-- dump date 20140619_082410 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_002406049.1 218698420 7150518 189..254 1 NC_011750.1 involved in threonine biosynthesis; controls the expression of the thrLABC operon; thr operon leader peptide 254 thrL 7150518 thrL Escherichia coli IAI39 thr operon leader peptide YP_002406049.1 189 D 585057 CDS YP_002406050.1 218698421 7152980 335..2797 1 NC_011750.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 2797 thrA 7152980 thrA Escherichia coli IAI39 bifunctional aspartokinase I/homoserine dehydrogenase I YP_002406050.1 335 D 585057 CDS YP_002406051.1 218698422 7152977 2799..3731 1 NC_011750.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 3731 thrB 7152977 thrB Escherichia coli IAI39 homoserine kinase YP_002406051.1 2799 D 585057 CDS YP_002406052.1 218698423 7152978 3732..5018 1 NC_011750.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 5018 thrC 7152978 thrC Escherichia coli IAI39 threonine synthase YP_002406052.1 3732 D 585057 CDS YP_002406053.1 218698424 7152979 5232..5528 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5528 yaaX 7152979 yaaX Escherichia coli IAI39 hypothetical protein YP_002406053.1 5232 D 585057 CDS YP_002406054.1 218698425 7153196 complement(5568..6344) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 6344 yaaA 7153196 yaaA Escherichia coli IAI39 hypothetical protein YP_002406054.1 5568 R 585057 CDS YP_002406055.1 218698426 7153191 complement(6414..7844) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino acid sodium/proton transporter 7844 yaaJ 7153191 yaaJ Escherichia coli IAI39 putative amino acid sodium/proton transporter YP_002406055.1 6414 R 585057 CDS YP_002406056.1 218698427 7153194 8123..9076 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8332529, 92334977, 11298760, 7592346, 8805555, 9007983, 9298646; Product type e : enzyme; transaldolase B 9076 talB 7153194 talB Escherichia coli IAI39 transaldolase B YP_002406056.1 8123 D 585057 CDS YP_002406057.1 218698428 7152939 9191..9778 1 NC_011750.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 9778 mogA 7152939 mogA Escherichia coli IAI39 molybdenum cofactor biosynthesis protein MogA YP_002406057.1 9191 D 585057 CDS YP_002406058.1 218698429 7152110 complement(9813..10379) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 10379 yaaH 7152110 yaaH Escherichia coli IAI39 hypothetical protein YP_002406058.1 9813 R 585057 CDS YP_002406059.1 218698430 7153192 complement(10528..11241) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8478327; Product type r : regulator; hypothetical protein 11241 htpY 7153192 htpY Escherichia coli IAI39 hypothetical protein YP_002406059.1 10528 R 585057 CDS YP_002406060.1 218698431 7151688 complement(11267..11671) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 11671 yaaI 7151688 yaaI Escherichia coli IAI39 hypothetical protein YP_002406060.1 11267 R 585057 CDS YP_002406061.1 218698432 7153193 12047..13963 1 NC_011750.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 13963 dnaK 7153193 dnaK Escherichia coli IAI39 molecular chaperone DnaK YP_002406061.1 12047 D 585057 CDS YP_002406062.1 218698433 7153014 14052..15182 1 NC_011750.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 15182 dnaJ 7153014 dnaJ Escherichia coli IAI39 chaperone protein DnaJ YP_002406062.1 14052 D 585057 CDS YP_002406063.1 218698434 7152875 16050..16811 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 16811 7152875 ECIAI39_0015 Escherichia coli IAI39 hypothetical protein YP_002406063.1 16050 D 585057 CDS YP_002406064.1 218698435 7149503 16795..18324 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Cerebroside-sulfatase 18324 7149503 ECIAI39_0016 Escherichia coli IAI39 putative Cerebroside-sulfatase YP_002406064.1 16795 D 585057 CDS YP_002406065.1 218698436 7149504 18418..19698 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 19698 7149504 ECIAI39_0017 Escherichia coli IAI39 hypothetical protein YP_002406065.1 18418 D 585057 CDS YP_002406066.1 218698437 7149505 19950..21116 1 NC_011750.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 21116 nhaA 7149505 nhaA Escherichia coli IAI39 pH-dependent sodium/proton antiporter YP_002406066.1 19950 D 585057 CDS YP_002406067.1 218698438 7152220 21176..22081 1 NC_011750.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 22081 nhaR 7152220 nhaR Escherichia coli IAI39 transcriptional activator NhaR YP_002406067.1 21176 D 585057 CDS YP_002406068.1 218698439 7152222 complement(22119..23078) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 23078 7152222 ECIAI39_0020 Escherichia coli IAI39 hypothetical protein YP_002406068.1 22119 R 585057 CDS YP_002406069.1 218698440 7149506 complement(23091..25541) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative fimbrial biogenesis outer membrane usher protein 25541 7149506 ECIAI39_0021 Escherichia coli IAI39 putative fimbrial biogenesis outer membrane usher protein YP_002406069.1 23091 R 585057 CDS YP_002406070.1 218698441 7149507 complement(25554..26237) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative membrane-associated pilin chaperone 26237 7149507 ECIAI39_0022 Escherichia coli IAI39 putative membrane-associated pilin chaperone YP_002406070.1 25554 R 585057 CDS YP_002406071.1 218698442 7149508 complement(26287..26820) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like protein 26820 7149508 ECIAI39_0023 Escherichia coli IAI39 putative fimbrial-like protein YP_002406071.1 26287 R 585057 CDS YP_002406072.1 218698443 7149509 complement(27121..28542) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 28542 7149509 ECIAI39_0024 Escherichia coli IAI39 hypothetical protein YP_002406072.1 27121 R 585057 CDS YP_002406073.1 218698444 7149510 complement(29026..29289) 1 NC_011750.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 29289 rpsT 7149510 rpsT Escherichia coli IAI39 30S ribosomal protein S20 YP_002406073.1 29026 R 585057 CDS YP_002406074.1 218698445 7152732 29618..30559 1 NC_011750.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 30559 ribF 7152732 ribF Escherichia coli IAI39 bifunctional riboflavin kinase/FMN adenylyltransferase YP_002406074.1 29618 D 585057 CDS YP_002406075.1 218698446 7152630 30602..33418 1 NC_011750.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 33418 ileS 7152630 ileS Escherichia coli IAI39 isoleucyl-tRNA synthetase YP_002406075.1 30602 D 585057 CDS YP_002406076.1 218698447 7151762 33418..33912 1 NC_011750.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 33912 lspA 7151762 lspA Escherichia coli IAI39 lipoprotein signal peptidase YP_002406076.1 33418 D 585057 CDS YP_002406077.1 218698448 7151975 34000..34449 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97332650, 2011499; Product type e : enzyme; FKBP-type peptidyl-prolyl cis-trans isomerase 34449 fkpB 7151975 fkpB Escherichia coli IAI39 FKBP-type peptidyl-prolyl cis-trans isomerase YP_002406077.1 34000 D 585057 CDS YP_002406078.1 218698449 7151346 34451..35401 1 NC_011750.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 35401 ispH 7151346 ispH Escherichia coli IAI39 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_002406078.1 34451 D 585057 CDS YP_002406079.1 218698450 7151857 35467..36381 1 NC_011750.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 36381 rihC 7151857 rihC Escherichia coli IAI39 ribonucleoside hydrolase RihC YP_002406079.1 35467 D 585057 CDS YP_002406080.1 218698451 7152633 36548..37369 1 NC_011750.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 37369 dapB 7152633 dapB Escherichia coli IAI39 dihydrodipicolinate reductase YP_002406080.1 36548 D 585057 CDS YP_002406081.1 218698452 7151085 37825..38973 1 NC_011750.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 38973 carA 7151085 carA Escherichia coli IAI39 carbamoyl phosphate synthase small subunit YP_002406081.1 37825 D 585057 CDS YP_002406082.1 218698453 7150902 38991..42212 1 NC_011750.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 42212 carB 7150902 carB Escherichia coli IAI39 carbamoyl phosphate synthase large subunit YP_002406082.1 38991 D 585057 CDS YP_002406083.1 218698454 7150903 42473..42868 1 NC_011750.1 regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; DNA-binding transcriptional activator CaiF 42868 caiF 7150903 caiF Escherichia coli IAI39 DNA-binding transcriptional activator CaiF YP_002406083.1 42473 D 585057 CDS YP_002406084.1 218698455 7150899 complement(42987..43577) 1 NC_011750.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE 43577 caiE 7150899 caiE Escherichia coli IAI39 carnitine operon protein CaiE YP_002406084.1 42987 R 585057 CDS YP_002406085.2 229598878 7150898 complement(43583..44368) 1 NC_011750.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase 44368 caiD 7150898 caiD Escherichia coli IAI39 carnitinyl-CoA dehydratase YP_002406085.2 43583 R 585057 CDS YP_002406086.1 218698457 7150897 complement(44477..46045) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15731894, 97189569, 7815937; Product type e : enzyme; putative crotonobetaine/carnitine-CoA ligase 46045 caiC 7150897 caiC Escherichia coli IAI39 putative crotonobetaine/carnitine-CoA ligase YP_002406086.1 44477 R 585057 CDS YP_002406087.1 218698458 7150896 complement(46103..47320) 1 NC_011750.1 catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine; crotonobetainyl-CoA:carnitine CoA-transferase 47320 caiB 7150896 caiB Escherichia coli IAI39 crotonobetainyl-CoA:carnitine CoA-transferase YP_002406087.1 46103 R 585057 CDS YP_002406088.1 218698459 7150895 complement(47449..48591) 1 NC_011750.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase 48591 caiA 7150895 caiA Escherichia coli IAI39 crotonobetainyl-CoA dehydrogenase YP_002406088.1 47449 R 585057 CDS YP_002406089.1 218698460 7150894 complement(48622..50136) 1 NC_011750.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter 50136 caiT 7150894 caiT Escherichia coli IAI39 L-carnitine/gamma-butyrobetaine antiporter YP_002406089.1 48622 R 585057 CDS YP_002406090.1 218698461 7150900 50609..51379 1 NC_011750.1 required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; putative electron transfer flavoprotein FixA 51379 fixA 7150900 fixA Escherichia coli IAI39 putative electron transfer flavoprotein FixA YP_002406090.1 50609 D 585057 CDS YP_002406091.1 218698462 7151340 51394..52335 1 NC_011750.1 involved in electron transfer during carnitine metabolism; putative electron transfer flavoprotein FixB 52335 fixB 7151340 fixB Escherichia coli IAI39 putative electron transfer flavoprotein FixB YP_002406091.1 51394 D 585057 CDS YP_002406092.1 218698463 7151341 52386..53672 1 NC_011750.1 FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; putative oxidoreductase 53672 fixC 7151341 fixC Escherichia coli IAI39 putative oxidoreductase YP_002406092.1 52386 D 585057 CDS YP_002406093.1 218698464 7151342 53669..53956 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96066354, 12081978; Product type pc : putative carrier; putative 4Fe-4S ferredoxin 53956 fixX 7151342 fixX Escherichia coli IAI39 putative 4Fe-4S ferredoxin YP_002406093.1 53669 D 585057 CDS YP_002406094.1 218698465 7151343 54014..55345 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 55345 yaaU 7151343 yaaU Escherichia coli IAI39 putative transporter YP_002406094.1 54014 D 585057 CDS YP_002406095.1 218698466 7153195 55453..55983 1 NC_011750.1 Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 55983 kefF 7153195 kefF Escherichia coli IAI39 glutathione-regulated potassium-efflux system ancillary protein KefF YP_002406095.1 55453 D 585057 CDS YP_002406096.1 218698467 7151896 55976..57838 1 NC_011750.1 transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 57838 kefC 7151896 kefC Escherichia coli IAI39 glutathione-regulated potassium-efflux system protein KefC YP_002406096.1 55976 D 585057 CDS YP_002406097.1 218698468 7151895 58030..58509 1 NC_011750.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 58509 folA 7151895 folA Escherichia coli IAI39 dihydrofolate reductase YP_002406097.1 58030 D 585057 CDS YP_002406098.1 218698469 7151397 58595..58828 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative antitoxin of gyrase inhibiting toxin-antitoxin system 58828 7151397 ECIAI39_0050 Escherichia coli IAI39 putative antitoxin of gyrase inhibiting toxin-antitoxin system YP_002406098.1 58595 D 585057 CDS YP_002406099.1 218698470 7149511 58831..59145 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative toxin of gyrase inhibiting toxin-antitoxin system 59145 7149511 ECIAI39_0051 Escherichia coli IAI39 putative toxin of gyrase inhibiting toxin-antitoxin system YP_002406099.1 58831 D 585057 CDS YP_002406100.1 218698471 7149512 complement(59142..59990) 1 NC_011750.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 59990 apaH 7149512 apaH Escherichia coli IAI39 diadenosine tetraphosphatase YP_002406100.1 59142 R 585057 CDS YP_002406101.1 218698472 7150740 complement(59997..60374) 1 NC_011750.1 protein associated with Co2+ and Mg2+ efflux; ApaG protein 60374 apaG 7150740 apaG Escherichia coli IAI39 ApaG protein YP_002406101.1 59997 R 585057 CDS YP_002406102.1 218698473 7150739 complement(60377..61198) 1 NC_011750.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 61198 ksgA 7150739 ksgA Escherichia coli IAI39 dimethyladenosine transferase YP_002406102.1 60377 R 585057 CDS YP_002406103.1 218698474 7151910 complement(61195..62184) 1 NC_011750.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase 62184 pdxA 7151910 pdxA Escherichia coli IAI39 4-hydroxythreonine-4-phosphate dehydrogenase YP_002406103.1 61195 R 585057 CDS YP_002406104.1 218698475 7152355 complement(62184..63470) 1 NC_011750.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA 63470 surA 7152355 surA Escherichia coli IAI39 peptidyl-prolyl cis-trans isomerase SurA YP_002406104.1 62184 R 585057 CDS YP_002406105.1 218698476 7152932 complement(63523..65877) 1 NC_011750.1 determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein 65877 imp 7152932 imp Escherichia coli IAI39 organic solvent tolerance protein YP_002406105.1 63523 R 585057 CDS YP_002406106.1 218698477 7151775 66132..66947 1 NC_011750.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 66947 djlA 7151775 djlA Escherichia coli IAI39 Dna-J like membrane chaperone protein YP_002406106.1 66132 D 585057 CDS YP_002406107.1 218698478 7151144 67021..67551 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 67551 7151144 ECIAI39_0059 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002406107.1 67021 D 585057 CDS YP_002406108.1 218698479 7149513 67656..68378 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 68378 7149513 ECIAI39_0060 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002406108.1 67656 D 585057 CDS YP_002406109.1 218698480 7149514 complement(68500..69159) 1 NC_011750.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A 69159 rluA 7149514 rluA Escherichia coli IAI39 23S rRNA/tRNA pseudouridine synthase A YP_002406109.1 68500 R 585057 CDS YP_002406110.1 218698481 7152641 complement(69171..72077) 1 NC_011750.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA 72077 hepA 7152641 hepA Escherichia coli IAI39 ATP-dependent helicase HepA YP_002406110.1 69171 R 585057 CDS YP_002406111.1 218698482 7151636 complement(72241..74592) 1 NC_011750.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II 74592 polB 7151636 polB Escherichia coli IAI39 DNA polymerase II YP_002406111.1 72241 R 585057 CDS YP_002406112.1 218698483 7152440 complement(74667..75362) 1 NC_011750.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 75362 araD 7152440 araD Escherichia coli IAI39 L-ribulose-5-phosphate 4-epimerase YP_002406112.1 74667 R 585057 CDS YP_002406113.1 218698484 7150750 complement(75477..76979) 1 NC_011750.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase 76979 araA 7150750 araA Escherichia coli IAI39 L-arabinose isomerase YP_002406113.1 75477 R 585057 CDS YP_002406114.1 218698485 7150747 complement(76990..78690) 1 NC_011750.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase 78690 araB 7150747 araB Escherichia coli IAI39 ribulokinase YP_002406114.1 76990 R 585057 CDS YP_002406115.1 218698486 7150748 78978..79874 1 NC_011750.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; DNA-binding transcriptional regulator AraC 79874 araC 7150748 araC Escherichia coli IAI39 DNA-binding transcriptional regulator AraC YP_002406115.1 78978 D 585057 CDS YP_002406116.1 218698487 7150749 80385..81236 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 81236 7150749 ECIAI39_0068 Escherichia coli IAI39 hypothetical protein YP_002406116.1 80385 D 585057 CDS YP_002406117.1 218698488 7149515 81243..81665 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 81665 7149515 ECIAI39_0069 Escherichia coli IAI39 hypothetical protein YP_002406117.1 81243 D 585057 CDS YP_002406118.1 218698489 7149516 81820..82584 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 82584 yabI 7149516 yabI Escherichia coli IAI39 hypothetical protein YP_002406118.1 81820 D 585057 CDS YP_002406119.1 218698490 7153197 complement(82666..83364) 1 NC_011750.1 with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding subunit 83364 thiQ 7153197 thiQ Escherichia coli IAI39 thiamine transporter ATP-binding subunit YP_002406119.1 82666 R 585057 CDS YP_002406120.1 218698491 7152975 complement(83348..84958) 1 NC_011750.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein 84958 thiP 7152975 thiP Escherichia coli IAI39 thiamine transporter membrane protein YP_002406120.1 83348 R 585057 CDS YP_002406121.1 218698492 7152974 complement(84934..85917) 1 NC_011750.1 part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit 85917 tbpA 7152974 tbpA Escherichia coli IAI39 thiamine transporter substrate binding subunit YP_002406121.1 84934 R 585057 CDS YP_002406122.1 218698493 7150531 86288..86857 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 86857 7150531 ECIAI39_0074 Escherichia coli IAI39 hypothetical protein YP_002406122.1 86288 D 585057 CDS YP_002406123.1 218698494 7149517 complement(87087..88766) 1 NC_011750.1 activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR 88766 sgrR 7149517 sgrR Escherichia coli IAI39 transcriptional regulator SgrR YP_002406123.1 87087 R 585057 CDS YP_002406124.1 218698495 7152848 complement(89073..89678) 1 NC_011750.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 89678 leuD 7152848 leuD Escherichia coli IAI39 isopropylmalate isomerase small subunit YP_002406124.1 89073 R 585057 CDS YP_002406125.1 218698496 7151927 complement(89689..91089) 1 NC_011750.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 91089 leuC 7151927 leuC Escherichia coli IAI39 isopropylmalate isomerase large subunit YP_002406125.1 89689 R 585057 CDS YP_002406126.1 218698497 7151926 complement(91092..92183) 1 NC_011750.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 92183 leuB 7151926 leuB Escherichia coli IAI39 3-isopropylmalate dehydrogenase YP_002406126.1 91092 R 585057 CDS YP_002406127.1 218698498 7151925 complement(92183..93754) 1 NC_011750.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 93754 leuA 7151925 leuA Escherichia coli IAI39 2-isopropylmalate synthase YP_002406127.1 92183 R 585057 CDS YP_002406128.1 218698499 7150539 complement(93847..93933) 1 NC_011750.1 involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide 93933 leuL 7150539 leuL Escherichia coli IAI39 leu operon leader peptide YP_002406128.1 93847 R 585057 CDS YP_002406129.1 218698500 7151928 94592..95536 1 NC_011750.1 activator for leuABCD operon; member of LysR family of transcriptional activators; leucine transcriptional activator 95536 leuO 7151928 leuO Escherichia coli IAI39 leucine transcriptional activator YP_002406129.1 94592 D 585057 CDS YP_002406130.1 218698501 7151929 95852..97576 1 NC_011750.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 97576 ilvI 7151929 ilvI Escherichia coli IAI39 acetolactate synthase 3 catalytic subunit YP_002406130.1 95852 D 585057 CDS YP_002406131.1 218698502 7151770 97579..98070 1 NC_011750.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 98070 ilvH 7151770 ilvH Escherichia coli IAI39 acetolactate synthase 3 regulatory subunit YP_002406131.1 97579 D 585057 CDS YP_002406132.1 218698503 7151769 98250..99254 1 NC_011750.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 99254 fruR 7151769 fruR Escherichia coli IAI39 DNA-binding transcriptional regulator FruR YP_002406132.1 98250 D 585057 CDS YP_002406133.1 218698504 7151422 99856..100314 1 NC_011750.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 100314 mraZ 7151422 mraZ Escherichia coli IAI39 cell division protein MraZ YP_002406133.1 99856 D 585057 CDS YP_002406134.1 218698505 7152121 100316..101257 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20042184, 10493123, 2187182, 6350821; Product type e : enzyme; S-adenosyl-methyltransferase MraW 101257 mraW 7152121 mraW Escherichia coli IAI39 S-adenosyl-methyltransferase MraW YP_002406134.1 100316 D 585057 CDS YP_002406135.1 218698506 7152119 101254..101619 1 NC_011750.1 membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 101619 ftsL 7152119 ftsL Escherichia coli IAI39 cell division protein FtsL YP_002406135.1 101254 D 585057 CDS YP_002406136.1 218698507 7151439 101635..103401 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91072213, 92202178, 94095121, 9603865, 9614966, 1332942, 1447153, 2198024, 2677607, 2681146, 3049550, 3911028, 6350821; Product type e : enzyme; transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3) 103401 ftsI 7151439 ftsI Escherichia coli IAI39 transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3) YP_002406136.1 101635 D 585057 CDS YP_002406137.1 218698508 7151437 103388..104875 1 NC_011750.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 104875 murE 7151437 murE Escherichia coli IAI39 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_002406137.1 103388 D 585057 CDS YP_002406138.1 218698509 7152149 104872..106230 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88273095, 90248455, 91310568, 97128642, 11090285, 2668880, 9166795; Product type e : enzyme; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 106230 murF 7152149 murF Escherichia coli IAI39 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase YP_002406138.1 104872 D 585057 CDS YP_002406139.1 218698510 7152150 106224..107306 1 NC_011750.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 107306 mraY 7152150 mraY Escherichia coli IAI39 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_002406139.1 106224 D 585057 CDS YP_002406140.1 218698511 7152120 107309..108625 1 NC_011750.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 108625 murD 7152120 murD Escherichia coli IAI39 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_002406140.1 107309 D 585057 CDS YP_002406141.1 218698512 7152148 108625..109869 1 NC_011750.1 integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 109869 ftsW 7152148 ftsW Escherichia coli IAI39 cell division protein FtsW YP_002406141.1 108625 D 585057 CDS YP_002406142.1 218698513 7151442 109866..110933 1 NC_011750.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 110933 murG 7151442 murG Escherichia coli IAI39 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_002406142.1 109866 D 585057 CDS YP_002406143.1 218698514 7152151 110987..112462 1 NC_011750.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 112462 murC 7152151 murC Escherichia coli IAI39 UDP-N-acetylmuramate--L-alanine ligase YP_002406143.1 110987 D 585057 CDS YP_002406144.1 218698515 7152147 112455..113375 1 NC_011750.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 113375 ddl 7152147 ddl Escherichia coli IAI39 D-alanine--D-alanine ligase YP_002406144.1 112455 D 585057 CDS YP_002406145.1 218698516 7151103 113377..114207 1 NC_011750.1 involved in septum formation; cell division protein FtsQ 114207 ftsQ 7151103 ftsQ Escherichia coli IAI39 cell division protein FtsQ YP_002406145.1 113377 D 585057 CDS YP_002406146.1 218698517 7151441 114204..115466 1 NC_011750.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 115466 ftsA 7151441 ftsA Escherichia coli IAI39 cell division protein FtsA YP_002406146.1 114204 D 585057 CDS YP_002406147.1 218698518 7151433 115528..116679 1 NC_011750.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 116679 ftsZ 7151433 ftsZ Escherichia coli IAI39 cell division protein FtsZ YP_002406147.1 115528 D 585057 CDS YP_002406148.1 218698519 7151445 116780..117697 1 NC_011750.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 117697 lpxC 7151445 lpxC Escherichia coli IAI39 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_002406148.1 116780 D 585057 CDS YP_002406149.1 218698520 7151967 117928..118440 1 NC_011750.1 secM translational pause allows for the initiation of secA translation; SecA regulator SecM 118440 secM 7151967 secM Escherichia coli IAI39 SecA regulator SecM YP_002406149.1 117928 D 585057 CDS YP_002406150.1 218698521 7152824 118502..121207 1 NC_011750.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 121207 secA 7152824 secA Escherichia coli IAI39 preprotein translocase subunit SecA YP_002406150.1 118502 D 585057 CDS YP_002406151.1 218698522 7152818 121267..121665 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10218109, 89264540, 90136514, 91225007, 97444511, 1309939, 2841285, 3033442, 3288626, 7578113, 9063868; Product type e : enzyme; nucleoside triphosphate pyrophosphohydrolase 121665 mutT 7152818 mutT Escherichia coli IAI39 nucleoside triphosphate pyrophosphohydrolase YP_002406151.1 121267 D 585057 CDS YP_002406152.1 218698523 7152159 complement(121960..122703) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 122703 yacF 7152159 yacF Escherichia coli IAI39 hypothetical protein YP_002406152.1 121960 R 585057 CDS YP_002406153.1 218698524 7153199 complement(122703..123323) 1 NC_011750.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 123323 coaE 7153199 coaE Escherichia coli IAI39 dephospho-CoA kinase YP_002406153.1 122703 R 585057 CDS YP_002406154.1 218698525 7150975 123548..124591 1 NC_011750.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 124591 guaC 7150975 guaC Escherichia coli IAI39 guanosine 5'-monophosphate oxidoreductase YP_002406154.1 123548 D 585057 CDS YP_002406155.1 218698526 7151598 complement(124626..125828) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96099298, 2904262, 7959070; Product type s : structure; type IV pilin biogenesis protein 125828 hofC 7151598 hofC Escherichia coli IAI39 type IV pilin biogenesis protein YP_002406155.1 124626 R 585057 CDS YP_002406156.1 218698527 7151665 complement(125818..127203) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96099298, 7959070; Product type pt : putative transporter; hypothetical protein 127203 hofB 7151665 hofB Escherichia coli IAI39 hypothetical protein YP_002406156.1 125818 R 585057 CDS YP_002406157.1 218698528 7151664 complement(127213..127653) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20100782, 20271862, 96099298, 7959070; Product type ps : putative structure; putative major pilin subunit 127653 ppdD 7151664 ppdD Escherichia coli IAI39 putative major pilin subunit YP_002406157.1 127213 R 585057 CDS YP_002406158.1 218698529 7152457 complement(127856..128749) 1 NC_011750.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase 128749 nadC 7152457 nadC Escherichia coli IAI39 quinolinate phosphoribosyltransferase YP_002406158.1 127856 R 585057 CDS YP_002406159.1 218698530 7152167 128837..129388 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90113890, 95047240, 2607970, 7959070; Product type e : enzyme; N-acetyl-anhydromuranmyl-L-alanine amidase 129388 ampD 7152167 ampD Escherichia coli IAI39 N-acetyl-anhydromuranmyl-L-alanine amidase YP_002406159.1 128837 D 585057 CDS YP_002406160.1 218698531 7150730 129385..130239 1 NC_011750.1 involved in regulation of beta-lactamase; putative signaling protein; regulatory protein AmpE 130239 ampE 7150730 ampE Escherichia coli IAI39 regulatory protein AmpE YP_002406160.1 129385 D 585057 CDS YP_002406161.1 218698532 7150731 complement(130282..131655) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1104763, 90174991, 9150230; Product type t : transporter; aromatic amino acid transporter 131655 aroP 7150731 aroP Escherichia coli IAI39 aromatic amino acid transporter YP_002406161.1 130282 R 585057 CDS YP_002406162.1 218698533 7150786 132196..132960 1 NC_011750.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 132960 pdhR 7150786 pdhR Escherichia coli IAI39 transcriptional regulator PdhR YP_002406162.1 132196 D 585057 CDS YP_002406163.1 218698534 7153012 133121..135784 1 NC_011750.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 135784 aceE 7153012 aceE Escherichia coli IAI39 pyruvate dehydrogenase subunit E1 YP_002406163.1 133121 D 585057 CDS YP_002406164.1 218698535 7150662 135799..137691 1 NC_011750.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 137691 aceF 7150662 aceF Escherichia coli IAI39 dihydrolipoamide acetyltransferase YP_002406164.1 135799 D 585057 CDS YP_002406165.1 218698536 7150663 137899..139323 1 NC_011750.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 139323 lpd 7150663 lpd Escherichia coli IAI39 dihydrolipoamide dehydrogenase YP_002406165.1 137899 D 585057 CDS YP_002406166.1 218698537 7151957 complement(139394..141247) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 141247 yacH 7151957 yacH Escherichia coli IAI39 hypothetical protein YP_002406166.1 139394 R 585057 CDS YP_002406167.1 218698538 7153200 141602..144199 1 NC_011750.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 144199 acnB 7153200 acnB Escherichia coli IAI39 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase YP_002406167.1 141602 D 585057 CDS YP_002406168.1 218698539 7150667 144374..144736 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2666401, 7567469; hypothetical protein 144736 yacL 7150667 yacL Escherichia coli IAI39 hypothetical protein YP_002406168.1 144374 D 585057 CDS YP_002406169.1 218698540 7153201 complement(144774..145568) 1 NC_011750.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase 145568 speD 7153201 speD Escherichia coli IAI39 S-adenosylmethionine decarboxylase YP_002406169.1 144774 R 585057 CDS YP_002406170.1 218698541 7152882 complement(145584..146450) 1 NC_011750.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 146450 speE 7152882 speE Escherichia coli IAI39 spermidine synthase YP_002406170.1 145584 R 585057 CDS YP_002406171.1 218698542 7152883 complement(146556..147074) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2666401; hypothetical protein 147074 yacC 7152883 yacC Escherichia coli IAI39 hypothetical protein YP_002406171.1 146556 R 585057 CDS YP_002406172.1 218698543 7153198 147069..148619 1 NC_011750.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 148619 cueO 7153198 cueO Escherichia coli IAI39 multicopper oxidase YP_002406172.1 147069 D 585057 CDS YP_002406173.1 218698544 7151026 complement(148666..151056) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10359647, 11604400, 14612441, 91035240, 93123180, 93286127; Product type e : enzyme; glucose dehydrogenase 151056 gcd 7151026 gcd Escherichia coli IAI39 glucose dehydrogenase YP_002406173.1 148666 R 585057 CDS YP_002406174.1 218698545 7151493 151262..151798 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 13808016, 339828, 6787390, 6801015, 12070315; Product type e : enzyme; hypoxanthine phosphoribosyltransferase 151798 hpt 7151493 hpt Escherichia coli IAI39 hypoxanthine phosphoribosyltransferase YP_002406174.1 151262 D 585057 CDS YP_002406175.1 218698546 7151672 complement(151839..152501) 1 NC_011750.1 catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase 152501 can 7151672 can Escherichia coli IAI39 carbonic anhydrase YP_002406175.1 151839 R 585057 CDS YP_002406176.1 218698547 7150901 152610..153536 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 153536 yadG 7150901 yadG Escherichia coli IAI39 putative ABC transporter ATP-binding protein YP_002406176.1 152610 D 585057 CDS YP_002406177.1 218698548 7153207 153533..154303 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10474187; Product type pt : putative transporter; putative ABC transporter membrane protein 154303 yadH 7153207 yadH Escherichia coli IAI39 putative ABC transporter membrane protein YP_002406177.1 153533 D 585057 CDS YP_002406178.1 218698549 7153208 154408..154848 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative PTS Enzyme IIA 154848 yadI 7153208 yadI Escherichia coli IAI39 putative PTS Enzyme IIA YP_002406178.1 154408 D 585057 CDS YP_002406179.1 218698550 7153209 154912..156141 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported polysaccharide deacetylase 156141 yadE 7153209 yadE Escherichia coli IAI39 putative exported polysaccharide deacetylase YP_002406179.1 154912 D 585057 CDS YP_002406180.1 218698551 7153206 complement(156145..156525) 1 NC_011750.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 156525 panD 7153206 panD Escherichia coli IAI39 aspartate alpha-decarboxylase YP_002406180.1 156145 R 585057 CDS YP_002406181.1 218698552 7152325 156799..157731 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11319082; Product type pe : putative enzyme; putative transposase 157731 yadD 7152325 yadD Escherichia coli IAI39 putative transposase YP_002406181.1 156799 D 585057 CDS YP_002406182.1 218698553 7153205 complement(158091..158942) 1 NC_011750.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 158942 panC 7153205 panC Escherichia coli IAI39 pantoate--beta-alanine ligase YP_002406182.1 158091 R 585057 CDS YP_002406183.1 218698554 7152324 complement(158954..159748) 1 NC_011750.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 159748 panB 7152324 panB Escherichia coli IAI39 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_002406183.1 158954 R 585057 CDS YP_002406184.1 218698555 7153203 160377..160703 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 160703 7153203 ECIAI39_0137 Escherichia coli IAI39 transposase ORF A, IS629 YP_002406184.1 160377 D 585057 CDS YP_002406185.1 218698556 7149518 160700..161590 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 161590 7149518 ECIAI39_0138 Escherichia coli IAI39 transposase ORF B, IS629 YP_002406185.1 160700 D 585057 CDS YP_002406186.1 218698557 7153204 complement(162479..163075) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein 163075 yadK 7153204 yadK Escherichia coli IAI39 putative fimbrial-like adhesin protein YP_002406186.1 162479 R 585057 CDS YP_002406187.1 218698558 7153210 complement(163102..163707) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein 163707 yadL 7153210 yadL Escherichia coli IAI39 putative fimbrial-like adhesin protein YP_002406187.1 163102 R 585057 CDS YP_002406188.1 218698559 7153211 complement(163719..164261) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein 164261 yadM 7153211 yadM Escherichia coli IAI39 putative fimbrial-like adhesin exported protein YP_002406188.1 163719 R 585057 CDS YP_002406189.1 218698560 7153212 complement(164408..166903) 1 NC_011750.1 similar to the fimbrial usher protein PapC; putative outer membrane usher protein 166903 htrE 7153212 htrE Escherichia coli IAI39 putative outer membrane usher protein YP_002406189.1 164408 R 585057 CDS YP_002406190.1 218698561 7151689 complement(166938..167678) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 93352405, 8102362, 15561151; Product type f : factor; putative chaperone protein EcpD 167678 ecpD 7151689 ecpD Escherichia coli IAI39 putative chaperone protein EcpD YP_002406190.1 166938 R 585057 CDS YP_002406191.1 218698562 7151201 complement(167783..168367) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein 168367 yadN 7151201 yadN Escherichia coli IAI39 putative fimbrial-like adhesin exported protein YP_002406191.1 167783 R 585057 CDS YP_002406192.1 218698563 7153213 complement(168738..169217) 1 NC_011750.1 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase 169217 folK 7153213 folK Escherichia coli IAI39 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase YP_002406192.1 168738 R 585057 CDS YP_002406193.1 218698564 7151402 complement(169214..170632) 1 NC_011750.1 Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase I 170632 pcnB 7151402 pcnB Escherichia coli IAI39 poly(A) polymerase I YP_002406193.1 169214 R 585057 CDS YP_002406194.1 218698565 7152353 complement(170671..171597) 1 NC_011750.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase 171597 yadB 7152353 yadB Escherichia coli IAI39 glutamyl-Q tRNA(Asp) synthetase YP_002406194.1 170671 R 585057 CDS YP_002406195.1 218698566 7153202 complement(171634..172089) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15294157, 90202727, 2013578, 9298646, 9600841; Product type r : regulator; RNA polymerase-binding transcription factor 172089 dksA 7153202 dksA Escherichia coli IAI39 RNA polymerase-binding transcription factor YP_002406195.1 171634 R 585057 CDS YP_002406196.1 218698567 7151147 complement(172267..172971) 1 NC_011750.1 Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A 172971 sfsA 7151147 sfsA Escherichia coli IAI39 sugar fermentation stimulation protein A YP_002406196.1 172267 R 585057 CDS YP_002406197.1 218698568 7152842 complement(172986..173516) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97094878; Product type e : enzyme; 2'-5' RNA ligase 173516 ligT 7152842 ligT Escherichia coli IAI39 2'-5' RNA ligase YP_002406197.1 172986 R 585057 CDS YP_002406198.1 218698569 7151937 173590..176019 1 NC_011750.1 similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 176019 hrpB 7151937 hrpB Escherichia coli IAI39 ATP-dependent RNA helicase HrpB YP_002406198.1 173590 D 585057 CDS YP_002406199.1 218698570 7151674 176113..178647 1 NC_011750.1 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 178647 mrcB 7151674 mrcB Escherichia coli IAI39 penicillin-binding protein 1b YP_002406199.1 176113 D 585057 CDS YP_002406200.1 218698571 7152123 178867..181116 1 NC_011750.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 181116 fhuA 7152123 fhuA Escherichia coli IAI39 ferrichrome outer membrane transporter YP_002406200.1 178867 D 585057 CDS YP_002406201.1 218698572 7151314 181167..181964 1 NC_011750.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding subunit 181964 fhuC 7151314 fhuC Escherichia coli IAI39 iron-hydroxamate transporter ATP-binding subunit YP_002406201.1 181167 D 585057 CDS YP_002406202.1 218698573 7151316 181964..182854 1 NC_011750.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 182854 fhuD 7151316 fhuD Escherichia coli IAI39 iron-hydroxamate transporter substrate-binding subunit YP_002406202.1 181964 D 585057 CDS YP_002406203.1 218698574 7151317 182851..184833 1 NC_011750.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 184833 fhuB 7151317 fhuB Escherichia coli IAI39 iron-hydroxamate transporter permease subunit YP_002406203.1 182851 D 585057 CDS YP_002406204.1 218698575 7151315 complement(184868..186148) 1 NC_011750.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 186148 hemL 7151315 hemL Escherichia coli IAI39 glutamate-1-semialdehyde aminotransferase YP_002406204.1 184868 R 585057 CDS YP_002406205.1 218698576 7151632 186373..187794 1 NC_011750.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 187794 clcA 7151632 clcA Escherichia coli IAI39 chloride channel protein YP_002406205.1 186373 D 585057 CDS YP_002406206.1 218698577 7150960 187876..188220 1 NC_011750.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 188220 yadR 7150960 yadR Escherichia coli IAI39 iron-sulfur cluster insertion protein ErpA YP_002406206.1 187876 D 585057 CDS YP_002406207.1 218698578 7153214 complement(188267..188890) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 188890 yadS 7153214 yadS Escherichia coli IAI39 hypothetical protein YP_002406207.1 188267 R 585057 CDS YP_002406208.1 218698579 7153215 complement(188928..189728) 1 NC_011750.1 solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF 189728 btuF 7153215 btuF Escherichia coli IAI39 vitamin B12-transporter protein BtuF YP_002406208.1 188928 R 585057 CDS YP_002406209.1 218698580 7150882 complement(189721..190419) 1 NC_011750.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 190419 pfs 7150882 pfs Escherichia coli IAI39 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_002406209.1 189721 R 585057 CDS YP_002406210.1 218698581 7152376 190503..192020 1 NC_011750.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 192020 dgt 7152376 dgt Escherichia coli IAI39 deoxyguanosinetriphosphate triphosphohydrolase YP_002406210.1 190503 D 585057 CDS YP_002406211.1 218698582 7151132 192150..193574 1 NC_011750.1 protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 193574 degP 7151132 degP Escherichia coli IAI39 serine endoprotease YP_002406211.1 192150 D 585057 CDS YP_002406212.1 218698583 7151114 193729..194886 1 NC_011750.1 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization; carbohydrate diacid transcriptional activator CdaR 194886 cdaR 7151114 cdaR Escherichia coli IAI39 carbohydrate diacid transcriptional activator CdaR YP_002406212.1 193729 D 585057 CDS YP_002406213.1 218698584 7150919 complement(194940..195326) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 195326 yaeH 7150919 yaeH Escherichia coli IAI39 hypothetical protein YP_002406213.1 194940 R 585057 CDS YP_002406214.1 218698585 7153218 complement(195641..196465) 1 NC_011750.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 196465 dapD 7153218 dapD Escherichia coli IAI39 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase YP_002406214.1 195641 R 585057 CDS YP_002406215.1 218698586 7151086 complement(196496..199168) 1 NC_011750.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase 199168 glnD 7151086 glnD Escherichia coli IAI39 PII uridylyl-transferase YP_002406215.1 196496 R 585057 CDS YP_002406216.1 218698587 7151525 complement(199230..200024) 1 NC_011750.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 200024 map 7151525 map Escherichia coli IAI39 methionine aminopeptidase YP_002406216.1 199230 R 585057 CDS YP_002406217.1 218698588 7152935 200392..201117 1 NC_011750.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 201117 rpsB 7152935 rpsB Escherichia coli IAI39 30S ribosomal protein S2 YP_002406217.1 200392 D 585057 CDS YP_002406218.1 218698589 7152714 201252..202103 1 NC_011750.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 202103 tsf 7152714 tsf Escherichia coli IAI39 elongation factor Ts YP_002406218.1 201252 D 585057 CDS YP_002406219.1 218698590 7153046 202250..202975 1 NC_011750.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 202975 pyrH 7153046 pyrH Escherichia coli IAI39 uridylate kinase YP_002406219.1 202250 D 585057 CDS YP_002406220.1 218698591 7152554 complement(202965..203243) 1 NC_011750.1 hypothetical protein 203243 7152554 ECIAI39_0174 Escherichia coli IAI39 hypothetical protein YP_002406220.1 202965 R 585057 CDS YP_002406221.1 218698592 7149520 203125..203682 1 NC_011750.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 203682 frr 7149520 frr Escherichia coli IAI39 ribosome recycling factor YP_002406221.1 203125 D 585057 CDS YP_002406222.1 218698593 7151417 203774..204970 1 NC_011750.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 204970 dxr 7151417 dxr Escherichia coli IAI39 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_002406222.1 203774 D 585057 CDS YP_002406223.1 218698594 7151189 205156..205917 1 NC_011750.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 205917 ispU 7151189 ispU Escherichia coli IAI39 undecaprenyl pyrophosphate synthase YP_002406223.1 205156 D 585057 CDS YP_002406224.1 218698595 7151858 205930..206787 1 NC_011750.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 206787 cdsA 7151858 cdsA Escherichia coli IAI39 CDP-diglyceride synthase YP_002406224.1 205930 D 585057 CDS YP_002406225.1 218698596 7150922 206799..208151 1 NC_011750.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 208151 yaeL 7150922 yaeL Escherichia coli IAI39 zinc metallopeptidase RseP YP_002406225.1 206799 D 585057 CDS YP_002406226.1 218698597 7153220 208181..210613 1 NC_011750.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 210613 yaeT 7153220 yaeT Escherichia coli IAI39 outer membrane protein assembly factor YaeT YP_002406226.1 208181 D 585057 CDS YP_002406227.1 218698598 7153224 210735..211220 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15101556, 90201355, 97032152, 99386928, 1987124, 2843433, 9298646, 2167239; Product type f : factor; periplasmic chaperone 211220 hlpA 7153224 hlpA Escherichia coli IAI39 periplasmic chaperone YP_002406227.1 210735 D 585057 CDS YP_002406228.1 218698599 7151660 211224..212249 1 NC_011750.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 212249 lpxD 7151660 lpxD Escherichia coli IAI39 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_002406228.1 211224 D 585057 CDS YP_002406229.1 218698600 7151968 212354..212809 1 NC_011750.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 212809 fabZ 7151968 fabZ Escherichia coli IAI39 (3R)-hydroxymyristoyl-ACP dehydratase YP_002406229.1 212354 D 585057 CDS YP_002406230.1 218698601 7151271 212813..213601 1 NC_011750.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 213601 lpxA 7151271 lpxA Escherichia coli IAI39 UDP-N-acetylglucosamine acyltransferase YP_002406230.1 212813 D 585057 CDS YP_002406231.1 218698602 7151965 213601..214749 1 NC_011750.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 214749 lpxB 7151965 lpxB Escherichia coli IAI39 lipid-A-disaccharide synthase YP_002406231.1 213601 D 585057 CDS YP_002406232.1 218698603 7151966 214746..215342 1 NC_011750.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 215342 rnhB 7151966 rnhB Escherichia coli IAI39 ribonuclease HII YP_002406232.1 214746 D 585057 CDS YP_002406233.1 218698604 7152659 215379..218861 1 NC_011750.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 218861 dnaE 7152659 dnaE Escherichia coli IAI39 DNA polymerase III subunit alpha YP_002406233.1 215379 D 585057 CDS YP_002406234.1 218698605 7151156 218874..219833 1 NC_011750.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 219833 accA 7151156 accA Escherichia coli IAI39 acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_002406234.1 218874 D 585057 CDS YP_002406235.1 218698606 7150656 219932..222073 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97480927, 98195734, 98357244, 9226257, 9723924; Product type e : enzyme; lysine decarboxylase 2 222073 ldcC 7150656 ldcC Escherichia coli IAI39 lysine decarboxylase 2 YP_002406235.1 219932 D 585057 CDS YP_002406236.1 218698607 7151918 222130..222519 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 222519 yaeR 7151918 yaeR Escherichia coli IAI39 hypothetical protein YP_002406236.1 222130 D 585057 CDS YP_002406237.1 218698608 7153223 222584..223882 1 NC_011750.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 223882 tilS 7153223 tilS Escherichia coli IAI39 tRNA(Ile)-lysidine synthetase YP_002406237.1 222584 D 585057 CDS YP_002406238.1 218698609 7152987 complement(223940..224662) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 224662 7152987 ECIAI39_0192 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002406238.1 223940 R 585057 CDS YP_002406239.1 218698610 7149521 complement(224767..225297) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 225297 7149521 ECIAI39_0193 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002406239.1 224767 R 585057 CDS YP_002406240.1 218698611 7149522 complement(225394..226698) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90155203, 95238302, 2051480; Product type e : enzyme; inosine/guanosine kinase 226698 gsk 7149522 gsk Escherichia coli IAI39 inosine/guanosine kinase YP_002406240.1 225394 R 585057 CDS YP_002406241.1 218698612 7151593 226850..227809 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9401025, 98244813, 2051480, 7721718; Product type e : enzyme; acetyl esterase 227809 aes 7151593 aes Escherichia coli IAI39 acetyl esterase YP_002406241.1 226850 D 585057 CDS YP_002406242.1 218698613 7150696 complement(227806..228768) 1 NC_011750.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 228768 hemH 7150696 hemH Escherichia coli IAI39 ferrochelatase YP_002406242.1 227806 R 585057 CDS YP_002406243.1 218698614 7151631 complement(228900..229544) 1 NC_011750.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 229544 adk 7151631 adk Escherichia coli IAI39 adenylate kinase YP_002406243.1 228900 R 585057 CDS YP_002406244.1 218698615 7150692 complement(229763..231637) 1 NC_011750.1 molecular chaperone; heat shock protein 90 231637 htpG 7150692 htpG Escherichia coli IAI39 heat shock protein 90 YP_002406244.1 229763 R 585057 CDS YP_002406245.1 218698616 7151686 complement(231747..232352) 1 NC_011750.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 232352 recR 7151686 recR Escherichia coli IAI39 recombination protein RecR YP_002406245.1 231747 R 585057 CDS YP_002406246.1 218698617 7152597 complement(232352..232681) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15322138, 1698765, 2674903; hypothetical protein 232681 ybaB 7152597 ybaB Escherichia coli IAI39 hypothetical protein YP_002406246.1 232352 R 585057 CDS YP_002406247.1 218698618 7153283 complement(232734..234665) 1 NC_011750.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 234665 dnaX 7153283 dnaX Escherichia coli IAI39 DNA polymerase III subunits gamma and tau YP_002406247.1 232734 R 585057 CDS YP_002406248.1 218698619 7151163 complement(234794..235345) 1 NC_011750.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 235345 apt 7151163 apt Escherichia coli IAI39 adenine phosphoribosyltransferase YP_002406248.1 234794 R 585057 CDS YP_002406249.1 218698620 7150745 complement(235498..235875) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 235875 ybaN 7150745 ybaN Escherichia coli IAI39 hypothetical protein YP_002406249.1 235498 R 585057 CDS YP_002406250.1 218698621 7153287 235945..236472 1 NC_011750.1 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' 236472 priC 7153287 priC Escherichia coli IAI39 primosomal replication protein N'' YP_002406250.1 235945 D 585057 CDS YP_002406251.1 218698622 7152477 236486..236647 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 236647 ybaM 7152477 ybaM Escherichia coli IAI39 hypothetical protein YP_002406251.1 236486 D 585057 CDS YP_002406252.1 218698623 7153286 complement(236859..240221) 1 NC_011750.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 240221 kefA 7153286 kefA Escherichia coli IAI39 potassium efflux protein KefA YP_002406252.1 236859 R 585057 CDS YP_002406253.1 218698624 7151892 complement(240349..240996) 1 NC_011750.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR 240996 acrR 7151892 acrR Escherichia coli IAI39 DNA-binding transcriptional repressor AcrR YP_002406253.1 240349 R 585057 CDS YP_002406254.1 218698625 7150679 241138..242331 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15155734, 21450803, 383699, 390095, 94012493, 10920254, 7651136; Product type t : transporter; multidrug efflux system 242331 acrA 7150679 acrA Escherichia coli IAI39 multidrug efflux system YP_002406254.1 241138 D 585057 CDS YP_002406255.1 218698626 7150673 complement(245034..245924) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 245924 7150673 ECIAI39_0210 Escherichia coli IAI39 transposase ORF B, IS629 YP_002406255.1 245034 R 585057 CDS YP_002406256.1 218698627 7149523 complement(245921..246247) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 246247 7149523 ECIAI39_0211 Escherichia coli IAI39 transposase ORF A, IS629 YP_002406256.1 245921 R 585057 CDS YP_002406257.1 218698628 7150674 247361..247735 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1956303, 7984428, 14645275; hypothetical protein 247735 ybaJ 7150674 ybaJ Escherichia coli IAI39 hypothetical protein YP_002406257.1 247361 D 585057 CDS YP_002406258.1 218698629 7153285 247761..247979 1 NC_011750.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein 247979 hha 7153285 hha Escherichia coli IAI39 hemolysin expression-modulating protein YP_002406258.1 247761 D 585057 CDS YP_002406259.1 218698630 7151643 248151..248702 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82180540, 91310703, 9600841; Product type e : enzyme; maltose O-acetyltransferase 248702 maa 7151643 maa Escherichia coli IAI39 maltose O-acetyltransferase YP_002406259.1 248151 D 585057 CDS YP_002406260.1 218698631 7151990 248818..249288 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 249288 ylaC 7151990 ylaC Escherichia coli IAI39 hypothetical protein YP_002406260.1 248818 D 585057 CDS YP_002406261.1 218698632 7154365 249452..251002 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 251002 ylaB 7154365 ylaB Escherichia coli IAI39 hypothetical protein YP_002406261.1 249452 D 585057 CDS YP_002406262.1 218698633 7154364 complement(251043..251396) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 251396 ybaA 7154364 ybaA Escherichia coli IAI39 hypothetical protein YP_002406262.1 251043 R 585057 CDS YP_002406263.1 218698634 7151311 251697..252086 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methylated DNA-protein cysteine alkyltransferase 252086 ybaZ 7151311 ybaZ Escherichia coli IAI39 putative methylated DNA-protein cysteine alkyltransferase YP_002406263.1 251697 D 585057 CDS YP_002406264.1 218698635 7153292 complement(252117..252689) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative lipoprotein 252689 ybaY 7153292 ybaY Escherichia coli IAI39 putative lipoprotein YP_002406264.1 252117 R 585057 CDS YP_002406265.1 218698636 7153291 252907..253767 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86139906, 91250410, 10876240; Product type e : enzyme; acyl-CoA thioesterase II 253767 tesB 7153291 tesB Escherichia coli IAI39 acyl-CoA thioesterase II YP_002406265.1 252907 D 585057 CDS YP_002406266.1 218698637 7152963 complement(253816..255102) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22020597, 9618533, 10931328, 1645722, 7984428; Product type t : transporter; ammonium transporter 255102 amtB 7152963 amtB Escherichia coli IAI39 ammonium transporter YP_002406266.1 253816 R 585057 CDS YP_002406267.1 218698638 7150734 complement(255132..255470) 1 NC_011750.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 255470 glnK 7150734 glnK Escherichia coli IAI39 nitrogen regulatory protein P-II 2 YP_002406267.1 255132 R 585057 CDS YP_002406268.1 218698639 7151529 complement(255651..257432) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 94124004; Product type pt : putative transporter; putative multidrug transporter membrane\ATP-binding proteins 257432 mdlB 7151529 mdlB Escherichia coli IAI39 putative multidrug transporter membrane\ATP-binding proteins YP_002406268.1 255651 R 585057 CDS YP_002406269.1 218698640 7152023 complement(257425..259197) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 94124004, 10850996; Product type pt : putative transporter; putative multidrug transporter membrane\ATP-binding proteins 259197 mdlA 7152023 mdlA Escherichia coli IAI39 putative multidrug transporter membrane\ATP-binding proteins YP_002406269.1 257425 R 585057 CDS YP_002406270.1 218698641 7152022 complement(259227..259685) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7904973, 10850996; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 259685 ybaO 7152022 ybaO Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002406270.1 259227 R 585057 CDS YP_002406271.1 218698642 7153288 complement(259838..260656) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217; Product type e : enzyme; thiamin pyrimidine pyrophosphate hydrolase 260656 cof 7153288 cof Escherichia coli IAI39 thiamin pyrimidine pyrophosphate hydrolase YP_002406271.1 259838 R 585057 CDS YP_002406272.1 218698643 7150982 260756..262456 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 262456 ybaE 7150982 ybaE Escherichia coli IAI39 hypothetical protein YP_002406272.1 260756 D 585057 CDS YP_002406273.1 218698644 7153284 262521..263216 1 NC_011750.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC 263216 queC 7153284 queC Escherichia coli IAI39 queuosine biosynthesis protein QueC YP_002406273.1 262521 D 585057 CDS YP_002406274.1 218698645 7152561 complement(263268..263666) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 263666 ybaW 7152561 ybaW Escherichia coli IAI39 hypothetical protein YP_002406274.1 263268 R 585057 CDS YP_002406275.1 218698646 7153290 complement(263772..264143) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 264143 ybaV 7153290 ybaV Escherichia coli IAI39 hypothetical protein YP_002406275.1 263772 R 585057 CDS YP_002406276.1 218698647 7153289 complement(264294..266165) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9670013; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase D 266165 ppiD 7153289 ppiD Escherichia coli IAI39 peptidyl-prolyl cis-trans isomerase D YP_002406276.1 264294 R 585057 CDS YP_002406277.1 218698648 7152463 complement(266357..266629) 1 NC_011750.1 histone-like DNA-binding protein; transcriptional regulator HU subunit beta 266629 hupB 7152463 hupB Escherichia coli IAI39 transcriptional regulator HU subunit beta YP_002406277.1 266357 R 585057 CDS YP_002406278.1 218698649 7151692 complement(266838..269192) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10094703, 14665623, 8939438, 91072263, 97137085, 2984174, 3042779, 3289547, 7988699, 8226758, 8294008; Product type e : enzyme; DNA-binding ATP-dependent protease La 269192 lon 7151692 lon Escherichia coli IAI39 DNA-binding ATP-dependent protease La YP_002406278.1 266838 R 585057 CDS YP_002406279.1 218698650 7152892 complement(269380..270654) 1 NC_011750.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 270654 clpX 7152892 clpX Escherichia coli IAI39 ATP-dependent protease ATP-binding subunit ClpX YP_002406279.1 269380 R 585057 CDS YP_002406280.1 218698651 7150967 complement(270780..271403) 1 NC_011750.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 271403 clpP 7150967 clpP Escherichia coli IAI39 ATP-dependent Clp protease proteolytic subunit YP_002406280.1 270780 R 585057 CDS YP_002406281.1 218698652 7150965 complement(271649..272947) 1 NC_011750.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 272947 tig 7150965 tig Escherichia coli IAI39 trigger factor YP_002406281.1 271649 R 585057 CDS YP_002406282.1 218698653 7152986 complement(273291..273608) 1 NC_011750.1 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA 273608 bolA 7152986 bolA Escherichia coli IAI39 transcriptional regulator BolA YP_002406282.1 273291 R 585057 CDS YP_002406283.1 218698654 7150873 273913..274491 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 274491 yajG 7150873 yajG Escherichia coli IAI39 hypothetical protein YP_002406283.1 273913 D 585057 CDS YP_002406284.1 218698655 7153276 274535..276010 1 NC_011750.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter 276010 ampG 7153276 ampG Escherichia coli IAI39 muropeptide transporter YP_002406284.1 274535 D 585057 CDS YP_002406285.1 218698656 7150732 276470..277417 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92112945, 92371427, 9378722, 98021084, 11017202, 1322173, 2162835, 2162837, 2165491, 2168206, 8231804, 8618822; Product type c : carrier; cytochrome o ubiquinol oxidase subunit II 277417 cyoA 7150732 cyoA Escherichia coli IAI39 cytochrome o ubiquinol oxidase subunit II YP_002406285.1 276470 D 585057 CDS YP_002406286.1 218698657 7151050 277439..279430 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 92345252, 93349845, 9378722, 98021084, 11017202, 2162835, 2168206; Product type c : carrier; cytochrome o ubiquinol oxidase subunit I 279430 cyoB 7151050 cyoB Escherichia coli IAI39 cytochrome o ubiquinol oxidase subunit I YP_002406286.1 277439 D 585057 CDS YP_002406287.1 218698658 7151051 279420..280034 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 92345252, 93349845, 9378722, 98021084, 11017202, 2162835, 2168206; Product type c : carrier; cytochrome o ubiquinol oxidase subunit III 280034 cyoC 7151051 cyoC Escherichia coli IAI39 cytochrome o ubiquinol oxidase subunit III YP_002406287.1 279420 D 585057 CDS YP_002406288.1 218698659 7151052 280034..280363 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 90366572, 92345252, 9378722, 98021084, 11017202, 2162835; Product type c : carrier; cytochrome o ubiquinol oxidase subunit IV 280363 cyoD 7151052 cyoD Escherichia coli IAI39 cytochrome o ubiquinol oxidase subunit IV YP_002406288.1 280034 D 585057 CDS YP_002406289.1 218698660 7151053 280375..281265 1 NC_011750.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 281265 cyoE 7151053 cyoE Escherichia coli IAI39 protoheme IX farnesyltransferase YP_002406289.1 280375 D 585057 CDS YP_002406290.1 218698661 7151054 281384..281761 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 281761 7151054 ECIAI39_0246 Escherichia coli IAI39 hypothetical protein YP_002406290.1 281384 D 585057 CDS YP_002406291.1 218698662 7149525 281745..282287 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase 282287 7149525 ECIAI39_0247 Escherichia coli IAI39 putative acetyltransferase YP_002406291.1 281745 D 585057 CDS YP_002406292.1 218698663 7149526 complement(282343..283338) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative zinc-dependent hydrolase 283338 7149526 ECIAI39_0248 Escherichia coli IAI39 putative zinc-dependent hydrolase YP_002406292.1 282343 R 585057 CDS YP_002406293.1 218698664 7149527 283685..285049 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 285049 yajR 7149527 yajR Escherichia coli IAI39 putative MFS superfamily transporter YP_002406293.1 283685 D 585057 CDS YP_002406294.1 218698665 7153281 complement(285177..285668) 1 NC_011750.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; putative nucleotide-binding protein 285668 yajQ 7153281 yajQ Escherichia coli IAI39 putative nucleotide-binding protein YP_002406294.1 285177 R 585057 CDS YP_002406295.1 218698666 7153280 285836..286747 1 NC_011750.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 286747 panE 7153280 panE Escherichia coli IAI39 2-dehydropantoate 2-reductase YP_002406295.1 285836 D 585057 CDS YP_002406296.1 218698667 7152326 286710..287300 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 97039868, 99173753, 99311269; DJ-1 family protein 287300 yajL 7152326 yajL Escherichia coli IAI39 DJ-1 family protein YP_002406296.1 286710 D 585057 CDS YP_002406297.1 218698668 7153278 complement(287354..288802) 1 NC_011750.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 288802 thiI 7153278 thiI Escherichia coli IAI39 thiamine biosynthesis protein ThiI YP_002406297.1 287354 R 585057 CDS YP_002406298.1 218698669 7152971 289008..289250 1 NC_011750.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 289250 xseB 7152971 xseB Escherichia coli IAI39 exodeoxyribonuclease VII small subunit YP_002406298.1 289008 D 585057 CDS YP_002406299.1 218698670 7153183 289250..290149 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89291702, 91210228; Product type e : enzyme; geranyltranstransferase 290149 ispA 7153183 ispA Escherichia coli IAI39 geranyltranstransferase YP_002406299.1 289250 D 585057 CDS YP_002406300.1 218698671 7151851 290174..292036 1 NC_011750.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 292036 dxs 7151851 dxs Escherichia coli IAI39 1-deoxy-D-xylulose-5-phosphate synthase YP_002406300.1 290174 D 585057 CDS YP_002406301.1 218698672 7151190 292091..293065 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217, 16077126; Product type e : enzyme; aldoketo-oxidoreductase, NADP-binding 293065 yajO 7151190 yajO Escherichia coli IAI39 aldoketo-oxidoreductase, NADP-binding YP_002406301.1 292091 D 585057 CDS YP_002406302.1 218698673 7153279 complement(293119..293637) 1 NC_011750.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 293637 pgpA 7153279 pgpA Escherichia coli IAI39 phosphatidylglycerophosphatase A YP_002406302.1 293119 R 585057 CDS YP_002406303.1 218698674 7152385 complement(293615..294592) 1 NC_011750.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 294592 thiL 7152385 thiL Escherichia coli IAI39 thiamine monophosphate kinase YP_002406303.1 293615 R 585057 CDS YP_002406304.1 218698675 7152972 complement(294670..295089) 1 NC_011750.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 295089 nusB 7152972 nusB Escherichia coli IAI39 transcription antitermination protein NusB YP_002406304.1 294670 R 585057 CDS YP_002406305.1 218698676 7152285 complement(295109..295579) 1 NC_011750.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 295579 ribH 7152285 ribH Escherichia coli IAI39 6,7-dimethyl-8-ribityllumazine synthase YP_002406305.1 295109 R 585057 CDS YP_002406306.1 218698677 7152629 complement(295668..296771) 1 NC_011750.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 296771 ribD 7152629 ribD Escherichia coli IAI39 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase YP_002406306.1 295668 R 585057 CDS YP_002406307.1 218698678 7152628 complement(296775..297224) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator NrdR 297224 nrdR 7152628 nrdR Escherichia coli IAI39 transcriptional regulator NrdR YP_002406307.1 296775 R 585057 CDS YP_002406308.1 218698679 7152252 297315..297563 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 297563 7152252 ECIAI39_0264 Escherichia coli IAI39 hypothetical protein YP_002406308.1 297315 D 585057 CDS YP_002406309.1 218698680 7149528 complement(297548..298756) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase 298756 ydcM 7149528 ydcM Escherichia coli IAI39 putative transposase YP_002406309.1 297548 R 585057 CDS YP_002406310.1 218698681 7153527 298772..299050 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF A (fragment), IS609 299050 7153527 ECIAI39_0266 Escherichia coli IAI39 transposase ORF A (fragment), IS609 YP_002406310.1 298772 D 585057 CDS YP_002406311.1 218698682 7153277 299960..300844 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91092502, 91358319, 93352541; Product type m : membrane component; nucleoside channel phage T6/colicin K receptor 300844 tsx 7153277 tsx Escherichia coli IAI39 nucleoside channel phage T6/colicin K receptor YP_002406311.1 299960 D 585057 CDS YP_002406312.1 218698683 7153049 complement(300882..301229) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 301229 yajD 7153049 yajD Escherichia coli IAI39 hypothetical protein YP_002406312.1 300882 R 585057 CDS YP_002406313.1 218698684 7153275 complement(301317..301631) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative toxin antitoxin plasmid stabilization system protein 301631 7153275 ECIAI39_0270 Escherichia coli IAI39 putative toxin antitoxin plasmid stabilization system protein YP_002406313.1 301317 R 585057 CDS YP_002406314.1 218698685 7149530 complement(301591..301833) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative toxin antitoxin plasmid stabilisation system containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain 301833 7149530 ECIAI39_0271 Escherichia coli IAI39 putative toxin antitoxin plasmid stabilisation system containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain YP_002406314.1 301591 R 585057 CDS YP_002406315.1 218698686 7149531 complement(301985..302956) 1 NC_011750.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 302956 secF 7149531 secF Escherichia coli IAI39 preprotein translocase subunit SecF YP_002406315.1 301985 R 585057 CDS YP_002406316.1 218698687 7152822 complement(302967..304814) 1 NC_011750.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 304814 secD 7152822 secD Escherichia coli IAI39 preprotein translocase subunit SecD YP_002406316.1 302967 R 585057 CDS YP_002406317.1 218698688 7152820 complement(304842..305174) 1 NC_011750.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 305174 yajC 7152820 yajC Escherichia coli IAI39 preprotein translocase subunit YajC YP_002406317.1 304842 R 585057 CDS YP_002406318.1 218698689 7153274 complement(305197..306324) 1 NC_011750.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 306324 tgt 7153274 tgt Escherichia coli IAI39 queuine tRNA-ribosyltransferase YP_002406318.1 305197 R 585057 CDS YP_002406319.1 218698690 7152964 complement(306379..307449) 1 NC_011750.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 307449 queA 7152964 queA Escherichia coli IAI39 S-adenosylmethionine:tRNA ribosyltransferase-isomerase YP_002406319.1 306379 R 585057 CDS YP_002406320.1 218698691 7152560 307542..308123 1 NC_011750.1 Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; acyl carrier protein phosphodiesterase 308123 acpH 7152560 acpH Escherichia coli IAI39 acyl carrier protein phosphodiesterase YP_002406320.1 307542 D 585057 CDS YP_002406321.1 218698692 7150668 complement(308144..309589) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 309589 7150668 ECIAI39_0278 Escherichia coli IAI39 hypothetical protein YP_002406321.1 308144 R 585057 CDS YP_002406322.1 218698693 7149532 complement(309775..311592) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92184757, 1706703, 1918057; Product type e : enzyme; maltodextrin glucosidase 311592 malZ 7149532 malZ Escherichia coli IAI39 maltodextrin glucosidase YP_002406322.1 309775 R 585057 CDS YP_002406323.1 218698694 7152007 complement(311748..313121) 1 NC_011750.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; putative proline-specific permease 313121 proY 7152007 proY Escherichia coli IAI39 putative proline-specific permease YP_002406323.1 311748 R 585057 CDS YP_002406324.1 218698695 7152492 complement(313197..314516) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3078876, 6998958, 3550103, 7984428; Product type t : transporter; branched chain amino acid transporter 314516 brnQ 7152492 brnQ Escherichia coli IAI39 branched chain amino acid transporter YP_002406324.1 313197 R 585057 CDS YP_002406325.1 218698696 7150875 complement(314923..316218) 1 NC_011750.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 316218 phoR 7150875 phoR Escherichia coli IAI39 phosphate regulon sensor protein YP_002406325.1 314923 R 585057 CDS YP_002406326.1 218698697 7152415 complement(316276..316965) 1 NC_011750.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 316965 phoB 7152415 phoB Escherichia coli IAI39 transcriptional regulator PhoB YP_002406326.1 316276 R 585057 CDS YP_002406327.1 218698698 7152410 317155..318357 1 NC_011750.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease subunit SbcD 318357 sbcD 7152410 sbcD Escherichia coli IAI39 exonuclease subunit SbcD YP_002406327.1 317155 D 585057 CDS YP_002406328.1 218698699 7152806 318354..321497 1 NC_011750.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease subunit SbcC 321497 sbcC 7152806 sbcC Escherichia coli IAI39 exonuclease subunit SbcC YP_002406328.1 318354 D 585057 CDS YP_002406329.1 218698700 7152805 321623..322807 1 NC_011750.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ 322807 araJ 7152805 araJ Escherichia coli IAI39 MFS transport protein AraJ YP_002406329.1 321623 D 585057 CDS YP_002406330.1 218698701 7150755 complement(322947..323855) 1 NC_011750.1 catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 323855 mak 7150755 mak Escherichia coli IAI39 fructokinase YP_002406330.1 322947 R 585057 CDS YP_002406331.1 218698702 7151994 323980..324891 1 NC_011750.1 Required for efficient pilin antigenic variation; recombination associated protein 324891 rdgC 7151994 rdgC Escherichia coli IAI39 recombination associated protein YP_002406331.1 323980 D 585057 CDS YP_002406332.1 218698703 7152582 complement(325049..325327) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 325327 ykiA 7152582 ykiA Escherichia coli IAI39 hypothetical protein YP_002406332.1 325049 R 585057 CDS YP_002406333.1 218698704 7154363 complement(325535..325819) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 325819 yaiE 7154363 yaiE Escherichia coli IAI39 hypothetical protein YP_002406333.1 325535 R 585057 CDS YP_002406334.1 218698705 7153259 complement(325891..326568) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 86085675, 3001025; hypothetical protein 326568 aroM 7153259 aroM Escherichia coli IAI39 hypothetical protein YP_002406334.1 325891 R 585057 CDS YP_002406335.1 218698706 7150785 complement(326826..327017) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 327017 yaiA 7150785 yaiA Escherichia coli IAI39 hypothetical protein YP_002406335.1 326826 R 585057 CDS YP_002406336.1 218698707 7153256 complement(327067..327591) 1 NC_011750.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase II 327591 aroL 7153256 aroL Escherichia coli IAI39 shikimate kinase II YP_002406336.1 327067 R 585057 CDS YP_002406337.1 218698708 7150784 complement(327774..328232) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 328232 yaiI 7150784 yaiI Escherichia coli IAI39 hypothetical protein YP_002406337.1 327774 R 585057 CDS YP_002406338.1 218698709 7153260 328352..329161 1 NC_011750.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 329161 proC 7153260 proC Escherichia coli IAI39 pyrroline-5-carboxylate reductase YP_002406338.1 328352 D 585057 CDS YP_002406339.1 218698710 7152485 complement(329178..330293) 1 NC_011750.1 catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA 330293 adrA 7152485 adrA Escherichia coli IAI39 diguanylate cyclase AdrA YP_002406339.1 329178 R 585057 CDS YP_002406340.1 218698711 7153258 complement(330395..330715) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3533724, 2160940; Product type f : factor; hypothetical protein 330715 psiF 7153258 psiF Escherichia coli IAI39 hypothetical protein YP_002406340.1 330395 R 585057 CDS YP_002406341.1 218698712 7152501 complement(330834..332249) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme; alkaline phosphatase 332249 phoA 7152501 phoA Escherichia coli IAI39 alkaline phosphatase YP_002406341.1 330834 R 585057 CDS YP_002406342.1 218698713 7152409 complement(332349..332609) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 332609 yaiB 7152409 yaiB Escherichia coli IAI39 hypothetical protein YP_002406342.1 332349 R 585057 CDS YP_002406343.1 218698714 7153257 complement(332791..332994) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 332994 7153257 ECIAI39_0300 Escherichia coli IAI39 hypothetical protein YP_002406343.1 332791 R 585057 CDS YP_002406344.1 218698715 7149533 333072..334166 1 NC_011750.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 334166 ddl 7149533 ddl Escherichia coli IAI39 D-alanyl-alanine synthetase A YP_002406344.1 333072 D 585057 CDS YP_002406345.1 218698716 7151102 complement(334190..334534) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 334534 yaiZ 7151102 yaiZ Escherichia coli IAI39 hypothetical protein YP_002406345.1 334190 R 585057 CDS YP_002406346.1 218698717 7153273 334662..334970 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 334970 yaiY 7153273 yaiY Escherichia coli IAI39 hypothetical protein YP_002406346.1 334662 D 585057 CDS YP_002406347.1 218698718 7153272 complement(335028..336122) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative lipoprotein 336122 yaiW 7153272 yaiW Escherichia coli IAI39 putative lipoprotein YP_002406347.1 335028 R 585057 CDS YP_002406348.1 218698719 7153269 complement(336135..337355) 1 NC_011750.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transport protein 337355 sbmA 7153269 sbmA Escherichia coli IAI39 transport protein YP_002406348.1 336135 R 585057 CDS YP_002406349.1 218698720 7152807 complement(337375..337569) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 337569 7152807 ECIAI39_0306 Escherichia coli IAI39 hypothetical protein YP_002406349.1 337375 R 585057 CDS YP_002406350.1 218698721 7149534 337707..338864 1 NC_011750.1 this protein has no known enzymatic function; beta-lactam binding protein AmpH 338864 ampH 7149534 ampH Escherichia coli IAI39 beta-lactam binding protein AmpH YP_002406350.1 337707 D 585057 CDS YP_002406351.1 218698722 7150733 complement(338865..339533) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative DNA-binding transcriptional regulator 339533 yaiV 7150733 yaiV Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002406351.1 338865 R 585057 CDS YP_002406352.1 218698723 7153268 complement(339574..342483) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative flagellin-like structural protein 342483 7153268 ECIAI39_0309 Escherichia coli IAI39 putative flagellin-like structural protein YP_002406352.1 339574 R 585057 CDS YP_002406353.1 218698724 7149535 343009..343983 1 NC_011750.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 343983 hemB 7149535 hemB Escherichia coli IAI39 delta-aminolevulinic acid dehydratase YP_002406353.1 343009 D 585057 CDS YP_002406354.1 218698725 7151625 344142..344468 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 344468 7151625 ECIAI39_0311 Escherichia coli IAI39 transposase ORF A, IS629 YP_002406354.1 344142 D 585057 CDS YP_002406355.1 218698726 7149536 344465..345355 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 345355 7149536 ECIAI39_0312 Escherichia coli IAI39 transposase ORF B, IS629 YP_002406355.1 344465 D 585057 CDS YP_002406356.1 218698727 7149537 complement(345237..346364) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; taurine dioxygenase, 2-oxoglutarate-dependent 346364 tauD 7149537 tauD Escherichia coli IAI39 taurine dioxygenase, 2-oxoglutarate-dependent YP_002406356.1 345237 R 585057 CDS YP_002406357.1 218698728 7152950 complement(346916..347683) 1 NC_011750.1 Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding subunit 347683 tauB 7152950 tauB Escherichia coli IAI39 taurine transporter ATP-binding subunit YP_002406357.1 346916 R 585057 CDS YP_002406358.1 218698729 7152949 complement(347696..348658) 1 NC_011750.1 with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit 348658 tauA 7152949 tauA Escherichia coli IAI39 taurine transporter substrate binding subunit YP_002406358.1 347696 R 585057 CDS YP_002406359.1 218698730 7152948 349267..349938 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 349938 yaiS 7152948 yaiS Escherichia coli IAI39 hypothetical protein YP_002406359.1 349267 D 585057 CDS YP_002406360.1 218698731 7153266 349948..351144 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated glycosyltransferase 351144 yaiP 7153266 yaiP Escherichia coli IAI39 putative membrane-associated glycosyltransferase YP_002406360.1 349948 D 585057 CDS YP_002406361.1 218698732 7153264 351122..351703 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transferase 351703 yaiX 7153264 yaiX Escherichia coli IAI39 putative transferase YP_002406361.1 351122 D 585057 CDS YP_002406362.1 218698733 7153270 351705..352478 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 352478 yaiO 7153270 yaiO Escherichia coli IAI39 hypothetical protein YP_002406362.1 351705 D 585057 CDS YP_002406363.1 218698734 7153262 352663..352938 1 NC_011750.1 formaldehyde-induced negative regulator of the frmRAB operon; regulator protein FrmR 352938 frmR 7153262 frmR Escherichia coli IAI39 regulator protein FrmR YP_002406363.1 352663 D 585057 CDS YP_002406364.1 218698735 7151416 352973..354082 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15466022, 87172301, 1731906; Product type e : enzyme; alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase 354082 frmA 7151416 frmA Escherichia coli IAI39 alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase YP_002406364.1 352973 D 585057 CDS YP_002406365.1 218698736 7151413 354174..355007 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16567800, 15466022; Product type e : enzyme; S-formylglutathione hydrolase 355007 frmB 7151413 frmB Escherichia coli IAI39 S-formylglutathione hydrolase YP_002406365.1 354174 D 585057 CDS YP_002406366.1 218698737 7151414 complement(355133..355672) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15115803, 12878731, 13129938; Product type e : enzyme; nucleoprotein/polynucleotide-associated enzyme 355672 yaiL 7151414 yaiL Escherichia coli IAI39 nucleoprotein/polynucleotide-associated enzyme YP_002406366.1 355133 R 585057 CDS YP_002406367.1 218698738 7153261 complement(355774..356928) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7961399; Product type t : transporter; putative 3-hydroxyphenylpropionic transporter MhpT 356928 mhpT 7153261 mhpT Escherichia coli IAI39 putative 3-hydroxyphenylpropionic transporter MhpT YP_002406367.1 355774 R 585057 CDS YP_002406368.1 218698739 7152077 complement(357164..358177) 1 NC_011750.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 358177 mhpE 7152077 mhpE Escherichia coli IAI39 4-hydroxy-2-ketovalerate aldolase YP_002406368.1 357164 R 585057 CDS YP_002406369.1 218698740 7152074 complement(358174..359124) 1 NC_011750.1 catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 359124 mhpF 7152074 mhpF Escherichia coli IAI39 acetaldehyde dehydrogenase YP_002406369.1 358174 R 585057 CDS YP_002406370.1 218698741 7152075 complement(359121..359930) 1 NC_011750.1 catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid; 2-keto-4-pentenoate hydratase 359930 mhpD 7152075 mhpD Escherichia coli IAI39 2-keto-4-pentenoate hydratase YP_002406370.1 359121 R 585057 CDS YP_002406371.1 218698742 7152073 complement(359940..360821) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87008429, 94002258, 15663942; Product type e : enzyme; 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase 360821 mhpC 7152073 mhpC Escherichia coli IAI39 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase YP_002406371.1 359940 R 585057 CDS YP_002406372.1 218698743 7152072 complement(360824..361768) 1 NC_011750.1 catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family; 3-(2,3-dihydroxyphenyl)propionate dioxygenase 361768 mhpB 7152072 mhpB Escherichia coli IAI39 3-(2,3-dihydroxyphenyl)propionate dioxygenase YP_002406372.1 360824 R 585057 CDS YP_002406373.1 218698744 7152071 complement(361770..363434) 1 NC_011750.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 363434 mhpA 7152071 mhpA Escherichia coli IAI39 3-(3-hydroxyphenyl)propionate hydroxylase YP_002406373.1 361770 R 585057 CDS YP_002406374.1 218698745 7152070 363613..364458 1 NC_011750.1 activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional activator MhpR 364458 mhpR 7152070 mhpR Escherichia coli IAI39 DNA-binding transcriptional activator MhpR YP_002406374.1 363613 D 585057 CDS YP_002406375.1 218698746 7152076 364535..365617 1 NC_011750.1 transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor 365617 lacI 7152076 lacI Escherichia coli IAI39 lac repressor YP_002406375.1 364535 D 585057 CDS YP_002406376.1 218698747 7151913 365740..368814 1 NC_011750.1 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon; beta-D-galactosidase 368814 lacZ 7151913 lacZ Escherichia coli IAI39 beta-D-galactosidase YP_002406376.1 365740 D 585057 CDS YP_002406377.1 218698748 7151915 368866..370119 1 NC_011750.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease 370119 lacY 7151915 lacY Escherichia coli IAI39 galactoside permease YP_002406377.1 368866 D 585057 CDS YP_002406378.1 218698749 7151914 370185..370796 1 NC_011750.1 transfers acetyl group from acetyl-CoA to the 6-hydroxyl of galactopyranosides; exact physiological role is unknown; galactoside O-acetyltransferase 370796 lacA 7151914 lacA Escherichia coli IAI39 galactoside O-acetyltransferase YP_002406378.1 370185 D 585057 CDS YP_002406379.1 218698750 7151912 complement(370884..372038) 1 NC_011750.1 MFS transporter family member induced in the presence of cyanate as part of a 3 gene operon; not essential; putative cyanate transporter 372038 cynX 7151912 cynX Escherichia coli IAI39 putative cyanate transporter YP_002406379.1 370884 R 585057 CDS YP_002406380.1 218698751 7151049 complement(372071..372541) 1 NC_011750.1 catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide; cyanate hydratase 372541 cynS 7151049 cynS Escherichia coli IAI39 cyanate hydratase YP_002406380.1 372071 R 585057 CDS YP_002406381.1 218698752 7151047 complement(372572..373231) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91242169, 92156106, 94075239, 3049588; Product type e : enzyme; carbonic anhydrase 373231 cynT 7151047 cynT Escherichia coli IAI39 carbonic anhydrase YP_002406381.1 372572 R 585057 CDS YP_002406382.1 218698753 7151048 373341..374240 1 NC_011750.1 controls the expression of the cynTSX operon involved in degrading and using cyanate as a sole nitrogen source; DNA-binding transcriptional regulator CynR 374240 cynR 7151048 cynR Escherichia coli IAI39 DNA-binding transcriptional regulator CynR YP_002406382.1 373341 D 585057 CDS YP_002406383.1 218698754 7151046 374364..374894 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 374894 7151046 ECIAI39_0341 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002406383.1 374364 D 585057 CDS YP_002406384.1 218698755 7149538 374999..375721 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 375721 7149538 ECIAI39_0342 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002406384.1 374999 D 585057 CDS YP_002406385.1 218698756 7149539 complement(375809..377092) 1 NC_011750.1 Catalyzes the deamination of cytosine to uracil and ammonia; cytosine deaminase 377092 codA 7149539 codA Escherichia coli IAI39 cytosine deaminase YP_002406385.1 375809 R 585057 CDS YP_002406386.1 218698757 7150980 complement(377082..378341) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92349961; Product type t : transporter; cytosine permease 378341 codB 7150980 codB Escherichia coli IAI39 cytosine permease YP_002406386.1 377082 R 585057 CDS YP_002406387.1 218698758 7150981 complement(378579..380465) 1 NC_011750.1 catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; propionyl-CoA synthetase 380465 prpE 7150981 prpE Escherichia coli IAI39 propionyl-CoA synthetase YP_002406387.1 378579 R 585057 CDS YP_002406388.1 218698759 7152496 complement(380505..381956) 1 NC_011750.1 functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C; 2-methylcitrate dehydratase 381956 prpD 7152496 prpD Escherichia coli IAI39 2-methylcitrate dehydratase YP_002406388.1 380505 R 585057 CDS YP_002406389.1 218698760 7152495 complement(381990..383159) 1 NC_011750.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase 383159 prpC 7152495 prpC Escherichia coli IAI39 methylcitrate synthase YP_002406389.1 381990 R 585057 CDS YP_002406390.1 218698761 7152494 complement(383319..384209) 1 NC_011750.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase 384209 prpB 7152494 prpB Escherichia coli IAI39 2-methylisocitrate lyase YP_002406390.1 383319 R 585057 CDS YP_002406391.1 218698762 7152493 384448..386034 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9325432, 15805526; Product type r : regulator; DNA-binding transcriptional activator 386034 prpR 7152493 prpR Escherichia coli IAI39 DNA-binding transcriptional activator YP_002406391.1 384448 D 585057 CDS YP_002406392.1 218698763 7152497 complement(386132..386407) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 386407 yahO 7152497 yahO Escherichia coli IAI39 hypothetical protein YP_002406392.1 386132 R 585057 CDS YP_002406393.1 218698764 7153255 386554..387225 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12879215; Product type t : transporter; neutral amino-acid efflux system 387225 yahN 7153255 yahN Escherichia coli IAI39 neutral amino-acid efflux system YP_002406393.1 386554 D 585057 CDS YP_002406394.1 218698765 7153254 complement(387250..387486) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 387486 yahM 7153254 yahM Escherichia coli IAI39 hypothetical protein YP_002406394.1 387250 R 585057 CDS YP_002406395.1 218698766 7150637 complement(387900..388715) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 388715 yahL 7150637 yahL Escherichia coli IAI39 hypothetical protein YP_002406395.1 387900 R 585057 CDS YP_002406396.1 218698767 7153251 complement(390093..391079) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; sugar ABC transporter permease 391079 7153251 ECIAI39_0357 Escherichia coli IAI39 sugar ABC transporter permease YP_002406396.1 390093 R 585057 CDS YP_002406397.1 218698768 7149540 complement(391046..392032) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; sugar ABC transporter permease 392032 7149540 ECIAI39_0358 Escherichia coli IAI39 sugar ABC transporter permease YP_002406397.1 391046 R 585057 CDS YP_002406398.1 218698769 7149541 complement(392010..393509) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-binding protein of ABC sugar transport system 393509 7149541 ECIAI39_0359 Escherichia coli IAI39 putative ATP-binding protein of ABC sugar transport system YP_002406398.1 392010 R 585057 CDS YP_002406399.1 218698770 7149542 complement(393543..394529) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; ribose ABC transporter substrate-binding protein 394529 7149542 ECIAI39_0360 Escherichia coli IAI39 ribose ABC transporter substrate-binding protein YP_002406399.1 393543 R 585057 CDS YP_002406400.1 218698771 7149543 complement(394627..394704) 1 NC_011750.1 hypothetical protein 394704 7149543 ECIAI39_0361 Escherichia coli IAI39 hypothetical protein YP_002406400.1 394627 R 585057 CDS YP_002406401.1 218698772 7149544 complement(394780..395220) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 395220 7149544 ECIAI39_0362 Escherichia coli IAI39 hypothetical protein YP_002406401.1 394780 R 585057 CDS YP_002406402.1 218698773 7149545 complement(395488..396870) 1 NC_011750.1 metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain; putative deaminase 396870 yahJ 7149545 yahJ Escherichia coli IAI39 putative deaminase YP_002406402.1 395488 R 585057 CDS YP_002406403.1 218698774 7153249 complement(396880..397830) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7711027, 11523892; Product type pe : putative enzyme; putative carbamate kinase 397830 yahI 7153249 yahI Escherichia coli IAI39 putative carbamate kinase YP_002406403.1 396880 R 585057 CDS YP_002406404.1 218698775 7153248 complement(397925..399343) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 399343 yahG 7153248 yahG Escherichia coli IAI39 hypothetical protein YP_002406404.1 397925 R 585057 CDS YP_002406405.1 218698776 7153247 complement(399343..400890) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative enzyme with acyl-CoA domain 400890 yahF 7153247 yahF Escherichia coli IAI39 putative enzyme with acyl-CoA domain YP_002406405.1 399343 R 585057 CDS YP_002406406.1 218698777 7153246 complement(400880..401743) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 401743 yahE 7153246 yahE Escherichia coli IAI39 hypothetical protein YP_002406406.1 400880 R 585057 CDS YP_002406407.1 218698778 7153245 complement(401783..402388) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 402388 yahD 7153245 yahD Escherichia coli IAI39 hypothetical protein YP_002406407.1 401783 R 585057 CDS YP_002406408.1 218698779 7153244 402646..403143 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 403143 yahC 7153244 yahC Escherichia coli IAI39 hypothetical protein YP_002406408.1 402646 D 585057 CDS YP_002406409.1 218698780 7153243 403235..404167 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 404167 yahB 7153243 yahB Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002406409.1 403235 D 585057 CDS YP_002406410.1 218698781 7153242 complement(404209..405297) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15995192; Product type e : enzyme; cyclic di-GMP phosphodiesterase 405297 yahA 7153242 yahA Escherichia coli IAI39 cyclic di-GMP phosphodiesterase YP_002406410.1 404209 R 585057 CDS YP_002406411.1 218698782 7153241 complement(406168..408201) 1 NC_011750.1 proton-motive-force-driven choline transporter; choline transport protein BetT 408201 betT 7153241 betT Escherichia coli IAI39 choline transport protein BetT YP_002406411.1 406168 R 585057 CDS YP_002406412.1 218698783 7150855 408330..408917 1 NC_011750.1 HTH-type; bet1; Repressor involved in choline regulation of the bet genes; transcriptional regulator BetI 408917 betI 7150855 betI Escherichia coli IAI39 transcriptional regulator BetI YP_002406412.1 408330 D 585057 CDS YP_002406413.1 218698784 7150854 408931..410403 1 NC_011750.1 catalyzes the formation of betaine from betaine aldehyde; betaine aldehyde dehydrogenase 410403 betB 7150854 betB Escherichia coli IAI39 betaine aldehyde dehydrogenase YP_002406413.1 408931 D 585057 CDS YP_002406414.1 218698785 7150853 410372..412105 1 NC_011750.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase 412105 betA 7150853 betA Escherichia coli IAI39 choline dehydrogenase YP_002406414.1 410372 D 585057 CDS YP_002406415.1 218698786 7150852 412299..412799 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 412799 7150852 ECIAI39_0376 Escherichia coli IAI39 hypothetical protein YP_002406415.1 412299 D 585057 CDS YP_002406416.1 218698787 7149546 complement(413042..413737) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 413737 ykgG 7149546 ykgG Escherichia coli IAI39 hypothetical protein YP_002406416.1 413042 R 585057 CDS YP_002406417.1 218698788 7154359 complement(413730..415157) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 415157 ykgF 7154359 ykgF Escherichia coli IAI39 putative oxidoreductase YP_002406417.1 413730 R 585057 CDS YP_002406418.1 218698789 7154358 complement(415168..415887) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydroxyacid oxidoreductase (Fe-S centre) 415887 ykgE 7154358 ykgE Escherichia coli IAI39 putative hydroxyacid oxidoreductase (Fe-S centre) YP_002406418.1 415168 R 585057 CDS YP_002406419.1 218698790 7154357 complement(416415..417269) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative AraC-type DNA-binding transcriptional regulator 417269 ykgD 7154357 ykgD Escherichia coli IAI39 putative AraC-type DNA-binding transcriptional regulator YP_002406419.1 416415 R 585057 CDS YP_002406420.1 218698791 7154356 417496..418821 1 NC_011750.1 Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 418821 ykgC 7154356 ykgC Escherichia coli IAI39 pyridine nucleotide-disulfide oxidoreductase YP_002406420.1 417496 D 585057 CDS YP_002406421.1 218698792 7154355 418930..419166 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 419166 ykgI 7154355 ykgI Escherichia coli IAI39 hypothetical protein YP_002406421.1 418930 D 585057 CDS YP_002406422.1 218698793 7154360 419178..419771 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 419771 ykgB 7154360 ykgB Escherichia coli IAI39 hypothetical protein YP_002406422.1 419178 D 585057 CDS YP_002406423.1 218698794 7154354 complement(419931..420815) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative reductase 420815 7154354 ECIAI39_0384 Escherichia coli IAI39 putative reductase YP_002406423.1 419931 R 585057 CDS YP_002406424.1 218698795 7149547 421015..421905 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator ykgA 421905 ykgA 7149547 ykgA Escherichia coli IAI39 putative transcriptional regulator ykgA YP_002406424.1 421015 D 585057 CDS YP_002406425.1 218698796 7151193 426844..427695 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17575004; Product type pe : putative enzyme; putative aldo-keto reductase 427695 7151193 ECIAI39_0388 Escherichia coli IAI39 putative aldo-keto reductase YP_002406425.1 426844 D 585057 CDS YP_002406426.1 218698797 7149548 427722..428711 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldo-keto reductase 428711 7149548 ECIAI39_0389 Escherichia coli IAI39 putative aldo-keto reductase YP_002406426.1 427722 D 585057 CDS YP_002406427.1 218698798 7149549 complement(428742..429716) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, lysR family 429716 7149549 ECIAI39_0390 Escherichia coli IAI39 putative transcriptional regulator, lysR family YP_002406427.1 428742 R 585057 CDS YP_002406428.1 218698799 7149550 complement(429841..430860) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative LysR-like transcriptional regulator 430860 7149550 ECIAI39_0391 Escherichia coli IAI39 putative LysR-like transcriptional regulator YP_002406428.1 429841 R 585057 CDS YP_002406429.1 218698800 7149551 430924..431844 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 431844 7149551 ECIAI39_0392 Escherichia coli IAI39 hypothetical protein YP_002406429.1 430924 D 585057 CDS YP_002406430.1 218698801 7149552 432089..433231 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NADH-dependent flavin oxidoreductase 433231 7149552 ECIAI39_0393 Escherichia coli IAI39 putative NADH-dependent flavin oxidoreductase YP_002406430.1 432089 D 585057 CDS YP_002406431.1 218698802 7149553 434171..434434 1 NC_011750.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B 434434 rpmE2 7149553 rpmE2 Escherichia coli IAI39 50S ribosomal protein L31 type B YP_002406431.1 434171 D 585057 CDS YP_002406432.1 218698803 7154362 434434..434574 1 NC_011750.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 434574 rpmJ 7154362 rpmJ Escherichia coli IAI39 50S ribosomal protein L36 YP_002406432.1 434434 D 585057 CDS YP_002406433.1 218698804 7149554 435268..435543 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 435543 insA 7149554 insA Escherichia coli IAI39 IS1 repressor protein InsA YP_002406433.1 435268 D 585057 CDS YP_002406434.1 218698805 7151780 435462..435965 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 435965 insB 7151780 insB Escherichia coli IAI39 IS1 transposase InsAB' YP_002406434.1 435462 D 585057 CDS YP_002406435.1 218698806 7151791 436058..436648 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 436648 ykgK 7151791 ykgK Escherichia coli IAI39 putative transcriptional regulator YP_002406435.1 436058 D 585057 CDS YP_002406436.1 218698807 7151200 437367..438035 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 438035 yagY 7151200 yagY Escherichia coli IAI39 hypothetical protein YP_002406436.1 437367 D 585057 CDS YP_002406437.1 218698808 7153240 438061..440586 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 440586 yagX 7153240 yagX Escherichia coli IAI39 hypothetical protein YP_002406437.1 438061 D 585057 CDS YP_002406438.1 218698809 7153239 440576..442219 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative surface or exported protein 442219 yagW 7153239 yagW Escherichia coli IAI39 putative surface or exported protein YP_002406438.1 440576 D 585057 CDS YP_002406439.1 218698810 7153238 442188..442898 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 442898 yagV 7153238 yagV Escherichia coli IAI39 hypothetical protein YP_002406439.1 442188 D 585057 CDS YP_002406440.1 218698811 7153237 complement(443789..444403) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 444403 yagU 7153237 yagU Escherichia coli IAI39 hypothetical protein YP_002406440.1 443789 R 585057 CDS YP_002406441.1 218698812 7153236 complement(444618..444791) 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 444791 7153236 ECIAI39_0407 Escherichia coli IAI39 hypothetical protein YP_002406441.1 444618 R 585057 CDS YP_002406442.1 218698813 7150636 complement(445191..446444) 1 NC_011750.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 446444 proA 7150636 proA Escherichia coli IAI39 gamma-glutamyl phosphate reductase YP_002406442.1 445191 R 585057 CDS YP_002406443.1 218698814 7152483 complement(446456..447559) 1 NC_011750.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 447559 proB 7152483 proB Escherichia coli IAI39 gamma-glutamyl kinase YP_002406443.1 446456 R 585057 CDS YP_002406444.1 218698815 7152484 447848..448903 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89178658, 89380253, 92219258, 98090453, 1380671, 1848301, 1848682, 6089111, 6341601, 7679770; Product type t : transporter; outer membrane phosphoporin protein E 448903 phoE 7152484 phoE Escherichia coli IAI39 outer membrane phosphoporin protein E YP_002406444.1 447848 D 585057 CDS YP_002406445.1 218698816 7152411 complement(448942..449343) 1 NC_011750.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 449343 crl 7152411 crl Escherichia coli IAI39 DNA-binding transcriptional regulator Crl YP_002406445.1 448942 R 585057 CDS YP_002406446.1 218698817 7150998 complement(449401..450645) 1 NC_011750.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 450645 frsA 7150998 frsA Escherichia coli IAI39 fermentation/respiration switch protein YP_002406446.1 449401 R 585057 CDS YP_002406447.1 218698818 7151418 complement(450737..451195) 1 NC_011750.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 451195 gpt 7151418 gpt Escherichia coli IAI39 xanthine-guanine phosphoribosyltransferase YP_002406447.1 450737 R 585057 CDS YP_002406448.1 218698819 7151582 451456..452913 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1695895, 21101837, 88121730, 92204123, 2651887; Product type e : enzyme; aminoacyl-histidine dipeptidase 452913 pepD 7151582 pepD Escherichia coli IAI39 aminoacyl-histidine dipeptidase YP_002406448.1 451456 D 585057 CDS YP_002406449.1 218698820 7152363 complement(452970..453470) 1 NC_011750.1 similar to release factor 1 and 2; peptide chain release factor-like protein 453470 prfH 7152363 prfH Escherichia coli IAI39 peptide chain release factor-like protein YP_002406449.1 452970 R 585057 CDS YP_002406450.1 218698821 7152475 complement(453581..454732) 1 NC_011750.1 mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY; hypothetical protein 454732 7152475 ECIAI39_0416 Escherichia coli IAI39 hypothetical protein YP_002406450.1 453581 R 585057 CDS YP_002406451.1 218698822 7149556 complement(454911..455363) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12813093; Product type pe : putative enzyme; hypothetical protein 455363 yafP 7149556 yafP Escherichia coli IAI39 hypothetical protein YP_002406451.1 454911 R 585057 CDS YP_002406452.1 218698823 7153232 complement(455360..456415) 1 NC_011750.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 456415 dinB 7153232 dinB Escherichia coli IAI39 DNA polymerase IV YP_002406452.1 455360 R 585057 CDS YP_002406453.1 218698824 7151137 complement(456486..457271) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15687208; Product type s : structure; hypothetical protein 457271 mbhA 7151137 mbhA Escherichia coli IAI39 hypothetical protein YP_002406453.1 456486 R 585057 CDS YP_002406454.1 218698825 7152019 457216..458901 1 NC_011750.1 Evidence 7 : Gene remnant; Product type s : structure; flagellar system protein 458901 fhiA 7152019 fhiA Escherichia coli IAI39 flagellar system protein YP_002406454.1 457216 D 585057 CDS YP_002406455.1 218698826 7151312 complement(459067..459564) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 459564 yafM 7151312 yafM Escherichia coli IAI39 hypothetical protein YP_002406455.1 459067 R 585057 CDS YP_002406456.1 218698827 7153231 complement(459740..460489) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported hydrolase 460489 yafL 7153231 yafL Escherichia coli IAI39 putative exported hydrolase YP_002406456.1 459740 R 585057 CDS YP_002406457.1 218698828 7153230 460699..460959 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99451883; Product type pf : putative factor; antitoxin of YafQ-DinJ toxin-antitoxin system 460959 dinJ 7153230 dinJ Escherichia coli IAI39 antitoxin of YafQ-DinJ toxin-antitoxin system YP_002406457.1 460699 D 585057 CDS YP_002406458.1 218698829 7151142 460962..461210 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15009896; Product type f : factor; toxin of the YafQ-DinJ toxin-antitoxin system 461210 yafQ 7151142 yafQ Escherichia coli IAI39 toxin of the YafQ-DinJ toxin-antitoxin system YP_002406458.1 460962 D 585057 CDS YP_002406459.1 218698830 7153233 461272..461574 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS600 461574 insM 7153233 insM Escherichia coli IAI39 transposase ORF A, IS600 YP_002406459.1 461272 D 585057 CDS YP_002406460.1 218698831 7151823 461610..462428 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 462428 7151823 ECIAI39_0427 Escherichia coli IAI39 transposase ORF B, IS600 YP_002406460.1 461610 D 585057 CDS YP_002406461.1 218698832 7149557 462663..463403 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 463403 yafK 7149557 yafK Escherichia coli IAI39 hypothetical protein YP_002406461.1 462663 D 585057 CDS YP_002406462.1 218698833 7153229 complement(463374..464141) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutamine amidotransferases class-II 464141 yafJ 7153229 yafJ Escherichia coli IAI39 putative glutamine amidotransferases class-II YP_002406462.1 463374 R 585057 CDS YP_002406463.1 218698834 7153228 complement(464246..464824) 1 NC_011750.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 464824 gmhA 7153228 gmhA Escherichia coli IAI39 phosphoheptose isomerase YP_002406463.1 464246 R 585057 CDS YP_002406464.1 218698835 7151956 465064..467508 1 NC_011750.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase 467508 fadE 7151956 fadE Escherichia coli IAI39 acyl-CoA dehydrogenase YP_002406464.1 465064 D 585057 CDS YP_002406465.1 218698836 7151275 complement(467551..468024) 1 NC_011750.1 inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 468024 ivy 7151275 ivy Escherichia coli IAI39 C-lysozyme inhibitor YP_002406465.1 467551 R 585057 CDS YP_002406466.1 218698837 7151868 468178..468948 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8526497; Product type pe : putative enzyme; hypothetical protein 468948 yafV 7151868 yafV Escherichia coli IAI39 hypothetical protein YP_002406466.1 468178 D 585057 CDS YP_002406467.1 218698838 7150635 complement(469256..469987) 1 NC_011750.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 469987 dnaQ 7150635 dnaQ Escherichia coli IAI39 DNA polymerase III subunit epsilon YP_002406467.1 469256 R 585057 CDS YP_002406468.1 218698839 7151161 470052..470519 1 NC_011750.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 470519 rnhA 7151161 rnhA Escherichia coli IAI39 ribonuclease H YP_002406468.1 470052 D 585057 CDS YP_002406469.1 218698840 7152658 complement(470516..471238) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase 471238 yafS 7152658 yafS Escherichia coli IAI39 putative S-adenosyl-L-methionine-dependent methyltransferase YP_002406469.1 470516 R 585057 CDS YP_002406470.1 218698841 7153234 471272..472027 1 NC_011750.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase 472027 gloB 7153234 gloB Escherichia coli IAI39 hydroxyacylglutathione hydrolase YP_002406470.1 471272 D 585057 CDS YP_002406471.1 218698842 7151535 472099..473457 1 NC_011750.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D 473457 mltD 7151535 mltD Escherichia coli IAI39 membrane-bound lytic murein transglycosylase D YP_002406471.1 472099 D 585057 CDS YP_002406472.1 218698843 7152092 complement(473506..474276) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase 474276 yafE 7152092 yafE Escherichia coli IAI39 putative S-adenosyl-L-methionine-dependent methyltransferase YP_002406472.1 473506 R 585057 CDS YP_002406473.1 218698844 7153227 complement(474353..475153) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1663890; hypothetical protein 475153 yafD 7153227 yafD Escherichia coli IAI39 hypothetical protein YP_002406473.1 474353 R 585057 CDS YP_002406474.1 218698845 7153226 475394..476308 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 476308 yafC 7153226 yafC Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002406474.1 475394 D 585057 CDS YP_002406475.1 218698846 7153225 complement(476305..477108) 1 NC_011750.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 477108 dkgB 7153225 dkgB Escherichia coli IAI39 2,5-diketo-D-gluconate reductase B YP_002406475.1 476305 R 585057 CDS YP_002406476.1 218698847 7149778 complement(482861..483433) 1 NC_011750.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 483433 gmhB 7149778 gmhB Escherichia coli IAI39 D,D-heptose 1,7-bisphosphate phosphatase YP_002406476.1 482861 R 585057 CDS YP_002406477.1 218698848 7151563 483621..484652 1 NC_011750.1 part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit 484652 metN 7151563 metN Escherichia coli IAI39 DL-methionine transporter ATP-binding subunit YP_002406477.1 483621 D 585057 CDS YP_002406478.1 218698849 7152061 484645..485298 1 NC_011750.1 part of the MetNIQ methionine uptake system; DL-methionine transporter permease subunit 485298 metI 7152061 metI Escherichia coli IAI39 DL-methionine transporter permease subunit YP_002406478.1 484645 D 585057 CDS YP_002406479.1 218698850 7152057 485338..486153 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12169620, 12218041, 12819857, 1459951; Product type t : transporter; DL-methionine transporter substrate-binding subunit 486153 metQ 7152057 metQ Escherichia coli IAI39 DL-methionine transporter substrate-binding subunit YP_002406479.1 485338 D 585057 CDS YP_002406480.1 218698851 7152062 486271..486675 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 93094132; Product type pr : putative regulator; outer membrane lipoprotein 486675 rcsF 7152062 rcsF Escherichia coli IAI39 outer membrane lipoprotein YP_002406480.1 486271 D 585057 CDS YP_002406481.1 218698852 7152581 486672..487379 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 487379 yaeB 7152581 yaeB Escherichia coli IAI39 hypothetical protein YP_002406481.1 486672 D 585057 CDS YP_002406482.1 218698853 7153216 487490..489208 1 NC_011750.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 489208 proS 7153216 proS Escherichia coli IAI39 prolyl-tRNA synthetase YP_002406482.1 487490 D 585057 CDS YP_002406483.1 218698854 7152488 complement(489304..489744) 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 489744 7152488 ECIAI39_0450 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002406483.1 489304 R 585057 CDS YP_002406484.1 218698855 7150519 complement(489873..491396) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9353259, 10413481; Product type e : enzyme; Group II intron-encoded reverse transcriptase/maturase 491396 7150519 ECIAI39_0451 Escherichia coli IAI39 Group II intron-encoded reverse transcriptase/maturase YP_002406484.1 489873 R 585057 CDS YP_002406485.1 218698856 7149560 complement(492440..492787) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS3 family 492787 7149560 ECIAI39_0453 Escherichia coli IAI39 transposase ORF A, IS3 family YP_002406485.1 492440 R 585057 CDS YP_002406486.1 218698857 7149561 492798..493616 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 493616 yaeF 7149561 yaeF Escherichia coli IAI39 hypothetical protein YP_002406486.1 492798 D 585057 CDS YP_002406487.1 218698858 7153217 complement(493646..494356) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11830644, 95362641, 95362642; Product type lp : lipoprotein; lipoprotein involved with copper homeostasis and adhesion 494356 nlpE 7153217 nlpE Escherichia coli IAI39 lipoprotein involved with copper homeostasis and adhesion YP_002406487.1 493646 R 585057 CDS YP_002406488.1 218698859 7152237 complement(494370..494792) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; peptidyl-tRNA hydrolase domain-containing protein 494792 yaeJ 7152237 yaeJ Escherichia coli IAI39 peptidyl-tRNA hydrolase domain-containing protein YP_002406488.1 494370 R 585057 CDS YP_002406489.1 218698860 7153219 complement(494789..495334) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 495334 yaeQ 7153219 yaeQ Escherichia coli IAI39 hypothetical protein YP_002406489.1 494789 R 585057 CDS YP_002406490.1 218698861 7153222 495500..495700 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 495700 yaeP 7153222 yaeP Escherichia coli IAI39 hypothetical protein YP_002406490.1 495500 D 585057 CDS YP_002406491.1 218698862 7153221 495693..495947 1 NC_011750.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator 495947 rof 7153221 rof Escherichia coli IAI39 Rho-binding antiterminator YP_002406491.1 495693 D 585057 CDS YP_002406492.1 218698863 7152665 496017..496547 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 496547 7152665 ECIAI39_0460 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002406492.1 496017 D 585057 CDS YP_002406493.1 218698864 7149562 496652..497374 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 497374 7149562 ECIAI39_0461 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002406493.1 496652 D 585057 CDS YP_002406494.1 218698865 7149563 complement(497539..498318) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative permease of an ABC transporter 498318 ybbM 7149563 ybbM Escherichia coli IAI39 putative permease of an ABC transporter YP_002406494.1 497539 R 585057 CDS YP_002406495.1 218698866 7153296 complement(498305..498982) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein YbbL 498982 ybbL 7153296 ybbL Escherichia coli IAI39 putative ABC transporter ATP-binding protein YbbL YP_002406495.1 498305 R 585057 CDS YP_002406496.1 218698867 7153295 499128..500045 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative protease, membrane anchored 500045 ybbK 7153295 ybbK Escherichia coli IAI39 putative protease, membrane anchored YP_002406496.1 499128 D 585057 CDS YP_002406497.1 218698868 7153294 500045..500500 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 500500 ybbJ 7153294 ybbJ Escherichia coli IAI39 hypothetical protein YP_002406497.1 500045 D 585057 CDS YP_002406498.1 218698869 7153293 complement(500603..500965) 1 NC_011750.1 hypothetical protein 500965 7153293 ECIAI39_0466 Escherichia coli IAI39 hypothetical protein YP_002406498.1 500603 R 585057 CDS YP_002406499.1 218698870 7149564 501331..502347 1 NC_011750.1 hypothetical protein 502347 7149564 ECIAI39_0467 Escherichia coli IAI39 hypothetical protein YP_002406499.1 501331 D 585057 CDS YP_002406500.1 218698871 7149565 502401..502823 1 NC_011750.1 putative lipoprotein 502823 7149565 ECIAI39_0468 Escherichia coli IAI39 putative lipoprotein YP_002406500.1 502401 D 585057 CDS YP_002406501.1 218698872 7149566 502820..503023 1 NC_011750.1 hypothetical protein 503023 7149566 ECIAI39_0469 Escherichia coli IAI39 hypothetical protein YP_002406501.1 502820 D 585057 CDS YP_002406502.1 218698873 7149567 503142..504470 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element 504470 insG 7149567 insG Escherichia coli IAI39 putative IS4 transposase; KpLE2 phage-like element YP_002406502.1 503142 D 585057 CDS YP_002406503.1 218698874 7151808 complement(504459..504872) 1 NC_011750.1 activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR 504872 cueR 7151808 cueR Escherichia coli IAI39 DNA-binding transcriptional regulator CueR YP_002406503.1 504459 R 585057 CDS YP_002406504.1 218698875 7152852 complement(505033..505536) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 505536 insB 7152852 insB Escherichia coli IAI39 IS1 transposase InsAB' YP_002406504.1 505033 R 585057 CDS YP_002406505.1 218698876 7151792 complement(505455..505730) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 505730 insA 7151792 insA Escherichia coli IAI39 IS1 repressor protein InsA YP_002406505.1 505455 R 585057 CDS YP_002406506.1 218698877 7151781 505611..507029 1 NC_011750.1 Plays a crucial role on both purine and pyrimidine metabolism; allantoinase 507029 allB 7151781 allB Escherichia coli IAI39 allantoinase YP_002406506.1 505611 D 585057 CDS YP_002406507.1 218698878 7150715 507086..508387 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative purine permease YbbY 508387 ybbY 7150715 ybbY Escherichia coli IAI39 putative purine permease YbbY YP_002406507.1 507086 D 585057 CDS YP_002406508.1 218698879 7153297 508409..509554 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20069628; Product type e : enzyme; glycerate kinase II 509554 glxK 7153297 glxK Escherichia coli IAI39 glycerate kinase II YP_002406508.1 508409 D 585057 CDS YP_002406509.1 218698880 7151558 complement(509684..510469) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 510469 ylbA 7151558 ylbA Escherichia coli IAI39 hypothetical protein YP_002406509.1 509684 R 585057 CDS YP_002406510.1 218698881 7154366 complement(510480..511715) 1 NC_011750.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase 511715 allC 7154366 allC Escherichia coli IAI39 allantoate amidohydrolase YP_002406510.1 510480 R 585057 CDS YP_002406511.1 218698882 7150716 complement(511737..512786) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12460564, 20069628, 69151449; Product type e : enzyme; ureidoglycolate dehydrogenase 512786 allD 7150716 allD Escherichia coli IAI39 ureidoglycolate dehydrogenase YP_002406511.1 511737 R 585057 CDS YP_002406512.1 218698883 7150717 513104..514771 1 NC_011750.1 multicopy suppressor of dominant negative ftsH mutations; membrane protein FdrA 514771 fdrA 7150717 fdrA Escherichia coli IAI39 membrane protein FdrA YP_002406512.1 513104 D 585057 CDS YP_002406513.1 218698884 7151292 514781..516040 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 516040 ylbE 7151292 ylbE Escherichia coli IAI39 hypothetical protein YP_002406513.1 514781 D 585057 CDS YP_002406514.1 218698885 7154367 516051..516866 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 516866 ylbF 7154367 ylbF Escherichia coli IAI39 hypothetical protein YP_002406514.1 516051 D 585057 CDS YP_002406515.1 218698886 7154368 516863..517756 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2464576, 2644189, 7920643, 7940673, 7984428; Product type pe : putative enzyme; carbamate kinase 517756 ybcF 7154368 ybcF Escherichia coli IAI39 carbamate kinase YP_002406515.1 516863 D 585057 CDS YP_002406516.1 218698887 7153298 complement(517989..519056) 1 NC_011750.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 519056 purK 7153298 purK Escherichia coli IAI39 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_002406516.1 517989 R 585057 CDS YP_002406517.1 218698888 7152530 complement(519053..519562) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10074353, 8117684, 89123018, 89123019, 92287929, 10574791; Product type e : enzyme; N5-carboxyaminoimidazole ribonucleotide mutase 519562 purE 7152530 purE Escherichia coli IAI39 N5-carboxyaminoimidazole ribonucleotide mutase YP_002406517.1 519053 R 585057 CDS YP_002406518.1 218698889 7152527 complement(519680..520402) 1 NC_011750.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 520402 lpxH 7152527 lpxH Escherichia coli IAI39 UDP-2,3-diacylglucosamine hydrolase YP_002406518.1 519680 R 585057 CDS YP_002406519.1 218698890 7151969 complement(520405..520899) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90272647, 91175755, 1606970, 1864365, 8601841, 9298646, 9600841; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase B 520899 ppiB 7151969 ppiB Escherichia coli IAI39 peptidyl-prolyl cis-trans isomerase B YP_002406519.1 520405 R 585057 CDS YP_002406520.1 218698891 7152461 521128..521454 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 521454 7152461 ECIAI39_0489 Escherichia coli IAI39 transposase ORF A, IS629 YP_002406520.1 521128 D 585057 CDS YP_002406521.1 218698892 7149568 521451..522341 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 522341 7149568 ECIAI39_0490 Escherichia coli IAI39 transposase ORF B, IS629 YP_002406521.1 521451 D 585057 CDS YP_002406522.1 218698893 7149569 522384..523769 1 NC_011750.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 523769 cysS 7149569 cysS Escherichia coli IAI39 cysteinyl-tRNA synthetase YP_002406522.1 522384 D 585057 CDS YP_002406523.1 218698894 7151069 complement(523805..524326) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 524326 ybcI 7151069 ybcI Escherichia coli IAI39 hypothetical protein YP_002406523.1 523805 R 585057 CDS YP_002406524.1 218698895 7153300 complement(524434..524646) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12837795, 1748668, 7567469; Product type pr : putative regulator; hypothetical protein 524646 ybcJ 7153300 ybcJ Escherichia coli IAI39 hypothetical protein YP_002406524.1 524434 R 585057 CDS YP_002406525.1 218698896 7153301 complement(524648..525514) 1 NC_011750.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 525514 folD 7153301 folD Escherichia coli IAI39 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_002406525.1 524648 R 585057 CDS YP_002406526.1 218698897 7151400 525986..526528 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2890624; Product type ps : putative structure; putative fimbrial-like adhesin protein 526528 sfmA 7151400 sfmA Escherichia coli IAI39 putative fimbrial-like adhesin protein YP_002406526.1 525986 D 585057 CDS YP_002406527.1 218698898 7152837 526747..527439 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15372038, 2553674; Product type f : factor; pilin chaperone, periplasmic 527439 sfmC 7152837 sfmC Escherichia coli IAI39 pilin chaperone, periplasmic YP_002406527.1 526747 D 585057 CDS YP_002406528.1 218698899 7152838 527470..530079 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1970114; Product type pf : putative factor; putative outer membrane export usher protein 530079 sfmD 7152838 sfmD Escherichia coli IAI39 putative outer membrane export usher protein YP_002406528.1 527470 D 585057 CDS YP_002406529.1 218698900 7152839 530122..531099 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein 531099 sfmH 7152839 sfmH Escherichia coli IAI39 putative fimbrial-like adhesin protein YP_002406529.1 530122 D 585057 CDS YP_002406530.1 218698901 7152841 531201..531626 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2890624; Product type ps : putative structure; putative fimbrial protein 531626 sfmF 7152841 sfmF Escherichia coli IAI39 putative fimbrial protein YP_002406530.1 531201 D 585057 CDS YP_002406531.1 218698902 7152840 complement(531629..532261) 1 NC_011750.1 activates the production of the major fimbrae protein FimA; transcriptional regulator FimZ 532261 fimZ 7152840 fimZ Escherichia coli IAI39 transcriptional regulator FimZ YP_002406531.1 531629 R 585057 CDS YP_002406532.1 218698903 7151833 complement(532898..533788) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 533788 7151833 ECIAI39_0502 Escherichia coli IAI39 transposase ORF B, IS629 YP_002406532.1 532898 R 585057 CDS YP_002406533.1 218698904 7149570 complement(533785..534111) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 534111 7149570 ECIAI39_0503 Escherichia coli IAI39 transposase ORF A, IS629 YP_002406533.1 533785 R 585057 CDS YP_002406534.1 218698905 7149571 534073..535077 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative integrase of prophage 535077 7149571 ECIAI39_0504 Escherichia coli IAI39 putative integrase of prophage YP_002406534.1 534073 D 585057 CDS YP_002406535.1 218698906 7149572 535070..535306 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA binding protein from phage origin 535306 7149572 ECIAI39_0505 Escherichia coli IAI39 putative DNA binding protein from phage origin YP_002406535.1 535070 D 585057 CDS YP_002406536.1 218698907 7149573 536225..537139 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 537139 7149573 ECIAI39_0507 Escherichia coli IAI39 hypothetical protein YP_002406536.1 536225 D 585057 CDS YP_002406537.1 218698908 7149574 537132..537356 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 537356 7149574 ECIAI39_0508 Escherichia coli IAI39 hypothetical protein YP_002406537.1 537132 D 585057 CDS YP_002406538.1 218698909 7149575 537359..537646 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 537646 7149575 ECIAI39_0509 Escherichia coli IAI39 hypothetical protein YP_002406538.1 537359 D 585057 CDS YP_002406539.1 218698910 7149576 537826..539463 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA primase from prophage 539463 7149576 ECIAI39_0510 Escherichia coli IAI39 putative DNA primase from prophage YP_002406539.1 537826 D 585057 CDS YP_002406540.1 218698911 7149577 539751..539996 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 539996 7149577 ECIAI39_0511 Escherichia coli IAI39 hypothetical protein YP_002406540.1 539751 D 585057 CDS YP_002406541.1 218698912 7149578 539993..540442 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative single-stranded DNA-binding protein 540442 7149578 ECIAI39_0512 Escherichia coli IAI39 putative single-stranded DNA-binding protein YP_002406541.1 539993 D 585057 CDS YP_002406542.1 218698913 7149579 540486..541700 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative major head protein from prophage 541700 7149579 ECIAI39_0513 Escherichia coli IAI39 putative major head protein from prophage YP_002406542.1 540486 D 585057 CDS YP_002406543.1 218698914 7149580 541710..542051 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head decoration protein from prophage 542051 7149580 ECIAI39_0514 Escherichia coli IAI39 putative head decoration protein from prophage YP_002406543.1 541710 D 585057 CDS YP_002406544.1 218698915 7149581 542063..542446 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 542446 7149581 ECIAI39_0515 Escherichia coli IAI39 hypothetical protein YP_002406544.1 542063 D 585057 CDS YP_002406545.1 218698916 7149582 complement(543045..544187) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 544187 7149582 ECIAI39_0516 Escherichia coli IAI39 hypothetical protein YP_002406545.1 543045 R 585057 CDS YP_002406546.1 218698917 7149583 544409..545185 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major head protein 545185 E 7149583 E Escherichia coli IAI39 major head protein YP_002406546.1 544409 D 585057 CDS YP_002406547.1 218698918 7151191 545188..545625 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; DNA packaging protein from bacteriophage origin 545625 fI 7151191 fI Escherichia coli IAI39 DNA packaging protein from bacteriophage origin YP_002406547.1 545188 D 585057 CDS YP_002406548.1 218698919 7151321 545637..545990 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin; tail attachment protein from bacteriophage origin 545990 fII 7151321 fII Escherichia coli IAI39 tail attachment protein from bacteriophage origin YP_002406548.1 545637 D 585057 CDS YP_002406549.1 218698920 7151326 546002..546580 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein Z (GpZ) 546580 7151326 ECIAI39_0520 Escherichia coli IAI39 minor tail protein Z (GpZ) YP_002406549.1 546002 D 585057 CDS YP_002406550.1 218698921 7149584 546577..546972 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein U 546972 7149584 ECIAI39_0521 Escherichia coli IAI39 minor tail protein U YP_002406550.1 546577 D 585057 CDS YP_002406551.1 218698922 7149585 546950..547720 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail protein V 547720 7149585 ECIAI39_0522 Escherichia coli IAI39 major tail protein V YP_002406551.1 546950 D 585057 CDS YP_002406552.1 218698923 7149586 547736..548158 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein G 548158 7149586 ECIAI39_0523 Escherichia coli IAI39 minor tail protein G YP_002406552.1 547736 D 585057 CDS YP_002406553.1 218698924 7149587 548140..548598 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein T 548598 7149587 ECIAI39_0524 Escherichia coli IAI39 minor tail protein T YP_002406553.1 548140 D 585057 CDS YP_002406554.1 218698925 7149588 548567..551113 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein H 551113 7149588 ECIAI39_0525 Escherichia coli IAI39 minor tail protein H YP_002406554.1 548567 D 585057 CDS YP_002406555.1 218698926 7149589 551110..551439 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein M 551439 7149589 ECIAI39_0526 Escherichia coli IAI39 minor tail protein M YP_002406555.1 551110 D 585057 CDS YP_002406556.1 218698927 7149590 551439..552137 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein L 552137 7149590 ECIAI39_0527 Escherichia coli IAI39 minor tail protein L YP_002406556.1 551439 D 585057 CDS YP_002406557.1 218698928 7149591 552143..552886 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber component K of prophage 552886 7149591 ECIAI39_0528 Escherichia coli IAI39 putative tail fiber component K of prophage YP_002406557.1 552143 D 585057 CDS YP_002406558.1 218698929 7149592 552784..553455 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein I 553455 7149592 ECIAI39_0529 Escherichia coli IAI39 tail assembly protein I YP_002406558.1 552784 D 585057 CDS YP_002406559.1 218698930 7149593 553516..556995 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J of prophage 556995 7149593 ECIAI39_0530 Escherichia coli IAI39 Host specificity protein J of prophage YP_002406559.1 553516 D 585057 CDS YP_002406560.1 218698931 7149594 557063..557662 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Lom-like outer membrane protein of prophage 557662 7149594 ECIAI39_0531 Escherichia coli IAI39 putative Lom-like outer membrane protein of prophage YP_002406560.1 557063 D 585057 CDS YP_002406561.1 218698932 7149595 557721..560126 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative prophage side tail fiber protein 560126 7149595 ECIAI39_0532 Escherichia coli IAI39 putative prophage side tail fiber protein YP_002406561.1 557721 D 585057 CDS YP_002406562.1 218698933 7149596 560123..560404 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 560404 7149596 ECIAI39_0533 Escherichia coli IAI39 hypothetical protein YP_002406562.1 560123 D 585057 CDS YP_002406563.1 218698934 7149597 560414..561118 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 561118 7149597 ECIAI39_0534 Escherichia coli IAI39 hypothetical protein YP_002406563.1 560414 D 585057 CDS YP_002406564.1 218698935 7149598 561129..561422 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 561422 7149598 ECIAI39_0535 Escherichia coli IAI39 hypothetical protein YP_002406564.1 561129 D 585057 CDS YP_002406565.1 218698936 7149599 complement(561616..562200) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative AdoMet-dependent methyltransferase; DLP12 prophage 562200 ybcY 7149599 ybcY Escherichia coli IAI39 putative AdoMet-dependent methyltransferase; DLP12 prophage YP_002406565.1 561616 R 585057 CDS YP_002406566.1 218698937 7154369 complement(562823..564307) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative protease 564307 7154369 ECIAI39_0538 Escherichia coli IAI39 putative protease YP_002406566.1 562823 R 585057 CDS YP_002406567.1 218698938 7149600 complement(564494..565447) 1 NC_011750.1 outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA; outer membrane protease 565447 ompT 7149600 ompT Escherichia coli IAI39 outer membrane protease YP_002406567.1 564494 R 585057 CDS YP_002406568.1 218698939 7152297 complement(565959..566720) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6317653, 2536924; Product type r : regulator; DNA-binding transcriptional activator of porin biosynthesis 566720 envY 7152297 envY Escherichia coli IAI39 DNA-binding transcriptional activator of porin biosynthesis YP_002406568.1 565959 R 585057 CDS YP_002406569.1 218698940 7151230 complement(566903..567793) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 567793 ybcH 7151230 ybcH Escherichia coli IAI39 hypothetical protein YP_002406569.1 566903 R 585057 CDS YP_002406570.1 218698941 7153299 complement(567794..570766) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89359086, 94042873, 94042874; Product type m : membrane component; bacteriophage N4 receptor, outer membrane subunit 570766 nfrA 7153299 nfrA Escherichia coli IAI39 bacteriophage N4 receptor, outer membrane subunit YP_002406570.1 567794 R 585057 CDS YP_002406571.1 218698942 7152218 complement(573140..574582) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 11283292, 11399769; Product type r : regulator; sensor kinase CusS 574582 cusS 7152218 cusS Escherichia coli IAI39 sensor kinase CusS YP_002406571.1 573140 R 585057 CDS YP_002406572.1 218698943 7151033 complement(574572..575255) 1 NC_011750.1 response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR 575255 cusR 7151033 cusR Escherichia coli IAI39 DNA-binding transcriptional activator CusR YP_002406572.1 574572 R 585057 CDS YP_002406573.1 218698944 7151032 575412..576794 1 NC_011750.1 with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 576794 cusC 7151032 cusC Escherichia coli IAI39 copper/silver efflux system outer membrane protein CusC YP_002406573.1 575412 D 585057 CDS YP_002406574.1 218698945 7151030 576818..577150 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 21125583, 11283292, 11399769, 12813074; Product type f : factor; periplasmic copper-binding protein 577150 cusF 7151030 cusF Escherichia coli IAI39 periplasmic copper-binding protein YP_002406574.1 576818 D 585057 CDS YP_002406575.1 218698946 7151031 577166..578389 1 NC_011750.1 with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB 578389 cusB 7151031 cusB Escherichia coli IAI39 copper/silver efflux system membrane fusion protein CusB YP_002406575.1 577166 D 585057 CDS YP_002406576.1 218698947 7151029 578401..581544 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 21125583, 21178899, 21450803, 11399769, 12813074, 1711024, 7984428; Product type t : transporter; copper/silver efflux system, membrane component 581544 cusA 7151029 cusA Escherichia coli IAI39 copper/silver efflux system, membrane component YP_002406576.1 578401 D 585057 CDS YP_002406577.1 218698948 7151028 581646..583022 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91267923, 94042931, 8626334; Product type t : transporter; phenylalanine transporter 583022 pheP 7151028 pheP Escherichia coli IAI39 phenylalanine transporter YP_002406577.1 581646 D 585057 CDS YP_002406578.1 218698949 7152391 complement(583103..584350) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative membrane protein; putative channel 584350 ybdG 7152391 ybdG Escherichia coli IAI39 putative membrane protein; putative channel YP_002406578.1 583103 R 585057 CDS YP_002406579.1 218698950 7153308 complement(584458..585111) 1 NC_011750.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase 585111 nfnB 7153308 nfnB Escherichia coli IAI39 dihydropteridine reductase YP_002406579.1 584458 R 585057 CDS YP_002406580.1 218698951 7152214 complement(585190..585558) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 585558 ybdF 7152214 ybdF Escherichia coli IAI39 hypothetical protein YP_002406580.1 585190 R 585057 CDS YP_002406581.1 218698952 7153307 complement(585638..585886) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 585886 ybdJ 7153307 ybdJ Escherichia coli IAI39 hypothetical protein YP_002406581.1 585638 R 585057 CDS YP_002406582.1 218698953 7153310 complement(585952..587070) 1 NC_011750.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase 587070 ybdK 7153310 ybdK Escherichia coli IAI39 carboxylate-amine ligase YP_002406582.1 585952 R 585057 CDS YP_002406583.1 218698954 7153311 complement(587796..588425) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89313305, 90132534, 91035252, 8939709, 9214294; Product type e : enzyme; phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex 588425 entD 7153311 entD Escherichia coli IAI39 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex YP_002406583.1 587796 R 585057 CDS YP_002406584.1 218698955 7151225 588579..589109 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 589109 7151225 ECIAI39_0558 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002406584.1 588579 D 585057 CDS YP_002406585.1 218698956 7149601 589214..589936 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 589936 7149601 ECIAI39_0559 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002406585.1 589214 D 585057 CDS YP_002406586.1 218698957 7149602 complement(590026..592266) 1 NC_011750.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA 592266 fepA 7149602 fepA Escherichia coli IAI39 outer membrane receptor FepA YP_002406586.1 590026 R 585057 CDS YP_002406587.1 218698958 7151303 592587..593711 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92291125, 94198561, 2974033; Product type e : enzyme; enterobactin/ferric enterobactin esterase 593711 fes 7151303 fes Escherichia coli IAI39 enterobactin/ferric enterobactin esterase YP_002406587.1 592587 D 585057 CDS YP_002406588.1 218698959 7151309 593714..593932 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 593932 ybdZ 7151309 ybdZ Escherichia coli IAI39 hypothetical protein YP_002406588.1 593714 D 585057 CDS YP_002406589.1 218698960 7153314 593929..597810 1 NC_011750.1 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 597810 entF 7153314 entF Escherichia coli IAI39 enterobactin synthase subunit F YP_002406589.1 593929 D 585057 CDS YP_002406590.1 218698961 7151227 598025..599158 1 NC_011750.1 part of the ferric enterobactin transport system; necessary for enetrobactin uptake; ferric enterobactin transport protein FepE 599158 fepE 7151227 fepE Escherichia coli IAI39 ferric enterobactin transport protein FepE YP_002406590.1 598025 D 585057 CDS YP_002406591.1 218698962 7151307 complement(599155..599970) 1 NC_011750.1 with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein 599970 fepC 7151307 fepC Escherichia coli IAI39 iron-enterobactin transporter ATP-binding protein YP_002406591.1 599155 R 585057 CDS YP_002406592.1 218698963 7151305 complement(599967..600959) 1 NC_011750.1 with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease 600959 fepG 7151305 fepG Escherichia coli IAI39 iron-enterobactin transporter permease YP_002406592.1 599967 R 585057 CDS YP_002406593.1 218698964 7151308 complement(600956..601960) 1 NC_011750.1 with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein 601960 fepD 7151308 fepD Escherichia coli IAI39 iron-enterobactin transporter membrane protein YP_002406593.1 600956 R 585057 CDS YP_002406594.1 218698965 7151306 602071..603321 1 NC_011750.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 603321 ybdA 7151306 ybdA Escherichia coli IAI39 enterobactin exporter EntS YP_002406594.1 602071 D 585057 CDS YP_002406595.1 218698966 7153304 complement(603325..604281) 1 NC_011750.1 with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein 604281 fepB 7153304 fepB Escherichia coli IAI39 iron-enterobactin transporter periplasmic binding protein YP_002406595.1 603325 R 585057 CDS YP_002406596.1 218698967 7151304 604470..605645 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89123153, 90165423, 90241936, 2110093, 2139473; Product type e : enzyme; isochorismate synthase 1 605645 entC 7151304 entC Escherichia coli IAI39 isochorismate synthase 1 YP_002406596.1 604470 D 585057 CDS YP_002406597.1 218698968 7151224 605655..607265 1 NC_011750.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 607265 entE 7151224 entE Escherichia coli IAI39 enterobactin synthase subunit E YP_002406597.1 605655 D 585057 CDS YP_002406598.1 218698969 7151226 607279..608136 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20183918, 90241937, 91035252, 9485415, 97361959, 2521621, 2521622; Product type e : enzyme; isochorismatase 608136 entB 7151226 entB Escherichia coli IAI39 isochorismatase YP_002406598.1 607279 D 585057 CDS YP_002406599.1 218698970 7151223 608136..608882 1 NC_011750.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 608882 entA 7151223 entA Escherichia coli IAI39 2,3-dihydroxybenzoate-2,3-dehydrogenase YP_002406599.1 608136 D 585057 CDS YP_002406600.1 218698971 7151222 608885..609298 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2521621, 2521622, 15808744; Product type pe : putative enzyme; hypothetical protein 609298 ybdB 7151222 ybdB Escherichia coli IAI39 hypothetical protein YP_002406600.1 608885 D 585057 CDS YP_002406601.1 218698972 7153305 609479..611584 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91162636, 2521622; Product type pf : putative factor; carbon starvation protein 611584 cstA 7153305 cstA Escherichia coli IAI39 carbon starvation protein YP_002406601.1 609479 D 585057 CDS YP_002406602.1 218698973 7151025 611697..611894 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 611894 ybdD 7151025 ybdD Escherichia coli IAI39 hypothetical protein YP_002406602.1 611697 D 585057 CDS YP_002406603.1 218698974 7153306 complement(611904..612992) 1 NC_011750.1 member of the iron-containing alcohol dehydrogenase family; unknown function; hypothetical protein 612992 ybdH 7153306 ybdH Escherichia coli IAI39 hypothetical protein YP_002406603.1 611904 R 585057 CDS YP_002406604.1 218698975 7153309 613101..614261 1 NC_011750.1 catalyzes the transfer of an amino moiety; putative aminotransferase 614261 ybdL 7153309 ybdL Escherichia coli IAI39 putative aminotransferase YP_002406604.1 613101 D 585057 CDS YP_002406605.1 218698976 7153312 complement(614262..614891) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator 614891 ibrB 7153312 ibrB Escherichia coli IAI39 immunoglobulin-binding regulator YP_002406605.1 614262 R 585057 CDS YP_002406606.1 218698977 7151748 complement(614864..616084) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator 616084 ibrA 7151748 ibrA Escherichia coli IAI39 immunoglobulin-binding regulator YP_002406606.1 614864 R 585057 CDS YP_002406607.1 218698978 7151746 complement(616231..617169) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative LysR-type DNA-binding transcriptional regulator 617169 ybdO 7151746 ybdO Escherichia coli IAI39 putative LysR-type DNA-binding transcriptional regulator YP_002406607.1 616231 R 585057 CDS YP_002406608.1 218698979 7153313 complement(617338..618084) 1 NC_011750.1 Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase 618084 dsbG 7153313 dsbG Escherichia coli IAI39 disulfide isomerase/thiol-disulfide oxidase YP_002406608.1 617338 R 585057 CDS YP_002406609.1 218698980 7151175 618456..619019 1 NC_011750.1 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase subunit C 619019 ahpC 7151175 ahpC Escherichia coli IAI39 alkyl hydroperoxide reductase subunit C YP_002406609.1 618456 D 585057 CDS YP_002406610.1 218698981 7150706 619148..620713 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89197774, 1592833; Product type e : enzyme; alkyl hydroperoxide reductase F52a subunit 620713 ahpF 7150706 ahpF Escherichia coli IAI39 alkyl hydroperoxide reductase F52a subunit YP_002406610.1 619148 D 585057 CDS YP_002406611.1 218698982 7150707 complement(620835..621263) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 12071968; Product type f : factor; universal stress protein UP12 621263 uspG 7150707 uspG Escherichia coli IAI39 universal stress protein UP12 YP_002406611.1 620835 R 585057 CDS YP_002406612.1 218698983 7153111 complement(621619..622029) 1 NC_011750.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator 622029 rnk 7153111 rnk Escherichia coli IAI39 nucleoside diphosphate kinase regulator YP_002406612.1 621619 R 585057 CDS YP_002406613.1 218698984 7152660 complement(622259..623065) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90151658, 90264307, 2253883, 8188249; Product type e : enzyme; ribonuclease I 623065 rna 7152660 rna Escherichia coli IAI39 ribonuclease I YP_002406613.1 622259 R 585057 CDS YP_002406614.1 218698985 7152651 complement(623179..624642) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9696764; Product type t : transporter; citrate:succinate antiporter 624642 citT 7152651 citT Escherichia coli IAI39 citrate:succinate antiporter YP_002406614.1 623179 R 585057 CDS YP_002406615.1 218698986 7150958 complement(624692..625570) 1 NC_011750.1 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase 625570 citG 7150958 citG Escherichia coli IAI39 triphosphoribosyl-dephospho-CoA synthase YP_002406615.1 624692 R 585057 CDS YP_002406616.1 218698987 7150957 complement(625545..626096) 1 NC_011750.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo- citrate lyase 626096 citX 7150957 citX Escherichia coli IAI39 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo- citrate lyase YP_002406616.1 625545 R 585057 CDS YP_002406617.1 218698988 7150959 complement(626100..627632) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase, citrate-ACP transferase subunit alpha 627632 citF 7150959 citF Escherichia coli IAI39 citrate lyase, citrate-ACP transferase subunit alpha YP_002406617.1 626100 R 585057 CDS YP_002406618.1 218698989 7150956 complement(627643..628551) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase, citryl-ACP lyase subunit beta 628551 citE 7150956 citE Escherichia coli IAI39 citrate lyase, citryl-ACP lyase subunit beta YP_002406618.1 627643 R 585057 CDS YP_002406619.1 218698990 7150955 complement(628548..628844) 1 NC_011750.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma 628844 citD 7150955 citD Escherichia coli IAI39 citrate lyase subunit gamma YP_002406619.1 628548 R 585057 CDS YP_002406620.1 218698991 7150954 complement(628859..629917) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase synthetase 629917 citC 7150954 citC Escherichia coli IAI39 citrate lyase synthetase YP_002406620.1 628859 R 585057 CDS YP_002406621.1 218698992 7150953 630296..631954 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11889485, 21885746, 9701802; Product type r : regulator; sensory histidine kinase in two-component regulatory system with citB 631954 citA 7150953 citA Escherichia coli IAI39 sensory histidine kinase in two-component regulatory system with citB YP_002406621.1 630296 D 585057 CDS YP_002406622.1 218698993 7150951 631923..632603 1 NC_011750.1 regulates the expression of citAB in citrate fermentation; two-component response regulator DpiA 632603 dpiA 7150951 dpiA Escherichia coli IAI39 two-component response regulator DpiA YP_002406622.1 631923 D 585057 CDS YP_002406623.1 218698994 7150952 complement(632644..634029) 1 NC_011750.1 responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC 634029 dcuC 7150952 dcuC Escherichia coli IAI39 C4-dicarboxylate transporter DcuC YP_002406623.1 632644 R 585057 CDS YP_002406624.1 218698995 7151097 634618..635178 1 NC_011750.1 catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 635178 pagP 7151097 pagP Escherichia coli IAI39 palmitoyl transferase YP_002406624.1 634618 D 585057 CDS YP_002406625.1 218698996 7150992 635353..635562 1 NC_011750.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 635562 cspE 7150992 cspE Escherichia coli IAI39 cold shock protein CspE YP_002406625.1 635353 D 585057 CDS YP_002406626.1 218698997 7151016 complement(635616..635999) 1 NC_011750.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 635999 crcB 7151016 crcB Escherichia coli IAI39 camphor resistance protein CrcB YP_002406626.1 635616 R 585057 CDS YP_002406627.1 218698998 7150993 636317..636880 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amidase 636880 ybeM 7150993 ybeM Escherichia coli IAI39 putative amidase YP_002406627.1 636317 D 585057 CDS YP_002406628.1 218698999 7153320 637009..637212 1 NC_011750.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein E 637212 tatE 7153320 tatE Escherichia coli IAI39 twin arginine translocase protein E YP_002406628.1 637009 D 585057 CDS YP_002406629.1 218699000 7152947 complement(637313..638278) 1 NC_011750.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 638278 lipA 7152947 lipA Escherichia coli IAI39 lipoyl synthase YP_002406629.1 637313 R 585057 CDS YP_002406630.1 218699001 7151938 complement(638487..639440) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12218038; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 639440 ybeF 7151938 ybeF Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002406630.1 638487 R 585057 CDS YP_002406631.1 218699002 7153318 complement(639699..640340) 1 NC_011750.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 640340 lipB 7153318 lipB Escherichia coli IAI39 lipoate-protein ligase B YP_002406631.1 639699 R 585057 CDS YP_002406632.1 218699003 7151939 complement(640441..640704) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8444795; hypothetical protein 640704 ybeD 7151939 ybeD Escherichia coli IAI39 hypothetical protein YP_002406632.1 640441 R 585057 CDS YP_002406633.1 218699004 7153317 complement(640814..642025) 1 NC_011750.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase fraction A 642025 dacA 7153317 dacA Escherichia coli IAI39 D-alanyl-D-alanine carboxypeptidase fraction A YP_002406633.1 640814 R 585057 CDS YP_002406634.1 218699005 7151076 complement(642165..643253) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88058785, 2644207; Product type lp : lipoprotein; rare lipoprotein A 643253 rlpA 7151076 rlpA Escherichia coli IAI39 rare lipoprotein A YP_002406634.1 642165 R 585057 CDS YP_002406635.1 218699006 7152639 complement(643264..644376) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89123070, 90036736, 91072213, 3316191; Product type cp : cell process; cell wall shape-determining protein 644376 mrdB 7152639 mrdB Escherichia coli IAI39 cell wall shape-determining protein YP_002406635.1 643264 R 585057 CDS YP_002406636.1 218699007 7152125 complement(644379..646280) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86196149, 87030266, 89174517, 2644207; Product type e : enzyme; penicillin-binding protein 2 646280 mrdA 7152125 mrdA Escherichia coli IAI39 penicillin-binding protein 2 YP_002406636.1 644379 R 585057 CDS YP_002406637.1 218699008 7152124 complement(646311..646778) 1 NC_011750.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 646778 ybeA 7152124 ybeA Escherichia coli IAI39 rRNA large subunit methyltransferase YP_002406637.1 646311 R 585057 CDS YP_002406638.1 218699009 7153315 complement(646782..647099) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 647099 ybeB 7153315 ybeB Escherichia coli IAI39 hypothetical protein YP_002406638.1 646782 R 585057 CDS YP_002406639.1 218699010 7153316 complement(647359..647970) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7929373; Product type pe : putative enzyme; putative phosphatase with phosphoglycerate mutase domain 647970 phpB 7153316 phpB Escherichia coli IAI39 putative phosphatase with phosphoglycerate mutase domain YP_002406639.1 647359 R 585057 CDS YP_002406640.1 218699011 7152418 complement(647994..648635) 1 NC_011750.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 648635 nadD 7152418 nadD Escherichia coli IAI39 nicotinic acid mononucleotide adenylyltransferase YP_002406640.1 647994 R 585057 CDS YP_002406641.1 218699012 7152168 complement(648637..649668) 1 NC_011750.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 649668 holA 7152168 holA Escherichia coli IAI39 DNA polymerase III subunit delta YP_002406641.1 648637 R 585057 CDS YP_002406642.1 218699013 7151667 complement(649668..650249) 1 NC_011750.1 rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB 650249 rlpB 7151667 rlpB Escherichia coli IAI39 LPS-assembly lipoprotein RlpB YP_002406642.1 649668 R 585057 CDS YP_002406643.1 218699014 7152640 complement(650264..652846) 1 NC_011750.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 652846 leuS 7152640 leuS Escherichia coli IAI39 leucyl-tRNA synthetase YP_002406643.1 650264 R 585057 CDS YP_002406644.1 218699015 7151930 653081..653563 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11373298, 12105207, 3320963, 7567469; hypothetical protein 653563 ybeL 7151930 ybeL Escherichia coli IAI39 hypothetical protein YP_002406644.1 653081 D 585057 CDS YP_002406645.1 218699016 7153319 complement(653608..654543) 1 NC_011750.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 654543 rihA 7153319 rihA Escherichia coli IAI39 ribonucleoside hydrolase 1 YP_002406645.1 653608 R 585057 CDS YP_002406646.1 218699017 7152631 complement(654661..655386) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate ABC transporter ATP-binding protein 655386 gltL 7152631 gltL Escherichia coli IAI39 glutamate and aspartate ABC transporter ATP-binding protein YP_002406646.1 654661 R 585057 CDS YP_002406647.1 218699018 7151554 complement(655386..656060) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate ABC transporter membrane protein 656060 gltK 7151554 gltK Escherichia coli IAI39 glutamate and aspartate ABC transporter membrane protein YP_002406647.1 655386 R 585057 CDS YP_002406648.1 218699019 7151553 complement(656060..656800) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate ABC transporter membrane protein 656800 gltJ 7151553 gltJ Escherichia coli IAI39 glutamate and aspartate ABC transporter membrane protein YP_002406648.1 656060 R 585057 CDS YP_002406649.1 218699020 7150520 complement(656970..657878) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1091636, 1091635, 10493123, 8740179, 10972807; Product type t : transporter; glutamate and aspartate transporter subunit 657878 gltI 7150520 gltI Escherichia coli IAI39 glutamate and aspartate transporter subunit YP_002406649.1 656970 R 585057 CDS YP_002406650.1 218699021 7151551 complement(658275..659813) 1 NC_011750.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 659813 lnt 7151551 lnt Escherichia coli IAI39 apolipoprotein N-acyltransferase YP_002406650.1 658275 R 585057 CDS YP_002406651.1 218699022 7151949 complement(659838..660716) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1779764; Product type pt : putative transporter; putative divalent ion export protein 660716 ybeX 7151949 ybeX Escherichia coli IAI39 putative divalent ion export protein YP_002406651.1 659838 R 585057 CDS YP_002406652.1 218699023 7153321 complement(660806..661273) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16511207; Product type pe : putative enzyme; putative metalloprotease 661273 ybeY 7153321 ybeY Escherichia coli IAI39 putative metalloprotease YP_002406652.1 660806 R 585057 CDS YP_002406653.1 218699024 7153322 complement(661270..662349) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12762842; Product type pe : putative enzyme; putative enzyme with nucleoside triphosphate hydrolase domain 662349 ybeZ 7153322 ybeZ Escherichia coli IAI39 putative enzyme with nucleoside triphosphate hydrolase domain YP_002406653.1 661270 R 585057 CDS YP_002406654.1 218699025 7153323 complement(662463..663887) 1 NC_011750.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 663887 miaB 7153323 miaB Escherichia coli IAI39 (dimethylallyl)adenosine tRNA methylthiotransferase YP_002406654.1 662463 R 585057 CDS YP_002406655.1 218699026 7152079 664033..665208 1 NC_011750.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 665208 ubiF 7152079 ubiF Escherichia coli IAI39 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase YP_002406655.1 664033 D 585057 CDS YP_002406656.1 218699027 7150624 666459..666896 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 666896 7150624 ECIAI39_0630 Escherichia coli IAI39 hypothetical protein YP_002406656.1 666459 D 585057 CDS YP_002406657.1 218699028 7149603 complement(666938..668602) 1 NC_011750.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B 668602 asnB 7149603 asnB Escherichia coli IAI39 asparagine synthetase B YP_002406657.1 666938 R 585057 CDS YP_002406658.1 218699029 7150803 complement(668859..669611) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16430214, 89343637; Product type e : enzyme; UMP phosphatase 669611 nagD 7150803 nagD Escherichia coli IAI39 UMP phosphatase YP_002406658.1 668859 R 585057 CDS YP_002406659.1 218699030 7152174 complement(669659..670879) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15066032, 90136533, 91171292, 92114782, 92356048, 2190615, 2668691, 7545108; Product type r : regulator; DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine 670879 nagC 7152174 nagC Escherichia coli IAI39 DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine YP_002406659.1 669659 R 585057 CDS YP_002406660.1 218699031 7152173 complement(670888..672036) 1 NC_011750.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 672036 nagA 7152173 nagA Escherichia coli IAI39 N-acetylglucosamine-6-phosphate deacetylase YP_002406660.1 670888 R 585057 CDS YP_002406661.1 218699032 7152171 complement(672096..672896) 1 NC_011750.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 672896 nagB 7152171 nagB Escherichia coli IAI39 glucosamine-6-phosphate deaminase YP_002406661.1 672096 R 585057 CDS YP_002406662.1 218699033 7152172 673285..675174 1 NC_011750.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunits IIABC 675174 nagE 7152172 nagE Escherichia coli IAI39 PTS system N-acetyl glucosamine specific transporter subunits IIABC YP_002406662.1 673285 D 585057 CDS YP_002406663.1 218699034 7152175 675377..677041 1 NC_011750.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 677041 glnS 7152175 glnS Escherichia coli IAI39 glutaminyl-tRNA synthetase YP_002406663.1 675377 D 585057 CDS YP_002406664.1 218699035 7151533 677483..678889 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2118530, 9636669; Product type pt : putative transporter; putative outer membrane porin 678889 ybfM 7151533 ybfM Escherichia coli IAI39 putative outer membrane porin YP_002406664.1 677483 D 585057 CDS YP_002406665.1 218699036 7153327 678939..679265 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein 679265 ybfN 7153327 ybfN Escherichia coli IAI39 putative lipoprotein YP_002406665.1 678939 D 585057 CDS YP_002406666.1 218699037 7153328 complement(679349..679795) 1 NC_011750.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator 679795 fur 7153328 fur Escherichia coli IAI39 ferric uptake regulator YP_002406666.1 679349 R 585057 CDS YP_002406667.1 218699038 7151456 679840..680094 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 680094 7151456 ECIAI39_0641 Escherichia coli IAI39 hypothetical protein YP_002406667.1 679840 D 585057 CDS YP_002406668.1 218699039 7149604 complement(680084..680614) 1 NC_011750.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA 680614 fldA 7149604 fldA Escherichia coli IAI39 flavodoxin FldA YP_002406668.1 680084 R 585057 CDS YP_002406669.1 218699040 7151347 complement(680754..681047) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20223640, 12427949; Product type cp : cell process; LexA regulated protein 681047 ybfE 7151347 ybfE Escherichia coli IAI39 LexA regulated protein YP_002406669.1 680754 R 585057 CDS YP_002406670.1 218699041 7153325 complement(681187..681951) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme; hypothetical protein 681951 ybfF 7153325 ybfF Escherichia coli IAI39 hypothetical protein YP_002406670.1 681187 R 585057 CDS YP_002406671.1 218699042 7153326 682136..682681 1 NC_011750.1 negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 682681 seqA 7153326 seqA Escherichia coli IAI39 replication initiation regulator SeqA YP_002406671.1 682136 D 585057 CDS YP_002406672.1 218699043 7152829 682707..684347 1 NC_011750.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 684347 pgm 7152829 pgm Escherichia coli IAI39 phosphoglucomutase YP_002406672.1 682707 D 585057 CDS YP_002406673.1 218699044 7152384 684552..685046 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 685046 ybfP 7152384 ybfP Escherichia coli IAI39 hypothetical protein YP_002406673.1 684552 D 585057 CDS YP_002406674.1 218699045 7153329 complement(685087..685845) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 685845 7153329 ECIAI39_0648 Escherichia coli IAI39 hypothetical protein YP_002406674.1 685087 R 585057 CDS YP_002406675.1 218699046 7149605 complement(685815..685964) 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 685964 7149605 ECIAI39_0649 Escherichia coli IAI39 hypothetical protein YP_002406675.1 685815 R 585057 CDS YP_002406676.1 218699047 7149606 complement(686086..687405) 1 NC_011750.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter 687405 potE 7149606 potE Escherichia coli IAI39 putrescine transporter YP_002406676.1 686086 R 585057 CDS YP_002406677.1 218699048 7152445 complement(687402..689600) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92041955; Product type e : enzyme; ornithine decarboxylase 689600 speF 7152445 speF Escherichia coli IAI39 ornithine decarboxylase YP_002406677.1 687402 R 585057 CDS YP_002406678.1 218699049 7152884 689723..689980 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 689980 7152884 ECIAI39_0652 Escherichia coli IAI39 hypothetical protein YP_002406678.1 689723 D 585057 CDS YP_002406679.1 218699050 7149607 complement(690196..690873) 1 NC_011750.1 response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; DNA-binding transcriptional activator KdpE 690873 kdpE 7149607 kdpE Escherichia coli IAI39 DNA-binding transcriptional activator KdpE YP_002406679.1 690196 R 585057 CDS YP_002406680.1 218699051 7151884 complement(690870..693554) 1 NC_011750.1 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; sensor protein KdpD 693554 kdpD 7151884 kdpD Escherichia coli IAI39 sensor protein KdpD YP_002406680.1 690870 R 585057 CDS YP_002406681.1 218699052 7151883 complement(693547..694119) 1 NC_011750.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 694119 kdpC 7151883 kdpC Escherichia coli IAI39 potassium-transporting ATPase subunit C YP_002406681.1 693547 R 585057 CDS YP_002406682.1 218699053 7151882 complement(694128..696176) 1 NC_011750.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 696176 kdpB 7151882 kdpB Escherichia coli IAI39 potassium-transporting ATPase subunit B YP_002406682.1 694128 R 585057 CDS YP_002406683.1 218699054 7151881 complement(696199..697872) 1 NC_011750.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 697872 kdpA 7151881 kdpA Escherichia coli IAI39 potassium-transporting ATPase subunit A YP_002406683.1 696199 R 585057 CDS YP_002406684.1 218699055 7151880 698274..698480 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 698480 ybfA 7151880 ybfA Escherichia coli IAI39 hypothetical protein YP_002406684.1 698274 D 585057 CDS YP_002406685.1 218699056 7153324 698581..699090 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6325460, 8387990; hypothetical protein 699090 ybgA 7153324 ybgA Escherichia coli IAI39 hypothetical protein YP_002406685.1 698581 D 585057 CDS YP_002406686.1 218699057 7153330 699087..700505 1 NC_011750.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 700505 phr 7153330 phr Escherichia coli IAI39 deoxyribodipyrimidine photolyase YP_002406686.1 699087 D 585057 CDS YP_002406687.1 218699058 7152419 complement(700548..702029) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15175316; Product type pt : putative transporter; putative transporter 702029 ybgH 7152419 ybgH Escherichia coli IAI39 putative transporter YP_002406687.1 700548 R 585057 CDS YP_002406688.1 218699059 7153334 702300..703043 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14519207; putative hydrolase-oxidase 703043 ybgI 7153334 ybgI Escherichia coli IAI39 putative hydrolase-oxidase YP_002406688.1 702300 D 585057 CDS YP_002406689.1 218699060 7153335 703066..703722 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase subunit 703722 ybgJ 7153335 ybgJ Escherichia coli IAI39 putative hydrolase subunit YP_002406689.1 703066 D 585057 CDS YP_002406690.1 218699061 7153336 703716..704648 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase subunit 704648 ybgK 7153336 ybgK Escherichia coli IAI39 putative hydrolase subunit YP_002406690.1 703716 D 585057 CDS YP_002406691.1 218699062 7153337 704638..705372 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1729609; Product type pe : putative enzyme; LamB/YcsF family protein 705372 ybgL 7153337 ybgL Escherichia coli IAI39 LamB/YcsF family protein YP_002406691.1 704638 D 585057 CDS YP_002406692.1 218699063 7153338 705408..706199 1 NC_011750.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 706199 nei 7153338 nei Escherichia coli IAI39 endonuclease VIII YP_002406692.1 705408 D 585057 CDS YP_002406693.1 218699064 7152204 complement(706196..707242) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8002588; Product type ph : phenotype; hypothetical protein 707242 abrB 7152204 abrB Escherichia coli IAI39 hypothetical protein YP_002406693.1 706196 R 585057 CDS YP_002406694.1 218699065 7150655 complement(707422..708135) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative GntR family regulator 708135 7150655 ECIAI39_0668 Escherichia coli IAI39 putative GntR family regulator YP_002406694.1 707422 R 585057 CDS YP_002406695.1 218699066 7149608 708342..709085 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Demethylmenaquinone methyltransferase 709085 7149608 ECIAI39_0669 Escherichia coli IAI39 putative Demethylmenaquinone methyltransferase YP_002406695.1 708342 D 585057 CDS YP_002406696.1 218699067 7149609 709098..710111 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative zinc-type alcohol dehydrogenase 710111 7149609 ECIAI39_0670 Escherichia coli IAI39 putative zinc-type alcohol dehydrogenase YP_002406696.1 709098 D 585057 CDS YP_002406697.1 218699068 7149610 710123..710878 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Short-chain dehydrogenase/reductase SDR 710878 7149610 ECIAI39_0671 Escherichia coli IAI39 putative Short-chain dehydrogenase/reductase SDR YP_002406697.1 710123 D 585057 CDS YP_002406698.1 218699069 7149611 710893..711204 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 711204 7149611 ECIAI39_0672 Escherichia coli IAI39 putative hydrolase YP_002406698.1 710893 D 585057 CDS YP_002406699.1 218699070 7149612 711204..712400 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Altronate dehydratase 712400 7149612 ECIAI39_0673 Escherichia coli IAI39 putative Altronate dehydratase YP_002406699.1 711204 D 585057 CDS YP_002406700.1 218699071 7149613 712428..713396 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative C4-dicarboxylate-binding periplasmic protein 713396 7149613 ECIAI39_0674 Escherichia coli IAI39 putative C4-dicarboxylate-binding periplasmic protein YP_002406700.1 712428 D 585057 CDS YP_002406701.1 218699072 7149614 713420..713917 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative C4-dicarboxylate transporter small permease 713917 7149614 ECIAI39_0675 Escherichia coli IAI39 putative C4-dicarboxylate transporter small permease YP_002406701.1 713420 D 585057 CDS YP_002406702.1 218699073 7149615 713917..715227 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative C4-dicarboxylate transporter large permease 715227 7149615 ECIAI39_0676 Escherichia coli IAI39 putative C4-dicarboxylate transporter large permease YP_002406702.1 713917 D 585057 CDS YP_002406703.1 218699074 7149616 complement(715274..716557) 1 NC_011750.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 716557 gltA 7149616 gltA Escherichia coli IAI39 type II citrate synthase YP_002406703.1 715274 R 585057 CDS YP_002406704.1 218699075 7151548 complement(716763..716921) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 716921 7151548 ECIAI39_0678 Escherichia coli IAI39 hypothetical protein YP_002406704.1 716763 R 585057 CDS YP_002406705.1 218699076 7149617 717266..717655 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6237244, 89076355, 89123360, 9521736, 99414342, 11259408, 3309132, 6383359, 9822661; Product type m : membrane component; succinate dehydrogenase cytochrome b556 large membrane subunit 717655 sdhC 7149617 sdhC Escherichia coli IAI39 succinate dehydrogenase cytochrome b556 large membrane subunit YP_002406705.1 717266 D 585057 CDS YP_002406706.1 218699077 7152815 717649..717996 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82124790, 89076355, 9521736, 99414342, 6383359; Product type m : membrane component; succinate dehydrogenase cytochrome b556 small membrane subunit 717996 sdhD 7152815 sdhD Escherichia coli IAI39 succinate dehydrogenase cytochrome b556 small membrane subunit YP_002406706.1 717649 D 585057 CDS YP_002406707.1 218699078 7152816 717996..719762 1 NC_011750.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 719762 sdhA 7152816 sdhA Escherichia coli IAI39 succinate dehydrogenase flavoprotein subunit YP_002406707.1 717996 D 585057 CDS YP_002406708.1 218699079 7152813 719778..720494 1 NC_011750.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 720494 sdhB 7152813 sdhB Escherichia coli IAI39 succinate dehydrogenase iron-sulfur subunit YP_002406708.1 719778 D 585057 CDS YP_002406709.1 218699080 7152814 720695..723496 1 NC_011750.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 723496 sucA 7152814 sucA Escherichia coli IAI39 2-oxoglutarate dehydrogenase E1 component YP_002406709.1 720695 D 585057 CDS YP_002406710.1 218699081 7152918 723511..724728 1 NC_011750.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 724728 sucB 7152918 sucB Escherichia coli IAI39 dihydrolipoamide succinyltransferase YP_002406710.1 723511 D 585057 CDS YP_002406711.1 218699082 7152919 724822..725988 1 NC_011750.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 725988 sucC 7152919 sucC Escherichia coli IAI39 succinyl-CoA synthetase subunit beta YP_002406711.1 724822 D 585057 CDS YP_002406712.1 218699083 7152920 725988..726857 1 NC_011750.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 726857 sucD 7152920 sucD Escherichia coli IAI39 succinyl-CoA synthetase subunit alpha YP_002406712.1 725988 D 585057 CDS YP_002406713.1 218699084 7152778 complement(726956..728353) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 728353 7152778 ECIAI39_0687 Escherichia coli IAI39 hypothetical protein YP_002406713.1 726956 R 585057 CDS YP_002406714.1 218699085 7149618 729012..730808 1 NC_011750.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism; urocanate hydratase 730808 hutU 7149618 hutU Escherichia coli IAI39 urocanate hydratase YP_002406714.1 729012 D 585057 CDS YP_002406715.1 218699086 7151696 730927..732381 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative heterocycle metabolite transporter 732381 7151696 ECIAI39_0689 Escherichia coli IAI39 putative heterocycle metabolite transporter YP_002406715.1 730927 D 585057 CDS YP_002406716.1 218699087 7149619 732383..732973 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2203753; hypothetical protein 732973 7149619 ECIAI39_0690 Escherichia coli IAI39 hypothetical protein YP_002406716.1 732383 D 585057 CDS YP_002406717.1 218699088 7149620 732937..734181 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 16198643, 16475788, 10931887; Product type e : enzyme; imidazolonepropionase 734181 hutI 7149620 hutI Escherichia coli IAI39 imidazolonepropionase YP_002406717.1 732937 D 585057 CDS YP_002406718.1 218699089 7151695 734142..735131 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10931887, 2170334, 238937; Product type e : enzyme; formimidoylglutamase 735131 hutG 7151695 hutG Escherichia coli IAI39 formimidoylglutamase YP_002406718.1 734142 D 585057 CDS YP_002406719.1 218699090 7151693 complement(735094..735330) 1 NC_011750.1 hypothetical protein 735330 7151693 ECIAI39_0693 Escherichia coli IAI39 hypothetical protein YP_002406719.1 735094 R 585057 CDS YP_002406720.1 218699091 7149621 735182..736852 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8239649, 8204579; Product type e : enzyme; histidine ammonia-lyase (histidase) pre-protein 736852 hutH 7149621 hutH Escherichia coli IAI39 histidine ammonia-lyase (histidase) pre-protein YP_002406720.1 735182 D 585057 CDS YP_002406721.1 218699092 7151694 737123..738028 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative LysR-like transcriptional regulator 738028 7151694 ECIAI39_0695 Escherichia coli IAI39 putative LysR-like transcriptional regulator YP_002406721.1 737123 D 585057 CDS YP_002406722.1 218699093 7149622 complement(738062..738664) 1 NC_011750.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 738664 7149622 ECIAI39_0696 Escherichia coli IAI39 cob(I)yrinic acid a,c-diamide adenosyltransferase YP_002406722.1 738062 R 585057 CDS YP_002406723.1 218699094 7149623 complement(738674..740326) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; fumarase 740326 7149623 ECIAI39_0697 Escherichia coli IAI39 fumarase YP_002406723.1 738674 R 585057 CDS YP_002406724.1 218699095 7149624 complement(740434..741735) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative symport protein 741735 7149624 ECIAI39_0698 Escherichia coli IAI39 putative symport protein YP_002406724.1 740434 R 585057 CDS YP_002406725.1 218699096 7149625 complement(741875..742192) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 742192 7149625 ECIAI39_0699 Escherichia coli IAI39 hypothetical protein YP_002406725.1 741875 R 585057 CDS YP_002406726.1 218699097 7149626 complement(742189..743559) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11748244; Product type pe : putative enzyme; putative 3-methylaspartate ammonia-lyase, glutamate mutase 743559 7149626 ECIAI39_0700 Escherichia coli IAI39 putative 3-methylaspartate ammonia-lyase, glutamate mutase YP_002406726.1 742189 R 585057 CDS YP_002406727.1 218699098 7149627 complement(743563..744804) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; methylaspartate ammonia-lyase 744804 7149627 ECIAI39_0701 Escherichia coli IAI39 methylaspartate ammonia-lyase YP_002406727.1 743563 R 585057 CDS YP_002406728.1 218699099 7149628 complement(744804..746249) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; glutamate mutase subunit epsilon 746249 7149628 ECIAI39_0702 Escherichia coli IAI39 glutamate mutase subunit epsilon YP_002406728.1 744804 R 585057 CDS YP_002406729.1 218699100 7149629 complement(746268..747656) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7880251; Product type e : enzyme; glutamate mutase, large subunit, B12-dependent 747656 glmL 7149629 glmL Escherichia coli IAI39 glutamate mutase, large subunit, B12-dependent YP_002406729.1 746268 R 585057 CDS YP_002406730.1 218699101 7151519 complement(747656..748168) 1 NC_011750.1 converts methylaspartate to L-glutamate; methylaspartate mutase subunit S 748168 7151519 ECIAI39_0704 Escherichia coli IAI39 methylaspartate mutase subunit S YP_002406730.1 747656 R 585057 CDS YP_002406731.1 218699102 7149630 complement(748292..748459) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 748459 7149630 ECIAI39_0705 Escherichia coli IAI39 hypothetical protein YP_002406731.1 748292 R 585057 CDS YP_002406732.1 218699103 7149631 complement(748652..749074) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 749074 7149631 ECIAI39_0706 Escherichia coli IAI39 hypothetical protein YP_002406732.1 748652 R 585057 CDS YP_002406733.1 218699104 7149632 complement(749155..750099) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 750099 7149632 ECIAI39_0707 Escherichia coli IAI39 hypothetical protein YP_002406733.1 749155 R 585057 CDS YP_002406734.1 218699105 7149633 750905..752473 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87299685, 89255232, 91035243, 1689724, 1724280, 2843510, 3138232; Product type c : carrier; cytochrome d terminal oxidase subunit I 752473 cydA 7149633 cydA Escherichia coli IAI39 cytochrome d terminal oxidase subunit I YP_002406734.1 750905 D 585057 CDS YP_002406735.1 218699106 7151042 752489..753628 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87299685, 89255232, 91035243, 2843510, 3138232; Product type c : carrier; cytochrome d terminal oxidase subunit II 753628 cydB 7151042 cydB Escherichia coli IAI39 cytochrome d terminal oxidase subunit II YP_002406735.1 752489 D 585057 CDS YP_002406736.1 218699107 7151043 753756..754049 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 754049 ybgE 7151043 ybgE Escherichia coli IAI39 hypothetical protein YP_002406736.1 753756 D 585057 CDS YP_002406737.1 218699108 7153332 754199..754603 1 NC_011750.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase YbgC 754603 ybgC 7153332 ybgC Escherichia coli IAI39 acyl-CoA thioester hydrolase YbgC YP_002406737.1 754199 D 585057 CDS YP_002406738.1 218699109 7153331 754600..755292 1 NC_011750.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 755292 tolQ 7153331 tolQ Escherichia coli IAI39 colicin uptake protein TolQ YP_002406738.1 754600 D 585057 CDS YP_002406739.1 218699110 7152999 755296..755724 1 NC_011750.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 755724 tolR 7152999 tolR Escherichia coli IAI39 colicin uptake protein TolR YP_002406739.1 755296 D 585057 CDS YP_002406740.1 218699111 7153000 755789..757024 1 NC_011750.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 757024 tolA 7153000 tolA Escherichia coli IAI39 cell envelope integrity inner membrane protein TolA YP_002406740.1 755789 D 585057 CDS YP_002406741.1 218699112 7152996 757157..758449 1 NC_011750.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 758449 tolB 7152996 tolB Escherichia coli IAI39 translocation protein TolB YP_002406741.1 757157 D 585057 CDS YP_002406742.1 218699113 7152997 758484..759005 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11790745, 87133578, 92244043, 99403391, 11173492, 2687247; Product type lp : lipoprotein; peptidoglycan-associated outer membrane lipoprotein 759005 pal 7152997 pal Escherichia coli IAI39 peptidoglycan-associated outer membrane lipoprotein YP_002406742.1 758484 D 585057 CDS YP_002406743.1 218699114 7152322 759015..759806 1 NC_011750.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 759806 ybgF 7152322 ybgF Escherichia coli IAI39 tol-pal system protein YbgF YP_002406743.1 759015 D 585057 CDS YP_002406744.1 218699115 7150628 760922..761965 1 NC_011750.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 761965 nadA 7150628 nadA Escherichia coli IAI39 quinolinate synthetase YP_002406744.1 760922 D 585057 CDS YP_002406745.1 218699116 7152165 762003..762722 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 219824, 90330519; Product type t : transporter; nicotinamide mononucleotide transporter 762722 pnuC 7152165 pnuC Escherichia coli IAI39 nicotinamide mononucleotide transporter YP_002406745.1 762003 D 585057 CDS YP_002406746.1 218699117 7152438 complement(762719..763660) 1 NC_011750.1 involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB 763660 zitB 7152438 zitB Escherichia coli IAI39 zinc transporter ZitB YP_002406746.1 762719 R 585057 CDS YP_002406747.1 218699118 7154589 complement(763774..764154) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 764154 ybgS 7154589 ybgS Escherichia coli IAI39 hypothetical protein YP_002406747.1 763774 R 585057 CDS YP_002406748.1 218699119 7153339 764470..765522 1 NC_011750.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 765522 aroG 7153339 aroG Escherichia coli IAI39 phospho-2-dehydro-3-deoxyheptonate aldolase YP_002406748.1 764470 D 585057 CDS YP_002406749.1 218699120 7150781 complement(765689..766441) 1 NC_011750.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 766441 gpmA 7150781 gpmA Escherichia coli IAI39 phosphoglyceromutase YP_002406749.1 765689 R 585057 CDS YP_002406750.1 218699121 7151578 complement(766644..767684) 1 NC_011750.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase 767684 galM 7151578 galM Escherichia coli IAI39 aldose 1-epimerase YP_002406750.1 766644 R 585057 CDS YP_002406751.1 218699122 7151473 complement(767678..768826) 1 NC_011750.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 768826 galK 7151473 galK Escherichia coli IAI39 galactokinase YP_002406751.1 767678 R 585057 CDS YP_002406752.1 218699123 7151472 complement(768830..769876) 1 NC_011750.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 769876 galT 7151472 galT Escherichia coli IAI39 galactose-1-phosphate uridylyltransferase YP_002406752.1 768830 R 585057 CDS YP_002406753.1 218699124 7151477 complement(769886..770902) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89274199, 92253563, 92338916, 3022232, 6301942, 8564363, 8611559, 8931134, 9174344, 9271499, 9708982; Product type e : enzyme; UDP-galactose-4-epimerase 770902 galE 7151477 galE Escherichia coli IAI39 UDP-galactose-4-epimerase YP_002406753.1 769886 R 585057 CDS YP_002406754.1 218699125 7151470 complement(771164..772636) 1 NC_011750.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum; putative molybdenum transport ATP-binding protein ModF 772636 modF 7151470 modF Escherichia coli IAI39 putative molybdenum transport ATP-binding protein ModF YP_002406754.1 771164 R 585057 CDS YP_002406755.1 218699126 7152107 complement(772704..773492) 1 NC_011750.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE 773492 modE 7152107 modE Escherichia coli IAI39 DNA-binding transcriptional regulator ModE YP_002406755.1 772704 R 585057 CDS YP_002406756.1 218699127 7152106 773621..773770 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 773770 ybhT 7152106 ybhT Escherichia coli IAI39 hypothetical protein YP_002406756.1 773621 D 585057 CDS YP_002406757.1 218699128 7153356 773937..774710 1 NC_011750.1 with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein 774710 modA 7153356 modA Escherichia coli IAI39 molybdate transporter periplasmic protein YP_002406757.1 773937 D 585057 CDS YP_002406758.1 218699129 7152102 774710..775399 1 NC_011750.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 775399 modB 7152102 modB Escherichia coli IAI39 molybdate ABC transporter permease YP_002406758.1 774710 D 585057 CDS YP_002406759.1 218699130 7152103 775402..776460 1 NC_011750.1 Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 776460 modC 7152103 modC Escherichia coli IAI39 molybdate transporter ATP-binding protein YP_002406759.1 775402 D 585057 CDS YP_002406760.1 218699131 7152104 complement(776461..777279) 1 NC_011750.1 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase 777279 ybhA 7152104 ybhA Escherichia coli IAI39 phosphotransferase YP_002406760.1 776461 R 585057 CDS YP_002406761.1 218699132 7153340 777434..778429 1 NC_011750.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 778429 pgl 7153340 pgl Escherichia coli IAI39 6-phosphogluconolactonase YP_002406761.1 777434 D 585057 CDS YP_002406762.1 218699133 7152383 complement(778470..779486) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 779486 ybhD 7152383 ybhD Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002406762.1 778470 R 585057 CDS YP_002406763.1 218699134 7153343 779605..779880 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 779880 insA 7153343 insA Escherichia coli IAI39 IS1 repressor protein InsA YP_002406763.1 779605 D 585057 CDS YP_002406764.1 218699135 7151782 779799..780302 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 780302 insB 7151782 insB Escherichia coli IAI39 IS1 transposase InsAB' YP_002406764.1 779799 D 585057 CDS YP_002406765.1 218699136 7151793 780371..782395 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11782506; Product type pe : putative enzyme; hypothetical protein 782395 ybhJ 7151793 ybhJ Escherichia coli IAI39 hypothetical protein YP_002406765.1 780371 D 585057 CDS YP_002406766.1 218699137 7153346 complement(782466..783749) 1 NC_011750.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family; putative pectinesterase 783749 ybhC 7153346 ybhC Escherichia coli IAI39 putative pectinesterase YP_002406766.1 782466 R 585057 CDS YP_002406767.1 218699138 7153342 complement(783884..784654) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12754248, 12468081, 1715186, 6271639; Product type e : enzyme; phage integrase 784654 7153342 ECIAI39_0741 Escherichia coli IAI39 phage integrase YP_002406767.1 783884 R 585057 CDS YP_002406768.1 218699139 7149634 complement(784853..785299) 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 785299 7149634 ECIAI39_0742 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002406768.1 784853 R 585057 CDS YP_002406769.1 218699140 7150521 complement(785416..786939) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9353259, 10413481; Product type e : enzyme; Group II intron-encoded reverse transcriptase/maturase 786939 7150521 ECIAI39_0743 Escherichia coli IAI39 Group II intron-encoded reverse transcriptase/maturase YP_002406769.1 785416 R 585057 CDS YP_002406770.1 218699141 7149636 complement(787531..788013) 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 788013 7149636 ECIAI39_0744 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002406770.1 787531 R 585057 CDS YP_002406771.1 218699142 7149637 complement(788010..788336) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 788336 7149637 ECIAI39_0745 Escherichia coli IAI39 transposase ORF A, IS629 YP_002406771.1 788010 R 585057 CDS YP_002406772.1 218699143 7149638 788298..788900 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7626018; Product type e : enzyme; Endo-alpha-sialidase, phage head protein 788900 7149638 ECIAI39_0746 Escherichia coli IAI39 Endo-alpha-sialidase, phage head protein YP_002406772.1 788298 D 585057 CDS YP_002406773.1 218699144 7149639 complement(789137..789292) 1 NC_011750.1 hypothetical protein 789292 7149639 ECIAI39_0747 Escherichia coli IAI39 hypothetical protein YP_002406773.1 789137 R 585057 CDS YP_002406774.1 218699145 7152211 complement(790398..790874) 1 NC_011750.1 YbhB; similar to rat and human kinase inhibitory proteins; putative kinase inhibitor protein 790874 ybhB 7152211 ybhB Escherichia coli IAI39 putative kinase inhibitor protein YP_002406774.1 790398 R 585057 CDS YP_002406775.1 218699146 7153341 complement(790933..792222) 1 NC_011750.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine--8-amino-7-oxononanoate transaminase 792222 bioA 7153341 bioA Escherichia coli IAI39 adenosylmethionine--8-amino-7-oxononanoate transaminase YP_002406775.1 790933 R 585057 CDS YP_002406776.1 218699147 7150862 792309..793349 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11834738, 12475249, 14704425, 14967041, 20250955, 89066784, 94170810, 94190882, 97382445, 11686925; Product type e : enzyme; biotin synthase 793349 bioB 7150862 bioB Escherichia coli IAI39 biotin synthase YP_002406776.1 792309 D 585057 CDS YP_002406777.1 218699148 7150863 793346..794500 1 NC_011750.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 794500 bioF 7150863 bioF Escherichia coli IAI39 8-amino-7-oxononanoate synthase YP_002406777.1 793346 D 585057 CDS YP_002406778.1 218699149 7150866 794487..795242 1 NC_011750.1 putative methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 795242 bioC 7150866 bioC Escherichia coli IAI39 biotin biosynthesis protein BioC YP_002406778.1 794487 D 585057 CDS YP_002406779.1 218699150 7150864 795235..795912 1 NC_011750.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 795912 bioD 7150864 bioD Escherichia coli IAI39 dithiobiotin synthetase YP_002406779.1 795235 D 585057 CDS YP_002406780.1 218699151 7150865 796491..798512 1 NC_011750.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 798512 uvrB 7150865 uvrB Escherichia coli IAI39 excinuclease ABC subunit B YP_002406780.1 796491 D 585057 CDS YP_002406781.1 218699152 7153114 complement(798550..799458) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16272399; Product type pe : putative enzyme; putative transferase 799458 ybhK 7153114 ybhK Escherichia coli IAI39 putative transferase YP_002406781.1 798550 R 585057 CDS YP_002406782.1 218699153 7153347 799855..800844 1 NC_011750.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 800844 moaA 7153347 moaA Escherichia coli IAI39 molybdenum cofactor biosynthesis protein A YP_002406782.1 799855 D 585057 CDS YP_002406783.1 218699154 7152095 800866..801378 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93368423; Product type pf : putative factor; molybdopterin biosynthesis protein B 801378 moaB 7152095 moaB Escherichia coli IAI39 molybdopterin biosynthesis protein B YP_002406783.1 800866 D 585057 CDS YP_002406784.1 218699155 7152096 801381..801866 1 NC_011750.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 801866 moaC 7152096 moaC Escherichia coli IAI39 molybdenum cofactor biosynthesis protein MoaC YP_002406784.1 801381 D 585057 CDS YP_002406785.1 218699156 7152097 801859..802104 1 NC_011750.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 802104 moaD 7152097 moaD Escherichia coli IAI39 molybdopterin synthase small subunit YP_002406785.1 801859 D 585057 CDS YP_002406786.1 218699157 7152098 802106..802558 1 NC_011750.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin guanine dinucleotide biosynthesis protein MoaE 802558 moaE 7152098 moaE Escherichia coli IAI39 molybdopterin guanine dinucleotide biosynthesis protein MoaE YP_002406786.1 802106 D 585057 CDS YP_002406787.1 218699158 7152099 802695..803399 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 803399 ybhL 7152099 ybhL Escherichia coli IAI39 hypothetical protein YP_002406787.1 802695 D 585057 CDS YP_002406788.1 218699159 7153348 803606..804319 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 804319 ybhM 7153348 ybhM Escherichia coli IAI39 hypothetical protein YP_002406788.1 803606 D 585057 CDS YP_002406789.1 218699160 7153349 complement(804355..805311) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 805311 ybhN 7153349 ybhN Escherichia coli IAI39 hypothetical protein YP_002406789.1 804355 R 585057 CDS YP_002406790.1 218699161 7153350 complement(805311..806552) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20102623, 10634942; Product type e : enzyme; cardiolipin synthase 2 806552 ybhO 7153350 ybhO Escherichia coli IAI39 cardiolipin synthase 2 YP_002406790.1 805311 R 585057 CDS YP_002406791.1 218699162 7153351 complement(806549..807310) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal-dependent hydrolase 807310 ybhP 7153351 ybhP Escherichia coli IAI39 putative metal-dependent hydrolase YP_002406791.1 806549 R 585057 CDS YP_002406792.1 218699163 7153352 807443..807853 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 807853 ybhQ 7153352 ybhQ Escherichia coli IAI39 hypothetical protein YP_002406792.1 807443 D 585057 CDS YP_002406793.1 218699164 7153353 complement(807815..808921) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease 808921 ybhR 7153353 ybhR Escherichia coli IAI39 putative ABC transporter permease YP_002406793.1 807815 R 585057 CDS YP_002406794.1 218699165 7153354 complement(808932..810065) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease 810065 ybhS 7153354 ybhS Escherichia coli IAI39 putative ABC transporter permease YP_002406794.1 808932 R 585057 CDS YP_002406795.1 218699166 7153355 complement(810058..811794) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 811794 ybhF 7153355 ybhF Escherichia coli IAI39 putative ABC transporter ATP-binding protein YP_002406795.1 810058 R 585057 CDS YP_002406796.1 218699167 7153344 complement(811787..812785) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16092522; Product type pt : putative transporter; hypothetical protein 812785 ybhG 7153344 ybhG Escherichia coli IAI39 hypothetical protein YP_002406796.1 811787 R 585057 CDS YP_002406797.1 218699168 7153345 complement(812785..813456) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 813456 ybiH 7153345 ybiH Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002406797.1 812785 R 585057 CDS YP_002406798.1 218699169 7153359 813685..815046 1 NC_011750.1 this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 815046 rhlE 7153359 rhlE Escherichia coli IAI39 ATP-dependent RNA helicase RhlE YP_002406798.1 813685 D 585057 CDS YP_002406799.1 218699170 7152619 815198..815341 1 NC_011750.1 hypothetical protein 815341 7152619 ECIAI39_0774 Escherichia coli IAI39 hypothetical protein YP_002406799.1 815198 D 585057 CDS YP_002406800.1 218699171 7149641 815653..817665 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative toxin 817665 7149641 ECIAI39_0775 Escherichia coli IAI39 putative toxin YP_002406800.1 815653 D 585057 CDS YP_002406801.1 218699172 7149642 817947..820097 1 NC_011750.1 helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 820097 dinG 7149642 dinG Escherichia coli IAI39 ATP-dependent DNA helicase DinG YP_002406801.1 817947 D 585057 CDS YP_002406802.1 218699173 7151140 820125..821087 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; glycosyl transferase family protein 821087 ybiB 7151140 ybiB Escherichia coli IAI39 glycosyl transferase family protein YP_002406802.1 820125 D 585057 CDS YP_002406803.1 218699174 7153357 821228..822313 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8405966; Product type pe : putative enzyme; hypothetical protein 822313 ybiC 7153357 ybiC Escherichia coli IAI39 hypothetical protein YP_002406803.1 821228 D 585057 CDS YP_002406804.1 218699175 7153358 complement(822453..822713) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 822713 ybiJ 7153358 ybiJ Escherichia coli IAI39 hypothetical protein YP_002406804.1 822453 R 585057 CDS YP_002406805.1 218699176 7153361 complement(822978..823244) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 823244 ybiI 7153361 ybiI Escherichia coli IAI39 hypothetical protein YP_002406805.1 822978 R 585057 CDS YP_002406806.1 218699177 7153360 complement(823318..823995) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative hydroxylase 823995 ybiX 7153360 ybiX Escherichia coli IAI39 putative hydroxylase YP_002406806.1 823318 R 585057 CDS YP_002406807.1 218699178 7153372 complement(824037..826319) 1 NC_011750.1 Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein; catecholate siderophore receptor Fiu 826319 fiu 7153372 fiu Escherichia coli IAI39 catecholate siderophore receptor Fiu YP_002406807.1 824037 R 585057 CDS YP_002406808.1 218699179 7151339 complement(826338..826421) 1 NC_011750.1 hypothetical protein 826421 7151339 ECIAI39_0783 Escherichia coli IAI39 hypothetical protein YP_002406808.1 826338 R 585057 CDS YP_002406809.1 218699180 7149643 complement(826584..826988) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 826988 ybiM 7149643 ybiM Escherichia coli IAI39 hypothetical protein YP_002406809.1 826584 R 585057 CDS YP_002406810.1 218699181 7153362 827120..828046 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative SAM-dependent methyltransferase 828046 ybiN 7153362 ybiN Escherichia coli IAI39 putative SAM-dependent methyltransferase YP_002406810.1 827120 D 585057 CDS YP_002406811.1 218699182 7153363 complement(828043..830268) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 830268 ybiO 7153363 ybiO Escherichia coli IAI39 hypothetical protein YP_002406811.1 828043 R 585057 CDS YP_002406812.1 218699183 7153364 complement(830385..831107) 1 NC_011750.1 similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein 831107 glnQ 7153364 glnQ Escherichia coli IAI39 glutamine ABC transporter ATP-binding protein YP_002406812.1 830385 R 585057 CDS YP_002406813.1 218699184 7151532 complement(831104..831763) 1 NC_011750.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease 831763 glnP 7151532 glnP Escherichia coli IAI39 glutamine ABC transporter permease YP_002406813.1 831104 R 585057 CDS YP_002406814.1 218699185 7151531 complement(831902..832648) 1 NC_011750.1 similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein 832648 glnH 7151531 glnH Escherichia coli IAI39 glutamine ABC transporter periplasmic protein YP_002406814.1 831902 R 585057 CDS YP_002406815.1 218699186 7151528 complement(833052..833555) 1 NC_011750.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps 833555 dps 7151528 dps Escherichia coli IAI39 DNA starvation/stationary phase protection protein Dps YP_002406815.1 833052 R 585057 CDS YP_002406816.1 218699187 7151171 complement(833855..834742) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12648727, 8021175; Product type t : transporter; threonine and homoserine efflux system 834742 rhtA 7151171 rhtA Escherichia coli IAI39 threonine and homoserine efflux system YP_002406816.1 833855 R 585057 CDS YP_002406817.1 218699188 7152622 835095..835610 1 NC_011750.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 835610 ompX 7152622 ompX Escherichia coli IAI39 outer membrane protein X YP_002406817.1 835095 D 585057 CDS YP_002406818.1 218699189 7152299 complement(835659..837242) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16514146; Product type pe : putative enzyme; hypothetical protein 837242 ybiP 7152299 ybiP Escherichia coli IAI39 hypothetical protein YP_002406818.1 835659 R 585057 CDS YP_002406819.1 218699190 7152776 837828..838295 1 NC_011750.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 838295 mntR 7152776 mntR Escherichia coli IAI39 manganese transport regulator MntR YP_002406819.1 837828 D 585057 CDS YP_002406820.1 218699191 7152094 838292..839410 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 839410 ybiR 7152094 ybiR Escherichia coli IAI39 putative transporter YP_002406820.1 838292 D 585057 CDS YP_002406821.1 218699192 7153366 complement(839469..840389) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10493123, 9298646; hypothetical protein 840389 ybiS 7153366 ybiS Escherichia coli IAI39 hypothetical protein YP_002406821.1 839469 R 585057 CDS YP_002406822.1 218699193 7153367 840608..842200 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11916677; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 842200 ybiT 7153367 ybiT Escherichia coli IAI39 putative ABC transporter ATP-binding protein YP_002406822.1 840608 D 585057 CDS YP_002406823.1 218699194 7153368 complement(842450..843709) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 843709 ybiU 7153368 ybiU Escherichia coli IAI39 hypothetical protein YP_002406823.1 842450 R 585057 CDS YP_002406824.1 218699195 7153369 complement(843861..844676) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15657928; Product type e : enzyme; type II HAD phosphatase 844676 ybiV 7153369 ybiV Escherichia coli IAI39 type II HAD phosphatase YP_002406824.1 843861 R 585057 CDS YP_002406825.1 218699196 7153370 complement(844822..847254) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16218870; Product type pe : putative enzyme; putative glycyl radical cofactor protein 847254 ybiW 7153370 ybiW Escherichia coli IAI39 putative glycyl radical cofactor protein YP_002406825.1 844822 R 585057 CDS YP_002406826.1 218699197 7153371 complement(847260..848186) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15581584; Product type pe : putative enzyme; putative AdoMet-dependent glycyl radical activating enzyme 848186 ybiY 7153371 ybiY Escherichia coli IAI39 putative AdoMet-dependent glycyl radical activating enzyme YP_002406826.1 847260 R 585057 CDS YP_002406827.1 218699198 7153373 848290..848952 1 NC_011750.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 848952 fsaA 7153373 fsaA Escherichia coli IAI39 fructose-6-phosphate aldolase YP_002406827.1 848290 D 585057 CDS YP_002406828.1 218699199 7151430 complement(849130..849879) 1 NC_011750.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 849879 moeB 7151430 moeB Escherichia coli IAI39 molybdopterin biosynthesis protein MoeB YP_002406828.1 849130 R 585057 CDS YP_002406829.1 218699200 7152109 complement(849879..851114) 1 NC_011750.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA 851114 moeA 7152109 moeA Escherichia coli IAI39 molybdopterin biosynthesis protein MoeA YP_002406829.1 849879 R 585057 CDS YP_002406830.1 218699201 7152108 851318..852283 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15159592, 20508248, 3045084, 7984428; Product type e : enzyme; L-asparaginase 852283 iaaA 7152108 iaaA Escherichia coli IAI39 L-asparaginase YP_002406830.1 851318 D 585057 CDS YP_002406831.1 218699202 7151741 852303..854141 1 NC_011750.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 854141 yliA 7151741 yliA Escherichia coli IAI39 glutathione transporter ATP-binding protein YP_002406831.1 852303 D 585057 CDS YP_002406832.1 218699203 7154370 854161..855699 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17366475; Product type pt : putative transporter; putative peptide ABC transporter periplasmic-binding protein 855699 yliB 7154370 yliB Escherichia coli IAI39 putative peptide ABC transporter periplasmic-binding protein YP_002406832.1 854161 D 585057 CDS YP_002406833.1 218699204 7154371 855717..856637 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative peptide ABC transporter permease 856637 yliC 7154371 yliC Escherichia coli IAI39 putative peptide ABC transporter permease YP_002406833.1 855717 D 585057 CDS YP_002406834.1 218699205 7154372 856640..857551 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative peptide ABC transporter permease 857551 yliD 7154372 yliD Escherichia coli IAI39 putative peptide ABC transporter permease YP_002406834.1 856640 D 585057 CDS YP_002406835.1 218699206 7154373 857729..860077 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 860077 yliE 7154373 yliE Escherichia coli IAI39 hypothetical protein YP_002406835.1 857729 D 585057 CDS YP_002406836.1 218699207 7154374 860085..861413 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type pe : putative enzyme; putative diguanylate cyclase 861413 yliF 7154374 yliF Escherichia coli IAI39 putative diguanylate cyclase YP_002406836.1 860085 D 585057 CDS YP_002406837.1 218699208 7154375 complement(861483..861812) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 861812 7154375 ECIAI39_0812 Escherichia coli IAI39 hypothetical protein YP_002406837.1 861483 R 585057 CDS YP_002406838.1 218699209 7149644 complement(861802..862188) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 862188 7149644 ECIAI39_0813 Escherichia coli IAI39 hypothetical protein YP_002406838.1 861802 R 585057 CDS YP_002406839.1 218699210 7149645 complement(862414..863739) 1 NC_011750.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase 863739 rimO 7149645 rimO Escherichia coli IAI39 ribosomal protein S12 methylthiotransferase YP_002406839.1 862414 R 585057 CDS YP_002406840.1 218699211 7154376 863952..864335 1 NC_011750.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 864335 bssR 7154376 bssR Escherichia coli IAI39 biofilm formation regulatory protein BssR YP_002406840.1 863952 D 585057 CDS YP_002406841.1 218699212 7150876 864446..865561 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16522795, 16864586; Product type e : enzyme; PQQ-dependent aldose sugar dehydrogenase (asd) 865561 yliI 7150876 yliI Escherichia coli IAI39 PQQ-dependent aldose sugar dehydrogenase (asd) YP_002406841.1 864446 D 585057 CDS YP_002406842.1 218699213 7154377 complement(865558..866184) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase 866184 yliJ 7154377 yliJ Escherichia coli IAI39 putative glutathione S-transferase YP_002406842.1 865558 R 585057 CDS YP_002406843.1 218699214 7154378 866431..867633 1 NC_011750.1 penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase fraction C 867633 dacC 7154378 dacC Escherichia coli IAI39 D-alanyl-D-alanine carboxypeptidase fraction C YP_002406843.1 866431 D 585057 CDS YP_002406844.1 218699215 7151078 complement(867680..868438) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89231635, 89336786, 92231401, 2994018; Product type r : regulator; DNA-binding transcriptional repressor DeoR 868438 deoR 7151078 deoR Escherichia coli IAI39 DNA-binding transcriptional repressor DeoR YP_002406844.1 867680 R 585057 CDS YP_002406845.1 218699216 7151121 complement(868496..869092) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15778224; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase 869092 ybjG 7151121 ybjG Escherichia coli IAI39 undecaprenyl pyrophosphate phosphatase YP_002406845.1 868496 R 585057 CDS YP_002406846.1 218699217 7153377 869377..870609 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10022825, 12578981, 14688269, 21217867, 21450803, 9079913, 9644262, 99030337, 8655497; Product type t : transporter; multidrug efflux system protein 870609 cmr 7153377 cmr Escherichia coli IAI39 multidrug efflux system protein YP_002406846.1 869377 D 585057 CDS YP_002406847.1 218699218 7150970 complement(870650..870934) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 870934 ybjH 7150970 ybjH Escherichia coli IAI39 hypothetical protein YP_002406847.1 870650 R 585057 CDS YP_002406848.1 218699219 7153378 complement(871019..871834) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme; putative phosphatase 871834 ybjI 7153378 ybjI Escherichia coli IAI39 putative phosphatase YP_002406848.1 871019 R 585057 CDS YP_002406849.1 218699220 7153379 complement(871834..873042) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 873042 ybjJ 7153379 ybjJ Escherichia coli IAI39 putative transporter YP_002406849.1 871834 R 585057 CDS YP_002406850.1 218699221 7153380 873126..873662 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 873662 ybjK 7153380 ybjK Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002406850.1 873126 D 585057 CDS YP_002406851.1 218699222 7152777 complement(873837..875522) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 875522 ybjL 7152777 ybjL Escherichia coli IAI39 hypothetical protein YP_002406851.1 873837 R 585057 CDS YP_002406852.1 218699223 7153382 875792..876169 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 876169 ybjM 7153382 ybjM Escherichia coli IAI39 hypothetical protein YP_002406852.1 875792 D 585057 CDS YP_002406853.1 218699224 7153383 complement(876199..876456) 1 NC_011750.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 1 876456 grxA 7153383 grxA Escherichia coli IAI39 glutaredoxin 1 YP_002406853.1 876199 R 585057 CDS YP_002406854.1 218699225 7151588 876616..876903 1 NC_011750.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 876903 ybjC 7151588 ybjC Escherichia coli IAI39 hypothetical protein YP_002406854.1 876616 D 585057 CDS YP_002406855.1 218699226 7153374 876887..877609 1 NC_011750.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 877609 nfsA 7153374 nfsA Escherichia coli IAI39 nitroreductase A YP_002406855.1 876887 D 585057 CDS YP_002406856.1 218699227 7152219 877670..878572 1 NC_011750.1 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 878572 rimK 7152219 rimK Escherichia coli IAI39 ribosomal protein S6 modification protein YP_002406856.1 877670 D 585057 CDS YP_002406857.1 218699228 7152636 878660..879136 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 879136 ybjN 7152636 ybjN Escherichia coli IAI39 hypothetical protein YP_002406857.1 878660 D 585057 CDS YP_002406858.1 218699229 7153384 879342..879503 1 NC_011750.1 hypothetical protein 879503 7153384 ECIAI39_0833 Escherichia coli IAI39 hypothetical protein YP_002406858.1 879342 D 585057 CDS YP_002406859.1 218699230 7149646 879487..880599 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992, 9651355, 9298646, 8416922; Product type t : transporter; putrescine ABC transporter periplasmic-binding protein 880599 potF 7149646 potF Escherichia coli IAI39 putrescine ABC transporter periplasmic-binding protein YP_002406859.1 879487 D 585057 CDS YP_002406860.1 218699231 7152446 880694..881827 1 NC_011750.1 part of the PotFGHI ATP-dependent putrescine transporter; putrescine transporter ATP-binding subunit 881827 potG 7152446 potG Escherichia coli IAI39 putrescine transporter ATP-binding subunit YP_002406860.1 880694 D 585057 CDS YP_002406861.1 218699232 7152447 881837..882790 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992; Product type t : transporter; putrescine ABC transporter membrane protein 882790 potH 7152447 potH Escherichia coli IAI39 putrescine ABC transporter membrane protein YP_002406861.1 881837 D 585057 CDS YP_002406862.1 218699233 7152448 882787..883632 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992; Product type t : transporter; putrescine ABC transporter membrane protein 883632 potI 7152448 potI Escherichia coli IAI39 putrescine ABC transporter membrane protein YP_002406862.1 882787 D 585057 CDS YP_002406863.1 218699234 7152449 883692..884180 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 884180 ybjO 7152449 ybjO Escherichia coli IAI39 hypothetical protein YP_002406863.1 883692 D 585057 CDS YP_002406864.1 218699235 7153385 884221..885348 1 NC_011750.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 885348 rumB 7153385 rumB Escherichia coli IAI39 23S rRNA methyluridine methyltransferase YP_002406864.1 884221 D 585057 CDS YP_002406865.1 218699236 7152763 complement(885377..886108) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93273744, 9298646, 9600841, 8801422; Product type t : transporter; arginine ABC transporter subunit periplasmic-binding protein 886108 artJ 7152763 artJ Escherichia coli IAI39 arginine ABC transporter subunit periplasmic-binding protein YP_002406865.1 885377 R 585057 CDS YP_002406866.1 218699237 7150791 complement(886400..887068) 1 NC_011750.1 with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM 887068 artM 7150791 artM Escherichia coli IAI39 arginine transporter permease subunit ArtM YP_002406866.1 886400 R 585057 CDS YP_002406867.1 218699238 7150792 complement(887068..887784) 1 NC_011750.1 with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ 887784 artQ 7150792 artQ Escherichia coli IAI39 arginine transporter permease subunit ArtQ YP_002406867.1 887068 R 585057 CDS YP_002406868.1 218699239 7150794 complement(887791..888522) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93273744, 9298646, 9600841, 8801422, 9740056; Product type t : transporter; arginine ABC transporter subunit periplasmic-binding protein 888522 artI 7150794 artI Escherichia coli IAI39 arginine ABC transporter subunit periplasmic-binding protein YP_002406868.1 887791 R 585057 CDS YP_002406869.1 218699240 7150790 complement(888540..889268) 1 NC_011750.1 With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit 889268 artP 7150790 artP Escherichia coli IAI39 arginine transporter ATP-binding subunit YP_002406869.1 888540 R 585057 CDS YP_002406870.1 218699241 7153386 890616..892418 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 892418 7153386 ECIAI39_0846 Escherichia coli IAI39 hypothetical protein YP_002406870.1 890616 D 585057 CDS YP_002406871.1 218699242 7149647 892629..892952 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 892952 ybjQ 7149647 ybjQ Escherichia coli IAI39 hypothetical protein YP_002406871.1 892629 D 585057 CDS YP_002406872.1 218699243 7153387 892949..893779 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cell wall amidase and lipoprotein 893779 ybjR 7153387 ybjR Escherichia coli IAI39 putative cell wall amidase and lipoprotein YP_002406872.1 892949 D 585057 CDS YP_002406873.1 218699244 7153388 complement(893776..894789) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P)H-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain 894789 ybjS 7153388 ybjS Escherichia coli IAI39 putative NAD(P)H-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain YP_002406873.1 893776 R 585057 CDS YP_002406874.1 218699245 7153389 complement(894888..896318) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 896318 ybjT 7153389 ybjT Escherichia coli IAI39 hypothetical protein YP_002406874.1 894888 R 585057 CDS YP_002406875.1 218699246 7153390 complement(896329..897330) 1 NC_011750.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase 897330 ltaE 7153390 ltaE Escherichia coli IAI39 L-threonine aldolase YP_002406875.1 896329 R 585057 CDS YP_002406876.1 218699247 7151980 complement(897367..899085) 1 NC_011750.1 catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase 899085 poxB 7151980 poxB Escherichia coli IAI39 pyruvate dehydrogenase YP_002406876.1 897367 R 585057 CDS YP_002406877.1 218699248 7152451 complement(899218..900186) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20117674; Product type e : enzyme; HCP oxidoreductase, NADH-dependent 900186 hcr 7152451 hcr Escherichia coli IAI39 HCP oxidoreductase, NADH-dependent YP_002406877.1 899218 R 585057 CDS YP_002406878.1 218699249 7151616 complement(900198..901850) 1 NC_011750.1 catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase 901850 hcp 7151616 hcp Escherichia coli IAI39 hydroxylamine reductase YP_002406878.1 900198 R 585057 CDS YP_002406879.1 218699250 7151615 complement(901994..902893) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 902893 ybjE 7151615 ybjE Escherichia coli IAI39 putative transporter YP_002406879.1 901994 R 585057 CDS YP_002406880.1 218699251 7149648 903233..904258 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase, IS110 family 904258 7149648 ECIAI39_0857 Escherichia coli IAI39 putative transposase, IS110 family YP_002406880.1 903233 D 585057 CDS YP_002406881.1 218699252 7149649 905415..906503 1 NC_011750.1 may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance outer membrane protein MdtQ 906503 yohG 7149649 yohG Escherichia coli IAI39 multidrug resistance outer membrane protein MdtQ YP_002406881.1 905415 D 585057 CDS YP_002406882.1 218699253 7154456 906556..907317 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; acetoin dehydrogenase 907317 yohF 7154456 yohF Escherichia coli IAI39 acetoin dehydrogenase YP_002406882.1 906556 D 585057 CDS YP_002406883.1 218699254 7154455 complement(907436..908014) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 908014 yohD 7154455 yohD Escherichia coli IAI39 hypothetical protein YP_002406883.1 907436 R 585057 CDS YP_002406884.1 218699255 7154454 908184..908771 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 908771 yohC 7154454 yohC Escherichia coli IAI39 hypothetical protein YP_002406884.1 908184 D 585057 CDS YP_002406885.1 218699256 7154453 908945..909877 1 NC_011750.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase 909877 pbpG 7154453 pbpG Escherichia coli IAI39 D-alanyl-D-alanine endopeptidase YP_002406885.1 908945 D 585057 CDS YP_002406886.1 218699257 7152350 complement(909916..911673) 1 NC_011750.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 911673 dld 7152350 dld Escherichia coli IAI39 D-lactate dehydrogenase YP_002406886.1 909916 R 585057 CDS YP_002406887.1 218699258 7151148 911828..914125 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96303506; Product type e : enzyme; beta-D-glucoside glucohydrolase 914125 bglX 7151148 bglX Escherichia coli IAI39 beta-D-glucoside glucohydrolase YP_002406887.1 911828 D 585057 CDS YP_002406888.1 218699259 7150861 914377..915294 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15251200; Product type pt : putative transporter; putative ABC transporter periplasmic-binding protein 915294 yehZ 7150861 yehZ Escherichia coli IAI39 putative ABC transporter periplasmic-binding protein YP_002406888.1 914377 D 585057 CDS YP_002406889.1 218699260 7153766 915301..916458 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease 916458 yehY 7153766 yehY Escherichia coli IAI39 putative ABC transporter permease YP_002406889.1 915301 D 585057 CDS YP_002406890.1 218699261 7153765 916451..917377 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein transporter 917377 yehX 7153765 yehX Escherichia coli IAI39 putative ABC transporter ATP-binding protein transporter YP_002406890.1 916451 D 585057 CDS YP_002406891.1 218699262 7153764 917382..918113 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease 918113 yehW 7153764 yehW Escherichia coli IAI39 putative ABC transporter permease YP_002406891.1 917382 D 585057 CDS YP_002406892.1 218699263 7153763 complement(918094..918201) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 918201 yohO 7153763 yohO Escherichia coli IAI39 hypothetical protein YP_002406892.1 918094 R 585057 CDS YP_002406893.1 218699264 7154461 complement(918261..918908) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11489123; Product type r : regulator; DNA-binding transcriptional regulator 918908 mlrA 7154461 mlrA Escherichia coli IAI39 DNA-binding transcriptional regulator YP_002406893.1 918261 R 585057 CDS YP_002406894.1 218699265 7152088 complement(918983..919393) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11686382, 11282477, 9562894, 8878031; Product type pe : putative enzyme; putative lambdoid prophage integrase 919393 7152088 ECIAI39_0871 Escherichia coli IAI39 putative lambdoid prophage integrase YP_002406894.1 918983 R 585057 CDS YP_002406895.1 218699266 7149650 complement(919480..919926) 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 919926 7149650 ECIAI39_0872 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002406895.1 919480 R 585057 CDS YP_002406896.1 218699267 7150522 complement(920043..921566) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9353259, 10413481; Product type e : enzyme; Group II intron-encoded reverse transcriptase/maturase 921566 7150522 ECIAI39_0873 Escherichia coli IAI39 Group II intron-encoded reverse transcriptase/maturase YP_002406896.1 920043 R 585057 CDS YP_002406897.1 218699268 7149652 complement(922158..922640) 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 922640 7149652 ECIAI39_0874 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002406897.1 922158 R 585057 CDS YP_002406898.1 218699269 7149653 complement(922637..922963) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 922963 7149653 ECIAI39_0875 Escherichia coli IAI39 transposase ORF A, IS629 YP_002406898.1 922637 R 585057 CDS YP_002406899.1 218699270 7149654 923080..925929 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11686382, 11282477, 9562894, 8878031; Product type f : factor; tail length tape measure protein 925929 7149654 ECIAI39_0876 Escherichia coli IAI39 tail length tape measure protein YP_002406899.1 923080 D 585057 CDS YP_002406900.1 218699271 7149655 925922..926263 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11686382, 11282477, 9562894, 8878031; Product type f : factor; minor tail protein M 926263 7149655 ECIAI39_0877 Escherichia coli IAI39 minor tail protein M YP_002406900.1 925922 D 585057 CDS YP_002406901.1 218699272 7149656 926263..926961 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein L 926961 7149656 ECIAI39_0878 Escherichia coli IAI39 minor tail protein L YP_002406901.1 926263 D 585057 CDS YP_002406902.1 218699273 7149657 926972..927715 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail fiber component K 927715 7149657 ECIAI39_0879 Escherichia coli IAI39 tail fiber component K YP_002406902.1 926972 D 585057 CDS YP_002406903.1 218699274 7149658 927613..928293 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein I 928293 7149658 ECIAI39_0880 Escherichia coli IAI39 tail assembly protein I YP_002406903.1 927613 D 585057 CDS YP_002406904.1 218699275 7149659 928637..932329 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J 932329 7149659 ECIAI39_0881 Escherichia coli IAI39 Host specificity protein J YP_002406904.1 928637 D 585057 CDS YP_002406905.1 218699276 7149660 932398..932997 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Lom-like outer membrane protein of prophage 932997 7149660 ECIAI39_0882 Escherichia coli IAI39 putative Lom-like outer membrane protein of prophage YP_002406905.1 932398 D 585057 CDS YP_002406906.1 218699277 7149661 933149..935209 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 935209 7149661 ECIAI39_0883 Escherichia coli IAI39 hypothetical protein YP_002406906.1 933149 D 585057 CDS YP_002406907.1 218699278 7149662 935206..935484 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 935484 7149662 ECIAI39_0884 Escherichia coli IAI39 hypothetical protein YP_002406907.1 935206 D 585057 CDS YP_002406908.1 218699279 7149663 935494..935790 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 935790 7149663 ECIAI39_0885 Escherichia coli IAI39 hypothetical protein YP_002406908.1 935494 D 585057 CDS YP_002406909.1 218699280 7149664 complement(935908..936156) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative damage-inducible protein dinI-like 936156 7149664 ECIAI39_0886 Escherichia coli IAI39 putative damage-inducible protein dinI-like YP_002406909.1 935908 R 585057 CDS YP_002406910.1 218699281 7149665 936671..938356 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15522865, 15322361; Product type rc : receptor; sensory kinase in two-component system with YehT 938356 yehU 7149665 yehU Escherichia coli IAI39 sensory kinase in two-component system with YehT YP_002406910.1 936671 D 585057 CDS YP_002406911.1 218699282 7153762 938353..939072 1 NC_011750.1 unknown function; when overproduced it confers drug-resistance; putative two-component response-regulatory protein YehT 939072 yehT 7153762 yehT Escherichia coli IAI39 putative two-component response-regulatory protein YehT YP_002406911.1 938353 D 585057 CDS YP_002406912.1 218699283 7153761 939119..939589 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 939589 yehS 7153761 yehS Escherichia coli IAI39 hypothetical protein YP_002406912.1 939119 D 585057 CDS YP_002406913.1 218699284 7153760 complement(939630..940091) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type lp : lipoprotein; hypothetical protein 940091 yehR 7153760 yehR Escherichia coli IAI39 hypothetical protein YP_002406913.1 939630 R 585057 CDS YP_002406914.1 218699285 7153759 complement(940216..942216) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 942216 yehQ 7153759 yehQ Escherichia coli IAI39 hypothetical protein YP_002406914.1 940216 R 585057 CDS YP_002406915.1 218699286 7153758 complement(942213..943349) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 943349 yehP 7153758 yehP Escherichia coli IAI39 hypothetical protein YP_002406915.1 942213 R 585057 CDS YP_002406916.1 218699287 7153757 complement(943342..945621) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 945621 yehM 7153757 yehM Escherichia coli IAI39 hypothetical protein YP_002406916.1 943342 R 585057 CDS YP_002406917.1 218699288 7153756 complement(945632..946720) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16428726; Product type pf : putative factor; putative ABC superfamily protein 946720 yehL 7153756 yehL Escherichia coli IAI39 putative ABC superfamily protein YP_002406917.1 945632 R 585057 CDS YP_002406918.1 218699289 7153755 complement(947424..947741) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 947741 yehK 7153755 yehK Escherichia coli IAI39 hypothetical protein YP_002406918.1 947424 R 585057 CDS YP_002406919.1 218699290 7153754 complement(947802..951440) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 951440 yehI 7153754 yehI Escherichia coli IAI39 hypothetical protein YP_002406919.1 947802 R 585057 CDS YP_002406920.1 218699291 7153753 951580..951855 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 951855 insA 7153753 insA Escherichia coli IAI39 IS1 repressor protein InsA YP_002406920.1 951580 D 585057 CDS YP_002406921.1 218699292 7151783 951774..952277 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 952277 insB 7151783 insB Escherichia coli IAI39 IS1 transposase InsAB' YP_002406921.1 951774 D 585057 CDS YP_002406922.1 218699293 7149666 complement(955451..956011) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2156810; hypothetical protein 956011 7149666 ECIAI39_0900 Escherichia coli IAI39 hypothetical protein YP_002406922.1 955451 R 585057 CDS YP_002406923.1 218699294 7149667 complement(956024..959830) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2156810; Product type ph : phenotype; putative molybdate metabolism protein 959830 7149667 ECIAI39_0901 Escherichia coli IAI39 putative molybdate metabolism protein YP_002406923.1 956024 R 585057 CDS YP_002406924.1 218699295 7149668 complement(959971..962004) 1 NC_011750.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 962004 metG 7149668 metG Escherichia coli IAI39 methionyl-tRNA synthetase YP_002406924.1 959971 R 585057 CDS YP_002406925.1 218699296 7152055 962136..963245 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91080852, 15601724, 2259334; Product type t : transporter; putative ATPase 963245 mrp 7152055 mrp Escherichia coli IAI39 putative ATPase YP_002406925.1 962136 D 585057 CDS YP_002406926.1 218699297 7152129 963508..963789 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 963789 yehE 7152129 yehE Escherichia coli IAI39 hypothetical protein YP_002406926.1 963508 D 585057 CDS YP_002406927.1 218699298 7153752 complement(963713..963895) 1 NC_011750.1 hypothetical protein 963895 7153752 ECIAI39_0905 Escherichia coli IAI39 hypothetical protein YP_002406927.1 963713 R 585057 CDS YP_002406928.1 218699299 7149669 964085..964627 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein 964627 yehD 7149669 yehD Escherichia coli IAI39 putative fimbrial-like adhesin protein YP_002406928.1 964085 D 585057 CDS YP_002406929.1 218699300 7153751 964708..965382 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative membrane-associated pilin chaperone 965382 yehC 7153751 yehC Escherichia coli IAI39 putative membrane-associated pilin chaperone YP_002406929.1 964708 D 585057 CDS YP_002406930.1 218699301 7153750 965398..967878 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 967878 yehB 7153750 yehB Escherichia coli IAI39 hypothetical protein YP_002406930.1 965398 D 585057 CDS YP_002406931.1 218699302 7153749 967894..968928 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative exported fimbrial-like adhesin protein 968928 yehA 7153749 yehA Escherichia coli IAI39 putative exported fimbrial-like adhesin protein YP_002406931.1 967894 D 585057 CDS YP_002406932.1 218699303 7153748 complement(969010..969528) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 969528 yohN 7153748 yohN Escherichia coli IAI39 hypothetical protein YP_002406932.1 969010 R 585057 CDS YP_002406933.1 218699304 7154460 complement(969567..970364) 1 NC_011750.1 membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA 970364 rncA 7154460 rncA Escherichia coli IAI39 nickel/cobalt efflux protein RcnA YP_002406933.1 969567 R 585057 CDS YP_002406934.1 218699305 7152654 970485..970757 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 970757 yohL 7152654 yohL Escherichia coli IAI39 hypothetical protein YP_002406934.1 970485 D 585057 CDS YP_002406935.1 218699306 7150523 970980..971768 1 NC_011750.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 971768 thiM 7150523 thiM Escherichia coli IAI39 hydroxyethylthiazole kinase YP_002406935.1 970980 D 585057 CDS YP_002406936.1 218699307 7152973 971765..972565 1 NC_011750.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 972565 thiD 7152973 thiD Escherichia coli IAI39 phosphomethylpyrimidine kinase YP_002406936.1 971765 D 585057 CDS YP_002406937.1 218699308 7152966 972630..973448 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-bound hydrolase 973448 yegX 7152966 yegX Escherichia coli IAI39 putative membrane-bound hydrolase YP_002406937.1 972630 D 585057 CDS YP_002406938.1 218699309 7153747 973500..974246 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 974246 yegW 7153747 yegW Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002406938.1 973500 D 585057 CDS YP_002406939.1 218699310 7153746 complement(974220..975185) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative kinase 975185 yegV 7153746 yegV Escherichia coli IAI39 putative kinase YP_002406939.1 974220 R 585057 CDS YP_002406940.1 218699311 7153745 complement(975182..976186) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative (phospho)hydrolase 976186 yegU 7153745 yegU Escherichia coli IAI39 putative (phospho)hydrolase YP_002406940.1 975182 R 585057 CDS YP_002406941.1 218699312 7153744 complement(976183..977460) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative hydrophilic substrate transporter; MFS superfamily 977460 yegT 7153744 yegT Escherichia coli IAI39 putative hydrophilic substrate transporter; MFS superfamily YP_002406941.1 976183 R 585057 CDS YP_002406942.1 218699313 7153743 977717..978769 1 NC_011750.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase 978769 fbaB 7153743 fbaB Escherichia coli IAI39 fructose-bisphosphate aldolase YP_002406942.1 977717 D 585057 CDS YP_002406943.1 218699314 7151280 978998..979852 1 NC_011750.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 979852 gatY 7151280 gatY Escherichia coli IAI39 tagatose-bisphosphate aldolase YP_002406943.1 978998 D 585057 CDS YP_002406944.1 218699315 7151491 979881..981143 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976750, 97113438, 7772602, 8932697; Product type e : enzyme; D-tagatose 1,6-bisphosphate aldolase 2 subunit 981143 gatZ 7151491 gatZ Escherichia coli IAI39 D-tagatose 1,6-bisphosphate aldolase 2 subunit YP_002406944.1 979881 D 585057 CDS YP_002406945.1 218699316 7151492 981153..981605 1 NC_011750.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIA 981605 gatA 7151492 gatA Escherichia coli IAI39 PTS system galactitol-specific transporter subunit IIA YP_002406945.1 981153 D 585057 CDS YP_002406946.1 218699317 7151486 981636..981920 1 NC_011750.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIB 981920 gatB 7151486 gatB Escherichia coli IAI39 PTS system galactitol-specific transporter subunit IIB YP_002406946.1 981636 D 585057 CDS YP_002406947.1 218699318 7151487 981924..983279 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76024805, 77192083, 97113438, 7772602; Product type t : transporter; galactitol-specific enzyme IIC component of PTS 983279 gatC 7151487 gatC Escherichia coli IAI39 galactitol-specific enzyme IIC component of PTS YP_002406947.1 981924 D 585057 CDS YP_002406948.1 218699319 7151488 983327..984367 1 NC_011750.1 Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase 984367 gatD 7151488 gatD Escherichia coli IAI39 galactitol-1-phosphate dehydrogenase YP_002406948.1 983327 D 585057 CDS YP_002406949.1 218699320 7151489 984467..985246 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7772602; Product type r : regulator; Galactitol utilization operon repressor 985246 gatR 7151489 gatR Escherichia coli IAI39 Galactitol utilization operon repressor YP_002406949.1 984467 D 585057 CDS YP_002406950.1 218699321 7151490 complement(985328..986227) 1 NC_011750.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase 986227 yegS 7151490 yegS Escherichia coli IAI39 lipid kinase YP_002406950.1 985328 R 585057 CDS YP_002406951.1 218699322 7153742 986640..986957 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 986957 yegR 7153742 yegR Escherichia coli IAI39 hypothetical protein YP_002406951.1 986640 D 585057 CDS YP_002406952.1 218699323 7152784 complement(987287..988648) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 988648 yegQ 7152784 yegQ Escherichia coli IAI39 putative peptidase YP_002406952.1 987287 R 585057 CDS YP_002406953.1 218699324 7153740 complement(988751..989047) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative plasmid stabilisation system protein 989047 7153740 ECIAI39_0931 Escherichia coli IAI39 putative plasmid stabilisation system protein YP_002406953.1 988751 R 585057 CDS YP_002406954.1 218699325 7149670 complement(989049..989345) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 989345 7149670 ECIAI39_0932 Escherichia coli IAI39 hypothetical protein YP_002406954.1 989049 R 585057 CDS YP_002406955.1 218699326 7149671 complement(989554..989886) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 989886 yegP 7149671 yegP Escherichia coli IAI39 hypothetical protein YP_002406955.1 989554 R 585057 CDS YP_002406956.1 218699327 7153739 complement(989926..990120) 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 990120 7153739 ECIAI39_0934 Escherichia coli IAI39 hypothetical protein YP_002406956.1 989926 R 585057 CDS YP_002406957.1 218699328 7149672 complement(990077..990799) 1 NC_011750.1 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; DNA-binding transcriptional regulator BaeR 990799 baeR 7149672 baeR Escherichia coli IAI39 DNA-binding transcriptional regulator BaeR YP_002406957.1 990077 R 585057 CDS YP_002406958.1 218699329 7150834 complement(990796..992199) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94110256, 8282725; Product type r : regulator; signal transduction histidine-protein kinase BaeS 992199 baeS 7150834 baeS Escherichia coli IAI39 signal transduction histidine-protein kinase BaeS YP_002406958.1 990796 R 585057 CDS YP_002406959.1 218699330 7150835 complement(992196..993611) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12107134, 21450803, 8282725; Product type t : transporter; multidrug efflux system protein MdtE 993611 mdtD 7150835 mdtD Escherichia coli IAI39 multidrug efflux system protein MdtE YP_002406959.1 992196 R 585057 CDS YP_002406960.1 218699331 7152031 complement(993612..996689) 1 NC_011750.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC 996689 mdtC 7152031 mdtC Escherichia coli IAI39 multidrug efflux system subunit MdtC YP_002406960.1 993612 R 585057 CDS YP_002406961.1 218699332 7152030 complement(996690..999812) 1 NC_011750.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtB 999812 mdtB 7152030 mdtB Escherichia coli IAI39 multidrug efflux system subunit MdtB YP_002406961.1 996690 R 585057 CDS YP_002406962.1 218699333 7152029 complement(999812..1001059) 1 NC_011750.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtA 1001059 mdtA 7152029 mdtA Escherichia coli IAI39 multidrug efflux system subunit MdtA YP_002406962.1 999812 R 585057 CDS YP_002406963.1 218699334 7152782 1002276..1002935 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1002935 yegL 7152782 yegL Escherichia coli IAI39 hypothetical protein YP_002406963.1 1002276 D 585057 CDS YP_002406964.1 218699335 7153738 1002932..1003693 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1003693 yegK 7153738 yegK Escherichia coli IAI39 hypothetical protein YP_002406964.1 1002932 D 585057 CDS YP_002406965.1 218699336 7153737 1003681..1005630 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1005630 yegI 7153737 yegI Escherichia coli IAI39 hypothetical protein YP_002406965.1 1003681 D 585057 CDS YP_002406966.1 218699337 7153736 complement(1005643..1006995) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 6094528, 7940673, 7984428; Product type pf : putative factor; putative chaperone 1006995 yegD 7153736 yegD Escherichia coli IAI39 putative chaperone YP_002406966.1 1005643 R 585057 CDS YP_002406967.1 218699338 7153733 1007138..1007986 1 NC_011750.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyl-adenine DNA glycosylase II 1007986 alkA 7153733 alkA Escherichia coli IAI39 3-methyl-adenine DNA glycosylase II YP_002406967.1 1007138 D 585057 CDS YP_002406968.1 218699339 7150713 complement(1008024..1011341) 1 NC_011750.1 contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction; putative sensor protein 1011341 yegE 7150713 yegE Escherichia coli IAI39 putative sensor protein YP_002406968.1 1008024 R 585057 CDS YP_002406969.1 218699340 7153734 1011659..1012300 1 NC_011750.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 1012300 udk 7153734 udk Escherichia coli IAI39 uridine kinase YP_002406969.1 1011659 D 585057 CDS YP_002406970.1 218699341 7153078 1012392..1012973 1 NC_011750.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 1012973 dcd 7153078 dcd Escherichia coli IAI39 deoxycytidine triphosphate deaminase YP_002406970.1 1012392 D 585057 CDS YP_002406971.1 218699342 7151090 1012995..1014848 1 NC_011750.1 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; putative assembly protein 1014848 asmA 7151090 asmA Escherichia coli IAI39 putative assembly protein YP_002406971.1 1012995 D 585057 CDS YP_002406972.1 218699343 7150801 complement(1014901..1015209) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1015209 7150801 ECIAI39_0950 Escherichia coli IAI39 hypothetical protein YP_002406972.1 1014901 R 585057 CDS YP_002406973.1 218699344 7149673 complement(1015181..1015519) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1015519 7149673 ECIAI39_0951 Escherichia coli IAI39 hypothetical protein YP_002406973.1 1015181 R 585057 CDS YP_002406974.1 218699345 7149674 complement(1015594..1017177) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 1017177 yegH 7149674 yegH Escherichia coli IAI39 hypothetical protein YP_002406974.1 1015594 R 585057 CDS YP_002406975.1 218699346 7153735 1017836..1018975 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15090537, 96326333, 8759852, 8763957; Product type lp : lipoprotein; capsular polysaccharide translocation lipoprotein 1018975 wza 7153735 wza Escherichia coli IAI39 capsular polysaccharide translocation lipoprotein YP_002406975.1 1017836 D 585057 CDS YP_002406976.1 218699347 7153162 1018981..1019424 1 NC_011750.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase 1019424 wzb 7153162 wzb Escherichia coli IAI39 tyrosine phosphatase YP_002406976.1 1018981 D 585057 CDS YP_002406977.1 218699348 7153163 1019427..1021589 1 NC_011750.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase 1021589 wzc 7153163 wzc Escherichia coli IAI39 tyrosine kinase YP_002406977.1 1019427 D 585057 CDS YP_002406978.1 218699349 7153164 1021682..1022521 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme; putative glycosyl transferase 1022521 wcaA 7153164 wcaA Escherichia coli IAI39 putative glycosyl transferase YP_002406978.1 1021682 D 585057 CDS YP_002406979.1 218699350 7153150 1022524..1023012 1 NC_011750.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; putative colanic acid biosynthesis acetyltransferase WcaB 1023012 wcaB 7153150 wcaB Escherichia coli IAI39 putative colanic acid biosynthesis acetyltransferase WcaB YP_002406979.1 1022524 D 585057 CDS YP_002406980.1 218699351 7153151 1023009..1024226 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme; putative glycosyl transferase 1024226 wcaC 7153151 wcaC Escherichia coli IAI39 putative glycosyl transferase YP_002406980.1 1023009 D 585057 CDS YP_002406981.1 218699352 7153152 1024201..1025418 1 NC_011750.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance; putative colanic acid biosynthesis protein 1025418 wcaD 7153152 wcaD Escherichia coli IAI39 putative colanic acid biosynthesis protein YP_002406981.1 1024201 D 585057 CDS YP_002406982.1 218699353 7153153 1025429..1026175 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11371548, 96326333, 8759852; Product type pe : putative enzyme; putative glycosyl transferase 1026175 wcaE 7153153 wcaE Escherichia coli IAI39 putative glycosyl transferase YP_002406982.1 1025429 D 585057 CDS YP_002406983.1 218699354 7153154 1026191..1026739 1 NC_011750.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); putative colanic acid biosynthesis acetyltransferase WcaF 1026739 wcaF 7153154 wcaF Escherichia coli IAI39 putative colanic acid biosynthesis acetyltransferase WcaF YP_002406983.1 1026191 D 585057 CDS YP_002406984.1 218699355 7153155 1026766..1027887 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20139699, 97400210, 10673432, 7815923, 8759852, 9257704, 14299611; Product type e : enzyme; GDP-D-mannose dehydratase, NAD(P)-binding 1027887 gmd 7153155 gmd Escherichia coli IAI39 GDP-D-mannose dehydratase, NAD(P)-binding YP_002406984.1 1026766 D 585057 CDS YP_002406985.1 218699356 7151562 1027890..1028855 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 98132401, 9862812, 7815923, 8759852, 9473059; Product type e : enzyme; bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase and GDP-4-dehydro-6-L-deoxygalactose reductase 1028855 fcl 7151562 fcl Escherichia coli IAI39 bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase and GDP-4-dehydro-6-L-deoxygalactose reductase YP_002406985.1 1027890 D 585057 CDS YP_002406986.1 218699357 7151282 1028858..1029337 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 10913267, 7592609, 7815923, 8759852; Product type e : enzyme; GDP-mannose mannosyl hydrolase 1029337 nudD 7151282 nudD Escherichia coli IAI39 GDP-mannose mannosyl hydrolase YP_002406986.1 1028858 D 585057 CDS YP_002406987.1 218699358 7152264 1029334..1030557 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15670885, 96326333; Product type pe : putative enzyme; putative glycosyl transferase 1030557 wcaI 7152264 wcaI Escherichia coli IAI39 putative glycosyl transferase YP_002406987.1 1029334 D 585057 CDS YP_002406988.1 218699359 7153156 1030560..1031996 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82100097, 85006781, 92048476, 93122523, 96326333, 7815923, 8759852; Product type e : enzyme; mannose-1-phosphate guanyltransferase 1031996 cpsB 7153156 cpsB Escherichia coli IAI39 mannose-1-phosphate guanyltransferase YP_002406988.1 1030560 D 585057 CDS YP_002406989.1 218699360 7150986 1032098..1033468 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106949, 96326333, 7815923, 8759852; Product type e : enzyme; phosphomannomutase 1033468 cpsG 7150986 cpsG Escherichia coli IAI39 phosphomannomutase YP_002406989.1 1032098 D 585057 CDS YP_002406990.1 218699361 7150987 1033523..1034917 1 NC_011750.1 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid; putative UDP-glucose lipid carrier transferase 1034917 wcaJ 7150987 wcaJ Escherichia coli IAI39 putative UDP-glucose lipid carrier transferase YP_002406990.1 1033523 D 585057 CDS YP_002406991.1 218699362 7153157 1034919..1036397 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 8759852; Product type pt : putative transporter; colanic acid exporter 1036397 wzxC 7153157 wzxC Escherichia coli IAI39 colanic acid exporter YP_002406991.1 1034919 D 585057 CDS YP_002406992.1 218699363 7153166 1036470..1037750 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333, 8759852, 11004393; Product type pe : putative enzyme; putative pyruvyl transferase 1037750 wcaK 7153166 wcaK Escherichia coli IAI39 putative pyruvyl transferase YP_002406992.1 1036470 D 585057 CDS YP_002406993.1 218699364 7153158 1037747..1038967 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme; putative glycosyl transferase 1038967 wcaL 7153158 wcaL Escherichia coli IAI39 putative glycosyl transferase YP_002406993.1 1037747 D 585057 CDS YP_002406994.1 218699365 7153159 1038978..1040372 1 NC_011750.1 WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid; putative colanic acid biosynthesis protein 1040372 wcaM 7153159 wcaM Escherichia coli IAI39 putative colanic acid biosynthesis protein YP_002406994.1 1038978 D 585057 CDS YP_002406995.1 218699366 7153160 1040547..1041440 1 NC_011750.1 together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalF 1041440 galF 7153160 galF Escherichia coli IAI39 UTP--glucose-1-phosphate uridylyltransferase subunit GalF YP_002406995.1 1040547 D 585057 CDS YP_002406996.1 218699367 7151471 1041813..1042898 1 NC_011750.1 NAD(P) binding; catalyzes the formation of dTDP-4-dehydro-6-deoxy-D-glucose from dTDP-glucose; dTDP-glucose 4,6 dehydratase 1042898 rmlB 7151471 rmlB Escherichia coli IAI39 dTDP-glucose 4,6 dehydratase YP_002406996.1 1041813 D 585057 CDS YP_002406997.1 218699368 7152647 1042898..1043797 1 NC_011750.1 with dTDP-4-dehydrorhamnose 3,5-epimerase forms a complex known as dTDP-L-rhamnose synthetase; catalyzes the reduction of dTDP-4-dehydro-6-deoxy-L-mannose to dTDP-L-rhamnose; dTDP-4-dehydrorhamnose reductase 1043797 rmlD 7152647 rmlD Escherichia coli IAI39 dTDP-4-dehydrorhamnose reductase YP_002406997.1 1042898 D 585057 CDS YP_002406998.1 218699369 7152649 1043856..1044734 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 5833803, 92120472, 94292435, 96032389, 7517390, 7517391, 14253441; Product type e : enzyme; glucose-1-phosphate thymidylyltransferase 1044734 rmlA 7152649 rmlA Escherichia coli IAI39 glucose-1-phosphate thymidylyltransferase YP_002406998.1 1043856 D 585057 CDS YP_002406999.1 218699370 7152646 1044739..1045284 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12949172, 15695810, 15932984; Product type e : enzyme; dTDP-6-deoxy-D-glucose-3,5 epimerase 1045284 rmlC 7152646 rmlC Escherichia coli IAI39 dTDP-6-deoxy-D-glucose-3,5 epimerase YP_002406999.1 1044739 D 585057 CDS YP_002407000.1 218699371 7152648 1045285..1046718 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17086202, 16816184; Product type e : enzyme; O-antigen flippase 1046718 wzx 7152648 wzx Escherichia coli IAI39 O-antigen flippase YP_002407000.1 1045285 D 585057 CDS YP_002407001.1 218699372 7153165 1046721..1047833 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10517601; Product type e : enzyme; dTDP-6-deoxy-D-xylo-4-hexulose aminotransferase 1047833 vioA 7153165 vioA Escherichia coli IAI39 dTDP-6-deoxy-D-xylo-4-hexulose aminotransferase YP_002407001.1 1046721 D 585057 CDS YP_002407002.1 218699373 7153127 1047835..1048413 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10517601; Product type e : enzyme; dTDP-viosamine N-acetyltransferase 1048413 vioB 7153127 vioB Escherichia coli IAI39 dTDP-viosamine N-acetyltransferase YP_002407002.1 1047835 D 585057 CDS YP_002407003.1 218699374 7153128 1048410..1049156 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10074083, 12591881; Product type e : enzyme; glycosyltransferase WbbA 1049156 wbbA 7153128 wbbA Escherichia coli IAI39 glycosyltransferase WbbA YP_002407003.1 1048410 D 585057 CDS YP_002407004.1 218699375 7153146 1049156..1049977 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15625181, 12591881; Product type e : enzyme; component WbbB of exported sugar polymer 1049977 wbbB 7153146 wbbB Escherichia coli IAI39 component WbbB of exported sugar polymer YP_002407004.1 1049156 D 585057 CDS YP_002407005.1 218699376 7153147 1049974..1051149 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17086202, 16816184; Product type e : enzyme; O-antigen polymerase Wzy 1051149 wzy 7153147 wzy Escherichia coli IAI39 O-antigen polymerase Wzy YP_002407005.1 1049974 D 585057 CDS YP_002407006.1 218699377 7153168 1051146..1052258 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15625181; Product type e : enzyme; glycosyltransferase WbbC 1052258 wbbC 7153168 wbbC Escherichia coli IAI39 glycosyltransferase WbbC YP_002407006.1 1051146 D 585057 CDS YP_002407007.1 218699378 7153148 1052248..1053075 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15625181; Product type e : enzyme; UDP-Gal:GlcNAc alpha-pyrophosphate-R beta 1, 3-galactosyltransferase 1053075 wbbD 7153148 wbbD Escherichia coli IAI39 UDP-Gal:GlcNAc alpha-pyrophosphate-R beta 1, 3-galactosyltransferase YP_002407007.1 1052248 D 585057 CDS YP_002407008.1 218699379 7153149 complement(1052518..1052607) 1 NC_011750.1 hypothetical protein 1052607 7153149 ECIAI39_0986 Escherichia coli IAI39 hypothetical protein YP_002407008.1 1052518 R 585057 CDS YP_002407009.1 218699380 7149675 1053072..1054496 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7677991; Product type e : enzyme; mannose-1-phosphate guanylyltransferase 1054496 manC 7149675 manC Escherichia coli IAI39 mannose-1-phosphate guanylyltransferase YP_002407009.1 1053072 D 585057 CDS YP_002407010.1 218699381 7152009 1054530..1055894 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106949, 96326333, 7815923, 8759852; Product type e : enzyme; phosphomannomutase 1055894 cpsG 7152009 cpsG Escherichia coli IAI39 phosphomannomutase YP_002407010.1 1054530 D 585057 CDS YP_002407011.1 218699382 7150988 1056058..1057464 1 NC_011750.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 1057464 gnd 7150988 gnd Escherichia coli IAI39 6-phosphogluconate dehydrogenase YP_002407011.1 1056058 D 585057 CDS YP_002407012.1 218699383 7151566 1057712..1058878 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150218, 96326333; Product type e : enzyme; UDP-glucose 6-dehydrogenase 1058878 ugd 7151566 ugd Escherichia coli IAI39 UDP-glucose 6-dehydrogenase YP_002407012.1 1057712 D 585057 CDS YP_002407013.1 218699384 7153080 1059024..1060004 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98241528; Product type r : regulator; regulator of length of O-antigen component of lipopolysaccharide chains 1060004 cld 7153080 cld Escherichia coli IAI39 regulator of length of O-antigen component of lipopolysaccharide chains YP_002407013.1 1059024 D 585057 CDS YP_002407014.1 218699385 7150962 complement(1060100..1060711) 1 NC_011750.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein 1060711 hisI 7150962 hisI Escherichia coli IAI39 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein YP_002407014.1 1060100 R 585057 CDS YP_002407015.1 218699386 7151653 complement(1060705..1061481) 1 NC_011750.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 1061481 hisF 7151653 hisF Escherichia coli IAI39 imidazole glycerol phosphate synthase subunit HisF YP_002407015.1 1060705 R 585057 CDS YP_002407016.1 218699387 7151650 complement(1061463..1062200) 1 NC_011750.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 1062200 hisA 7151650 hisA Escherichia coli IAI39 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase YP_002407016.1 1061463 R 585057 CDS YP_002407017.1 218699388 7151646 complement(1062200..1062790) 1 NC_011750.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 1062790 hisH 7151646 hisH Escherichia coli IAI39 imidazole glycerol phosphate synthase subunit HisH YP_002407017.1 1062200 R 585057 CDS YP_002407018.1 218699389 7151652 complement(1062790..1063857) 1 NC_011750.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 1063857 hisB 7151652 hisB Escherichia coli IAI39 imidazole glycerol-phosphate dehydratase/histidinol phosphatase YP_002407018.1 1062790 R 585057 CDS YP_002407019.1 218699390 7151647 complement(1063857..1064927) 1 NC_011750.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 1064927 hisC 7151647 hisC Escherichia coli IAI39 histidinol-phosphate aminotransferase YP_002407019.1 1063857 R 585057 CDS YP_002407020.1 218699391 7151648 complement(1064924..1066228) 1 NC_011750.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 1066228 hisD 7151648 hisD Escherichia coli IAI39 histidinol dehydrogenase YP_002407020.1 1064924 R 585057 CDS YP_002407021.1 218699392 7151649 complement(1066234..1067133) 1 NC_011750.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 1067133 hisG 7151649 hisG Escherichia coli IAI39 ATP phosphoribosyltransferase YP_002407021.1 1066234 R 585057 CDS YP_002407023.1 218699394 7151655 1067756..1068580 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative epimerase, with NAD(P)-binding Rossmann-fold domain 1068580 yeeZ 7151655 yeeZ Escherichia coli IAI39 putative epimerase, with NAD(P)-binding Rossmann-fold domain YP_002407023.1 1067756 D 585057 CDS YP_002407024.1 218699395 7153732 1068626..1069555 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1069555 yeeY 7153732 yeeY Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002407024.1 1068626 D 585057 CDS YP_002407025.1 218699396 7153731 1069822..1071180 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino-acid/amine transporter 1071180 yeeF 7153731 yeeF Escherichia coli IAI39 putative amino-acid/amine transporter YP_002407025.1 1069822 D 585057 CDS YP_002407026.1 218699397 7153709 1071359..1072417 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1072417 yeeE 7153709 yeeE Escherichia coli IAI39 hypothetical protein YP_002407026.1 1071359 D 585057 CDS YP_002407027.1 218699398 7153708 1072431..1072658 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1072658 yeeD 7153708 yeeD Escherichia coli IAI39 hypothetical protein YP_002407027.1 1072431 D 585057 CDS YP_002407028.1 218699399 7153707 complement(1072701..1074128) 1 NC_011750.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 1074128 sbcB 7153707 sbcB Escherichia coli IAI39 exonuclease I YP_002407028.1 1072701 R 585057 CDS YP_002407029.1 218699400 7152804 1074337..1075503 1 NC_011750.1 removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 1075503 dacD 7152804 dacD Escherichia coli IAI39 D-alanyl-D-alanine carboxypeptidase YP_002407029.1 1074337 D 585057 CDS YP_002407030.1 218699401 7151079 complement(1075630..1076850) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative transposase 1076850 7151079 ECIAI39_1007 Escherichia coli IAI39 putative transposase YP_002407030.1 1075630 R 585057 CDS YP_002407031.1 218699402 7149676 complement(1076869..1077387) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1077387 7149676 ECIAI39_1008 Escherichia coli IAI39 hypothetical protein YP_002407031.1 1076869 R 585057 CDS YP_002407032.1 218699403 7149677 1077515..1077988 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11850398, 9442027, 8709849; Product type r : regulator; DNA gyrase inhibitor 1077988 sbmC 7149677 sbmC Escherichia coli IAI39 DNA gyrase inhibitor YP_002407032.1 1077515 D 585057 CDS YP_002407033.1 218699404 7152808 1078186..1079244 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1079244 yeeA 7152808 yeeA Escherichia coli IAI39 hypothetical protein YP_002407033.1 1078186 D 585057 CDS YP_002407034.1 218699405 7153706 1079350..1079745 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1079745 yeeX 7153706 yeeX Escherichia coli IAI39 hypothetical protein YP_002407034.1 1079350 D 585057 CDS YP_002407035.1 218699406 7153730 complement(1080643..1080837) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1080837 yeeW 7153730 yeeW Escherichia coli IAI39 hypothetical protein YP_002407035.1 1080643 R 585057 CDS YP_002407036.1 218699407 7153721 complement(1081738..1081959) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1081959 yeeT 7153721 yeeT Escherichia coli IAI39 hypothetical protein YP_002407036.1 1081738 R 585057 CDS YP_002407037.1 218699408 7153718 complement(1082022..1082498) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : putative factor; putative DNA repair protein; CP4-44 prophage 1082498 yeeS 7153718 yeeS Escherichia coli IAI39 putative DNA repair protein; CP4-44 prophage YP_002407037.1 1082022 R 585057 CDS YP_002407038.1 218699409 7153715 complement(1082513..1082992) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7519596; Product type h : extrachromosomal origin; putative antirestriction protein of plasmid origin 1082992 7153715 ECIAI39_1017 Escherichia coli IAI39 putative antirestriction protein of plasmid origin YP_002407038.1 1082513 R 585057 CDS YP_002407039.1 218699410 7149678 complement(1083074..1083895) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1083895 7149678 ECIAI39_1018 Escherichia coli IAI39 hypothetical protein YP_002407039.1 1083074 R 585057 CDS YP_002407040.1 218699411 7149679 complement(1084289..1084771) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1084771 7149679 ECIAI39_1019 Escherichia coli IAI39 hypothetical protein YP_002407040.1 1084289 R 585057 CDS YP_002407041.1 218699412 7149680 complement(1084913..1085029) 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1085029 7149680 ECIAI39_1020 Escherichia coli IAI39 hypothetical protein YP_002407041.1 1084913 R 585057 CDS YP_002407042.1 218699413 7149681 complement(1085216..1085440) 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1085440 7149681 ECIAI39_1021 Escherichia coli IAI39 hypothetical protein YP_002407042.1 1085216 R 585057 CDS YP_002407043.1 218699414 7149682 complement(1085430..1085822) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1085822 7149682 ECIAI39_1022 Escherichia coli IAI39 hypothetical protein YP_002407043.1 1085430 R 585057 CDS YP_002407044.1 218699415 7149683 complement(1085909..1086979) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1086979 7149683 ECIAI39_1023 Escherichia coli IAI39 hypothetical protein YP_002407044.1 1085909 R 585057 CDS YP_002407045.1 218699416 7149684 complement(1086976..1087311) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1087311 7149684 ECIAI39_1024 Escherichia coli IAI39 hypothetical protein YP_002407045.1 1086976 R 585057 CDS YP_002407046.1 218699417 7149685 complement(1087336..1087881) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1087881 7149685 ECIAI39_1025 Escherichia coli IAI39 hypothetical protein YP_002407046.1 1087336 R 585057 CDS YP_002407047.1 218699418 7149686 complement(1087878..1090274) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1090274 7149686 ECIAI39_1026 Escherichia coli IAI39 hypothetical protein YP_002407047.1 1087878 R 585057 CDS YP_002407048.1 218699419 7149687 complement(1090492..1091427) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative GTP-binding domain 1091427 7149687 ECIAI39_1027 Escherichia coli IAI39 putative GTP-binding domain YP_002407048.1 1090492 R 585057 CDS YP_002407049.1 218699420 7149688 complement(1091449..1092627) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1092627 7149688 ECIAI39_1028 Escherichia coli IAI39 hypothetical protein YP_002407049.1 1091449 R 585057 CDS YP_002407051.1 218699422 7149690 complement(1094249..1094689) 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS3 family 1094689 7149690 ECIAI39_1030 Escherichia coli IAI39 transposase ORF B (fragment), IS3 family YP_002407051.1 1094249 R 585057 CDS YP_002407052.1 218699423 7150526 complement(1094818..1096341) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9353259, 10413481; Product type e : enzyme; Group II intron-encoded reverse transcriptase/maturase 1096341 7150526 ECIAI39_1031 Escherichia coli IAI39 Group II intron-encoded reverse transcriptase/maturase YP_002407052.1 1094818 R 585057 CDS YP_002407053.1 218699424 7149693 complement(1097385..1097732) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS3 family 1097732 7149693 ECIAI39_1033 Escherichia coli IAI39 transposase ORF A, IS3 family YP_002407053.1 1097385 R 585057 CDS YP_002407054.1 218699425 7149695 complement(1098611..1099429) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 1099429 7149695 ECIAI39_1035 Escherichia coli IAI39 transposase ORF B, IS600 YP_002407054.1 1098611 R 585057 CDS YP_002407055.1 218699426 7149696 complement(1099465..1099767) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS600 1099767 insM 7149696 insM Escherichia coli IAI39 transposase ORF A, IS600 YP_002407055.1 1099465 R 585057 CDS YP_002407056.1 218699427 7149697 complement(1100090..1101055) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1101055 7149697 ECIAI39_1038 Escherichia coli IAI39 hypothetical protein YP_002407056.1 1100090 R 585057 CDS YP_002407057.1 218699428 7149698 complement(1101109..1101867) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1101867 7149698 ECIAI39_1039 Escherichia coli IAI39 hypothetical protein YP_002407057.1 1101109 R 585057 CDS YP_002407058.1 218699429 7149699 complement(1101881..1103095) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative carbohydrate kinase 1103095 7149699 ECIAI39_1040 Escherichia coli IAI39 putative carbohydrate kinase YP_002407058.1 1101881 R 585057 CDS YP_002407059.1 218699430 7149700 complement(1103281..1103397) 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 1103397 7149700 ECIAI39_1041 Escherichia coli IAI39 hypothetical protein YP_002407059.1 1103281 R 585057 CDS YP_002407060.1 218699431 7149701 complement(1103876..1104607) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1104607 yaiO 7149701 yaiO Escherichia coli IAI39 hypothetical protein YP_002407060.1 1103876 R 585057 CDS YP_002407061.1 218699432 7153263 complement(1104650..1105174) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleotidyl transferase 1105174 yaiX 7153263 yaiX Escherichia coli IAI39 putative nucleotidyl transferase YP_002407061.1 1104650 R 585057 CDS YP_002407062.1 218699433 7153271 complement(1105209..1106405) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated glycosyltransferase 1106405 yaiP 7153271 yaiP Escherichia coli IAI39 putative membrane-associated glycosyltransferase YP_002407062.1 1105209 R 585057 CDS YP_002407063.1 218699434 7153265 complement(1106419..1107129) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1107129 yaiS 7153265 yaiS Escherichia coli IAI39 hypothetical protein YP_002407063.1 1106419 R 585057 CDS YP_002407064.1 218699435 7153267 1108148..1109332 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator 1109332 ibrA 7153267 ibrA Escherichia coli IAI39 immunoglobulin-binding regulator YP_002407064.1 1108148 D 585057 CDS YP_002407065.1 218699436 7151747 1109516..1109842 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 1109842 7151747 ECIAI39_1047 Escherichia coli IAI39 transposase ORF A, IS629 YP_002407065.1 1109516 D 585057 CDS YP_002407066.1 218699437 7149702 1109839..1110729 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 1110729 7149702 ECIAI39_1048 Escherichia coli IAI39 transposase ORF B, IS629 YP_002407066.1 1109839 D 585057 CDS YP_002407067.1 218699438 7151749 complement(1111646..1113820) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane receptor for iron compound or colicin 1113820 7151749 ECIAI39_1050 Escherichia coli IAI39 putative outer membrane receptor for iron compound or colicin YP_002407067.1 1111646 R 585057 CDS YP_002407068.1 218699439 7149704 1114354..1114443 1 NC_011750.1 hypothetical protein 1114443 7149704 ECIAI39_1051 Escherichia coli IAI39 hypothetical protein YP_002407068.1 1114354 D 585057 CDS YP_002407069.1 218699440 7149705 1114836..1115000 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1115000 7149705 ECIAI39_1052 Escherichia coli IAI39 hypothetical protein YP_002407069.1 1114836 D 585057 CDS YP_002407070.1 218699441 7149706 1115465..1116010 1 NC_011750.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase 1116010 cobU 7149706 cobU Escherichia coli IAI39 adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase YP_002407070.1 1115465 D 585057 CDS YP_002407071.1 218699442 7150979 1116007..1116750 1 NC_011750.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 1116750 cobS 7150979 cobS Escherichia coli IAI39 cobalamin synthase YP_002407071.1 1116007 D 585057 CDS YP_002407072.1 218699443 7150977 1116762..1117841 1 NC_011750.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 1117841 cobT 7150977 cobT Escherichia coli IAI39 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase YP_002407072.1 1116762 D 585057 CDS YP_002407073.1 218699444 7150978 1117906..1118838 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9298646; hypothetical protein 1118838 erfK 7150978 erfK Escherichia coli IAI39 hypothetical protein YP_002407073.1 1117906 D 585057 CDS YP_002407074.1 218699445 7150623 1119296..1120213 1 NC_011750.1 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator 1120213 nac 7150623 nac Escherichia coli IAI39 nitrogen assimilation transcriptional regulator YP_002407074.1 1119296 D 585057 CDS YP_002407075.1 218699446 7152164 1120315..1121265 1 NC_011750.1 LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl 1121265 cbl 7152164 cbl Escherichia coli IAI39 transcriptional regulator Cbl YP_002407075.1 1120315 D 585057 CDS YP_002407076.1 218699447 7150622 1121386..1123026 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16042411; Product type pt : putative transporter; hypothetical protein 1123026 yeeO 7150622 yeeO Escherichia coli IAI39 hypothetical protein YP_002407076.1 1121386 D 585057 CDS YP_002407077.1 218699448 7150638 complement(1123643..1124359) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1124359 yeeN 7150638 yeeN Escherichia coli IAI39 hypothetical protein YP_002407077.1 1123643 R 585057 CDS YP_002407078.1 218699449 7153713 complement(1124702..1126156) 1 NC_011750.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 1126156 amn 7153713 amn Escherichia coli IAI39 AMP nucleosidase YP_002407078.1 1124702 R 585057 CDS YP_002407079.1 218699450 7150728 complement(1126258..1127574) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 5332864, 9524262; Product type t : transporter; shikimate transporter 1127574 shiA 7150728 shiA Escherichia coli IAI39 shikimate transporter YP_002407079.1 1126258 R 585057 CDS YP_002407080.1 218699451 7152850 1127826..1128941 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1128941 7152850 ECIAI39_1065 Escherichia coli IAI39 hypothetical protein YP_002407080.1 1127826 D 585057 CDS YP_002407081.1 218699452 7153712 complement(1131063..1131233) 1 NC_011750.1 hypothetical protein 1131233 7153712 ECIAI39_1068 Escherichia coli IAI39 hypothetical protein YP_002407081.1 1131063 R 585057 CDS YP_002407082.1 218699453 7149708 complement(1131160..1131975) 1 NC_011750.1 hypothetical protein 1131975 7149708 ECIAI39_1069 Escherichia coli IAI39 hypothetical protein YP_002407082.1 1131160 R 585057 CDS YP_002407083.1 218699454 7149709 complement(1132569..1134590) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7896707, 7984105; Product type rc : receptor; yersiniabactin/pesticin outer membrane receptor (IRPC) 1134590 fyuA 7149709 fyuA Escherichia coli IAI39 yersiniabactin/pesticin outer membrane receptor (IRPC) YP_002407083.1 1132569 R 585057 CDS YP_002407084.1 218699455 7151459 complement(1134721..1136298) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9818149, 11927258, 9709002; Product type e : enzyme; salicyl-AMP ligase YbtE 1136298 irp 7151459 irp Escherichia coli IAI39 salicyl-AMP ligase YbtE YP_002407084.1 1134721 R 585057 CDS YP_002407085.1 218699456 7151837 complement(1136302..1137105) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative thioesterase YbtT 1137105 irp 7151837 irp Escherichia coli IAI39 putative thioesterase YbtT YP_002407085.1 1136302 R 585057 CDS YP_002407086.1 218699457 7151838 complement(1137102..1138262) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11927258; Product type e : enzyme; Thiazolinyl-S-HMWP1 reductase YbtU 1138262 irp 7151838 irp Escherichia coli IAI39 Thiazolinyl-S-HMWP1 reductase YbtU YP_002407086.1 1137102 R 585057 CDS YP_002407087.1 218699458 7151839 complement(1138199..1147690) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15719346, 15582399, 11927258; Product type e : enzyme; High-molecular-weight nonribosomal peptide/polyketide synthetase 1 1147690 irp 7151839 irp Escherichia coli IAI39 High-molecular-weight nonribosomal peptide/polyketide synthetase 1 YP_002407087.1 1138199 R 585057 CDS YP_002407088.1 218699459 7151840 complement(1147778..1153903) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15719346, 15582399, 8366034, 11927258, 9709002; Product type e : enzyme; High-molecular-weight nonribosomal peptide/polyketide synthetase 2 1153903 irp 7151840 irp Escherichia coli IAI39 High-molecular-weight nonribosomal peptide/polyketide synthetase 2 YP_002407088.1 1147778 R 585057 CDS YP_002407089.1 218699460 7151841 complement(1154076..1155035) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8930916; Product type r : regulator; AraC family transcriptional regulator 1155035 ybtA 7151841 ybtA Escherichia coli IAI39 AraC family transcriptional regulator YP_002407089.1 1154076 R 585057 CDS YP_002407090.1 218699461 7153392 1155202..1157004 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10231486, 11320115; Product type t : transporter; yersiniabactin-iron ABC transporter permease ATP-binding protein YbtP 1157004 irp 7153392 irp Escherichia coli IAI39 yersiniabactin-iron ABC transporter permease ATP-binding protein YbtP YP_002407090.1 1155202 D 585057 CDS YP_002407091.1 218699462 7151842 1156964..1158793 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10231486, 11320115; Product type t : transporter; yersiniabactin-iron ABC transporter permease ATP-binding protein YbtQ 1158793 irp 7151842 irp Escherichia coli IAI39 yersiniabactin-iron ABC transporter permease ATP-binding protein YbtQ YP_002407091.1 1156964 D 585057 CDS YP_002407092.1 218699463 7151843 1158786..1160066 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; yersiniabactin-iron transporter permease YbtX 1160066 irp 7151843 irp Escherichia coli IAI39 yersiniabactin-iron transporter permease YbtX YP_002407092.1 1158786 D 585057 CDS YP_002407093.1 218699464 7151844 1160094..1161398 1 NC_011750.1 catalyzes the conversion of chorismate to salicylate in the biosynthesis of the siderophore yersiniabactin; salicylate synthase Irp9 1161398 irp 7151844 irp Escherichia coli IAI39 salicylate synthase Irp9 YP_002407093.1 1160094 D 585057 CDS YP_002407094.1 218699465 7151845 complement(1161592..1162854) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; integrase 1162854 int 7151845 int Escherichia coli IAI39 integrase YP_002407094.1 1161592 R 585057 CDS YP_002407095.1 218699466 7150621 complement(1163192..1163989) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1163989 yeeI 7150621 yeeI Escherichia coli IAI39 hypothetical protein YP_002407095.1 1163192 R 585057 CDS YP_002407096.1 218699467 7150552 complement(1164842..1165492) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12077457, 12480884, 12909634, 9579078; hypothetical protein 1165492 yodA 7150552 yodA Escherichia coli IAI39 hypothetical protein YP_002407096.1 1164842 R 585057 CDS YP_002407097.1 218699468 7154450 complement(1165750..1166385) 1 NC_011750.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; putative sulfite oxidase subunit YedZ 1166385 yedZ 7154450 yedZ Escherichia coli IAI39 putative sulfite oxidase subunit YedZ YP_002407097.1 1165750 R 585057 CDS YP_002407098.1 218699469 7153705 complement(1166386..1167390) 1 NC_011750.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; putative sulfite oxidase subunit YedY 1167390 yedY 7153705 yedY Escherichia coli IAI39 putative sulfite oxidase subunit YedY YP_002407098.1 1166386 R 585057 CDS YP_002407099.1 218699470 7153704 complement(1167499..1167912) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1167912 yedX 7153704 yedX Escherichia coli IAI39 hypothetical protein YP_002407099.1 1167499 R 585057 CDS YP_002407100.1 218699471 7153703 1168045..1168716 1 NC_011750.1 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW 1168716 yedW 7153703 yedW Escherichia coli IAI39 transcriptional regulatory protein YedW YP_002407100.1 1168045 D 585057 CDS YP_002407101.1 218699472 7153702 1168716..1170074 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15522865; Product type rc : receptor; sensory kinase in two-component regulatory system with YedW 1170074 yedV 7153702 yedV Escherichia coli IAI39 sensory kinase in two-component regulatory system with YedW YP_002407101.1 1168716 D 585057 CDS YP_002407102.1 218699473 7153701 complement(1170182..1171033) 1 NC_011750.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 1171033 hchA 7153701 hchA Escherichia coli IAI39 chaperone protein HchA YP_002407102.1 1170182 R 585057 CDS YP_002407103.1 218699474 7151614 complement(1171629..1172756) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type m : membrane component; outer membrane protein N (porin) 1172756 7151614 ECIAI39_1091 Escherichia coli IAI39 outer membrane protein N (porin) YP_002407103.1 1171629 R 585057 CDS YP_002407104.1 218699475 7149710 complement(1171955..1172179) 1 NC_011750.1 hypothetical protein 1172179 7149710 ECIAI39_1092 Escherichia coli IAI39 hypothetical protein YP_002407104.1 1171955 R 585057 CDS YP_002407105.1 218699476 7152741 1173253..1173618 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1173618 yedR 7152741 yedR Escherichia coli IAI39 hypothetical protein YP_002407105.1 1173253 D 585057 CDS YP_002407106.1 218699477 7153700 1173658..1174353 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pe : putative enzyme; hypothetical protein 1174353 yedJ 7153700 yedJ Escherichia coli IAI39 hypothetical protein YP_002407106.1 1173658 D 585057 CDS YP_002407107.1 218699478 7153694 1174420..1175838 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90280700, 91285397, 93367813, 2198248, 2527357; Product type e : enzyme; DNA cytosine methylase 1175838 dcm 7153694 dcm Escherichia coli IAI39 DNA cytosine methylase YP_002407107.1 1174420 D 585057 CDS YP_002407108.1 218699479 7151091 1175819..1176289 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330522, 92049708, 94049122, 10360178, 10612397, 10871403, 2527357; Product type e : enzyme; DNA mismatch endonuclease of very short patch repair 1176289 vsr 7151091 vsr Escherichia coli IAI39 DNA mismatch endonuclease of very short patch repair YP_002407108.1 1175819 D 585057 CDS YP_002407109.1 218699480 7153131 complement(1176278..1177198) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1177198 yedA 7153131 yedA Escherichia coli IAI39 hypothetical protein YP_002407109.1 1176278 R 585057 CDS YP_002407110.1 218699481 7153689 1177371..1178288 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1178288 yedI 7153689 yedI Escherichia coli IAI39 hypothetical protein YP_002407110.1 1177371 D 585057 CDS YP_002407111.1 218699482 7153693 1178367..1178549 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1178549 yodC 7153693 yodC Escherichia coli IAI39 hypothetical protein YP_002407111.1 1178367 D 585057 CDS YP_002407112.1 218699483 7154451 1178611..1178799 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1178799 7154451 ECIAI39_1100 Escherichia coli IAI39 hypothetical protein YP_002407112.1 1178611 D 585057 CDS YP_002407113.1 218699484 7149712 1178720..1180414 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16530465; Product type pe : putative enzyme; putative diguanylate cyclase 1180414 yedQ 7149712 yedQ Escherichia coli IAI39 putative diguanylate cyclase YP_002407113.1 1178720 D 585057 CDS YP_002407114.1 218699485 7153699 complement(1180411..1181226) 1 NC_011750.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate; mannosyl-3-phosphoglycerate phosphatase 1181226 yedP 7153699 yedP Escherichia coli IAI39 mannosyl-3-phosphoglycerate phosphatase YP_002407114.1 1180411 R 585057 CDS YP_002407115.1 218699486 7151182 complement(1181523..1181750) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1181750 yodD 7151182 yodD Escherichia coli IAI39 hypothetical protein YP_002407115.1 1181523 R 585057 CDS YP_002407116.1 218699487 7151184 1181913..1182101 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 96324407, 7534408; hypothetical protein 1182101 dsrB 7151184 dsrB Escherichia coli IAI39 hypothetical protein YP_002407116.1 1181913 D 585057 CDS YP_002407117.1 218699488 7151183 complement(1182145..1182768) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14514676, 14766922, 20167175, 90130299, 91154130, 92048476, 9882673, 7534408; Product type r : regulator; DNA-binding transcriptional activator, co-regulator with RcsB 1182768 rcsA 7151183 rcsA Escherichia coli IAI39 DNA-binding transcriptional activator, co-regulator with RcsB YP_002407117.1 1182145 R 585057 CDS YP_002407118.1 218699489 7152577 complement(1183058..1183777) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1482109, 92407478, 94110225; Product type pt : putative transporter; flagellar export pore protein 1183777 fliR 7152577 fliR Escherichia coli IAI39 flagellar export pore protein YP_002407118.1 1183058 R 585057 CDS YP_002407119.1 218699490 7151387 complement(1183852..1184121) 1 NC_011750.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ 1184121 fliQ 7151387 fliQ Escherichia coli IAI39 flagellar biosynthesis protein FliQ YP_002407119.1 1183852 R 585057 CDS YP_002407120.1 218699491 7151386 complement(1184131..1184868) 1 NC_011750.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 1184868 fliP 7151386 fliP Escherichia coli IAI39 flagellar biosynthesis protein FliP YP_002407120.1 1184131 R 585057 CDS YP_002407121.1 218699492 7151385 complement(1184868..1185233) 1 NC_011750.1 with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO 1185233 fliO 7151385 fliO Escherichia coli IAI39 flagellar biosynthesis protein FliO YP_002407121.1 1184868 R 585057 CDS YP_002407122.1 218699493 7151384 complement(1185236..1185649) 1 NC_011750.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN 1185649 fliN 7151384 fliN Escherichia coli IAI39 flagellar motor switch protein FliN YP_002407122.1 1185236 R 585057 CDS YP_002407123.1 218699494 7151383 complement(1185646..1186650) 1 NC_011750.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 1186650 fliM 7151383 fliM Escherichia coli IAI39 flagellar motor switch protein FliM YP_002407123.1 1185646 R 585057 CDS YP_002407124.1 218699495 7151382 complement(1186655..1187119) 1 NC_011750.1 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body-associated protein FliL 1187119 fliL 7151382 fliL Escherichia coli IAI39 flagellar basal body-associated protein FliL YP_002407124.1 1186655 R 585057 CDS YP_002407125.1 218699496 7151381 complement(1187224..1188351) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1482109, 8631687; Product type s : structure; flagellar hook-length control protein 1188351 fliK 7151381 fliK Escherichia coli IAI39 flagellar hook-length control protein YP_002407125.1 1187224 R 585057 CDS YP_002407126.1 218699497 7151380 complement(1188348..1188791) 1 NC_011750.1 rod/hook and filament chaperone; flagellar biosynthesis chaperone 1188791 fliJ 7151380 fliJ Escherichia coli IAI39 flagellar biosynthesis chaperone YP_002407126.1 1188348 R 585057 CDS YP_002407127.1 218699498 7151379 complement(1188810..1190183) 1 NC_011750.1 involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 1190183 fliI 7151379 fliI Escherichia coli IAI39 flagellum-specific ATP synthase YP_002407127.1 1188810 R 585057 CDS YP_002407128.1 218699499 7151378 complement(1190183..1190869) 1 NC_011750.1 binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 1190869 fliH 7151378 fliH Escherichia coli IAI39 flagellar assembly protein H YP_002407128.1 1190183 R 585057 CDS YP_002407129.1 218699500 7151375 1191263..1191589 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 1191589 7151375 ECIAI39_1118 Escherichia coli IAI39 transposase ORF A, IS629 YP_002407129.1 1191263 D 585057 CDS YP_002407130.1 218699501 7149713 1191586..1192476 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 1192476 7149713 ECIAI39_1119 Escherichia coli IAI39 transposase ORF B, IS629 YP_002407130.1 1191586 D 585057 CDS YP_002407131.1 218699502 7151376 complement(1193163..1194821) 1 NC_011750.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein 1194821 fliF 7151376 fliF Escherichia coli IAI39 flagellar MS-ring protein YP_002407131.1 1193163 R 585057 CDS YP_002407132.1 218699503 7151374 1195036..1195350 1 NC_011750.1 forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE 1195350 fliE 7151374 fliE Escherichia coli IAI39 flagellar hook-basal body protein FliE YP_002407132.1 1195036 D 585057 CDS YP_002407133.1 218699504 7151373 complement(1195755..1196234) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyltransferase 1196234 yedL 7151373 yedL Escherichia coli IAI39 putative acyltransferase YP_002407133.1 1195755 R 585057 CDS YP_002407134.1 218699505 7153696 complement(1196345..1197013) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1197013 yedK 7153696 yedK Escherichia coli IAI39 hypothetical protein YP_002407134.1 1196345 R 585057 CDS YP_002407135.1 218699506 7153695 complement(1197122..1197355) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1197355 yedF 7153695 yedF Escherichia coli IAI39 hypothetical protein YP_002407135.1 1197122 R 585057 CDS YP_002407136.1 218699507 7153692 complement(1197352..1198557) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; putative inner membrane protein 1198557 yedE 7153692 yedE Escherichia coli IAI39 putative inner membrane protein YP_002407136.1 1197352 R 585057 CDS YP_002407137.1 218699508 7153691 1198744..1199157 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1199157 yedD 7153691 yedD Escherichia coli IAI39 hypothetical protein YP_002407137.1 1198744 D 585057 CDS YP_002407138.1 218699509 7153690 complement(1199191..1200678) 1 NC_011750.1 converts 1,4-alpha-D-glucans to maltodextrin; cytoplasmic alpha-amylase 1200678 amyA 7153690 amyA Escherichia coli IAI39 cytoplasmic alpha-amylase YP_002407138.1 1199191 R 585057 CDS YP_002407139.1 218699510 7150735 complement(1200756..1201121) 1 NC_011750.1 binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT 1201121 fliT 7150735 fliT Escherichia coli IAI39 flagellar biosynthesis protein FliT YP_002407139.1 1200756 R 585057 CDS YP_002407140.1 218699511 7151389 complement(1201121..1201531) 1 NC_011750.1 flagellin specific chaperone; flagellar protein FliS 1201531 fliS 7151389 fliS Escherichia coli IAI39 flagellar protein FliS YP_002407140.1 1201121 R 585057 CDS YP_002407141.1 218699512 7151388 complement(1201556..1202962) 1 NC_011750.1 involved in flagellin assembly; flagellar capping protein 1202962 fliD 7151388 fliD Escherichia coli IAI39 flagellar capping protein YP_002407141.1 1201556 R 585057 CDS YP_002407142.1 218699513 7151372 1203228..1204934 1 NC_011750.1 structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes; flagellin 1204934 fliC 7151372 fliC Escherichia coli IAI39 flagellin YP_002407142.1 1203228 D 585057 CDS YP_002407143.1 218699514 7151371 1205100..1205819 1 NC_011750.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor 1205819 fliA 7151371 fliA Escherichia coli IAI39 flagellar biosynthesis sigma factor YP_002407143.1 1205100 D 585057 CDS YP_002407144.1 218699515 7151370 1205865..1206416 1 NC_011750.1 expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence; flagella biosynthesis protein FliZ 1206416 fliZ 7151370 fliZ Escherichia coli IAI39 flagella biosynthesis protein FliZ YP_002407144.1 1205865 D 585057 CDS YP_002407145.1 218699516 7151391 1206504..1207304 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96125225, 8450713, 8774726, 9298646, 9740056; Product type t : transporter; cystine transporter subunit 1207304 fliY 7151391 fliY Escherichia coli IAI39 cystine transporter subunit YP_002407145.1 1206504 D 585057 CDS YP_002407146.1 218699517 7151390 1207409..1208395 1 NC_011750.1 catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase 1208395 yedO 7151390 yedO Escherichia coli IAI39 D-cysteine desulfhydrase YP_002407146.1 1207409 D 585057 CDS YP_002407147.1 218699518 7153697 1208410..1209078 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease 1209078 yecS 7153697 yecS Escherichia coli IAI39 putative ABC transporter permease YP_002407147.1 1208410 D 585057 CDS YP_002407148.1 218699519 7153688 1209075..1209827 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino-acid ABC transporter ATP-binding protein YecC 1209827 yecC 7153688 yecC Escherichia coli IAI39 putative amino-acid ABC transporter ATP-binding protein YecC YP_002407148.1 1209075 D 585057 CDS YP_002407149.1 218699520 7153675 1210057..1210779 1 NC_011750.1 regulates genes involved in cell division; DNA-binding transcriptional activator SdiA 1210779 sdiA 7153675 sdiA Escherichia coli IAI39 DNA-binding transcriptional activator SdiA YP_002407149.1 1210057 D 585057 CDS YP_002407150.1 218699521 7152817 complement(1210847..1211071) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3515318, 7567469; hypothetical protein 1211071 yecF 7152817 yecF Escherichia coli IAI39 hypothetical protein YP_002407150.1 1210847 R 585057 CDS YP_002407151.1 218699522 7153678 1211530..1212186 1 NC_011750.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator 1212186 uvrY 7153678 uvrY Escherichia coli IAI39 response regulator YP_002407151.1 1211530 D 585057 CDS YP_002407152.1 218699523 7153117 1212183..1214015 1 NC_011750.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1214015 uvrC 7153117 uvrC Escherichia coli IAI39 excinuclease ABC subunit C YP_002407152.1 1212183 D 585057 CDS YP_002407153.1 218699524 7153115 1214072..1214620 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 381294, 7007311, 94253011, 1323047, 3003065, 8917447; Product type e : enzyme; phosphatidylglycerophosphate synthetase 1214620 pgsA 7153115 pgsA Escherichia coli IAI39 phosphatidylglycerophosphate synthetase YP_002407153.1 1214072 D 585057 CDS YP_002407154.1 218699525 7150555 1215270..1215935 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1215935 yecA 7150555 yecA Escherichia coli IAI39 hypothetical protein YP_002407154.1 1215270 D 585057 CDS YP_002407155.1 218699526 7153674 complement(1215985..1217196) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89008121, 2022620; Product type t : transporter; tyrosine transporter 1217196 tyrP 7153674 tyrP Escherichia coli IAI39 tyrosine transporter YP_002407155.1 1215985 R 585057 CDS YP_002407156.1 218699527 7153064 1217387..1217626 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1217626 yecH 7153064 yecH Escherichia coli IAI39 hypothetical protein YP_002407156.1 1217387 D 585057 CDS YP_002407157.1 218699528 7153680 complement(1217664..1218161) 1 NC_011750.1 cytoplasmic iron storage protein; ferritin 1218161 ftn 7153680 ftn Escherichia coli IAI39 ferritin YP_002407157.1 1217664 R 585057 CDS YP_002407158.1 218699529 7151432 complement(1218333..1218656) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1218656 yecR 7151432 yecR Escherichia coli IAI39 hypothetical protein YP_002407158.1 1218333 R 585057 CDS YP_002407159.1 218699530 7153687 complement(1218863..1219009) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1219009 7153687 ECIAI39_1149 Escherichia coli IAI39 hypothetical protein YP_002407159.1 1218863 R 585057 CDS YP_002407160.1 218699531 7151860 1219120..1219371 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1219371 yecJ 7151860 yecJ Escherichia coli IAI39 hypothetical protein YP_002407160.1 1219120 D 585057 CDS YP_002407161.1 218699532 7153682 complement(1219450..1219953) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative ferritin-like protein 1219953 yecI 7153682 yecI Escherichia coli IAI39 putative ferritin-like protein YP_002407161.1 1219450 R 585057 CDS YP_002407162.1 218699533 7153681 1220750..1221739 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89255061, 90375534, 2445996, 326784, 326785, 6885805, 7031057, 9298646; Product type t : transporter; L-arabinose ABC transporter subunit periplasmic-binding protein 1221739 araF 7153681 araF Escherichia coli IAI39 L-arabinose ABC transporter subunit periplasmic-binding protein YP_002407162.1 1220750 D 585057 CDS YP_002407163.1 218699534 7150752 1221809..1223323 1 NC_011750.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein 1223323 araG 7150752 araG Escherichia coli IAI39 L-arabinose transporter ATP-binding protein YP_002407163.1 1221809 D 585057 CDS YP_002407164.1 218699535 7150753 1223335..1224324 1 NC_011750.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter permease 1224324 araH 7150753 araH Escherichia coli IAI39 L-arabinose transporter permease YP_002407164.1 1223335 D 585057 CDS YP_002407165.1 218699536 7150754 1224491..1225291 1 NC_011750.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase 1225291 otsB 7150754 otsB Escherichia coli IAI39 trehalose-6-phosphate phosphatase YP_002407165.1 1224491 D 585057 CDS YP_002407166.1 218699537 7152313 1225266..1226690 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92078100, 92121128, 93302496, 8045430; Product type e : enzyme; trehalose-6-phosphate synthase 1226690 otsA 7152313 otsA Escherichia coli IAI39 trehalose-6-phosphate synthase YP_002407166.1 1225266 D 585057 CDS YP_002407167.1 218699538 7152312 complement(1226697..1227125) 1 NC_011750.1 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspC 1227125 yecG 7152312 yecG Escherichia coli IAI39 universal stress protein UspC YP_002407167.1 1226697 R 585057 CDS YP_002407168.1 218699539 7153679 1227896..1228255 1 NC_011750.1 with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD 1228255 flhD 7153679 flhD Escherichia coli IAI39 transcriptional activator FlhD YP_002407168.1 1227896 D 585057 CDS YP_002407169.1 218699540 7151367 1228963..1229850 1 NC_011750.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA 1229850 motA 7151367 motA Escherichia coli IAI39 flagellar motor protein MotA YP_002407169.1 1228963 D 585057 CDS YP_002407170.1 218699541 7152111 1229847..1230773 1 NC_011750.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB 1230773 motB 7152111 motB Escherichia coli IAI39 flagellar motor protein MotB YP_002407170.1 1229847 D 585057 CDS YP_002407171.1 218699542 7152112 1230778..1232742 1 NC_011750.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA 1232742 cheA 7152112 cheA Escherichia coli IAI39 chemotaxis protein CheA YP_002407171.1 1230778 D 585057 CDS YP_002407172.1 218699543 7150934 1232763..1233266 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91126073, 91296802, 91317710, 2002011, 3510184; Product type r : regulator; purine-binding chemotaxis protein 1233266 cheW 7150934 cheW Escherichia coli IAI39 purine-binding chemotaxis protein YP_002407172.1 1232763 D 585057 CDS YP_002407173.1 218699544 7150887 1233411..1235072 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90094243, 92165727, 6305515, 9315712; Product type r : regulator; methyl-accepting chemotaxis protein II 1235072 tar 7150887 tar Escherichia coli IAI39 methyl-accepting chemotaxis protein II YP_002407173.1 1233411 D 585057 CDS YP_002407174.1 218699545 7152941 1235363..1236223 1 NC_011750.1 methylates the MCP; chemotaxis methyltransferase CheR 1236223 cheR 7152941 cheR Escherichia coli IAI39 chemotaxis methyltransferase CheR YP_002407174.1 1235363 D 585057 CDS YP_002407175.1 218699546 7150936 1236226..1237275 1 NC_011750.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase 1237275 cheB 7150936 cheB Escherichia coli IAI39 chemotaxis-specific methylesterase YP_002407175.1 1236226 D 585057 CDS YP_002407176.1 218699547 7150935 1237290..1237679 1 NC_011750.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY 1237679 cheY 7150935 cheY Escherichia coli IAI39 chemotaxis regulatory protein CheY YP_002407176.1 1237290 D 585057 CDS YP_002407177.1 218699548 7150938 1237690..1238334 1 NC_011750.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis regulator CheZ 1238334 cheZ 7150938 cheZ Escherichia coli IAI39 chemotaxis regulator CheZ YP_002407177.1 1237690 D 585057 CDS YP_002407178.1 218699549 7150939 1238543..1239691 1 NC_011750.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB 1239691 flhB 7150939 flhB Escherichia coli IAI39 flagellar biosynthesis protein FlhB YP_002407178.1 1238543 D 585057 CDS YP_002407179.1 218699550 7151365 1239684..1241762 1 NC_011750.1 membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA 1241762 flhA 7151365 flhA Escherichia coli IAI39 flagellar biosynthesis protein FlhA YP_002407179.1 1239684 D 585057 CDS YP_002407180.1 218699551 7151364 1241762..1242154 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8002587, 1482109, 89181349; hypothetical protein 1242154 flhE 7151364 flhE Escherichia coli IAI39 hypothetical protein YP_002407180.1 1241762 D 585057 CDS YP_002407181.1 218699552 7151369 complement(1242207..1243940) 1 NC_011750.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1243940 argS 7151369 argS Escherichia coli IAI39 arginyl-tRNA synthetase YP_002407181.1 1242207 R 585057 CDS YP_002407182.1 218699553 7150772 1244156..1244722 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12660999; Product type pe : putative enzyme; hypothetical protein 1244722 yecM 7150772 yecM Escherichia coli IAI39 hypothetical protein YP_002407182.1 1244156 D 585057 CDS YP_002407183.1 218699554 7153683 1244736..1245482 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95362641, 7635807; Product type t : transporter; copper homeostasis protein CutC 1245482 cutC 7153683 cutC Escherichia coli IAI39 copper homeostasis protein CutC YP_002407183.1 1244736 D 585057 CDS YP_002407184.1 218699555 7151035 1245869..1246969 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461225, 8919859; Product type c : carrier; TMAO reductase III (TorYZ), cytochrome c-type subunit 1246969 torY 7151035 torY Escherichia coli IAI39 TMAO reductase III (TorYZ), cytochrome c-type subunit YP_002407184.1 1245869 D 585057 CDS YP_002407185.1 218699556 7153010 1246994..1249423 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97077292, 11004177; Product type e : enzyme; trimethylamine N-oxide reductase system III, catalytic subunit 1249423 torZ 7153010 torZ Escherichia coli IAI39 trimethylamine N-oxide reductase system III, catalytic subunit YP_002407185.1 1246994 D 585057 CDS YP_002407186.1 218699557 7153011 complement(1249458..1250429) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1250429 yecP 7153011 yecP Escherichia coli IAI39 hypothetical protein YP_002407186.1 1249458 R 585057 CDS YP_002407187.1 218699558 7153686 complement(1250426..1251169) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11746687; Product type e : enzyme; AdoMet-dependent methyltransferase 1251169 yecO 7153686 yecO Escherichia coli IAI39 AdoMet-dependent methyltransferase YP_002407187.1 1250426 R 585057 CDS YP_002407188.1 218699559 7153685 complement(1251210..1251605) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1251605 yecN 7153685 yecN Escherichia coli IAI39 hypothetical protein YP_002407188.1 1251210 R 585057 CDS YP_002407189.1 218699560 7153684 complement(1251658..1252476) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2129559, 7984428; hypothetical protein 1252476 yecE 7153684 yecE Escherichia coli IAI39 hypothetical protein YP_002407189.1 1251658 R 585057 CDS YP_002407190.1 218699561 7153677 complement(1252473..1253039) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 1253039 yecD 7153677 yecD Escherichia coli IAI39 hypothetical protein YP_002407190.1 1252473 R 585057 CDS YP_002407191.1 218699562 7153676 1253349..1255121 1 NC_011750.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1255121 aspS 7153676 aspS Escherichia coli IAI39 aspartyl-tRNA synthetase YP_002407191.1 1253349 D 585057 CDS YP_002407192.1 218699563 7150808 1255123..1255566 1 NC_011750.1 converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 1255566 ntpA 7150808 ntpA Escherichia coli IAI39 dATP pyrophosphohydrolase YP_002407192.1 1255123 D 585057 CDS YP_002407193.1 218699564 7152262 1255595..1256335 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1256335 yebC 7152262 yebC Escherichia coli IAI39 hypothetical protein YP_002407193.1 1255595 D 585057 CDS YP_002407194.1 218699565 7153658 1256370..1256891 1 NC_011750.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 1256891 ruvC 7153658 ruvC Escherichia coli IAI39 Holliday junction resolvase YP_002407194.1 1256370 D 585057 CDS YP_002407195.1 218699566 7152775 complement(1256893..1257495) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1257495 yebB 7152775 yebB Escherichia coli IAI39 hypothetical protein YP_002407195.1 1256893 R 585057 CDS YP_002407196.1 218699567 7153657 1257770..1258381 1 NC_011750.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 1258381 ruvA 7153657 ruvA Escherichia coli IAI39 Holliday junction DNA helicase RuvA YP_002407196.1 1257770 D 585057 CDS YP_002407197.1 218699568 7152773 1258390..1259400 1 NC_011750.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1259400 ruvB 7152773 ruvB Escherichia coli IAI39 Holliday junction DNA helicase RuvB YP_002407197.1 1258390 D 585057 CDS YP_002407198.1 218699569 7152774 complement(1259548..1260333) 1 NC_011750.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane component 1260333 znuB 7152774 znuB Escherichia coli IAI39 high-affinity zinc transporter membrane component YP_002407198.1 1259548 R 585057 CDS YP_002407199.1 218699570 7154593 complement(1260330..1261085) 1 NC_011750.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase 1261085 znuC 7154593 znuC Escherichia coli IAI39 high-affinity zinc transporter ATPase YP_002407199.1 1260330 R 585057 CDS YP_002407200.1 218699571 7154594 1261164..1262096 1 NC_011750.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic component 1262096 znuA 7154594 znuA Escherichia coli IAI39 high-affinity zinc transporter periplasmic component YP_002407200.1 1261164 D 585057 CDS YP_002407201.1 218699572 7154592 1262112..1263434 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1732206; Product type pe : putative enzyme; hypothetical protein 1263434 yebA 7154592 yebA Escherichia coli IAI39 hypothetical protein YP_002407201.1 1262112 D 585057 CDS YP_002407202.1 218699573 7153656 1263553..1264524 1 NC_011750.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 1264524 lpxM 7153656 lpxM Escherichia coli IAI39 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_002407202.1 1263553 D 585057 CDS YP_002407203.1 218699574 7151972 complement(1264656..1266098) 1 NC_011750.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1266098 pykA 7151972 pykA Escherichia coli IAI39 pyruvate kinase YP_002407203.1 1264656 R 585057 CDS YP_002407204.1 218699575 7152546 complement(1266226..1267095) 1 NC_011750.1 Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR 1267095 yebK 7152546 yebK Escherichia coli IAI39 DNA-binding transcriptional regulator HexR YP_002407204.1 1266226 R 585057 CDS YP_002407205.1 218699576 7153662 1267264..1267416 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1267416 7153662 ECIAI39_1197 Escherichia coli IAI39 hypothetical protein YP_002407205.1 1267264 D 585057 CDS YP_002407206.1 218699577 7149716 1267432..1268907 1 NC_011750.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1268907 zwf 7149716 zwf Escherichia coli IAI39 glucose-6-phosphate 1-dehydrogenase YP_002407206.1 1267432 D 585057 CDS YP_002407207.1 218699578 7154600 1269142..1270953 1 NC_011750.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 1270953 edd 7154600 edd Escherichia coli IAI39 phosphogluconate dehydratase YP_002407207.1 1269142 D 585057 CDS YP_002407208.1 218699579 7151203 1270990..1271631 1 NC_011750.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 1271631 eda 7151203 eda Escherichia coli IAI39 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_002407208.1 1270990 D 585057 CDS YP_002407209.1 218699580 7151202 complement(1271687..1272865) 1 NC_011750.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 1272865 purT 7151202 purT Escherichia coli IAI39 phosphoribosylglycinamide formyltransferase 2 YP_002407209.1 1271687 R 585057 CDS YP_002407210.1 218699581 7152535 1272999..1273289 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9368369, 99403401; Product type cp : cell process; DNA damage-inducible protein YebG 1273289 yebG 7152535 yebG Escherichia coli IAI39 DNA damage-inducible protein YebG YP_002407210.1 1272999 D 585057 CDS YP_002407211.1 218699582 7153661 1273344..1273712 1 NC_011750.1 secreted protein; unknown function; hypothetical protein 1273712 yebF 7153661 yebF Escherichia coli IAI39 hypothetical protein YP_002407211.1 1273344 D 585057 CDS YP_002407212.1 218699583 7153660 1274038..1274697 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1274697 yebE 7153660 yebE Escherichia coli IAI39 hypothetical protein YP_002407212.1 1274038 D 585057 CDS YP_002407213.1 218699584 7153659 1274904..1276964 1 NC_011750.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 1276964 ptrB 7153659 ptrB Escherichia coli IAI39 protease 2 YP_002407213.1 1274904 D 585057 CDS YP_002407214.1 218699585 7152516 complement(1276961..1277623) 1 NC_011750.1 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 1277623 exoX 7152516 exoX Escherichia coli IAI39 exodeoxyribonuclease X YP_002407214.1 1276961 R 585057 CDS YP_002407215.1 218699586 7151260 complement(1277647..1278303) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1278303 yobB 7151260 yobB Escherichia coli IAI39 hypothetical protein YP_002407215.1 1277647 R 585057 CDS YP_002407216.1 218699587 7154446 complement(1278405..1278635) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15090519, 92147649, 92156151, 94131961, 1575709, 8341603, 8505306; Product type e : enzyme; DNA polymerase III subunit theta 1278635 holE 7154446 holE Escherichia coli IAI39 DNA polymerase III subunit theta YP_002407216.1 1278405 R 585057 CDS YP_002407217.1 218699588 7151671 1278774..1279148 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1279148 yobA 7151671 yobA Escherichia coli IAI39 hypothetical protein YP_002407217.1 1278774 D 585057 CDS YP_002407218.1 218699589 7154445 1279152..1280024 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1280024 yebZ 7154445 yebZ Escherichia coli IAI39 hypothetical protein YP_002407218.1 1279152 D 585057 CDS YP_002407219.1 218699590 7153673 1280037..1280378 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1280378 yebY 7153673 yebY Escherichia coli IAI39 hypothetical protein YP_002407219.1 1280037 D 585057 CDS YP_002407220.1 218699591 7152781 1280772..1281428 1 NC_011750.1 Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins; serine/threonine protein phosphatase 1 1281428 pphA 7152781 pphA Escherichia coli IAI39 serine/threonine protein phosphatase 1 YP_002407220.1 1280772 D 585057 CDS YP_002407221.1 218699592 7152458 complement(1281429..1281704) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1281704 yebW 7152458 yebW Escherichia coli IAI39 hypothetical protein YP_002407221.1 1281429 R 585057 CDS YP_002407222.1 218699593 7153671 complement(1281725..1281961) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1281961 yebV 7153671 yebV Escherichia coli IAI39 hypothetical protein YP_002407222.1 1281725 R 585057 CDS YP_002407223.1 218699594 7153670 complement(1282079..1283518) 1 NC_011750.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF 1283518 yebU 7153670 yebU Escherichia coli IAI39 rRNA (cytosine-C(5)-)-methyltransferase RsmF YP_002407223.1 1282079 R 585057 CDS YP_002407224.1 218699595 7153669 complement(1283598..1286231) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1286231 yebT 7153669 yebT Escherichia coli IAI39 hypothetical protein YP_002407224.1 1283598 R 585057 CDS YP_002407225.1 218699596 7153668 complement(1286200..1287483) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1287483 yebS 7153668 yebS Escherichia coli IAI39 hypothetical protein YP_002407225.1 1286200 R 585057 CDS YP_002407226.1 218699597 7153667 1287559..1288110 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1288110 yebR 7153667 yebR Escherichia coli IAI39 hypothetical protein YP_002407226.1 1287559 D 585057 CDS YP_002407227.1 218699598 7153666 1288207..1288905 1 NC_011750.1 affects solute and DNA transport through an unknown mechanism; putative solute/DNA competence effector 1288905 proQ 7153666 proQ Escherichia coli IAI39 putative solute/DNA competence effector YP_002407227.1 1288207 D 585057 CDS YP_002407228.1 218699599 7152487 1288925..1290973 1 NC_011750.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 1290973 prc 7152487 prc Escherichia coli IAI39 carboxy-terminal protease YP_002407228.1 1288925 D 585057 CDS YP_002407229.1 218699600 7152471 1291165..1292046 1 NC_011750.1 putative metalloprotease; heat shock protein HtpX 1292046 htpX 7152471 htpX Escherichia coli IAI39 heat shock protein HtpX YP_002407229.1 1291165 D 585057 CDS YP_002407230.1 218699601 7151687 complement(1292092..1293465) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1293465 yebQ 7151687 yebQ Escherichia coli IAI39 putative MFS superfamily transporter YP_002407230.1 1292092 R 585057 CDS YP_002407231.1 218699602 7153665 1293642..1294433 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659677, 4359651; Product type r : regulator; DNA-binding transcriptional repressor KdgR 1294433 kdgR 7153665 kdgR Escherichia coli IAI39 DNA-binding transcriptional repressor KdgR YP_002407231.1 1293642 D 585057 CDS YP_002407232.1 218699603 7151878 complement(1294577..1294816) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1294816 yobH 7151878 yobH Escherichia coli IAI39 hypothetical protein YP_002407232.1 1294577 R 585057 CDS YP_002407233.1 218699604 7154449 1295193..1295480 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1295480 yebO 7154449 yebO Escherichia coli IAI39 hypothetical protein YP_002407233.1 1295193 D 585057 CDS YP_002407234.1 218699605 7153664 complement(1295982..1296188) 1 NC_011750.1 hypothetical protein 1296188 7153664 ECIAI39_1226 Escherichia coli IAI39 hypothetical protein YP_002407234.1 1295982 R 585057 CDS YP_002407235.1 218699606 7149717 1296150..1296293 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1296293 yobF 7149717 yobF Escherichia coli IAI39 hypothetical protein YP_002407235.1 1296150 D 585057 CDS YP_002407236.1 218699607 7154448 complement(1296264..1296848) 1 NC_011750.1 hypothetical protein 1296848 7154448 ECIAI39_1228 Escherichia coli IAI39 hypothetical protein YP_002407236.1 1296264 R 585057 CDS YP_002407237.1 218699608 7149718 1296306..1296515 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20345064, 21101802, 94293754, 12071744, 7984109, 8022261, 9298646, 9868784, 9921691; Product type f : factor; cold shock-like protein CspC 1296515 cspC 7149718 cspC Escherichia coli IAI39 cold shock-like protein CspC YP_002407237.1 1296306 D 585057 CDS YP_002407238.1 218699609 7151014 1296681..1297490 1 NC_011750.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase A 1297490 rrmA 7151014 rrmA Escherichia coli IAI39 23S rRNA methyltransferase A YP_002407238.1 1296681 D 585057 CDS YP_002407239.1 218699610 7152735 complement(1297487..1298053) 1 NC_011750.1 membrane protein YebN; hypothetical protein 1298053 yebN 7152735 yebN Escherichia coli IAI39 hypothetical protein YP_002407239.1 1297487 R 585057 CDS YP_002407240.1 218699611 7150527 complement(1298482..1298940) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1298940 yobD 7150527 yobD Escherichia coli IAI39 hypothetical protein YP_002407240.1 1298482 R 585057 CDS YP_002407241.1 218699612 7154447 complement(1298995..1299855) 1 NC_011750.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 1299855 manZ 7154447 manZ Escherichia coli IAI39 PTS system mannose-specific transporter subunit IID YP_002407241.1 1298995 R 585057 CDS YP_002407242.1 218699613 7152012 complement(1299859..1300659) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10473571, 87165962, 90036983, 94086520, 97128775, 7811395, 8774730; Product type t : transporter; PTS system mannose-specific protein subunit IIC 1300659 manY 7152012 manY Escherichia coli IAI39 PTS system mannose-specific protein subunit IIC YP_002407242.1 1299859 R 585057 CDS YP_002407243.1 218699614 7152011 complement(1300722..1301693) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87165962, 90036983, 8131846, 8676384, 9074635, 9298646; Product type t : transporter; PTS system manniose-specific transporter subunit IIAB 1301693 manX 7152011 manX Escherichia coli IAI39 PTS system manniose-specific transporter subunit IIAB YP_002407243.1 1300722 R 585057 CDS YP_002407244.1 218699615 7152010 1302156..1303712 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative membrane protein fused with conserved domain 1303712 yoaE 7152010 yoaE Escherichia coli IAI39 putative membrane protein fused with conserved domain YP_002407244.1 1302156 D 585057 CDS YP_002407245.1 218699616 7154440 complement(1303716..1305314) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16513732; Product type pe : putative enzyme; putative cyclic di-GMP phosphodiesterase 1305314 adrB 7154440 adrB Escherichia coli IAI39 putative cyclic di-GMP phosphodiesterase YP_002407245.1 1303716 R 585057 CDS YP_002407246.1 218699617 7150693 complement(1305445..1306809) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15155761, 89359152, 91056090, 93170282; Product type e : enzyme; L-serine deaminase I 1306809 sdaA 7150693 sdaA Escherichia coli IAI39 L-serine deaminase I YP_002407246.1 1305445 R 585057 CDS YP_002407247.1 218699618 7152810 complement(1306993..1307571) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pe : putative enzyme; hypothetical protein 1307571 yeaB 7152810 yeaB Escherichia coli IAI39 hypothetical protein YP_002407247.1 1306993 R 585057 CDS YP_002407248.1 218699619 7153632 complement(1307575..1308936) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88025006, 91067712, 91302313, 96011382, 6330050, 7896119; Product type e : enzyme; aminodeoxychorismate synthase subunit I 1308936 pabB 7153632 pabB Escherichia coli IAI39 aminodeoxychorismate synthase subunit I YP_002407248.1 1307575 R 585057 CDS YP_002407249.1 218699620 7152320 1309010..1309189 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1309189 yoaH 7152320 yoaH Escherichia coli IAI39 hypothetical protein YP_002407249.1 1309010 D 585057 CDS YP_002407250.1 218699621 7154443 complement(1309309..1309668) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1309668 yoaC 7154443 yoaC Escherichia coli IAI39 hypothetical protein YP_002407250.1 1309309 R 585057 CDS YP_002407251.1 218699622 7154439 1309859..1309954 1 NC_011750.1 hypothetical protein 1309954 7154439 ECIAI39_1243 Escherichia coli IAI39 hypothetical protein YP_002407251.1 1309859 D 585057 CDS YP_002407252.1 218699623 7149719 complement(1310030..1310374) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1310374 yoaB 7149719 yoaB Escherichia coli IAI39 hypothetical protein YP_002407252.1 1310030 R 585057 CDS YP_002407253.1 218699624 7154438 1310506..1312416 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-dependent helicase 1312416 yoaA 7154438 yoaA Escherichia coli IAI39 putative ATP-dependent helicase YP_002407253.1 1310506 D 585057 CDS YP_002407254.1 218699625 7154437 1312474..1313169 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 1313169 yeaZ 7154437 yeaZ Escherichia coli IAI39 putative peptidase YP_002407254.1 1312474 D 585057 CDS YP_002407255.1 218699626 7153655 1313208..1313789 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16079137; Product type lp : lipoprotein; putative outer membrane-associated lipoprotein 1313789 yeaY 7153655 yeaY Escherichia coli IAI39 putative outer membrane-associated lipoprotein YP_002407255.1 1313208 D 585057 CDS YP_002407256.1 218699627 7153654 1313994..1315679 1 NC_011750.1 Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1315679 fadD 7153654 fadD Escherichia coli IAI39 long-chain-fatty-acid--CoA ligase YP_002407256.1 1313994 D 585057 CDS YP_002407257.1 218699628 7151274 1315749..1316876 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88289400, 89053950, 93015723, 8107670; Product type e : enzyme; ribonuclease D 1316876 rnd 7151274 rnd Escherichia coli IAI39 ribonuclease D YP_002407257.1 1315749 D 585057 CDS YP_002407258.1 218699629 7152655 complement(1316923..1317888) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dioxygenase subunit 1317888 yeaX 7152655 yeaX Escherichia coli IAI39 putative dioxygenase subunit YP_002407258.1 1316923 R 585057 CDS YP_002407259.1 218699630 7153653 complement(1317944..1319068) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 2Fe-2S cluster-containing dioxygenase subunit 1319068 yeaW 7153653 yeaW Escherichia coli IAI39 putative 2Fe-2S cluster-containing dioxygenase subunit YP_002407259.1 1317944 R 585057 CDS YP_002407260.1 218699631 7153652 complement(1319100..1320545) 1 NC_011750.1 member of the betaine, carnitine, choline transporter (BCCT) family; unknown function; putative transporter 1320545 yeaV 7153652 yeaV Escherichia coli IAI39 putative transporter YP_002407260.1 1319100 R 585057 CDS YP_002407261.1 218699632 7153651 complement(1320961..1322046) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative tartrate dehydrogenase 1322046 yeaU 7153651 yeaU Escherichia coli IAI39 putative tartrate dehydrogenase YP_002407261.1 1320961 R 585057 CDS YP_002407262.1 218699633 7153650 1322149..1323072 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1323072 yeaT 7153650 yeaT Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002407262.1 1322149 D 585057 CDS YP_002407263.1 218699634 7153649 1323199..1323837 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; leucine export protein LeuE 1323837 yeaS 7153649 yeaS Escherichia coli IAI39 leucine export protein LeuE YP_002407263.1 1323199 D 585057 CDS YP_002407264.1 218699635 7153648 1324010..1324369 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1324369 yeaR 7153648 yeaR Escherichia coli IAI39 hypothetical protein YP_002407264.1 1324010 D 585057 CDS YP_002407265.1 218699636 7153647 1324373..1324555 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1324555 yoaG 7153647 yoaG Escherichia coli IAI39 hypothetical protein YP_002407265.1 1324373 D 585057 CDS YP_002407266.1 218699637 7154442 1324703..1324951 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1324951 yeaQ 7154442 yeaQ Escherichia coli IAI39 hypothetical protein YP_002407266.1 1324703 D 585057 CDS YP_002407267.1 218699638 7153646 complement(1325218..1326243) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase 1326243 yeaP 7153646 yeaP Escherichia coli IAI39 putative diguanylate cyclase YP_002407267.1 1325218 R 585057 CDS YP_002407268.1 218699639 7153645 1326426..1326680 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1326680 yoaF 7153645 yoaF Escherichia coli IAI39 hypothetical protein YP_002407268.1 1326426 D 585057 CDS YP_002407269.1 218699640 7154441 complement(1326702..1327049) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1327049 yeaO 7154441 yeaO Escherichia coli IAI39 hypothetical protein YP_002407269.1 1326702 R 585057 CDS YP_002407270.1 218699641 7153644 complement(1327104..1328285) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1328285 yeaN 7153644 yeaN Escherichia coli IAI39 putative MFS superfamily transporter YP_002407270.1 1327104 R 585057 CDS YP_002407271.1 218699642 7153643 1328382..1329203 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1329203 yeaM 7153643 yeaM Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002407271.1 1328382 D 585057 CDS YP_002407272.1 218699643 7153642 complement(1329160..1329606) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1329606 yeaL 7153642 yeaL Escherichia coli IAI39 hypothetical protein YP_002407272.1 1329160 R 585057 CDS YP_002407273.1 218699644 7153641 1329776..1329880 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1329880 yoaI 7153641 yoaI Escherichia coli IAI39 hypothetical protein YP_002407273.1 1329776 D 585057 CDS YP_002407274.1 218699645 7154444 complement(1329881..1330384) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1330384 yeaK 7154444 yeaK Escherichia coli IAI39 hypothetical protein YP_002407274.1 1329881 R 585057 CDS YP_002407275.1 218699646 7153640 complement(1330427..1331917) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase 1331917 yeaJ 7153640 yeaJ Escherichia coli IAI39 putative diguanylate cyclase YP_002407275.1 1330427 R 585057 CDS YP_002407276.1 218699647 7153639 complement(1332098..1333573) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase 1333573 yeaI 7153639 yeaI Escherichia coli IAI39 putative diguanylate cyclase YP_002407276.1 1332098 R 585057 CDS YP_002407277.1 218699648 7153638 complement(1333720..1335003) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1335003 yeaH 7153638 yeaH Escherichia coli IAI39 hypothetical protein YP_002407277.1 1333720 R 585057 CDS YP_002407278.1 218699649 7153637 complement(1335116..1337050) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1337050 yeaG 7153637 yeaG Escherichia coli IAI39 hypothetical protein YP_002407278.1 1335116 R 585057 CDS YP_002407279.1 218699650 7153636 1337486..1338232 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10037771, 20267815; Product type f : factor; scaffolding protein for murein synthesizing machinery 1338232 mipA 7153636 mipA Escherichia coli IAI39 scaffolding protein for murein synthesizing machinery YP_002407279.1 1337486 D 585057 CDS YP_002407280.1 218699651 7152087 1338322..1339176 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1339176 yeaE 7152087 yeaE Escherichia coli IAI39 putative oxidoreductase YP_002407280.1 1338322 D 585057 CDS YP_002407281.1 218699652 7153635 complement(1339227..1340111) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1340111 yeaD 7153635 yeaD Escherichia coli IAI39 hypothetical protein YP_002407281.1 1339227 R 585057 CDS YP_002407282.1 218699653 7153634 complement(1340195..1341190) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 775311, 94131963, 98361923, 1862091, 2124629, 2990926, 7896119, 8636984, 9298646; Product type e : enzyme; glyceraldehyde-3-phosphate dehydrogenase A 1341190 gapA 7153634 gapA Escherichia coli IAI39 glyceraldehyde-3-phosphate dehydrogenase A YP_002407282.1 1340195 R 585057 CDS YP_002407283.1 218699654 7151480 1341532..1341945 1 NC_011750.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 1341945 msrB 7151480 msrB Escherichia coli IAI39 methionine sulfoxide reductase B YP_002407283.1 1341532 D 585057 CDS YP_002407284.1 218699655 7152135 1341987..1342259 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1342259 yeaC 7152135 yeaC Escherichia coli IAI39 hypothetical protein YP_002407284.1 1341987 D 585057 CDS YP_002407285.1 218699656 7153633 1342629..1343705 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1343705 ydjL 7153633 ydjL Escherichia coli IAI39 putative oxidoreductase YP_002407285.1 1342629 D 585057 CDS YP_002407286.1 218699657 7153623 1343732..1345111 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1345111 ydjK 7153623 ydjK Escherichia coli IAI39 putative MFS superfamily transporter YP_002407286.1 1343732 D 585057 CDS YP_002407287.1 218699658 7153622 1345128..1346171 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12897001; Product type pe : putative enzyme; putative iditol dehydrogenase 1346171 ydjJ 7153622 ydjJ Escherichia coli IAI39 putative iditol dehydrogenase YP_002407287.1 1345128 D 585057 CDS YP_002407288.1 218699659 7153621 1346192..1347028 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldolase 1347028 ydjI 7153621 ydjI Escherichia coli IAI39 putative aldolase YP_002407288.1 1346192 D 585057 CDS YP_002407289.1 218699660 7153620 1347033..1347980 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar kinase 1347980 ydjH 7153620 ydjH Escherichia coli IAI39 putative sugar kinase YP_002407289.1 1347033 D 585057 CDS YP_002407290.1 218699661 7153619 1347990..1348970 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1348970 ydjG 7153619 ydjG Escherichia coli IAI39 putative oxidoreductase YP_002407290.1 1347990 D 585057 CDS YP_002407291.1 218699662 7153618 1349107..1349865 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1349865 ydjF 7153618 ydjF Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002407291.1 1349107 D 585057 CDS YP_002407292.1 218699663 7153617 complement(1350107..1350610) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS1 1350610 insB 7153617 insB Escherichia coli IAI39 transposase ORF B, IS1 YP_002407292.1 1350107 R 585057 CDS YP_002407293.1 218699664 7151795 complement(1350529..1350804) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 1350804 insA 7151795 insA Escherichia coli IAI39 IS1 repressor protein InsA YP_002407293.1 1350529 R 585057 CDS YP_002407294.1 218699665 7151784 1350866..1352116 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1352116 ydjE 7151784 ydjE Escherichia coli IAI39 putative MFS superfamily transporter YP_002407294.1 1350866 D 585057 CDS YP_002407295.1 218699666 7153616 complement(1352209..1352850) 1 NC_011750.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase 1352850 pncA 7153616 pncA Escherichia coli IAI39 nicotinamidase/pyrazinamidase YP_002407295.1 1352209 R 585057 CDS YP_002407296.1 218699667 7152433 complement(1352861..1353877) 1 NC_011750.1 converts asparagine to aspartate and ammonia; cytoplasmic asparaginase I 1353877 ansA 7152433 ansA Escherichia coli IAI39 cytoplasmic asparaginase I YP_002407296.1 1352861 R 585057 CDS YP_002407297.1 218699668 7150737 complement(1354044..1355900) 1 NC_011750.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 1355900 sppA 7150737 sppA Escherichia coli IAI39 protease 4 YP_002407297.1 1354044 R 585057 CDS YP_002407298.1 218699669 7152888 1356061..1356612 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 1356612 ydjA 7152888 ydjA Escherichia coli IAI39 hypothetical protein YP_002407298.1 1356061 D 585057 CDS YP_002407299.1 218699670 7153615 1356638..1356787 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1356787 7153615 ECIAI39_1291 Escherichia coli IAI39 hypothetical protein YP_002407299.1 1356638 D 585057 CDS YP_002407300.1 218699671 7149720 1356729..1357772 1 NC_011750.1 catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 1357772 selD 7149720 selD Escherichia coli IAI39 selenophosphate synthetase YP_002407300.1 1356729 D 585057 CDS YP_002407301.1 218699672 7152828 1357720..1359732 1 NC_011750.1 decatenates replicating daughter chromosomes; DNA topoisomerase III 1359732 topB 7152828 topB Escherichia coli IAI39 DNA topoisomerase III YP_002407301.1 1357720 D 585057 CDS YP_002407302.1 218699673 7153003 complement(1359809..1361152) 1 NC_011750.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1361152 gdhA 7153003 gdhA Escherichia coli IAI39 glutamate dehydrogenase YP_002407302.1 1359809 R 585057 CDS YP_002407303.1 218699674 7151501 complement(1361626..1362033) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101911; Product type e : enzyme; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 1362033 nudG 7151501 nudG Escherichia coli IAI39 pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase YP_002407303.1 1361626 R 585057 CDS YP_002407304.1 218699675 7152267 1362120..1362740 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type m : membrane component; putative phosphatidyl transferase, inner membrane protein 1362740 ynjF 7152267 ynjF Escherichia coli IAI39 putative phosphatidyl transferase, inner membrane protein YP_002407304.1 1362120 D 585057 CDS YP_002407305.1 218699676 7154436 complement(1362749..1364056) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported thiosulfate sulfur transferase / thiosulfate binding protein 1364056 ynjE 7154436 ynjE Escherichia coli IAI39 putative exported thiosulfate sulfur transferase / thiosulfate binding protein YP_002407305.1 1362749 R 585057 CDS YP_002407306.1 218699677 7154435 complement(1364123..1364776) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sulfate/thiosulfate ABC transporter ATP-binding protein 1364776 ynjD 7154435 ynjD Escherichia coli IAI39 putative sulfate/thiosulfate ABC transporter ATP-binding protein YP_002407306.1 1364123 R 585057 CDS YP_002407307.1 218699678 7154434 complement(1364776..1366266) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; ABC transporter membrane protein 1366266 ynjC 7154434 ynjC Escherichia coli IAI39 ABC transporter membrane protein YP_002407307.1 1364776 R 585057 CDS YP_002407308.1 218699679 7154433 complement(1366284..1367450) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative ABC transporter solute-binding protein 1367450 ynjB 7154433 ynjB Escherichia coli IAI39 putative ABC transporter solute-binding protein YP_002407308.1 1366284 R 585057 CDS YP_002407309.1 218699680 7154432 complement(1367460..1368008) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1368008 ynjA 7154432 ynjA Escherichia coli IAI39 hypothetical protein YP_002407309.1 1367460 R 585057 CDS YP_002407310.1 218699681 7154431 complement(1368008..1368715) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1368715 ydjZ 7154431 ydjZ Escherichia coli IAI39 hypothetical protein YP_002407310.1 1368008 R 585057 CDS YP_002407311.1 218699682 7153631 complement(1368730..1369407) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1369407 ydjY 7153631 ydjY Escherichia coli IAI39 hypothetical protein YP_002407311.1 1368730 R 585057 CDS YP_002407312.1 218699683 7153630 complement(1369412..1370122) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1370122 ydjX 7153630 ydjX Escherichia coli IAI39 hypothetical protein YP_002407312.1 1369412 R 585057 CDS YP_002407313.1 218699684 7153629 complement(1370289..1371095) 1 NC_011750.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 1371095 xthA 7153629 xthA Escherichia coli IAI39 exonuclease III YP_002407313.1 1370289 R 585057 CDS YP_002407314.1 218699685 7153184 1371541..1372761 1 NC_011750.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate; bifunctional succinylornithine transaminase/acetylornithine transaminase 1372761 astC 7153184 astC Escherichia coli IAI39 bifunctional succinylornithine transaminase/acetylornithine transaminase YP_002407314.1 1371541 D 585057 CDS YP_002407315.1 218699686 7150812 1372758..1373792 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14675764, 98361920; Product type e : enzyme; arginine succinyltransferase 1373792 astA 7150812 astA Escherichia coli IAI39 arginine succinyltransferase YP_002407315.1 1372758 D 585057 CDS YP_002407316.1 218699687 7150810 1373789..1375267 1 NC_011750.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase 1375267 astD 7150810 astD Escherichia coli IAI39 succinylglutamic semialdehyde dehydrogenase YP_002407316.1 1373789 D 585057 CDS YP_002407317.1 218699688 7150813 1375264..1376607 1 NC_011750.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation; succinylarginine dihydrolase 1376607 astB 7150813 astB Escherichia coli IAI39 succinylarginine dihydrolase YP_002407317.1 1375264 D 585057 CDS YP_002407318.1 218699689 7150811 1376600..1377568 1 NC_011750.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase 1377568 astE 7150811 astE Escherichia coli IAI39 succinylglutamate desuccinylase YP_002407318.1 1376600 D 585057 CDS YP_002407319.1 218699690 7150814 1377898..1378383 1 NC_011750.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; periplasmic protein 1378383 spy 7150814 spy Escherichia coli IAI39 periplasmic protein YP_002407319.1 1377898 D 585057 CDS YP_002407320.1 218699691 7152891 1378586..1379161 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21862596; hypothetical protein 1379161 ydjR 7152891 ydjR Escherichia coli IAI39 hypothetical protein YP_002407320.1 1378586 D 585057 CDS YP_002407321.1 218699692 7153628 complement(1379121..1380008) 1 NC_011750.1 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease 1380008 ydjQ 7153628 ydjQ Escherichia coli IAI39 nucleotide excision repair endonuclease YP_002407321.1 1379121 R 585057 CDS YP_002407322.1 218699693 7153627 complement(1380238..1381065) 1 NC_011750.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1381065 nadE 7153627 nadE Escherichia coli IAI39 NAD synthetase YP_002407322.1 1380238 R 585057 CDS YP_002407323.1 218699694 7152169 1381267..1381605 1 NC_011750.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE 1381605 osmE 7152169 osmE Escherichia coli IAI39 DNA-binding transcriptional activator OsmE YP_002407323.1 1381267 D 585057 CDS YP_002407324.1 218699695 7152310 1381904..1382224 1 NC_011750.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB 1382224 chbB 7152310 chbB Escherichia coli IAI39 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB YP_002407324.1 1381904 D 585057 CDS YP_002407325.1 218699696 7150929 1382309..1383667 1 NC_011750.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC 1383667 chbC 7150929 chbC Escherichia coli IAI39 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC YP_002407325.1 1382309 D 585057 CDS YP_002407326.1 218699697 7150930 1383718..1384068 1 NC_011750.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA 1384068 chbA 7150930 chbA Escherichia coli IAI39 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA YP_002407326.1 1383718 D 585057 CDS YP_002407327.1 218699698 7150928 1384076..1384918 1 NC_011750.1 represses the celABCDF-ydjC operon involved in carbon uptake; DNA-binding transcriptional regulator ChbR 1384918 chbR 7150928 chbR Escherichia coli IAI39 DNA-binding transcriptional regulator ChbR YP_002407327.1 1384076 D 585057 CDS YP_002407328.1 218699699 7150933 1385022..1386374 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20042356, 90185127, 9405618; Product type e : enzyme; cryptic phospho-beta-glucosidase, NAD(P)-binding 1386374 chbF 7150933 chbF Escherichia coli IAI39 cryptic phospho-beta-glucosidase, NAD(P)-binding YP_002407328.1 1385022 D 585057 CDS YP_002407329.1 218699700 7150931 1386387..1387136 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 20042356, 1987146, 2179047, 8121401, 9405618; hypothetical protein 1387136 chbG 7150931 chbG Escherichia coli IAI39 hypothetical protein YP_002407329.1 1386387 D 585057 CDS YP_002407330.1 218699701 7150932 complement(1387183..1389444) 1 NC_011750.1 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II 1389444 katE 7150932 katE Escherichia coli IAI39 hydroperoxidase II YP_002407330.1 1387183 R 585057 CDS YP_002407331.1 218699702 7151871 1389627..1389890 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9427399; Product type cp : cell process; cell division modulator 1389890 cedA 7151871 cedA Escherichia coli IAI39 cell division modulator YP_002407331.1 1389627 D 585057 CDS YP_002407332.1 218699703 7150923 1390167..1390982 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1390982 ydjO 7150923 ydjO Escherichia coli IAI39 hypothetical protein YP_002407332.1 1390167 D 585057 CDS YP_002407333.1 218699704 7153626 complement(1390986..1392377) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative cation-acid symporter 1392377 ydjN 7153626 ydjN Escherichia coli IAI39 putative cation-acid symporter YP_002407333.1 1390986 R 585057 CDS YP_002407334.1 218699705 7153625 complement(1392510..1393100) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10760155; Product type pm : putative membrane component; hypothetical protein 1393100 ydjM 7153625 ydjM Escherichia coli IAI39 hypothetical protein YP_002407334.1 1392510 R 585057 CDS YP_002407335.1 218699706 7153624 complement(1393263..1393931) 1 NC_011750.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase 1393931 yniC 7153624 yniC Escherichia coli IAI39 2-deoxyglucose-6-phosphatase YP_002407335.1 1393263 R 585057 CDS YP_002407336.1 218699707 7154430 1394078..1394614 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1394614 yniB 7154430 yniB Escherichia coli IAI39 hypothetical protein YP_002407336.1 1394078 D 585057 CDS YP_002407337.1 218699708 7154429 complement(1394655..1395515) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase/kinase 1395515 yniA 7154429 yniA Escherichia coli IAI39 putative phosphotransferase/kinase YP_002407337.1 1394655 R 585057 CDS YP_002407338.1 218699709 7154428 complement(1395621..1395911) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1395911 ydiZ 7154428 ydiZ Escherichia coli IAI39 hypothetical protein YP_002407338.1 1395621 R 585057 CDS YP_002407339.1 218699710 7153614 complement(1396012..1396941) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 78194149, 88292964, 6235149, 6310120; Product type e : enzyme; 6-phosphofructokinase 2 1396941 pfkB 7153614 pfkB Escherichia coli IAI39 6-phosphofructokinase 2 YP_002407339.1 1396012 R 585057 CDS YP_002407340.1 218699711 7152371 1397228..1397986 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1397986 ydiY 7152371 ydiY Escherichia coli IAI39 hypothetical protein YP_002407340.1 1397228 D 585057 CDS YP_002407341.1 218699712 7153613 complement(1398039..1398257) 1 NC_011750.1 hypothetical protein 1398257 7153613 ECIAI39_1333 Escherichia coli IAI39 hypothetical protein YP_002407341.1 1398039 R 585057 CDS YP_002407342.1 218699713 7149721 complement(1398313..1400211) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative ankyrin repeat regulatory protein 1400211 7149721 ECIAI39_1334 Escherichia coli IAI39 putative ankyrin repeat regulatory protein YP_002407342.1 1398313 R 585057 CDS YP_002407343.1 218699714 7149722 1400734..1402662 1 NC_011750.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 1402662 thrS 7149722 thrS Escherichia coli IAI39 threonyl-tRNA synthetase YP_002407343.1 1400734 D 585057 CDS YP_002407344.1 218699715 7151779 1403305..1403502 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93085722, 10094780, 3298224, 3542048, 6325158; Product type s : structure; 50S ribosomal protein L35 1403502 rpmI 7151779 rpmI Escherichia coli IAI39 50S ribosomal protein L35 YP_002407344.1 1403305 D 585057 CDS YP_002407345.1 218699716 7152702 1403556..1403912 1 NC_011750.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1403912 rplT 7152702 rplT Escherichia coli IAI39 50S ribosomal protein L20 YP_002407345.1 1403556 D 585057 CDS YP_002407347.1 218699718 7152390 1404218..1405201 1 NC_011750.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1405201 pheS 7152390 pheS Escherichia coli IAI39 phenylalanyl-tRNA synthetase subunit alpha YP_002407347.1 1404218 D 585057 CDS YP_002407348.1 218699719 7152392 1405216..1407603 1 NC_011750.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1407603 pheT 7152392 pheT Escherichia coli IAI39 phenylalanyl-tRNA synthetase subunit beta YP_002407348.1 1405216 D 585057 CDS YP_002407349.1 218699720 7152393 1407608..1407907 1 NC_011750.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 1407907 ihfA 7152393 ihfA Escherichia coli IAI39 integration host factor subunit alpha YP_002407349.1 1407608 D 585057 CDS YP_002407350.1 218699721 7151760 1408008..1408988 1 NC_011750.1 with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease 1408988 btuC 7151760 btuC Escherichia coli IAI39 vtamin B12-transporter permease YP_002407350.1 1408008 D 585057 CDS YP_002407351.1 218699722 7150879 1409051..1409602 1 NC_011750.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; putative glutathione peroxidase 1409602 btuE 7150879 btuE Escherichia coli IAI39 putative glutathione peroxidase YP_002407351.1 1409051 D 585057 CDS YP_002407352.1 218699723 7150881 1409602..1410351 1 NC_011750.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase 1410351 btuD 7150881 btuD Escherichia coli IAI39 vitamin B12-transporter ATPase YP_002407352.1 1409602 D 585057 CDS YP_002407353.1 218699724 7150880 1410429..1410893 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12620121; Product type lp : lipoprotein; putative peptidase lipoprotein 1410893 nlpC 7150880 nlpC Escherichia coli IAI39 putative peptidase lipoprotein YP_002407353.1 1410429 D 585057 CDS YP_002407354.1 218699725 7152235 1411140..1411853 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1411853 ydiV 7152235 ydiV Escherichia coli IAI39 hypothetical protein YP_002407354.1 1411140 D 585057 CDS YP_002407355.1 218699726 7153612 1411916..1413352 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1413352 ydiU 7153612 ydiU Escherichia coli IAI39 hypothetical protein YP_002407355.1 1411916 D 585057 CDS YP_002407356.1 218699727 7153611 complement(1413356..1413547) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15039350; hypothetical protein 1413547 ydiE 7153611 ydiE Escherichia coli IAI39 hypothetical protein YP_002407356.1 1413356 R 585057 CDS YP_002407357.1 218699728 7153595 complement(1413679..1414725) 1 NC_011750.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 1414725 aroH 7153595 aroH Escherichia coli IAI39 phospho-2-dehydro-3-deoxyheptonate aldolase YP_002407357.1 1413679 R 585057 CDS YP_002407358.1 218699729 7150782 complement(1414882..1415715) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1415715 ydiA 7150782 ydiA Escherichia coli IAI39 hypothetical protein YP_002407358.1 1414882 R 585057 CDS YP_002407359.1 218699730 7153592 1416047..1418425 1 NC_011750.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase 1418425 pps 7153592 pps Escherichia coli IAI39 phosphoenolpyruvate synthase YP_002407359.1 1416047 D 585057 CDS YP_002407360.1 218699731 7152466 1418908..1420314 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative dicarboxylate transporter 1420314 7152466 ECIAI39_1352 Escherichia coli IAI39 putative dicarboxylate transporter YP_002407360.1 1418908 D 585057 CDS YP_002407361.1 218699732 7149723 1420350..1421309 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 2-hydroxyacid dehydrogenase/reductase 1421309 7149723 ECIAI39_1353 Escherichia coli IAI39 putative 2-hydroxyacid dehydrogenase/reductase YP_002407361.1 1420350 D 585057 CDS YP_002407362.1 218699733 7149724 1421320..1421799 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1421799 7149724 ECIAI39_1354 Escherichia coli IAI39 hypothetical protein YP_002407362.1 1421320 D 585057 CDS YP_002407363.1 218699734 7149725 1421812..1422555 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10800688; Product type pe : putative enzyme; putative short-chain dehydrogenase/reductase 1422555 7149725 ECIAI39_1355 Escherichia coli IAI39 putative short-chain dehydrogenase/reductase YP_002407363.1 1421812 D 585057 CDS YP_002407364.1 218699735 7149726 complement(1422606..1424300) 1 NC_011750.1 acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids; short chain acyl-CoA synthetase 1424300 ydiD 7149726 ydiD Escherichia coli IAI39 short chain acyl-CoA synthetase YP_002407364.1 1422606 R 585057 CDS YP_002407365.1 218699736 7153594 complement(1424303..1424596) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S ferredoxin-type oxidoreductase subunit 1424596 ydiT 7153594 ydiT Escherichia coli IAI39 putative 4Fe-4S ferredoxin-type oxidoreductase subunit YP_002407365.1 1424303 R 585057 CDS YP_002407366.1 218699737 7153610 complement(1424593..1425882) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; hypothetical protein 1425882 ydiS 7153610 ydiS Escherichia coli IAI39 hypothetical protein YP_002407366.1 1424593 R 585057 CDS YP_002407367.1 218699738 7153609 complement(1425937..1426875) 1 NC_011750.1 May play a role in a redox process; electron transfer flavoprotein subunit YdiR 1426875 ydiR 7153609 ydiR Escherichia coli IAI39 electron transfer flavoprotein subunit YdiR YP_002407367.1 1425937 R 585057 CDS YP_002407368.1 218699739 7153608 complement(1426895..1427659) 1 NC_011750.1 YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; putative electron transfer flavoprotein YdiQ 1427659 ydiQ 7153608 ydiQ Escherichia coli IAI39 putative electron transfer flavoprotein YdiQ YP_002407368.1 1426895 R 585057 CDS YP_002407369.1 218699740 7153607 1427975..1428886 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1428886 ydiP 7153607 ydiP Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002407369.1 1427975 D 585057 CDS YP_002407370.1 218699741 7153605 complement(1430062..1431657) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16253988; Product type e : enzyme; short chain acyl-CoA transferase subunit alpha/beta 1431657 ydiF 7153605 ydiF Escherichia coli IAI39 short chain acyl-CoA transferase subunit alpha/beta YP_002407370.1 1430062 R 585057 CDS YP_002407371.1 218699742 7153596 complement(1431803..1432561) 1 NC_011750.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1432561 aroD 7153596 aroD Escherichia coli IAI39 3-dehydroquinate dehydratase YP_002407371.1 1431803 R 585057 CDS YP_002407372.1 218699743 7150778 complement(1432592..1433458) 1 NC_011750.1 YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase 1433458 ydiB 7150778 ydiB Escherichia coli IAI39 quinate/shikimate dehydrogenase YP_002407372.1 1432592 R 585057 CDS YP_002407373.1 218699744 7153593 complement(1433470..1434735) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 1434735 ydiN 7153593 ydiN Escherichia coli IAI39 putative transporter YP_002407373.1 1433470 R 585057 CDS YP_002407374.1 218699745 7153603 complement(1434962..1436176) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1436176 ydiM 7153603 ydiM Escherichia coli IAI39 putative MFS superfamily transporter YP_002407374.1 1434962 R 585057 CDS YP_002407375.1 218699746 7153602 complement(1436276..1436632) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1436632 ydiL 7153602 ydiL Escherichia coli IAI39 hypothetical protein YP_002407375.1 1436276 R 585057 CDS YP_002407376.1 218699747 7152712 complement(1437061..1438173) 1 NC_011750.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; putative inner membrane protein 1438173 ydiK 7152712 ydiK Escherichia coli IAI39 putative inner membrane protein YP_002407376.1 1437061 R 585057 CDS YP_002407377.1 218699748 7153600 1438560..1441616 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11102686; Product type pe : putative enzyme; putative FAD-linked oxidoreductase 1441616 ydiJ 7153600 ydiJ Escherichia coli IAI39 putative FAD-linked oxidoreductase YP_002407377.1 1438560 D 585057 CDS YP_002407378.1 218699749 7153599 1441613..1442023 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme; hypothetical protein 1442023 ydiI 7153599 ydiI Escherichia coli IAI39 hypothetical protein YP_002407378.1 1441613 D 585057 CDS YP_002407379.1 218699750 7153598 1442042..1442311 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1442311 ydiH 7153598 ydiH Escherichia coli IAI39 hypothetical protein YP_002407379.1 1442042 D 585057 CDS YP_002407380.1 218699751 7152779 1442860..1443228 1 NC_011750.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein 1443228 sufA 7152779 sufA Escherichia coli IAI39 iron-sulfur cluster assembly scaffold protein YP_002407380.1 1442860 D 585057 CDS YP_002407381.1 218699752 7152922 1443237..1444724 1 NC_011750.1 with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB 1444724 sufB 7152922 sufB Escherichia coli IAI39 cysteine desulfurase activator complex subunit SufB YP_002407381.1 1443237 D 585057 CDS YP_002407382.1 218699753 7152923 1444734..1445480 1 NC_011750.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase ATPase 1445480 sufC 7152923 sufC Escherichia coli IAI39 cysteine desulfurase ATPase YP_002407382.1 1444734 D 585057 CDS YP_002407383.1 218699754 7152924 1445455..1446726 1 NC_011750.1 with SufBC activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufD 1446726 sufD 7152924 sufD Escherichia coli IAI39 cysteine desulfurase activator complex subunit SufD YP_002407383.1 1445455 D 585057 CDS YP_002407384.1 218699755 7152925 1446723..1447943 1 NC_011750.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase 1447943 sufS 7152925 sufS Escherichia coli IAI39 bifunctional cysteine desulfurase/selenocysteine lyase YP_002407384.1 1446723 D 585057 CDS YP_002407385.1 218699756 7152928 1447956..1448372 1 NC_011750.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE 1448372 sufE 7152928 sufE Escherichia coli IAI39 cysteine desufuration protein SufE YP_002407385.1 1447956 D 585057 CDS YP_002407386.1 218699757 7152926 1448521..1449525 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1449525 ynhG 7152926 ynhG Escherichia coli IAI39 hypothetical protein YP_002407386.1 1448521 D 585057 CDS YP_002407387.1 218699758 7154427 complement(1449588..1449824) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 334727, 338599, 322142, 353292, 391404, 4261992, 4575979, 6765942; Product type lp : lipoprotein; murein lipoprotein 1449824 lpp 7154427 lpp Escherichia coli IAI39 murein lipoprotein YP_002407387.1 1449588 R 585057 CDS YP_002407388.1 218699759 7151962 complement(1450135..1451547) 1 NC_011750.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1451547 pykF 7151962 pykF Escherichia coli IAI39 pyruvate kinase YP_002407388.1 1450135 R 585057 CDS YP_002407389.1 218699760 7152547 1452104..1452313 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1452313 ydhZ 7152547 ydhZ Escherichia coli IAI39 hypothetical protein YP_002407389.1 1452104 D 585057 CDS YP_002407390.1 218699761 7153591 1452770..1453396 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; hypothetical protein 1453396 ydhY 7153591 ydhY Escherichia coli IAI39 hypothetical protein YP_002407390.1 1452770 D 585057 CDS YP_002407391.1 218699762 7153590 1453417..1455519 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1455519 ydhV 7153590 ydhV Escherichia coli IAI39 putative oxidoreductase YP_002407391.1 1453417 D 585057 CDS YP_002407392.1 218699763 7153588 1455523..1456170 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1456170 ydhW 7153588 ydhW Escherichia coli IAI39 hypothetical protein YP_002407392.1 1455523 D 585057 CDS YP_002407393.1 218699764 7153589 1456899..1457684 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative cytochrome b subunit of a reductase 1457684 ydhU 7153589 ydhU Escherichia coli IAI39 putative cytochrome b subunit of a reductase YP_002407393.1 1456899 D 585057 CDS YP_002407394.1 218699765 7153587 1457688..1458500 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1458500 ydhT 7153587 ydhT Escherichia coli IAI39 hypothetical protein YP_002407394.1 1457688 D 585057 CDS YP_002407395.1 218699766 7153586 complement(1458512..1460116) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1460116 ydhS 7153586 ydhS Escherichia coli IAI39 hypothetical protein YP_002407395.1 1458512 R 585057 CDS YP_002407396.1 218699767 7153585 complement(1460242..1460547) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1460547 ydhR 7153585 ydhR Escherichia coli IAI39 hypothetical protein YP_002407396.1 1460242 R 585057 CDS YP_002407397.1 218699768 7150619 1461121..1462377 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1462377 ydhQ 7150619 ydhQ Escherichia coli IAI39 hypothetical protein YP_002407397.1 1461121 D 585057 CDS YP_002407398.1 218699769 7153583 complement(1462418..1463791) 1 NC_011750.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1463791 mdtK 7153583 mdtK Escherichia coli IAI39 multidrug efflux protein YP_002407398.1 1462418 R 585057 CDS YP_002407399.1 218699770 7152038 1464006..1464647 1 NC_011750.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1464647 ribC 7152038 ribC Escherichia coli IAI39 riboflavin synthase subunit alpha YP_002407399.1 1464006 D 585057 CDS YP_002407400.1 218699771 7152627 complement(1464687..1465835) 1 NC_011750.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane fatty acyl phospholipid synthase 1465835 cfa 7152627 cfa Escherichia coli IAI39 cyclopropane fatty acyl phospholipid synthase YP_002407400.1 1464687 R 585057 CDS YP_002407401.1 218699772 7150924 complement(1466126..1467337) 1 NC_011750.1 uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 1467337 ydhC 7150924 ydhC Escherichia coli IAI39 inner membrane transport protein YdhC YP_002407401.1 1466126 R 585057 CDS YP_002407402.1 218699773 7153574 1467450..1468382 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2404765; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1468382 ydhB 7153574 ydhB Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002407402.1 1467450 D 585057 CDS YP_002407403.1 218699774 7153573 complement(1468379..1469404) 1 NC_011750.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 1469404 purR 7153573 purR Escherichia coli IAI39 DNA-binding transcriptional repressor PurR YP_002407403.1 1468379 R 585057 CDS YP_002407404.1 218699775 7152534 1469958..1471127 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative efflux protein; MFS family 1471127 ydhP 7152534 ydhP Escherichia coli IAI39 putative efflux protein; MFS family YP_002407404.1 1469958 D 585057 CDS YP_002407405.1 218699776 7153582 complement(1471273..1471854) 1 NC_011750.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 1471854 sodB 7153582 sodB Escherichia coli IAI39 superoxide dismutase YP_002407405.1 1471273 R 585057 CDS YP_002407406.1 218699777 7152871 complement(1471982..1472809) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported hydrolase 1472809 ydhO 7152871 ydhO Escherichia coli IAI39 putative exported hydrolase YP_002407406.1 1471982 R 585057 CDS YP_002407407.1 218699778 7153581 1473144..1473491 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15833738, 15840565, 11950925, 12730244; Product type e : enzyme; hypothetical protein 1473491 ydhD 7153581 ydhD Escherichia coli IAI39 hypothetical protein YP_002407407.1 1473144 D 585057 CDS YP_002407408.1 218699779 7153575 complement(1473542..1478158) 1 NC_011750.1 similar to the DNA and RNA helicase superfamily II and eukaryotic DEAD family of helicases; longest known protein in E. coli; putative ATP-dependent helicase Lhr 1478158 lhr 7153575 lhr Escherichia coli IAI39 putative ATP-dependent helicase Lhr YP_002407408.1 1473542 R 585057 CDS YP_002407409.1 218699780 7151934 complement(1478251..1478898) 1 NC_011750.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 1478898 rnt 7151934 rnt Escherichia coli IAI39 ribonuclease T YP_002407409.1 1478251 R 585057 CDS YP_002407410.1 218699781 7152663 complement(1479001..1479408) 1 NC_011750.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 1479408 gloA 7152663 gloA Escherichia coli IAI39 glyoxalase I YP_002407410.1 1479001 R 585057 CDS YP_002407411.1 218699782 7151534 complement(1479489..1480586) 1 NC_011750.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase 1480586 nemA 7151534 nemA Escherichia coli IAI39 N-ethylmaleimide reductase YP_002407411.1 1479489 R 585057 CDS YP_002407412.1 218699783 7152205 complement(1480623..1481138) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1481138 ydhM 7152205 ydhM Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002407412.1 1480623 R 585057 CDS YP_002407413.1 218699784 7153580 1481613..1482509 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1482509 ydhF 7153580 ydhF Escherichia coli IAI39 putative oxidoreductase YP_002407413.1 1481613 D 585057 CDS YP_002407414.1 218699785 7153576 1482589..1483110 1 NC_011750.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase 1483110 sodC 7153576 sodC Escherichia coli IAI39 superoxide dismutase YP_002407414.1 1482589 D 585057 CDS YP_002407415.1 218699786 7152872 complement(1483111..1485123) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1485123 ydhK 7152872 ydhK Escherichia coli IAI39 hypothetical protein YP_002407415.1 1483111 R 585057 CDS YP_002407416.1 218699787 7153579 complement(1485123..1485980) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12900028; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase 1485980 ydhJ 7153579 ydhJ Escherichia coli IAI39 undecaprenyl pyrophosphate phosphatase YP_002407416.1 1485123 R 585057 CDS YP_002407417.1 218699788 7153578 complement(1485983..1486219) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1486219 ydhI 7153578 ydhI Escherichia coli IAI39 hypothetical protein YP_002407417.1 1485983 R 585057 CDS YP_002407418.1 218699789 7153577 1486420..1486854 1 NC_011750.1 Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA 1486854 slyA 7153577 slyA Escherichia coli IAI39 transcriptional regulator SlyA YP_002407418.1 1486420 D 585057 CDS YP_002407419.1 218699790 7152860 complement(1486901..1487368) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8544813; Product type lp : lipoprotein; putative outer membrane lipoprotein 1487368 slyB 7152860 slyB Escherichia coli IAI39 putative outer membrane lipoprotein YP_002407419.1 1486901 R 585057 CDS YP_002407420.1 218699791 7152861 1487642..1488751 1 NC_011750.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 1488751 anmK 7152861 anmK Escherichia coli IAI39 anhydro-N-acetylmuramic acid kinase YP_002407420.1 1487642 D 585057 CDS YP_002407421.1 218699792 7150736 1488849..1489178 1 NC_011750.1 MliC; membrane-bound lysozyme inhibitor of c-type lysozyme; lysozyme inhibitor 1489178 ydhA 7150736 ydhA Escherichia coli IAI39 lysozyme inhibitor YP_002407421.1 1488849 D 585057 CDS YP_002407422.1 218699793 7153572 1489237..1489893 1 NC_011750.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 1489893 pdxH 7153572 pdxH Escherichia coli IAI39 pyridoxamine 5'-phosphate oxidase YP_002407422.1 1489237 D 585057 CDS YP_002407423.1 218699794 7152357 1490022..1491296 1 NC_011750.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1491296 tyrS 7152357 tyrS Escherichia coli IAI39 tyrosyl-tRNA synthetase YP_002407423.1 1490022 D 585057 CDS YP_002407424.1 218699795 7153066 1491355..1492218 1 NC_011750.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 1492218 pdxY 7153066 pdxY Escherichia coli IAI39 pyridoxamine kinase YP_002407424.1 1491355 D 585057 CDS YP_002407425.1 218699796 7152360 complement(1492262..1492867) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95096109, 2185038, 9680481; Product type e : enzyme; glutathionine S-transferase 1492867 gst 7152360 gst Escherichia coli IAI39 glutathionine S-transferase YP_002407425.1 1492262 R 585057 CDS YP_002407426.1 218699797 7151595 complement(1492973..1494475) 1 NC_011750.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; putative tripeptide transporter permease 1494475 tppB 7151595 tppB Escherichia coli IAI39 putative tripeptide transporter permease YP_002407426.1 1492973 R 585057 CDS YP_002407427.1 218699798 7153570 complement(1494758..1494958) 1 NC_011750.1 hypothetical protein 1494958 7153570 ECIAI39_1422 Escherichia coli IAI39 hypothetical protein YP_002407427.1 1494758 R 585057 CDS YP_002407428.1 218699799 7149727 complement(1495086..1495721) 1 NC_011750.1 DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III 1495721 nth 7149727 nth Escherichia coli IAI39 endonuclease III YP_002407428.1 1495086 R 585057 CDS YP_002407429.1 218699800 7152261 complement(1495721..1496416) 1 NC_011750.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex RsxE subunit 1496416 rsxE 7152261 rsxE Escherichia coli IAI39 electron transport complex RsxE subunit YP_002407429.1 1495721 R 585057 CDS YP_002407430.1 218699801 7152756 complement(1496420..1497040) 1 NC_011750.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 1497040 rsxG 7152756 rsxG Escherichia coli IAI39 electron transport complex protein RnfG YP_002407430.1 1496420 R 585057 CDS YP_002407431.1 218699802 7152757 complement(1497044..1498102) 1 NC_011750.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 1498102 rnfD 7152757 rnfD Escherichia coli IAI39 electron transport complex protein RnfD YP_002407431.1 1497044 R 585057 CDS YP_002407432.1 218699803 7152755 complement(1498103..1500325) 1 NC_011750.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 1500325 rsxC 7152755 rsxC Escherichia coli IAI39 electron transport complex protein RnfC YP_002407432.1 1498103 R 585057 CDS YP_002407433.1 218699804 7152754 complement(1500318..1500896) 1 NC_011750.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 1500896 rsxB 7152754 rsxB Escherichia coli IAI39 electron transport complex protein RnfB YP_002407433.1 1500318 R 585057 CDS YP_002407434.1 218699805 7152753 complement(1500896..1501477) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411911, 10637328, 12773378; Product type pm : putative membrane component; Na(+)-translocating NADH-quinone reductase subunit E 1501477 rsxA 7152753 rsxA Escherichia coli IAI39 Na(+)-translocating NADH-quinone reductase subunit E YP_002407434.1 1500896 R 585057 CDS YP_002407435.1 218699806 7152752 complement(1501554..1501994) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1501994 ydgK 7152752 ydgK Escherichia coli IAI39 hypothetical protein YP_002407435.1 1501554 R 585057 CDS YP_002407436.1 218699807 7153569 complement(1502080..1502295) 1 NC_011750.1 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein 1502295 ydgT 7153569 ydgT Escherichia coli IAI39 oriC-binding nucleoid-associated protein YP_002407436.1 1502080 R 585057 CDS YP_002407437.1 218699808 7153571 complement(1502568..1502768) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20392465, 10931331; Product type m : membrane component; beta-lactam resistance membrane protein 1502768 blr 7153571 blr Escherichia coli IAI39 beta-lactam resistance membrane protein YP_002407437.1 1502568 R 585057 CDS YP_002407438.1 218699809 7150872 1502936..1503976 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1503976 ydgJ 7150872 ydgJ Escherichia coli IAI39 putative oxidoreductase YP_002407438.1 1502936 D 585057 CDS YP_002407439.1 218699810 7153568 complement(1504012..1505013) 1 NC_011750.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 1505013 add 7153568 add Escherichia coli IAI39 adenosine deaminase YP_002407439.1 1504012 R 585057 CDS YP_002407440.1 218699811 7150683 complement(1505117..1506289) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20164451, 7665481, 91310596; Product type e : enzyme; bifunctional beta-cystathionase, PLP-dependent and regulator of maltose regulon 1506289 malY 7150683 malY Escherichia coli IAI39 bifunctional beta-cystathionase, PLP-dependent and regulator of maltose regulon YP_002407440.1 1505117 R 585057 CDS YP_002407441.1 218699812 7152006 complement(1506299..1507891) 1 NC_011750.1 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional PTS system maltose and glucose-specific transporter subunits IICB 1507891 malX 7152006 malX Escherichia coli IAI39 bifunctional PTS system maltose and glucose-specific transporter subunits IICB YP_002407441.1 1506299 R 585057 CDS YP_002407442.1 218699813 7152005 1508066..1509094 1 NC_011750.1 regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI 1509094 malI 7152005 malI Escherichia coli IAI39 DNA-binding transcriptional repressor MalI YP_002407442.1 1508066 D 585057 CDS YP_002407443.1 218699814 7151998 1509236..1510582 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element 1510582 insG 7151998 insG Escherichia coli IAI39 putative IS4 transposase; KpLE2 phage-like element YP_002407443.1 1509236 D 585057 CDS YP_002407444.1 218699815 7151809 1510644..1511411 1 NC_011750.1 Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase 1511411 hdhA 7151809 hdhA Escherichia coli IAI39 7-alpha-hydroxysteroid dehydrogenase YP_002407444.1 1510644 D 585057 CDS YP_002407445.1 218699816 7151622 1511632..1512222 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88038341, 2823062, 3934044, 11115104; Product type r : regulator; DNA-binding transcriptional repressor 1512222 uidR 7151622 uidR Escherichia coli IAI39 DNA-binding transcriptional repressor YP_002407445.1 1511632 D 585057 CDS YP_002407446.1 218699817 7153093 1512614..1514425 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87041472, 88038341, 2103475, 8125312; Product type e : enzyme; beta-D-glucuronidase 1514425 uidA 7153093 uidA Escherichia coli IAI39 beta-D-glucuronidase YP_002407446.1 1512614 D 585057 CDS YP_002407447.1 218699818 7153090 1514422..1515795 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3534890; Product type t : transporter; glucuronide transporter 1515795 uidB 7153090 uidB Escherichia coli IAI39 glucuronide transporter YP_002407447.1 1514422 D 585057 CDS YP_002407448.1 218699819 7153091 1515834..1517099 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15774881; Product type t : transporter; putative outer membrane porin protein 1517099 uidC 7153091 uidC Escherichia coli IAI39 putative outer membrane porin protein YP_002407448.1 1515834 D 585057 CDS YP_002407449.1 218699820 7153092 complement(1517144..1518652) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1518652 ydgA 7153092 ydgA Escherichia coli IAI39 hypothetical protein YP_002407449.1 1517144 R 585057 CDS YP_002407450.1 218699821 7153562 complement(1518753..1519928) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82100097, 6397402; Product type e : enzyme; mannose-6-phosphate isomerase 1519928 manA 7153562 manA Escherichia coli IAI39 mannose-6-phosphate isomerase YP_002407450.1 1518753 R 585057 CDS YP_002407451.1 218699822 7152008 1520127..1521773 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88193096, 88268900, 92011457, 3005475, 6328431, 9298646; Product type e : enzyme; fumarate hydratase 1521773 fumA 7152008 fumA Escherichia coli IAI39 fumarate hydratase YP_002407451.1 1520127 D 585057 CDS YP_002407452.1 218699823 7151453 1521916..1523319 1 NC_011750.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1523319 fumC 7151453 fumC Escherichia coli IAI39 fumarate hydratase YP_002407452.1 1521916 D 585057 CDS YP_002407453.1 218699824 7151455 complement(1523316..1524245) 1 NC_011750.1 binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 1524245 tus 7151455 tus Escherichia coli IAI39 DNA replication terminus site-binding protein YP_002407453.1 1523316 R 585057 CDS YP_002407454.1 218699825 7153056 complement(1524321..1525622) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93086426, 1495392, 1925016, 2646639; Product type r : regulator; sensor protein RstB 1525622 rstB 7153056 rstB Escherichia coli IAI39 sensor protein RstB YP_002407454.1 1524321 R 585057 CDS YP_002407455.1 218699826 7152750 complement(1525626..1526354) 1 NC_011750.1 response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 1526354 rstA 7152750 rstA Escherichia coli IAI39 DNA-binding transcriptional regulator RstA YP_002407455.1 1525626 R 585057 CDS YP_002407456.1 218699827 7152749 1526474..1526809 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1526809 ydgC 7152749 ydgC Escherichia coli IAI39 hypothetical protein YP_002407456.1 1526474 D 585057 CDS YP_002407457.1 218699828 7153563 complement(1526806..1527528) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14617668; Product type e : enzyme; short chain dehydrogenase 1527528 folM 7153563 folM Escherichia coli IAI39 short chain dehydrogenase YP_002407457.1 1526806 R 585057 CDS YP_002407458.1 218699829 7151403 complement(1527565..1528947) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1311296; Product type pt : putative transporter; putative arginine/ornithine antiporter transporter 1528947 ydgI 7151403 ydgI Escherichia coli IAI39 putative arginine/ornithine antiporter transporter YP_002407458.1 1527565 R 585057 CDS YP_002407459.1 218699830 7153567 complement(1529133..1530077) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1530077 ydgH 7153567 ydgH Escherichia coli IAI39 hypothetical protein YP_002407459.1 1529133 R 585057 CDS YP_002407460.1 218699831 7153566 1530602..1532134 1 NC_011750.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 1532134 pntA 7153566 pntA Escherichia coli IAI39 NAD(P) transhydrogenase subunit alpha YP_002407460.1 1530602 D 585057 CDS YP_002407461.1 218699832 7152436 1532145..1533533 1 NC_011750.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 1533533 pntB 7152436 pntB Escherichia coli IAI39 pyridine nucleotide transhydrogenase YP_002407461.1 1532145 D 585057 CDS YP_002407462.1 218699833 7152437 complement(1533558..1534592) 1 NC_011750.1 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; putative transport protein 1534592 tqsA 7152437 tqsA Escherichia coli IAI39 putative transport protein YP_002407462.1 1533558 R 585057 CDS YP_002407463.1 218699834 7153565 1535004..1535369 1 NC_011750.1 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ 1535369 mdtJ 7153565 mdtJ Escherichia coli IAI39 multidrug efflux system protein MdtJ YP_002407463.1 1535004 D 585057 CDS YP_002407464.1 218699835 7152037 1535356..1535685 1 NC_011750.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI 1535685 mdtI 7152037 mdtI Escherichia coli IAI39 multidrug efflux system protein MdtI YP_002407464.1 1535356 D 585057 CDS YP_002407465.1 218699836 7152036 complement(1535724..1536545) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported metallopeptidase 1536545 ydgD 7152036 ydgD Escherichia coli IAI39 putative exported metallopeptidase YP_002407465.1 1535724 R 585057 CDS YP_002407466.1 218699837 7153564 complement(1536821..1537129) 1 NC_011750.1 required for growth and survival under moderately acid conditions; acid shock protein 1537129 asr 7153564 asr Escherichia coli IAI39 acid shock protein YP_002407466.1 1536821 R 585057 CDS YP_002407467.1 218699838 7150809 complement(1537553..1538806) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1538806 ynfM 7150809 ynfM Escherichia coli IAI39 putative MFS superfamily transporter YP_002407467.1 1537553 R 585057 CDS YP_002407468.1 218699839 7154426 1538913..1539806 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1539806 ynfL 7154426 ynfL Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002407468.1 1538913 D 585057 CDS YP_002407469.1 218699840 7154425 1539941..1541161 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10318813, 20490366, 6989798, 99340206, 99395104, 99398866, 7766024; Product type r : regulator; DNA-binding transcriptional repressor 1541161 dgsA 7154425 dgsA Escherichia coli IAI39 DNA-binding transcriptional repressor YP_002407469.1 1539941 D 585057 CDS YP_002407470.1 218699841 7151131 1541286..1541981 1 NC_011750.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; putative dithiobiotin synthetase 1541981 ynfK 7151131 ynfK Escherichia coli IAI39 putative dithiobiotin synthetase YP_002407470.1 1541286 D 585057 CDS YP_002407471.1 218699842 7154424 complement(1541934..1543190) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12384697; Product type pt : putative transporter; putative voltage-gated ClC-type chloride channel ClcB 1543190 clcB 7154424 clcB Escherichia coli IAI39 putative voltage-gated ClC-type chloride channel ClcB YP_002407471.1 1541934 R 585057 CDS YP_002407472.1 218699843 7150961 complement(1543384..1543998) 1 NC_011750.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1543998 dmsD 7150961 dmsD Escherichia coli IAI39 twin-argninine leader-binding protein DmsD YP_002407472.1 1543384 R 585057 CDS YP_002407473.1 218699844 7151152 complement(1544041..1544895) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type m : membrane component; oxidoreductase, membrane subunit 1544895 ynfH 7151152 ynfH Escherichia coli IAI39 oxidoreductase, membrane subunit YP_002407473.1 1544041 R 585057 CDS YP_002407474.1 218699845 7154423 complement(1544897..1545514) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type c : carrier; oxidoreductase, Fe-S subunit 1545514 ynfG 7154423 ynfG Escherichia coli IAI39 oxidoreductase, Fe-S subunit YP_002407474.1 1544897 R 585057 CDS YP_002407475.1 218699846 7154422 complement(1545525..1547948) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type e : enzyme; oxidoreductase subunit 1547948 ynfF 7154422 ynfF Escherichia coli IAI39 oxidoreductase subunit YP_002407475.1 1545525 R 585057 CDS YP_002407476.1 218699847 7154421 complement(1548009..1550435) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type e : enzyme; oxidoreductase subunit 1550435 ynfE 7154421 ynfE Escherichia coli IAI39 oxidoreductase subunit YP_002407476.1 1548009 R 585057 CDS YP_002407477.1 218699848 7154420 complement(1550634..1550939) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9868784; hypothetical protein 1550939 ynfD 7154420 ynfD Escherichia coli IAI39 hypothetical protein YP_002407477.1 1550634 R 585057 CDS YP_002407478.1 218699849 7154419 1551047..1551757 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1551757 ynfC 7154419 ynfC Escherichia coli IAI39 hypothetical protein YP_002407478.1 1551047 D 585057 CDS YP_002407479.1 218699850 7154418 complement(1551760..1552320) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94357898; Product type e : enzyme; spermidine N1-acetyltransferase 1552320 speG 7154418 speG Escherichia coli IAI39 spermidine N1-acetyltransferase YP_002407479.1 1551760 R 585057 CDS YP_002407480.1 218699851 7152885 complement(1552355..1552696) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1552696 ynfB 7152885 ynfB Escherichia coli IAI39 hypothetical protein YP_002407480.1 1552355 R 585057 CDS YP_002407481.1 218699852 7154417 1552831..1553157 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1553157 ynfA 7154417 ynfA Escherichia coli IAI39 hypothetical protein YP_002407481.1 1552831 D 585057 CDS YP_002407482.1 218699853 7154416 1553363..1554577 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 93341455, 94310441; Product type pe : putative enzyme; putative enolase/dehydratase 1554577 rspA 7154416 rspA Escherichia coli IAI39 putative enolase/dehydratase YP_002407482.1 1553363 D 585057 CDS YP_002407483.1 218699854 7152745 1554589..1555608 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7545940; Product type pe : putative enzyme; putative dehydrogenase 1555608 rspB 7152745 rspB Escherichia coli IAI39 putative dehydrogenase YP_002407483.1 1554589 D 585057 CDS YP_002407484.1 218699855 7152746 complement(1555796..1557091) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative defective integrase; Qin prophage 1557091 intQ 7152746 intQ Escherichia coli IAI39 putative defective integrase; Qin prophage YP_002407484.1 1555796 R 585057 CDS YP_002407485.1 218699856 7149728 1558080..1558406 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 1558406 7149728 ECIAI39_1482 Escherichia coli IAI39 transposase ORF A, IS629 YP_002407485.1 1558080 D 585057 CDS YP_002407486.1 218699857 7149729 1558403..1558885 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 1558885 7149729 ECIAI39_1483 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002407486.1 1558403 D 585057 CDS YP_002407487.1 218699858 7149730 1559477..1561000 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9353259, 10413481; Product type e : enzyme; Group II intron-encoded reverse transcriptase/maturase 1561000 7149730 ECIAI39_1484 Escherichia coli IAI39 Group II intron-encoded reverse transcriptase/maturase YP_002407487.1 1559477 D 585057 CDS YP_002407488.1 218699859 7150528 1561117..1561563 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 1561563 7150528 ECIAI39_1485 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002407488.1 1561117 D 585057 CDS YP_002407489.1 218699860 7149732 1561623..1562036 1 NC_011750.1 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; hypothetical protein 1562036 ydfX 7149732 ydfX Escherichia coli IAI39 hypothetical protein YP_002407489.1 1561623 D 585057 CDS YP_002407490.1 218699861 7153560 1561963..1562982 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1562982 7153560 ECIAI39_1487 Escherichia coli IAI39 hypothetical protein YP_002407490.1 1561963 D 585057 CDS YP_002407491.1 218699862 7149733 1563023..1563445 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1563445 7149733 ECIAI39_1488 Escherichia coli IAI39 hypothetical protein YP_002407491.1 1563023 D 585057 CDS YP_002407492.1 218699863 7149734 1563442..1563798 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1563798 7149734 ECIAI39_1489 Escherichia coli IAI39 hypothetical protein YP_002407492.1 1563442 D 585057 CDS YP_002407493.1 218699864 7149735 1564221..1564346 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1564346 7149735 ECIAI39_1490 Escherichia coli IAI39 hypothetical protein YP_002407493.1 1564221 D 585057 CDS YP_002407494.1 218699865 7149736 complement(1565105..1565287) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1565287 7149736 ECIAI39_1491 Escherichia coli IAI39 hypothetical protein YP_002407494.1 1565105 R 585057 CDS YP_002407495.1 218699866 7149737 1565465..1566688 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1566688 7149737 ECIAI39_1492 Escherichia coli IAI39 hypothetical protein YP_002407495.1 1565465 D 585057 CDS YP_002407496.1 218699867 7149738 1566750..1567052 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS600 1567052 insM 7149738 insM Escherichia coli IAI39 transposase ORF A, IS600 YP_002407496.1 1566750 D 585057 CDS YP_002407497.1 218699868 7151825 1567088..1567906 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 1567906 7151825 ECIAI39_1494 Escherichia coli IAI39 transposase ORF B, IS600 YP_002407497.1 1567088 D 585057 CDS YP_002407498.1 218699869 7149739 1567812..1568465 1 NC_011750.1 hypothetical protein 1568465 7149739 ECIAI39_1495 Escherichia coli IAI39 hypothetical protein YP_002407498.1 1567812 D 585057 CDS YP_002407499.1 218699870 7149740 complement(1568509..1569291) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase/IS protein 1569291 7149740 ECIAI39_1496 Escherichia coli IAI39 transposase/IS protein YP_002407499.1 1568509 R 585057 CDS YP_002407500.1 218699871 7149741 complement(1569288..1570310) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS100 1570310 7149741 ECIAI39_1497 Escherichia coli IAI39 transposase ORF A, IS100 YP_002407500.1 1569288 R 585057 CDS YP_002407501.1 218699872 7153558 complement(1571069..1571281) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9484881, 8022261, 9439003; Product type h : extrachromosomal origin; cold shock protein; Qin prophage 1571281 cspF 7153558 cspF Escherichia coli IAI39 cold shock protein; Qin prophage YP_002407501.1 1571069 R 585057 CDS YP_002407502.1 218699873 7151017 1571582..1571797 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293754, 94293756, 9439003; Product type h : extrachromosomal origin; cold shock protein; Qin prophage 1571797 cspB 7151017 cspB Escherichia coli IAI39 cold shock protein; Qin prophage YP_002407502.1 1571582 D 585057 CDS YP_002407503.1 218699874 7151013 1572551..1572766 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative S lysis protein; Qin prophage 1572766 essQ 7151013 essQ Escherichia coli IAI39 putative S lysis protein; Qin prophage YP_002407503.1 1572551 D 585057 CDS YP_002407504.1 218699875 7151241 1572771..1573082 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1573082 ydfR 7151241 ydfR Escherichia coli IAI39 hypothetical protein YP_002407504.1 1572771 D 585057 CDS YP_002407505.1 218699876 7153557 1573079..1573612 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated lysozyme; Qin prophage 1573612 ydfQ 7153557 ydfQ Escherichia coli IAI39 putative membrane-associated lysozyme; Qin prophage YP_002407505.1 1573079 D 585057 CDS YP_002407506.1 218699877 7153556 1573609..1574106 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1574106 ydfP 7153556 ydfP Escherichia coli IAI39 hypothetical protein YP_002407506.1 1573609 D 585057 CDS YP_002407507.1 218699878 7153555 1574469..1574681 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9484881; Product type h : extrachromosomal origin; cold shock protein; Qin prophage 1574681 cspI 7153555 cspI Escherichia coli IAI39 cold shock protein; Qin prophage YP_002407507.1 1574469 D 585057 CDS YP_002407508.1 218699879 7151020 1575355..1575528 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21429224; Product type h : extrachromosomal origin; hypothetical protein 1575528 gnsB 7151020 gnsB Escherichia coli IAI39 hypothetical protein YP_002407508.1 1575355 D 585057 CDS YP_002407509.1 218699880 7151568 complement(1575680..1576090) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1576090 ydfO 7151568 ydfO Escherichia coli IAI39 hypothetical protein YP_002407509.1 1575680 R 585057 CDS YP_002407510.1 218699881 7153554 1576770..1577315 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92334985; Product type h : extrachromosomal origin; DNA packaging protein; DLP12 prophage 1577315 nohB 7153554 nohB Escherichia coli IAI39 DNA packaging protein; DLP12 prophage YP_002407510.1 1576770 D 585057 CDS YP_002407511.1 218699882 7152239 1577290..1579215 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; terminase large subunit from bacteriophage origin 1579215 A 7152239 A Escherichia coli IAI39 terminase large subunit from bacteriophage origin YP_002407511.1 1577290 D 585057 CDS YP_002407512.1 218699883 7150639 1579212..1579418 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11302702; Product type h : extrachromosomal origin; head-to-tail joining protein W (gpW) from bacteriophage origin 1579418 W 7150639 W Escherichia coli IAI39 head-to-tail joining protein W (gpW) from bacteriophage origin YP_002407512.1 1579212 D 585057 CDS YP_002407513.1 218699884 7153132 1579415..1581016 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin; Portal protein B (minor capsid protein B) from bacteriophage origin 1581016 B 7153132 B Escherichia coli IAI39 Portal protein B (minor capsid protein B) from bacteriophage origin YP_002407513.1 1579415 D 585057 CDS YP_002407514.1 218699885 7150832 1580862..1582328 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin; minor capsid protein C from bacteriophage origin 1582328 C 7150832 C Escherichia coli IAI39 minor capsid protein C from bacteriophage origin YP_002407514.1 1580862 D 585057 CDS YP_002407515.1 218699886 7150884 1582338..1582670 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6233140; Product type h : extrachromosomal origin; head decoration protein (major capsid protein D) from bacteriophage origin 1582670 D 7150884 D Escherichia coli IAI39 head decoration protein (major capsid protein D) from bacteriophage origin YP_002407515.1 1582338 D 585057 CDS YP_002407516.1 218699887 7151074 1582726..1583751 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin; major head protein 1583751 7151074 ECIAI39_1514 Escherichia coli IAI39 major head protein YP_002407516.1 1582726 D 585057 CDS YP_002407517.1 218699888 7149743 1583754..1584116 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; DNA packaging protein from bacteriophage origin 1584116 fI 7149743 fI Escherichia coli IAI39 DNA packaging protein from bacteriophage origin YP_002407517.1 1583754 D 585057 CDS YP_002407518.1 218699889 7151322 complement(1584109..1584549) 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS3 family 1584549 7151322 ECIAI39_1516 Escherichia coli IAI39 transposase ORF B (fragment), IS3 family YP_002407518.1 1584109 R 585057 CDS YP_002407519.1 218699890 7150529 complement(1584678..1586201) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9353259, 10413481; Product type e : enzyme; Group II intron-encoded reverse transcriptase/maturase 1586201 7150529 ECIAI39_1517 Escherichia coli IAI39 Group II intron-encoded reverse transcriptase/maturase YP_002407519.1 1584678 R 585057 CDS YP_002407520.1 218699891 7149745 complement(1586793..1587275) 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 1587275 7149745 ECIAI39_1518 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002407520.1 1586793 R 585057 CDS YP_002407521.1 218699892 7149746 complement(1587272..1587598) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 1587598 7149746 ECIAI39_1519 Escherichia coli IAI39 transposase ORF A, IS629 YP_002407521.1 1587272 R 585057 CDS YP_002407522.1 218699893 7151836 complement(1589112..1590848) 1 NC_011750.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter 1590848 cvrA 7151836 cvrA Escherichia coli IAI39 potassium/proton antiporter YP_002407522.1 1589112 R 585057 CDS YP_002407523.1 218699894 7151037 complement(1590943..1591857) 1 NC_011750.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A 1591857 ldcA 7151037 ldcA Escherichia coli IAI39 L,D-carboxypeptidase A YP_002407523.1 1590943 R 585057 CDS YP_002407524.1 218699895 7151917 1591957..1592568 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98317285; Product type e : enzyme; lytic murein endotransglycosylase E 1592568 emtA 7151917 emtA Escherichia coli IAI39 lytic murein endotransglycosylase E YP_002407524.1 1591957 D 585057 CDS YP_002407525.1 218699896 7151219 complement(1592570..1593304) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11031114; Product type cp : cell process; flagellar function protein 1593304 ycgR 7151219 ycgR Escherichia coli IAI39 flagellar function protein YP_002407525.1 1592570 R 585057 CDS YP_002407526.1 218699897 7153471 1593505..1593759 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative inner membrane protein with transglycosylase-associated domain 1593759 ymgE 7153471 ymgE Escherichia coli IAI39 putative inner membrane protein with transglycosylase-associated domain YP_002407526.1 1593505 D 585057 CDS YP_002407527.1 218699898 7154397 complement(1593809..1595800) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative outer membrane receptor 1595800 prrA 7154397 prrA Escherichia coli IAI39 putative outer membrane receptor YP_002407527.1 1593809 R 585057 CDS YP_002407528.1 218699899 7152498 complement(1595805..1596659) 1 NC_011750.1 involved in molybdenum transport; molybdenum transport protein ModD 1596659 modD 7152498 modD Escherichia coli IAI39 molybdenum transport protein ModD YP_002407528.1 1595805 R 585057 CDS YP_002407529.1 218699900 7152105 complement(1596656..1597468) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative SAM-dependent methyltransferase 1597468 7152105 ECIAI39_1529 Escherichia coli IAI39 putative SAM-dependent methyltransferase YP_002407529.1 1596656 R 585057 CDS YP_002407530.1 218699901 7149748 complement(1597478..1598236) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ABC transporter ATP-binding protein 1598236 7149748 ECIAI39_1530 Escherichia coli IAI39 putative ABC transporter ATP-binding protein YP_002407530.1 1597478 R 585057 CDS YP_002407531.1 218699902 7149749 complement(1598233..1599213) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative ABC transporter permease 1599213 7149749 ECIAI39_1531 Escherichia coli IAI39 putative ABC transporter permease YP_002407531.1 1598233 R 585057 CDS YP_002407532.1 218699903 7149750 complement(1599213..1600277) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter periplasmic binding protein 1600277 7149750 ECIAI39_1532 Escherichia coli IAI39 putative ABC transporter periplasmic binding protein YP_002407532.1 1599213 R 585057 CDS YP_002407533.1 218699904 7149751 complement(1600565..1602262) 1 NC_011750.1 periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell; trehalase 1602262 treA 7149751 treA Escherichia coli IAI39 trehalase YP_002407533.1 1600565 R 585057 CDS YP_002407534.1 218699905 7153017 complement(1602582..1604000) 1 NC_011750.1 phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL; dihydroxyacetone kinase subunit M 1604000 dhaH 7153017 dhaH Escherichia coli IAI39 dihydroxyacetone kinase subunit M YP_002407534.1 1602582 R 585057 CDS YP_002407535.1 218699906 7151133 complement(1604011..1604643) 1 NC_011750.1 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL 1604643 dhaL 7151133 dhaL Escherichia coli IAI39 dihydroxyacetone kinase subunit DhaL YP_002407535.1 1604011 R 585057 CDS YP_002407536.1 218699907 7151135 complement(1604654..1605724) 1 NC_011750.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 1605724 dhaK 7151135 dhaK Escherichia coli IAI39 dihydroxyacetone kinase subunit DhaK YP_002407536.1 1604654 R 585057 CDS YP_002407537.1 218699908 7151134 1605952..1607871 1 NC_011750.1 Positively regulates the dhaKLM operon from a sigma-70 promoter; DNA-binding transcriptional regulator DhaR 1607871 dhaR 7151134 dhaR Escherichia coli IAI39 DNA-binding transcriptional regulator DhaR YP_002407537.1 1605952 D 585057 CDS YP_002407538.1 218699909 7151136 complement(1607908..1608138) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1608138 7151136 ECIAI39_1538 Escherichia coli IAI39 hypothetical protein YP_002407538.1 1607908 R 585057 CDS YP_002407539.1 218699910 7149752 complement(1608276..1609367) 1 NC_011750.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 1609367 ychF 7149752 ychF Escherichia coli IAI39 GTP-dependent nucleic acid-binding protein EngD YP_002407539.1 1608276 R 585057 CDS YP_002407540.1 218699911 7153476 complement(1609484..1610068) 1 NC_011750.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 1610068 pth 7153476 pth Escherichia coli IAI39 peptidyl-tRNA hydrolase YP_002407540.1 1609484 R 585057 CDS YP_002407541.1 218699912 7152514 1610346..1610624 1 NC_011750.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 1610624 ychH 7152514 ychH Escherichia coli IAI39 hypothetical protein YP_002407541.1 1610346 D 585057 CDS YP_002407542.1 218699913 7153477 complement(1610679..1612358) 1 NC_011750.1 putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; putative sulfate transporter YchM 1612358 ychM 7153477 ychM Escherichia coli IAI39 putative sulfate transporter YchM YP_002407542.1 1610679 R 585057 CDS YP_002407543.1 218699914 7153479 complement(1612483..1613430) 1 NC_011750.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1613430 prsA 7153479 prsA Escherichia coli IAI39 ribose-phosphate pyrophosphokinase YP_002407543.1 1612483 R 585057 CDS YP_002407544.1 218699915 7152499 complement(1613581..1614432) 1 NC_011750.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1614432 ipk 7152499 ipk Escherichia coli IAI39 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_002407544.1 1613581 R 585057 CDS YP_002407545.1 218699916 7151854 complement(1614432..1615055) 1 NC_011750.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB 1615055 lolB 7151854 lolB Escherichia coli IAI39 outer membrane lipoprotein LolB YP_002407545.1 1614432 R 585057 CDS YP_002407546.1 218699917 7151951 1615269..1616525 1 NC_011750.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1616525 hemA 7151951 hemA Escherichia coli IAI39 glutamyl-tRNA reductase YP_002407546.1 1615269 D 585057 CDS YP_002407547.1 218699918 7151624 1616567..1617649 1 NC_011750.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1617649 prfA 7151624 prfA Escherichia coli IAI39 peptide chain release factor 1 YP_002407547.1 1616567 D 585057 CDS YP_002407548.1 218699919 7152472 1617649..1618482 1 NC_011750.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1618482 prmC 7152472 prmC Escherichia coli IAI39 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_002407548.1 1617649 D 585057 CDS YP_002407549.1 218699920 7152482 1618479..1618871 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10322010; Product type pr : putative regulator; putative transcriptional regulator 1618871 ychQ 7152482 ychQ Escherichia coli IAI39 putative transcriptional regulator YP_002407549.1 1618479 D 585057 CDS YP_002407550.1 218699921 7153482 1618875..1619684 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10322010; Product type pr : putative regulator; putative transcriptional regulator 1619684 ychA 7153482 ychA Escherichia coli IAI39 putative transcriptional regulator YP_002407550.1 1618875 D 585057 CDS YP_002407551.1 218699922 7153474 1619720..1620574 1 NC_011750.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1620574 kdsA 7153474 kdsA Escherichia coli IAI39 2-dehydro-3-deoxyphosphooctonate aldolase YP_002407551.1 1619720 D 585057 CDS YP_002407552.1 218699923 7151885 complement(1620723..1620830) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type f : factor; toxic polypeptide, small 1620830 ldrB 7151885 ldrB Escherichia coli IAI39 toxic polypeptide, small YP_002407552.1 1620723 R 585057 CDS YP_002407553.1 218699924 7152583 complement(1621258..1621425) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; small toxic polypeptide 1621425 ldrB 7152583 ldrB Escherichia coli IAI39 small toxic polypeptide YP_002407553.1 1621258 R 585057 CDS YP_002407554.1 218699925 7152584 complement(1621771..1622871) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93266586, 94193576, 94292460; Product type t : transporter; calcium/sodium:proton antiporter 1622871 chaA 7152584 chaA Escherichia coli IAI39 calcium/sodium:proton antiporter YP_002407554.1 1621771 R 585057 CDS YP_002407555.1 218699926 7150925 1623141..1623371 1 NC_011750.1 in Escherichia coli this protein putatively regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1623371 chaB 7150925 chaB Escherichia coli IAI39 cation transport regulator YP_002407555.1 1623141 D 585057 CDS YP_002407556.1 218699927 7150926 1623508..1624224 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type r : regulator; regulatory protein for cation transport 1624224 chaC 7150926 chaC Escherichia coli IAI39 regulatory protein for cation transport YP_002407556.1 1623508 D 585057 CDS YP_002407557.1 218699928 7150927 complement(1624268..1624621) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1624621 ychN 7150927 ychN Escherichia coli IAI39 hypothetical protein YP_002407557.1 1624268 R 585057 CDS YP_002407558.1 218699929 7153480 1624947..1626200 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pf : putative factor; hypothetical protein 1626200 ychP 7153480 ychP Escherichia coli IAI39 hypothetical protein YP_002407558.1 1624947 D 585057 CDS YP_002407559.1 218699930 7153481 complement(1626201..1626851) 1 NC_011750.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL 1626851 narL 7153481 narL Escherichia coli IAI39 transcriptional regulator NarL YP_002407559.1 1626201 R 585057 CDS YP_002407560.1 218699931 7152193 complement(1626844..1628640) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92276349, 92374842, 94083940, 2649492, 2657652, 2668029; Product type r : regulator; nitrate/nitrite sensor protein NarX 1628640 narX 7152193 narX Escherichia coli IAI39 nitrate/nitrite sensor protein NarX YP_002407560.1 1626844 R 585057 CDS YP_002407561.1 218699932 7152199 1628666..1628884 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1628884 7152199 ECIAI39_1561 Escherichia coli IAI39 hypothetical protein YP_002407561.1 1628666 D 585057 CDS YP_002407562.1 218699933 7149753 1628979..1630370 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91258310, 2657652, 2668029; Product type t : transporter; nitrate/nitrite transporter 1630370 narK 7149753 narK Escherichia coli IAI39 nitrate/nitrite transporter YP_002407562.1 1628979 D 585057 CDS YP_002407563.1 218699934 7152192 1630764..1634507 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 74167294, 89384449, 92121125, 2233673, 2668029, 2995309, 3053688, 3308846, 6094247; Product type e : enzyme; nitrate reductase 1 subunit alpha 1634507 narG 7152192 narG Escherichia coli IAI39 nitrate reductase 1 subunit alpha YP_002407563.1 1630764 D 585057 CDS YP_002407564.1 218699935 7152188 1634504..1636042 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 74167294, 89384449, 92121125, 1321049, 2832376, 3053688, 8383531, 8388253, 8664273, 9516445; Product type c : carrier; nitrate reductase 1, beta (Fe-S) subunit 1636042 narH 7152188 narH Escherichia coli IAI39 nitrate reductase 1, beta (Fe-S) subunit YP_002407564.1 1634504 D 585057 CDS YP_002407565.1 218699936 7152189 1636039..1636749 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89384449, 92121125, 9632249, 2832376; Product type f : factor; nitrate reductase 1 minormolybdenum-cofactor-assembly chaperone 1636749 narJ 7152189 narJ Escherichia coli IAI39 nitrate reductase 1 minormolybdenum-cofactor-assembly chaperone YP_002407565.1 1636039 D 585057 CDS YP_002407566.1 218699937 7152191 1636749..1637426 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 75114694, 89384449, 92121125, 2832376, 3053688; Product type c : carrier; nitrate reductase 1, gamma (cytochrome b(NR)) subunit 1637426 narI 7152191 narI Escherichia coli IAI39 nitrate reductase 1, gamma (cytochrome b(NR)) subunit YP_002407566.1 1636749 D 585057 CDS YP_002407567.1 218699938 7150616 complement(1637972..1638814) 1 NC_011750.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 1638814 purU 7150616 purU Escherichia coli IAI39 formyltetrahydrofolate deformylase YP_002407567.1 1637972 R 585057 CDS YP_002407568.1 218699939 7152536 complement(1638864..1639322) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1639322 ychJ 7152536 ychJ Escherichia coli IAI39 hypothetical protein YP_002407568.1 1638864 R 585057 CDS YP_002407569.1 218699940 7153478 1639396..1640340 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 1640340 rssA 7153478 rssA Escherichia coli IAI39 hypothetical protein YP_002407569.1 1639396 D 585057 CDS YP_002407570.1 218699941 7152747 1640432..1641445 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339606, 12912910, 9495753; Product type r : regulator; response regulator of RpoS 1641445 rssB 7152747 rssB Escherichia coli IAI39 response regulator of RpoS YP_002407570.1 1640432 D 585057 CDS YP_002407571.1 218699942 7152748 1641647..1642555 1 NC_011750.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalU 1642555 galU 7152748 galU Escherichia coli IAI39 UTP--glucose-1-phosphate uridylyltransferase subunit GalU YP_002407571.1 1641647 D 585057 CDS YP_002407572.1 218699943 7151478 complement(1642699..1643112) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 94335643, 95267838, 95286558, 99355427, 2404280, 11298273; Product type r : regulator; global DNA-binding transcriptional dual regulator H-NS 1643112 hns 7151478 hns Escherichia coli IAI39 global DNA-binding transcriptional dual regulator H-NS YP_002407572.1 1642699 R 585057 CDS YP_002407573.1 218699944 7151663 1643716..1644333 1 NC_011750.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1644333 tdk 7151663 tdk Escherichia coli IAI39 thymidine kinase YP_002407573.1 1643716 D 585057 CDS YP_002407574.1 218699945 7152962 complement(1644619..1645965) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element 1645965 insG 7152962 insG Escherichia coli IAI39 putative IS4 transposase; KpLE2 phage-like element YP_002407574.1 1644619 R 585057 CDS YP_002407575.1 218699946 7151810 complement(1646073..1648748) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12783863, 4301680, 89291706, 91200315; Product type e : enzyme; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1648748 adhE 7151810 adhE Escherichia coli IAI39 bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_002407575.1 1646073 R 585057 CDS YP_002407576.1 218699947 7150685 1649225..1649872 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1649872 ychE 7150685 ychE Escherichia coli IAI39 hypothetical protein YP_002407576.1 1649225 D 585057 CDS YP_002407577.1 218699948 7153475 complement(1650030..1650344) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1650344 7153475 ECIAI39_1577 Escherichia coli IAI39 hypothetical protein YP_002407577.1 1650030 R 585057 CDS YP_002407578.1 218699949 7149754 1650610..1652241 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20256410, 86111605, 90256748, 92325017, 2015910, 9298646, 9600841, 2187863, 8740179, 9740056, 10972807; Product type t : transporter; oligopeptide ABC transporter subunit periplasmic-binding protein 1652241 oppA 7149754 oppA Escherichia coli IAI39 oligopeptide ABC transporter subunit periplasmic-binding protein YP_002407578.1 1650610 D 585057 CDS YP_002407579.1 218699950 7152302 1652327..1653247 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606, 93106975, 2187863; Product type t : transporter; oligopeptide transporter permease 1653247 oppB 7152302 oppB Escherichia coli IAI39 oligopeptide transporter permease YP_002407579.1 1652327 D 585057 CDS YP_002407580.1 218699951 7152303 1653262..1654170 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide ABC transporter membrane protein 1654170 oppC 7152303 oppC Escherichia coli IAI39 oligopeptide ABC transporter membrane protein YP_002407580.1 1653262 D 585057 CDS YP_002407581.1 218699952 7152304 1654182..1655195 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide transporter ATP-binding protein 1655195 oppD 7152304 oppD Escherichia coli IAI39 oligopeptide transporter ATP-binding protein YP_002407581.1 1654182 D 585057 CDS YP_002407582.1 218699953 7152305 1655192..1656196 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide ABC transporter ATP-binding protein 1656196 oppF 7152305 oppF Escherichia coli IAI39 oligopeptide ABC transporter ATP-binding protein YP_002407582.1 1655192 D 585057 CDS YP_002407583.1 218699954 7152306 complement(1656249..1656578) 1 NC_011750.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 1656578 yciU 7152306 yciU Escherichia coli IAI39 dsDNA-mimic protein YP_002407583.1 1656249 R 585057 CDS YP_002407584.1 218699955 7153497 complement(1656613..1658073) 1 NC_011750.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase 1658073 cls 7153497 cls Escherichia coli IAI39 cardiolipin synthetase YP_002407584.1 1656613 R 585057 CDS YP_002407585.1 218699956 7150968 1658105..1658389 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1658389 7150968 ECIAI39_1585 Escherichia coli IAI39 hypothetical protein YP_002407585.1 1658105 D 585057 CDS YP_002407586.1 218699957 7149755 complement(1658444..1659697) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12220501, 12912904, 94224769, 98319474; Product type t : transporter; voltage-gated potassium channel 1659697 kch 7149755 kch Escherichia coli IAI39 voltage-gated potassium channel YP_002407586.1 1658444 R 585057 CDS YP_002407587.1 218699958 7151876 complement(1659997..1660293) 1 NC_011750.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; YciI-like protein 1660293 yciI 7151876 yciI Escherichia coli IAI39 YciI-like protein YP_002407587.1 1659997 R 585057 CDS YP_002407588.1 218699959 7153490 1660466..1661233 1 NC_011750.1 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transport protein TonB 1661233 tonB 7153490 tonB Escherichia coli IAI39 transport protein TonB YP_002407588.1 1660466 D 585057 CDS YP_002407589.1 218699960 7153001 complement(1661273..1661671) 1 NC_011750.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins; acyl-CoA thioester hydrolase 1661671 yciA 7153001 yciA Escherichia coli IAI39 acyl-CoA thioester hydrolase YP_002407589.1 1661273 R 585057 CDS YP_002407590.1 218699961 7153483 complement(1661776..1662315) 1 NC_011750.1 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 1662315 yciB 7153483 yciB Escherichia coli IAI39 intracellular septation protein A YP_002407590.1 1661776 R 585057 CDS YP_002407591.1 218699962 7153484 complement(1662345..1663088) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1663088 yciC 7153484 yciC Escherichia coli IAI39 hypothetical protein YP_002407591.1 1662345 R 585057 CDS YP_002407592.1 218699963 7153485 1663444..1664082 1 NC_011750.1 receptor for colicin S4; outer membrane protein W 1664082 ompW 7153485 ompW Escherichia coli IAI39 outer membrane protein W YP_002407592.1 1663444 D 585057 CDS YP_002407593.1 218699964 7152298 complement(1664141..1664599) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15388941, 3058546, 8455549; hypothetical protein 1664599 yciE 7152298 yciE Escherichia coli IAI39 hypothetical protein YP_002407593.1 1664141 R 585057 CDS YP_002407594.1 218699965 7153486 complement(1664693..1665193) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3058546, 8455549; hypothetical protein 1665193 yciF 7153486 yciF Escherichia coli IAI39 hypothetical protein YP_002407594.1 1664693 R 585057 CDS YP_002407595.1 218699966 7153487 complement(1665279..1665458) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1665458 yciG 7153487 yciG Escherichia coli IAI39 hypothetical protein YP_002407595.1 1665279 R 585057 CDS YP_002407596.1 218699967 7153488 complement(1665839..1666645) 1 NC_011750.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1666645 trpA 7153488 trpA Escherichia coli IAI39 tryptophan synthase subunit alpha YP_002407596.1 1665839 R 585057 CDS YP_002407597.1 218699968 7153031 complement(1666645..1667838) 1 NC_011750.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1667838 trpB 7153031 trpB Escherichia coli IAI39 tryptophan synthase subunit beta YP_002407597.1 1666645 R 585057 CDS YP_002407598.1 218699969 7153032 complement(1667850..1669208) 1 NC_011750.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1669208 trpC 7153032 trpC Escherichia coli IAI39 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase YP_002407598.1 1667850 R 585057 CDS YP_002407599.1 218699970 7153033 complement(1669212..1670807) 1 NC_011750.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase 1670807 trpD 7153033 trpD Escherichia coli IAI39 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase YP_002407599.1 1669212 R 585057 CDS YP_002407600.1 218699971 7153034 complement(1670807..1672369) 1 NC_011750.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1672369 trpE 7153034 trpE Escherichia coli IAI39 anthranilate synthase component I YP_002407600.1 1670807 R 585057 CDS YP_002407602.1 218699973 7153036 1672643..1673524 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1673524 yciV 7153036 yciV Escherichia coli IAI39 hypothetical protein YP_002407602.1 1672643 D 585057 CDS YP_002407603.1 218699974 7153498 1673521..1674141 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1674141 yciO 7153498 yciO Escherichia coli IAI39 hypothetical protein YP_002407603.1 1673521 D 585057 CDS YP_002407604.1 218699975 7153494 1674169..1676058 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1676058 yciQ 7153494 yciQ Escherichia coli IAI39 hypothetical protein YP_002407604.1 1674169 D 585057 CDS YP_002407605.1 218699976 7153495 1676269..1677144 1 NC_011750.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1677144 rluB 7153495 rluB Escherichia coli IAI39 23S rRNA pseudouridylate synthase B YP_002407605.1 1676269 D 585057 CDS YP_002407606.1 218699977 7152642 1677314..1678225 1 NC_011750.1 putative lipoprotein 1678225 7152642 ECIAI39_1606 Escherichia coli IAI39 putative lipoprotein YP_002407606.1 1677314 D 585057 CDS YP_002407607.1 218699978 7149756 1678325..1678633 1 NC_011750.1 hypothetical protein 1678633 7149756 ECIAI39_1607 Escherichia coli IAI39 hypothetical protein YP_002407607.1 1678325 D 585057 CDS YP_002407608.1 218699979 7149757 complement(1678686..1679276) 1 NC_011750.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 1679276 btuR 7149757 btuR Escherichia coli IAI39 cob(I)yrinic acid a,c-diamide adenosyltransferase YP_002407608.1 1678686 R 585057 CDS YP_002407609.1 218699980 7150883 complement(1679273..1680031) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; short chain dehydrogenase 1680031 yciK 7150883 yciK Escherichia coli IAI39 short chain dehydrogenase YP_002407609.1 1679273 R 585057 CDS YP_002407610.1 218699981 7153491 complement(1680075..1680239) 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 1680239 7153491 ECIAI39_1610 Escherichia coli IAI39 hypothetical protein YP_002407610.1 1680075 R 585057 CDS YP_002407611.1 218699982 7149758 1680251..1681300 1 NC_011750.1 SohB; periplasmic protein; member of the peptidase S49 family; putative periplasmic protease 1681300 sohB 7149758 sohB Escherichia coli IAI39 putative periplasmic protease YP_002407611.1 1680251 D 585057 CDS YP_002407612.1 218699983 7152874 complement(1681336..1681587) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3029379, 7567469, 9868784; hypothetical protein 1681587 yciN 7152874 yciN Escherichia coli IAI39 hypothetical protein YP_002407612.1 1681336 R 585057 CDS YP_002407613.1 218699984 7153493 1681967..1684564 1 NC_011750.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1684564 topA 7153493 topA Escherichia coli IAI39 DNA topoisomerase I YP_002407613.1 1681967 D 585057 CDS YP_002407614.1 218699985 7153002 1684774..1685748 1 NC_011750.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1685748 cysB 7153002 cysB Escherichia coli IAI39 transcriptional regulator CysB YP_002407614.1 1684774 D 585057 CDS YP_002407615.1 218699986 7151056 1686043..1686207 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1686207 7151056 ECIAI39_1615 Escherichia coli IAI39 hypothetical protein YP_002407615.1 1686043 D 585057 CDS YP_002407616.1 218699987 7149759 1686189..1686377 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1686377 7149759 ECIAI39_1616 Escherichia coli IAI39 hypothetical protein YP_002407616.1 1686189 D 585057 CDS YP_002407617.1 218699988 7149760 1686751..1689426 1 NC_011750.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1689426 acnA 7149760 acnA Escherichia coli IAI39 aconitate hydratase YP_002407617.1 1686751 D 585057 CDS YP_002407618.1 218699989 7150666 complement(1689490..1690080) 1 NC_011750.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 1690080 ribA 7150666 ribA Escherichia coli IAI39 GTP cyclohydrolase II YP_002407618.1 1689490 R 585057 CDS YP_002407619.1 218699990 7152625 1690250..1691014 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89033893, 92104964; Product type e : enzyme; phosphatidylglycerophosphatase B 1691014 pgpB 7152625 pgpB Escherichia coli IAI39 phosphatidylglycerophosphatase B YP_002407619.1 1690250 D 585057 CDS YP_002407620.1 218699991 7152386 1691163..1691471 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1691471 yciS 7152386 yciS Escherichia coli IAI39 hypothetical protein YP_002407620.1 1691163 D 585057 CDS YP_002407621.1 218699992 7153496 1691478..1692647 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; tetratricopeptide repeat protein 1692647 yciM 7153496 yciM Escherichia coli IAI39 tetratricopeptide repeat protein YP_002407621.1 1691478 D 585057 CDS YP_002407622.1 218699993 7153492 1692839..1693576 1 NC_011750.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1693576 pyrF 7153492 pyrF Escherichia coli IAI39 orotidine 5'-phosphate decarboxylase YP_002407622.1 1692839 D 585057 CDS YP_002407623.1 218699994 7152552 1693576..1693902 1 NC_011750.1 involved in start site selection during the initiation of translation; translation initiation factor Sui1 1693902 yciH 7152552 yciH Escherichia coli IAI39 translation initiation factor Sui1 YP_002407623.1 1693576 D 585057 CDS YP_002407624.1 218699995 7153489 complement(1694028..1694246) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92078100, 2644204; Product type lp : lipoprotein; lipoprotein 1694246 osmB 7153489 osmB Escherichia coli IAI39 lipoprotein YP_002407624.1 1694028 R 585057 CDS YP_002407625.1 218699996 7152308 complement(1694515..1695264) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16451192; Product type r : regulator; DeoR family DNA-binding transcriptional repressor 1695264 deoT 7152308 deoT Escherichia coli IAI39 DeoR family DNA-binding transcriptional repressor YP_002407625.1 1694515 R 585057 CDS YP_002407626.1 218699997 7151122 complement(1695354..1695569) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1695569 7151122 ECIAI39_1626 Escherichia coli IAI39 hypothetical protein YP_002407626.1 1695354 R 585057 CDS YP_002407627.1 218699998 7149761 complement(1695674..1697659) 1 NC_011750.1 c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP; RNase II stability modulator 1697659 gmr 7149761 gmr Escherichia coli IAI39 RNase II stability modulator YP_002407627.1 1695674 R 585057 CDS YP_002407628.1 218699999 7151565 complement(1697894..1699828) 1 NC_011750.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II 1699828 rnb 7151565 rnb Escherichia coli IAI39 exoribonuclease II YP_002407628.1 1697894 R 585057 CDS YP_002407629.1 218700000 7152652 complement(1699896..1701023) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amidase or amidotransferase 1701023 yciW 7152652 yciW Escherichia coli IAI39 putative amidase or amidotransferase YP_002407629.1 1699896 R 585057 CDS YP_002407630.1 218700001 7153499 complement(1701167..1701955) 1 NC_011750.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase 1701955 fabI 7153499 fabI Escherichia coli IAI39 enoyl-(acyl carrier protein) reductase YP_002407630.1 1701167 R 585057 CDS YP_002407631.1 218700002 7151269 1702075..1702257 1 NC_011750.1 hypothetical protein 1702257 7151269 ECIAI39_1631 Escherichia coli IAI39 hypothetical protein YP_002407631.1 1702075 D 585057 CDS YP_002407632.1 218700003 7149762 1702413..1703000 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional repressor 1703000 7149762 ECIAI39_1632 Escherichia coli IAI39 putative transcriptional repressor YP_002407632.1 1702413 D 585057 CDS YP_002407633.1 218700004 7149763 1703116..1704267 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative efflux protein, membrane fusion (MFP) family 1704267 7149763 ECIAI39_1633 Escherichia coli IAI39 putative efflux protein, membrane fusion (MFP) family YP_002407633.1 1703116 D 585057 CDS YP_002407634.1 218700005 7149764 1704319..1704645 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 1704645 7149764 ECIAI39_1634 Escherichia coli IAI39 transposase ORF A, IS629 YP_002407634.1 1704319 D 585057 CDS YP_002407635.1 218700006 7149765 1704642..1705124 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 1705124 7149765 ECIAI39_1635 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002407635.1 1704642 D 585057 CDS YP_002407636.1 218700007 7149766 1705716..1707239 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative reverse transcriptase-like protein from putative prophage or plasmid 1707239 7149766 ECIAI39_1636 Escherichia coli IAI39 putative reverse transcriptase-like protein from putative prophage or plasmid YP_002407636.1 1705716 D 585057 CDS YP_002407637.1 218700008 7150532 1707356..1707802 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 1707802 7150532 ECIAI39_1637 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002407637.1 1707356 D 585057 CDS YP_002407638.1 218700009 7149768 1707853..1710960 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative efflux pump 1710960 7149768 ECIAI39_1638 Escherichia coli IAI39 putative efflux pump YP_002407638.1 1707853 D 585057 CDS YP_002407639.1 218700010 7149769 1710964..1712337 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane channel protein of an efflux system 1712337 7149769 ECIAI39_1639 Escherichia coli IAI39 putative outer membrane channel protein of an efflux system YP_002407639.1 1710964 D 585057 CDS YP_002407640.1 218700011 7149770 1712346..1713509 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative membrane transport protein of an efflux system 1713509 7149770 ECIAI39_1640 Escherichia coli IAI39 putative membrane transport protein of an efflux system YP_002407640.1 1712346 D 585057 CDS YP_002407641.1 218700012 7149771 complement(1713557..1714363) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 10720487, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter ATP-binding protein 1714363 sapF 7149771 sapF Escherichia coli IAI39 antimicrobial peptide ABC transporter ATP-binding protein YP_002407641.1 1713557 R 585057 CDS YP_002407642.1 218700013 7152802 complement(1714365..1715357) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 10720487, 9634580, 1987159; Product type t : transporter; antimicrobial peptide ABC transporter ATP-binding protein 1715357 sapD 7152802 sapD Escherichia coli IAI39 antimicrobial peptide ABC transporter ATP-binding protein YP_002407642.1 1714365 R 585057 CDS YP_002407643.1 218700014 7152801 complement(1715357..1716247) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter permease 1716247 sapC 7152801 sapC Escherichia coli IAI39 antimicrobial peptide ABC transporter permease YP_002407643.1 1715357 R 585057 CDS YP_002407644.1 218700015 7152800 complement(1716234..1717199) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter permease 1717199 sapB 7152800 sapB Escherichia coli IAI39 antimicrobial peptide ABC transporter permease YP_002407644.1 1716234 R 585057 CDS YP_002407645.1 218700016 7152799 complement(1717196..1718839) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter periplasmic-binding protein 1718839 sapA 7152799 sapA Escherichia coli IAI39 antimicrobial peptide ABC transporter periplasmic-binding protein YP_002407645.1 1717196 R 585057 CDS YP_002407646.1 218700017 7152798 complement(1719152..1719397) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1719397 ymjA 7152798 ymjA Escherichia coli IAI39 hypothetical protein YP_002407646.1 1719152 R 585057 CDS YP_002407647.1 218700018 7154399 complement(1719531..1720916) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15590624; Product type t : transporter; putrescine importer 1720916 puuP 7154399 puuP Escherichia coli IAI39 putrescine importer YP_002407647.1 1719531 R 585057 CDS YP_002407648.1 218700019 7152544 complement(1721219..1722637) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15590624; Product type e : enzyme; gamma-Glu-putrescine synthase 1722637 puuA 7152544 puuA Escherichia coli IAI39 gamma-Glu-putrescine synthase YP_002407648.1 1721219 R 585057 CDS YP_002407649.1 218700020 7152539 1722849..1723613 1 NC_011750.1 catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate; gamma-glutamyl-gamma-aminobutyrate hydrolase 1723613 puuD 7152539 puuD Escherichia coli IAI39 gamma-glutamyl-gamma-aminobutyrate hydrolase YP_002407649.1 1722849 D 585057 CDS YP_002407650.1 218700021 7152542 1723640..1724197 1 NC_011750.1 regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR 1724197 puuR 7152542 puuR Escherichia coli IAI39 DNA-binding transcriptional repressor PuuR YP_002407650.1 1723640 D 585057 CDS YP_002407651.1 218700022 7152545 1724347..1725834 1 NC_011750.1 catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation; gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 1725834 puuC 7152545 puuC Escherichia coli IAI39 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase YP_002407651.1 1724347 D 585057 CDS YP_002407652.1 218700023 7152541 1725836..1727116 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150200, 15590624; Product type e : enzyme; gamma-Glu-putrescine oxidase, FAD/NAD(P)-binding 1727116 puuB 7152541 puuB Escherichia coli IAI39 gamma-Glu-putrescine oxidase, FAD/NAD(P)-binding YP_002407652.1 1725836 D 585057 CDS YP_002407653.1 218700024 7152540 1727154..1728419 1 NC_011750.1 putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate; 4-aminobutyrate transaminase 1728419 puuE 7152540 puuE Escherichia coli IAI39 4-aminobutyrate transaminase YP_002407653.1 1727154 D 585057 CDS YP_002407654.1 218700025 7152543 complement(1728550..1729527) 1 NC_011750.1 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator 1729527 pspF 7152543 pspF Escherichia coli IAI39 phage shock protein operon transcriptional activator YP_002407654.1 1728550 R 585057 CDS YP_002407655.1 218700026 7152507 1729694..1730362 1 NC_011750.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 1730362 pspA 7152507 pspA Escherichia coli IAI39 phage shock protein PspA YP_002407655.1 1729694 D 585057 CDS YP_002407656.1 218700027 7152502 1730416..1730640 1 NC_011750.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B 1730640 pspB 7152502 pspB Escherichia coli IAI39 phage shock protein B YP_002407656.1 1730416 D 585057 CDS YP_002407657.1 218700028 7152503 1730640..1730999 1 NC_011750.1 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; DNA-binding transcriptional activator PspC 1730999 pspC 7152503 pspC Escherichia coli IAI39 DNA-binding transcriptional activator PspC YP_002407657.1 1730640 D 585057 CDS YP_002407658.1 218700029 7152504 1731008..1731229 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91295203, 97303082; Product type ph : phenotype; peripheral inner membrane phage-shock protein 1731229 pspD 7152504 pspD Escherichia coli IAI39 peripheral inner membrane phage-shock protein YP_002407658.1 1731008 D 585057 CDS YP_002407659.1 218700030 7152505 1731304..1731618 1 NC_011750.1 rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 1731618 pspE 7152505 pspE Escherichia coli IAI39 thiosulfate:cyanide sulfurtransferase YP_002407659.1 1731304 D 585057 CDS YP_002407660.1 218700031 7152506 1731832..1733511 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glucosyltransferase 1733511 ycjM 7152506 ycjM Escherichia coli IAI39 putative glucosyltransferase YP_002407660.1 1731832 D 585057 CDS YP_002407661.1 218700032 7153502 complement(1733326..1733616) 1 NC_011750.1 hypothetical protein 1733616 7153502 ECIAI39_1661 Escherichia coli IAI39 hypothetical protein YP_002407661.1 1733326 R 585057 CDS YP_002407662.1 218700033 7149772 1733525..1734817 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter periplasmic-binding protein transporter 1734817 ycjN 7149772 ycjN Escherichia coli IAI39 putative sugar ABC transporter periplasmic-binding protein transporter YP_002407662.1 1733525 D 585057 CDS YP_002407663.1 218700034 7153503 1734838..1735719 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter permease 1735719 ycjO 7153503 ycjO Escherichia coli IAI39 putative sugar ABC transporter permease YP_002407663.1 1734838 D 585057 CDS YP_002407664.1 218700035 7153504 1735706..1736548 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter permease 1736548 ycjP 7153504 ycjP Escherichia coli IAI39 putative sugar ABC transporter permease YP_002407664.1 1735706 D 585057 CDS YP_002407665.1 218700036 7153505 1736579..1737631 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1737631 ycjQ 7153505 ycjQ Escherichia coli IAI39 putative oxidoreductase YP_002407665.1 1736579 D 585057 CDS YP_002407666.1 218700037 7153506 1737650..1738438 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative isomerase/epimerase 1738438 ycjR 7153506 ycjR Escherichia coli IAI39 putative isomerase/epimerase YP_002407666.1 1737650 D 585057 CDS YP_002407667.1 218700038 7153507 1738448..1739503 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1739503 ycjS 7153507 ycjS Escherichia coli IAI39 putative oxidoreductase YP_002407667.1 1738448 D 585057 CDS YP_002407668.1 218700039 7153508 1739500..1741767 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl hydrolase/phosphorylase 1741767 ycjT 7153508 ycjT Escherichia coli IAI39 putative glycosyl hydrolase/phosphorylase YP_002407668.1 1739500 D 585057 CDS YP_002407669.1 218700040 7153509 1741764..1742423 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11972617; Product type pe : putative enzyme; putative glucose-1-phosphate phosphodismutase 1742423 ycjU 7153509 ycjU Escherichia coli IAI39 putative glucose-1-phosphate phosphodismutase YP_002407669.1 1741764 D 585057 CDS YP_002407670.1 218700041 7153510 1742437..1743519 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter ATP-binding protein transporter 1743519 ycjV 7153510 ycjV Escherichia coli IAI39 putative sugar ABC transporter ATP-binding protein transporter YP_002407670.1 1742437 D 585057 CDS YP_002407671.1 218700042 7153511 1743564..1744469 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20464934, 89327119, 9721282; Product type t : transporter; outer membrane porin 1744469 ompG 7153511 ompG Escherichia coli IAI39 outer membrane porin YP_002407671.1 1743564 D 585057 CDS YP_002407672.1 218700043 7152293 complement(1744520..1745518) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1745518 ycjW 7152293 ycjW Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002407672.1 1744520 R 585057 CDS YP_002407673.1 218700044 7153512 1745662..1747059 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1747059 ycjX 7153512 ycjX Escherichia coli IAI39 hypothetical protein YP_002407673.1 1745662 D 585057 CDS YP_002407674.1 218700045 7153513 1747056..1748117 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1748117 ycjF 7153513 ycjF Escherichia coli IAI39 hypothetical protein YP_002407674.1 1747056 D 585057 CDS YP_002407675.1 218700046 7153500 1748265..1749806 1 NC_011750.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1749806 tyrR 7153500 tyrR Escherichia coli IAI39 DNA-binding transcriptional regulator TyrR YP_002407675.1 1748265 D 585057 CDS YP_002407676.1 218700047 7153065 complement(1749850..1750356) 1 NC_011750.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1750356 tpx 7153065 tpx Escherichia coli IAI39 thiol peroxidase YP_002407676.1 1749850 R 585057 CDS YP_002407677.1 218700048 7153016 1750475..1751440 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11747447, 11747448, 7499381; Product type e : enzyme; L-Ala-D/L-Glu epimerase 1751440 ycjG 7153016 ycjG Escherichia coli IAI39 L-Ala-D/L-Glu epimerase YP_002407677.1 1750475 D 585057 CDS YP_002407678.1 218700049 7153501 complement(1751415..1752203) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12511517; Product type e : enzyme; murein peptide amidase A 1752203 mpaA 7153501 mpaA Escherichia coli IAI39 murein peptide amidase A YP_002407678.1 1751415 R 585057 CDS YP_002407679.1 218700050 7152113 1752326..1753939 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438753, 9495761; Product type t : transporter; murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) ABC transporter subunit periplasmic-binding protein 1753939 mppA 7152113 mppA Escherichia coli IAI39 murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) ABC transporter subunit periplasmic-binding protein YP_002407679.1 1752326 D 585057 CDS YP_002407680.1 218700051 7152115 complement(1753990..1755021) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1755021 ynaI 7152115 ynaI Escherichia coli IAI39 hypothetical protein YP_002407680.1 1753990 R 585057 CDS YP_002407681.1 218700052 7154400 1755265..1755522 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1755522 ynaJ 7154400 ynaJ Escherichia coli IAI39 hypothetical protein YP_002407681.1 1755265 D 585057 CDS YP_002407682.1 218700053 7154401 complement(1755572..1756522) 1 NC_011750.1 with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 1756522 uspE 7154401 uspE Escherichia coli IAI39 universal stress protein UspE YP_002407682.1 1755572 R 585057 CDS YP_002407683.1 218700054 7153109 complement(1756674..1757426) 1 NC_011750.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 1757426 fnr 7153109 fnr Escherichia coli IAI39 fumarate/nitrate reduction transcriptional regulator YP_002407683.1 1756674 R 585057 CDS YP_002407684.1 218700055 7151394 complement(1757621..1758136) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88067749, 91161525, 94252990, 98125595, 1520330; Product type e : enzyme; O-6-alkylguanine-DNA:cysteine-protein methyltransferase 1758136 ogt 7151394 ogt Escherichia coli IAI39 O-6-alkylguanine-DNA:cysteine-protein methyltransferase YP_002407684.1 1757621 R 585057 CDS YP_002407685.1 218700056 7152289 complement(1758147..1759673) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9829935, 2825131, 7567469; Product type t : transporter; putative aminobenzoyl-glutamate transporter 1759673 abgT 7152289 abgT Escherichia coli IAI39 putative aminobenzoyl-glutamate transporter YP_002407685.1 1758147 R 585057 CDS YP_002407686.1 218700057 7150652 complement(1761144..1762454) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9829935; Product type pe : putative enzyme; putative peptidase, para-aminobenzoyl-glutamate utilization protein 1762454 abgA 7150652 abgA Escherichia coli IAI39 putative peptidase, para-aminobenzoyl-glutamate utilization protein YP_002407686.1 1761144 R 585057 CDS YP_002407687.1 218700058 7150650 1762630..1763538 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9829935; Product type r : regulator; putative DNA-binding transcriptional regulator 1763538 abgR 7150650 abgR Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002407687.1 1762630 D 585057 CDS YP_002407688.1 218700059 7151859 1763868..1764431 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1764431 ydaL 7151859 ydaL Escherichia coli IAI39 hypothetical protein YP_002407688.1 1763868 D 585057 CDS YP_002407689.1 218700060 7153514 complement(1764452..1765684) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16045609; Product type pe : putative enzyme; putative diguanylate cyclase, GG[D/E]EF domain signalling protein 1765684 ydaM 7153514 ydaM Escherichia coli IAI39 putative diguanylate cyclase, GG[D/E]EF domain signalling protein YP_002407689.1 1764452 R 585057 CDS YP_002407690.1 218700061 7153515 1765939..1766922 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; zinc transporter 1766922 zntB 7153515 zntB Escherichia coli IAI39 zinc transporter YP_002407690.1 1765939 D 585057 CDS YP_002407691.1 218700062 7153516 1767197..1767370 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1767370 7153516 ECIAI39_1693 Escherichia coli IAI39 hypothetical protein YP_002407691.1 1767197 D 585057 CDS YP_002407692.1 218700063 7150886 1767400..1768773 1 NC_011750.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA 1768773 dbpA 7150886 dbpA Escherichia coli IAI39 ATP-dependent RNA helicase DbpA YP_002407692.1 1767400 D 585057 CDS YP_002407693.1 218700064 7151089 complement(1768902..1769837) 1 NC_011750.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1769837 ydaO 7151089 ydaO Escherichia coli IAI39 C32 tRNA thiolase YP_002407693.1 1768902 R 585057 CDS YP_002407694.1 218700065 7153517 complement(1770013..1770447) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 12381839, 11849540, 9298646; Product type f : factor; stress-induced protein, ATP-binding protein 1770447 uspF 7153517 uspF Escherichia coli IAI39 stress-induced protein, ATP-binding protein YP_002407694.1 1770013 R 585057 CDS YP_002407695.1 218700066 7153110 complement(1770588..1771721) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9642192; Product type t : transporter; outer membrane pore protein N, non-specific 1771721 ompN 7153110 ompN Escherichia coli IAI39 outer membrane pore protein N, non-specific YP_002407695.1 1770588 R 585057 CDS YP_002407696.1 218700067 7152081 complement(1772082..1775606) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9025293; Product type pe : putative enzyme; putative 2-oxoacid-flavodoxin/oxidoreductase 1775606 ydbK 7152081 ydbK Escherichia coli IAI39 putative 2-oxoacid-flavodoxin/oxidoreductase YP_002407696.1 1772082 R 585057 CDS YP_002407697.1 218700068 7153523 1775880..1776146 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1776146 ydbJ 7153523 ydbJ Escherichia coli IAI39 hypothetical protein YP_002407697.1 1775880 D 585057 CDS YP_002407698.1 218700069 7153522 complement(1776143..1776613) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12892888, 8349564, 9025293; Product type f : factor; heat-inducible protein 1776613 hslJ 7153522 hslJ Escherichia coli IAI39 heat-inducible protein YP_002407698.1 1776143 R 585057 CDS YP_002407699.1 218700070 7151680 1776575..1776901 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 1776901 7151680 ECIAI39_1701 Escherichia coli IAI39 transposase ORF A, IS629 YP_002407699.1 1776575 D 585057 CDS YP_002407700.1 218700071 7149781 1776898..1777380 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 1777380 7149781 ECIAI39_1702 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002407700.1 1776898 D 585057 CDS YP_002407701.1 218700072 7149782 1777972..1779495 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative reverse transcriptase-like protein from putative prophage or plasmid 1779495 7149782 ECIAI39_1703 Escherichia coli IAI39 putative reverse transcriptase-like protein from putative prophage or plasmid YP_002407701.1 1777972 D 585057 CDS YP_002407702.1 218700073 7150533 1779612..1780058 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 1780058 7150533 ECIAI39_1704 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002407702.1 1779612 D 585057 CDS YP_002407703.1 218700074 7149784 complement(1780259..1781248) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4297266, 89123040, 90198524, 8349564, 9025293; Product type e : enzyme; fermentative D-lactate dehydrogenase, NAD-dependent 1781248 ldhA 7149784 ldhA Escherichia coli IAI39 fermentative D-lactate dehydrogenase, NAD-dependent YP_002407703.1 1780259 R 585057 CDS YP_002407704.1 218700075 7151919 1781456..1784095 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1784095 ydbH 7151919 ydbH Escherichia coli IAI39 hypothetical protein YP_002407704.1 1781456 D 585057 CDS YP_002407705.1 218700076 7153521 1784092..1784277 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein 1784277 ynbE 7153521 ynbE Escherichia coli IAI39 putative lipoprotein YP_002407705.1 1784092 D 585057 CDS YP_002407706.1 218700077 7154406 1784282..1784608 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1784608 ydbL 7154406 ydbL Escherichia coli IAI39 hypothetical protein YP_002407706.1 1784282 D 585057 CDS YP_002407707.1 218700078 7153524 1785061..1790940 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative cell adhesion autotransported outer membrane protein 1790940 ydbA 7153524 ydbA Escherichia coli IAI39 putative cell adhesion autotransported outer membrane protein YP_002407707.1 1785061 D 585057 CDS YP_002407708.1 218700079 7153518 1791148..1792008 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1792008 ydbC 7153518 ydbC Escherichia coli IAI39 putative oxidoreductase YP_002407708.1 1791148 D 585057 CDS YP_002407709.1 218700080 7153519 1792072..1794378 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1794378 ydbD 7153519 ydbD Escherichia coli IAI39 hypothetical protein YP_002407709.1 1792072 D 585057 CDS YP_002407710.1 218700081 7153520 1794542..1795153 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1795153 ynbA 7153520 ynbA Escherichia coli IAI39 hypothetical protein YP_002407710.1 1794542 D 585057 CDS YP_002407711.1 218700082 7154402 1795153..1796049 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane associated CTP-phosphosubstrate transferase 1796049 ynbB 7154402 ynbB Escherichia coli IAI39 putative membrane associated CTP-phosphosubstrate transferase YP_002407711.1 1795153 D 585057 CDS YP_002407712.1 218700083 7154403 1796065..1797831 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 1797831 ynbC 7154403 ynbC Escherichia coli IAI39 putative hydrolase YP_002407712.1 1796065 D 585057 CDS YP_002407713.1 218700084 7154404 1797845..1799137 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane associated phosphatase 1799137 ynbD 7154404 ynbD Escherichia coli IAI39 putative membrane associated phosphatase YP_002407713.1 1797845 D 585057 CDS YP_002407714.1 218700085 7154405 complement(1799191..1799796) 1 NC_011750.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase 1799796 azoR 7154405 azoR Escherichia coli IAI39 azoreductase YP_002407714.1 1799191 R 585057 CDS YP_002407715.1 218700086 7150831 1799895..1799969 1 NC_011750.1 hypothetical protein 1799969 7150831 ECIAI39_1717 Escherichia coli IAI39 hypothetical protein YP_002407715.1 1799895 D 585057 CDS YP_002407716.1 218700087 7149785 1800054..1803899 1 NC_011750.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1803899 hrpA 7149785 hrpA Escherichia coli IAI39 ATP-dependent RNA helicase HrpA YP_002407716.1 1800054 D 585057 CDS YP_002407717.1 218700088 7151673 1804268..1804972 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1804972 ydcF 7151673 ydcF Escherichia coli IAI39 hypothetical protein YP_002407717.1 1804268 D 585057 CDS YP_002407718.1 218700089 7150711 1806145..1806471 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 1806471 7150711 ECIAI39_1721 Escherichia coli IAI39 transposase ORF A, IS629 YP_002407718.1 1806145 D 585057 CDS YP_002407719.1 218700090 7149786 1806468..1807358 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 1807358 7149786 ECIAI39_1722 Escherichia coli IAI39 transposase ORF B, IS629 YP_002407719.1 1806468 D 585057 CDS YP_002407720.1 218700091 7149787 1807988..1808254 1 NC_011750.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 1808254 ydcE 7149787 ydcE Escherichia coli IAI39 4-oxalocrotonate tautomerase YP_002407720.1 1807988 D 585057 CDS YP_002407721.1 218700092 7153525 complement(1808258..1808827) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1808827 yddH 7153525 yddH Escherichia coli IAI39 hypothetical protein YP_002407721.1 1808258 R 585057 CDS YP_002407722.1 218700093 7153534 1809002..1809847 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20267568; Product type e : enzyme; N-hydroxyarylamine O-acetyltransferase 1809847 nhoA 7153534 nhoA Escherichia coli IAI39 N-hydroxyarylamine O-acetyltransferase YP_002407722.1 1809002 D 585057 CDS YP_002407723.1 218700094 7152223 complement(1809943..1810836) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14611652, 15103639, 2233673; hypothetical protein 1810836 yddE 7152223 yddE Escherichia coli IAI39 hypothetical protein YP_002407723.1 1809943 R 585057 CDS YP_002407724.1 218700095 7153532 complement(1810916..1811596) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type e : enzyme; nitrate reductase 2 (NRZ) subunit gamma 1811596 narV 7153532 narV Escherichia coli IAI39 nitrate reductase 2 (NRZ) subunit gamma YP_002407724.1 1810916 R 585057 CDS YP_002407725.1 218700096 7152197 complement(1811593..1812288) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410, 92186712; Product type f : factor; nitrate reductase 2 (NRZ) subunit delta 1812288 narW 7152197 narW Escherichia coli IAI39 nitrate reductase 2 (NRZ) subunit delta YP_002407725.1 1811593 R 585057 CDS YP_002407726.1 218700097 7152198 complement(1812288..1813832) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type c : carrier; nitrate reductase 2 (NRZ) subunit beta 1813832 narY 7152198 narY Escherichia coli IAI39 nitrate reductase 2 (NRZ) subunit beta YP_002407726.1 1812288 R 585057 CDS YP_002407727.1 218700098 7152200 complement(1813829..1817569) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type e : enzyme; nitrate reductase 2 (NRZ) subunit alpha 1817569 narZ 7152200 narZ Escherichia coli IAI39 nitrate reductase 2 (NRZ) subunit alpha YP_002407727.1 1813829 R 585057 CDS YP_002407728.1 218700099 7152201 complement(1817664..1819052) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95266795, 2233673; Product type t : transporter; nitrate/nitrite transporter 1819052 narU 7152201 narU Escherichia coli IAI39 nitrate/nitrite transporter YP_002407728.1 1817664 R 585057 CDS YP_002407729.1 218700100 7152196 complement(1819362..1820618) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1820618 7152196 ECIAI39_1732 Escherichia coli IAI39 hypothetical protein YP_002407729.1 1819362 R 585057 CDS YP_002407730.1 218700101 7149788 complement(1820681..1821946) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1821946 7149788 ECIAI39_1733 Escherichia coli IAI39 hypothetical protein YP_002407730.1 1820681 R 585057 CDS YP_002407731.1 218700102 7149789 complement(1822110..1823210) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type m : membrane component; outer membrane porin protein ompD 1823210 7149789 ECIAI39_1734 Escherichia coli IAI39 outer membrane porin protein ompD YP_002407731.1 1822110 R 585057 CDS YP_002407732.1 218700103 7149790 complement(1823468..1824292) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12410826; Product type t : transporter; hypothetical protein 1824292 yddG 7149790 yddG Escherichia coli IAI39 hypothetical protein YP_002407732.1 1823468 R 585057 CDS YP_002407733.1 218700104 7153533 1824581..1827628 1 NC_011750.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-N subunit alpha, nitrate-inducible 1827628 fdnG 7153533 fdnG Escherichia coli IAI39 formate dehydrogenase-N subunit alpha, nitrate-inducible YP_002407733.1 1824581 D 585057 CDS YP_002407734.1 218700105 7151286 1827641..1828525 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76005553, 90375017, 92332427, 11884747, 1834669; Product type c : carrier; formate dehydrogenase-N, Fe-S subunit beta, nitrate-inducible 1828525 fdnH 7151286 fdnH Escherichia coli IAI39 formate dehydrogenase-N, Fe-S subunit beta, nitrate-inducible YP_002407734.1 1827641 D 585057 CDS YP_002407735.1 218700106 7151287 1828518..1829171 1 NC_011750.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma 1829171 fdnI 7151287 fdnI Escherichia coli IAI39 formate dehydrogenase-N subunit gamma YP_002407735.1 1828518 D 585057 CDS YP_002407736.1 218700107 7153535 complement(1829506..1829784) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative plasmid maintenance system killer protein 1829784 7153535 ECIAI39_1741 Escherichia coli IAI39 putative plasmid maintenance system killer protein YP_002407736.1 1829506 R 585057 CDS YP_002407737.1 218700108 7149791 complement(1829970..1830980) 1 NC_011750.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 1830980 adhP 7149791 adhP Escherichia coli IAI39 alcohol dehydrogenase YP_002407737.1 1829970 R 585057 CDS YP_002407738.1 218700109 7150688 complement(1831114..1832811) 1 NC_011750.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 1832811 sfcA 7150688 sfcA Escherichia coli IAI39 malate dehydrogenase YP_002407738.1 1831114 R 585057 CDS YP_002407740.1 218700111 7149792 complement(1833207..1833422) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10498711, 13129944; Product type f : factor; biofilm-dependent modulation protein 1833422 bdm 7149792 bdm Escherichia coli IAI39 biofilm-dependent modulation protein YP_002407740.1 1833207 R 585057 CDS YP_002407741.1 218700112 7150851 1833767..1834198 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14512736, 91350191, 9298646; Product type m : membrane component; osmotically inducible, stress-inducible membrane protein 1834198 osmC 7150851 osmC Escherichia coli IAI39 osmotically inducible, stress-inducible membrane protein YP_002407741.1 1833767 D 585057 CDS YP_002407742.1 218700113 7152309 complement(1834254..1835180) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-ala ABC transporter ATP-binding protein 1835180 ddpF 7152309 ddpF Escherichia coli IAI39 D-ala-D-ala ABC transporter ATP-binding protein YP_002407742.1 1834254 R 585057 CDS YP_002407743.1 218700114 7151108 complement(1835173..1836159) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-ala ABC transporter ATP-binding protein 1836159 ddpD 7151108 ddpD Escherichia coli IAI39 D-ala-D-ala ABC transporter ATP-binding protein YP_002407743.1 1835173 R 585057 CDS YP_002407744.1 218700115 7151107 complement(1836156..1837052) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; ATP-dependent peptide transporter membrane subunit 1837052 ddpC 7151107 ddpC Escherichia coli IAI39 ATP-dependent peptide transporter membrane subunit YP_002407744.1 1836156 R 585057 CDS YP_002407745.1 218700116 7151106 complement(1837049..1838071) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-ala ABC transporter membrane protein 1838071 ddpB 7151106 ddpB Escherichia coli IAI39 D-ala-D-ala ABC transporter membrane protein YP_002407745.1 1837049 R 585057 CDS YP_002407746.1 218700117 7151105 complement(1838073..1839623) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-a la ABC transporter subunit periplasmic-binding protein 1839623 ddpA 7151105 ddpA Escherichia coli IAI39 D-ala-D-a la ABC transporter subunit periplasmic-binding protein YP_002407746.1 1838073 R 585057 CDS YP_002407747.1 218700118 7151104 complement(1839637..1840218) 1 NC_011750.1 catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis; D-alanyl-D-alanine dipeptidase 1840218 ddpX 7151104 ddpX Escherichia coli IAI39 D-alanyl-D-alanine dipeptidase YP_002407747.1 1839637 R 585057 CDS YP_002407748.1 218700119 7151165 complement(1842899..1844281) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16497924, 15142243; Product type pe : putative enzyme; putative diguanylate cyclase YddV 1844281 yddV 7151165 yddV Escherichia coli IAI39 putative diguanylate cyclase YddV YP_002407748.1 1842899 R 585057 CDS YP_002407749.1 218700120 7153536 complement(1844657..1845976) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10960106; Product type lp : lipoprotein; putative lipoprotein 1845976 yddW 7153536 yddW Escherichia coli IAI39 putative lipoprotein YP_002407749.1 1844657 R 585057 CDS YP_002407750.1 218700121 7153537 complement(1846107..1847642) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15795232, 15489450; Product type t : transporter; glutamate:gamma-aminobutyric acid antiporter 1847642 gadC 7153537 gadC Escherichia coli IAI39 glutamate:gamma-aminobutyric acid antiporter YP_002407750.1 1846107 R 585057 CDS YP_002407751.1 218700122 7151465 complement(1847798..1849198) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12912902, 92155241, 92394884, 99406302, 8455549; Product type e : enzyme; glutamate decarboxylase B, PLP-dependent 1849198 gadB 7151465 gadB Escherichia coli IAI39 glutamate decarboxylase B, PLP-dependent YP_002407751.1 1847798 R 585057 CDS YP_002407752.1 218700123 7151464 complement(1849561..1852356) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1659611, 11514505; Product type pe : putative enzyme; putative membrane-associated peptidase 1852356 pqqL 7151464 pqqL Escherichia coli IAI39 putative membrane-associated peptidase YP_002407752.1 1849561 R 585057 CDS YP_002407753.1 218700124 7152470 complement(1852401..1854773) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative porin protein 1854773 yddB 7152470 yddB Escherichia coli IAI39 putative porin protein YP_002407753.1 1852401 R 585057 CDS YP_002407754.1 218700125 7153531 complement(1854811..1856496) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative multidrug transporter fused subunits of ABC superfamily transporter: permease component; ATP-binding protein 1856496 yddA 7153531 yddA Escherichia coli IAI39 putative multidrug transporter fused subunits of ABC superfamily transporter: permease component; ATP-binding protein YP_002407754.1 1854811 R 585057 CDS YP_002407755.1 218700126 7153530 complement(1856788..1857945) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pr : putative regulator; hypothetical protein 1857945 ydeM 7153530 ydeM Escherichia coli IAI39 hypothetical protein YP_002407755.1 1856788 R 585057 CDS YP_002407756.1 218700127 7153543 complement(1857997..1859679) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sulfatase 1859679 ydeN 7153543 ydeN Escherichia coli IAI39 putative sulfatase YP_002407756.1 1857997 R 585057 CDS YP_002407757.1 218700128 7153544 complement(1860082..1860843) 1 NC_011750.1 regulates the cellular response to acid resistance; transcriptional regulator YdeO 1860843 ydeO 7153544 ydeO Escherichia coli IAI39 transcriptional regulator YdeO YP_002407757.1 1860082 R 585057 CDS YP_002407758.1 218700129 7153545 complement(1860918..1861115) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1861115 7153545 ECIAI39_1765 Escherichia coli IAI39 hypothetical protein YP_002407758.1 1860918 R 585057 CDS YP_002407759.1 218700130 7149793 complement(1861363..1863642) 1 NC_011750.1 in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase family; putative oxidoreductase 1863642 ydeP 7149793 ydeP Escherichia coli IAI39 putative oxidoreductase YP_002407759.1 1861363 R 585057 CDS YP_002407760.1 218700131 7153546 complement(1863981..1864895) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like exported adhesin protein 1864895 ydeQ 7153546 ydeQ Escherichia coli IAI39 putative fimbrial-like exported adhesin protein YP_002407760.1 1863981 R 585057 CDS YP_002407761.1 218700132 7153547 complement(1865216..1866106) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 1866106 7153547 ECIAI39_1768 Escherichia coli IAI39 transposase ORF B, IS629 YP_002407761.1 1865216 R 585057 CDS YP_002407762.1 218700133 7149794 complement(1866103..1866429) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 1866429 7149794 ECIAI39_1769 Escherichia coli IAI39 transposase ORF A, IS629 YP_002407762.1 1866103 R 585057 CDS YP_002407763.1 218700134 7153548 complement(1867416..1867508) 1 NC_011750.1 hypothetical protein 1867508 7153548 ECIAI39_1771 Escherichia coli IAI39 hypothetical protein YP_002407763.1 1867416 R 585057 CDS YP_002407764.1 218700135 7149796 1867420..1867830 1 NC_011750.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1867830 insC 7149796 insC Escherichia coli IAI39 insertion sequence 2 OrfA protein YP_002407764.1 1867420 D 585057 CDS YP_002407765.1 218700136 7151977 1871369..1872391 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11722742; Product type t : transporter; AI2 ABC transporter periplasmic-binding 1872391 lsrB 7151977 lsrB Escherichia coli IAI39 AI2 ABC transporter periplasmic-binding YP_002407765.1 1871369 D 585057 CDS YP_002407766.1 218700137 7151976 1872418..1873293 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; aldolase 1873293 lsrF 7151976 lsrF Escherichia coli IAI39 aldolase YP_002407766.1 1872418 D 585057 CDS YP_002407767.1 218700138 7151978 1873317..1873607 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; autoinducer-2 (AI-2) modifying protein LsrG 1873607 lsrG 7151978 lsrG Escherichia coli IAI39 autoinducer-2 (AI-2) modifying protein LsrG YP_002407767.1 1873317 D 585057 CDS YP_002407768.1 218700139 7151979 1873664..1874422 1 NC_011750.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 1874422 tam 7151979 tam Escherichia coli IAI39 trans-aconitate 2-methyltransferase YP_002407768.1 1873664 D 585057 CDS YP_002407769.1 218700140 7152940 complement(1874426..1875340) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1875340 yneE 7152940 yneE Escherichia coli IAI39 hypothetical protein YP_002407769.1 1874426 R 585057 CDS YP_002407770.1 218700141 7154408 1875290..1875454 1 NC_011750.1 hypothetical protein 1875454 7154408 ECIAI39_1784 Escherichia coli IAI39 hypothetical protein YP_002407770.1 1875290 D 585057 CDS YP_002407771.1 218700142 7149799 complement(1875537..1876988) 1 NC_011750.1 catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase 1876988 uxaB 7149799 uxaB Escherichia coli IAI39 altronate oxidoreductase YP_002407771.1 1875537 R 585057 CDS YP_002407772.1 218700143 7153119 complement(1877216..1878634) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated diguanylate cyclase (GGDEF domain) 1878634 yneF 7153119 yneF Escherichia coli IAI39 putative membrane-associated diguanylate cyclase (GGDEF domain) YP_002407772.1 1877216 R 585057 CDS YP_002407773.1 218700144 7154409 complement(1878773..1879132) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1879132 yneG 7154409 yneG Escherichia coli IAI39 hypothetical protein YP_002407773.1 1878773 R 585057 CDS YP_002407774.1 218700145 7154410 complement(1879132..1880058) 1 NC_011750.1 catalyzes the formation of glutamate from glutamine; glutaminase 1880058 yneH 7154410 yneH Escherichia coli IAI39 glutaminase YP_002407774.1 1879132 R 585057 CDS YP_002407775.1 218700146 7154411 complement(1880122..1881510) 1 NC_011750.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; putative succinate semialdehyde dehydrogenase 1881510 yneI 7154411 yneI Escherichia coli IAI39 putative succinate semialdehyde dehydrogenase YP_002407775.1 1880122 R 585057 CDS YP_002407776.1 218700147 7154413 complement(1882552..1883652) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; late control gene D protein 1883652 D 7154413 D Escherichia coli IAI39 late control gene D protein YP_002407776.1 1882552 R 585057 CDS YP_002407777.1 218700148 7151075 complement(1883649..1884134) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; bacteriophage tail protein GpU 1884134 U 7151075 U Escherichia coli IAI39 bacteriophage tail protein GpU YP_002407777.1 1883649 R 585057 CDS YP_002407778.1 218700149 7153067 complement(1884131..1887208) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail tape measure protein 1887208 7153067 ECIAI39_1793 Escherichia coli IAI39 putative phage tail tape measure protein YP_002407778.1 1884131 R 585057 CDS YP_002407779.1 218700150 7149800 complement(1887335..1887637) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail protein E 1887637 7149800 ECIAI39_1794 Escherichia coli IAI39 putative phage tail protein E YP_002407779.1 1887335 R 585057 CDS YP_002407780.1 218700151 7149801 complement(1887692..1888207) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail sheath protein FII 1888207 fII 7149801 fII Escherichia coli IAI39 major tail sheath protein FII YP_002407780.1 1887692 R 585057 CDS YP_002407781.1 218700152 7151327 complement(1888217..1889389) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail sheath protein FI 1889389 fI 7151327 fI Escherichia coli IAI39 major tail sheath protein FI YP_002407781.1 1888217 R 585057 CDS YP_002407782.1 218700153 7151323 complement(1889603..1890325) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase, IS26 1890325 7151323 ECIAI39_1797 Escherichia coli IAI39 transposase, IS26 YP_002407782.1 1889603 R 585057 CDS YP_002407783.1 218700154 7149803 complement(1891516..1892121) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail protein I (GpI) 1892121 I 7149803 I Escherichia coli IAI39 tail protein I (GpI) YP_002407783.1 1891516 R 585057 CDS YP_002407784.1 218700155 7151740 complement(1892114..1893061) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpJ 1893061 J 7151740 J Escherichia coli IAI39 Baseplate assembly protein GpJ YP_002407784.1 1892114 R 585057 CDS YP_002407785.1 218700156 7151869 complement(1893009..1893368) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpW 1893368 W 7151869 W Escherichia coli IAI39 Baseplate assembly protein GpW YP_002407785.1 1893009 R 585057 CDS YP_002407786.1 218700157 7153133 complement(1893365..1893943) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpV 1893943 V 7153133 V Escherichia coli IAI39 Baseplate assembly protein GpV YP_002407786.1 1893365 R 585057 CDS YP_002407787.1 218700158 7153124 complement(1894012..1894458) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail completion protein 1894458 7153124 ECIAI39_1803 Escherichia coli IAI39 putative phage tail completion protein YP_002407787.1 1894012 R 585057 CDS YP_002407788.1 218700159 7149804 complement(1894451..1894903) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail completion protein R (GpR) 1894903 R 7149804 R Escherichia coli IAI39 tail completion protein R (GpR) YP_002407788.1 1894451 R 585057 CDS YP_002407789.1 218700160 7152563 complement(1894845..1895135) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1895135 7152563 ECIAI39_1805 Escherichia coli IAI39 hypothetical protein YP_002407789.1 1894845 R 585057 CDS YP_002407790.1 218700161 7149805 complement(1894978..1895406) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative regulatory protein 1895406 7149805 ECIAI39_1806 Escherichia coli IAI39 putative regulatory protein YP_002407790.1 1894978 R 585057 CDS YP_002407791.1 218700162 7149806 complement(1895403..1895852) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1895852 7149806 ECIAI39_1807 Escherichia coli IAI39 hypothetical protein YP_002407791.1 1895403 R 585057 CDS YP_002407792.1 218700163 7149807 complement(1895782..1896294) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; putative lysozyme protein R of prophage 1896294 R 7149807 R Escherichia coli IAI39 putative lysozyme protein R of prophage YP_002407792.1 1895782 R 585057 CDS YP_002407793.1 218700164 7152564 complement(1896275..1896490) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative secretory protein 1896490 7152564 ECIAI39_1809 Escherichia coli IAI39 putative secretory protein YP_002407793.1 1896275 R 585057 CDS YP_002407794.1 218700165 7149808 complement(1896494..1896697) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage tail protein X (GpX) 1896697 X 7149808 X Escherichia coli IAI39 phage tail protein X (GpX) YP_002407794.1 1896494 R 585057 CDS YP_002407795.1 218700166 7153171 complement(1896697..1897224) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head completion/stabilization protein (GpL) 1897224 L 7153171 L Escherichia coli IAI39 head completion/stabilization protein (GpL) YP_002407795.1 1896697 R 585057 CDS YP_002407796.1 218700167 7151911 complement(1897257..1897907) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; terminase, endonuclease subunit (GpM) 1897907 M 7151911 M Escherichia coli IAI39 terminase, endonuclease subunit (GpM) YP_002407796.1 1897257 R 585057 CDS YP_002407797.1 218700168 7151989 complement(1897911..1898969) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor capsid protein H1 and H2, major capsid protein N* 1898969 N 7151989 N Escherichia coli IAI39 minor capsid protein H1 and H2, major capsid protein N* YP_002407797.1 1897911 R 585057 CDS YP_002407798.1 218700169 7152163 complement(1898986..1899819) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; putative capsid scaffolding protein GpO 1899819 O 7152163 O Escherichia coli IAI39 putative capsid scaffolding protein GpO YP_002407798.1 1898986 R 585057 CDS YP_002407799.1 218700170 7152317 1901114..1901836 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase, IS26 1901836 7152317 ECIAI39_1816 Escherichia coli IAI39 transposase, IS26 YP_002407799.1 1901114 D 585057 CDS YP_002407800.1 218700171 7152318 1902553..1903590 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage portal protein 1903590 7152318 ECIAI39_1818 Escherichia coli IAI39 putative phage portal protein YP_002407800.1 1902553 D 585057 CDS YP_002407801.1 218700172 7149810 1903720..1904046 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 1904046 7149810 ECIAI39_1819 Escherichia coli IAI39 transposase ORF A, IS629 YP_002407801.1 1903720 D 585057 CDS YP_002407802.1 218700173 7149811 1904043..1904933 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 1904933 7149811 ECIAI39_1820 Escherichia coli IAI39 transposase ORF B, IS629 YP_002407802.1 1904043 D 585057 CDS YP_002407803.1 218700174 7154414 1905868..1906983 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1906983 yneK 7154414 yneK Escherichia coli IAI39 hypothetical protein YP_002407803.1 1905868 D 585057 CDS YP_002407804.1 218700175 7154415 1907133..1908323 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10094697, 99369894, 8383113, 10438792; Product type t : transporter; sugar efflux transporter 1908323 ydeA 7154415 ydeA Escherichia coli IAI39 sugar efflux transporter YP_002407804.1 1907133 D 585057 CDS YP_002407805.1 218700176 7153538 complement(1908348..1909013) 1 NC_011750.1 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC 1909013 marC 7153538 marC Escherichia coli IAI39 multiple drug resistance protein MarC YP_002407805.1 1908348 R 585057 CDS YP_002407806.1 218700177 7152016 1909225..1909659 1 NC_011750.1 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; DNA-binding transcriptional repressor MarR 1909659 marR 7152016 marR Escherichia coli IAI39 DNA-binding transcriptional repressor MarR YP_002407806.1 1909225 D 585057 CDS YP_002407807.1 218700178 7152017 1909680..1910063 1 NC_011750.1 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; DNA-binding transcriptional activator MarA 1910063 marA 7152017 marA Escherichia coli IAI39 DNA-binding transcriptional activator MarA YP_002407807.1 1909680 D 585057 CDS YP_002407808.1 218700179 7152014 1910095..1910313 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8383113; hypothetical protein 1910313 marB 7152014 marB Escherichia coli IAI39 hypothetical protein YP_002407808.1 1910095 D 585057 CDS YP_002407809.1 218700180 7152015 complement(1910370..1911815) 1 NC_011750.1 converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase 1911815 celA 7152015 celA Escherichia coli IAI39 6-phospho-beta-glucosidase YP_002407809.1 1910370 R 585057 CDS YP_002407810.1 218700181 7149814 complement(1911834..1913507) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative carbohydrate-specific outer membrane porin 1913507 7149814 ECIAI39_1830 Escherichia coli IAI39 putative carbohydrate-specific outer membrane porin YP_002407810.1 1911834 R 585057 CDS YP_002407811.1 218700182 7149815 complement(1913563..1913880) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system PTS, lactose/cellobiose-specific IIA subunit 1913880 7149815 ECIAI39_1831 Escherichia coli IAI39 putative phosphotransferase system PTS, lactose/cellobiose-specific IIA subunit YP_002407811.1 1913563 R 585057 CDS YP_002407812.1 218700183 7149816 complement(1913902..1915224) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system IIC component 1915224 7149816 ECIAI39_1832 Escherichia coli IAI39 putative phosphotransferase system IIC component YP_002407812.1 1913902 R 585057 CDS YP_002407813.1 218700184 7149817 complement(1915338..1915649) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cellobiose-specific phosphotransferase enzyme IIB component 1915649 7149817 ECIAI39_1833 Escherichia coli IAI39 putative cellobiose-specific phosphotransferase enzyme IIB component YP_002407813.1 1915338 R 585057 CDS YP_002407814.1 218700185 7149818 1915848..1916546 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator HTH family 1916546 7149818 ECIAI39_1834 Escherichia coli IAI39 putative DNA-binding transcriptional regulator HTH family YP_002407814.1 1915848 D 585057 CDS YP_002407815.1 218700186 7149819 complement(1916591..1917490) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20305052; Product type t : transporter; O-acetylserine/cysteine export protein 1917490 eamA 7149819 eamA Escherichia coli IAI39 O-acetylserine/cysteine export protein YP_002407815.1 1916591 R 585057 CDS YP_002407816.1 218700187 7151194 1917685..1918872 1 NC_011750.1 YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters; putative MFS-type transporter YdeE 1918872 ydeE 7151194 ydeE Escherichia coli IAI39 putative MFS-type transporter YdeE YP_002407816.1 1917685 D 585057 CDS YP_002407817.1 218700188 7153539 complement(1918904..1919302) 1 NC_011750.1 hypothetical protein 1919302 7153539 ECIAI39_1837 Escherichia coli IAI39 hypothetical protein YP_002407817.1 1918904 R 585057 CDS YP_002407818.1 218700189 7149820 1919355..1920368 1 NC_011750.1 upregulated by FixLJ/FixK under oxygen limitation; involved in regulation of genes involved in carbon and amino acid metabolism; transcriptional activator FtrA 1920368 ftrA 7149820 ftrA Escherichia coli IAI39 transcriptional activator FtrA YP_002407818.1 1919355 D 585057 CDS YP_002407819.1 218700190 7149821 complement(1920790..1921680) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1921680 ydeH 7149821 ydeH Escherichia coli IAI39 hypothetical protein YP_002407819.1 1920790 R 585057 CDS YP_002407820.1 218700191 7153540 complement(1921935..1922327) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1922327 ydeI 7153540 ydeI Escherichia coli IAI39 hypothetical protein YP_002407820.1 1921935 R 585057 CDS YP_002407821.1 218700192 7153541 complement(1922693..1924738) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 216006, 8226676; Product type e : enzyme; dipeptidyl carboxypeptidase II 1924738 dcp 7153541 dcp Escherichia coli IAI39 dipeptidyl carboxypeptidase II YP_002407821.1 1922693 R 585057 CDS YP_002407822.1 218700193 7151092 1924875..1925621 1 NC_011750.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase 1925621 ydfG 7151092 ydfG Escherichia coli IAI39 3-hydroxy acid dehydrogenase YP_002407822.1 1924875 D 585057 CDS YP_002407823.1 218700194 7153549 1925710..1926396 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1926396 ydfH 7153549 ydfH Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002407823.1 1925710 D 585057 CDS YP_002407824.1 218700195 7153550 1926574..1926777 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12084818; Product type pc : putative carrier; putative selenium carrying protein 1926777 ydfZ 7153550 ydfZ Escherichia coli IAI39 putative selenium carrying protein YP_002407824.1 1926574 D 585057 CDS YP_002407825.1 218700196 7153561 complement(1926813..1928273) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative mannonate dehydrogenase 1928273 ydfI 7153561 ydfI Escherichia coli IAI39 putative mannonate dehydrogenase YP_002407825.1 1926813 R 585057 CDS YP_002407826.1 218700197 7153551 complement(1928363..1929646) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 1929646 ydfJ 7153551 ydfJ Escherichia coli IAI39 putative transporter YP_002407826.1 1928363 R 585057 CDS YP_002407827.1 218700198 7153552 1930399..1930665 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative DNA-binding transcriptional regulator; Qin prophage 1930665 ydfK 7153552 ydfK Escherichia coli IAI39 putative DNA-binding transcriptional regulator; Qin prophage YP_002407827.1 1930399 D 585057 CDS YP_002407828.1 218700199 7152422 complement(1931384..1932274) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 1932274 7152422 ECIAI39_1849 Escherichia coli IAI39 transposase ORF B, IS629 YP_002407828.1 1931384 R 585057 CDS YP_002407829.1 218700200 7149822 complement(1932271..1932597) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 1932597 7149822 ECIAI39_1850 Escherichia coli IAI39 transposase ORF A, IS629 YP_002407829.1 1932271 R 585057 CDS YP_002407830.1 218700201 7149823 complement(1932603..1933256) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1933256 7149823 ECIAI39_1851 Escherichia coli IAI39 hypothetical protein YP_002407830.1 1932603 R 585057 CDS YP_002407831.1 218700202 7149824 complement(1933266..1933547) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1933547 7149824 ECIAI39_1852 Escherichia coli IAI39 hypothetical protein YP_002407831.1 1933266 R 585057 CDS YP_002407832.1 218700203 7149825 complement(1933544..1935949) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative prophage side tail fiber protein 1935949 7149825 ECIAI39_1853 Escherichia coli IAI39 putative prophage side tail fiber protein YP_002407832.1 1933544 R 585057 CDS YP_002407833.1 218700204 7149826 complement(1936008..1936607) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Lom-like outer membrane protein of prophage 1936607 7149826 ECIAI39_1854 Escherichia coli IAI39 putative Lom-like outer membrane protein of prophage YP_002407833.1 1936008 R 585057 CDS YP_002407834.1 218700205 7149827 complement(1936675..1940475) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J 1940475 7149827 ECIAI39_1855 Escherichia coli IAI39 Host specificity protein J YP_002407834.1 1936675 R 585057 CDS YP_002407835.1 218700206 7149828 complement(1940819..1941499) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein I 1941499 7149828 ECIAI39_1856 Escherichia coli IAI39 tail assembly protein I YP_002407835.1 1940819 R 585057 CDS YP_002407836.1 218700207 7149829 complement(1941397..1942140) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein K 1942140 K 7149829 K Escherichia coli IAI39 tail assembly protein K YP_002407836.1 1941397 R 585057 CDS YP_002407837.1 218700208 7151870 complement(1942146..1942844) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein L 1942844 7151870 ECIAI39_1858 Escherichia coli IAI39 minor tail protein L YP_002407837.1 1942146 R 585057 CDS YP_002407838.1 218700209 7149830 complement(1942844..1943173) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein M 1943173 7149830 ECIAI39_1859 Escherichia coli IAI39 minor tail protein M YP_002407838.1 1942844 R 585057 CDS YP_002407839.1 218700210 7149831 complement(1943170..1945731) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein H 1945731 7149831 ECIAI39_1860 Escherichia coli IAI39 minor tail protein H YP_002407839.1 1943170 R 585057 CDS YP_002407840.1 218700211 7149832 complement(1945712..1946125) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein T 1946125 7149832 ECIAI39_1861 Escherichia coli IAI39 minor tail protein T YP_002407840.1 1945712 R 585057 CDS YP_002407841.1 218700212 7149833 complement(1946152..1946583) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein G 1946583 7149833 ECIAI39_1862 Escherichia coli IAI39 minor tail protein G YP_002407841.1 1946152 R 585057 CDS YP_002407842.1 218700213 7149834 complement(1946602..1947348) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail protein V 1947348 7149834 ECIAI39_1863 Escherichia coli IAI39 major tail protein V YP_002407842.1 1946602 R 585057 CDS YP_002407843.1 218700214 7149835 complement(1947356..1947751) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein U 1947751 7149835 ECIAI39_1864 Escherichia coli IAI39 minor tail protein U YP_002407843.1 1947356 R 585057 CDS YP_002407844.1 218700215 7149836 complement(1947748..1948281) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein Z (GpZ) 1948281 7149836 ECIAI39_1865 Escherichia coli IAI39 minor tail protein Z (GpZ) YP_002407844.1 1947748 R 585057 CDS YP_002407845.1 218700216 7149837 complement(1948297..1948650) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail attachment protein 1948650 7149837 ECIAI39_1866 Escherichia coli IAI39 tail attachment protein YP_002407845.1 1948297 R 585057 CDS YP_002407846.1 218700217 7149838 complement(1948643..1949074) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1949074 7149838 ECIAI39_1867 Escherichia coli IAI39 hypothetical protein YP_002407846.1 1948643 R 585057 CDS YP_002407847.1 218700218 7149839 complement(1949078..1950106) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major head protein 1950106 7149839 ECIAI39_1868 Escherichia coli IAI39 major head protein YP_002407847.1 1949078 R 585057 CDS YP_002407848.1 218700219 7149840 complement(1950164..1950511) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head decoration protein (gpD) (major capsid protein D) 1950511 7149840 ECIAI39_1869 Escherichia coli IAI39 head decoration protein (gpD) (major capsid protein D) YP_002407848.1 1950164 R 585057 CDS YP_002407849.1 218700220 7149841 complement(1950548..1952053) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head-tail preconnector protein GP5 1952053 7149841 ECIAI39_1870 Escherichia coli IAI39 head-tail preconnector protein GP5 YP_002407849.1 1950548 R 585057 CDS YP_002407850.1 218700221 7149842 complement(1952043..1953635) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head protein Gp4 1953635 7149842 ECIAI39_1871 Escherichia coli IAI39 head protein Gp4 YP_002407850.1 1952043 R 585057 CDS YP_002407851.1 218700222 7149843 complement(1953632..1953838) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head stabilization protein (head protein GP3) 1953838 7149843 ECIAI39_1872 Escherichia coli IAI39 head stabilization protein (head protein GP3) YP_002407851.1 1953632 R 585057 CDS YP_002407852.1 218700223 7149844 complement(1953822..1955750) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; terminase large subunit (Gp2) 1955750 7149844 ECIAI39_1873 Escherichia coli IAI39 terminase large subunit (Gp2) YP_002407852.1 1953822 R 585057 CDS YP_002407853.1 218700224 7149845 complement(1955722..1956231) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative terminase small subunit (DNA packaging protein Nu1) from bacteriophage origin 1956231 7149845 ECIAI39_1874 Escherichia coli IAI39 putative terminase small subunit (DNA packaging protein Nu1) from bacteriophage origin YP_002407853.1 1955722 R 585057 CDS YP_002407854.1 218700225 7149846 1956561..1956887 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 1956887 7149846 ECIAI39_1875 Escherichia coli IAI39 transposase ORF A, IS629 YP_002407854.1 1956561 D 585057 CDS YP_002407855.1 218700226 7149847 1956884..1957366 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 1957366 7149847 ECIAI39_1876 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002407855.1 1956884 D 585057 CDS YP_002407856.1 218700227 7149848 1957958..1959481 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative reverse transcriptase-like protein from putative prophage or plasmid 1959481 7149848 ECIAI39_1877 Escherichia coli IAI39 putative reverse transcriptase-like protein from putative prophage or plasmid YP_002407856.1 1957958 D 585057 CDS YP_002407857.1 218700228 7150534 1959658..1960044 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 1960044 7150534 ECIAI39_1878 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002407857.1 1959658 D 585057 CDS YP_002407858.1 218700229 7149851 complement(1960855..1961925) 1 NC_011750.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA; alanine racemase 1961925 dadX 7149851 dadX Escherichia coli IAI39 alanine racemase YP_002407858.1 1960855 R 585057 CDS YP_002407859.1 218700230 7151081 complement(1961935..1963233) 1 NC_011750.1 catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1963233 dadA 7151081 dadA Escherichia coli IAI39 D-amino acid dehydrogenase small subunit YP_002407859.1 1961935 R 585057 CDS YP_002407860.1 218700231 7151080 1963563..1965095 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; SpoVR family protein 1965095 ycgB 7151080 ycgB Escherichia coli IAI39 SpoVR family protein YP_002407860.1 1963563 D 585057 CDS YP_002407861.1 218700232 7153462 complement(1965147..1965866) 1 NC_011750.1 Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1965866 fadR 7153462 fadR Escherichia coli IAI39 fatty acid metabolism regulator YP_002407861.1 1965147 R 585057 CDS YP_002407862.1 218700233 7151278 1966089..1967630 1 NC_011750.1 involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter 1967630 nhaB 7151278 nhaB Escherichia coli IAI39 sodium/proton antiporter YP_002407862.1 1966089 D 585057 CDS YP_002407863.1 218700234 7152221 1967776..1968306 1 NC_011750.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 1968306 dsbB 7152221 dsbB Escherichia coli IAI39 disulfide bond formation protein B YP_002407863.1 1967776 D 585057 CDS YP_002407864.1 218700235 7151173 complement(1968352..1969620) 1 NC_011750.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1969620 umuC 7151173 umuC Escherichia coli IAI39 DNA polymerase V subunit UmuC YP_002407864.1 1968352 R 585057 CDS YP_002407865.1 218700236 7153102 complement(1969620..1970039) 1 NC_011750.1 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1970039 umuD 7153102 umuD Escherichia coli IAI39 DNA polymerase V subunit UmuD YP_002407865.1 1969620 R 585057 CDS YP_002407866.1 218700237 7153103 1970283..1970690 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1970690 7153103 ECIAI39_1889 Escherichia coli IAI39 hypothetical protein YP_002407866.1 1970283 D 585057 CDS YP_002407867.1 218700238 7149852 1970709..1971929 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase 1971929 7149852 ECIAI39_1890 Escherichia coli IAI39 putative transposase YP_002407867.1 1970709 D 585057 CDS YP_002407868.1 218700239 7150885 1972304..1973215 1 NC_011750.1 Acts by forming a pore-like structure upon contact with mammalian cells; hemolysin E 1973215 hlyE 7150885 hlyE Escherichia coli IAI39 hemolysin E YP_002407868.1 1972304 D 585057 CDS YP_002407869.1 218700240 7151661 complement(1973422..1973868) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1973868 ycgN 7151661 ycgN Escherichia coli IAI39 hypothetical protein YP_002407869.1 1973422 R 585057 CDS YP_002407870.1 218700241 7153470 complement(1973960..1974619) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15551868; Product type pe : putative enzyme; hypothetical protein 1974619 ycgM 7153470 ycgM Escherichia coli IAI39 hypothetical protein YP_002407870.1 1973960 R 585057 CDS YP_002407871.1 218700242 7153469 complement(1974691..1975017) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1975017 ycgL 7153469 ycgL Escherichia coli IAI39 hypothetical protein YP_002407871.1 1974691 R 585057 CDS YP_002407872.1 218700243 7153468 1975225..1975626 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1975626 ycgK 7153468 ycgK Escherichia coli IAI39 hypothetical protein YP_002407872.1 1975225 D 585057 CDS YP_002407873.1 218700244 7153467 complement(1975746..1976114) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1976114 ycgJ 7153467 ycgJ Escherichia coli IAI39 hypothetical protein YP_002407873.1 1975746 R 585057 CDS YP_002407874.1 218700245 7153466 1976634..1977329 1 NC_011750.1 blocks the formation of polar Z-ring septums; septum formation inhibitor 1977329 minC 7153466 minC Escherichia coli IAI39 septum formation inhibitor YP_002407874.1 1976634 D 585057 CDS YP_002407875.1 218700246 7152083 1977353..1978165 1 NC_011750.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD 1978165 minD 7152083 minD Escherichia coli IAI39 cell division inhibitor MinD YP_002407875.1 1977353 D 585057 CDS YP_002407876.1 218700247 7152084 1978169..1978435 1 NC_011750.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 1978435 minE 7152084 minE Escherichia coli IAI39 cell division topological specificity factor MinE YP_002407876.1 1978169 D 585057 CDS YP_002407877.1 218700248 7152085 complement(1978801..1979244) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1979244 7152085 ECIAI39_1900 Escherichia coli IAI39 hypothetical protein YP_002407877.1 1978801 R 585057 CDS YP_002407878.1 218700249 7149854 1979546..1979719 1 NC_011750.1 hypothetical protein 1979719 7149854 ECIAI39_1901 Escherichia coli IAI39 hypothetical protein YP_002407878.1 1979546 D 585057 CDS YP_002407879.1 218700250 7149855 1979790..1980065 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1980065 ymgG 7149855 ymgG Escherichia coli IAI39 hypothetical protein YP_002407879.1 1979790 D 585057 CDS YP_002407880.1 218700251 7154398 1980075..1980404 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1980404 ymgD 7154398 ymgD Escherichia coli IAI39 hypothetical protein YP_002407880.1 1980075 D 585057 CDS YP_002407881.1 218700252 7154396 complement(1980462..1983110) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane autotransporter barrel, putative pectin lyase fold 1983110 7154396 ECIAI39_1904 Escherichia coli IAI39 putative outer membrane autotransporter barrel, putative pectin lyase fold YP_002407881.1 1980462 R 585057 CDS YP_002407882.1 218700253 7149856 complement(1983860..1985383) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1985383 ycgG 7149856 ycgG Escherichia coli IAI39 hypothetical protein YP_002407882.1 1983860 R 585057 CDS YP_002407883.1 218700254 7153465 1985791..1986117 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 1986117 7153465 ECIAI39_1907 Escherichia coli IAI39 transposase ORF A, IS629 YP_002407883.1 1985791 D 585057 CDS YP_002407884.1 218700255 7149857 1986114..1987004 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 1987004 7149857 ECIAI39_1908 Escherichia coli IAI39 transposase ORF B, IS629 YP_002407884.1 1986114 D 585057 CDS YP_002407885.1 218700256 7149858 complement(1987044..1987280) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1987280 ymgC 7149858 ymgC Escherichia coli IAI39 hypothetical protein YP_002407885.1 1987044 R 585057 CDS YP_002407886.1 218700257 7154395 complement(1987393..1987659) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1987659 ymgB 7154395 ymgB Escherichia coli IAI39 hypothetical protein YP_002407886.1 1987393 R 585057 CDS YP_002407887.1 218700258 7154394 complement(1987688..1987960) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1987960 ymgA 7154394 ymgA Escherichia coli IAI39 hypothetical protein YP_002407887.1 1987688 R 585057 CDS YP_002407888.1 218700259 7154393 complement(1988003..1988239) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1988239 ycgZ 7154393 ycgZ Escherichia coli IAI39 hypothetical protein YP_002407888.1 1988003 R 585057 CDS YP_002407889.1 218700260 7153473 1988553..1989764 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16533062, 15453820; Product type pe : putative enzyme; putative blue-light sensing cyclic-di-GMP phosphodiesterase 1989764 ycgF 7153473 ycgF Escherichia coli IAI39 putative blue-light sensing cyclic-di-GMP phosphodiesterase YP_002407889.1 1988553 D 585057 CDS YP_002407890.1 218700261 7153464 1989969..1990700 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1990700 ycgE 7153464 ycgE Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002407890.1 1989969 D 585057 CDS YP_002407891.1 218700262 7153463 1990921..1991325 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1991325 ycgX 7153463 ycgX Escherichia coli IAI39 hypothetical protein YP_002407891.1 1990921 D 585057 CDS YP_002407892.1 218700263 7153472 1992030..1992353 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9603997; hypothetical protein 1992353 elbA 7153472 elbA Escherichia coli IAI39 hypothetical protein YP_002407892.1 1992030 D 585057 CDS YP_002407893.1 218700264 7151750 complement(1993080..1993850) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1993850 7151750 ECIAI39_1918 Escherichia coli IAI39 hypothetical protein YP_002407893.1 1993080 R 585057 CDS YP_002407894.1 218700265 7149859 1994537..1995451 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12654809, 10085045; Product type t : transporter; iron transport protein, periplasmic-binding protein 1995451 sitA 7149859 sitA Escherichia coli IAI39 iron transport protein, periplasmic-binding protein YP_002407894.1 1994537 D 585057 CDS YP_002407895.1 218700266 7152853 1995451..1996278 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12654809, 10085045; Product type m : membrane component; iron transport protein, ATP-binding protein 1996278 sitB 7152853 sitB Escherichia coli IAI39 iron transport protein, ATP-binding protein YP_002407895.1 1995451 D 585057 CDS YP_002407896.1 218700267 7152854 1996275..1997132 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12654809, 10085045; Product type m : membrane component; iron transporter inner membrane component 1997132 sitC 7152854 sitC Escherichia coli IAI39 iron transporter inner membrane component YP_002407896.1 1996275 D 585057 CDS YP_002407897.1 218700268 7152855 1997129..1997986 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12654809, 10085045; Product type m : membrane component; iron transporter inner membrane component 1997986 sitD 7152855 sitD Escherichia coli IAI39 iron transporter inner membrane component YP_002407897.1 1997129 D 585057 CDS YP_002407898.1 218700269 7152856 complement(1998078..1998371) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1998371 7152856 ECIAI39_1923 Escherichia coli IAI39 hypothetical protein YP_002407898.1 1998078 R 585057 CDS YP_002407899.1 218700270 7149860 complement(1998382..1999086) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1999086 7149860 ECIAI39_1924 Escherichia coli IAI39 hypothetical protein YP_002407899.1 1998382 R 585057 CDS YP_002407900.1 218700271 7149861 complement(1999096..1999377) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1999377 7149861 ECIAI39_1925 Escherichia coli IAI39 hypothetical protein YP_002407900.1 1999096 R 585057 CDS YP_002407901.1 218700272 7149862 complement(1999374..2001779) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative prophage side tail fiber protein 2001779 7149862 ECIAI39_1926 Escherichia coli IAI39 putative prophage side tail fiber protein YP_002407901.1 1999374 R 585057 CDS YP_002407902.1 218700273 7149864 complement(2002172..2002561) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA-binding protein from phage origin 2002561 7149864 ECIAI39_1928 Escherichia coli IAI39 putative DNA-binding protein from phage origin YP_002407902.1 2002172 R 585057 CDS YP_002407903.1 218700274 7149865 complement(2002533..2003024) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2003024 7149865 ECIAI39_1929 Escherichia coli IAI39 hypothetical protein YP_002407903.1 2002533 R 585057 CDS YP_002407904.1 218700275 7149866 complement(2003180..2003410) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2003410 7149866 ECIAI39_1930 Escherichia coli IAI39 hypothetical protein YP_002407904.1 2003180 R 585057 CDS YP_002407905.1 218700276 7149867 complement(2003407..2004126) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2004126 7149867 ECIAI39_1931 Escherichia coli IAI39 hypothetical protein YP_002407905.1 2003407 R 585057 CDS YP_002407906.1 218700277 7149868 complement(2004087..2004302) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2004302 7149868 ECIAI39_1932 Escherichia coli IAI39 hypothetical protein YP_002407906.1 2004087 R 585057 CDS YP_002407907.1 218700278 7149869 complement(2004317..2004613) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2004613 7149869 ECIAI39_1933 Escherichia coli IAI39 hypothetical protein YP_002407907.1 2004317 R 585057 CDS YP_002407908.1 218700279 7149870 complement(2004623..2004895) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2004895 7149870 ECIAI39_1934 Escherichia coli IAI39 hypothetical protein YP_002407908.1 2004623 R 585057 CDS YP_002407909.1 218700280 7149871 complement(2005184..2005714) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2945162; Product type h : extrachromosomal origin; Host-nuclease inhibitor protein from bacteriophage 2005714 gam 7149871 gam Escherichia coli IAI39 Host-nuclease inhibitor protein from bacteriophage YP_002407909.1 2005184 R 585057 CDS YP_002407910.1 218700281 7151479 complement(2006014..2007207) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2007207 7151479 ECIAI39_1936 Escherichia coli IAI39 hypothetical protein YP_002407910.1 2006014 R 585057 CDS YP_002407911.1 218700282 7149872 complement(2007191..2008960) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2008960 7149872 ECIAI39_1937 Escherichia coli IAI39 hypothetical protein YP_002407911.1 2007191 R 585057 CDS YP_002407912.1 218700283 7149873 complement(2008964..2009878) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2009878 7149873 ECIAI39_1938 Escherichia coli IAI39 hypothetical protein YP_002407912.1 2008964 R 585057 CDS YP_002407913.1 218700284 7149874 complement(2009889..2010197) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage-related DNA-binding protein 2010197 7149874 ECIAI39_1939 Escherichia coli IAI39 putative phage-related DNA-binding protein YP_002407913.1 2009889 R 585057 CDS YP_002407914.1 218700285 7149875 complement(2010250..2010438) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage-related DNA-binding protein 2010438 7149875 ECIAI39_1940 Escherichia coli IAI39 putative phage-related DNA-binding protein YP_002407914.1 2010250 R 585057 CDS YP_002407915.1 218700286 7149876 2010489..2010950 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA-binding protein from phage origin 2010950 7149876 ECIAI39_1941 Escherichia coli IAI39 putative DNA-binding protein from phage origin YP_002407915.1 2010489 D 585057 CDS YP_002407916.1 218700287 7149877 2010947..2011933 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2011933 7149877 ECIAI39_1942 Escherichia coli IAI39 hypothetical protein YP_002407916.1 2010947 D 585057 CDS YP_002407917.1 218700288 7149878 2012015..2012605 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 2012605 7149878 ECIAI39_1943 Escherichia coli IAI39 hypothetical protein YP_002407917.1 2012015 D 585057 CDS YP_002407918.1 218700289 7149879 complement(2012643..2013119) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATPase 2013119 7149879 ECIAI39_1944 Escherichia coli IAI39 putative ABC transporter ATPase YP_002407918.1 2012643 R 585057 CDS YP_002407919.1 218700290 7149880 2013202..2013600 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative phage-related membrane protein 2013600 7149880 ECIAI39_1945 Escherichia coli IAI39 putative phage-related membrane protein YP_002407919.1 2013202 D 585057 CDS YP_002407920.1 218700291 7149881 2013603..2014343 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phage-related lytic murein transglycosylase 2014343 7149881 ECIAI39_1946 Escherichia coli IAI39 putative phage-related lytic murein transglycosylase YP_002407920.1 2013603 D 585057 CDS YP_002407921.1 218700292 7149882 2014327..2014977 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative phage-related lipoprotein 2014977 7149882 ECIAI39_1947 Escherichia coli IAI39 putative phage-related lipoprotein YP_002407921.1 2014327 D 585057 CDS YP_002407922.1 218700293 7149883 2014974..2015300 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative membrane protein from phage origin 2015300 7149883 ECIAI39_1948 Escherichia coli IAI39 putative membrane protein from phage origin YP_002407922.1 2014974 D 585057 CDS YP_002407923.1 218700294 7149884 2015300..2015611 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2015611 7149884 ECIAI39_1949 Escherichia coli IAI39 hypothetical protein YP_002407923.1 2015300 D 585057 CDS YP_002407924.1 218700295 7149885 2015611..2016060 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2016060 7149885 ECIAI39_1950 Escherichia coli IAI39 hypothetical protein YP_002407924.1 2015611 D 585057 CDS YP_002407925.1 218700296 7149886 2016153..2017748 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage-related protein 2017748 7149886 ECIAI39_1951 Escherichia coli IAI39 putative phage-related protein YP_002407925.1 2016153 D 585057 CDS YP_002407926.1 218700297 7149887 2017748..2019244 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2019244 7149887 ECIAI39_1952 Escherichia coli IAI39 hypothetical protein YP_002407926.1 2017748 D 585057 CDS YP_002407927.1 218700298 7149888 2019225..2020046 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head morphogenesis protein of bacteriophage 2020046 7149888 ECIAI39_1953 Escherichia coli IAI39 putative head morphogenesis protein of bacteriophage YP_002407927.1 2019225 D 585057 CDS YP_002407928.1 218700299 7149889 2020049..2020507 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage virion morphogenesis protein 2020507 7149889 ECIAI39_1954 Escherichia coli IAI39 putative phage virion morphogenesis protein YP_002407928.1 2020049 D 585057 CDS YP_002407929.1 218700300 7149890 2020722..2021837 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2021837 7149890 ECIAI39_1955 Escherichia coli IAI39 hypothetical protein YP_002407929.1 2020722 D 585057 CDS YP_002407930.1 218700301 7149891 2021852..2022805 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2022805 7149891 ECIAI39_1956 Escherichia coli IAI39 hypothetical protein YP_002407930.1 2021852 D 585057 CDS YP_002407931.1 218700302 7149892 2022815..2023153 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2023153 7149892 ECIAI39_1957 Escherichia coli IAI39 hypothetical protein YP_002407931.1 2022815 D 585057 CDS YP_002407932.1 218700303 7149893 2023155..2023601 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2023601 7149893 ECIAI39_1958 Escherichia coli IAI39 hypothetical protein YP_002407932.1 2023155 D 585057 CDS YP_002407933.1 218700304 7149894 2023601..2024065 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2024065 7149894 ECIAI39_1959 Escherichia coli IAI39 hypothetical protein YP_002407933.1 2023601 D 585057 CDS YP_002407934.1 218700305 7149895 2024062..2024316 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2024316 7149895 ECIAI39_1960 Escherichia coli IAI39 hypothetical protein YP_002407934.1 2024062 D 585057 CDS YP_002407935.1 218700306 7149896 2024306..2025733 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail sheath protein 2025733 7149896 ECIAI39_1961 Escherichia coli IAI39 putative phage tail sheath protein YP_002407935.1 2024306 D 585057 CDS YP_002407936.1 218700307 7149897 2025733..2026254 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail core protein 2026254 7149897 ECIAI39_1962 Escherichia coli IAI39 putative phage tail core protein YP_002407936.1 2025733 D 585057 CDS YP_002407937.1 218700308 7149898 2026305..2026439 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2026439 7149898 ECIAI39_1963 Escherichia coli IAI39 hypothetical protein YP_002407937.1 2026305 D 585057 CDS YP_002407938.1 218700309 7149899 2026636..2026971 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2026971 7149899 ECIAI39_1964 Escherichia coli IAI39 hypothetical protein YP_002407938.1 2026636 D 585057 CDS YP_002407939.1 218700310 7149900 2027129..2030080 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage minor tail protein 2030080 7149900 ECIAI39_1965 Escherichia coli IAI39 putative phage minor tail protein YP_002407939.1 2027129 D 585057 CDS YP_002407940.1 218700311 7149901 2030080..2030964 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; hypothetical protein 2030964 7149901 ECIAI39_1966 Escherichia coli IAI39 hypothetical protein YP_002407940.1 2030080 D 585057 CDS YP_002407941.1 218700312 7149902 2030961..2031176 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail protein 2031176 7149902 ECIAI39_1967 Escherichia coli IAI39 putative phage tail protein YP_002407941.1 2030961 D 585057 CDS YP_002407942.1 218700313 7149903 2031164..2032318 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative control protein for phage late genes expression 2032318 7149903 ECIAI39_1968 Escherichia coli IAI39 putative control protein for phage late genes expression YP_002407942.1 2031164 D 585057 CDS YP_002407943.1 218700314 7149904 2032315..2032911 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage baseplate component 2032911 7149904 ECIAI39_1969 Escherichia coli IAI39 putative phage baseplate component YP_002407943.1 2032315 D 585057 CDS YP_002407944.1 218700315 7149906 2033304..2034407 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative bacteriophage baseplate assembly protein 2034407 7149906 ECIAI39_1971 Escherichia coli IAI39 putative bacteriophage baseplate assembly protein YP_002407944.1 2033304 D 585057 CDS YP_002407945.1 218700316 7149907 2034400..2034978 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail fiber protein 2034978 7149907 ECIAI39_1972 Escherichia coli IAI39 putative phage tail fiber protein YP_002407945.1 2034400 D 585057 CDS YP_002407946.1 218700317 7149908 2034981..2037041 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative side tail fiber protein from lambdoid prophage 2037041 7149908 ECIAI39_1973 Escherichia coli IAI39 putative side tail fiber protein from lambdoid prophage YP_002407946.1 2034981 D 585057 CDS YP_002407947.1 218700318 7149909 complement(2037048..2037662) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber chaperone (assembly protein) from lambdoid prophage 2037662 7149909 ECIAI39_1974 Escherichia coli IAI39 putative tail fiber chaperone (assembly protein) from lambdoid prophage YP_002407947.1 2037048 R 585057 CDS YP_002407948.1 218700319 7149911 2038246..2038818 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; DNA-invertase (site specific recombinase) from prophage 2038818 pin 7149911 pin Escherichia coli IAI39 DNA-invertase (site specific recombinase) from prophage YP_002407948.1 2038246 D 585057 CDS YP_002407949.1 218700320 7152420 complement(2038856..2039329) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Lom-like outer membrane protein of prophage 2039329 7152420 ECIAI39_1977 Escherichia coli IAI39 putative Lom-like outer membrane protein of prophage YP_002407949.1 2038856 R 585057 CDS YP_002407950.1 218700321 7149913 complement(2039567..2040115) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; terminase small subunit (Gp1) 2040115 7149913 ECIAI39_1979 Escherichia coli IAI39 terminase small subunit (Gp1) YP_002407950.1 2039567 R 585057 CDS YP_002407951.1 218700322 7149914 complement(2040197..2040451) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2040451 7149914 ECIAI39_1980 Escherichia coli IAI39 hypothetical protein YP_002407951.1 2040197 R 585057 CDS YP_002407952.1 218700323 7149915 2040313..2040516 1 NC_011750.1 hypothetical protein 2040516 7149915 ECIAI39_1981 Escherichia coli IAI39 hypothetical protein YP_002407952.1 2040313 D 585057 CDS YP_002407953.1 218700324 7149916 complement(2040678..2040860) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2040860 7149916 ECIAI39_1982 Escherichia coli IAI39 hypothetical protein YP_002407953.1 2040678 R 585057 CDS YP_002407954.1 218700325 7149917 complement(2041067..2041447) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tonB-like membrane protein encoded within prophage 2041447 7149917 ECIAI39_1983 Escherichia coli IAI39 putative tonB-like membrane protein encoded within prophage YP_002407954.1 2041067 R 585057 CDS YP_002407955.1 218700326 7150874 complement(2042038..2042928) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 2042928 7150874 ECIAI39_1985 Escherichia coli IAI39 transposase ORF B, IS629 YP_002407955.1 2042038 R 585057 CDS YP_002407956.1 218700327 7149919 complement(2042925..2043251) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 2043251 7149919 ECIAI39_1986 Escherichia coli IAI39 transposase ORF A, IS629 YP_002407956.1 2042925 R 585057 CDS YP_002407957.1 218700328 7149920 2043372..2043740 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative single-stranded DNA binding protein of prophage 2043740 7149920 ECIAI39_1987 Escherichia coli IAI39 putative single-stranded DNA binding protein of prophage YP_002407957.1 2043372 D 585057 CDS YP_002407958.1 218700329 7149921 2043820..2044089 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host killing protein from bacteriophage origin 2044089 kil 7149921 kil Escherichia coli IAI39 Host killing protein from bacteriophage origin YP_002407958.1 2043820 D 585057 CDS YP_002407959.1 218700330 7151899 2044165..2044461 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative host-nuclease inhibitor protein Gam of bacteriophage 2044461 7151899 ECIAI39_1989 Escherichia coli IAI39 putative host-nuclease inhibitor protein Gam of bacteriophage YP_002407959.1 2044165 D 585057 CDS YP_002407960.1 218700331 7149922 2044467..2045252 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 6458018, 6221115; Product type h : extrachromosomal origin; Recombination protein bet from phage origin 2045252 7149922 ECIAI39_1990 Escherichia coli IAI39 Recombination protein bet from phage origin YP_002407960.1 2044467 D 585057 CDS YP_002407961.1 218700332 7149923 2045249..2045929 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; exonuclease from phage origin 2045929 7149923 ECIAI39_1991 Escherichia coli IAI39 exonuclease from phage origin YP_002407961.1 2045249 D 585057 CDS YP_002407962.1 218700333 7149924 2046081..2046833 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2046833 7149924 ECIAI39_1992 Escherichia coli IAI39 hypothetical protein YP_002407962.1 2046081 D 585057 CDS YP_002407963.1 218700334 7149925 2046841..2047056 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2047056 7149925 ECIAI39_1993 Escherichia coli IAI39 hypothetical protein YP_002407963.1 2046841 D 585057 CDS YP_002407964.1 218700335 7149926 2047800..2048036 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative excisionase 2048036 ymfG 7149926 ymfG Escherichia coli IAI39 putative excisionase YP_002407964.1 2047800 D 585057 CDS YP_002407965.1 218700336 7154387 complement(2049282..2050532) 1 NC_011750.1 Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 2050532 icd 7154387 icd Escherichia coli IAI39 isocitrate dehydrogenase YP_002407965.1 2049282 R 585057 CDS YP_002407966.1 218700337 7151751 complement(2050866..2051159) 1 NC_011750.1 hypothetical protein 2051159 7151751 ECIAI39_1996 Escherichia coli IAI39 hypothetical protein YP_002407966.1 2050866 R 585057 CDS YP_002407967.1 218700338 7149927 2051112..2051510 1 NC_011750.1 hypothetical protein 2051510 7149927 ECIAI39_1997 Escherichia coli IAI39 hypothetical protein YP_002407967.1 2051112 D 585057 CDS YP_002407968.1 218700339 7149928 complement(2051513..2052403) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 2052403 7149928 ECIAI39_1998 Escherichia coli IAI39 transposase ORF B, IS629 YP_002407968.1 2051513 R 585057 CDS YP_002407969.1 218700340 7149929 complement(2052400..2052726) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 2052726 7149929 ECIAI39_1999 Escherichia coli IAI39 transposase ORF A, IS629 YP_002407969.1 2052400 R 585057 CDS YP_002407970.1 218700341 7149930 2052859..2053209 1 NC_011750.1 putative cytoplasmic protein 2053209 7149930 ECIAI39_2000 Escherichia coli IAI39 putative cytoplasmic protein YP_002407970.1 2052859 D 585057 CDS YP_002407971.1 218700342 7149931 2053530..2054180 1 NC_011750.1 catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E 2054180 ymfC 7149931 ymfC Escherichia coli IAI39 23S rRNA pseudouridine synthase E YP_002407971.1 2053530 D 585057 CDS YP_002407972.1 218700343 7154386 2054190..2054651 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217; Product type e : enzyme; bifunctional thiamin pyrimidine pyrophosphate hydrolase and thiamin pyrophosphate hydrolase 2054651 ymfB 7154386 ymfB Escherichia coli IAI39 bifunctional thiamin pyrimidine pyrophosphate hydrolase and thiamin pyrophosphate hydrolase YP_002407972.1 2054190 D 585057 CDS YP_002407973.1 218700344 7154385 2054705..2055811 1 NC_011750.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 2055811 mnmA 7154385 mnmA Escherichia coli IAI39 tRNA-specific 2-thiouridylase MnmA YP_002407973.1 2054705 D 585057 CDS YP_002407974.1 218700345 7153030 2055847..2056488 1 NC_011750.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 2056488 hflD 7153030 hflD Escherichia coli IAI39 hypothetical protein YP_002407974.1 2055847 D 585057 CDS YP_002407975.1 218700346 7151638 2056492..2057862 1 NC_011750.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 2057862 purB 7151638 purB Escherichia coli IAI39 adenylosuccinate lyase YP_002407975.1 2056492 D 585057 CDS YP_002407976.1 218700347 7152524 2058031..2058702 1 NC_011750.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP 2058702 phoP 7152524 phoP Escherichia coli IAI39 DNA-binding transcriptional regulator PhoP YP_002407976.1 2058031 D 585057 CDS YP_002407977.1 218700348 7152413 2058702..2060162 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92105017; Product type r : regulator; sensor protein PhoQ 2060162 phoQ 7152413 phoQ Escherichia coli IAI39 sensor protein PhoQ YP_002407977.1 2058702 D 585057 CDS YP_002407978.1 218700349 7152414 complement(2060694..2060975) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2060975 7152414 ECIAI39_2009 Escherichia coli IAI39 hypothetical protein YP_002407978.1 2060694 R 585057 CDS YP_002407979.1 218700350 7149932 complement(2060989..2062650) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage terminase large subunit 2062650 7149932 ECIAI39_2010 Escherichia coli IAI39 putative phage terminase large subunit YP_002407979.1 2060989 R 585057 CDS YP_002407980.1 218700351 7149933 complement(2062634..2062990) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage terminase, small subunit 2062990 7149933 ECIAI39_2011 Escherichia coli IAI39 putative phage terminase, small subunit YP_002407980.1 2062634 R 585057 CDS YP_002407981.1 218700352 7149934 complement(2063279..2063719) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; putative endonuclease 2063719 7149934 ECIAI39_2012 Escherichia coli IAI39 putative endonuclease YP_002407981.1 2063279 R 585057 CDS YP_002407982.1 218700353 7149935 complement(2063719..2064015) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2064015 7149935 ECIAI39_2013 Escherichia coli IAI39 hypothetical protein YP_002407982.1 2063719 R 585057 CDS YP_002407983.1 218700354 7149936 complement(2064012..2064350) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head-tail adaptor 2064350 7149936 ECIAI39_2014 Escherichia coli IAI39 putative head-tail adaptor YP_002407983.1 2064012 R 585057 CDS YP_002407984.1 218700355 7149937 complement(2064347..2065561) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head portal protein 2065561 7149937 ECIAI39_2015 Escherichia coli IAI39 putative head portal protein YP_002407984.1 2064347 R 585057 CDS YP_002407985.1 218700356 7149938 complement(2065563..2066138) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head maturation protease of prophage 2066138 7149938 ECIAI39_2016 Escherichia coli IAI39 putative head maturation protease of prophage YP_002407985.1 2065563 R 585057 CDS YP_002407986.1 218700357 7149939 complement(2066174..2067346) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative major capsid protein of prophage 2067346 7149939 ECIAI39_2017 Escherichia coli IAI39 putative major capsid protein of prophage YP_002407986.1 2066174 R 585057 CDS YP_002407987.1 218700358 7149940 complement(2067916..2068326) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative single stranded DNA-binding protein of prophage 2068326 7149940 ECIAI39_2018 Escherichia coli IAI39 putative single stranded DNA-binding protein of prophage YP_002407987.1 2067916 R 585057 CDS YP_002407988.1 218700359 7149941 complement(2068323..2068580) 1 NC_011750.1 hypothetical protein 2068580 7149941 ECIAI39_2019 Escherichia coli IAI39 hypothetical protein YP_002407988.1 2068323 R 585057 CDS YP_002407989.1 218700360 7149942 complement(2068869..2070617) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; nucleic acid independent nucleoside triphosphatase; phage DNA primase 2070617 7149942 ECIAI39_2020 Escherichia coli IAI39 nucleic acid independent nucleoside triphosphatase; phage DNA primase YP_002407989.1 2068869 R 585057 CDS YP_002407990.1 218700361 7149943 complement(2070614..2070913) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2070913 7149943 ECIAI39_2021 Escherichia coli IAI39 hypothetical protein YP_002407990.1 2070614 R 585057 CDS YP_002407991.1 218700362 7149944 complement(2071139..2071603) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2071603 7149944 ECIAI39_2023 Escherichia coli IAI39 hypothetical protein YP_002407991.1 2071139 R 585057 CDS YP_002407992.1 218700363 7150890 complement(2071596..2072657) 1 NC_011750.1 hypothetical protein 2072657 7150890 ECIAI39_2024 Escherichia coli IAI39 hypothetical protein YP_002407992.1 2071596 R 585057 CDS YP_002407993.1 218700364 7149946 complement(2072715..2072903) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage regulatory protein 2072903 7149946 ECIAI39_2026 Escherichia coli IAI39 putative phage regulatory protein YP_002407993.1 2072715 R 585057 CDS YP_002407994.1 218700365 7149947 complement(2073278..2074528) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; integrase of prophage 2074528 int 7149947 int Escherichia coli IAI39 integrase of prophage YP_002407994.1 2073278 R 585057 CDS YP_002407995.1 218700366 7151829 2074756..2075877 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2075877 ycfD 7151829 ycfD Escherichia coli IAI39 hypothetical protein YP_002407995.1 2074756 D 585057 CDS YP_002407996.1 218700367 7153449 complement(2076023..2077105) 1 NC_011750.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 2077105 pepT 7153449 pepT Escherichia coli IAI39 peptidase T YP_002407996.1 2076023 R 585057 CDS YP_002407997.1 218700368 7152368 2077162..2077488 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 2077488 7152368 ECIAI39_2030 Escherichia coli IAI39 transposase ORF A, IS629 YP_002407997.1 2077162 D 585057 CDS YP_002407998.1 218700369 7149948 2077485..2077967 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 2077967 7149948 ECIAI39_2031 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002407998.1 2077485 D 585057 CDS YP_002407999.1 218700370 7149949 2078559..2080082 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative reverse transcriptase-like protein from putative prophage or plasmid 2080082 7149949 ECIAI39_2032 Escherichia coli IAI39 putative reverse transcriptase-like protein from putative prophage or plasmid YP_002407999.1 2078559 D 585057 CDS YP_002408000.1 218700371 7150535 2080199..2080645 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 2080645 7150535 ECIAI39_2033 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002408000.1 2080199 D 585057 CDS YP_002408001.1 218700372 7149951 2081085..2082221 1 NC_011750.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase protein 2082221 potA 7149951 potA Escherichia coli IAI39 putrescine/spermidine ABC transporter ATPase protein YP_002408001.1 2081085 D 585057 CDS YP_002408002.1 218700373 7152441 2082235..2083062 1 NC_011750.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein 2083062 potB 7152441 potB Escherichia coli IAI39 spermidine/putrescine ABC transporter membrane protein YP_002408002.1 2082235 D 585057 CDS YP_002408003.1 218700374 7152442 2083059..2083853 1 NC_011750.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein 2083853 potC 7152442 potC Escherichia coli IAI39 spermidine/putrescine ABC transporter membrane protein YP_002408003.1 2083059 D 585057 CDS YP_002408004.1 218700375 7152443 2083850..2084896 1 NC_011750.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter periplasmic substrate-binding protein 2084896 potD 7152443 potD Escherichia coli IAI39 spermidine/putrescine ABC transporter periplasmic substrate-binding protein YP_002408004.1 2083850 D 585057 CDS YP_002408005.1 218700376 7152444 2084954..2085415 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2085415 ymfA 7152444 ymfA Escherichia coli IAI39 hypothetical protein YP_002408005.1 2084954 D 585057 CDS YP_002408006.1 218700377 7154384 2085412..2086200 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2086200 ycfZ 7154384 ycfZ Escherichia coli IAI39 hypothetical protein YP_002408006.1 2085412 D 585057 CDS YP_002408007.1 218700378 7153461 complement(2086338..2087159) 1 NC_011750.1 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 2087159 cobB 7153461 cobB Escherichia coli IAI39 NAD-dependent deacetylase YP_002408007.1 2086338 R 585057 CDS YP_002408008.1 218700379 7150976 complement(2087175..2088086) 1 NC_011750.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 2088086 ycfX 7150976 ycfX Escherichia coli IAI39 N-acetyl-D-glucosamine kinase YP_002408008.1 2087175 R 585057 CDS YP_002408009.1 218700380 7153460 complement(2088115..2089359) 1 NC_011750.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 2089359 lolE 7153460 lolE Escherichia coli IAI39 outer membrane-specific lipoprotein transporter subunit LolE YP_002408009.1 2088115 R 585057 CDS YP_002408010.1 218700381 7151954 complement(2089359..2090060) 1 NC_011750.1 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding subunit 2090060 lolD 7151954 lolD Escherichia coli IAI39 lipoprotein transporter ATP-binding subunit YP_002408010.1 2089359 R 585057 CDS YP_002408011.1 218700382 7151953 complement(2090053..2091252) 1 NC_011750.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC 2091252 lolC 7151953 lolC Escherichia coli IAI39 outer membrane-specific lipoprotein transporter subunit LolC YP_002408011.1 2090053 R 585057 CDS YP_002408012.1 218700383 7151952 2091514..2092587 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2092587 ycfT 7151952 ycfT Escherichia coli IAI39 hypothetical protein YP_002408012.1 2091514 D 585057 CDS YP_002408013.1 218700384 7153459 2092715..2096161 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14602898, 90158497, 92107993, 8465200; Product type f : factor; transcription-repair coupling factor 2096161 mfd 7153459 mfd Escherichia coli IAI39 transcription-repair coupling factor YP_002408013.1 2092715 D 585057 CDS YP_002408014.1 218700385 7152064 2096304..2097266 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2097266 ycfS 7152064 ycfS Escherichia coli IAI39 hypothetical protein YP_002408014.1 2096304 D 585057 CDS YP_002408015.1 218700386 7153458 complement(2097349..2097606) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089; hypothetical protein 2097606 ycfR 7153458 ycfR Escherichia coli IAI39 hypothetical protein YP_002408015.1 2097349 R 585057 CDS YP_002408016.1 218700387 7153457 2097847..2098479 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2098479 ycfQ 7153457 ycfQ Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002408016.1 2097847 D 585057 CDS YP_002408017.1 218700388 7153456 complement(2098541..2099080) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6265208, 7984428; hypothetical protein 2099080 ycfJ 7153456 ycfJ Escherichia coli IAI39 hypothetical protein YP_002408017.1 2098541 R 585057 CDS YP_002408018.1 218700389 7153451 complement(2099307..2100611) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14766919, 20130027, 81256452, 92296775, 94042945, 99441207, 6265208; Product type e : enzyme; respiratory NADH dehydrogenase 2/cupric reductase 2100611 ndh 7153451 ndh Escherichia coli IAI39 respiratory NADH dehydrogenase 2/cupric reductase YP_002408018.1 2099307 R 585057 CDS YP_002408019.1 218700390 7152202 complement(2101011..2101553) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2101553 ycfP 7152202 ycfP Escherichia coli IAI39 hypothetical protein YP_002408019.1 2101011 R 585057 CDS YP_002408020.1 218700391 7153455 complement(2101576..2102601) 1 NC_011750.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 2102601 nagZ 7153455 nagZ Escherichia coli IAI39 beta-hexosaminidase YP_002408020.1 2101576 R 585057 CDS YP_002408021.1 218700392 7152176 complement(2102612..2103436) 1 NC_011750.1 catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 2103436 thiK 7152176 thiK Escherichia coli IAI39 thiamine kinase YP_002408021.1 2102612 R 585057 CDS YP_002408022.1 218700393 7153454 complement(2103417..2104058) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein 2104058 ycfM 7153454 ycfM Escherichia coli IAI39 putative outer membrane lipoprotein YP_002408022.1 2103417 R 585057 CDS YP_002408023.1 218700394 7153453 complement(2104072..2104449) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2104449 ycfL 7153453 ycfL Escherichia coli IAI39 hypothetical protein YP_002408023.1 2104072 R 585057 CDS YP_002408024.1 218700395 7153452 complement(2104452..2104811) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15703176, 10493123, 2162465; Product type e : enzyme; purine nucleoside phosphoramidase 2104811 hinT 7153452 hinT Escherichia coli IAI39 purine nucleoside phosphoramidase YP_002408024.1 2104452 R 585057 CDS YP_002408025.1 218700396 7151319 complement(2107394..2108827) 1 NC_011750.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunits IIBC 2108827 ptsG 7151319 ptsG Escherichia coli IAI39 PTS system glucose-specific transporter subunits IIBC YP_002408025.1 2107394 R 585057 CDS YP_002408026.1 218700397 7152518 complement(2109122..2109919) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8505303, 8509334, 10747959; Product type pe : putative enzyme; putative metallodependent hydrolase 2109919 ycfH 7152518 ycfH Escherichia coli IAI39 putative metallodependent hydrolase YP_002408026.1 2109122 R 585057 CDS YP_002408027.1 218700398 7153450 complement(2109930..2110934) 1 NC_011750.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 2110934 holB 7153450 holB Escherichia coli IAI39 DNA polymerase III subunit delta' YP_002408027.1 2109930 R 585057 CDS YP_002408028.1 218700399 7151668 complement(2110931..2111572) 1 NC_011750.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 2111572 tmk 7151668 tmk Escherichia coli IAI39 thymidylate kinase YP_002408028.1 2110931 R 585057 CDS YP_002408029.1 218700400 7152992 complement(2111562..2112584) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 2112584 yceG 7152992 yceG Escherichia coli IAI39 hypothetical protein YP_002408029.1 2111562 R 585057 CDS YP_002408030.1 218700401 7153443 complement(2112587..2113396) 1 NC_011750.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 2113396 pabC 7153443 pabC Escherichia coli IAI39 4-amino-4-deoxychorismate lyase YP_002408030.1 2112587 R 585057 CDS YP_002408031.1 218700402 7152321 complement(2113516..2114757) 1 NC_011750.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 2114757 fabF 7152321 fabF Escherichia coli IAI39 3-oxoacyl-(acyl carrier protein) synthase II YP_002408031.1 2113516 R 585057 CDS YP_002408032.1 218700403 7151266 complement(2114845..2115081) 1 NC_011750.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 2115081 acpP 7151266 acpP Escherichia coli IAI39 acyl carrier protein YP_002408032.1 2114845 R 585057 CDS YP_002408033.1 218700404 7150669 complement(2115292..2116026) 1 NC_011750.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 2116026 fabG 7150669 fabG Escherichia coli IAI39 3-ketoacyl-(acyl-carrier-protein) reductase YP_002408033.1 2115292 R 585057 CDS YP_002408034.1 218700405 7151267 complement(2116039..2116968) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92052166, 92183950, 92210530, 92234941, 7700236, 7768883, 9298646; Product type e : enzyme; malonyl-CoA-[acyl-carrier-protein] transacylase 2116968 fabD 7151267 fabD Escherichia coli IAI39 malonyl-CoA-[acyl-carrier-protein] transacylase YP_002408034.1 2116039 R 585057 CDS YP_002408035.1 218700406 7151265 complement(2116984..2117937) 1 NC_011750.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III 2117937 fabH 7151265 fabH Escherichia coli IAI39 3-oxoacyl-(acyl carrier protein) synthase III YP_002408035.1 2116984 R 585057 CDS YP_002408036.1 218700407 7151268 complement(2118005..2119075) 1 NC_011750.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX 2119075 plsX 7151268 plsX Escherichia coli IAI39 putative glycerol-3-phosphate acyltransferase PlsX YP_002408036.1 2118005 R 585057 CDS YP_002408037.1 218700408 7152429 complement(2119156..2119329) 1 NC_011750.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 2119329 rpmF 7152429 rpmF Escherichia coli IAI39 50S ribosomal protein L32 YP_002408037.1 2119156 R 585057 CDS YP_002408038.1 218700409 7152699 complement(2119381..2119902) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 90008815, 1447160; hypothetical protein 2119902 yceD 7152699 yceD Escherichia coli IAI39 hypothetical protein YP_002408038.1 2119381 R 585057 CDS YP_002408039.1 218700410 7152893 2120101..2120685 1 NC_011750.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 2120685 yceF 7152893 yceF Escherichia coli IAI39 Maf-like protein YP_002408039.1 2120101 D 585057 CDS YP_002408040.1 218700411 7153442 complement(2120797..2121756) 1 NC_011750.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 2121756 rluC 7153442 rluC Escherichia coli IAI39 23S rRNA pseudouridylate synthase C YP_002408040.1 2120797 R 585057 CDS YP_002408041.1 218700412 7150536 2122329..2125514 1 NC_011750.1 bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E 2125514 rne 7150536 rne Escherichia coli IAI39 ribonuclease E YP_002408041.1 2122329 D 585057 CDS YP_002408042.1 218700413 7152656 2125603..2125941 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2125941 7152656 ECIAI39_2077 Escherichia coli IAI39 hypothetical protein YP_002408042.1 2125603 D 585057 CDS YP_002408043.1 218700414 7149952 2125923..2126432 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2126432 7149952 ECIAI39_2078 Escherichia coli IAI39 hypothetical protein YP_002408043.1 2125923 D 585057 CDS YP_002408044.1 218700415 7149953 complement(2126527..2127480) 1 NC_011750.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; flagellar hook-associated protein FlgL 2127480 flgL 7149953 flgL Escherichia coli IAI39 flagellar hook-associated protein FlgL YP_002408044.1 2126527 R 585057 CDS YP_002408045.1 218700416 7151361 complement(2127492..2129135) 1 NC_011750.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 2129135 flgK 7151361 flgK Escherichia coli IAI39 flagellar hook-associated protein FlgK YP_002408045.1 2127492 R 585057 CDS YP_002408046.1 218700417 7151360 complement(2129201..2130142) 1 NC_011750.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 2130142 flgJ 7151360 flgJ Escherichia coli IAI39 flagellar rod assembly protein/muramidase FlgJ YP_002408046.1 2129201 R 585057 CDS YP_002408047.1 218700418 7151358 complement(2131251..2131949) 1 NC_011750.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 2131949 flgH 7151358 flgH Escherichia coli IAI39 flagellar basal body L-ring protein YP_002408047.1 2131251 R 585057 CDS YP_002408048.1 218700419 7151356 complement(2132002..2132784) 1 NC_011750.1 makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 2132784 flgG 7151356 flgG Escherichia coli IAI39 flagellar basal body rod protein FlgG YP_002408048.1 2132002 R 585057 CDS YP_002408049.1 218700420 7151355 complement(2132921..2133676) 1 NC_011750.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF 2133676 flgF 7151355 flgF Escherichia coli IAI39 flagellar basal body rod protein FlgF YP_002408049.1 2132921 R 585057 CDS YP_002408050.1 218700421 7151354 complement(2133696..2134898) 1 NC_011750.1 the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 2134898 flgE 7151354 flgE Escherichia coli IAI39 flagellar hook protein FlgE YP_002408050.1 2133696 R 585057 CDS YP_002408051.1 218700422 7151353 complement(2134923..2135618) 1 NC_011750.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein 2135618 flgD 7151353 flgD Escherichia coli IAI39 flagellar basal body rod modification protein YP_002408051.1 2134923 R 585057 CDS YP_002408052.1 218700423 7151352 complement(2135630..2136034) 1 NC_011750.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 2136034 flgC 7151352 flgC Escherichia coli IAI39 flagellar basal body rod protein FlgC YP_002408052.1 2135630 R 585057 CDS YP_002408053.1 218700424 7151351 complement(2136038..2136454) 1 NC_011750.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal body rod protein FlgB 2136454 flgB 7151351 flgB Escherichia coli IAI39 flagellar basal body rod protein FlgB YP_002408053.1 2136038 R 585057 CDS YP_002408054.1 218700425 7151350 2136609..2137268 1 NC_011750.1 required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA 2137268 flgA 7151350 flgA Escherichia coli IAI39 flagellar basal body P-ring biosynthesis protein FlgA YP_002408054.1 2136609 D 585057 CDS YP_002408055.1 218700426 7151349 2137344..2137634 1 NC_011750.1 regulates the flagellar specific sigma28 transcription factor; anti-sigma28 factor FlgM 2137634 flgM 7151349 flgM Escherichia coli IAI39 anti-sigma28 factor FlgM YP_002408055.1 2137344 D 585057 CDS YP_002408056.1 218700427 7151362 2137639..2138055 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10320579; Product type f : factor; export chaperone for FlgK and FlgL 2138055 flgN 7151362 flgN Escherichia coli IAI39 export chaperone for FlgK and FlgL YP_002408056.1 2137639 D 585057 CDS YP_002408057.1 218700428 7151363 complement(2138095..2139630) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2139630 mviN 7151363 mviN Escherichia coli IAI39 hypothetical protein YP_002408057.1 2138095 R 585057 CDS YP_002408058.1 218700429 7152162 complement(2139740..2140663) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 2140663 mviM 7152162 mviM Escherichia coli IAI39 putative oxidoreductase YP_002408058.1 2139740 R 585057 CDS YP_002408059.1 218700430 7152161 complement(2140665..2141312) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1356970, 2828880; hypothetical protein 2141312 yceH 7152161 yceH Escherichia coli IAI39 hypothetical protein YP_002408059.1 2140665 R 585057 CDS YP_002408060.1 218700431 7153444 complement(2141323..2141907) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88121676, 90136529, 1356970; Product type e : enzyme; ribosomal-protein-S5-alanine N-acetyltransferase 2141907 rimJ 7153444 rimJ Escherichia coli IAI39 ribosomal-protein-S5-alanine N-acetyltransferase YP_002408060.1 2141323 R 585057 CDS YP_002408061.1 218700432 7152635 2142143..2143351 1 NC_011750.1 Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH 2143351 mdtH 7152635 mdtH Escherichia coli IAI39 multidrug resistance protein MdtH YP_002408061.1 2142143 D 585057 CDS YP_002408062.1 218700433 7152035 2143415..2144062 1 NC_011750.1 cofactor involved in the reduction of disulfides; glutaredoxin 2 2144062 grxB 7152035 grxB Escherichia coli IAI39 glutaredoxin 2 YP_002408062.1 2143415 D 585057 CDS YP_002408063.1 218700434 7151589 2144196..2144756 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 2144756 yceB 7151589 yceB Escherichia coli IAI39 hypothetical protein YP_002408063.1 2144196 D 585057 CDS YP_002408064.1 218700435 7153440 2144862..2145908 1 NC_011750.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 2145908 pyrC 7153440 pyrC Escherichia coli IAI39 dihydroorotase YP_002408064.1 2144862 D 585057 CDS YP_002408065.2 229598879 7152549 2145982..2146227 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11230150, 11152126; Product type f : factor; DNA damage-inducible protein I 2146227 dinI 7152549 dinI Escherichia coli IAI39 DNA damage-inducible protein I YP_002408065.2 2145982 D 585057 CDS YP_002408066.1 218700437 7151141 2146517..2146771 1 NC_011750.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS 2146771 bssS 7151141 bssS Escherichia coli IAI39 biofilm formation regulatory protein BssS YP_002408066.1 2146517 D 585057 CDS YP_002408067.1 218700438 7150877 2146886..2148004 1 NC_011750.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase 2148004 solA 7150877 solA Escherichia coli IAI39 N-methyltryptophan oxidase YP_002408067.1 2146886 D 585057 CDS YP_002408068.1 218700439 7152876 2148025..2148165 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2148165 yceO 7152876 yceO Escherichia coli IAI39 hypothetical protein YP_002408068.1 2148025 D 585057 CDS YP_002408069.1 218700440 7153448 2148426..2148992 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative cytochrome b561 2148992 yceJ 7153448 yceJ Escherichia coli IAI39 putative cytochrome b561 YP_002408069.1 2148426 D 585057 CDS YP_002408070.1 218700441 7153446 complement(2148759..2148926) 1 NC_011750.1 hypothetical protein 2148926 7153446 ECIAI39_2107 Escherichia coli IAI39 hypothetical protein YP_002408070.1 2148759 R 585057 CDS YP_002408071.1 218700442 7149954 2148996..2149571 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15741337, 11298273, 1840644, 9298646; Product type c : carrier; hypothetical protein 2149571 yceI 7149954 yceI Escherichia coli IAI39 hypothetical protein YP_002408071.1 2148996 D 585057 CDS YP_002408072.1 218700443 7153445 complement(2149613..2150665) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1840644; hypothetical protein 2150665 yceA 7153445 yceA Escherichia coli IAI39 hypothetical protein YP_002408072.1 2149613 R 585057 CDS YP_002408073.1 218700444 7153439 2150890..2151810 1 NC_011750.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 2151810 lpxL 7153439 lpxL Escherichia coli IAI39 lipid A biosynthesis lauroyl acyltransferase YP_002408073.1 2150890 D 585057 CDS YP_002408074.1 218700445 7151971 2151982..2153208 1 NC_011750.1 Confers resistance to fosfomycin and deoxycholate; drug efflux system protein MdtG 2153208 mdtG 7151971 mdtG Escherichia coli IAI39 drug efflux system protein MdtG YP_002408074.1 2151982 D 585057 CDS YP_002408075.1 218700446 7152034 2153291..2153665 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 92165719; hypothetical protein 2153665 msyB 7152034 msyB Escherichia coli IAI39 hypothetical protein YP_002408075.1 2153291 D 585057 CDS YP_002408076.1 218700447 7152136 complement(2153666..2153893) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 2153893 yceK 7152136 yceK Escherichia coli IAI39 hypothetical protein YP_002408076.1 2153666 R 585057 CDS YP_002408077.1 218700448 7153447 complement(2154098..2156641) 1 NC_011750.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 2156641 mdoH 7153447 mdoH Escherichia coli IAI39 glucosyltransferase MdoH YP_002408077.1 2154098 R 585057 CDS YP_002408078.1 218700449 7152027 complement(2156634..2158169) 1 NC_011750.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 2158169 mdoG 7152027 mdoG Escherichia coli IAI39 glucan biosynthesis protein G YP_002408078.1 2156634 R 585057 CDS YP_002408079.1 218700450 7152026 2158563..2159720 1 NC_011750.1 required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein 2159720 mdoC 7152026 mdoC Escherichia coli IAI39 glucans biosynthesis protein YP_002408079.1 2158563 D 585057 CDS YP_002408080.1 218700451 7152025 complement(2159728..2161149) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 2161149 ymdC 7152025 ymdC Escherichia coli IAI39 putative hydrolase YP_002408080.1 2159728 R 585057 CDS YP_002408081.1 218700452 7154383 complement(2161151..2161684) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2161684 ymdB 7154383 ymdB Escherichia coli IAI39 hypothetical protein YP_002408081.1 2161151 R 585057 CDS YP_002408082.1 218700453 7154382 complement(2161779..2162090) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2162090 ymdA 7154382 ymdA Escherichia coli IAI39 hypothetical protein YP_002408082.1 2161779 R 585057 CDS YP_002408083.1 218700454 7154381 complement(2162211..2162543) 1 NC_011750.1 involved in autoagglutination of curliated cells; not involved in production of curli fibers; putative autoagglutination protein 2162543 csgC 7154381 csgC Escherichia coli IAI39 putative autoagglutination protein YP_002408083.1 2162211 R 585057 CDS YP_002408084.1 218700455 7151005 complement(2162602..2163057) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89201357, 93023873, 1677357, 8459772, 8817489, 1357528; Product type s : structure; cryptic curlin major subunit 2163057 csgA 7151005 csgA Escherichia coli IAI39 cryptic curlin major subunit YP_002408084.1 2162602 R 585057 CDS YP_002408085.1 218700456 7151003 complement(2163098..2163553) 1 NC_011750.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit 2163553 csgB 7151003 csgB Escherichia coli IAI39 curlin minor subunit YP_002408085.1 2163098 R 585057 CDS YP_002408086.1 218700457 7151004 2164308..2164958 1 NC_011750.1 activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD 2164958 csgD 7151004 csgD Escherichia coli IAI39 DNA-binding transcriptional regulator CsgD YP_002408086.1 2164308 D 585057 CDS YP_002408087.1 218700458 7151006 2164963..2165352 1 NC_011750.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE 2165352 csgE 7151006 csgE Escherichia coli IAI39 curli assembly protein CsgE YP_002408087.1 2164963 D 585057 CDS YP_002408088.1 218700459 7151007 2165377..2165793 1 NC_011750.1 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF 2165793 csgF 7151007 csgF Escherichia coli IAI39 curli assembly protein CsgF YP_002408088.1 2165377 D 585057 CDS YP_002408089.1 218700460 7151008 2165820..2166653 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8817489; Product type lp : lipoprotein; putative outer membrane lipoprotein involved in curli production assembly/transport 2166653 csgG 7151008 csgG Escherichia coli IAI39 putative outer membrane lipoprotein involved in curli production assembly/transport YP_002408089.1 2165820 D 585057 CDS YP_002408090.1 218700461 7151009 complement(2166717..2167208) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2167208 ycdZ 7151009 ycdZ Escherichia coli IAI39 hypothetical protein YP_002408090.1 2166717 R 585057 CDS YP_002408091.1 218700462 7153438 complement(2167310..2167864) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2167864 ycdY 7153438 ycdY Escherichia coli IAI39 hypothetical protein YP_002408091.1 2167310 R 585057 CDS YP_002408092.1 218700463 7153437 complement(2167888..2168625) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12661000; Product type pe : putative enzyme; putative hydrolase 2168625 ycdX 7153437 ycdX Escherichia coli IAI39 putative hydrolase YP_002408092.1 2167888 R 585057 CDS YP_002408093.1 218700464 7153436 complement(2168680..2169618) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11237876, 10493123; Product type e : enzyme; 2-ketoacid reductase 2169618 ycdW 7153436 ycdW Escherichia coli IAI39 2-ketoacid reductase YP_002408093.1 2168680 R 585057 CDS YP_002408094.1 218700465 7150556 complement(2170044..2171501) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 99392474; Product type pe : putative enzyme; putative diguanylate cyclase 2171501 ycdT 7150556 ycdT Escherichia coli IAI39 putative diguanylate cyclase YP_002408094.1 2170044 R 585057 CDS YP_002408095.1 218700466 7153434 2172001..2174424 1 NC_011750.1 outer membrane protein essential for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PGA); adhesin required for biofilm formation; PgaA (HmsH) seems to translocate and/or dock PGA to the cell surface; member of the hmsHFRS (ycdSRQP or pgaABCD in Escherichia coli) operon in Yersinia; outer membrane protein PgaA 2174424 pgaA 7153434 pgaA Escherichia coli IAI39 outer membrane protein PgaA YP_002408095.1 2172001 D 585057 CDS YP_002408096.1 218700467 7152377 2174433..2176451 1 NC_011750.1 in Yersinia this protein is involved in biofilm formation and hemin adsorption; related protein PgaB in Escherichia coli is an outer membrane N-deacetylase involved in poly-beta-1,6-N-acetyl-D-glucosamine (PGA) export; outer membrane N-deacetylase 2176451 pgaB 7152377 pgaB Escherichia coli IAI39 outer membrane N-deacetylase YP_002408096.1 2174433 D 585057 CDS YP_002408097.1 218700468 7152378 2176444..2177718 1 NC_011750.1 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein; N-glycosyltransferase 2177718 pgaC 7152378 pgaC Escherichia coli IAI39 N-glycosyltransferase YP_002408097.1 2176444 D 585057 CDS YP_002408098.1 218700469 7152379 2177772..2178185 1 NC_011750.1 in Yersinia this gene is involved in biofilm formation and hemin adsorption; in Escherichia coli it is involved in PGA biosynthesis and export; putative PGA biosynthesis protein 2178185 pgaD 7152379 pgaD Escherichia coli IAI39 putative PGA biosynthesis protein YP_002408098.1 2177772 D 585057 CDS YP_002408099.1 218700470 7152380 complement(2178235..2179299) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8444794, 2160940; Product type pe : putative enzyme; hypothetical protein 2179299 phoH 7152380 phoH Escherichia coli IAI39 hypothetical protein YP_002408099.1 2178235 R 585057 CDS YP_002408100.1 218700471 7152412 complement(2179544..2180815) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17627767, 16551627, 15375152; Product type t : transporter; iron transport heme-binding periplasmic protein 2180815 efeB 7152412 efeB Escherichia coli IAI39 iron transport heme-binding periplasmic protein YP_002408100.1 2179544 R 585057 CDS YP_002408101.1 218700472 7151204 complement(2180821..2181948) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17627767, 10493123; Product type t : transporter; hypothetical protein 2181948 efeO 7151204 efeO Escherichia coli IAI39 hypothetical protein YP_002408101.1 2180821 R 585057 CDS YP_002408102.1 218700473 7151205 complement(2182006..2182845) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter; ferrous iron permease 2182845 efeU 7151205 efeU Escherichia coli IAI39 ferrous iron permease YP_002408102.1 2182006 R 585057 CDS YP_002408103.1 218700474 7151206 complement(2183056..2184564) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12923181, 88213396, 91227628, 93132799, 98359785, 1400239, 1567896, 3053649, 3053687, 3302614, 3325781, 8119910; Product type t : transporter; proline:sodium symporter 2184564 putP 7151206 putP Escherichia coli IAI39 proline:sodium symporter YP_002408103.1 2183056 R 585057 CDS YP_002408104.1 218700475 7152538 2184987..2188949 1 NC_011750.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein; trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 2188949 putA 7152538 putA Escherichia coli IAI39 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase YP_002408104.1 2184987 D 585057 CDS YP_002408105.1 218700476 7152537 complement(2188989..2189627) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type r : regulator; alternative pyrimidine degradation pathway DNA-binding transcriptional regulator 2189627 rutR 7152537 rutR Escherichia coli IAI39 alternative pyrimidine degradation pathway DNA-binding transcriptional regulator YP_002408105.1 2188989 R 585057 CDS YP_002408106.1 218700477 7152772 2189825..2190820 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; alternative pyrimidine degradation pathway monooxygenase 2190820 rutA 7152772 rutA Escherichia coli IAI39 alternative pyrimidine degradation pathway monooxygenase YP_002408106.1 2189825 D 585057 CDS YP_002408107.1 218700478 7152765 2190867..2191559 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; alternative pyrimidine degradation pathway protein 2191559 rutB 7152765 rutB Escherichia coli IAI39 alternative pyrimidine degradation pathway protein YP_002408107.1 2190867 D 585057 CDS YP_002408108.1 218700479 7152766 2191571..2191957 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; alternative pyrimidine degradation pathway protein 2191957 rutC 7152766 rutC Escherichia coli IAI39 alternative pyrimidine degradation pathway protein YP_002408108.1 2191571 D 585057 CDS YP_002408109.1 218700480 7152767 2191965..2192765 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; alternative pyrimidine degradation pathway protein 2192765 rutD 7152767 rutD Escherichia coli IAI39 alternative pyrimidine degradation pathway protein YP_002408109.1 2191965 D 585057 CDS YP_002408110.1 218700481 7152768 2192775..2193365 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; hypothetical protein 2193365 rutE 7152768 rutE Escherichia coli IAI39 hypothetical protein YP_002408110.1 2192775 D 585057 CDS YP_002408111.1 218700482 7152769 2193376..2193870 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542, 10633095; Product type e : enzyme; alternative pyrimidine degradation pathway flavin:NADH oxidoreductase subunit 2193870 rutF 7152769 rutF Escherichia coli IAI39 alternative pyrimidine degradation pathway flavin:NADH oxidoreductase subunit YP_002408111.1 2193376 D 585057 CDS YP_002408112.1 218700483 7152770 2193891..2195219 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type t : transporter; pyrimidine transporter 2195219 rutG 7152770 rutG Escherichia coli IAI39 pyrimidine transporter YP_002408112.1 2193891 D 585057 CDS YP_002408113.1 218700484 7152771 2195848..2196444 1 NC_011750.1 stationary phase protein that binds TrpR repressor; TrpR binding protein WrbA 2196444 wrbA 7152771 wrbA Escherichia coli IAI39 TrpR binding protein WrbA YP_002408113.1 2195848 D 585057 CDS YP_002408114.1 218700485 7153161 2196465..2196692 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2196692 yccJ 7153161 yccJ Escherichia coli IAI39 hypothetical protein YP_002408114.1 2196465 D 585057 CDS YP_002408115.1 218700486 7153425 complement(2196730..2197971) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12455612, 90368616, 91297199, 2153660, 9298646; Product type e : enzyme; glucose-1-phosphatase/inositol phosphatase 2197971 agp 7153425 agp Escherichia coli IAI39 glucose-1-phosphatase/inositol phosphatase YP_002408115.1 2196730 R 585057 CDS YP_002408116.1 218700487 7150705 complement(2198264..2199520) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8302830; hypothetical protein 2199520 yccE 7150705 yccE Escherichia coli IAI39 hypothetical protein YP_002408116.1 2198264 R 585057 CDS YP_002408117.1 218700488 7153423 2199780..2200700 1 NC_011750.1 functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA 2200700 cbpA 7153423 cbpA Escherichia coli IAI39 curved DNA-binding protein CbpA YP_002408117.1 2199780 D 585057 CDS YP_002408118.1 218700489 7150905 2200700..2201005 1 NC_011750.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM 2201005 cbpM 7150905 cbpM Escherichia coli IAI39 chaperone-modulator protein CbpM YP_002408118.1 2200700 D 585057 CDS YP_002408119.1 218700490 7150906 complement(2201157..2201756) 1 NC_011750.1 TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; chaperone protein TorD 2201756 torD 7150906 torD Escherichia coli IAI39 chaperone protein TorD YP_002408119.1 2201157 R 585057 CDS YP_002408120.1 218700491 7153006 complement(2201753..2204299) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88193091, 90089471, 94293785, 8302830, 8022286; Product type e : enzyme; trimethylamine N-oxide (TMAO) reductase I, catalytic subunit 2204299 torA 7153006 torA Escherichia coli IAI39 trimethylamine N-oxide (TMAO) reductase I, catalytic subunit YP_002408120.1 2201753 R 585057 CDS YP_002408121.1 218700492 7153004 complement(2204299..2205471) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293785, 94314186, 99340208, 11056172, 11562502; Product type c : carrier; trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit 2205471 torC 7153004 torC Escherichia coli IAI39 trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit YP_002408121.1 2204299 R 585057 CDS YP_002408122.1 218700493 7153005 2205601..2206293 1 NC_011750.1 response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR 2206293 torR 7153005 torR Escherichia coli IAI39 DNA-binding transcriptional regulator TorR YP_002408122.1 2205601 D 585057 CDS YP_002408123.1 218700494 7153007 complement(2206266..2207294) 1 NC_011750.1 periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 2207294 torT 7153007 torT Escherichia coli IAI39 TMAO reductase system periplasmic protein TorT YP_002408123.1 2206266 R 585057 CDS YP_002408124.1 218700495 7153009 2207377..2210121 1 NC_011750.1 Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide; hybrid sensory histidine kinase TorS 2210121 torS 7153009 torS Escherichia coli IAI39 hybrid sensory histidine kinase TorS YP_002408124.1 2207377 D 585057 CDS YP_002408125.1 218700496 7153008 2210193..2211266 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S membrane protein 2211266 yccM 7153008 yccM Escherichia coli IAI39 putative 4Fe-4S membrane protein YP_002408125.1 2210193 D 585057 CDS YP_002408126.1 218700497 7153426 complement(2211315..2211488) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15317805, 11544213; Product type pr : putative regulator; putative regulator of phosphatidylethanolamine synthesis 2211488 gnsA 7153426 gnsA Escherichia coli IAI39 putative regulator of phosphatidylethanolamine synthesis YP_002408126.1 2211315 R 585057 CDS YP_002408127.1 218700498 7151567 complement(2211882..2212094) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9484881, 15466053, 8631696, 9439003; Product type r : regulator; cold shock protein CspG 2212094 cspG 7151567 cspG Escherichia coli IAI39 cold shock protein CspG YP_002408127.1 2211882 R 585057 CDS YP_002408128.1 218700499 7151018 2212380..2212592 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9484881, 9439003; Product type f : factor; stress protein, member of the CspA-family 2212592 cspH 7151018 cspH Escherichia coli IAI39 stress protein, member of the CspA-family YP_002408128.1 2212380 D 585057 CDS YP_002408129.1 218700500 7151019 complement(2212580..2213878) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20122624, 92049231, 93054596, 10696472, 2168385, 3038201, 8387749; Product type e : enzyme; phosphoanhydride phosphorylase 2213878 appA 7151019 appA Escherichia coli IAI39 phosphoanhydride phosphorylase YP_002408129.1 2212580 R 585057 CDS YP_002408130.1 218700501 7150742 complement(2214075..2215211) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92049231, 96198179; Product type c : carrier; cytochrome bd-II oxidase subunit II 2215211 appB 7150742 appB Escherichia coli IAI39 cytochrome bd-II oxidase subunit II YP_002408130.1 2214075 R 585057 CDS YP_002408131.1 218700502 7150743 complement(2215223..2216767) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92049231, 96198179; Product type c : carrier; cytochrome bd-II oxidase subunit I 2216767 appC 7150743 appC Escherichia coli IAI39 cytochrome bd-II oxidase subunit I YP_002408131.1 2215223 R 585057 CDS YP_002408132.1 218700503 7150744 complement(2216901..2217758) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202716, 91310595, 92215587; Product type f : factor; hydrogenase-1 nickel incorportation protein 2217758 hyaF 7150744 hyaF Escherichia coli IAI39 hydrogenase-1 nickel incorportation protein YP_002408132.1 2216901 R 585057 CDS YP_002408133.1 218700504 7151702 complement(2217755..2218153) 1 NC_011750.1 involved in processing hydrogenase proteins HyaA and HyaB; hydrogenase-1 operon protein HyaE 2218153 hyaE 7151702 hyaE Escherichia coli IAI39 hydrogenase-1 operon protein HyaE YP_002408133.1 2217755 R 585057 CDS YP_002408134.1 218700505 7151701 complement(2218150..2218737) 1 NC_011750.1 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 2218737 hyaD 7151701 hyaD Escherichia coli IAI39 hydrogenase 1 maturation protease YP_002408134.1 2218150 R 585057 CDS YP_002408135.1 218700506 7151700 complement(2218734..2219441) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202716, 91310595, 92215587; Product type c : carrier; hydrogenase 1 b-type cytochrome subunit 2219441 hyaC 7151700 hyaC Escherichia coli IAI39 hydrogenase 1 b-type cytochrome subunit YP_002408135.1 2218734 R 585057 CDS YP_002408136.1 218700507 7151699 complement(2219460..2221253) 1 NC_011750.1 involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit 2221253 hyaB 7151699 hyaB Escherichia coli IAI39 hydrogenase 1 large subunit YP_002408136.1 2219460 R 585057 CDS YP_002408137.1 218700508 7151698 complement(2221250..2222368) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86192450, 90202716, 92215587; Product type e : enzyme; hydrogenase 1, small subunit 2222368 hyaA 7151698 hyaA Escherichia coli IAI39 hydrogenase 1, small subunit YP_002408137.1 2221250 R 585057 CDS YP_002408138.1 218700509 7150557 2223089..2223748 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6376117; Product type m : membrane component; hypothetical protein 2223748 yccA 7150557 yccA Escherichia coli IAI39 hypothetical protein YP_002408138.1 2223089 D 585057 CDS YP_002408139.1 218700510 7153422 2223840..2224169 1 NC_011750.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE 2224169 tusE 7153422 tusE Escherichia coli IAI39 sulfur transfer protein TusE YP_002408139.1 2223840 D 585057 CDS YP_002408140.1 218700511 7153061 complement(2224166..2224657) 1 NC_011750.1 catalyzes the hydrolysis of acylphosphate; acylphosphatase 2224657 yccX 7153061 yccX Escherichia coli IAI39 acylphosphatase YP_002408140.1 2224166 R 585057 CDS YP_002408141.1 218700512 7153433 2224626..2225729 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative AdoMet-dependent methyltransferase 2225729 yccW 7153433 yccW Escherichia coli IAI39 putative AdoMet-dependent methyltransferase YP_002408141.1 2224626 D 585057 CDS YP_002408142.1 218700513 7153432 2225787..2226104 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12700277, 15569148; Product type f : factor; heat shock protein HspQ 2226104 yccV 7153432 yccV Escherichia coli IAI39 heat shock protein HspQ YP_002408142.1 2225787 D 585057 CDS YP_002408143.1 218700514 7153431 complement(2226149..2226562) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative CoA-binding protein 2226562 yccU 7153431 yccU Escherichia coli IAI39 putative CoA-binding protein YP_002408143.1 2226149 R 585057 CDS YP_002408144.1 218700515 7153430 2226525..2226695 1 NC_011750.1 hypothetical protein 2226695 7153430 ECIAI39_2181 Escherichia coli IAI39 hypothetical protein YP_002408144.1 2226525 D 585057 CDS YP_002408145.1 218700516 7149955 2226735..2227397 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2227397 yccT 7149955 yccT Escherichia coli IAI39 hypothetical protein YP_002408145.1 2226735 D 585057 CDS YP_002408146.1 218700517 7153429 2227493..2227951 1 NC_011750.1 catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 2227951 mgsA 7153429 mgsA Escherichia coli IAI39 methylglyoxal synthase YP_002408146.1 2227493 D 585057 CDS YP_002408147.1 218700518 7152068 complement(2227983..2230037) 1 NC_011750.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 2230037 helD 7152068 helD Escherichia coli IAI39 DNA helicase IV YP_002408147.1 2227983 R 585057 CDS YP_002408148.1 218700519 7151623 2230160..2230606 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2230606 yccF 7151623 yccF Escherichia coli IAI39 hypothetical protein YP_002408148.1 2230160 D 585057 CDS YP_002408149.1 218700520 7153424 2230625..2232778 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2232778 yccS 7153424 yccS Escherichia coli IAI39 hypothetical protein YP_002408149.1 2230625 D 585057 CDS YP_002408150.1 218700521 7153428 complement(2232741..2233370) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2233370 yccR 7153428 yccR Escherichia coli IAI39 hypothetical protein YP_002408150.1 2232741 R 585057 CDS YP_002408151.1 218700522 7153427 2233588..2234097 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10368140, 91072263, 93163041, 98348458, 3297925, 6253901, 6306396; Product type cp : cell process; SOS cell division inhibitor 2234097 sulA 7153427 sulA Escherichia coli IAI39 SOS cell division inhibitor YP_002408151.1 2233588 D 585057 CDS YP_002408152.1 218700523 7151850 complement(2234081..2234299) 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 2234299 7151850 ECIAI39_2189 Escherichia coli IAI39 hypothetical protein YP_002408152.1 2234081 R 585057 CDS YP_002408153.1 218700524 7149956 2234382..2235506 1 NC_011750.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein A 2235506 ompA 7149956 ompA Escherichia coli IAI39 outer membrane protein A YP_002408153.1 2234382 D 585057 CDS YP_002408154.1 218700525 7152290 complement(2235583..2236035) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2236035 ycbG 7152290 ycbG Escherichia coli IAI39 hypothetical protein YP_002408154.1 2235583 R 585057 CDS YP_002408155.1 218700526 7153408 2236221..2237981 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-dependent protease 2237981 ycbZ 7153408 ycbZ Escherichia coli IAI39 putative ATP-dependent protease YP_002408155.1 2236221 D 585057 CDS YP_002408156.1 218700527 7153421 2238050..2238568 1 NC_011750.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-(acyl carrier protein) dehydratase 2238568 fabA 7153421 fabA Escherichia coli IAI39 3-hydroxydecanoyl-(acyl carrier protein) dehydratase YP_002408156.1 2238050 D 585057 CDS YP_002408157.1 218700528 7151263 complement(2238638..2238805) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1101029, 90207255, 2832401, 8440252; Product type f : factor; ribosome modulation factor 2238805 rmf 7151263 rmf Escherichia coli IAI39 ribosome modulation factor YP_002408157.1 2238638 R 585057 CDS YP_002408158.1 218700529 7152645 complement(2239061..2239609) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2239609 ymbA 7152645 ymbA Escherichia coli IAI39 hypothetical protein YP_002408158.1 2239061 R 585057 CDS YP_002408159.1 218700530 7154380 complement(2239621..2241261) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95270582; Product type cp : cell process; paraquat-inducible protein B 2241261 pqiB 7154380 pqiB Escherichia coli IAI39 paraquat-inducible protein B YP_002408159.1 2239621 R 585057 CDS YP_002408160.1 218700531 7152469 complement(2241266..2242519) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95270582; Product type cp : cell process; paraquat-inducible membrane protein A 2242519 pqiA 7152469 pqiA Escherichia coli IAI39 paraquat-inducible membrane protein A YP_002408160.1 2241266 R 585057 CDS YP_002408161.1 218700532 7152468 complement(2242649..2244556) 1 NC_011750.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 2244556 uup 7152468 uup Escherichia coli IAI39 ABC transporter ATPase YP_002408161.1 2242649 R 585057 CDS YP_002408162.1 218700533 7153112 complement(2244568..2246676) 1 NC_011750.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 2246676 rlmL 7153112 rlmL Escherichia coli IAI39 23S rRNA m(2)G2445 methyltransferase YP_002408162.1 2244568 R 585057 CDS YP_002408163.1 218700534 7153420 2246774..2247883 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1327782; Product type pe : putative enzyme; putative 2Fe-2S cluster-containing protein 2247883 ycbX 7153420 ycbX Escherichia coli IAI39 putative 2Fe-2S cluster-containing protein YP_002408163.1 2246774 D 585057 CDS YP_002408164.1 218700535 7153419 complement(2247880..2248422) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2248422 ycbW 7153419 ycbW Escherichia coli IAI39 hypothetical protein YP_002408164.1 2247880 R 585057 CDS YP_002408165.1 218700536 7153418 complement(2248596..2249606) 1 NC_011750.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 2249606 pyrD 7153418 pyrD Escherichia coli IAI39 dihydroorotate dehydrogenase 2 YP_002408165.1 2248596 R 585057 CDS YP_002408166.1 218700537 7152550 complement(2249717..2250427) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putativi pili assembly chaperone 2250427 ycbF 7152550 ycbF Escherichia coli IAI39 putativi pili assembly chaperone YP_002408166.1 2249717 R 585057 CDS YP_002408167.1 218700538 7153407 complement(2250420..2250935) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative exported fimbrial-like adhesin protein 2250935 ycbV 7153407 ycbV Escherichia coli IAI39 putative exported fimbrial-like adhesin protein YP_002408167.1 2250420 R 585057 CDS YP_002408168.1 218700539 7153417 complement(2250943..2251485) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein 2251485 ycbU 7153417 ycbU Escherichia coli IAI39 putative fimbrial-like adhesin protein YP_002408168.1 2250943 R 585057 CDS YP_002408169.1 218700540 7153416 complement(2251497..2252567) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7721701; Product type ps : putative structure; putative fimbrial-like adhesin protein 2252567 ycbT 7153416 ycbT Escherichia coli IAI39 putative fimbrial-like adhesin protein YP_002408169.1 2251497 R 585057 CDS YP_002408170.1 218700541 7153415 complement(2252558..2255158) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative outer membrane export usher protein 2255158 ycbS 7153415 ycbS Escherichia coli IAI39 putative outer membrane export usher protein YP_002408170.1 2252558 R 585057 CDS YP_002408171.1 218700542 7153414 complement(2255183..2255884) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative periplasmic pilin chaperone 2255884 ycbR 7153414 ycbR Escherichia coli IAI39 putative periplasmic pilin chaperone YP_002408171.1 2255183 R 585057 CDS YP_002408172.1 218700543 7153413 complement(2255965..2256504) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type ps : putative structure; putative fimbrial-like adhesin protein 2256504 ycbQ 7153413 ycbQ Escherichia coli IAI39 putative fimbrial-like adhesin protein YP_002408172.1 2255965 R 585057 CDS YP_002408173.1 218700544 7153412 2256860..2257435 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20245523, 99410391, 99436146, 8774726; Product type e : enzyme; NAD(P)H-dependent FMN reductase 2257435 ssuE 7153412 ssuE Escherichia coli IAI39 NAD(P)H-dependent FMN reductase YP_002408173.1 2256860 D 585057 CDS YP_002408174.1 218700545 7152915 2257428..2258387 1 NC_011750.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit 2258387 ssuA 7152915 ssuA Escherichia coli IAI39 alkanesulfonate transporter substrate-binding subunit YP_002408174.1 2257428 D 585057 CDS YP_002408175.1 218700546 7152911 2258384..2259529 1 NC_011750.1 catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase 2259529 ssuD 7152911 ssuD Escherichia coli IAI39 alkanesulfonate monooxygenase YP_002408175.1 2258384 D 585057 CDS YP_002408176.1 218700547 7152914 2259541..2260332 1 NC_011750.1 part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter permease subunit 2260332 ssuC 7152914 ssuC Escherichia coli IAI39 alkanesulfonate transporter permease subunit YP_002408176.1 2259541 D 585057 CDS YP_002408177.1 218700548 7152913 2260329..2261096 1 NC_011750.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease; aliphatic sulfonates transport ATP-binding subunit 2261096 ssuB 7152913 ssuB Escherichia coli IAI39 aliphatic sulfonates transport ATP-binding subunit YP_002408177.1 2260329 D 585057 CDS YP_002408178.1 218700549 7152912 complement(2261139..2263751) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101837, 86164315, 87163509, 2436977, 3018440; Product type e : enzyme; aminopeptidase N 2263751 pepN 7152912 pepN Escherichia coli IAI39 aminopeptidase N YP_002408178.1 2261139 R 585057 CDS YP_002408179.1 218700550 7152365 2264017..2265219 1 NC_011750.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 2265219 pncB 7152365 pncB Escherichia coli IAI39 nicotinate phosphoribosyltransferase YP_002408179.1 2264017 D 585057 CDS YP_002408180.1 218700551 7152434 2265388..2266788 1 NC_011750.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 2266788 asnC 7152434 asnC Escherichia coli IAI39 asparaginyl-tRNA synthetase YP_002408180.1 2265388 D 585057 CDS YP_002408181.1 218700552 7150805 2267390..2268463 1 NC_011750.1 outer membrane porin F; 1a; Ia; b; outer membrane protein F 2268463 ompF 7150805 ompF Escherichia coli IAI39 outer membrane protein F YP_002408181.1 2267390 D 585057 CDS YP_002408182.1 218700553 7152292 2268648..2269838 1 NC_011750.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 2269838 aspC 7152292 aspC Escherichia coli IAI39 aromatic amino acid aminotransferase YP_002408182.1 2268648 D 585057 CDS YP_002408183.1 218700554 7150807 complement(2269888..2270535) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14529289; Product type pe : putative enzyme; putative metal-binding hydrolase 2270535 ycbL 7150807 ycbL Escherichia coli IAI39 putative metal-binding hydrolase YP_002408183.1 2269888 R 585057 CDS YP_002408184.1 218700555 7153411 complement(2270562..2271110) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2271110 ycbK 7153411 ycbK Escherichia coli IAI39 hypothetical protein YP_002408184.1 2270562 R 585057 CDS YP_002408185.1 218700556 7153410 complement(2271291..2273138) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2273138 ycbB 7153410 ycbB Escherichia coli IAI39 hypothetical protein YP_002408185.1 2271291 R 585057 CDS YP_002408186.1 218700557 7153405 complement(2273399..2277859) 1 NC_011750.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 2277859 mukB 7153405 mukB Escherichia coli IAI39 cell division protein MukB YP_002408186.1 2273399 R 585057 CDS YP_002408187.1 218700558 7152142 complement(2277859..2278536) 1 NC_011750.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 2278536 mukE 7152142 mukE Escherichia coli IAI39 condesin subunit E YP_002408187.1 2277859 R 585057 CDS YP_002408188.1 218700559 7152143 complement(2278544..2279866) 1 NC_011750.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 2279866 mukF 7152143 mukF Escherichia coli IAI39 condesin subunit F YP_002408188.1 2278544 R 585057 CDS YP_002408189.1 218700560 7152144 complement(2279863..2280648) 1 NC_011750.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; putative metallothionein SmtA 2280648 smtA 7152144 smtA Escherichia coli IAI39 putative metallothionein SmtA YP_002408189.1 2279863 R 585057 CDS YP_002408190.1 218700561 7152869 2280784..2281563 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2281563 ycbC 7152869 ycbC Escherichia coli IAI39 hypothetical protein YP_002408190.1 2280784 D 585057 CDS YP_002408191.1 218700562 7153406 complement(2281540..2282433) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2282433 ycbJ 7153406 ycbJ Escherichia coli IAI39 hypothetical protein YP_002408191.1 2281540 R 585057 CDS YP_002408192.1 218700563 7153409 complement(2282587..2283333) 1 NC_011750.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 2283333 kdsB 7153409 kdsB Escherichia coli IAI39 3-deoxy-manno-octulosonate cytidylyltransferase YP_002408192.1 2282587 R 585057 CDS YP_002408193.1 218700564 7151886 complement(2283330..2283512) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2283512 ycaR 7151886 ycaR Escherichia coli IAI39 hypothetical protein YP_002408193.1 2283330 R 585057 CDS YP_002408194.1 218700565 7153404 complement(2283564..2284796) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2284796 ycaQ 7153404 ycaQ Escherichia coli IAI39 hypothetical protein YP_002408194.1 2283564 R 585057 CDS YP_002408195.1 218700566 7153403 complement(2284833..2285819) 1 NC_011750.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 2285819 lpxK 7153403 lpxK Escherichia coli IAI39 tetraacyldisaccharide 4'-kinase YP_002408195.1 2284833 R 585057 CDS YP_002408196.1 218700567 7151970 complement(2285816..2287564) 1 NC_011750.1 involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease 2287564 msbA 7151970 msbA Escherichia coli IAI39 lipid transporter ATP-binding/permease YP_002408196.1 2285816 R 585057 CDS YP_002408197.1 218700568 7152130 complement(2287601..2289865) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2289865 ycaI 7152130 ycaI Escherichia coli IAI39 hypothetical protein YP_002408197.1 2287601 R 585057 CDS YP_002408198.1 218700569 7153395 complement(2290072..2290356) 1 NC_011750.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 2290356 ihfB 7153395 ihfB Escherichia coli IAI39 integration host factor subunit beta YP_002408198.1 2290072 R 585057 CDS YP_002408199.1 218700570 7151761 complement(2290516..2292189) 1 NC_011750.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 2292189 rpsA 7151761 rpsA Escherichia coli IAI39 30S ribosomal protein S1 YP_002408199.1 2290516 R 585057 CDS YP_002408200.1 218700571 7152713 complement(2292300..2292983) 1 NC_011750.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 2292983 cmk 7152713 cmk Escherichia coli IAI39 cytidylate kinase YP_002408200.1 2292300 R 585057 CDS YP_002408201.1 218700572 7150969 complement(2293156..2293920) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative lipoprotein with metallohydrolase domain 2293920 ycaL 7150969 ycaL Escherichia coli IAI39 putative lipoprotein with metallohydrolase domain YP_002408201.1 2293156 R 585057 CDS YP_002408202.1 218700573 7153398 2294109..2295455 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase, IS4 2295455 7153398 ECIAI39_2239 Escherichia coli IAI39 transposase, IS4 YP_002408202.1 2294109 D 585057 CDS YP_002408203.1 218700574 7149957 complement(2295528..2296811) 1 NC_011750.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 2296811 aroA 7149957 aroA Escherichia coli IAI39 3-phosphoshikimate 1-carboxyvinyltransferase YP_002408203.1 2295528 R 585057 CDS YP_002408204.1 218700575 7150775 complement(2296882..2297970) 1 NC_011750.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 2297970 serC 7150775 serC Escherichia coli IAI39 phosphoserine aminotransferase YP_002408204.1 2296882 R 585057 CDS YP_002408205.1 218700576 7152832 complement(2298169..2298861) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2298861 ycaP 7152832 ycaP Escherichia coli IAI39 hypothetical protein YP_002408205.1 2298169 R 585057 CDS YP_002408206.1 218700577 7153402 2298991..2300751 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2300751 ycaO 7153402 ycaO Escherichia coli IAI39 hypothetical protein YP_002408206.1 2298991 D 585057 CDS YP_002408207.1 218700578 7153401 2301157..2302014 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293770, 2651404; Product type t : transporter; formate transporter 2302014 focA 7153401 focA Escherichia coli IAI39 formate transporter YP_002408207.1 2301157 D 585057 CDS YP_002408208.1 218700579 7151395 2302069..2304351 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91064082, 92276323, 10504733, 1310545, 2651404, 3053170, 9629924; Product type e : enzyme; pyruvate formate lyase I 2304351 pflB 7151395 pflB Escherichia coli IAI39 pyruvate formate lyase I YP_002408208.1 2302069 D 585057 CDS YP_002408209.1 218700580 7152373 2304543..2305283 1 NC_011750.1 activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 2305283 pflA 7152373 pflA Escherichia coli IAI39 pyruvate formate lyase-activating enzyme 1 YP_002408209.1 2304543 D 585057 CDS YP_002408210.1 218700581 7152372 complement(2305365..2305955) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3053170; Product type pe : putative enzyme; hypothetical protein 2305955 ycaK 7152372 ycaK Escherichia coli IAI39 hypothetical protein YP_002408210.1 2305365 R 585057 CDS YP_002408211.1 218700582 7153397 2306055..2306963 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2306963 ycaN 7153397 ycaN Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002408211.1 2306055 D 585057 CDS YP_002408212.1 218700583 7153400 complement(2306964..2308394) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type pt : putative transporter; putative transporter 2308394 ycaM 7153400 ycaM Escherichia coli IAI39 putative transporter YP_002408212.1 2306964 R 585057 CDS YP_002408213.1 218700584 7153399 complement(2308604..2309752) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS family transporter protein 2309752 ycaD 7153399 ycaD Escherichia coli IAI39 putative MFS family transporter protein YP_002408213.1 2308604 R 585057 CDS YP_002408214.1 218700585 7153394 2310067..2310693 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9782055, 3062312, 11714269; Product type pe : putative enzyme; putative hydrolase 2310693 ycaC 7153394 ycaC Escherichia coli IAI39 putative hydrolase YP_002408214.1 2310067 D 585057 CDS YP_002408215.1 218700586 7153393 complement(2310728..2311591) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91008971, 92011349, 3062312, 8429002; Product type e : enzyme; dimethyl sulfoxide reductase subunit C 2311591 dmsC 7153393 dmsC Escherichia coli IAI39 dimethyl sulfoxide reductase subunit C YP_002408215.1 2310728 R 585057 CDS YP_002408216.1 218700587 7151151 complement(2311593..2312210) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91070067, 91355180, 92011349, 3062312; Product type e : enzyme; dimethyl sulfoxide reductase subunit B 2312210 dmsB 7151151 dmsB Escherichia coli IAI39 dimethyl sulfoxide reductase subunit B YP_002408216.1 2311593 R 585057 CDS YP_002408217.1 218700588 7151150 complement(2312221..2314665) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91008971, 92011349, 94171715, 10801884, 3062312; Product type e : enzyme; dimethyl sulfoxide reductase subunit A 2314665 dmsA 7151150 dmsA Escherichia coli IAI39 dimethyl sulfoxide reductase subunit A YP_002408217.1 2312221 R 585057 CDS YP_002408218.1 218700589 7151149 complement(2314904..2316196) 1 NC_011750.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 2316196 serS 7151149 serS Escherichia coli IAI39 seryl-tRNA synthetase YP_002408218.1 2314904 R 585057 CDS YP_002408219.1 218700590 7152833 complement(2316287..2317630) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7567469, 7628437, 11459952, 11029431; Product type cp : cell process; recombination factor protein RarA 2317630 ycaJ 7152833 ycaJ Escherichia coli IAI39 recombination factor protein RarA YP_002408219.1 2316287 R 585057 CDS YP_002408220.1 218700591 7153396 complement(2317641..2318255) 1 NC_011750.1 participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 2318255 lolA 7153396 lolA Escherichia coli IAI39 outer-membrane lipoprotein carrier protein YP_002408220.1 2317641 R 585057 CDS YP_002408221.1 218700592 7151950 complement(2318415..2319137) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 2319137 7151950 ECIAI39_2258 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002408221.1 2318415 R 585057 CDS YP_002408222.1 218700593 7149958 complement(2319242..2319772) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 2319772 7149958 ECIAI39_2259 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002408222.1 2319242 R 585057 CDS YP_002408223.1 218700594 7149959 complement(2319847..2323953) 1 NC_011750.1 DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 2323953 ftsK 7149959 ftsK Escherichia coli IAI39 DNA translocase FtsK YP_002408223.1 2319847 R 585057 CDS YP_002408224.1 218700595 7151438 complement(2324088..2324582) 1 NC_011750.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 2324582 lrp 7151438 lrp Escherichia coli IAI39 leucine-responsive transcriptional regulator YP_002408224.1 2324088 R 585057 CDS YP_002408225.1 218700596 7151974 2325127..2326092 1 NC_011750.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase 2326092 trxB 7151974 trxB Escherichia coli IAI39 thioredoxin reductase YP_002408225.1 2325127 D 585057 CDS YP_002408226.1 218700597 7153044 2326215..2327981 1 NC_011750.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 2327981 cydD 7153044 cydD Escherichia coli IAI39 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_002408226.1 2326215 D 585057 CDS YP_002408227.1 218700598 7151045 2327982..2329703 1 NC_011750.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 2329703 cydC 7151045 cydC Escherichia coli IAI39 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_002408227.1 2327982 D 585057 CDS YP_002408228.1 218700599 7151044 2329745..2330449 1 NC_011750.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase 2330449 aat 7151044 aat Escherichia coli IAI39 leucyl/phenylalanyl-tRNA--protein transferase YP_002408228.1 2329745 D 585057 CDS YP_002408229.1 218700600 7150649 2330734..2330952 1 NC_011750.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 2330952 infA 7150649 infA Escherichia coli IAI39 translation initiation factor IF-1 YP_002408229.1 2330734 D 585057 CDS YP_002408230.1 218700601 7150558 2331418..2331822 1 NC_011750.1 hypothetical protein 2331822 7150558 ECIAI39_2267 Escherichia coli IAI39 hypothetical protein YP_002408230.1 2331418 D 585057 CDS YP_002408231.1 218700602 7149960 complement(2331879..2334155) 1 NC_011750.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit 2334155 clpA 7149960 clpA Escherichia coli IAI39 ATP-dependent Clp protease ATP-binding subunit YP_002408231.1 2331879 R 585057 CDS YP_002408232.1 218700603 7150963 complement(2334186..2334506) 1 NC_011750.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 2334506 clpS 7150963 clpS Escherichia coli IAI39 ATP-dependent Clp protease adaptor protein ClpS YP_002408232.1 2334186 R 585057 CDS YP_002408233.1 218700604 7150966 complement(2334605..2334679) 1 NC_011750.1 hypothetical protein 2334679 7150966 ECIAI39_2271 Escherichia coli IAI39 hypothetical protein YP_002408233.1 2334605 R 585057 CDS YP_002408234.1 218700605 7149961 2334829..2335053 1 NC_011750.1 inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD 2335053 cspD 7149961 cspD Escherichia coli IAI39 stationary phase/starvation inducible regulatory protein CspD YP_002408234.1 2334829 D 585057 CDS YP_002408235.1 218700606 7151015 complement(2335126..2337072) 1 NC_011750.1 with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease 2337072 macB 7151015 macB Escherichia coli IAI39 macrolide transporter ATP-binding /permease YP_002408235.1 2335126 R 585057 CDS YP_002408236.1 218700607 7151992 complement(2337069..2338184) 1 NC_011750.1 confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 2338184 macA 7151992 macA Escherichia coli IAI39 macrolide transporter subunit MacA YP_002408236.1 2337069 R 585057 CDS YP_002408237.1 218700608 7151991 2338299..2339291 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2339291 ybjX 7151991 ybjX Escherichia coli IAI39 hypothetical protein YP_002408237.1 2338299 D 585057 CDS YP_002408238.1 218700609 7153391 complement(2339288..2340946) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2340946 ybjD 7153391 ybjD Escherichia coli IAI39 hypothetical protein YP_002408238.1 2339288 R 585057 CDS YP_002408239.1 218700610 7153375 2341372..2342067 1 NC_011750.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z 2342067 aqpZ 7153375 aqpZ Escherichia coli IAI39 aquaporin Z YP_002408239.1 2341372 D 585057 CDS YP_002408240.1 218700611 7150746 complement(2342582..2343607) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase, IS110 family 2343607 7150746 ECIAI39_2278 Escherichia coli IAI39 putative transposase, IS110 family YP_002408240.1 2342582 R 585057 CDS YP_002408241.1 218700612 7149962 complement(2343838..2344785) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566; Product type e : enzyme; tRNA-dihydrouridine synthase C 2344785 dusC 7149962 dusC Escherichia coli IAI39 tRNA-dihydrouridine synthase C YP_002408241.1 2343838 R 585057 CDS YP_002408242.1 218700613 7151187 2345024..2345422 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2345422 yohJ 7151187 yohJ Escherichia coli IAI39 hypothetical protein YP_002408242.1 2345024 D 585057 CDS YP_002408243.1 218700614 7154457 2345419..2346114 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2346114 yohK 7154457 yohK Escherichia coli IAI39 hypothetical protein YP_002408243.1 2345419 D 585057 CDS YP_002408244.1 218700615 7154458 2346244..2347128 1 NC_011750.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2347128 cdd 7154458 cdd Escherichia coli IAI39 cytidine deaminase YP_002408244.1 2346244 D 585057 CDS YP_002408245.1 218700616 7150920 2347278..2347997 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 96125233, 1567863, 8550448; hypothetical protein 2347997 sanA 7150920 sanA Escherichia coli IAI39 hypothetical protein YP_002408245.1 2347278 D 585057 CDS YP_002408246.1 218700617 7152797 2348000..2348239 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2348239 yeiS 7152797 yeiS Escherichia coli IAI39 hypothetical protein YP_002408246.1 2348000 D 585057 CDS YP_002408247.1 218700618 7153782 2348433..2349671 1 NC_011750.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; putative oxidoreductase 2349671 yeiT 7153782 yeiT Escherichia coli IAI39 putative oxidoreductase YP_002408247.1 2348433 D 585057 CDS YP_002408248.1 218700619 7153783 2349665..2350900 1 NC_011750.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines; dihydropyrimidine dehydrogenase 2350900 yeiA 7153783 yeiA Escherichia coli IAI39 dihydropyrimidine dehydrogenase YP_002408248.1 2349665 D 585057 CDS YP_002408249.1 218700620 7153767 complement(2350971..2351981) 1 NC_011750.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane component 2351981 mglC 7153767 mglC Escherichia coli IAI39 beta-methylgalactoside transporter inner membrane component YP_002408249.1 2350971 R 585057 CDS YP_002408250.1 218700621 7152067 complement(2351997..2353517) 1 NC_011750.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein 2353517 mglA 7152067 mglA Escherichia coli IAI39 galactose/methyl galaxtoside transporter ATP-binding protein YP_002408250.1 2351997 R 585057 CDS YP_002408251.1 218700622 7152065 complement(2353578..2354576) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87286407, 92049246, 1719366, 3057628, 3302609, 3600760, 6340108, 6885805, 7012152, 9298646; Product type t : transporter; methyl-galactoside ABC transporter subunit periplasmic-binding protein 2354576 mglB 7152065 mglB Escherichia coli IAI39 methyl-galactoside ABC transporter subunit periplasmic-binding protein YP_002408251.1 2353578 R 585057 CDS YP_002408252.1 218700623 7152066 complement(2354856..2355896) 1 NC_011750.1 negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS 2355896 galS 7152066 galS Escherichia coli IAI39 DNA-binding transcriptional regulator GalS YP_002408252.1 2354856 R 585057 CDS YP_002408253.1 218700624 7151476 complement(2356038..2357195) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2357195 yeiB 7151476 yeiB Escherichia coli IAI39 hypothetical protein YP_002408253.1 2356038 R 585057 CDS YP_002408254.1 218700625 7153768 complement(2357212..2357880) 1 NC_011750.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 2357880 folE 7153768 folE Escherichia coli IAI39 GTP cyclohydrolase I YP_002408254.1 2357212 R 585057 CDS YP_002408255.1 218700626 7151401 2358138..2358974 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16567800; Product type e : enzyme; S-formylglutathione hydrolase 2358974 frmC 7151401 frmC Escherichia coli IAI39 S-formylglutathione hydrolase YP_002408255.1 2358138 D 585057 CDS YP_002408256.1 218700627 7150950 complement(2361271..2362740) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92250419, 94252996, 1315732, 7551055; Product type t : transporter; lysine transporter 2362740 lysP 7150950 lysP Escherichia coli IAI39 lysine transporter YP_002408256.1 2361271 R 585057 CDS YP_002408257.1 218700628 7151984 complement(2362945..2363826) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12400704, 1315732; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2363826 yeiE 7151984 yeiE Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002408257.1 2362945 R 585057 CDS YP_002408258.1 218700629 7153770 2363925..2364974 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2364974 yeiH 7153770 yeiH Escherichia coli IAI39 hypothetical protein YP_002408258.1 2363925 D 585057 CDS YP_002408259.1 218700630 7153771 2365048..2365905 1 NC_011750.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2365905 nfo 7153771 nfo Escherichia coli IAI39 endonuclease IV YP_002408259.1 2365048 D 585057 CDS YP_002408260.1 218700631 7152215 2365908..2366996 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2366996 yeiI 7152215 yeiI Escherichia coli IAI39 hypothetical protein YP_002408260.1 2365908 D 585057 CDS YP_002408261.1 218700632 7153772 complement(2367052..2368302) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sodium/proton nucleoside transporter 2368302 yeiJ 7153772 yeiJ Escherichia coli IAI39 putative sodium/proton nucleoside transporter YP_002408261.1 2367052 R 585057 CDS YP_002408262.1 218700633 7153773 complement(2368402..2369343) 1 NC_011750.1 Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 2369343 rihB 7153773 rihB Escherichia coli IAI39 ribonucleoside hydrolase 2 YP_002408262.1 2368402 R 585057 CDS YP_002408263.1 218700634 7152632 2369512..2370171 1 NC_011750.1 activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 2370171 yeiL 7152632 yeiL Escherichia coli IAI39 DNA-binding transcriptional activator YeiL YP_002408263.1 2369512 D 585057 CDS YP_002408264.1 218700635 7153774 complement(2370239..2371489) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sodium/proton nucleoside transporter 2371489 yeiM 7153774 yeiM Escherichia coli IAI39 putative sodium/proton nucleoside transporter YP_002408264.1 2370239 R 585057 CDS YP_002408265.1 218700636 7153775 complement(2371583..2372521) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2372521 yeiN 7153775 yeiN Escherichia coli IAI39 hypothetical protein YP_002408265.1 2371583 R 585057 CDS YP_002408266.1 218700637 7153777 complement(2372509..2373450) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2373450 yeiC 7153777 yeiC Escherichia coli IAI39 hypothetical protein YP_002408266.1 2372509 R 585057 CDS YP_002408267.1 218700638 7153769 complement(2373874..2375565) 1 NC_011750.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunits IIBC 2375565 fruA 7153769 fruA Escherichia coli IAI39 PTS system fructose-specific transporter subunits IIBC YP_002408267.1 2373874 R 585057 CDS YP_002408268.1 218700639 7151419 complement(2375582..2376520) 1 NC_011750.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase 2376520 fruK 7151419 fruK Escherichia coli IAI39 1-phosphofructokinase YP_002408268.1 2375582 R 585057 CDS YP_002408269.1 218700640 7151421 complement(2376520..2377650) 1 NC_011750.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein 2377650 fruB 7151421 fruB Escherichia coli IAI39 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein YP_002408269.1 2376520 R 585057 CDS YP_002408270.1 218700641 7151420 2378018..2379199 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438463, 10209755; Product type t : transporter; lactose/glucose efflux system 2379199 setB 7151420 setB Escherichia coli IAI39 lactose/glucose efflux system YP_002408270.1 2378018 D 585057 CDS YP_002408271.1 218700642 7152834 complement(2379196..2379450) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2379450 yeiW 7152834 yeiW Escherichia coli IAI39 hypothetical protein YP_002408271.1 2379196 R 585057 CDS YP_002408272.1 218700643 7153785 2379605..2380177 1 NC_011750.1 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 2380177 yeiP 7153785 yeiP Escherichia coli IAI39 elongation factor P YP_002408272.1 2379605 D 585057 CDS YP_002408273.1 218700644 7153779 2380400..2381866 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar dehydrogenase, NAD-dependent 2381866 yeiQ 7153779 yeiQ Escherichia coli IAI39 putative sugar dehydrogenase, NAD-dependent YP_002408273.1 2380400 D 585057 CDS YP_002408274.1 218700645 7153780 2381984..2382970 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2382970 yeiR 7153780 yeiR Escherichia coli IAI39 hypothetical protein YP_002408274.1 2381984 D 585057 CDS YP_002408275.1 218700646 7153781 2383009..2383722 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15778224; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase 2383722 yeiU 7153781 yeiU Escherichia coli IAI39 undecaprenyl pyrophosphate phosphatase YP_002408275.1 2383009 D 585057 CDS YP_002408276.1 218700647 7153784 2384134..2384700 1 NC_011750.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance; putative outer membrane lipoprotein 2384700 spr 7153784 spr Escherichia coli IAI39 putative outer membrane lipoprotein YP_002408276.1 2384134 D 585057 CDS YP_002408277.1 218700648 7152889 2384881..2386437 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2386437 rtn 7152889 rtn Escherichia coli IAI39 hypothetical protein YP_002408277.1 2384881 D 585057 CDS YP_002408278.1 218700649 7152761 2386519..2388333 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide ABC transporter subunit periplasmic-binding protein transporter 2388333 yejA 7152761 yejA Escherichia coli IAI39 putative oligopeptide ABC transporter subunit periplasmic-binding protein transporter YP_002408278.1 2386519 D 585057 CDS YP_002408279.1 218700650 7153786 2388334..2389428 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide ABC transporter permease 2389428 yejB 7153786 yejB Escherichia coli IAI39 putative oligopeptide ABC transporter permease YP_002408279.1 2388334 D 585057 CDS YP_002408280.1 218700651 7153787 2389428..2390453 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide ABC transporter permease 2390453 yejE 7153787 yejE Escherichia coli IAI39 putative oligopeptide ABC transporter permease YP_002408280.1 2389428 D 585057 CDS YP_002408281.1 218700652 7153788 2390455..2392044 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide ABC transporter subunits ATP-binding protein 2392044 yejF 7153788 yejF Escherichia coli IAI39 putative oligopeptide ABC transporter subunits ATP-binding protein YP_002408281.1 2390455 D 585057 CDS YP_002408282.1 218700653 7153789 complement(2392048..2392392) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2392392 yejG 7153789 yejG Escherichia coli IAI39 hypothetical protein YP_002408282.1 2392048 R 585057 CDS YP_002408283.1 218700654 7153790 complement(2392725..2393915) 1 NC_011750.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system 2393915 bcr 7153790 bcr Escherichia coli IAI39 bicyclomycin/multidrug efflux system YP_002408283.1 2392725 R 585057 CDS YP_002408284.1 218700655 7150842 complement(2393943..2394638) 1 NC_011750.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A 2394638 rsuA 7150842 rsuA Escherichia coli IAI39 16S rRNA pseudouridylate synthase A YP_002408284.1 2393943 R 585057 CDS YP_002408285.1 218700656 7152751 2394788..2396548 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleic acid ATP-dependent helicase 2396548 yejH 7152751 yejH Escherichia coli IAI39 putative nucleic acid ATP-dependent helicase YP_002408285.1 2394788 D 585057 CDS YP_002408286.1 218700657 7153791 2396673..2396957 1 NC_011750.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 2396957 rplY 7153791 rplY Escherichia coli IAI39 50S ribosomal protein L25 YP_002408286.1 2396673 D 585057 CDS YP_002408287.1 218700658 7152693 complement(2397096..2398103) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99296598, 10368163; Product type f : factor; nucleoid-associated protein NdpA 2398103 yejK 7152693 yejK Escherichia coli IAI39 nucleoid-associated protein NdpA YP_002408287.1 2397096 R 585057 CDS YP_002408288.1 218700659 7153792 2398285..2398512 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2398512 yejL 7153792 yejL Escherichia coli IAI39 hypothetical protein YP_002408288.1 2398285 D 585057 CDS YP_002408289.1 218700660 7153793 2398532..2400292 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase, inner membrane-associated 2400292 yejM 7153793 yejM Escherichia coli IAI39 putative hydrolase, inner membrane-associated YP_002408289.1 2398532 D 585057 CDS YP_002408290.1 218700661 7150559 complement(2400544..2403054) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15659678; Product type pt : putative transporter; putative autotransporter outer membrane protein; type V secretion 2403054 yejO 7150559 yejO Escherichia coli IAI39 putative autotransporter outer membrane protein; type V secretion YP_002408290.1 2400544 R 585057 CDS YP_002408291.1 218700662 7153795 2403455..2404102 1 NC_011750.1 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 2404102 narP 7153795 narP Escherichia coli IAI39 transcriptional regulator NarP YP_002408291.1 2403455 D 585057 CDS YP_002408292.1 218700663 7152194 complement(2404137..2405189) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 11756453, 12196152, 87260957, 91194558, 95362656, 9914305, 7635817; Product type pe : putative enzyme; heme lyase CcmH 2405189 ccmH 7152194 ccmH Escherichia coli IAI39 heme lyase CcmH YP_002408292.1 2404137 R 585057 CDS YP_002408293.1 218700664 7150918 complement(2405186..2405743) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 9716493, 9770295, 11256948, 11350062, 11843181, 7635817, 9537397; Product type e : enzyme; periplasmic thioredoxin of cytochrome c-type biogenesis 2405743 ccmG 7150918 ccmG Escherichia coli IAI39 periplasmic thioredoxin of cytochrome c-type biogenesis YP_002408293.1 2405186 R 585057 CDS YP_002408294.1 218700665 7150917 complement(2405740..2407683) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 11756453, 12196152, 87260957, 8842153, 91194558, 95362656, 9716493, 7635817; Product type e : enzyme; heme lyase CcmF 2407683 ccmF 7150917 ccmF Escherichia coli IAI39 heme lyase CcmF YP_002408294.1 2405740 R 585057 CDS YP_002408295.1 218700666 7150916 complement(2407680..2408159) 1 NC_011750.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 2408159 ccmE 7150916 ccmE Escherichia coli IAI39 cytochrome c-type biogenesis protein CcmE YP_002408295.1 2407680 R 585057 CDS YP_002408296.1 218700667 7150915 complement(2408156..2408365) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 95362656, 9716493, 7635817; Product type f : factor; cytochrome c biogenesis protein 2408365 ccmD 7150915 ccmD Escherichia coli IAI39 cytochrome c biogenesis protein YP_002408296.1 2408156 R 585057 CDS YP_002408297.1 218700668 7150914 complement(2408362..2409099) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 14532274, 21413853, 95362656, 7635817; Product type t : transporter; heme ABC transporter membrane protein 2409099 ccmC 7150914 ccmC Escherichia coli IAI39 heme ABC transporter membrane protein YP_002408297.1 2408362 R 585057 CDS YP_002408298.1 218700669 7150913 complement(2409141..2409803) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 95362656, 9716493, 7635817; Product type t : transporter; heme ABC transporter membrane protein 2409803 ccmB 7150913 ccmB Escherichia coli IAI39 heme ABC transporter membrane protein YP_002408298.1 2409141 R 585057 CDS YP_002408299.1 218700670 7150912 complement(2409800..2410423) 1 NC_011750.1 ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 2410423 ccmA 7150912 ccmA Escherichia coli IAI39 cytochrome c biogenesis protein CcmA YP_002408299.1 2409800 R 585057 CDS YP_002408300.1 218700671 7150911 complement(2410436..2411038) 1 NC_011750.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC 2411038 napC 7150911 napC Escherichia coli IAI39 cytochrome c-type protein NapC YP_002408300.1 2410436 R 585057 CDS YP_002408301.1 218700672 7152184 complement(2411048..2411497) 1 NC_011750.1 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit 2411497 napB 7152184 napB Escherichia coli IAI39 citrate reductase cytochrome c-type subunit YP_002408301.1 2411048 R 585057 CDS YP_002408302.1 218700673 7152183 complement(2411494..2412357) 1 NC_011750.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component 2412357 napH 7152183 napH Escherichia coli IAI39 quinol dehydrogenase membrane component YP_002408302.1 2411494 R 585057 CDS YP_002408303.1 218700674 7152187 complement(2412344..2413039) 1 NC_011750.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component 2413039 napG 7152187 napG Escherichia coli IAI39 quinol dehydrogenase periplasmic component YP_002408303.1 2412344 R 585057 CDS YP_002408304.1 218700675 7152186 complement(2413046..2415532) 1 NC_011750.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit 2415532 napA 7152186 napA Escherichia coli IAI39 nitrate reductase catalytic subunit YP_002408304.1 2413046 R 585057 CDS YP_002408305.1 218700676 7152182 complement(2415529..2415792) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96228696, 99395037; Product type f : factor; assembly protein for periplasmic nitrate reductase 2415792 napD 7152182 napD Escherichia coli IAI39 assembly protein for periplasmic nitrate reductase YP_002408305.1 2415529 R 585057 CDS YP_002408306.1 218700677 7152185 2416684..2417172 1 NC_011750.1 serine protease inhibitor, inhibits trypsin and other proteases; ecotin 2417172 eco 7152185 eco Escherichia coli IAI39 ecotin YP_002408306.1 2416684 D 585057 CDS YP_002408307.1 218700678 7151199 complement(2417322..2418968) 1 NC_011750.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 2418968 mqo 7151199 mqo Escherichia coli IAI39 malate:quinone oxidoreductase YP_002408307.1 2417322 R 585057 CDS YP_002408308.1 218700679 7152117 complement(2419186..2420829) 1 NC_011750.1 efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane component/ATP-binding protein 2420829 yojI 7152117 yojI Escherichia coli IAI39 multidrug transporter membrane component/ATP-binding protein YP_002408308.1 2419186 R 585057 CDS YP_002408309.1 218700680 7154462 complement(2420905..2421555) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12226668, 12517444, 12862460, 14527653, 87057220, 88151899, 92017669, 3536913, 3887409, 7928996; Product type e : enzyme; N1-methyladenine or N3-methylcytosine DNA lesion oxidative demethylase 2421555 alkB 7154462 alkB Escherichia coli IAI39 N1-methyladenine or N3-methylcytosine DNA lesion oxidative demethylase YP_002408309.1 2420905 R 585057 CDS YP_002408310.1 218700681 7150714 complement(2421555..2422619) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91073391, 93272965, 94252990; Product type r : regulator; fused DNA-binding transcriptional dual regulator ; O6-methylguanine-DNA methyltransferase 2422619 ada 7150714 ada Escherichia coli IAI39 fused DNA-binding transcriptional dual regulator ; O6-methylguanine-DNA methyltransferase YP_002408310.1 2421555 R 585057 CDS YP_002408311.1 218700682 7150682 complement(2422693..2423748) 1 NC_011750.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE 2423748 yojL 7150682 yojL Escherichia coli IAI39 thiamine biosynthesis lipoprotein ApbE YP_002408311.1 2422693 R 585057 CDS YP_002408312.1 218700683 7154463 complement(2423860..2424954) 1 NC_011750.1 allows for ions and hydrophilic solutes to cross the outer membrane; outer membrane porin protein C 2424954 ompC 7154463 ompC Escherichia coli IAI39 outer membrane porin protein C YP_002408312.1 2423860 R 585057 CDS YP_002408313.1 218700684 7152082 complement(2425346..2425510) 1 NC_011750.1 hypothetical protein 2425510 7152082 ECIAI39_2353 Escherichia coli IAI39 hypothetical protein YP_002408313.1 2425346 R 585057 CDS YP_002408314.1 218700685 7149963 2425693..2428365 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11758943, 12864862, 21206231, 2404948, 7984428; Product type r : regulator; phosphotransfer intermediate protein in two-component regulatory system with RcsBC 2428365 rcsD 7149963 rcsD Escherichia coli IAI39 phosphotransfer intermediate protein in two-component regulatory system with RcsBC YP_002408314.1 2425693 D 585057 CDS YP_002408315.1 218700686 7152580 2428382..2429032 1 NC_011750.1 two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 2429032 rcsB 7152580 rcsB Escherichia coli IAI39 transcriptional regulator RcsB YP_002408315.1 2428382 D 585057 CDS YP_002408316.1 218700687 7152578 complement(2429118..2431919) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11758943, 12864862, 14651646, 20032358, 21450811, 88227838, 90130299, 92048476, 9209051, 2404948, 8366025; Product type r : regulator; hybrid sensory kinase in two-component regulatory system with RcsB and YojN 2431919 rcsC 7152578 rcsC Escherichia coli IAI39 hybrid sensory kinase in two-component regulatory system with RcsB and YojN YP_002408316.1 2429118 R 585057 CDS YP_002408317.1 218700688 7152579 2432134..2433960 1 NC_011750.1 with AtoC is a member of a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; sensory histidine kinase AtoS 2433960 atoS 7152579 atoS Escherichia coli IAI39 sensory histidine kinase AtoS YP_002408317.1 2432134 D 585057 CDS YP_002408318.1 218700689 7150820 2433957..2435342 1 NC_011750.1 with AtoS is a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; acetoacetate metabolism regulatory protein AtoC 2435342 atoC 7150820 atoC Escherichia coli IAI39 acetoacetate metabolism regulatory protein AtoC YP_002408318.1 2433957 D 585057 CDS YP_002408319.1 218700690 7150817 2435538..2436200 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73032600, 87083402; Product type c : carrier; acetyl-CoA:acetoacetyl-CoA transferase subunit alpha 2436200 atoD 7150817 atoD Escherichia coli IAI39 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha YP_002408319.1 2435538 D 585057 CDS YP_002408320.1 218700691 7150818 2436200..2436850 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73032600, 87083402; Product type c : carrier; acetyl-CoA:acetoacetyl-CoA transferase subunit beta 2436850 atoA 7150818 atoA Escherichia coli IAI39 acetyl-CoA:acetoacetyl-CoA transferase subunit beta YP_002408320.1 2436200 D 585057 CDS YP_002408321.1 218700692 7150815 2436847..2438169 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73032600, 87083402; Product type t : transporter; short chain fatty acid transporter 2438169 atoE 7150815 atoE Escherichia coli IAI39 short chain fatty acid transporter YP_002408321.1 2436847 D 585057 CDS YP_002408322.1 218700693 7150819 2438200..2439384 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73032600, 87083402; Product type c : carrier; acetyl-CoA acetyltransferase 2439384 atoB 7150819 atoB Escherichia coli IAI39 acetyl-CoA acetyltransferase YP_002408322.1 2438200 D 585057 CDS YP_002408323.1 218700694 7150816 complement(2439458..2440234) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2440234 yfaP 7150816 yfaP Escherichia coli IAI39 hypothetical protein YP_002408323.1 2439458 R 585057 CDS YP_002408324.1 218700695 7153801 complement(2440239..2441888) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2441888 yfaQ 7153801 yfaQ Escherichia coli IAI39 hypothetical protein YP_002408324.1 2440239 R 585057 CDS YP_002408325.1 218700696 7153804 complement(2446427..2447050) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2447050 yfaT 7153804 yfaT Escherichia coli IAI39 hypothetical protein YP_002408325.1 2446427 R 585057 CDS YP_002408326.1 218700697 7153805 complement(2447047..2448735) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2448735 yfaA 7153805 yfaA Escherichia coli IAI39 hypothetical protein YP_002408326.1 2447047 R 585057 CDS YP_002408327.1 218700698 7153796 complement(2448884..2451511) 1 NC_011750.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 2451511 gyrA 7153796 gyrA Escherichia coli IAI39 DNA gyrase subunit A YP_002408327.1 2448884 R 585057 CDS YP_002408328.1 218700699 7151605 complement(2451862..2453076) 1 NC_011750.1 Mandelate racemase/muconate lactonizing enzyme family protein 2453076 7151605 ECIAI39_2370 Escherichia coli IAI39 Mandelate racemase/muconate lactonizing enzyme family protein YP_002408328.1 2451862 R 585057 CDS YP_002408329.1 218700700 7149964 complement(2453077..2454405) 1 NC_011750.1 transporter, major facilitator family 2454405 7149964 ECIAI39_2371 Escherichia coli IAI39 transporter, major facilitator family YP_002408329.1 2453077 R 585057 CDS YP_002408330.1 218700701 7149965 2454643..2455341 1 NC_011750.1 transcriptional regulator, GntR family 2455341 7149965 ECIAI39_2372 Escherichia coli IAI39 transcriptional regulator, GntR family YP_002408330.1 2454643 D 585057 CDS YP_002408331.1 218700702 7149966 2455419..2456141 1 NC_011750.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2456141 ubiG 7149966 ubiG Escherichia coli IAI39 3-demethylubiquinone-9 3-methyltransferase YP_002408331.1 2455419 D 585057 CDS YP_002408332.1 218700703 7153074 complement(2456280..2460044) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659678; Product type f : factor; adhesin 2460044 yfaL 7153074 yfaL Escherichia coli IAI39 adhesin YP_002408332.1 2456280 R 585057 CDS YP_002408333.1 218700704 7153799 2460516..2460659 1 NC_011750.1 hypothetical protein 2460659 7153799 ECIAI39_2375 Escherichia coli IAI39 hypothetical protein YP_002408333.1 2460516 D 585057 CDS YP_002408334.1 218700705 7149967 2460740..2463025 1 NC_011750.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2463025 nrdA 7149967 nrdA Escherichia coli IAI39 ribonucleotide-diphosphate reductase subunit alpha YP_002408334.1 2460740 D 585057 CDS YP_002408335.1 218700706 7152244 2463171..2464301 1 NC_011750.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 2464301 nrdB 7152244 nrdB Escherichia coli IAI39 ribonucleotide-diphosphate reductase subunit beta YP_002408335.1 2463171 D 585057 CDS YP_002408336.1 218700707 7152245 2464301..2464555 1 NC_011750.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin YfaE 2464555 yfaE 7152245 yfaE Escherichia coli IAI39 2Fe-2S ferredoxin YfaE YP_002408336.1 2464301 D 585057 CDS YP_002408337.1 218700708 7153798 complement(2464609..2465259) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 92165728, 1537798, 6087316; hypothetical protein 2465259 inaA 7153798 inaA Escherichia coli IAI39 hypothetical protein YP_002408337.1 2464609 R 585057 CDS YP_002408338.1 218700709 7151776 complement(2465340..2466530) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11206551, 11258796; Product type pt : putative transporter; putative antibiotic efflux protein 2466530 7151776 ECIAI39_2380 Escherichia coli IAI39 putative antibiotic efflux protein YP_002408338.1 2465340 R 585057 CDS YP_002408339.1 218700710 7149968 2466682..2467581 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative transcriptional regulator 2467581 7149968 ECIAI39_2381 Escherichia coli IAI39 putative transcriptional regulator YP_002408339.1 2466682 D 585057 CDS YP_002408340.1 218700711 7149969 complement(2467601..2468677) 1 NC_011750.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase 2468677 glpQ 7149969 glpQ Escherichia coli IAI39 glycerophosphodiester phosphodiesterase YP_002408340.1 2467601 R 585057 CDS YP_002408341.1 218700712 7151544 complement(2468682..2470040) 1 NC_011750.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter 2470040 glpT 7151544 glpT Escherichia coli IAI39 sn-glycerol-3-phosphate transporter YP_002408341.1 2468682 R 585057 CDS YP_002408342.1 218700713 7151546 2470313..2471941 1 NC_011750.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 2471941 glpA 7151546 glpA Escherichia coli IAI39 sn-glycerol-3-phosphate dehydrogenase subunit A YP_002408342.1 2470313 D 585057 CDS YP_002408343.1 218700714 7151536 2471931..2473190 1 NC_011750.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 2473190 glpB 7151536 glpB Escherichia coli IAI39 anaerobic glycerol-3-phosphate dehydrogenase subunit B YP_002408343.1 2471931 D 585057 CDS YP_002408344.1 218700715 7151537 2473187..2474377 1 NC_011750.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 2474377 glpC 7151537 glpC Escherichia coli IAI39 sn-glycerol-3-phosphate dehydrogenase subunit C YP_002408344.1 2473187 D 585057 CDS YP_002408345.1 218700716 7151538 2474570..2475505 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2475505 yfaD 7151538 yfaD Escherichia coli IAI39 hypothetical protein YP_002408345.1 2474570 D 585057 CDS YP_002408346.1 218700717 7153797 2475518..2475703 1 NC_011750.1 Evidence 7 : Gene remnant; putative transposase (fragment) 2475703 ypaA 7153797 ypaA Escherichia coli IAI39 putative transposase (fragment) YP_002408346.1 2475518 D 585057 CDS YP_002408347.1 218700718 7154464 complement(2475744..2476547) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12454498, 16511168, 8550403; Product type pe : putative enzyme; putative aldolase 2476547 yfaU 7154464 yfaU Escherichia coli IAI39 putative aldolase YP_002408347.1 2475744 R 585057 CDS YP_002408348.1 218700719 7153806 complement(2476565..2477854) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative carboxylate transporter; phthalate permease family 2477854 yfaV 7153806 yfaV Escherichia coli IAI39 putative carboxylate transporter; phthalate permease family YP_002408348.1 2476565 R 585057 CDS YP_002408349.1 218700720 7153808 2478696..2479022 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 2479022 7153808 ECIAI39_2392 Escherichia coli IAI39 transposase ORF A, IS629 YP_002408349.1 2478696 D 585057 CDS YP_002408350.1 218700721 7149970 2479019..2479909 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 2479909 7149970 ECIAI39_2393 Escherichia coli IAI39 transposase ORF B, IS629 YP_002408350.1 2479019 D 585057 CDS YP_002408351.1 218700722 7153809 complement(2480444..2481226) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2481226 yfaX 7153809 yfaX Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002408351.1 2480444 R 585057 CDS YP_002408352.1 218700723 7153810 complement(2481446..2482648) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A 2482648 yfaY 7153810 yfaY Escherichia coli IAI39 competence damage-inducible protein A YP_002408352.1 2481446 R 585057 CDS YP_002408353.1 218700724 7153811 complement(2482748..2483290) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane porin protein 2483290 yfaZ 7153811 yfaZ Escherichia coli IAI39 putative outer membrane porin protein YP_002408353.1 2482748 R 585057 CDS YP_002408354.1 218700725 7153812 2483568..2483993 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16430214; Product type pe : putative enzyme; putative NUDIX hydrolase 2483993 yfaO 7153812 yfaO Escherichia coli IAI39 putative NUDIX hydrolase YP_002408354.1 2483568 D 585057 CDS YP_002408355.1 218700726 7153800 complement(2484032..2484634) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2484634 ais 7153800 ais Escherichia coli IAI39 hypothetical protein YP_002408355.1 2484032 R 585057 CDS YP_002408356.1 218700727 7150709 2484924..2486081 1 NC_011750.1 catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 2486081 yfbE 7150709 yfbE Escherichia coli IAI39 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase YP_002408356.1 2484924 D 585057 CDS YP_002408357.1 218700728 7153814 2486085..2487053 1 NC_011750.1 catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 2487053 yfbF 7153814 yfbF Escherichia coli IAI39 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase YP_002408357.1 2486085 D 585057 CDS YP_002408358.1 218700729 7153815 2487053..2489035 1 NC_011750.1 Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 2489035 yfbG 7153815 yfbG Escherichia coli IAI39 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase YP_002408358.1 2487053 D 585057 CDS YP_002408359.1 218700730 7153816 2489032..2489922 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2489922 yfbH 7153816 yfbH Escherichia coli IAI39 hypothetical protein YP_002408359.1 2489032 D 585057 CDS YP_002408360.1 218700731 7153817 2489922..2491574 1 NC_011750.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 2491574 arnT 7153817 arnT Escherichia coli IAI39 4-amino-4-deoxy-L-arabinose transferase YP_002408360.1 2489922 D 585057 CDS YP_002408361.1 218700732 7150774 2491571..2491906 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2491906 yfbW 7150774 yfbW Escherichia coli IAI39 hypothetical protein YP_002408361.1 2491571 D 585057 CDS YP_002408362.1 218700733 7153828 2491906..2492292 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2492292 yfbJ 7153828 yfbJ Escherichia coli IAI39 hypothetical protein YP_002408362.1 2491906 D 585057 CDS YP_002408363.1 218700734 7153818 complement(2492286..2492552) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96015440, 15569938; Product type pt : putative transporter; polymyxin resistance protein B 2492552 pmrD 7153818 pmrD Escherichia coli IAI39 polymyxin resistance protein B YP_002408363.1 2492286 R 585057 CDS YP_002408364.1 218700735 7152432 complement(2492662..2494017) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96186953, 8626063; Product type e : enzyme; O-succinylbenzoic acid--CoA ligase 2494017 menE 7152432 menE Escherichia coli IAI39 O-succinylbenzoic acid--CoA ligase YP_002408364.1 2492662 R 585057 CDS YP_002408365.1 218700736 7152047 complement(2494014..2494976) 1 NC_011750.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 2494976 menC 7152047 menC Escherichia coli IAI39 O-succinylbenzoate synthase YP_002408365.1 2494014 R 585057 CDS YP_002408366.1 218700737 7152045 complement(2494976..2495833) 1 NC_011750.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 2495833 menB 7152045 menB Escherichia coli IAI39 naphthoate synthase YP_002408366.1 2494976 R 585057 CDS YP_002408367.1 218700738 7152044 complement(2495848..2496606) 1 NC_011750.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase YfbB 2496606 yfbB 7152044 yfbB Escherichia coli IAI39 acyl-CoA thioester hydrolase YfbB YP_002408367.1 2495848 R 585057 CDS YP_002408368.1 218700739 7153813 complement(2496603..2498273) 1 NC_011750.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 2498273 menD 7153813 menD Escherichia coli IAI39 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase YP_002408368.1 2496603 R 585057 CDS YP_002408369.1 218700740 7152046 complement(2498362..2499657) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150206, 96140724, 2666397, 7984428, 8549818, 8764478; Product type e : enzyme; isochorismate synthase 2 2499657 menF 7152046 menF Escherichia coli IAI39 isochorismate synthase 2 YP_002408369.1 2498362 R 585057 CDS YP_002408370.1 218700741 7152048 complement(2499736..2500041) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2500041 elaB 7152048 elaB Escherichia coli IAI39 hypothetical protein YP_002408370.1 2499736 R 585057 CDS YP_002408371.1 218700742 7151209 complement(2500089..2500556) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2500556 elaA 7151209 elaA Escherichia coli IAI39 hypothetical protein YP_002408371.1 2500089 R 585057 CDS YP_002408372.1 218700743 7151208 2500621..2501538 1 NC_011750.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2501538 elaC 7151208 elaC Escherichia coli IAI39 ribonuclease Z YP_002408372.1 2500621 D 585057 CDS YP_002408373.1 218700744 7151210 2501729..2502937 1 NC_011750.1 ElaD; specific cysteine protease which targets ubiquitin and ubiquitin-like proteins covalently bound to target proteins; SseL in Salmonella is required for macrophage killing and virulence, and it is secreted by the salmonella pathogenicity island 2 type III secretion system; deubiquitinase 2502937 elaD 7151210 elaD Escherichia coli IAI39 deubiquitinase YP_002408373.1 2501729 D 585057 CDS YP_002408374.1 218700745 7151211 complement(2503008..2504774) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2504774 yfbK 7151211 yfbK Escherichia coli IAI39 hypothetical protein YP_002408374.1 2503008 R 585057 CDS YP_002408375.1 218700746 7153819 complement(2504907..2505410) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 2505410 insB 7153819 insB Escherichia coli IAI39 IS1 transposase InsAB' YP_002408375.1 2504907 R 585057 CDS YP_002408376.1 218700747 7151796 complement(2505329..2505604) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 2505604 insA 7151796 insA Escherichia coli IAI39 IS1 repressor protein InsA YP_002408376.1 2505329 R 585057 CDS YP_002408377.1 218700748 7151785 2505688..2506659 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated peptidase 2506659 yfbL 7151785 yfbL Escherichia coli IAI39 putative membrane-associated peptidase YP_002408377.1 2505688 D 585057 CDS YP_002408378.1 218700749 7153820 2506762..2507265 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2507265 yfbM 7153820 yfbM Escherichia coli IAI39 hypothetical protein YP_002408378.1 2506762 D 585057 CDS YP_002408379.1 218700750 7153821 complement(2507332..2508789) 1 NC_011750.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 2508789 nuoN 7153821 nuoN Escherichia coli IAI39 NADH dehydrogenase subunit N YP_002408379.1 2507332 R 585057 CDS YP_002408380.1 218700751 7152281 complement(2508796..2510325) 1 NC_011750.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 2510325 nuoM 7152281 nuoM Escherichia coli IAI39 NADH dehydrogenase subunit M YP_002408380.1 2508796 R 585057 CDS YP_002408381.1 218700752 7152280 complement(2510491..2512332) 1 NC_011750.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 2512332 nuoL 7152280 nuoL Escherichia coli IAI39 NADH dehydrogenase subunit L YP_002408381.1 2510491 R 585057 CDS YP_002408382.1 218700753 7152279 complement(2512329..2512631) 1 NC_011750.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 2512631 nuoK 7152279 nuoK Escherichia coli IAI39 NADH dehydrogenase subunit K YP_002408382.1 2512329 R 585057 CDS YP_002408383.1 218700754 7152278 complement(2512628..2513182) 1 NC_011750.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 2513182 nuoJ 7152278 nuoJ Escherichia coli IAI39 NADH dehydrogenase subunit J YP_002408383.1 2512628 R 585057 CDS YP_002408384.1 218700755 7152277 complement(2513194..2513736) 1 NC_011750.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 2513736 nuoI 7152277 nuoI Escherichia coli IAI39 NADH dehydrogenase subunit I YP_002408384.1 2513194 R 585057 CDS YP_002408385.1 218700756 7152276 complement(2513751..2514728) 1 NC_011750.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 2514728 nuoH 7152276 nuoH Escherichia coli IAI39 NADH dehydrogenase subunit H YP_002408385.1 2513751 R 585057 CDS YP_002408386.1 218700757 7152275 complement(2514725..2517457) 1 NC_011750.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 2517457 nuoG 7152275 nuoG Escherichia coli IAI39 NADH dehydrogenase subunit G YP_002408386.1 2514725 R 585057 CDS YP_002408387.1 218700758 7152274 complement(2517504..2518841) 1 NC_011750.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F 2518841 nuoF 7152274 nuoF Escherichia coli IAI39 NADH dehydrogenase I subunit F YP_002408387.1 2517504 R 585057 CDS YP_002408388.1 218700759 7152273 complement(2518838..2519338) 1 NC_011750.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 2519338 nuoE 7152273 nuoE Escherichia coli IAI39 NADH dehydrogenase subunit E YP_002408388.1 2518838 R 585057 CDS YP_002408389.1 218700760 7152272 complement(2519341..2521143) 1 NC_011750.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D 2521143 nuoC 7152272 nuoC Escherichia coli IAI39 bifunctional NADH:ubiquinone oxidoreductase subunit C/D YP_002408389.1 2519341 R 585057 CDS YP_002408390.1 218700761 7152271 complement(2521237..2521899) 1 NC_011750.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 2521899 nuoB 7152271 nuoB Escherichia coli IAI39 NADH dehydrogenase subunit B YP_002408390.1 2521237 R 585057 CDS YP_002408391.1 218700762 7152270 complement(2521915..2522358) 1 NC_011750.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 2522358 nuoA 7152270 nuoA Escherichia coli IAI39 NADH dehydrogenase subunit A YP_002408391.1 2521915 R 585057 CDS YP_002408392.1 218700763 7152269 complement(2522988..2523926) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123461, 9882671, 7565112; Product type r : regulator; DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes 2523926 lrhA 7152269 lrhA Escherichia coli IAI39 DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes YP_002408392.1 2522988 R 585057 CDS YP_002408393.1 218700764 7151973 2524846..2526063 1 NC_011750.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 2526063 yfbQ 7151973 yfbQ Escherichia coli IAI39 aminotransferase AlaT YP_002408393.1 2524846 D 585057 CDS YP_002408394.1 218700765 7153822 2526147..2526746 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15489502; Product type e : enzyme; hypothetical protein 2526746 yfbR 7153822 yfbR Escherichia coli IAI39 hypothetical protein YP_002408394.1 2526147 D 585057 CDS YP_002408395.1 218700766 7153823 complement(2526805..2528637) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 2528637 yfbS 7153823 yfbS Escherichia coli IAI39 putative transporter YP_002408395.1 2526805 R 585057 CDS YP_002408396.1 218700767 7153824 complement(2528724..2529374) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphatase 2529374 yfbT 7153824 yfbT Escherichia coli IAI39 putative phosphatase YP_002408396.1 2528724 R 585057 CDS YP_002408397.1 218700768 7153825 complement(2529385..2529879) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2529879 yfbU 7153825 yfbU Escherichia coli IAI39 hypothetical protein YP_002408397.1 2529385 R 585057 CDS YP_002408398.1 218700769 7153826 complement(2529962..2530417) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2530417 yfbV 7153826 yfbV Escherichia coli IAI39 hypothetical protein YP_002408398.1 2529962 R 585057 CDS YP_002408399.1 218700770 7153827 2530755..2531957 1 NC_011750.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2531957 ackA 7153827 ackA Escherichia coli IAI39 acetate kinase YP_002408399.1 2530755 D 585057 CDS YP_002408400.1 218700771 7150665 2532032..2534176 1 NC_011750.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 2534176 pta 7150665 pta Escherichia coli IAI39 phosphate acetyltransferase YP_002408400.1 2532032 D 585057 CDS YP_002408401.1 218700772 7152513 2534366..2535886 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pc : putative carrier; hypothetical protein 2535886 yfcC 7152513 yfcC Escherichia coli IAI39 hypothetical protein YP_002408401.1 2534366 D 585057 CDS YP_002408402.1 218700773 7153830 complement(2535919..2536461) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16430214; Product type pe : putative enzyme; putative NUDIX hydrolase 2536461 yfcD 7153830 yfcD Escherichia coli IAI39 putative NUDIX hydrolase YP_002408402.1 2535919 R 585057 CDS YP_002408403.1 218700774 7153831 complement(2536519..2537073) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; phosphodiesterase 2537073 yfcE 7153831 yfcE Escherichia coli IAI39 phosphodiesterase YP_002408403.1 2536519 R 585057 CDS YP_002408404.1 218700775 7153832 complement(2537126..2537770) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2537770 yfcF 7153832 yfcF Escherichia coli IAI39 hypothetical protein YP_002408404.1 2537126 R 585057 CDS YP_002408405.1 218700776 7153833 2537906..2538553 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; glutathione S-transferase 2538553 yfcG 7153833 yfcG Escherichia coli IAI39 glutathione S-transferase YP_002408405.1 2537906 D 585057 CDS YP_002408406.1 218700777 7153834 2538610..2538972 1 NC_011750.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 2538972 folX 7153834 folX Escherichia coli IAI39 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase YP_002408406.1 2538610 D 585057 CDS YP_002408407.1 218700778 7151405 2538993..2539886 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : putative enzyme; hypothetical protein 2539886 yfcH 7151405 yfcH Escherichia coli IAI39 hypothetical protein YP_002408407.1 2538993 D 585057 CDS YP_002408408.1 218700779 7153835 complement(2539947..2541386) 1 NC_011750.1 hypothetical protein 2541386 7153835 ECIAI39_2452 Escherichia coli IAI39 hypothetical protein YP_002408408.1 2539947 R 585057 CDS YP_002408409.1 218700780 7149979 complement(2541383..2542600) 1 NC_011750.1 cystathionine gamma-synthase 2542600 7149979 ECIAI39_2453 Escherichia coli IAI39 cystathionine gamma-synthase YP_002408409.1 2541383 R 585057 CDS YP_002408410.1 218700781 7149980 complement(2542907..2543809) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase 2543809 yfcI 7149980 yfcI Escherichia coli IAI39 putative transposase YP_002408410.1 2542907 R 585057 CDS YP_002408411.1 218700782 7153836 complement(2544005..2544778) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 3313284, 91060556; Product type t : transporter; histidine/lysine/arginine/ornithine transporter subunit 2544778 hisP 7153836 hisP Escherichia coli IAI39 histidine/lysine/arginine/ornithine transporter subunit YP_002408411.1 2544005 R 585057 CDS YP_002408412.1 218700783 7151657 complement(2544786..2545502) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 3313284; Product type t : transporter; histidine/lysine/arginine/ornithine ABC transporter membrane protein 2545502 hisM 7151657 hisM Escherichia coli IAI39 histidine/lysine/arginine/ornithine ABC transporter membrane protein YP_002408412.1 2544786 R 585057 CDS YP_002408413.1 218700784 7151656 complement(2545499..2546185) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434; Product type t : transporter; histidine/lysine/arginine/ornithine ABC transporter membrane protein 2546185 hisQ 7151656 hisQ Escherichia coli IAI39 histidine/lysine/arginine/ornithine ABC transporter membrane protein YP_002408413.1 2545499 R 585057 CDS YP_002408414.1 218700785 7151658 complement(2546275..2547057) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 6449635, 8161536, 9298646, 9600841, 9740056; Product type t : transporter; histidine/lysine/arginine/ornithine ABC transporter subunit periplasmic-binding protein 2547057 hisJ 7151658 hisJ Escherichia coli IAI39 histidine/lysine/arginine/ornithine ABC transporter subunit periplasmic-binding protein YP_002408414.1 2546275 R 585057 CDS YP_002408415.1 218700786 7151654 complement(2547278..2548060) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4583243, 87308226, 3040734, 9298646; Product type t : transporter; lysine/arginine/ornithine ABC transporter subunit periplasmic-binding protein 2548060 argT 7151654 argT Escherichia coli IAI39 lysine/arginine/ornithine ABC transporter subunit periplasmic-binding protein YP_002408415.1 2547278 R 585057 CDS YP_002408416.1 218700787 7150773 complement(2548326..2548895) 1 NC_011750.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 2548895 ubiX 7150773 ubiX Escherichia coli IAI39 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_002408416.1 2548326 R 585057 CDS YP_002408417.1 218700788 7153076 complement(2548990..2550507) 1 NC_011750.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 2550507 purF 7153076 purF Escherichia coli IAI39 amidophosphoribosyltransferase YP_002408417.1 2548990 R 585057 CDS YP_002408418.1 218700789 7152528 complement(2550544..2551032) 1 NC_011750.1 membrane protein required for colicin V production; colicin V production protein 2551032 cvpA 7152528 cvpA Escherichia coli IAI39 colicin V production protein YP_002408418.1 2550544 R 585057 CDS YP_002408419.1 218700790 7151036 complement(2551362..2552024) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3040734; hypothetical protein 2552024 dedD 7151036 dedD Escherichia coli IAI39 hypothetical protein YP_002408419.1 2551362 R 585057 CDS YP_002408420.1 218700791 7151112 complement(2552014..2553282) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3040739, 91112811, 92041808, 1989505, 3040734; Product type e : enzyme; bifunctional folylpolyglutamate synthase/ dihydrofolate synthase 2553282 folC 7151112 folC Escherichia coli IAI39 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase YP_002408420.1 2552014 R 585057 CDS YP_002408421.1 218700792 7151399 complement(2553352..2554266) 1 NC_011750.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 2554266 accD 7151399 accD Escherichia coli IAI39 acetyl-CoA carboxylase subunit beta YP_002408421.1 2553352 R 585057 CDS YP_002408422.1 218700793 7150659 complement(2554422..2555081) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3029016, 3040734, 7678242; Product type pm : putative membrane component; hypothetical protein 2555081 dedA 7150659 dedA Escherichia coli IAI39 hypothetical protein YP_002408422.1 2554422 R 585057 CDS YP_002408423.1 218700794 7151111 complement(2555164..2555976) 1 NC_011750.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 2555976 truA 7151111 truA Escherichia coli IAI39 tRNA pseudouridine synthase A YP_002408423.1 2555164 R 585057 CDS YP_002408424.1 218700795 7153039 complement(2555976..2556989) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 92380957, 92380982, 93123150, 2681152, 2991861, 3029016; Product type pe : putative enzyme; putative semialdehyde dehydrogenase 2556989 usg 7153039 usg Escherichia coli IAI39 putative semialdehyde dehydrogenase YP_002408424.1 2555976 R 585057 CDS YP_002408425.1 218700796 7153107 complement(2557055..2558191) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90036695, 91035267, 2681152, 2991861, 3029016; Product type e : enzyme; erythronate-4-phosphate dehydrogenase 2558191 pdxB 7153107 pdxB Escherichia coli IAI39 erythronate-4-phosphate dehydrogenase YP_002408425.1 2557055 R 585057 CDS YP_002408426.1 218700797 7152356 2558290..2559285 1 NC_011750.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 2559285 flk 7152356 flk Escherichia coli IAI39 flagella biosynthesis regulator YP_002408426.1 2558290 D 585057 CDS YP_002408427.1 218700798 7151392 complement(2559282..2560460) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 2560460 yfcJ 7151392 yfcJ Escherichia coli IAI39 hypothetical protein YP_002408427.1 2559282 R 585057 CDS YP_002408428.1 218700799 7153837 complement(2560725..2561945) 1 NC_011750.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase I 2561945 fabB 7153837 fabB Escherichia coli IAI39 3-oxoacyl-(acyl carrier protein) synthase I YP_002408428.1 2560725 R 585057 CDS YP_002408429.1 218700800 7151264 2562104..2564110 1 NC_011750.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 2564110 mnmC 7151264 mnmC Escherichia coli IAI39 5-methylaminomethyl-2-thiouridine methyltransferase YP_002408429.1 2562104 D 585057 CDS YP_002408430.1 218700801 7153026 complement(2564166..2564444) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2564444 yfcL 7153026 yfcL Escherichia coli IAI39 hypothetical protein YP_002408430.1 2564166 R 585057 CDS YP_002408431.1 218700802 7153838 complement(2564478..2565026) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2565026 yfcM 7153838 yfcM Escherichia coli IAI39 hypothetical protein YP_002408431.1 2564478 R 585057 CDS YP_002408432.1 218700803 7153839 complement(2565026..2565835) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2565835 yfcA 7153839 yfcA Escherichia coli IAI39 hypothetical protein YP_002408432.1 2565026 R 585057 CDS YP_002408433.1 218700804 7153829 complement(2565835..2566659) 1 NC_011750.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 2566659 mepA 7153829 mepA Escherichia coli IAI39 penicillin-insensitive murein endopeptidase YP_002408433.1 2565835 R 585057 CDS YP_002408434.1 218700805 7152049 complement(2566662..2567747) 1 NC_011750.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 2567747 aroC 7152049 aroC Escherichia coli IAI39 chorismate synthase YP_002408434.1 2566662 R 585057 CDS YP_002408435.1 218700806 7150777 complement(2567782..2568714) 1 NC_011750.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 2568714 prmB 7150777 prmB Escherichia coli IAI39 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_002408435.1 2567782 R 585057 CDS YP_002408436.1 218700807 7152481 2568880..2569431 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2569431 yfcN 7152481 yfcN Escherichia coli IAI39 hypothetical protein YP_002408436.1 2568880 D 585057 CDS YP_002408437.1 218700808 7153840 2569517..2570086 1 NC_011750.1 SMC domain-containing protein (fragment) 2570086 7153840 ECIAI39_2481 Escherichia coli IAI39 SMC domain-containing protein (fragment) YP_002408437.1 2569517 D 585057 CDS YP_002408438.1 218700809 7149981 2570201..2570731 1 NC_011750.1 SMC domain-containing protein (fragment) 2570731 7149981 ECIAI39_2482 Escherichia coli IAI39 SMC domain-containing protein (fragment) YP_002408438.1 2570201 D 585057 CDS YP_002408439.1 218700810 7149982 2570697..2571320 1 NC_011750.1 hypothetical protein 2571320 7149982 ECIAI39_2483 Escherichia coli IAI39 hypothetical protein YP_002408439.1 2570697 D 585057 CDS YP_002408440.1 218700811 7149983 complement(2571369..2572229) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2572229 yfcO 7149983 yfcO Escherichia coli IAI39 hypothetical protein YP_002408440.1 2571369 R 585057 CDS YP_002408441.1 218700812 7153841 complement(2572216..2572746) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative exported fimbrial-like adhesin protein 2572746 yfcP 7153841 yfcP Escherichia coli IAI39 putative exported fimbrial-like adhesin protein YP_002408441.1 2572216 R 585057 CDS YP_002408442.1 218700813 7153842 complement(2572743..2573222) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein 2573222 yfcQ 7153842 yfcQ Escherichia coli IAI39 putative fimbrial-like adhesin exported protein YP_002408442.1 2572743 R 585057 CDS YP_002408443.1 218700814 7153843 complement(2573219..2573788) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein 2573788 yfcR 7153843 yfcR Escherichia coli IAI39 putative fimbrial-like adhesin exported protein YP_002408443.1 2573219 R 585057 CDS YP_002408444.1 218700815 7153844 complement(2573739..2574491) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative periplasmic pilus exported chaperone 2574491 yfcS 7153844 yfcS Escherichia coli IAI39 putative periplasmic pilus exported chaperone YP_002408444.1 2573739 R 585057 CDS YP_002408445.1 218700816 7153845 complement(2574511..2577168) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative export usher protein 2577168 yfcU 7153845 yfcU Escherichia coli IAI39 putative export usher protein YP_002408445.1 2574511 R 585057 CDS YP_002408446.1 218700817 7153846 complement(2577243..2577809) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein 2577809 yfcV 7153846 yfcV Escherichia coli IAI39 putative fimbrial-like adhesin exported protein YP_002408446.1 2577243 R 585057 CDS YP_002408447.1 218700818 7153847 complement(2578329..2578814) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10089421, 20200300, 9489669; Product type e : enzyme; phosphohistidine phosphatase 2578814 sixA 7153847 sixA Escherichia coli IAI39 phosphohistidine phosphatase YP_002408447.1 2578329 R 585057 CDS YP_002408448.1 218700819 7152857 complement(2579017..2581161) 1 NC_011750.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha 2581161 fadJ 7152857 fadJ Escherichia coli IAI39 multifunctional fatty acid oxidation complex subunit alpha YP_002408448.1 2579017 R 585057 CDS YP_002408449.1 218700820 7153848 complement(2581161..2582471) 1 NC_011750.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase 2582471 fadI 7153848 fadI Escherichia coli IAI39 3-ketoacyl-CoA thiolase YP_002408449.1 2581161 R 585057 CDS YP_002408450.1 218700821 7153849 complement(2582652..2582936) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2582936 yfcZ 7153849 yfcZ Escherichia coli IAI39 hypothetical protein YP_002408450.1 2582652 R 585057 CDS YP_002408451.1 218700822 7153850 2583302..2584648 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15178802, 2840553, 3286621, 91100327, 1987139, 9119048; Product type t : transporter; long-chain fatty acid outer membrane transporter 2584648 fadL 7153850 fadL Escherichia coli IAI39 long-chain fatty acid outer membrane transporter YP_002408451.1 2583302 D 585057 CDS YP_002408452.1 218700823 7151277 2585015..2586262 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2586262 yfdF 7151277 yfdF Escherichia coli IAI39 hypothetical protein YP_002408452.1 2585015 D 585057 CDS YP_002408453.1 218700824 7153853 complement(2586441..2587196) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8145644, 15352239; Product type lp : lipoprotein; putative lipoprotein 2587196 vacJ 7153853 vacJ Escherichia coli IAI39 putative lipoprotein YP_002408453.1 2586441 R 585057 CDS YP_002408454.1 218700825 7153125 2587490..2588422 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2588422 yfdC 7153125 yfdC Escherichia coli IAI39 hypothetical protein YP_002408454.1 2587490 D 585057 CDS YP_002408455.1 218700826 7150560 2588734..2589891 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative prophage CPS-53 integrase; CPS-53 (KpLE1) prophage 2589891 intS 7150560 intS Escherichia coli IAI39 putative prophage CPS-53 integrase; CPS-53 (KpLE1) prophage YP_002408455.1 2588734 D 585057 CDS YP_002408456.1 218700827 7151835 2590426..2590752 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 2590752 7151835 ECIAI39_2502 Escherichia coli IAI39 transposase ORF A, IS629 YP_002408456.1 2590426 D 585057 CDS YP_002408457.1 218700828 7149984 2590749..2591639 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 2591639 7149984 ECIAI39_2503 Escherichia coli IAI39 transposase ORF B, IS629 YP_002408457.1 2590749 D 585057 CDS YP_002408458.1 218700829 7149985 complement(2591679..2595179) 1 NC_011750.1 outer membrane autotransporter domain-containing protein (fragment) 2595179 7149985 ECIAI39_2504 Escherichia coli IAI39 outer membrane autotransporter domain-containing protein (fragment) YP_002408458.1 2591679 R 585057 CDS YP_002408459.1 218700830 7149986 complement(2596142..2596771) 1 NC_011750.1 Type 1 fimbriae regulatory protein fimB 2596771 7149986 ECIAI39_2505 Escherichia coli IAI39 Type 1 fimbriae regulatory protein fimB YP_002408459.1 2596142 R 585057 CDS YP_002408460.1 218700831 7149987 2597520..2598089 1 NC_011750.1 Type 1 fimbriae regulatory protein fimB 2598089 7149987 ECIAI39_2506 Escherichia coli IAI39 Type 1 fimbriae regulatory protein fimB YP_002408460.1 2597520 D 585057 CDS YP_002408461.1 218700832 7149988 complement(2598484..2599437) 1 NC_011750.1 regulates the synthesis and expression of the dsdXA operon and dadA gene; DNA-binding transcriptional regulator DsdC 2599437 dsdC 7149988 dsdC Escherichia coli IAI39 DNA-binding transcriptional regulator DsdC YP_002408461.1 2598484 R 585057 CDS YP_002408462.1 218700833 7151178 2599649..2600986 1 NC_011750.1 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; permease DsdX 2600986 dsdX 7151178 dsdX Escherichia coli IAI39 permease DsdX YP_002408462.1 2599649 D 585057 CDS YP_002408463.1 218700834 7151180 2601004..2602335 1 NC_011750.1 catalyzes the formation of pyruvate from serine; D-serine dehydratase 2602335 dsdA 7151180 dsdA Escherichia coli IAI39 D-serine dehydratase YP_002408463.1 2601004 D 585057 CDS YP_002408464.1 218700835 7151176 complement(2602440..2603978) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20378313; Product type pt : putative transporter; putative multidrug efflux system 2603978 emrY 7151176 emrY Escherichia coli IAI39 putative multidrug efflux system YP_002408464.1 2602440 R 585057 CDS YP_002408465.1 218700836 7151218 complement(2603978..2605141) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20378313; Product type t : transporter; EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component 2605141 emrK 7151218 emrK Escherichia coli IAI39 EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component YP_002408465.1 2603978 R 585057 CDS YP_002408466.1 218700837 7151217 2605557..2606171 1 NC_011750.1 response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; DNA-binding transcriptional activator EvgA 2606171 evgA 7151217 evgA Escherichia coli IAI39 DNA-binding transcriptional activator EvgA YP_002408466.1 2605557 D 585057 CDS YP_002408467.1 218700838 7151255 2606176..2609769 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14523115, 93173621, 9501520, 10923791, 1289796, 8125343, 9535079; Product type r : regulator; hybrid sensory histidine kinase in two-component regulatory system with EvgA 2609769 evgS 7151255 evgS Escherichia coli IAI39 hybrid sensory histidine kinase in two-component regulatory system with EvgA YP_002408467.1 2606176 D 585057 CDS YP_002408468.1 218700839 7151256 complement(2609825..2610970) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2610970 yfdE 7151256 yfdE Escherichia coli IAI39 hypothetical protein YP_002408468.1 2609825 R 585057 CDS YP_002408469.1 218700840 7153852 complement(2611044..2611988) 1 NC_011750.1 member of the AEC family of auxin efflux transporters; unknown function; putative transporter YfdV 2611988 yfdV 7153852 yfdV Escherichia coli IAI39 putative transporter YfdV YP_002408469.1 2611044 R 585057 CDS YP_002408470.1 218700841 7153857 complement(2612057..2613751) 1 NC_011750.1 catalyzes the formation of formyl-CoA from oxalyl-CoA; putative oxalyl-CoA decarboxylase 2613751 oxc 7153857 oxc Escherichia coli IAI39 putative oxalyl-CoA decarboxylase YP_002408470.1 2612057 R 585057 CDS YP_002408471.1 218700842 7152314 complement(2613805..2615055) 1 NC_011750.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase 2615055 frc 7152314 frc Escherichia coli IAI39 formyl-coenzyme A transferase YP_002408471.1 2613805 R 585057 CDS YP_002408472.1 218700843 7151407 complement(2615567..2616199) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11157960; hypothetical protein 2616199 yfdX 7151407 yfdX Escherichia coli IAI39 hypothetical protein YP_002408472.1 2615567 R 585057 CDS YP_002408473.1 218700844 7153858 2616495..2616770 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15183873; Product type lp : lipoprotein; putative lipoprotein 2616770 ypdI 7153858 ypdI Escherichia coli IAI39 putative lipoprotein YP_002408473.1 2616495 D 585057 CDS YP_002408474.1 218700845 7154474 complement(2616746..2616892) 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 2616892 7154474 ECIAI39_2520 Escherichia coli IAI39 hypothetical protein YP_002408474.1 2616746 R 585057 CDS YP_002408475.1 218700846 7149989 complement(2616847..2617089) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089; Product type pm : putative membrane component; hypothetical protein 2617089 yfdY 7149989 yfdY Escherichia coli IAI39 hypothetical protein YP_002408475.1 2616847 R 585057 CDS YP_002408476.1 218700847 7153859 2617442..2618362 1 NC_011750.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 2618362 ddg 7153859 ddg Escherichia coli IAI39 lipid A biosynthesis palmitoleoyl acyltransferase YP_002408476.1 2617442 D 585057 CDS YP_002408477.1 218700848 7153015 complement(2618854..2620092) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; aminotransferase 2620092 yfdZ 7153015 yfdZ Escherichia coli IAI39 aminotransferase YP_002408477.1 2618854 R 585057 CDS YP_002408478.1 218700849 7153860 2620469..2622166 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15522865; Product type prc : putative receptor; putative sensory kinase in two-component system with YpdB 2622166 ypdA 7153860 ypdA Escherichia coli IAI39 putative sensory kinase in two-component system with YpdB YP_002408478.1 2620469 D 585057 CDS YP_002408479.1 218700850 7154465 2622163..2622918 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15522865; Product type pr : putative regulator; putative response regulator in two-component system with YpdA 2622918 ypdB 7154465 ypdB Escherichia coli IAI39 putative response regulator in two-component system with YpdA YP_002408479.1 2622163 D 585057 CDS YP_002408480.1 218700851 7154466 2622931..2623788 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding protein 2623788 ypdC 7154466 ypdC Escherichia coli IAI39 putative DNA-binding protein YP_002408480.1 2622931 D 585057 CDS YP_002408481.1 218700852 7154469 complement(2626234..2627271) 1 NC_011750.1 metalloprotein; exoaminopeptidase 2627271 ypdE 7154469 ypdE Escherichia coli IAI39 exoaminopeptidase YP_002408481.1 2626234 R 585057 CDS YP_002408482.1 218700853 7154470 complement(2627271..2628356) 1 NC_011750.1 Xaa-Pro aminopeptidase; limited methionine aminopeptidase; aminopeptidase 2628356 ypdF 7154470 ypdF Escherichia coli IAI39 aminopeptidase YP_002408482.1 2627271 R 585057 CDS YP_002408483.1 218700854 7154471 complement(2628371..2629618) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative enzyme IIC component of PTS 2629618 ypdG 7154471 ypdG Escherichia coli IAI39 putative enzyme IIC component of PTS YP_002408483.1 2628371 R 585057 CDS YP_002408484.1 218700855 7154472 complement(2629640..2629966) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative enzyme IIB component of PTS 2629966 ypdH 7154472 ypdH Escherichia coli IAI39 putative enzyme IIB component of PTS YP_002408484.1 2629640 R 585057 CDS YP_002408485.1 218700856 7154473 complement(2630185..2631150) 1 NC_011750.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase 2631150 glk 7154473 glk Escherichia coli IAI39 glucokinase YP_002408485.1 2630185 R 585057 CDS YP_002408486.1 218700857 7151518 2631354..2632610 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 2632610 yfeO 7151518 yfeO Escherichia coli IAI39 hypothetical protein YP_002408486.1 2631354 D 585057 CDS YP_002408487.1 218700858 7153868 2632725..2633051 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2633051 ypeC 7153868 ypeC Escherichia coli IAI39 hypothetical protein YP_002408487.1 2632725 D 585057 CDS YP_002408488.1 218700859 7154477 2633136..2633666 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 2633666 7154477 ECIAI39_2536 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002408488.1 2633136 D 585057 CDS YP_002408489.1 218700860 7149990 2633771..2634493 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 2634493 7149990 ECIAI39_2537 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002408489.1 2633771 D 585057 CDS YP_002408490.1 218700861 7149991 complement(2634629..2635867) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20177822, 20305051, 10712688, 10844693; Product type t : transporter; manganese transport protein MntH 2635867 mntH 7149991 mntH Escherichia coli IAI39 manganese transport protein MntH YP_002408490.1 2634629 R 585057 CDS YP_002408491.1 218700862 7152093 2636203..2637405 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 374403, 8022285, 7007808, 827549, 4563236, 1512211; Product type t : transporter; nucleoside (except guanosine) transporter 2637405 nupC 7152093 nupC Escherichia coli IAI39 nucleoside (except guanosine) transporter YP_002408491.1 2636203 D 585057 CDS YP_002408492.1 218700863 7152282 complement(2637454..2639643) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase 2639643 yfeA 7152282 yfeA Escherichia coli IAI39 putative diguanylate cyclase YP_002408492.1 2637454 R 585057 CDS YP_002408493.1 218700864 7150614 2640277..2640621 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative nucleic acid-binding transcriptional regulator 2640621 yfeC 7150614 yfeC Escherichia coli IAI39 putative nucleic acid-binding transcriptional regulator YP_002408493.1 2640277 D 585057 CDS YP_002408494.1 218700865 7153862 2640623..2641015 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative nucleic acid-binding transcriptional regulator 2641015 yfeD 7153862 yfeD Escherichia coli IAI39 putative nucleic acid-binding transcriptional regulator YP_002408494.1 2640623 D 585057 CDS YP_002408495.1 218700866 7153529 2642320..2642556 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A (remnant), IS609 2642556 yncK 7153529 yncK Escherichia coli IAI39 transposase ORF A (remnant), IS609 YP_002408495.1 2642320 D 585057 CDS YP_002408496.1 218700867 7154407 complement(2642812..2644227) 1 NC_011750.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 2644227 gltX 7154407 gltX Escherichia coli IAI39 glutamyl-tRNA synthetase YP_002408496.1 2642812 R 585057 CDS YP_002408497.1 218700868 7150566 complement(2645054..2645938) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7559336; Product type r : regulator; DNA-binding transcriptional activator XapR 2645938 xapR 7150566 xapR Escherichia coli IAI39 DNA-binding transcriptional activator XapR YP_002408497.1 2645054 R 585057 CDS YP_002408498.1 218700869 7153174 complement(2646013..2647269) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96032385, 7559336; Product type t : transporter; xanthosine transporter 2647269 xapB 7153174 xapB Escherichia coli IAI39 xanthosine transporter YP_002408498.1 2646013 R 585057 CDS YP_002408499.1 218700870 7153173 complement(2647154..2647354) 1 NC_011750.1 hypothetical protein 2647354 7153173 ECIAI39_2549 Escherichia coli IAI39 hypothetical protein YP_002408499.1 2647154 R 585057 CDS YP_002408500.1 218700871 7149992 complement(2647327..2648160) 1 NC_011750.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 2648160 xapA 7149992 xapA Escherichia coli IAI39 purine nucleoside phosphorylase YP_002408500.1 2647327 R 585057 CDS YP_002408501.1 218700872 7153172 complement(2648389..2649318) 1 NC_011750.1 hypothetical protein 2649318 7153172 ECIAI39_2551 Escherichia coli IAI39 hypothetical protein YP_002408501.1 2648389 R 585057 CDS YP_002408502.1 218700873 7149993 complement(2649373..2650686) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative nucleoside transporter 2650686 7149993 ECIAI39_2552 Escherichia coli IAI39 putative nucleoside transporter YP_002408502.1 2649373 R 585057 CDS YP_002408503.1 218700874 7149994 2650871..2651650 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 2651650 yfeN 7149994 yfeN Escherichia coli IAI39 hypothetical protein YP_002408503.1 2650871 D 585057 CDS YP_002408504.1 218700875 7153867 2651889..2652887 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative sodium/bile acid symporter family (mazG-like) 2652887 yfeH 7153867 yfeH Escherichia coli IAI39 putative sodium/bile acid symporter family (mazG-like) YP_002408504.1 2651889 D 585057 CDS YP_002408505.1 218700876 7153865 complement(2652884..2653102) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2653102 ypeB 7153865 ypeB Escherichia coli IAI39 hypothetical protein YP_002408505.1 2652884 R 585057 CDS YP_002408506.1 218700877 7154476 complement(2653104..2655119) 1 NC_011750.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 2655119 ligA 7154476 ligA Escherichia coli IAI39 NAD-dependent DNA ligase LigA YP_002408506.1 2653104 R 585057 CDS YP_002408507.1 218700878 7151935 complement(2655190..2656176) 1 NC_011750.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA 2656176 zipA 7151935 zipA Escherichia coli IAI39 cell division protein ZipA YP_002408507.1 2655190 R 585057 CDS YP_002408508.1 218700879 7154588 2656418..2657179 1 NC_011750.1 putative role in sulfur assimilation; putative sulfate transport protein CysZ 2657179 cysZ 7154588 cysZ Escherichia coli IAI39 putative sulfate transport protein CysZ YP_002408508.1 2656418 D 585057 CDS YP_002408509.1 218700880 7151072 2657207..2657371 1 NC_011750.1 hypothetical protein 2657371 7151072 ECIAI39_2559 Escherichia coli IAI39 hypothetical protein YP_002408509.1 2657207 D 585057 CDS YP_002408510.1 218700881 7149995 2657364..2658335 1 NC_011750.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 2658335 cysK 7149995 cysK Escherichia coli IAI39 cysteine synthase A YP_002408510.1 2657364 D 585057 CDS YP_002408511.1 218700882 7151064 2658719..2658976 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type t : transporter; PTS system phosphohistidinoprotein-hexose phosphotransferase subunit Hpr 2658976 ptsH 7151064 ptsH Escherichia coli IAI39 PTS system phosphohistidinoprotein-hexose phosphotransferase subunit Hpr YP_002408511.1 2658719 D 585057 CDS YP_002408512.1 218700883 7152519 2659021..2660748 1 NC_011750.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 2660748 ptsI 7152519 ptsI Escherichia coli IAI39 phosphoenolpyruvate-protein phosphotransferase YP_002408512.1 2659021 D 585057 CDS YP_002408513.1 218700884 7152520 2660789..2661298 1 NC_011750.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter subunit 2661298 crr 7152520 crr Escherichia coli IAI39 PTS system glucose-specific transporter subunit YP_002408513.1 2660789 D 585057 CDS YP_002408514.1 218700885 7151001 complement(2661341..2662192) 1 NC_011750.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase 2662192 pdxK 7151001 pdxK Escherichia coli IAI39 pyridoxal kinase YP_002408514.1 2661341 R 585057 CDS YP_002408515.1 218700886 7152359 2662297..2662665 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2662665 yfeK 7152359 yfeK Escherichia coli IAI39 hypothetical protein YP_002408515.1 2662297 D 585057 CDS YP_002408516.1 218700887 7153866 complement(2662668..2663579) 1 NC_011750.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B 2663579 cysM 7153866 cysM Escherichia coli IAI39 cysteine synthase B YP_002408516.1 2662668 R 585057 CDS YP_002408517.1 218700888 7151065 complement(2663713..2664810) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202710, 90264334, 2188958, 7665461; Product type t : transporter; sulfate/thiosulfate transporter subunit 2664810 cysA 7151065 cysA Escherichia coli IAI39 sulfate/thiosulfate transporter subunit YP_002408517.1 2663713 R 585057 CDS YP_002408518.1 218700889 7151055 complement(2664800..2665675) 1 NC_011750.1 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate transporter permease subunit 2665675 cysW 7151055 cysW Escherichia coli IAI39 sulfate/thiosulfate transporter permease subunit YP_002408518.1 2664800 R 585057 CDS YP_002408519.1 218700890 7151071 complement(2665675..2666508) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264334, 2188958; Product type t : transporter; sulfate/thiosulfate transporter subunit 2666508 cysU 7151071 cysU Escherichia coli IAI39 sulfate/thiosulfate transporter subunit YP_002408519.1 2665675 R 585057 CDS YP_002408520.1 218700891 7151070 complement(2666508..2667524) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264335, 2188959, 9298646; Product type t : transporter; thiosulfate transporter subunit 2667524 cysP 7151070 cysP Escherichia coli IAI39 thiosulfate transporter subunit YP_002408520.1 2666508 R 585057 CDS YP_002408521.1 218700892 7151067 complement(2667682..2668473) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 97385354, 2188959, 7984428, 9241368; Product type pe : putative enzyme; short chain dehydrogenase 2668473 ucpA 7151067 ucpA Escherichia coli IAI39 short chain dehydrogenase YP_002408521.1 2667682 R 585057 CDS YP_002408522.1 218700893 7153077 complement(2668602..2669459) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2669459 yfeT 7153077 yfeT Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002408522.1 2668602 R 585057 CDS YP_002408523.1 218700894 7153869 2669623..2670519 1 NC_011750.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid-6-phosphate etherase 2670519 murQ 7153869 murQ Escherichia coli IAI39 N-acetylmuramic acid-6-phosphate etherase YP_002408523.1 2669623 D 585057 CDS YP_002408524.1 218700895 7153870 2670523..2671947 1 NC_011750.1 belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; PTS system N-acetylmuramic acid transporter subunits EIIBC 2671947 murP 7153870 murP Escherichia coli IAI39 PTS system N-acetylmuramic acid transporter subunits EIIBC YP_002408524.1 2670523 D 585057 CDS YP_002408525.1 218700896 7152153 2671952..2673250 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15983044, 15060041; Product type e : enzyme; hypothetical protein 2673250 murQ 7152153 murQ Escherichia coli IAI39 hypothetical protein YP_002408525.1 2671952 D 585057 CDS YP_002408526.1 218700897 7152154 complement(2673308..2674207) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2674207 yfeX 7152154 yfeX Escherichia coli IAI39 hypothetical protein YP_002408526.1 2673308 R 585057 CDS YP_002408527.1 218700898 7153871 complement(2674303..2674878) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12900013, 7764507; hypothetical protein 2674878 yfeY 7153871 yfeY Escherichia coli IAI39 hypothetical protein YP_002408527.1 2674303 R 585057 CDS YP_002408528.1 218700899 7153872 complement(2674939..2675388) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2675388 yfeZ 7153872 yfeZ Escherichia coli IAI39 hypothetical protein YP_002408528.1 2674939 R 585057 CDS YP_002408529.1 218700900 7153873 complement(2675375..2675800) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase 2675800 ypeA 7153873 ypeA Escherichia coli IAI39 putative acetyltransferase YP_002408529.1 2675375 R 585057 CDS YP_002408530.1 218700901 7154475 2676014..2676883 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21348478, 6137479, 87242501, 1903834, 8300522; Product type e : enzyme; N-acetylmuramoyl-l-alanine amidase I 2676883 amiA 7154475 amiA Escherichia coli IAI39 N-acetylmuramoyl-l-alanine amidase I YP_002408530.1 2676014 D 585057 CDS YP_002408531.1 218700902 7150725 2676887..2677786 1 NC_011750.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 2677786 hemF 7150725 hemF Escherichia coli IAI39 coproporphyrinogen III oxidase YP_002408531.1 2676887 D 585057 CDS YP_002408532.1 218700903 7151629 complement(2677792..2678844) 1 NC_011750.1 activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR 2678844 yfeG 7151629 yfeG Escherichia coli IAI39 transcriptional regulator EutR YP_002408532.1 2677792 R 585057 CDS YP_002408533.1 218700904 7153864 complement(2678890..2679390) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10464203; Product type ps : putative structure; putative ethanolaminosome structural protein with putative role in ethanolamine utilization 2679390 yffI 7153864 yffI Escherichia coli IAI39 putative ethanolaminosome structural protein with putative role in ethanolamine utilization YP_002408533.1 2678890 R 585057 CDS YP_002408534.1 218700905 7153876 complement(2679403..2680062) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-related structural protein with putative role in ethanolamine utilization 2680062 eutL 7153876 eutL Escherichia coli IAI39 putative carboxysome-related structural protein with putative role in ethanolamine utilization YP_002408534.1 2679403 R 585057 CDS YP_002408535.1 218700906 7151251 complement(2680072..2680959) 1 NC_011750.1 catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit 2680959 eutC 7151251 eutC Escherichia coli IAI39 ethanolamine ammonia-lyase small subunit YP_002408535.1 2680072 R 585057 CDS YP_002408536.1 218700907 7151244 complement(2682353..2683756) 1 NC_011750.1 ethanolamine utilization protein EutA; reactivating factor for ethanolamine ammonia lyase 2683756 eutA 7151244 eutA Escherichia coli IAI39 reactivating factor for ethanolamine ammonia lyase YP_002408536.1 2682353 R 585057 CDS YP_002408537.1 218700908 7151242 complement(2683753..2684979) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7868611, 10464203; Product type pt : putative transporter; putative ethanolamine transporter 2684979 eutH 7151242 eutH Escherichia coli IAI39 putative ethanolamine transporter YP_002408537.1 2683753 R 585057 CDS YP_002408538.1 218700909 7151248 complement(2685096..2686283) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative alcohol dehydrogenase in ethanolamine utilization; ethanolaminosome 2686283 eutG 7151248 eutG Escherichia coli IAI39 putative alcohol dehydrogenase in ethanolamine utilization; ethanolaminosome YP_002408538.1 2685096 R 585057 CDS YP_002408539.1 218700910 7151247 complement(2686273..2687109) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pf : putative factor; putative chaperonin, ethanolamine utilization protein 2687109 eutJ 7151247 eutJ Escherichia coli IAI39 putative chaperonin, ethanolamine utilization protein YP_002408539.1 2686273 R 585057 CDS YP_002408540.1 218700911 7151250 complement(2687120..2688523) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative aldehyde dehydrogenase, ethanolamine utilization protein 2688523 eutE 7151250 eutE Escherichia coli IAI39 putative aldehyde dehydrogenase, ethanolamine utilization protein YP_002408540.1 2687120 R 585057 CDS YP_002408541.1 218700912 7151246 complement(2688535..2688822) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein 2688822 cchB 7151246 cchB Escherichia coli IAI39 putative carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein YP_002408541.1 2688535 R 585057 CDS YP_002408542.1 218700913 7150910 complement(2688928..2689221) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein 2689221 cchA 7150910 cchA Escherichia coli IAI39 putative carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein YP_002408542.1 2688928 R 585057 CDS YP_002408543.1 218700914 7150909 complement(2689260..2690276) 1 NC_011750.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 2690276 eutD 7150909 eutD Escherichia coli IAI39 phosphotransacetylase YP_002408543.1 2689260 R 585057 CDS YP_002408544.1 218700915 7151249 complement(2690273..2691076) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative cobalamin adenosyltransferase in ethanolamine utilization 2691076 eutT 7151249 eutT Escherichia coli IAI39 putative cobalamin adenosyltransferase in ethanolamine utilization YP_002408544.1 2690273 R 585057 CDS YP_002408545.1 218700916 7151254 complement(2691073..2691774) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10464203; hypothetical protein 2691774 eutQ 7151254 eutQ Escherichia coli IAI39 hypothetical protein YP_002408545.1 2691073 R 585057 CDS YP_002408546.1 218700917 7151253 complement(2691749..2692228) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative nucleoside triphosphate hydrolase domain-containing protein 2692228 eutP 7151253 eutP Escherichia coli IAI39 putative nucleoside triphosphate hydrolase domain-containing protein YP_002408546.1 2691749 R 585057 CDS YP_002408547.1 218700918 7151252 complement(2692241..2692576) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein with putative role in ethanol utilization 2692576 ypfE 7151252 ypfE Escherichia coli IAI39 putative carboxysome-like ethanolaminosome structural protein with putative role in ethanol utilization YP_002408547.1 2692241 R 585057 CDS YP_002408548.1 218700919 7154478 complement(2692869..2695148) 1 NC_011750.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 2695148 maeB 7154478 maeB Escherichia coli IAI39 malic enzyme YP_002408548.1 2692869 R 585057 CDS YP_002408549.1 218700920 7151993 2695437..2696387 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90230300; Product type e : enzyme; transaldolase A 2696387 talA 7151993 talA Escherichia coli IAI39 transaldolase A YP_002408549.1 2695437 D 585057 CDS YP_002408550.1 218700921 7152938 2696407..2698410 1 NC_011750.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2698410 tktB 7152938 tktB Escherichia coli IAI39 transketolase YP_002408550.1 2696407 D 585057 CDS YP_002408551.1 218700922 7152990 complement(2698487..2699530) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2699530 ypfG 7152990 ypfG Escherichia coli IAI39 hypothetical protein YP_002408551.1 2698487 R 585057 CDS YP_002408552.1 218700923 7154479 complement(2699656..2700231) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NUDIX hydrolase 2700231 yffH 7154479 yffH Escherichia coli IAI39 putative NUDIX hydrolase YP_002408552.1 2699656 R 585057 CDS YP_002408553.1 218700924 7153875 complement(2700299..2702278) 1 NC_011750.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); putative oxidoreductase 2702278 aegA 7153875 aegA Escherichia coli IAI39 putative oxidoreductase YP_002408553.1 2700299 R 585057 CDS YP_002408554.1 218700925 7150694 2702484..2704184 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92374842, 1508040, 1528845; Product type r : regulator; nitrate/nitrite sensor protein NarQ 2704184 narQ 7150694 narQ Escherichia coli IAI39 nitrate/nitrite sensor protein NarQ YP_002408554.1 2702484 D 585057 CDS YP_002408555.1 218700926 7152195 2704348..2707461 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12426336, 20158894, 21450803, 79216220, 10692383, 1644752; Product type t : transporter; aminoglycoside/multidrug efflux system 2707461 acrD 7152195 acrD Escherichia coli IAI39 aminoglycoside/multidrug efflux system YP_002408555.1 2704348 D 585057 CDS YP_002408556.1 218700927 7150675 2707548..2707727 1 NC_011750.1 hypothetical protein 2707727 7150675 ECIAI39_2608 Escherichia coli IAI39 hypothetical protein YP_002408556.1 2707548 D 585057 CDS YP_002408557.1 218700928 7149996 2708000..2708356 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2708356 yffB 7149996 yffB Escherichia coli IAI39 hypothetical protein YP_002408557.1 2708000 D 585057 CDS YP_002408558.1 218700929 7153874 2708360..2709487 1 NC_011750.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2709487 dapE 7153874 dapE Escherichia coli IAI39 succinyl-diaminopimelate desuccinylase YP_002408558.1 2708360 D 585057 CDS YP_002408559.1 218700930 7151087 2709515..2709715 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2709715 ypfN 7151087 ypfN Escherichia coli IAI39 hypothetical protein YP_002408559.1 2709515 D 585057 CDS YP_002408560.1 218700931 7154483 complement(2709796..2710494) 1 NC_011750.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YpfH 2710494 ypfH 7154483 ypfH Escherichia coli IAI39 esterase YpfH YP_002408560.1 2709796 R 585057 CDS YP_002408561.1 218700932 7154480 complement(2710568..2712583) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 2712583 ypfI 7154480 ypfI Escherichia coli IAI39 putative hydrolase YP_002408561.1 2710568 R 585057 CDS YP_002408562.1 218700933 7154481 complement(2712598..2713461) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2713461 ypfJ 7154481 ypfJ Escherichia coli IAI39 hypothetical protein YP_002408562.1 2712598 R 585057 CDS YP_002408563.1 218700934 7154482 complement(2713629..2714342) 1 NC_011750.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 2714342 purC 7154482 purC Escherichia coli IAI39 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_002408563.1 2713629 R 585057 CDS YP_002408564.1 218700935 7152525 complement(2714555..2715589) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358331, 1885529, 2120198; Product type lp : lipoprotein; lipoprotein 2715589 nlpB 7152525 nlpB Escherichia coli IAI39 lipoprotein YP_002408564.1 2714555 R 585057 CDS YP_002408565.1 218700936 7152234 complement(2715606..2716484) 1 NC_011750.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 2716484 dapA 7152234 dapA Escherichia coli IAI39 dihydrodipicolinate synthase YP_002408565.1 2715606 R 585057 CDS YP_002408566.1 218700937 7151084 2716630..2717202 1 NC_011750.1 negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 2717202 gcvR 7151084 gcvR Escherichia coli IAI39 glycine cleavage system transcriptional repressor YP_002408566.1 2716630 D 585057 CDS YP_002408567.1 218700938 7151499 2717202..2717672 1 NC_011750.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 2717672 bcp 7151499 bcp Escherichia coli IAI39 thioredoxin-dependent thiol peroxidase YP_002408567.1 2717202 D 585057 CDS YP_002408568.1 218700939 7150841 2717925..2718542 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241, 2016588; Product type c : carrier; hydrogenase 4, 4Fe-4S subunit 2718542 hyfA 7150841 hyfA Escherichia coli IAI39 hydrogenase 4, 4Fe-4S subunit YP_002408568.1 2717925 D 585057 CDS YP_002408569.1 218700940 7151721 2718542..2720560 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4 subunit B 2720560 hyfB 7151721 hyfB Escherichia coli IAI39 hydrogenase 4 subunit B YP_002408569.1 2718542 D 585057 CDS YP_002408570.1 218700941 7151722 2720571..2721518 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4, membrane subunit 2721518 hyfC 7151722 hyfC Escherichia coli IAI39 hydrogenase 4, membrane subunit YP_002408570.1 2720571 D 585057 CDS YP_002408571.1 218700942 7151723 2721535..2722974 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4 subunit D 2722974 hyfD 7151723 hyfD Escherichia coli IAI39 hydrogenase 4 subunit D YP_002408571.1 2721535 D 585057 CDS YP_002408572.1 218700943 7151724 2722986..2723636 1 NC_011750.1 interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 2723636 hyfE 7151724 hyfE Escherichia coli IAI39 hydrogenase 4 membrane subunit YP_002408572.1 2722986 D 585057 CDS YP_002408573.1 218700944 7151725 2723641..2725221 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4 subunit F 2725221 hyfF 7151725 hyfF Escherichia coli IAI39 hydrogenase 4 subunit F YP_002408573.1 2723641 D 585057 CDS YP_002408574.1 218700945 7151726 2725259..2726926 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type c : carrier; hydrogenase 4 subunit 2726926 hyfG 7151726 hyfG Escherichia coli IAI39 hydrogenase 4 subunit YP_002408574.1 2725259 D 585057 CDS YP_002408575.1 218700946 7151727 2726936..2727481 1 NC_011750.1 probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far; hydrogenase 4 subunit H 2727481 hyfH 7151727 hyfH Escherichia coli IAI39 hydrogenase 4 subunit H YP_002408575.1 2726936 D 585057 CDS YP_002408576.1 218700947 7151728 2727478..2728236 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type c : carrier; hydrogenase 4, Fe-S subunit 2728236 hyfI 7151728 hyfI Escherichia coli IAI39 hydrogenase 4, Fe-S subunit YP_002408576.1 2727478 D 585057 CDS YP_002408577.1 218700948 7151729 2728229..2728642 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9387241; Product type pf : putative factor; putative processing element hydrogenase 4 2728642 hyfJ 7151729 hyfJ Escherichia coli IAI39 putative processing element hydrogenase 4 YP_002408577.1 2728229 D 585057 CDS YP_002408578.1 218700949 7151732 2730706..2731554 1 NC_011750.1 inner membrane protein presumed to act as a formate transporter; member of the hyf operon; putative formate transporter 2731554 focB 7151732 focB Escherichia coli IAI39 putative formate transporter YP_002408578.1 2730706 D 585057 CDS YP_002408579.1 218700950 7151396 complement(2731591..2732652) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease 2732652 perM 7151396 perM Escherichia coli IAI39 putative permease YP_002408579.1 2731591 R 585057 CDS YP_002408580.1 218700951 7152369 2732865..2734328 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 2734328 yfgC 7152369 yfgC Escherichia coli IAI39 putative peptidase YP_002408580.1 2732865 D 585057 CDS YP_002408581.1 218700952 7153879 2734349..2734708 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 2734708 yfgD 7153879 yfgD Escherichia coli IAI39 putative oxidoreductase YP_002408581.1 2734349 D 585057 CDS YP_002408582.1 218700953 7153880 complement(2734814..2735560) 1 NC_011750.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor 2735560 hda 7153880 hda Escherichia coli IAI39 DNA replication initiation factor YP_002408582.1 2734814 R 585057 CDS YP_002408583.1 218700954 7151617 complement(2735610..2736899) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8332529, 7721693; Product type t : transporter; uracil transporter 2736899 uraA 7151617 uraA Escherichia coli IAI39 uracil transporter YP_002408583.1 2735610 R 585057 CDS YP_002408584.1 218700955 7153106 complement(2736985..2737611) 1 NC_011750.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 2737611 upp 7153106 upp Escherichia coli IAI39 uracil phosphoribosyltransferase YP_002408584.1 2736985 R 585057 CDS YP_002408585.1 218700956 7153105 2737936..2738973 1 NC_011750.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2738973 purM 7153105 purM Escherichia coli IAI39 phosphoribosylaminoimidazole synthetase YP_002408585.1 2737936 D 585057 CDS YP_002408586.1 218700957 7152532 2738973..2739611 1 NC_011750.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 2739611 purN 7152532 purN Escherichia coli IAI39 phosphoribosylglycinamide formyltransferase YP_002408586.1 2738973 D 585057 CDS YP_002408587.1 218700958 7152533 2739783..2741849 1 NC_011750.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2741849 ppk 7152533 ppk Escherichia coli IAI39 polyphosphate kinase YP_002408587.1 2739783 D 585057 CDS YP_002408588.1 218700959 7152464 2741854..2743395 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93107072, 94025037, 94165003, 8212131, 8380170; Product type e : enzyme; exopolyphosphatase 2743395 ppx 7152464 ppx Escherichia coli IAI39 exopolyphosphatase YP_002408588.1 2741854 D 585057 CDS YP_002408589.1 218700960 7153882 complement(2745859..2746011) 1 NC_011750.1 hypothetical protein 2746011 7153882 ECIAI39_2646 Escherichia coli IAI39 hypothetical protein YP_002408589.1 2745859 R 585057 CDS YP_002408590.1 218700961 7149997 2746531..2747049 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein 2747049 yfgH 7149997 yfgH Escherichia coli IAI39 putative outer membrane lipoprotein YP_002408590.1 2746531 D 585057 CDS YP_002408591.1 218700962 7153884 2747486..2747812 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 2747812 7153884 ECIAI39_2649 Escherichia coli IAI39 transposase ORF A, IS629 YP_002408591.1 2747486 D 585057 CDS YP_002408592.1 218700963 7149998 2747809..2748291 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 2748291 7149998 ECIAI39_2650 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002408592.1 2747809 D 585057 CDS YP_002408593.1 218700964 7149999 2748883..2750406 1 NC_011750.1 Group II intron-encoded reverse transcriptase/maturase 2750406 7149999 ECIAI39_2651 Escherichia coli IAI39 Group II intron-encoded reverse transcriptase/maturase YP_002408593.1 2748883 D 585057 CDS YP_002408594.1 218700965 7150537 2750523..2750969 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 2750969 7150537 ECIAI39_2652 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002408594.1 2750523 D 585057 CDS YP_002408595.1 218700966 7153885 complement(2751408..2751890) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage lysis accessory protein 2751890 7153885 ECIAI39_2654 Escherichia coli IAI39 putative phage lysis accessory protein YP_002408595.1 2751408 R 585057 CDS YP_002408596.1 218700967 7150002 complement(2751887..2752516) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage endolysin 2752516 7150002 ECIAI39_2655 Escherichia coli IAI39 putative phage endolysin YP_002408596.1 2751887 R 585057 CDS YP_002408597.1 218700968 7150003 complement(2752801..2753205) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative integral membrane protein from phage origin 2753205 7150003 ECIAI39_2656 Escherichia coli IAI39 putative integral membrane protein from phage origin YP_002408597.1 2752801 R 585057 CDS YP_002408598.1 218700969 7150004 complement(2753512..2756631) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 16689790; Product type e : enzyme; Endo-alpha-sialidase, phage head protein 2756631 7150004 ECIAI39_2657 Escherichia coli IAI39 Endo-alpha-sialidase, phage head protein YP_002408598.1 2753512 R 585057 CDS YP_002408599.1 218700970 7150005 2756704..2757084 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2757084 7150005 ECIAI39_2658 Escherichia coli IAI39 hypothetical protein YP_002408599.1 2756704 D 585057 CDS YP_002408600.1 218700971 7150006 2757402..2758058 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage anti-repressor protein 2758058 7150006 ECIAI39_2659 Escherichia coli IAI39 putative phage anti-repressor protein YP_002408600.1 2757402 D 585057 CDS YP_002408601.1 218700972 7150007 2758288..2758923 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2758923 7150007 ECIAI39_2660 Escherichia coli IAI39 hypothetical protein YP_002408601.1 2758288 D 585057 CDS YP_002408602.1 218700973 7150008 complement(2759026..2759421) 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2759421 7150008 ECIAI39_2661 Escherichia coli IAI39 hypothetical protein YP_002408602.1 2759026 R 585057 CDS YP_002408603.1 218700974 7150010 2761351..2761677 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 2761677 7150010 ECIAI39_2663 Escherichia coli IAI39 transposase ORF A, IS629 YP_002408603.1 2761351 D 585057 CDS YP_002408604.1 218700975 7150011 2761674..2762564 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 2762564 7150011 ECIAI39_2664 Escherichia coli IAI39 transposase ORF B, IS629 YP_002408604.1 2761674 D 585057 CDS YP_002408605.1 218700976 7150012 complement(2762604..2762960) 1 NC_011750.1 transposase (fragment) 2762960 7150012 ECIAI39_2665 Escherichia coli IAI39 transposase (fragment) YP_002408605.1 2762604 R 585057 CDS YP_002408606.1 218700977 7150013 complement(2762957..2763283) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 2763283 7150013 ECIAI39_2666 Escherichia coli IAI39 transposase ORF A, IS629 YP_002408606.1 2762957 R 585057 CDS YP_002408607.1 218700978 7150015 complement(2764146..2765948) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2765948 7150015 ECIAI39_2668 Escherichia coli IAI39 hypothetical protein YP_002408607.1 2764146 R 585057 CDS YP_002408608.1 218700979 7150016 complement(2765945..2768458) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2768458 7150016 ECIAI39_2669 Escherichia coli IAI39 hypothetical protein YP_002408608.1 2765945 R 585057 CDS YP_002408609.1 218700980 7150017 complement(2768471..2769010) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2769010 7150017 ECIAI39_2670 Escherichia coli IAI39 hypothetical protein YP_002408609.1 2768471 R 585057 CDS YP_002408610.1 218700981 7150018 complement(2769010..2769474) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2769474 7150018 ECIAI39_2671 Escherichia coli IAI39 hypothetical protein YP_002408610.1 2769010 R 585057 CDS YP_002408611.1 218700982 7150019 complement(2769474..2771945) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2771945 7150019 ECIAI39_2672 Escherichia coli IAI39 hypothetical protein YP_002408611.1 2769474 R 585057 CDS YP_002408612.1 218700983 7150020 complement(2771945..2772550) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2772550 7150020 ECIAI39_2673 Escherichia coli IAI39 hypothetical protein YP_002408612.1 2771945 R 585057 CDS YP_002408613.1 218700984 7150021 complement(2772550..2772879) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2772879 7150021 ECIAI39_2674 Escherichia coli IAI39 hypothetical protein YP_002408613.1 2772550 R 585057 CDS YP_002408614.1 218700985 7150022 complement(2772924..2773268) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2773268 7150022 ECIAI39_2675 Escherichia coli IAI39 hypothetical protein YP_002408614.1 2772924 R 585057 CDS YP_002408615.1 218700986 7150023 complement(2773270..2773707) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2773707 7150023 ECIAI39_2676 Escherichia coli IAI39 hypothetical protein YP_002408615.1 2773270 R 585057 CDS YP_002408616.1 218700987 7150024 complement(2773759..2774751) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2774751 7150024 ECIAI39_2677 Escherichia coli IAI39 hypothetical protein YP_002408616.1 2773759 R 585057 CDS YP_002408617.1 218700988 7150025 complement(2774760..2775455) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2775455 7150025 ECIAI39_2678 Escherichia coli IAI39 hypothetical protein YP_002408617.1 2774760 R 585057 CDS YP_002408618.1 218700989 7150026 complement(2775458..2775754) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2775754 7150026 ECIAI39_2679 Escherichia coli IAI39 hypothetical protein YP_002408618.1 2775458 R 585057 CDS YP_002408619.1 218700990 7150027 complement(2775751..2777430) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head-to-tail-joining protein 2777430 7150027 ECIAI39_2680 Escherichia coli IAI39 putative head-to-tail-joining protein YP_002408619.1 2775751 R 585057 CDS YP_002408620.1 218700991 7150028 complement(2777445..2777651) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2777651 7150028 ECIAI39_2681 Escherichia coli IAI39 hypothetical protein YP_002408620.1 2777445 R 585057 CDS YP_002408621.1 218700992 7150029 2777829..2777987 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2777987 7150029 ECIAI39_2682 Escherichia coli IAI39 hypothetical protein YP_002408621.1 2777829 D 585057 CDS YP_002408622.1 218700993 7150567 2778452..2778799 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2778799 7150567 ECIAI39_2683 Escherichia coli IAI39 hypothetical protein YP_002408622.1 2778452 D 585057 CDS YP_002408623.1 218700994 7150031 complement(2778885..2780360) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage terminase, large subunit 2780360 7150031 ECIAI39_2684 Escherichia coli IAI39 putative phage terminase, large subunit YP_002408623.1 2778885 R 585057 CDS YP_002408624.1 218700995 7150032 complement(2780357..2781031) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage terminase, small subunit 2781031 7150032 ECIAI39_2685 Escherichia coli IAI39 putative phage terminase, small subunit YP_002408624.1 2780357 R 585057 CDS YP_002408625.1 218700996 7150033 complement(2781072..2781410) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2781410 7150033 ECIAI39_2686 Escherichia coli IAI39 hypothetical protein YP_002408625.1 2781072 R 585057 CDS YP_002408626.1 218700997 7150034 complement(2781403..2781840) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2781840 7150034 ECIAI39_2687 Escherichia coli IAI39 hypothetical protein YP_002408626.1 2781403 R 585057 CDS YP_002408627.1 218700998 7150035 complement(2781765..2782478) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2782478 7150035 ECIAI39_2688 Escherichia coli IAI39 hypothetical protein YP_002408627.1 2781765 R 585057 CDS YP_002408628.1 218700999 7150036 complement(2782489..2783244) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2783244 7150036 ECIAI39_2689 Escherichia coli IAI39 hypothetical protein YP_002408628.1 2782489 R 585057 CDS YP_002408629.1 218701000 7150037 complement(2783246..2783812) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2783812 7150037 ECIAI39_2690 Escherichia coli IAI39 hypothetical protein YP_002408629.1 2783246 R 585057 CDS YP_002408630.1 218701001 7150038 complement(2783809..2784384) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2784384 7150038 ECIAI39_2691 Escherichia coli IAI39 hypothetical protein YP_002408630.1 2783809 R 585057 CDS YP_002408631.1 218701002 7150039 complement(2784446..2784790) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2784790 7150039 ECIAI39_2692 Escherichia coli IAI39 hypothetical protein YP_002408631.1 2784446 R 585057 CDS YP_002408632.1 218701003 7150040 complement(2784908..2785702) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative replication protein P of bacteriophage 2785702 7150040 ECIAI39_2693 Escherichia coli IAI39 putative replication protein P of bacteriophage YP_002408632.1 2784908 R 585057 CDS YP_002408633.1 218701004 7150041 complement(2785665..2786498) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative primosomal protein from phage 2786498 7150041 ECIAI39_2694 Escherichia coli IAI39 putative primosomal protein from phage YP_002408633.1 2785665 R 585057 CDS YP_002408634.1 218701005 7150042 complement(2786514..2786777) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2786777 7150042 ECIAI39_2695 Escherichia coli IAI39 hypothetical protein YP_002408634.1 2786514 R 585057 CDS YP_002408635.1 218701006 7150043 complement(2786865..2787095) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2787095 7150043 ECIAI39_2696 Escherichia coli IAI39 hypothetical protein YP_002408635.1 2786865 R 585057 CDS YP_002408636.1 218701007 7150044 2787250..2787834 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative transcriptional repressor from phage origin 2787834 7150044 ECIAI39_2697 Escherichia coli IAI39 putative transcriptional repressor from phage origin YP_002408636.1 2787250 D 585057 CDS YP_002408637.1 218701008 7150045 2788128..2788442 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2788442 7150045 ECIAI39_2698 Escherichia coli IAI39 hypothetical protein YP_002408637.1 2788128 D 585057 CDS YP_002408638.1 218701009 7150047 2789230..2790174 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative recombination protein from phage 2790174 7150047 ECIAI39_2700 Escherichia coli IAI39 putative recombination protein from phage YP_002408638.1 2789230 D 585057 CDS YP_002408639.1 218701010 7150048 2790224..2790472 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator from phage origin 2790472 7150048 ECIAI39_2701 Escherichia coli IAI39 putative transcriptional regulator from phage origin YP_002408639.1 2790224 D 585057 CDS YP_002408640.1 218701011 7150049 2790582..2790881 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional activator from phage origin 2790881 7150049 ECIAI39_2702 Escherichia coli IAI39 putative transcriptional activator from phage origin YP_002408640.1 2790582 D 585057 CDS YP_002408641.1 218701012 7150050 2790862..2791524 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative adenine methylase from phage origin 2791524 7150050 ECIAI39_2703 Escherichia coli IAI39 putative adenine methylase from phage origin YP_002408641.1 2790862 D 585057 CDS YP_002408642.1 218701013 7150051 complement(2791719..2792969) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative integrase 2792969 7150051 ECIAI39_2704 Escherichia coli IAI39 putative integrase YP_002408642.1 2791719 R 585057 CDS YP_002408643.1 218701014 7150052 complement(2793162..2794739) 1 NC_011750.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 2794739 guaA 7150052 guaA Escherichia coli IAI39 GMP synthase YP_002408643.1 2793162 R 585057 CDS YP_002408644.1 218701015 7151596 complement(2794808..2796274) 1 NC_011750.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 2796274 guaB 7151596 guaB Escherichia coli IAI39 inosine 5'-monophosphate dehydrogenase YP_002408644.1 2794808 R 585057 CDS YP_002408645.1 218701016 7151597 2796436..2797803 1 NC_011750.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2797803 xseA 7151597 xseA Escherichia coli IAI39 exodeoxyribonuclease VII large subunit YP_002408645.1 2796436 D 585057 CDS YP_002408646.1 218701017 7153182 complement(2797857..2805932) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2805932 7153182 ECIAI39_2708 Escherichia coli IAI39 hypothetical protein YP_002408646.1 2797857 R 585057 CDS YP_002408647.1 218701018 7150053 complement(2806042..2807019) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2807019 7150053 ECIAI39_2709 Escherichia coli IAI39 hypothetical protein YP_002408647.1 2806042 R 585057 CDS YP_002408648.1 218701019 7150054 complement(2807069..2809273) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8500884, 3304658, 12540539; Product type pf : putative factor; putative intimin 2809273 7150054 ECIAI39_2710 Escherichia coli IAI39 putative intimin YP_002408648.1 2807069 R 585057 CDS YP_002408649.1 218701020 7150055 complement(2809453..2809668) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2809668 7150055 ECIAI39_2711 Escherichia coli IAI39 hypothetical protein YP_002408649.1 2809453 R 585057 CDS YP_002408650.1 218701021 7150056 complement(2809731..2811203) 1 NC_011750.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 2811203 engA 7150056 engA Escherichia coli IAI39 GTP-binding protein EngA YP_002408650.1 2809731 R 585057 CDS YP_002408651.1 218701022 7151123 complement(2811321..2812499) 1 NC_011750.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL 2812499 yfgL 7151123 yfgL Escherichia coli IAI39 outer membrane protein assembly complex subunit YfgL YP_002408651.1 2811321 R 585057 CDS YP_002408652.1 218701023 7153886 complement(2812510..2813130) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2813130 yfgM 7153886 yfgM Escherichia coli IAI39 hypothetical protein YP_002408652.1 2812510 R 585057 CDS YP_002408653.1 218701024 7153887 complement(2813148..2814422) 1 NC_011750.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 2814422 hisS 7153887 hisS Escherichia coli IAI39 histidyl-tRNA synthetase YP_002408653.1 2813148 R 585057 CDS YP_002408654.1 218701025 7150538 complement(2814533..2815651) 1 NC_011750.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2815651 ispG 7150538 ispG Escherichia coli IAI39 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_002408654.1 2814533 R 585057 CDS YP_002408655.1 218701026 7151856 complement(2815678..2816688) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; cytoskeletal protein RodZ 2816688 yfgA 7151856 yfgA Escherichia coli IAI39 cytoskeletal protein RodZ YP_002408655.1 2815678 R 585057 CDS YP_002408656.1 218701027 7153877 complement(2816973..2818127) 1 NC_011750.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 2818127 yfgB 7153877 yfgB Escherichia coli IAI39 ribosomal RNA large subunit methyltransferase N YP_002408656.1 2816973 R 585057 CDS YP_002408657.1 218701028 7153878 complement(2818277..2818708) 1 NC_011750.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 2818708 ndk 7153878 ndk Escherichia coli IAI39 nucleoside diphosphate kinase YP_002408657.1 2818277 R 585057 CDS YP_002408658.1 218701029 7152203 complement(2818857..2821169) 1 NC_011750.1 penicillin-insensitive transglycosylase/transpeptidase; penicillin-binding protein 1C 2821169 pbpC 7152203 pbpC Escherichia coli IAI39 penicillin-binding protein 1C YP_002408658.1 2818857 R 585057 CDS YP_002408659.1 218701030 7152349 complement(2821170..2826128) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2826128 yfhM 7152349 yfhM Escherichia coli IAI39 hypothetical protein YP_002408659.1 2821170 R 585057 CDS YP_002408660.1 218701031 7153896 2826335..2827180 1 NC_011750.1 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 2827180 sseA 7153896 sseA Escherichia coli IAI39 3-mercaptopyruvate sulfurtransferase YP_002408660.1 2826335 D 585057 CDS YP_002408661.1 218701032 7152785 complement(2827677..2828453) 1 NC_011750.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB 2828453 sseB 7152785 sseB Escherichia coli IAI39 enhanced serine sensitivity protein SseB YP_002408661.1 2827677 R 585057 CDS YP_002408662.1 218701033 7152904 complement(2828572..2829855) 1 NC_011750.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase B 2829855 pepB 7152904 pepB Escherichia coli IAI39 aminopeptidase B YP_002408662.1 2828572 R 585057 CDS YP_002408663.1 218701034 7152362 complement(2829914..2830114) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10393315; Product type pf : putative factor; hypothetical protein 2830114 yfhJ 7152362 yfhJ Escherichia coli IAI39 hypothetical protein YP_002408663.1 2829914 R 585057 CDS YP_002408664.1 218701035 7153893 complement(2830126..2830461) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10393315, 20013001, 92283811, 94181532, 11551196, 1317854, 4375562, 8300516; Product type c : carrier; [2Fe-2S] ferredoxin 2830461 fdx 7153893 fdx Escherichia coli IAI39 [2Fe-2S] ferredoxin YP_002408664.1 2830126 R 585057 CDS YP_002408665.1 218701036 7151293 complement(2830463..2832313) 1 NC_011750.1 involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 2832313 hscA 7151293 hscA Escherichia coli IAI39 chaperone protein HscA YP_002408665.1 2830463 R 585057 CDS YP_002408666.1 218701037 7151675 complement(2832316..2832846) 1 NC_011750.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB 2832846 hscB 7151675 hscB Escherichia coli IAI39 co-chaperone HscB YP_002408666.1 2832316 R 585057 CDS YP_002408667.1 218701038 7151676 complement(2832942..2833265) 1 NC_011750.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein 2833265 iscA 7151676 iscA Escherichia coli IAI39 iron-sulfur cluster assembly protein YP_002408667.1 2832942 R 585057 CDS YP_002408668.1 218701039 7151846 complement(2833282..2833668) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10393315, 11994302, 15153099; Product type f : factor; scaffold protein 2833668 iscU 7151846 iscU Escherichia coli IAI39 scaffold protein YP_002408668.1 2833282 R 585057 CDS YP_002408669.1 218701040 7151849 complement(2833696..2834910) 1 NC_011750.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 2834910 iscS 7151849 iscS Escherichia coli IAI39 cysteine desulfurase YP_002408669.1 2833696 R 585057 CDS YP_002408670.1 218701041 7151848 complement(2835022..2835510) 1 NC_011750.1 regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR 2835510 iscR 7151848 iscR Escherichia coli IAI39 DNA-binding transcriptional regulator IscR YP_002408670.1 2835022 R 585057 CDS YP_002408671.1 218701042 7151847 complement(2835781..2836521) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10393315; Product type pe : putative enzyme; putative methyltransferase 2836521 yfhQ 7151847 yfhQ Escherichia coli IAI39 putative methyltransferase YP_002408671.1 2835781 R 585057 CDS YP_002408672.1 218701043 7153897 2836640..2837443 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6389495, 90202735, 95095968, 10747806, 2138605, 8002619; Product type e : enzyme; inositol monophosphatase 2837443 suhB 7153897 suhB Escherichia coli IAI39 inositol monophosphatase YP_002408672.1 2836640 D 585057 CDS YP_002408673.1 218701044 7152930 2837561..2838442 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 2838442 yfhR 7152930 yfhR Escherichia coli IAI39 putative peptidase YP_002408673.1 2837561 D 585057 CDS YP_002408674.1 218701045 7153898 2838633..2839913 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95020540, 96154950; Product type cp : cell process; stationary phase inducible protein CsiE 2839913 csiE 7153898 csiE Escherichia coli IAI39 stationary phase inducible protein CsiE YP_002408674.1 2838633 D 585057 CDS YP_002408675.1 218701046 7151010 complement(2839905..2841044) 1 NC_011750.1 putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; putative 3-phenylpropionic acid transporter 2841044 hcaT 7151010 hcaT Escherichia coli IAI39 putative 3-phenylpropionic acid transporter YP_002408675.1 2839905 R 585057 CDS YP_002408676.1 218701047 7151613 complement(2841204..2842094) 1 NC_011750.1 activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional regulator HcaR 2842094 hcaR 7151613 hcaR Escherichia coli IAI39 DNA-binding transcriptional regulator HcaR YP_002408676.1 2841204 R 585057 CDS YP_002408677.1 218701048 7151612 2842230..2843591 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83238171, 87008429, 98269008; Product type e : enzyme; 3-phenylpropionate dioxygenase large subunit alpha 2843591 hcaE 7151612 hcaE Escherichia coli IAI39 3-phenylpropionate dioxygenase large subunit alpha YP_002408677.1 2842230 D 585057 CDS YP_002408678.1 218701049 7151610 2843588..2844106 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83238171, 87008429, 98269008, 9603882; Product type e : enzyme; 3-phenylpropionate dioxygenase subunit beta 2844106 hcaF 7151610 hcaF Escherichia coli IAI39 3-phenylpropionate dioxygenase subunit beta YP_002408678.1 2843588 D 585057 CDS YP_002408679.1 218701050 7151611 2844106..2844426 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98269008, 9603882; Product type pc : putative carrier; 3-phenylpropionate dioxygenase ferredoxin subunit 2844426 hcaC 7151611 hcaC Escherichia coli IAI39 3-phenylpropionate dioxygenase ferredoxin subunit YP_002408679.1 2844106 D 585057 CDS YP_002408680.1 218701051 7151608 2844423..2845235 1 NC_011750.1 Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 2845235 hcaB 7151608 hcaB Escherichia coli IAI39 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase YP_002408680.1 2844423 D 585057 CDS YP_002408681.1 218701052 7151607 2845245..2846447 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98269008, 9603882; Product type e : enzyme; phenylpropionate dioxygenase ferredoxin reductase subunit 2846447 hcaD 7151607 hcaD Escherichia coli IAI39 phenylpropionate dioxygenase ferredoxin reductase subunit YP_002408681.1 2845245 D 585057 CDS YP_002408682.1 218701053 7151609 2846472..2846966 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2846966 yphA 7151609 yphA Escherichia coli IAI39 hypothetical protein YP_002408682.1 2846472 D 585057 CDS YP_002408683.1 218701054 7154484 2847033..2847563 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 2847563 7154484 ECIAI39_2745 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002408683.1 2847033 D 585057 CDS YP_002408684.1 218701055 7150057 2847668..2848390 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 2848390 7150057 ECIAI39_2746 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002408684.1 2847668 D 585057 CDS YP_002408685.1 218701056 7150058 complement(2848450..2849322) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2849322 yphB 7150058 yphB Escherichia coli IAI39 hypothetical protein YP_002408685.1 2848450 R 585057 CDS YP_002408686.1 218701057 7154485 complement(2849334..2850395) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 2850395 yphC 7154485 yphC Escherichia coli IAI39 putative oxidoreductase YP_002408686.1 2849334 R 585057 CDS YP_002408687.1 218701058 7154486 complement(2850461..2851459) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter membrane protein 2851459 yphD 7154486 yphD Escherichia coli IAI39 putative sugar ABC transporter membrane protein YP_002408687.1 2850461 R 585057 CDS YP_002408688.1 218701059 7154487 complement(2851484..2852995) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; sugar ABC transporter ATP-binding protein 2852995 yphE 7154487 yphE Escherichia coli IAI39 sugar ABC transporter ATP-binding protein YP_002408688.1 2851484 R 585057 CDS YP_002408689.1 218701060 7154488 complement(2853018..2854001) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pt : putative transporter; putative sugar ABC transporter periplasmic-binding protein 2854001 yphF 7154488 yphF Escherichia coli IAI39 putative sugar ABC transporter periplasmic-binding protein YP_002408689.1 2853018 R 585057 CDS YP_002408690.1 218701061 7154489 complement(2854098..2857379) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2857379 yphG 7154489 yphG Escherichia coli IAI39 hypothetical protein YP_002408690.1 2854098 R 585057 CDS YP_002408691.1 218701062 7154490 2857497..2858690 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2858690 yphH 7154490 yphH Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002408691.1 2857497 D 585057 CDS YP_002408692.1 218701063 7154491 complement(2858753..2860006) 1 NC_011750.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 2860006 glyA 7154491 glyA Escherichia coli IAI39 serine hydroxymethyltransferase YP_002408692.1 2858753 R 585057 CDS YP_002408693.1 218701064 7151559 complement(2860047..2860223) 1 NC_011750.1 hypothetical protein 2860223 7151559 ECIAI39_2755 Escherichia coli IAI39 hypothetical protein YP_002408693.1 2860047 R 585057 CDS YP_002408694.1 218701065 7150059 2860334..2861524 1 NC_011750.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 2861524 hmp 7150059 hmp Escherichia coli IAI39 nitric oxide dioxygenase YP_002408694.1 2860334 D 585057 CDS YP_002408695.1 218701066 7151662 complement(2861569..2861907) 1 NC_011750.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 2861907 glnB 7151662 glnB Escherichia coli IAI39 nitrogen regulatory protein P-II 1 YP_002408695.1 2861569 R 585057 CDS YP_002408696.1 218701067 7151524 complement(2861968..2863302) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8226691, 8412694; Product type pr : putative regulator; putative DNA-binding response regulator in two-component system 2863302 yfhA 7151524 yfhA Escherichia coli IAI39 putative DNA-binding response regulator in two-component system YP_002408696.1 2861968 R 585057 CDS YP_002408697.1 218701068 7153888 complement(2863292..2864005) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2864005 yfhG 7153888 yfhG Escherichia coli IAI39 hypothetical protein YP_002408697.1 2863292 R 585057 CDS YP_002408698.1 218701069 7153891 complement(2864170..2865597) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative sensory kinase in two-component system 2865597 yfhK 7153891 yfhK Escherichia coli IAI39 putative sensory kinase in two-component system YP_002408698.1 2864170 R 585057 CDS YP_002408699.1 218701070 7152988 complement(2866175..2870062) 1 NC_011750.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 2870062 purL 7152988 purL Escherichia coli IAI39 phosphoribosylformylglycinamidine synthase YP_002408699.1 2866175 R 585057 CDS YP_002408700.1 218701071 7152531 2870458..2871876 1 NC_011750.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; putative transglycosylase 2871876 yfhD 7152531 yfhD Escherichia coli IAI39 putative transglycosylase YP_002408700.1 2870458 D 585057 CDS YP_002408701.1 218701072 7153890 complement(2871873..2872409) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12110595; Product type e : enzyme; tRNA-specific adenosine deaminase 2872409 tadA 7153890 tadA Escherichia coli IAI39 tRNA-specific adenosine deaminase YP_002408701.1 2871873 R 585057 CDS YP_002408702.1 218701073 7152936 complement(2872434..2873069) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2873069 yfhB 7152936 yfhB Escherichia coli IAI39 hypothetical protein YP_002408702.1 2872434 R 585057 CDS YP_002408703.1 218701074 7153889 2873278..2874126 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2874126 yfhH 7153889 yfhH Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002408703.1 2873278 D 585057 CDS YP_002408704.1 218701075 7153892 2874182..2874442 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8765743, 8880900; Product type c : carrier; ferredoxin 2874442 yfhL 7153892 yfhL Escherichia coli IAI39 ferredoxin YP_002408704.1 2874182 D 585057 CDS YP_002408705.1 218701076 7152786 complement(2874713..2874877) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2874877 7152786 ECIAI39_2767 Escherichia coli IAI39 hypothetical protein YP_002408705.1 2874713 R 585057 CDS YP_002408706.1 218701077 7152787 complement(2875138..2875518) 1 NC_011750.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 2875518 acpS 7152787 acpS Escherichia coli IAI39 4'-phosphopantetheinyl transferase YP_002408706.1 2875138 R 585057 CDS YP_002408707.1 218701078 7150670 complement(2875518..2876249) 1 NC_011750.1 involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase 2876249 pdxJ 7150670 pdxJ Escherichia coli IAI39 pyridoxine 5'-phosphate synthase YP_002408707.1 2875518 R 585057 CDS YP_002408708.1 218701079 7152358 complement(2876261..2876989) 1 NC_011750.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 2876989 recO 7152358 recO Escherichia coli IAI39 DNA repair protein RecO YP_002408708.1 2876261 R 585057 CDS YP_002408709.1 218701080 7152595 complement(2877001..2877906) 1 NC_011750.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 2877906 era 7152595 era Escherichia coli IAI39 GTP-binding protein Era YP_002408709.1 2877001 R 585057 CDS YP_002408710.1 218701081 7151238 complement(2877903..2878583) 1 NC_011750.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 2878583 rnc 7151238 rnc Escherichia coli IAI39 ribonuclease III YP_002408710.1 2877903 R 585057 CDS YP_002408711.1 218701082 7150540 complement(2878856..2879830) 1 NC_011750.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I 2879830 lepB 7150540 lepB Escherichia coli IAI39 signal peptidase I YP_002408711.1 2878856 R 585057 CDS YP_002408712.1 218701083 7151923 complement(2879846..2881645) 1 NC_011750.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 2881645 lepA 7151923 lepA Escherichia coli IAI39 GTP-binding protein LepA YP_002408712.1 2879846 R 585057 CDS YP_002408713.1 218701084 7151922 complement(2881843..2882322) 1 NC_011750.1 involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC 2882322 rseC 7151922 rseC Escherichia coli IAI39 SoxR reducing system protein RseC YP_002408713.1 2881843 R 585057 CDS YP_002408714.1 218701085 7152740 complement(2882319..2883275) 1 NC_011750.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE 2883275 rseB 7152740 rseB Escherichia coli IAI39 periplasmic negative regulator of sigmaE YP_002408714.1 2882319 R 585057 CDS YP_002408715.1 218701086 7152739 complement(2883275..2883925) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9159522, 97303092, 99431977, 7768826; Product type f : factor; anti-RNA polymerase sigma factor SigE 2883925 rseA 7152739 rseA Escherichia coli IAI39 anti-RNA polymerase sigma factor SigE YP_002408715.1 2883275 R 585057 CDS YP_002408716.1 218701087 7152738 complement(2883958..2884533) 1 NC_011750.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 2884533 rpoE 7152738 rpoE Escherichia coli IAI39 RNA polymerase sigma factor RpoE YP_002408716.1 2883958 R 585057 CDS YP_002408717.1 218701088 7152707 2884941..2886563 1 NC_011750.1 catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 2886563 nadB 7152707 nadB Escherichia coli IAI39 L-aspartate oxidase YP_002408717.1 2884941 D 585057 CDS YP_002408718.1 218701089 7152166 complement(2886548..2887285) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase 2887285 yfiC 7152166 yfiC Escherichia coli IAI39 putative S-adenosyl-L-methionine-dependent methyltransferase YP_002408718.1 2886548 R 585057 CDS YP_002408719.1 218701090 7153901 2887417..2888751 1 NC_011750.1 facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2888751 srmB 7153901 srmB Escherichia coli IAI39 ATP-dependent RNA helicase SrmB YP_002408719.1 2887417 D 585057 CDS YP_002408720.1 218701091 7152901 2888932..2889462 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 2889462 7152901 ECIAI39_2782 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002408720.1 2888932 D 585057 CDS YP_002408721.1 218701092 7150061 2889567..2890289 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 2890289 7150061 ECIAI39_2783 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002408721.1 2889567 D 585057 CDS YP_002408722.1 218701093 7153904 2891379..2891966 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12562784; Product type t : transporter; neutral amino-acid efflux protein 2891966 yfiK 7153904 yfiK Escherichia coli IAI39 neutral amino-acid efflux protein YP_002408722.1 2891379 D 585057 CDS YP_002408723.1 218701094 7153907 complement(2892021..2892404) 1 NC_011750.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA 2892404 yfiD 7153907 yfiD Escherichia coli IAI39 autonomous glycyl radical cofactor GrcA YP_002408723.1 2892021 R 585057 CDS YP_002408724.1 218701095 7153902 2892709..2893398 1 NC_011750.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2893398 ung 7153902 ung Escherichia coli IAI39 uracil-DNA glycosylase YP_002408724.1 2892709 D 585057 CDS YP_002408725.1 218701096 7153104 complement(2893446..2894483) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase 2894483 yfiF 7153104 yfiF Escherichia coli IAI39 putative methyltransferase YP_002408725.1 2893446 R 585057 CDS YP_002408726.1 218701097 7153905 2894690..2895109 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12952960, 9388228, 99175138, 10644706; Product type c : carrier; thioredoxin 2 2895109 trxC 7153905 trxC Escherichia coli IAI39 thioredoxin 2 YP_002408726.1 2894690 D 585057 CDS YP_002408727.1 218701098 7153045 2895178..2895876 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2895876 yfiP 7153045 yfiP Escherichia coli IAI39 hypothetical protein YP_002408727.1 2895178 D 585057 CDS YP_002408728.1 218701099 7153911 2895908..2898568 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; fused acyl-CoA synthetase: NAD(P)-binding subunit ; ATP-binding subunit 2898568 yfiQ 7153911 yfiQ Escherichia coli IAI39 fused acyl-CoA synthetase: NAD(P)-binding subunit ; ATP-binding subunit YP_002408728.1 2895908 D 585057 CDS YP_002408729.1 218701100 7153912 2898682..2900037 1 NC_011750.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 2900037 pssA 7153912 pssA Escherichia coli IAI39 phosphatidylserine synthase YP_002408729.1 2898682 D 585057 CDS YP_002408730.1 218701101 7152508 2900134..2900406 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2900406 yfiM 7152508 yfiM Escherichia coli IAI39 hypothetical protein YP_002408730.1 2900134 D 585057 CDS YP_002408731.1 218701102 7153908 complement(2900403..2901701) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91219460, 1709493, 2053984, 2118499, 2190187, 8419306; Product type t : transporter; alpha-ketoglutarate transporter 2901701 kgtP 7153908 kgtP Escherichia coli IAI39 alpha-ketoglutarate transporter YP_002408731.1 2900403 R 585057 CDS YP_002408732.1 218701103 7151898 2901760..2901942 1 NC_011750.1 hypothetical protein 2901942 7151898 ECIAI39_2796 Escherichia coli IAI39 hypothetical protein YP_002408732.1 2901760 D 585057 CDS YP_002408733.1 218701104 7149777 complement(2907469..2910042) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14550559, 14640692, 91294166, 93015925, 93388583, 99428468; Product type f : factor; protein disaggregation chaperone 2910042 clpB 7149777 clpB Escherichia coli IAI39 protein disaggregation chaperone YP_002408733.1 2907469 R 585057 CDS YP_002408734.1 218701105 7152788 complement(2910172..2910903) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1906060, 2066329; hypothetical protein 2910903 yfiH 7152788 yfiH Escherichia coli IAI39 hypothetical protein YP_002408734.1 2910172 R 585057 CDS YP_002408735.1 218701106 7153906 complement(2910900..2911880) 1 NC_011750.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D 2911880 rluD 7153906 rluD Escherichia coli IAI39 23S rRNA pseudouridine synthase D YP_002408735.1 2910900 R 585057 CDS YP_002408736.1 218701107 7152644 2912015..2912752 1 NC_011750.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 2912752 yfiO 7152644 yfiO Escherichia coli IAI39 outer membrane protein assembly complex subunit YfiO YP_002408736.1 2912015 D 585057 CDS YP_002408737.1 218701108 7153910 complement(2912802..2914148) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element 2914148 insG 7153910 insG Escherichia coli IAI39 putative IS4 transposase; KpLE2 phage-like element YP_002408737.1 2912802 R 585057 CDS YP_002408738.1 218701109 7151811 2914461..2914802 1 NC_011750.1 associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 2914802 yfiA 7151811 yfiA Escherichia coli IAI39 translation inhibitor protein RaiA YP_002408738.1 2914461 D 585057 CDS YP_002408740.1 218701111 7152389 2915052..2916212 1 NC_011750.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 2916212 pheA 7152389 pheA Escherichia coli IAI39 bifunctional chorismate mutase/prephenate dehydratase YP_002408740.1 2915052 D 585057 CDS YP_002408741.1 218701112 7152388 complement(2916255..2917376) 1 NC_011750.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 2917376 tyrA 7152388 tyrA Escherichia coli IAI39 bifunctional chorismate mutase/prephenate dehydrogenase YP_002408741.1 2916255 R 585057 CDS YP_002408742.1 218701113 7153062 complement(2917387..2918457) 1 NC_011750.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 2918457 aroF 7153062 aroF Escherichia coli IAI39 phospho-2-dehydro-3-deoxyheptonate aldolase YP_002408742.1 2917387 R 585057 CDS YP_002408743.1 218701114 7150780 2918491..2919030 1 NC_011750.1 hypothetical protein 2919030 7150780 ECIAI39_2806 Escherichia coli IAI39 hypothetical protein YP_002408743.1 2918491 D 585057 CDS YP_002408744.1 218701115 7150064 2919180..2919698 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2919698 yfiR 7150064 yfiR Escherichia coli IAI39 hypothetical protein YP_002408744.1 2919180 D 585057 CDS YP_002408745.1 218701116 7153913 2919688..2920914 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; hypothetical protein 2920914 yfiN 7153913 yfiN Escherichia coli IAI39 hypothetical protein YP_002408745.1 2919688 D 585057 CDS YP_002408746.1 218701117 7153909 2920930..2921412 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96032391; Product type pm : putative membrane component; putative outer membrane lipoprotein 2921412 yfiB 7153909 yfiB Escherichia coli IAI39 putative outer membrane lipoprotein YP_002408746.1 2920930 D 585057 CDS YP_002408747.1 218701118 7153900 complement(2921489..2921836) 1 NC_011750.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 2921836 rplS 7153900 rplS Escherichia coli IAI39 50S ribosomal protein L19 YP_002408747.1 2921489 R 585057 CDS YP_002408748.1 218701119 7152687 complement(2921878..2922645) 1 NC_011750.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 2922645 trmD 7152687 trmD Escherichia coli IAI39 tRNA (guanine-N(1)-)-methyltransferase YP_002408748.1 2921878 R 585057 CDS YP_002408749.1 218701120 7153027 complement(2922676..2923224) 1 NC_011750.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 2923224 rimM 7153027 rimM Escherichia coli IAI39 16S rRNA-processing protein RimM YP_002408749.1 2922676 R 585057 CDS YP_002408750.1 218701121 7152637 complement(2923243..2923491) 1 NC_011750.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 2923491 rpsP 7152637 rpsP Escherichia coli IAI39 30S ribosomal protein S16 YP_002408750.1 2923243 R 585057 CDS YP_002408751.1 218701122 7152728 complement(2923628..2924989) 1 NC_011750.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein 2924989 ffh 7152728 ffh Escherichia coli IAI39 signal recognition particle protein YP_002408751.1 2923628 R 585057 CDS YP_002408752.1 218701123 7151310 2925081..2925947 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2925947 ypjD 7151310 ypjD Escherichia coli IAI39 hypothetical protein YP_002408752.1 2925081 D 585057 CDS YP_002408753.1 218701124 7154495 2926058..2927254 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2927254 yfjD 7154495 yfjD Escherichia coli IAI39 hypothetical protein YP_002408753.1 2926058 D 585057 CDS YP_002408754.1 218701125 7153915 complement(2927309..2927902) 1 NC_011750.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 2927902 grpE 7153915 grpE Escherichia coli IAI39 heat shock protein GrpE YP_002408754.1 2927309 R 585057 CDS YP_002408755.1 218701126 7151587 2928026..2928904 1 NC_011750.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 2928904 ppnK 7151587 ppnK Escherichia coli IAI39 inorganic polyphosphate/ATP-NAD kinase YP_002408755.1 2928026 D 585057 CDS YP_002408756.1 218701127 7153914 2928990..2930651 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87259985, 91355307, 95058623, 3037486; Product type cp : cell process; recombination and repair protein 2930651 recN 7153914 recN Escherichia coli IAI39 recombination and repair protein YP_002408756.1 2928990 D 585057 CDS YP_002408757.1 218701128 7152594 2930800..2931141 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2045357; Product type lp : lipoprotein; hypothetical protein 2931141 smpA 7152594 smpA Escherichia coli IAI39 hypothetical protein YP_002408757.1 2930800 D 585057 CDS YP_002408758.1 218701129 7152867 complement(2931203..2931493) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2931493 yfjF 7152867 yfjF Escherichia coli IAI39 hypothetical protein YP_002408758.1 2931203 R 585057 CDS YP_002408759.1 218701130 7153916 complement(2931483..2931959) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2931959 yfjG 7153916 yfjG Escherichia coli IAI39 hypothetical protein YP_002408759.1 2931483 R 585057 CDS YP_002408760.1 218701131 7153917 2932091..2932573 1 NC_011750.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 2932573 smpB 7153917 smpB Escherichia coli IAI39 SsrA-binding protein YP_002408760.1 2932091 D 585057 CDS YP_002408761.1 218701132 7152908 2933379..2934593 1 NC_011750.1 Type-2 restriction enzyme EcoRII (R.EcoRII) (Type II restriction enzyme EcoRII) (Endonuclease EcoRII) 2934593 7152908 ECIAI39_2824 Escherichia coli IAI39 Type-2 restriction enzyme EcoRII (R.EcoRII) (Type II restriction enzyme EcoRII) (Endonuclease EcoRII) YP_002408761.1 2933379 D 585057 CDS YP_002408762.1 218701133 7150065 complement(2934628..2936103) 1 NC_011750.1 DNA cytosine methylase 2936103 7150065 ECIAI39_2825 Escherichia coli IAI39 DNA cytosine methylase YP_002408762.1 2934628 R 585057 CDS YP_002408763.1 218701134 7150066 2936413..2937237 1 NC_011750.1 hypothetical protein 2937237 7150066 ECIAI39_2826 Escherichia coli IAI39 hypothetical protein YP_002408763.1 2936413 D 585057 CDS YP_002408764.1 218701135 7150067 complement(2938106..2938267) 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 2938267 7150067 ECIAI39_2827 Escherichia coli IAI39 hypothetical protein YP_002408764.1 2938106 R 585057 CDS YP_002408765.1 218701136 7150068 complement(2938704..2939114) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber assembly protein (possibly partial) 2939114 7150068 ECIAI39_2828 Escherichia coli IAI39 putative tail fiber assembly protein (possibly partial) YP_002408765.1 2938704 R 585057 CDS YP_002408766.1 218701137 7150069 complement(2939099..2940049) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2940049 7150069 ECIAI39_2829 Escherichia coli IAI39 hypothetical protein YP_002408766.1 2939099 R 585057 CDS YP_002408767.1 218701138 7150070 complement(2940053..2940637) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2940637 ymfQ 7150070 ymfQ Escherichia coli IAI39 hypothetical protein YP_002408767.1 2940053 R 585057 CDS YP_002408768.1 218701139 7154391 complement(2940628..2941686) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative baseplate J-like phage protein 2941686 7154391 ECIAI39_2831 Escherichia coli IAI39 putative baseplate J-like phage protein YP_002408768.1 2940628 R 585057 CDS YP_002408769.1 218701140 7150071 complement(2941673..2942101) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail protein 2942101 7150071 ECIAI39_2832 Escherichia coli IAI39 putative tail protein YP_002408769.1 2941673 R 585057 CDS YP_002408770.1 218701141 7150072 complement(2942098..2942646) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative baseplate assembly phage protein 2942646 7150072 ECIAI39_2833 Escherichia coli IAI39 putative baseplate assembly phage protein YP_002408770.1 2942098 R 585057 CDS YP_002408771.1 218701142 7150073 complement(2942646..2943725) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail protein 2943725 7150073 ECIAI39_2834 Escherichia coli IAI39 tail protein YP_002408771.1 2942646 R 585057 CDS YP_002408772.1 218701143 7150074 complement(2943722..2945092) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail/DNA circulation protein 2945092 7150074 ECIAI39_2835 Escherichia coli IAI39 tail/DNA circulation protein YP_002408772.1 2943722 R 585057 CDS YP_002408773.1 218701144 7150075 complement(2945111..2946016) 1 NC_011750.1 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; tail protein from Bacteriophage (fragment) 2946016 7150075 ECIAI39_2836 Escherichia coli IAI39 tail protein from Bacteriophage (fragment) YP_002408773.1 2945111 R 585057 CDS YP_002408774.1 218701145 7150076 complement(2945982..2946872) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 2946872 7150076 ECIAI39_2837 Escherichia coli IAI39 transposase ORF B, IS629 YP_002408774.1 2945982 R 585057 CDS YP_002408775.1 218701146 7150077 complement(2946869..2947195) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 2947195 7150077 ECIAI39_2838 Escherichia coli IAI39 transposase ORF A, IS629 YP_002408775.1 2946869 R 585057 CDS YP_002408776.1 218701147 7154492 complement(2949057..2949323) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative invertase fragment (fragment) 2949323 pinH 7154492 pinH Escherichia coli IAI39 putative invertase fragment (fragment) YP_002408776.1 2949057 R 585057 CDS YP_002408777.1 218701148 7154494 complement(2951630..2951959) 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 2951959 7154494 ECIAI39_2843 Escherichia coli IAI39 hypothetical protein YP_002408777.1 2951630 R 585057 CDS YP_002408778.1 218701149 7150612 2952498..2954750 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative alpha-amylase 2954750 7150612 ECIAI39_2844 Escherichia coli IAI39 putative alpha-amylase YP_002408778.1 2952498 D 585057 CDS YP_002408779.1 218701150 7150080 2955087..2956064 1 NC_011750.1 in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 2956064 ygaT 7150080 ygaT Escherichia coli IAI39 hypothetical protein YP_002408779.1 2955087 D 585057 CDS YP_002408780.1 218701151 7153924 2956084..2957352 1 NC_011750.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 2957352 ygaF 7153924 ygaF Escherichia coli IAI39 hydroxyglutarate oxidase YP_002408780.1 2956084 D 585057 CDS YP_002408781.1 218701152 7153920 2957375..2958823 1 NC_011750.1 catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; succinate-semialdehyde dehydrogenase I 2958823 gabD 7153920 gabD Escherichia coli IAI39 succinate-semialdehyde dehydrogenase I YP_002408781.1 2957375 D 585057 CDS YP_002408782.1 218701153 7151460 2958837..2960117 1 NC_011750.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 2960117 gabT 7151460 gabT Escherichia coli IAI39 4-aminobutyrate aminotransferase YP_002408782.1 2958837 D 585057 CDS YP_002408783.1 218701154 7151462 complement(2960178..2960900) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 2960900 7151462 ECIAI39_2849 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002408783.1 2960178 R 585057 CDS YP_002408784.1 218701155 7150081 complement(2961005..2961535) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 2961535 7150081 ECIAI39_2850 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002408784.1 2961005 R 585057 CDS YP_002408785.1 218701156 7150082 2961789..2963189 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94127927, 9685361, 8297211; Product type t : transporter; gamma-aminobutyrate transporter 2963189 gabP 7150082 gabP Escherichia coli IAI39 gamma-aminobutyrate transporter YP_002408785.1 2961789 D 585057 CDS YP_002408786.1 218701157 7151461 2963210..2963872 1 NC_011750.1 regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 2963872 csiR 7151461 csiR Escherichia coli IAI39 DNA-binding transcriptional regulator CsiR YP_002408786.1 2963210 D 585057 CDS YP_002408787.1 218701158 7151011 complement(2963873..2964322) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; LysM domain/BON superfamily protein 2964322 ygaU 7151011 ygaU Escherichia coli IAI39 LysM domain/BON superfamily protein YP_002408787.1 2963873 R 585057 CDS YP_002408788.1 218701159 7153925 complement(2964406..2964564) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2964564 yqaE 7153925 yqaE Escherichia coli IAI39 hypothetical protein YP_002408788.1 2964406 R 585057 CDS YP_002408789.1 218701160 7154498 2964747..2965046 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2965046 ygaV 7154498 ygaV Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002408789.1 2964747 D 585057 CDS YP_002408790.1 218701161 7153926 2965056..2965580 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : putative enzyme; hypothetical protein 2965580 ygaP 7153926 ygaP Escherichia coli IAI39 hypothetical protein YP_002408790.1 2965056 D 585057 CDS YP_002408791.1 218701162 7153923 complement(2965627..2966031) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20485613, 93126121, 9643551, 98132400, 99415935, 1480493, 7961433; Product type r : regulator; DNA binding protein, nucleoid-associated 2966031 stpA 7153923 stpA Escherichia coli IAI39 DNA binding protein, nucleoid-associated YP_002408791.1 2965627 R 585057 CDS YP_002408792.1 218701163 7152917 2966698..2967147 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2967147 ygaW 7152917 ygaW Escherichia coli IAI39 hypothetical protein YP_002408792.1 2966698 D 585057 CDS YP_002408793.1 218701164 7153927 complement(2967184..2967528) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7961433; hypothetical protein 2967528 ygaC 7153927 ygaC Escherichia coli IAI39 hypothetical protein YP_002408793.1 2967184 R 585057 CDS YP_002408794.1 218701165 7153918 2967668..2968009 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2968009 ygaM 7153918 ygaM Escherichia coli IAI39 hypothetical protein YP_002408794.1 2967668 D 585057 CDS YP_002408795.1 218701166 7153922 complement(2968066..2969400) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; bifunctional aminotransaminase/GntR family transcriptional regulator 2969400 7153922 ECIAI39_2861 Escherichia coli IAI39 bifunctional aminotransaminase/GntR family transcriptional regulator YP_002408795.1 2968066 R 585057 CDS YP_002408796.1 218701167 7150083 2969488..2969919 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2969919 7150083 ECIAI39_2862 Escherichia coli IAI39 hypothetical protein YP_002408796.1 2969488 D 585057 CDS YP_002408797.1 218701168 7150084 2970128..2970373 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9218434, 11441020, 8820648; Product type pc : putative carrier; glutaredoxin-like protein 2970373 nrdH 7150084 nrdH Escherichia coli IAI39 glutaredoxin-like protein YP_002408797.1 2970128 D 585057 CDS YP_002408798.1 218701169 7152250 2970370..2970780 1 NC_011750.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 2970780 nrdI 7152250 nrdI Escherichia coli IAI39 ribonucleotide reductase stimulatory protein YP_002408798.1 2970370 D 585057 CDS YP_002408799.1 218701170 7152251 2970753..2972897 1 NC_011750.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2972897 nrdE 7152251 nrdE Escherichia coli IAI39 ribonucleotide-diphosphate reductase subunit alpha YP_002408799.1 2970753 D 585057 CDS YP_002408800.1 218701171 7152247 2972907..2973866 1 NC_011750.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 2973866 nrdF 7152247 nrdF Escherichia coli IAI39 ribonucleotide-diphosphate reductase subunit beta YP_002408800.1 2972907 D 585057 CDS YP_002408801.1 218701172 7152248 2974222..2975424 1 NC_011750.1 with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding subunit 2975424 proV 7152248 proV Escherichia coli IAI39 glycine betaine transporter ATP-binding subunit YP_002408801.1 2974222 D 585057 CDS YP_002408802.1 218701173 7152489 2975417..2976481 1 NC_011750.1 with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 2976481 proW 7152489 proW Escherichia coli IAI39 glycine betaine transporter membrane protein YP_002408802.1 2975417 D 585057 CDS YP_002408803.1 218701174 7152490 2976538..2977530 1 NC_011750.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 2977530 proX 7152490 proX Escherichia coli IAI39 glycine betaine transporter periplasmic subunit YP_002408803.1 2976538 D 585057 CDS YP_002408804.1 218701175 7152491 2977722..2978906 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16000740; Product type pt : putative transporter; putative transport protein (ousB-like) 2978906 7152491 ECIAI39_2870 Escherichia coli IAI39 putative transport protein (ousB-like) YP_002408804.1 2977722 D 585057 CDS YP_002408805.1 218701176 7150085 2979030..2979767 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 2979767 ygaZ 7150085 ygaZ Escherichia coli IAI39 putative transporter YP_002408805.1 2979030 D 585057 CDS YP_002408806.1 218701177 7153928 2979757..2980092 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2980092 ygaH 7153928 ygaH Escherichia coli IAI39 hypothetical protein YP_002408806.1 2979757 D 585057 CDS YP_002408807.1 218701178 7153921 2980183..2980713 1 NC_011750.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 2980713 mprA 7153921 mprA Escherichia coli IAI39 transcriptional repressor MprA YP_002408807.1 2980183 D 585057 CDS YP_002408808.1 218701179 7152116 complement(2980795..2982141) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase, IS4 2982141 7152116 ECIAI39_2874 Escherichia coli IAI39 transposase, IS4 YP_002408808.1 2980795 R 585057 CDS YP_002408809.1 218701180 7150086 2982278..2983450 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 93285984, 94262163, 1409590, 8203018; Product type t : transporter; multidrug efflux system 2983450 emrA 7150086 emrA Escherichia coli IAI39 multidrug efflux system YP_002408809.1 2982278 D 585057 CDS YP_002408810.1 218701181 7151214 2983467..2985005 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 93285984, 94262163, 1409590; Product type t : transporter; multidrug efflux system protein 2985005 emrB 7151214 emrB Escherichia coli IAI39 multidrug efflux system protein YP_002408810.1 2983467 D 585057 CDS YP_002408811.1 218701182 7151215 complement(2985069..2985584) 1 NC_011750.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 2985584 luxS 7151215 luxS Escherichia coli IAI39 S-ribosylhomocysteinase YP_002408811.1 2985069 R 585057 CDS YP_002408812.1 218701183 7152080 complement(2985734..2987290) 1 NC_011750.1 involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase 2987290 gshA 7152080 gshA Escherichia coli IAI39 glutamate--cysteine ligase YP_002408812.1 2985734 R 585057 CDS YP_002408813.1 218701184 7151591 complement(2987363..2987791) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2987791 yqaA 7151591 yqaA Escherichia coli IAI39 hypothetical protein YP_002408813.1 2987363 R 585057 CDS YP_002408814.1 218701185 7154496 complement(2987788..2988354) 1 NC_011750.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase 2988354 yqaB 7154496 yqaB Escherichia coli IAI39 fructose-1-phosphatase YP_002408814.1 2987788 R 585057 CDS YP_002408815.1 218701186 7150607 complement(2989411..2989596) 1 NC_011750.1 affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator 2989596 csrA 7150607 csrA Escherichia coli IAI39 carbon storage regulator YP_002408815.1 2989411 R 585057 CDS YP_002408816.1 218701187 7151021 complement(2989831..2992461) 1 NC_011750.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 2992461 alaS 7151021 alaS Escherichia coli IAI39 alanyl-tRNA synthetase YP_002408816.1 2989831 R 585057 CDS YP_002408817.1 218701188 7150710 complement(2992590..2993090) 1 NC_011750.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 2993090 recX 7150710 recX Escherichia coli IAI39 recombination regulator RecX YP_002408817.1 2992590 R 585057 CDS YP_002408818.1 218701189 7152598 complement(2993159..2994220) 1 NC_011750.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 2994220 recA 7152598 recA Escherichia coli IAI39 recombinase A YP_002408818.1 2993159 R 585057 CDS YP_002408819.1 218701190 7152587 complement(2994300..2994797) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A 2994797 ygaD 7152587 ygaD Escherichia coli IAI39 competence damage-inducible protein A YP_002408819.1 2994300 R 585057 CDS YP_002408820.1 218701191 7153919 complement(2994942..2996027) 1 NC_011750.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B 2996027 mltB 7153919 mltB Escherichia coli IAI39 murein hydrolase B YP_002408820.1 2994942 R 585057 CDS YP_002408821.1 218701192 7152090 2996283..2996846 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87194727, 1334233, 3553176; Product type t : transporter; PTS system glucitol/sorbitol-specific transporter subunit IIC 2996846 srlA 7152090 srlA Escherichia coli IAI39 PTS system glucitol/sorbitol-specific transporter subunit IIC YP_002408821.1 2996283 D 585057 CDS YP_002408822.1 218701193 7152896 2996843..2997802 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1100602, 3553176; Product type t : transporter; PTS system glucitol/sorbitol-specific transporter subunit IIB 2997802 srlE 7152896 srlE Escherichia coli IAI39 PTS system glucitol/sorbitol-specific transporter subunit IIB YP_002408822.1 2996843 D 585057 CDS YP_002408823.1 218701194 7152899 2997813..2998184 1 NC_011750.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucitol/sorbitol-specific transporter subunit IIA 2998184 srlB 7152899 srlB Escherichia coli IAI39 PTS system glucitol/sorbitol-specific transporter subunit IIA YP_002408823.1 2997813 D 585057 CDS YP_002408824.1 218701195 7152897 2998188..2998967 1 NC_011750.1 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 2998967 srlD 7152897 srlD Escherichia coli IAI39 sorbitol-6-phosphate dehydrogenase YP_002408824.1 2998188 D 585057 CDS YP_002408825.1 218701196 7152898 2999073..2999432 1 NC_011750.1 regulator for glucitol utilization; DNA-binding transcriptional activator GutM 2999432 gutM 7152898 gutM Escherichia coli IAI39 DNA-binding transcriptional activator GutM YP_002408825.1 2999073 D 585057 CDS YP_002408826.1 218701197 7151603 2999499..3000272 1 NC_011750.1 regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 3000272 srlR 7151603 srlR Escherichia coli IAI39 DNA-binding transcriptional repressor SrlR YP_002408826.1 2999499 D 585057 CDS YP_002408827.1 218701198 7152900 3000265..3001230 1 NC_011750.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 3001230 gutQ 7152900 gutQ Escherichia coli IAI39 D-arabinose 5-phosphate isomerase YP_002408827.1 3000265 D 585057 CDS YP_002408828.1 218701199 7151604 complement(3001227..3002741) 1 NC_011750.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcription regulator 3002741 norR 7151604 norR Escherichia coli IAI39 anaerobic nitric oxide reductase transcription regulator YP_002408828.1 3001227 R 585057 CDS YP_002408829.1 218701200 7152240 3002928..3004367 1 NC_011750.1 detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 3004367 norV 7152240 norV Escherichia coli IAI39 anaerobic nitric oxide reductase flavorubredoxin YP_002408829.1 3002928 D 585057 CDS YP_002408830.1 218701201 7152241 3004364..3005497 1 NC_011750.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 3005497 norW 7152241 norW Escherichia coli IAI39 nitric oxide reductase YP_002408830.1 3004364 D 585057 CDS YP_002408831.1 218701202 7152242 complement(3005576..3007888) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12377778, 92255260, 8661925; Product type e : enzyme; carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases 3007888 hypF 7152242 hypF Escherichia coli IAI39 carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases YP_002408831.1 3005576 R 585057 CDS YP_002408832.1 218701203 7151738 complement(3007969..3008496) 1 NC_011750.1 involved in electron transport from formate to hydrogen; electron transport protein HydN 3008496 hydN 7151738 hydN Escherichia coli IAI39 electron transport protein HydN YP_002408832.1 3007969 R 585057 CDS YP_002408833.1 218701204 7151720 complement(3008645..3009658) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88297127, 92334140, 1630307; Product type r : regulator; DNA-binding transcriptional repressor 3009658 ascG 7151720 ascG Escherichia coli IAI39 DNA-binding transcriptional repressor YP_002408833.1 3008645 R 585057 CDS YP_002408834.1 218701205 7150797 3009914..3011371 1 NC_011750.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC 3011371 ascF 7150797 ascF Escherichia coli IAI39 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC YP_002408834.1 3009914 D 585057 CDS YP_002408835.1 218701206 7150796 3011380..3012804 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88297127, 92334140, 1630307; Product type e : enzyme; cryptic 6-phospho-beta-glucosidase 3012804 ascB 7150796 ascB Escherichia coli IAI39 cryptic 6-phospho-beta-glucosidase YP_002408835.1 3011380 D 585057 CDS YP_002408836.1 218701207 7150795 complement(3012861..3013583) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 3013583 7150795 ECIAI39_2903 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002408836.1 3012861 R 585057 CDS YP_002408837.1 218701208 7150087 complement(3013688..3014218) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 3014218 7150087 ECIAI39_2904 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002408837.1 3013688 R 585057 CDS YP_002408838.1 218701209 7150088 complement(3014398..3014868) 1 NC_011750.1 involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease 3014868 hycI 7150088 hycI Escherichia coli IAI39 hydrogenase 3 maturation protease YP_002408838.1 3014398 R 585057 CDS YP_002408839.1 218701210 7151719 complement(3014861..3015271) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 92326636, 1625581, 2187144, 7851435; Product type f : factor; hydrogenase 3 maturation protein 3015271 hycH 7151719 hycH Escherichia coli IAI39 hydrogenase 3 maturation protein YP_002408839.1 3014861 R 585057 CDS YP_002408840.1 218701211 7151718 complement(3015268..3016035) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636, 2187144; Product type e : enzyme; hydrogenase 3 and formate hydrogenase complex subunit HycG 3016035 hycG 7151718 hycG Escherichia coli IAI39 hydrogenase 3 and formate hydrogenase complex subunit HycG YP_002408840.1 3015268 R 585057 CDS YP_002408841.1 218701212 7151717 complement(3016035..3016577) 1 NC_011750.1 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; formate hydrogenlyase complex iron-sulfur subunit 3016577 hycF 7151717 hycF Escherichia coli IAI39 formate hydrogenlyase complex iron-sulfur subunit YP_002408841.1 3016035 R 585057 CDS YP_002408842.1 218701213 7151716 complement(3016587..3018296) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 92326636, 94170785, 2187144, 8125094; Product type e : enzyme; hydrogenase 3, large subunit 3018296 hycE 7151716 hycE Escherichia coli IAI39 hydrogenase 3, large subunit YP_002408842.1 3016587 R 585057 CDS YP_002408843.1 218701214 7151715 complement(3018314..3019237) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636; Product type m : membrane component; hydrogenase 3, membrane subunit 3019237 hycD 7151715 hycD Escherichia coli IAI39 hydrogenase 3, membrane subunit YP_002408843.1 3018314 R 585057 CDS YP_002408844.1 218701215 7151714 complement(3019240..3021066) 1 NC_011750.1 catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 3021066 hycC 7151714 hycC Escherichia coli IAI39 formate hydrogenlyase subunit 3 YP_002408844.1 3019240 R 585057 CDS YP_002408845.1 218701216 7151713 complement(3021063..3021674) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636, 2187144; Product type c : carrier; hydrogenase 3, Fe-S subunit 3021674 hycB 7151713 hycB Escherichia coli IAI39 hydrogenase 3, Fe-S subunit YP_002408845.1 3021063 R 585057 CDS YP_002408846.1 218701217 7151712 complement(3021799..3022260) 1 NC_011750.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA 3022260 hycA 7151712 hycA Escherichia coli IAI39 formate hydrogenlyase regulatory protein HycA YP_002408846.1 3021799 R 585057 CDS YP_002408847.1 218701218 7151711 3022472..3022822 1 NC_011750.1 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 3022822 hypA 7151711 hypA Escherichia coli IAI39 hydrogenase nickel incorporation protein YP_002408847.1 3022472 D 585057 CDS YP_002408848.1 218701219 7151733 3022826..3023698 1 NC_011750.1 GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 3023698 hypB 7151733 hypB Escherichia coli IAI39 hydrogenase nickel incorporation protein HypB YP_002408848.1 3022826 D 585057 CDS YP_002408849.1 218701220 7151734 3023689..3023961 1 NC_011750.1 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 3023961 hypC 7151734 hypC Escherichia coli IAI39 hydrogenase assembly chaperone YP_002408849.1 3023689 D 585057 CDS YP_002408850.1 218701221 7151735 3023961..3025082 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91194542, 92255260, 1849603; Product type f : factor; hydrogenase maturation protein 3025082 hypD 7151735 hypD Escherichia coli IAI39 hydrogenase maturation protein YP_002408850.1 3023961 D 585057 CDS YP_002408851.1 218701222 7151736 3025121..3026089 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91194542, 9485446, 1849603; Product type e : enzyme; carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein 3026089 hypE 7151736 hypE Escherichia coli IAI39 carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein YP_002408851.1 3025121 D 585057 CDS YP_002408852.1 218701223 7151737 3026163..3028241 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20307603, 21557168, 90368529, 92140045, 94018617, 2118503, 2280686; Product type r : regulator; DNA-binding transcriptional activator 3028241 fhlA 7151737 fhlA Escherichia coli IAI39 DNA-binding transcriptional activator YP_002408852.1 3026163 D 585057 CDS YP_002408853.1 218701224 7151313 3028247..3028714 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative molybdenum-pterin-binding-protein 3028714 7151313 ECIAI39_2921 Escherichia coli IAI39 putative molybdenum-pterin-binding-protein YP_002408853.1 3028247 D 585057 CDS YP_002408854.1 218701225 7150089 complement(3028753..3029097) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3029097 ygbA 7150089 ygbA Escherichia coli IAI39 hypothetical protein YP_002408854.1 3028753 R 585057 CDS YP_002408855.1 218701226 7153929 3029384..3031945 1 NC_011750.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 3031945 mutS 7153929 mutS Escherichia coli IAI39 DNA mismatch repair protein MutS YP_002408855.1 3029384 D 585057 CDS YP_002408856.1 218701227 7152158 3032051..3032707 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9130712; Product type e : enzyme; serine/threonine-specific protein phosphatase 2 3032707 pphB 7152158 pphB Escherichia coli IAI39 serine/threonine-specific protein phosphatase 2 YP_002408856.1 3032051 D 585057 CDS YP_002408857.1 218701228 7152459 complement(3032749..3032985) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme; putative non-oxidative hydroxyarylic acid decarboxylase 3032985 7152459 ECIAI39_2925 Escherichia coli IAI39 putative non-oxidative hydroxyarylic acid decarboxylase YP_002408857.1 3032749 R 585057 CDS YP_002408858.1 218701229 7150090 complement(3032996..3034423) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme; putative non-oxidative hydroxyarylic acid decarboxylase 3034423 7150090 ECIAI39_2926 Escherichia coli IAI39 putative non-oxidative hydroxyarylic acid decarboxylase YP_002408858.1 3032996 R 585057 CDS YP_002408859.1 218701230 7150091 complement(3034423..3035016) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme; putative non-oxidative hydroxyarylic acid decarboxylase 3035016 7150091 ECIAI39_2927 Escherichia coli IAI39 putative non-oxidative hydroxyarylic acid decarboxylase YP_002408859.1 3034423 R 585057 CDS YP_002408860.1 218701231 7150092 3035163..3035570 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15731069; Product type r : regulator; transcriptional regulator hosA 3035570 7150092 ECIAI39_2928 Escherichia coli IAI39 transcriptional regulator hosA YP_002408860.1 3035163 D 585057 CDS YP_002408861.1 218701232 7150093 complement(3035691..3036683) 1 NC_011750.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses; RNA polymerase sigma factor RpoS 3036683 rpoS 7150093 rpoS Escherichia coli IAI39 RNA polymerase sigma factor RpoS YP_002408861.1 3035691 R 585057 CDS YP_002408862.1 218701233 7152710 complement(3036746..3037885) 1 NC_011750.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD 3037885 nlpD 7152710 nlpD Escherichia coli IAI39 lipoprotein NlpD YP_002408862.1 3036746 R 585057 CDS YP_002408863.1 218701234 7152236 complement(3038025..3038651) 1 NC_011750.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase 3038651 pcm 7152236 pcm Escherichia coli IAI39 protein-L-isoaspartate O-methyltransferase YP_002408863.1 3038025 R 585057 CDS YP_002408864.1 218701235 7152352 complement(3038645..3039406) 1 NC_011750.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 3039406 surE 7152352 surE Escherichia coli IAI39 stationary phase survival protein SurE YP_002408864.1 3038645 R 585057 CDS YP_002408865.1 218701236 7152933 complement(3039387..3040436) 1 NC_011750.1 catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D 3040436 truD 7152933 truD Escherichia coli IAI39 tRNA pseudouridine synthase D YP_002408865.1 3039387 R 585057 CDS YP_002408866.1 218701237 7153042 complement(3040433..3040912) 1 NC_011750.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 3040912 ispF 7153042 ispF Escherichia coli IAI39 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_002408866.1 3040433 R 585057 CDS YP_002408867.1 218701238 7151855 complement(3040912..3041622) 1 NC_011750.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 3041622 ispD 7151855 ispD Escherichia coli IAI39 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_002408867.1 3040912 R 585057 CDS YP_002408868.1 218701239 7151853 complement(3041641..3041952) 1 NC_011750.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB 3041952 ftsB 7151853 ftsB Escherichia coli IAI39 cell division protein FtsB YP_002408868.1 3041641 R 585057 CDS YP_002408869.1 218701240 7151434 complement(3042146..3042469) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3042469 ygbE 7151434 ygbE Escherichia coli IAI39 hypothetical protein YP_002408869.1 3042146 R 585057 CDS YP_002408870.1 218701241 7153930 complement(3042519..3043124) 1 NC_011750.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase 3043124 cysC 7153930 cysC Escherichia coli IAI39 adenylylsulfate kinase YP_002408870.1 3042519 R 585057 CDS YP_002408871.1 218701242 7151057 complement(3043124..3044551) 1 NC_011750.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 3044551 cysN 7151057 cysN Escherichia coli IAI39 sulfate adenylyltransferase subunit 1 YP_002408871.1 3043124 R 585057 CDS YP_002408872.1 218701243 7151066 complement(3044553..3045461) 1 NC_011750.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 3045461 cysD 7151066 cysD Escherichia coli IAI39 sulfate adenylyltransferase subunit 2 YP_002408872.1 3044553 R 585057 CDS YP_002408873.1 218701244 7151058 3045713..3046750 1 NC_011750.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase isozyme conversion aminopeptidase 3046750 iap 7151058 iap Escherichia coli IAI39 alkaline phosphatase isozyme conversion aminopeptidase YP_002408873.1 3045713 D 585057 CDS YP_002408874.1 218701245 7151743 complement(3046877..3047029) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type pm : putative membrane component; small toxic peptide 3047029 7151743 ECIAI39_2943 Escherichia coli IAI39 small toxic peptide YP_002408874.1 3046877 R 585057 CDS YP_002408875.1 218701246 7150094 complement(3047294..3048028) 1 NC_011750.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 3048028 cysH 7150094 cysH Escherichia coli IAI39 phosphoadenosine phosphosulfate reductase YP_002408875.1 3047294 R 585057 CDS YP_002408876.1 218701247 7151061 complement(3048102..3049814) 1 NC_011750.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta 3049814 cysI 7151061 cysI Escherichia coli IAI39 sulfite reductase subunit beta YP_002408876.1 3048102 R 585057 CDS YP_002408877.1 218701248 7151062 complement(3049814..3051613) 1 NC_011750.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha 3051613 cysJ 7151062 cysJ Escherichia coli IAI39 sulfite reductase subunit alpha YP_002408877.1 3049814 R 585057 CDS YP_002408878.1 218701249 7151063 3051929..3052294 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123838; Product type e : enzyme; 6-pyruvoyl tetrahydrobiopterin synthase 3052294 ygcM 7151063 ygcM Escherichia coli IAI39 6-pyruvoyl tetrahydrobiopterin synthase YP_002408878.1 3051929 D 585057 CDS YP_002408879.1 218701250 7153934 3052372..3053643 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 3053643 ygcN 7153934 ygcN Escherichia coli IAI39 putative oxidoreductase YP_002408879.1 3052372 D 585057 CDS YP_002408880.1 218701251 7153935 3053634..3053894 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S cluster-containing protein 3053894 ygcO 7153935 ygcO Escherichia coli IAI39 putative 4Fe-4S cluster-containing protein YP_002408880.1 3053634 D 585057 CDS YP_002408881.1 218701252 7153936 3053911..3054486 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative anti-terminator regulatory protein 3054486 ygcP 7153936 ygcP Escherichia coli IAI39 putative anti-terminator regulatory protein YP_002408881.1 3053911 D 585057 CDS YP_002408882.1 218701253 7153937 complement(3054633..3055493) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative flavoprotein 3055493 ygcQ 7153937 ygcQ Escherichia coli IAI39 putative flavoprotein YP_002408882.1 3054633 R 585057 CDS YP_002408883.1 218701254 7153938 complement(3055490..3056269) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative flavoprotein 3056269 ygcR 7153938 ygcR Escherichia coli IAI39 putative flavoprotein YP_002408883.1 3055490 R 585057 CDS YP_002408884.1 218701255 7153939 complement(3056247..3057584) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3057584 ygcS 7153939 ygcS Escherichia coli IAI39 putative transporter YP_002408884.1 3056247 R 585057 CDS YP_002408885.1 218701256 7153940 complement(3057678..3059132) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative FAD containing dehydrogenase 3059132 ygcU 7153940 ygcU Escherichia coli IAI39 putative FAD containing dehydrogenase YP_002408885.1 3057678 R 585057 CDS YP_002408886.1 218701257 7153941 complement(3059202..3059987) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative deoxygluconate dehydrogenase 3059987 ygcW 7153941 ygcW Escherichia coli IAI39 putative deoxygluconate dehydrogenase YP_002408886.1 3059202 R 585057 CDS YP_002408887.1 218701258 7154501 complement(3060701..3061147) 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 3061147 7154501 ECIAI39_2957 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002408887.1 3060701 R 585057 CDS YP_002408888.1 218701259 7150095 complement(3061264..3062787) 1 NC_011750.1 Group II intron-encoded reverse transcriptase/maturase 3062787 7150095 ECIAI39_2958 Escherichia coli IAI39 Group II intron-encoded reverse transcriptase/maturase YP_002408888.1 3061264 R 585057 CDS YP_002408889.1 218701260 7150096 complement(3063379..3063861) 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 3063861 7150096 ECIAI39_2959 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002408889.1 3063379 R 585057 CDS YP_002408890.1 218701261 7150097 complement(3063858..3064184) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 3064184 7150097 ECIAI39_2960 Escherichia coli IAI39 transposase ORF A, IS629 YP_002408890.1 3063858 R 585057 CDS YP_002408891.1 218701262 7154502 3065193..3066671 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative kinase 3066671 ygcE 7154502 ygcE Escherichia coli IAI39 putative kinase YP_002408891.1 3065193 D 585057 CDS YP_002408892.1 218701263 7153931 3066836..3067756 1 NC_011750.1 phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least; aminoimidazole riboside kinase 3067756 7153931 ECIAI39_2963 Escherichia coli IAI39 aminoimidazole riboside kinase YP_002408892.1 3066836 D 585057 CDS YP_002408893.1 218701264 7150099 3067924..3069441 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type m : membrane component; Sucrose porin 3069441 7150099 ECIAI39_2964 Escherichia coli IAI39 Sucrose porin YP_002408893.1 3067924 D 585057 CDS YP_002408894.1 218701265 7150100 3069502..3070872 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; PTS system sucrose-specific EIIBC component 3070872 7150100 ECIAI39_2965 Escherichia coli IAI39 PTS system sucrose-specific EIIBC component YP_002408894.1 3069502 D 585057 CDS YP_002408895.1 218701266 7150101 3070872..3072281 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; sucrose-6-phosphate hydrolase 3072281 7150101 ECIAI39_2966 Escherichia coli IAI39 sucrose-6-phosphate hydrolase YP_002408895.1 3070872 D 585057 CDS YP_002408896.1 218701267 7150102 3072307..3073314 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Sucrose operon repressor 3073314 7150102 ECIAI39_2967 Escherichia coli IAI39 Sucrose operon repressor YP_002408896.1 3072307 D 585057 CDS YP_002408897.1 218701268 7150103 complement(3073399..3074070) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3074070 ygcF 7150103 ygcF Escherichia coli IAI39 hypothetical protein YP_002408897.1 3073399 R 585057 CDS YP_002408898.1 218701269 7153932 3074032..3074100 1 NC_011750.1 hypothetical protein 3074100 7153932 ECIAI39_2969 Escherichia coli IAI39 hypothetical protein YP_002408898.1 3074032 D 585057 CDS YP_002408899.1 218701270 7150104 3074364..3075236 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3075236 ygcG 7150104 ygcG Escherichia coli IAI39 hypothetical protein YP_002408899.1 3074364 D 585057 CDS YP_002408900.1 218701271 7153933 complement(3075282..3076628) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element 3076628 insG 7153933 insG Escherichia coli IAI39 putative IS4 transposase; KpLE2 phage-like element YP_002408900.1 3075282 R 585057 CDS YP_002408901.1 218701272 7154207 3077218..3078120 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3078120 7154207 ECIAI39_2973 Escherichia coli IAI39 hypothetical protein YP_002408901.1 3077218 D 585057 CDS YP_002408902.1 218701273 7150105 complement(3078175..3080337) 1 NC_011750.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 3080337 uvrD 7150105 uvrD Escherichia coli IAI39 DNA-dependent helicase II YP_002408902.1 3078175 R 585057 CDS YP_002408903.1 218701274 7153116 complement(3080421..3081137) 1 NC_011750.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 3081137 yigB 7153116 yigB Escherichia coli IAI39 flavin mononucleotide phosphatase YP_002408903.1 3080421 R 585057 CDS YP_002408904.1 218701275 7154206 complement(3081137..3082033) 1 NC_011750.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 3082033 xerC 7154206 xerC Escherichia coli IAI39 site-specific tyrosine recombinase XerC YP_002408904.1 3081137 R 585057 CDS YP_002408905.1 218701276 7153179 complement(3082030..3082737) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3082737 yigA 7153179 yigA Escherichia coli IAI39 hypothetical protein YP_002408905.1 3082030 R 585057 CDS YP_002408906.1 218701277 7154205 complement(3082734..3083558) 1 NC_011750.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 3083558 dapF 7154205 dapF Escherichia coli IAI39 diaminopimelate epimerase YP_002408906.1 3082734 R 585057 CDS YP_002408907.1 218701278 7151088 complement(3083595..3083798) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein 3083798 yifL 7151088 yifL Escherichia coli IAI39 putative lipoprotein YP_002408907.1 3083595 R 585057 CDS YP_002408908.1 218701279 7154204 3084140..3084694 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3084694 7154204 ECIAI39_2980 Escherichia coli IAI39 hypothetical protein YP_002408908.1 3084140 D 585057 CDS YP_002408909.1 218701280 7150106 3084735..3084950 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3084950 7150106 ECIAI39_2981 Escherichia coli IAI39 hypothetical protein YP_002408909.1 3084735 D 585057 CDS YP_002408910.1 218701281 7150107 3085037..3087094 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3087094 7150107 ECIAI39_2982 Escherichia coli IAI39 hypothetical protein YP_002408910.1 3085037 D 585057 CDS YP_002408911.1 218701282 7150108 3087142..3087462 1 NC_011750.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 3087462 cyaY 7150108 cyaY Escherichia coli IAI39 frataxin-like protein YP_002408911.1 3087142 D 585057 CDS YP_002408912.1 218701283 7151039 complement(3087502..3090048) 1 NC_011750.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 3090048 cyaA 7151039 cyaA Escherichia coli IAI39 adenylate cyclase YP_002408912.1 3087502 R 585057 CDS YP_002408913.1 218701284 7151038 3090435..3091376 1 NC_011750.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 3091376 hemC 7151038 hemC Escherichia coli IAI39 porphobilinogen deaminase YP_002408913.1 3090435 D 585057 CDS YP_002408914.1 218701285 7151626 3091373..3092113 1 NC_011750.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 3092113 hemD 7151626 hemD Escherichia coli IAI39 uroporphyrinogen-III synthase YP_002408914.1 3091373 D 585057 CDS YP_002408915.1 218701286 7151627 3092135..3093316 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 89098348, 92358234, 3054815, 3062586, 9298646; Product type pe : putative enzyme; putative uroporphyrinogen III C-methyltransferase 3093316 hemX 7151627 hemX Escherichia coli IAI39 putative uroporphyrinogen III C-methyltransferase YP_002408915.1 3092135 D 585057 CDS YP_002408916.1 218701287 7151634 3093319..3094515 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 89041586; Product type pe : putative enzyme; putative protoheme IX biogenesis protein 3094515 hemY 7151634 hemY Escherichia coli IAI39 putative protoheme IX biogenesis protein YP_002408916.1 3093319 D 585057 CDS YP_002408917.1 218701288 7152793 3095201..3096856 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16766528, 92358234, 15477040; Product type e : enzyme; arylsulfatase-like enzyme 3096856 aslA 7152793 aslA Escherichia coli IAI39 arylsulfatase-like enzyme YP_002408917.1 3095201 D 585057 CDS YP_002408918.1 218701289 7150799 complement(3097014..3098249) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11222759, 2180918, 12419807, 14749327; Product type pr : putative regulator; regulator of arylsulfatase activity 3098249 aslB 7150799 aslB Escherichia coli IAI39 regulator of arylsulfatase activity YP_002408918.1 3097014 R 585057 CDS YP_002408919.1 218701290 7150602 complement(3098935..3100320) 1 NC_011750.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; putative transport protein YifK 3100320 yifK 7150602 yifK Escherichia coli IAI39 putative transport protein YifK YP_002408919.1 3098935 R 585057 CDS YP_002408920.1 218701291 7154203 complement(3100511..3101251) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88086874, 90337949, 92112804; Product type e : enzyme; putative UDP-N-acetyl-D-mannosaminuronic acid transferase 3101251 rffM 7154203 rffM Escherichia coli IAI39 putative UDP-N-acetyl-D-mannosaminuronic acid transferase YP_002408920.1 3100511 R 585057 CDS YP_002408921.1 218701292 7152610 complement(3101254..3102606) 1 NC_011750.1 enterobacterial common antigen polymerase; putative common antigen polymerase 3102606 wzyE 7152610 wzyE Escherichia coli IAI39 putative common antigen polymerase YP_002408921.1 3101254 R 585057 CDS YP_002408922.1 218701293 7153169 complement(3102603..3103682) 1 NC_011750.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 3103682 rffT 7153169 rffT Escherichia coli IAI39 4-alpha-L-fucosyltransferase YP_002408922.1 3102603 R 585057 CDS YP_002408923.1 218701294 7152611 complement(3103679..3104929) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12621029, 20044778; Product type t : transporter; O-antigen translocase 3104929 wzxE 7152611 wzxE Escherichia coli IAI39 O-antigen translocase YP_002408923.1 3103679 R 585057 CDS YP_002408924.1 218701295 7153167 complement(3104931..3106061) 1 NC_011750.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 3106061 rffA 7153167 rffA Escherichia coli IAI39 TDP-4-oxo-6-deoxy-D-glucose transaminase YP_002408924.1 3104931 R 585057 CDS YP_002408925.1 218701296 7152604 complement(3106066..3106740) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90212314, 90337949, 92112804, 8366065; Product type e : enzyme; TDP-fucosamine acetyltransferase 3106740 rffC 7152604 rffC Escherichia coli IAI39 TDP-fucosamine acetyltransferase YP_002408925.1 3106066 R 585057 CDS YP_002408926.1 218701297 7152605 complement(3106718..3107599) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94292435, 96032389; Product type e : enzyme; glucose-1-phosphate thymidylyltransferase 3107599 rffH 7152605 rffH Escherichia coli IAI39 glucose-1-phosphate thymidylyltransferase YP_002408926.1 3106718 R 585057 CDS YP_002408927.1 218701298 7152609 complement(3107618..3108685) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88086930, 90212314, 90337949, 92112804, 92174908, 94018634, 94042873, 7559340; Product type e : enzyme; dTDP-glucose 4,6-dehydratase 3108685 rffG 7152609 rffG Escherichia coli IAI39 dTDP-glucose 4,6-dehydratase YP_002408927.1 3107618 R 585057 CDS YP_002408928.1 218701299 7152608 complement(3108685..3109947) 1 NC_011750.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 3109947 wecC 7152608 wecC Escherichia coli IAI39 UDP-N-acetyl-D-mannosamine dehydrogenase YP_002408928.1 3108685 R 585057 CDS YP_002408929.1 218701300 7152606 complement(3109944..3111074) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90212314, 90337949, 92112804, 94042873, 11106477, 7559340, 8170390, 8226648; Product type e : enzyme; UDP-N-acetyl glucosamine-2-epimerase 3111074 rffE 7152606 rffE Escherichia coli IAI39 UDP-N-acetyl glucosamine-2-epimerase YP_002408929.1 3109944 R 585057 CDS YP_002408930.1 218701301 7152607 complement(3111130..3112176) 1 NC_011750.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 3112176 wzzE 7152607 wzzE Escherichia coli IAI39 lipopolysaccharide biosynthesis protein WzzE YP_002408930.1 3111130 R 585057 CDS YP_002408931.1 218701302 7153170 complement(3112188..3113291) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92114763, 94245613, 94292435, 10629198, 11024259, 11700352, 11832520, 1722555, 1730666; Product type e : enzyme; UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase 3113291 rfe 7153170 rfe Escherichia coli IAI39 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase YP_002408931.1 3112188 R 585057 CDS YP_002408932.1 218701303 7152603 complement(3113303..3113521) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3113521 7152603 ECIAI39_3004 Escherichia coli IAI39 hypothetical protein YP_002408932.1 3113303 R 585057 CDS YP_002408933.1 218701304 7150109 complement(3113531..3114790) 1 NC_011750.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 3114790 rho 7150109 rho Escherichia coli IAI39 transcription termination factor Rho YP_002408933.1 3113531 R 585057 CDS YP_002408934.1 218701305 7152620 complement(3114875..3114976) 1 NC_011750.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; putative rho operon leader peptide 3114976 rhoL 7152620 rhoL Escherichia coli IAI39 putative rho operon leader peptide YP_002408934.1 3114875 R 585057 CDS YP_002408935.1 218701306 7152621 complement(3115117..3115446) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202710, 91154193, 92250497, 99175138, 10489448, 1094461, 10947986, 1561103, 2181145, 2193685, 3891733, 4616096, 4883076, 6098320, 6099324, 7812718, 8098620, 8253691; Product type c : carrier; thioredoxin 3115446 trxA 7152621 trxA Escherichia coli IAI39 thioredoxin YP_002408935.1 3115117 R 585057 CDS YP_002408936.1 218701307 7153043 3115577..3116842 1 NC_011750.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB 3116842 rhlB 7153043 rhlB Escherichia coli IAI39 ATP-dependent RNA helicase RhlB YP_002408936.1 3115577 D 585057 CDS YP_002408937.1 218701308 7152618 3116978..3118462 1 NC_011750.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase 3118462 gpp 7152618 gpp Escherichia coli IAI39 guanosine pentaphosphate phosphohydrolase YP_002408937.1 3116978 D 585057 CDS YP_002408938.1 218701309 7151580 complement(3118509..3120530) 1 NC_011750.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 3120530 rep 7151580 rep Escherichia coli IAI39 ATP-dependent DNA helicase Rep YP_002408938.1 3118509 R 585057 CDS YP_002408939.1 218701310 7152600 3120706..3121197 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3121197 7152600 ECIAI39_3010 Escherichia coli IAI39 hypothetical protein YP_002408939.1 3120706 D 585057 CDS YP_002408940.1 218701311 7150110 3121350..3121631 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94215709, 7878732, 7925971, 8163020; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase C 3121631 ppiC 7150110 ppiC Escherichia coli IAI39 peptidyl-prolyl cis-trans isomerase C YP_002408940.1 3121350 D 585057 CDS YP_002408941.1 218701312 7152462 complement(3121677..3123152) 1 NC_011750.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 3123152 ilvC 7152462 ilvC Escherichia coli IAI39 ketol-acid reductoisomerase YP_002408941.1 3121677 R 585057 CDS YP_002408942.1 218701313 7151765 3123218..3124192 1 NC_011750.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 3124192 ilvY 7151765 ilvY Escherichia coli IAI39 DNA-binding transcriptional regulator IlvY YP_002408942.1 3123218 D 585057 CDS YP_002408943.1 218701314 7151774 complement(3124189..3125733) 1 NC_011750.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 3125733 ilvA 7151774 ilvA Escherichia coli IAI39 threonine dehydratase YP_002408943.1 3124189 R 585057 CDS YP_002408944.1 218701315 7151763 complement(3125736..3127586) 1 NC_011750.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 3127586 ilvD 7151763 ilvD Escherichia coli IAI39 dihydroxy-acid dehydratase YP_002408944.1 3125736 R 585057 CDS YP_002408945.1 218701316 7151766 complement(3127651..3128580) 1 NC_011750.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 3128580 ilvE 7151766 ilvE Escherichia coli IAI39 branched-chain amino acid aminotransferase YP_002408945.1 3127651 R 585057 CDS YP_002408946.1 218701317 7151767 complement(3128600..3128863) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92332418, 92380929, 1569580, 3550695, 3897211; Product type e : enzyme; acetolactate synthase 2 regulatory subunit 3128863 ilvM 7151767 ilvM Escherichia coli IAI39 acetolactate synthase 2 regulatory subunit YP_002408946.1 3128600 R 585057 CDS YP_002408947.1 218701318 7151772 complement(3128860..3130506) 1 NC_011750.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 3130506 ilvG 7151772 ilvG Escherichia coli IAI39 acetolactate synthase 2 catalytic subunit YP_002408947.1 3128860 R 585057 CDS YP_002408948.1 218701319 7151768 complement(3130646..3130744) 1 NC_011750.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; ilvG operon leader peptide 3130744 ilvL 7151768 ilvL Escherichia coli IAI39 ilvG operon leader peptide YP_002408948.1 3130646 R 585057 CDS YP_002408949.1 218701320 7151771 3131067..3132617 1 NC_011750.1 among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function; putative ATP-dependent protease 3132617 yifB 7151771 yifB Escherichia coli IAI39 putative ATP-dependent protease YP_002408949.1 3131067 D 585057 CDS YP_002408950.1 218701321 7154201 complement(3132642..3132980) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3132980 yifE 7154201 yifE Escherichia coli IAI39 hypothetical protein YP_002408950.1 3132642 R 585057 CDS YP_002408951.1 218701322 7154202 3133099..3133938 1 NC_011750.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR 3133938 hdfR 7154202 hdfR Escherichia coli IAI39 transcriptional regulator HdfR YP_002408951.1 3133099 D 585057 CDS YP_002408952.1 218701323 7149776 complement(3139670..3140527) 1 NC_011750.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 3140527 murI 7149776 murI Escherichia coli IAI39 glutamate racemase YP_002408952.1 3139670 R 585057 CDS YP_002408953.1 218701324 7152152 complement(3140472..3142316) 1 NC_011750.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 3142316 btuB 7152152 btuB Escherichia coli IAI39 vitamin B12/cobalamin outer membrane transporter YP_002408953.1 3140472 R 585057 CDS YP_002408954.1 218701325 7150541 3142685..3143785 1 NC_011750.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 3143785 trmA 7150541 trmA Escherichia coli IAI39 tRNA (uracil-5-)-methyltransferase YP_002408954.1 3142685 D 585057 CDS YP_002408955.1 218701326 7153025 complement(3143825..3144184) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3144184 yijD 7153025 yijD Escherichia coli IAI39 hypothetical protein YP_002408955.1 3143825 R 585057 CDS YP_002408956.1 218701327 7154246 complement(3144184..3144888) 1 NC_011750.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 3144888 fabR 7154246 fabR Escherichia coli IAI39 DNA-binding transcriptional repressor FabR YP_002408956.1 3144184 R 585057 CDS YP_002408957.1 218701328 7151270 3145166..3146566 1 NC_011750.1 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 3146566 sthA 7151270 sthA Escherichia coli IAI39 soluble pyridine nucleotide transhydrogenase YP_002408957.1 3145166 D 585057 CDS YP_002408958.1 218701329 7152916 complement(3146549..3147466) 1 NC_011750.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 3147466 oxyR 7152916 oxyR Escherichia coli IAI39 DNA-binding transcriptional regulator OxyR YP_002408958.1 3146549 R 585057 CDS YP_002408959.1 218701330 7152316 complement(3147732..3149105) 1 NC_011750.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 3149105 argH 7152316 argH Escherichia coli IAI39 argininosuccinate lyase YP_002408959.1 3147732 R 585057 CDS YP_002408960.1 218701331 7150766 complement(3149166..3149939) 1 NC_011750.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 3149939 argB 7150766 argB Escherichia coli IAI39 acetylglutamate kinase YP_002408960.1 3149166 R 585057 CDS YP_002408961.1 218701332 7150761 complement(3149950..3150954) 1 NC_011750.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 3150954 argC 7150761 argC Escherichia coli IAI39 N-acetyl-gamma-glutamyl-phosphate reductase YP_002408961.1 3149950 R 585057 CDS YP_002408962.1 218701333 7150762 3151108..3152259 1 NC_011750.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase 3152259 argE 7150762 argE Escherichia coli IAI39 acetylornithine deacetylase YP_002408962.1 3151108 D 585057 CDS YP_002408963.1 218701334 7150764 3152561..3155212 1 NC_011750.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 3155212 ppc 7150764 ppc Escherichia coli IAI39 phosphoenolpyruvate carboxylase YP_002408963.1 3152561 D 585057 CDS YP_002408964.1 218701335 7152453 3155395..3157128 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10456927; Product type pm : putative membrane component; hypothetical protein 3157128 yijP 7152453 yijP Escherichia coli IAI39 hypothetical protein YP_002408964.1 3155395 D 585057 CDS YP_002408965.1 218701336 7154250 3157277..3158128 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3158128 yijO 7154250 yijO Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002408965.1 3157277 D 585057 CDS YP_002408966.1 218701337 7154249 complement(3158115..3158456) 1 NC_011750.1 FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; putative fructose-like phosphotransferase EIIB subunit 3 3158456 frwD 7154249 frwD Escherichia coli IAI39 putative fructose-like phosphotransferase EIIB subunit 3 YP_002408966.1 3158115 R 585057 CDS YP_002408967.1 218701338 7151429 complement(3158458..3159336) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95291446, 14673546, 7773398; Product type e : enzyme; pyruvate formate lyase II activase 3159336 pflC 7151429 pflC Escherichia coli IAI39 pyruvate formate lyase II activase YP_002408967.1 3158458 R 585057 CDS YP_002408968.1 218701339 7152374 complement(3159302..3161599) 1 NC_011750.1 involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; putative formate acetyltransferase 2 3161599 pflD 7152374 pflD Escherichia coli IAI39 putative formate acetyltransferase 2 YP_002408968.1 3159302 R 585057 CDS YP_002408969.1 218701340 7152375 complement(3161650..3161970) 1 NC_011750.1 FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; putative PTS system fructose-like transporter subunit EIIB 3161970 frwB 7152375 frwB Escherichia coli IAI39 putative PTS system fructose-like transporter subunit EIIB YP_002408969.1 3161650 R 585057 CDS YP_002408970.1 218701341 7151427 complement(3161985..3163064) 1 NC_011750.1 FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site; putative fructose-like permease EIIC subunit 2 3163064 frwC 7151427 frwC Escherichia coli IAI39 putative fructose-like permease EIIC subunit 2 YP_002408970.1 3161985 R 585057 CDS YP_002408971.1 218701342 7151428 3163373..3165874 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 95291446, 7773398; Product type t : transporter; putative PTS system Hpr component/enzyme I component/subunit IIA 3165874 ptsA 7151428 ptsA Escherichia coli IAI39 putative PTS system Hpr component/enzyme I component/subunit IIA YP_002408971.1 3163373 D 585057 CDS YP_002408972.1 218701343 7152517 3165886..3166548 1 NC_011750.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 3166548 fsaB 7152517 fsaB Escherichia coli IAI39 fructose-6-phosphate aldolase YP_002408972.1 3165886 D 585057 CDS YP_002408973.1 218701344 7151431 3166559..3167662 1 NC_011750.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 3167662 gldA 7151431 gldA Escherichia coli IAI39 glycerol dehydrogenase YP_002408973.1 3166559 D 585057 CDS YP_002408974.1 218701345 7151511 3167937..3168554 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3168554 yijF 7151511 yijF Escherichia coli IAI39 hypothetical protein YP_002408974.1 3167937 D 585057 CDS YP_002408975.1 218701346 7154248 complement(3168581..3169486) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease 3169486 yijE 7154248 yijE Escherichia coli IAI39 putative permease YP_002408975.1 3168581 R 585057 CDS YP_002408976.1 218701347 7154247 complement(3169580..3171760) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90292022, 94209230, 3045098; Product type e : enzyme; catalase/hydroperoxidase HPI(I) 3171760 katG 7154247 katG Escherichia coli IAI39 catalase/hydroperoxidase HPI(I) YP_002408976.1 3169580 R 585057 CDS YP_002408977.1 218701348 7151872 complement(3172088..3172978) 1 NC_011750.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 3172978 metF 7151872 metF Escherichia coli IAI39 5,10-methylenetetrahydrofolate reductase YP_002408977.1 3172088 R 585057 CDS YP_002408978.1 218701349 7152054 complement(3173360..3174919) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphoesterase 3174919 7152054 ECIAI39_3048 Escherichia coli IAI39 putative phosphoesterase YP_002408978.1 3173360 R 585057 CDS YP_002408979.1 218701350 7150111 3175046..3176173 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3176173 7150111 ECIAI39_3049 Escherichia coli IAI39 hypothetical protein YP_002408979.1 3175046 D 585057 CDS YP_002408980.1 218701351 7150112 complement(3175466..3175627) 1 NC_011750.1 hypothetical protein 3175627 7150112 ECIAI39_3050 Escherichia coli IAI39 hypothetical protein YP_002408980.1 3175466 R 585057 CDS YP_002408981.1 218701352 7150113 3176403..3177956 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 5'-nucleotidase 3177956 7150113 ECIAI39_3051 Escherichia coli IAI39 putative 5'-nucleotidase YP_002408981.1 3176403 D 585057 CDS YP_002408982.1 218701353 7150114 3177991..3179616 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 5'-nucleotidase/2',3'-cyclic phosphodiesterase 3179616 7150114 ECIAI39_3052 Escherichia coli IAI39 putative 5'-nucleotidase/2',3'-cyclic phosphodiesterase YP_002408982.1 3177991 D 585057 CDS YP_002408983.1 218701354 7150115 3179695..3180555 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type m : membrane component; nucleoside channel phage T6/colicin K receptor 3180555 tsx 7150115 tsx Escherichia coli IAI39 nucleoside channel phage T6/colicin K receptor YP_002408983.1 3179695 D 585057 CDS YP_002408984.1 218701355 7153050 complement(3180772..3183204) 1 NC_011750.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 3183204 metL 7153050 metL Escherichia coli IAI39 bifunctional aspartate kinase II/homoserine dehydrogenase II YP_002408984.1 3180772 R 585057 CDS YP_002408985.1 218701356 7152060 complement(3183207..3184367) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87326410, 90148970, 3307782, 6361020, 9843488; Product type e : enzyme; cystathionine gamma-synthase, PLP-dependent 3184367 metB 7152060 metB Escherichia coli IAI39 cystathionine gamma-synthase, PLP-dependent YP_002408985.1 3183207 R 585057 CDS YP_002408986.1 218701357 7152051 3184506..3184961 1 NC_011750.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ 3184961 metJ 7152051 metJ Escherichia coli IAI39 transcriptional repressor protein MetJ YP_002408986.1 3184506 D 585057 CDS YP_002408987.1 218701358 7152058 3185021..3185629 1 NC_011750.1 member of the NlpC/P60 superfamily of peptidases; putative peptidoglycan peptidase 3185629 yiiX 7152058 yiiX Escherichia coli IAI39 putative peptidoglycan peptidase YP_002408987.1 3185021 D 585057 CDS YP_002408988.1 218701359 7154245 complement(3185690..3185902) 1 NC_011750.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 3185902 rpmE 7154245 rpmE Escherichia coli IAI39 50S ribosomal protein L31 YP_002408988.1 3185690 R 585057 CDS YP_002408989.1 218701360 7152698 3186105..3188303 1 NC_011750.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 3188303 priA 7152698 priA Escherichia coli IAI39 primosome assembly protein PriA YP_002408989.1 3186105 D 585057 CDS YP_002408990.1 218701361 7152476 3188459..3189484 1 NC_011750.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR 3189484 cytR 7152476 cytR Escherichia coli IAI39 DNA-binding transcriptional regulator CytR YP_002408990.1 3188459 D 585057 CDS YP_002408991.1 218701362 7151073 3189576..3190535 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9282742, 93285993, 8509333; Product type cp : cell process; essential cell division protein FtsN 3190535 ftsN 7151073 ftsN Escherichia coli IAI39 essential cell division protein FtsN YP_002408991.1 3189576 D 585057 CDS YP_002408992.1 218701363 7151440 3190627..3191157 1 NC_011750.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 3191157 hslV 7151440 hslV Escherichia coli IAI39 ATP-dependent protease peptidase subunit YP_002408992.1 3190627 D 585057 CDS YP_002408993.1 218701364 7151684 3191167..3192498 1 NC_011750.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 3192498 hslU 7151684 hslU Escherichia coli IAI39 ATP-dependent protease ATP-binding subunit HslU YP_002408993.1 3191167 D 585057 CDS YP_002408994.1 218701365 7151683 3192565..3193491 1 NC_011750.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 3193491 menA 7151683 menA Escherichia coli IAI39 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_002408994.1 3192565 D 585057 CDS YP_002408995.1 218701366 7152043 3193584..3194069 1 NC_011750.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 3194069 rraA 7152043 rraA Escherichia coli IAI39 ribonuclease activity regulator protein RraA YP_002408995.1 3193584 D 585057 CDS YP_002408996.1 218701367 7152734 3194117..3194803 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3194803 7152734 ECIAI39_3066 Escherichia coli IAI39 hypothetical protein YP_002408996.1 3194117 D 585057 CDS YP_002408997.1 218701368 7150116 3194836..3195552 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3195552 7150116 ECIAI39_3067 Escherichia coli IAI39 hypothetical protein YP_002408997.1 3194836 D 585057 CDS YP_002408998.1 218701369 7150117 complement(3195591..3195836) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3195836 yiiU 7150117 yiiU Escherichia coli IAI39 hypothetical protein YP_002408998.1 3195591 R 585057 CDS YP_002408999.1 218701370 7154244 3196261..3197106 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12629974, 12948772, 14646142, 15004242, 90094250, 92210584, 11039922, 11101882, 11226336, 11964478, 1372899, 2544860, 6998951; Product type t : transporter; glycerol facilitator 3197106 glpF 7154244 glpF Escherichia coli IAI39 glycerol facilitator YP_002408999.1 3196261 D 585057 CDS YP_002409000.1 218701371 7151541 3197129..3198637 1 NC_011750.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 3198637 glpK 7151541 glpK Escherichia coli IAI39 glycerol kinase YP_002409000.1 3197129 D 585057 CDS YP_002409001.1 218701372 7151543 3198772..3199782 1 NC_011750.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 3199782 glpX 7151543 glpX Escherichia coli IAI39 fructose 1,6-bisphosphatase II YP_002409001.1 3198772 D 585057 CDS YP_002409002.1 218701373 7151547 3199879..3200625 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93194782, 94092163, 95050480, 95362685, 1400248, 2834327, 7961651, 8449868, 9149148; Product type e : enzyme; ferredoxin-NADP reductase 3200625 fpr 7151547 fpr Escherichia coli IAI39 ferredoxin-NADP reductase YP_002409002.1 3199879 D 585057 CDS YP_002409003.1 218701374 7151406 complement(3200630..3201058) 1 NC_011750.1 with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 3201058 yiiT 7151406 yiiT Escherichia coli IAI39 universal stress protein UspD YP_002409003.1 3200630 R 585057 CDS YP_002409004.1 218701375 7154243 complement(3201085..3201384) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3201384 yiiS 7154243 yiiS Escherichia coli IAI39 hypothetical protein YP_002409004.1 3201085 R 585057 CDS YP_002409005.1 218701376 7154242 complement(3201596..3202036) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3202036 yiiR 7154242 yiiR Escherichia coli IAI39 hypothetical protein YP_002409005.1 3201596 R 585057 CDS YP_002409006.1 218701377 7154241 3202137..3202736 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3202736 yiiQ 7154241 yiiQ Escherichia coli IAI39 hypothetical protein YP_002409006.1 3202137 D 585057 CDS YP_002409007.1 218701378 7154240 3202844..3203611 1 NC_011750.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 3203611 tpiA 7154240 tpiA Escherichia coli IAI39 triosephosphate isomerase YP_002409007.1 3202844 D 585057 CDS YP_002409008.1 218701379 7153013 complement(3203666..3204421) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86008270, 2995360, 3158524; Product type e : enzyme; CDP-diacylglycerol pyrophosphatase 3204421 cdh 7153013 cdh Escherichia coli IAI39 CDP-diacylglycerol pyrophosphatase YP_002409008.1 3203666 R 585057 CDS YP_002409009.1 218701380 7150921 complement(3204528..3205517) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91161616, 2002055, 3158524, 8774726, 9298646; Product type t : transporter; sulfate transporter subunit 3205517 sbp 7150921 sbp Escherichia coli IAI39 sulfate transporter subunit YP_002409009.1 3204528 R 585057 CDS YP_002409010.1 218701381 7152809 complement(3205837..3206799) 1 NC_011750.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 3206799 pfkA 7152809 pfkA Escherichia coli IAI39 6-phosphofructokinase YP_002409010.1 3205837 R 585057 CDS YP_002409011.1 218701382 7152370 complement(3206980..3207882) 1 NC_011750.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F 3207882 fieF 7152370 fieF Escherichia coli IAI39 ferrous iron efflux protein F YP_002409011.1 3206980 R 585057 CDS YP_002409012.1 218701383 7151325 complement(3208031..3208531) 1 NC_011750.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; periplasmic repressor CpxP 3208531 cpxP 7151325 cpxP Escherichia coli IAI39 periplasmic repressor CpxP YP_002409012.1 3208031 R 585057 CDS YP_002409013.1 218701384 7150990 3208681..3209379 1 NC_011750.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR 3209379 cpxR 7150990 cpxR Escherichia coli IAI39 DNA-binding transcriptional regulator CpxR YP_002409013.1 3208681 D 585057 CDS YP_002409014.1 218701385 7150991 3209376..3210749 1 NC_011750.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein 3210749 cpxA 7150991 cpxA Escherichia coli IAI39 two-component sensor protein YP_002409014.1 3209376 D 585057 CDS YP_002409015.1 218701386 7150989 complement(3210854..3211528) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3211528 yiiM 7150989 yiiM Escherichia coli IAI39 hypothetical protein YP_002409015.1 3210854 R 585057 CDS YP_002409016.1 218701387 7154239 complement(3211677..3212660) 1 NC_011750.1 transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 3212660 kdgT 7154239 kdgT Escherichia coli IAI39 2-keto-3-deoxygluconate permease YP_002409016.1 3211677 R 585057 CDS YP_002409017.1 218701388 7151879 complement(3212920..3213540) 1 NC_011750.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 3213540 sodA 7151879 sodA Escherichia coli IAI39 superoxide dismutase YP_002409017.1 3212920 R 585057 CDS YP_002409018.1 218701389 7152870 3213825..3214859 1 NC_011750.1 transports L-rhamnose and L-lyxose into the cell; rhamnose-proton symporter 3214859 rhaT 7152870 rhaT Escherichia coli IAI39 rhamnose-proton symporter YP_002409018.1 3213825 D 585057 CDS YP_002409019.1 218701390 7152617 complement(3214856..3215794) 1 NC_011750.1 activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR 3215794 rhaR 7152617 rhaR Escherichia coli IAI39 transcriptional activator RhaR YP_002409019.1 3214856 R 585057 CDS YP_002409020.1 218701391 7152615 complement(3215778..3216614) 1 NC_011750.1 activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 3216614 rhaS 7152615 rhaS Escherichia coli IAI39 transcriptional activator RhaS YP_002409020.1 3215778 R 585057 CDS YP_002409021.1 218701392 7152616 3216902..3218371 1 NC_011750.1 catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase 3218371 rhaB 7152616 rhaB Escherichia coli IAI39 rhamnulokinase YP_002409021.1 3216902 D 585057 CDS YP_002409022.1 218701393 7152613 3218368..3219627 1 NC_011750.1 catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase 3219627 rhaA 7152613 rhaA Escherichia coli IAI39 L-rhamnose isomerase YP_002409022.1 3218368 D 585057 CDS YP_002409023.1 218701394 7152612 3219693..3220223 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 3220223 7152612 ECIAI39_3093 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002409023.1 3219693 D 585057 CDS YP_002409024.1 218701395 7150118 3220328..3221050 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 3221050 7150118 ECIAI39_3094 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002409024.1 3220328 D 585057 CDS YP_002409025.1 218701396 7150119 3221145..3221969 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90128204, 93374854, 8396120; Product type e : enzyme; rhamnulose-1-phosphate aldolase 3221969 rhaD 7150119 rhaD Escherichia coli IAI39 rhamnulose-1-phosphate aldolase YP_002409025.1 3221145 D 585057 CDS YP_002409026.1 218701397 7152614 3221979..3222293 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15060078; Product type e : enzyme; L-rhamnose mutarotase 3222293 yiiL 7152614 yiiL Escherichia coli IAI39 L-rhamnose mutarotase YP_002409026.1 3221979 D 585057 CDS YP_002409027.1 218701398 7154238 complement(3222334..3223728) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative glycoporin 3223728 7154238 ECIAI39_3097 Escherichia coli IAI39 putative glycoporin YP_002409027.1 3222334 R 585057 CDS YP_002409028.1 218701399 7150120 3224205..3224651 1 NC_011750.1 with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system; putative fructose-like phosphotransferase system subunit EIIA 3224651 frvA 7150120 frvA Escherichia coli IAI39 putative fructose-like phosphotransferase system subunit EIIA YP_002409028.1 3224205 D 585057 CDS YP_002409029.1 218701400 7151423 3224662..3226113 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 94290319; Product type t : transporter; putative PTS system transporter subunits IIBC 3226113 frvB 7151423 frvB Escherichia coli IAI39 putative PTS system transporter subunits IIBC YP_002409029.1 3224662 D 585057 CDS YP_002409030.1 218701401 7151424 3226103..3227173 1 NC_011750.1 with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars; putative fructose-specific phosphotransferase system protein FrvX 3227173 frvX 7151424 frvX Escherichia coli IAI39 putative fructose-specific phosphotransferase system protein FrvX YP_002409030.1 3226103 D 585057 CDS YP_002409031.1 218701402 7151426 3227173..3228921 1 NC_011750.1 putative repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system; putative frv operon regulatory protein 3228921 frvR 7151426 frvR Escherichia coli IAI39 putative frv operon regulatory protein YP_002409031.1 3227173 D 585057 CDS YP_002409032.1 218701403 7151425 complement(3228971..3230026) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3230026 yiiG 7151425 yiiG Escherichia coli IAI39 hypothetical protein YP_002409032.1 3228971 R 585057 CDS YP_002409033.1 218701404 7154237 complement(3230179..3231012) 1 NC_011750.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 3231012 fdhD 7154237 fdhD Escherichia coli IAI39 formate dehydrogenase accessory protein YP_002409033.1 3230179 R 585057 CDS YP_002409034.1 218701405 7151283 3231206..3234256 1 NC_011750.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-O, large subunit 3234256 fdoG 7151283 fdoG Escherichia coli IAI39 formate dehydrogenase-O, large subunit YP_002409034.1 3231206 D 585057 CDS YP_002409035.1 218701406 7151289 3234269..3235171 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91317715, 8522521, 9852007; Product type c : carrier; formate dehydrogenase-O, Fe-S subunit 3235171 fdoH 7151289 fdoH Escherichia coli IAI39 formate dehydrogenase-O, Fe-S subunit YP_002409035.1 3234269 D 585057 CDS YP_002409036.1 218701407 7151290 3235168..3235803 1 NC_011750.1 cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma 3235803 fdoI 7151290 fdoI Escherichia coli IAI39 formate dehydrogenase-O subunit gamma YP_002409036.1 3235168 D 585057 CDS YP_002409037.1 218701408 7151291 3235800..3236729 1 NC_011750.1 required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 3236729 fdhE 7151291 fdhE Escherichia coli IAI39 formate dehydrogenase accessory protein FdhE YP_002409037.1 3235800 D 585057 CDS YP_002409038.1 218701409 7151284 complement(3237058..3237300) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3237300 yiiF 7151284 yiiF Escherichia coli IAI39 hypothetical protein YP_002409038.1 3237058 R 585057 CDS YP_002409039.1 218701410 7154236 complement(3237520..3237738) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3237738 yiiE 7154236 yiiE Escherichia coli IAI39 putative transcriptional regulator YP_002409039.1 3237520 R 585057 CDS YP_002409040.1 218701411 7154235 complement(3238434..3240287) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3240287 7154235 ECIAI39_3111 Escherichia coli IAI39 hypothetical protein YP_002409040.1 3238434 R 585057 CDS YP_002409041.1 218701412 7150121 complement(3240664..3241653) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase 3241653 yiiD 7150121 yiiD Escherichia coli IAI39 putative acetyltransferase YP_002409041.1 3240664 R 585057 CDS YP_002409042.1 218701413 7154234 complement(3241650..3242087) 1 NC_011750.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 3242087 dtd 7154234 dtd Escherichia coli IAI39 D-tyrosyl-tRNA(Tyr) deacylase YP_002409042.1 3241650 R 585057 CDS YP_002409043.1 218701414 7151185 complement(3242084..3242956) 1 NC_011750.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 3242956 rbn 7151185 rbn Escherichia coli IAI39 ribonuclease BN YP_002409043.1 3242084 R 585057 CDS YP_002409044.1 218701415 7152570 complement(3242950..3243549) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; phosphatase 3243549 yihX 7152570 yihX Escherichia coli IAI39 phosphatase YP_002409044.1 3242950 R 585057 CDS YP_002409045.1 218701416 7154233 complement(3243648..3244433) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3244433 yihW 7154233 yihW Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002409045.1 3243648 R 585057 CDS YP_002409046.1 218701417 7154232 complement(3244467..3245363) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar kinase 3245363 yihV 7154232 yihV Escherichia coli IAI39 putative sugar kinase YP_002409046.1 3244467 R 585057 CDS YP_002409047.1 218701418 7154231 3245531..3246427 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 3246427 yihU 7154231 yihU Escherichia coli IAI39 putative oxidoreductase YP_002409047.1 3245531 D 585057 CDS YP_002409048.1 218701419 7154230 3246451..3247329 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldolase 3247329 yihT 7154230 yihT Escherichia coli IAI39 putative aldolase YP_002409048.1 3246451 D 585057 CDS YP_002409049.1 218701420 7154229 3247345..3248529 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glucosamine isomerase 3248529 yihS 7154229 yihS Escherichia coli IAI39 putative glucosamine isomerase YP_002409049.1 3247345 D 585057 CDS YP_002409050.1 218701421 7154228 3248588..3249499 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldose-1-epimerase 3249499 yihR 7154228 yihR Escherichia coli IAI39 putative aldose-1-epimerase YP_002409050.1 3248588 D 585057 CDS YP_002409051.1 218701422 7154227 3249697..3251733 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15294295; Product type e : enzyme; alpha-glucosidase 3251733 yihQ 7154227 yihQ Escherichia coli IAI39 alpha-glucosidase YP_002409051.1 3249697 D 585057 CDS YP_002409052.1 218701423 7154226 3251746..3253164 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3253164 yihP 7154226 yihP Escherichia coli IAI39 putative transporter YP_002409052.1 3251746 D 585057 CDS YP_002409053.1 218701424 7154225 3253207..3254610 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3254610 yihO 7154225 yihO Escherichia coli IAI39 putative transporter YP_002409053.1 3253207 D 585057 CDS YP_002409054.1 218701425 7154224 3254677..3255369 1 NC_011750.1 porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown; outer membrane porin L 3255369 ompL 7154224 ompL Escherichia coli IAI39 outer membrane porin L YP_002409054.1 3254677 D 585057 CDS YP_002409055.1 218701426 7152294 complement(3255461..3256726) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3256726 yihN 7152294 yihN Escherichia coli IAI39 putative transporter YP_002409055.1 3255461 R 585057 CDS YP_002409056.1 218701427 7154223 complement(3256828..3257808) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar phosphate isomerase 3257808 yihM 7154223 yihM Escherichia coli IAI39 putative sugar phosphate isomerase YP_002409056.1 3256828 R 585057 CDS YP_002409057.1 218701428 7154222 complement(3257816..3258526) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3258526 yihL 7154222 yihL Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002409057.1 3257816 R 585057 CDS YP_002409058.1 218701429 7154221 3258783..3260129 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element 3260129 insG 7154221 insG Escherichia coli IAI39 putative IS4 transposase; KpLE2 phage-like element YP_002409058.1 3258783 D 585057 CDS YP_002409059.1 218701430 7151813 complement(3260181..3262004) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9642082, 7783627, 9298646, 9622352; Product type f : factor; GTP-binding protein 3262004 bipA 7151813 bipA Escherichia coli IAI39 GTP-binding protein YP_002409059.1 3260181 R 585057 CDS YP_002409060.1 218701431 7150868 3262377..3263786 1 NC_011750.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase 3263786 glnA 7150868 glnA Escherichia coli IAI39 glutamine synthetase YP_002409060.1 3262377 D 585057 CDS YP_002409061.1 218701432 7151523 3263960..3265009 1 NC_011750.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) 3265009 glnL 7151523 glnL Escherichia coli IAI39 nitrogen regulation protein NR(II) YP_002409061.1 3263960 D 585057 CDS YP_002409062.1 218701433 7151530 3265021..3266430 1 NC_011750.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) 3266430 glnG 7151530 glnG Escherichia coli IAI39 nitrogen regulation protein NR(I) YP_002409062.1 3265021 D 585057 CDS YP_002409063.1 218701434 7151527 complement(3266880..3268253) 1 NC_011750.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3268253 hemN 7151527 hemN Escherichia coli IAI39 coproporphyrinogen III oxidase YP_002409063.1 3266880 R 585057 CDS YP_002409064.1 218701435 7151633 complement(3268442..3268951) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3268951 yihI 7151633 yihI Escherichia coli IAI39 hypothetical protein YP_002409064.1 3268442 R 585057 CDS YP_002409065.1 218701436 7151023 3269569..3270165 1 NC_011750.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 3270165 engB 7151023 engB Escherichia coli IAI39 ribosome biogenesis GTP-binding protein YsxC YP_002409065.1 3269569 D 585057 CDS YP_002409066.1 218701437 7152886 complement(3270547..3273333) 1 NC_011750.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 3273333 polA 7152886 polA Escherichia coli IAI39 DNA polymerase I YP_002409066.1 3270547 R 585057 CDS YP_002409067.1 218701438 7152439 3273697..3274629 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyltransferase 3274629 yihG 7152439 yihG Escherichia coli IAI39 putative acyltransferase YP_002409067.1 3273697 D 585057 CDS YP_002409068.1 218701439 7154219 complement(3274670..3276100) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3276100 yihF 7154219 yihF Escherichia coli IAI39 hypothetical protein YP_002409068.1 3274670 R 585057 CDS YP_002409069.1 218701440 7154218 complement(3276255..3276881) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12498799, 93264419, 94016574, 94206930, 99298180, 10210188, 1429594, 1740115, 1934062, 8413591, 8494885, 8521518, 9194175, 9298646, 9300489, 9572841, 9600841, 9655827; Product type e : enzyme; periplasmic protein disulfide isomerase I 3276881 dsbA 7154218 dsbA Escherichia coli IAI39 periplasmic protein disulfide isomerase I YP_002409069.1 3276255 R 585057 CDS YP_002409070.1 218701441 7151172 complement(3276898..3277884) 1 NC_011750.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 3277884 yihE 7151172 yihE Escherichia coli IAI39 serine/threonine protein kinase YP_002409070.1 3276898 R 585057 CDS YP_002409071.1 218701442 7154217 complement(3277961..3278230) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3278230 yihD 7154217 yihD Escherichia coli IAI39 hypothetical protein YP_002409071.1 3277961 R 585057 CDS YP_002409072.1 218701443 7154216 3278300..3278884 1 NC_011750.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA 3278884 mobA 7154216 mobA Escherichia coli IAI39 molybdopterin-guanine dinucleotide biosynthesis protein MobA YP_002409072.1 3278300 D 585057 CDS YP_002409073.1 218701444 7152100 3278881..3279393 1 NC_011750.1 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; molybdopterin-guanine dinucleotide biosynthesis protein B 3279393 mobB 7152100 mobB Escherichia coli IAI39 molybdopterin-guanine dinucleotide biosynthesis protein B YP_002409073.1 3278881 D 585057 CDS YP_002409074.1 218701445 7149775 complement(3284967..3285512) 1 NC_011750.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 3285512 hemG 7149775 hemG Escherichia coli IAI39 protoporphyrinogen oxidase YP_002409074.1 3284967 R 585057 CDS YP_002409075.1 218701446 7151630 complement(3285524..3286975) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100357, 2243799, 7896723; Product type t : transporter; potassium transporter 3286975 trkH 7151630 trkH Escherichia coli IAI39 potassium transporter YP_002409075.1 3285524 R 585057 CDS YP_002409076.1 218701447 7153024 complement(3287014..3287628) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15103642; Product type pf : putative factor; hypothetical protein 3287628 yigZ 7153024 yigZ Escherichia coli IAI39 hypothetical protein YP_002409076.1 3287014 R 585057 CDS YP_002409077.1 218701448 7154214 complement(3287628..3288959) 1 NC_011750.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 3288959 pepQ 7154214 pepQ Escherichia coli IAI39 proline dipeptidase YP_002409077.1 3287628 R 585057 CDS YP_002409078.1 218701449 7152367 3289149..3291338 1 NC_011750.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha 3291338 fadB 7152367 fadB Escherichia coli IAI39 multifunctional fatty acid oxidation complex subunit alpha YP_002409078.1 3289149 D 585057 CDS YP_002409079.1 218701450 7151273 3291348..3292511 1 NC_011750.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase 3292511 fadA 7151273 fadA Escherichia coli IAI39 3-ketoacyl-CoA thiolase YP_002409079.1 3291348 D 585057 CDS YP_002409080.1 218701451 7151272 complement(3292621..3293343) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 3293343 7151272 ECIAI39_3151 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002409080.1 3292621 R 585057 CDS YP_002409081.1 218701452 7150122 complement(3293448..3293978) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 3293978 7150122 ECIAI39_3152 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002409081.1 3293448 R 585057 CDS YP_002409082.1 218701453 7150123 complement(3294138..3294839) 1 NC_011750.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 3294839 fre 7150123 fre Escherichia coli IAI39 FMN reductase YP_002409082.1 3294138 R 585057 CDS YP_002409083.1 218701454 7151412 complement(3294885..3296378) 1 NC_011750.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate decarboxylase 3296378 ubiD 7151412 ubiD Escherichia coli IAI39 3-octaprenyl-4-hydroxybenzoate decarboxylase YP_002409083.1 3294885 R 585057 CDS YP_002409084.1 218701455 7153071 3296545..3297033 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92011415, 92250420, 92261317, 1584020, 12007406; Product type r : regulator; transcriptional activator RfaH 3297033 rfaH 7153071 rfaH Escherichia coli IAI39 transcriptional activator RfaH YP_002409084.1 3296545 D 585057 CDS YP_002409085.1 218701456 7152602 complement(3297030..3297812) 1 NC_011750.1 magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD 3297812 tatD 7152602 tatD Escherichia coli IAI39 DNase TatD YP_002409085.1 3297030 R 585057 CDS YP_002409086.1 218701457 7152946 complement(3297854..3298630) 1 NC_011750.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 3298630 tatC 7152946 tatC Escherichia coli IAI39 twin-arginine protein translocation system subunit TatC YP_002409086.1 3297854 R 585057 CDS YP_002409087.1 218701458 7152945 complement(3298633..3299148) 1 NC_011750.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 3299148 tatB 7152945 tatB Escherichia coli IAI39 sec-independent translocase YP_002409087.1 3298633 R 585057 CDS YP_002409088.1 218701459 7152944 complement(3299152..3299421) 1 NC_011750.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A 3299421 tatA 7152944 tatA Escherichia coli IAI39 twin arginine translocase protein A YP_002409088.1 3299152 R 585057 CDS YP_002409089.1 218701460 7152943 complement(3299500..3301140) 1 NC_011750.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; putative ubiquinone biosynthesis protein UbiB 3301140 ubiB 7152943 ubiB Escherichia coli IAI39 putative ubiquinone biosynthesis protein UbiB YP_002409089.1 3299500 R 585057 CDS YP_002409090.1 218701461 7153069 complement(3301137..3301742) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3301742 yigP 7153069 yigP Escherichia coli IAI39 hypothetical protein YP_002409090.1 3301137 R 585057 CDS YP_002409091.1 218701462 7154213 complement(3301756..3302511) 1 NC_011750.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 3302511 ubiE 7154213 ubiE Escherichia coli IAI39 ubiquinone/menaquinone biosynthesis methyltransferase YP_002409091.1 3301756 R 585057 CDS YP_002409092.1 218701463 7153072 complement(3302606..3304033) 1 NC_011750.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 3304033 rmuC 7153072 rmuC Escherichia coli IAI39 DNA recombination protein RmuC YP_002409092.1 3302606 R 585057 CDS YP_002409093.1 218701464 7152650 3304163..3305017 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3305017 7152650 ECIAI39_3164 Escherichia coli IAI39 putative transcriptional regulator YP_002409093.1 3304163 D 585057 CDS YP_002409094.1 218701465 7150124 3305041..3306045 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; acidic carbohydrate kinase 3306045 7150124 ECIAI39_3165 Escherichia coli IAI39 acidic carbohydrate kinase YP_002409094.1 3305041 D 585057 CDS YP_002409095.1 218701466 7150127 3306689..3307663 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative periplasmic binding protein 3307663 7150127 ECIAI39_3168 Escherichia coli IAI39 putative periplasmic binding protein YP_002409095.1 3306689 D 585057 CDS YP_002409096.1 218701467 7150128 3307677..3308186 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease subunit 3308186 7150128 ECIAI39_3169 Escherichia coli IAI39 putative permease subunit YP_002409096.1 3307677 D 585057 CDS YP_002409097.1 218701468 7150129 3308199..3309689 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3309689 7150129 ECIAI39_3170 Escherichia coli IAI39 hypothetical protein YP_002409097.1 3308199 D 585057 CDS YP_002409098.1 218701469 7150130 complement(3309723..3310493) 1 NC_011750.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 3310493 udp 7150130 udp Escherichia coli IAI39 uridine phosphorylase YP_002409098.1 3309723 R 585057 CDS YP_002409099.1 218701470 7153079 3310683..3311561 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12676709; Product type pe : putative enzyme; putative hydrolase 3311561 ysgA 7153079 ysgA Escherichia coli IAI39 putative hydrolase YP_002409099.1 3310683 D 585057 CDS YP_002409100.1 218701471 7154568 3311954..3313138 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3313138 7154568 ECIAI39_3173 Escherichia coli IAI39 hypothetical protein YP_002409100.1 3311954 D 585057 CDS YP_002409101.1 218701472 7150131 complement(3313020..3313910) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 3313910 7150131 ECIAI39_3174 Escherichia coli IAI39 transposase ORF B, IS629 YP_002409101.1 3313020 R 585057 CDS YP_002409102.1 218701473 7150132 complement(3313907..3314233) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 3314233 7150132 ECIAI39_3175 Escherichia coli IAI39 transposase ORF A, IS629 YP_002409102.1 3313907 R 585057 CDS YP_002409103.1 218701474 7150133 complement(3314366..3315271) 1 NC_011750.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3315271 insD 7150133 insD Escherichia coli IAI39 insertion element IS2 transposase InsD YP_002409103.1 3314366 R 585057 CDS YP_002409104.1 218701475 7151806 complement(3315229..3315639) 1 NC_011750.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3315639 insC 7151806 insC Escherichia coli IAI39 insertion sequence 2 OrfA protein YP_002409104.1 3315229 R 585057 CDS YP_002409105.1 218701476 7151803 3315551..3315643 1 NC_011750.1 hypothetical protein 3315643 7151803 ECIAI39_3178 Escherichia coli IAI39 hypothetical protein YP_002409105.1 3315551 D 585057 CDS YP_002409106.1 218701477 7150134 3315711..3315986 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3315986 7150134 ECIAI39_3179 Escherichia coli IAI39 hypothetical protein YP_002409106.1 3315711 D 585057 CDS YP_002409107.1 218701478 7150135 complement(3316155..3318416) 1 NC_011750.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 3318416 metE 7150135 metE Escherichia coli IAI39 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase YP_002409107.1 3316155 R 585057 CDS YP_002409108.1 218701479 7152053 3318534..3319487 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90384950, 96303520, 2205852, 2643109; Product type r : regulator; DNA-binding transcriptional activator, homocysteine-binding 3319487 metR 7152053 metR Escherichia coli IAI39 DNA-binding transcriptional activator, homocysteine-binding YP_002409108.1 3318534 D 585057 CDS YP_002409109.1 218701480 7152063 complement(3319375..3320274) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3320274 yigM 7152063 yigM Escherichia coli IAI39 hypothetical protein YP_002409109.1 3319375 R 585057 CDS YP_002409110.1 218701481 7154212 complement(3320350..3321150) 1 NC_011750.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; putative sugar phosphatase 3321150 yigL 7154212 yigL Escherichia coli IAI39 putative sugar phosphatase YP_002409110.1 3320350 R 585057 CDS YP_002409111.1 218701482 7154211 complement(3321158..3322180) 1 NC_011750.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 3322180 pldB 7154211 pldB Escherichia coli IAI39 lysophospholipase L2 YP_002409111.1 3321158 R 585057 CDS YP_002409112.1 218701483 7152426 3322291..3322911 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99313167, 10386596; Product type t : transporter; homoserine/homoserine lactone efflux protein 3322911 rhtB 7152426 rhtB Escherichia coli IAI39 homoserine/homoserine lactone efflux protein YP_002409112.1 3322291 D 585057 CDS YP_002409113.1 218701484 7152623 complement(3322972..3323592) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99313167, 10386596, 3027506; Product type t : transporter; threonine efflux system 3323592 rhtC 7152623 rhtC Escherichia coli IAI39 threonine efflux system YP_002409113.1 3322972 R 585057 CDS YP_002409114.1 218701485 7152624 complement(3323656..3325485) 1 NC_011750.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ 3325485 recQ 7152624 recQ Escherichia coli IAI39 ATP-dependent DNA helicase RecQ YP_002409114.1 3323656 R 585057 CDS YP_002409115.1 218701486 7152596 complement(3325610..3326479) 1 NC_011750.1 catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 3326479 pldA 7152596 pldA Escherichia coli IAI39 phospholipase A YP_002409115.1 3325610 R 585057 CDS YP_002409116.1 218701487 7152425 3326644..3327111 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3327111 yigI 7152425 yigI Escherichia coli IAI39 hypothetical protein YP_002409116.1 3326644 D 585057 CDS YP_002409117.1 218701488 7154210 3327163..3328053 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative chloramphenicol resistance permease 3328053 rarD 7154210 rarD Escherichia coli IAI39 putative chloramphenicol resistance permease YP_002409117.1 3327163 D 585057 CDS YP_002409118.1 218701489 7152566 3328542..3328922 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9868784; Product type pm : putative membrane component; hypothetical protein 3328922 yigF 7152566 yigF Escherichia coli IAI39 hypothetical protein YP_002409118.1 3328542 D 585057 CDS YP_002409119.1 218701490 7154209 complement(3328965..3329168) 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3329168 7154209 ECIAI39_3192 Escherichia coli IAI39 hypothetical protein YP_002409119.1 3328965 R 585057 CDS YP_002409120.1 218701491 7150136 3329292..3330146 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3330146 7150136 ECIAI39_3193 Escherichia coli IAI39 hypothetical protein YP_002409120.1 3329292 D 585057 CDS YP_002409121.1 218701492 7150137 3330143..3330640 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3330640 7150137 ECIAI39_3194 Escherichia coli IAI39 hypothetical protein YP_002409121.1 3330143 D 585057 CDS YP_002409122.1 218701493 7150138 complement(3330676..3331626) 1 NC_011750.1 responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 3331626 corA 7150138 corA Escherichia coli IAI39 magnesium/nickel/cobalt transporter CorA YP_002409122.1 3330676 R 585057 CDS YP_002409123.1 218701494 7154208 complement(3332345..3333691) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element 3333691 insG 7154208 insG Escherichia coli IAI39 putative IS4 transposase; KpLE2 phage-like element YP_002409123.1 3332345 R 585057 CDS YP_002409124.1 218701495 7151814 complement(3333799..3335097) 1 NC_011750.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 3335097 eno 7151814 eno Escherichia coli IAI39 phosphopyruvate hydratase YP_002409124.1 3333799 R 585057 CDS YP_002409125.1 218701496 7151221 complement(3335184..3336821) 1 NC_011750.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 3336821 pyrG 7151221 pyrG Escherichia coli IAI39 CTP synthetase YP_002409125.1 3335184 R 585057 CDS YP_002409126.1 218701497 7152553 complement(3337049..3337840) 1 NC_011750.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase 3337840 mazG 7152553 mazG Escherichia coli IAI39 nucleoside triphosphate pyrophosphohydrolase YP_002409126.1 3337049 R 585057 CDS YP_002409127.1 218701498 7152018 complement(3337912..3338247) 1 NC_011750.1 MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA 3338247 chpA 7152018 chpA Escherichia coli IAI39 toxin ChpA YP_002409127.1 3337912 R 585057 CDS YP_002409128.1 218701499 7150940 complement(3338247..3338495) 1 NC_011750.1 part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE 3338495 chpR 7150940 chpR Escherichia coli IAI39 antitoxin MazE YP_002409128.1 3338247 R 585057 CDS YP_002409129.1 218701500 7150942 complement(3338573..3340807) 1 NC_011750.1 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase 3340807 relA 7150942 relA Escherichia coli IAI39 GDP/GTP pyrophosphokinase YP_002409129.1 3338573 R 585057 CDS YP_002409130.1 218701501 7152599 complement(3340855..3342156) 1 NC_011750.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 3342156 rumA 7152599 rumA Escherichia coli IAI39 23S rRNA 5-methyluridine methyltransferase YP_002409130.1 3340855 R 585057 CDS YP_002409131.1 218701502 7150836 complement(3343456..3344178) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 3344178 7150836 ECIAI39_3206 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002409131.1 3343456 R 585057 CDS YP_002409132.1 218701503 7150139 complement(3344283..3344813) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 3344813 7150139 ECIAI39_3207 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002409132.1 3344283 R 585057 CDS YP_002409133.1 218701504 7150837 complement(3346636..3347976) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20233700, 9772162, 10762278, 13971911; Product type e : enzyme; (D)-glucarate dehydratase 1 3347976 gudD 7150837 gudD Escherichia coli IAI39 (D)-glucarate dehydratase 1 YP_002409133.1 3346636 R 585057 CDS YP_002409134.1 218701505 7151600 complement(3347997..3349337) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9772162; Product type e : enzyme; glucarate dehydratase 3349337 gudX 7151600 gudX Escherichia coli IAI39 glucarate dehydratase YP_002409134.1 3347997 R 585057 CDS YP_002409135.1 218701506 7151602 complement(3349339..3350691) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10762278; Product type pt : putative transporter; putative D-glucarate transporter 3350691 gudP 7151602 gudP Escherichia coli IAI39 putative D-glucarate transporter YP_002409135.1 3349339 R 585057 CDS YP_002409136.1 218701507 7151601 complement(3351126..3351575) 1 NC_011750.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 3351575 yqcA 7151601 yqcA Escherichia coli IAI39 flavodoxin YP_002409136.1 3351126 R 585057 CDS YP_002409137.1 218701508 7154499 complement(3351593..3352375) 1 NC_011750.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C 3352375 truC 7154499 truC Escherichia coli IAI39 tRNA pseudouridine synthase C YP_002409137.1 3351593 R 585057 CDS YP_002409138.1 218701509 7153041 complement(3352375..3352704) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3352704 yqcC 7153041 yqcC Escherichia coli IAI39 hypothetical protein YP_002409138.1 3352375 R 585057 CDS YP_002409139.1 218701510 7151022 complement(3353326..3353871) 1 NC_011750.1 putative SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd 3353871 syd 7151022 syd Escherichia coli IAI39 SecY interacting protein Syd YP_002409139.1 3353326 R 585057 CDS YP_002409140.1 218701511 7152934 3353939..3354787 1 NC_011750.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 3354787 queF 7152934 queF Escherichia coli IAI39 7-cyano-7-deazaguanine reductase YP_002409140.1 3353939 D 585057 CDS YP_002409141.1 218701512 7152562 3354899..3356263 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3356263 ygdH 7152562 ygdH Escherichia coli IAI39 hypothetical protein YP_002409141.1 3354899 D 585057 CDS YP_002409142.1 218701513 7153946 3356819..3358108 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8752353, 8026499; Product type pt : putative transporter; putative serine transporter 3358108 sdaC 7153946 sdaC Escherichia coli IAI39 putative serine transporter YP_002409142.1 3356819 D 585057 CDS YP_002409143.1 218701514 7152812 3358166..3359533 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91193203, 93215657, 8385012; Product type e : enzyme; L-serine deaminase II 3359533 sdaB 7152812 sdaB Escherichia coli IAI39 L-serine deaminase II YP_002409143.1 3358166 D 585057 CDS YP_002409144.1 218701515 7152811 3359555..3360400 1 NC_011750.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 3360400 xni 7152811 xni Escherichia coli IAI39 exonuclease IX YP_002409144.1 3359555 D 585057 CDS YP_002409145.1 218701516 7151259 complement(3360505..3361656) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 89291720, 2553671, 2661535, 2664711, 8385012; Product type e : enzyme; L-1,2-propanediol oxidoreductase 3361656 fucO 7151259 fucO Escherichia coli IAI39 L-1,2-propanediol oxidoreductase YP_002409145.1 3360505 R 585057 CDS YP_002409146.1 218701517 7151449 complement(3361681..3362328) 1 NC_011750.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 3362328 fucA 7151449 fucA Escherichia coli IAI39 L-fuculose phosphate aldolase YP_002409146.1 3361681 R 585057 CDS YP_002409147.1 218701518 7151446 3362875..3364191 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 90036697, 2553671, 2664711, 7783647; Product type t : transporter; L-fucose transporter 3364191 fucP 7151446 fucP Escherichia coli IAI39 L-fucose transporter YP_002409147.1 3362875 D 585057 CDS YP_002409148.1 218701519 7151450 3364224..3365999 1 NC_011750.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 3365999 fucI 7151450 fucI Escherichia coli IAI39 L-fucose isomerase YP_002409148.1 3364224 D 585057 CDS YP_002409149.1 218701520 7151447 3366078..3367526 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 90036697, 2664711, 13905785; Product type e : enzyme; L-fuculokinase 3367526 fucK 7151447 fucK Escherichia coli IAI39 L-fuculokinase YP_002409149.1 3366078 D 585057 CDS YP_002409150.1 218701521 7151448 3367528..3367950 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15060078, 12738765, 80049526, 2664711; Product type e : enzyme; L-fucose mutarotase 3367950 fucU 7151448 fucU Escherichia coli IAI39 L-fucose mutarotase YP_002409150.1 3367528 D 585057 CDS YP_002409151.1 218701522 7151452 3368008..3368739 1 NC_011750.1 regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 3368739 fucR 7151452 fucR Escherichia coli IAI39 DNA-binding transcriptional activator FucR YP_002409151.1 3368008 D 585057 CDS YP_002409152.1 218701523 7151451 complement(3368783..3369883) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 21188420, 7704273; Product type pe : putative enzyme; putative RNA 2'-O-ribose methyltransferase 3369883 ygdE 7151451 ygdE Escherichia coli IAI39 putative RNA 2'-O-ribose methyltransferase YP_002409152.1 3368783 R 585057 CDS YP_002409153.1 218701524 7153945 complement(3369876..3370271) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7704273; Product type pm : putative membrane component; hypothetical protein 3370271 ygdD 7153945 ygdD Escherichia coli IAI39 hypothetical protein YP_002409153.1 3369876 R 585057 CDS YP_002409154.1 218701525 7153944 complement(3370290..3371207) 1 NC_011750.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA 3371207 gcvA 7153944 gcvA Escherichia coli IAI39 DNA-binding transcriptional activator GcvA YP_002409154.1 3370290 R 585057 CDS YP_002409155.1 218701526 7151496 complement(3371558..3371785) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3371785 ygdI 7151496 ygdI Escherichia coli IAI39 hypothetical protein YP_002409155.1 3371558 R 585057 CDS YP_002409156.1 218701527 7153947 3371977..3373182 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15148362, 9278392, 10739946, 10829016; Product type e : enzyme; cysteine sulfinate desulfinase 3373182 csdA 7153947 csdA Escherichia coli IAI39 cysteine sulfinate desulfinase YP_002409156.1 3371977 D 585057 CDS YP_002409157.1 218701528 7151002 3373182..3373625 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative Fe-S metabolism protein (sufE-like) 3373625 ygdK 7151002 ygdK Escherichia coli IAI39 putative Fe-S metabolism protein (sufE-like) YP_002409157.1 3373182 D 585057 CDS YP_002409158.1 218701529 7153948 complement(3373676..3374482) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3374482 ygdL 7153948 ygdL Escherichia coli IAI39 hypothetical protein YP_002409158.1 3373676 R 585057 CDS YP_002409159.1 218701530 7153949 complement(3374721..3375818) 1 NC_011750.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A 3375818 mltA 7153949 mltA Escherichia coli IAI39 murein transglycosylase A YP_002409159.1 3374721 R 585057 CDS YP_002409160.1 218701531 7150569 complement(3376289..3377542) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12787347, 21348478; Product type e : enzyme; N-acetylmuramoyl-L-alanine amidase 3377542 amiC 7150569 amiC Escherichia coli IAI39 N-acetylmuramoyl-L-alanine amidase YP_002409160.1 3376289 R 585057 CDS YP_002409161.1 218701532 7150727 3377774..3379105 1 NC_011750.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 3379105 argA 7150727 argA Escherichia coli IAI39 N-acetylglutamate synthase YP_002409161.1 3377774 D 585057 CDS YP_002409162.1 218701533 7150760 complement(3379167..3380993) 1 NC_011750.1 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha 3380993 recD 7150760 recD Escherichia coli IAI39 exonuclease V subunit alpha YP_002409162.1 3379167 R 585057 CDS YP_002409163.1 218701534 7152590 complement(3380993..3384535) 1 NC_011750.1 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta 3384535 recB 7152590 recB Escherichia coli IAI39 exonuclease V subunit beta YP_002409163.1 3380993 R 585057 CDS YP_002409164.1 218701535 7152588 complement(3384528..3387416) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91193232, 1570301, 3308636, 3534791, 3537960, 8099278; Product type e : enzyme; protease III 3387416 ptr 7152588 ptr Escherichia coli IAI39 protease III YP_002409164.1 3384528 R 585057 CDS YP_002409165.1 218701536 7152515 complement(3387592..3390960) 1 NC_011750.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma 3390960 recC 7152515 recC Escherichia coli IAI39 exonuclease V subunit gamma YP_002409165.1 3387592 R 585057 CDS YP_002409166.1 218701537 7152589 complement(3390973..3391296) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein 3391296 ppdC 7152589 ppdC Escherichia coli IAI39 hypothetical protein YP_002409166.1 3390973 R 585057 CDS YP_002409167.1 218701538 7152456 complement(3391281..3391688) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3391688 ygdB 7152456 ygdB Escherichia coli IAI39 hypothetical protein YP_002409167.1 3391281 R 585057 CDS YP_002409168.1 218701539 7153943 complement(3391685..3392248) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein 3392248 ppdB 7153943 ppdB Escherichia coli IAI39 hypothetical protein YP_002409168.1 3391685 R 585057 CDS YP_002409169.1 218701540 7152455 complement(3392239..3392709) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein 3392709 ppdA 7152455 ppdA Escherichia coli IAI39 hypothetical protein YP_002409169.1 3392239 R 585057 CDS YP_002409170.1 218701541 7152454 complement(3392894..3393688) 1 NC_011750.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 3393688 thyA 7152454 thyA Escherichia coli IAI39 thymidylate synthase YP_002409170.1 3392894 R 585057 CDS YP_002409171.1 218701542 7152982 complement(3393695..3394570) 1 NC_011750.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 3394570 lgt 7152982 lgt Escherichia coli IAI39 prolipoprotein diacylglyceryl transferase YP_002409171.1 3393695 R 585057 CDS YP_002409172.1 218701543 7151933 complement(3394721..3396967) 1 NC_011750.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain 3396967 ptsP 7151933 ptsP Escherichia coli IAI39 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain YP_002409172.1 3394721 R 585057 CDS YP_002409173.1 218701544 7152522 complement(3396980..3397510) 1 NC_011750.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 3397510 nudH 7152522 nudH Escherichia coli IAI39 dinucleoside polyphosphate hydrolase YP_002409173.1 3396980 R 585057 CDS YP_002409174.1 218701545 7152268 3397955..3398116 1 NC_011750.1 hypothetical protein 3398116 7152268 ECIAI39_3250 Escherichia coli IAI39 hypothetical protein YP_002409174.1 3397955 D 585057 CDS YP_002409175.1 218701546 7150141 3398195..3398884 1 NC_011750.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 3398884 mutH 7150141 mutH Escherichia coli IAI39 DNA mismatch repair protein YP_002409175.1 3398195 D 585057 CDS YP_002409176.1 218701547 7152155 3398953..3399666 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3399666 ygdQ 7152155 ygdQ Escherichia coli IAI39 hypothetical protein YP_002409176.1 3398953 D 585057 CDS YP_002409177.1 218701548 7153950 3399804..3400022 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3400022 ygdR 7153950 ygdR Escherichia coli IAI39 hypothetical protein YP_002409177.1 3399804 D 585057 CDS YP_002409178.1 218701549 7153951 3400130..3401170 1 NC_011750.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; putative aldo-keto reductase 3401170 tas 7153951 tas Escherichia coli IAI39 putative aldo-keto reductase YP_002409178.1 3400130 D 585057 CDS YP_002409179.1 218701550 7152942 complement(3401202..3402395) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8300626; Product type pm : putative membrane component; lysophospholipid transporter LplT 3402395 ygeD 7152942 ygeD Escherichia coli IAI39 lysophospholipid transporter LplT YP_002409179.1 3401202 R 585057 CDS YP_002409180.1 218701551 7153953 complement(3402388..3404547) 1 NC_011750.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase 3404547 aas 7153953 aas Escherichia coli IAI39 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase YP_002409180.1 3402388 R 585057 CDS YP_002409181.1 218701552 7152301 3405133..3406164 1 NC_011750.1 controls transcription of galETKM; DNA-binding transcriptional regulator GalR 3406164 galR 7152301 galR Escherichia coli IAI39 DNA-binding transcriptional regulator GalR YP_002409181.1 3405133 D 585057 CDS YP_002409182.1 218701553 7151475 complement(3406171..3407433) 1 NC_011750.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase 3407433 lysA 7151475 lysA Escherichia coli IAI39 diaminopimelate decarboxylase YP_002409182.1 3406171 R 585057 CDS YP_002409183.1 218701554 7151982 3407555..3408490 1 NC_011750.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; DNA-binding transcriptional regulator LysR 3408490 lysR 7151982 lysR Escherichia coli IAI39 DNA-binding transcriptional regulator LysR YP_002409183.1 3407555 D 585057 CDS YP_002409184.1 218701555 7151985 complement(3408477..3409169) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15135544; Product type pe : putative enzyme; putative racemase 3409169 ygeA 7151985 ygeA Escherichia coli IAI39 putative racemase YP_002409184.1 3408477 R 585057 CDS YP_002409185.1 218701556 7153952 complement(3409298..3410716) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7030324, 90239116, 91154204, 2836407, 3543693, 6319708; Product type t : transporter; arabinose transporter 3410716 araE 7153952 araE Escherichia coli IAI39 arabinose transporter YP_002409185.1 3409298 R 585057 CDS YP_002409186.1 218701557 7150751 complement(3411031..3411792) 1 NC_011750.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase 3411792 kduD 7150751 kduD Escherichia coli IAI39 2-deoxy-D-gluconate 3-dehydrogenase YP_002409186.1 3411031 R 585057 CDS YP_002409187.1 218701558 7151890 complement(3411822..3412658) 1 NC_011750.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase 3412658 kduI 7151890 kduI Escherichia coli IAI39 5-keto-4-deoxyuronate isomerase YP_002409187.1 3411822 R 585057 CDS YP_002409188.1 218701559 7151891 complement(3412945..3414126) 1 NC_011750.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 3414126 yqeF 7151891 yqeF Escherichia coli IAI39 acetyl-CoA acetyltransferase YP_002409188.1 3412945 R 585057 CDS YP_002409189.1 218701560 7154506 3414381..3415610 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3415610 yqeG 7154506 yqeG Escherichia coli IAI39 putative transporter YP_002409189.1 3414381 D 585057 CDS YP_002409190.1 218701561 7154507 3416070..3416702 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3416702 yqeH 7154507 yqeH Escherichia coli IAI39 hypothetical protein YP_002409190.1 3416070 D 585057 CDS YP_002409191.1 218701562 7154508 3417036..3417845 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3417845 yqeI 7154508 yqeI Escherichia coli IAI39 putative transcriptional regulator YP_002409191.1 3417036 D 585057 CDS YP_002409192.1 218701563 7154509 3417838..3418320 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3418320 yqeJ 7154509 yqeJ Escherichia coli IAI39 hypothetical protein YP_002409192.1 3417838 D 585057 CDS YP_002409193.1 218701564 7154511 complement(3419033..3419269) 1 NC_011750.1 hypothetical protein 3419269 7154511 ECIAI39_3270 Escherichia coli IAI39 hypothetical protein YP_002409193.1 3419033 R 585057 CDS YP_002409194.1 218701565 7150142 3419323..3419760 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3419760 ygeF 7150142 ygeF Escherichia coli IAI39 hypothetical protein YP_002409194.1 3419323 D 585057 CDS YP_002409195.1 218701566 7153954 3420045..3420536 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative chaperone 3420536 ygeG 7153954 ygeG Escherichia coli IAI39 putative chaperone YP_002409195.1 3420045 D 585057 CDS YP_002409196.1 218701567 7153955 3420871..3422247 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15150243; Product type pr : putative regulator; transcriptional regulator 3422247 ygeH 7153955 ygeH Escherichia coli IAI39 transcriptional regulator YP_002409196.1 3420871 D 585057 CDS YP_002409197.1 218701568 7153956 3422373..3422633 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3422633 ygeI 7153956 ygeI Escherichia coli IAI39 hypothetical protein YP_002409197.1 3422373 D 585057 CDS YP_002409198.1 218701569 7153957 3422717..3423220 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidoglycan-binding-like protein 3423220 7153957 ECIAI39_3275 Escherichia coli IAI39 putative peptidoglycan-binding-like protein YP_002409198.1 3422717 D 585057 CDS YP_002409199.1 218701570 7150143 complement(3423343..3423846) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 3423846 insB 7150143 insB Escherichia coli IAI39 IS1 transposase InsAB' YP_002409199.1 3423343 R 585057 CDS YP_002409200.1 218701571 7151797 complement(3423765..3424040) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 3424040 insA 7151797 insA Escherichia coli IAI39 IS1 repressor protein InsA YP_002409200.1 3423765 R 585057 CDS YP_002409201.1 218701572 7151786 complement(3424183..3424362) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3424362 7151786 ECIAI39_3278 Escherichia coli IAI39 hypothetical protein YP_002409201.1 3424183 R 585057 CDS YP_002409202.1 218701573 7150144 complement(3424429..3426081) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3426081 7150144 ECIAI39_3279 Escherichia coli IAI39 hypothetical protein YP_002409202.1 3424429 R 585057 CDS YP_002409203.1 218701574 7150596 complement(3426424..3427200) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15150243; Product type r : regulator; Tetratricopeptide repeat transcriptional regulator 3427200 ygeR 7150596 ygeR Escherichia coli IAI39 Tetratricopeptide repeat transcriptional regulator YP_002409203.1 3426424 R 585057 CDS YP_002409204.1 218701575 7153958 3427631..3429889 1 NC_011750.1 putative molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 3429889 xdhA 7153958 xdhA Escherichia coli IAI39 xanthine dehydrogenase subunit XdhA YP_002409204.1 3427631 D 585057 CDS YP_002409205.1 218701576 7153175 3429900..3430778 1 NC_011750.1 FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 3430778 xdhB 7153175 xdhB Escherichia coli IAI39 xanthine dehydrogenase subunit XdhB YP_002409205.1 3429900 D 585057 CDS YP_002409206.1 218701577 7153176 3430775..3431254 1 NC_011750.1 iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 3431254 xdhC 7153176 xdhC Escherichia coli IAI39 xanthine dehydrogenase subunit XdhC YP_002409206.1 3430775 D 585057 CDS YP_002409207.1 218701578 7153177 complement(3431294..3433072) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3433072 ygeV 7153177 ygeV Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002409207.1 3431294 R 585057 CDS YP_002409208.1 218701579 7153959 3433548..3434738 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; aspartate/ornithine carbamoyltransferase family protein 3434738 ygeW 7153959 ygeW Escherichia coli IAI39 aspartate/ornithine carbamoyltransferase family protein YP_002409208.1 3433548 D 585057 CDS YP_002409209.1 218701580 7153960 3434796..3435992 1 NC_011750.1 catalyzes the formation of pyruvate from 2,3-diaminopropionate; diaminopropionate ammonia-lyase 3435992 ygeX 7153960 ygeX Escherichia coli IAI39 diaminopropionate ammonia-lyase YP_002409209.1 3434796 D 585057 CDS YP_002409210.1 218701581 7153961 3436050..3437261 1 NC_011750.1 Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases; peptidase 3437261 ygeY 7153961 ygeY Escherichia coli IAI39 peptidase YP_002409210.1 3436050 D 585057 CDS YP_002409211.1 218701582 7153962 3437314..3438699 1 NC_011750.1 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; phenylhydantoinase 3438699 hyuA 7153962 hyuA Escherichia coli IAI39 phenylhydantoinase YP_002409211.1 3437314 D 585057 CDS YP_002409212.1 218701583 7151739 3438747..3439679 1 NC_011750.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 3439679 yqeA 7151739 yqeA Escherichia coli IAI39 carbamate kinase YP_002409212.1 3438747 D 585057 CDS YP_002409213.1 218701584 7154503 complement(3439720..3441345) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3441345 yqeB 7154503 yqeB Escherichia coli IAI39 hypothetical protein YP_002409213.1 3439720 R 585057 CDS YP_002409214.1 218701585 7154504 complement(3441393..3442163) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3442163 yqeC 7154504 yqeC Escherichia coli IAI39 hypothetical protein YP_002409214.1 3441393 R 585057 CDS YP_002409215.1 218701586 7154505 3442266..3442844 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3442844 ygfJ 7154505 ygfJ Escherichia coli IAI39 hypothetical protein YP_002409215.1 3442266 D 585057 CDS YP_002409216.1 218701587 7153968 3443166..3446264 1 NC_011750.1 with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase; putative selenate reductase subunit YgfK 3446264 ygfK 7153968 ygfK Escherichia coli IAI39 putative selenate reductase subunit YgfK YP_002409216.1 3443166 D 585057 CDS YP_002409217.1 218701588 7153969 3446267..3447595 1 NC_011750.1 in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS; putative chlorohydrolase/aminohydrolase 3447595 ssnA 7153969 ssnA Escherichia coli IAI39 putative chlorohydrolase/aminohydrolase YP_002409217.1 3446267 D 585057 CDS YP_002409218.1 218701589 7152905 3447646..3448425 1 NC_011750.1 with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain; putative selenate reductase subunit YgfM 3448425 ygfM 7152905 ygfM Escherichia coli IAI39 putative selenate reductase subunit YgfM YP_002409218.1 3447646 D 585057 CDS YP_002409219.1 218701590 7153970 3448422..3451292 1 NC_011750.1 with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration; putative selenate reductase subunit YgfN 3451292 xdhD 7153970 xdhD Escherichia coli IAI39 putative selenate reductase subunit YgfN YP_002409219.1 3448422 D 585057 CDS YP_002409220.1 218701591 7153178 3451457..3452857 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20372655, 98213740; Product type pt : putative transporter; putative transporter 3452857 ygfO 7153178 ygfO Escherichia coli IAI39 putative transporter YP_002409220.1 3451457 D 585057 CDS YP_002409221.1 218701592 7153971 3452872..3454191 1 NC_011750.1 Catalyzes the deamination of guanine; guanine deaminase 3454191 guaD 7153971 guaD Escherichia coli IAI39 guanine deaminase YP_002409221.1 3452872 D 585057 CDS YP_002409222.1 218701593 7151599 3454227..3455594 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3455594 ygfQ 7151599 ygfQ Escherichia coli IAI39 putative transporter YP_002409222.1 3454227 D 585057 CDS YP_002409223.1 218701594 7153972 complement(3455630..3456118) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative oxidoreductase 3456118 ygfS 7153972 ygfS Escherichia coli IAI39 putative oxidoreductase YP_002409223.1 3455630 R 585057 CDS YP_002409224.1 218701595 7153973 complement(3456118..3458037) 1 NC_011750.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); putative oxidoreductase 3458037 ygfT 7153973 ygfT Escherichia coli IAI39 putative oxidoreductase YP_002409224.1 3456118 R 585057 CDS YP_002409225.1 218701596 7153974 3458340..3458528 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 3458528 7153974 ECIAI39_3302 Escherichia coli IAI39 hypothetical protein YP_002409225.1 3458340 D 585057 CDS YP_002409226.1 218701597 7150146 3458473..3459921 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9098051; Product type t : transporter; transporter 3459921 ygfU 7150146 ygfU Escherichia coli IAI39 transporter YP_002409226.1 3458473 D 585057 CDS YP_002409227.1 218701598 7153975 3460170..3460718 1 NC_011750.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 3460718 idi 7153975 idi Escherichia coli IAI39 isopentenyl-diphosphate delta-isomerase YP_002409227.1 3460170 D 585057 CDS YP_002409228.1 218701599 7151753 complement(3460761..3462278) 1 NC_011750.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 3462278 lysS 7151753 lysS Escherichia coli IAI39 lysyl-tRNA synthetase YP_002409228.1 3460761 R 585057 CDS YP_002409229.1 218701600 7151986 complement(join(3462288..3463310,3463312..3463386)) 1 NC_011750.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 3463386 prfB 7151986 prfB Escherichia coli IAI39 peptide chain release factor 2 YP_002409229.1 3462288 R 585057 CDS YP_002409230.1 218701601 7152473 complement(3463477..3465210) 1 NC_011750.1 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ 3465210 recJ 7152473 recJ Escherichia coli IAI39 ssDNA exonuclease RecJ YP_002409230.1 3463477 R 585057 CDS YP_002409231.1 218701602 7152593 complement(3465216..3465926) 1 NC_011750.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC 3465926 dsbC 7152593 dsbC Escherichia coli IAI39 thiol:disulfide interchange protein DsbC YP_002409231.1 3465216 R 585057 CDS YP_002409232.1 218701603 7151174 complement(3465951..3466847) 1 NC_011750.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 3466847 xerD 7151174 xerD Escherichia coli IAI39 site-specific tyrosine recombinase XerD YP_002409232.1 3465951 R 585057 CDS YP_002409233.1 218701604 7153180 3466959..3467480 1 NC_011750.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 3467480 fldB 7153180 fldB Escherichia coli IAI39 flavodoxin FldB YP_002409233.1 3466959 D 585057 CDS YP_002409234.1 218701605 7151348 complement(3467520..3467927) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3467927 ygfX 7151348 ygfX Escherichia coli IAI39 hypothetical protein YP_002409234.1 3467520 R 585057 CDS YP_002409235.1 218701606 7153976 complement(3467908..3468174) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3468174 ygfY 7153976 ygfY Escherichia coli IAI39 hypothetical protein YP_002409235.1 3467908 R 585057 CDS YP_002409236.1 218701607 7153977 3468417..3469397 1 NC_011750.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; putative global regulator 3469397 ygfZ 7153977 ygfZ Escherichia coli IAI39 putative global regulator YP_002409236.1 3468417 D 585057 CDS YP_002409237.1 218701608 7153978 complement(3469474..3470133) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative hemolysin, inner membrane subunit 3470133 yqfA 7153978 yqfA Escherichia coli IAI39 putative hemolysin, inner membrane subunit YP_002409237.1 3469474 R 585057 CDS YP_002409238.1 218701609 7154512 complement(3470297..3470608) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3470608 yqfB 7154512 yqfB Escherichia coli IAI39 hypothetical protein YP_002409238.1 3470297 R 585057 CDS YP_002409239.1 218701610 7154513 3470647..3472086 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 88297127, 92334140; Product type e : enzyme; 6-phospho-beta-glucosidase A 3472086 bglA 7154513 bglA Escherichia coli IAI39 6-phospho-beta-glucosidase A YP_002409239.1 3470647 D 585057 CDS YP_002409240.1 218701611 7150859 complement(3472252..3475125) 1 NC_011750.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 3475125 gcvP 7150859 gcvP Escherichia coli IAI39 glycine dehydrogenase YP_002409240.1 3472252 R 585057 CDS YP_002409241.1 218701612 7151498 complement(3475243..3475632) 1 NC_011750.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 3475632 gcvH 7151498 gcvH Escherichia coli IAI39 glycine cleavage system protein H YP_002409241.1 3475243 R 585057 CDS YP_002409242.1 218701613 7151497 complement(3475656..3476750) 1 NC_011750.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 3476750 gcvT 7151497 gcvT Escherichia coli IAI39 glycine cleavage system aminomethyltransferase T YP_002409242.1 3475656 R 585057 CDS YP_002409243.1 218701614 7151500 complement(3477198..3478400) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1339425; Product type pe : putative enzyme; hypothetical protein 3478400 visC 7151500 visC Escherichia coli IAI39 hypothetical protein YP_002409243.1 3477198 R 585057 CDS YP_002409244.1 218701615 7153130 complement(3478423..3479601) 1 NC_011750.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase 3479601 ubiH 7153130 ubiH Escherichia coli IAI39 2-octaprenyl-6-methoxyphenyl hydroxylase YP_002409244.1 3478423 R 585057 CDS YP_002409245.1 218701616 7153075 complement(3479598..3480923) 1 NC_011750.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II 3480923 pepP 7153075 pepP Escherichia coli IAI39 proline aminopeptidase P II YP_002409245.1 3479598 R 585057 CDS YP_002409246.1 218701617 7152366 complement(3480949..3481527) 1 NC_011750.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein 3481527 ygfB 7152366 ygfB Escherichia coli IAI39 hypothetical protein YP_002409246.1 3480949 R 585057 CDS YP_002409247.1 218701618 7153964 3481695..3482024 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 412171; Product type cp : cell process; Z-ring-associated protein 3482024 zapA 7153964 zapA Escherichia coli IAI39 Z-ring-associated protein YP_002409247.1 3481695 D 585057 CDS YP_002409248.1 218701619 7152909 3482324..3482872 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14727089, 2579060; Product type pe : putative enzyme; putative ligase 3482872 ygfA 7152909 ygfA Escherichia coli IAI39 putative ligase YP_002409248.1 3482324 D 585057 CDS YP_002409249.1 218701620 7152789 complement(3483261..3484493) 1 NC_011750.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 3484493 serA 7152789 serA Escherichia coli IAI39 D-3-phosphoglycerate dehydrogenase YP_002409249.1 3483261 R 585057 CDS YP_002409250.1 218701621 7152830 complement(3484749..3485408) 1 NC_011750.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 3485408 rpiA 7152830 rpiA Escherichia coli IAI39 ribose-5-phosphate isomerase A YP_002409250.1 3484749 R 585057 CDS YP_002409251.1 218701622 7152668 3485791..3486684 1 NC_011750.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 3486684 argP 7152668 argP Escherichia coli IAI39 chromosome replication initiation inhibitor protein YP_002409251.1 3485791 D 585057 CDS YP_002409252.1 218701623 7150770 3486888..3489032 1 NC_011750.1 MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 3489032 yliK 7150770 yliK Escherichia coli IAI39 methylmalonyl-CoA mutase YP_002409252.1 3486888 D 585057 CDS YP_002409253.1 218701624 7154379 3489025..3490020 1 NC_011750.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 3490020 argK 7154379 argK Escherichia coli IAI39 arginine/ornithine transport system ATPase YP_002409253.1 3489025 D 585057 CDS YP_002409254.1 218701625 7150768 3490031..3490816 1 NC_011750.1 catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA; methylmalonyl-CoA decarboxylase 3490816 ygfG 7150768 ygfG Escherichia coli IAI39 methylmalonyl-CoA decarboxylase YP_002409254.1 3490031 D 585057 CDS YP_002409255.1 218701626 7153965 3490840..3492318 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20233703; Product type e : enzyme; propionyl-CoA:succinate-CoA transferase 3492318 ygfH 7153965 ygfH Escherichia coli IAI39 propionyl-CoA:succinate-CoA transferase YP_002409255.1 3490840 D 585057 CDS YP_002409256.1 218701627 7153966 complement(3492315..3493211) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3493211 ygfI 7153966 ygfI Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002409256.1 3492315 R 585057 CDS YP_002409257.1 218701628 7153967 complement(3493379..3494119) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3494119 yggE 7153967 yggE Escherichia coli IAI39 hypothetical protein YP_002409257.1 3493379 R 585057 CDS YP_002409258.1 218701629 7153981 complement(3494212..3494847) 1 NC_011750.1 Involved in the export of arginine; arginine exporter protein 3494847 argO 7153981 argO Escherichia coli IAI39 arginine exporter protein YP_002409258.1 3494212 R 585057 CDS YP_002409259.1 218701630 7150769 complement(3494986..3495846) 1 NC_011750.1 participates in the regulation of osmotic pressure changes within the cel; mechanosensitive channel MscS 3495846 mscS 7150769 mscS Escherichia coli IAI39 mechanosensitive channel MscS YP_002409259.1 3494986 R 585057 CDS YP_002409260.1 218701631 7152133 complement(3496037..3497116) 1 NC_011750.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 3497116 fbaA 7152133 fbaA Escherichia coli IAI39 fructose-bisphosphate aldolase YP_002409260.1 3496037 R 585057 CDS YP_002409261.1 218701632 7151279 complement(3497331..3498494) 1 NC_011750.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 3498494 pgk 7151279 pgk Escherichia coli IAI39 phosphoglycerate kinase YP_002409261.1 3497331 R 585057 CDS YP_002409262.1 218701633 7152382 complement(3498544..3499563) 1 NC_011750.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase 3499563 epd 7152382 epd Escherichia coli IAI39 erythrose 4-phosphate dehydrogenase YP_002409262.1 3498544 R 585057 CDS YP_002409263.1 218701634 7151232 3499935..3500366 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3500366 7151232 ECIAI39_3342 Escherichia coli IAI39 hypothetical protein YP_002409263.1 3499935 D 585057 CDS YP_002409264.1 218701635 7150147 3500290..3500967 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC-type transport system 3500967 7150147 ECIAI39_3343 Escherichia coli IAI39 putative ABC-type transport system YP_002409264.1 3500290 D 585057 CDS YP_002409265.1 218701636 7150148 3500968..3501675 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC-type transport system 3501675 7150148 ECIAI39_3344 Escherichia coli IAI39 putative ABC-type transport system YP_002409265.1 3500968 D 585057 CDS YP_002409266.1 218701637 7150149 3501657..3502340 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ATP-binding protein of ABC transport system 3502340 7150149 ECIAI39_3345 Escherichia coli IAI39 putative ATP-binding protein of ABC transport system YP_002409266.1 3501657 D 585057 CDS YP_002409267.1 218701638 7150150 3502301..3503011 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ATP-binding protein of ABC transport system 3503011 7150150 ECIAI39_3346 Escherichia coli IAI39 putative ATP-binding protein of ABC transport system YP_002409267.1 3502301 D 585057 CDS YP_002409268.1 218701639 7150151 complement(3502983..3503696) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative fructose transport system kinase 3503696 frcK 7150151 frcK Escherichia coli IAI39 putative fructose transport system kinase YP_002409268.1 3502983 R 585057 CDS YP_002409269.1 218701640 7153979 complement(3503693..3504202) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3504202 yggD 7153979 yggD Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002409269.1 3503693 R 585057 CDS YP_002409270.1 218701641 7153980 complement(3504224..3505189) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; fructose-1,6-bisphosphatase II-like protein 3505189 yggF 7153980 yggF Escherichia coli IAI39 fructose-1,6-bisphosphatase II-like protein YP_002409270.1 3504224 R 585057 CDS YP_002409271.1 218701642 7153982 complement(3505186..3506463) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dehydrogenase 3506463 yggP 7153982 yggP Escherichia coli IAI39 putative dehydrogenase YP_002409271.1 3505186 R 585057 CDS YP_002409272.1 218701643 7153989 complement(3506478..3507866) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8353127; Product type t : transporter; PTS system mannitol-specific transporter subunit IIBC 3507866 cmtA 7153989 cmtA Escherichia coli IAI39 PTS system mannitol-specific transporter subunit IIBC YP_002409272.1 3506478 R 585057 CDS YP_002409273.1 218701644 7150971 complement(3507894..3508337) 1 NC_011750.1 TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein; putative mannitol phosphotransferase subunit EIIA 3508337 cmtB 7150971 cmtB Escherichia coli IAI39 putative mannitol phosphotransferase subunit EIIA YP_002409273.1 3507894 R 585057 CDS YP_002409274.1 218701645 7150972 3508678..3509622 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane protease 3509622 7150972 ECIAI39_3353 Escherichia coli IAI39 putative membrane protease YP_002409274.1 3508678 D 585057 CDS YP_002409275.1 218701646 7150152 complement(3509668..3511659) 1 NC_011750.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 3511659 tktA 7150152 tktA Escherichia coli IAI39 transketolase YP_002409275.1 3509668 R 585057 CDS YP_002409276.1 218701647 7152989 3511937..3512695 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1310091; Product type pe : putative enzyme; putative peptidase 3512695 yggG 7152989 yggG Escherichia coli IAI39 putative peptidase YP_002409276.1 3511937 D 585057 CDS YP_002409277.1 218701648 7153983 complement(3512743..3513663) 1 NC_011750.1 catalyzes the formation of putrescine from agmatine; agmatinase 3513663 speB 7153983 speB Escherichia coli IAI39 agmatinase YP_002409277.1 3512743 R 585057 CDS YP_002409278.1 218701649 7152880 complement(3513799..3514530) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3514530 7152880 ECIAI39_3357 Escherichia coli IAI39 hypothetical protein YP_002409278.1 3513799 R 585057 CDS YP_002409279.1 218701650 7150153 complement(3514676..3516652) 1 NC_011750.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase 3516652 speA 7150153 speA Escherichia coli IAI39 arginine decarboxylase YP_002409279.1 3514676 R 585057 CDS YP_002409280.1 218701651 7152879 complement(3516661..3516807) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3516807 yqgB 7152879 yqgB Escherichia coli IAI39 hypothetical protein YP_002409280.1 3516661 R 585057 CDS YP_002409281.1 218701652 7154515 3517447..3518601 1 NC_011750.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3518601 metK 7154515 metK Escherichia coli IAI39 S-adenosylmethionine synthetase YP_002409281.1 3517447 D 585057 CDS YP_002409282.1 218701653 7152059 3519037..3520431 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9182541; Product type t : transporter; D-galactose transporter 3520431 galP 7152059 galP Escherichia coli IAI39 D-galactose transporter YP_002409282.1 3519037 D 585057 CDS YP_002409283.1 218701654 7151474 3520508..3521005 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7984428, 8113204; hypothetical protein 3521005 sprT 7151474 sprT Escherichia coli IAI39 hypothetical protein YP_002409283.1 3520508 D 585057 CDS YP_002409284.1 218701655 7152890 3521100..3521807 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 72060411, 92335461, 4955462, 7867949, 8113204; Product type e : enzyme; DNA-specific endonuclease I 3521807 endA 7152890 endA Escherichia coli IAI39 DNA-specific endonuclease I YP_002409284.1 3521100 D 585057 CDS YP_002409285.1 218701656 7151220 3521887..3522618 1 NC_011750.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3522618 yggJ 7151220 yggJ Escherichia coli IAI39 16S ribosomal RNA methyltransferase RsmE YP_002409285.1 3521887 D 585057 CDS YP_002409286.1 218701657 7153985 3522631..3523581 1 NC_011750.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3523581 gshB 7153985 gshB Escherichia coli IAI39 glutathione synthetase YP_002409286.1 3522631 D 585057 CDS YP_002409287.1 218701658 7151592 3523690..3524253 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3524253 yqgE 7151592 yqgE Escherichia coli IAI39 hypothetical protein YP_002409287.1 3523690 D 585057 CDS YP_002409288.1 218701659 7154516 3524253..3524669 1 NC_011750.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3524669 yqgF 7154516 yqgF Escherichia coli IAI39 Holliday junction resolvase-like protein YP_002409288.1 3524253 D 585057 CDS YP_002409289.1 218701660 7154517 complement(3524844..3525824) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1676385; Product type t : transporter; transporter 3525824 yggR 7154517 yggR Escherichia coli IAI39 transporter YP_002409289.1 3524844 R 585057 CDS YP_002409290.1 218701661 7153990 3525842..3526546 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3526546 yggS 7153990 yggS Escherichia coli IAI39 hypothetical protein YP_002409290.1 3525842 D 585057 CDS YP_002409291.1 218701662 7153991 3526564..3527130 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3527130 yggT 7153991 yggT Escherichia coli IAI39 hypothetical protein YP_002409291.1 3526564 D 585057 CDS YP_002409292.1 218701663 7153992 3527127..3527417 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12975589; hypothetical protein 3527417 yggU 7153992 yggU Escherichia coli IAI39 hypothetical protein YP_002409292.1 3527127 D 585057 CDS YP_002409293.1 218701664 7153993 3527425..3528018 1 NC_011750.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 3528018 yggV 7153993 yggV Escherichia coli IAI39 putative deoxyribonucleotide triphosphate pyrophosphatase YP_002409293.1 3527425 D 585057 CDS YP_002409294.1 218701665 7153994 3528011..3529147 1 NC_011750.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3529147 yggW 7153994 yggW Escherichia coli IAI39 coproporphyrinogen III oxidase YP_002409294.1 3528011 D 585057 CDS YP_002409295.1 218701666 7153995 3529460..3530446 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative c4-dicarboxylate transport system binding protein 3530446 7153995 ECIAI39_3374 Escherichia coli IAI39 putative c4-dicarboxylate transport system binding protein YP_002409295.1 3529460 D 585057 CDS YP_002409296.1 218701667 7150154 3530482..3530994 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative TRAP-type C4-dicarboxylate transport system, small permease component 3530994 7150154 ECIAI39_3375 Escherichia coli IAI39 putative TRAP-type C4-dicarboxylate transport system, small permease component YP_002409296.1 3530482 D 585057 CDS YP_002409297.1 218701668 7150156 3531641..3531967 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 3531967 7150156 ECIAI39_3377 Escherichia coli IAI39 transposase ORF A, IS629 YP_002409297.1 3531641 D 585057 CDS YP_002409298.1 218701669 7150157 3531964..3532854 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 3532854 7150157 ECIAI39_3378 Escherichia coli IAI39 transposase ORF B, IS629 YP_002409298.1 3531964 D 585057 CDS YP_002409299.1 218701670 7154017 complement(3533664..3534671) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3534671 yggM 7154017 yggM Escherichia coli IAI39 hypothetical protein YP_002409299.1 3533664 R 585057 CDS YP_002409300.1 218701671 7153987 complement(3534788..3535834) 1 NC_011750.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II 3535834 ansB 7153987 ansB Escherichia coli IAI39 L-asparaginase II YP_002409300.1 3534788 R 585057 CDS YP_002409301.1 218701672 7150738 complement(3536010..3536729) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3536729 yggN 7150738 yggN Escherichia coli IAI39 hypothetical protein YP_002409301.1 3536010 R 585057 CDS YP_002409302.1 218701673 7153988 complement(3536913..3537239) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3537239 yggL 7153988 yggL Escherichia coli IAI39 hypothetical protein YP_002409302.1 3536913 R 585057 CDS YP_002409303.1 218701674 7153986 complement(3537239..3537958) 1 NC_011750.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 3537958 trmB 7153986 trmB Escherichia coli IAI39 tRNA (guanine-N(7)-)-methyltransferase YP_002409303.1 3537239 R 585057 CDS YP_002409304.1 218701675 7153984 3538119..3539171 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14730969, 20187555, 20316830, 20580749, 21438845, 90046892, 92409600, 9801309, 2001994, 2197596, 9846876; Product type e : enzyme; adenine DNA glycosylase 3539171 mutY 7153984 mutY Escherichia coli IAI39 adenine DNA glycosylase YP_002409304.1 3538119 D 585057 CDS YP_002409305.1 218701676 7152160 3539199..3539474 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594836, 10493123, 9298646, 9868784; Product type f : factor; hypothetical protein 3539474 yggX 7152160 yggX Escherichia coli IAI39 hypothetical protein YP_002409305.1 3539199 D 585057 CDS YP_002409306.1 218701677 7153996 3539539..3540618 1 NC_011750.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3540618 mltC 7153996 mltC Escherichia coli IAI39 murein transglycosylase C YP_002409306.1 3539539 D 585057 CDS YP_002409307.1 218701678 7152091 3540820..3542076 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88029453, 90323001, 3311747; Product type t : transporter; nucleoside transporter 3542076 nupG 7152091 nupG Escherichia coli IAI39 nucleoside transporter YP_002409307.1 3540820 D 585057 CDS YP_002409308.1 218701679 7152283 complement(3542125..3544260) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 87260820; Product type e : enzyme; ornithine decarboxylase 3544260 speC 7152283 speC Escherichia coli IAI39 ornithine decarboxylase YP_002409308.1 3542125 R 585057 CDS YP_002409309.1 218701680 7152881 3544653..3545360 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3545360 yqgA 7152881 yqgA Escherichia coli IAI39 hypothetical protein YP_002409309.1 3544653 D 585057 CDS YP_002409310.1 218701681 7150570 3545739..3547004 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Prophage integrase 3547004 int 7150570 int Escherichia coli IAI39 Prophage integrase YP_002409310.1 3545739 D 585057 CDS YP_002409311.1 218701682 7151830 3547230..3548303 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411725; Product type pe : putative enzyme; SHI-2 pathogenicity island protein 3548303 7151830 ECIAI39_3392 Escherichia coli IAI39 SHI-2 pathogenicity island protein YP_002409311.1 3547230 D 585057 CDS YP_002409312.1 218701683 7150159 3548833..3549108 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 3549108 insA 7150159 insA Escherichia coli IAI39 IS1 repressor protein InsA YP_002409312.1 3548833 D 585057 CDS YP_002409313.1 218701684 7151787 3549027..3549530 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 3549530 insB 7151787 insB Escherichia coli IAI39 IS1 transposase InsAB' YP_002409313.1 3549027 D 585057 CDS YP_002409314.1 218701685 7151798 complement(3549997..3550548) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative HTH-type transcriptional regulator 3550548 7151798 ECIAI39_3395 Escherichia coli IAI39 putative HTH-type transcriptional regulator YP_002409314.1 3549997 R 585057 CDS YP_002409315.1 218701686 7150160 complement(3550715..3551083) 1 NC_011750.1 hypothetical protein 3551083 7150160 ECIAI39_3396 Escherichia coli IAI39 hypothetical protein YP_002409315.1 3550715 R 585057 CDS YP_002409316.1 218701687 7150161 complement(3551553..3551804) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase ORF A, IS3 family 3551804 7150161 ECIAI39_3397 Escherichia coli IAI39 putative transposase ORF A, IS3 family YP_002409316.1 3551553 R 585057 CDS YP_002409317.1 218701688 7152340 complement(3553058..3553591) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2869489, 2895103, 1357526, 8096174, 10049807; Product type s : structure; fimbrial adapter PapF 3553591 papF 7152340 papF Escherichia coli IAI39 fimbrial adapter PapF YP_002409317.1 3553058 R 585057 CDS YP_002409318.1 218701689 7152337 complement(3553636..3554175) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2869489, 2895103, 1357526, 10049807; Product type s : structure; fimbrial tip protein PapE 3554175 papE 7152337 papE Escherichia coli IAI39 fimbrial tip protein PapE YP_002409318.1 3553636 R 585057 CDS YP_002409319.1 218701690 7152335 complement(3554212..3554715) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 3554715 insB 7152335 insB Escherichia coli IAI39 IS1 transposase InsAB' YP_002409319.1 3554212 R 585057 CDS YP_002409320.1 218701691 7151799 complement(3554634..3554909) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 3554909 insA 7151799 insA Escherichia coli IAI39 IS1 repressor protein InsA YP_002409320.1 3554634 R 585057 CDS YP_002409321.1 218701692 7152331 3556432..3556665 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2868893, 1357526; Product type r : regulator; pap operon regulatory protein PapI 3556665 papI 7152331 papI Escherichia coli IAI39 pap operon regulatory protein PapI YP_002409321.1 3556432 D 585057 CDS YP_002409322.1 218701693 7152343 complement(3556811..3557257) 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 3557257 7152343 ECIAI39_3408 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002409322.1 3556811 R 585057 CDS YP_002409323.1 218701694 7150542 complement(3557374..3558897) 1 NC_011750.1 Group II intron-encoded reverse transcriptase/maturase 3558897 7150542 ECIAI39_3409 Escherichia coli IAI39 Group II intron-encoded reverse transcriptase/maturase YP_002409323.1 3557374 R 585057 CDS YP_002409324.1 218701695 7150164 complement(3559489..3559779) 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 3559779 7150164 ECIAI39_3410 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002409324.1 3559489 R 585057 CDS YP_002409325.1 218701696 7150167 3561115..3561915 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase IstB, IS21 3561915 7150167 ECIAI39_3413 Escherichia coli IAI39 transposase IstB, IS21 YP_002409325.1 3561115 D 585057 CDS YP_002409326.1 218701697 7150168 complement(3561955..3562104) 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 3562104 7150168 ECIAI39_3414 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002409326.1 3561955 R 585057 CDS YP_002409327.1 218701698 7150169 complement(3562104..3562430) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 3562430 7150169 ECIAI39_3415 Escherichia coli IAI39 transposase ORF A, IS629 YP_002409327.1 3562104 R 585057 CDS YP_002409328.1 218701699 7150170 complement(3563170..3563916) 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; putative transposase (fragment) 3563916 7150170 ECIAI39_3416 Escherichia coli IAI39 putative transposase (fragment) YP_002409328.1 3563170 R 585057 CDS YP_002409329.1 218701700 7150171 3564462..3564728 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3564728 7150171 ECIAI39_3417 Escherichia coli IAI39 hypothetical protein YP_002409329.1 3564462 D 585057 CDS YP_002409330.1 218701701 7150172 3564770..3565330 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative transcriptional regulator 3565330 7150172 ECIAI39_3418 Escherichia coli IAI39 putative transcriptional regulator YP_002409330.1 3564770 D 585057 CDS YP_002409331.1 218701702 7150173 3565340..3565798 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3565798 7150173 ECIAI39_3419 Escherichia coli IAI39 hypothetical protein YP_002409331.1 3565340 D 585057 CDS YP_002409332.1 218701703 7150174 3566462..3566836 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type r : regulator; IS2 insertion element repressor InsA; KpLE2 phage-like element 3566836 insC 7150174 insC Escherichia coli IAI39 IS2 insertion element repressor InsA; KpLE2 phage-like element YP_002409332.1 3566462 D 585057 CDS YP_002409333.1 218701704 7151804 3566829..3567734 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS2 insertion element transposase InsAB'; CP4-44 prophage 3567734 insD 7151804 insD Escherichia coli IAI39 IS2 insertion element transposase InsAB'; CP4-44 prophage YP_002409333.1 3566829 D 585057 CDS YP_002409334.1 218701705 7151807 complement(3567847..3569040) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411725; Product type pt : putative transporter; putative membrane transport protein, major facilitator superfamily 3569040 shiF 7151807 shiF Escherichia coli IAI39 putative membrane transport protein, major facilitator superfamily YP_002409334.1 3567847 R 585057 CDS YP_002409335.1 218701706 7152851 3569110..3570900 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3087960; Product type e : enzyme; aerobactin siderophore biosynthesis protein 3570900 iucA 7152851 iucA Escherichia coli IAI39 aerobactin siderophore biosynthesis protein YP_002409335.1 3569110 D 585057 CDS YP_002409336.1 218701707 7151862 3570901..3571848 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3087960; Product type e : enzyme; aerobactin siderophore biosynthesis N(6)-hydroxylysine acetylase 3571848 iucB 7151862 iucB Escherichia coli IAI39 aerobactin siderophore biosynthesis N(6)-hydroxylysine acetylase YP_002409336.1 3570901 D 585057 CDS YP_002409337.1 218701708 7151863 3571848..3573590 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3087960; Product type e : enzyme; Aerobactin siderophore biosynthesis protein 3573590 iucC 7151863 iucC Escherichia coli IAI39 Aerobactin siderophore biosynthesis protein YP_002409337.1 3571848 D 585057 CDS YP_002409338.1 218701709 7151864 3573587..3574864 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3275632, 10064136; Product type e : enzyme; L-lysine 6-monooxygenase 3574864 iucD 7151864 iucD Escherichia coli IAI39 L-lysine 6-monooxygenase YP_002409338.1 3573587 D 585057 CDS YP_002409339.1 218701710 7151865 3574946..3577147 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4313071, 6456229, 7044820, 7042696, 6749806; Product type rc : receptor; Ferric aerobactin receptor 3577147 iutA 7151865 iutA Escherichia coli IAI39 Ferric aerobactin receptor YP_002409339.1 3574946 D 585057 CDS YP_002409340.1 218701711 7152803 3580474..3580800 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 3580800 7152803 ECIAI39_3429 Escherichia coli IAI39 transposase ORF A, IS629 YP_002409340.1 3580474 D 585057 CDS YP_002409341.1 218701712 7150175 3580797..3581279 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 3581279 7150175 ECIAI39_3430 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002409341.1 3580797 D 585057 CDS YP_002409342.1 218701713 7150176 3581871..3583394 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9353259, 10413481; Product type e : enzyme; Group II intron-encoded reverse transcriptase/maturase 3583394 7150176 ECIAI39_3431 Escherichia coli IAI39 Group II intron-encoded reverse transcriptase/maturase YP_002409342.1 3581871 D 585057 CDS YP_002409343.1 218701714 7150543 3583511..3583957 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 3583957 7150543 ECIAI39_3432 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002409343.1 3583511 D 585057 CDS YP_002409344.1 218701715 7151903 3584271..3585419 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8253690; Product type t : transporter; capsule polysaccharide export inner-membrane protein 3585419 kpsE 7151903 kpsE Escherichia coli IAI39 capsule polysaccharide export inner-membrane protein YP_002409344.1 3584271 D 585057 CDS YP_002409345.1 218701716 7151902 3585440..3587119 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8021185; Product type t : transporter; polysialic acid transport protein 3587119 kpsD 7151902 kpsD Escherichia coli IAI39 polysialic acid transport protein YP_002409345.1 3585440 D 585057 CDS YP_002409346.1 218701717 7151901 3587129..3587869 1 NC_011750.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 3587869 kpsU 7151901 kpsU Escherichia coli IAI39 3-deoxy-manno-octulosonate cytidylyltransferase YP_002409346.1 3587129 D 585057 CDS YP_002409347.1 218701718 7151907 3587866..3589893 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8397187, 8326861; Product type t : transporter; capsule polysaccharide export protein 3589893 kpsC 7151907 kpsC Escherichia coli IAI39 capsule polysaccharide export protein YP_002409347.1 3587866 D 585057 CDS YP_002409348.1 218701719 7151900 3589928..3591133 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8397187, 8326861; Product type t : transporter; capsule polysaccharide export protein 3591133 kpsS 7151900 kpsS Escherichia coli IAI39 capsule polysaccharide export protein YP_002409348.1 3589928 D 585057 CDS YP_002409349.1 218701720 7151905 complement(3591283..3592512) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme; poly-alpha-2,8 sialosyl sialyltransferase 3592512 neuS 7151905 neuS Escherichia coli IAI39 poly-alpha-2,8 sialosyl sialyltransferase YP_002409349.1 3591283 R 585057 CDS YP_002409350.1 218701721 7152212 complement(3592502..3593650) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 16484189, 1735705; Product type e : enzyme; polysialic acid biosynthesis protein 3593650 neuE 7152212 neuE Escherichia coli IAI39 polysialic acid biosynthesis protein YP_002409350.1 3592502 R 585057 CDS YP_002409351.1 218701722 7152210 complement(3593643..3594818) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14729696, 1729218; Product type e : enzyme; UDP-N-acetylglucosamine 2-epimerase 3594818 neuC 7152210 neuC Escherichia coli IAI39 UDP-N-acetylglucosamine 2-epimerase YP_002409351.1 3593643 R 585057 CDS YP_002409352.1 218701723 7152208 complement(3594815..3596071) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2549035; Product type e : enzyme; N-acylneuraminate cytidylyltransferase 3596071 neuA 7152208 neuA Escherichia coli IAI39 N-acylneuraminate cytidylyltransferase YP_002409352.1 3594815 R 585057 CDS YP_002409353.1 218701724 7152206 complement(3596071..3597111) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7814319; Product type e : enzyme; N-acylneuraminate-9-phosphate synthase 3597111 neuB 7152206 neuB Escherichia coli IAI39 N-acylneuraminate-9-phosphate synthase YP_002409353.1 3596071 R 585057 CDS YP_002409354.1 218701725 7152207 complement(3597108..3597731) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10930752, 7814319; Product type e : enzyme; NeuD protein involved in sialic acid synthesis 3597731 neuD 7152207 neuD Escherichia coli IAI39 NeuD protein involved in sialic acid synthesis YP_002409354.1 3597108 R 585057 CDS YP_002409355.1 218701726 7152209 complement(3597781..3598440) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1856162, 8051103, 2082146; Product type t : transporter; polysialic acid transport ATP-binding protein 3598440 kpsT 7152209 kpsT Escherichia coli IAI39 polysialic acid transport ATP-binding protein YP_002409355.1 3597781 R 585057 CDS YP_002409356.1 218701727 7151906 complement(3598437..3599273) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1856162, 7715449; Product type t : transporter; polysialic acid transport protein 3599273 kpsM 7151906 kpsM Escherichia coli IAI39 polysialic acid transport protein YP_002409356.1 3598437 R 585057 CDS YP_002409357.1 218701728 7151904 complement(3600272..3600808) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative general secretion pathway protein YghD 3600808 yghD 7151904 yghD Escherichia coli IAI39 putative general secretion pathway protein YghD YP_002409357.1 3600272 R 585057 CDS YP_002409358.1 218701729 7153999 complement(3600810..3601988) 1 NC_011750.1 similar to general secretory pathway protein L; GspL-like protein 3601988 yghE 7153999 yghE Escherichia coli IAI39 GspL-like protein YP_002409358.1 3600810 R 585057 CDS YP_002409359.1 218701730 7154000 complement(3601985..3602962) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; GspK-like type II secretion protein 3602962 7154000 ECIAI39_3449 Escherichia coli IAI39 GspK-like type II secretion protein YP_002409359.1 3601985 R 585057 CDS YP_002409360.1 218701731 7150179 complement(3602959..3603564) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3603564 7150179 ECIAI39_3450 Escherichia coli IAI39 hypothetical protein YP_002409360.1 3602959 R 585057 CDS YP_002409361.1 218701732 7150180 complement(3603561..3603932) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative GspI-like type II secretion protein 3603932 7150180 ECIAI39_3451 Escherichia coli IAI39 putative GspI-like type II secretion protein YP_002409361.1 3603561 R 585057 CDS YP_002409362.1 218701733 7150181 complement(3603929..3604492) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3604492 7150181 ECIAI39_3452 Escherichia coli IAI39 hypothetical protein YP_002409362.1 3603929 R 585057 CDS YP_002409363.1 218701734 7150182 complement(3604496..3604978) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative general secretion pathway protein G (epsG-like) 3604978 7150182 ECIAI39_3453 Escherichia coli IAI39 putative general secretion pathway protein G (epsG-like) YP_002409363.1 3604496 R 585057 CDS YP_002409364.1 218701735 7150183 complement(3604968..3606191) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; General secretion pathway protein F 3606191 epsF 7150183 epsF Escherichia coli IAI39 General secretion pathway protein F YP_002409364.1 3604968 R 585057 CDS YP_002409365.1 218701736 7151235 complement(3606191..3607684) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; general secretion pathway protein E 3607684 epsE 7151235 epsE Escherichia coli IAI39 general secretion pathway protein E YP_002409365.1 3606191 R 585057 CDS YP_002409366.1 218701737 7151234 complement(3607684..3609744) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; general secretion pathway protein D 3609744 epsD 7151234 epsD Escherichia coli IAI39 general secretion pathway protein D YP_002409366.1 3607684 R 585057 CDS YP_002409367.1 218701738 7151233 complement(3609774..3610733) 1 NC_011750.1 part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm; putative type II secretion protein GspC 3610733 yghF 7151233 yghF Escherichia coli IAI39 putative type II secretion protein GspC YP_002409367.1 3609774 R 585057 CDS YP_002409368.1 218701739 7154001 complement(3610751..3611161) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3611161 yghG 7154001 yghG Escherichia coli IAI39 hypothetical protein YP_002409368.1 3610751 R 585057 CDS YP_002409369.1 218701740 7154002 complement(3611227..3612036) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98175453; Product type e : enzyme; bifunctional prepilin leader peptidase and methylase 3612036 pppA 7154002 pppA Escherichia coli IAI39 bifunctional prepilin leader peptidase and methylase YP_002409369.1 3611227 R 585057 CDS YP_002409370.1 218701741 7152465 complement(3612166..3616740) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1644747; Product type lp : lipoprotein; inner membrane lipoprotein 3616740 yghJ 7152465 yghJ Escherichia coli IAI39 inner membrane lipoprotein YP_002409370.1 3612166 R 585057 CDS YP_002409371.1 218701742 7154003 3616873..3617073 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3617073 7154003 ECIAI39_3461 Escherichia coli IAI39 hypothetical protein YP_002409371.1 3616873 D 585057 CDS YP_002409372.1 218701743 7150184 complement(3617207..3618889) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11785976, 21178909, 11283302; Product type t : transporter; glycolate transporter 3618889 yghK 7150184 yghK Escherichia coli IAI39 glycolate transporter YP_002409372.1 3617207 R 585057 CDS YP_002409373.1 218701744 7150889 complement(3619244..3621415) 1 NC_011750.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G 3621415 glcB 7150889 glcB Escherichia coli IAI39 malate synthase G YP_002409373.1 3619244 R 585057 CDS YP_002409374.1 218701745 7151505 complement(3621437..3621841) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3621841 glcG 7151505 glcG Escherichia coli IAI39 hypothetical protein YP_002409374.1 3621437 R 585057 CDS YP_002409375.1 218701746 7151510 complement(3621846..3623069) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type c : carrier; glycolate oxidase iron-sulfur subunit 3623069 glcF 7151510 glcF Escherichia coli IAI39 glycolate oxidase iron-sulfur subunit YP_002409375.1 3621846 R 585057 CDS YP_002409376.1 218701747 7151509 complement(3623080..3624132) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type e : enzyme; glycolate oxidase FAD binding subunit 3624132 glcE 7151509 glcE Escherichia coli IAI39 glycolate oxidase FAD binding subunit YP_002409376.1 3623080 R 585057 CDS YP_002409377.1 218701748 7151508 complement(3624132..3625631) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type e : enzyme; glycolate oxidase subunit GlcD 3625631 glcD 7151508 glcD Escherichia coli IAI39 glycolate oxidase subunit GlcD YP_002409377.1 3624132 R 585057 CDS YP_002409378.1 218701749 7151507 3625882..3626646 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 9880556, 8606183; Product type r : regulator; DNA-binding transcriptional regulator GlcC 3626646 glcC 7151507 glcC Escherichia coli IAI39 DNA-binding transcriptional regulator GlcC YP_002409378.1 3625882 D 585057 CDS YP_002409379.1 218701750 7151506 complement(3626653..3627795) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3627795 yghO 7151506 yghO Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002409379.1 3626653 R 585057 CDS YP_002409380.1 218701751 7150185 3629884..3630798 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative epimerase 3630798 7150185 ECIAI39_3471 Escherichia coli IAI39 putative epimerase YP_002409380.1 3629884 D 585057 CDS YP_002409381.1 218701752 7150186 3630830..3631078 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3631078 7150186 ECIAI39_3472 Escherichia coli IAI39 hypothetical protein YP_002409381.1 3630830 D 585057 CDS YP_002409382.1 218701753 7150187 3631078..3632250 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 8-amino-7-oxononanoate synthase 3632250 7150187 ECIAI39_3473 Escherichia coli IAI39 putative 8-amino-7-oxononanoate synthase YP_002409382.1 3631078 D 585057 CDS YP_002409383.1 218701754 7150188 complement(3632285..3633364) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3633364 7150188 ECIAI39_3474 Escherichia coli IAI39 hypothetical protein YP_002409383.1 3632285 R 585057 CDS YP_002409384.1 218701755 7150189 complement(3633361..3634431) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3634431 7150189 ECIAI39_3475 Escherichia coli IAI39 hypothetical protein YP_002409384.1 3633361 R 585057 CDS YP_002409385.1 218701756 7150190 complement(3634462..3635025) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3635025 7150190 ECIAI39_3476 Escherichia coli IAI39 putative transcriptional regulator YP_002409385.1 3634462 R 585057 CDS YP_002409386.1 218701757 7150191 complement(3635034..3635858) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3635858 7150191 ECIAI39_3477 Escherichia coli IAI39 hypothetical protein YP_002409386.1 3635034 R 585057 CDS YP_002409387.1 218701758 7150192 complement(3635858..3637207) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 3637207 7150192 ECIAI39_3478 Escherichia coli IAI39 hypothetical protein YP_002409387.1 3635858 R 585057 CDS YP_002409388.1 218701759 7150193 complement(3637253..3638011) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3638011 yghR 7150193 yghR Escherichia coli IAI39 hypothetical protein YP_002409388.1 3637253 R 585057 CDS YP_002409389.1 218701760 7154006 complement(3638043..3638756) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3638756 yghS 7154006 yghS Escherichia coli IAI39 hypothetical protein YP_002409389.1 3638043 R 585057 CDS YP_002409390.1 218701761 7154009 complement(3639670..3641169) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21336523, 21382172, 7775463; Product type t : transporter; phosphate transporter 3641169 pitB 7154009 pitB Escherichia coli IAI39 phosphate transporter YP_002409390.1 3639670 R 585057 CDS YP_002409391.1 218701762 7152424 complement(3641461..3643320) 1 NC_011750.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase 3643320 gss 7152424 gss Escherichia coli IAI39 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase YP_002409391.1 3641461 R 585057 CDS YP_002409392.1 218701763 7151594 3643525..3644391 1 NC_011750.1 YghU; B2989; one of eight putative glutathione transferase proteins from E. coli; putative glutathione S-transferase YghU 3644391 yghU 7151594 yghU Escherichia coli IAI39 putative glutathione S-transferase YghU YP_002409392.1 3643525 D 585057 CDS YP_002409393.1 218701764 7154010 complement(3644461..3644709) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 94292472, 8021226; Product type pf : putative factor; hydrogenase 2 accessory protein HypG 3644709 hybG 7154010 hybG Escherichia coli IAI39 hydrogenase 2 accessory protein HypG YP_002409393.1 3644461 R 585057 CDS YP_002409394.1 218701765 7151709 complement(3644722..3645063) 1 NC_011750.1 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF 3645063 hybF 7151709 hybF Escherichia coli IAI39 hydrogenase nickel incorporation protein HybF YP_002409394.1 3644722 R 585057 CDS YP_002409395.1 218701766 7151708 complement(3645056..3645544) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94292472, 8021226; Product type f : factor; hydrogenase 2-specific chaperone 3645544 hybE 7151708 hybE Escherichia coli IAI39 hydrogenase 2-specific chaperone YP_002409395.1 3645056 R 585057 CDS YP_002409396.1 218701767 7151707 complement(3645537..3646031) 1 NC_011750.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase 3646031 hybD 7151707 hybD Escherichia coli IAI39 hydrogenase 2 maturation endopeptidase YP_002409396.1 3645537 R 585057 CDS YP_002409397.1 218701768 7151706 complement(3646031..3647734) 1 NC_011750.1 involved in hydrogen uptake; hydrogenase 2 large subunit 3647734 hybC 7151706 hybC Escherichia coli IAI39 hydrogenase 2 large subunit YP_002409397.1 3646031 R 585057 CDS YP_002409398.1 218701769 7151705 complement(3647731..3648909) 1 NC_011750.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; putative hydrogenase 2 b cytochrome subunit 3648909 hybB 7151705 hybB Escherichia coli IAI39 putative hydrogenase 2 b cytochrome subunit YP_002409398.1 3647731 R 585057 CDS YP_002409399.1 218701770 7151704 complement(3648899..3649885) 1 NC_011750.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA 3649885 hybA 7151704 hybA Escherichia coli IAI39 hydrogenase 2 protein HybA YP_002409399.1 3648899 R 585057 CDS YP_002409400.1 218701771 7151703 complement(3649888..3651006) 1 NC_011750.1 involved in hydrogen uptake; hydrogenase 2 small subunit 3651006 hybO 7151703 hybO Escherichia coli IAI39 hydrogenase 2 small subunit YP_002409400.1 3649888 R 585057 CDS YP_002409401.1 218701772 7151710 complement(3651013..3651198) 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 3651198 7151710 ECIAI39_3494 Escherichia coli IAI39 hypothetical protein YP_002409401.1 3651013 R 585057 CDS YP_002409402.1 218701773 7150194 complement(3651195..3651482) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3651482 yghW 7150194 yghW Escherichia coli IAI39 hypothetical protein YP_002409402.1 3651195 R 585057 CDS YP_002409403.1 218701774 7154011 complement(3651601..3652533) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3652533 7154011 ECIAI39_3496 Escherichia coli IAI39 hypothetical protein YP_002409403.1 3651601 R 585057 CDS YP_002409404.1 218701775 7150195 3652645..3653685 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12583903; Product type e : enzyme; aldo-keto reductase 3653685 yghZ 7150195 yghZ Escherichia coli IAI39 aldo-keto reductase YP_002409404.1 3652645 D 585057 CDS YP_002409405.1 218701776 7154012 complement(3653725..3654219) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3654219 yqhA 7154012 yqhA Escherichia coli IAI39 hypothetical protein YP_002409405.1 3653725 R 585057 CDS YP_002409406.1 218701777 7154518 3654410..3655294 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; oxidoreductase 3655294 yghA 7154518 yghA Escherichia coli IAI39 oxidoreductase YP_002409406.1 3654410 D 585057 CDS YP_002409407.1 218701778 7153997 complement(3655333..3655758) 1 NC_011750.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD 3655758 exbD 7153997 exbD Escherichia coli IAI39 biopolymer transport protein ExbD YP_002409407.1 3655333 R 585057 CDS YP_002409408.1 218701779 7151258 complement(3655765..3656499) 1 NC_011750.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB 3656499 exbB 7151258 exbB Escherichia coli IAI39 biopolymer transport protein ExbB YP_002409408.1 3655765 R 585057 CDS YP_002409409.1 218701780 7151257 3656751..3657938 1 NC_011750.1 catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3657938 metC 7151257 metC Escherichia coli IAI39 cystathionine beta-lyase YP_002409409.1 3656751 D 585057 CDS YP_002409410.1 218701781 7152052 3658078..3658737 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3658737 yghB 7152052 yghB Escherichia coli IAI39 hypothetical protein YP_002409410.1 3658078 D 585057 CDS YP_002409411.1 218701782 7153998 complement(3658777..3659733) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3659733 yqhC 7153998 yqhC Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002409411.1 3658777 R 585057 CDS YP_002409412.1 218701783 7154519 3659870..3661033 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15327949; Product type e : enzyme; alcohol dehydrogenase, NAD(P)-dependent 3661033 yqhD 7154519 yqhD Escherichia coli IAI39 alcohol dehydrogenase, NAD(P)-dependent YP_002409412.1 3659870 D 585057 CDS YP_002409413.1 218701784 7154520 3661138..3661965 1 NC_011750.1 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3661965 dkgA 7154520 dkgA Escherichia coli IAI39 2,5-diketo-D-gluconate reductase A YP_002409413.1 3661138 D 585057 CDS YP_002409414.1 218701785 7151145 3662165..3663091 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3663091 yqhG 7151145 yqhG Escherichia coli IAI39 hypothetical protein YP_002409414.1 3662165 D 585057 CDS YP_002409415.1 218701786 7154521 3663142..3663399 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative outer membrane lipoprotein 3663399 yqhH 7154521 yqhH Escherichia coli IAI39 putative outer membrane lipoprotein YP_002409415.1 3663142 D 585057 CDS YP_002409416.1 218701787 7154522 complement(3663442..3665661) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3665661 ygiQ 7154522 ygiQ Escherichia coli IAI39 hypothetical protein YP_002409416.1 3663442 R 585057 CDS YP_002409417.1 218701788 7154021 complement(3665772..3667184) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88314889, 1557036, 9298646; Product type r : regulator; repressor protein for FtsI 3667184 sufI 7154021 sufI Escherichia coli IAI39 repressor protein for FtsI YP_002409417.1 3665772 R 585057 CDS YP_002409418.1 218701789 7152927 complement(3667259..3667996) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92212294, 1557036; Product type e : enzyme; 1-acyl-sn-glycerol-3-phosphate acyltransferase 3667996 plsC 7152927 plsC Escherichia coli IAI39 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_002409418.1 3667259 R 585057 CDS YP_002409419.1 218701790 7152428 complement(3668044..3668199) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3668199 7152428 ECIAI39_3512 Escherichia coli IAI39 hypothetical protein YP_002409419.1 3668044 R 585057 CDS YP_002409420.1 218701791 7150196 complement(3668230..3670488) 1 NC_011750.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 3670488 parC 7150196 parC Escherichia coli IAI39 DNA topoisomerase IV subunit A YP_002409420.1 3668230 R 585057 CDS YP_002409421.1 218701792 7152347 complement(3670626..3672233) 1 NC_011750.1 YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system; putative binding protein 3672233 ygiS 7152347 ygiS Escherichia coli IAI39 putative binding protein YP_002409421.1 3670626 R 585057 CDS YP_002409422.1 218701793 7154022 complement(3672366..3672761) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3672761 ygiT 7154022 ygiT Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002409422.1 3672366 R 585057 CDS YP_002409423.1 218701794 7154023 complement(3672763..3673059) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16352847, 12952533, 14727089; Product type r : regulator; motility quorum-sensing regulator 3673059 mqsR 7154023 mqsR Escherichia coli IAI39 motility quorum-sensing regulator YP_002409423.1 3672763 R 585057 CDS YP_002409424.1 218701795 7152118 complement(3673264..3673746) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3673746 ygiV 7152118 ygiV Escherichia coli IAI39 putative transcriptional regulator YP_002409424.1 3673264 R 585057 CDS YP_002409425.1 218701796 7154024 complement(3673799..3674191) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9298646; hypothetical protein 3674191 ygiW 7154024 ygiW Escherichia coli IAI39 hypothetical protein YP_002409425.1 3673799 R 585057 CDS YP_002409426.1 218701797 7154025 3674343..3675002 1 NC_011750.1 response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3675002 qseB 7154025 qseB Escherichia coli IAI39 DNA-binding transcriptional regulator QseB YP_002409426.1 3674343 D 585057 CDS YP_002409427.1 218701798 7152558 3674999..3676348 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21927389; Product type r : regulator; sensor protein QseC 3676348 qseC 7152558 qseC Escherichia coli IAI39 sensor protein QseC YP_002409427.1 3674999 D 585057 CDS YP_002409428.1 218701799 7152559 complement(3676394..3676726) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3676726 ygiZ 7152559 ygiZ Escherichia coli IAI39 hypothetical protein YP_002409428.1 3676394 R 585057 CDS YP_002409429.1 218701800 7154026 complement(3676733..3677470) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3677470 7154026 ECIAI39_3523 Escherichia coli IAI39 hypothetical protein YP_002409429.1 3676733 R 585057 CDS YP_002409430.1 218701801 7150197 complement(3677446..3677925) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3677925 7150197 ECIAI39_3524 Escherichia coli IAI39 hypothetical protein YP_002409430.1 3677446 R 585057 CDS YP_002409431.1 218701802 7150198 3678175..3678756 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96004656, 96217538; Product type c : carrier; NADPH quinone reductase 3678756 mdaB 7150198 mdaB Escherichia coli IAI39 NADPH quinone reductase YP_002409431.1 3678175 D 585057 CDS YP_002409432.1 218701803 7152020 3678787..3679101 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10493123, 9298646, 9600841, 9868784; Product type e : enzyme; quinol monooxygenase 3679101 ygiN 7152020 ygiN Escherichia coli IAI39 quinol monooxygenase YP_002409432.1 3678787 D 585057 CDS YP_002409433.1 218701804 7154019 complement(3679149..3681041) 1 NC_011750.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 3681041 parE 7154019 parE Escherichia coli IAI39 DNA topoisomerase IV subunit B YP_002409433.1 3679149 R 585057 CDS YP_002409434.1 218701805 7152348 complement(3681070..3681651) 1 NC_011750.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YqiA 3681651 yqiA 7152348 yqiA Escherichia coli IAI39 esterase YqiA YP_002409434.1 3681070 R 585057 CDS YP_002409435.1 218701806 7154523 complement(3681651..3682478) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96411758; Product type e : enzyme; cyclic 3',5'-adenosine monophosphate phosphodiesterase 3682478 cpdA 7154523 cpdA Escherichia coli IAI39 cyclic 3',5'-adenosine monophosphate phosphodiesterase YP_002409435.1 3681651 R 585057 CDS YP_002409436.1 218701807 7150984 complement(3682503..3682925) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3682925 yqiB 7150984 yqiB Escherichia coli IAI39 hypothetical protein YP_002409436.1 3682503 R 585057 CDS YP_002409437.1 218701808 7154524 complement(3682926..3683555) 1 NC_011750.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase NudF 3683555 nudF 7154524 nudF Escherichia coli IAI39 ADP-ribose pyrophosphatase NudF YP_002409437.1 3682926 R 585057 CDS YP_002409438.1 218701809 7152266 3683760..3685241 1 NC_011750.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3685241 tolC 7152266 tolC Escherichia coli IAI39 outer membrane channel protein YP_002409438.1 3683760 D 585057 CDS YP_002409439.1 218701810 7152998 3685485..3686060 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3686060 ygiB 7152998 ygiB Escherichia coli IAI39 hypothetical protein YP_002409439.1 3685485 D 585057 CDS YP_002409440.1 218701811 7154013 3686066..3687226 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3687226 ygiC 7154013 ygiC Escherichia coli IAI39 hypothetical protein YP_002409440.1 3686066 D 585057 CDS YP_002409441.1 218701812 7154014 complement(3687264..3688079) 1 NC_011750.1 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein 3688079 zupT 7154014 zupT Escherichia coli IAI39 hypothetical protein YP_002409441.1 3687264 R 585057 CDS YP_002409442.1 218701813 7154598 3688195..3688968 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11790762, 1314093; Product type t : transporter; zinc transporter ZupT 3688968 ygiE 7154598 ygiE Escherichia coli IAI39 zinc transporter ZupT YP_002409442.1 3688195 D 585057 CDS YP_002409443.1 218701814 7154015 complement(3689026..3689220) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3689220 7154015 ECIAI39_3537 Escherichia coli IAI39 hypothetical protein YP_002409443.1 3689026 R 585057 CDS YP_002409444.1 218701815 7150199 complement(3689458..3690111) 1 NC_011750.1 DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase 3690111 ribB 7150199 ribB Escherichia coli IAI39 3,4-dihydroxy-2-butanone 4-phosphate synthase YP_002409444.1 3689458 R 585057 CDS YP_002409445.1 218701816 7150544 3690485..3690775 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3690775 yqiC 7150544 yqiC Escherichia coli IAI39 hypothetical protein YP_002409445.1 3690485 D 585057 CDS YP_002409446.1 218701817 7154525 3691059..3691610 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial protein 3691610 ygiL 7154525 ygiL Escherichia coli IAI39 putative fimbrial protein YP_002409446.1 3691059 D 585057 CDS YP_002409447.1 218701818 7154527 3694190..3694939 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; periplasmic pilin chaperone 3694939 yqiH 7154527 yqiH Escherichia coli IAI39 periplasmic pilin chaperone YP_002409447.1 3694190 D 585057 CDS YP_002409448.1 218701819 7154528 3694941..3696005 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3696005 yqiI 7154528 yqiI Escherichia coli IAI39 hypothetical protein YP_002409448.1 3694941 D 585057 CDS YP_002409449.1 218701820 7154529 complement(3696048..3696248) 1 NC_011750.1 Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS 3696248 glgS 7154529 glgS Escherichia coli IAI39 glycogen synthesis protein GlgS YP_002409449.1 3696048 R 585057 CDS YP_002409450.1 218701821 7151516 3696517..3697146 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3697146 yqiJ 7151516 yqiJ Escherichia coli IAI39 hypothetical protein YP_002409450.1 3696517 D 585057 CDS YP_002409451.1 218701822 7154530 3697173..3698834 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3698834 yqiK 7154530 yqiK Escherichia coli IAI39 hypothetical protein YP_002409451.1 3697173 D 585057 CDS YP_002409452.1 218701823 7150545 complement(3699627..3701060) 1 NC_011750.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 3701060 rfaE 7150545 rfaE Escherichia coli IAI39 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase YP_002409452.1 3699627 R 585057 CDS YP_002409453.1 218701824 7152601 complement(3701108..3703948) 1 NC_011750.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 3703948 glnE 7152601 glnE Escherichia coli IAI39 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase YP_002409453.1 3701108 R 585057 CDS YP_002409454.1 218701825 7151526 complement(3703971..3705272) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8412694; Product type pe : putative enzyme; putative adenylate cyclase 3705272 ygiF 7151526 ygiF Escherichia coli IAI39 putative adenylate cyclase YP_002409454.1 3703971 R 585057 CDS YP_002409455.1 218701826 7154016 3705514..3706134 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11274153; Product type pr : putative regulator; putative signal transduction protein 3706134 htrG 7154016 htrG Escherichia coli IAI39 putative signal transduction protein YP_002409455.1 3705514 D 585057 CDS YP_002409456.1 218701827 7151690 3706198..3707436 1 NC_011750.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3707436 cca 7151690 cca Escherichia coli IAI39 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase YP_002409456.1 3706198 D 585057 CDS YP_002409457.1 218701828 7150908 complement(3707617..3708438) 1 NC_011750.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 3708438 bacA 7150908 bacA Escherichia coli IAI39 undecaprenyl pyrophosphate phosphatase YP_002409457.1 3707617 R 585057 CDS YP_002409458.1 218701829 7150833 complement(3708529..3708897) 1 NC_011750.1 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase 3708897 folB 7150833 folB Escherichia coli IAI39 bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase YP_002409458.1 3708529 R 585057 CDS YP_002409459.1 218701830 7151398 3709002..3709619 1 NC_011750.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY 3709619 plsY 7151398 plsY Escherichia coli IAI39 putative glycerol-3-phosphate acyltransferase PlsY YP_002409459.1 3709002 D 585057 CDS YP_002409460.1 218701831 7152430 complement(3709632..3710564) 1 NC_011750.1 activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol; transcriptional activator TtdR 3710564 ygiP 7152430 ygiP Escherichia coli IAI39 transcriptional activator TtdR YP_002409460.1 3709632 R 585057 CDS YP_002409461.1 218701832 7154020 3710771..3711682 1 NC_011750.1 Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 3711682 ttdA 7154020 ttdA Escherichia coli IAI39 tartrate dehydratase subunit alpha YP_002409461.1 3710771 D 585057 CDS YP_002409462.1 218701833 7153051 3711679..3712284 1 NC_011750.1 Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 3712284 ttdB 7153051 ttdB Escherichia coli IAI39 L(+)-tartrate dehydratase subunit beta YP_002409462.1 3711679 D 585057 CDS YP_002409463.1 218701834 7153052 3712333..3713796 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative tartrate:succinate antiporter 3713796 ygjE 7153052 ygjE Escherichia coli IAI39 putative tartrate:succinate antiporter YP_002409463.1 3712333 D 585057 CDS YP_002409464.1 218701835 7154027 complement(3713839..3714852) 1 NC_011750.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 3714852 gcp 7154027 gcp Escherichia coli IAI39 putative DNA-binding/iron metalloprotein/AP endonuclease YP_002409464.1 3713839 R 585057 CDS YP_002409465.1 218701836 7151494 3715089..3715304 1 NC_011750.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3715304 rpsU 7151494 rpsU Escherichia coli IAI39 30S ribosomal protein S21 YP_002409465.1 3715089 D 585057 CDS YP_002409466.1 218701837 7152733 3715415..3717160 1 NC_011750.1 synthesizes RNA primers at the replication forks; DNA primase 3717160 dnaG 7152733 dnaG Escherichia coli IAI39 DNA primase YP_002409466.1 3715415 D 585057 CDS YP_002409467.1 218701838 7151157 3717355..3719196 1 NC_011750.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3719196 rpoD 7151157 rpoD Escherichia coli IAI39 RNA polymerase sigma factor RpoD YP_002409467.1 3717355 D 585057 CDS YP_002409468.1 218701839 7152706 3719334..3720680 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element 3720680 insG 7152706 insG Escherichia coli IAI39 putative IS4 transposase; KpLE2 phage-like element YP_002409468.1 3719334 D 585057 CDS YP_002409469.1 218701840 7151815 complement(3720714..3721220) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20412902, 99453007, 6269063, 7567469, 8878487, 9489705; Product type e : enzyme; G/U mismatch-specific DNA glycosylase 3721220 ygjF 7151815 ygjF Escherichia coli IAI39 G/U mismatch-specific DNA glycosylase YP_002409469.1 3720714 R 585057 CDS YP_002409470.1 218701841 7150571 complement(3721473..3722237) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative siderophore interacting protein 3722237 yqjH 7150571 yqjH Escherichia coli IAI39 putative siderophore interacting protein YP_002409470.1 3721473 R 585057 CDS YP_002409471.1 218701842 7154539 3722449..3722979 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 3722979 7154539 ECIAI39_3567 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002409471.1 3722449 D 585057 CDS YP_002409472.1 218701843 7150200 3723084..3723806 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 3723806 7150200 ECIAI39_3568 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002409472.1 3723084 D 585057 CDS YP_002409473.1 218701844 7150201 3723961..3724584 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3724584 yqjI 7150201 yqjI Escherichia coli IAI39 putative transcriptional regulator YP_002409473.1 3723961 D 585057 CDS YP_002409474.1 218701845 7154540 complement(3724738..3726258) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20015410, 9380671, 9643537, 9190831; Product type r : regulator; fused signal transducer for aerotaxis sensory component ; methyl accepting chemotaxis component 3726258 aer 7154540 aer Escherichia coli IAI39 fused signal transducer for aerotaxis sensory component ; methyl accepting chemotaxis component YP_002409474.1 3724738 R 585057 CDS YP_002409475.1 218701846 7150695 3726649..3728055 1 NC_011750.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 3728055 ygjG 7150695 ygjG Escherichia coli IAI39 putrescine--2-oxoglutarate aminotransferase YP_002409475.1 3726649 D 585057 CDS YP_002409476.1 218701847 7154029 complement(3728097..3728429) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11101501; hypothetical protein 3728429 ygjH 7154029 ygjH Escherichia coli IAI39 hypothetical protein YP_002409476.1 3728097 R 585057 CDS YP_002409477.1 218701848 7154030 3728648..3729631 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89128452, 2515108, 3939708; Product type r : regulator; DNA-binding transcriptional repressor EbgR 3729631 ebgR 7154030 ebgR Escherichia coli IAI39 DNA-binding transcriptional repressor EbgR YP_002409477.1 3728648 D 585057 CDS YP_002409478.1 218701849 7151197 3729815..3732907 1 NC_011750.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 3732907 ebgA 7151197 ebgA Escherichia coli IAI39 cryptic beta-D-galactosidase subunit alpha YP_002409478.1 3729815 D 585057 CDS YP_002409479.1 218701850 7151195 3732904..3733353 1 NC_011750.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 3733353 ebgC 7151195 ebgC Escherichia coli IAI39 cryptic beta-D-galactosidase subunit beta YP_002409479.1 3732904 D 585057 CDS YP_002409480.1 218701851 7151196 3733416..3734849 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3734849 ygjI 7151196 ygjI Escherichia coli IAI39 putative transporter YP_002409480.1 3733416 D 585057 CDS YP_002409481.1 218701852 7154031 3734983..3736053 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3736053 ygjJ 7154031 ygjJ Escherichia coli IAI39 hypothetical protein YP_002409481.1 3734983 D 585057 CDS YP_002409482.1 218701853 7154032 3736070..3738421 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15213393; Product type pe : putative enzyme; putative glycosyl hydrolase 3738421 ygjK 7154032 ygjK Escherichia coli IAI39 putative glycosyl hydrolase YP_002409482.1 3736070 D 585057 CDS YP_002409483.1 218701854 7154033 3738947..3740965 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12840019, 89380266; Product type e : enzyme; 2,4-dienoyl-CoA reductase, NADH and FMN-linked 3740965 fadH 7154033 fadH Escherichia coli IAI39 2,4-dienoyl-CoA reductase, NADH and FMN-linked YP_002409483.1 3738947 D 585057 CDS YP_002409484.1 218701855 7151276 complement(3741083..3742219) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase small domain 3742219 ygjO 7151276 ygjO Escherichia coli IAI39 putative methyltransferase small domain YP_002409484.1 3741083 R 585057 CDS YP_002409485.1 218701856 7154034 3742304..3742807 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal dependent hydrolase 3742807 ygjP 7154034 ygjP Escherichia coli IAI39 putative metal dependent hydrolase YP_002409485.1 3742304 D 585057 CDS YP_002409486.1 218701857 7154035 3742884..3743567 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative thioredoxin-like 3743567 ygjQ 7154035 ygjQ Escherichia coli IAI39 putative thioredoxin-like YP_002409486.1 3742884 D 585057 CDS YP_002409487.1 218701858 7154036 3743628..3744632 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P)-binding dehydrogenase 3744632 ygjR 7154036 ygjR Escherichia coli IAI39 putative NAD(P)-binding dehydrogenase YP_002409487.1 3743628 D 585057 CDS YP_002409488.1 218701859 7152894 3744915..3745880 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12107143, 2108134; Product type pm : putative membrane component; hypothetical protein 3745880 alx 7152894 alx Escherichia coli IAI39 hypothetical protein YP_002409488.1 3744915 D 585057 CDS YP_002409489.1 218701860 7150724 3746496..3747740 1 NC_011750.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3747740 sstT 7150724 sstT Escherichia coli IAI39 serine/threonine transporter SstT YP_002409489.1 3746496 D 585057 CDS YP_002409490.1 218701861 7152910 complement(3747745..3748296) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3748296 ygjV 7152910 ygjV Escherichia coli IAI39 hypothetical protein YP_002409490.1 3747745 R 585057 CDS YP_002409491.1 218701862 7154038 complement(3748379..3749866) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4570160, 83114543, 3038546; Product type e : enzyme; altronate hydrolase 3749866 uxaA 7154038 uxaA Escherichia coli IAI39 altronate hydrolase YP_002409491.1 3748379 R 585057 CDS YP_002409492.1 218701863 7153118 complement(3749881..3751293) 1 NC_011750.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase 3751293 uxaC 7153118 uxaC Escherichia coli IAI39 glucuronate isomerase YP_002409492.1 3749881 R 585057 CDS YP_002409493.1 218701864 7153120 3751656..3753074 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83218546, 98190790; Product type t : transporter; hexuronate transporter 3753074 exuT 7153120 exuT Escherichia coli IAI39 hexuronate transporter YP_002409493.1 3751656 D 585057 CDS YP_002409494.1 218701865 7151262 complement(3753167..3754255) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative minor pilin and initiator 3754255 7151262 ECIAI39_3591 Escherichia coli IAI39 putative minor pilin and initiator YP_002409494.1 3753167 R 585057 CDS YP_002409495.1 218701866 7150202 complement(3754252..3756954) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3756954 7150202 ECIAI39_3592 Escherichia coli IAI39 hypothetical protein YP_002409495.1 3754252 R 585057 CDS YP_002409496.1 218701867 7150203 complement(3757027..3757527) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative adhesin major subunit pilin 3757527 7150203 ECIAI39_3593 Escherichia coli IAI39 putative adhesin major subunit pilin YP_002409496.1 3757027 R 585057 CDS YP_002409497.1 218701868 7150204 complement(3757557..3758273) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial protein 3758273 7150204 ECIAI39_3594 Escherichia coli IAI39 putative fimbrial protein YP_002409497.1 3757557 R 585057 CDS YP_002409498.1 218701869 7150205 3758569..3759345 1 NC_011750.1 regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 3759345 exuR 7150205 exuR Escherichia coli IAI39 DNA-binding transcriptional repressor ExuR YP_002409498.1 3758569 D 585057 CDS YP_002409499.1 218701870 7151261 3759690..3760352 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3760352 yqjA 7151261 yqjA Escherichia coli IAI39 hypothetical protein YP_002409499.1 3759690 D 585057 CDS YP_002409500.1 218701871 7154532 3760356..3760739 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3760739 yqjB 7154532 yqjB Escherichia coli IAI39 hypothetical protein YP_002409500.1 3760356 D 585057 CDS YP_002409501.1 218701872 7154533 3760886..3761254 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3761254 yqjC 7154533 yqjC Escherichia coli IAI39 hypothetical protein YP_002409501.1 3760886 D 585057 CDS YP_002409502.1 218701873 7154534 3761292..3761597 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3761597 yqjD 7154534 yqjD Escherichia coli IAI39 hypothetical protein YP_002409502.1 3761292 D 585057 CDS YP_002409503.1 218701874 7154535 3761600..3762004 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3762004 yqjE 7154535 yqjE Escherichia coli IAI39 hypothetical protein YP_002409503.1 3761600 D 585057 CDS YP_002409504.1 218701875 7154536 3761994..3762293 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3762293 yqjK 7154536 yqjK Escherichia coli IAI39 hypothetical protein YP_002409504.1 3761994 D 585057 CDS YP_002409505.1 218701876 7154541 3762479..3762871 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative quinol oxidase subunit 3762871 yqjF 7154541 yqjF Escherichia coli IAI39 putative quinol oxidase subunit YP_002409505.1 3762479 D 585057 CDS YP_002409506.1 218701877 7154537 3762941..3763927 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8478329; Product type e : enzyme; S-transferase 3763927 yqjG 7154537 yqjG Escherichia coli IAI39 S-transferase YP_002409506.1 3762941 D 585057 CDS YP_002409507.1 218701878 7154538 3764220..3764585 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3764585 yhaH 7154538 yhaH Escherichia coli IAI39 hypothetical protein YP_002409507.1 3764220 D 585057 CDS YP_002409508.1 218701879 7154041 3764827..3765183 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3765183 yhaI 7154041 yhaI Escherichia coli IAI39 hypothetical protein YP_002409508.1 3764827 D 585057 CDS YP_002409509.1 218701880 7154042 complement(3765234..3766130) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3766130 yhaJ 7154042 yhaJ Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002409509.1 3765234 R 585057 CDS YP_002409510.1 218701881 7154043 3766235..3766936 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative pirin-related protein 3766936 yhaK 7154043 yhaK Escherichia coli IAI39 putative pirin-related protein YP_002409510.1 3766235 D 585057 CDS YP_002409511.1 218701882 7154044 3766959..3767123 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3767123 yhaL 7154044 yhaL Escherichia coli IAI39 hypothetical protein YP_002409511.1 3766959 D 585057 CDS YP_002409512.1 218701883 7154045 complement(3767182..3767904) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 3767904 7154045 ECIAI39_3609 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002409512.1 3767182 R 585057 CDS YP_002409513.1 218701884 7150206 complement(3768009..3768539) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 3768539 7150206 ECIAI39_3610 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002409513.1 3768009 R 585057 CDS YP_002409514.1 218701885 7150207 complement(3768692..3770002) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3770002 yhaM 7150207 yhaM Escherichia coli IAI39 hypothetical protein YP_002409514.1 3768692 R 585057 CDS YP_002409515.1 218701886 7154046 complement(3770030..3771298) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3771298 yhaO 7154046 yhaO Escherichia coli IAI39 putative transporter YP_002409515.1 3770030 R 585057 CDS YP_002409516.1 218701887 7154047 complement(3771636..3773000) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98143432, 9484901; Product type e : enzyme; L-serine dehydratase 3 3773000 tdcG 7154047 tdcG Escherichia coli IAI39 L-serine dehydratase 3 YP_002409516.1 3771636 R 585057 CDS YP_002409517.1 218701888 7152959 complement(3773072..3773461) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12777779, 9484901; Product type e : enzyme; hypothetical protein 3773461 tdcF 7152959 tdcF Escherichia coli IAI39 hypothetical protein YP_002409517.1 3773072 R 585057 CDS YP_002409518.1 218701889 7152958 complement(3773475..3775769) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98143432, 9484901; Product type e : enzyme; pyruvate formate-lyase 4/2-ketobutyrate formate-lyase 3775769 tdcE 7152958 tdcE Escherichia coli IAI39 pyruvate formate-lyase 4/2-ketobutyrate formate-lyase YP_002409518.1 3773475 R 585057 CDS YP_002409519.1 218701890 7152957 complement(3775803..3777023) 1 NC_011750.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase 3777023 tdcD 7152957 tdcD Escherichia coli IAI39 propionate/acetate kinase YP_002409519.1 3775803 R 585057 CDS YP_002409520.1 218701891 7152956 complement(3777037..3778368) 1 NC_011750.1 involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC 3778368 tdcC 7152956 tdcC Escherichia coli IAI39 threonine/serine transporter TdcC YP_002409520.1 3777037 R 585057 CDS YP_002409521.1 218701892 7152955 complement(3778390..3779379) 1 NC_011750.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase 3779379 tdcB 7152955 tdcB Escherichia coli IAI39 threonine dehydratase YP_002409521.1 3778390 R 585057 CDS YP_002409522.1 218701893 7152954 complement(3779478..3780416) 1 NC_011750.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA 3780416 tdcA 7152954 tdcA Escherichia coli IAI39 DNA-binding transcriptional activator TdcA YP_002409522.1 3779478 R 585057 CDS YP_002409523.1 218701894 7152953 3780593..3780949 1 NC_011750.1 participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 3780949 tdcR 7152953 tdcR Escherichia coli IAI39 DNA-binding transcriptional activator TdcR YP_002409523.1 3780593 D 585057 CDS YP_002409524.1 218701895 7152960 3781205..3781744 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3781744 yhaB 7152960 yhaB Escherichia coli IAI39 hypothetical protein YP_002409524.1 3781205 D 585057 CDS YP_002409525.1 218701896 7154039 3781766..3782953 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1705543, 2573820, 2660107, 6351058; hypothetical protein 3782953 yhaC 7154039 yhaC Escherichia coli IAI39 hypothetical protein YP_002409525.1 3781766 D 585057 CDS YP_002409526.1 218701897 7150546 complement(3783469..3784695) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20225875, 69151449, 9772162; Product type e : enzyme; glycerate kinase I 3784695 garK 7150546 garK Escherichia coli IAI39 glycerate kinase I YP_002409526.1 3783469 R 585057 CDS YP_002409527.1 218701898 7151482 complement(3784711..3785601) 1 NC_011750.1 catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase 3785601 garR 7151482 garR Escherichia coli IAI39 tartronate semialdehyde reductase YP_002409527.1 3784711 R 585057 CDS YP_002409528.1 218701899 7151485 complement(3785631..3786401) 1 NC_011750.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase 3786401 garL 7151485 garL Escherichia coli IAI39 alpha-dehydro-beta-deoxy-D-glucarate aldolase YP_002409528.1 3785631 R 585057 CDS YP_002409529.1 218701900 7151483 complement(3786417..3787751) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10762278, 9772162; Product type pt : putative transporter; putative (D)-galactarate transporter 3787751 garP 7151483 garP Escherichia coli IAI39 putative (D)-galactarate transporter YP_002409529.1 3786417 R 585057 CDS YP_002409530.1 218701901 7151484 3788126..3789697 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20225875, 66096392, 81027430, 9772162, 10762278, 2407727; Product type e : enzyme; (D)-galactarate dehydrogenase 3789697 garD 7151484 garD Escherichia coli IAI39 (D)-galactarate dehydrogenase YP_002409530.1 3788126 D 585057 CDS YP_002409531.1 218701902 7151481 3789846..3790181 1 NC_011750.1 SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation; putative regulator PrlF 3790181 sohA 7151481 sohA Escherichia coli IAI39 putative regulator PrlF YP_002409531.1 3789846 D 585057 CDS YP_002409532.1 218701903 7152873 3790181..3790645 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3790645 yhaV 7152873 yhaV Escherichia coli IAI39 hypothetical protein YP_002409532.1 3790181 D 585057 CDS YP_002409533.1 218701904 7154048 complement(3790700..3791509) 1 NC_011750.1 transcriptional repressor for the agaZVWA and agaSYBCDI operons; DNA-binding transcriptional regulator AgaR 3791509 agaR 7154048 agaR Escherichia coli IAI39 DNA-binding transcriptional regulator AgaR YP_002409533.1 3790700 R 585057 CDS YP_002409534.1 218701905 7150702 3791758..3793038 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976750, 20392444, 10931310, 8932697; Product type e : enzyme; tagatose 6-phosphate aldolase 1, kbaZ subunit 3793038 kbaZ 7150702 kbaZ Escherichia coli IAI39 tagatose 6-phosphate aldolase 1, kbaZ subunit YP_002409534.1 3791758 D 585057 CDS YP_002409535.1 218701906 7151874 3793061..3793534 1 NC_011750.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3793534 agaV 7151874 agaV Escherichia coli IAI39 PTS system N-acetylgalactosamine-specific transporter subunit IIB YP_002409535.1 3793061 D 585057 CDS YP_002409536.1 218701907 7150704 3793545..3794324 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative enzyme IIC component of PTS 3794324 7150704 ECIAI39_3633 Escherichia coli IAI39 putative enzyme IIC component of PTS YP_002409536.1 3793545 D 585057 CDS YP_002409537.1 218701908 7150208 3794308..3795192 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative hexose/hexosamine family PTS permease IID component 3795192 7150208 ECIAI39_3634 Escherichia coli IAI39 putative hexose/hexosamine family PTS permease IID component YP_002409537.1 3794308 D 585057 CDS YP_002409538.1 218701909 7150209 3795210..3795644 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system enzyme subunit (N-acetyl-galactosamine / galactosamine PTS system enzyme IIA component) 3795644 7150209 ECIAI39_3635 Escherichia coli IAI39 putative phosphotransferase system enzyme subunit (N-acetyl-galactosamine / galactosamine PTS system enzyme IIA component) YP_002409538.1 3795210 D 585057 CDS YP_002409539.1 218701910 7150210 3795620..3796774 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; N-acetylglucosamine-6-phosphate deacetylase 3796774 agaA 7150210 agaA Escherichia coli IAI39 N-acetylglucosamine-6-phosphate deacetylase YP_002409539.1 3795620 D 585057 CDS YP_002409540.1 218701911 7150697 3797125..3798279 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689210, 9697096, 14731281, 8932697; Product type e : enzyme; tagatose-6-phosphate ketose/aldose isomerase 3798279 agaS 7150697 agaS Escherichia coli IAI39 tagatose-6-phosphate ketose/aldose isomerase YP_002409540.1 3797125 D 585057 CDS YP_002409541.1 218701912 7150703 3798292..3799152 1 NC_011750.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 3799152 kbaY 7150703 kbaY Escherichia coli IAI39 tagatose-bisphosphate aldolase YP_002409541.1 3798292 D 585057 CDS YP_002409542.1 218701913 7151873 3799319..3799795 1 NC_011750.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3799795 agaB 7151873 agaB Escherichia coli IAI39 PTS system N-acetylgalactosamine-specific transporter subunit IIB YP_002409542.1 3799319 D 585057 CDS YP_002409543.1 218701914 7150698 3799834..3800637 1 NC_011750.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIC 3800637 agaC 7150698 agaC Escherichia coli IAI39 PTS system N-acetylgalactosamine-specific transporter subunit IIC YP_002409543.1 3799834 D 585057 CDS YP_002409544.1 218701915 7150699 3800627..3801418 1 NC_011750.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IID 3801418 agaD 7150699 agaD Escherichia coli IAI39 PTS system N-acetylgalactosamine-specific transporter subunit IID YP_002409544.1 3800627 D 585057 CDS YP_002409545.1 218701916 7150700 3801419..3802186 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10931310; Product type e : enzyme; galactosamine-6-phosphate isomerase 3802186 agaI 7150700 agaI Escherichia coli IAI39 galactosamine-6-phosphate isomerase YP_002409545.1 3801419 D 585057 CDS YP_002409546.1 218701917 7150701 complement(3802236..3803099) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase 3803099 yraL 7150701 yraL Escherichia coli IAI39 putative methyltransferase YP_002409546.1 3802236 R 585057 CDS YP_002409547.1 218701918 7154542 3803164..3805200 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3805200 yraM 7154542 yraM Escherichia coli IAI39 hypothetical protein YP_002409547.1 3803164 D 585057 CDS YP_002409548.1 218701919 7154543 3805158..3805553 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3805553 yraN 7154543 yraN Escherichia coli IAI39 hypothetical protein YP_002409548.1 3805158 D 585057 CDS YP_002409549.1 218701920 7154544 3805573..3806163 1 NC_011750.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; DnaA initiator-associating protein DiaA 3806163 yraO 7154544 yraO Escherichia coli IAI39 DnaA initiator-associating protein DiaA YP_002409549.1 3805573 D 585057 CDS YP_002409550.1 218701921 7154545 3806173..3806748 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3806748 ecfH 7154545 ecfH Escherichia coli IAI39 hypothetical protein YP_002409550.1 3806173 D 585057 CDS YP_002409551.1 218701922 7151198 complement(3806861..3807901) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease 3807901 yraQ 7151198 yraQ Escherichia coli IAI39 putative permease YP_002409551.1 3806861 R 585057 CDS YP_002409552.1 218701923 7154546 complement(3807974..3808609) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleoside-diphosphate-sugar epimerase 3808609 yraR 7154546 yraR Escherichia coli IAI39 putative nucleoside-diphosphate-sugar epimerase YP_002409552.1 3807974 R 585057 CDS YP_002409553.1 218701924 7154547 3808737..3809255 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative intracellular protease 3809255 yhbO 7154547 yhbO Escherichia coli IAI39 putative intracellular protease YP_002409553.1 3808737 D 585057 CDS YP_002409554.1 218701925 7154053 complement(3809235..3809678) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3809678 yhbP 7154053 yhbP Escherichia coli IAI39 hypothetical protein YP_002409554.1 3809235 R 585057 CDS YP_002409555.1 218701926 7154054 3809729..3810031 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; GIY-YIG nuclease superfamily protein 3810031 yhbQ 7154054 yhbQ Escherichia coli IAI39 GIY-YIG nuclease superfamily protein YP_002409555.1 3809729 D 585057 CDS YP_002409556.1 218701927 7154055 complement(3810018..3810521) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA N-acyltransferase domain-containing acyltransferase 3810521 yhbS 7154055 yhbS Escherichia coli IAI39 putative acyl-CoA N-acyltransferase domain-containing acyltransferase YP_002409556.1 3810018 R 585057 CDS YP_002409557.1 218701928 7154056 complement(3810515..3811039) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative lipid carrier protein 3811039 yhbT 7154056 yhbT Escherichia coli IAI39 putative lipid carrier protein YP_002409557.1 3810515 R 585057 CDS YP_002409558.1 218701929 7154057 3811248..3812243 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10206698; Product type e : enzyme; collagenase-like peptidase 3812243 yhbU 7154057 yhbU Escherichia coli IAI39 collagenase-like peptidase YP_002409558.1 3811248 D 585057 CDS YP_002409559.1 218701930 7154058 3812252..3813130 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10206698; Product type e : enzyme; protease 3813130 yhbV 7154058 yhbV Escherichia coli IAI39 protease YP_002409559.1 3812252 D 585057 CDS YP_002409560.1 218701931 7154059 3813211..3814218 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3814218 yhbW 7154059 yhbW Escherichia coli IAI39 hypothetical protein YP_002409560.1 3813211 D 585057 CDS YP_002409561.1 218701932 7154060 complement(3814337..3815581) 1 NC_011750.1 tryptophan transporter of high affinity; tryptophan permease 3815581 mtr 7154060 mtr Escherichia coli IAI39 tryptophan permease YP_002409561.1 3814337 R 585057 CDS YP_002409562.1 218701933 7152141 complement(3815735..3817624) 1 NC_011750.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD 3817624 deaD 7152141 deaD Escherichia coli IAI39 ATP-dependent RNA helicase DeaD YP_002409562.1 3815735 R 585057 CDS YP_002409563.1 218701934 7151110 complement(3817804..3818688) 1 NC_011750.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI 3818688 nlpI 7151110 nlpI Escherichia coli IAI39 lipoprotein NlpI YP_002409563.1 3817804 R 585057 CDS YP_002409564.1 218701935 7152238 complement(3818797..3821001) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87083499, 91198209, 99234021, 99340204, 2432069, 3005122, 6382163, 9008164, 9298646; Product type e : enzyme; polynucleotide phosphorylase/polyadenylase 3821001 pnp 7152238 pnp Escherichia coli IAI39 polynucleotide phosphorylase/polyadenylase YP_002409564.1 3818797 R 585057 CDS YP_002409565.1 218701936 7152895 complement(3821179..3821448) 1 NC_011750.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 3821448 rpsO 7152895 rpsO Escherichia coli IAI39 30S ribosomal protein S15 YP_002409565.1 3821179 R 585057 CDS YP_002409566.1 218701937 7152727 complement(3821597..3822541) 1 NC_011750.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 3822541 truB 7152727 truB Escherichia coli IAI39 tRNA pseudouridine synthase B YP_002409566.1 3821597 R 585057 CDS YP_002409567.1 218701938 7153040 complement(3822541..3822942) 1 NC_011750.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 3822942 rbfA 7153040 rbfA Escherichia coli IAI39 ribosome-binding factor A YP_002409567.1 3822541 R 585057 CDS YP_002409568.1 218701939 7152569 complement(3823106..3825778) 1 NC_011750.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 3825778 infB 7152569 infB Escherichia coli IAI39 translation initiation factor IF-2 YP_002409568.1 3823106 R 585057 CDS YP_002409569.1 218701940 7151778 complement(3825803..3827290) 1 NC_011750.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 3827290 nusA 7151778 nusA Escherichia coli IAI39 transcription elongation factor NusA YP_002409569.1 3825803 R 585057 CDS YP_002409570.1 218701941 7152284 complement(3827318..3827770) 1 NC_011750.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 3827770 yhbC 7152284 yhbC Escherichia coli IAI39 hypothetical protein YP_002409570.1 3827318 R 585057 CDS YP_002409571.1 218701942 7150594 3828401..3829744 1 NC_011750.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 3829744 argG 7150594 argG Escherichia coli IAI39 argininosuccinate synthase YP_002409571.1 3828401 D 585057 CDS YP_002409572.1 218701943 7150765 complement(3829752..3831377) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase, inner membrane 3831377 yhbX 7150765 yhbX Escherichia coli IAI39 putative hydrolase, inner membrane YP_002409572.1 3829752 R 585057 CDS YP_002409573.1 218701944 7150593 complement(3831937..3832269) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20194819, 21125563, 9020118, 94074540, 9564033, 9644254, 9829959, 99298179, 7556084, 8034620, 8045257, 8244950, 8253068; Product type t : transporter; preprotein translocase subunit SecG 3832269 secG 7150593 secG Escherichia coli IAI39 preprotein translocase subunit SecG YP_002409573.1 3831937 R 585057 CDS YP_002409574.1 218701945 7152823 complement(3832497..3833834) 1 NC_011750.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 3833834 glmM 7152823 glmM Escherichia coli IAI39 phosphoglucosamine mutase YP_002409574.1 3832497 R 585057 CDS YP_002409575.1 218701946 7151520 complement(3833827..3834675) 1 NC_011750.1 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase 3834675 folP 7151520 folP Escherichia coli IAI39 dihydropteroate synthase YP_002409575.1 3833827 R 585057 CDS YP_002409576.1 218701947 7151404 complement(3834765..3836699) 1 NC_011750.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease 3836699 hflB 7151404 hflB Escherichia coli IAI39 ATP-dependent metalloprotease YP_002409576.1 3834765 R 585057 CDS YP_002409577.1 218701948 7151436 complement(3836799..3837428) 1 NC_011750.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase J 3837428 rrmJ 7151436 rrmJ Escherichia coli IAI39 23S rRNA methyltransferase J YP_002409577.1 3836799 R 585057 CDS YP_002409578.1 218701949 7152736 3837554..3837847 1 NC_011750.1 RNA binding protein found associated to pre-50S subunit of the ribosome; putative role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 3837847 yhbY 7152736 yhbY Escherichia coli IAI39 RNA-binding protein YhbY YP_002409578.1 3837554 D 585057 CDS YP_002409579.1 218701950 7154062 complement(3838003..3838479) 1 NC_011750.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 3838479 greA 7154062 greA Escherichia coli IAI39 transcription elongation factor GreA YP_002409579.1 3838003 R 585057 CDS YP_002409580.1 218701951 7151583 3838727..3840160 1 NC_011750.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase/endopeptidase 3840160 dacB 7151583 dacB Escherichia coli IAI39 D-alanyl-D-alanine carboxypeptidase/endopeptidase YP_002409580.1 3838727 D 585057 CDS YP_002409581.1 218701952 7151077 complement(3840201..3841373) 1 NC_011750.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 3841373 obgE 7151077 obgE Escherichia coli IAI39 GTPase ObgE YP_002409581.1 3840201 R 585057 CDS YP_002409582.1 218701953 7152288 complement(3841389..3842354) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3842354 yhbE 7152288 yhbE Escherichia coli IAI39 hypothetical protein YP_002409582.1 3841389 R 585057 CDS YP_002409583.1 218701954 7154050 complement(3842481..3842738) 1 NC_011750.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 3842738 rpmA 7154050 rpmA Escherichia coli IAI39 50S ribosomal protein L27 YP_002409583.1 3842481 R 585057 CDS YP_002409584.1 218701955 7152694 complement(3842759..3843070) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91088242, 94146411, 10094780, 387076, 8312607; Product type s : structure; 50S ribosomal protein L21 3843070 rplU 7152694 rplU Escherichia coli IAI39 50S ribosomal protein L21 YP_002409584.1 3842759 R 585057 CDS YP_002409585.1 218701956 7152689 3843329..3844300 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94311902, 97284515, 2670911, 8037730, 8312607; Product type e : enzyme; octaprenyl diphosphate synthase 3844300 ispB 7152689 ispB Escherichia coli IAI39 octaprenyl diphosphate synthase YP_002409585.1 3843329 D 585057 CDS YP_002409586.1 218701957 7151852 3844528..3844806 1 NC_011750.1 activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 3844806 sfsB 7151852 sfsB Escherichia coli IAI39 DNA-binding transcriptional regulator Nlp YP_002409586.1 3844528 D 585057 CDS YP_002409587.1 218701958 7152843 complement(3844854..3846113) 1 NC_011750.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 3846113 murA 7152843 murA Escherichia coli IAI39 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_002409587.1 3844854 R 585057 CDS YP_002409588.1 218701959 7152145 complement(3846168..3846422) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3846422 yrbA 7152145 yrbA Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002409588.1 3846168 R 585057 CDS YP_002409589.1 218701960 7154548 complement(3846582..3846875) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3846875 yrbB 7154548 yrbB Escherichia coli IAI39 hypothetical protein YP_002409589.1 3846582 R 585057 CDS YP_002409590.1 218701961 7154549 complement(3846875..3847510) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene ABC transporter membrane protein 3847510 yrbC 7154549 yrbC Escherichia coli IAI39 toluene ABC transporter membrane protein YP_002409590.1 3846875 R 585057 CDS YP_002409591.1 218701962 7154550 complement(3847529..3848080) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene ABC transporter membrane protein 3848080 yrbD 7154550 yrbD Escherichia coli IAI39 toluene ABC transporter membrane protein YP_002409591.1 3847529 R 585057 CDS YP_002409592.1 218701963 7154551 complement(3848085..3848867) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene ABC transporter membrane protein 3848867 yrbE 7154551 yrbE Escherichia coli IAI39 toluene ABC transporter membrane protein YP_002409592.1 3848085 R 585057 CDS YP_002409593.1 218701964 7154552 complement(3848875..3849684) 1 NC_011750.1 ATP-binding subunit of a putative ABC toluene efflux transporter; putative ABC transporter ATP-binding protein YrbF 3849684 yrbF 7154552 yrbF Escherichia coli IAI39 putative ABC transporter ATP-binding protein YrbF YP_002409593.1 3848875 R 585057 CDS YP_002409594.1 218701965 7154553 3849894..3850871 1 NC_011750.1 YrbG; inner membrane protein involved in cell envelope integrity; putative sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; putative calcium/sodium:proton antiporter 3850871 yrbG 7154553 yrbG Escherichia coli IAI39 putative calcium/sodium:proton antiporter YP_002409594.1 3849894 D 585057 CDS YP_002409595.1 218701966 7154554 3850885..3851871 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12805358; Product type e : enzyme; D-arabinose 5-phosphate isomerase 3851871 kdsD 7154554 kdsD Escherichia coli IAI39 D-arabinose 5-phosphate isomerase YP_002409595.1 3850885 D 585057 CDS YP_002409596.1 218701967 7151888 3851892..3852458 1 NC_011750.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 3852458 kdsC 7151888 kdsC Escherichia coli IAI39 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase YP_002409596.1 3851892 D 585057 CDS YP_002409597.1 218701968 7151887 3852455..3853030 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3853030 yrbK 7151887 yrbK Escherichia coli IAI39 hypothetical protein YP_002409597.1 3852455 D 585057 CDS YP_002409598.1 218701969 7154555 3852999..3853556 1 NC_011750.1 LptA; periplasmic binding protein part of a putative ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 3853556 lptA 7154555 lptA Escherichia coli IAI39 lipopolysaccharide transport periplasmic protein LptA YP_002409598.1 3852999 D 585057 CDS YP_002409599.1 218701970 7151963 3853563..3854288 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7876255, 9298646, 17056748; Product type pt : putative transporter; putative ABC transporter ATP-binding protein YhbG 3854288 lptB 7151963 lptB Escherichia coli IAI39 putative ABC transporter ATP-binding protein YhbG YP_002409599.1 3853563 D 585057 CDS YP_002409600.1 218701971 7151964 3854336..3855769 1 NC_011750.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 3855769 rpoN 7151964 rpoN Escherichia coli IAI39 RNA polymerase factor sigma-54 YP_002409600.1 3854336 D 585057 CDS YP_002409601.1 218701972 7152709 3855792..3856079 1 NC_011750.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; putative sigma(54) modulation protein 3856079 yhbH 7152709 yhbH Escherichia coli IAI39 putative sigma(54) modulation protein YP_002409601.1 3855792 D 585057 CDS YP_002409602.1 218701973 7154051 3856197..3856688 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88212176, 90136533, 90274974, 95020584, 95181483, 7876255, 8025669, 8444818, 9636714; Product type t : transporter; PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN 3856688 ptsN 7154051 ptsN Escherichia coli IAI39 PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN YP_002409602.1 3856197 D 585057 CDS YP_002409603.1 218701974 7152521 3856734..3857588 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3857588 yhbJ 7152521 yhbJ Escherichia coli IAI39 hypothetical protein YP_002409603.1 3856734 D 585057 CDS YP_002409604.1 218701975 7154052 3857585..3857857 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10473571, 95181483, 7876255, 8025669; Product type t : transporter; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 3857857 npr 7154052 npr Escherichia coli IAI39 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) YP_002409604.1 3857585 D 585057 CDS YP_002409605.1 218701976 7152243 3858070..3858702 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 89083480; hypothetical protein 3858702 yrbL 7152243 yrbL Escherichia coli IAI39 hypothetical protein YP_002409605.1 3858070 D 585057 CDS YP_002409606.1 218701977 7154556 complement(3858699..3859427) 1 NC_011750.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase 3859427 mtgA 7154556 mtgA Escherichia coli IAI39 monofunctional biosynthetic peptidoglycan transglycosylase YP_002409606.1 3858699 R 585057 CDS YP_002409607.1 218701978 7152137 complement(3859424..3860077) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92246944, 98269038, 1575737, 9603997; Product type pe : putative enzyme; isoprenoid biosynthesis protein 3860077 elbB 7152137 elbB Escherichia coli IAI39 isoprenoid biosynthesis protein YP_002409607.1 3859424 R 585057 CDS YP_002409608.1 218701979 7152791 complement(3860307..3862643) 1 NC_011750.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB 3862643 arcB 7152791 arcB Escherichia coli IAI39 aerobic respiration control sensor protein ArcB YP_002409608.1 3860307 R 585057 CDS YP_002409609.1 218701980 7150757 complement(3862739..3863668) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Fe-S oxidoreductase 3863668 yhcC 7150757 yhcC Escherichia coli IAI39 putative Fe-S oxidoreductase YP_002409609.1 3862739 R 585057 CDS YP_002409610.1 218701981 7154064 3864250..3868803 1 NC_011750.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase subunit alpha 3868803 gltB 7154064 gltB Escherichia coli IAI39 glutamate synthase subunit alpha YP_002409610.1 3864250 D 585057 CDS YP_002409611.1 218701982 7151549 3868816..3870234 1 NC_011750.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 3870234 gltD 7151549 gltD Escherichia coli IAI39 glutamate synthase subunit beta YP_002409611.1 3868816 D 585057 CDS YP_002409612.1 218701983 7151550 3870403..3871530 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3871530 yhcG 7151550 yhcG Escherichia coli IAI39 hypothetical protein YP_002409612.1 3870403 D 585057 CDS YP_002409613.1 218701984 7154065 complement(3871590..3872054) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3872054 yhcH 7154065 yhcH Escherichia coli IAI39 hypothetical protein YP_002409613.1 3871590 R 585057 CDS YP_002409614.1 218701985 7154066 complement(3872051..3872926) 1 NC_011750.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 3872926 nanK 7154066 nanK Escherichia coli IAI39 N-acetylmannosamine kinase YP_002409614.1 3872051 R 585057 CDS YP_002409615.1 218701986 7152179 complement(3872923..3873612) 1 NC_011750.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 3873612 nanE 7152179 nanE Escherichia coli IAI39 N-acetylmannosamine-6-phosphate 2-epimerase YP_002409615.1 3872923 R 585057 CDS YP_002409616.1 218701987 7152178 complement(3873660..3875150) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96011396, 9864311, 7592358; Product type t : transporter; putative sialic acid transporter 3875150 nanT 7152178 nanT Escherichia coli IAI39 putative sialic acid transporter YP_002409616.1 3873660 R 585057 CDS YP_002409617.1 218701988 7152181 complement(3875259..3876152) 1 NC_011750.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 3876152 nanA 7152181 nanA Escherichia coli IAI39 N-acetylneuraminate lyase YP_002409617.1 3875259 R 585057 CDS YP_002409618.1 218701989 7152177 complement(3876274..3877065) 1 NC_011750.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR 3877065 nanR 7152177 nanR Escherichia coli IAI39 transcriptional regulator NanR YP_002409618.1 3876274 R 585057 CDS YP_002409619.1 218701990 7152180 3877445..3878812 1 NC_011750.1 YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic; putative cryptic C4-dicarboxylate transporter DcuD 3878812 dcuD 7152180 dcuD Escherichia coli IAI39 putative cryptic C4-dicarboxylate transporter DcuD YP_002409619.1 3877445 D 585057 CDS YP_002409620.1 218701991 7151098 complement(3878856..3879353) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12445774, 94293773, 1721886, 3029697, 8022275; Product type f : factor; ClpXP protease specificity-enhancing factor 3879353 sspB 7151098 sspB Escherichia coli IAI39 ClpXP protease specificity-enhancing factor YP_002409620.1 3878856 R 585057 CDS YP_002409621.1 218701992 7152907 complement(3879359..3879997) 1 NC_011750.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A 3879997 sspA 7152907 sspA Escherichia coli IAI39 stringent starvation protein A YP_002409621.1 3879359 R 585057 CDS YP_002409622.1 218701993 7152906 complement(3880267..3881061) 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3881061 7152906 ECIAI39_3719 Escherichia coli IAI39 hypothetical protein YP_002409622.1 3880267 R 585057 CDS YP_002409623.1 218701994 7150211 complement(3881216..3881608) 1 NC_011750.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 3881608 rpsI 7150211 rpsI Escherichia coli IAI39 30S ribosomal protein S9 YP_002409623.1 3881216 R 585057 CDS YP_002409624.1 218701995 7152721 complement(3881624..3882052) 1 NC_011750.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 3882052 rplM 7152721 rplM Escherichia coli IAI39 50S ribosomal protein L13 YP_002409624.1 3881624 R 585057 CDS YP_002409625.1 218701996 7152681 complement(3882271..3883398) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3883398 yhcM 7152681 yhcM Escherichia coli IAI39 hypothetical protein YP_002409625.1 3882271 R 585057 CDS YP_002409626.1 218701997 7154067 3883592..3883990 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16079137; Product type pe : putative enzyme; cytochrome d ubiquinol oxidase subunit III 3883990 yhcB 7154067 yhcB Escherichia coli IAI39 cytochrome d ubiquinol oxidase subunit III YP_002409626.1 3883592 D 585057 CDS YP_002409627.1 218701998 7154063 3884144..3885511 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8830688, 96165272, 8576051, 8576052, 9740056; Product type e : enzyme; serine endoprotease 3885511 degQ 7154063 degQ Escherichia coli IAI39 serine endoprotease YP_002409627.1 3884144 D 585057 CDS YP_002409628.1 218701999 7151115 3885601..3886668 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15137941, 15225661, 21352996, 96165272, 99431977, 3322223, 8576051; Product type e : enzyme; serine endoprotease 3886668 degS 7151115 degS Escherichia coli IAI39 serine endoprotease YP_002409628.1 3885601 D 585057 CDS YP_002409629.1 218702000 7151116 3886772..3888118 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element 3888118 insG 7151116 insG Escherichia coli IAI39 putative IS4 transposase; KpLE2 phage-like element YP_002409629.1 3886772 D 585057 CDS YP_002409630.1 218702001 7151816 complement(3888169..3889107) 1 NC_011750.1 oxidizes malate to oxaloacetate; malate dehydrogenase 3889107 mdh 7151816 mdh Escherichia coli IAI39 malate dehydrogenase YP_002409630.1 3888169 R 585057 CDS YP_002409631.1 218702002 7152021 3889542..3890012 1 NC_011750.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 3890012 argR 7152021 argR Escherichia coli IAI39 arginine repressor YP_002409631.1 3889542 D 585057 CDS YP_002409632.1 218702003 7150771 3890376..3890639 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3890639 yhcN 7150771 yhcN Escherichia coli IAI39 hypothetical protein YP_002409632.1 3890376 D 585057 CDS YP_002409633.1 218702004 7154068 complement(3890696..3890968) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative barnase inhibitor 3890968 yhcO 7154068 yhcO Escherichia coli IAI39 putative barnase inhibitor YP_002409633.1 3890696 R 585057 CDS YP_002409634.1 218702005 7154069 complement(3891060..3893027) 1 NC_011750.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB 3893027 aaeB 7154069 aaeB Escherichia coli IAI39 p-hydroxybenzoic acid efflux subunit AaeB YP_002409634.1 3891060 R 585057 CDS YP_002409635.1 218702006 7150641 complement(3893033..3893965) 1 NC_011750.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA 3893965 aaeA 7150641 aaeA Escherichia coli IAI39 p-hydroxybenzoic acid efflux subunit AaeA YP_002409635.1 3893033 R 585057 CDS YP_002409636.1 218702007 7150640 complement(3893973..3894176) 1 NC_011750.1 membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein 3894176 aaeX 7150640 aaeX Escherichia coli IAI39 hypothetical protein YP_002409636.1 3893973 R 585057 CDS YP_002409637.1 218702008 7150643 3894359..3895288 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15489430; Product type r : regulator; putative DNA-binding transcriptional regulator 3895288 aaeR 7150643 aaeR Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002409637.1 3894359 D 585057 CDS YP_002409638.1 218702009 7150642 complement(3895416..3896861) 1 NC_011750.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD 3896861 tldD 7150642 tldD Escherichia coli IAI39 protease TldD YP_002409638.1 3895416 R 585057 CDS YP_002409639.1 218702010 7152991 complement(3896959..3897681) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 3897681 7152991 ECIAI39_3736 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002409639.1 3896959 R 585057 CDS YP_002409640.1 218702011 7150212 complement(3897786..3898316) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 3898316 7150212 ECIAI39_3737 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002409640.1 3897786 R 585057 CDS YP_002409641.1 218702012 7150213 complement(3898452..3902252) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10960106; Product type pm : putative membrane component; hypothetical protein 3902252 yhdP 7150213 yhdP Escherichia coli IAI39 hypothetical protein YP_002409641.1 3898452 R 585057 CDS YP_002409642.1 218702013 7154075 complement(3902320..3903789) 1 NC_011750.1 involved in the processing of the 5'end of 16S rRNA; ribonuclease G 3903789 rng 7154075 rng Escherichia coli IAI39 ribonuclease G YP_002409642.1 3902320 R 585057 CDS YP_002409643.1 218702014 7152657 complement(3903779..3904372) 1 NC_011750.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 3904372 yhdE 7152657 yhdE Escherichia coli IAI39 Maf-like protein YP_002409643.1 3903779 R 585057 CDS YP_002409644.1 218702015 7154070 complement(3904381..3904869) 1 NC_011750.1 part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD 3904869 mreD 7154070 mreD Escherichia coli IAI39 rod shape-determining protein MreD YP_002409644.1 3904381 R 585057 CDS YP_002409645.1 218702016 7152128 complement(3904869..3905972) 1 NC_011750.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 3905972 mreC 7152128 mreC Escherichia coli IAI39 rod shape-determining protein MreC YP_002409645.1 3904869 R 585057 CDS YP_002409646.1 218702017 7152127 complement(3906038..3907081) 1 NC_011750.1 functions in MreBCD complex in some organisms; rod shape-determining protein MreB 3907081 mreB 7152127 mreB Escherichia coli IAI39 rod shape-determining protein MreB YP_002409646.1 3906038 R 585057 CDS YP_002409647.1 218702018 7152126 complement(3907386..3909326) 1 NC_011750.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD 3909326 csrD 7152126 csrD Escherichia coli IAI39 regulatory protein CsrD YP_002409647.1 3907386 R 585057 CDS YP_002409648.1 218702019 7151024 3909478..3910452 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 3910452 yhdH 7151024 yhdH Escherichia coli IAI39 putative oxidoreductase YP_002409648.1 3909478 D 585057 CDS YP_002409649.1 218702020 7154071 3911430..3911900 1 NC_011750.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3911900 accB 7154071 accB Escherichia coli IAI39 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_002409649.1 3911430 D 585057 CDS YP_002409650.1 218702021 7150657 3911911..3913260 1 NC_011750.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 3913260 accC 7150657 accC Escherichia coli IAI39 acetyl-CoA carboxylase biotin carboxylase subunit YP_002409650.1 3911911 D 585057 CDS YP_002409651.1 218702022 7150658 complement(3913352..3914398) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3914398 7150658 ECIAI39_3749 Escherichia coli IAI39 hypothetical protein YP_002409651.1 3913352 R 585057 CDS YP_002409652.1 218702023 7150214 complement(3914395..3915357) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative carbohydrate kinase 3915357 7150214 ECIAI39_3750 Escherichia coli IAI39 putative carbohydrate kinase YP_002409652.1 3914395 R 585057 CDS YP_002409653.1 218702024 7150215 complement(3915379..3916368) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter membrane protein 3916368 7150215 ECIAI39_3751 Escherichia coli IAI39 putative sugar ABC transporter membrane protein YP_002409653.1 3915379 R 585057 CDS YP_002409654.1 218702025 7150216 complement(3916369..3917868) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter ATP-binding protein 3917868 7150216 ECIAI39_3752 Escherichia coli IAI39 putative sugar ABC transporter ATP-binding protein YP_002409654.1 3916369 R 585057 CDS YP_002409655.1 218702026 7150217 complement(3917929..3918825) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC-type sugar transport system, periplasmic component 3918825 7150217 ECIAI39_3753 Escherichia coli IAI39 putative ABC-type sugar transport system, periplasmic component YP_002409655.1 3917929 R 585057 CDS YP_002409656.1 218702027 7150218 complement(3918855..3919709) 1 NC_011750.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 3919709 gatY 7150218 gatY Escherichia coli IAI39 tagatose-bisphosphate aldolase YP_002409656.1 3918855 R 585057 CDS YP_002409657.1 218702028 7150219 3920051..3920881 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DEOR-type transcriptional regulator 3920881 7150219 ECIAI39_3755 Escherichia coli IAI39 putative DEOR-type transcriptional regulator YP_002409657.1 3920051 D 585057 CDS YP_002409658.1 218702029 7150220 3920838..3921848 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative pfkB family carbohydrate kinase 3921848 7150220 ECIAI39_3756 Escherichia coli IAI39 putative pfkB family carbohydrate kinase YP_002409658.1 3920838 D 585057 CDS YP_002409659.1 218702030 7150221 3921942..3922184 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3922184 yhdT 7150221 yhdT Escherichia coli IAI39 hypothetical protein YP_002409659.1 3921942 D 585057 CDS YP_002409660.1 218702031 7154076 3922174..3923625 1 NC_011750.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 3923625 panF 7154076 panF Escherichia coli IAI39 sodium/panthothenate symporter YP_002409660.1 3922174 D 585057 CDS YP_002409661.1 218702032 7152327 3923637..3924518 1 NC_011750.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 3924518 prmA 7152327 prmA Escherichia coli IAI39 ribosomal protein L11 methyltransferase YP_002409661.1 3923637 D 585057 CDS YP_002409662.1 218702033 7152480 3924847..3925812 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566, 1459953, 1547773, 2835774, 2837762, 8226664; Product type e : enzyme; tRNA-dihydrouridine synthase B 3925812 dusB 7152480 dusB Escherichia coli IAI39 tRNA-dihydrouridine synthase B YP_002409662.1 3924847 D 585057 CDS YP_002409663.1 218702034 7151186 3925838..3926134 1 NC_011750.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 3926134 fis 7151186 fis Escherichia coli IAI39 DNA-binding protein Fis YP_002409663.1 3925838 D 585057 CDS YP_002409664.1 218702035 7151338 3926220..3927104 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15028690, 9073062; Product type e : enzyme; putative methyltransferase 3927104 yhdJ 7151338 yhdJ Escherichia coli IAI39 putative methyltransferase YP_002409664.1 3926220 D 585057 CDS YP_002409665.1 218702036 7154072 3927188..3927367 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3927367 yhdU 7154072 yhdU Escherichia coli IAI39 hypothetical protein YP_002409665.1 3927188 D 585057 CDS YP_002409666.1 218702037 7154077 complement(3927370..3928032) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8203018, 11257026, 8407802, 1720861; Product type r : regulator; DNA-binding transcriptional regulator EnvR 3928032 envR 7154077 envR Escherichia coli IAI39 DNA-binding transcriptional regulator EnvR YP_002409666.1 3927370 R 585057 CDS YP_002409667.1 218702038 7151229 3928431..3929588 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012493, 1720861; Product type lp : lipoprotein; cytoplasmic membrane lipoprotein 3929588 acrE 7151229 acrE Escherichia coli IAI39 cytoplasmic membrane lipoprotein YP_002409667.1 3928431 D 585057 CDS YP_002409668.1 218702039 7150678 3932926..3933147 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3933147 yhdV 7150678 yhdV Escherichia coli IAI39 hypothetical protein YP_002409668.1 3932926 D 585057 CDS YP_002409669.1 218702040 7154078 3933686..3934603 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid ABC transporter periplasmic-binding protein 3934603 aapJ 7154078 aapJ Escherichia coli IAI39 amino-acid ABC transporter periplasmic-binding protein YP_002409669.1 3933686 D 585057 CDS YP_002409670.1 218702041 7150644 3934671..3935852 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid ABC transporter membrane protein 3935852 aapQ 7150644 aapQ Escherichia coli IAI39 amino-acid ABC transporter membrane protein YP_002409670.1 3934671 D 585057 CDS YP_002409671.1 218702042 7150647 3935862..3936965 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid ABC transporter membrane protein 3936965 aapM 7150647 aapM Escherichia coli IAI39 amino-acid ABC transporter membrane protein YP_002409671.1 3935862 D 585057 CDS YP_002409672.1 218702043 7150645 3936973..3937731 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8809753, 8898392; Product type t : transporter; amino-acid ABC transporter ATP-binding protein 3937731 aapP 7150645 aapP Escherichia coli IAI39 amino-acid ABC transporter ATP-binding protein YP_002409672.1 3936973 D 585057 CDS YP_002409673.1 218702044 7149774 3943284..3944165 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3944165 yrdA 7149774 yrdA Escherichia coli IAI39 hypothetical protein YP_002409673.1 3943284 D 585057 CDS YP_002409674.1 218702045 7154557 complement(3944395..3945213) 1 NC_011750.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 3945213 aroE 7154557 aroE Escherichia coli IAI39 shikimate 5-dehydrogenase YP_002409674.1 3944395 R 585057 CDS YP_002409675.1 218702046 7150779 complement(3945218..3945790) 1 NC_011750.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; putative ribosome maturation factor 3945790 yrdC 7150779 yrdC Escherichia coli IAI39 putative ribosome maturation factor YP_002409675.1 3945218 R 585057 CDS YP_002409676.1 218702047 7154558 complement(3945795..3946337) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative DNA topoisomerase 3946337 yrdD 7154558 yrdD Escherichia coli IAI39 putative DNA topoisomerase YP_002409676.1 3945795 R 585057 CDS YP_002409677.1 218702048 7154559 complement(3946366..3946839) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8432722; hypothetical protein 3946839 smg 7154559 smg Escherichia coli IAI39 hypothetical protein YP_002409677.1 3946366 R 585057 CDS YP_002409678.1 218702049 7152865 3948065..3948574 1 NC_011750.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 3948574 def 7152865 def Escherichia coli IAI39 peptide deformylase YP_002409678.1 3948065 D 585057 CDS YP_002409679.1 218702050 7151113 3948589..3949536 1 NC_011750.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 3949536 fmt 7151113 fmt Escherichia coli IAI39 methionyl-tRNA formyltransferase YP_002409679.1 3948589 D 585057 CDS YP_002409680.1 218702051 7151393 3949582..3950871 1 NC_011750.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase B 3950871 rsmB 7151393 rsmB Escherichia coli IAI39 16S rRNA methyltransferase B YP_002409680.1 3949582 D 585057 CDS YP_002409681.1 218702052 7152743 3950893..3952269 1 NC_011750.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 3952269 trkA 7152743 trkA Escherichia coli IAI39 potassium transporter peripheral membrane component YP_002409681.1 3950893 D 585057 CDS YP_002409682.1 218702053 7153022 3952399..3952809 1 NC_011750.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 3952809 mscL 7153022 mscL Escherichia coli IAI39 large-conductance mechanosensitive channel YP_002409682.1 3952399 D 585057 CDS YP_002409683.1 218702054 7152132 complement(3952806..3953024) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3953024 yhdL 7152132 yhdL Escherichia coli IAI39 hypothetical protein YP_002409683.1 3952806 R 585057 CDS YP_002409684.1 218702055 7154073 complement(3953080..3953505) 1 NC_011750.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator 3953505 zntR 7154073 zntR Escherichia coli IAI39 zinc-responsive transcriptional regulator YP_002409684.1 3953080 R 585057 CDS YP_002409685.1 218702056 7154591 complement(3953516..3953884) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3953884 yhdN 7154591 yhdN Escherichia coli IAI39 hypothetical protein YP_002409685.1 3953516 R 585057 CDS YP_002409686.1 218702057 7154074 complement(3953991..3954374) 1 NC_011750.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 3954374 rplQ 7154074 rplQ Escherichia coli IAI39 50S ribosomal protein L17 YP_002409686.1 3953991 R 585057 CDS YP_002409687.1 218702058 7152685 complement(3954415..3955404) 1 NC_011750.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 3955404 rpoA 7152685 rpoA Escherichia coli IAI39 DNA-directed RNA polymerase subunit alpha YP_002409687.1 3954415 R 585057 CDS YP_002409688.1 218702059 7152703 complement(3955430..3956050) 1 NC_011750.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 3956050 rpsD 7152703 rpsD Escherichia coli IAI39 30S ribosomal protein S4 YP_002409688.1 3955430 R 585057 CDS YP_002409689.1 218702060 7152716 complement(3956084..3956473) 1 NC_011750.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 3956473 rpsK 7152716 rpsK Escherichia coli IAI39 30S ribosomal protein S11 YP_002409689.1 3956084 R 585057 CDS YP_002409690.1 218702061 7152723 complement(3956490..3956846) 1 NC_011750.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 3956846 rpsM 7152723 rpsM Escherichia coli IAI39 30S ribosomal protein S13 YP_002409690.1 3956490 R 585057 CDS YP_002409691.1 218702062 7150547 complement(3957141..3958472) 1 NC_011750.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 3958472 secY 7150547 secY Escherichia coli IAI39 preprotein translocase subunit SecY YP_002409691.1 3957141 R 585057 CDS YP_002409692.1 218702063 7152825 complement(3958480..3958914) 1 NC_011750.1 late assembly protein; 50S ribosomal protein L15 3958914 rplO 7152825 rplO Escherichia coli IAI39 50S ribosomal protein L15 YP_002409692.1 3958480 R 585057 CDS YP_002409693.1 218702064 7152683 complement(3958918..3959097) 1 NC_011750.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 3959097 rpmD 7152683 rpmD Escherichia coli IAI39 50S ribosomal protein L30 YP_002409693.1 3958918 R 585057 CDS YP_002409694.1 218702065 7152697 complement(3959101..3959604) 1 NC_011750.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 3959604 rpsE 7152697 rpsE Escherichia coli IAI39 30S ribosomal protein S5 YP_002409694.1 3959101 R 585057 CDS YP_002409695.1 218702066 7152717 complement(3959619..3959972) 1 NC_011750.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 3959972 rplR 7152717 rplR Escherichia coli IAI39 50S ribosomal protein L18 YP_002409695.1 3959619 R 585057 CDS YP_002409696.1 218702067 7152686 complement(3959982..3960515) 1 NC_011750.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 3960515 rplF 7152686 rplF Escherichia coli IAI39 50S ribosomal protein L6 YP_002409696.1 3959982 R 585057 CDS YP_002409697.1 218702068 7152676 complement(3960528..3960920) 1 NC_011750.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 3960920 rpsH 7152676 rpsH Escherichia coli IAI39 30S ribosomal protein S8 YP_002409697.1 3960528 R 585057 CDS YP_002409698.1 218702069 7152720 complement(3960954..3961259) 1 NC_011750.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 3961259 rpsN 7152720 rpsN Escherichia coli IAI39 30S ribosomal protein S14 YP_002409698.1 3960954 R 585057 CDS YP_002409699.1 218702070 7152726 complement(3961274..3961813) 1 NC_011750.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 3961813 rplE 7152726 rplE Escherichia coli IAI39 50S ribosomal protein L5 YP_002409699.1 3961274 R 585057 CDS YP_002409700.1 218702071 7152675 complement(3961828..3962142) 1 NC_011750.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 3962142 rplX 7152675 rplX Escherichia coli IAI39 50S ribosomal protein L24 YP_002409700.1 3961828 R 585057 CDS YP_002409701.1 218702072 7152692 complement(3962153..3962524) 1 NC_011750.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 3962524 rplN 7152692 rplN Escherichia coli IAI39 50S ribosomal protein L14 YP_002409701.1 3962153 R 585057 CDS YP_002409702.1 218702073 7152682 complement(3962689..3962943) 1 NC_011750.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 3962943 rpsQ 7152682 rpsQ Escherichia coli IAI39 30S ribosomal protein S17 YP_002409702.1 3962689 R 585057 CDS YP_002409703.1 218702074 7152729 complement(3962943..3963134) 1 NC_011750.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 3963134 rpmC 7152729 rpmC Escherichia coli IAI39 50S ribosomal protein L29 YP_002409703.1 3962943 R 585057 CDS YP_002409704.1 218702075 7152696 complement(3963134..3963544) 1 NC_011750.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 3963544 rplP 7152696 rplP Escherichia coli IAI39 50S ribosomal protein L16 YP_002409704.1 3963134 R 585057 CDS YP_002409705.1 218702076 7152684 complement(3963557..3964258) 1 NC_011750.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 3964258 rpsC 7152684 rpsC Escherichia coli IAI39 30S ribosomal protein S3 YP_002409705.1 3963557 R 585057 CDS YP_002409706.1 218702077 7152715 complement(3964276..3964608) 1 NC_011750.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 3964608 rplV 7152715 rplV Escherichia coli IAI39 50S ribosomal protein L22 YP_002409706.1 3964276 R 585057 CDS YP_002409707.1 218702078 7152690 complement(3964623..3964901) 1 NC_011750.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 3964901 rpsS 7152690 rpsS Escherichia coli IAI39 30S ribosomal protein S19 YP_002409707.1 3964623 R 585057 CDS YP_002409708.1 218702079 7152731 complement(3964918..3965739) 1 NC_011750.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 3965739 rplB 7152731 rplB Escherichia coli IAI39 50S ribosomal protein L2 YP_002409708.1 3964918 R 585057 CDS YP_002409709.1 218702080 7152672 complement(3965757..3966059) 1 NC_011750.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 3966059 rplW 7152672 rplW Escherichia coli IAI39 50S ribosomal protein L23 YP_002409709.1 3965757 R 585057 CDS YP_002409710.1 218702081 7152691 complement(3966056..3966661) 1 NC_011750.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 3966661 rplD 7152691 rplD Escherichia coli IAI39 50S ribosomal protein L4 YP_002409710.1 3966056 R 585057 CDS YP_002409711.1 218702082 7152674 complement(3966672..3967301) 1 NC_011750.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 3967301 rplC 7152674 rplC Escherichia coli IAI39 50S ribosomal protein L3 YP_002409711.1 3966672 R 585057 CDS YP_002409712.1 218702083 7152673 complement(3967334..3967645) 1 NC_011750.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 3967645 rpsJ 7152673 rpsJ Escherichia coli IAI39 30S ribosomal protein S10 YP_002409712.1 3967334 R 585057 CDS YP_002409713.1 218702084 7152722 3968103..3968492 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative bifunctional prepilin peptidase HopD: leader peptidase; methyl transferase (General Secretory Pathway) 3968492 7152722 ECIAI39_3816 Escherichia coli IAI39 putative bifunctional prepilin peptidase HopD: leader peptidase; methyl transferase (General Secretory Pathway) YP_002409713.1 3968103 D 585057 CDS YP_002409714.1 218702085 7150222 complement(3968489..3968965) 1 NC_011750.1 iron storage protein; bacterioferritin 3968965 bfr 7150222 bfr Escherichia coli IAI39 bacterioferritin YP_002409714.1 3968489 R 585057 CDS YP_002409715.1 218702086 7150858 complement(3969038..3969232) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8954950, 9889981, 2661540, 8639572; Product type c : carrier; bacterioferritin-associated ferredoxin 3969232 bfd 7150858 bfd Escherichia coli IAI39 bacterioferritin-associated ferredoxin YP_002409715.1 3969038 R 585057 CDS YP_002409716.1 218702087 7150857 complement(3969415..3970599) 1 NC_011750.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 3970599 tufA 7150857 tufA Escherichia coli IAI39 elongation factor Tu YP_002409716.1 3969415 R 585057 CDS YP_002409717.1 218702088 7153054 complement(3970670..3972784) 1 NC_011750.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 3972784 fusA 7153054 fusA Escherichia coli IAI39 elongation factor G YP_002409717.1 3970670 R 585057 CDS YP_002409718.1 218702089 7151457 complement(3972881..3973351) 1 NC_011750.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 3973351 rpsG 7151457 rpsG Escherichia coli IAI39 30S ribosomal protein S7 YP_002409718.1 3972881 R 585057 CDS YP_002409719.1 218702090 7152719 complement(3973448..3973822) 1 NC_011750.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 3973822 rpsL 7152719 rpsL Escherichia coli IAI39 30S ribosomal protein S12 YP_002409719.1 3973448 R 585057 CDS YP_002409720.1 218702091 7152724 complement(3973948..3974235) 1 NC_011750.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB 3974235 tusB 7152724 tusB Escherichia coli IAI39 sulfur transfer complex subunit TusB YP_002409720.1 3973948 R 585057 CDS YP_002409721.1 218702092 7153058 complement(3974243..3974602) 1 NC_011750.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC 3974602 tusC 7153058 tusC Escherichia coli IAI39 sulfur relay protein TusC YP_002409721.1 3974243 R 585057 CDS YP_002409722.1 218702093 7153059 complement(3974602..3974988) 1 NC_011750.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 3974988 tusD 7153059 tusD Escherichia coli IAI39 sulfur transfer complex subunit TusD YP_002409722.1 3974602 R 585057 CDS YP_002409723.1 218702094 7153060 complement(3974988..3975710) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3975710 yheO 7153060 yheO Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002409723.1 3974988 R 585057 CDS YP_002409724.1 218702095 7154079 complement(3975877..3976689) 1 NC_011750.1 rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase 3976689 fkpA 7154079 fkpA Escherichia coli IAI39 FKBP-type peptidyl-prolyl cis-trans isomerase YP_002409724.1 3975877 R 585057 CDS YP_002409725.1 218702096 7151345 3976910..3977128 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3977128 slyX 7151345 slyX Escherichia coli IAI39 hypothetical protein YP_002409725.1 3976910 D 585057 CDS YP_002409726.1 218702097 7152863 complement(3977178..3977768) 1 NC_011750.1 rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase 3977768 slyD 7152863 slyD Escherichia coli IAI39 FKBP-type peptidyl-prolyl cis-trans isomerase YP_002409726.1 3977178 R 585057 CDS YP_002409727.1 218702098 7152862 complement(3977863..3978063) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3978063 yheV 7152862 yheV Escherichia coli IAI39 hypothetical protein YP_002409727.1 3977863 R 585057 CDS YP_002409728.1 218702099 7151894 complement(3979878..3980432) 1 NC_011750.1 required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG 3980432 kefG 7151894 kefG Escherichia coli IAI39 glutathione-regulated potassium-efflux system ancillary protein KefG YP_002409728.1 3979878 R 585057 CDS YP_002409729.1 218702100 7151897 3980560..3982473 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 3982473 yheS 7151897 yheS Escherichia coli IAI39 putative ABC transporter ATP-binding protein YP_002409729.1 3980560 D 585057 CDS YP_002409730.1 218702101 7154080 3982473..3983495 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9889164; Product type pe : putative enzyme; putative hydrolase 3983495 yheT 7154080 yheT Escherichia coli IAI39 putative hydrolase YP_002409730.1 3982473 D 585057 CDS YP_002409731.1 218702102 7154081 3983489..3983707 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3983707 yheU 7154081 yheU Escherichia coli IAI39 hypothetical protein YP_002409731.1 3983489 D 585057 CDS YP_002409732.1 218702103 7154082 3983761..3984630 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2559876; Product type e : enzyme; phosphoribulokinase 3984630 prkB 7154082 prkB Escherichia coli IAI39 phosphoribulokinase YP_002409732.1 3983761 D 585057 CDS YP_002409733.1 218702104 7152478 complement(3984685..3985089) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3985089 yhfA 7152478 yhfA Escherichia coli IAI39 hypothetical protein YP_002409733.1 3984685 R 585057 CDS YP_002409734.1 218702105 7151000 3985169..3985384 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3985384 7151000 ECIAI39_3840 Escherichia coli IAI39 hypothetical protein YP_002409734.1 3985169 D 585057 CDS YP_002409735.1 218702106 7150223 3985391..3986023 1 NC_011750.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 3986023 crp 7150223 crp Escherichia coli IAI39 cAMP-regulatory protein YP_002409735.1 3985391 D 585057 CDS YP_002409736.1 218702107 7150999 3986062..3988164 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3988164 yhfK 7150999 yhfK Escherichia coli IAI39 hypothetical protein YP_002409736.1 3986062 D 585057 CDS YP_002409737.1 218702108 7154086 complement(3988227..3989450) 1 NC_011750.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein 3989450 argD 7154086 argD Escherichia coli IAI39 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein YP_002409737.1 3988227 R 585057 CDS YP_002409738.1 218702109 7150763 complement(3989535..3990098) 1 NC_011750.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 3990098 pabA 7150763 pabA Escherichia coli IAI39 para-aminobenzoate synthase component II YP_002409738.1 3989535 R 585057 CDS YP_002409739.1 218702110 7152319 complement(3990130..3990732) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92021789, 94095125, 2007139, 2403545, 2546924, 7549107; Product type cp : cell process; cell filamentation protein Fic 3990732 fic 7152319 fic Escherichia coli IAI39 cell filamentation protein Fic YP_002409739.1 3990130 R 585057 CDS YP_002409740.1 218702111 7151324 complement(3990722..3990889) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3990889 yhfG 7151324 yhfG Escherichia coli IAI39 hypothetical protein YP_002409740.1 3990722 R 585057 CDS YP_002409741.1 218702112 7154085 complement(3990994..3991566) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90272647, 91175755, 1606970, 2001362, 2007139, 2190212, 2403545, 2546924, 8130188, 8180197; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase A 3991566 ppiA 7154085 ppiA Escherichia coli IAI39 peptidyl-prolyl cis-trans isomerase A YP_002409741.1 3990994 R 585057 CDS YP_002409742.1 218702113 7152460 3991837..3993018 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20509826; Product type pt : putative transporter; hypothetical protein 3993018 tsgA 7152460 tsgA Escherichia coli IAI39 hypothetical protein YP_002409742.1 3991837 D 585057 CDS YP_002409743.1 218702114 7153047 3993280..3995823 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93062014, 2200672, 2445993, 2543955; Product type e : enzyme; nitrite reductase, large subunit, NAD(P) H-binding 3995823 nirB 7153047 nirB Escherichia coli IAI39 nitrite reductase, large subunit, NAD(P) H-binding YP_002409743.1 3993280 D 585057 CDS YP_002409744.1 218702115 7152230 3995820..3996146 1 NC_011750.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 3996146 nirD 7152230 nirD Escherichia coli IAI39 nitrite reductase small subunit YP_002409744.1 3995820 D 585057 CDS YP_002409745.1 218702116 7152232 3996272..3997078 1 NC_011750.1 member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 3997078 nirC 7152232 nirC Escherichia coli IAI39 nitrite transporter NirC YP_002409745.1 3996272 D 585057 CDS YP_002409746.1 218702117 7152231 3997097..3998470 1 NC_011750.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 3998470 cysG 7152231 cysG Escherichia coli IAI39 siroheme synthase YP_002409746.1 3997097 D 585057 CDS YP_002409747.1 218702118 7151060 3998721..3998888 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3998888 yhfL 7151060 yhfL Escherichia coli IAI39 hypothetical protein YP_002409747.1 3998721 D 585057 CDS YP_002409748.1 218702119 7154087 complement(3998995..4000080) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4000080 yhfS 7154087 yhfS Escherichia coli IAI39 hypothetical protein YP_002409748.1 3998995 R 585057 CDS YP_002409749.1 218702120 7154088 complement(4000092..4001396) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4001396 yhfT 7154088 yhfT Escherichia coli IAI39 hypothetical protein YP_002409749.1 4000092 R 585057 CDS YP_002409750.1 218702121 7154089 complement(4001408..4001761) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4001761 yhfU 7154089 yhfU Escherichia coli IAI39 hypothetical protein YP_002409750.1 4001408 R 585057 CDS YP_002409751.1 218702122 7154090 complement(4001772..4002650) 1 NC_011750.1 phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE); putative hydrolase 4002650 php 7154090 php Escherichia coli IAI39 putative hydrolase YP_002409751.1 4001772 R 585057 CDS YP_002409752.1 218702123 7152417 complement(4002647..4003873) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative mutase 4003873 yhfW 7152417 yhfW Escherichia coli IAI39 putative mutase YP_002409752.1 4002647 R 585057 CDS YP_002409753.1 218702124 7154091 complement(4003873..4005036) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amino acid racemase 4005036 yhfX 7154091 yhfX Escherichia coli IAI39 putative amino acid racemase YP_002409753.1 4003873 R 585057 CDS YP_002409754.1 218702125 7154092 complement(4005120..4005482) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4005482 yhfY 7154092 yhfY Escherichia coli IAI39 hypothetical protein YP_002409754.1 4005120 R 585057 CDS YP_002409755.1 218702126 7154093 complement(4005499..4006404) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4006404 yhfZ 7154093 yhfZ Escherichia coli IAI39 hypothetical protein YP_002409755.1 4005499 R 585057 CDS YP_002409756.1 218702127 7154094 complement(4006564..4007568) 1 NC_011750.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 4007568 trpS 7154094 trpS Escherichia coli IAI39 tryptophanyl-tRNA synthetase YP_002409756.1 4006564 R 585057 CDS YP_002409757.1 218702128 7153038 complement(4007561..4008319) 1 NC_011750.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 4008319 gph 7153038 gph Escherichia coli IAI39 phosphoglycolate phosphatase YP_002409757.1 4007561 R 585057 CDS YP_002409758.1 218702129 7151577 complement(4008312..4008989) 1 NC_011750.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 4008989 rpe 7151577 rpe Escherichia coli IAI39 ribulose-phosphate 3-epimerase YP_002409758.1 4008312 R 585057 CDS YP_002409759.1 218702130 7152666 complement(4009007..4009843) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90136529, 92262475, 92272672, 2549371, 6300769, 7603433, 8341592; Product type e : enzyme; DNA adenine methylase 4009843 dam 7152666 dam Escherichia coli IAI39 DNA adenine methylase YP_002409759.1 4009007 R 585057 CDS YP_002409760.1 218702131 7151082 complement(4009950..4011236) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4011236 damX 7151082 damX Escherichia coli IAI39 hypothetical protein YP_002409760.1 4009950 R 585057 CDS YP_002409761.1 218702132 7151083 complement(4011328..4012416) 1 NC_011750.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 4012416 aroB 7151083 aroB Escherichia coli IAI39 3-dehydroquinate synthase YP_002409761.1 4011328 R 585057 CDS YP_002409762.1 218702133 7150776 complement(4012473..4012994) 1 NC_011750.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 4012994 aroK 7150776 aroK Escherichia coli IAI39 shikimate kinase I YP_002409762.1 4012473 R 585057 CDS YP_002409763.1 218702134 7150783 complement(4013395..4014633) 1 NC_011750.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; outer membrane porin HofQ 4014633 hofQ 7150783 hofQ Escherichia coli IAI39 outer membrane porin HofQ YP_002409763.1 4013395 R 585057 CDS YP_002409764.1 218702135 7151666 complement(4014545..4014949) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4014949 yrfA 7151666 yrfA Escherichia coli IAI39 hypothetical protein YP_002409764.1 4014545 R 585057 CDS YP_002409765.1 218702136 7154560 complement(4014939..4015379) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4015379 yrfB 7154560 yrfB Escherichia coli IAI39 hypothetical protein YP_002409765.1 4014939 R 585057 CDS YP_002409766.1 218702137 7154561 complement(4015363..4015902) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial assembly protein (pilN-like) 4015902 yrfC 7154561 yrfC Escherichia coli IAI39 putative fimbrial assembly protein (pilN-like) YP_002409766.1 4015363 R 585057 CDS YP_002409767.1 218702138 7154562 complement(4015902..4016681) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative pilus assembly protein 4016681 yrfD 7154562 yrfD Escherichia coli IAI39 putative pilus assembly protein YP_002409767.1 4015902 R 585057 CDS YP_002409768.1 218702139 7154563 4016801..4019353 1 NC_011750.1 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 4019353 mrcA 7154563 mrcA Escherichia coli IAI39 peptidoglycan synthetase YP_002409768.1 4016801 D 585057 CDS YP_002409769.1 218702140 7152122 complement(4019522..4020082) 1 NC_011750.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE 4020082 nudE 7152122 nudE Escherichia coli IAI39 ADP-ribose diphosphatase NudE YP_002409769.1 4019522 R 585057 CDS YP_002409770.1 218702141 7152265 4020402..4022537 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11553591; Product type r : regulator; intracellular growth attenuator protein 4022537 igaA 7152265 igaA Escherichia coli IAI39 intracellular growth attenuator protein YP_002409770.1 4020402 D 585057 CDS YP_002409771.1 218702142 7151759 4022602..4023270 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 4023270 yrfG 7151759 yrfG Escherichia coli IAI39 putative hydrolase YP_002409771.1 4022602 D 585057 CDS YP_002409772.1 218702143 7154564 4023281..4023682 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9867837, 10675343, 10675344; Product type f : factor; ribosome-associated heat shock protein Hsp15 4023682 hslR 7154564 hslR Escherichia coli IAI39 ribosome-associated heat shock protein Hsp15 YP_002409772.1 4023281 D 585057 CDS YP_002409773.1 218702144 7151682 4023707..4024585 1 NC_011750.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 4024585 hslO 7151682 hslO Escherichia coli IAI39 Hsp33-like chaperonin YP_002409773.1 4023707 D 585057 CDS YP_002409774.1 218702145 7151681 complement(4024719..4026443) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 20223645; Product type pm : putative membrane component; hypothetical protein 4026443 yhgE 7151681 yhgE Escherichia coli IAI39 hypothetical protein YP_002409774.1 4024719 R 585057 CDS YP_002409775.1 218702146 7154096 4026822..4028444 1 NC_011750.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 4028444 pck 7154096 pck Escherichia coli IAI39 phosphoenolpyruvate carboxykinase YP_002409775.1 4026822 D 585057 CDS YP_002409776.1 218702147 7152351 4028559..4028876 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4028876 7152351 ECIAI39_3882 Escherichia coli IAI39 hypothetical protein YP_002409776.1 4028559 D 585057 CDS YP_002409777.1 218702148 7150224 4028935..4029231 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2404279; Product type pr : putative regulator; putative HTH-type transcriptional regulator yiaG 4029231 7150224 ECIAI39_3883 Escherichia coli IAI39 putative HTH-type transcriptional regulator yiaG YP_002409777.1 4028935 D 585057 CDS YP_002409778.1 218702149 7150225 complement(4029263..4030615) 1 NC_011750.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein 4030615 envZ 7150225 envZ Escherichia coli IAI39 osmolarity sensor protein YP_002409778.1 4029263 R 585057 CDS YP_002409779.1 218702150 7151231 complement(4030612..4031331) 1 NC_011750.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator 4031331 ompR 7151231 ompR Escherichia coli IAI39 osmolarity response regulator YP_002409779.1 4030612 R 585057 CDS YP_002409780.1 218702151 7152296 4031559..4032035 1 NC_011750.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 4032035 greB 7152296 greB Escherichia coli IAI39 transcription elongation factor GreB YP_002409780.1 4031559 D 585057 CDS YP_002409781.1 218702152 7151584 4032132..4034453 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8755871; Product type f : factor; transcriptional accessory protein 4034453 yhgF 7151584 yhgF Escherichia coli IAI39 transcriptional accessory protein YP_002409781.1 4032132 D 585057 CDS YP_002409782.1 218702153 7154097 4034891..4035118 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012482, 8407793; Product type t : transporter; ferrous iron transport protein A 4035118 feoA 7154097 feoA Escherichia coli IAI39 ferrous iron transport protein A YP_002409782.1 4034891 D 585057 CDS YP_002409783.1 218702154 7151301 4035135..4037456 1 NC_011750.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 4037456 feoB 7151301 feoB Escherichia coli IAI39 ferrous iron transport protein B YP_002409783.1 4035135 D 585057 CDS YP_002409784.1 218702155 7151302 4037456..4037692 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4037692 yhgG 7151302 yhgG Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002409784.1 4037456 D 585057 CDS YP_002409785.1 218702156 7154098 4037895..4038773 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2678009; Product type ph : phenotype; hypothetical protein 4038773 yhgA 7154098 yhgA Escherichia coli IAI39 hypothetical protein YP_002409785.1 4037895 D 585057 CDS YP_002409786.1 218702157 7154095 complement(4038802..4039572) 1 NC_011750.1 Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH 4039572 bioH 7154095 bioH Escherichia coli IAI39 carboxylesterase BioH YP_002409786.1 4038802 R 585057 CDS YP_002409787.1 218702158 7150867 4039610..4040293 1 NC_011750.1 involved in high-affinity gluconate transport; gluconate periplasmic binding protein 4040293 gntX 7150867 gntX Escherichia coli IAI39 gluconate periplasmic binding protein YP_002409787.1 4039610 D 585057 CDS YP_002409788.1 218702159 7151574 4040352..4040927 1 NC_011750.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; putative DNA uptake protein 4040927 gntY 7151574 gntY Escherichia coli IAI39 putative DNA uptake protein YP_002409788.1 4040352 D 585057 CDS YP_002409789.1 218702160 7151575 4041279..4042595 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 4574689, 4582156, 93139975, 97141270, 98019089, 2845225, 3040894, 7984428, 9045817; Product type t : transporter; gluconate transporter, high-affinity GNT I system 4042595 gntT 7151575 gntT Escherichia coli IAI39 gluconate transporter, high-affinity GNT I system YP_002409789.1 4041279 D 585057 CDS YP_002409790.1 218702161 7151572 complement(4042640..4044724) 1 NC_011750.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 4044724 malQ 7151572 malQ Escherichia coli IAI39 4-alpha-glucanotransferase YP_002409790.1 4042640 R 585057 CDS YP_002409791.1 218702162 7152002 complement(4044734..4047127) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89033892, 10220320, 10469642, 2845225, 3037809, 3155826, 6283313, 6339728, 6986282, 9009262; Product type e : enzyme; maltodextrin phosphorylase 4047127 malP 7152002 malP Escherichia coli IAI39 maltodextrin phosphorylase YP_002409791.1 4044734 R 585057 CDS YP_002409792.1 218702163 7152001 4047750..4050455 1 NC_011750.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 4050455 malT 7152001 malT Escherichia coli IAI39 transcriptional regulator MalT YP_002409792.1 4047750 D 585057 CDS YP_002409793.1 218702164 7152004 complement(4050498..4051514) 1 NC_011750.1 catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase 4051514 rtcA 7152004 rtcA Escherichia coli IAI39 RNA 3'-terminal-phosphate cyclase YP_002409793.1 4050498 R 585057 CDS YP_002409794.1 218702165 7152758 complement(4051518..4052744) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9738023; hypothetical protein 4052744 rtcB 7152758 rtcB Escherichia coli IAI39 hypothetical protein YP_002409794.1 4051518 R 585057 CDS YP_002409795.1 218702166 7152759 4052933..4054531 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9738023, 3045764, 7920643, 7984428; Product type r : regulator; sigma 54-dependent transcriptional regulator of rtcBA expression 4054531 rtcR 7152759 rtcR Escherichia coli IAI39 sigma 54-dependent transcriptional regulator of rtcBA expression YP_002409795.1 4052933 D 585057 CDS YP_002409796.1 218702167 7152760 complement(4054513..4055271) 1 NC_011750.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR 4055271 glpR 7152760 glpR Escherichia coli IAI39 DNA-binding transcriptional repressor GlpR YP_002409796.1 4054513 R 585057 CDS YP_002409797.1 218702168 7151545 complement(4055288..4056118) 1 NC_011750.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG 4056118 glpG 7151545 glpG Escherichia coli IAI39 intramembrane serine protease GlpG YP_002409797.1 4055288 R 585057 CDS YP_002409798.1 218702169 7151542 complement(4056163..4056489) 1 NC_011750.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase 4056489 glpE 7151542 glpE Escherichia coli IAI39 thiosulfate sulfurtransferase YP_002409798.1 4056163 R 585057 CDS YP_002409799.1 218702170 7151540 4056679..4058184 1 NC_011750.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 4058184 glpD 7151540 glpD Escherichia coli IAI39 glycerol-3-phosphate dehydrogenase YP_002409799.1 4056679 D 585057 CDS YP_002409800.1 218702171 7151539 complement(4059001..4059993) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative ABC transporter ATP binding protein 4059993 7151539 ECIAI39_3907 Escherichia coli IAI39 putative ABC transporter ATP binding protein YP_002409800.1 4059001 R 585057 CDS YP_002409801.1 218702172 7150226 complement(4060019..4061536) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative ABC transporter ATP binding protein 4061536 7150226 ECIAI39_3908 Escherichia coli IAI39 putative ABC transporter ATP binding protein YP_002409801.1 4060019 R 585057 CDS YP_002409802.1 218702173 7150227 complement(4061653..4064100) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88330897, 91104907, 91236706, 2645169, 2975249, 3047129, 3097003; Product type e : enzyme; glycogen phosphorylase 4064100 glgP 7150227 glgP Escherichia coli IAI39 glycogen phosphorylase YP_002409802.1 4061653 R 585057 CDS YP_002409803.1 218702174 7151515 complement(4064119..4065552) 1 NC_011750.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 4065552 glgA 7151515 glgA Escherichia coli IAI39 glycogen synthase YP_002409803.1 4064119 R 585057 CDS YP_002409804.1 218702175 7151512 complement(4065552..4066847) 1 NC_011750.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 4066847 glgC 7151512 glgC Escherichia coli IAI39 glucose-1-phosphate adenylyltransferase YP_002409804.1 4065552 R 585057 CDS YP_002409805.1 218702176 7151514 complement(4066865..4068838) 1 NC_011750.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching enzyme 4068838 glgX 7151514 glgX Escherichia coli IAI39 glycogen debranching enzyme YP_002409805.1 4066865 R 585057 CDS YP_002409806.1 218702177 7151517 complement(4068835..4071021) 1 NC_011750.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 4071021 glgB 7151517 glgB Escherichia coli IAI39 glycogen branching enzyme YP_002409806.1 4068835 R 585057 CDS YP_002409807.1 218702178 7151513 complement(4071294..4072397) 1 NC_011750.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 4072397 asd 7151513 asd Escherichia coli IAI39 aspartate-semialdehyde dehydrogenase YP_002409807.1 4071294 R 585057 CDS YP_002409808.1 218702179 7150798 4072589..4073182 1 NC_011750.1 YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); putative dITP- and XTP- hydrolase 4073182 yhgN 7150798 yhgN Escherichia coli IAI39 putative dITP- and XTP- hydrolase YP_002409808.1 4072589 D 585057 CDS YP_002409809.1 218702180 7154099 complement(4073228..4074523) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4074523 7154099 ECIAI39_3916 Escherichia coli IAI39 hypothetical protein YP_002409809.1 4073228 R 585057 CDS YP_002409810.1 218702181 7150228 complement(4074430..4076526) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative superfamily II DNA helicase 4076526 7150228 ECIAI39_3917 Escherichia coli IAI39 putative superfamily II DNA helicase YP_002409810.1 4074430 R 585057 CDS YP_002409811.1 218702182 7150229 complement(4076666..4078006) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8655507, 9119199, 9135111, 97141270; Product type t : transporter; low affinity gluconate transporter 4078006 gntU 7150229 gntU Escherichia coli IAI39 low affinity gluconate transporter YP_002409811.1 4076666 R 585057 CDS YP_002409812.1 218702183 7151573 complement(4078010..4078537) 1 NC_011750.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase 1 4078537 gntK 7151573 gntK Escherichia coli IAI39 gluconate kinase 1 YP_002409812.1 4078010 R 585057 CDS YP_002409813.1 218702184 7151569 complement(4078676..4079671) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 9135111, 93139975, 9537375, 8655507; Product type r : regulator; DNA-binding transcriptional repressor 4079671 gntR 7151569 gntR Escherichia coli IAI39 DNA-binding transcriptional repressor YP_002409813.1 4078676 R 585057 CDS YP_002409814.1 218702185 7151571 complement(4079895..4080590) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4080590 yhhW 7151571 yhhW Escherichia coli IAI39 hypothetical protein YP_002409814.1 4079895 R 585057 CDS YP_002409815.1 218702186 7154110 complement(4080713..4081750) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10493123; Product type pe : putative enzyme; putative dehydrogenase 4081750 yhhX 7154110 yhhX Escherichia coli IAI39 putative dehydrogenase YP_002409815.1 4080713 R 585057 CDS YP_002409816.1 218702187 7152792 4082084..4082572 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase 4082572 yhhY 7152792 yhhY Escherichia coli IAI39 putative acetyltransferase YP_002409816.1 4082084 D 585057 CDS YP_002409817.1 218702188 7154112 4082808..4083986 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4083986 yhhZ 7154112 yhhZ Escherichia coli IAI39 hypothetical protein YP_002409817.1 4082808 D 585057 CDS YP_002409818.1 218702189 7154113 4083983..4084477 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4084477 yrhA 7154113 yrhA Escherichia coli IAI39 hypothetical protein YP_002409818.1 4083983 D 585057 CDS YP_002409819.1 218702190 7154565 4084927..4085211 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4085211 yrhB 7154565 yrhB Escherichia coli IAI39 hypothetical protein YP_002409819.1 4084927 D 585057 CDS YP_002409820.1 218702191 7154566 complement(4085249..4087021) 1 NC_011750.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase 4087021 ggt 7154566 ggt Escherichia coli IAI39 gamma-glutamyltranspeptidase YP_002409820.1 4085249 R 585057 CDS YP_002409821.1 218702192 7151502 4087114..4087554 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4087554 yhhA 7151502 yhhA Escherichia coli IAI39 hypothetical protein YP_002409821.1 4087114 D 585057 CDS YP_002409822.1 218702193 7154100 complement(4087541..4088284) 1 NC_011750.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; cytoplasmic glycerophosphodiester phosphodiesterase 4088284 ugpQ 7154100 ugpQ Escherichia coli IAI39 cytoplasmic glycerophosphodiester phosphodiesterase YP_002409822.1 4087541 R 585057 CDS YP_002409823.1 218702194 7153085 complement(4088281..4089351) 1 NC_011750.1 part of the UgpABCE glycerol-3-phosphate uptake system; glycerol-3-phosphate transporter ATP-binding subunit 4089351 ugpC 7153085 ugpC Escherichia coli IAI39 glycerol-3-phosphate transporter ATP-binding subunit YP_002409823.1 4088281 R 585057 CDS YP_002409824.1 218702195 7153083 complement(4089353..4090198) 1 NC_011750.1 with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein 4090198 ugpE 7153083 ugpE Escherichia coli IAI39 glycerol-3-phosphate transporter membrane protein YP_002409824.1 4089353 R 585057 CDS YP_002409825.1 218702196 7153084 complement(4090195..4091082) 1 NC_011750.1 with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease 4091082 ugpA 7153084 ugpA Escherichia coli IAI39 glycerol-3-phosphate transporter permease YP_002409825.1 4090195 R 585057 CDS YP_002409826.1 218702197 7153081 complement(4091180..4092496) 1 NC_011750.1 with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein 4092496 ugpB 7153081 ugpB Escherichia coli IAI39 glycerol-3-phosphate transporter periplasmic binding protein YP_002409826.1 4091180 R 585057 CDS YP_002409827.1 218702198 7153082 complement(4092856..4093602) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4093602 7153082 ECIAI39_3934 Escherichia coli IAI39 hypothetical protein YP_002409827.1 4092856 R 585057 CDS YP_002409828.1 218702199 7150230 complement(4093721..4094434) 1 NC_011750.1 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 4094434 livF 7150230 livF Escherichia coli IAI39 leucine/isoleucine/valine transporter ATP-binding subunit YP_002409828.1 4093721 R 585057 CDS YP_002409829.1 218702200 7151940 complement(4094436..4095203) 1 NC_011750.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 4095203 livG 7151940 livG Escherichia coli IAI39 leucine/isoleucine/valine transporter ATP-binding subunit YP_002409829.1 4094436 R 585057 CDS YP_002409830.1 218702201 7151941 complement(4095200..4096477) 1 NC_011750.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease subunit 4096477 livM 7151941 livM Escherichia coli IAI39 leucine/isoleucine/valine transporter permease subunit YP_002409830.1 4095200 R 585057 CDS YP_002409831.1 218702202 7151945 complement(4096474..4097400) 1 NC_011750.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid transporter permease subunit LivH 4097400 livH 7151945 livH Escherichia coli IAI39 branched-chain amino acid transporter permease subunit LivH YP_002409831.1 4096474 R 585057 CDS YP_002409832.1 218702203 7151942 complement(4097448..4098557) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702302, 90307651, 2195019, 2649683, 3891753, 4077929, 9298646, 9298646; Product type t : transporter; leucine ABC transporter subunit periplasmic-binding protein 4098557 livK 7151942 livK Escherichia coli IAI39 leucine ABC transporter subunit periplasmic-binding protein YP_002409832.1 4097448 R 585057 CDS YP_002409833.1 218702204 7151944 4098981..4099364 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4099364 yhhK 7151944 yhhK Escherichia coli IAI39 hypothetical protein YP_002409833.1 4098981 D 585057 CDS YP_002409834.1 218702205 7154103 complement(4099552..4100655) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702302, 90307651, 2195019, 2649682, 328304, 3891753, 4077929, 9298646, 10972807; Product type t : transporter; leucine/isoleucine/valine ABC transporter subunit periplasmic-binding protein 4100655 livJ 7154103 livJ Escherichia coli IAI39 leucine/isoleucine/valine ABC transporter subunit periplasmic-binding protein YP_002409834.1 4099552 R 585057 CDS YP_002409835.1 218702206 7151943 complement(4100927..4101781) 1 NC_011750.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 4101781 rpoH 7151943 rpoH Escherichia coli IAI39 RNA polymerase factor sigma-32 YP_002409835.1 4100927 R 585057 CDS YP_002409836.1 218702207 7152708 complement(4102026..4103084) 1 NC_011750.1 putative ABC transporter, membrane protein; cell division protein FtsX 4103084 ftsX 7152708 ftsX Escherichia coli IAI39 cell division protein FtsX YP_002409836.1 4102026 R 585057 CDS YP_002409837.1 218702208 7151443 complement(4103077..4103745) 1 NC_011750.1 putative ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE 4103745 ftsE 7151443 ftsE Escherichia coli IAI39 cell division protein FtsE YP_002409837.1 4103077 R 585057 CDS YP_002409838.1 218702209 7151435 complement(4103748..4105235) 1 NC_011750.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY 4105235 ftsY 7151435 ftsY Escherichia coli IAI39 cell division protein FtsY YP_002409838.1 4103748 R 585057 CDS YP_002409839.1 218702210 7151444 4105385..4105981 1 NC_011750.1 catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 4105981 rsmD 7151444 rsmD Escherichia coli IAI39 16S rRNA m(2)G966-methyltransferase YP_002409839.1 4105385 D 585057 CDS YP_002409840.1 218702211 7154101 4105971..4106240 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4106240 yhhL 7154101 yhhL Escherichia coli IAI39 hypothetical protein YP_002409840.1 4105971 D 585057 CDS YP_002409841.1 218702212 7154104 complement(4106243..4106602) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4106602 yhhM 7154104 yhhM Escherichia coli IAI39 hypothetical protein YP_002409841.1 4106243 R 585057 CDS YP_002409842.1 218702213 7154105 4106743..4107369 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4107369 yhhN 7154105 yhhN Escherichia coli IAI39 hypothetical protein YP_002409842.1 4106743 D 585057 CDS YP_002409843.1 218702214 7154106 4107443..4109641 1 NC_011750.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 4109641 zntA 7154106 zntA Escherichia coli IAI39 zinc/cadmium/mercury/lead-transporting ATPase YP_002409843.1 4107443 D 585057 CDS YP_002409844.1 218702215 7154590 complement(4109743..4109988) 1 NC_011750.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 4109988 tusA 7154590 tusA Escherichia coli IAI39 sulfur transfer protein SirA YP_002409844.1 4109743 R 585057 CDS YP_002409845.1 218702216 7153057 4110209..4110874 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4110874 yhhQ 7153057 yhhQ Escherichia coli IAI39 hypothetical protein YP_002409845.1 4110209 D 585057 CDS YP_002409846.1 218702217 7154107 4110947..4111504 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12558182, 8752353; Product type t : transporter; hypothetical protein 4111504 dcrB 7154107 dcrB Escherichia coli IAI39 hypothetical protein YP_002409846.1 4110947 D 585057 CDS YP_002409847.1 218702218 7151093 complement(4111508..4112725) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; major facilitator superfamily transporter 4112725 yhhS 7151093 yhhS Escherichia coli IAI39 major facilitator superfamily transporter YP_002409847.1 4111508 R 585057 CDS YP_002409848.1 218702219 7154108 4112857..4113906 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4113906 yhhT 7154108 yhhT Escherichia coli IAI39 hypothetical protein YP_002409848.1 4112857 D 585057 CDS YP_002409849.1 218702220 7154109 4113961..4114548 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20092861, 10625633, 8939709; Product type e : enzyme; holo-(acyl carrier protein) synthase 2 4114548 acpT 7154109 acpT Escherichia coli IAI39 holo-(acyl carrier protein) synthase 2 YP_002409849.1 4113961 D 585057 CDS YP_002409850.1 218702221 7150671 4114659..4116233 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12960164, 7934931, 92077434, 7867647; Product type t : transporter; nickel ABC transporter subunit periplasmic-binding protein 4116233 nikA 7150671 nikA Escherichia coli IAI39 nickel ABC transporter subunit periplasmic-binding protein YP_002409850.1 4114659 D 585057 CDS YP_002409851.1 218702222 7152224 4116233..4117177 1 NC_011750.1 with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 4117177 nikB 7152224 nikB Escherichia coli IAI39 nickel transporter permease NikB YP_002409851.1 4116233 D 585057 CDS YP_002409852.1 218702223 7152225 4117174..4118007 1 NC_011750.1 with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 4118007 nikC 7152225 nikC Escherichia coli IAI39 nickel transporter permease NikC YP_002409852.1 4117174 D 585057 CDS YP_002409853.1 218702224 7152226 4118007..4118771 1 NC_011750.1 with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 4118771 nikD 7152226 nikD Escherichia coli IAI39 nickel transporter ATP-binding protein NikD YP_002409853.1 4118007 D 585057 CDS YP_002409854.1 218702225 7152227 4118768..4119574 1 NC_011750.1 with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 4119574 nikE 7152227 nikE Escherichia coli IAI39 nickel transporter ATP-binding protein NikE YP_002409854.1 4118768 D 585057 CDS YP_002409855.1 218702226 7152228 4119579..4119980 1 NC_011750.1 Inhibits transcription at high concentrations of nickel; nickel responsive regulator 4119980 nikR 7152228 nikR Escherichia coli IAI39 nickel responsive regulator YP_002409855.1 4119579 D 585057 CDS YP_002409856.1 218702227 7152229 4120170..4120925 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4120925 7152229 ECIAI39_3963 Escherichia coli IAI39 putative transcriptional regulator YP_002409856.1 4120170 D 585057 CDS YP_002409857.1 218702228 7150231 4120950..4121423 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system enzyme subunit IIA 4121423 7150231 ECIAI39_3964 Escherichia coli IAI39 putative phosphotransferase system enzyme subunit IIA YP_002409857.1 4120950 D 585057 CDS YP_002409858.1 218702229 7150232 4121420..4121701 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system enzyme IIB 4121701 7150232 ECIAI39_3965 Escherichia coli IAI39 putative phosphotransferase system enzyme IIB YP_002409858.1 4121420 D 585057 CDS YP_002409859.1 218702230 7150233 4121745..4123133 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative phosphotransferase system permease component IIC 4123133 7150233 ECIAI39_3966 Escherichia coli IAI39 putative phosphotransferase system permease component IIC YP_002409859.1 4121745 D 585057 CDS YP_002409860.1 218702231 7150234 4123126..4124634 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative carbohydrate kinase 4124634 7150234 ECIAI39_3967 Escherichia coli IAI39 putative carbohydrate kinase YP_002409860.1 4123126 D 585057 CDS YP_002409861.1 218702232 7150235 4124624..4124893 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative phosphocarrier HPr protein of a carbohydrate phosphotransferase system 4124893 7150235 ECIAI39_3968 Escherichia coli IAI39 putative phosphocarrier HPr protein of a carbohydrate phosphotransferase system YP_002409861.1 4124624 D 585057 CDS YP_002409862.1 218702233 7150236 4124925..4125785 1 NC_011750.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; putative fructose-1,6-bisphosphate aldolase 4125785 gatY 7150236 gatY Escherichia coli IAI39 putative fructose-1,6-bisphosphate aldolase YP_002409862.1 4124925 D 585057 CDS YP_002409863.1 218702234 7150237 complement(4125835..4126194) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4126194 7150237 ECIAI39_3970 Escherichia coli IAI39 hypothetical protein YP_002409863.1 4125835 R 585057 CDS YP_002409864.1 218702235 7150238 complement(4126539..4127663) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter membrane protein 4127663 yhhJ 7150238 yhhJ Escherichia coli IAI39 putative ABC transporter membrane protein YP_002409864.1 4126539 R 585057 CDS YP_002409865.1 218702236 7154102 complement(4127663..4130398) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20074572; Product type e : enzyme; ribosome-associated ATPase/membrane protein 4130398 rbbA 7154102 rbbA Escherichia coli IAI39 ribosome-associated ATPase/membrane protein YP_002409865.1 4127663 R 585057 CDS YP_002409866.1 218702237 7152568 complement(4130395..4131462) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative HlyD family secretion protein 4131462 yhiI 7152568 yhiI Escherichia coli IAI39 putative HlyD family secretion protein YP_002409866.1 4130395 R 585057 CDS YP_002409867.1 218702238 7154116 complement(4131828..4133450) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4133450 yhiJ 7154116 yhiJ Escherichia coli IAI39 hypothetical protein YP_002409867.1 4131828 R 585057 CDS YP_002409868.1 218702239 7154117 4133811..4135157 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element 4135157 insG 7154117 insG Escherichia coli IAI39 putative IS4 transposase; KpLE2 phage-like element YP_002409868.1 4133811 D 585057 CDS YP_002409869.1 218702240 7151817 complement(4135146..4136825) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4136825 7151817 ECIAI39_3976 Escherichia coli IAI39 hypothetical protein YP_002409869.1 4135146 R 585057 CDS YP_002409870.1 218702241 7150239 complement(4136716..4136925) 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 4136925 7150239 ECIAI39_3977 Escherichia coli IAI39 hypothetical protein YP_002409870.1 4136716 R 585057 CDS YP_002409871.1 218702242 7150240 complement(4137054..4137152) 1 NC_011750.1 hypothetical protein 4137152 7150240 ECIAI39_3979 Escherichia coli IAI39 hypothetical protein YP_002409871.1 4137054 R 585057 CDS YP_002409872.1 218702243 7150241 4137124..4138176 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4138176 yhiM 7150241 yhiM Escherichia coli IAI39 hypothetical protein YP_002409872.1 4137124 D 585057 CDS YP_002409873.1 218702244 7154118 complement(4137924..4138256) 1 NC_011750.1 hypothetical protein 4138256 7154118 ECIAI39_3980 Escherichia coli IAI39 hypothetical protein YP_002409873.1 4137924 R 585057 CDS YP_002409874.1 218702245 7150242 complement(4138491..4139693) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 4139693 yhiN 7150242 yhiN Escherichia coli IAI39 putative oxidoreductase YP_002409874.1 4138491 R 585057 CDS YP_002409875.1 218702246 7154119 4139925..4141424 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87014120; Product type t : transporter; phosphate transporter, low-affinity 4141424 pitA 7154119 pitA Escherichia coli IAI39 phosphate transporter, low-affinity YP_002409875.1 4139925 D 585057 CDS YP_002409876.1 218702247 7152423 complement(4141495..4141830) 1 NC_011750.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB 4141830 yhiO 7152423 yhiO Escherichia coli IAI39 universal stress protein UspB YP_002409876.1 4141495 R 585057 CDS YP_002409877.1 218702248 7154120 4142221..4142655 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 93086426, 93308072, 94203056, 10499297, 10652104, 10931298, 11157932, 1453957, 8506346, 8932299, 9298646, 9405142; Product type f : factor; universal stress global response regulator 4142655 uspA 7154120 uspA Escherichia coli IAI39 universal stress global response regulator YP_002409877.1 4142221 D 585057 CDS YP_002409878.1 218702249 7153108 4142971..4144440 1 NC_011750.1 member of the POT family of peptide transporters; probable proton-dependent peptide transporter function; inner membrane transporter YhiP 4144440 yhiP 7153108 yhiP Escherichia coli IAI39 inner membrane transporter YhiP YP_002409878.1 4142971 D 585057 CDS YP_002409879.1 218702250 7154121 complement(4144489..4145241) 1 NC_011750.1 predicted SAM-dependent methyltransferase; putative methyltransferase 4145241 yhiQ 7154121 yhiQ Escherichia coli IAI39 putative methyltransferase YP_002409879.1 4144489 R 585057 CDS YP_002409880.1 218702251 7154122 complement(4145249..4147291) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92394891, 1325967, 8366062; Product type e : enzyme; oligopeptidase A 4147291 prlC 7154122 prlC Escherichia coli IAI39 oligopeptidase A YP_002409880.1 4145249 R 585057 CDS YP_002409881.1 218702252 7152479 4147494..4148336 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11591672; Product type pe : putative enzyme; putative DNA (exogenous) processing protein 4148336 yhiR 7152479 yhiR Escherichia coli IAI39 putative DNA (exogenous) processing protein YP_002409881.1 4147494 D 585057 CDS YP_002409882.1 218702253 7154123 4148408..4149760 1 NC_011750.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 4149760 gor 7154123 gor Escherichia coli IAI39 glutathione reductase YP_002409882.1 4148408 D 585057 CDS YP_002409883.1 218702254 7151576 complement(4149814..4149963) 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 4149963 7151576 ECIAI39_3991 Escherichia coli IAI39 hypothetical protein YP_002409883.1 4149814 R 585057 CDS YP_002409884.1 218702255 7150243 4149919..4150098 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 4150098 7150243 ECIAI39_3992 Escherichia coli IAI39 hypothetical protein YP_002409884.1 4149919 D 585057 CDS YP_002409885.1 218702256 7150244 4150636..4150989 1 NC_011750.1 regulates the expression of of the arsRBC involved in resistance to arsenic; DNA-binding transcriptional repressor ArsR 4150989 arsR 7150244 arsR Escherichia coli IAI39 DNA-binding transcriptional repressor ArsR YP_002409885.1 4150636 D 585057 CDS YP_002409886.1 218702257 7150789 4151044..4152333 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15004242, 95355341, 1535622, 7721697; Product type t : transporter; arsenite/antimonite transporter 4152333 arsB 7150789 arsB Escherichia coli IAI39 arsenite/antimonite transporter YP_002409886.1 4151044 D 585057 CDS YP_002409887.1 218702258 7150787 4152346..4152771 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95355341, 7721697; Product type e : enzyme; arsenate reductase 4152771 arsC 7150787 arsC Escherichia coli IAI39 arsenate reductase YP_002409887.1 4152346 D 585057 CDS YP_002409888.1 218702259 7150788 complement(4152792..4153112) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4153112 7150788 ECIAI39_3996 Escherichia coli IAI39 hypothetical protein YP_002409888.1 4152792 R 585057 CDS YP_002409889.1 218702260 7150245 4153208..4154221 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 4154221 7150245 ECIAI39_3997 Escherichia coli IAI39 hypothetical protein YP_002409889.1 4153208 D 585057 CDS YP_002409890.1 218702261 7150246 4154802..4156025 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4156025 7150246 ECIAI39_3998 Escherichia coli IAI39 hypothetical protein YP_002409890.1 4154802 D 585057 CDS YP_002409891.1 218702262 7150247 4156271..4156837 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293775, 8022277; Product type lp : lipoprotein; outer membrane lipoprotein 4156837 slp 7150247 slp Escherichia coli IAI39 outer membrane lipoprotein YP_002409891.1 4156271 D 585057 CDS YP_002409892.1 218702263 7152858 4156990..4157520 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8022277; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4157520 yhiF 7152858 yhiF Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002409892.1 4156990 D 585057 CDS YP_002409893.1 218702264 7154115 complement(4157581..4158609) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16275907; Product type e : enzyme; Heme oxygenase 4158609 chuS 7154115 chuS Escherichia coli IAI39 Heme oxygenase YP_002409893.1 4157581 R 585057 CDS YP_002409894.1 218702265 7150945 complement(4158658..4160640) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11179376, 7768795, 9393841, 9680204, 9157252; Product type t : transporter; outer membrane hemin receptor 4160640 chuA 7150945 chuA Escherichia coli IAI39 outer membrane hemin receptor YP_002409894.1 4158658 R 585057 CDS YP_002409895.1 218702266 7150944 4160477..4160737 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 4160737 7150944 ECIAI39_4003 Escherichia coli IAI39 hypothetical protein YP_002409895.1 4160477 D 585057 CDS YP_002409896.1 218702267 7150248 4161246..4162238 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7768795, 9393841, 9680204; Product type pt : putative transporter; putative periplasmic binding protein 4162238 chuT 7150248 chuT Escherichia coli IAI39 putative periplasmic binding protein YP_002409896.1 4161246 D 585057 CDS YP_002409897.1 218702268 7150946 4162258..4163595 1 NC_011750.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4163595 7150946 ECIAI39_4005 Escherichia coli IAI39 coproporphyrinogen III oxidase YP_002409897.1 4162258 D 585057 CDS YP_002409898.1 218702269 7150249 4163608..4164102 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4164102 7150249 ECIAI39_4006 Escherichia coli IAI39 hypothetical protein YP_002409898.1 4163608 D 585057 CDS YP_002409899.1 218702270 7150250 4164102..4164725 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4164725 7150250 ECIAI39_4007 Escherichia coli IAI39 hypothetical protein YP_002409899.1 4164102 D 585057 CDS YP_002409900.1 218702271 7150251 4164774..4165766 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative hemin transport system permease 4165766 chuU 7150251 chuU Escherichia coli IAI39 putative hemin transport system permease YP_002409900.1 4164774 D 585057 CDS YP_002409901.1 218702272 7150947 4165733..4166533 1 NC_011750.1 with HmuTU is involved in the transport of hemin; hemin importer ATP-binding subunit 4166533 hmuV 7150947 hmuV Escherichia coli IAI39 hemin importer ATP-binding subunit YP_002409901.1 4165733 D 585057 CDS YP_002409902.1 218702273 7150948 complement(4166585..4167232) 1 NC_011750.1 inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli; putative Mg(2+) transport ATPase 4167232 yhiD 7150948 yhiD Escherichia coli IAI39 putative Mg(2+) transport ATPase YP_002409902.1 4166585 R 585057 CDS YP_002409903.1 218702274 7154114 complement(4167296..4167622) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94064579, 8885264, 12071744, 8244952, 8455549, 9298646, 9868784; Product type pf : putative factor; acid-resistance protein 4167622 hdeB 7154114 hdeB Escherichia coli IAI39 acid-resistance protein YP_002409903.1 4167296 R 585057 CDS YP_002409904.1 218702275 7151619 complement(4167738..4168070) 1 NC_011750.1 inactive form; acid-resistance protein 4168070 hdeA 7151619 hdeA Escherichia coli IAI39 acid-resistance protein YP_002409904.1 4167738 R 585057 CDS YP_002409905.1 218702276 7151618 4168325..4168897 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94064579, 8244952, 8455549; Product type pm : putative membrane component; acid-resistance membrane protein 4168897 hdeD 7151618 hdeD Escherichia coli IAI39 acid-resistance membrane protein YP_002409905.1 4168325 D 585057 CDS YP_002409906.1 218702277 7151620 4169695..4170222 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12399493, 12940989, 14702398; Product type r : regulator; DNA-binding transcriptional activator 4170222 gadE 7151620 gadE Escherichia coli IAI39 DNA-binding transcriptional activator YP_002409906.1 4169695 D 585057 CDS YP_002409907.1 218702278 7151466 4170560..4171717 1 NC_011750.1 with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds; multidrug efflux system protein MdtE 4171717 mdtE 7151466 mdtE Escherichia coli IAI39 multidrug efflux system protein MdtE YP_002409907.1 4170560 D 585057 CDS YP_002409908.1 218702279 7152032 4171742..4174855 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803; Product type t : transporter; multidrug transporter, RpoS-dependent 4174855 mdtF 7152032 mdtF Escherichia coli IAI39 multidrug transporter, RpoS-dependent YP_002409908.1 4171742 D 585057 CDS YP_002409909.1 218702280 7152033 complement(4175218..4175946) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12446650; Product type r : regulator; DNA-binding transcriptional activator 4175946 gadW 7152033 gadW Escherichia coli IAI39 DNA-binding transcriptional activator YP_002409909.1 4175218 R 585057 CDS YP_002409910.1 218702281 7151469 complement(4176315..4177139) 1 NC_011750.1 regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX 4177139 gadX 7151469 gadX Escherichia coli IAI39 DNA-binding transcriptional regulator GadX YP_002409910.1 4176315 R 585057 CDS YP_002409911.1 218702282 7151468 complement(4177508..4178908) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92155241, 92394884, 99406302, 1522060, 1740158, 7764225, 9298646; Product type e : enzyme; glutamate decarboxylase A, PLP-dependent 4178908 gadA 7151468 gadA Escherichia coli IAI39 glutamate decarboxylase A, PLP-dependent YP_002409911.1 4177508 R 585057 CDS YP_002409912.1 218702283 7151463 complement(4179119..4180516) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8163487, 14563563; Product type e : enzyme; cytochrome C peroxidase (cpp-like) 4180516 yhjA 7151463 yhjA Escherichia coli IAI39 cytochrome C peroxidase (cpp-like) YP_002409912.1 4179119 R 585057 CDS YP_002409913.1 218702284 7154124 4180921..4182570 1 NC_011750.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 4182570 treF 7154124 treF Escherichia coli IAI39 trehalase YP_002409913.1 4180921 D 585057 CDS YP_002409914.1 218702285 7153020 complement(4182621..4183223) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding response regulator in two-component regulatory system 4183223 yhjB 7153020 yhjB Escherichia coli IAI39 putative DNA-binding response regulator in two-component regulatory system YP_002409914.1 4182621 R 585057 CDS YP_002409915.1 218702286 7154125 4183670..4184641 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4184641 yhjC 7154125 yhjC Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002409915.1 4183670 D 585057 CDS YP_002409916.1 218702287 7154126 4184690..4185703 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4185703 yhjD 7154126 yhjD Escherichia coli IAI39 hypothetical protein YP_002409916.1 4184690 D 585057 CDS YP_002409917.1 218702288 7154127 4186095..4187417 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4187417 yhjE 7154127 yhjE Escherichia coli IAI39 putative transporter YP_002409917.1 4186095 D 585057 CDS YP_002409918.1 218702289 7154128 complement(4187596..4189671) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane biogenesis protein 4189671 yhjG 7154128 yhjG Escherichia coli IAI39 putative outer membrane biogenesis protein YP_002409918.1 4187596 R 585057 CDS YP_002409919.1 218702290 7154129 complement(4189726..4190493) 1 NC_011750.1 in Escherichia coli this protein is involved in flagellar function; EAL domain-containing protein 4190493 yhjH 7154129 yhjH Escherichia coli IAI39 EAL domain-containing protein YP_002409919.1 4189726 R 585057 CDS YP_002409920.1 218702291 7154130 4190725..4191654 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4359651, 13813474; Product type e : enzyme; ketodeoxygluconokinase 4191654 kdgK 7154130 kdgK Escherichia coli IAI39 ketodeoxygluconokinase YP_002409920.1 4190725 D 585057 CDS YP_002409921.1 218702292 7151877 complement(4191751..4193247) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pe : putative enzyme; putative zinc-dependent peptidase 4193247 yhjJ 7151877 yhjJ Escherichia coli IAI39 putative zinc-dependent peptidase YP_002409921.1 4191751 R 585057 CDS YP_002409922.1 218702293 7154131 complement(4193467..4194753) 1 NC_011750.1 involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA 4194753 dctA 7154131 dctA Escherichia coli IAI39 C4-dicarboxylate transporter DctA YP_002409922.1 4193467 R 585057 CDS YP_002409923.1 218702294 7151094 complement(4194936..4196885) 1 NC_011750.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a putative phosphodiesterase protein from E. coli; putative phosphodiesterase 4196885 yhjK 7151094 yhjK Escherichia coli IAI39 putative phosphodiesterase YP_002409923.1 4194936 R 585057 CDS YP_002409924.1 218702295 7154132 complement(4197006..4200479) 1 NC_011750.1 cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA; cellulose synthase subunit BcsC 4200479 bcsC 7154132 bcsC Escherichia coli IAI39 cellulose synthase subunit BcsC YP_002409924.1 4197006 R 585057 CDS YP_002409925.1 218702296 7150845 complement(4200461..4201567) 1 NC_011750.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase 4201567 bcsZ 7150845 bcsZ Escherichia coli IAI39 endo-1,4-D-glucanase YP_002409925.1 4200461 R 585057 CDS YP_002409926.1 218702297 7150850 complement(4201574..4203913) 1 NC_011750.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein 4203913 bcsB 7150850 bcsB Escherichia coli IAI39 cellulose synthase regulator protein YP_002409926.1 4201574 R 585057 CDS YP_002409927.1 218702298 7150844 complement(4203924..4206530) 1 NC_011750.1 polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis; cellulose synthase catalytic subunit 4206530 bcsA 7150844 bcsA Escherichia coli IAI39 cellulose synthase catalytic subunit YP_002409927.1 4203924 R 585057 CDS YP_002409928.1 218702299 7150843 complement(4206520..4207272) 1 NC_011750.1 cell division protein 4207272 7150843 ECIAI39_4038 Escherichia coli IAI39 cell division protein YP_002409928.1 4206520 R 585057 CDS YP_002409929.1 218702300 7150252 complement(4207284..4207472) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4207472 yhjR 7150252 yhjR Escherichia coli IAI39 hypothetical protein YP_002409929.1 4207284 R 585057 CDS YP_002409930.1 218702301 7154133 4207744..4209315 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929533, 11260463; Product type pe : putative enzyme; putative cellulose biosynthesis protease 4209315 bcsE 7154133 bcsE Escherichia coli IAI39 putative cellulose biosynthesis protease YP_002409930.1 4207744 D 585057 CDS YP_002409931.1 218702302 7150846 4209312..4209503 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4209503 bcsF 7150846 bcsF Escherichia coli IAI39 hypothetical protein YP_002409931.1 4209312 D 585057 CDS YP_002409932.1 218702303 7150848 4209927..4211273 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase, IS4 4211273 insG 7150848 insG Escherichia coli IAI39 transposase, IS4 YP_002409932.1 4209927 D 585057 CDS YP_002409933.1 218702304 7152586 complement(4214428..4214589) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4214589 7152586 ECIAI39_4047 Escherichia coli IAI39 hypothetical protein YP_002409933.1 4214428 R 585057 CDS YP_002409934.1 218702305 7150253 4214739..4216010 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15901718; Product type t : transporter; transporter 4216010 yhjV 7150253 yhjV Escherichia coli IAI39 transporter YP_002409934.1 4214739 D 585057 CDS YP_002409935.1 218702306 7154134 complement(4216040..4217044) 1 NC_011750.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit 4217044 dppF 7154134 dppF Escherichia coli IAI39 dipeptide transporter ATP-binding subunit YP_002409935.1 4216040 R 585057 CDS YP_002409936.1 218702307 7151170 complement(4217041..4218024) 1 NC_011750.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit 4218024 dppD 7151170 dppD Escherichia coli IAI39 dipeptide transporter ATP-binding subunit YP_002409936.1 4217041 R 585057 CDS YP_002409937.1 218702308 7151169 complement(4218035..4218937) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7536291; Product type t : transporter; dipeptide transporter 4218937 dppC 7151169 dppC Escherichia coli IAI39 dipeptide transporter YP_002409937.1 4218035 R 585057 CDS YP_002409938.1 218702309 7151168 complement(4218947..4219966) 1 NC_011750.1 transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB 4219966 dppB 7151168 dppB Escherichia coli IAI39 dipeptide transporter permease DppB YP_002409938.1 4218947 R 585057 CDS YP_002409939.1 218702310 7151167 complement(4220117..4221724) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100289, 92065799, 1702779, 1956284, 7536291, 8527431, 8563629, 9298646, 9600841, 9740056, 10972807; Product type t : transporter; dipeptide ABC transporter periplasmic-binding protein 4221724 dppA 7151167 dppA Escherichia coli IAI39 dipeptide ABC transporter periplasmic-binding protein YP_002409939.1 4220117 R 585057 CDS YP_002409940.1 218702311 7150589 complement(4222636..4224327) 1 NC_011750.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase 4224327 eptB 7150589 eptB Escherichia coli IAI39 phosphoethanolamine transferase YP_002409940.1 4222636 R 585057 CDS YP_002409941.1 218702312 7151237 complement(4224651..4225859) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4225859 yhjX 7151237 yhjX Escherichia coli IAI39 putative transporter YP_002409941.1 4224651 R 585057 CDS YP_002409942.1 218702313 7154135 complement(4226088..4226786) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4226786 yhjY 7154135 yhjY Escherichia coli IAI39 hypothetical protein YP_002409942.1 4226088 R 585057 CDS YP_002409943.1 218702314 7154136 4226944..4227507 1 NC_011750.1 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyl-adenine DNA glycosylase I 4227507 tag 7154136 tag Escherichia coli IAI39 3-methyl-adenine DNA glycosylase I YP_002409943.1 4226944 D 585057 CDS YP_002409944.1 218702315 7152937 4227504..4227944 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11237876; Product type pe : putative enzyme; hypothetical protein 4227944 yiaC 7152937 yiaC Escherichia coli IAI39 hypothetical protein YP_002409944.1 4227504 D 585057 CDS YP_002409945.1 218702316 7154139 complement(4227913..4230192) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82119950, 90202748, 2180922, 374979; Product type e : enzyme; biotin sulfoxide reductase 4230192 bisC 7154139 bisC Escherichia coli IAI39 biotin sulfoxide reductase YP_002409945.1 4227913 R 585057 CDS YP_002409946.1 218702317 7150870 4230399..4231058 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein 4231058 yiaD 7150870 yiaD Escherichia coli IAI39 putative outer membrane lipoprotein YP_002409946.1 4230399 D 585057 CDS YP_002409947.1 218702318 7154140 4231162..4232136 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15801772, 11237876, 99030322, 99357626, 9298646, 9811658; Product type e : enzyme; 2-oxo-carboxylic acid reductase 4232136 tiaE 7154140 tiaE Escherichia coli IAI39 2-oxo-carboxylic acid reductase YP_002409947.1 4231162 D 585057 CDS YP_002409948.1 218702319 7152985 complement(4232186..4232896) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4232896 yiaF 7152985 yiaF Escherichia coli IAI39 hypothetical protein YP_002409948.1 4232186 R 585057 CDS YP_002409949.1 218702320 7154141 4233330..4233620 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4233620 yiaG 7154141 yiaG Escherichia coli IAI39 putative transcriptional regulator YP_002409949.1 4233330 D 585057 CDS YP_002409950.1 218702321 7154142 4233901..4234113 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20345064, 90115858, 94293754, 94293756, 99177178, 10696873, 1597410, 1961761, 2404279, 7515185, 8197194, 9405743, 9439003, 9692981; Product type f : factor; major cold shock protein 4234113 cspA 7154142 cspA Escherichia coli IAI39 major cold shock protein YP_002409950.1 4233901 D 585057 CDS YP_002409951.1 218702322 7151012 complement(4234556..4235407) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99350411; Product type h : extrachromosomal origin; IS150 conserved protein InsB 4235407 insK 7151012 insK Escherichia coli IAI39 IS150 conserved protein InsB YP_002409951.1 4234556 R 585057 CDS YP_002409952.1 218702323 7151822 complement(4235404..4235925) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2541046, 2841644; Product type h : extrachromosomal origin; IS150 protein InsA 4235925 insJ 7151822 insJ Escherichia coli IAI39 IS150 protein InsA YP_002409952.1 4235404 R 585057 CDS YP_002409953.1 218702324 7151821 complement(4236224..4238293) 1 NC_011750.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 4238293 glyS 7151821 glyS Escherichia coli IAI39 glycyl-tRNA synthetase subunit beta YP_002409953.1 4236224 R 585057 CDS YP_002409954.1 218702325 7151561 complement(4238303..4239214) 1 NC_011750.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 4239214 glyQ 7151561 glyQ Escherichia coli IAI39 glycyl-tRNA synthetase subunit alpha YP_002409954.1 4238303 R 585057 CDS YP_002409955.1 218702326 7151560 complement(4239309..4239608) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4239608 ysaB 7151560 ysaB Escherichia coli IAI39 hypothetical protein YP_002409955.1 4239309 R 585057 CDS YP_002409956.1 218702327 7154143 complement(4240165..4241055) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 4241055 7154143 ECIAI39_4071 Escherichia coli IAI39 transposase ORF B, IS629 YP_002409956.1 4240165 R 585057 CDS YP_002409957.1 218702328 7150254 complement(4241052..4241378) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 4241378 7150254 ECIAI39_4072 Escherichia coli IAI39 transposase ORF A, IS629 YP_002409957.1 4241052 R 585057 CDS YP_002409958.1 218702329 7154144 complement(4242133..4242570) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4242570 yiaA 7154144 yiaA Escherichia coli IAI39 hypothetical protein YP_002409958.1 4242133 R 585057 CDS YP_002409959.1 218702330 7154138 complement(4243028..4244482) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6330500, 92366447, 95050816, 6320721; Product type e : enzyme; xylulokinase 4244482 xylB 7154138 xylB Escherichia coli IAI39 xylulokinase YP_002409959.1 4243028 R 585057 CDS YP_002409960.1 218702331 7153186 complement(4244554..4245876) 1 NC_011750.1 catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase 4245876 xylA 7153186 xylA Escherichia coli IAI39 xylose isomerase YP_002409960.1 4244554 R 585057 CDS YP_002409961.1 218702332 7153185 4246242..4247234 1 NC_011750.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 4247234 xylF 7153185 xylF Escherichia coli IAI39 D-xylose transporter subunit XylF YP_002409961.1 4246242 D 585057 CDS YP_002409962.1 218702333 7153187 4247312..4248853 1 NC_011750.1 with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit 4248853 xylG 7153187 xylG Escherichia coli IAI39 xylose transporter ATP-binding subunit YP_002409962.1 4247312 D 585057 CDS YP_002409963.1 218702334 7153188 4248831..4250012 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94316500; Product type t : transporter; D-xylose ABC transporter membrane protein 4250012 xylH 7153188 xylH Escherichia coli IAI39 D-xylose ABC transporter membrane protein YP_002409963.1 4248831 D 585057 CDS YP_002409964.1 218702335 7153189 4250090..4251268 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6330500, 94316500; Product type r : regulator; DNA-binding transcriptional activator, xylose-binding 4251268 xylR 7153189 xylR Escherichia coli IAI39 DNA-binding transcriptional activator, xylose-binding YP_002409964.1 4250090 D 585057 CDS YP_002409965.1 218702336 7153190 complement(4251376..4252200) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1544897; hypothetical protein 4252200 bax 7153190 bax Escherichia coli IAI39 hypothetical protein YP_002409965.1 4251376 R 585057 CDS YP_002409966.1 218702337 7150840 4252520..4254550 1 NC_011750.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase 4254550 malS 7150840 malS Escherichia coli IAI39 periplasmic alpha-amylase YP_002409966.1 4252520 D 585057 CDS YP_002409967.1 218702338 7152003 4254728..4255981 1 NC_011750.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 4255981 avtA 7152003 avtA Escherichia coli IAI39 valine--pyruvate transaminase YP_002409967.1 4254728 D 585057 CDS YP_002409968.1 218702339 7150830 complement(4256020..4256493) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative hydrogenase, 4Fe-4S ferredoxin-type component 4256493 yiaI 7150830 yiaI Escherichia coli IAI39 putative hydrogenase, 4Fe-4S ferredoxin-type component YP_002409968.1 4256020 R 585057 CDS YP_002409969.1 218702340 7154145 complement(4256595..4257443) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 20372646, 9826648; Product type r : regulator; DNA-binding transcriptional repressor 4257443 yiaJ 7154145 yiaJ Escherichia coli IAI39 DNA-binding transcriptional repressor YP_002409969.1 4256595 R 585057 CDS YP_002409970.1 218702341 7154146 4257645..4258643 1 NC_011750.1 NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; 2,3-diketo-L-gulonate reductase 4258643 yiaK 7154146 yiaK Escherichia coli IAI39 2,3-diketo-L-gulonate reductase YP_002409970.1 4257645 D 585057 CDS YP_002409971.1 218702342 7154147 4258655..4259122 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21617392; hypothetical protein 4259122 yiaL 7154147 yiaL Escherichia coli IAI39 hypothetical protein YP_002409971.1 4258655 D 585057 CDS YP_002409972.1 218702343 7154148 4259240..4259713 1 NC_011750.1 membrane-spanning protein involved in uptake of 2,3-diketo-L-gulonate; part of the tri-partite ATP-independent periplasmic transport system (TRAP) YiaMNO; 2,3-diketo-L-gulonate TRAP transporter small permease YiaM 4259713 yiaM 7154148 yiaM Escherichia coli IAI39 2,3-diketo-L-gulonate TRAP transporter small permease YiaM YP_002409972.1 4259240 D 585057 CDS YP_002409973.1 218702344 7154149 4259716..4260993 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14668138, 21617392; Product type t : transporter; transporter 4260993 yiaN 7154149 yiaN Escherichia coli IAI39 transporter YP_002409973.1 4259716 D 585057 CDS YP_002409974.1 218702345 7154150 4261006..4261992 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14668138, 21617392; Product type t : transporter; transporter 4261992 yiaO 7154150 yiaO Escherichia coli IAI39 transporter YP_002409974.1 4261006 D 585057 CDS YP_002409975.1 218702346 7154151 4261996..4263492 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21617392, 95050816, 7961955; Product type e : enzyme; L-xylulose kinase 4263492 lyxK 7154151 lyxK Escherichia coli IAI39 L-xylulose kinase YP_002409975.1 4261996 D 585057 CDS YP_002409976.1 218702347 7151988 4263489..4264151 1 NC_011750.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate; 3-keto-L-gulonate-6-phosphate decarboxylase 4264151 sgbH 7151988 sgbH Escherichia coli IAI39 3-keto-L-gulonate-6-phosphate decarboxylase YP_002409976.1 4263489 D 585057 CDS YP_002409977.1 218702348 7152845 4264144..4265004 1 NC_011750.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; putative L-xylulose 5-phosphate 3-epimerase 4265004 sgbU 7152845 sgbU Escherichia coli IAI39 putative L-xylulose 5-phosphate 3-epimerase YP_002409977.1 4264144 D 585057 CDS YP_002409978.1 218702349 7152846 4264998..4265693 1 NC_011750.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4265693 sgbE 7152846 sgbE Escherichia coli IAI39 L-ribulose-5-phosphate 4-epimerase YP_002409978.1 4264998 D 585057 CDS YP_002409979.1 218702350 7152844 complement(4265725..4266540) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator protein 4266540 7152844 ECIAI39_4096 Escherichia coli IAI39 putative transcriptional regulator protein YP_002409979.1 4265725 R 585057 CDS YP_002409980.1 218702351 7150256 4266766..4268166 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease of the major facilitator superfamily 4268166 7150256 ECIAI39_4097 Escherichia coli IAI39 putative permease of the major facilitator superfamily YP_002409980.1 4266766 D 585057 CDS YP_002409981.1 218702352 7150259 complement(4270277..4271017) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4271017 yiaT 7150259 yiaT Escherichia coli IAI39 hypothetical protein YP_002409981.1 4270277 R 585057 CDS YP_002409982.1 218702353 7154152 4271141..4272115 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4272115 yiaU 7154152 yiaU Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002409982.1 4271141 D 585057 CDS YP_002409983.1 218702354 7154153 complement(4272112..4273248) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15668009; Product type t : transporter; membrane fusion protein (MFP) component of efflux pump, signal anchor 4273248 yiaV 7154153 yiaV Escherichia coli IAI39 membrane fusion protein (MFP) component of efflux pump, signal anchor YP_002409983.1 4272112 R 585057 CDS YP_002409984.1 218702355 7154154 complement(4273254..4273577) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4273577 yiaW 7154154 yiaW Escherichia coli IAI39 hypothetical protein YP_002409984.1 4273254 R 585057 CDS YP_002409985.1 218702356 7154155 4273691..4273903 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4273903 7154155 ECIAI39_4104 Escherichia coli IAI39 hypothetical protein YP_002409985.1 4273691 D 585057 CDS YP_002409986.1 218702357 7150260 complement(4274122..4275660) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95286498, 7768815; Product type e : enzyme; aldehyde dehydrogenase B 4275660 aldB 7150260 aldB Escherichia coli IAI39 aldehyde dehydrogenase B YP_002409986.1 4274122 R 585057 CDS YP_002409987.1 218702358 7150712 complement(4275768..4277063) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4277063 7150712 ECIAI39_4106 Escherichia coli IAI39 hypothetical protein YP_002409987.1 4275768 R 585057 CDS YP_002409988.1 218702359 7150261 complement(4277238..4278344) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2935393; Product type e : enzyme; putative alcohol dehydrogenase 4278344 yiaY 7150261 yiaY Escherichia coli IAI39 putative alcohol dehydrogenase YP_002409988.1 4277238 R 585057 CDS YP_002409989.1 218702360 7154156 complement(4278535..4280379) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264431, 91317715, 9315303, 94148228, 2140572, 2531290; Product type f : factor; selenocysteinyl-tRNA-specific translation factor 4280379 selB 7154156 selB Escherichia coli IAI39 selenocysteinyl-tRNA-specific translation factor YP_002409989.1 4278535 R 585057 CDS YP_002409990.1 218702361 7152827 complement(4280376..4281767) 1 NC_011750.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 4281767 selA 7152827 selA Escherichia coli IAI39 selenocysteine synthase YP_002409990.1 4280376 R 585057 CDS YP_002409991.1 218702362 7154159 complement(4282544..4283680) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4283680 yibH 7154159 yibH Escherichia coli IAI39 hypothetical protein YP_002409991.1 4282544 R 585057 CDS YP_002409992.1 218702363 7154160 complement(4283683..4284045) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4284045 yibI 7154160 yibI Escherichia coli IAI39 hypothetical protein YP_002409992.1 4283683 R 585057 CDS YP_002409993.1 218702364 7154161 4284582..4286495 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92052139, 92283796, 94131964, 1946374, 3135464, 3142516, 6309813, 9551558; Product type t : transporter; PTS system mannitol-specific transporter subunit IIABC 4286495 mtlA 7154161 mtlA Escherichia coli IAI39 PTS system mannitol-specific transporter subunit IIABC YP_002409993.1 4284582 D 585057 CDS YP_002409994.1 218702365 7152138 4286590..4287738 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90254197, 1964486, 3135464, 6384188, 8300537, 13295236; Product type e : enzyme; mannitol-1-phosphate 5-dehydrogenase 4287738 mtlD 7152138 mtlD Escherichia coli IAI39 mannitol-1-phosphate 5-dehydrogenase YP_002409994.1 4286590 D 585057 CDS YP_002409995.1 218702366 7152139 4287738..4288325 1 NC_011750.1 Acts as a repressor of the mtlAD operon; mannitol repressor protein 4288325 mtlR 7152139 mtlR Escherichia coli IAI39 mannitol repressor protein YP_002409995.1 4287738 D 585057 CDS YP_002409996.1 218702367 7152140 complement(4288336..4288545) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4288545 yibT 7152140 yibT Escherichia coli IAI39 hypothetical protein YP_002409996.1 4288336 R 585057 CDS YP_002409997.1 218702368 7154166 complement(4288745..4289158) 1 NC_011750.1 hypothetical protein 4289158 7154166 ECIAI39_4118 Escherichia coli IAI39 hypothetical protein YP_002409997.1 4288745 R 585057 CDS YP_002409998.1 218702369 7150262 4288829..4289191 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4289191 yibL 7150262 yibL Escherichia coli IAI39 hypothetical protein YP_002409998.1 4288829 D 585057 CDS YP_002409999.1 218702370 7154163 complement(4289447..4289683) 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 4289683 7154163 ECIAI39_4120 Escherichia coli IAI39 hypothetical protein YP_002409999.1 4289447 R 585057 CDS YP_002410000.1 218702371 7150263 4289749..4290432 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4290432 7150263 ECIAI39_4121 Escherichia coli IAI39 hypothetical protein YP_002410000.1 4289749 D 585057 CDS YP_002410001.1 218702372 7150266 4295643..4297298 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012541, 11283302, 11785976, 8407843; Product type t : transporter; L-lactate permease 4297298 lldP 7150266 lldP Escherichia coli IAI39 L-lactate permease YP_002410001.1 4295643 D 585057 CDS YP_002410002.1 218702373 7151947 4297298..4298074 1 NC_011750.1 represses the lctPRD operon; DNA-binding transcriptional repressor LldR 4298074 lldR 7151947 lldR Escherichia coli IAI39 DNA-binding transcriptional repressor LldR YP_002410002.1 4297298 D 585057 CDS YP_002410003.1 218702374 7151948 4298071..4299261 1 NC_011750.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 4299261 lldD 7151948 lldD Escherichia coli IAI39 L-lactate dehydrogenase YP_002410003.1 4298071 D 585057 CDS YP_002410004.1 218702375 7151946 4299334..4299807 1 NC_011750.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; putative tRNA/rRNA methyltransferase YibK 4299807 yibK 7151946 yibK Escherichia coli IAI39 putative tRNA/rRNA methyltransferase YibK YP_002410004.1 4299334 D 585057 CDS YP_002410005.1 218702376 7154162 complement(4299860..4300681) 1 NC_011750.1 catalyzes the O-acetylation of serine; serine acetyltransferase 4300681 cysE 7154162 cysE Escherichia coli IAI39 serine acetyltransferase YP_002410005.1 4299860 R 585057 CDS YP_002410006.1 218702377 7151059 complement(4300761..4301780) 1 NC_011750.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 4301780 gpsA 7151059 gpsA Escherichia coli IAI39 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_002410006.1 4300761 R 585057 CDS YP_002410007.1 218702378 7151581 complement(4301780..4302247) 1 NC_011750.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 4302247 secB 7151581 secB Escherichia coli IAI39 preprotein translocase subunit SecB YP_002410007.1 4301780 R 585057 CDS YP_002410008.1 218702379 7152819 complement(4302310..4302561) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94316500, 95024051, 99175138, 11031118, 7937896, 8636094, 9973569; Product type c : carrier; glutaredoxin 3 4302561 grxC 7152819 grxC Escherichia coli IAI39 glutaredoxin 3 YP_002410008.1 4302310 R 585057 CDS YP_002410009.1 218702380 7151590 complement(4302703..4303134) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative rhodanese-related sulfurtransferase 4303134 yibN 7151590 yibN Escherichia coli IAI39 putative rhodanese-related sulfurtransferase YP_002410009.1 4302703 R 585057 CDS YP_002410010.1 218702381 7154164 4303379..4304923 1 NC_011750.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 4304923 gpmI 7154164 gpmI Escherichia coli IAI39 phosphoglyceromutase YP_002410010.1 4303379 D 585057 CDS YP_002410011.1 218702382 7151579 4304957..4306216 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12113939, 21972773; Product type cp : cell process; hypothetical protein 4306216 envC 7151579 envC Escherichia coli IAI39 hypothetical protein YP_002410011.1 4304957 D 585057 CDS YP_002410012.1 218702383 7151228 4306220..4307179 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative polysaccharide deacetylase 4307179 yibQ 7151228 yibQ Escherichia coli IAI39 putative polysaccharide deacetylase YP_002410012.1 4306220 D 585057 CDS YP_002410013.1 218702384 7154165 complement(4307166..4308200) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15659689, 2647748; Product type pe : putative enzyme; putative glycosyl transferase 4308200 yibD 7154165 yibD Escherichia coli IAI39 putative glycosyl transferase YP_002410013.1 4307166 R 585057 CDS YP_002410014.1 218702385 7154157 complement(4308439..4309464) 1 NC_011750.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 4309464 tdh 7154157 tdh Escherichia coli IAI39 L-threonine 3-dehydrogenase YP_002410014.1 4308439 R 585057 CDS YP_002410015.1 218702386 7152961 complement(4309474..4310670) 1 NC_011750.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase 4310670 kbl 7152961 kbl Escherichia coli IAI39 2-amino-3-ketobutyrate coenzyme A ligase YP_002410015.1 4309474 R 585057 CDS YP_002410016.1 218702387 7151875 4310884..4311816 1 NC_011750.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-mannoheptose-6-epimerase 4311816 rfaD 7151875 rfaD Escherichia coli IAI39 ADP-L-glycero-D-mannoheptose-6-epimerase YP_002410016.1 4310884 D 585057 CDS YP_002410017.1 218702388 7153135 4311826..4312872 1 NC_011750.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose:LPS heptosyltransferase II 4312872 waaF 7153135 waaF Escherichia coli IAI39 ADP-heptose:LPS heptosyltransferase II YP_002410017.1 4311826 D 585057 CDS YP_002410018.1 218702389 7153136 4312876..4313847 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20507564, 92250420, 93239678, 9446588, 1624462, 8478319; Product type e : enzyme; ADP-heptose:LPS heptosyl transferase I 4313847 waaC 7153136 waaC Escherichia coli IAI39 ADP-heptose:LPS heptosyl transferase I YP_002410018.1 4312876 D 585057 CDS YP_002410019.1 218702390 7153134 complement(4313917..4315170) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92250420, 92325067, 93054344, 1624462; Product type e : enzyme; lipid A-core surface O-antigen ligase 4315170 waaL 7153134 waaL Escherichia coli IAI39 lipid A-core surface O-antigen ligase YP_002410019.1 4313917 R 585057 CDS YP_002410020.1 218702391 7153138 complement(4315216..4316199) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative beta1,3-glucosyltransferase 4316199 waaV 7153138 waaV Escherichia coli IAI39 putative beta1,3-glucosyltransferase YP_002410020.1 4315216 R 585057 CDS YP_002410021.1 218702392 7153143 complement(4316278..4317306) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9791168, 9756860, 9792656; Product type e : enzyme; UDP-galactose:(Galactosyl) LPS alpha1, 2-galactosyltransferase 4317306 waaW 7153143 waaW Escherichia coli IAI39 UDP-galactose:(Galactosyl) LPS alpha1, 2-galactosyltransferase YP_002410021.1 4316278 R 585057 CDS YP_002410022.1 218702393 7153144 complement(4317332..4318024) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92250420, 92325067, 9756860; Product type e : enzyme; lipopolysaccharide core biosynthesis protein 4318024 waaY 7153144 waaY Escherichia coli IAI39 lipopolysaccharide core biosynthesis protein YP_002410022.1 4317332 R 585057 CDS YP_002410023.1 218702394 7153145 complement(4318034..4319029) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9791168, 9756860, 9792656; Product type e : enzyme; UDP-galactose:(Glucosyl) LPS alpha1, 2-galactosyltransferase 4319029 waaT 7153145 waaT Escherichia coli IAI39 UDP-galactose:(Glucosyl) LPS alpha1, 2-galactosyltransferase YP_002410023.1 4318034 R 585057 CDS YP_002410024.1 218702395 7153142 complement(4319046..4320062) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme; UDP-glucose:(Glucosyl) LPS alpha1, 3-glucosyltransferase 4320062 waaO 7153142 waaO Escherichia coli IAI39 UDP-glucose:(Glucosyl) LPS alpha1, 3-glucosyltransferase YP_002410024.1 4319046 R 585057 CDS YP_002410025.1 218702396 7153139 complement(4320078..4320884) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101922, 92121133, 92210496, 9756860, 1732225; Product type e : enzyme; kinase that phosphorylates core heptose of lipopolysaccharide 4320884 waaP 7153139 waaP Escherichia coli IAI39 kinase that phosphorylates core heptose of lipopolysaccharide YP_002410025.1 4320078 R 585057 CDS YP_002410026.1 218702397 7153140 complement(4320868..4321992) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92121133, 92210496, 92250420, 1447141, 1732225, 7988890; Product type e : enzyme; glucosyltransferase I 4321992 waaG 7153140 waaG Escherichia coli IAI39 glucosyltransferase I YP_002410026.1 4320868 R 585057 CDS YP_002410027.1 218702398 7153137 complement(4321989..4323047) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9756860, 1447141, 1732225; Product type e : enzyme; lipopolysaccharide core biosynthesis protein 4323047 waaQ 7153137 waaQ Escherichia coli IAI39 lipopolysaccharide core biosynthesis protein YP_002410027.1 4321989 R 585057 CDS YP_002410028.1 218702399 7153141 4323460..4324737 1 NC_011750.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 4324737 kdtA 7153141 kdtA Escherichia coli IAI39 3-deoxy-D-manno-octulosonic-acid transferase YP_002410028.1 4323460 D 585057 CDS YP_002410029.1 218702400 7151889 4324745..4325224 1 NC_011750.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 4325224 coaD 7151889 coaD Escherichia coli IAI39 phosphopantetheine adenylyltransferase YP_002410029.1 4324745 D 585057 CDS YP_002410030.1 218702401 7150974 complement(4325263..4326072) 1 NC_011750.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 4326072 mutM 7150974 mutM Escherichia coli IAI39 formamidopyrimidine-DNA glycosylase YP_002410030.1 4325263 R 585057 CDS YP_002410031.1 218702402 7152157 complement(4326170..4326337) 1 NC_011750.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 4326337 rpmG 7152157 rpmG Escherichia coli IAI39 50S ribosomal protein L33 YP_002410031.1 4326170 R 585057 CDS YP_002410032.1 218702403 7152700 complement(4326358..4326594) 1 NC_011750.1 required for 70S ribosome assembly; 50S ribosomal protein L28 4326594 rpmB 7152700 rpmB Escherichia coli IAI39 50S ribosomal protein L28 YP_002410032.1 4326358 R 585057 CDS YP_002410033.1 218702404 7152695 complement(4326811..4327479) 1 NC_011750.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 4327479 radC 7152695 radC Escherichia coli IAI39 DNA repair protein RadC YP_002410033.1 4326811 R 585057 CDS YP_002410034.1 218702405 7154177 4327651..4328871 1 NC_011750.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 4328871 dfp 7154177 dfp Escherichia coli IAI39 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_002410034.1 4327651 D 585057 CDS YP_002410035.1 218702406 7151124 4328852..4329307 1 NC_011750.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 4329307 dut 7151124 dut Escherichia coli IAI39 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_002410035.1 4328852 D 585057 CDS YP_002410036.1 218702407 7151188 4329414..4330010 1 NC_011750.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 4330010 slmA 7151188 slmA Escherichia coli IAI39 nucleoid occlusion protein YP_002410036.1 4329414 D 585057 CDS YP_002410037.1 218702408 7153053 complement(4329863..4331026) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2466573; Product type pe : putative enzyme; putative retron-type reverse transcriptase 4331026 7153053 ECIAI39_4160 Escherichia coli IAI39 putative retron-type reverse transcriptase YP_002410037.1 4329863 R 585057 CDS YP_002410038.1 218702409 7150267 complement(4331312..4331953) 1 NC_011750.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 4331953 pyrE 7150267 pyrE Escherichia coli IAI39 orotate phosphoribosyltransferase YP_002410038.1 4331312 R 585057 CDS YP_002410039.1 218702410 7152551 complement(4332019..4332759) 1 NC_011750.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 4332759 rph 7152551 rph Escherichia coli IAI39 ribonuclease PH YP_002410039.1 4332019 R 585057 CDS YP_002410040.1 218702411 7152667 4332862..4333725 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4333725 yicC 7152667 yicC Escherichia coli IAI39 hypothetical protein YP_002410040.1 4332862 D 585057 CDS YP_002410041.1 218702412 7154167 4333997..4334515 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4334515 7154167 ECIAI39_4164 Escherichia coli IAI39 hypothetical protein YP_002410041.1 4333997 D 585057 CDS YP_002410042.1 218702413 7150268 4334534..4335754 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase 4335754 7150268 ECIAI39_4165 Escherichia coli IAI39 putative transposase YP_002410042.1 4334534 D 585057 CDS YP_002410043.1 218702414 7150269 4335828..4336664 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 913680, 94334998, 95095962, 1925027, 2158980, 2664418, 8002613, 8057377, 8195095; Product type cp : cell process; DNA-damage-inducible protein D 4336664 dinD 7150269 dinD Escherichia coli IAI39 DNA-damage-inducible protein D YP_002410043.1 4335828 D 585057 CDS YP_002410044.1 218702415 7151138 4336956..4337573 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4337573 yicG 7151138 yicG Escherichia coli IAI39 hypothetical protein YP_002410044.1 4336956 D 585057 CDS YP_002410045.1 218702416 7154169 complement(4337570..4339252) 1 NC_011750.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB 4339252 ligB 7154169 ligB Escherichia coli IAI39 NAD-dependent DNA ligase LigB YP_002410045.1 4337570 R 585057 CDS YP_002410046.1 218702417 7151936 4339510..4340133 1 NC_011750.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 4340133 gmk 7151936 gmk Escherichia coli IAI39 guanylate kinase YP_002410046.1 4339510 D 585057 CDS YP_002410047.1 218702418 7151564 4340188..4340463 1 NC_011750.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 4340463 rpoZ 7151564 rpoZ Escherichia coli IAI39 DNA-directed RNA polymerase subunit omega YP_002410047.1 4340188 D 585057 CDS YP_002410048.1 218702419 7152711 4340482..4342590 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12224635, 89255395, 93266525, 94068533, 2005134, 2549050; Product type e : enzyme; bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 4342590 spoT 7152711 spoT Escherichia coli IAI39 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase YP_002410048.1 4340482 D 585057 CDS YP_002410049.1 218702420 7152887 4342597..4343286 1 NC_011750.1 specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 4343286 trmH 7152887 trmH Escherichia coli IAI39 tRNA guanosine-2'-O-methyltransferase YP_002410049.1 4342597 D 585057 CDS YP_002410050.1 218702421 7153029 4343292..4345373 1 NC_011750.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 4345373 recG 7153029 recG Escherichia coli IAI39 ATP-dependent DNA helicase RecG YP_002410050.1 4343292 D 585057 CDS YP_002410051.1 218702422 7152592 complement(4345407..4346612) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91203811, 93106943, 1544582, 2017136, 2254324; Product type t : transporter; glutamate transporter 4346612 gltS 7152592 gltS Escherichia coli IAI39 glutamate transporter YP_002410051.1 4345407 R 585057 CDS YP_002410052.1 218702423 7151556 4346892..4348283 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4348283 yicE 7151556 yicE Escherichia coli IAI39 putative transporter YP_002410052.1 4346892 D 585057 CDS YP_002410053.1 218702424 7154168 4348404..4350113 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4350113 yicH 7154168 yicH Escherichia coli IAI39 hypothetical protein YP_002410053.1 4348404 D 585057 CDS YP_002410054.1 218702425 7154170 complement(4350156..4350875) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative regulatory protein 4350875 7154170 ECIAI39_4178 Escherichia coli IAI39 putative regulatory protein YP_002410054.1 4350156 R 585057 CDS YP_002410055.1 218702426 7150270 complement(4350817..4351782) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar kinase/transcriptional regulator. ATPase domain 4351782 7150270 ECIAI39_4179 Escherichia coli IAI39 putative sugar kinase/transcriptional regulator. ATPase domain YP_002410055.1 4350817 R 585057 CDS YP_002410056.1 218702427 7150271 complement(4351797..4352657) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 4352657 7150271 ECIAI39_4180 Escherichia coli IAI39 hypothetical protein YP_002410056.1 4351797 R 585057 CDS YP_002410057.1 218702428 7150272 complement(4352738..4353589) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar aldolase 4353589 7150272 ECIAI39_4181 Escherichia coli IAI39 putative sugar aldolase YP_002410057.1 4352738 R 585057 CDS YP_002410058.1 218702429 7150273 complement(4353601..4354692) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative phosphotransferase system, fructose-specific IIC component 4354692 7150273 ECIAI39_4182 Escherichia coli IAI39 putative phosphotransferase system, fructose-specific IIC component YP_002410058.1 4353601 R 585057 CDS YP_002410059.1 218702430 7150274 complement(4354717..4355031) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative phosphotransferase system, fructose-specific IIB subunit 4355031 7150274 ECIAI39_4183 Escherichia coli IAI39 putative phosphotransferase system, fructose-specific IIB subunit YP_002410059.1 4354717 R 585057 CDS YP_002410060.1 218702431 7150275 complement(4355049..4355519) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative phosphotransferase system (PTS), fructose-specific IIA component 4355519 7150275 ECIAI39_4184 Escherichia coli IAI39 putative phosphotransferase system (PTS), fructose-specific IIA component YP_002410060.1 4355049 R 585057 CDS YP_002410061.1 218702432 7150276 complement(4355546..4357099) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative PTS system transcriptional antiterminator 4357099 7150276 ECIAI39_4185 Escherichia coli IAI39 putative PTS system transcriptional antiterminator YP_002410061.1 4355546 R 585057 CDS YP_002410062.1 218702433 7150277 complement(4357394..4359712) 1 NC_011750.1 catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase YicI 4359712 yicI 7150277 yicI Escherichia coli IAI39 alpha-xylosidase YicI YP_002410062.1 4357394 R 585057 CDS YP_002410063.1 218702434 7154171 complement(4359722..4361104) 1 NC_011750.1 may be involved in the transport of galactosides-pentoses-hexuronides; putative transporter 4361104 yicJ 7154171 yicJ Escherichia coli IAI39 putative transporter YP_002410063.1 4359722 R 585057 CDS YP_002410064.1 218702435 7150572 4361791..4362975 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative prophage integrase 4362975 7150572 ECIAI39_4188 Escherichia coli IAI39 putative prophage integrase YP_002410064.1 4361791 D 585057 CDS YP_002410065.1 218702436 7150278 4362996..4363151 1 NC_011750.1 hypothetical protein 4363151 7150278 ECIAI39_4189 Escherichia coli IAI39 hypothetical protein YP_002410065.1 4362996 D 585057 CDS YP_002410066.1 218702437 7150279 4363387..4364430 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411725; Product type pe : putative enzyme; SHI-2 pathogenicity island protein 4364430 7150279 ECIAI39_4190 Escherichia coli IAI39 SHI-2 pathogenicity island protein YP_002410066.1 4363387 D 585057 CDS YP_002410067.1 218702438 7150280 complement(4364781..4366283) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated, metal-dependent hydrolase 4366283 7150280 ECIAI39_4191 Escherichia coli IAI39 putative membrane-associated, metal-dependent hydrolase YP_002410067.1 4364781 R 585057 CDS YP_002410068.1 218702439 7150281 complement(4366458..4367213) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8675335, 16369033; Product type f : factor; Tia invasion determinant 4367213 tia 7150281 tia Escherichia coli IAI39 Tia invasion determinant YP_002410068.1 4366458 R 585057 CDS YP_002410069.1 218702440 7152983 4367382..4367612 1 NC_011750.1 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; putative Prophage integrase (fragment) 4367612 7152983 ECIAI39_4193 Escherichia coli IAI39 putative Prophage integrase (fragment) YP_002410069.1 4367382 D 585057 CDS YP_002410070.1 218702441 7150282 4367761..4368159 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4368159 7150282 ECIAI39_4194 Escherichia coli IAI39 hypothetical protein YP_002410070.1 4367761 D 585057 CDS YP_002410071.1 218702442 7150283 complement(4369119..4370618) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Na+/H+ antiporter 4370618 7150283 ECIAI39_4195 Escherichia coli IAI39 putative Na+/H+ antiporter YP_002410071.1 4369119 R 585057 CDS YP_002410072.1 218702443 7150284 complement(4370563..4371855) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Aspartate transaminase 4371855 7150284 ECIAI39_4196 Escherichia coli IAI39 putative Aspartate transaminase YP_002410072.1 4370563 R 585057 CDS YP_002410073.1 218702444 7150285 4372215..4372541 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 4372541 7150285 ECIAI39_4197 Escherichia coli IAI39 transposase ORF A, IS629 YP_002410073.1 4372215 D 585057 CDS YP_002410074.1 218702445 7150286 4372538..4373020 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 4373020 7150286 ECIAI39_4198 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002410074.1 4372538 D 585057 CDS YP_002410075.1 218702446 7150287 4373612..4375135 1 NC_011750.1 Group II intron-encoded reverse transcriptase/maturase 4375135 7150287 ECIAI39_4199 Escherichia coli IAI39 Group II intron-encoded reverse transcriptase/maturase YP_002410075.1 4373612 D 585057 CDS YP_002410076.1 218702447 7150548 4375252..4375698 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 4375698 7150548 ECIAI39_4200 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002410076.1 4375252 D 585057 CDS YP_002410077.1 218702448 7150289 4375988..4376566 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative transcriptional regulator 4376566 7150289 ECIAI39_4201 Escherichia coli IAI39 putative transcriptional regulator YP_002410077.1 4375988 D 585057 CDS YP_002410078.1 218702449 7150290 4376589..4377407 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative transcriptionnal regulator 4377407 7150290 ECIAI39_4202 Escherichia coli IAI39 putative transcriptionnal regulator YP_002410078.1 4376589 D 585057 CDS YP_002410079.1 218702450 7150291 4377395..4377925 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4377925 7150291 ECIAI39_4203 Escherichia coli IAI39 hypothetical protein YP_002410079.1 4377395 D 585057 CDS YP_002410080.1 218702451 7150292 complement(4377922..4378086) 1 NC_011750.1 hypothetical protein 4378086 7150292 ECIAI39_4204 Escherichia coli IAI39 hypothetical protein YP_002410080.1 4377922 R 585057 CDS YP_002410081.1 218702452 7150293 4378394..4378723 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10768928, 9370271, 9573168, 11964144, 4295288; Product type ps : putative structure; putative propanediol utilization protein PduJ/pduA 4378723 7150293 ECIAI39_4205 Escherichia coli IAI39 putative propanediol utilization protein PduJ/pduA YP_002410081.1 4378394 D 585057 CDS YP_002410082.1 218702453 7150294 4378741..4379025 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12007656, 8071226, 9352910, 10498708; Product type ps : putative structure; putative Propanediol utilization protein pduA/pduJ 4379025 7150294 ECIAI39_4206 Escherichia coli IAI39 putative Propanediol utilization protein pduA/pduJ YP_002410082.1 4378741 D 585057 CDS YP_002410083.1 218702454 7150295 4379040..4379318 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8071226, 9352910, 10498708; Product type ps : putative structure; putative propanediol utilization protein: polyhedral bodies pduJ or pduA 4379318 7150295 ECIAI39_4207 Escherichia coli IAI39 putative propanediol utilization protein: polyhedral bodies pduJ or pduA YP_002410083.1 4379040 D 585057 CDS YP_002410084.1 218702455 7150686 4380985..4381242 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative ethanolamine utilization protein EutN/carboxysome structural protein Ccml 4381242 7150686 ECIAI39_4209 Escherichia coli IAI39 putative ethanolamine utilization protein EutN/carboxysome structural protein Ccml YP_002410084.1 4380985 D 585057 CDS YP_002410085.1 218702456 7150687 4382403..4385825 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Formate C-acetyltransferase (Pyruvate formate-lyase) 4385825 7150687 ECIAI39_4211 Escherichia coli IAI39 putative Formate C-acetyltransferase (Pyruvate formate-lyase) YP_002410085.1 4382403 D 585057 CDS YP_002410086.1 218702457 7150298 4385877..4386824 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative pyruvate formate-lyase activating enzyme 4386824 7150298 ECIAI39_4212 Escherichia coli IAI39 putative pyruvate formate-lyase activating enzyme YP_002410086.1 4385877 D 585057 CDS YP_002410087.1 218702458 7150299 4386836..4387300 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative microcompartments protein 4387300 7150299 ECIAI39_4213 Escherichia coli IAI39 putative microcompartments protein YP_002410087.1 4386836 D 585057 CDS YP_002410088.1 218702459 7150300 4387297..4387917 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4387917 7150300 ECIAI39_4214 Escherichia coli IAI39 hypothetical protein YP_002410088.1 4387297 D 585057 CDS YP_002410089.1 218702460 7150301 4387929..4388594 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4388594 7150301 ECIAI39_4215 Escherichia coli IAI39 hypothetical protein YP_002410089.1 4387929 D 585057 CDS YP_002410090.1 218702461 7150302 4388627..4389028 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative membrane transport protein 4389028 7150302 ECIAI39_4216 Escherichia coli IAI39 putative membrane transport protein YP_002410090.1 4388627 D 585057 CDS YP_002410091.1 218702462 7150303 4389038..4389373 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative multidrug resistance protein 4389373 7150303 ECIAI39_4217 Escherichia coli IAI39 putative multidrug resistance protein YP_002410091.1 4389038 D 585057 CDS YP_002410092.1 218702463 7150304 complement(4389597..4389929) 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 4389929 7150304 ECIAI39_4218 Escherichia coli IAI39 transposase ORF B (fragment), IS629 YP_002410092.1 4389597 R 585057 CDS YP_002410093.1 218702464 7150305 complement(4390023..4390973) 1 NC_011750.1 regulates the synthesis and expression of the dsdXA operon and dadA gene; DNA-binding transcriptional regulator DsdC 4390973 dsdC 7150305 dsdC Escherichia coli IAI39 DNA-binding transcriptional regulator DsdC YP_002410093.1 4390023 R 585057 CDS YP_002410094.1 218702465 7151179 4391185..4392522 1 NC_011750.1 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; permease DsdX 4392522 dsdX 7151179 dsdX Escherichia coli IAI39 permease DsdX YP_002410094.1 4391185 D 585057 CDS YP_002410095.1 218702466 7151181 4392540..4393871 1 NC_011750.1 catalyzes the formation of pyruvate from serine; D-serine dehydratase 4393871 dsdA 7151181 dsdA Escherichia coli IAI39 D-serine dehydratase YP_002410095.1 4392540 D 585057 CDS YP_002410096.1 218702467 7151177 complement(4394142..4394378) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative phage regulatory protein 4394378 7151177 ECIAI39_4222 Escherichia coli IAI39 putative phage regulatory protein YP_002410096.1 4394142 R 585057 CDS YP_002410097.1 218702468 7150306 complement(4394447..4395049) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4395049 7150306 ECIAI39_4223 Escherichia coli IAI39 hypothetical protein YP_002410097.1 4394447 R 585057 CDS YP_002410098.1 218702469 7150307 complement(4395277..4395843) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4395843 7150307 ECIAI39_4224 Escherichia coli IAI39 hypothetical protein YP_002410098.1 4395277 R 585057 CDS YP_002410099.1 218702470 7150308 complement(4396663..4396749) 1 NC_011750.1 hypothetical protein 4396749 7150308 ECIAI39_4225 Escherichia coli IAI39 hypothetical protein YP_002410099.1 4396663 R 585057 CDS YP_002410100.1 218702471 7150309 4397180..4398274 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 4398274 7150309 ECIAI39_4226 Escherichia coli IAI39 hypothetical protein YP_002410100.1 4397180 D 585057 CDS YP_002410101.1 218702472 7150310 complement(4398293..4399543) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sodium/proton nucleoside transporter 4399543 yeiM 7150310 yeiM Escherichia coli IAI39 putative sodium/proton nucleoside transporter YP_002410101.1 4398293 R 585057 CDS YP_002410102.1 218702473 7153776 complement(4399627..4400562) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4400562 yeiN 7153776 yeiN Escherichia coli IAI39 hypothetical protein YP_002410102.1 4399627 R 585057 CDS YP_002410103.1 218702474 7153778 complement(4400555..4401517) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 4401517 7153778 ECIAI39_4229 Escherichia coli IAI39 hypothetical protein YP_002410103.1 4400555 R 585057 CDS YP_002410104.1 218702475 7150311 complement(4402026..4402478) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hexapeptide repeat acetyltransferase 4402478 7150311 ECIAI39_4230 Escherichia coli IAI39 putative hexapeptide repeat acetyltransferase YP_002410104.1 4402026 R 585057 CDS YP_002410105.1 218702476 7150312 complement(4402521..4402706) 1 NC_011750.1 hypothetical protein 4402706 7150312 ECIAI39_4231 Escherichia coli IAI39 hypothetical protein YP_002410105.1 4402521 R 585057 CDS YP_002410106.1 218702477 7150313 complement(4402999..4403730) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4403730 7150313 ECIAI39_4232 Escherichia coli IAI39 hypothetical protein YP_002410106.1 4402999 R 585057 CDS YP_002410107.1 218702478 7150314 4404400..4404930 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4404930 7150314 ECIAI39_4233 Escherichia coli IAI39 hypothetical protein YP_002410107.1 4404400 D 585057 CDS YP_002410108.1 218702479 7150315 complement(4405966..4406148) 1 NC_011750.1 hypothetical protein 4406148 7150315 ECIAI39_4234 Escherichia coli IAI39 hypothetical protein YP_002410108.1 4405966 R 585057 CDS YP_002410109.1 218702480 7150316 complement(4406093..4407316) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4407316 7150316 ECIAI39_4235 Escherichia coli IAI39 hypothetical protein YP_002410109.1 4406093 R 585057 CDS YP_002410110.1 218702481 7150317 4407417..4408301 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative GTPase 4408301 7150317 ECIAI39_4236 Escherichia coli IAI39 putative GTPase YP_002410110.1 4407417 D 585057 CDS YP_002410111.1 218702482 7150318 4409227..4410012 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4410012 7150318 ECIAI39_4237 Escherichia coli IAI39 hypothetical protein YP_002410111.1 4409227 D 585057 CDS YP_002410112.1 218702483 7150319 4410018..4410251 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4410251 7150319 ECIAI39_4238 Escherichia coli IAI39 hypothetical protein YP_002410112.1 4410018 D 585057 CDS YP_002410113.1 218702484 7150320 4410341..4411159 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4411159 7150320 ECIAI39_4239 Escherichia coli IAI39 hypothetical protein YP_002410113.1 4410341 D 585057 CDS YP_002410114.1 218702485 7150321 4411353..4411904 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative antirestriction protein 4411904 7150321 ECIAI39_4240 Escherichia coli IAI39 putative antirestriction protein YP_002410114.1 4411353 D 585057 CDS YP_002410115.1 218702486 7150322 4411905..4412396 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : putative factor; putative DNA repair protein; CP4-44 prophage 4412396 yeeS 7150322 yeeS Escherichia coli IAI39 putative DNA repair protein; CP4-44 prophage YP_002410115.1 4411905 D 585057 CDS YP_002410116.1 218702487 7153716 4412483..4412704 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 4412704 yeeT 7153716 yeeT Escherichia coli IAI39 hypothetical protein YP_002410116.1 4412483 D 585057 CDS YP_002410117.1 218702488 7153719 4412784..4413152 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin 4413152 yeeU 7153719 yeeU Escherichia coli IAI39 CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin YP_002410117.1 4412784 D 585057 CDS YP_002410118.1 218702489 7153722 4413241..4413618 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; toxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage 4413618 yeeV 7153722 yeeV Escherichia coli IAI39 toxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage YP_002410118.1 4413241 D 585057 CDS YP_002410119.1 218702490 7153725 4413615..4414037 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4414037 yeeW 7153725 yeeW Escherichia coli IAI39 hypothetical protein YP_002410119.1 4413615 D 585057 CDS YP_002410120.1 218702491 7153728 4414122..4414964 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9987116; hypothetical protein 4414964 7153728 ECIAI39_4246 Escherichia coli IAI39 hypothetical protein YP_002410120.1 4414122 D 585057 CDS YP_002410121.1 218702492 7150323 4415228..4415371 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 4415371 7150323 ECIAI39_4247 Escherichia coli IAI39 hypothetical protein YP_002410121.1 4415228 D 585057 CDS YP_002410122.1 218702493 7150324 4415758..4416942 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10438463, 10209755; Product type pt : putative transporter; putative sugar efflux system 4416942 setC 7150324 setC Escherichia coli IAI39 putative sugar efflux system YP_002410122.1 4415758 D 585057 CDS YP_002410123.1 218702494 7152835 4417053..4417976 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4417976 yicL 7152835 yicL Escherichia coli IAI39 hypothetical protein YP_002410123.1 4417053 D 585057 CDS YP_002410124.1 218702495 7154173 complement(4417980..4418798) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88298691, 89359178, 9914480, 3003106; Product type lp : lipoprotein; cytoplasmic membrane lipoprotein-28 4418798 nlpA 7154173 nlpA Escherichia coli IAI39 cytoplasmic membrane lipoprotein-28 YP_002410124.1 4417980 R 585057 CDS YP_002410125.1 218702496 7152233 4418937..4419299 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4419299 yicS 7152233 yicS Escherichia coli IAI39 hypothetical protein YP_002410125.1 4418937 D 585057 CDS YP_002410126.1 218702497 7154178 4419601..4420098 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative type III secretion chaperone 4420098 7154178 ECIAI39_4252 Escherichia coli IAI39 putative type III secretion chaperone YP_002410126.1 4419601 D 585057 CDS YP_002410127.1 218702498 7150325 4420346..4422127 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4422127 7150325 ECIAI39_4254 Escherichia coli IAI39 hypothetical protein YP_002410127.1 4420346 D 585057 CDS YP_002410128.1 218702499 7150326 4422140..4423291 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4423291 7150326 ECIAI39_4255 Escherichia coli IAI39 hypothetical protein YP_002410128.1 4422140 D 585057 CDS YP_002410129.1 218702500 7150327 4423335..4424684 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4424684 7150327 ECIAI39_4256 Escherichia coli IAI39 hypothetical protein YP_002410129.1 4423335 D 585057 CDS YP_002410130.1 218702501 7150328 4424887..4426584 1 NC_011750.1 Activates the expression of invasion genes and activates the expression of prgHIJK which is part of the pathogenicity island 1 type III secretion system; invasion protein regulator 4426584 7150328 ECIAI39_4257 Escherichia coli IAI39 invasion protein regulator YP_002410130.1 4424887 D 585057 CDS YP_002410131.1 218702502 7150329 complement(4426636..4435146) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative invasin/intimin protein 4435146 7150329 ECIAI39_4258 Escherichia coli IAI39 putative invasin/intimin protein YP_002410131.1 4426636 R 585057 CDS YP_002410132.1 218702503 7150330 complement(4435348..4436580) 1 NC_011750.1 experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter 4436580 nepI 7150330 nepI Escherichia coli IAI39 ribonucleoside transporter YP_002410132.1 4435348 R 585057 CDS YP_002410133.1 218702504 7154174 complement(4436616..4436807) 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 4436807 7154174 ECIAI39_4260 Escherichia coli IAI39 hypothetical protein YP_002410133.1 4436616 R 585057 CDS YP_002410134.1 218702505 7150331 4436811..4437089 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4437089 7150331 ECIAI39_4261 Escherichia coli IAI39 hypothetical protein YP_002410134.1 4436811 D 585057 CDS YP_002410135.1 218702506 7150332 4437102..4437425 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative transcriptional regulator 4437425 7150332 ECIAI39_4262 Escherichia coli IAI39 putative transcriptional regulator YP_002410135.1 4437102 D 585057 CDS YP_002410136.1 218702507 7150333 complement(4437541..4437993) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4437993 yicN 7150333 yicN Escherichia coli IAI39 hypothetical protein YP_002410136.1 4437541 R 585057 CDS YP_002410137.1 218702508 7154175 complement(4438046..4439380) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative xanthine/uracil permease 4439380 yicO 7154175 yicO Escherichia coli IAI39 putative xanthine/uracil permease YP_002410137.1 4438046 R 585057 CDS YP_002410138.1 218702509 7154176 4439555..4441321 1 NC_011750.1 catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 4441321 ade 7154176 ade Escherichia coli IAI39 cryptic adenine deaminase YP_002410138.1 4439555 D 585057 CDS YP_002410139.1 218702510 7150684 complement(4441368..4442759) 1 NC_011750.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter 4442759 uhpT 7150684 uhpT Escherichia coli IAI39 sugar phosphate antiporter YP_002410139.1 4441368 R 585057 CDS YP_002410140.1 218702511 7153089 complement(4442897..4444216) 1 NC_011750.1 membrane protein regulates uhpT expression; regulatory protein UhpC 4444216 uhpC 7153089 uhpC Escherichia coli IAI39 regulatory protein UhpC YP_002410140.1 4442897 R 585057 CDS YP_002410141.1 218702512 7153088 complement(4444226..4445728) 1 NC_011750.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB 4445728 uhpB 7153088 uhpB Escherichia coli IAI39 sensory histidine kinase UhpB YP_002410141.1 4444226 R 585057 CDS YP_002410142.1 218702513 7153087 complement(4445728..4446318) 1 NC_011750.1 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; DNA-binding transcriptional activator UhpA 4446318 uhpA 7153087 uhpA Escherichia coli IAI39 DNA-binding transcriptional activator UhpA YP_002410142.1 4445728 R 585057 CDS YP_002410143.1 218702514 7153086 complement(4446480..4447982) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4447982 7153086 ECIAI39_4270 Escherichia coli IAI39 hypothetical protein YP_002410143.1 4446480 R 585057 CDS YP_002410144.1 218702515 7150334 complement(4448197..4449492) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4449492 7150334 ECIAI39_4271 Escherichia coli IAI39 hypothetical protein YP_002410144.1 4448197 R 585057 CDS YP_002410145.1 218702516 7150335 complement(4449743..4450033) 1 NC_011750.1 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit 4450033 ilvN 7150335 ilvN Escherichia coli IAI39 acetolactate synthase 1 regulatory subunit YP_002410145.1 4449743 R 585057 CDS YP_002410146.1 218702517 7151773 complement(4450037..4451725) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2989782, 85242083, 92380929, 2989781; Product type e : enzyme; acetolactate synthase catalytic subunit 4451725 ilvB 7151773 ilvB Escherichia coli IAI39 acetolactate synthase catalytic subunit YP_002410146.1 4450037 R 585057 CDS YP_002410147.1 218702518 7151764 4451709..4452206 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 4452206 7151764 ECIAI39_4274 Escherichia coli IAI39 hypothetical protein YP_002410147.1 4451709 D 585057 CDS YP_002410148.1 218702519 7150336 complement(4451831..4451929) 1 NC_011750.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; ilvB operon leader peptide 4451929 ivbL 7150336 ivbL Escherichia coli IAI39 ilvB operon leader peptide YP_002410148.1 4451831 R 585057 CDS YP_002410149.1 218702520 7151861 4452203..4452361 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4452361 7151861 ECIAI39_4275 Escherichia coli IAI39 hypothetical protein YP_002410149.1 4452203 D 585057 CDS YP_002410150.1 218702521 7150337 4452494..4452583 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; toxic peptide TisB 4452583 7150337 ECIAI39_4276 Escherichia coli IAI39 toxic peptide TisB YP_002410150.1 4452494 D 585057 CDS YP_002410151.1 218702522 7150338 4452863..4454047 1 NC_011750.1 multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 4454047 emrD 7150338 emrD Escherichia coli IAI39 multidrug resistance protein D YP_002410151.1 4452863 D 585057 CDS YP_002410152.1 218702523 7151216 complement(4454055..4454552) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4454552 yidF 7151216 yidF Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002410152.1 4454055 R 585057 CDS YP_002410153.1 218702524 7154184 complement(4454549..4454911) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4454911 yidG 7154184 yidG Escherichia coli IAI39 hypothetical protein YP_002410153.1 4454549 R 585057 CDS YP_002410154.1 218702525 7154185 complement(4454901..4455248) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4455248 yidH 7154185 yidH Escherichia coli IAI39 hypothetical protein YP_002410154.1 4454901 R 585057 CDS YP_002410155.1 218702526 7154186 complement(4455308..4456801) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sulfatase/phosphatase 4456801 yidJ 7154186 yidJ Escherichia coli IAI39 putative sulfatase/phosphatase YP_002410155.1 4455308 R 585057 CDS YP_002410156.1 218702527 7154187 complement(4456798..4458513) 1 NC_011750.1 uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function; putative symporter YidK 4458513 yidK 7154187 yidK Escherichia coli IAI39 putative symporter YidK YP_002410156.1 4456798 R 585057 CDS YP_002410157.1 218702528 7154188 4458650..4459573 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4459573 yidL 7154188 yidL Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002410157.1 4458650 D 585057 CDS YP_002410158.1 218702529 7154189 complement(4459570..4460892) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; 6-phospho-glucosidase 4460892 7154189 ECIAI39_4284 Escherichia coli IAI39 6-phospho-glucosidase YP_002410158.1 4459570 R 585057 CDS YP_002410159.1 218702530 7150339 complement(4460892..4462769) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative PTS system alpha-glucoside-specific EIICB component 4462769 7150339 ECIAI39_4285 Escherichia coli IAI39 putative PTS system alpha-glucoside-specific EIICB component YP_002410159.1 4460892 R 585057 CDS YP_002410160.1 218702531 7150340 4462804..4463520 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4463520 yidP 7150340 yidP Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002410160.1 4462804 D 585057 CDS YP_002410161.1 218702532 7154190 complement(4463517..4465178) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1356969; Product type pt : putative transporter; hypothetical protein 4465178 yidE 7154190 yidE Escherichia coli IAI39 hypothetical protein YP_002410161.1 4463517 R 585057 CDS YP_002410162.1 218702533 7154183 complement(4465374..4465802) 1 NC_011750.1 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB 4465802 ibpB 7154183 ibpB Escherichia coli IAI39 heat shock chaperone IbpB YP_002410162.1 4465374 R 585057 CDS YP_002410163.1 218702534 7151745 complement(4465914..4466327) 1 NC_011750.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA 4466327 ibpA 7151745 ibpA Escherichia coli IAI39 heat shock protein IbpA YP_002410163.1 4465914 R 585057 CDS YP_002410164.1 218702535 7151744 4466633..4466965 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4466965 yidQ 7151744 yidQ Escherichia coli IAI39 hypothetical protein YP_002410164.1 4466633 D 585057 CDS YP_002410165.1 218702536 7154191 complement(4466967..4468181) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4468181 yidR 7154191 yidR Escherichia coli IAI39 hypothetical protein YP_002410165.1 4466967 R 585057 CDS YP_002410166.1 218702537 7154192 4468282..4469346 1 NC_011750.1 FAD/NAD(P)-binding domain; putative oxidoreductase 4469346 cbrA 7154192 cbrA Escherichia coli IAI39 putative oxidoreductase YP_002410166.1 4468282 D 585057 CDS YP_002410167.1 218702538 7150907 complement(4469343..4470635) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type t : transporter; D-galactonate transporter 4470635 dgoT 7150907 dgoT Escherichia coli IAI39 D-galactonate transporter YP_002410167.1 4469343 R 585057 CDS YP_002410168.1 218702539 7151130 complement(4470755..4471903) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type e : enzyme; galactonate dehydratase 4471903 dgoD 7151130 dgoD Escherichia coli IAI39 galactonate dehydratase YP_002410168.1 4470755 R 585057 CDS YP_002410169.1 218702540 7151127 complement(4471900..4472517) 1 NC_011750.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase 4472517 dgoA 7151127 dgoA Escherichia coli IAI39 2-dehydro-3-deoxy-6-phosphogalactonate aldolase YP_002410169.1 4471900 R 585057 CDS YP_002410170.1 218702541 7151126 complement(4472501..4473379) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type e : enzyme; 2-oxo-3-deoxygalactonate kinase 4473379 dgoK 7151126 dgoK Escherichia coli IAI39 2-oxo-3-deoxygalactonate kinase YP_002410170.1 4472501 R 585057 CDS YP_002410171.1 218702542 7151128 complement(4473376..4474065) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 79020349; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4474065 dgoR 7151128 dgoR Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002410171.1 4473376 R 585057 CDS YP_002410172.1 218702543 7151129 4474226..4474999 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 4474999 yidX 7151129 yidX Escherichia coli IAI39 hypothetical protein YP_002410172.1 4474226 D 585057 CDS YP_002410173.1 218702544 7154193 complement(4475043..4475855) 1 NC_011750.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase 4475855 yidA 7154193 yidA Escherichia coli IAI39 sugar phosphatase YP_002410173.1 4475043 R 585057 CDS YP_002410174.1 218702545 7154179 complement(4475970..4476368) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4476368 yidB 7154179 yidB Escherichia coli IAI39 hypothetical protein YP_002410174.1 4475970 R 585057 CDS YP_002410175.1 218702546 7154180 complement(4476539..4477261) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 4477261 7154180 ECIAI39_4301 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002410175.1 4476539 R 585057 CDS YP_002410176.1 218702547 7150341 complement(4477366..4477896) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 4477896 7150341 ECIAI39_4302 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002410176.1 4477366 R 585057 CDS YP_002410177.1 218702548 7150342 complement(4478043..4480457) 1 NC_011750.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 4480457 gyrB 7150342 gyrB Escherichia coli IAI39 DNA gyrase subunit B YP_002410177.1 4478043 R 585057 CDS YP_002410178.1 218702549 7151606 complement(4480486..4481559) 1 NC_011750.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 4481559 recF 7151606 recF Escherichia coli IAI39 recombination protein F YP_002410178.1 4480486 R 585057 CDS YP_002410179.1 218702550 7152591 complement(4481559..4482659) 1 NC_011750.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 4482659 dnaN 7152591 dnaN Escherichia coli IAI39 DNA polymerase III subunit beta YP_002410179.1 4481559 R 585057 CDS YP_002410180.1 218702551 7151160 complement(4482664..4484067) 1 NC_011750.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 4484067 dnaA 7151160 dnaA Escherichia coli IAI39 chromosomal replication initiation protein YP_002410180.1 4482664 R 585057 CDS YP_002410181.1 218702552 7151153 4484674..4484814 1 NC_011750.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 4484814 rpmH 7151153 rpmH Escherichia coli IAI39 50S ribosomal protein L34 YP_002410181.1 4484674 D 585057 CDS YP_002410182.1 218702553 7152701 4484831..4485190 1 NC_011750.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 4485190 rnpA 7152701 rnpA Escherichia coli IAI39 ribonuclease P YP_002410182.1 4484831 D 585057 CDS YP_002410183.1 218702554 7152661 4485154..4485411 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4485411 yidD 7152661 yidD Escherichia coli IAI39 hypothetical protein YP_002410183.1 4485154 D 585057 CDS YP_002410184.1 218702555 7154182 4485414..4487060 1 NC_011750.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; putative inner membrane protein translocase component YidC 4487060 yidC 7154182 yidC Escherichia coli IAI39 putative inner membrane protein translocase component YidC YP_002410184.1 4485414 D 585057 CDS YP_002410185.1 218702556 7154181 4487166..4488530 1 NC_011750.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 4488530 trmE 7154181 trmE Escherichia coli IAI39 tRNA modification GTPase TrmE YP_002410185.1 4487166 D 585057 CDS YP_002410186.1 218702557 7153028 4488772..4488846 1 NC_011750.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; tryptophanase leader peptide 4488846 tnaC 7153028 tnaC Escherichia coli IAI39 tryptophanase leader peptide YP_002410186.1 4488772 D 585057 CDS YP_002410187.1 218702558 7152995 4489066..4490481 1 NC_011750.1 tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 4490481 tnaA 7152995 tnaA Escherichia coli IAI39 tryptophanase YP_002410187.1 4489066 D 585057 CDS YP_002410188.1 218702559 7152993 4490573..4491820 1 NC_011750.1 tryptophan transporter of low affinity; tryptophan permease TnaB 4491820 tnaB 7152993 tnaB Escherichia coli IAI39 tryptophan permease TnaB YP_002410188.1 4490573 D 585057 CDS YP_002410189.1 218702560 7152994 4491953..4493128 1 NC_011750.1 Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 4493128 mdtL 7152994 mdtL Escherichia coli IAI39 multidrug efflux system protein MdtL YP_002410189.1 4491953 D 585057 CDS YP_002410190.1 218702561 7152039 4493103..4494062 1 NC_011750.1 Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ 4494062 yidZ 7152039 yidZ Escherichia coli IAI39 DNA-binding transcriptional regulator YidZ YP_002410190.1 4493103 D 585057 CDS YP_002410191.1 218702562 7154194 4494207..4494968 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphopantetheinyl transferase 4494968 yieE 7154194 yieE Escherichia coli IAI39 putative phosphopantetheinyl transferase YP_002410191.1 4494207 D 585057 CDS YP_002410192.1 218702563 7154195 4494990..4495556 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14766567; Product type e : enzyme; chromate reductase, Class I, flavoprotein 4495556 yieF 7154195 yieF Escherichia coli IAI39 chromate reductase, Class I, flavoprotein YP_002410192.1 4494990 D 585057 CDS YP_002410193.1 218702564 7154196 complement(4495610..4496947) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4496947 yieG 7154196 yieG Escherichia coli IAI39 hypothetical protein YP_002410193.1 4495610 R 585057 CDS YP_002410194.1 218702565 7154197 4497114..4497779 1 NC_011750.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 4497779 yieH 7154197 yieH Escherichia coli IAI39 6-phosphogluconate phosphatase YP_002410194.1 4497114 D 585057 CDS YP_002410195.1 218702566 7154198 complement(4497916..4500342) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4500342 7154198 ECIAI39_4320 Escherichia coli IAI39 hypothetical protein YP_002410195.1 4497916 R 585057 CDS YP_002410196.1 218702567 7150343 4500625..4501812 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4501812 7150343 ECIAI39_4321 Escherichia coli IAI39 hypothetical protein YP_002410196.1 4500625 D 585057 CDS YP_002410197.1 218702568 7150344 4501988..4502137 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4502137 7150344 ECIAI39_4322 Escherichia coli IAI39 hypothetical protein YP_002410197.1 4501988 D 585057 CDS YP_002410198.1 218702569 7150345 complement(4502282..4504792) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4504792 7150345 ECIAI39_4323 Escherichia coli IAI39 hypothetical protein YP_002410198.1 4502282 R 585057 CDS YP_002410199.1 218702570 7150346 complement(4505198..4505923) 1 NC_011750.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU 4505923 phoU 7150346 phoU Escherichia coli IAI39 transcriptional regulator PhoU YP_002410199.1 4505198 R 585057 CDS YP_002410200.1 218702571 7152416 complement(4505938..4506711) 1 NC_011750.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 4506711 pstB 7152416 pstB Escherichia coli IAI39 phosphate transporter ATP-binding protein YP_002410200.1 4505938 R 585057 CDS YP_002410201.1 218702572 7152510 complement(4506802..4507692) 1 NC_011750.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PtsA 4507692 pstA 7152510 pstA Escherichia coli IAI39 phosphate transporter permease subunit PtsA YP_002410201.1 4506802 R 585057 CDS YP_002410202.1 218702573 7152509 complement(4507692..4508651) 1 NC_011750.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PstC 4508651 pstC 7152509 pstC Escherichia coli IAI39 phosphate transporter permease subunit PstC YP_002410202.1 4507692 R 585057 CDS YP_002410203.1 218702574 7152511 complement(4508738..4509778) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90133909, 2215649, 6321434, 6365894, 9228942, 9298646, 9671506; Product type t : transporter; phosphate ABC transporter periplasmic substrate-binding protein PstS 4509778 pstS 7152511 pstS Escherichia coli IAI39 phosphate ABC transporter periplasmic substrate-binding protein PstS YP_002410203.1 4508738 R 585057 CDS YP_002410204.1 218702575 7152512 complement(4510026..4511096) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12438351, 7721701, 16128397; Product type ps : putative structure; putative fimbrial protein LpfD; putative adhesin 4511096 lpfD 7152512 lpfD Escherichia coli IAI39 putative fimbrial protein LpfD; putative adhesin YP_002410204.1 4510026 R 585057 CDS YP_002410205.1 218702576 7151960 complement(4511107..4513629) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7721701, 16128397; Product type pt : putative transporter; putative fimbrial usher 4513629 lpfC 7151960 lpfC Escherichia coli IAI39 putative fimbrial usher YP_002410205.1 4511107 R 585057 CDS YP_002410206.1 218702577 7151959 complement(4513654..4514385) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16128397, 12438351; Product type pc : putative carrier; putative fimbrial chaperone protein 4514385 lfpB 7151959 lfpB Escherichia coli IAI39 putative fimbrial chaperone protein YP_002410206.1 4513654 R 585057 CDS YP_002410207.1 218702578 7151932 complement(4514433..4515005) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16125910, 12438351; Product type ps : putative structure; putative major fimbrial subunit 4515005 lpfA 7151932 lpfA Escherichia coli IAI39 putative major fimbrial subunit YP_002410207.1 4514433 R 585057 CDS YP_002410208.1 218702579 7151958 complement(4515313..4517142) 1 NC_011750.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 4517142 glmS 7151958 glmS Escherichia coli IAI39 glucosamine--fructose-6-phosphate aminotransferase YP_002410208.1 4515313 R 585057 CDS YP_002410209.1 218702580 7151521 complement(4517304..4518674) 1 NC_011750.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 4518674 glmU 7151521 glmU Escherichia coli IAI39 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_002410209.1 4517304 R 585057 CDS YP_002410210.1 218702581 7151522 complement(4519023..4519442) 1 NC_011750.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 4519442 atpC 7151522 atpC Escherichia coli IAI39 F0F1 ATP synthase subunit epsilon YP_002410210.1 4519023 R 585057 CDS YP_002410211.1 218702582 7150823 complement(4519463..4520845) 1 NC_011750.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 4520845 atpD 7150823 atpD Escherichia coli IAI39 F0F1 ATP synthase subunit beta YP_002410211.1 4519463 R 585057 CDS YP_002410212.1 218702583 7150824 complement(4520872..4521735) 1 NC_011750.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 4521735 atpG 7150824 atpG Escherichia coli IAI39 F0F1 ATP synthase subunit gamma YP_002410212.1 4520872 R 585057 CDS YP_002410213.1 218702584 7150827 complement(4521786..4523327) 1 NC_011750.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 4523327 atpA 7150827 atpA Escherichia coli IAI39 F0F1 ATP synthase subunit alpha YP_002410213.1 4521786 R 585057 CDS YP_002410214.1 218702585 7150821 complement(4523340..4523873) 1 NC_011750.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 4523873 atpH 7150821 atpH Escherichia coli IAI39 F0F1 ATP synthase subunit delta YP_002410214.1 4523340 R 585057 CDS YP_002410215.1 218702586 7150828 complement(4523888..4524358) 1 NC_011750.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 4524358 atpF 7150828 atpF Escherichia coli IAI39 F0F1 ATP synthase subunit B YP_002410215.1 4523888 R 585057 CDS YP_002410216.1 218702587 7150826 complement(4524420..4524659) 1 NC_011750.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 4524659 atpE 7150826 atpE Escherichia coli IAI39 F0F1 ATP synthase subunit C YP_002410216.1 4524420 R 585057 CDS YP_002410217.1 218702588 7150825 complement(4524706..4525521) 1 NC_011750.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 4525521 atpB 7150825 atpB Escherichia coli IAI39 F0F1 ATP synthase subunit A YP_002410217.1 4524706 R 585057 CDS YP_002410218.1 218702589 7150822 complement(4525530..4525910) 1 NC_011750.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I 4525910 atpI 7150822 atpI Escherichia coli IAI39 F0F1 ATP synthase subunit I YP_002410218.1 4525530 R 585057 CDS YP_002410219.1 218702590 7150829 complement(4526527..4527150) 1 NC_011750.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 4527150 gidB 7150829 gidB Escherichia coli IAI39 16S rRNA methyltransferase GidB YP_002410219.1 4526527 R 585057 CDS YP_002410220.1 218702591 7151504 complement(4527214..4529103) 1 NC_011750.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 4529103 gidA 7151504 gidA Escherichia coli IAI39 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA YP_002410220.1 4527214 R 585057 CDS YP_002410221.1 218702592 7151503 complement(4529482..4529925) 1 NC_011750.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 4529925 mioC 7151503 mioC Escherichia coli IAI39 flavodoxin YP_002410221.1 4529482 R 585057 CDS YP_002410222.1 218702593 7152086 complement(4530015..4530473) 1 NC_011750.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 4530473 asnC 7152086 asnC Escherichia coli IAI39 DNA-binding transcriptional regulator AsnC YP_002410222.1 4530015 R 585057 CDS YP_002410223.1 218702594 7150804 4530625..4531617 1 NC_011750.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 4531617 asnA 7150804 asnA Escherichia coli IAI39 asparagine synthetase AsnA YP_002410223.1 4530625 D 585057 CDS YP_002410224.1 218702595 7150802 complement(4531622..4533073) 1 NC_011750.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein 4533073 yieM 7150802 yieM Escherichia coli IAI39 hypothetical protein YP_002410224.1 4531622 R 585057 CDS YP_002410225.1 218702596 7154199 complement(4533067..4534563) 1 NC_011750.1 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA 4534563 ravA 7154199 ravA Escherichia coli IAI39 regulatory ATPase RavA YP_002410225.1 4533067 R 585057 CDS YP_002410226.1 218702597 7152567 4534719..4536065 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase, IS4 4536065 insG 7152567 insG Escherichia coli IAI39 transposase, IS4 YP_002410226.1 4534719 D 585057 CDS YP_002410227.1 218702598 7151819 4536224..4538092 1 NC_011750.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 4538092 trkD 7151819 trkD Escherichia coli IAI39 potassium transport protein Kup YP_002410227.1 4536224 D 585057 CDS YP_002410228.1 218702599 7153023 4538259..4538678 1 NC_011750.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 4538678 rbsD 7153023 rbsD Escherichia coli IAI39 D-ribose pyranase YP_002410228.1 4538259 D 585057 CDS YP_002410229.1 218702600 7152574 4538686..4540191 1 NC_011750.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP binding protein 4540191 rbsA 7152574 rbsA Escherichia coli IAI39 D-ribose transporter ATP binding protein YP_002410229.1 4538686 D 585057 CDS YP_002410230.1 218702601 7152571 4540196..4541161 1 NC_011750.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 4541161 rbsC 7152571 rbsC Escherichia coli IAI39 ribose ABC transporter permease YP_002410230.1 4540196 D 585057 CDS YP_002410231.1 218702602 7152573 4541186..4542076 1 NC_011750.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 4542076 rbsB 7152573 rbsB Escherichia coli IAI39 D-ribose transporter subunit RbsB YP_002410231.1 4541186 D 585057 CDS YP_002410232.1 218702603 7152572 4542202..4543131 1 NC_011750.1 catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 4543131 rbsK 7152572 rbsK Escherichia coli IAI39 ribokinase YP_002410232.1 4542202 D 585057 CDS YP_002410233.1 218702604 7152575 4543135..4544127 1 NC_011750.1 DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 4544127 rbsR 7152575 rbsR Escherichia coli IAI39 transcriptional repressor RbsR YP_002410233.1 4543135 D 585057 CDS YP_002410234.1 218702605 7152576 complement(4544093..4545520) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 20218988, 12107133; Product type t : transporter; multidrug or homocysteine efflux system 4545520 hsrA 7152576 hsrA Escherichia coli IAI39 multidrug or homocysteine efflux system YP_002410234.1 4544093 R 585057 CDS YP_002410235.1 218702606 7151685 complement(4545543..4546235) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4546235 yieP 7151685 yieP Escherichia coli IAI39 putative transcriptional regulator YP_002410235.1 4545543 R 585057 CDS YP_002410236.1 218702607 7150516 4551902..4552930 1 NC_011750.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 4552930 murB 7150516 murB Escherichia coli IAI39 UDP-N-acetylenolpyruvoylglucosamine reductase YP_002410236.1 4551902 D 585057 CDS YP_002410237.1 218702608 7152146 4552927..4553892 1 NC_011750.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 4553892 birA 7152146 birA Escherichia coli IAI39 biotin--protein ligase YP_002410237.1 4552927 D 585057 CDS YP_002410238.1 218702609 7150869 complement(4553921..4554871) 1 NC_011750.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 4554871 coaA 7150869 coaA Escherichia coli IAI39 pantothenate kinase YP_002410238.1 4553921 R 585057 CDS YP_002410239.1 218702610 7150578 4555789..4556973 1 NC_011750.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4556973 tufB 7150578 tufB Escherichia coli IAI39 elongation factor Tu YP_002410239.1 4555789 D 585057 CDS YP_002410240.1 218702611 7153055 4557203..4557586 1 NC_011750.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 4557586 secE 7153055 secE Escherichia coli IAI39 preprotein translocase subunit SecE YP_002410240.1 4557203 D 585057 CDS YP_002410241.1 218702612 7152821 4557588..4558133 1 NC_011750.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 4558133 nusG 7152821 nusG Escherichia coli IAI39 transcription antitermination protein NusG YP_002410241.1 4557588 D 585057 CDS YP_002410242.1 218702613 7152286 4558292..4558720 1 NC_011750.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 4558720 rplK 7152286 rplK Escherichia coli IAI39 50S ribosomal protein L11 YP_002410242.1 4558292 D 585057 CDS YP_002410243.1 218702614 7152679 4558724..4559428 1 NC_011750.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 4559428 rplA 7152679 rplA Escherichia coli IAI39 50S ribosomal protein L1 YP_002410243.1 4558724 D 585057 CDS YP_002410244.1 218702615 7152671 4559720..4560217 1 NC_011750.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 4560217 rplJ 7152671 rplJ Escherichia coli IAI39 50S ribosomal protein L10 YP_002410244.1 4559720 D 585057 CDS YP_002410245.1 218702616 7152678 4560284..4560649 1 NC_011750.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 4560649 rplL 7152678 rplL Escherichia coli IAI39 50S ribosomal protein L7/L12 YP_002410245.1 4560284 D 585057 CDS YP_002410246.1 218702617 7152680 4560969..4564997 1 NC_011750.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 4564997 rpoB 7152680 rpoB Escherichia coli IAI39 DNA-directed RNA polymerase subunit beta YP_002410246.1 4560969 D 585057 CDS YP_002410247.1 218702618 7152704 4565074..4569297 1 NC_011750.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 4569297 rpoC 7152704 rpoC Escherichia coli IAI39 DNA-directed RNA polymerase subunit beta' YP_002410247.1 4565074 D 585057 CDS YP_002410248.1 218702619 7152705 4569554..4570771 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative carbohydrate kinase 4570771 7152705 ECIAI39_4374 Escherichia coli IAI39 putative carbohydrate kinase YP_002410248.1 4569554 D 585057 CDS YP_002410249.1 218702620 7150347 4570773..4571399 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease of transport system 4571399 7150347 ECIAI39_4375 Escherichia coli IAI39 putative permease of transport system YP_002410249.1 4570773 D 585057 CDS YP_002410250.1 218702621 7150348 4571451..4572272 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease of a carbohydrate transport system 4572272 7150348 ECIAI39_4376 Escherichia coli IAI39 putative permease of a carbohydrate transport system YP_002410250.1 4571451 D 585057 CDS YP_002410251.1 218702622 7150349 4572232..4574919 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4574919 7150349 ECIAI39_4377 Escherichia coli IAI39 hypothetical protein YP_002410251.1 4572232 D 585057 CDS YP_002410252.1 218702623 7150350 complement(4574950..4575600) 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4575600 7150350 ECIAI39_4378 Escherichia coli IAI39 hypothetical protein YP_002410252.1 4574950 R 585057 CDS YP_002410253.1 218702624 7150351 complement(4575918..4577051) 1 NC_011750.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH 4577051 thiH 7150351 thiH Escherichia coli IAI39 thiamine biosynthesis protein ThiH YP_002410253.1 4575918 R 585057 CDS YP_002410254.1 218702625 7152970 complement(4577048..4577818) 1 NC_011750.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 4577818 thiG 7152970 thiG Escherichia coli IAI39 thiazole synthase YP_002410254.1 4577048 R 585057 CDS YP_002410255.1 218702626 7152969 complement(4577820..4578020) 1 NC_011750.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS 4578020 thiS 7152969 thiS Escherichia coli IAI39 sulfur carrier protein ThiS YP_002410255.1 4577820 R 585057 CDS YP_002410256.1 218702627 7152976 complement(4578004..4578759) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8432721, 94089392, 98298179, 10082377, 9632726; Product type e : enzyme; thiamin (thiazole moiety) biosynthesis protein 4578759 thiF 7152976 thiF Escherichia coli IAI39 thiamin (thiazole moiety) biosynthesis protein YP_002410256.1 4578004 R 585057 CDS YP_002410257.1 218702628 7152968 complement(4578752..4579387) 1 NC_011750.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase 4579387 thiE 7152968 thiE Escherichia coli IAI39 thiamine-phosphate pyrophosphorylase YP_002410257.1 4578752 R 585057 CDS YP_002410258.1 218702629 7152967 complement(4579387..4581282) 1 NC_011750.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 4581282 thiC 7152967 thiC Escherichia coli IAI39 thiamine biosynthesis protein ThiC YP_002410258.1 4579387 R 585057 CDS YP_002410259.1 218702630 7150549 complement(4581515..4581991) 1 NC_011750.1 binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor 4581991 rsd 7150549 rsd Escherichia coli IAI39 anti-RNA polymerase sigma 70 factor YP_002410259.1 4581515 R 585057 CDS YP_002410260.1 218702631 7152737 4582086..4582859 1 NC_011750.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 4582859 nudC 7152737 nudC Escherichia coli IAI39 NADH pyrophosphatase YP_002410260.1 4582086 D 585057 CDS YP_002410261.1 218702632 7152263 4582899..4583963 1 NC_011750.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 4583963 hemE 7152263 hemE Escherichia coli IAI39 uroporphyrinogen decarboxylase YP_002410261.1 4582899 D 585057 CDS YP_002410262.1 218702633 7151628 4583973..4584644 1 NC_011750.1 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 4584644 nfi 7151628 nfi Escherichia coli IAI39 endonuclease V YP_002410262.1 4583973 D 585057 CDS YP_002410263.1 218702634 7152213 4584687..4585277 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4585277 yjaG 7152213 yjaG Escherichia coli IAI39 hypothetical protein YP_002410263.1 4584687 D 585057 CDS YP_002410264.1 218702635 7154252 4585464..4585736 1 NC_011750.1 histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 4585736 hupA 7154252 hupA Escherichia coli IAI39 transcriptional regulator HU subunit alpha YP_002410264.1 4585464 D 585057 CDS YP_002410265.1 218702636 7151691 4585749..4586444 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4586444 yjaH 7151691 yjaH Escherichia coli IAI39 hypothetical protein YP_002410265.1 4585749 D 585057 CDS YP_002410266.1 218702637 7154253 complement(4586446..4587006) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98362023, 9694902; Product type pf : putative factor; zinc resistance protein 4587006 zraP 7154253 zraP Escherichia coli IAI39 zinc resistance protein YP_002410266.1 4586446 R 585057 CDS YP_002410267.1 218702638 7154595 4587103..4588479 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21140164, 89327164, 92255260, 11243806, 2666400; Product type r : regulator; sensor protein ZraS 4588479 zraS 7154595 zraS Escherichia coli IAI39 sensor protein ZraS YP_002410267.1 4587103 D 585057 CDS YP_002410268.1 218702639 7154597 4588476..4589801 1 NC_011750.1 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 4589801 zraR 7154597 zraR Escherichia coli IAI39 transcriptional regulatory protein ZraR YP_002410268.1 4588476 D 585057 CDS YP_002410269.1 218702640 7154596 complement(4589798..4591087) 1 NC_011750.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 4591087 purD 7154596 purD Escherichia coli IAI39 phosphoribosylamine--glycine ligase YP_002410269.1 4589798 R 585057 CDS YP_002410270.1 218702641 7152526 complement(4591099..4592688) 1 NC_011750.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 4592688 purH 7152526 purH Escherichia coli IAI39 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_002410270.1 4591099 R 585057 CDS YP_002410271.1 218702642 7152529 complement(4592642..4592791) 1 NC_011750.1 hypothetical protein 4592791 7152529 ECIAI39_4397 Escherichia coli IAI39 hypothetical protein YP_002410271.1 4592642 R 585057 CDS YP_002410272.1 218702643 7150517 complement(4598433..4598876) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; hypothetical protein 4598876 yjaB 7150517 yjaB Escherichia coli IAI39 hypothetical protein YP_002410272.1 4598433 R 585057 CDS YP_002410273.1 218702644 7154251 4599033..4599962 1 NC_011750.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 4599962 metA 7154251 metA Escherichia coli IAI39 homoserine O-succinyltransferase YP_002410273.1 4599033 D 585057 CDS YP_002410274.1 218702645 7152050 4600231..4601832 1 NC_011750.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 4601832 aceB 7152050 aceB Escherichia coli IAI39 malate synthase YP_002410274.1 4600231 D 585057 CDS YP_002410275.1 218702646 7150661 4601862..4603166 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91295197, 92112731, 92353108, 2836370, 3049537, 3060852, 3276689, 3290857, 3291954, 7826335; Product type e : enzyme; isocitrate lyase 4603166 aceA 7150661 aceA Escherichia coli IAI39 isocitrate lyase YP_002410275.1 4601862 D 585057 CDS YP_002410276.1 218702647 7150660 4603252..4603782 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 4603782 7150660 ECIAI39_4402 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002410276.1 4603252 D 585057 CDS YP_002410277.1 218702648 7150353 4603887..4604609 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 4604609 7150353 ECIAI39_4403 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002410277.1 4603887 D 585057 CDS YP_002410278.1 218702649 7150354 4604786..4606510 1 NC_011750.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol; bifunctional isocitrate dehydrogenase kinase/phosphatase protein 4606510 aceK 7150354 aceK Escherichia coli IAI39 bifunctional isocitrate dehydrogenase kinase/phosphatase protein YP_002410278.1 4604786 D 585057 CDS YP_002410279.1 218702650 7150664 complement(4606527..4607351) 1 NC_011750.1 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; transcriptional repressor IclR 4607351 iclR 7150664 iclR Escherichia coli IAI39 transcriptional repressor IclR YP_002410279.1 4606527 R 585057 CDS YP_002410280.1 218702651 7151752 4607551..4611234 1 NC_011750.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 4611234 metH 7151752 metH Escherichia coli IAI39 B12-dependent methionine synthase YP_002410280.1 4607551 D 585057 CDS YP_002410281.1 218702652 7152056 4611288..4611614 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4611614 7152056 ECIAI39_4407 Escherichia coli IAI39 hypothetical protein YP_002410281.1 4611288 D 585057 CDS YP_002410282.1 218702653 7150355 4611657..4612106 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4612106 7150355 ECIAI39_4408 Escherichia coli IAI39 hypothetical protein YP_002410282.1 4611657 D 585057 CDS YP_002410283.1 218702654 7150356 4612277..4613908 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4613908 yjbB 7150356 yjbB Escherichia coli IAI39 putative transporter YP_002410283.1 4612277 D 585057 CDS YP_002410284.1 218702655 7154255 complement(4613998..4614687) 1 NC_011750.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E 4614687 pepE 7154255 pepE Escherichia coli IAI39 peptidase E YP_002410284.1 4613998 R 585057 CDS YP_002410285.1 218702656 7152364 complement(4614810..4615622) 1 NC_011750.1 catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 4615622 7152364 ECIAI39_4411 Escherichia coli IAI39 shikimate 5-dehydrogenase YP_002410285.1 4614810 R 585057 CDS YP_002410286.1 218702657 7150357 complement(4615615..4616856) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968, 7652212; Product type e : enzyme; L-sorbose 1-phosphate reductase 4616856 7150357 ECIAI39_4412 Escherichia coli IAI39 L-sorbose 1-phosphate reductase YP_002410286.1 4615615 R 585057 CDS YP_002410287.1 218702658 7150358 complement(4616896..4617750) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968, 7700234; Product type t : transporter; sorbose permease IID component 4617750 7150358 ECIAI39_4413 Escherichia coli IAI39 sorbose permease IID component YP_002410287.1 4616896 R 585057 CDS YP_002410288.1 218702659 7150359 complement(4617731..4618528) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968, 7700234; Product type t : transporter; sorbose permease IIC component (PTS system) 4618528 7150359 ECIAI39_4414 Escherichia coli IAI39 sorbose permease IIC component (PTS system) YP_002410288.1 4617731 R 585057 CDS YP_002410289.1 218702660 7150360 complement(4618594..4619088) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968, 7700234, 12662934; Product type t : transporter; sorbose-specific phosphotransferase enzyme IIB component (PTS system) 4619088 7150360 ECIAI39_4415 Escherichia coli IAI39 sorbose-specific phosphotransferase enzyme IIB component (PTS system) YP_002410289.1 4618594 R 585057 CDS YP_002410290.1 218702661 7150361 complement(4619088..4619495) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968; Product type t : transporter; sorbose-specific phosphotransferase enzyme IIA component (PTS system) 4619495 7150361 ECIAI39_4416 Escherichia coli IAI39 sorbose-specific phosphotransferase enzyme IIA component (PTS system) YP_002410290.1 4619088 R 585057 CDS YP_002410291.1 218702662 7150362 complement(4619505..4620311) 1 NC_011750.1 Converts D-sorbitol-dphosphate to D-fructose-6-phosphate; sorbitol-6-phosphate 2-dehydrogenase 4620311 7150362 ECIAI39_4417 Escherichia coli IAI39 sorbitol-6-phosphate 2-dehydrogenase YP_002410291.1 4619505 R 585057 CDS YP_002410292.1 218702663 7150363 complement(4620381..4621379) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968; Product type r : regulator; sorbitol/sorbose operon activator 4621379 7150363 ECIAI39_4418 Escherichia coli IAI39 sorbitol/sorbose operon activator YP_002410292.1 4620381 R 585057 CDS YP_002410293.1 218702664 7150364 4621592..4622464 1 NC_011750.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 4622464 yjbC 7150364 yjbC Escherichia coli IAI39 23S rRNA pseudouridine synthase F YP_002410293.1 4621592 D 585057 CDS YP_002410294.1 218702665 7154256 complement(4622465..4622737) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4622737 yjbD 7154256 yjbD Escherichia coli IAI39 hypothetical protein YP_002410294.1 4622465 R 585057 CDS YP_002410295.1 218702666 7150365 4623266..4624393 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4624393 7150365 ECIAI39_4422 Escherichia coli IAI39 hypothetical protein YP_002410295.1 4623266 D 585057 CDS YP_002410296.1 218702667 7150366 4624390..4625190 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4625190 7150366 ECIAI39_4423 Escherichia coli IAI39 hypothetical protein YP_002410296.1 4624390 D 585057 CDS YP_002410297.1 218702668 7150367 complement(4625205..4625660) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4625660 7150367 ECIAI39_4424 Escherichia coli IAI39 hypothetical protein YP_002410297.1 4625205 R 585057 CDS YP_002410298.1 218702669 7150368 complement(4625657..4626364) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative phage tail fiber assembly protein 4626364 7150368 ECIAI39_4425 Escherichia coli IAI39 putative phage tail fiber assembly protein YP_002410298.1 4625657 R 585057 CDS YP_002410299.1 218702670 7150369 complement(4626361..4627941) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative side tail phage protein 4627941 7150369 ECIAI39_4426 Escherichia coli IAI39 putative side tail phage protein YP_002410299.1 4626361 R 585057 CDS YP_002410300.1 218702671 7150370 complement(4627944..4628675) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative phage tail protein 4628675 7150370 ECIAI39_4427 Escherichia coli IAI39 putative phage tail protein YP_002410300.1 4627944 R 585057 CDS YP_002410301.1 218702672 7150371 complement(4628653..4629768) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative phage baseplate protein 4629768 7150371 ECIAI39_4428 Escherichia coli IAI39 putative phage baseplate protein YP_002410301.1 4628653 R 585057 CDS YP_002410302.1 218702673 7150372 complement(4629759..4630118) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative phage baseplate protein 4630118 7150372 ECIAI39_4429 Escherichia coli IAI39 putative phage baseplate protein YP_002410302.1 4629759 R 585057 CDS YP_002410303.1 218702674 7150373 complement(4630217..4630918) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7483254; Product type ps : putative structure; putative phage baseplate component 4630918 7150373 ECIAI39_4430 Escherichia coli IAI39 putative phage baseplate component YP_002410303.1 4630217 R 585057 CDS YP_002410304.1 218702675 7150374 complement(4630928..4631968) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative control protein for phage late genes expression 4631968 7150374 ECIAI39_4431 Escherichia coli IAI39 putative control protein for phage late genes expression YP_002410304.1 4630928 R 585057 CDS YP_002410305.1 218702676 7150375 complement(4631956..4632168) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative phage tail protein 4632168 7150375 ECIAI39_4432 Escherichia coli IAI39 putative phage tail protein YP_002410305.1 4631956 R 585057 CDS YP_002410306.1 218702677 7150376 complement(4632165..4633118) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; hypothetical protein 4633118 7150376 ECIAI39_4433 Escherichia coli IAI39 hypothetical protein YP_002410306.1 4632165 R 585057 CDS YP_002410307.1 218702678 7150377 complement(4633118..4635493) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative phage tail protein 4635493 7150377 ECIAI39_4434 Escherichia coli IAI39 putative phage tail protein YP_002410307.1 4633118 R 585057 CDS YP_002410308.1 218702679 7150378 complement(4635683..4636000) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4636000 7150378 ECIAI39_4435 Escherichia coli IAI39 hypothetical protein YP_002410308.1 4635683 R 585057 CDS YP_002410309.1 218702680 7150379 complement(4636051..4636575) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage tail core protein 4636575 7150379 ECIAI39_4436 Escherichia coli IAI39 phage tail core protein YP_002410309.1 4636051 R 585057 CDS YP_002410310.1 218702681 7150380 complement(4636575..4638005) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1825255; Product type ps : putative structure; putative phage tail sheath protein 4638005 7150380 ECIAI39_4437 Escherichia coli IAI39 putative phage tail sheath protein YP_002410310.1 4636575 R 585057 CDS YP_002410311.1 218702682 7150381 complement(4637989..4638186) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4638186 7150381 ECIAI39_4438 Escherichia coli IAI39 hypothetical protein YP_002410311.1 4637989 R 585057 CDS YP_002410312.1 218702683 7150382 complement(4638183..4638638) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4638638 7150382 ECIAI39_4439 Escherichia coli IAI39 hypothetical protein YP_002410312.1 4638183 R 585057 CDS YP_002410313.1 218702684 7150383 complement(4638785..4639099) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative inner membrane protein 4639099 7150383 ECIAI39_4440 Escherichia coli IAI39 putative inner membrane protein YP_002410313.1 4638785 R 585057 CDS YP_002410314.1 218702685 7150384 complement(4639112..4639795) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative soluble lytic murein transglycosylase 4639795 7150384 ECIAI39_4441 Escherichia coli IAI39 putative soluble lytic murein transglycosylase YP_002410314.1 4639112 R 585057 CDS YP_002410315.1 218702686 7150385 complement(4639720..4640007) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative inner membrane protein 4640007 7150385 ECIAI39_4442 Escherichia coli IAI39 putative inner membrane protein YP_002410315.1 4639720 R 585057 CDS YP_002410316.1 218702687 7150386 complement(4640346..4641566) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase 4641566 7150386 ECIAI39_4443 Escherichia coli IAI39 putative transposase YP_002410316.1 4640346 R 585057 CDS YP_002410317.1 218702688 7150387 complement(4641585..4642103) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4642103 7150387 ECIAI39_4444 Escherichia coli IAI39 hypothetical protein YP_002410317.1 4641585 R 585057 CDS YP_002410318.1 218702689 7150388 4642437..4642784 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7715460; Product type pr : putative regulator; putative transcriptional regulator 4642784 7150388 ECIAI39_4445 Escherichia coli IAI39 putative transcriptional regulator YP_002410318.1 4642437 D 585057 CDS YP_002410319.1 218702690 7150389 complement(4642839..4644188) 1 NC_011750.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase III 4644188 lysC 7150389 lysC Escherichia coli IAI39 aspartate kinase III YP_002410319.1 4642839 R 585057 CDS YP_002410320.1 218702691 7150550 4644713..4646362 1 NC_011750.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 4646362 pgi 7150550 pgi Escherichia coli IAI39 glucose-6-phosphate isomerase YP_002410320.1 4644713 D 585057 CDS YP_002410321.1 218702692 7152381 complement(4646697..4646945) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4646945 7152381 ECIAI39_4448 Escherichia coli IAI39 hypothetical protein YP_002410321.1 4646697 R 585057 CDS YP_002410322.1 218702693 7150390 4647072..4647710 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein 4647710 yjbF 7150390 yjbF Escherichia coli IAI39 putative lipoprotein YP_002410322.1 4647072 D 585057 CDS YP_002410323.1 218702694 7154258 4647707..4648444 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4648444 yjbG 7154258 yjbG Escherichia coli IAI39 hypothetical protein YP_002410323.1 4647707 D 585057 CDS YP_002410324.1 218702695 7154259 4648444..4650540 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative porin 4650540 yjbH 7154259 yjbH Escherichia coli IAI39 putative porin YP_002410324.1 4648444 D 585057 CDS YP_002410325.1 218702696 7154260 4651079..4651489 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10986267; Product type pm : putative membrane component; phosphate-starvation-inducible protein PsiE 4651489 yjbA 7154260 yjbA Escherichia coli IAI39 phosphate-starvation-inducible protein PsiE YP_002410325.1 4651079 D 585057 CDS YP_002410326.1 218702697 7154254 complement(4651583..4652473) 1 NC_011750.1 with MalKFE is involved in the transport of maltose into the cell; maltose transporter permease 4652473 malG 7154254 malG Escherichia coli IAI39 maltose transporter permease YP_002410326.1 4651583 R 585057 CDS YP_002410327.1 218702698 7151997 complement(4652488..4654032) 1 NC_011750.1 with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein 4654032 malF 7151997 malF Escherichia coli IAI39 maltose transporter membrane protein YP_002410327.1 4652488 R 585057 CDS YP_002410328.1 218702699 7151996 complement(4654186..4655376) 1 NC_011750.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter periplasmic protein 4655376 malE 7151996 malE Escherichia coli IAI39 maltose ABC transporter periplasmic protein YP_002410328.1 4654186 R 585057 CDS YP_002410329.1 218702700 7151995 4655741..4656856 1 NC_011750.1 with malEFG is involved in import of maltose/maltodextrin; maltose/maltodextrin transporter ATP-binding protein 4656856 malK 7151995 malK Escherichia coli IAI39 maltose/maltodextrin transporter ATP-binding protein YP_002410329.1 4655741 D 585057 CDS YP_002410330.1 218702701 7151999 4656928..4658268 1 NC_011750.1 porin involved in the transport of maltose and maltodextrins; maltoporin 4658268 lamB 7151999 lamB Escherichia coli IAI39 maltoporin YP_002410330.1 4656928 D 585057 CDS YP_002410331.1 218702702 7151916 4658511..4659431 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87141162, 2434655, 6086106; Product type pt : putative transporter; maltose regulon periplasmic protein 4659431 malM 7151916 malM Escherichia coli IAI39 maltose regulon periplasmic protein YP_002410331.1 4658511 D 585057 CDS YP_002410332.1 218702703 7152000 4659659..4661239 1 NC_011750.1 in E. coli, some yjbl mutations have been reported as suppressors of dnaG mutations; hypothetical protein 4661239 yjbI 7152000 yjbI Escherichia coli IAI39 hypothetical protein YP_002410332.1 4659659 D 585057 CDS YP_002410333.1 218702704 7154261 4661462..4661959 1 NC_011750.1 catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 4661959 ubiC 7154261 ubiC Escherichia coli IAI39 chorismate pyruvate lyase YP_002410333.1 4661462 D 585057 CDS YP_002410334.1 218702705 7153070 4661972..4662844 1 NC_011750.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 4662844 ubiA 7153070 ubiA Escherichia coli IAI39 4-hydroxybenzoate octaprenyltransferase YP_002410334.1 4661972 D 585057 CDS YP_002410335.1 218702706 7153068 complement(4662999..4665422) 1 NC_011750.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 4665422 plsB 7153068 plsB Escherichia coli IAI39 glycerol-3-phosphate acyltransferase YP_002410335.1 4662999 R 585057 CDS YP_002410336.1 218702707 7152427 4665593..4665961 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10220339, 6257698, 86278195, 88111690, 2984194, 6309817, 8071224; Product type e : enzyme; diacylglycerol kinase 4665961 dgkA 7152427 dgkA Escherichia coli IAI39 diacylglycerol kinase YP_002410336.1 4665593 D 585057 CDS YP_002410337.1 218702708 7151125 4666071..4666679 1 NC_011750.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 4666679 lexA 7151125 lexA Escherichia coli IAI39 LexA repressor YP_002410337.1 4666071 D 585057 CDS YP_002410338.1 218702709 7151931 4666698..4668077 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87165788; Product type cp : cell process; DNA-damage-inducible SOS response protein 4668077 dinF 7151931 dinF Escherichia coli IAI39 DNA-damage-inducible SOS response protein YP_002410338.1 4666698 D 585057 CDS YP_002410339.1 218702710 7151139 4668193..4668402 1 NC_011750.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; putative stress-response protein 4668402 yjbJ 7151139 yjbJ Escherichia coli IAI39 putative stress-response protein YP_002410339.1 4668193 D 585057 CDS YP_002410340.1 218702711 7154262 complement(4668444..4668959) 1 NC_011750.1 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor 4668959 zur 7154262 zur Escherichia coli IAI39 zinc uptake transcriptional repressor YP_002410340.1 4668444 R 585057 CDS YP_002410341.1 218702712 7154599 4669277..4670281 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4670281 7154599 ECIAI39_4468 Escherichia coli IAI39 hypothetical protein YP_002410341.1 4669277 D 585057 CDS YP_002410342.1 218702713 7150391 4670643..4671680 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566; Product type e : enzyme; tRNA-dihydrouridine synthase A 4671680 yjbN 7150391 yjbN Escherichia coli IAI39 tRNA-dihydrouridine synthase A YP_002410342.1 4670643 D 585057 CDS YP_002410343.1 218702714 7154263 4671604..4672056 1 NC_011750.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 4672056 pspG 7154263 pspG Escherichia coli IAI39 phage shock protein G YP_002410343.1 4671604 D 585057 CDS YP_002410344.1 218702715 7154264 complement(4672222..4673331) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94089392, 7602590; Product type e : enzyme; quinone oxidoreductase, NADPH-dependent 4673331 qor 7154264 qor Escherichia coli IAI39 quinone oxidoreductase, NADPH-dependent YP_002410344.1 4672222 R 585057 CDS YP_002410345.1 218702716 7152557 4673306..4674721 1 NC_011750.1 unwinds double stranded DNA; replicative DNA helicase 4674721 dnaB 7152557 dnaB Escherichia coli IAI39 replicative DNA helicase YP_002410345.1 4673306 D 585057 CDS YP_002410346.1 218702717 7151154 4674774..4675853 1 NC_011750.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 4675853 alr 7151154 alr Escherichia coli IAI39 alanine racemase YP_002410346.1 4674774 D 585057 CDS YP_002410347.1 218702718 7150718 4676106..4677299 1 NC_011750.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 4677299 tyrB 7150718 tyrB Escherichia coli IAI39 aromatic amino acid aminotransferase YP_002410347.1 4676106 D 585057 CDS YP_002410348.1 218702719 7153063 complement(4677522..4678061) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4678061 7153063 ECIAI39_4475 Escherichia coli IAI39 hypothetical protein YP_002410348.1 4677522 R 585057 CDS YP_002410349.1 218702720 7150392 4678426..4679139 1 NC_011750.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 4679139 aphA 7150392 aphA Escherichia coli IAI39 acid phosphatase/phosphotransferase YP_002410349.1 4678426 D 585057 CDS YP_002410350.1 218702721 7150741 4679250..4679666 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11972052; hypothetical protein 4679666 yjbQ 7150741 yjbQ Escherichia coli IAI39 hypothetical protein YP_002410350.1 4679250 D 585057 CDS YP_002410351.1 218702722 7154265 4679670..4680026 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4680026 yjbR 7154265 yjbR Escherichia coli IAI39 hypothetical protein YP_002410351.1 4679670 D 585057 CDS YP_002410352.1 218702723 7154266 complement(4680061..4682883) 1 NC_011750.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 4682883 uvrA 7154266 uvrA Escherichia coli IAI39 excinuclease ABC subunit A YP_002410352.1 4680061 R 585057 CDS YP_002410353.1 218702724 7153113 4683138..4683674 1 NC_011750.1 binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 4683674 ssb 7153113 ssb Escherichia coli IAI39 single-stranded DNA-binding protein YP_002410353.1 4683138 D 585057 CDS YP_002410354.1 218702725 7152902 complement(4683773..4684054) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4684054 yjcB 7152902 yjcB Escherichia coli IAI39 hypothetical protein YP_002410354.1 4683773 R 585057 CDS YP_002410355.1 218702726 7154267 4684484..4686070 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative signal transduction protein 4686070 yjcC 7154267 yjcC Escherichia coli IAI39 putative signal transduction protein YP_002410355.1 4684484 D 585057 CDS YP_002410356.1 218702727 7154268 complement(4686073..4686396) 1 NC_011750.1 regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS 4686396 soxS 7154268 soxS Escherichia coli IAI39 DNA-binding transcriptional regulator SoxS YP_002410356.1 4686073 R 585057 CDS YP_002410357.1 218702728 7152878 4686482..4686946 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91210176, 91360349, 94139656, 9564045, 10207625, 12670967, 1653416, 1708380, 7673113, 8065907, 8306957, 8631739, 8969171, 9019397, 9092651, 9204707; Product type r : regulator; DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing 4686946 soxR 7152878 soxR Escherichia coli IAI39 DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing YP_002410357.1 4686482 D 585057 CDS YP_002410358.1 218702729 7152794 4687492..4688841 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease 4688841 yjcD 7152794 yjcD Escherichia coli IAI39 putative permease YP_002410358.1 4687492 D 585057 CDS YP_002410359.1 218702730 7154269 4688992..4690641 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 21557160, 11479290; Product type pt : putative transporter; putative cation/proton antiporter 4690641 yjcE 7154269 yjcE Escherichia coli IAI39 putative cation/proton antiporter YP_002410359.1 4688992 D 585057 CDS YP_002410360.1 218702731 7154270 complement(4690723..4692372) 1 NC_011750.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease 4692372 actP 7154270 actP Escherichia coli IAI39 acetate permease YP_002410360.1 4690723 R 585057 CDS YP_002410361.1 218702732 7150681 complement(4692369..4692896) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4692896 7150681 ECIAI39_4488 Escherichia coli IAI39 hypothetical protein YP_002410361.1 4692369 R 585057 CDS YP_002410362.1 218702733 7150393 4692929..4693459 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 4693459 7150393 ECIAI39_4489 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002410362.1 4692929 D 585057 CDS YP_002410363.1 218702734 7150394 4693564..4694286 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 4694286 7150394 ECIAI39_4490 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002410363.1 4693564 D 585057 CDS YP_002410364.1 218702735 7150395 complement(4694345..4696303) 1 NC_011750.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 4696303 acs 7150395 acs Escherichia coli IAI39 acetyl-CoA synthetase YP_002410364.1 4694345 R 585057 CDS YP_002410365.1 218702736 7150680 4696696..4698132 1 NC_011750.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 4698132 nrfA 7150680 nrfA Escherichia coli IAI39 cytochrome c552 YP_002410365.1 4696696 D 585057 CDS YP_002410366.1 218702737 7152253 4698178..4698744 1 NC_011750.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 4698744 nrfB 7152253 nrfB Escherichia coli IAI39 cytochrome c nitrite reductase pentaheme subunit YP_002410366.1 4698178 D 585057 CDS YP_002410367.1 218702738 7152254 4698741..4699412 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94335626, 8057835; Product type c : carrier; formate-dependent nitrite reductase, 4Fe4S subunit 4699412 nrfC 7152254 nrfC Escherichia coli IAI39 formate-dependent nitrite reductase, 4Fe4S subunit YP_002410367.1 4698741 D 585057 CDS YP_002410368.1 218702739 7152255 4699409..4700365 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 8057835; Product type e : enzyme; formate-dependent nitrite reductase, membrane subunit 4700365 nrfD 7152255 nrfD Escherichia coli IAI39 formate-dependent nitrite reductase, membrane subunit YP_002410368.1 4699409 D 585057 CDS YP_002410369.1 218702740 7152256 4700445..4702103 1 NC_011750.1 with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 4702103 nrfE 7152256 nrfE Escherichia coli IAI39 heme lyase subunit NrfE YP_002410369.1 4700445 D 585057 CDS YP_002410370.1 218702741 7152257 4702096..4702479 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 9593308, 8057835, 8842153; Product type f : factor; formate-dependent nitrite reductase complex subunit NrfF 4702479 nrfF 7152257 nrfF Escherichia coli IAI39 formate-dependent nitrite reductase complex subunit NrfF YP_002410370.1 4702096 D 585057 CDS YP_002410371.1 218702742 7152258 4702476..4703072 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 9593308, 8057835, 8842153; Product type f : factor; formate-dependent nitrite reductase complex subunit NrfG 4703072 nrfG 7152258 nrfG Escherichia coli IAI39 formate-dependent nitrite reductase complex subunit NrfG YP_002410371.1 4702476 D 585057 CDS YP_002410372.1 218702743 7152259 4703414..4704727 1 NC_011750.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 4704727 gltP 7152259 gltP Escherichia coli IAI39 glutamate/aspartate:proton symporter YP_002410372.1 4703414 D 585057 CDS YP_002410373.1 218702744 7151555 complement(4704806..4705495) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4705495 yjcO 7151555 yjcO Escherichia coli IAI39 hypothetical protein YP_002410373.1 4704806 R 585057 CDS YP_002410374.1 218702745 7154271 complement(4705589..4707736) 1 NC_011750.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-H, selenopolypeptide subunit 4707736 fdhF 7154271 fdhF Escherichia coli IAI39 formate dehydrogenase-H, selenopolypeptide subunit YP_002410374.1 4705589 R 585057 CDS YP_002410375.1 218702746 7151285 complement(4707934..4709400) 1 NC_011750.1 part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; putative outer membrane efflux protein MdtP 4709400 yjcP 7151285 yjcP Escherichia coli IAI39 putative outer membrane efflux protein MdtP YP_002410375.1 4707934 R 585057 CDS YP_002410376.1 218702747 7154272 complement(4709397..4711448) 1 NC_011750.1 possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO 4711448 yjcQ 7154272 yjcQ Escherichia coli IAI39 multidrug efflux system protein MdtO YP_002410376.1 4709397 R 585057 CDS YP_002410377.1 218702748 7154273 complement(4711448..4712479) 1 NC_011750.1 with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN 4712479 yjcR 7154273 yjcR Escherichia coli IAI39 multidrug resistance protein MdtN YP_002410377.1 4711448 R 585057 CDS YP_002410378.1 218702749 7150396 complement(4712982..4714967) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1587481; Product type pe : putative enzyme; putative alkyl sulfatase 4714967 yjcS 7150396 yjcS Escherichia coli IAI39 putative alkyl sulfatase YP_002410378.1 4712982 R 585057 CDS YP_002410379.1 218702750 7154275 complement(4715240..4716169) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20026827, 9401019; Product type e : enzyme; D-allose kinase 4716169 alsK 7154275 alsK Escherichia coli IAI39 D-allose kinase YP_002410379.1 4715240 R 585057 CDS YP_002410380.1 218702751 7150723 complement(4716153..4716848) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20026827, 9401019; Product type e : enzyme; allulose-6-phosphate 3-epimerase 4716848 alsE 7150723 alsE Escherichia coli IAI39 allulose-6-phosphate 3-epimerase YP_002410380.1 4716153 R 585057 CDS YP_002410381.1 218702752 7150722 complement(4716859..4717839) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20026827, 9401019; Product type t : transporter; D-allose transporter subunit 4717839 alsC 7150722 alsC Escherichia coli IAI39 D-allose transporter subunit YP_002410381.1 4716859 R 585057 CDS YP_002410382.1 218702753 7150721 complement(4717818..4719350) 1 NC_011750.1 with AlsBC acts to import allose into the cell; AlsA contain 2 ATP-binding domains; D-allose transporter ATP-binding protein 4719350 alsA 7150721 alsA Escherichia coli IAI39 D-allose transporter ATP-binding protein YP_002410382.1 4717818 R 585057 CDS YP_002410383.1 218702754 7150719 complement(4719477..4720412) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20026827, 9401019, 10064713, 8576032; Product type t : transporter; D-allose transporter subunit 4720412 alsB 7150719 alsB Escherichia coli IAI39 D-allose transporter subunit YP_002410383.1 4719477 R 585057 CDS YP_002410384.1 218702755 7150720 complement(4720471..4721361) 1 NC_011750.1 involved in rpiB and als operon repression; DNA-binding transcriptional repressor RpiR 4721361 rpiR 7150720 rpiR Escherichia coli IAI39 DNA-binding transcriptional repressor RpiR YP_002410384.1 4720471 R 585057 CDS YP_002410385.1 218702756 7152670 4721721..4722170 1 NC_011750.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B 4722170 rpiB 7152670 rpiB Escherichia coli IAI39 ribose-5-phosphate isomerase B YP_002410385.1 4721721 D 585057 CDS YP_002410386.1 218702757 7152669 4722239..4722577 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4722577 yjdP 7152669 yjdP Escherichia coli IAI39 hypothetical protein YP_002410386.1 4722239 D 585057 CDS YP_002410387.1 218702758 7154285 complement(4722612..4723370) 1 NC_011750.1 required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein 4723370 phnP 7154285 phnP Escherichia coli IAI39 carbon-phosphorus lyase complex accessory protein YP_002410387.1 4722612 R 585057 CDS YP_002410388.1 218702759 7152408 complement(4723372..4723806) 1 NC_011750.1 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase 4723806 phnO 7152408 phnO Escherichia coli IAI39 aminoalkylphosphonic acid N-acetyltransferase YP_002410388.1 4723372 R 585057 CDS YP_002410389.1 218702760 7152407 complement(4723793..4724350) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12700258, 91100346, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; ribose 1,5-bisphosphokinase 4724350 phnN 7152407 phnN Escherichia coli IAI39 ribose 1,5-bisphosphokinase YP_002410389.1 4723793 R 585057 CDS YP_002410390.1 218702761 7152406 complement(4724350..4725486) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100346, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4725486 phnM 7152406 phnM Escherichia coli IAI39 carbon-phosphorus lyase complex subunit YP_002410390.1 4724350 R 585057 CDS YP_002410391.1 218702762 7152405 complement(4725483..4726163) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4726163 phnL 7152405 phnL Escherichia coli IAI39 carbon-phosphorus lyase complex subunit YP_002410391.1 4725483 R 585057 CDS YP_002410392.1 218702763 7152404 complement(4726342..4727100) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; phosphonate C-P lyase system protein PhnK 4727100 phnK 7152404 phnK Escherichia coli IAI39 phosphonate C-P lyase system protein PhnK YP_002410392.1 4726342 R 585057 CDS YP_002410393.1 218702764 7152403 complement(4727097..4727942) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4727942 phnJ 7152403 phnJ Escherichia coli IAI39 carbon-phosphorus lyase complex subunit YP_002410393.1 4727097 R 585057 CDS YP_002410394.1 218702765 7152402 complement(4727935..4728999) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4728999 phnI 7152402 phnI Escherichia coli IAI39 carbon-phosphorus lyase complex subunit YP_002410394.1 4727935 R 585057 CDS YP_002410395.1 218702766 7152401 complement(4728999..4729583) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4729583 phnH 7152401 phnH Escherichia coli IAI39 carbon-phosphorus lyase complex subunit YP_002410395.1 4728999 R 585057 CDS YP_002410396.1 218702767 7152400 complement(4729580..4730032) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4730032 phnG 7152400 phnG Escherichia coli IAI39 carbon-phosphorus lyase complex subunit YP_002410396.1 4729580 R 585057 CDS YP_002410397.1 218702768 7152399 complement(4730033..4730758) 1 NC_011750.1 may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF 4730758 phnF 7152399 phnF Escherichia coli IAI39 phosphonate metabolism transcriptional regulator PhnF YP_002410397.1 4730033 R 585057 CDS YP_002410398.1 218702769 7152398 complement(4730779..4731558) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; phosphonates transport system permease 4731558 phnE 7152398 phnE Escherichia coli IAI39 phosphonates transport system permease YP_002410398.1 4730779 R 585057 CDS YP_002410399.1 218702770 7152397 complement(4731623..4732639) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type t : transporter; phosphonate/organophosphate ester ABC transporter periplasmic binding protein 4732639 phnD 7152397 phnD Escherichia coli IAI39 phosphonate/organophosphate ester ABC transporter periplasmic binding protein YP_002410399.1 4731623 R 585057 CDS YP_002410400.1 218702771 7152396 complement(4732664..4733386) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type t : transporter; phosphonate/organophosphate ester ABC transporter ATP-binding protein 4733386 phnC 7152396 phnC Escherichia coli IAI39 phosphonate/organophosphate ester ABC transporter ATP-binding protein YP_002410400.1 4732664 R 585057 CDS YP_002410401.1 218702772 7152394 complement(4734122..4734604) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9650256, 2155230; Product type pt : putative transporter; putative alkylphosphonate uptake protein in phosphonate metabolism 4734604 7152394 ECIAI39_4531 Escherichia coli IAI39 putative alkylphosphonate uptake protein in phosphonate metabolism YP_002410401.1 4734122 R 585057 CDS YP_002410402.1 218702773 7150397 4734858..4737086 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4737086 yjdA 7150397 yjdA Escherichia coli IAI39 hypothetical protein YP_002410402.1 4734858 D 585057 CDS YP_002410403.1 218702774 7154277 4737083..4737961 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4737961 yjcZ 7154277 yjcZ Escherichia coli IAI39 hypothetical protein YP_002410403.1 4737083 D 585057 CDS YP_002410404.1 218702775 7154276 4738225..4739727 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10049386, 12525168, 92165733, 93132799, 9871325, 99376621, 8421314; Product type t : transporter; proline/glycine betaine transporter 4739727 proP 7154276 proP Escherichia coli IAI39 proline/glycine betaine transporter YP_002410404.1 4738225 D 585057 CDS YP_002410405.1 218702776 7152486 complement(4739904..4741004) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94110256, 8282725; Product type r : regulator; sensor protein BasS/PmrB 4741004 basS 7152486 basS Escherichia coli IAI39 sensor protein BasS/PmrB YP_002410405.1 4739904 R 585057 CDS YP_002410406.1 218702777 7150839 complement(4741005..4741673) 1 NC_011750.1 response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR 4741673 basR 7150839 basR Escherichia coli IAI39 DNA-binding transcriptional regulator BasR YP_002410406.1 4741005 R 585057 CDS YP_002410407.1 218702778 7150838 complement(4741670..4743313) 1 NC_011750.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; putative cell division protein 4743313 eptA 7150838 eptA Escherichia coli IAI39 putative cell division protein YP_002410407.1 4741670 R 585057 CDS YP_002410408.1 218702779 7151236 complement(4743417..4744754) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12867448; Product type t : transporter; arginine:agmatin antiporter 4744754 adiC 7151236 adiC Escherichia coli IAI39 arginine:agmatin antiporter YP_002410408.1 4743417 R 585057 CDS YP_002410409.1 218702780 7150690 complement(4744891..4745652) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : c; Product type r : regulator; DNA-binding transcriptional activator 4745652 adiY 7150690 adiY Escherichia coli IAI39 DNA-binding transcriptional activator YP_002410409.1 4744891 R 585057 CDS YP_002410410.1 218702781 7150691 complement(4745988..4748258) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93186686, 2830169, 4204273, 8383109; Product type e : enzyme; biodegradative arginine decarboxylase 4748258 adiA 7150691 adiA Escherichia coli IAI39 biodegradative arginine decarboxylase YP_002410410.1 4745988 R 585057 CDS YP_002410411.1 218702782 7150689 complement(4748454..4749362) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90060832, 9108148, 1445207, 2684786, 2830169; Product type r : regulator; DNA-binding transcriptional regulator MelR 4749362 melR 7150689 melR Escherichia coli IAI39 DNA-binding transcriptional regulator MelR YP_002410411.1 4748454 R 585057 CDS YP_002410412.1 218702783 7152042 4749645..4751000 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87174747, 88162811, 90248411, 2831880, 3031590, 6329200; Product type e : enzyme; alpha-galactosidase, NAD(P)-binding 4751000 melA 7152042 melA Escherichia coli IAI39 alpha-galactosidase, NAD(P)-binding YP_002410412.1 4749645 D 585057 CDS YP_002410413.1 218702784 7152040 4751115..4752524 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14757226, 90241878, 92297631, 93155159, 1730719, 1872836, 6323466, 8672452; Product type t : transporter; melibiose:sodium symporter 4752524 melB 7152040 melB Escherichia coli IAI39 melibiose:sodium symporter YP_002410413.1 4751115 D 585057 CDS YP_002410414.1 218702785 7152041 complement(4752663..4753292) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4753292 yjdF 7152041 yjdF Escherichia coli IAI39 hypothetical protein YP_002410414.1 4752663 R 585057 CDS YP_002410415.1 218702786 7154279 complement(4753415..4755061) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86142617, 88193096, 89255123, 2656658; Product type e : enzyme; anaerobic class I fumarate hydratase 4755061 fumB 7154279 fumB Escherichia coli IAI39 anaerobic class I fumarate hydratase YP_002410415.1 4753415 R 585057 CDS YP_002410416.1 218702787 7151454 complement(4755139..4756479) 1 NC_011750.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter 4756479 dcuB 7151454 dcuB Escherichia coli IAI39 anaerobic C4-dicarboxylate transporter YP_002410416.1 4755139 R 585057 CDS YP_002410417.1 218702788 7151096 complement(4757050..4757769) 1 NC_011750.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR 4757769 dcuR 7151096 dcuR Escherichia coli IAI39 DNA-binding transcriptional activator DcuR YP_002410417.1 4757050 R 585057 CDS YP_002410418.1 218702789 7151099 complement(4757766..4759397) 1 NC_011750.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS 4759397 dcuS 7151099 dcuS Escherichia coli IAI39 sensory histidine kinase DcuS YP_002410418.1 4757766 R 585057 CDS YP_002410419.1 218702790 7151100 4759578..4759808 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4759808 yjdI 7151100 yjdI Escherichia coli IAI39 hypothetical protein YP_002410419.1 4759578 D 585057 CDS YP_002410420.1 218702791 7154280 4759820..4760092 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA N-acyltransferase domain-containing acyltransferase 4760092 yjdJ 7154280 yjdJ Escherichia coli IAI39 putative acyl-CoA N-acyltransferase domain-containing acyltransferase YP_002410420.1 4759820 D 585057 CDS YP_002410421.1 218702792 7154281 4760321..4760617 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4760617 yjdK 7154281 yjdK Escherichia coli IAI39 hypothetical protein YP_002410421.1 4760321 D 585057 CDS YP_002410422.1 218702793 7154282 4760645..4760818 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4760818 yjdO 7154282 yjdO Escherichia coli IAI39 hypothetical protein YP_002410422.1 4760645 D 585057 CDS YP_002410423.1 218702794 7154284 complement(4760937..4762454) 1 NC_011750.1 class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 4762454 lysU 7154284 lysU Escherichia coli IAI39 lysyl-tRNA synthetase YP_002410423.1 4760937 R 585057 CDS YP_002410424.1 218702795 7151987 complement(4762691..4764061) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4764061 yjdL 7151987 yjdL Escherichia coli IAI39 putative transporter YP_002410424.1 4762691 R 585057 CDS YP_002410425.1 218702796 7154283 complement(4764202..4766349) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92105022, 92210511, 1370290, 1556085, 4204273; Product type e : enzyme; lysine decarboxylase 1 4766349 cadA 7154283 cadA Escherichia coli IAI39 lysine decarboxylase 1 YP_002410425.1 4764202 R 585057 CDS YP_002410426.1 218702797 7150891 complement(4766429..4767763) 1 NC_011750.1 antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein; lysine/cadaverine antiporter 4767763 cadB 7150891 cadB Escherichia coli IAI39 lysine/cadaverine antiporter YP_002410426.1 4766429 R 585057 CDS YP_002410427.1 218702798 7150892 complement(4768129..4769667) 1 NC_011750.1 regulates the cadBA operon; DNA-binding transcriptional activator CadC 4769667 cadC 7150892 cadC Escherichia coli IAI39 DNA-binding transcriptional activator CadC YP_002410427.1 4768129 R 585057 CDS YP_002410428.1 218702799 7150893 complement(4770471..4771319) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4771319 7150893 ECIAI39_4563 Escherichia coli IAI39 hypothetical protein YP_002410428.1 4770471 R 585057 CDS YP_002410429.1 218702800 7150398 4771394..4771720 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 4771720 7150398 ECIAI39_4564 Escherichia coli IAI39 transposase ORF A, IS629 YP_002410429.1 4771394 D 585057 CDS YP_002410430.1 218702801 7150399 4771720..4772607 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 4772607 7150399 ECIAI39_4565 Escherichia coli IAI39 transposase ORF B, IS629 YP_002410430.1 4771720 D 585057 CDS YP_002410431.1 218702802 7150400 complement(4772610..4772873) 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4772873 7150400 ECIAI39_4566 Escherichia coli IAI39 hypothetical protein YP_002410431.1 4772610 R 585057 CDS YP_002410432.1 218702803 7150401 complement(4772944..4773789) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9987116; hypothetical protein 4773789 7150401 ECIAI39_4567 Escherichia coli IAI39 hypothetical protein YP_002410432.1 4772944 R 585057 CDS YP_002410433.1 218702804 7150402 complement(4773874..4774122) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4774122 7150402 ECIAI39_4568 Escherichia coli IAI39 hypothetical protein YP_002410433.1 4773874 R 585057 CDS YP_002410434.1 218702805 7150403 complement(4774089..4774577) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4774577 yeeW 7150403 yeeW Escherichia coli IAI39 hypothetical protein YP_002410434.1 4774089 R 585057 CDS YP_002410435.1 218702806 7153729 complement(4774574..4774951) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; toxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage 4774951 yeeV 7153729 yeeV Escherichia coli IAI39 toxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage YP_002410435.1 4774574 R 585057 CDS YP_002410436.1 218702807 7153723 complement(4775486..4775707) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 4775707 yeeT 7153723 yeeT Escherichia coli IAI39 hypothetical protein YP_002410436.1 4775486 R 585057 CDS YP_002410437.1 218702808 7153720 complement(4775770..4776216) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : putative factor; putative DNA repair protein; CP4-44 prophage 4776216 yeeS 7153720 yeeS Escherichia coli IAI39 putative DNA repair protein; CP4-44 prophage YP_002410437.1 4775770 R 585057 CDS YP_002410438.1 218702809 7153717 complement(4776261..4776746) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative antirestriction protein 4776746 7153717 ECIAI39_4574 Escherichia coli IAI39 putative antirestriction protein YP_002410438.1 4776261 R 585057 CDS YP_002410439.1 218702810 7150404 complement(4776837..4777655) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4777655 7150404 ECIAI39_4575 Escherichia coli IAI39 hypothetical protein YP_002410439.1 4776837 R 585057 CDS YP_002410440.1 218702811 7150405 complement(4777745..4777978) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4777978 7150405 ECIAI39_4576 Escherichia coli IAI39 hypothetical protein YP_002410440.1 4777745 R 585057 CDS YP_002410441.1 218702812 7150406 complement(4777984..4778766) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4778766 7150406 ECIAI39_4577 Escherichia coli IAI39 hypothetical protein YP_002410441.1 4777984 R 585057 CDS YP_002410442.1 218702813 7150407 complement(4779518..4779673) 1 NC_011750.1 hypothetical protein 4779673 7150407 ECIAI39_4578 Escherichia coli IAI39 hypothetical protein YP_002410442.1 4779518 R 585057 CDS YP_002410443.1 218702814 7150408 complement(4779692..4780576) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative GTPase 4780576 7150408 ECIAI39_4579 Escherichia coli IAI39 putative GTPase YP_002410443.1 4779692 R 585057 CDS YP_002410444.1 218702815 7150409 4780677..4781900 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4781900 7150409 ECIAI39_4580 Escherichia coli IAI39 hypothetical protein YP_002410444.1 4780677 D 585057 CDS YP_002410445.1 218702816 7150410 4782894..4783220 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 4783220 7150410 ECIAI39_4581 Escherichia coli IAI39 transposase ORF A, IS629 YP_002410445.1 4782894 D 585057 CDS YP_002410446.1 218702817 7150411 4783217..4784107 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 4784107 7150411 ECIAI39_4582 Escherichia coli IAI39 transposase ORF B, IS629 YP_002410446.1 4783217 D 585057 CDS YP_002410447.1 218702818 7150412 4784164..4784337 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4784337 7150412 ECIAI39_4583 Escherichia coli IAI39 hypothetical protein YP_002410447.1 4784164 D 585057 CDS YP_002410448.1 218702819 7150413 complement(4784680..4784913) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2868893, 1357526; Product type r : regulator; pap operon regulatory protein PapI 4784913 papI 7150413 papI Escherichia coli IAI39 pap operon regulatory protein PapI YP_002410448.1 4784680 R 585057 CDS YP_002410449.1 218702820 7152344 4785188..4785358 1 NC_011750.1 hypothetical protein 4785358 7152344 ECIAI39_4585 Escherichia coli IAI39 hypothetical protein YP_002410449.1 4785188 D 585057 CDS YP_002410450.1 218702821 7150414 4785345..4785659 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2656260, 2868893; Product type r : regulator; pap operon regulatory protein PapB 4785659 papB 7150414 papB Escherichia coli IAI39 pap operon regulatory protein PapB YP_002410450.1 4785345 D 585057 CDS YP_002410451.1 218702822 7152332 4785833..4786429 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6140260, 1357526, 10049807; Product type s : structure; major pilin protein PapA 4786429 papA 7152332 papA Escherichia coli IAI39 major pilin protein PapA YP_002410451.1 4785833 D 585057 CDS YP_002410452.1 218702823 7152330 4786493..4787080 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2882856, 1357526, 2897064; Product type s : structure; minor pilin protein PapH 4787080 papH 7152330 papH Escherichia coli IAI39 minor pilin protein PapH YP_002410452.1 4786493 D 585057 CDS YP_002410453.1 218702824 7152342 4787118..4789649 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2897064, 1357526, 12399496, 2572580, 7909802, 9501230; Product type f : factor; outer membrane usher protein PapC 4789649 papC 7152342 papC Escherichia coli IAI39 outer membrane usher protein PapC YP_002410453.1 4787118 D 585057 CDS YP_002410454.1 218702825 7152333 4789720..4790454 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1357526, 10049807, 2478891, 10446050; Product type f : factor; Chaperone protein PapD 4790454 papD 7152333 papD Escherichia coli IAI39 Chaperone protein PapD YP_002410454.1 4789720 D 585057 CDS YP_002410455.1 218702826 7152334 4790491..4791072 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1975085, 1357526; Product type f : factor; P pilus assembly protein PapJ 4791072 papJ 7152334 papJ Escherichia coli IAI39 P pilus assembly protein PapJ YP_002410455.1 4790491 D 585057 CDS YP_002410456.1 218702827 7152345 4791079..4791618 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1357526, 8096174, 10049807, 10446050; Product type s : structure; fimbrial adapter PapK 4791618 papK 7152345 papK Escherichia coli IAI39 fimbrial adapter PapK YP_002410456.1 4791079 D 585057 CDS YP_002410457.1 218702828 7152346 4791627..4792166 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2869489, 2895103, 1357526, 10049807; Product type s : structure; fimbrial tip protein PapE 4792166 papE 7152346 papE Escherichia coli IAI39 fimbrial tip protein PapE YP_002410457.1 4791627 D 585057 CDS YP_002410458.1 218702829 7152336 4792241..4792741 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2869489, 2895103, 1357526, 8096174, 10049807; Product type s : structure; fimbrial adapter PapF 4792741 papF 7152336 papF Escherichia coli IAI39 fimbrial adapter PapF YP_002410458.1 4792241 D 585057 CDS YP_002410459.1 218702830 7152338 4792785..4793795 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1357526, 2895103, 11440716; Product type s : structure; fimbrial PapG protein 4793795 papG 7152338 papG Escherichia coli IAI39 fimbrial PapG protein YP_002410459.1 4792785 D 585057 CDS YP_002410460.1 218702831 7152341 4794146..4794901 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8675335, 16369033; Product type f : factor; Tia invasion determinant 4794901 tia 7152341 tia Escherichia coli IAI39 Tia invasion determinant YP_002410460.1 4794146 D 585057 CDS YP_002410461.1 218702832 7152984 4795076..4796575 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated, metal-dependent hydrolase 4796575 7152984 ECIAI39_4597 Escherichia coli IAI39 putative membrane-associated, metal-dependent hydrolase YP_002410461.1 4795076 D 585057 CDS YP_002410462.1 218702833 7150415 complement(4796684..4800211) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative superfamily I DNA helicase 4800211 7150415 ECIAI39_4598 Escherichia coli IAI39 putative superfamily I DNA helicase YP_002410462.1 4796684 R 585057 CDS YP_002410463.1 218702834 7150416 complement(4800651..4801913) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Prophage integrase 4801913 int 7150416 int Escherichia coli IAI39 Prophage integrase YP_002410463.1 4800651 R 585057 CDS YP_002410464.1 218702835 7150588 complement(4802293..4802868) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1370290; Product type pr : putative regulator; putative transcriptional regulator 4802868 yjdC 7150588 yjdC Escherichia coli IAI39 putative transcriptional regulator YP_002410464.1 4802293 R 585057 CDS YP_002410465.1 218702836 7154278 complement(4802905..4804602) 1 NC_011750.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein 4804602 dipZ 7154278 dipZ Escherichia coli IAI39 thiol:disulfide interchange protein YP_002410465.1 4802905 R 585057 CDS YP_002410466.1 218702837 7151143 complement(4804578..4804916) 1 NC_011750.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA 4804916 cutA 7151143 cutA Escherichia coli IAI39 divalent-cation tolerance protein CutA YP_002410466.1 4804578 R 585057 CDS YP_002410467.1 218702838 7151034 complement(4805032..4806333) 1 NC_011750.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 4806333 dcuA 7151034 dcuA Escherichia coli IAI39 anaerobic C4-dicarboxylate transporter YP_002410467.1 4805032 R 585057 CDS YP_002410468.1 218702839 7151095 complement(4806451..4807887) 1 NC_011750.1 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 4807887 aspA 7151095 aspA Escherichia coli IAI39 aspartate ammonia-lyase YP_002410468.1 4806451 R 585057 CDS YP_002410469.1 218702840 7150806 4808224..4808700 1 NC_011750.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 4808700 fxsA 7150806 fxsA Escherichia coli IAI39 FxsA protein YP_002410469.1 4808224 D 585057 CDS YP_002410470.1 218702841 7151458 complement(4808716..4809972) 1 NC_011750.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function; inner membrane protein YjeH 4809972 yjeH 7151458 yjeH Escherichia coli IAI39 inner membrane protein YjeH YP_002410470.1 4808716 R 585057 CDS YP_002410471.1 218702842 7154288 4810248..4810541 1 NC_011750.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 4810541 groES 7154288 groES Escherichia coli IAI39 co-chaperonin GroES YP_002410471.1 4810248 D 585057 CDS YP_002410472.1 218702843 7151586 4810585..4812231 1 NC_011750.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 4812231 groEL 7151586 groEL Escherichia coli IAI39 chaperonin GroEL YP_002410472.1 4810585 D 585057 CDS YP_002410473.1 218702844 7151585 4812366..4812719 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4812719 yjeI 7151585 yjeI Escherichia coli IAI39 hypothetical protein YP_002410473.1 4812366 D 585057 CDS YP_002410474.1 218702845 7154289 complement(4812769..4813638) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4813638 yjeJ 7154289 yjeJ Escherichia coli IAI39 hypothetical protein YP_002410474.1 4812769 R 585057 CDS YP_002410475.1 218702846 7154290 complement(4813873..4814901) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019591, 10629195; Product type pe : putative enzyme; putative lysine aminomutase 4814901 yjeK 7154290 yjeK Escherichia coli IAI39 putative lysine aminomutase YP_002410475.1 4813873 R 585057 CDS YP_002410476.1 218702847 7154291 4814943..4815509 1 NC_011750.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 4815509 efp 7154291 efp Escherichia coli IAI39 elongation factor P YP_002410476.1 4814943 D 585057 CDS YP_002410477.1 218702848 7151207 complement(4815759..4816262) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 4816262 insB 7151207 insB Escherichia coli IAI39 IS1 transposase InsAB' YP_002410477.1 4815759 R 585057 CDS YP_002410478.1 218702849 7151800 complement(4816181..4816456) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 4816456 insA 7151800 insA Escherichia coli IAI39 IS1 repressor protein InsA YP_002410478.1 4816181 R 585057 CDS YP_002410479.1 218702850 7151789 4816895..4817212 1 NC_011750.1 member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations; quaternary ammonium compound-resistance protein SugE 4817212 sugE 7151789 sugE Escherichia coli IAI39 quaternary ammonium compound-resistance protein SugE YP_002410479.1 4816895 D 585057 CDS YP_002410480.1 218702851 7152929 complement(4817209..4817742) 1 NC_011750.1 lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc 4817742 blc 7152929 blc Escherichia coli IAI39 outer membrane lipoprotein Blc YP_002410480.1 4817209 R 585057 CDS YP_002410481.1 218702852 7150871 complement(4817830..4818963) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92212899, 97464439, 99421326, 10595535, 6795623, 7041115, 9819201; Product type e : enzyme; beta-lactamase 4818963 ampC 7150871 ampC Escherichia coli IAI39 beta-lactamase YP_002410481.1 4817830 R 585057 CDS YP_002410482.1 218702853 7150729 complement(4819026..4819385) 1 NC_011750.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 4819385 frdD 7150729 frdD Escherichia coli IAI39 fumarate reductase subunit D YP_002410482.1 4819026 R 585057 CDS YP_002410483.1 218702854 7151411 complement(4819396..4819791) 1 NC_011750.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C 4819791 frdC 7151411 frdC Escherichia coli IAI39 fumarate reductase subunit C YP_002410483.1 4819396 R 585057 CDS YP_002410484.1 218702855 7151410 complement(4819802..4820536) 1 NC_011750.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit 4820536 frdB 7151410 frdB Escherichia coli IAI39 fumarate reductase iron-sulfur subunit YP_002410484.1 4819802 R 585057 CDS YP_002410485.1 218702856 7151409 complement(4820529..4822337) 1 NC_011750.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 4822337 frdA 7151409 frdA Escherichia coli IAI39 fumarate reductase flavoprotein subunit YP_002410485.1 4820529 R 585057 CDS YP_002410486.1 218702857 7151408 4822662..4823639 1 NC_011750.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 4823639 poxA 7151408 poxA Escherichia coli IAI39 lysyl-tRNA synthetase YP_002410486.1 4822662 D 585057 CDS YP_002410487.1 218702858 7152450 4823858..4825360 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4825360 yjeM 7152450 yjeM Escherichia coli IAI39 putative transporter YP_002410487.1 4823858 D 585057 CDS YP_002410488.1 218702859 7154292 complement(4825511..4828834) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 4828834 yjeP 7154292 yjeP Escherichia coli IAI39 hypothetical protein YP_002410488.1 4825511 R 585057 CDS YP_002410489.1 218702860 7154293 complement(4828856..4829824) 1 NC_011750.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 4829824 psd 7154293 psd Escherichia coli IAI39 phosphatidylserine decarboxylase YP_002410489.1 4828856 R 585057 CDS YP_002410490.1 218702861 7152500 complement(4829921..4830973) 1 NC_011750.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 4830973 rsgA 7152500 rsgA Escherichia coli IAI39 ribosome-associated GTPase YP_002410490.1 4829921 R 585057 CDS YP_002410491.1 218702862 7152742 4831068..4831613 1 NC_011750.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4831613 orn 7152742 orn Escherichia coli IAI39 oligoribonuclease YP_002410491.1 4831068 D 585057 CDS YP_002410492.1 218702863 7150582 complement(4832392..4833531) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative Fe-S electron transport protein 4833531 yjeS 7150582 yjeS Escherichia coli IAI39 putative Fe-S electron transport protein YP_002410492.1 4832392 R 585057 CDS YP_002410493.1 218702864 7154294 4833530..4835077 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 4835077 yjeF 7154294 yjeF Escherichia coli IAI39 hypothetical protein YP_002410493.1 4833530 D 585057 CDS YP_002410494.1 218702865 7154287 4835049..4835510 1 NC_011750.1 possibly involved in cell wall synthesis; putative ATPase 4835510 yjeE 7154287 yjeE Escherichia coli IAI39 putative ATPase YP_002410494.1 4835049 D 585057 CDS YP_002410495.1 218702866 7154286 4835529..4836866 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21348478, 87242501, 1594459, 7511774; Product type e : enzyme; N-acetylmuramoyl-l-alanine amidase II 4836866 amiB 7154286 amiB Escherichia coli IAI39 N-acetylmuramoyl-l-alanine amidase II YP_002410495.1 4835529 D 585057 CDS YP_002410496.1 218702867 7150726 4836873..4838723 1 NC_011750.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 4838723 mutL 7150726 mutL Escherichia coli IAI39 DNA mismatch repair protein YP_002410496.1 4836873 D 585057 CDS YP_002410497.1 218702868 7152156 4838716..4839666 1 NC_011750.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 4839666 miaA 7152156 miaA Escherichia coli IAI39 tRNA delta(2)-isopentenylpyrophosphate transferase YP_002410497.1 4838716 D 585057 CDS YP_002410498.1 218702869 7152078 4839753..4840061 1 NC_011750.1 Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 4840061 hfq 7152078 hfq Escherichia coli IAI39 RNA-binding protein Hfq YP_002410498.1 4839753 D 585057 CDS YP_002410499.1 218702870 7151641 4840138..4841418 1 NC_011750.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; putative GTPase HflX 4841418 hflX 7151641 hflX Escherichia coli IAI39 putative GTPase HflX YP_002410499.1 4840138 D 585057 CDS YP_002410500.1 218702871 7151640 4841504..4842763 1 NC_011750.1 with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 4842763 hflK 7151640 hflK Escherichia coli IAI39 FtsH protease regulator HflK YP_002410500.1 4841504 D 585057 CDS YP_002410501.1 218702872 7151639 4842766..4843770 1 NC_011750.1 with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 4843770 hflC 7151639 hflC Escherichia coli IAI39 FtsH protease regulator HflC YP_002410501.1 4842766 D 585057 CDS YP_002410502.1 218702873 7151637 4843852..4844049 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4844049 yjeT 7151637 yjeT Escherichia coli IAI39 hypothetical protein YP_002410502.1 4843852 D 585057 CDS YP_002410503.1 218702874 7154295 4844153..4845451 1 NC_011750.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 4845451 purA 7154295 purA Escherichia coli IAI39 adenylosuccinate synthetase YP_002410503.1 4844153 D 585057 CDS YP_002410504.1 218702875 7152523 4845656..4846081 1 NC_011750.1 negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 4846081 nsrR 7152523 nsrR Escherichia coli IAI39 transcriptional repressor NsrR YP_002410504.1 4845656 D 585057 CDS YP_002410505.1 218702876 7152260 4846120..4848561 1 NC_011750.1 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 4848561 rnr 7152260 rnr Escherichia coli IAI39 exoribonuclease R YP_002410505.1 4846120 D 585057 CDS YP_002410506.1 218702877 7152662 4848742..4849473 1 NC_011750.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 4849473 rlmB 7152662 rlmB Escherichia coli IAI39 23S rRNA (guanosine-2'-O-)-methyltransferase YP_002410506.1 4848742 D 585057 CDS YP_002410507.1 218702878 7152638 4849600..4850001 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4850001 yjfI 7152638 yjfI Escherichia coli IAI39 hypothetical protein YP_002410507.1 4849600 D 585057 CDS YP_002410508.1 218702879 7154299 4850020..4850718 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator effector protein 4850718 yjfJ 7154299 yjfJ Escherichia coli IAI39 putative transcriptional regulator effector protein YP_002410508.1 4850020 D 585057 CDS YP_002410509.1 218702880 7154300 4850768..4851427 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4851427 yjfK 7154300 yjfK Escherichia coli IAI39 hypothetical protein YP_002410509.1 4850768 D 585057 CDS YP_002410510.1 218702881 7154301 4851445..4851843 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4851843 yjfL 7154301 yjfL Escherichia coli IAI39 hypothetical protein YP_002410510.1 4851445 D 585057 CDS YP_002410511.1 218702882 7154302 4851853..4852491 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4852491 yjfM 7154302 yjfM Escherichia coli IAI39 hypothetical protein YP_002410511.1 4851853 D 585057 CDS YP_002410512.1 218702883 7154303 4852494..4853657 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative synthetase/amidase 4853657 yjfC 7154303 yjfC Escherichia coli IAI39 putative synthetase/amidase YP_002410512.1 4852494 D 585057 CDS YP_002410513.1 218702884 7154296 4853741..4855366 1 NC_011750.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 4855366 aidB 7154296 aidB Escherichia coli IAI39 isovaleryl CoA dehydrogenase YP_002410513.1 4853741 D 585057 CDS YP_002410514.1 218702885 7150708 complement(4855483..4855758) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4855758 yjfN 7150708 yjfN Escherichia coli IAI39 hypothetical protein YP_002410514.1 4855483 R 585057 CDS YP_002410515.1 218702886 7154304 complement(4855907..4856236) 1 NC_011750.1 in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility; putative biofilm stress and motility protein A 4856236 yjfO 7154304 yjfO Escherichia coli IAI39 putative biofilm stress and motility protein A YP_002410515.1 4855907 R 585057 CDS YP_002410516.1 218702887 7154305 4856418..4857167 1 NC_011750.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 4857167 yjfP 7154305 yjfP Escherichia coli IAI39 esterase YP_002410516.1 4856418 D 585057 CDS YP_002410517.1 218702888 7154306 complement(4857164..4857919) 1 NC_011750.1 negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR 4857919 ulaR 7154306 ulaR Escherichia coli IAI39 transcriptional repressor UlaR YP_002410517.1 4857164 R 585057 CDS YP_002410518.1 218702889 7153101 complement(4858027..4859091) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12644495, 15808744; Product type pe : putative enzyme; putative L-ascorbate 6-phosphate lactonase 4859091 ulaG 7153101 ulaG Escherichia coli IAI39 putative L-ascorbate 6-phosphate lactonase YP_002410518.1 4858027 R 585057 CDS YP_002410519.1 218702890 7153100 4859389..4860843 1 NC_011750.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 4860843 ulaA 7153100 ulaA Escherichia coli IAI39 PTS system ascorbate-specific transporter subunit IIC YP_002410519.1 4859389 D 585057 CDS YP_002410520.1 218702891 7153094 4860859..4861164 1 NC_011750.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIB 4861164 ulaB 7153094 ulaB Escherichia coli IAI39 PTS system L-ascorbate-specific transporter subunit IIB YP_002410520.1 4860859 D 585057 CDS YP_002410521.1 218702892 7153095 4861174..4861638 1 NC_011750.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIA 4861638 ulaC 7153095 ulaC Escherichia coli IAI39 PTS system L-ascorbate-specific transporter subunit IIA YP_002410521.1 4861174 D 585057 CDS YP_002410522.1 218702893 7153096 4861652..4862302 1 NC_011750.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 4862302 ulaD 7153096 ulaD Escherichia coli IAI39 3-keto-L-gulonate-6-phosphate decarboxylase YP_002410522.1 4861652 D 585057 CDS YP_002410523.1 218702894 7153097 4862312..4863166 1 NC_011750.1 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 4863166 ulaE 7153097 ulaE Escherichia coli IAI39 L-xylulose 5-phosphate 3-epimerase YP_002410523.1 4862312 D 585057 CDS YP_002410524.1 218702895 7153098 4863166..4863852 1 NC_011750.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4863852 sgaE 7153098 sgaE Escherichia coli IAI39 L-ribulose-5-phosphate 4-epimerase YP_002410524.1 4863166 D 585057 CDS YP_002410525.1 218702896 7153099 complement(4863981..4864256) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4864256 yjfY 7153099 yjfY Escherichia coli IAI39 hypothetical protein YP_002410525.1 4863981 R 585057 CDS YP_002410526.1 218702897 7154307 4864583..4864978 1 NC_011750.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 4864978 rpsF 7154307 rpsF Escherichia coli IAI39 30S ribosomal protein S6 YP_002410526.1 4864583 D 585057 CDS YP_002410527.1 218702898 7152718 4865304..4865531 1 NC_011750.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4865531 rpsR 7152718 rpsR Escherichia coli IAI39 30S ribosomal protein S18 YP_002410527.1 4865304 D 585057 CDS YP_002410528.1 218702899 7152730 4865573..4866022 1 NC_011750.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4866022 rplI 7152730 rplI Escherichia coli IAI39 50S ribosomal protein L9 YP_002410528.1 4865573 D 585057 CDS YP_002410529.1 218702900 7152677 complement(4866093..4866887) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4866887 yjfZ 7152677 yjfZ Escherichia coli IAI39 hypothetical protein YP_002410529.1 4866093 R 585057 CDS YP_002410530.1 218702901 7154308 complement(4867157..4868434) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Hexuronate transporter 4868434 7154308 ECIAI39_4669 Escherichia coli IAI39 putative Hexuronate transporter YP_002410530.1 4867157 R 585057 CDS YP_002410531.1 218702902 7150417 complement(4868527..4870599) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 4870599 7150417 ECIAI39_4670 Escherichia coli IAI39 putative oxidoreductase YP_002410531.1 4868527 R 585057 CDS YP_002410532.1 218702903 7150418 complement(4870596..4872137) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative CoA transferase 4872137 7150418 ECIAI39_4671 Escherichia coli IAI39 putative CoA transferase YP_002410532.1 4870596 R 585057 CDS YP_002410533.1 218702904 7150419 complement(4872147..4872923) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA hydratase 4872923 7150419 ECIAI39_4672 Escherichia coli IAI39 putative acyl-CoA hydratase YP_002410533.1 4872147 R 585057 CDS YP_002410534.1 218702905 7150420 complement(4872933..4873775) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 4873775 7150420 ECIAI39_4673 Escherichia coli IAI39 hypothetical protein YP_002410534.1 4872933 R 585057 CDS YP_002410535.1 218702906 7150421 complement(4873785..4874576) 1 NC_011750.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 4874576 7150421 ECIAI39_4674 Escherichia coli IAI39 3-ketoacyl-(acyl-carrier-protein) reductase YP_002410535.1 4873785 R 585057 CDS YP_002410536.1 218702907 7150422 4874717..4875436 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4875436 ytfA 7150422 ytfA Escherichia coli IAI39 putative transcriptional regulator YP_002410536.1 4874717 D 585057 CDS YP_002410537.1 218702908 7154569 complement(4875420..4876058) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8559074; Product type ps : putative structure; putative cell envelope opacity-associated protein 4876058 ytfB 7154569 ytfB Escherichia coli IAI39 putative cell envelope opacity-associated protein YP_002410537.1 4875420 R 585057 CDS YP_002410538.1 218702909 7154570 4876276..4876896 1 NC_011750.1 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 4876896 fklB 7154570 fklB Escherichia coli IAI39 peptidyl-prolyl cis-trans isomerase YP_002410538.1 4876276 D 585057 CDS YP_002410539.1 218702910 7151344 4877205..4878608 1 NC_011750.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 4878608 cycA 7151344 cycA Escherichia coli IAI39 D-alanine/D-serine/glycine permease YP_002410539.1 4877205 D 585057 CDS YP_002410540.1 218702911 7151041 4878742..4879899 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4879899 7151041 ECIAI39_4679 Escherichia coli IAI39 hypothetical protein YP_002410540.1 4878742 D 585057 CDS YP_002410541.1 218702912 7150423 4879932..4881425 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4881425 7150423 ECIAI39_4680 Escherichia coli IAI39 hypothetical protein YP_002410541.1 4879932 D 585057 CDS YP_002410542.1 218702913 7150424 complement(4881470..4882132) 1 NC_011750.1 Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein 4882132 ytfE 7150424 ytfE Escherichia coli IAI39 iron-sulfur cluster repair di-iron protein YP_002410542.1 4881470 R 585057 CDS YP_002410543.1 218702914 7154571 complement(4882240..4883214) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4883214 ytfF 7154571 ytfF Escherichia coli IAI39 hypothetical protein YP_002410543.1 4882240 R 585057 CDS YP_002410544.1 218702915 7154572 complement(4883313..4884173) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14747727; Product type e : enzyme; NAD(P)H:quinone oxidoreductase 4884173 ytfG 7154572 ytfG Escherichia coli IAI39 NAD(P)H:quinone oxidoreductase YP_002410544.1 4883313 R 585057 CDS YP_002410545.1 218702916 7154573 4884262..4884642 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20088838; Product type pr : putative regulator; putative transcriptional regulator 4884642 ytfH 7154573 ytfH Escherichia coli IAI39 putative transcriptional regulator YP_002410545.1 4884262 D 585057 CDS YP_002410546.1 218702917 7154574 complement(4884771..4886714) 1 NC_011750.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein 4886714 cpdB 7154574 cpdB Escherichia coli IAI39 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein YP_002410546.1 4884771 R 585057 CDS YP_002410547.1 218702918 7150985 4886904..4887644 1 NC_011750.1 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 4887644 cysQ 7150985 cysQ Escherichia coli IAI39 adenosine-3'(2'),5'-bisphosphate nucleotidase YP_002410547.1 4886904 D 585057 CDS YP_002410548.1 218702919 7151068 complement(4887634..4888191) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pr : putative regulator; putative transcriptional regulator 4888191 ytfJ 7151068 ytfJ Escherichia coli IAI39 putative transcriptional regulator YP_002410548.1 4887634 R 585057 CDS YP_002410549.1 218702920 7154575 4888516..4888722 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4888722 ytfK 7154575 ytfK Escherichia coli IAI39 hypothetical protein YP_002410549.1 4888516 D 585057 CDS YP_002410550.1 218702921 7154576 complement(4888783..4890126) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4890126 ytfL 7154576 ytfL Escherichia coli IAI39 hypothetical protein YP_002410550.1 4888783 R 585057 CDS YP_002410551.1 218702922 7154577 complement(4890449..4891087) 1 NC_011750.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 4891087 msrA 7154577 msrA Escherichia coli IAI39 methionine sulfoxide reductase A YP_002410551.1 4890449 R 585057 CDS YP_002410552.1 218702923 7152134 4891293..4893026 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4893026 ytfM 7152134 ytfM Escherichia coli IAI39 hypothetical protein YP_002410552.1 4891293 D 585057 CDS YP_002410553.1 218702924 7154578 4893023..4896802 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4896802 ytfN 7154578 ytfN Escherichia coli IAI39 hypothetical protein YP_002410553.1 4893023 D 585057 CDS YP_002410554.1 218702925 7154579 4896805..4897146 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4897146 ytfP 7154579 ytfP Escherichia coli IAI39 hypothetical protein YP_002410554.1 4896805 D 585057 CDS YP_002410555.1 218702926 7154580 4897358..4897609 1 NC_011750.1 part of the toxin-antitoxin ChpB-ChpS system; antitoxin ChpS 4897609 chpS 7154580 chpS Escherichia coli IAI39 antitoxin ChpS YP_002410555.1 4897358 D 585057 CDS YP_002410556.1 218702927 7150943 4897603..4897953 1 NC_011750.1 toxin of the ChpB-ChpS toxin-antitoxin system; toxin ChpB 4897953 chpB 7150943 chpB Escherichia coli IAI39 toxin ChpB YP_002410556.1 4897603 D 585057 CDS YP_002410557.1 218702928 7150941 complement(4898032..4898562) 1 NC_011750.1 catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 4898562 ppa 7150941 ppa Escherichia coli IAI39 inorganic pyrophosphatase YP_002410557.1 4898032 R 585057 CDS YP_002410558.1 218702929 7152452 4898872..4899828 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pt : putative transporter; putative sugar ABC transporter periplasmic-binding protein 4899828 ytfQ 7152452 ytfQ Escherichia coli IAI39 putative sugar ABC transporter periplasmic-binding protein YP_002410558.1 4898872 D 585057 CDS YP_002410559.1 218702930 7154581 4899968..4901470 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter ATP-binding protein 4901470 ytfR 7154581 ytfR Escherichia coli IAI39 putative sugar ABC transporter ATP-binding protein YP_002410559.1 4899968 D 585057 CDS YP_002410560.1 218702931 7154582 4901484..4902506 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter membrane protein 4902506 ytfT 7154582 ytfT Escherichia coli IAI39 putative sugar ABC transporter membrane protein YP_002410560.1 4901484 D 585057 CDS YP_002410561.1 218702932 7154297 4902928..4904274 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase, IS4 4904274 insG 7154297 insG Escherichia coli IAI39 transposase, IS4 YP_002410561.1 4902928 D 585057 CDS YP_002410562.1 218702933 7154298 complement(4904960..4905958) 1 NC_011750.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 4905958 fbp 7154298 fbp Escherichia coli IAI39 fructose-1,6-bisphosphatase YP_002410562.1 4904960 R 585057 CDS YP_002410563.1 218702934 7151281 4906134..4907507 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96404780, 2843822, 7984428, 8808921; Product type e : enzyme; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 4907507 mpl 7151281 mpl Escherichia coli IAI39 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase YP_002410563.1 4906134 D 585057 CDS YP_002410564.1 218702935 7152114 complement(4907588..4908310) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 4908310 7152114 ECIAI39_4706 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002410564.1 4907588 R 585057 CDS YP_002410565.1 218702936 7150425 complement(4908415..4908945) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 4908945 7150425 ECIAI39_4707 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002410565.1 4908415 R 585057 CDS YP_002410566.1 218702937 7150426 complement(4909099..4909650) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4909650 yjgA 7150426 yjgA Escherichia coli IAI39 hypothetical protein YP_002410566.1 4909099 R 585057 CDS YP_002410567.1 218702938 7154309 4909744..4911096 1 NC_011750.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 4911096 pmbA 7154309 pmbA Escherichia coli IAI39 peptidase PmbA YP_002410567.1 4909744 D 585057 CDS YP_002410568.1 218702939 7152431 4911280..4911666 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1761034, 8499452, 10393541; Product type c : carrier; soluble cytochrome b562 4911666 cybC 7152431 cybC Escherichia coli IAI39 soluble cytochrome b562 YP_002410568.1 4911280 D 585057 CDS YP_002410569.1 218702940 7151040 4911857..4912096 1 NC_011750.1 Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor; bifunctional antitoxin/transcriptional repressor RelB 4912096 7151040 ECIAI39_4711 Escherichia coli IAI39 bifunctional antitoxin/transcriptional repressor RelB YP_002410569.1 4911857 D 585057 CDS YP_002410570.1 218702941 7150427 complement(4912097..4912561) 1 NC_011750.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein 4912561 nrdG 7150427 nrdG Escherichia coli IAI39 anaerobic ribonucleotide reductase-activating protein YP_002410570.1 4912097 R 585057 CDS YP_002410571.1 218702942 7152249 complement(4912751..4914889) 1 NC_011750.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 4914889 nrdD 7152249 nrdD Escherichia coli IAI39 anaerobic ribonucleoside triphosphate reductase YP_002410571.1 4912751 R 585057 CDS YP_002410572.1 218702943 7152246 complement(4915283..4916938) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264345, 93302496, 8083158, 8421692; Product type e : enzyme; trehalose-6-phosphate hydrolase 4916938 treC 7152246 treC Escherichia coli IAI39 trehalose-6-phosphate hydrolase YP_002410572.1 4915283 R 585057 CDS YP_002410573.1 218702944 7153019 complement(4916988..4918409) 1 NC_011750.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system trehalose(maltose)-specific transporter subunits IIBC 4918409 treB 7153019 treB Escherichia coli IAI39 PTS system trehalose(maltose)-specific transporter subunits IIBC YP_002410573.1 4916988 R 585057 CDS YP_002410574.1 218702945 7153018 complement(4918528..4919475) 1 NC_011750.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor 4919475 treR 7153018 treR Escherichia coli IAI39 trehalose repressor YP_002410574.1 4918528 R 585057 CDS YP_002410575.1 218702946 7153021 4919854..4922550 1 NC_011750.1 P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 4922550 mgtA 7153021 mgtA Escherichia coli IAI39 magnesium-transporting ATPase MgtA YP_002410575.1 4919854 D 585057 CDS YP_002410576.1 218702947 7152069 complement(4922756..4923142) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12515541, 10493123, 10595546, 9298646; Product type pe : putative enzyme; ketoacid-binding protein 4923142 yjgF 7152069 yjgF Escherichia coli IAI39 ketoacid-binding protein YP_002410576.1 4922756 R 585057 CDS YP_002410577.1 218702948 7154312 complement(4923215..4923676) 1 NC_011750.1 involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase regulatory subunit 4923676 pyrI 7154312 pyrI Escherichia coli IAI39 aspartate carbamoyltransferase regulatory subunit YP_002410577.1 4923215 R 585057 CDS YP_002410578.1 218702949 7152555 complement(4923689..4924624) 1 NC_011750.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 4924624 pyrB 7152555 pyrB Escherichia coli IAI39 aspartate carbamoyltransferase catalytic subunit YP_002410578.1 4923689 R 585057 CDS YP_002410579.1 218702950 7152548 complement(4924628..4924762) 1 NC_011750.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; pyrBI operon leader peptide 4924762 pyrL 7152548 pyrL Escherichia coli IAI39 pyrBI operon leader peptide YP_002410579.1 4924628 R 585057 CDS YP_002410580.1 218702951 7152556 complement(4924852..4925406) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative arginine repressor 4925406 7152556 ECIAI39_4721 Escherichia coli IAI39 putative arginine repressor YP_002410580.1 4924852 R 585057 CDS YP_002410581.1 218702952 7150428 complement(4925456..4926904) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative C4-dicarboxylate transport membrane protein 4926904 7150428 ECIAI39_4722 Escherichia coli IAI39 putative C4-dicarboxylate transport membrane protein YP_002410581.1 4925456 R 585057 CDS YP_002410582.1 218702953 7150429 complement(4926916..4927947) 1 NC_011750.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 4927947 arcB 7150429 arcB Escherichia coli IAI39 ornithine carbamoyltransferase YP_002410582.1 4926916 R 585057 CDS YP_002410583.1 218702954 7150758 complement(4927944..4928900) 1 NC_011750.1 reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 4928900 arcC 7150758 arcC Escherichia coli IAI39 carbamate kinase YP_002410583.1 4927944 R 585057 CDS YP_002410584.1 218702955 7150759 complement(4928887..4930110) 1 NC_011750.1 catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 4930110 7150759 ECIAI39_4725 Escherichia coli IAI39 arginine deiminase YP_002410584.1 4928887 R 585057 CDS YP_002410585.1 218702956 7150430 4930785..4931237 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11115104; hypothetical protein 4931237 yjgK 7150430 yjgK Escherichia coli IAI39 hypothetical protein YP_002410585.1 4930785 D 585057 CDS YP_002410586.1 218702957 7154313 complement(4931282..4932286) 1 NC_011750.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase; when both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III; ornithine carbamoyltransferase subunit F 4932286 argI 7154313 argI Escherichia coli IAI39 ornithine carbamoyltransferase subunit F YP_002410586.1 4931282 R 585057 CDS YP_002410587.1 218702958 7150767 4932448..4932864 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4932864 yjgD 7150767 yjgD Escherichia coli IAI39 hypothetical protein YP_002410587.1 4932448 D 585057 CDS YP_002410588.1 218702959 7154311 complement(4933041..4933544) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase 4933544 yjgM 7154311 yjgM Escherichia coli IAI39 putative acetyltransferase YP_002410588.1 4933041 R 585057 CDS YP_002410589.1 218702960 7154314 4933737..4934924 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type m : membrane component; hypothetical protein 4934924 yjgN 7154314 yjgN Escherichia coli IAI39 hypothetical protein YP_002410589.1 4933737 D 585057 CDS YP_002410590.1 218702961 7154315 complement(4934971..4937826) 1 NC_011750.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 4937826 valS 7154315 valS Escherichia coli IAI39 valyl-tRNA synthetase YP_002410590.1 4934971 R 585057 CDS YP_002410591.1 218702962 7153126 complement(4937826..4938269) 1 NC_011750.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 4938269 holC 7153126 holC Escherichia coli IAI39 DNA polymerase III subunit chi YP_002410591.1 4937826 R 585057 CDS YP_002410592.1 218702963 7151669 complement(4938623..4940134) 1 NC_011750.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 4940134 pepA 7151669 pepA Escherichia coli IAI39 leucyl aminopeptidase YP_002410592.1 4938623 R 585057 CDS YP_002410593.1 218702964 7152361 4940401..4941501 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4941501 yjgP 7152361 yjgP Escherichia coli IAI39 hypothetical protein YP_002410593.1 4940401 D 585057 CDS YP_002410594.1 218702965 7154316 4941501..4942583 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4942583 yjgQ 7154316 yjgQ Escherichia coli IAI39 hypothetical protein YP_002410594.1 4941501 D 585057 CDS YP_002410595.1 218702966 7154317 complement(4942702..4944204) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATPase 4944204 yjgR 7154317 yjgR Escherichia coli IAI39 putative ATPase YP_002410595.1 4942702 R 585057 CDS YP_002410596.1 218702967 7154318 complement(4944282..4945280) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9119199, 98324983, 9658018; Product type r : regulator; DNA-binding transcriptional repressor, 5-gluconate-binding 4945280 idnR 7154318 idnR Escherichia coli IAI39 DNA-binding transcriptional repressor, 5-gluconate-binding YP_002410596.1 4944282 R 585057 CDS YP_002410597.1 218702968 7151757 complement(4945347..4946666) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 9119199, 93139975, 98324983, 9658018; Product type t : transporter; L-idonate and D-gluconate transporter 4946666 idnT 7151757 idnT Escherichia coli IAI39 L-idonate and D-gluconate transporter YP_002410597.1 4945347 R 585057 CDS YP_002410598.1 218702969 7151758 complement(4946731..4947495) 1 NC_011750.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase 4947495 idnO 7151758 idnO Escherichia coli IAI39 gluconate 5-dehydrogenase YP_002410598.1 4946731 R 585057 CDS YP_002410599.1 218702970 7151756 complement(4947519..4948550) 1 NC_011750.1 NAD-binding; L-idonate 5-dehydrogenase 4948550 idnD 7151756 idnD Escherichia coli IAI39 L-idonate 5-dehydrogenase YP_002410599.1 4947519 R 585057 CDS YP_002410600.1 218702971 7151754 4948767..4949330 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87310381, 93139975, 98324983, 9658018, 14832279; Product type e : enzyme; D-gluconate kinase 4949330 idnK 7151754 idnK Escherichia coli IAI39 D-gluconate kinase YP_002410600.1 4948767 D 585057 CDS YP_002410601.1 218702972 7151755 complement(4949334..4950353) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12147722; Product type pe : putative enzyme; putative alcohol dehydrogenase, Zn-dependent and NAD(P)-binding 4950353 yjgB 7151755 yjgB Escherichia coli IAI39 putative alcohol dehydrogenase, Zn-dependent and NAD(P)-binding YP_002410601.1 4949334 R 585057 CDS YP_002410602.1 218702973 7150583 4950895..4952085 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative integrase; KpLE2 phage-like element 4952085 intB 7150583 intB Escherichia coli IAI39 putative integrase; KpLE2 phage-like element YP_002410602.1 4950895 D 585057 CDS YP_002410604.1 218702975 7150432 4954084..4954227 1 NC_011750.1 Evidence 6 : Doubtful CDS; hypothetical protein 4954227 7150432 ECIAI39_4746 Escherichia coli IAI39 hypothetical protein YP_002410604.1 4954084 D 585057 CDS YP_002410605.1 218702976 7150433 4954772..4955989 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sialic acid transporter 4955989 yjhB 7150433 yjhB Escherichia coli IAI39 putative sialic acid transporter YP_002410605.1 4954772 D 585057 CDS YP_002410606.1 218702977 7154320 4956001..4957119 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 4957119 yjhC 7154320 yjhC Escherichia coli IAI39 putative oxidoreductase YP_002410606.1 4956001 D 585057 CDS YP_002410607.1 218702978 7154321 complement(4957340..4957570) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4957570 yjhD 7154321 yjhD Escherichia coli IAI39 hypothetical protein YP_002410607.1 4957340 R 585057 CDS YP_002410608.1 218702979 7154322 4957575..4957823 1 NC_011750.1 hypothetical protein 4957823 7154322 ECIAI39_4750 Escherichia coli IAI39 hypothetical protein YP_002410608.1 4957575 D 585057 CDS YP_002410609.1 218702980 7150434 4957911..4958087 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF A (fragment), IS911 4958087 7150434 ECIAI39_4751 Escherichia coli IAI39 transposase ORF A (fragment), IS911 YP_002410609.1 4957911 D 585057 CDS YP_002410610.1 218702981 7150435 4958373..4959134 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase (fragment), IS110 family 4959134 7150435 ECIAI39_4752 Escherichia coli IAI39 transposase (fragment), IS110 family YP_002410610.1 4958373 D 585057 CDS YP_002410611.1 218702982 7150436 complement(4959261..4960151) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 4960151 7150436 ECIAI39_4753 Escherichia coli IAI39 transposase ORF B, IS629 YP_002410611.1 4959261 R 585057 CDS YP_002410612.1 218702983 7150437 complement(4960148..4960474) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 4960474 7150437 ECIAI39_4754 Escherichia coli IAI39 transposase ORF A, IS629 YP_002410612.1 4960148 R 585057 CDS YP_002410613.1 218702984 7150438 complement(4960500..4961786) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702297; Product type t : transporter; betaine-carnitine-choline transporter family member 4961786 betU 7150438 betU Escherichia coli IAI39 betaine-carnitine-choline transporter family member YP_002410613.1 4960500 R 585057 CDS YP_002410614.1 218702985 7150856 complement(4961934..4962752) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 4962752 7150856 ECIAI39_4756 Escherichia coli IAI39 transposase ORF B, IS600 YP_002410614.1 4961934 R 585057 CDS YP_002410615.1 218702986 7151826 complement(4963268..4964212) 1 NC_011750.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 4964212 msbB 7151826 msbB Escherichia coli IAI39 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_002410615.1 4963268 R 585057 CDS YP_002410616.1 218702987 7152131 complement(4964277..4965227) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1406277; Product type r : regulator; regulator of virG protein 4965227 virK 7152131 virK Escherichia coli IAI39 regulator of virG protein YP_002410616.1 4964277 R 585057 CDS YP_002410617.1 218702988 7153129 complement(4965232..4966320) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Glycosyl transferase 4966320 7153129 ECIAI39_4760 Escherichia coli IAI39 Glycosyl transferase YP_002410617.1 4965232 R 585057 CDS YP_002410618.1 218702989 7150440 complement(4966323..4967144) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative polysaccharide deacetylase 4967144 shf 7150440 shf Escherichia coli IAI39 putative polysaccharide deacetylase YP_002410618.1 4966323 R 585057 CDS YP_002410619.1 218702990 7152849 4967309..4967653 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS911 4967653 7152849 ECIAI39_4762 Escherichia coli IAI39 transposase ORF A, IS911 YP_002410619.1 4967309 D 585057 CDS YP_002410620.1 218702991 7150441 4967709..4968308 1 NC_011750.1 Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS911 4968308 insO 7150441 insO Escherichia coli IAI39 transposase ORF B (fragment), IS911 YP_002410620.1 4967709 D 585057 CDS YP_002410621.1 218702992 7151827 4968474..4968887 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4968887 yjhV 7151827 yjhV Escherichia coli IAI39 hypothetical protein YP_002410621.1 4968474 D 585057 CDS YP_002410622.1 218702993 7154325 complement(4969445..4970212) 1 NC_011750.1 Part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate transporter ATP-binding subunit 4970212 fecE 7154325 fecE Escherichia coli IAI39 iron-dicitrate transporter ATP-binding subunit YP_002410622.1 4969445 R 585057 CDS YP_002410623.1 218702994 7151298 complement(4970213..4971199) 1 NC_011750.1 Ferric citrate binds FecA and is transported across the outer membrane while transmits a signal across the cytoplasmic membrane protein FecR. FecR transmits a signal across the membrane and activates the cytoplasmic FecI that directs the RNA polymerase to express the fecABCDE operon (which encodes the ferric citrate outer membrane receptor and the ferric citrate ABC transporter), as well as fecIR. FecD is one of two (along with FecC) integral membrane protein components of the iron dicitrate ABC transporter.; iron-dicitrate transporter subunit FecD 4971199 fecD 7151298 fecD Escherichia coli IAI39 iron-dicitrate transporter subunit FecD YP_002410623.1 4970213 R 585057 CDS YP_002410624.1 218702995 7151297 complement(4971166..4972164) 1 NC_011750.1 part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate transporter permease subunit 4972164 fecC 7151297 fecC Escherichia coli IAI39 iron-dicitrate transporter permease subunit YP_002410624.1 4971166 R 585057 CDS YP_002410625.1 218702996 7151296 complement(4972161..4973063) 1 NC_011750.1 part of the ABC transporter involved in the uptake of citrate-dependent Fe(3+); iron-dicitrate transporter substrate-binding subunit 4973063 fecB 7151296 fecB Escherichia coli IAI39 iron-dicitrate transporter substrate-binding subunit YP_002410625.1 4972161 R 585057 CDS YP_002410626.1 218702997 7151295 complement(4973108..4975432) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90105402, 91072220, 92269759, 2836368; Product type t : transporter; ferric citrate outer membrane transporter; KpLE2 phage-like element 4975432 fecA 7151295 fecA Escherichia coli IAI39 ferric citrate outer membrane transporter; KpLE2 phage-like element YP_002410626.1 4973108 R 585057 CDS YP_002410627.1 218702998 7151294 complement(4975519..4976472) 1 NC_011750.1 with FecA forms the FecAR signal transduction system; ferric citrate binds FecA and transmits a signal across the outer membrane to FecR. FecR transmits a signal across the cytoplasmic membrane and activates the sigma 70 protein FecI that directs the RNA polymerase to express the fecABCDE operon; fec operon regulator FecR 4976472 fecR 7151294 fecR Escherichia coli IAI39 fec operon regulator FecR YP_002410627.1 4975519 R 585057 CDS YP_002410628.1 218702999 7151300 complement(4976469..4976990) 1 NC_011750.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor regulates the genes for iron dicitrate transport; RNA polymerase sigma factor FecI 4976990 fecI 7151300 fecI Escherichia coli IAI39 RNA polymerase sigma factor FecI YP_002410628.1 4976469 R 585057 CDS YP_002410629.1 218703000 7151299 4977282..4977557 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1849492; Product type r : regulator; IS1 repressor protein InsA; KpLE2 phage-like element 4977557 insA 7151299 insA Escherichia coli IAI39 IS1 repressor protein InsA; KpLE2 phage-like element YP_002410629.1 4977282 D 585057 CDS YP_002410630.1 218703001 7151790 4977476..4977979 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 4977979 insB 7151790 insB Escherichia coli IAI39 IS1 transposase InsAB' YP_002410630.1 4977476 D 585057 CDS YP_002410631.1 218703002 7151801 complement(4978466..4979356) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 4979356 7151801 ECIAI39_4774 Escherichia coli IAI39 transposase ORF B, IS629 YP_002410631.1 4978466 R 585057 CDS YP_002410632.1 218703003 7150442 complement(4979353..4979679) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 4979679 7150442 ECIAI39_4775 Escherichia coli IAI39 transposase ORF A, IS629 YP_002410632.1 4979353 R 585057 CDS YP_002410633.1 218703004 7150443 complement(4979731..4980747) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative restriction system component 4980747 7150443 ECIAI39_4776 Escherichia coli IAI39 putative restriction system component YP_002410633.1 4979731 R 585057 CDS YP_002410634.1 218703005 7150446 complement(4982985..4983914) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4983914 7150446 ECIAI39_4779 Escherichia coli IAI39 hypothetical protein YP_002410634.1 4982985 R 585057 CDS YP_002410635.1 218703006 7150447 complement(4984069..4985049) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4985049 yjhS 7150447 yjhS Escherichia coli IAI39 hypothetical protein YP_002410635.1 4984069 R 585057 CDS YP_002410636.1 218703007 7154323 complement(4985114..4986220) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; N-acetylneuraminic acid mutarotase 4986220 yjhT 7154323 yjhT Escherichia coli IAI39 N-acetylneuraminic acid mutarotase YP_002410636.1 4985114 R 585057 CDS YP_002410637.1 218703008 7154324 complement(4986240..4986956) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15743943; Product type t : transporter; N-acetylnuraminic acid outer membrane channel protein 4986956 yjhA 7154324 yjhA Escherichia coli IAI39 N-acetylnuraminic acid outer membrane channel protein YP_002410637.1 4986240 R 585057 CDS YP_002410638.1 218703009 7154319 complement(4987833..4988150) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4988150 7154319 ECIAI39_4783 Escherichia coli IAI39 hypothetical protein YP_002410638.1 4987833 R 585057 CDS YP_002410639.1 218703010 7150448 4988411..4989013 1 NC_011750.1 inversion of on/off regulator of fimA; tyrosine recombinase 4989013 fimB 7150448 fimB Escherichia coli IAI39 tyrosine recombinase YP_002410639.1 4988411 D 585057 CDS YP_002410640.1 218703011 7151329 4989491..4990087 1 NC_011750.1 inversion of on/off regulator of fimA; tyrosine recombinase 4990087 fimE 7151329 fimE Escherichia coli IAI39 tyrosine recombinase YP_002410640.1 4989491 D 585057 CDS YP_002410641.1 218703012 7151332 complement(4990166..4990381) 1 NC_011750.1 hypothetical protein 4990381 7151332 ECIAI39_4786 Escherichia coli IAI39 hypothetical protein YP_002410641.1 4990166 R 585057 CDS YP_002410642.1 218703013 7150449 4990568..4991116 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6146599, 6147250, 90220509, 93106965, 2858471, 6123483; Product type s : structure; major type 1 subunit fimbrin 4991116 fimA 7150449 fimA Escherichia coli IAI39 major type 1 subunit fimbrin YP_002410642.1 4990568 D 585057 CDS YP_002410643.1 218703014 7151328 4991181..4991720 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12897022, 11673421, 6147250; Product type s : structure; type 1 pilus biosynthesis fimbrial protein 4991720 fimI 7151328 fimI Escherichia coli IAI39 type 1 pilus biosynthesis fimbrial protein YP_002410643.1 4991181 D 585057 CDS YP_002410644.1 218703015 7151336 4991757..4992482 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20450729, 90220509, 93155127, 93391362, 1363735, 8104335, 8636962, 9783748; Product type f : factor; chaperone, periplasmic 4992482 fimC 7151336 fimC Escherichia coli IAI39 chaperone, periplasmic YP_002410644.1 4991757 D 585057 CDS YP_002410645.1 218703016 7151330 4992549..4995185 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12842468, 90220509, 1970114; Product type f : factor; outer membrane usher protein, type 1 fimbrial synthesis 4995185 fimD 7151330 fimD Escherichia coli IAI39 outer membrane usher protein, type 1 fimbrial synthesis YP_002410645.1 4992549 D 585057 CDS YP_002410646.1 218703017 7151331 4995195..4995725 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 92394896, 1970114, 2890081; Product type s : structure; minor component of type 1 fimbriae 4995725 fimF 7151331 fimF Escherichia coli IAI39 minor component of type 1 fimbriae YP_002410646.1 4995195 D 585057 CDS YP_002410647.1 218703018 7151333 4995738..4996241 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 92394896, 2890081; Product type s : structure; minor component of type 1 fimbriae 4996241 fimG 7151333 fimG Escherichia coli IAI39 minor component of type 1 fimbriae YP_002410647.1 4995738 D 585057 CDS YP_002410648.1 218703019 7151334 4996261..4997163 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 93155127, 93391362, 1971261, 2890081, 2900235; Product type s : structure; minor component of type 1 fimbriae 4997163 fimH 7151334 fimH Escherichia coli IAI39 minor component of type 1 fimbriae YP_002410648.1 4996261 D 585057 CDS YP_002410649.1 218703020 7151335 complement(4997413..4998756) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96125229, 15516583, 8550444; Product type t : transporter; fructuronate transporter 4998756 gntP 7151335 gntP Escherichia coli IAI39 fructuronate transporter YP_002410649.1 4997413 R 585057 CDS YP_002410650.1 218703021 7151570 4999096..5000280 1 NC_011750.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 5000280 uxuA 7151570 uxuA Escherichia coli IAI39 mannonate dehydratase YP_002410650.1 4999096 D 585057 CDS YP_002410651.1 218703022 7153121 5000361..5001821 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73203083, 77222076, 14401695; Product type e : enzyme; D-mannonate oxidoreductase, NAD-binding 5001821 uxuB 7153121 uxuB Escherichia coli IAI39 D-mannonate oxidoreductase, NAD-binding YP_002410651.1 5000361 D 585057 CDS YP_002410652.1 218703023 7153122 5002036..5002809 1 NC_011750.1 regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 5002809 uxuR 7153122 uxuR Escherichia coli IAI39 DNA-binding transcriptional repressor UxuR YP_002410652.1 5002036 D 585057 CDS YP_002410653.1 218703024 7153123 complement(5002950..5003780) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5003780 yjiC 7153123 yjiC Escherichia coli IAI39 hypothetical protein YP_002410653.1 5002950 R 585057 CDS YP_002410654.1 218703025 7154327 complement(5003698..5003871) 1 NC_011750.1 hypothetical protein 5003871 7154327 ECIAI39_4799 Escherichia coli IAI39 hypothetical protein YP_002410654.1 5003698 R 585057 CDS YP_002410655.1 218703026 7150450 5004453..5004845 1 NC_011750.1 inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS; DNA replication/recombination/repair protein 5004845 iraD 7150450 iraD Escherichia coli IAI39 DNA replication/recombination/repair protein YP_002410655.1 5004453 D 585057 CDS YP_002410656.1 218703027 7154328 complement(5004838..5005749) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 5005749 yjiE 7154328 yjiE Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002410656.1 5004838 R 585057 CDS YP_002410657.1 218703028 7154329 complement(5005814..5006986) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95181377, 7876157; Product type e : enzyme; isoaspartyl dipeptidase 5006986 iadA 7154329 iadA Escherichia coli IAI39 isoaspartyl dipeptidase YP_002410657.1 5005814 R 585057 CDS YP_002410658.1 218703029 7151742 complement(5006999..5007460) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5007460 yjiG 7151742 yjiG Escherichia coli IAI39 hypothetical protein YP_002410658.1 5006999 R 585057 CDS YP_002410659.1 218703030 7154330 complement(5007457..5008140) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5008140 yjiH 7154330 yjiH Escherichia coli IAI39 hypothetical protein YP_002410659.1 5007457 R 585057 CDS YP_002410660.1 218703031 7154333 complement(5010202..5011170) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5011170 yjiK 7154333 yjiK Escherichia coli IAI39 hypothetical protein YP_002410660.1 5010202 R 585057 CDS YP_002410661.1 218703032 7154334 complement(5011127..5011384) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5011384 7154334 ECIAI39_4810 Escherichia coli IAI39 hypothetical protein YP_002410661.1 5011127 R 585057 CDS YP_002410662.1 218703033 7150451 complement(5011381..5012148) 1 NC_011750.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8365476, 7607244, 15654892; Product type e : enzyme; ATPase, activator of (R)-hydroxyglutaryl-CoA dehydratase 5012148 hgdC 7150451 hgdC Escherichia coli IAI39 ATPase, activator of (R)-hydroxyglutaryl-CoA dehydratase YP_002410662.1 5011381 R 585057 CDS YP_002410663.1 218703034 7151642 complement(5012158..5013309) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3691501, 11106419; Product type pe : putative enzyme; putative 2-hydroxyglutaryl-CoA dehydratase 5013309 yjiM 7151642 yjiM Escherichia coli IAI39 putative 2-hydroxyglutaryl-CoA dehydratase YP_002410663.1 5012158 R 585057 CDS YP_002410664.1 218703035 7154335 complement(5013425..5014705) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5014705 yjiN 7154335 yjiN Escherichia coli IAI39 hypothetical protein YP_002410664.1 5013425 R 585057 CDS YP_002410665.1 218703036 7154336 5014890..5015810 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase 5015810 7154336 ECIAI39_4814 Escherichia coli IAI39 putative transposase YP_002410665.1 5014890 D 585057 CDS YP_002410666.1 218703037 7150452 5016090..5018312 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5018312 7150452 ECIAI39_4815 Escherichia coli IAI39 hypothetical protein YP_002410666.1 5016090 D 585057 CDS YP_002410667.1 218703038 7150453 complement(5018359..5018700) 1 NC_011750.1 involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response; endoribonuclease SymE 5018700 yjiW 7150453 yjiW Escherichia coli IAI39 endoribonuclease SymE YP_002410667.1 5018359 R 585057 CDS YP_002410668.1 218703039 7152795 complement(5018921..5020681) 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Type I restriction enzyme EcoAI specificity protein (S protein) (S.EcoAI) 5020681 hsdS 7152795 hsdS Escherichia coli IAI39 Type I restriction enzyme EcoAI specificity protein (S protein) (S.EcoAI) YP_002410668.1 5018921 R 585057 CDS YP_002410669.1 218703040 7151679 complement(5020681..5022186) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8412658, 1409708; Product type e : enzyme; Type I restriction enzyme EcoEI M protein (M.EcoEI) 5022186 hsdM 7151679 hsdM Escherichia coli IAI39 Type I restriction enzyme EcoEI M protein (M.EcoEI) YP_002410669.1 5020681 R 585057 CDS YP_002410670.1 218703041 7151677 complement(5022217..5024649) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9837717, 10373579, 10733903, 8412658; Product type e : enzyme; Type I restriction enzyme EcoAI R protein (R.EcoAI) 5024649 hsdR 7151677 hsdR Escherichia coli IAI39 Type I restriction enzyme EcoAI R protein (R.EcoAI) YP_002410670.1 5022217 R 585057 CDS YP_002410671.1 218703042 7151678 5024906..5025373 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5025373 7151678 ECIAI39_4820 Escherichia coli IAI39 hypothetical protein YP_002410671.1 5024906 D 585057 CDS YP_002410672.1 218703043 7150454 5025409..5026578 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5026578 7150454 ECIAI39_4821 Escherichia coli IAI39 hypothetical protein YP_002410672.1 5025409 D 585057 CDS YP_002410673.1 218703044 7150455 complement(5026647..5027603) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14696199; Product type pe : putative enzyme; putative GTP-binding protein YjiA 5027603 yjiA 7150455 yjiA Escherichia coli IAI39 putative GTP-binding protein YjiA YP_002410673.1 5026647 R 585057 CDS YP_002410674.1 218703045 7154326 complement(5027614..5027817) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5027817 yjiX 7154326 yjiX Escherichia coli IAI39 hypothetical protein YP_002410674.1 5027614 R 585057 CDS YP_002410675.1 218703046 7154338 complement(5027867..5030017) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5030017 yjiY 7154338 yjiY Escherichia coli IAI39 hypothetical protein YP_002410675.1 5027867 R 585057 CDS YP_002410676.1 218703047 7154339 5030395..5032059 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20015410, 89034150, 91317710, 10466731, 2033064, 6213619, 6402709, 8384293; Product type r : regulator; methyl-accepting chemotaxis protein I, serine sensor receptor 5032059 tsr 7154339 tsr Escherichia coli IAI39 methyl-accepting chemotaxis protein I, serine sensor receptor YP_002410676.1 5030395 D 585057 CDS YP_002410677.1 218703048 7153048 complement(5032102..5033373) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative C4-dicarboxylate transporter large permease 5033373 7153048 ECIAI39_4826 Escherichia coli IAI39 putative C4-dicarboxylate transporter large permease YP_002410677.1 5032102 R 585057 CDS YP_002410678.1 218703049 7150456 complement(5033481..5033843) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative tripartite ATP-independent periplasmic transporter (dctQ-like) 5033843 7150456 ECIAI39_4827 Escherichia coli IAI39 putative tripartite ATP-independent periplasmic transporter (dctQ-like) YP_002410678.1 5033481 R 585057 CDS YP_002410679.1 218703050 7150457 complement(5033907..5034878) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative C4-dicarboxylate-binding periplasmic protein 5034878 7150457 ECIAI39_4828 Escherichia coli IAI39 putative C4-dicarboxylate-binding periplasmic protein YP_002410679.1 5033907 R 585057 CDS YP_002410680.1 218703051 7150458 5035548..5037221 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Na(+)/H(+) exchanger 5037221 7150458 ECIAI39_4829 Escherichia coli IAI39 putative Na(+)/H(+) exchanger YP_002410680.1 5035548 D 585057 CDS YP_002410681.1 218703052 7150459 complement(5037392..5038297) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 5038297 yjjM 7150459 yjjM Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002410681.1 5037392 R 585057 CDS YP_002410682.1 218703053 7154346 complement(5039598..5041889) 1 NC_011750.1 catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I 5041889 mdoB 7154346 mdoB Escherichia coli IAI39 phosphoglycerol transferase I YP_002410682.1 5039598 R 585057 CDS YP_002410683.1 218703054 7152024 complement(5042143..5042637) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5042637 yjjA 7152024 yjjA Escherichia coli IAI39 hypothetical protein YP_002410683.1 5042143 R 585057 CDS YP_002410684.1 218703055 7154340 complement(5042686..5043423) 1 NC_011750.1 acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC 5043423 dnaC 7154340 dnaC Escherichia coli IAI39 DNA replication protein DnaC YP_002410684.1 5042686 R 585057 CDS YP_002410685.1 218703056 7151155 complement(5043426..5043965) 1 NC_011750.1 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI 5043965 dnaT 7151155 dnaT Escherichia coli IAI39 primosomal protein DnaI YP_002410685.1 5043426 R 585057 CDS YP_002410686.2 229598880 7151162 complement(5044073..5044546) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5044546 7151162 ECIAI39_4836 Escherichia coli IAI39 hypothetical protein YP_002410686.2 5044073 R 585057 CDS YP_002410687.1 218703058 7150460 complement(5044537..5045307) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 5045307 yjjP 7150460 yjjP Escherichia coli IAI39 hypothetical protein YP_002410687.1 5044537 R 585057 CDS YP_002410688.1 218703059 7154347 5045927..5046652 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 5046652 yjjQ 7154347 yjjQ Escherichia coli IAI39 putative DNA-binding transcriptional regulator YP_002410688.1 5045927 D 585057 CDS YP_002410689.1 218703060 7154348 5046664..5047287 1 NC_011750.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; DNA-binding transcriptional activator BglJ 5047287 bglJ 7154348 bglJ Escherichia coli IAI39 DNA-binding transcriptional activator BglJ YP_002410689.1 5046664 D 585057 CDS YP_002410690.1 218703061 7150860 complement(5047325..5048113) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11931550, 14756576, 3323834, 9990318; Product type c : carrier; ferric iron reductase involved in ferric hydroximate transport 5048113 fhuF 7150860 fhuF Escherichia coli IAI39 ferric iron reductase involved in ferric hydroximate transport YP_002410690.1 5047325 R 585057 CDS YP_002410691.1 218703062 7151320 5048143..5048490 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5048490 7151320 ECIAI39_4841 Escherichia coli IAI39 hypothetical protein YP_002410691.1 5048143 D 585057 CDS YP_002410692.1 218703063 7150585 complement(5049051..5050082) 1 NC_011750.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase 5050082 rsmC 7150585 rsmC Escherichia coli IAI39 16S ribosomal RNA m2G1207 methyltransferase YP_002410692.1 5049051 R 585057 CDS YP_002410693.1 218703064 7152744 5050185..5050598 1 NC_011750.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 5050598 holD 7152744 holD Escherichia coli IAI39 DNA polymerase III subunit psi YP_002410693.1 5050185 D 585057 CDS YP_002410694.1 218703065 7151670 5050567..5051013 1 NC_011750.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 5051013 rimI 7151670 rimI Escherichia coli IAI39 ribosomal-protein-alanine N-acetyltransferase YP_002410694.1 5050567 D 585057 CDS YP_002410695.1 218703066 7152634 5051028..5051705 1 NC_011750.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 5051705 yjjG 7152634 yjjG Escherichia coli IAI39 nucleotidase YP_002410695.1 5051028 D 585057 CDS YP_002410696.1 218703067 7154341 5052091..5053314 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative integrase 5053314 7154341 ECIAI39_4846 Escherichia coli IAI39 putative integrase YP_002410696.1 5052091 D 585057 CDS YP_002410697.1 218703068 7150462 5053487..5054740 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5054740 7150462 ECIAI39_4847 Escherichia coli IAI39 hypothetical protein YP_002410697.1 5053487 D 585057 CDS YP_002410698.1 218703069 7150463 complement(5055217..5055564) 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 5055564 yfdT 7150463 yfdT Escherichia coli IAI39 hypothetical protein YP_002410698.1 5055217 R 585057 CDS YP_002410699.1 218703070 7153856 complement(5055561..5056439) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phosphoadenosine phosphosulfate reductase from phage origin 5056439 7153856 ECIAI39_4849 Escherichia coli IAI39 putative phosphoadenosine phosphosulfate reductase from phage origin YP_002410699.1 5055561 R 585057 CDS YP_002410700.1 218703071 7150464 complement(5056461..5057018) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 5057018 yfdR 7150464 yfdR Escherichia coli IAI39 hypothetical protein YP_002410700.1 5056461 R 585057 CDS YP_002410701.1 218703072 7153855 complement(5057084..5057908) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 5057908 yfdQ 7153855 yfdQ Escherichia coli IAI39 hypothetical protein YP_002410701.1 5057084 R 585057 CDS YP_002410702.1 218703073 7153854 complement(5057974..5058522) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5058522 7153854 ECIAI39_4852 Escherichia coli IAI39 hypothetical protein YP_002410702.1 5057974 R 585057 CDS YP_002410703.1 218703074 7150465 complement(5059082..5059756) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12878731, 13129938, 9689094; Product type h : extrachromosomal origin; repressor protein phage e14; e14 prophage 5059756 ymfK 7150465 ymfK Escherichia coli IAI39 repressor protein phage e14; e14 prophage YP_002410703.1 5059082 R 585057 CDS YP_002410704.1 218703075 7154388 5059847..5060047 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA-binding transcriptional regulator; e14 prophage 5060047 ymfT 7154388 ymfT Escherichia coli IAI39 putative DNA-binding transcriptional regulator; e14 prophage YP_002410704.1 5059847 D 585057 CDS YP_002410705.1 218703076 7154389 5060309..5060635 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 5060635 7154389 ECIAI39_4856 Escherichia coli IAI39 transposase ORF A, IS629 YP_002410705.1 5060309 D 585057 CDS YP_002410706.1 218703077 7150466 5060632..5061522 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 5061522 7150466 ECIAI39_4857 Escherichia coli IAI39 transposase ORF B, IS629 YP_002410706.1 5060632 D 585057 CDS YP_002410707.1 218703078 7154390 5061952..5062788 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Immunity region from phage 5062788 7154390 ECIAI39_4860 Escherichia coli IAI39 Immunity region from phage YP_002410707.1 5061952 D 585057 CDS YP_002410708.1 218703079 7150468 5062781..5063017 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5063017 7150468 ECIAI39_4861 Escherichia coli IAI39 hypothetical protein YP_002410708.1 5062781 D 585057 CDS YP_002410709.1 218703080 7150469 5063014..5063832 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative replication protein from phage 5063832 7150469 ECIAI39_4862 Escherichia coli IAI39 putative replication protein from phage YP_002410709.1 5063014 D 585057 CDS YP_002410710.1 218703081 7150470 5064290..5064976 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage AdoMet-dependent methyltransferase 5064976 7150470 ECIAI39_4863 Escherichia coli IAI39 putative phage AdoMet-dependent methyltransferase YP_002410710.1 5064290 D 585057 CDS YP_002410711.1 218703082 7150471 5064973..5065299 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative LexA repressor 5065299 7150471 ECIAI39_4864 Escherichia coli IAI39 putative LexA repressor YP_002410711.1 5064973 D 585057 CDS YP_002410712.1 218703083 7150472 5065296..5065685 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Crossover junction endodeoxyribonuclease 5065685 rusA 7150472 rusA Escherichia coli IAI39 Crossover junction endodeoxyribonuclease YP_002410712.1 5065296 D 585057 CDS YP_002410713.1 218703084 7152764 5065705..5066514 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative KilA protein; KilA-N domain 5066514 7152764 ECIAI39_4866 Escherichia coli IAI39 putative KilA protein; KilA-N domain YP_002410713.1 5065705 D 585057 CDS YP_002410714.1 218703085 7150473 5066516..5067511 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5067511 7150473 ECIAI39_4867 Escherichia coli IAI39 hypothetical protein YP_002410714.1 5066516 D 585057 CDS YP_002410715.1 218703086 7150474 5067525..5068277 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative antitermination protein Q; Qin prophage 5068277 ydfT 7150474 ydfT Escherichia coli IAI39 putative antitermination protein Q; Qin prophage YP_002410715.1 5067525 D 585057 CDS YP_002410716.1 218703087 7153559 5068558..5068983 1 NC_011750.1 hypothetical protein 5068983 7153559 ECIAI39_4869 Escherichia coli IAI39 hypothetical protein YP_002410716.1 5068558 D 585057 CDS YP_002410717.1 218703088 7150475 5069183..5069410 1 NC_011750.1 hypothetical protein 5069410 7150475 ECIAI39_4870 Escherichia coli IAI39 hypothetical protein YP_002410717.1 5069183 D 585057 CDS YP_002410718.1 218703089 7150476 5069682..5070200 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5070200 7150476 ECIAI39_4871 Escherichia coli IAI39 hypothetical protein YP_002410718.1 5069682 D 585057 CDS YP_002410719.1 218703090 7150477 5070219..5071439 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase 5071439 7150477 ECIAI39_4872 Escherichia coli IAI39 putative transposase YP_002410719.1 5070219 D 585057 CDS YP_002410720.1 218703091 7150478 5071451..5072506 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA adenine methyltransferase ( DNA methylase) from phage origin 5072506 7150478 ECIAI39_4873 Escherichia coli IAI39 putative DNA adenine methyltransferase ( DNA methylase) from phage origin YP_002410720.1 5071451 D 585057 CDS YP_002410721.1 218703092 7150479 5072573..5072788 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019562; Product type pe : putative enzyme; putative phage lysis protein S; DLP12 prophage 5072788 essD 7150479 essD Escherichia coli IAI39 putative phage lysis protein S; DLP12 prophage YP_002410721.1 5072573 D 585057 CDS YP_002410722.1 218703093 7151240 5072788..5073285 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3017988; Product type pe : putative enzyme; putative lysozyme; DLP12 prophage 5073285 ybcS 7151240 ybcS Escherichia coli IAI39 putative lysozyme; DLP12 prophage YP_002410722.1 5072788 D 585057 CDS YP_002410723.1 218703094 7153302 5073270..5073749 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Endopeptidase from phage origin (Lysis protein Rz) 5073749 Rz 7153302 Rz Escherichia coli IAI39 Endopeptidase from phage origin (Lysis protein Rz) YP_002410723.1 5073270 D 585057 CDS YP_002410724.1 218703095 7152796 5074408..5074815 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5074815 7152796 ECIAI39_4877 Escherichia coli IAI39 hypothetical protein YP_002410724.1 5074408 D 585057 CDS YP_002410725.1 218703096 7150480 5074967..5075461 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 5075461 7150480 ECIAI39_4878 Escherichia coli IAI39 hypothetical protein YP_002410725.1 5074967 D 585057 CDS YP_002410726.1 218703097 7150481 5075461..5077563 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA packaging protein of putative prophage ( terminase large subunit) 5077563 7150481 ECIAI39_4879 Escherichia coli IAI39 putative DNA packaging protein of putative prophage ( terminase large subunit) YP_002410726.1 5075461 D 585057 CDS YP_002410727.1 218703098 7150482 5077554..5077772 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 5077772 7150482 ECIAI39_4880 Escherichia coli IAI39 hypothetical protein YP_002410727.1 5077554 D 585057 CDS YP_002410728.1 218703099 7150483 5077700..5079280 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative portal protein (head-tail preconnector protein) from putative prophage 5079280 7150483 ECIAI39_4881 Escherichia coli IAI39 putative portal protein (head-tail preconnector protein) from putative prophage YP_002410728.1 5077700 D 585057 CDS YP_002410729.1 218703100 7150484 5079129..5081252 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative ATP-dependent Clp protease proteolytic subunit 5081252 7150484 ECIAI39_4882 Escherichia coli IAI39 putative ATP-dependent Clp protease proteolytic subunit YP_002410729.1 5079129 D 585057 CDS YP_002410730.1 218703101 7150485 5081294..5081662 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 5081662 7150485 ECIAI39_4883 Escherichia coli IAI39 hypothetical protein YP_002410730.1 5081294 D 585057 CDS YP_002410731.1 218703102 7150486 5081655..5081930 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 5081930 7150486 ECIAI39_4884 Escherichia coli IAI39 hypothetical protein YP_002410731.1 5081655 D 585057 CDS YP_002410732.1 218703103 7150487 5081942..5082520 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein Z (GPZ) of prophage 5082520 7150487 ECIAI39_4885 Escherichia coli IAI39 minor tail protein Z (GPZ) of prophage YP_002410732.1 5081942 D 585057 CDS YP_002410733.1 218703104 7150488 5082505..5082918 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein U 5082918 7150488 ECIAI39_4886 Escherichia coli IAI39 minor tail protein U YP_002410733.1 5082505 D 585057 CDS YP_002410734.1 218703105 7150489 5082854..5083672 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail protein V 5083672 7150489 ECIAI39_4887 Escherichia coli IAI39 major tail protein V YP_002410734.1 5082854 D 585057 CDS YP_002410735.1 218703106 7150490 5083691..5084119 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative minor tail component of putative prophage 5084119 7150490 ECIAI39_4888 Escherichia coli IAI39 putative minor tail component of putative prophage YP_002410735.1 5083691 D 585057 CDS YP_002410736.1 218703107 7150491 5084128..5084457 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative minor tail protein T of putative prophage 5084457 7150491 ECIAI39_4889 Escherichia coli IAI39 putative minor tail protein T of putative prophage YP_002410736.1 5084128 D 585057 CDS YP_002410737.1 218703108 7150492 5084399..5087494 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail length tape measure protein from putative prophage 5087494 7150492 ECIAI39_4890 Escherichia coli IAI39 putative tail length tape measure protein from putative prophage YP_002410737.1 5084399 D 585057 CDS YP_002410738.1 218703109 7150493 5087494..5087823 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein M 5087823 7150493 ECIAI39_4891 Escherichia coli IAI39 minor tail protein M YP_002410738.1 5087494 D 585057 CDS YP_002410739.1 218703110 7150494 5087833..5088531 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein L 5088531 7150494 ECIAI39_4892 Escherichia coli IAI39 minor tail protein L YP_002410739.1 5087833 D 585057 CDS YP_002410740.1 218703111 7150495 5088537..5089280 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber component K of prophage 5089280 7150495 ECIAI39_4893 Escherichia coli IAI39 putative tail fiber component K of prophage YP_002410740.1 5088537 D 585057 CDS YP_002410741.1 218703112 7150496 5089178..5089825 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein I from putative prophage 5089825 7150496 ECIAI39_4894 Escherichia coli IAI39 tail assembly protein I from putative prophage YP_002410741.1 5089178 D 585057 CDS YP_002410742.1 218703113 7150497 5089886..5093584 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J 5093584 7150497 ECIAI39_4895 Escherichia coli IAI39 Host specificity protein J YP_002410742.1 5089886 D 585057 CDS YP_002410743.1 218703114 7150498 5093652..5094251 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Lom-like outer membrane protein of prophage 5094251 7150498 ECIAI39_4896 Escherichia coli IAI39 putative Lom-like outer membrane protein of prophage YP_002410743.1 5093652 D 585057 CDS YP_002410744.1 218703115 7150499 5094403..5096460 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 5096460 7150499 ECIAI39_4897 Escherichia coli IAI39 hypothetical protein YP_002410744.1 5094403 D 585057 CDS YP_002410745.1 218703116 7150500 5096457..5096735 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5096735 7150500 ECIAI39_4898 Escherichia coli IAI39 hypothetical protein YP_002410745.1 5096457 D 585057 CDS YP_002410746.1 218703117 7150501 5096745..5097038 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 5097038 7150501 ECIAI39_4899 Escherichia coli IAI39 hypothetical protein YP_002410746.1 5096745 D 585057 CDS YP_002410747.1 218703118 7150502 complement(5097290..5098666) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative retron-type reverse transcriptase 5098666 7150502 ECIAI39_4900 Escherichia coli IAI39 putative retron-type reverse transcriptase YP_002410747.1 5097290 R 585057 CDS YP_002410748.1 218703119 7150503 complement(5098638..5099342) 1 NC_011750.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5099342 7150503 ECIAI39_4901 Escherichia coli IAI39 hypothetical protein YP_002410748.1 5098638 R 585057 CDS YP_002410749.1 218703120 7150504 complement(5099434..5099535) 1 NC_011750.1 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; putative DNA damage-inducible protein of the DinI-like family from putative prophage (fragment) 5099535 7150504 ECIAI39_4902 Escherichia coli IAI39 putative DNA damage-inducible protein of the DinI-like family from putative prophage (fragment) YP_002410749.1 5099434 R 585057 CDS YP_002410750.1 218703121 7150505 5099846..5101459 1 NC_011750.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 5101459 prfC 7150505 prfC Escherichia coli IAI39 peptide chain release factor 3 YP_002410750.1 5099846 D 585057 CDS YP_002410751.1 218703122 7152474 5101852..5102457 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1317380, 8253679, 9298646, 9600841; Product type cp : cell process; periplasmic protein 5102457 osmY 7152474 osmY Escherichia coli IAI39 periplasmic protein YP_002410751.1 5101852 D 585057 CDS YP_002410752.1 218703123 7152311 5102566..5102745 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5102745 ytjA 7152311 ytjA Escherichia coli IAI39 hypothetical protein YP_002410752.1 5102566 D 585057 CDS YP_002410753.1 218703124 7154584 5102867..5103940 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative esterase 5103940 yjjU 7154584 yjjU Escherichia coli IAI39 putative esterase YP_002410753.1 5102867 D 585057 CDS YP_002410754.1 218703125 7154349 5103937..5104716 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative deoxyribonuclease YjjV 5104716 yjjV 7154349 yjjV Escherichia coli IAI39 putative deoxyribonuclease YjjV YP_002410754.1 5103937 D 585057 CDS YP_002410755.1 218703126 7154350 5104776..5105306 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 5105306 7154350 ECIAI39_4908 Escherichia coli IAI39 transposase ORF A, IS1397 YP_002410755.1 5104776 D 585057 CDS YP_002410756.1 218703127 7150506 5105411..5106133 1 NC_011750.1 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 5106133 7150506 ECIAI39_4909 Escherichia coli IAI39 transposase ORF B, IS3 family, IS150 group YP_002410756.1 5105411 D 585057 CDS YP_002410757.1 218703128 7150507 complement(5106269..5107132) 1 NC_011750.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative pyruvate formate lyase activating enzyme 5107132 yjjW 7150507 yjjW Escherichia coli IAI39 putative pyruvate formate lyase activating enzyme YP_002410757.1 5106269 R 585057 CDS YP_002410758.1 218703129 7154343 5108914..5109693 1 NC_011750.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 5109693 deoC 7154343 deoC Escherichia coli IAI39 deoxyribose-phosphate aldolase YP_002410758.1 5108914 D 585057 CDS YP_002410759.1 218703130 7151119 5109771..5111093 1 NC_011750.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 5111093 deoA 7151119 deoA Escherichia coli IAI39 thymidine phosphorylase YP_002410759.1 5109771 D 585057 CDS YP_002410760.1 218703131 7151117 5111145..5112368 1 NC_011750.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 5112368 deoB 7151117 deoB Escherichia coli IAI39 phosphopentomutase YP_002410760.1 5111145 D 585057 CDS YP_002410761.1 218703132 7151118 5112425..5113144 1 NC_011750.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 5113144 deoD 7151118 deoD Escherichia coli IAI39 purine nucleoside phosphorylase YP_002410761.1 5112425 D 585057 CDS YP_002410762.1 218703133 7151120 complement(5113305..5113568) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; putative transcriptional regulator 5113568 7151120 ECIAI39_4917 Escherichia coli IAI39 putative transcriptional regulator YP_002410762.1 5113305 R 585057 CDS YP_002410763.1 218703134 7150508 complement(5113600..5114616) 1 NC_011750.1 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; lipoate-protein ligase A 5114616 lplA 7150508 lplA Escherichia coli IAI39 lipoate-protein ligase A YP_002410763.1 5113600 R 585057 CDS YP_002410764.1 218703135 7151961 complement(5114644..5115288) 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2684780; hypothetical protein 5115288 ytjB 7151961 ytjB Escherichia coli IAI39 hypothetical protein YP_002410764.1 5114644 R 585057 CDS YP_002410765.1 218703136 7154585 5115394..5116362 1 NC_011750.1 catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 5116362 serB 7154585 serB Escherichia coli IAI39 phosphoserine phosphatase YP_002410765.1 5115394 D 585057 CDS YP_002410766.1 218703137 7152831 5116411..5117793 1 NC_011750.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 5117793 radA 7152831 radA Escherichia coli IAI39 DNA repair protein RadA YP_002410766.1 5116411 D 585057 CDS YP_002410767.1 218703138 7152565 5117814..5119046 1 NC_011750.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 5119046 nadR 7152565 nadR Escherichia coli IAI39 nicotinamide-nucleotide adenylyltransferase YP_002410767.1 5117814 D 585057 CDS YP_002410768.1 218703139 7152170 5119080..5119364 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5119364 7152170 ECIAI39_4923 Escherichia coli IAI39 hypothetical protein YP_002410768.1 5119080 D 585057 CDS YP_002410769.1 218703140 7150509 complement(5119420..5121087) 1 NC_011750.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein 5121087 yjjK 7150509 yjjK Escherichia coli IAI39 putative ABC transporter ATP-binding protein YP_002410769.1 5119420 R 585057 CDS YP_002410770.1 218703141 7154344 5121298..5123235 1 NC_011750.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 5123235 slt 7154344 slt Escherichia coli IAI39 lytic murein transglycosylase YP_002410770.1 5121298 D 585057 CDS YP_002410771.1 218703142 7152859 5123325..5123651 1 NC_011750.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 5123651 trpR 7152859 trpR Escherichia coli IAI39 Trp operon repressor YP_002410771.1 5123325 D 585057 CDS YP_002410772.1 218703143 7153037 complement(5123645..5124169) 1 NC_011750.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase 5124169 yjjX 7153037 yjjX Escherichia coli IAI39 NTPase YP_002410772.1 5123645 R 585057 CDS YP_002410773.1 218703144 7154352 5124212..5124859 1 NC_011750.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 5124859 ytjC 7154352 ytjC Escherichia coli IAI39 phosphoglycerate mutase YP_002410773.1 5124212 D 585057 CDS YP_002410774.1 218703145 7154586 complement(5124856..5125725) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20264525, 20309711, 93194823, 96405618, 8449900; Product type r : regulator; DNA-binding transcriptional activator 5125725 rob 7154586 rob Escherichia coli IAI39 DNA-binding transcriptional activator YP_002410774.1 5124856 R 585057 CDS YP_002410775.1 218703146 7152664 5125936..5126409 1 NC_011750.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3531171, 8449900; hypothetical protein 5126409 creA 7152664 creA Escherichia coli IAI39 hypothetical protein YP_002410775.1 5125936 D 585057 CDS YP_002410776.1 218703147 7150994 5126422..5127111 1 NC_011750.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 5127111 creB 7150994 creB Escherichia coli IAI39 DNA-binding response regulator CreB YP_002410776.1 5126422 D 585057 CDS YP_002410777.1 218703148 7150995 5127111..5128535 1 NC_011750.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 5128535 creC 7150995 creC Escherichia coli IAI39 sensory histidine kinase CreC YP_002410777.1 5127111 D 585057 CDS YP_002410778.1 218703149 7150996 5128593..5129945 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88216172, 2835585, 2984198, 3531171; Product type m : membrane component; hypothetical protein 5129945 creD 7150996 creD Escherichia coli IAI39 hypothetical protein YP_002410778.1 5128593 D 585057 CDS YP_002410779.1 218703150 7150997 complement(5130005..5130721) 1 NC_011750.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15028693, 21167794, 21317451, 91008980, 91358353, 92380937, 9514749, 9632255, 2984198, 7565118, 9298646; Product type r : regulator; two-component response regulator 5130721 arcA 7150997 arcA Escherichia coli IAI39 two-component response regulator YP_002410779.1 5130005 R 585057 CDS YP_002410780.1 218703151 7150756 5131357..5132043 1 NC_011750.1 member of the SPOUT superfamily of methyltransferases; putative RNA methyltransferase 5132043 yjtD 7150756 yjtD Escherichia coli IAI39 putative RNA methyltransferase YP_002410780.1 5131357 D 585057 CDS