_011741.1 4639313 4639825 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8077235, 8550403, 10633095; Product type e : enzyme; 4-hydroxyphenylacetate 3-monooxygenase small component complement(4639313..4639825) Escherichia coli IAI1 7125473 YP_002389795.1 CDS hpaB NC_011741.1 4639843 4641405 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8077235, 8550403, 10653707; Product type e : enzyme; 4-hydroxyphenylacetate 3-monooxygenase large component complement(4639843..4641405) Escherichia coli IAI1 7125298 YP_002389796.1 CDS hpaA NC_011741.1 4641656 4642546 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8077235, 8550403; Product type r : regulator; Regulator of the 4HPA-hydroxylase operon complement(4641656..4642546) Escherichia coli IAI1 7125297 YP_002389797.1 CDS ECIAI1_4569 NC_011741.1 4642556 4643992 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8550403, 14744977; Product type pt : putative transporter; putative 4-hydroxyphenylacetate permease hpaX complement(4642556..4643992) Escherichia coli IAI1 7125296 YP_002389798.1 CDS hpaI NC_011741.1 4644107 4645036 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8529896, 8550403; Product type e : enzyme; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase complement(4644107..4645036) Escherichia coli IAI1 7125474 YP_002389799.1 CDS hpaH NC_011741.1 4644906 4645811 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8550403, 9492273; Product type e : enzyme; 2-oxo-hepta-3-ene-1,7-dioic acid hydratase complement(4644906..4645811) Escherichia coli IAI1 7125304 YP_002389800.1 CDS hpaF NC_011741.1 4645820 4646200 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2194841; Product type e : enzyme; 5-carboxymethyl-2-hydroxymuconate delta-isomerase complement(4645820..4646200) Escherichia coli IAI1 7125303 YP_002389801.1 CDS hpaD NC_011741.1 4646210 4647061 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8550403; Product type e : enzyme; 3,4-dihydroxyphenylacetate 2,3-dioxygenase complement(4646210..4647061) Escherichia coli IAI1 7125301 YP_002389802.1 CDS hpaE NC_011741.1 4647063 4648529 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7737515, 2061311, 8550403; Product type e : enzyme; 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase complement(4647063..4648529) Escherichia coli IAI1 7125299 YP_002389803.1 CDS hpaG NC_011741.1 4648526 4649821 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8223600, 8384293, 11863436; Product type e : enzyme; 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase complement(4648526..4649821) Escherichia coli IAI1 7125300 YP_002389804.1 CDS hpaR NC_011741.1 4650006 4650533 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8384293, 8550403; Product type r : regulator; 4-hydroxyphenylacetate degradative operon repressor 4650006..4650533 Escherichia coli IAI1 7125302 YP_002389805.1 CDS tsr NC_011741.1 4650652 4652316 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20015410, 89034150, 91317710, 10466731, 2033064, 6213619, 6402709, 8384293; Product type r : regulator; methyl-accepting chemotaxis protein I, serine sensor receptor 4650652..4652316 Escherichia coli IAI1 7125305 YP_002389806.1 CDS yjiZ NC_011741.1 4652365 4653726 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(4652365..4653726) Escherichia coli IAI1 7127511 YP_002389807.1 CDS yjjM NC_011741.1 4653941 4654855 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(4653941..4654855) Escherichia coli IAI1 7126630 YP_002389808.1 CDS yjjN NC_011741.1 4654994 4656016 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 4654994..4656016 Escherichia coli IAI1 7126635 YP_002389809.1 CDS mdoB NC_011741.1 4656156 4658447 R catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I complement(4656156..4658447) Escherichia coli IAI1 7126636 YP_002389810.1 CDS yjjA NC_011741.1 4658701 4659195 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4658701..4659195) Escherichia coli IAI1 7127683 YP_002389811.1 CDS dnaC NC_011741.1 4659244 4659981 R acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC complement(4659244..4659981) Escherichia coli IAI1 7126631 YP_002389812.1 CDS dnaT NC_011741.1 4659984 4660523 R This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI complement(4659984..4660523) Escherichia coli IAI1 7124606 YP_002389813.2 CDS ECIAI1_4585 NC_011741.1 4660631 4661104 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4660631..4661104) Escherichia coli IAI1 7124613 YP_002389814.1 CDS yjjP NC_011741.1 4661095 4661865 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4661095..4661865) Escherichia coli IAI1 7125475 YP_002389815.1 CDS yjjQ NC_011741.1 4662484 4663209 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4662484..4663209 Escherichia coli IAI1 7126637 YP_002389816.1 CDS bglJ NC_011741.1 4663221 4663844 D regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; DNA-binding transcriptional activator BglJ 4663221..4663844 Escherichia coli IAI1 7126638 YP_002389817.1 CDS fhuF NC_011741.1 4663882 4664670 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11931550, 14756576, 3323834, 9990318; Product type c : carrier; ferric iron reductase involved in ferric hydroximate transport complement(4663882..4664670) Escherichia coli IAI1 7124405 YP_002389818.1 CDS ECIAI1_4590 NC_011741.1 4664700 4665047 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4664700..4665047 Escherichia coli IAI1 7127103 YP_002389819.1 CDS rsmC NC_011741.1 4665676 4666707 R 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase complement(4665676..4666707) Escherichia coli IAI1 7128029 YP_002389820.1 CDS holD NC_011741.1 4666810 4667223 D with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 4666810..4667223 Escherichia coli IAI1 7128438 YP_002389821.1 CDS rimI NC_011741.1 4667192 4667638 D alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 4667192..4667638 Escherichia coli IAI1 7125294 YP_002389822.1 CDS yjjG NC_011741.1 4667653 4668330 D manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 4667653..4668330 Escherichia coli IAI1 7125001 YP_002389823.1 CDS prfC NC_011741.1 4668421 4670010 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 4668421..4670010 Escherichia coli IAI1 7126632 YP_002389824.1 CDS osmY NC_011741.1 4670403 4671008 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1317380, 8253679, 9298646, 9600841; Product type cp : cell process; periplasmic protein 4670403..4671008 Escherichia coli IAI1 7126146 YP_002389825.1 CDS ytjA NC_011741.1 4671117 4671296 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4671117..4671296 Escherichia coli IAI1 7125998 YP_002389826.1 CDS yjjU NC_011741.1 4671418 4672491 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative esterase 4671418..4672491 Escherichia coli IAI1 7128120 YP_002389827.1 CDS yjjV NC_011741.1 4672488 4673270 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative deoxyribonuclease YjjV 4672488..4673270 Escherichia coli IAI1 7126639 YP_002389828.1 CDS yjjW NC_011741.1 4673383 4674246 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative pyruvate formate lyase activating enzyme complement(4673383..4674246) Escherichia coli IAI1 7126640 YP_002389829.1 CDS yjjI NC_011741.1 4674218 4675768 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4674218..4675768) Escherichia coli IAI1 7126641 YP_002389830.1 CDS deoC NC_011741.1 4676026 4676805 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 4676026..4676805 Escherichia coli IAI1 7126633 YP_002389831.1 CDS deoA NC_011741.1 4676932 4678254 D Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 4676932..4678254 Escherichia coli IAI1 7124565 YP_002389832.1 CDS deoB NC_011741.1 4678306 4679529 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 4678306..4679529 Escherichia coli IAI1 7124563 YP_002389833.1 CDS deoD NC_011741.1 4679609 4680328 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 4679609..4680328 Escherichia coli IAI1 7124564 YP_002389834.1 CDS lplA NC_011741.1 4680784 4681800 R Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; lipoate-protein ligase A complement(4680784..4681800) Escherichia coli IAI1 7125477 YP_002389835.1 CDS ytjB NC_011741.1 4681828 4682472 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2684780; hypothetical protein complement(4681828..4682472) Escherichia coli IAI1 7127618 YP_002389836.1 CDS serB NC_011741.1 4682578 4683546 D catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 4682578..4683546 Escherichia coli IAI1 7128121 YP_002389837.1 CDS radA NC_011741.1 4683595 4684977 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 4683595..4684977 Escherichia coli IAI1 7127909 YP_002389838.1 CDS nadR NC_011741.1 4684998 4686230 D catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 4684998..4686230 Escherichia coli IAI1 7126586 YP_002389839.1 CDS ECIAI1_4614 NC_011741.1 4686281 4686430 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4686281..4686430 Escherichia coli IAI1 7124516 YP_002389840.1 CDS yjjK NC_011741.1 4686537 4688204 R ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein complement(4686537..4688204) Escherichia coli IAI1 7125478 YP_002389841.1 CDS slt NC_011741.1 4688415 4690352 D catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 4688415..4690352 Escherichia coli IAI1 7126634 YP_002389842.1 CDS trpR NC_011741.1 4690442 4690768 D When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 4690442..4690768 Escherichia coli IAI1 7127931 YP_002389843.1 CDS ECIAI1_4618 NC_011741.1 4690882 4691862 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family complement(4690882..4691862) Escherichia coli IAI1 7127500 YP_002389844.1 CDS yjjX NC_011741.1 4692132 4692662 R pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase complement(4692132..4692662) Escherichia coli IAI1 7125479 YP_002389845.1 CDS ytjC NC_011741.1 4692705 4693352 D catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 4692705..4693352 Escherichia coli IAI1 7126642 YP_002389846.1 CDS rob NC_011741.1 4693349 4694218 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20264525, 20309711, 93194823, 96405618, 8449900; Product type r : regulator; DNA-binding transcriptional activator complement(4693349..4694218) Escherichia coli IAI1 7128122 YP_002389847.1 CDS creA NC_011741.1 4694429 4694902 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3531171, 8449900; hypothetical protein 4694429..4694902 Escherichia coli IAI1 7128613 YP_002389848.1 CDS creB NC_011741.1 4694915 4695604 D response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 4694915..4695604 Escherichia coli IAI1 7126365 YP_002389849.1 CDS creC NC_011741.1 4695604 4697028 D part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 4695604..4697028 Escherichia coli IAI1 7126366 YP_002389850.1 CDS creD NC_011741.1 4697086 4698438 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88216172, 2835585, 2984198, 3531171; Product type m : membrane component; hypothetical protein 4697086..4698438 Escherichia coli IAI1 7126367 YP_002389851.1 CDS arcA NC_011741.1 4698498 4699214 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15028693, 21167794, 21317451, 91008980, 91358353, 92380937, 9514749, 9632255, 2984198, 7565118, 9298646; Product type r : regulator; two-component response regulator complement(4698498..4699214) Escherichia coli IAI1 7126368 YP_002389852.1 CDS yjtD NC_011741.1 4699850 4700536 D member of the SPOUT superfamily of methyltransferases; putative RNA methyltransferase 4699850..4700536 Escherichia coli IAI1 7125784 ECIAI1_tRNA1 tRNA ECIAI1_tRNA1 NC_011741.1 224740 224816 D tRNA-Ile 224740..224816 Escherichia coli IAI1 7126788 ECIAI1_tRNA2 tRNA ECIAI1_tRNA2 NC_011741.1 224859 224934 D tRNA-Ala 224859..224934 Escherichia coli IAI1 7125507 ECIAI1_tRNA3 tRNA ECIAI1_tRNA3 NC_011741.1 228287 228363 D tRNA-Asp 228287..228363 Escherichia coli IAI1 7125483 ECIAI1_tRNA4 tRNA ECIAI1_tRNA4 NC_011741.1 236511 236587 D tRNA-Asp 236511..236587 Escherichia coli IAI1 7124612 ECIAI1_tRNA5 tRNA ECIAI1_tRNA5 NC_011741.1 300633 300708 D tRNA-Thr 300633..300708 Escherichia coli IAI1 7126156 ECIAI1_tRNA6 tRNA ECIAI1_tRNA6 NC_011741.1 359893 359973 D tRNA-OTHER 359893..359973 Escherichia coli IAI1 7126711 ECIAI1_tRNA7 tRNA ECIAI1_tRNA7 NC_011741.1 579043 579119 D tRNA-Arg 579043..579119 Escherichia coli IAI1 7127119 ECIAI1_tRNA86 tRNA ECIAI1_tRNA86 NC_011741.1 699963 700037 R tRNA-Gln complement(699963..700037) Escherichia coli IAI1 7125514 ECIAI1_tRNA85 tRNA ECIAI1_tRNA85 NC_011741.1 700075 700149 R tRNA-Gln complement(700075..700149) Escherichia coli IAI1 7125671 ECIAI1_tRNA84 tRNA ECIAI1_tRNA84 NC_011741.1 700198 700274 R tRNA-Met complement(700198..700274) Escherichia coli IAI1 7124864 ECIAI1_tRNA83 tRNA ECIAI1_tRNA83 NC_011741.1 700290 700364 R tRNA-Gln complement(700290..700364) Escherichia coli IAI1 7128065 ECIAI1_tRNA82 tRNA ECIAI1_tRNA82 NC_011741.1 700399 700473 R tRNA-Gln complement(700399..700473) Escherichia coli IAI1 7128064 ECIAI1_tRNA81 tRNA ECIAI1_tRNA81 NC_011741.1 700497 700581 R tRNA-Leu complement(700497..700581) Escherichia coli IAI1 7127041 ECIAI1_tRNA80 tRNA ECIAI1_tRNA80 NC_011741.1 700590 700666 R tRNA-Met complement(700590..700666) Escherichia coli IAI1 7128062 ECIAI1_tRNA8 tRNA ECIAI1_tRNA8 NC_011741.1 780570 780645 D tRNA-Lys 780570..780645 Escherichia coli IAI1 7124822 ECIAI1_tRNA9 tRNA ECIAI1_tRNA9 NC_011741.1 780781 780856 D tRNA-Val 780781..780856 Escherichia coli IAI1 7128060 ECIAI1_tRNA10 tRNA ECIAI1_tRNA10 NC_011741.1 780859 780934 D tRNA-Lys 780859..780934 Escherichia coli IAI1 7125672 ECIAI1_tRNA11 tRNA ECIAI1_tRNA11 NC_011741.1 781084 781159 D tRNA-Val 781084..781159 Escherichia coli IAI1 7125508 ECIAI1_tRNA12 tRNA ECIAI1_tRNA12 NC_011741.1 781163 781238 D tRNA-Lys 781163..781238 Escherichia coli IAI1 7125509 ECIAI1_tRNA13 tRNA ECIAI1_tRNA13 NC_011741.1 781385 781460 D tRNA-Lys 781385..781460 Escherichia coli IAI1 7127905 ECIAI1_tRNA14 tRNA ECIAI1_tRNA14 NC_011741.1 781494 781569 D tRNA-Lys 781494..781569 Escherichia coli IAI1 7127987 ECIAI1_tRNA79 tRNA ECIAI1_tRNA79 NC_011741.1 977995 978082 R tRNA-Ser complement(977995..978082) Escherichia coli IAI1 7128631 ECIAI1_tRNA78 tRNA ECIAI1_tRNA78 NC_011741.1 1084066 1084153 R tRNA-Ser complement(1084066..1084153) Escherichia coli IAI1 7128633 ECIAI1_tRNA77 tRNA ECIAI1_tRNA77 NC_011741.1 1139385 1139472 R tRNA-Ser complement(1139385..1139472) Escherichia coli IAI1 7128639 ECIAI1_tRNA76 tRNA ECIAI1_tRNA76 NC_011741.1 1312597 1312681 R tRNA-Tyr complement(1312597..1312681) Escherichia coli IAI1 7124632 ECIAI1_tRNA75 tRNA ECIAI1_tRNA75 NC_011741.1 1312716 1312800 R tRNA-Tyr complement(1312716..1312800) Escherichia coli IAI1 7128056 ECIAI1_tRNA15 tRNA ECIAI1_tRNA15 NC_011741.1 1790472 1790548 D tRNA-Val 1790472..1790548 Escherichia coli IAI1 7127293 ECIAI1_tRNA16 tRNA ECIAI1_tRNA16 NC_011741.1 1790553 1790629 D tRNA-Val 1790553..1790629 Escherichia coli IAI1 7127989 ECIAI1_tRNA74 tRNA ECIAI1_tRNA74 NC_011741.1 2054944 2055030 R tRNA-Leu complement(2054944..2055030) Escherichia coli IAI1 7125205 ECIAI1_tRNA73 tRNA ECIAI1_tRNA73 NC_011741.1 2055043 2055116 R tRNA-Cys complement(2055043..2055116) Escherichia coli IAI1 7128054 ECIAI1_tRNA72 tRNA ECIAI1_tRNA72 NC_011741.1 2055171 2055246 R tRNA-Gly complement(2055171..2055246) Escherichia coli IAI1 7128053 ECIAI1_tRNA71 tRNA ECIAI1_tRNA71 NC_011741.1 2105173 2105262 R tRNA-Ser complement(2105173..2105262) Escherichia coli IAI1 7127599 ECIAI1_tRNA17 tRNA ECIAI1_tRNA17 NC_011741.1 2106254 2106329 D tRNA-Asn 2106254..2106329 Escherichia coli IAI1 7125241 ECIAI1_tRNA70 tRNA ECIAI1_tRNA70 NC_011741.1 2120662 2120737 R tRNA-Asn complement(2120662..2120737) Escherichia coli IAI1 7126830 ECIAI1_tRNA18 tRNA ECIAI1_tRNA18 NC_011741.1 2122486 2122561 D tRNA-Asn 2122486..2122561 Escherichia coli IAI1 7125244 ECIAI1_tRNA19 tRNA ECIAI1_tRNA19 NC_011741.1 2124895 2124970 D tRNA-Asn 2124895..2124970 Escherichia coli IAI1 7124510 ECIAI1_tRNA20 tRNA ECIAI1_tRNA20 NC_011741.1 2346534 2346610 D tRNA-Pro 2346534..2346610 Escherichia coli IAI1 7125145 ECIAI1_tRNA21 tRNA ECIAI1_tRNA21 NC_011741.1 2510204 2510278 D tRNA-Arg 2510204..2510278 Escherichia coli IAI1 7125835 ECIAI1_tRNA69 tRNA ECIAI1_tRNA69 NC_011741.1 2553599 2553674 R tRNA-Ala complement(2553599..2553674) Escherichia coli IAI1 7125842 ECIAI1_tRNA68 tRNA ECIAI1_tRNA68 NC_011741.1 2553714 2553789 R tRNA-Ala complement(2553714..2553789) Escherichia coli IAI1 7128048 ECIAI1_tRNA22 tRNA ECIAI1_tRNA22 NC_011741.1 2556489 2556564 D tRNA-Val 2556489..2556564 Escherichia coli IAI1 7128355 ECIAI1_tRNA23 tRNA ECIAI1_tRNA23 NC_011741.1 2556609 2556684 D tRNA-Val 2556609..2556684 Escherichia coli IAI1 7127997 ECIAI1_tRNA24 tRNA ECIAI1_tRNA24 NC_011741.1 2556731 2556806 D tRNA-Val 2556731..2556806 Escherichia coli IAI1 7127998 ECIAI1_tRNA25 tRNA ECIAI1_tRNA25 NC_011741.1 2556811 2556886 D tRNA-Lys 2556811..2556886 Escherichia coli IAI1 7127999 ECIAI1_tRNA67 tRNA ECIAI1_tRNA67 NC_011741.1 2796434 2796509 R tRNA-Glu complement(2796434..2796509) Escherichia coli IAI1 7127706 ECIAI1_tRNA66 tRNA ECIAI1_tRNA66 NC_011741.1 2830598 2830673 R tRNA-Met complement(2830598..2830673) Escherichia coli IAI1 7128540 ECIAI1_tRNA65 tRNA ECIAI1_tRNA65 NC_011741.1 2862666 2862742 R tRNA-Arg complement(2862666..2862742) Escherichia coli IAI1 7124339 ECIAI1_tRNA64 tRNA ECIAI1_tRNA64 NC_011741.1 2862941 2863017 R tRNA-Arg complement(2862941..2863017) Escherichia coli IAI1 7128044 ECIAI1_tRNA63 tRNA ECIAI1_tRNA63 NC_011741.1 2863081 2863157 R tRNA-Arg complement(2863081..2863157) Escherichia coli IAI1 7128043 ECIAI1_tRNA62 tRNA ECIAI1_tRNA62 NC_011741.1 2863161 2863253 R tRNA-Ser complement(2863161..2863253) Escherichia coli IAI1 7128042 ECIAI1_tRNA26 tRNA ECIAI1_tRNA26 NC_011741.1 2998687 2998763 D tRNA-Met 2998687..2998763 Escherichia coli IAI1 7124281 ECIAI1_tRNA27 tRNA ECIAI1_tRNA27 NC_011741.1 2998797 2998873 D tRNA-Met 2998797..2998873 Escherichia coli IAI1 7128001 ECIAI1_tRNA28 tRNA ECIAI1_tRNA28 NC_011741.1 2998907 2998983 D tRNA-Met 2998907..2998983 Escherichia coli IAI1 7128561 ECIAI1_tRNA61 tRNA ECIAI1_tRNA61 NC_011741.1 3057240 3057313 R tRNA-Gly complement(3057240..3057313) Escherichia coli IAI1 7128572 ECIAI1_tRNA29 tRNA ECIAI1_tRNA29 NC_011741.1 3180271 3180346 D tRNA-Phe 3180271..3180346 Escherichia coli IAI1 7124357 ECIAI1_tRNA30 tRNA ECIAI1_tRNA30 NC_011741.1 3297066 3297141 D tRNA-Met 3297066..3297141 Escherichia coli IAI1 7128723 ECIAI1_tRNA60 tRNA ECIAI1_tRNA60 NC_011741.1 3406884 3406960 R tRNA-Met complement(3406884..3406960) Escherichia coli IAI1 7128745 ECIAI1_tRNA59 tRNA ECIAI1_tRNA59 NC_011741.1 3410743 3410829 R tRNA-Leu complement(3410743..3410829) Escherichia coli IAI1 7128757 ECIAI1_tRNA58 tRNA ECIAI1_tRNA58 NC_011741.1 3504632 3504707 R tRNA-Thr complement(3504632..3504707) Escherichia coli IAI1 7125481 ECIAI1_tRNA57 tRNA ECIAI1_tRNA57 NC_011741.1 3508019 3508094 R tRNA-Ala complement(3508019..3508094) Escherichia coli IAI1 7127705 ECIAI1_tRNA56 tRNA ECIAI1_tRNA56 NC_011741.1 3508137 3508213 R tRNA-Ile complement(3508137..3508213) Escherichia coli IAI1 7128035 ECIAI1_tRNA55 tRNA ECIAI1_tRNA55 NC_011741.1 3773948 3774024 R tRNA-Pro complement(3773948..3774024) Escherichia coli IAI1 7125630 ECIAI1_tRNA31 tRNA ECIAI1_tRNA31 NC_011741.1 3907369 3907459 D tRNA-Sec 3907369..3907459 Escherichia coli IAI1 7128147 ECIAI1_tRNA32 tRNA ECIAI1_tRNA32 NC_011741.1 4019851 4019926 D tRNA-Glu 4019851..4019926 Escherichia coli IAI1 7126789 ECIAI1_tRNA33 tRNA ECIAI1_tRNA33 NC_011741.1 4023288 4023364 D tRNA-Asp 4023288..4023364 Escherichia coli IAI1 7125484 ECIAI1_tRNA34 tRNA ECIAI1_tRNA34 NC_011741.1 4023373 4023448 D tRNA-Trp 4023373..4023448 Escherichia coli IAI1 7128009 ECIAI1_tRNA35 tRNA ECIAI1_tRNA35 NC_011741.1 4058734 4058810 D tRNA-Arg 4058734..4058810 Escherichia coli IAI1 7128182 ECIAI1_tRNA36 tRNA ECIAI1_tRNA36 NC_011741.1 4058869 4058944 D tRNA-His 4058869..4058944 Escherichia coli IAI1 7128011 ECIAI1_tRNA37 tRNA ECIAI1_tRNA37 NC_011741.1 4058965 4059051 D tRNA-Leu 4058965..4059051 Escherichia coli IAI1 7128012 ECIAI1_tRNA38 tRNA ECIAI1_tRNA38 NC_011741.1 4059094 4059170 D tRNA-Pro 4059094..4059170 Escherichia coli IAI1 7128013 ECIAI1_tRNA39 tRNA ECIAI1_tRNA39 NC_011741.1 4117075 4117151 D tRNA-Ile 4117075..4117151 Escherichia coli IAI1 7126790 ECIAI1_tRNA40 tRNA ECIAI1_tRNA40 NC_011741.1 4117194 4117269 D tRNA-Ala 4117194..4117269 Escherichia coli IAI1 7128015 ECIAI1_tRNA41 tRNA ECIAI1_tRNA41 NC_011741.1 4257517 4257592 D tRNA-Glu 4257517..4257592 Escherichia coli IAI1 7126791 ECIAI1_tRNA42 tRNA ECIAI1_tRNA42 NC_011741.1 4264533 4264608 D tRNA-Thr 4264533..4264608 Escherichia coli IAI1 7126342 ECIAI1_tRNA43 tRNA ECIAI1_tRNA43 NC_011741.1 4264617 4264701 D tRNA-Tyr 4264617..4264701 Escherichia coli IAI1 7128019 ECIAI1_tRNA44 tRNA ECIAI1_tRNA44 NC_011741.1 4264818 4264892 D tRNA-Gly 4264818..4264892 Escherichia coli IAI1 7128020 ECIAI1_tRNA45 tRNA ECIAI1_tRNA45 NC_011741.1 4264899 4264974 D tRNA-Thr 4264899..4264974 Escherichia coli IAI1 7128021 ECIAI1_tRNA46 tRNA ECIAI1_tRNA46 NC_011741.1 4298900 4298975 D tRNA-Glu 4298900..4298975 Escherichia coli IAI1 7126792 ECIAI1_tRNA54 tRNA ECIAI1_tRNA54 NC_011741.1 4445916 4445991 R tRNA-Phe complement(4445916..4445991) Escherichia coli IAI1 7125437 ECIAI1_tRNA47 tRNA ECIAI1_tRNA47 NC_011741.1 4476443 4476518 D tRNA-Gly 4476443..4476518 Escherichia coli IAI1 7125994 ECIAI1_tRNA48 tRNA ECIAI1_tRNA48 NC_011741.1 4476555 4476630 D tRNA-Gly 4476555..4476630 Escherichia coli IAI1 7128024 ECIAI1_tRNA49 tRNA ECIAI1_tRNA49 NC_011741.1 4476666 4476741 D tRNA-Gly 4476666..4476741 Escherichia coli IAI1 7128025 ECIAI1_tRNA50 tRNA ECIAI1_tRNA50 NC_011741.1 4575646 4575730 D tRNA-Leu 4575646..4575730 Escherichia coli IAI1 7125442 ECIAI1_tRNA53 tRNA ECIAI1_tRNA53 NC_011741.1 4665086 4665172 R tRNA-Leu complement(4665086..4665172) Escherichia coli IAI1 7125476 ECIAI1_tRNA52 tRNA ECIAI1_tRNA52 NC_011741.1 4665207 4665293 R tRNA-Leu complement(4665207..4665293) Escherichia coli IAI1 7128031 ECIAI1_tRNA51 tRNA ECIAI1_tRNA51 NC_011741.1 4665322 4665408 R tRNA-Leu complement(4665322..4665408) Escherichia coli IAI1 7128030 ECIAI1_16S_3 rRNA ECIAI1_16S_3 NC_011741.1 223130 224671 D ribosomal RNA 16S 223130..224671 Escherichia coli IAI1 7128362 ECIAI1_23S_3 rRNA ECIAI1_23S_3 NC_011741.1 225118 228021 D ribosomal RNA 23S 225118..228021 Escherichia coli IAI1 7127994 ECIAI1_5S_4 rRNA ECIAI1_5S_4 NC_011741.1 228115 228234 D ribosomal RNA 5S 228115..228234 Escherichia coli IAI1 7127707 ECIAI1_5S_3 rRNA ECIAI1_5S_3 NC_011741.1 2793124 2793243 R ribosomal RNA 5S complement(2793124..2793243) Escherichia coli IAI1 7126390 ECIAI1_23S_2 rRNA ECIAI1_23S_2 NC_011741.1 2793337 2796240 R ribosomal RNA 23S complement(2793337..2796240) Escherichia coli IAI1 7125482 ECIAI1_16S_2 rRNA ECIAI1_16S_2 NC_011741.1 2796681 2798222 R ribosomal RNA 16S complement(2796681..2798222) Escherichia coli IAI1 7128046 ECIAI1_5S_2 rRNA ECIAI1_5S_2 NC_011741.1 3504479 3504591 R ribosomal RNA 5S complement(3504479..3504591) Escherichia coli IAI1 7125681 ECIAI1_5S_1 rRNA ECIAI1_5S_1 NC_011741.1 3504720 3504839 R ribosomal RNA 5S complement(3504720..3504839) Escherichia coli IAI1 7128036 ECIAI1_23S_1 rRNA ECIAI1_23S_1 NC_011741.1 3504932 3507835 R ribosomal RNA 23S complement(3504932..3507835) Escherichia coli IAI1 7125480 ECIAI1_16S_1 rRNA ECIAI1_16S_1 NC_011741.1 3508282 3509823 R ribosomal RNA 16S complement(3508282..3509823) Escherichia coli IAI1 7128034 ECIAI1_16S_4 rRNA ECIAI1_16S_4 NC_011741.1 4018224 4019765 D ribosomal RNA 16S 4018224..4019765 Escherichia coli IAI1 7128179 ECIAI1_23S_4 rRNA ECIAI1_23S_4 NC_011741.1 4020120 4023023 D ribosomal RNA 23S 4020120..4023023 Escherichia coli IAI1 7128008 ECIAI1_5S_5 rRNA ECIAI1_5S_5 NC_011741.1 4023116 4023235 D ribosomal RNA 5S 4023116..4023235 Escherichia coli IAI1 7127708 ECIAI1_16S_5 rRNA ECIAI1_16S_5 NC_011741.1 4115465 4117006 D ribosomal RNA 16S 4115465..4117006 Escherichia coli IAI1 7128511 ECIAI1_23S_5 rRNA ECIAI1_23S_5 NC_011741.1 4117453 4120356 D ribosomal RNA 23S 4117453..4120356 Escherichia coli IAI1 7128017 ECIAI1_5S_6 rRNA ECIAI1_5S_6 NC_011741.1 4120449 4120568 D ribosomal RNA 5S 4120449..4120568 Escherichia coli IAI1 7127709 ECIAI1_16S_6 rRNA ECIAI1_16S_6 NC_011741.1 4255890 4257431 D ribosomal RNA 16S 4255890..4257431 Escherichia coli IAI1 7124499 ECIAI1_23S_6 rRNA ECIAI1_23S_6 NC_011741.1 4257786 4260689 D ribosomal RNA 23S 4257786..4260689 Escherichia coli IAI1 7128018 ECIAI1_5S_7 rRNA ECIAI1_5S_7 NC_011741.1 4260782 4260901 D ribosomal RNA 5S 4260782..4260901 Escherichia coli IAI1 7127710 ECIAI1_16S_7 rRNA ECIAI1_16S_7 NC_011741.1 4297273 4298814 D ribosomal RNA 16S 4297273..4298814 Escherichia coli IAI1 7126550 ECIAI1_23S_7 rRNA ECIAI1_23S_7 NC_011741.1 4299169 4302072 D ribosomal RNA 23S 4299169..4302072 Escherichia coli IAI1 7128023 ECIAI1_5S_8 rRNA ECIAI1_5S_8 NC_011741.1 4302165 4302284 D ribosomal RNA 5S 4302165..4302284 Escherichia coli IAI1 7127711