-- dump date 20140619_082405 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 585057000001 SEQ_END SEQ_END NC_011750.1 5132068 5132068 DR NC_011750.1; contig end 5132068..5132068 Escherichia coli IAI39 YP_002406049.1 CDS thrL NC_011750.1 189 254 D involved in threonine biosynthesis; controls the expression of the thrLABC operon; thr operon leader peptide 189..254 Escherichia coli IAI39 7150518 YP_002406050.1 CDS thrA NC_011750.1 335 2797 D multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 335..2797 Escherichia coli IAI39 7152980 YP_002406051.1 CDS thrB NC_011750.1 2799 3731 D catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 2799..3731 Escherichia coli IAI39 7152977 YP_002406052.1 CDS thrC NC_011750.1 3732 5018 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 3732..5018 Escherichia coli IAI39 7152978 YP_002406053.1 CDS yaaX NC_011750.1 5232 5528 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5232..5528 Escherichia coli IAI39 7152979 YP_002406054.1 CDS yaaA NC_011750.1 5568 6344 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5568..6344) Escherichia coli IAI39 7153196 YP_002406055.1 CDS yaaJ NC_011750.1 6414 7844 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino acid sodium/proton transporter complement(6414..7844) Escherichia coli IAI39 7153191 YP_002406056.1 CDS talB NC_011750.1 8123 9076 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8332529, 92334977, 11298760, 7592346, 8805555, 9007983, 9298646; Product type e : enzyme; transaldolase B 8123..9076 Escherichia coli IAI39 7153194 YP_002406057.1 CDS mogA NC_011750.1 9191 9778 D forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 9191..9778 Escherichia coli IAI39 7152939 YP_002406058.1 CDS yaaH NC_011750.1 9813 10379 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(9813..10379) Escherichia coli IAI39 7152110 YP_002406059.1 CDS htpY NC_011750.1 10528 11241 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8478327; Product type r : regulator; hypothetical protein complement(10528..11241) Escherichia coli IAI39 7153192 YP_002406060.1 CDS yaaI NC_011750.1 11267 11671 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(11267..11671) Escherichia coli IAI39 7151688 YP_002406061.1 CDS dnaK NC_011750.1 12047 13963 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 12047..13963 Escherichia coli IAI39 7153193 YP_002406062.1 CDS dnaJ NC_011750.1 14052 15182 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 14052..15182 Escherichia coli IAI39 7153014 YP_002406063.1 CDS ECIAI39_0015 NC_011750.1 16050 16811 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 16050..16811 Escherichia coli IAI39 7152875 YP_002406064.1 CDS ECIAI39_0016 NC_011750.1 16795 18324 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Cerebroside-sulfatase 16795..18324 Escherichia coli IAI39 7149503 YP_002406065.1 CDS ECIAI39_0017 NC_011750.1 18418 19698 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 18418..19698 Escherichia coli IAI39 7149504 YP_002406066.1 CDS nhaA NC_011750.1 19950 21116 D exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 19950..21116 Escherichia coli IAI39 7149505 YP_002406067.1 CDS nhaR NC_011750.1 21176 22081 D Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 21176..22081 Escherichia coli IAI39 7152220 YP_002406068.1 CDS ECIAI39_0020 NC_011750.1 22119 23078 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(22119..23078) Escherichia coli IAI39 7152222 YP_002406069.1 CDS ECIAI39_0021 NC_011750.1 23091 25541 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative fimbrial biogenesis outer membrane usher protein complement(23091..25541) Escherichia coli IAI39 7149506 YP_002406070.1 CDS ECIAI39_0022 NC_011750.1 25554 26237 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative membrane-associated pilin chaperone complement(25554..26237) Escherichia coli IAI39 7149507 YP_002406071.1 CDS ECIAI39_0023 NC_011750.1 26287 26820 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like protein complement(26287..26820) Escherichia coli IAI39 7149508 YP_002406072.1 CDS ECIAI39_0024 NC_011750.1 27121 28542 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(27121..28542) Escherichia coli IAI39 7149509 YP_002406073.1 CDS rpsT NC_011750.1 29026 29289 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(29026..29289) Escherichia coli IAI39 7149510 YP_002406074.1 CDS ribF NC_011750.1 29618 30559 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 29618..30559 Escherichia coli IAI39 7152732 YP_002406075.1 CDS ileS NC_011750.1 30602 33418 D IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 30602..33418 Escherichia coli IAI39 7152630 YP_002406076.1 CDS lspA NC_011750.1 33418 33912 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 33418..33912 Escherichia coli IAI39 7151762 YP_002406077.1 CDS fkpB NC_011750.1 34000 34449 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97332650, 2011499; Product type e : enzyme; FKBP-type peptidyl-prolyl cis-trans isomerase 34000..34449 Escherichia coli IAI39 7151975 YP_002406078.1 CDS ispH NC_011750.1 34451 35401 D catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 34451..35401 Escherichia coli IAI39 7151346 YP_002406079.1 CDS rihC NC_011750.1 35467 36381 D catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 35467..36381 Escherichia coli IAI39 7151857 YP_002406080.1 CDS dapB NC_011750.1 36548 37369 D catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 36548..37369 Escherichia coli IAI39 7152633 YP_002406081.1 CDS carA NC_011750.1 37825 38973 D catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 37825..38973 Escherichia coli IAI39 7151085 YP_002406082.1 CDS carB NC_011750.1 38991 42212 D four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 38991..42212 Escherichia coli IAI39 7150902 YP_002406083.1 CDS caiF NC_011750.1 42473 42868 D regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; DNA-binding transcriptional activator CaiF 42473..42868 Escherichia coli IAI39 7150903 YP_002406084.1 CDS caiE NC_011750.1 42987 43577 R involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE complement(42987..43577) Escherichia coli IAI39 7150899 YP_002406085.2 CDS caiD NC_011750.1 43583 44368 R catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase complement(43583..44368) Escherichia coli IAI39 7150898 YP_002406086.1 CDS caiC NC_011750.1 44477 46045 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15731894, 97189569, 7815937; Product type e : enzyme; putative crotonobetaine/carnitine-CoA ligase complement(44477..46045) Escherichia coli IAI39 7150897 YP_002406087.1 CDS caiB NC_011750.1 46103 47320 R catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine; crotonobetainyl-CoA:carnitine CoA-transferase complement(46103..47320) Escherichia coli IAI39 7150896 YP_002406088.1 CDS caiA NC_011750.1 47449 48591 R catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase complement(47449..48591) Escherichia coli IAI39 7150895 YP_002406089.1 CDS caiT NC_011750.1 48622 50136 R catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter complement(48622..50136) Escherichia coli IAI39 7150894 YP_002406090.1 CDS fixA NC_011750.1 50609 51379 D required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; putative electron transfer flavoprotein FixA 50609..51379 Escherichia coli IAI39 7150900 YP_002406091.1 CDS fixB NC_011750.1 51394 52335 D involved in electron transfer during carnitine metabolism; putative electron transfer flavoprotein FixB 51394..52335 Escherichia coli IAI39 7151340 YP_002406092.1 CDS fixC NC_011750.1 52386 53672 D FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; putative oxidoreductase 52386..53672 Escherichia coli IAI39 7151341 YP_002406093.1 CDS fixX NC_011750.1 53669 53956 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96066354, 12081978; Product type pc : putative carrier; putative 4Fe-4S ferredoxin 53669..53956 Escherichia coli IAI39 7151342 YP_002406094.1 CDS yaaU NC_011750.1 54014 55345 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 54014..55345 Escherichia coli IAI39 7151343 YP_002406095.1 CDS kefF NC_011750.1 55453 55983 D Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 55453..55983 Escherichia coli IAI39 7153195 YP_002406096.1 CDS kefC NC_011750.1 55976 57838 D transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 55976..57838 Escherichia coli IAI39 7151896 YP_002406097.1 CDS folA NC_011750.1 58030 58509 D catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 58030..58509 Escherichia coli IAI39 7151895 YP_002406098.1 CDS ECIAI39_0050 NC_011750.1 58595 58828 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative antitoxin of gyrase inhibiting toxin-antitoxin system 58595..58828 Escherichia coli IAI39 7151397 YP_002406099.1 CDS ECIAI39_0051 NC_011750.1 58831 59145 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative toxin of gyrase inhibiting toxin-antitoxin system 58831..59145 Escherichia coli IAI39 7149511 YP_002406100.1 CDS apaH NC_011750.1 59142 59990 R hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase complement(59142..59990) Escherichia coli IAI39 7149512 YP_002406101.1 CDS apaG NC_011750.1 59997 60374 R protein associated with Co2+ and Mg2+ efflux; ApaG protein complement(59997..60374) Escherichia coli IAI39 7150740 YP_002406102.1 CDS ksgA NC_011750.1 60377 61198 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(60377..61198) Escherichia coli IAI39 7150739 YP_002406103.1 CDS pdxA NC_011750.1 61195 62184 R catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase complement(61195..62184) Escherichia coli IAI39 7151910 YP_002406104.1 CDS surA NC_011750.1 62184 63470 R Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA complement(62184..63470) Escherichia coli IAI39 7152355 YP_002406105.1 CDS imp NC_011750.1 63523 65877 R determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein complement(63523..65877) Escherichia coli IAI39 7152932 YP_002406106.1 CDS djlA NC_011750.1 66132 66947 D functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 66132..66947 Escherichia coli IAI39 7151775 YP_002406107.1 CDS ECIAI39_0059 NC_011750.1 67021 67551 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 67021..67551 Escherichia coli IAI39 7151144 YP_002406108.1 CDS ECIAI39_0060 NC_011750.1 67656 68378 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 67656..68378 Escherichia coli IAI39 7149513 YP_002406109.1 CDS rluA NC_011750.1 68500 69159 R catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A complement(68500..69159) Escherichia coli IAI39 7149514 YP_002406110.1 CDS hepA NC_011750.1 69171 72077 R transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA complement(69171..72077) Escherichia coli IAI39 7152641 YP_002406111.1 CDS polB NC_011750.1 72241 74592 R Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II complement(72241..74592) Escherichia coli IAI39 7151636 YP_002406112.1 CDS araD NC_011750.1 74667 75362 R catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase complement(74667..75362) Escherichia coli IAI39 7152440 YP_002406113.1 CDS araA NC_011750.1 75477 76979 R catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase complement(75477..76979) Escherichia coli IAI39 7150750 YP_002406114.1 CDS araB NC_011750.1 76990 78690 R catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase complement(76990..78690) Escherichia coli IAI39 7150747 YP_002406115.1 CDS araC NC_011750.1 78978 79874 D positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; DNA-binding transcriptional regulator AraC 78978..79874 Escherichia coli IAI39 7150748 YP_002406116.1 CDS ECIAI39_0068 NC_011750.1 80385 81236 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 80385..81236 Escherichia coli IAI39 7150749 YP_002406117.1 CDS ECIAI39_0069 NC_011750.1 81243 81665 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 81243..81665 Escherichia coli IAI39 7149515 YP_002406118.1 CDS yabI NC_011750.1 81820 82584 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 81820..82584 Escherichia coli IAI39 7149516 YP_002406119.1 CDS thiQ NC_011750.1 82666 83364 R with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding subunit complement(82666..83364) Escherichia coli IAI39 7153197 YP_002406120.1 CDS thiP NC_011750.1 83348 84958 R permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein complement(83348..84958) Escherichia coli IAI39 7152975 YP_002406121.1 CDS tbpA NC_011750.1 84934 85917 R part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit complement(84934..85917) Escherichia coli IAI39 7152974 YP_002406122.1 CDS ECIAI39_0074 NC_011750.1 86288 86857 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 86288..86857 Escherichia coli IAI39 7150531 YP_002406123.1 CDS sgrR NC_011750.1 87087 88766 R activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR complement(87087..88766) Escherichia coli IAI39 7149517 YP_002406124.1 CDS leuD NC_011750.1 89073 89678 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(89073..89678) Escherichia coli IAI39 7152848 YP_002406125.1 CDS leuC NC_011750.1 89689 91089 R dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit complement(89689..91089) Escherichia coli IAI39 7151927 YP_002406126.1 CDS leuB NC_011750.1 91092 92183 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(91092..92183) Escherichia coli IAI39 7151926 YP_002406127.1 CDS leuA NC_011750.1 92183 93754 R catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase complement(92183..93754) Escherichia coli IAI39 7151925 YP_002406128.1 CDS leuL NC_011750.1 93847 93933 R involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide complement(93847..93933) Escherichia coli IAI39 7150539 YP_002406129.1 CDS leuO NC_011750.1 94592 95536 D activator for leuABCD operon; member of LysR family of transcriptional activators; leucine transcriptional activator 94592..95536 Escherichia coli IAI39 7151928 YP_002406130.1 CDS ilvI NC_011750.1 95852 97576 D catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 95852..97576 Escherichia coli IAI39 7151929 YP_002406131.1 CDS ilvH NC_011750.1 97579 98070 D with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 97579..98070 Escherichia coli IAI39 7151770 YP_002406132.1 CDS fruR NC_011750.1 98250 99254 D binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 98250..99254 Escherichia coli IAI39 7151769 YP_002406133.1 CDS mraZ NC_011750.1 99856 100314 D MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 99856..100314 Escherichia coli IAI39 7151422 YP_002406134.1 CDS mraW NC_011750.1 100316 101257 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20042184, 10493123, 2187182, 6350821; Product type e : enzyme; S-adenosyl-methyltransferase MraW 100316..101257 Escherichia coli IAI39 7152121 YP_002406135.1 CDS ftsL NC_011750.1 101254 101619 D membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 101254..101619 Escherichia coli IAI39 7152119 YP_002406136.1 CDS ftsI NC_011750.1 101635 103401 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91072213, 92202178, 94095121, 9603865, 9614966, 1332942, 1447153, 2198024, 2677607, 2681146, 3049550, 3911028, 6350821; Product type e : enzyme; transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3) 101635..103401 Escherichia coli IAI39 7151439 YP_002406137.1 CDS murE NC_011750.1 103388 104875 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 103388..104875 Escherichia coli IAI39 7151437 YP_002406138.1 CDS murF NC_011750.1 104872 106230 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88273095, 90248455, 91310568, 97128642, 11090285, 2668880, 9166795; Product type e : enzyme; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 104872..106230 Escherichia coli IAI39 7152149 YP_002406139.1 CDS mraY NC_011750.1 106224 107306 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 106224..107306 Escherichia coli IAI39 7152150 YP_002406140.1 CDS murD NC_011750.1 107309 108625 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 107309..108625 Escherichia coli IAI39 7152120 YP_002406141.1 CDS ftsW NC_011750.1 108625 109869 D integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 108625..109869 Escherichia coli IAI39 7152148 YP_002406142.1 CDS murG NC_011750.1 109866 110933 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 109866..110933 Escherichia coli IAI39 7151442 YP_002406143.1 CDS murC NC_011750.1 110987 112462 D Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 110987..112462 Escherichia coli IAI39 7152151 YP_002406144.1 CDS ddl NC_011750.1 112455 113375 D D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 112455..113375 Escherichia coli IAI39 7152147 YP_002406145.1 CDS ftsQ NC_011750.1 113377 114207 D involved in septum formation; cell division protein FtsQ 113377..114207 Escherichia coli IAI39 7151103 YP_002406146.1 CDS ftsA NC_011750.1 114204 115466 D ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 114204..115466 Escherichia coli IAI39 7151441 YP_002406147.1 CDS ftsZ NC_011750.1 115528 116679 D GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 115528..116679 Escherichia coli IAI39 7151433 YP_002406148.1 CDS lpxC NC_011750.1 116780 117697 D zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 116780..117697 Escherichia coli IAI39 7151445 YP_002406149.1 CDS secM NC_011750.1 117928 118440 D secM translational pause allows for the initiation of secA translation; SecA regulator SecM 117928..118440 Escherichia coli IAI39 7151967 YP_002406150.1 CDS secA NC_011750.1 118502 121207 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 118502..121207 Escherichia coli IAI39 7152824 YP_002406151.1 CDS mutT NC_011750.1 121267 121665 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10218109, 89264540, 90136514, 91225007, 97444511, 1309939, 2841285, 3033442, 3288626, 7578113, 9063868; Product type e : enzyme; nucleoside triphosphate pyrophosphohydrolase 121267..121665 Escherichia coli IAI39 7152818 YP_002406152.1 CDS yacF NC_011750.1 121960 122703 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(121960..122703) Escherichia coli IAI39 7152159 YP_002406153.1 CDS coaE NC_011750.1 122703 123323 R catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase complement(122703..123323) Escherichia coli IAI39 7153199 YP_002406154.1 CDS guaC NC_011750.1 123548 124591 D catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 123548..124591 Escherichia coli IAI39 7150975 YP_002406155.1 CDS hofC NC_011750.1 124626 125828 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96099298, 2904262, 7959070; Product type s : structure; type IV pilin biogenesis protein complement(124626..125828) Escherichia coli IAI39 7151598 YP_002406156.1 CDS hofB NC_011750.1 125818 127203 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96099298, 7959070; Product type pt : putative transporter; hypothetical protein complement(125818..127203) Escherichia coli IAI39 7151665 YP_002406157.1 CDS ppdD NC_011750.1 127213 127653 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20100782, 20271862, 96099298, 7959070; Product type ps : putative structure; putative major pilin subunit complement(127213..127653) Escherichia coli IAI39 7151664 YP_002406158.1 CDS nadC NC_011750.1 127856 128749 R catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase complement(127856..128749) Escherichia coli IAI39 7152457 YP_002406159.1 CDS ampD NC_011750.1 128837 129388 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90113890, 95047240, 2607970, 7959070; Product type e : enzyme; N-acetyl-anhydromuranmyl-L-alanine amidase 128837..129388 Escherichia coli IAI39 7152167 YP_002406160.1 CDS ampE NC_011750.1 129385 130239 D involved in regulation of beta-lactamase; putative signaling protein; regulatory protein AmpE 129385..130239 Escherichia coli IAI39 7150730 YP_002406161.1 CDS aroP NC_011750.1 130282 131655 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1104763, 90174991, 9150230; Product type t : transporter; aromatic amino acid transporter complement(130282..131655) Escherichia coli IAI39 7150731 YP_002406162.1 CDS pdhR NC_011750.1 132196 132960 D activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 132196..132960 Escherichia coli IAI39 7150786 YP_002406163.1 CDS aceE NC_011750.1 133121 135784 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 133121..135784 Escherichia coli IAI39 7153012 YP_002406164.1 CDS aceF NC_011750.1 135799 137691 D E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 135799..137691 Escherichia coli IAI39 7150662 YP_002406165.1 CDS lpd NC_011750.1 137899 139323 D E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 137899..139323 Escherichia coli IAI39 7150663 YP_002406166.1 CDS yacH NC_011750.1 139394 141247 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(139394..141247) Escherichia coli IAI39 7151957 YP_002406167.1 CDS acnB NC_011750.1 141602 144199 D catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 141602..144199 Escherichia coli IAI39 7153200 YP_002406168.1 CDS yacL NC_011750.1 144374 144736 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2666401, 7567469; hypothetical protein 144374..144736 Escherichia coli IAI39 7150667 YP_002406169.1 CDS speD NC_011750.1 144774 145568 R S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase complement(144774..145568) Escherichia coli IAI39 7153201 YP_002406170.1 CDS speE NC_011750.1 145584 146450 R catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase complement(145584..146450) Escherichia coli IAI39 7152882 YP_002406171.1 CDS yacC NC_011750.1 146556 147074 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2666401; hypothetical protein complement(146556..147074) Escherichia coli IAI39 7152883 YP_002406172.1 CDS cueO NC_011750.1 147069 148619 D laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 147069..148619 Escherichia coli IAI39 7153198 YP_002406173.1 CDS gcd NC_011750.1 148666 151056 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10359647, 11604400, 14612441, 91035240, 93123180, 93286127; Product type e : enzyme; glucose dehydrogenase complement(148666..151056) Escherichia coli IAI39 7151026 YP_002406174.1 CDS hpt NC_011750.1 151262 151798 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 13808016, 339828, 6787390, 6801015, 12070315; Product type e : enzyme; hypoxanthine phosphoribosyltransferase 151262..151798 Escherichia coli IAI39 7151493 YP_002406175.1 CDS can NC_011750.1 151839 152501 R catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase complement(151839..152501) Escherichia coli IAI39 7151672 YP_002406176.1 CDS yadG NC_011750.1 152610 153536 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 152610..153536 Escherichia coli IAI39 7150901 YP_002406177.1 CDS yadH NC_011750.1 153533 154303 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10474187; Product type pt : putative transporter; putative ABC transporter membrane protein 153533..154303 Escherichia coli IAI39 7153207 YP_002406178.1 CDS yadI NC_011750.1 154408 154848 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative PTS Enzyme IIA 154408..154848 Escherichia coli IAI39 7153208 YP_002406179.1 CDS yadE NC_011750.1 154912 156141 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported polysaccharide deacetylase 154912..156141 Escherichia coli IAI39 7153209 YP_002406180.1 CDS panD NC_011750.1 156145 156525 R Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase complement(156145..156525) Escherichia coli IAI39 7153206 YP_002406181.1 CDS yadD NC_011750.1 156799 157731 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11319082; Product type pe : putative enzyme; putative transposase 156799..157731 Escherichia coli IAI39 7152325 YP_002406182.1 CDS panC NC_011750.1 158091 158942 R catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase complement(158091..158942) Escherichia coli IAI39 7153205 YP_002406183.1 CDS panB NC_011750.1 158954 159748 R catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase complement(158954..159748) Escherichia coli IAI39 7152324 YP_002406184.1 CDS ECIAI39_0137 NC_011750.1 160377 160703 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 160377..160703 Escherichia coli IAI39 7153203 YP_002406185.1 CDS ECIAI39_0138 NC_011750.1 160700 161590 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 160700..161590 Escherichia coli IAI39 7149518 YP_002406186.1 CDS yadK NC_011750.1 162479 163075 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein complement(162479..163075) Escherichia coli IAI39 7153204 YP_002406187.1 CDS yadL NC_011750.1 163102 163707 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein complement(163102..163707) Escherichia coli IAI39 7153210 YP_002406188.1 CDS yadM NC_011750.1 163719 164261 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein complement(163719..164261) Escherichia coli IAI39 7153211 YP_002406189.1 CDS htrE NC_011750.1 164408 166903 R similar to the fimbrial usher protein PapC; putative outer membrane usher protein complement(164408..166903) Escherichia coli IAI39 7153212 YP_002406190.1 CDS ecpD NC_011750.1 166938 167678 R Evidence 2b : Function of strongly homologous gene; PubMedId : 93352405, 8102362, 15561151; Product type f : factor; putative chaperone protein EcpD complement(166938..167678) Escherichia coli IAI39 7151689 YP_002406191.1 CDS yadN NC_011750.1 167783 168367 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein complement(167783..168367) Escherichia coli IAI39 7151201 YP_002406192.1 CDS folK NC_011750.1 168738 169217 R catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase complement(168738..169217) Escherichia coli IAI39 7153213 YP_002406193.1 CDS pcnB NC_011750.1 169214 170632 R Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase I complement(169214..170632) Escherichia coli IAI39 7151402 YP_002406194.1 CDS yadB NC_011750.1 170671 171597 R this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase complement(170671..171597) Escherichia coli IAI39 7152353 YP_002406195.1 CDS dksA NC_011750.1 171634 172089 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15294157, 90202727, 2013578, 9298646, 9600841; Product type r : regulator; RNA polymerase-binding transcription factor complement(171634..172089) Escherichia coli IAI39 7153202 YP_002406196.1 CDS sfsA NC_011750.1 172267 172971 R Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A complement(172267..172971) Escherichia coli IAI39 7151147 YP_002406197.1 CDS ligT NC_011750.1 172986 173516 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97094878; Product type e : enzyme; 2'-5' RNA ligase complement(172986..173516) Escherichia coli IAI39 7152842 YP_002406198.1 CDS hrpB NC_011750.1 173590 176019 D similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 173590..176019 Escherichia coli IAI39 7151937 YP_002406199.1 CDS mrcB NC_011750.1 176113 178647 D bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 176113..178647 Escherichia coli IAI39 7151674 YP_002406200.1 CDS fhuA NC_011750.1 178867 181116 D involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 178867..181116 Escherichia coli IAI39 7152123 YP_002406201.1 CDS fhuC NC_011750.1 181167 181964 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding subunit 181167..181964 Escherichia coli IAI39 7151314 YP_002406202.1 CDS fhuD NC_011750.1 181964 182854 D Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 181964..182854 Escherichia coli IAI39 7151316 YP_002406203.1 CDS fhuB NC_011750.1 182851 184833 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 182851..184833 Escherichia coli IAI39 7151317 YP_002406204.1 CDS hemL NC_011750.1 184868 186148 R Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase complement(184868..186148) Escherichia coli IAI39 7151315 YP_002406205.1 CDS clcA NC_011750.1 186373 187794 D Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 186373..187794 Escherichia coli IAI39 7151632 YP_002406206.1 CDS yadR NC_011750.1 187876 188220 D essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 187876..188220 Escherichia coli IAI39 7150960 YP_002406207.1 CDS yadS NC_011750.1 188267 188890 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(188267..188890) Escherichia coli IAI39 7153214 YP_002406208.1 CDS btuF NC_011750.1 188928 189728 R solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF complement(188928..189728) Escherichia coli IAI39 7153215 YP_002406209.1 CDS pfs NC_011750.1 189721 190419 R enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase complement(189721..190419) Escherichia coli IAI39 7150882 YP_002406210.1 CDS dgt NC_011750.1 190503 192020 D forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 190503..192020 Escherichia coli IAI39 7152376 YP_002406211.1 CDS degP NC_011750.1 192150 193574 D protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 192150..193574 Escherichia coli IAI39 7151132 YP_002406212.1 CDS cdaR NC_011750.1 193729 194886 D regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization; carbohydrate diacid transcriptional activator CdaR 193729..194886 Escherichia coli IAI39 7151114 YP_002406213.1 CDS yaeH NC_011750.1 194940 195326 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(194940..195326) Escherichia coli IAI39 7150919 YP_002406214.1 CDS dapD NC_011750.1 195641 196465 R catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase complement(195641..196465) Escherichia coli IAI39 7153218 YP_002406215.1 CDS glnD NC_011750.1 196496 199168 R catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase complement(196496..199168) Escherichia coli IAI39 7151086 YP_002406216.1 CDS map NC_011750.1 199230 200024 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase complement(199230..200024) Escherichia coli IAI39 7151525 YP_002406217.1 CDS rpsB NC_011750.1 200392 201117 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 200392..201117 Escherichia coli IAI39 7152935 YP_002406218.1 CDS tsf NC_011750.1 201252 202103 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 201252..202103 Escherichia coli IAI39 7152714 YP_002406219.1 CDS pyrH NC_011750.1 202250 202975 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 202250..202975 Escherichia coli IAI39 7153046 YP_002406220.1 CDS ECIAI39_0174 NC_011750.1 202965 203243 R hypothetical protein complement(202965..203243) Escherichia coli IAI39 7152554 YP_002406221.1 CDS frr NC_011750.1 203125 203682 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 203125..203682 Escherichia coli IAI39 7149520 YP_002406222.1 CDS dxr NC_011750.1 203774 204970 D catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 203774..204970 Escherichia coli IAI39 7151417 YP_002406223.1 CDS ispU NC_011750.1 205156 205917 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 205156..205917 Escherichia coli IAI39 7151189 YP_002406224.1 CDS cdsA NC_011750.1 205930 206787 D catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 205930..206787 Escherichia coli IAI39 7151858 YP_002406225.1 CDS yaeL NC_011750.1 206799 208151 D catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 206799..208151 Escherichia coli IAI39 7150922 YP_002406226.1 CDS yaeT NC_011750.1 208181 210613 D part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 208181..210613 Escherichia coli IAI39 7153220 YP_002406227.1 CDS hlpA NC_011750.1 210735 211220 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15101556, 90201355, 97032152, 99386928, 1987124, 2843433, 9298646, 2167239; Product type f : factor; periplasmic chaperone 210735..211220 Escherichia coli IAI39 7153224 YP_002406228.1 CDS lpxD NC_011750.1 211224 212249 D adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 211224..212249 Escherichia coli IAI39 7151660 YP_002406229.1 CDS fabZ NC_011750.1 212354 212809 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 212354..212809 Escherichia coli IAI39 7151968 YP_002406230.1 CDS lpxA NC_011750.1 212813 213601 D catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 212813..213601 Escherichia coli IAI39 7151271 YP_002406231.1 CDS lpxB NC_011750.1 213601 214749 D catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 213601..214749 Escherichia coli IAI39 7151965 YP_002406232.1 CDS rnhB NC_011750.1 214746 215342 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 214746..215342 Escherichia coli IAI39 7151966 YP_002406233.1 CDS dnaE NC_011750.1 215379 218861 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 215379..218861 Escherichia coli IAI39 7152659 YP_002406234.1 CDS accA NC_011750.1 218874 219833 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 218874..219833 Escherichia coli IAI39 7151156 YP_002406235.1 CDS ldcC NC_011750.1 219932 222073 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97480927, 98195734, 98357244, 9226257, 9723924; Product type e : enzyme; lysine decarboxylase 2 219932..222073 Escherichia coli IAI39 7150656 YP_002406236.1 CDS yaeR NC_011750.1 222130 222519 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 222130..222519 Escherichia coli IAI39 7151918 YP_002406237.1 CDS tilS NC_011750.1 222584 223882 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 222584..223882 Escherichia coli IAI39 7153223 YP_002406238.1 CDS ECIAI39_0192 NC_011750.1 223940 224662 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group complement(223940..224662) Escherichia coli IAI39 7152987 YP_002406239.1 CDS ECIAI39_0193 NC_011750.1 224767 225297 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 complement(224767..225297) Escherichia coli IAI39 7149521 YP_002406240.1 CDS gsk NC_011750.1 225394 226698 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90155203, 95238302, 2051480; Product type e : enzyme; inosine/guanosine kinase complement(225394..226698) Escherichia coli IAI39 7149522 YP_002406241.1 CDS aes NC_011750.1 226850 227809 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9401025, 98244813, 2051480, 7721718; Product type e : enzyme; acetyl esterase 226850..227809 Escherichia coli IAI39 7151593 YP_002406242.1 CDS hemH NC_011750.1 227806 228768 R protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase complement(227806..228768) Escherichia coli IAI39 7150696 YP_002406243.1 CDS adk NC_011750.1 228900 229544 R essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase complement(228900..229544) Escherichia coli IAI39 7151631 YP_002406244.1 CDS htpG NC_011750.1 229763 231637 R molecular chaperone; heat shock protein 90 complement(229763..231637) Escherichia coli IAI39 7150692 YP_002406245.1 CDS recR NC_011750.1 231747 232352 R involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR complement(231747..232352) Escherichia coli IAI39 7151686 YP_002406246.1 CDS ybaB NC_011750.1 232352 232681 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15322138, 1698765, 2674903; hypothetical protein complement(232352..232681) Escherichia coli IAI39 7152597 YP_002406247.1 CDS dnaX NC_011750.1 232734 234665 R catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau complement(232734..234665) Escherichia coli IAI39 7153283 YP_002406248.1 CDS apt NC_011750.1 234794 235345 R catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase complement(234794..235345) Escherichia coli IAI39 7151163 YP_002406249.1 CDS ybaN NC_011750.1 235498 235875 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(235498..235875) Escherichia coli IAI39 7150745 YP_002406250.1 CDS priC NC_011750.1 235945 236472 D PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' 235945..236472 Escherichia coli IAI39 7153287 YP_002406251.1 CDS ybaM NC_011750.1 236486 236647 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 236486..236647 Escherichia coli IAI39 7152477 YP_002406252.1 CDS kefA NC_011750.1 236859 240221 R small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA complement(236859..240221) Escherichia coli IAI39 7153286 YP_002406253.1 CDS acrR NC_011750.1 240349 240996 R regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR complement(240349..240996) Escherichia coli IAI39 7151892 YP_002406254.1 CDS acrA NC_011750.1 241138 242331 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15155734, 21450803, 383699, 390095, 94012493, 10920254, 7651136; Product type t : transporter; multidrug efflux system 241138..242331 Escherichia coli IAI39 7150679 YP_002406255.1 CDS ECIAI39_0210 NC_011750.1 245034 245924 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 complement(245034..245924) Escherichia coli IAI39 7150673 YP_002406256.1 CDS ECIAI39_0211 NC_011750.1 245921 246247 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 complement(245921..246247) Escherichia coli IAI39 7149523 YP_002406257.1 CDS ybaJ NC_011750.1 247361 247735 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1956303, 7984428, 14645275; hypothetical protein 247361..247735 Escherichia coli IAI39 7150674 YP_002406258.1 CDS hha NC_011750.1 247761 247979 D with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein 247761..247979 Escherichia coli IAI39 7153285 YP_002406259.1 CDS maa NC_011750.1 248151 248702 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82180540, 91310703, 9600841; Product type e : enzyme; maltose O-acetyltransferase 248151..248702 Escherichia coli IAI39 7151643 YP_002406260.1 CDS ylaC NC_011750.1 248818 249288 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 248818..249288 Escherichia coli IAI39 7151990 YP_002406261.1 CDS ylaB NC_011750.1 249452 251002 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 249452..251002 Escherichia coli IAI39 7154365 YP_002406262.1 CDS ybaA NC_011750.1 251043 251396 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(251043..251396) Escherichia coli IAI39 7154364 YP_002406263.1 CDS ybaZ NC_011750.1 251697 252086 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methylated DNA-protein cysteine alkyltransferase 251697..252086 Escherichia coli IAI39 7151311 YP_002406264.1 CDS ybaY NC_011750.1 252117 252689 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative lipoprotein complement(252117..252689) Escherichia coli IAI39 7153292 YP_002406265.1 CDS tesB NC_011750.1 252907 253767 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86139906, 91250410, 10876240; Product type e : enzyme; acyl-CoA thioesterase II 252907..253767 Escherichia coli IAI39 7153291 YP_002406266.1 CDS amtB NC_011750.1 253816 255102 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22020597, 9618533, 10931328, 1645722, 7984428; Product type t : transporter; ammonium transporter complement(253816..255102) Escherichia coli IAI39 7152963 YP_002406267.1 CDS glnK NC_011750.1 255132 255470 R indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 complement(255132..255470) Escherichia coli IAI39 7150734 YP_002406268.1 CDS mdlB NC_011750.1 255651 257432 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 94124004; Product type pt : putative transporter; putative multidrug transporter membrane\ATP-binding proteins complement(255651..257432) Escherichia coli IAI39 7151529 YP_002406269.1 CDS mdlA NC_011750.1 257425 259197 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 94124004, 10850996; Product type pt : putative transporter; putative multidrug transporter membrane\ATP-binding proteins complement(257425..259197) Escherichia coli IAI39 7152023 YP_002406270.1 CDS ybaO NC_011750.1 259227 259685 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7904973, 10850996; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(259227..259685) Escherichia coli IAI39 7152022 YP_002406271.1 CDS cof NC_011750.1 259838 260656 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217; Product type e : enzyme; thiamin pyrimidine pyrophosphate hydrolase complement(259838..260656) Escherichia coli IAI39 7153288 YP_002406272.1 CDS ybaE NC_011750.1 260756 262456 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 260756..262456 Escherichia coli IAI39 7150982 YP_002406273.1 CDS queC NC_011750.1 262521 263216 D YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC 262521..263216 Escherichia coli IAI39 7153284 YP_002406274.1 CDS ybaW NC_011750.1 263268 263666 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(263268..263666) Escherichia coli IAI39 7152561 YP_002406275.1 CDS ybaV NC_011750.1 263772 264143 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(263772..264143) Escherichia coli IAI39 7153290 YP_002406276.1 CDS ppiD NC_011750.1 264294 266165 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9670013; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase D complement(264294..266165) Escherichia coli IAI39 7153289 YP_002406277.1 CDS hupB NC_011750.1 266357 266629 R histone-like DNA-binding protein; transcriptional regulator HU subunit beta complement(266357..266629) Escherichia coli IAI39 7152463 YP_002406278.1 CDS lon NC_011750.1 266838 269192 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10094703, 14665623, 8939438, 91072263, 97137085, 2984174, 3042779, 3289547, 7988699, 8226758, 8294008; Product type e : enzyme; DNA-binding ATP-dependent protease La complement(266838..269192) Escherichia coli IAI39 7151692 YP_002406279.1 CDS clpX NC_011750.1 269380 270654 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(269380..270654) Escherichia coli IAI39 7152892 YP_002406280.1 CDS clpP NC_011750.1 270780 271403 R hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit complement(270780..271403) Escherichia coli IAI39 7150967 YP_002406281.1 CDS tig NC_011750.1 271649 272947 R Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor complement(271649..272947) Escherichia coli IAI39 7150965 YP_002406282.1 CDS bolA NC_011750.1 273291 273608 R positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA complement(273291..273608) Escherichia coli IAI39 7152986 YP_002406283.1 CDS yajG NC_011750.1 273913 274491 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 273913..274491 Escherichia coli IAI39 7150873 YP_002406284.1 CDS ampG NC_011750.1 274535 276010 D in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter 274535..276010 Escherichia coli IAI39 7153276 YP_002406285.1 CDS cyoA NC_011750.1 276470 277417 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92112945, 92371427, 9378722, 98021084, 11017202, 1322173, 2162835, 2162837, 2165491, 2168206, 8231804, 8618822; Product type c : carrier; cytochrome o ubiquinol oxidase subunit II 276470..277417 Escherichia coli IAI39 7150732 YP_002406286.1 CDS cyoB NC_011750.1 277439 279430 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 92345252, 93349845, 9378722, 98021084, 11017202, 2162835, 2168206; Product type c : carrier; cytochrome o ubiquinol oxidase subunit I 277439..279430 Escherichia coli IAI39 7151050 YP_002406287.1 CDS cyoC NC_011750.1 279420 280034 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 92345252, 93349845, 9378722, 98021084, 11017202, 2162835, 2168206; Product type c : carrier; cytochrome o ubiquinol oxidase subunit III 279420..280034 Escherichia coli IAI39 7151051 YP_002406288.1 CDS cyoD NC_011750.1 280034 280363 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 90366572, 92345252, 9378722, 98021084, 11017202, 2162835; Product type c : carrier; cytochrome o ubiquinol oxidase subunit IV 280034..280363 Escherichia coli IAI39 7151052 YP_002406289.1 CDS cyoE NC_011750.1 280375 281265 D converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 280375..281265 Escherichia coli IAI39 7151053 YP_002406290.1 CDS ECIAI39_0246 NC_011750.1 281384 281761 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 281384..281761 Escherichia coli IAI39 7151054 YP_002406291.1 CDS ECIAI39_0247 NC_011750.1 281745 282287 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase 281745..282287 Escherichia coli IAI39 7149525 YP_002406292.1 CDS ECIAI39_0248 NC_011750.1 282343 283338 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative zinc-dependent hydrolase complement(282343..283338) Escherichia coli IAI39 7149526 YP_002406293.1 CDS yajR NC_011750.1 283685 285049 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 283685..285049 Escherichia coli IAI39 7149527 YP_002406294.1 CDS yajQ NC_011750.1 285177 285668 R putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; putative nucleotide-binding protein complement(285177..285668) Escherichia coli IAI39 7153281 YP_002406295.1 CDS panE NC_011750.1 285836 286747 D ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 285836..286747 Escherichia coli IAI39 7153280 YP_002406296.1 CDS yajL NC_011750.1 286710 287300 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 97039868, 99173753, 99311269; DJ-1 family protein 286710..287300 Escherichia coli IAI39 7152326 YP_002406297.1 CDS thiI NC_011750.1 287354 288802 R Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI complement(287354..288802) Escherichia coli IAI39 7153278 YP_002406298.1 CDS xseB NC_011750.1 289008 289250 D catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 289008..289250 Escherichia coli IAI39 7152971 YP_002406299.1 CDS ispA NC_011750.1 289250 290149 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89291702, 91210228; Product type e : enzyme; geranyltranstransferase 289250..290149 Escherichia coli IAI39 7153183 YP_002406300.1 CDS dxs NC_011750.1 290174 292036 D catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 290174..292036 Escherichia coli IAI39 7151851 YP_002406301.1 CDS yajO NC_011750.1 292091 293065 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217, 16077126; Product type e : enzyme; aldoketo-oxidoreductase, NADP-binding 292091..293065 Escherichia coli IAI39 7151190 YP_002406302.1 CDS pgpA NC_011750.1 293119 293637 R hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A complement(293119..293637) Escherichia coli IAI39 7153279 YP_002406303.1 CDS thiL NC_011750.1 293615 294592 R catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase complement(293615..294592) Escherichia coli IAI39 7152385 YP_002406304.1 CDS nusB NC_011750.1 294670 295089 R Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB complement(294670..295089) Escherichia coli IAI39 7152972 YP_002406305.1 CDS ribH NC_011750.1 295109 295579 R RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase complement(295109..295579) Escherichia coli IAI39 7152285 YP_002406306.1 CDS ribD NC_011750.1 295668 296771 R riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase complement(295668..296771) Escherichia coli IAI39 7152629 YP_002406307.1 CDS nrdR NC_011750.1 296775 297224 R Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator NrdR complement(296775..297224) Escherichia coli IAI39 7152628 YP_002406308.1 CDS ECIAI39_0264 NC_011750.1 297315 297563 D Evidence 6 : Doubtful CDS; hypothetical protein 297315..297563 Escherichia coli IAI39 7152252 YP_002406309.1 CDS ydcM NC_011750.1 297548 298756 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase complement(297548..298756) Escherichia coli IAI39 7149528 YP_002406310.1 CDS ECIAI39_0266 NC_011750.1 298772 299050 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF A (fragment), IS609 298772..299050 Escherichia coli IAI39 7153527 YP_002406311.1 CDS tsx NC_011750.1 299960 300844 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91092502, 91358319, 93352541; Product type m : membrane component; nucleoside channel phage T6/colicin K receptor 299960..300844 Escherichia coli IAI39 7153277 YP_002406312.1 CDS yajD NC_011750.1 300882 301229 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(300882..301229) Escherichia coli IAI39 7153049 YP_002406313.1 CDS ECIAI39_0270 NC_011750.1 301317 301631 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative toxin antitoxin plasmid stabilization system protein complement(301317..301631) Escherichia coli IAI39 7153275 YP_002406314.1 CDS ECIAI39_0271 NC_011750.1 301591 301833 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative toxin antitoxin plasmid stabilisation system containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain complement(301591..301833) Escherichia coli IAI39 7149530 YP_002406315.1 CDS secF NC_011750.1 301985 302956 R forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF complement(301985..302956) Escherichia coli IAI39 7149531 YP_002406316.1 CDS secD NC_011750.1 302967 304814 R part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD complement(302967..304814) Escherichia coli IAI39 7152822 YP_002406317.1 CDS yajC NC_011750.1 304842 305174 R member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC complement(304842..305174) Escherichia coli IAI39 7152820 YP_002406318.1 CDS tgt NC_011750.1 305197 306324 R Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase complement(305197..306324) Escherichia coli IAI39 7153274 YP_002406319.1 CDS queA NC_011750.1 306379 307449 R Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase complement(306379..307449) Escherichia coli IAI39 7152964 YP_002406320.1 CDS acpH NC_011750.1 307542 308123 D Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; acyl carrier protein phosphodiesterase 307542..308123 Escherichia coli IAI39 7152560 YP_002406321.1 CDS ECIAI39_0278 NC_011750.1 308144 309589 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(308144..309589) Escherichia coli IAI39 7150668 YP_002406322.1 CDS malZ NC_011750.1 309775 311592 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92184757, 1706703, 1918057; Product type e : enzyme; maltodextrin glucosidase complement(309775..311592) Escherichia coli IAI39 7149532 YP_002406323.1 CDS proY NC_011750.1 311748 313121 R cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; putative proline-specific permease complement(311748..313121) Escherichia coli IAI39 7152007 YP_002406324.1 CDS brnQ NC_011750.1 313197 314516 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3078876, 6998958, 3550103, 7984428; Product type t : transporter; branched chain amino acid transporter complement(313197..314516) Escherichia coli IAI39 7152492 YP_002406325.1 CDS phoR NC_011750.1 314923 316218 R membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein complement(314923..316218) Escherichia coli IAI39 7150875 YP_002406326.1 CDS phoB NC_011750.1 316276 316965 R two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB complement(316276..316965) Escherichia coli IAI39 7152415 YP_002406327.1 CDS sbcD NC_011750.1 317155 318357 D with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease subunit SbcD 317155..318357 Escherichia coli IAI39 7152410 YP_002406328.1 CDS sbcC NC_011750.1 318354 321497 D with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease subunit SbcC 318354..321497 Escherichia coli IAI39 7152806 YP_002406329.1 CDS araJ NC_011750.1 321623 322807 D member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ 321623..322807 Escherichia coli IAI39 7152805 YP_002406330.1 CDS mak NC_011750.1 322947 323855 R catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase complement(322947..323855) Escherichia coli IAI39 7150755 YP_002406331.1 CDS rdgC NC_011750.1 323980 324891 D Required for efficient pilin antigenic variation; recombination associated protein 323980..324891 Escherichia coli IAI39 7151994 YP_002406332.1 CDS ykiA NC_011750.1 325049 325327 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(325049..325327) Escherichia coli IAI39 7152582 YP_002406333.1 CDS yaiE NC_011750.1 325535 325819 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(325535..325819) Escherichia coli IAI39 7154363 YP_002406334.1 CDS aroM NC_011750.1 325891 326568 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 86085675, 3001025; hypothetical protein complement(325891..326568) Escherichia coli IAI39 7153259 YP_002406335.1 CDS yaiA NC_011750.1 326826 327017 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(326826..327017) Escherichia coli IAI39 7150785 YP_002406336.1 CDS aroL NC_011750.1 327067 327591 R type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase II complement(327067..327591) Escherichia coli IAI39 7153256 YP_002406337.1 CDS yaiI NC_011750.1 327774 328232 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(327774..328232) Escherichia coli IAI39 7150784 YP_002406338.1 CDS proC NC_011750.1 328352 329161 D catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 328352..329161 Escherichia coli IAI39 7153260 YP_002406339.1 CDS adrA NC_011750.1 329178 330293 R catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA complement(329178..330293) Escherichia coli IAI39 7152485 YP_002406340.1 CDS psiF NC_011750.1 330395 330715 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3533724, 2160940; Product type f : factor; hypothetical protein complement(330395..330715) Escherichia coli IAI39 7153258 YP_002406341.1 CDS phoA NC_011750.1 330834 332249 R Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme; alkaline phosphatase complement(330834..332249) Escherichia coli IAI39 7152501 YP_002406342.1 CDS yaiB NC_011750.1 332349 332609 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(332349..332609) Escherichia coli IAI39 7152409 YP_002406343.1 CDS ECIAI39_0300 NC_011750.1 332791 332994 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(332791..332994) Escherichia coli IAI39 7153257 YP_002406344.1 CDS ddl NC_011750.1 333072 334166 D D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 333072..334166 Escherichia coli IAI39 7149533 YP_002406345.1 CDS yaiZ NC_011750.1 334190 334534 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(334190..334534) Escherichia coli IAI39 7151102 YP_002406346.1 CDS yaiY NC_011750.1 334662 334970 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 334662..334970 Escherichia coli IAI39 7153273 YP_002406347.1 CDS yaiW NC_011750.1 335028 336122 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative lipoprotein complement(335028..336122) Escherichia coli IAI39 7153272 YP_002406348.1 CDS sbmA NC_011750.1 336135 337355 R in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transport protein complement(336135..337355) Escherichia coli IAI39 7153269 YP_002406349.1 CDS ECIAI39_0306 NC_011750.1 337375 337569 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(337375..337569) Escherichia coli IAI39 7152807 YP_002406350.1 CDS ampH NC_011750.1 337707 338864 D this protein has no known enzymatic function; beta-lactam binding protein AmpH 337707..338864 Escherichia coli IAI39 7149534 YP_002406351.1 CDS yaiV NC_011750.1 338865 339533 R Evidence 4 : Homologs of previously reported genes of unknown function; putative DNA-binding transcriptional regulator complement(338865..339533) Escherichia coli IAI39 7150733 YP_002406352.1 CDS ECIAI39_0309 NC_011750.1 339574 342483 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative flagellin-like structural protein complement(339574..342483) Escherichia coli IAI39 7153268 YP_002406353.1 CDS hemB NC_011750.1 343009 343983 D catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 343009..343983 Escherichia coli IAI39 7149535 YP_002406354.1 CDS ECIAI39_0311 NC_011750.1 344142 344468 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 344142..344468 Escherichia coli IAI39 7151625 YP_002406355.1 CDS ECIAI39_0312 NC_011750.1 344465 345355 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 344465..345355 Escherichia coli IAI39 7149536 YP_002406356.1 CDS tauD NC_011750.1 345237 346364 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; taurine dioxygenase, 2-oxoglutarate-dependent complement(345237..346364) Escherichia coli IAI39 7149537 YP_002406357.1 CDS tauB NC_011750.1 346916 347683 R Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding subunit complement(346916..347683) Escherichia coli IAI39 7152950 YP_002406358.1 CDS tauA NC_011750.1 347696 348658 R with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit complement(347696..348658) Escherichia coli IAI39 7152949 YP_002406359.1 CDS yaiS NC_011750.1 349267 349938 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 349267..349938 Escherichia coli IAI39 7152948 YP_002406360.1 CDS yaiP NC_011750.1 349948 351144 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated glycosyltransferase 349948..351144 Escherichia coli IAI39 7153266 YP_002406361.1 CDS yaiX NC_011750.1 351122 351703 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transferase 351122..351703 Escherichia coli IAI39 7153264 YP_002406362.1 CDS yaiO NC_011750.1 351705 352478 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 351705..352478 Escherichia coli IAI39 7153270 YP_002406363.1 CDS frmR NC_011750.1 352663 352938 D formaldehyde-induced negative regulator of the frmRAB operon; regulator protein FrmR 352663..352938 Escherichia coli IAI39 7153262 YP_002406364.1 CDS frmA NC_011750.1 352973 354082 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15466022, 87172301, 1731906; Product type e : enzyme; alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase 352973..354082 Escherichia coli IAI39 7151416 YP_002406365.1 CDS frmB NC_011750.1 354174 355007 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16567800, 15466022; Product type e : enzyme; S-formylglutathione hydrolase 354174..355007 Escherichia coli IAI39 7151413 YP_002406366.1 CDS yaiL NC_011750.1 355133 355672 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15115803, 12878731, 13129938; Product type e : enzyme; nucleoprotein/polynucleotide-associated enzyme complement(355133..355672) Escherichia coli IAI39 7151414 YP_002406367.1 CDS mhpT NC_011750.1 355774 356928 R Evidence 2b : Function of strongly homologous gene; PubMedId : 7961399; Product type t : transporter; putative 3-hydroxyphenylpropionic transporter MhpT complement(355774..356928) Escherichia coli IAI39 7153261 YP_002406368.1 CDS mhpE NC_011750.1 357164 358177 R catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase complement(357164..358177) Escherichia coli IAI39 7152077 YP_002406369.1 CDS mhpF NC_011750.1 358174 359124 R catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase complement(358174..359124) Escherichia coli IAI39 7152074 YP_002406370.1 CDS mhpD NC_011750.1 359121 359930 R catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid; 2-keto-4-pentenoate hydratase complement(359121..359930) Escherichia coli IAI39 7152075 YP_002406371.1 CDS mhpC NC_011750.1 359940 360821 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87008429, 94002258, 15663942; Product type e : enzyme; 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase complement(359940..360821) Escherichia coli IAI39 7152073 YP_002406372.1 CDS mhpB NC_011750.1 360824 361768 R catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family; 3-(2,3-dihydroxyphenyl)propionate dioxygenase complement(360824..361768) Escherichia coli IAI39 7152072 YP_002406373.1 CDS mhpA NC_011750.1 361770 363434 R catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase complement(361770..363434) Escherichia coli IAI39 7152071 YP_002406374.1 CDS mhpR NC_011750.1 363613 364458 D activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional activator MhpR 363613..364458 Escherichia coli IAI39 7152070 YP_002406375.1 CDS lacI NC_011750.1 364535 365617 D transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor 364535..365617 Escherichia coli IAI39 7152076 YP_002406376.1 CDS lacZ NC_011750.1 365740 368814 D forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon; beta-D-galactosidase 365740..368814 Escherichia coli IAI39 7151913 YP_002406377.1 CDS lacY NC_011750.1 368866 370119 D lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease 368866..370119 Escherichia coli IAI39 7151915 YP_002406378.1 CDS lacA NC_011750.1 370185 370796 D transfers acetyl group from acetyl-CoA to the 6-hydroxyl of galactopyranosides; exact physiological role is unknown; galactoside O-acetyltransferase 370185..370796 Escherichia coli IAI39 7151914 YP_002406379.1 CDS cynX NC_011750.1 370884 372038 R MFS transporter family member induced in the presence of cyanate as part of a 3 gene operon; not essential; putative cyanate transporter complement(370884..372038) Escherichia coli IAI39 7151912 YP_002406380.1 CDS cynS NC_011750.1 372071 372541 R catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide; cyanate hydratase complement(372071..372541) Escherichia coli IAI39 7151049 YP_002406381.1 CDS cynT NC_011750.1 372572 373231 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91242169, 92156106, 94075239, 3049588; Product type e : enzyme; carbonic anhydrase complement(372572..373231) Escherichia coli IAI39 7151047 YP_002406382.1 CDS cynR NC_011750.1 373341 374240 D controls the expression of the cynTSX operon involved in degrading and using cyanate as a sole nitrogen source; DNA-binding transcriptional regulator CynR 373341..374240 Escherichia coli IAI39 7151048 YP_002406383.1 CDS ECIAI39_0341 NC_011750.1 374364 374894 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 374364..374894 Escherichia coli IAI39 7151046 YP_002406384.1 CDS ECIAI39_0342 NC_011750.1 374999 375721 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 374999..375721 Escherichia coli IAI39 7149538 YP_002406385.1 CDS codA NC_011750.1 375809 377092 R Catalyzes the deamination of cytosine to uracil and ammonia; cytosine deaminase complement(375809..377092) Escherichia coli IAI39 7149539 YP_002406386.1 CDS codB NC_011750.1 377082 378341 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92349961; Product type t : transporter; cytosine permease complement(377082..378341) Escherichia coli IAI39 7150980 YP_002406387.1 CDS prpE NC_011750.1 378579 380465 R catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; propionyl-CoA synthetase complement(378579..380465) Escherichia coli IAI39 7150981 YP_002406388.1 CDS prpD NC_011750.1 380505 381956 R functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C; 2-methylcitrate dehydratase complement(380505..381956) Escherichia coli IAI39 7152496 YP_002406389.1 CDS prpC NC_011750.1 381990 383159 R catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase complement(381990..383159) Escherichia coli IAI39 7152495 YP_002406390.1 CDS prpB NC_011750.1 383319 384209 R catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase complement(383319..384209) Escherichia coli IAI39 7152494 YP_002406391.1 CDS prpR NC_011750.1 384448 386034 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9325432, 15805526; Product type r : regulator; DNA-binding transcriptional activator 384448..386034 Escherichia coli IAI39 7152493 YP_002406392.1 CDS yahO NC_011750.1 386132 386407 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(386132..386407) Escherichia coli IAI39 7152497 YP_002406393.1 CDS yahN NC_011750.1 386554 387225 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12879215; Product type t : transporter; neutral amino-acid efflux system 386554..387225 Escherichia coli IAI39 7153255 YP_002406394.1 CDS yahM NC_011750.1 387250 387486 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(387250..387486) Escherichia coli IAI39 7153254 YP_002406395.1 CDS yahL NC_011750.1 387900 388715 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(387900..388715) Escherichia coli IAI39 7150637 YP_002406396.1 CDS ECIAI39_0357 NC_011750.1 390093 391079 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; sugar ABC transporter permease complement(390093..391079) Escherichia coli IAI39 7153251 YP_002406397.1 CDS ECIAI39_0358 NC_011750.1 391046 392032 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; sugar ABC transporter permease complement(391046..392032) Escherichia coli IAI39 7149540 YP_002406398.1 CDS ECIAI39_0359 NC_011750.1 392010 393509 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-binding protein of ABC sugar transport system complement(392010..393509) Escherichia coli IAI39 7149541 YP_002406399.1 CDS ECIAI39_0360 NC_011750.1 393543 394529 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; ribose ABC transporter substrate-binding protein complement(393543..394529) Escherichia coli IAI39 7149542 YP_002406400.1 CDS ECIAI39_0361 NC_011750.1 394627 394704 R hypothetical protein complement(394627..394704) Escherichia coli IAI39 7149543 YP_002406401.1 CDS ECIAI39_0362 NC_011750.1 394780 395220 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(394780..395220) Escherichia coli IAI39 7149544 YP_002406402.1 CDS yahJ NC_011750.1 395488 396870 R metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain; putative deaminase complement(395488..396870) Escherichia coli IAI39 7149545 YP_002406403.1 CDS yahI NC_011750.1 396880 397830 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7711027, 11523892; Product type pe : putative enzyme; putative carbamate kinase complement(396880..397830) Escherichia coli IAI39 7153249 YP_002406404.1 CDS yahG NC_011750.1 397925 399343 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(397925..399343) Escherichia coli IAI39 7153248 YP_002406405.1 CDS yahF NC_011750.1 399343 400890 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative enzyme with acyl-CoA domain complement(399343..400890) Escherichia coli IAI39 7153247 YP_002406406.1 CDS yahE NC_011750.1 400880 401743 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(400880..401743) Escherichia coli IAI39 7153246 YP_002406407.1 CDS yahD NC_011750.1 401783 402388 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(401783..402388) Escherichia coli IAI39 7153245 YP_002406408.1 CDS yahC NC_011750.1 402646 403143 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 402646..403143 Escherichia coli IAI39 7153244 YP_002406409.1 CDS yahB NC_011750.1 403235 404167 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 403235..404167 Escherichia coli IAI39 7153243 YP_002406410.1 CDS yahA NC_011750.1 404209 405297 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15995192; Product type e : enzyme; cyclic di-GMP phosphodiesterase complement(404209..405297) Escherichia coli IAI39 7153242 YP_002406411.1 CDS betT NC_011750.1 406168 408201 R proton-motive-force-driven choline transporter; choline transport protein BetT complement(406168..408201) Escherichia coli IAI39 7153241 YP_002406412.1 CDS betI NC_011750.1 408330 408917 D HTH-type; bet1; Repressor involved in choline regulation of the bet genes; transcriptional regulator BetI 408330..408917 Escherichia coli IAI39 7150855 YP_002406413.1 CDS betB NC_011750.1 408931 410403 D catalyzes the formation of betaine from betaine aldehyde; betaine aldehyde dehydrogenase 408931..410403 Escherichia coli IAI39 7150854 YP_002406414.1 CDS betA NC_011750.1 410372 412105 D catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase 410372..412105 Escherichia coli IAI39 7150853 YP_002406415.1 CDS ECIAI39_0376 NC_011750.1 412299 412799 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 412299..412799 Escherichia coli IAI39 7150852 YP_002406416.1 CDS ykgG NC_011750.1 413042 413737 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(413042..413737) Escherichia coli IAI39 7149546 YP_002406417.1 CDS ykgF NC_011750.1 413730 415157 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(413730..415157) Escherichia coli IAI39 7154359 YP_002406418.1 CDS ykgE NC_011750.1 415168 415887 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydroxyacid oxidoreductase (Fe-S centre) complement(415168..415887) Escherichia coli IAI39 7154358 YP_002406419.1 CDS ykgD NC_011750.1 416415 417269 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative AraC-type DNA-binding transcriptional regulator complement(416415..417269) Escherichia coli IAI39 7154357 YP_002406420.1 CDS ykgC NC_011750.1 417496 418821 D Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 417496..418821 Escherichia coli IAI39 7154356 YP_002406421.1 CDS ykgI NC_011750.1 418930 419166 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 418930..419166 Escherichia coli IAI39 7154355 YP_002406422.1 CDS ykgB NC_011750.1 419178 419771 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 419178..419771 Escherichia coli IAI39 7154360 YP_002406423.1 CDS ECIAI39_0384 NC_011750.1 419931 420815 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative reductase complement(419931..420815) Escherichia coli IAI39 7154354 YP_002406424.1 CDS ykgA NC_011750.1 421015 421905 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator ykgA 421015..421905 Escherichia coli IAI39 7149547 YP_002406425.1 CDS ECIAI39_0388 NC_011750.1 426844 427695 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17575004; Product type pe : putative enzyme; putative aldo-keto reductase 426844..427695 Escherichia coli IAI39 7151193 YP_002406426.1 CDS ECIAI39_0389 NC_011750.1 427722 428711 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldo-keto reductase 427722..428711 Escherichia coli IAI39 7149548 YP_002406427.1 CDS ECIAI39_0390 NC_011750.1 428742 429716 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator, lysR family complement(428742..429716) Escherichia coli IAI39 7149549 YP_002406428.1 CDS ECIAI39_0391 NC_011750.1 429841 430860 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative LysR-like transcriptional regulator complement(429841..430860) Escherichia coli IAI39 7149550 YP_002406429.1 CDS ECIAI39_0392 NC_011750.1 430924 431844 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 430924..431844 Escherichia coli IAI39 7149551 YP_002406430.1 CDS ECIAI39_0393 NC_011750.1 432089 433231 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NADH-dependent flavin oxidoreductase 432089..433231 Escherichia coli IAI39 7149552 YP_002406431.1 CDS rpmE2 NC_011750.1 434171 434434 D RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B 434171..434434 Escherichia coli IAI39 7149553 YP_002406432.1 CDS rpmJ NC_011750.1 434434 434574 D smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 434434..434574 Escherichia coli IAI39 7154362 YP_002406433.1 CDS insA NC_011750.1 435268 435543 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 435268..435543 Escherichia coli IAI39 7149554 YP_002406434.1 CDS insB NC_011750.1 435462 435965 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 435462..435965 Escherichia coli IAI39 7151780 YP_002406435.1 CDS ykgK NC_011750.1 436058 436648 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 436058..436648 Escherichia coli IAI39 7151791 YP_002406436.1 CDS yagY NC_011750.1 437367 438035 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 437367..438035 Escherichia coli IAI39 7151200 YP_002406437.1 CDS yagX NC_011750.1 438061 440586 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 438061..440586 Escherichia coli IAI39 7153240 YP_002406438.1 CDS yagW NC_011750.1 440576 442219 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative surface or exported protein 440576..442219 Escherichia coli IAI39 7153239 YP_002406439.1 CDS yagV NC_011750.1 442188 442898 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 442188..442898 Escherichia coli IAI39 7153238 YP_002406440.1 CDS yagU NC_011750.1 443789 444403 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(443789..444403) Escherichia coli IAI39 7153237 YP_002406441.1 CDS ECIAI39_0407 NC_011750.1 444618 444791 R Evidence 6 : Doubtful CDS; hypothetical protein complement(444618..444791) Escherichia coli IAI39 7153236 YP_002406442.1 CDS proA NC_011750.1 445191 446444 R Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase complement(445191..446444) Escherichia coli IAI39 7150636 YP_002406443.1 CDS proB NC_011750.1 446456 447559 R catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase complement(446456..447559) Escherichia coli IAI39 7152483 YP_002406444.1 CDS phoE NC_011750.1 447848 448903 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89178658, 89380253, 92219258, 98090453, 1380671, 1848301, 1848682, 6089111, 6341601, 7679770; Product type t : transporter; outer membrane phosphoporin protein E 447848..448903 Escherichia coli IAI39 7152484 YP_002406445.1 CDS crl NC_011750.1 448942 449343 R involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl complement(448942..449343) Escherichia coli IAI39 7152411 YP_002406446.1 CDS frsA NC_011750.1 449401 450645 R forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein complement(449401..450645) Escherichia coli IAI39 7150998 YP_002406447.1 CDS gpt NC_011750.1 450737 451195 R catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase complement(450737..451195) Escherichia coli IAI39 7151418 YP_002406448.1 CDS pepD NC_011750.1 451456 452913 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1695895, 21101837, 88121730, 92204123, 2651887; Product type e : enzyme; aminoacyl-histidine dipeptidase 451456..452913 Escherichia coli IAI39 7151582 YP_002406449.1 CDS prfH NC_011750.1 452970 453470 R similar to release factor 1 and 2; peptide chain release factor-like protein complement(452970..453470) Escherichia coli IAI39 7152363 YP_002406450.1 CDS ECIAI39_0416 NC_011750.1 453581 454732 R mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY; hypothetical protein complement(453581..454732) Escherichia coli IAI39 7152475 YP_002406451.1 CDS yafP NC_011750.1 454911 455363 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12813093; Product type pe : putative enzyme; hypothetical protein complement(454911..455363) Escherichia coli IAI39 7149556 YP_002406452.1 CDS dinB NC_011750.1 455360 456415 R involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV complement(455360..456415) Escherichia coli IAI39 7153232 YP_002406453.1 CDS mbhA NC_011750.1 456486 457271 R Evidence 2b : Function of strongly homologous gene; PubMedId : 15687208; Product type s : structure; hypothetical protein complement(456486..457271) Escherichia coli IAI39 7151137 YP_002406454.1 CDS fhiA NC_011750.1 457216 458901 D Evidence 7 : Gene remnant; Product type s : structure; flagellar system protein 457216..458901 Escherichia coli IAI39 7152019 YP_002406455.1 CDS yafM NC_011750.1 459067 459564 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(459067..459564) Escherichia coli IAI39 7151312 YP_002406456.1 CDS yafL NC_011750.1 459740 460489 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported hydrolase complement(459740..460489) Escherichia coli IAI39 7153231 YP_002406457.1 CDS dinJ NC_011750.1 460699 460959 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99451883; Product type pf : putative factor; antitoxin of YafQ-DinJ toxin-antitoxin system 460699..460959 Escherichia coli IAI39 7153230 YP_002406458.1 CDS yafQ NC_011750.1 460962 461210 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15009896; Product type f : factor; toxin of the YafQ-DinJ toxin-antitoxin system 460962..461210 Escherichia coli IAI39 7151142 YP_002406459.1 CDS insM NC_011750.1 461272 461574 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS600 461272..461574 Escherichia coli IAI39 7153233 YP_002406460.1 CDS ECIAI39_0427 NC_011750.1 461610 462428 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 461610..462428 Escherichia coli IAI39 7151823 YP_002406461.1 CDS yafK NC_011750.1 462663 463403 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 462663..463403 Escherichia coli IAI39 7149557 YP_002406462.1 CDS yafJ NC_011750.1 463374 464141 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutamine amidotransferases class-II complement(463374..464141) Escherichia coli IAI39 7153229 YP_002406463.1 CDS gmhA NC_011750.1 464246 464824 R catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase complement(464246..464824) Escherichia coli IAI39 7153228 YP_002406464.1 CDS fadE NC_011750.1 465064 467508 D functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase 465064..467508 Escherichia coli IAI39 7151956 YP_002406465.1 CDS ivy NC_011750.1 467551 468024 R inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor complement(467551..468024) Escherichia coli IAI39 7151275 YP_002406466.1 CDS yafV NC_011750.1 468178 468948 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8526497; Product type pe : putative enzyme; hypothetical protein 468178..468948 Escherichia coli IAI39 7151868 YP_002406467.1 CDS dnaQ NC_011750.1 469256 469987 R 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon complement(469256..469987) Escherichia coli IAI39 7150635 YP_002406468.1 CDS rnhA NC_011750.1 470052 470519 D An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 470052..470519 Escherichia coli IAI39 7151161 YP_002406469.1 CDS yafS NC_011750.1 470516 471238 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase complement(470516..471238) Escherichia coli IAI39 7152658 YP_002406470.1 CDS gloB NC_011750.1 471272 472027 D catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase 471272..472027 Escherichia coli IAI39 7153234 YP_002406471.1 CDS mltD NC_011750.1 472099 473457 D catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D 472099..473457 Escherichia coli IAI39 7151535 YP_002406472.1 CDS yafE NC_011750.1 473506 474276 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase complement(473506..474276) Escherichia coli IAI39 7152092 YP_002406473.1 CDS yafD NC_011750.1 474353 475153 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1663890; hypothetical protein complement(474353..475153) Escherichia coli IAI39 7153227 YP_002406474.1 CDS yafC NC_011750.1 475394 476308 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 475394..476308 Escherichia coli IAI39 7153226 YP_002406475.1 CDS dkgB NC_011750.1 476305 477108 R catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B complement(476305..477108) Escherichia coli IAI39 7153225 YP_002406476.1 CDS gmhB NC_011750.1 482861 483433 R Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase complement(482861..483433) Escherichia coli IAI39 7149778 YP_002406477.1 CDS metN NC_011750.1 483621 484652 D part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit 483621..484652 Escherichia coli IAI39 7151563 YP_002406478.1 CDS metI NC_011750.1 484645 485298 D part of the MetNIQ methionine uptake system; DL-methionine transporter permease subunit 484645..485298 Escherichia coli IAI39 7152061 YP_002406479.1 CDS metQ NC_011750.1 485338 486153 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12169620, 12218041, 12819857, 1459951; Product type t : transporter; DL-methionine transporter substrate-binding subunit 485338..486153 Escherichia coli IAI39 7152057 YP_002406480.1 CDS rcsF NC_011750.1 486271 486675 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 93094132; Product type pr : putative regulator; outer membrane lipoprotein 486271..486675 Escherichia coli IAI39 7152062 YP_002406481.1 CDS yaeB NC_011750.1 486672 487379 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 486672..487379 Escherichia coli IAI39 7152581 YP_002406482.1 CDS proS NC_011750.1 487490 489208 D catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 487490..489208 Escherichia coli IAI39 7153216 YP_002406483.1 CDS ECIAI39_0450 NC_011750.1 489304 489744 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 complement(489304..489744) Escherichia coli IAI39 7152488 YP_002406484.1 CDS ECIAI39_0451 NC_011750.1 489873 491396 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9353259, 10413481; Product type e : enzyme; Group II intron-encoded reverse transcriptase/maturase complement(489873..491396) Escherichia coli IAI39 7150519 YP_002406485.1 CDS ECIAI39_0453 NC_011750.1 492440 492787 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS3 family complement(492440..492787) Escherichia coli IAI39 7149560 YP_002406486.1 CDS yaeF NC_011750.1 492798 493616 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 492798..493616 Escherichia coli IAI39 7149561 YP_002406487.1 CDS nlpE NC_011750.1 493646 494356 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11830644, 95362641, 95362642; Product type lp : lipoprotein; lipoprotein involved with copper homeostasis and adhesion complement(493646..494356) Escherichia coli IAI39 7153217 YP_002406488.1 CDS yaeJ NC_011750.1 494370 494792 R Evidence 4 : Homologs of previously reported genes of unknown function; peptidyl-tRNA hydrolase domain-containing protein complement(494370..494792) Escherichia coli IAI39 7152237 YP_002406489.1 CDS yaeQ NC_011750.1 494789 495334 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(494789..495334) Escherichia coli IAI39 7153219 YP_002406490.1 CDS yaeP NC_011750.1 495500 495700 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 495500..495700 Escherichia coli IAI39 7153222 YP_002406491.1 CDS rof NC_011750.1 495693 495947 D Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator 495693..495947 Escherichia coli IAI39 7153221 YP_002406492.1 CDS ECIAI39_0460 NC_011750.1 496017 496547 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 496017..496547 Escherichia coli IAI39 7152665 YP_002406493.1 CDS ECIAI39_0461 NC_011750.1 496652 497374 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 496652..497374 Escherichia coli IAI39 7149562 YP_002406494.1 CDS ybbM NC_011750.1 497539 498318 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative permease of an ABC transporter complement(497539..498318) Escherichia coli IAI39 7149563 YP_002406495.1 CDS ybbL NC_011750.1 498305 498982 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein YbbL complement(498305..498982) Escherichia coli IAI39 7153296 YP_002406496.1 CDS ybbK NC_011750.1 499128 500045 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative protease, membrane anchored 499128..500045 Escherichia coli IAI39 7153295 YP_002406497.1 CDS ybbJ NC_011750.1 500045 500500 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 500045..500500 Escherichia coli IAI39 7153294 YP_002406498.1 CDS ECIAI39_0466 NC_011750.1 500603 500965 R hypothetical protein complement(500603..500965) Escherichia coli IAI39 7153293 YP_002406499.1 CDS ECIAI39_0467 NC_011750.1 501331 502347 D hypothetical protein 501331..502347 Escherichia coli IAI39 7149564 YP_002406500.1 CDS ECIAI39_0468 NC_011750.1 502401 502823 D putative lipoprotein 502401..502823 Escherichia coli IAI39 7149565 YP_002406501.1 CDS ECIAI39_0469 NC_011750.1 502820 503023 D hypothetical protein 502820..503023 Escherichia coli IAI39 7149566 YP_002406502.1 CDS insG NC_011750.1 503142 504470 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element 503142..504470 Escherichia coli IAI39 7149567 YP_002406503.1 CDS cueR NC_011750.1 504459 504872 R activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR complement(504459..504872) Escherichia coli IAI39 7151808 YP_002406504.1 CDS insB NC_011750.1 505033 505536 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' complement(505033..505536) Escherichia coli IAI39 7152852 YP_002406505.1 CDS insA NC_011750.1 505455 505730 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA complement(505455..505730) Escherichia coli IAI39 7151792 YP_002406506.1 CDS allB NC_011750.1 505611 507029 D Plays a crucial role on both purine and pyrimidine metabolism; allantoinase 505611..507029 Escherichia coli IAI39 7151781 YP_002406507.1 CDS ybbY NC_011750.1 507086 508387 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative purine permease YbbY 507086..508387 Escherichia coli IAI39 7150715 YP_002406508.1 CDS glxK NC_011750.1 508409 509554 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20069628; Product type e : enzyme; glycerate kinase II 508409..509554 Escherichia coli IAI39 7153297 YP_002406509.1 CDS ylbA NC_011750.1 509684 510469 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(509684..510469) Escherichia coli IAI39 7151558 YP_002406510.1 CDS allC NC_011750.1 510480 511715 R allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase complement(510480..511715) Escherichia coli IAI39 7154366 YP_002406511.1 CDS allD NC_011750.1 511737 512786 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12460564, 20069628, 69151449; Product type e : enzyme; ureidoglycolate dehydrogenase complement(511737..512786) Escherichia coli IAI39 7150716 YP_002406512.1 CDS fdrA NC_011750.1 513104 514771 D multicopy suppressor of dominant negative ftsH mutations; membrane protein FdrA 513104..514771 Escherichia coli IAI39 7150717 YP_002406513.1 CDS ylbE NC_011750.1 514781 516040 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 514781..516040 Escherichia coli IAI39 7151292 YP_002406514.1 CDS ylbF NC_011750.1 516051 516866 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 516051..516866 Escherichia coli IAI39 7154367 YP_002406515.1 CDS ybcF NC_011750.1 516863 517756 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2464576, 2644189, 7920643, 7940673, 7984428; Product type pe : putative enzyme; carbamate kinase 516863..517756 Escherichia coli IAI39 7154368 YP_002406516.1 CDS purK NC_011750.1 517989 519056 R With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit complement(517989..519056) Escherichia coli IAI39 7153298 YP_002406517.1 CDS purE NC_011750.1 519053 519562 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10074353, 8117684, 89123018, 89123019, 92287929, 10574791; Product type e : enzyme; N5-carboxyaminoimidazole ribonucleotide mutase complement(519053..519562) Escherichia coli IAI39 7152530 YP_002406518.1 CDS lpxH NC_011750.1 519680 520402 R catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase complement(519680..520402) Escherichia coli IAI39 7152527 YP_002406519.1 CDS ppiB NC_011750.1 520405 520899 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90272647, 91175755, 1606970, 1864365, 8601841, 9298646, 9600841; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase B complement(520405..520899) Escherichia coli IAI39 7151969 YP_002406520.1 CDS ECIAI39_0489 NC_011750.1 521128 521454 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 521128..521454 Escherichia coli IAI39 7152461 YP_002406521.1 CDS ECIAI39_0490 NC_011750.1 521451 522341 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 521451..522341 Escherichia coli IAI39 7149568 YP_002406522.1 CDS cysS NC_011750.1 522384 523769 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 522384..523769 Escherichia coli IAI39 7149569 YP_002406523.1 CDS ybcI NC_011750.1 523805 524326 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(523805..524326) Escherichia coli IAI39 7151069 YP_002406524.1 CDS ybcJ NC_011750.1 524434 524646 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12837795, 1748668, 7567469; Product type pr : putative regulator; hypothetical protein complement(524434..524646) Escherichia coli IAI39 7153300 YP_002406525.1 CDS folD NC_011750.1 524648 525514 R catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(524648..525514) Escherichia coli IAI39 7153301 YP_002406526.1 CDS sfmA NC_011750.1 525986 526528 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2890624; Product type ps : putative structure; putative fimbrial-like adhesin protein 525986..526528 Escherichia coli IAI39 7151400 YP_002406527.1 CDS sfmC NC_011750.1 526747 527439 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15372038, 2553674; Product type f : factor; pilin chaperone, periplasmic 526747..527439 Escherichia coli IAI39 7152837 YP_002406528.1 CDS sfmD NC_011750.1 527470 530079 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1970114; Product type pf : putative factor; putative outer membrane export usher protein 527470..530079 Escherichia coli IAI39 7152838 YP_002406529.1 CDS sfmH NC_011750.1 530122 531099 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein 530122..531099 Escherichia coli IAI39 7152839 YP_002406530.1 CDS sfmF NC_011750.1 531201 531626 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2890624; Product type ps : putative structure; putative fimbrial protein 531201..531626 Escherichia coli IAI39 7152841 YP_002406531.1 CDS fimZ NC_011750.1 531629 532261 R activates the production of the major fimbrae protein FimA; transcriptional regulator FimZ complement(531629..532261) Escherichia coli IAI39 7152840 YP_002406532.1 CDS ECIAI39_0502 NC_011750.1 532898 533788 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 complement(532898..533788) Escherichia coli IAI39 7151833 YP_002406533.1 CDS ECIAI39_0503 NC_011750.1 533785 534111 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 complement(533785..534111) Escherichia coli IAI39 7149570 YP_002406534.1 CDS ECIAI39_0504 NC_011750.1 534073 535077 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative integrase of prophage 534073..535077 Escherichia coli IAI39 7149571 YP_002406535.1 CDS ECIAI39_0505 NC_011750.1 535070 535306 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA binding protein from phage origin 535070..535306 Escherichia coli IAI39 7149572 YP_002406536.1 CDS ECIAI39_0507 NC_011750.1 536225 537139 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 536225..537139 Escherichia coli IAI39 7149573 YP_002406537.1 CDS ECIAI39_0508 NC_011750.1 537132 537356 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 537132..537356 Escherichia coli IAI39 7149574 YP_002406538.1 CDS ECIAI39_0509 NC_011750.1 537359 537646 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 537359..537646 Escherichia coli IAI39 7149575 YP_002406539.1 CDS ECIAI39_0510 NC_011750.1 537826 539463 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA primase from prophage 537826..539463 Escherichia coli IAI39 7149576 YP_002406540.1 CDS ECIAI39_0511 NC_011750.1 539751 539996 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 539751..539996 Escherichia coli IAI39 7149577 YP_002406541.1 CDS ECIAI39_0512 NC_011750.1 539993 540442 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative single-stranded DNA-binding protein 539993..540442 Escherichia coli IAI39 7149578 YP_002406542.1 CDS ECIAI39_0513 NC_011750.1 540486 541700 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative major head protein from prophage 540486..541700 Escherichia coli IAI39 7149579 YP_002406543.1 CDS ECIAI39_0514 NC_011750.1 541710 542051 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head decoration protein from prophage 541710..542051 Escherichia coli IAI39 7149580 YP_002406544.1 CDS ECIAI39_0515 NC_011750.1 542063 542446 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 542063..542446 Escherichia coli IAI39 7149581 YP_002406545.1 CDS ECIAI39_0516 NC_011750.1 543045 544187 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(543045..544187) Escherichia coli IAI39 7149582 YP_002406546.1 CDS E NC_011750.1 544409 545185 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major head protein 544409..545185 Escherichia coli IAI39 7149583 YP_002406547.1 CDS fI NC_011750.1 545188 545625 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; DNA packaging protein from bacteriophage origin 545188..545625 Escherichia coli IAI39 7151191 YP_002406548.1 CDS fII NC_011750.1 545637 545990 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin; tail attachment protein from bacteriophage origin 545637..545990 Escherichia coli IAI39 7151321 YP_002406549.1 CDS ECIAI39_0520 NC_011750.1 546002 546580 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein Z (GpZ) 546002..546580 Escherichia coli IAI39 7151326 YP_002406550.1 CDS ECIAI39_0521 NC_011750.1 546577 546972 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein U 546577..546972 Escherichia coli IAI39 7149584 YP_002406551.1 CDS ECIAI39_0522 NC_011750.1 546950 547720 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail protein V 546950..547720 Escherichia coli IAI39 7149585 YP_002406552.1 CDS ECIAI39_0523 NC_011750.1 547736 548158 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein G 547736..548158 Escherichia coli IAI39 7149586 YP_002406553.1 CDS ECIAI39_0524 NC_011750.1 548140 548598 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein T 548140..548598 Escherichia coli IAI39 7149587 YP_002406554.1 CDS ECIAI39_0525 NC_011750.1 548567 551113 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein H 548567..551113 Escherichia coli IAI39 7149588 YP_002406555.1 CDS ECIAI39_0526 NC_011750.1 551110 551439 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein M 551110..551439 Escherichia coli IAI39 7149589 YP_002406556.1 CDS ECIAI39_0527 NC_011750.1 551439 552137 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein L 551439..552137 Escherichia coli IAI39 7149590 YP_002406557.1 CDS ECIAI39_0528 NC_011750.1 552143 552886 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber component K of prophage 552143..552886 Escherichia coli IAI39 7149591 YP_002406558.1 CDS ECIAI39_0529 NC_011750.1 552784 553455 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein I 552784..553455 Escherichia coli IAI39 7149592 YP_002406559.1 CDS ECIAI39_0530 NC_011750.1 553516 556995 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J of prophage 553516..556995 Escherichia coli IAI39 7149593 YP_002406560.1 CDS ECIAI39_0531 NC_011750.1 557063 557662 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Lom-like outer membrane protein of prophage 557063..557662 Escherichia coli IAI39 7149594 YP_002406561.1 CDS ECIAI39_0532 NC_011750.1 557721 560126 D Evidence 4 : Homologs of previously reported genes of unknown function; putative prophage side tail fiber protein 557721..560126 Escherichia coli IAI39 7149595 YP_002406562.1 CDS ECIAI39_0533 NC_011750.1 560123 560404 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 560123..560404 Escherichia coli IAI39 7149596 YP_002406563.1 CDS ECIAI39_0534 NC_011750.1 560414 561118 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 560414..561118 Escherichia coli IAI39 7149597 YP_002406564.1 CDS ECIAI39_0535 NC_011750.1 561129 561422 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 561129..561422 Escherichia coli IAI39 7149598 YP_002406565.1 CDS ybcY NC_011750.1 561616 562200 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative AdoMet-dependent methyltransferase; DLP12 prophage complement(561616..562200) Escherichia coli IAI39 7149599 YP_002406566.1 CDS ECIAI39_0538 NC_011750.1 562823 564307 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative protease complement(562823..564307) Escherichia coli IAI39 7154369 YP_002406567.1 CDS ompT NC_011750.1 564494 565447 R outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA; outer membrane protease complement(564494..565447) Escherichia coli IAI39 7149600 YP_002406568.1 CDS envY NC_011750.1 565959 566720 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6317653, 2536924; Product type r : regulator; DNA-binding transcriptional activator of porin biosynthesis complement(565959..566720) Escherichia coli IAI39 7152297 YP_002406569.1 CDS ybcH NC_011750.1 566903 567793 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(566903..567793) Escherichia coli IAI39 7151230 YP_002406570.1 CDS nfrA NC_011750.1 567794 570766 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89359086, 94042873, 94042874; Product type m : membrane component; bacteriophage N4 receptor, outer membrane subunit complement(567794..570766) Escherichia coli IAI39 7153299 YP_002406571.1 CDS cusS NC_011750.1 573140 574582 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 11283292, 11399769; Product type r : regulator; sensor kinase CusS complement(573140..574582) Escherichia coli IAI39 7152218 YP_002406572.1 CDS cusR NC_011750.1 574572 575255 R response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR complement(574572..575255) Escherichia coli IAI39 7151033 YP_002406573.1 CDS cusC NC_011750.1 575412 576794 D with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 575412..576794 Escherichia coli IAI39 7151032 YP_002406574.1 CDS cusF NC_011750.1 576818 577150 D Evidence 2b : Function of strongly homologous gene; PubMedId : 21125583, 11283292, 11399769, 12813074; Product type f : factor; periplasmic copper-binding protein 576818..577150 Escherichia coli IAI39 7151030 YP_002406575.1 CDS cusB NC_011750.1 577166 578389 D with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB 577166..578389 Escherichia coli IAI39 7151031 YP_002406576.1 CDS cusA NC_011750.1 578401 581544 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 21125583, 21178899, 21450803, 11399769, 12813074, 1711024, 7984428; Product type t : transporter; copper/silver efflux system, membrane component 578401..581544 Escherichia coli IAI39 7151029 YP_002406577.1 CDS pheP NC_011750.1 581646 583022 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91267923, 94042931, 8626334; Product type t : transporter; phenylalanine transporter 581646..583022 Escherichia coli IAI39 7151028 YP_002406578.1 CDS ybdG NC_011750.1 583103 584350 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative membrane protein; putative channel complement(583103..584350) Escherichia coli IAI39 7152391 YP_002406579.1 CDS nfnB NC_011750.1 584458 585111 R catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase complement(584458..585111) Escherichia coli IAI39 7153308 YP_002406580.1 CDS ybdF NC_011750.1 585190 585558 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(585190..585558) Escherichia coli IAI39 7152214 YP_002406581.1 CDS ybdJ NC_011750.1 585638 585886 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(585638..585886) Escherichia coli IAI39 7153307 YP_002406582.1 CDS ybdK NC_011750.1 585952 587070 R ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase complement(585952..587070) Escherichia coli IAI39 7153310 YP_002406583.1 CDS entD NC_011750.1 587796 588425 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89313305, 90132534, 91035252, 8939709, 9214294; Product type e : enzyme; phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex complement(587796..588425) Escherichia coli IAI39 7153311 YP_002406584.1 CDS ECIAI39_0558 NC_011750.1 588579 589109 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 588579..589109 Escherichia coli IAI39 7151225 YP_002406585.1 CDS ECIAI39_0559 NC_011750.1 589214 589936 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 589214..589936 Escherichia coli IAI39 7149601 YP_002406586.1 CDS fepA NC_011750.1 590026 592266 R Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA complement(590026..592266) Escherichia coli IAI39 7149602 YP_002406587.1 CDS fes NC_011750.1 592587 593711 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92291125, 94198561, 2974033; Product type e : enzyme; enterobactin/ferric enterobactin esterase 592587..593711 Escherichia coli IAI39 7151303 YP_002406588.1 CDS ybdZ NC_011750.1 593714 593932 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 593714..593932 Escherichia coli IAI39 7151309 YP_002406589.1 CDS entF NC_011750.1 593929 597810 D with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 593929..597810 Escherichia coli IAI39 7153314 YP_002406590.1 CDS fepE NC_011750.1 598025 599158 D part of the ferric enterobactin transport system; necessary for enetrobactin uptake; ferric enterobactin transport protein FepE 598025..599158 Escherichia coli IAI39 7151227 YP_002406591.1 CDS fepC NC_011750.1 599155 599970 R with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein complement(599155..599970) Escherichia coli IAI39 7151307 YP_002406592.1 CDS fepG NC_011750.1 599967 600959 R with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease complement(599967..600959) Escherichia coli IAI39 7151305 YP_002406593.1 CDS fepD NC_011750.1 600956 601960 R with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein complement(600956..601960) Escherichia coli IAI39 7151308 YP_002406594.1 CDS ybdA NC_011750.1 602071 603321 D protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 602071..603321 Escherichia coli IAI39 7151306 YP_002406595.1 CDS fepB NC_011750.1 603325 604281 R with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein complement(603325..604281) Escherichia coli IAI39 7153304 YP_002406596.1 CDS entC NC_011750.1 604470 605645 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89123153, 90165423, 90241936, 2110093, 2139473; Product type e : enzyme; isochorismate synthase 1 604470..605645 Escherichia coli IAI39 7151304 YP_002406597.1 CDS entE NC_011750.1 605655 607265 D bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 605655..607265 Escherichia coli IAI39 7151224 YP_002406598.1 CDS entB NC_011750.1 607279 608136 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20183918, 90241937, 91035252, 9485415, 97361959, 2521621, 2521622; Product type e : enzyme; isochorismatase 607279..608136 Escherichia coli IAI39 7151226 YP_002406599.1 CDS entA NC_011750.1 608136 608882 D catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 608136..608882 Escherichia coli IAI39 7151223 YP_002406600.1 CDS ybdB NC_011750.1 608885 609298 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2521621, 2521622, 15808744; Product type pe : putative enzyme; hypothetical protein 608885..609298 Escherichia coli IAI39 7151222 YP_002406601.1 CDS cstA NC_011750.1 609479 611584 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91162636, 2521622; Product type pf : putative factor; carbon starvation protein 609479..611584 Escherichia coli IAI39 7153305 YP_002406602.1 CDS ybdD NC_011750.1 611697 611894 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 611697..611894 Escherichia coli IAI39 7151025 YP_002406603.1 CDS ybdH NC_011750.1 611904 612992 R member of the iron-containing alcohol dehydrogenase family; unknown function; hypothetical protein complement(611904..612992) Escherichia coli IAI39 7153306 YP_002406604.1 CDS ybdL NC_011750.1 613101 614261 D catalyzes the transfer of an amino moiety; putative aminotransferase 613101..614261 Escherichia coli IAI39 7153309 YP_002406605.1 CDS ibrB NC_011750.1 614262 614891 R Evidence 2b : Function of strongly homologous gene; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator complement(614262..614891) Escherichia coli IAI39 7153312 YP_002406606.1 CDS ibrA NC_011750.1 614864 616084 R Evidence 2b : Function of strongly homologous gene; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator complement(614864..616084) Escherichia coli IAI39 7151748 YP_002406607.1 CDS ybdO NC_011750.1 616231 617169 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative LysR-type DNA-binding transcriptional regulator complement(616231..617169) Escherichia coli IAI39 7151746 YP_002406608.1 CDS dsbG NC_011750.1 617338 618084 R Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase complement(617338..618084) Escherichia coli IAI39 7153313 YP_002406609.1 CDS ahpC NC_011750.1 618456 619019 D with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase subunit C 618456..619019 Escherichia coli IAI39 7151175 YP_002406610.1 CDS ahpF NC_011750.1 619148 620713 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89197774, 1592833; Product type e : enzyme; alkyl hydroperoxide reductase F52a subunit 619148..620713 Escherichia coli IAI39 7150706 YP_002406611.1 CDS uspG NC_011750.1 620835 621263 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 12071968; Product type f : factor; universal stress protein UP12 complement(620835..621263) Escherichia coli IAI39 7150707 YP_002406612.1 CDS rnk NC_011750.1 621619 622029 R Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator complement(621619..622029) Escherichia coli IAI39 7153111 YP_002406613.1 CDS rna NC_011750.1 622259 623065 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90151658, 90264307, 2253883, 8188249; Product type e : enzyme; ribonuclease I complement(622259..623065) Escherichia coli IAI39 7152660 YP_002406614.1 CDS citT NC_011750.1 623179 624642 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9696764; Product type t : transporter; citrate:succinate antiporter complement(623179..624642) Escherichia coli IAI39 7152651 YP_002406615.1 CDS citG NC_011750.1 624692 625570 R catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase complement(624692..625570) Escherichia coli IAI39 7150958 YP_002406616.1 CDS citX NC_011750.1 625545 626096 R 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo- citrate lyase complement(625545..626096) Escherichia coli IAI39 7150957 YP_002406617.1 CDS citF NC_011750.1 626100 627632 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase, citrate-ACP transferase subunit alpha complement(626100..627632) Escherichia coli IAI39 7150959 YP_002406618.1 CDS citE NC_011750.1 627643 628551 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase, citryl-ACP lyase subunit beta complement(627643..628551) Escherichia coli IAI39 7150956 YP_002406619.1 CDS citD NC_011750.1 628548 628844 R acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma complement(628548..628844) Escherichia coli IAI39 7150955 YP_002406620.1 CDS citC NC_011750.1 628859 629917 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase synthetase complement(628859..629917) Escherichia coli IAI39 7150954 YP_002406621.1 CDS citA NC_011750.1 630296 631954 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11889485, 21885746, 9701802; Product type r : regulator; sensory histidine kinase in two-component regulatory system with citB 630296..631954 Escherichia coli IAI39 7150953 YP_002406622.1 CDS dpiA NC_011750.1 631923 632603 D regulates the expression of citAB in citrate fermentation; two-component response regulator DpiA 631923..632603 Escherichia coli IAI39 7150951 YP_002406623.1 CDS dcuC NC_011750.1 632644 634029 R responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC complement(632644..634029) Escherichia coli IAI39 7150952 YP_002406624.1 CDS pagP NC_011750.1 634618 635178 D catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 634618..635178 Escherichia coli IAI39 7151097 YP_002406625.1 CDS cspE NC_011750.1 635353 635562 D member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 635353..635562 Escherichia coli IAI39 7150992 YP_002406626.1 CDS crcB NC_011750.1 635616 635999 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(635616..635999) Escherichia coli IAI39 7151016 YP_002406627.1 CDS ybeM NC_011750.1 636317 636880 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amidase 636317..636880 Escherichia coli IAI39 7150993 YP_002406628.1 CDS tatE NC_011750.1 637009 637212 D TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein E 637009..637212 Escherichia coli IAI39 7153320 YP_002406629.1 CDS lipA NC_011750.1 637313 638278 R catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase complement(637313..638278) Escherichia coli IAI39 7152947 YP_002406630.1 CDS ybeF NC_011750.1 638487 639440 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12218038; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(638487..639440) Escherichia coli IAI39 7151938 YP_002406631.1 CDS lipB NC_011750.1 639699 640340 R lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B complement(639699..640340) Escherichia coli IAI39 7153318 YP_002406632.1 CDS ybeD NC_011750.1 640441 640704 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8444795; hypothetical protein complement(640441..640704) Escherichia coli IAI39 7151939 YP_002406633.1 CDS dacA NC_011750.1 640814 642025 R penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase fraction A complement(640814..642025) Escherichia coli IAI39 7153317 YP_002406634.1 CDS rlpA NC_011750.1 642165 643253 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88058785, 2644207; Product type lp : lipoprotein; rare lipoprotein A complement(642165..643253) Escherichia coli IAI39 7151076 YP_002406635.1 CDS mrdB NC_011750.1 643264 644376 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89123070, 90036736, 91072213, 3316191; Product type cp : cell process; cell wall shape-determining protein complement(643264..644376) Escherichia coli IAI39 7152639 YP_002406636.1 CDS mrdA NC_011750.1 644379 646280 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86196149, 87030266, 89174517, 2644207; Product type e : enzyme; penicillin-binding protein 2 complement(644379..646280) Escherichia coli IAI39 7152125 YP_002406637.1 CDS ybeA NC_011750.1 646311 646778 R SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(646311..646778) Escherichia coli IAI39 7152124 YP_002406638.1 CDS ybeB NC_011750.1 646782 647099 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(646782..647099) Escherichia coli IAI39 7153315 YP_002406639.1 CDS phpB NC_011750.1 647359 647970 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7929373; Product type pe : putative enzyme; putative phosphatase with phosphoglycerate mutase domain complement(647359..647970) Escherichia coli IAI39 7153316 YP_002406640.1 CDS nadD NC_011750.1 647994 648635 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(647994..648635) Escherichia coli IAI39 7152418 YP_002406641.1 CDS holA NC_011750.1 648637 649668 R required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta complement(648637..649668) Escherichia coli IAI39 7152168 YP_002406642.1 CDS rlpB NC_011750.1 649668 650249 R rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB complement(649668..650249) Escherichia coli IAI39 7151667 YP_002406643.1 CDS leuS NC_011750.1 650264 652846 R leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase complement(650264..652846) Escherichia coli IAI39 7152640 YP_002406644.1 CDS ybeL NC_011750.1 653081 653563 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11373298, 12105207, 3320963, 7567469; hypothetical protein 653081..653563 Escherichia coli IAI39 7151930 YP_002406645.1 CDS rihA NC_011750.1 653608 654543 R Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 complement(653608..654543) Escherichia coli IAI39 7153319 YP_002406646.1 CDS gltL NC_011750.1 654661 655386 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate ABC transporter ATP-binding protein complement(654661..655386) Escherichia coli IAI39 7152631 YP_002406647.1 CDS gltK NC_011750.1 655386 656060 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate ABC transporter membrane protein complement(655386..656060) Escherichia coli IAI39 7151554 YP_002406648.1 CDS gltJ NC_011750.1 656060 656800 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate ABC transporter membrane protein complement(656060..656800) Escherichia coli IAI39 7151553 YP_002406649.1 CDS gltI NC_011750.1 656970 657878 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1091636, 1091635, 10493123, 8740179, 10972807; Product type t : transporter; glutamate and aspartate transporter subunit complement(656970..657878) Escherichia coli IAI39 7150520 YP_002406650.1 CDS lnt NC_011750.1 658275 659813 R Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase complement(658275..659813) Escherichia coli IAI39 7151551 YP_002406651.1 CDS ybeX NC_011750.1 659838 660716 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1779764; Product type pt : putative transporter; putative divalent ion export protein complement(659838..660716) Escherichia coli IAI39 7151949 YP_002406652.1 CDS ybeY NC_011750.1 660806 661273 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16511207; Product type pe : putative enzyme; putative metalloprotease complement(660806..661273) Escherichia coli IAI39 7153321 YP_002406653.1 CDS ybeZ NC_011750.1 661270 662349 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12762842; Product type pe : putative enzyme; putative enzyme with nucleoside triphosphate hydrolase domain complement(661270..662349) Escherichia coli IAI39 7153322 YP_002406654.1 CDS miaB NC_011750.1 662463 663887 R catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase complement(662463..663887) Escherichia coli IAI39 7153323 YP_002406655.1 CDS ubiF NC_011750.1 664033 665208 D catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 664033..665208 Escherichia coli IAI39 7152079 YP_002406656.1 CDS ECIAI39_0630 NC_011750.1 666459 666896 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 666459..666896 Escherichia coli IAI39 7150624 YP_002406657.1 CDS asnB NC_011750.1 666938 668602 R functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B complement(666938..668602) Escherichia coli IAI39 7149603 YP_002406658.1 CDS nagD NC_011750.1 668859 669611 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16430214, 89343637; Product type e : enzyme; UMP phosphatase complement(668859..669611) Escherichia coli IAI39 7150803 YP_002406659.1 CDS nagC NC_011750.1 669659 670879 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15066032, 90136533, 91171292, 92114782, 92356048, 2190615, 2668691, 7545108; Product type r : regulator; DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine complement(669659..670879) Escherichia coli IAI39 7152174 YP_002406660.1 CDS nagA NC_011750.1 670888 672036 R catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase complement(670888..672036) Escherichia coli IAI39 7152173 YP_002406661.1 CDS nagB NC_011750.1 672096 672896 R catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase complement(672096..672896) Escherichia coli IAI39 7152171 YP_002406662.1 CDS nagE NC_011750.1 673285 675174 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunits IIABC 673285..675174 Escherichia coli IAI39 7152172 YP_002406663.1 CDS glnS NC_011750.1 675377 677041 D catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 675377..677041 Escherichia coli IAI39 7152175 YP_002406664.1 CDS ybfM NC_011750.1 677483 678889 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2118530, 9636669; Product type pt : putative transporter; putative outer membrane porin 677483..678889 Escherichia coli IAI39 7151533 YP_002406665.1 CDS ybfN NC_011750.1 678939 679265 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein 678939..679265 Escherichia coli IAI39 7153327 YP_002406666.1 CDS fur NC_011750.1 679349 679795 R negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator complement(679349..679795) Escherichia coli IAI39 7153328 YP_002406667.1 CDS ECIAI39_0641 NC_011750.1 679840 680094 D Evidence 6 : Doubtful CDS; hypothetical protein 679840..680094 Escherichia coli IAI39 7151456 YP_002406668.1 CDS fldA NC_011750.1 680084 680614 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA complement(680084..680614) Escherichia coli IAI39 7149604 YP_002406669.1 CDS ybfE NC_011750.1 680754 681047 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20223640, 12427949; Product type cp : cell process; LexA regulated protein complement(680754..681047) Escherichia coli IAI39 7151347 YP_002406670.1 CDS ybfF NC_011750.1 681187 681951 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme; hypothetical protein complement(681187..681951) Escherichia coli IAI39 7153325 YP_002406671.1 CDS seqA NC_011750.1 682136 682681 D negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 682136..682681 Escherichia coli IAI39 7153326 YP_002406672.1 CDS pgm NC_011750.1 682707 684347 D catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 682707..684347 Escherichia coli IAI39 7152829 YP_002406673.1 CDS ybfP NC_011750.1 684552 685046 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 684552..685046 Escherichia coli IAI39 7152384 YP_002406674.1 CDS ECIAI39_0648 NC_011750.1 685087 685845 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(685087..685845) Escherichia coli IAI39 7153329 YP_002406675.1 CDS ECIAI39_0649 NC_011750.1 685815 685964 R Evidence 6 : Doubtful CDS; hypothetical protein complement(685815..685964) Escherichia coli IAI39 7149605 YP_002406676.1 CDS potE NC_011750.1 686086 687405 R catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter complement(686086..687405) Escherichia coli IAI39 7149606 YP_002406677.1 CDS speF NC_011750.1 687402 689600 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92041955; Product type e : enzyme; ornithine decarboxylase complement(687402..689600) Escherichia coli IAI39 7152445 YP_002406678.1 CDS ECIAI39_0652 NC_011750.1 689723 689980 D Evidence 6 : Doubtful CDS; hypothetical protein 689723..689980 Escherichia coli IAI39 7152884 YP_002406679.1 CDS kdpE NC_011750.1 690196 690873 R response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; DNA-binding transcriptional activator KdpE complement(690196..690873) Escherichia coli IAI39 7149607 YP_002406680.1 CDS kdpD NC_011750.1 690870 693554 R sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; sensor protein KdpD complement(690870..693554) Escherichia coli IAI39 7151884 YP_002406681.1 CDS kdpC NC_011750.1 693547 694119 R One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C complement(693547..694119) Escherichia coli IAI39 7151883 YP_002406682.1 CDS kdpB NC_011750.1 694128 696176 R One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B complement(694128..696176) Escherichia coli IAI39 7151882 YP_002406683.1 CDS kdpA NC_011750.1 696199 697872 R catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A complement(696199..697872) Escherichia coli IAI39 7151881 YP_002406684.1 CDS ybfA NC_011750.1 698274 698480 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 698274..698480 Escherichia coli IAI39 7151880 YP_002406685.1 CDS ybgA NC_011750.1 698581 699090 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6325460, 8387990; hypothetical protein 698581..699090 Escherichia coli IAI39 7153324 YP_002406686.1 CDS phr NC_011750.1 699087 700505 D UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 699087..700505 Escherichia coli IAI39 7153330 YP_002406687.1 CDS ybgH NC_011750.1 700548 702029 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15175316; Product type pt : putative transporter; putative transporter complement(700548..702029) Escherichia coli IAI39 7152419 YP_002406688.1 CDS ybgI NC_011750.1 702300 703043 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14519207; putative hydrolase-oxidase 702300..703043 Escherichia coli IAI39 7153334 YP_002406689.1 CDS ybgJ NC_011750.1 703066 703722 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase subunit 703066..703722 Escherichia coli IAI39 7153335 YP_002406690.1 CDS ybgK NC_011750.1 703716 704648 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase subunit 703716..704648 Escherichia coli IAI39 7153336 YP_002406691.1 CDS ybgL NC_011750.1 704638 705372 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1729609; Product type pe : putative enzyme; LamB/YcsF family protein 704638..705372 Escherichia coli IAI39 7153337 YP_002406692.1 CDS nei NC_011750.1 705408 706199 D 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 705408..706199 Escherichia coli IAI39 7153338 YP_002406693.1 CDS abrB NC_011750.1 706196 707242 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8002588; Product type ph : phenotype; hypothetical protein complement(706196..707242) Escherichia coli IAI39 7152204 YP_002406694.1 CDS ECIAI39_0668 NC_011750.1 707422 708135 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative GntR family regulator complement(707422..708135) Escherichia coli IAI39 7150655 YP_002406695.1 CDS ECIAI39_0669 NC_011750.1 708342 709085 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Demethylmenaquinone methyltransferase 708342..709085 Escherichia coli IAI39 7149608 YP_002406696.1 CDS ECIAI39_0670 NC_011750.1 709098 710111 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative zinc-type alcohol dehydrogenase 709098..710111 Escherichia coli IAI39 7149609 YP_002406697.1 CDS ECIAI39_0671 NC_011750.1 710123 710878 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Short-chain dehydrogenase/reductase SDR 710123..710878 Escherichia coli IAI39 7149610 YP_002406698.1 CDS ECIAI39_0672 NC_011750.1 710893 711204 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 710893..711204 Escherichia coli IAI39 7149611 YP_002406699.1 CDS ECIAI39_0673 NC_011750.1 711204 712400 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Altronate dehydratase 711204..712400 Escherichia coli IAI39 7149612 YP_002406700.1 CDS ECIAI39_0674 NC_011750.1 712428 713396 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative C4-dicarboxylate-binding periplasmic protein 712428..713396 Escherichia coli IAI39 7149613 YP_002406701.1 CDS ECIAI39_0675 NC_011750.1 713420 713917 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative C4-dicarboxylate transporter small permease 713420..713917 Escherichia coli IAI39 7149614 YP_002406702.1 CDS ECIAI39_0676 NC_011750.1 713917 715227 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative C4-dicarboxylate transporter large permease 713917..715227 Escherichia coli IAI39 7149615 YP_002406703.1 CDS gltA NC_011750.1 715274 716557 R type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase complement(715274..716557) Escherichia coli IAI39 7149616 YP_002406704.1 CDS ECIAI39_0678 NC_011750.1 716763 716921 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(716763..716921) Escherichia coli IAI39 7151548 YP_002406705.1 CDS sdhC NC_011750.1 717266 717655 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6237244, 89076355, 89123360, 9521736, 99414342, 11259408, 3309132, 6383359, 9822661; Product type m : membrane component; succinate dehydrogenase cytochrome b556 large membrane subunit 717266..717655 Escherichia coli IAI39 7149617 YP_002406706.1 CDS sdhD NC_011750.1 717649 717996 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82124790, 89076355, 9521736, 99414342, 6383359; Product type m : membrane component; succinate dehydrogenase cytochrome b556 small membrane subunit 717649..717996 Escherichia coli IAI39 7152815 YP_002406707.1 CDS sdhA NC_011750.1 717996 719762 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 717996..719762 Escherichia coli IAI39 7152816 YP_002406708.1 CDS sdhB NC_011750.1 719778 720494 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 719778..720494 Escherichia coli IAI39 7152813 YP_002406709.1 CDS sucA NC_011750.1 720695 723496 D SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 720695..723496 Escherichia coli IAI39 7152814 YP_002406710.1 CDS sucB NC_011750.1 723511 724728 D component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 723511..724728 Escherichia coli IAI39 7152918 YP_002406711.1 CDS sucC NC_011750.1 724822 725988 D catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 724822..725988 Escherichia coli IAI39 7152919 YP_002406712.1 CDS sucD NC_011750.1 725988 726857 D Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 725988..726857 Escherichia coli IAI39 7152920 YP_002406713.1 CDS ECIAI39_0687 NC_011750.1 726956 728353 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(726956..728353) Escherichia coli IAI39 7152778 YP_002406714.1 CDS hutU NC_011750.1 729012 730808 D catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism; urocanate hydratase 729012..730808 Escherichia coli IAI39 7149618 YP_002406715.1 CDS ECIAI39_0689 NC_011750.1 730927 732381 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative heterocycle metabolite transporter 730927..732381 Escherichia coli IAI39 7151696 YP_002406716.1 CDS ECIAI39_0690 NC_011750.1 732383 732973 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2203753; hypothetical protein 732383..732973 Escherichia coli IAI39 7149619 YP_002406717.1 CDS hutI NC_011750.1 732937 734181 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 16198643, 16475788, 10931887; Product type e : enzyme; imidazolonepropionase 732937..734181 Escherichia coli IAI39 7149620 YP_002406718.1 CDS hutG NC_011750.1 734142 735131 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10931887, 2170334, 238937; Product type e : enzyme; formimidoylglutamase 734142..735131 Escherichia coli IAI39 7151695 YP_002406719.1 CDS ECIAI39_0693 NC_011750.1 735094 735330 R hypothetical protein complement(735094..735330) Escherichia coli IAI39 7151693 YP_002406720.1 CDS hutH NC_011750.1 735182 736852 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8239649, 8204579; Product type e : enzyme; histidine ammonia-lyase (histidase) pre-protein 735182..736852 Escherichia coli IAI39 7149621 YP_002406721.1 CDS ECIAI39_0695 NC_011750.1 737123 738028 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative LysR-like transcriptional regulator 737123..738028 Escherichia coli IAI39 7151694 YP_002406722.1 CDS ECIAI39_0696 NC_011750.1 738062 738664 R catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase complement(738062..738664) Escherichia coli IAI39 7149622 YP_002406723.1 CDS ECIAI39_0697 NC_011750.1 738674 740326 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; fumarase complement(738674..740326) Escherichia coli IAI39 7149623 YP_002406724.1 CDS ECIAI39_0698 NC_011750.1 740434 741735 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative symport protein complement(740434..741735) Escherichia coli IAI39 7149624 YP_002406725.1 CDS ECIAI39_0699 NC_011750.1 741875 742192 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(741875..742192) Escherichia coli IAI39 7149625 YP_002406726.1 CDS ECIAI39_0700 NC_011750.1 742189 743559 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11748244; Product type pe : putative enzyme; putative 3-methylaspartate ammonia-lyase, glutamate mutase complement(742189..743559) Escherichia coli IAI39 7149626 YP_002406727.1 CDS ECIAI39_0701 NC_011750.1 743563 744804 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; methylaspartate ammonia-lyase complement(743563..744804) Escherichia coli IAI39 7149627 YP_002406728.1 CDS ECIAI39_0702 NC_011750.1 744804 746249 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; glutamate mutase subunit epsilon complement(744804..746249) Escherichia coli IAI39 7149628 YP_002406729.1 CDS glmL NC_011750.1 746268 747656 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7880251; Product type e : enzyme; glutamate mutase, large subunit, B12-dependent complement(746268..747656) Escherichia coli IAI39 7149629 YP_002406730.1 CDS ECIAI39_0704 NC_011750.1 747656 748168 R converts methylaspartate to L-glutamate; methylaspartate mutase subunit S complement(747656..748168) Escherichia coli IAI39 7151519 YP_002406731.1 CDS ECIAI39_0705 NC_011750.1 748292 748459 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(748292..748459) Escherichia coli IAI39 7149630 YP_002406732.1 CDS ECIAI39_0706 NC_011750.1 748652 749074 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(748652..749074) Escherichia coli IAI39 7149631 YP_002406733.1 CDS ECIAI39_0707 NC_011750.1 749155 750099 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(749155..750099) Escherichia coli IAI39 7149632 YP_002406734.1 CDS cydA NC_011750.1 750905 752473 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87299685, 89255232, 91035243, 1689724, 1724280, 2843510, 3138232; Product type c : carrier; cytochrome d terminal oxidase subunit I 750905..752473 Escherichia coli IAI39 7149633 YP_002406735.1 CDS cydB NC_011750.1 752489 753628 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87299685, 89255232, 91035243, 2843510, 3138232; Product type c : carrier; cytochrome d terminal oxidase subunit II 752489..753628 Escherichia coli IAI39 7151042 YP_002406736.1 CDS ybgE NC_011750.1 753756 754049 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 753756..754049 Escherichia coli IAI39 7151043 YP_002406737.1 CDS ybgC NC_011750.1 754199 754603 D catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase YbgC 754199..754603 Escherichia coli IAI39 7153332 YP_002406738.1 CDS tolQ NC_011750.1 754600 755292 D membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 754600..755292 Escherichia coli IAI39 7153331 YP_002406739.1 CDS tolR NC_011750.1 755296 755724 D membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 755296..755724 Escherichia coli IAI39 7152999 YP_002406740.1 CDS tolA NC_011750.1 755789 757024 D inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 755789..757024 Escherichia coli IAI39 7153000 YP_002406741.1 CDS tolB NC_011750.1 757157 758449 D forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 757157..758449 Escherichia coli IAI39 7152996 YP_002406742.1 CDS pal NC_011750.1 758484 759005 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11790745, 87133578, 92244043, 99403391, 11173492, 2687247; Product type lp : lipoprotein; peptidoglycan-associated outer membrane lipoprotein 758484..759005 Escherichia coli IAI39 7152997 YP_002406743.1 CDS ybgF NC_011750.1 759015 759806 D periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 759015..759806 Escherichia coli IAI39 7152322 YP_002406744.1 CDS nadA NC_011750.1 760922 761965 D 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 760922..761965 Escherichia coli IAI39 7150628 YP_002406745.1 CDS pnuC NC_011750.1 762003 762722 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 219824, 90330519; Product type t : transporter; nicotinamide mononucleotide transporter 762003..762722 Escherichia coli IAI39 7152165 YP_002406746.1 CDS zitB NC_011750.1 762719 763660 R involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB complement(762719..763660) Escherichia coli IAI39 7152438 YP_002406747.1 CDS ybgS NC_011750.1 763774 764154 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(763774..764154) Escherichia coli IAI39 7154589 YP_002406748.1 CDS aroG NC_011750.1 764470 765522 D catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 764470..765522 Escherichia coli IAI39 7153339 YP_002406749.1 CDS gpmA NC_011750.1 765689 766441 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(765689..766441) Escherichia coli IAI39 7150781 YP_002406750.1 CDS galM NC_011750.1 766644 767684 R catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase complement(766644..767684) Escherichia coli IAI39 7151578 YP_002406751.1 CDS galK NC_011750.1 767678 768826 R catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase complement(767678..768826) Escherichia coli IAI39 7151473 YP_002406752.1 CDS galT NC_011750.1 768830 769876 R catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase complement(768830..769876) Escherichia coli IAI39 7151472 YP_002406753.1 CDS galE NC_011750.1 769886 770902 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89274199, 92253563, 92338916, 3022232, 6301942, 8564363, 8611559, 8931134, 9174344, 9271499, 9708982; Product type e : enzyme; UDP-galactose-4-epimerase complement(769886..770902) Escherichia coli IAI39 7151477 YP_002406754.1 CDS modF NC_011750.1 771164 772636 R contains 2 ATP-binding cassettes; involved in the transport of molybdenum; putative molybdenum transport ATP-binding protein ModF complement(771164..772636) Escherichia coli IAI39 7151470 YP_002406755.1 CDS modE NC_011750.1 772704 773492 R represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE complement(772704..773492) Escherichia coli IAI39 7152107 YP_002406756.1 CDS ybhT NC_011750.1 773621 773770 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 773621..773770 Escherichia coli IAI39 7152106 YP_002406757.1 CDS modA NC_011750.1 773937 774710 D with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein 773937..774710 Escherichia coli IAI39 7153356 YP_002406758.1 CDS modB NC_011750.1 774710 775399 D part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 774710..775399 Escherichia coli IAI39 7152102 YP_002406759.1 CDS modC NC_011750.1 775402 776460 D Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 775402..776460 Escherichia coli IAI39 7152103 YP_002406760.1 CDS ybhA NC_011750.1 776461 777279 R YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase complement(776461..777279) Escherichia coli IAI39 7152104 YP_002406761.1 CDS pgl NC_011750.1 777434 778429 D catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 777434..778429 Escherichia coli IAI39 7153340 YP_002406762.1 CDS ybhD NC_011750.1 778470 779486 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(778470..779486) Escherichia coli IAI39 7152383 YP_002406763.1 CDS insA NC_011750.1 779605 779880 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 779605..779880 Escherichia coli IAI39 7153343 YP_002406764.1 CDS insB NC_011750.1 779799 780302 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 779799..780302 Escherichia coli IAI39 7151782 YP_002406765.1 CDS ybhJ NC_011750.1 780371 782395 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11782506; Product type pe : putative enzyme; hypothetical protein 780371..782395 Escherichia coli IAI39 7151793 YP_002406766.1 CDS ybhC NC_011750.1 782466 783749 R outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family; putative pectinesterase complement(782466..783749) Escherichia coli IAI39 7153346 YP_002406767.1 CDS ECIAI39_0741 NC_011750.1 783884 784654 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12754248, 12468081, 1715186, 6271639; Product type e : enzyme; phage integrase complement(783884..784654) Escherichia coli IAI39 7153342 YP_002406768.1 CDS ECIAI39_0742 NC_011750.1 784853 785299 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 complement(784853..785299) Escherichia coli IAI39 7149634 YP_002406769.1 CDS ECIAI39_0743 NC_011750.1 785416 786939 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9353259, 10413481; Product type e : enzyme; Group II intron-encoded reverse transcriptase/maturase complement(785416..786939) Escherichia coli IAI39 7150521 YP_002406770.1 CDS ECIAI39_0744 NC_011750.1 787531 788013 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 complement(787531..788013) Escherichia coli IAI39 7149636 YP_002406771.1 CDS ECIAI39_0745 NC_011750.1 788010 788336 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 complement(788010..788336) Escherichia coli IAI39 7149637 YP_002406772.1 CDS ECIAI39_0746 NC_011750.1 788298 788900 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7626018; Product type e : enzyme; Endo-alpha-sialidase, phage head protein 788298..788900 Escherichia coli IAI39 7149638 YP_002406773.1 CDS ECIAI39_0747 NC_011750.1 789137 789292 R hypothetical protein complement(789137..789292) Escherichia coli IAI39 7149639 YP_002406774.1 CDS ybhB NC_011750.1 790398 790874 R YbhB; similar to rat and human kinase inhibitory proteins; putative kinase inhibitor protein complement(790398..790874) Escherichia coli IAI39 7152211 YP_002406775.1 CDS bioA NC_011750.1 790933 792222 R catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine--8-amino-7-oxononanoate transaminase complement(790933..792222) Escherichia coli IAI39 7153341 YP_002406776.1 CDS bioB NC_011750.1 792309 793349 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11834738, 12475249, 14704425, 14967041, 20250955, 89066784, 94170810, 94190882, 97382445, 11686925; Product type e : enzyme; biotin synthase 792309..793349 Escherichia coli IAI39 7150862 YP_002406777.1 CDS bioF NC_011750.1 793346 794500 D catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 793346..794500 Escherichia coli IAI39 7150863 YP_002406778.1 CDS bioC NC_011750.1 794487 795242 D putative methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 794487..795242 Escherichia coli IAI39 7150866 YP_002406779.1 CDS bioD NC_011750.1 795235 795912 D DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 795235..795912 Escherichia coli IAI39 7150864 YP_002406780.1 CDS uvrB NC_011750.1 796491 798512 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 796491..798512 Escherichia coli IAI39 7150865 YP_002406781.1 CDS ybhK NC_011750.1 798550 799458 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16272399; Product type pe : putative enzyme; putative transferase complement(798550..799458) Escherichia coli IAI39 7153114 YP_002406782.1 CDS moaA NC_011750.1 799855 800844 D together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 799855..800844 Escherichia coli IAI39 7153347 YP_002406783.1 CDS moaB NC_011750.1 800866 801378 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93368423; Product type pf : putative factor; molybdopterin biosynthesis protein B 800866..801378 Escherichia coli IAI39 7152095 YP_002406784.1 CDS moaC NC_011750.1 801381 801866 D MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 801381..801866 Escherichia coli IAI39 7152096 YP_002406785.1 CDS moaD NC_011750.1 801859 802104 D catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 801859..802104 Escherichia coli IAI39 7152097 YP_002406786.1 CDS moaE NC_011750.1 802106 802558 D catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin guanine dinucleotide biosynthesis protein MoaE 802106..802558 Escherichia coli IAI39 7152098 YP_002406787.1 CDS ybhL NC_011750.1 802695 803399 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 802695..803399 Escherichia coli IAI39 7152099 YP_002406788.1 CDS ybhM NC_011750.1 803606 804319 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 803606..804319 Escherichia coli IAI39 7153348 YP_002406789.1 CDS ybhN NC_011750.1 804355 805311 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(804355..805311) Escherichia coli IAI39 7153349 YP_002406790.1 CDS ybhO NC_011750.1 805311 806552 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20102623, 10634942; Product type e : enzyme; cardiolipin synthase 2 complement(805311..806552) Escherichia coli IAI39 7153350 YP_002406791.1 CDS ybhP NC_011750.1 806549 807310 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal-dependent hydrolase complement(806549..807310) Escherichia coli IAI39 7153351 YP_002406792.1 CDS ybhQ NC_011750.1 807443 807853 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 807443..807853 Escherichia coli IAI39 7153352 YP_002406793.1 CDS ybhR NC_011750.1 807815 808921 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease complement(807815..808921) Escherichia coli IAI39 7153353 YP_002406794.1 CDS ybhS NC_011750.1 808932 810065 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease complement(808932..810065) Escherichia coli IAI39 7153354 YP_002406795.1 CDS ybhF NC_011750.1 810058 811794 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein complement(810058..811794) Escherichia coli IAI39 7153355 YP_002406796.1 CDS ybhG NC_011750.1 811787 812785 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16092522; Product type pt : putative transporter; hypothetical protein complement(811787..812785) Escherichia coli IAI39 7153344 YP_002406797.1 CDS ybiH NC_011750.1 812785 813456 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(812785..813456) Escherichia coli IAI39 7153345 YP_002406798.1 CDS rhlE NC_011750.1 813685 815046 D this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 813685..815046 Escherichia coli IAI39 7153359 YP_002406799.1 CDS ECIAI39_0774 NC_011750.1 815198 815341 D hypothetical protein 815198..815341 Escherichia coli IAI39 7152619 YP_002406800.1 CDS ECIAI39_0775 NC_011750.1 815653 817665 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative toxin 815653..817665 Escherichia coli IAI39 7149641 YP_002406801.1 CDS dinG NC_011750.1 817947 820097 D helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 817947..820097 Escherichia coli IAI39 7149642 YP_002406802.1 CDS ybiB NC_011750.1 820125 821087 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; glycosyl transferase family protein 820125..821087 Escherichia coli IAI39 7151140 YP_002406803.1 CDS ybiC NC_011750.1 821228 822313 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8405966; Product type pe : putative enzyme; hypothetical protein 821228..822313 Escherichia coli IAI39 7153357 YP_002406804.1 CDS ybiJ NC_011750.1 822453 822713 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(822453..822713) Escherichia coli IAI39 7153358 YP_002406805.1 CDS ybiI NC_011750.1 822978 823244 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(822978..823244) Escherichia coli IAI39 7153361 YP_002406806.1 CDS ybiX NC_011750.1 823318 823995 R Evidence 4 : Homologs of previously reported genes of unknown function; putative hydroxylase complement(823318..823995) Escherichia coli IAI39 7153360 YP_002406807.1 CDS fiu NC_011750.1 824037 826319 R Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein; catecholate siderophore receptor Fiu complement(824037..826319) Escherichia coli IAI39 7153372 YP_002406808.1 CDS ECIAI39_0783 NC_011750.1 826338 826421 R hypothetical protein complement(826338..826421) Escherichia coli IAI39 7151339 YP_002406809.1 CDS ybiM NC_011750.1 826584 826988 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(826584..826988) Escherichia coli IAI39 7149643 YP_002406810.1 CDS ybiN NC_011750.1 827120 828046 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative SAM-dependent methyltransferase 827120..828046 Escherichia coli IAI39 7153362 YP_002406811.1 CDS ybiO NC_011750.1 828043 830268 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein complement(828043..830268) Escherichia coli IAI39 7153363 YP_002406812.1 CDS glnQ NC_011750.1 830385 831107 R similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein complement(830385..831107) Escherichia coli IAI39 7153364 YP_002406813.1 CDS glnP NC_011750.1 831104 831763 R similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease complement(831104..831763) Escherichia coli IAI39 7151532 YP_002406814.1 CDS glnH NC_011750.1 831902 832648 R similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein complement(831902..832648) Escherichia coli IAI39 7151531 YP_002406815.1 CDS dps NC_011750.1 833052 833555 R binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps complement(833052..833555) Escherichia coli IAI39 7151528 YP_002406816.1 CDS rhtA NC_011750.1 833855 834742 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12648727, 8021175; Product type t : transporter; threonine and homoserine efflux system complement(833855..834742) Escherichia coli IAI39 7151171 YP_002406817.1 CDS ompX NC_011750.1 835095 835610 D OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 835095..835610 Escherichia coli IAI39 7152622 YP_002406818.1 CDS ybiP NC_011750.1 835659 837242 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16514146; Product type pe : putative enzyme; hypothetical protein complement(835659..837242) Escherichia coli IAI39 7152299 YP_002406819.1 CDS mntR NC_011750.1 837828 838295 D Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 837828..838295 Escherichia coli IAI39 7152776 YP_002406820.1 CDS ybiR NC_011750.1 838292 839410 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 838292..839410 Escherichia coli IAI39 7152094 YP_002406821.1 CDS ybiS NC_011750.1 839469 840389 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10493123, 9298646; hypothetical protein complement(839469..840389) Escherichia coli IAI39 7153366 YP_002406822.1 CDS ybiT NC_011750.1 840608 842200 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11916677; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 840608..842200 Escherichia coli IAI39 7153367 YP_002406823.1 CDS ybiU NC_011750.1 842450 843709 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(842450..843709) Escherichia coli IAI39 7153368 YP_002406824.1 CDS ybiV NC_011750.1 843861 844676 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15657928; Product type e : enzyme; type II HAD phosphatase complement(843861..844676) Escherichia coli IAI39 7153369 YP_002406825.1 CDS ybiW NC_011750.1 844822 847254 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16218870; Product type pe : putative enzyme; putative glycyl radical cofactor protein complement(844822..847254) Escherichia coli IAI39 7153370 YP_002406826.1 CDS ybiY NC_011750.1 847260 848186 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15581584; Product type pe : putative enzyme; putative AdoMet-dependent glycyl radical activating enzyme complement(847260..848186) Escherichia coli IAI39 7153371 YP_002406827.1 CDS fsaA NC_011750.1 848290 848952 D similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 848290..848952 Escherichia coli IAI39 7153373 YP_002406828.1 CDS moeB NC_011750.1 849130 849879 R ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB complement(849130..849879) Escherichia coli IAI39 7151430 YP_002406829.1 CDS moeA NC_011750.1 849879 851114 R is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA complement(849879..851114) Escherichia coli IAI39 7152109 YP_002406830.1 CDS iaaA NC_011750.1 851318 852283 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15159592, 20508248, 3045084, 7984428; Product type e : enzyme; L-asparaginase 851318..852283 Escherichia coli IAI39 7152108 YP_002406831.1 CDS yliA NC_011750.1 852303 854141 D with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 852303..854141 Escherichia coli IAI39 7151741 YP_002406832.1 CDS yliB NC_011750.1 854161 855699 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17366475; Product type pt : putative transporter; putative peptide ABC transporter periplasmic-binding protein 854161..855699 Escherichia coli IAI39 7154370 YP_002406833.1 CDS yliC NC_011750.1 855717 856637 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative peptide ABC transporter permease 855717..856637 Escherichia coli IAI39 7154371 YP_002406834.1 CDS yliD NC_011750.1 856640 857551 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative peptide ABC transporter permease 856640..857551 Escherichia coli IAI39 7154372 YP_002406835.1 CDS yliE NC_011750.1 857729 860077 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 857729..860077 Escherichia coli IAI39 7154373 YP_002406836.1 CDS yliF NC_011750.1 860085 861413 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type pe : putative enzyme; putative diguanylate cyclase 860085..861413 Escherichia coli IAI39 7154374 YP_002406837.1 CDS ECIAI39_0812 NC_011750.1 861483 861812 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(861483..861812) Escherichia coli IAI39 7154375 YP_002406838.1 CDS ECIAI39_0813 NC_011750.1 861802 862188 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(861802..862188) Escherichia coli IAI39 7149644 YP_002406839.1 CDS rimO NC_011750.1 862414 863739 R catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase complement(862414..863739) Escherichia coli IAI39 7149645 YP_002406840.1 CDS bssR NC_011750.1 863952 864335 D BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 863952..864335 Escherichia coli IAI39 7154376 YP_002406841.1 CDS yliI NC_011750.1 864446 865561 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16522795, 16864586; Product type e : enzyme; PQQ-dependent aldose sugar dehydrogenase (asd) 864446..865561 Escherichia coli IAI39 7150876 YP_002406842.1 CDS yliJ NC_011750.1 865558 866184 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glutathione S-transferase complement(865558..866184) Escherichia coli IAI39 7154377 YP_002406843.1 CDS dacC NC_011750.1 866431 867633 D penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase fraction C 866431..867633 Escherichia coli IAI39 7154378 YP_002406844.1 CDS deoR NC_011750.1 867680 868438 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89231635, 89336786, 92231401, 2994018; Product type r : regulator; DNA-binding transcriptional repressor DeoR complement(867680..868438) Escherichia coli IAI39 7151078 YP_002406845.1 CDS ybjG NC_011750.1 868496 869092 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15778224; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase complement(868496..869092) Escherichia coli IAI39 7151121 YP_002406846.1 CDS cmr NC_011750.1 869377 870609 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10022825, 12578981, 14688269, 21217867, 21450803, 9079913, 9644262, 99030337, 8655497; Product type t : transporter; multidrug efflux system protein 869377..870609 Escherichia coli IAI39 7153377 YP_002406847.1 CDS ybjH NC_011750.1 870650 870934 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(870650..870934) Escherichia coli IAI39 7150970 YP_002406848.1 CDS ybjI NC_011750.1 871019 871834 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme; putative phosphatase complement(871019..871834) Escherichia coli IAI39 7153378 YP_002406849.1 CDS ybjJ NC_011750.1 871834 873042 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(871834..873042) Escherichia coli IAI39 7153379 YP_002406850.1 CDS ybjK NC_011750.1 873126 873662 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 873126..873662 Escherichia coli IAI39 7153380 YP_002406851.1 CDS ybjL NC_011750.1 873837 875522 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein complement(873837..875522) Escherichia coli IAI39 7152777 YP_002406852.1 CDS ybjM NC_011750.1 875792 876169 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 875792..876169 Escherichia coli IAI39 7153382 YP_002406853.1 CDS grxA NC_011750.1 876199 876456 R functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 1 complement(876199..876456) Escherichia coli IAI39 7153383 YP_002406854.1 CDS ybjC NC_011750.1 876616 876903 D YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 876616..876903 Escherichia coli IAI39 7151588 YP_002406855.1 CDS nfsA NC_011750.1 876887 877609 D NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 876887..877609 Escherichia coli IAI39 7153374 YP_002406856.1 CDS rimK NC_011750.1 877670 878572 D responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 877670..878572 Escherichia coli IAI39 7152219 YP_002406857.1 CDS ybjN NC_011750.1 878660 879136 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 878660..879136 Escherichia coli IAI39 7152636 YP_002406858.1 CDS ECIAI39_0833 NC_011750.1 879342 879503 D hypothetical protein 879342..879503 Escherichia coli IAI39 7153384 YP_002406859.1 CDS potF NC_011750.1 879487 880599 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992, 9651355, 9298646, 8416922; Product type t : transporter; putrescine ABC transporter periplasmic-binding protein 879487..880599 Escherichia coli IAI39 7149646 YP_002406860.1 CDS potG NC_011750.1 880694 881827 D part of the PotFGHI ATP-dependent putrescine transporter; putrescine transporter ATP-binding subunit 880694..881827 Escherichia coli IAI39 7152446 YP_002406861.1 CDS potH NC_011750.1 881837 882790 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992; Product type t : transporter; putrescine ABC transporter membrane protein 881837..882790 Escherichia coli IAI39 7152447 YP_002406862.1 CDS potI NC_011750.1 882787 883632 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992; Product type t : transporter; putrescine ABC transporter membrane protein 882787..883632 Escherichia coli IAI39 7152448 YP_002406863.1 CDS ybjO NC_011750.1 883692 884180 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 883692..884180 Escherichia coli IAI39 7152449 YP_002406864.1 CDS rumB NC_011750.1 884221 885348 D RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 884221..885348 Escherichia coli IAI39 7153385 YP_002406865.1 CDS artJ NC_011750.1 885377 886108 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93273744, 9298646, 9600841, 8801422; Product type t : transporter; arginine ABC transporter subunit periplasmic-binding protein complement(885377..886108) Escherichia coli IAI39 7152763 YP_002406866.1 CDS artM NC_011750.1 886400 887068 R with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM complement(886400..887068) Escherichia coli IAI39 7150791 YP_002406867.1 CDS artQ NC_011750.1 887068 887784 R with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ complement(887068..887784) Escherichia coli IAI39 7150792 YP_002406868.1 CDS artI NC_011750.1 887791 888522 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93273744, 9298646, 9600841, 8801422, 9740056; Product type t : transporter; arginine ABC transporter subunit periplasmic-binding protein complement(887791..888522) Escherichia coli IAI39 7150794 YP_002406869.1 CDS artP NC_011750.1 888540 889268 R With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit complement(888540..889268) Escherichia coli IAI39 7150790 YP_002406870.1 CDS ECIAI39_0846 NC_011750.1 890616 892418 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 890616..892418 Escherichia coli IAI39 7153386 YP_002406871.1 CDS ybjQ NC_011750.1 892629 892952 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 892629..892952 Escherichia coli IAI39 7149647 YP_002406872.1 CDS ybjR NC_011750.1 892949 893779 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cell wall amidase and lipoprotein 892949..893779 Escherichia coli IAI39 7153387 YP_002406873.1 CDS ybjS NC_011750.1 893776 894789 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P)H-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain complement(893776..894789) Escherichia coli IAI39 7153388 YP_002406874.1 CDS ybjT NC_011750.1 894888 896318 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(894888..896318) Escherichia coli IAI39 7153389 YP_002406875.1 CDS ltaE NC_011750.1 896329 897330 R low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase complement(896329..897330) Escherichia coli IAI39 7153390 YP_002406876.1 CDS poxB NC_011750.1 897367 899085 R catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase complement(897367..899085) Escherichia coli IAI39 7151980 YP_002406877.1 CDS hcr NC_011750.1 899218 900186 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20117674; Product type e : enzyme; HCP oxidoreductase, NADH-dependent complement(899218..900186) Escherichia coli IAI39 7152451 YP_002406878.1 CDS hcp NC_011750.1 900198 901850 R catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase complement(900198..901850) Escherichia coli IAI39 7151616 YP_002406879.1 CDS ybjE NC_011750.1 901994 902893 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(901994..902893) Escherichia coli IAI39 7151615 YP_002406880.1 CDS ECIAI39_0857 NC_011750.1 903233 904258 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase, IS110 family 903233..904258 Escherichia coli IAI39 7149648 YP_002406881.1 CDS yohG NC_011750.1 905415 906503 D may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance outer membrane protein MdtQ 905415..906503 Escherichia coli IAI39 7149649 YP_002406882.1 CDS yohF NC_011750.1 906556 907317 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; acetoin dehydrogenase 906556..907317 Escherichia coli IAI39 7154456 YP_002406883.1 CDS yohD NC_011750.1 907436 908014 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(907436..908014) Escherichia coli IAI39 7154455 YP_002406884.1 CDS yohC NC_011750.1 908184 908771 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 908184..908771 Escherichia coli IAI39 7154454 YP_002406885.1 CDS pbpG NC_011750.1 908945 909877 D specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase 908945..909877 Escherichia coli IAI39 7154453 YP_002406886.1 CDS dld NC_011750.1 909916 911673 R component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase complement(909916..911673) Escherichia coli IAI39 7152350 YP_002406887.1 CDS bglX NC_011750.1 911828 914125 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96303506; Product type e : enzyme; beta-D-glucoside glucohydrolase 911828..914125 Escherichia coli IAI39 7151148 YP_002406888.1 CDS yehZ NC_011750.1 914377 915294 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15251200; Product type pt : putative transporter; putative ABC transporter periplasmic-binding protein 914377..915294 Escherichia coli IAI39 7150861 YP_002406889.1 CDS yehY NC_011750.1 915301 916458 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease 915301..916458 Escherichia coli IAI39 7153766 YP_002406890.1 CDS yehX NC_011750.1 916451 917377 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein transporter 916451..917377 Escherichia coli IAI39 7153765 YP_002406891.1 CDS yehW NC_011750.1 917382 918113 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease 917382..918113 Escherichia coli IAI39 7153764 YP_002406892.1 CDS yohO NC_011750.1 918094 918201 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(918094..918201) Escherichia coli IAI39 7153763 YP_002406893.1 CDS mlrA NC_011750.1 918261 918908 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11489123; Product type r : regulator; DNA-binding transcriptional regulator complement(918261..918908) Escherichia coli IAI39 7154461 YP_002406894.1 CDS ECIAI39_0871 NC_011750.1 918983 919393 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11686382, 11282477, 9562894, 8878031; Product type pe : putative enzyme; putative lambdoid prophage integrase complement(918983..919393) Escherichia coli IAI39 7152088 YP_002406895.1 CDS ECIAI39_0872 NC_011750.1 919480 919926 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 complement(919480..919926) Escherichia coli IAI39 7149650 YP_002406896.1 CDS ECIAI39_0873 NC_011750.1 920043 921566 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9353259, 10413481; Product type e : enzyme; Group II intron-encoded reverse transcriptase/maturase complement(920043..921566) Escherichia coli IAI39 7150522 YP_002406897.1 CDS ECIAI39_0874 NC_011750.1 922158 922640 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 complement(922158..922640) Escherichia coli IAI39 7149652 YP_002406898.1 CDS ECIAI39_0875 NC_011750.1 922637 922963 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 complement(922637..922963) Escherichia coli IAI39 7149653 YP_002406899.1 CDS ECIAI39_0876 NC_011750.1 923080 925929 D Evidence 2b : Function of strongly homologous gene; PubMedId : 11686382, 11282477, 9562894, 8878031; Product type f : factor; tail length tape measure protein 923080..925929 Escherichia coli IAI39 7149654 YP_002406900.1 CDS ECIAI39_0877 NC_011750.1 925922 926263 D Evidence 2b : Function of strongly homologous gene; PubMedId : 11686382, 11282477, 9562894, 8878031; Product type f : factor; minor tail protein M 925922..926263 Escherichia coli IAI39 7149655 YP_002406901.1 CDS ECIAI39_0878 NC_011750.1 926263 926961 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein L 926263..926961 Escherichia coli IAI39 7149656 YP_002406902.1 CDS ECIAI39_0879 NC_011750.1 926972 927715 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail fiber component K 926972..927715 Escherichia coli IAI39 7149657 YP_002406903.1 CDS ECIAI39_0880 NC_011750.1 927613 928293 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein I 927613..928293 Escherichia coli IAI39 7149658 YP_002406904.1 CDS ECIAI39_0881 NC_011750.1 928637 932329 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J 928637..932329 Escherichia coli IAI39 7149659 YP_002406905.1 CDS ECIAI39_0882 NC_011750.1 932398 932997 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Lom-like outer membrane protein of prophage 932398..932997 Escherichia coli IAI39 7149660 YP_002406906.1 CDS ECIAI39_0883 NC_011750.1 933149 935209 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 933149..935209 Escherichia coli IAI39 7149661 YP_002406907.1 CDS ECIAI39_0884 NC_011750.1 935206 935484 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 935206..935484 Escherichia coli IAI39 7149662 YP_002406908.1 CDS ECIAI39_0885 NC_011750.1 935494 935790 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 935494..935790 Escherichia coli IAI39 7149663 YP_002406909.1 CDS ECIAI39_0886 NC_011750.1 935908 936156 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative damage-inducible protein dinI-like complement(935908..936156) Escherichia coli IAI39 7149664 YP_002406910.1 CDS yehU NC_011750.1 936671 938356 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15522865, 15322361; Product type rc : receptor; sensory kinase in two-component system with YehT 936671..938356 Escherichia coli IAI39 7149665 YP_002406911.1 CDS yehT NC_011750.1 938353 939072 D unknown function; when overproduced it confers drug-resistance; putative two-component response-regulatory protein YehT 938353..939072 Escherichia coli IAI39 7153762 YP_002406912.1 CDS yehS NC_011750.1 939119 939589 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 939119..939589 Escherichia coli IAI39 7153761 YP_002406913.1 CDS yehR NC_011750.1 939630 940091 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type lp : lipoprotein; hypothetical protein complement(939630..940091) Escherichia coli IAI39 7153760 YP_002406914.1 CDS yehQ NC_011750.1 940216 942216 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(940216..942216) Escherichia coli IAI39 7153759 YP_002406915.1 CDS yehP NC_011750.1 942213 943349 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(942213..943349) Escherichia coli IAI39 7153758 YP_002406916.1 CDS yehM NC_011750.1 943342 945621 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(943342..945621) Escherichia coli IAI39 7153757 YP_002406917.1 CDS yehL NC_011750.1 945632 946720 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16428726; Product type pf : putative factor; putative ABC superfamily protein complement(945632..946720) Escherichia coli IAI39 7153756 YP_002406918.1 CDS yehK NC_011750.1 947424 947741 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(947424..947741) Escherichia coli IAI39 7153755 YP_002406919.1 CDS yehI NC_011750.1 947802 951440 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(947802..951440) Escherichia coli IAI39 7153754 YP_002406920.1 CDS insA NC_011750.1 951580 951855 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 951580..951855 Escherichia coli IAI39 7153753 YP_002406921.1 CDS insB NC_011750.1 951774 952277 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 951774..952277 Escherichia coli IAI39 7151783 YP_002406922.1 CDS ECIAI39_0900 NC_011750.1 955451 956011 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2156810; hypothetical protein complement(955451..956011) Escherichia coli IAI39 7149666 YP_002406923.1 CDS ECIAI39_0901 NC_011750.1 956024 959830 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2156810; Product type ph : phenotype; putative molybdate metabolism protein complement(956024..959830) Escherichia coli IAI39 7149667 YP_002406924.1 CDS metG NC_011750.1 959971 962004 R methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase complement(959971..962004) Escherichia coli IAI39 7149668 YP_002406925.1 CDS mrp NC_011750.1 962136 963245 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91080852, 15601724, 2259334; Product type t : transporter; putative ATPase 962136..963245 Escherichia coli IAI39 7152055 YP_002406926.1 CDS yehE NC_011750.1 963508 963789 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 963508..963789 Escherichia coli IAI39 7152129 YP_002406927.1 CDS ECIAI39_0905 NC_011750.1 963713 963895 R hypothetical protein complement(963713..963895) Escherichia coli IAI39 7153752 YP_002406928.1 CDS yehD NC_011750.1 964085 964627 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein 964085..964627 Escherichia coli IAI39 7149669 YP_002406929.1 CDS yehC NC_011750.1 964708 965382 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative membrane-associated pilin chaperone 964708..965382 Escherichia coli IAI39 7153751 YP_002406930.1 CDS yehB NC_011750.1 965398 967878 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 965398..967878 Escherichia coli IAI39 7153750 YP_002406931.1 CDS yehA NC_011750.1 967894 968928 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative exported fimbrial-like adhesin protein 967894..968928 Escherichia coli IAI39 7153749 YP_002406932.1 CDS yohN NC_011750.1 969010 969528 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(969010..969528) Escherichia coli IAI39 7153748 YP_002406933.1 CDS rncA NC_011750.1 969567 970364 R membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA complement(969567..970364) Escherichia coli IAI39 7154460 YP_002406934.1 CDS yohL NC_011750.1 970485 970757 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 970485..970757 Escherichia coli IAI39 7152654 YP_002406935.1 CDS thiM NC_011750.1 970980 971768 D catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 970980..971768 Escherichia coli IAI39 7150523 YP_002406936.1 CDS thiD NC_011750.1 971765 972565 D catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 971765..972565 Escherichia coli IAI39 7152973 YP_002406937.1 CDS yegX NC_011750.1 972630 973448 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-bound hydrolase 972630..973448 Escherichia coli IAI39 7152966 YP_002406938.1 CDS yegW NC_011750.1 973500 974246 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 973500..974246 Escherichia coli IAI39 7153747 YP_002406939.1 CDS yegV NC_011750.1 974220 975185 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative kinase complement(974220..975185) Escherichia coli IAI39 7153746 YP_002406940.1 CDS yegU NC_011750.1 975182 976186 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative (phospho)hydrolase complement(975182..976186) Escherichia coli IAI39 7153745 YP_002406941.1 CDS yegT NC_011750.1 976183 977460 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative hydrophilic substrate transporter; MFS superfamily complement(976183..977460) Escherichia coli IAI39 7153744 YP_002406942.1 CDS fbaB NC_011750.1 977717 978769 D catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase 977717..978769 Escherichia coli IAI39 7153743 YP_002406943.1 CDS gatY NC_011750.1 978998 979852 D catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 978998..979852 Escherichia coli IAI39 7151280 YP_002406944.1 CDS gatZ NC_011750.1 979881 981143 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976750, 97113438, 7772602, 8932697; Product type e : enzyme; D-tagatose 1,6-bisphosphate aldolase 2 subunit 979881..981143 Escherichia coli IAI39 7151491 YP_002406945.1 CDS gatA NC_011750.1 981153 981605 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIA 981153..981605 Escherichia coli IAI39 7151492 YP_002406946.1 CDS gatB NC_011750.1 981636 981920 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIB 981636..981920 Escherichia coli IAI39 7151486 YP_002406947.1 CDS gatC NC_011750.1 981924 983279 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76024805, 77192083, 97113438, 7772602; Product type t : transporter; galactitol-specific enzyme IIC component of PTS 981924..983279 Escherichia coli IAI39 7151487 YP_002406948.1 CDS gatD NC_011750.1 983327 984367 D Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase 983327..984367 Escherichia coli IAI39 7151488 YP_002406949.1 CDS gatR NC_011750.1 984467 985246 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7772602; Product type r : regulator; Galactitol utilization operon repressor 984467..985246 Escherichia coli IAI39 7151489 YP_002406950.1 CDS yegS NC_011750.1 985328 986227 R cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase complement(985328..986227) Escherichia coli IAI39 7151490 YP_002406951.1 CDS yegR NC_011750.1 986640 986957 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 986640..986957 Escherichia coli IAI39 7153742 YP_002406952.1 CDS yegQ NC_011750.1 987287 988648 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase complement(987287..988648) Escherichia coli IAI39 7152784 YP_002406953.1 CDS ECIAI39_0931 NC_011750.1 988751 989047 R Evidence 4 : Homologs of previously reported genes of unknown function; putative plasmid stabilisation system protein complement(988751..989047) Escherichia coli IAI39 7153740 YP_002406954.1 CDS ECIAI39_0932 NC_011750.1 989049 989345 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(989049..989345) Escherichia coli IAI39 7149670 YP_002406955.1 CDS yegP NC_011750.1 989554 989886 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(989554..989886) Escherichia coli IAI39 7149671 YP_002406956.1 CDS ECIAI39_0934 NC_011750.1 989926 990120 R Evidence 6 : Doubtful CDS; hypothetical protein complement(989926..990120) Escherichia coli IAI39 7153739 YP_002406957.1 CDS baeR NC_011750.1 990077 990799 R response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; DNA-binding transcriptional regulator BaeR complement(990077..990799) Escherichia coli IAI39 7149672 YP_002406958.1 CDS baeS NC_011750.1 990796 992199 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94110256, 8282725; Product type r : regulator; signal transduction histidine-protein kinase BaeS complement(990796..992199) Escherichia coli IAI39 7150834 YP_002406959.1 CDS mdtD NC_011750.1 992196 993611 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12107134, 21450803, 8282725; Product type t : transporter; multidrug efflux system protein MdtE complement(992196..993611) Escherichia coli IAI39 7150835 YP_002406960.1 CDS mdtC NC_011750.1 993612 996689 R Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC complement(993612..996689) Escherichia coli IAI39 7152031 YP_002406961.1 CDS mdtB NC_011750.1 996690 999812 R Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtB complement(996690..999812) Escherichia coli IAI39 7152030 YP_002406962.1 CDS mdtA NC_011750.1 999812 1001059 R Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtA complement(999812..1001059) Escherichia coli IAI39 7152029 YP_002406963.1 CDS yegL NC_011750.1 1002276 1002935 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1002276..1002935 Escherichia coli IAI39 7152782 YP_002406964.1 CDS yegK NC_011750.1 1002932 1003693 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1002932..1003693 Escherichia coli IAI39 7153738 YP_002406965.1 CDS yegI NC_011750.1 1003681 1005630 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1003681..1005630 Escherichia coli IAI39 7153737 YP_002406966.1 CDS yegD NC_011750.1 1005643 1006995 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 6094528, 7940673, 7984428; Product type pf : putative factor; putative chaperone complement(1005643..1006995) Escherichia coli IAI39 7153736 YP_002406967.1 CDS alkA NC_011750.1 1007138 1007986 D inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyl-adenine DNA glycosylase II 1007138..1007986 Escherichia coli IAI39 7153733 YP_002406968.1 CDS yegE NC_011750.1 1008024 1011341 R contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction; putative sensor protein complement(1008024..1011341) Escherichia coli IAI39 7150713 YP_002406969.1 CDS udk NC_011750.1 1011659 1012300 D functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 1011659..1012300 Escherichia coli IAI39 7153734 YP_002406970.1 CDS dcd NC_011750.1 1012392 1012973 D Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 1012392..1012973 Escherichia coli IAI39 7153078 YP_002406971.1 CDS asmA NC_011750.1 1012995 1014848 D YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; putative assembly protein 1012995..1014848 Escherichia coli IAI39 7151090 YP_002406972.1 CDS ECIAI39_0950 NC_011750.1 1014901 1015209 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1014901..1015209) Escherichia coli IAI39 7150801 YP_002406973.1 CDS ECIAI39_0951 NC_011750.1 1015181 1015519 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1015181..1015519) Escherichia coli IAI39 7149673 YP_002406974.1 CDS yegH NC_011750.1 1015594 1017177 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein complement(1015594..1017177) Escherichia coli IAI39 7149674 YP_002406975.1 CDS wza NC_011750.1 1017836 1018975 D Evidence 2b : Function of strongly homologous gene; PubMedId : 15090537, 96326333, 8759852, 8763957; Product type lp : lipoprotein; capsular polysaccharide translocation lipoprotein 1017836..1018975 Escherichia coli IAI39 7153735 YP_002406976.1 CDS wzb NC_011750.1 1018981 1019424 D Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase 1018981..1019424 Escherichia coli IAI39 7153162 YP_002406977.1 CDS wzc NC_011750.1 1019427 1021589 D Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase 1019427..1021589 Escherichia coli IAI39 7153163 YP_002406978.1 CDS wcaA NC_011750.1 1021682 1022521 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme; putative glycosyl transferase 1021682..1022521 Escherichia coli IAI39 7153164 YP_002406979.1 CDS wcaB NC_011750.1 1022524 1023012 D acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; putative colanic acid biosynthesis acetyltransferase WcaB 1022524..1023012 Escherichia coli IAI39 7153150 YP_002406980.1 CDS wcaC NC_011750.1 1023009 1024226 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme; putative glycosyl transferase 1023009..1024226 Escherichia coli IAI39 7153151 YP_002406981.1 CDS wcaD NC_011750.1 1024201 1025418 D essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance; putative colanic acid biosynthesis protein 1024201..1025418 Escherichia coli IAI39 7153152 YP_002406982.1 CDS wcaE NC_011750.1 1025429 1026175 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11371548, 96326333, 8759852; Product type pe : putative enzyme; putative glycosyl transferase 1025429..1026175 Escherichia coli IAI39 7153153 YP_002406983.1 CDS wcaF NC_011750.1 1026191 1026739 D acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); putative colanic acid biosynthesis acetyltransferase WcaF 1026191..1026739 Escherichia coli IAI39 7153154 YP_002406984.1 CDS gmd NC_011750.1 1026766 1027887 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20139699, 97400210, 10673432, 7815923, 8759852, 9257704, 14299611; Product type e : enzyme; GDP-D-mannose dehydratase, NAD(P)-binding 1026766..1027887 Escherichia coli IAI39 7153155 YP_002406985.1 CDS fcl NC_011750.1 1027890 1028855 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 98132401, 9862812, 7815923, 8759852, 9473059; Product type e : enzyme; bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase and GDP-4-dehydro-6-L-deoxygalactose reductase 1027890..1028855 Escherichia coli IAI39 7151562 YP_002406986.1 CDS nudD NC_011750.1 1028858 1029337 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 10913267, 7592609, 7815923, 8759852; Product type e : enzyme; GDP-mannose mannosyl hydrolase 1028858..1029337 Escherichia coli IAI39 7151282 YP_002406987.1 CDS wcaI NC_011750.1 1029334 1030557 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15670885, 96326333; Product type pe : putative enzyme; putative glycosyl transferase 1029334..1030557 Escherichia coli IAI39 7152264 YP_002406988.1 CDS cpsB NC_011750.1 1030560 1031996 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82100097, 85006781, 92048476, 93122523, 96326333, 7815923, 8759852; Product type e : enzyme; mannose-1-phosphate guanyltransferase 1030560..1031996 Escherichia coli IAI39 7153156 YP_002406989.1 CDS cpsG NC_011750.1 1032098 1033468 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106949, 96326333, 7815923, 8759852; Product type e : enzyme; phosphomannomutase 1032098..1033468 Escherichia coli IAI39 7150986 YP_002406990.1 CDS wcaJ NC_011750.1 1033523 1034917 D WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid; putative UDP-glucose lipid carrier transferase 1033523..1034917 Escherichia coli IAI39 7150987 YP_002406991.1 CDS wzxC NC_011750.1 1034919 1036397 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 8759852; Product type pt : putative transporter; colanic acid exporter 1034919..1036397 Escherichia coli IAI39 7153157 YP_002406992.1 CDS wcaK NC_011750.1 1036470 1037750 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333, 8759852, 11004393; Product type pe : putative enzyme; putative pyruvyl transferase 1036470..1037750 Escherichia coli IAI39 7153166 YP_002406993.1 CDS wcaL NC_011750.1 1037747 1038967 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : putative enzyme; putative glycosyl transferase 1037747..1038967 Escherichia coli IAI39 7153158 YP_002406994.1 CDS wcaM NC_011750.1 1038978 1040372 D WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid; putative colanic acid biosynthesis protein 1038978..1040372 Escherichia coli IAI39 7153159 YP_002406995.1 CDS galF NC_011750.1 1040547 1041440 D together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalF 1040547..1041440 Escherichia coli IAI39 7153160 YP_002406996.1 CDS rmlB NC_011750.1 1041813 1042898 D NAD(P) binding; catalyzes the formation of dTDP-4-dehydro-6-deoxy-D-glucose from dTDP-glucose; dTDP-glucose 4,6 dehydratase 1041813..1042898 Escherichia coli IAI39 7151471 YP_002406997.1 CDS rmlD NC_011750.1 1042898 1043797 D with dTDP-4-dehydrorhamnose 3,5-epimerase forms a complex known as dTDP-L-rhamnose synthetase; catalyzes the reduction of dTDP-4-dehydro-6-deoxy-L-mannose to dTDP-L-rhamnose; dTDP-4-dehydrorhamnose reductase 1042898..1043797 Escherichia coli IAI39 7152647 YP_002406998.1 CDS rmlA NC_011750.1 1043856 1044734 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 5833803, 92120472, 94292435, 96032389, 7517390, 7517391, 14253441; Product type e : enzyme; glucose-1-phosphate thymidylyltransferase 1043856..1044734 Escherichia coli IAI39 7152649 YP_002406999.1 CDS rmlC NC_011750.1 1044739 1045284 D Evidence 2b : Function of strongly homologous gene; PubMedId : 12949172, 15695810, 15932984; Product type e : enzyme; dTDP-6-deoxy-D-glucose-3,5 epimerase 1044739..1045284 Escherichia coli IAI39 7152646 YP_002407000.1 CDS wzx NC_011750.1 1045285 1046718 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17086202, 16816184; Product type e : enzyme; O-antigen flippase 1045285..1046718 Escherichia coli IAI39 7152648 YP_002407001.1 CDS vioA NC_011750.1 1046721 1047833 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10517601; Product type e : enzyme; dTDP-6-deoxy-D-xylo-4-hexulose aminotransferase 1046721..1047833 Escherichia coli IAI39 7153165 YP_002407002.1 CDS vioB NC_011750.1 1047835 1048413 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10517601; Product type e : enzyme; dTDP-viosamine N-acetyltransferase 1047835..1048413 Escherichia coli IAI39 7153127 YP_002407003.1 CDS wbbA NC_011750.1 1048410 1049156 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10074083, 12591881; Product type e : enzyme; glycosyltransferase WbbA 1048410..1049156 Escherichia coli IAI39 7153128 YP_002407004.1 CDS wbbB NC_011750.1 1049156 1049977 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15625181, 12591881; Product type e : enzyme; component WbbB of exported sugar polymer 1049156..1049977 Escherichia coli IAI39 7153146 YP_002407005.1 CDS wzy NC_011750.1 1049974 1051149 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17086202, 16816184; Product type e : enzyme; O-antigen polymerase Wzy 1049974..1051149 Escherichia coli IAI39 7153147 YP_002407006.1 CDS wbbC NC_011750.1 1051146 1052258 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15625181; Product type e : enzyme; glycosyltransferase WbbC 1051146..1052258 Escherichia coli IAI39 7153168 YP_002407007.1 CDS wbbD NC_011750.1 1052248 1053075 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15625181; Product type e : enzyme; UDP-Gal:GlcNAc alpha-pyrophosphate-R beta 1, 3-galactosyltransferase 1052248..1053075 Escherichia coli IAI39 7153148 YP_002407008.1 CDS ECIAI39_0986 NC_011750.1 1052518 1052607 R hypothetical protein complement(1052518..1052607) Escherichia coli IAI39 7153149 YP_002407009.1 CDS manC NC_011750.1 1053072 1054496 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7677991; Product type e : enzyme; mannose-1-phosphate guanylyltransferase 1053072..1054496 Escherichia coli IAI39 7149675 YP_002407010.1 CDS cpsG NC_011750.1 1054530 1055894 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106949, 96326333, 7815923, 8759852; Product type e : enzyme; phosphomannomutase 1054530..1055894 Escherichia coli IAI39 7152009 YP_002407011.1 CDS gnd NC_011750.1 1056058 1057464 D catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 1056058..1057464 Escherichia coli IAI39 7150988 YP_002407012.1 CDS ugd NC_011750.1 1057712 1058878 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150218, 96326333; Product type e : enzyme; UDP-glucose 6-dehydrogenase 1057712..1058878 Escherichia coli IAI39 7151566 YP_002407013.1 CDS cld NC_011750.1 1059024 1060004 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98241528; Product type r : regulator; regulator of length of O-antigen component of lipopolysaccharide chains 1059024..1060004 Escherichia coli IAI39 7153080 YP_002407014.1 CDS hisI NC_011750.1 1060100 1060711 R catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein complement(1060100..1060711) Escherichia coli IAI39 7150962 YP_002407015.1 CDS hisF NC_011750.1 1060705 1061481 R catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF complement(1060705..1061481) Escherichia coli IAI39 7151653 YP_002407016.1 CDS hisA NC_011750.1 1061463 1062200 R catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase complement(1061463..1062200) Escherichia coli IAI39 7151650 YP_002407017.1 CDS hisH NC_011750.1 1062200 1062790 R with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH complement(1062200..1062790) Escherichia coli IAI39 7151646 YP_002407018.1 CDS hisB NC_011750.1 1062790 1063857 R catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase complement(1062790..1063857) Escherichia coli IAI39 7151652 YP_002407019.1 CDS hisC NC_011750.1 1063857 1064927 R catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase complement(1063857..1064927) Escherichia coli IAI39 7151647 YP_002407020.1 CDS hisD NC_011750.1 1064924 1066228 R catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase complement(1064924..1066228) Escherichia coli IAI39 7151648 YP_002407021.1 CDS hisG NC_011750.1 1066234 1067133 R long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase complement(1066234..1067133) Escherichia coli IAI39 7151649 YP_002407023.1 CDS yeeZ NC_011750.1 1067756 1068580 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative epimerase, with NAD(P)-binding Rossmann-fold domain 1067756..1068580 Escherichia coli IAI39 7151655 YP_002407024.1 CDS yeeY NC_011750.1 1068626 1069555 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1068626..1069555 Escherichia coli IAI39 7153732 YP_002407025.1 CDS yeeF NC_011750.1 1069822 1071180 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino-acid/amine transporter 1069822..1071180 Escherichia coli IAI39 7153731 YP_002407026.1 CDS yeeE NC_011750.1 1071359 1072417 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1071359..1072417 Escherichia coli IAI39 7153709 YP_002407027.1 CDS yeeD NC_011750.1 1072431 1072658 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1072431..1072658 Escherichia coli IAI39 7153708 YP_002407028.1 CDS sbcB NC_011750.1 1072701 1074128 R Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I complement(1072701..1074128) Escherichia coli IAI39 7153707 YP_002407029.1 CDS dacD NC_011750.1 1074337 1075503 D removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 1074337..1075503 Escherichia coli IAI39 7152804 YP_002407030.1 CDS ECIAI39_1007 NC_011750.1 1075630 1076850 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; putative transposase complement(1075630..1076850) Escherichia coli IAI39 7151079 YP_002407031.1 CDS ECIAI39_1008 NC_011750.1 1076869 1077387 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1076869..1077387) Escherichia coli IAI39 7149676 YP_002407032.1 CDS sbmC NC_011750.1 1077515 1077988 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11850398, 9442027, 8709849; Product type r : regulator; DNA gyrase inhibitor 1077515..1077988 Escherichia coli IAI39 7149677 YP_002407033.1 CDS yeeA NC_011750.1 1078186 1079244 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1078186..1079244 Escherichia coli IAI39 7152808 YP_002407034.1 CDS yeeX NC_011750.1 1079350 1079745 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1079350..1079745 Escherichia coli IAI39 7153706 YP_002407035.1 CDS yeeW NC_011750.1 1080643 1080837 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1080643..1080837) Escherichia coli IAI39 7153730 YP_002407036.1 CDS yeeT NC_011750.1 1081738 1081959 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1081738..1081959) Escherichia coli IAI39 7153721 YP_002407037.1 CDS yeeS NC_011750.1 1082022 1082498 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : putative factor; putative DNA repair protein; CP4-44 prophage complement(1082022..1082498) Escherichia coli IAI39 7153718 YP_002407038.1 CDS ECIAI39_1017 NC_011750.1 1082513 1082992 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7519596; Product type h : extrachromosomal origin; putative antirestriction protein of plasmid origin complement(1082513..1082992) Escherichia coli IAI39 7153715 YP_002407039.1 CDS ECIAI39_1018 NC_011750.1 1083074 1083895 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1083074..1083895) Escherichia coli IAI39 7149678 YP_002407040.1 CDS ECIAI39_1019 NC_011750.1 1084289 1084771 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1084289..1084771) Escherichia coli IAI39 7149679 YP_002407041.1 CDS ECIAI39_1020 NC_011750.1 1084913 1085029 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(1084913..1085029) Escherichia coli IAI39 7149680 YP_002407042.1 CDS ECIAI39_1021 NC_011750.1 1085216 1085440 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(1085216..1085440) Escherichia coli IAI39 7149681 YP_002407043.1 CDS ECIAI39_1022 NC_011750.1 1085430 1085822 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1085430..1085822) Escherichia coli IAI39 7149682 YP_002407044.1 CDS ECIAI39_1023 NC_011750.1 1085909 1086979 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1085909..1086979) Escherichia coli IAI39 7149683 YP_002407045.1 CDS ECIAI39_1024 NC_011750.1 1086976 1087311 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1086976..1087311) Escherichia coli IAI39 7149684 YP_002407046.1 CDS ECIAI39_1025 NC_011750.1 1087336 1087881 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1087336..1087881) Escherichia coli IAI39 7149685 YP_002407047.1 CDS ECIAI39_1026 NC_011750.1 1087878 1090274 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1087878..1090274) Escherichia coli IAI39 7149686 YP_002407048.1 CDS ECIAI39_1027 NC_011750.1 1090492 1091427 R Evidence 4 : Homologs of previously reported genes of unknown function; putative GTP-binding domain complement(1090492..1091427) Escherichia coli IAI39 7149687 YP_002407049.1 CDS ECIAI39_1028 NC_011750.1 1091449 1092627 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1091449..1092627) Escherichia coli IAI39 7149688 YP_002407051.1 CDS ECIAI39_1030 NC_011750.1 1094249 1094689 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS3 family complement(1094249..1094689) Escherichia coli IAI39 7149690 YP_002407052.1 CDS ECIAI39_1031 NC_011750.1 1094818 1096341 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9353259, 10413481; Product type e : enzyme; Group II intron-encoded reverse transcriptase/maturase complement(1094818..1096341) Escherichia coli IAI39 7150526 YP_002407053.1 CDS ECIAI39_1033 NC_011750.1 1097385 1097732 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS3 family complement(1097385..1097732) Escherichia coli IAI39 7149693 YP_002407054.1 CDS ECIAI39_1035 NC_011750.1 1098611 1099429 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 complement(1098611..1099429) Escherichia coli IAI39 7149695 YP_002407055.1 CDS insM NC_011750.1 1099465 1099767 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS600 complement(1099465..1099767) Escherichia coli IAI39 7149696 YP_002407056.1 CDS ECIAI39_1038 NC_011750.1 1100090 1101055 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1100090..1101055) Escherichia coli IAI39 7149697 YP_002407057.1 CDS ECIAI39_1039 NC_011750.1 1101109 1101867 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1101109..1101867) Escherichia coli IAI39 7149698 YP_002407058.1 CDS ECIAI39_1040 NC_011750.1 1101881 1103095 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative carbohydrate kinase complement(1101881..1103095) Escherichia coli IAI39 7149699 YP_002407059.1 CDS ECIAI39_1041 NC_011750.1 1103281 1103397 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1103281..1103397) Escherichia coli IAI39 7149700 YP_002407060.1 CDS yaiO NC_011750.1 1103876 1104607 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1103876..1104607) Escherichia coli IAI39 7149701 YP_002407061.1 CDS yaiX NC_011750.1 1104650 1105174 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleotidyl transferase complement(1104650..1105174) Escherichia coli IAI39 7153263 YP_002407062.1 CDS yaiP NC_011750.1 1105209 1106405 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated glycosyltransferase complement(1105209..1106405) Escherichia coli IAI39 7153271 YP_002407063.1 CDS yaiS NC_011750.1 1106419 1107129 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1106419..1107129) Escherichia coli IAI39 7153265 YP_002407064.1 CDS ibrA NC_011750.1 1108148 1109332 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator 1108148..1109332 Escherichia coli IAI39 7153267 YP_002407065.1 CDS ECIAI39_1047 NC_011750.1 1109516 1109842 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 1109516..1109842 Escherichia coli IAI39 7151747 YP_002407066.1 CDS ECIAI39_1048 NC_011750.1 1109839 1110729 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 1109839..1110729 Escherichia coli IAI39 7149702 YP_002407067.1 CDS ECIAI39_1050 NC_011750.1 1111646 1113820 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane receptor for iron compound or colicin complement(1111646..1113820) Escherichia coli IAI39 7151749 YP_002407068.1 CDS ECIAI39_1051 NC_011750.1 1114354 1114443 D hypothetical protein 1114354..1114443 Escherichia coli IAI39 7149704 YP_002407069.1 CDS ECIAI39_1052 NC_011750.1 1114836 1115000 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1114836..1115000 Escherichia coli IAI39 7149705 YP_002407070.1 CDS cobU NC_011750.1 1115465 1116010 D catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase 1115465..1116010 Escherichia coli IAI39 7149706 YP_002407071.1 CDS cobS NC_011750.1 1116007 1116750 D catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 1116007..1116750 Escherichia coli IAI39 7150979 YP_002407072.1 CDS cobT NC_011750.1 1116762 1117841 D catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 1116762..1117841 Escherichia coli IAI39 7150977 YP_002407073.1 CDS erfK NC_011750.1 1117906 1118838 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9298646; hypothetical protein 1117906..1118838 Escherichia coli IAI39 7150978 YP_002407074.1 CDS nac NC_011750.1 1119296 1120213 D Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator 1119296..1120213 Escherichia coli IAI39 7150623 YP_002407075.1 CDS cbl NC_011750.1 1120315 1121265 D LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl 1120315..1121265 Escherichia coli IAI39 7152164 YP_002407076.1 CDS yeeO NC_011750.1 1121386 1123026 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16042411; Product type pt : putative transporter; hypothetical protein 1121386..1123026 Escherichia coli IAI39 7150622 YP_002407077.1 CDS yeeN NC_011750.1 1123643 1124359 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1123643..1124359) Escherichia coli IAI39 7150638 YP_002407078.1 CDS amn NC_011750.1 1124702 1126156 R Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase complement(1124702..1126156) Escherichia coli IAI39 7153713 YP_002407079.1 CDS shiA NC_011750.1 1126258 1127574 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 5332864, 9524262; Product type t : transporter; shikimate transporter complement(1126258..1127574) Escherichia coli IAI39 7150728 YP_002407080.1 CDS ECIAI39_1065 NC_011750.1 1127826 1128941 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1127826..1128941 Escherichia coli IAI39 7152850 YP_002407081.1 CDS ECIAI39_1068 NC_011750.1 1131063 1131233 R hypothetical protein complement(1131063..1131233) Escherichia coli IAI39 7153712 YP_002407082.1 CDS ECIAI39_1069 NC_011750.1 1131160 1131975 R hypothetical protein complement(1131160..1131975) Escherichia coli IAI39 7149708 YP_002407083.1 CDS fyuA NC_011750.1 1132569 1134590 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7896707, 7984105; Product type rc : receptor; yersiniabactin/pesticin outer membrane receptor (IRPC) complement(1132569..1134590) Escherichia coli IAI39 7149709 YP_002407084.1 CDS irp NC_011750.1 1134721 1136298 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9818149, 11927258, 9709002; Product type e : enzyme; salicyl-AMP ligase YbtE complement(1134721..1136298) Escherichia coli IAI39 7151459 YP_002407085.1 CDS irp NC_011750.1 1136302 1137105 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative thioesterase YbtT complement(1136302..1137105) Escherichia coli IAI39 7151837 YP_002407086.1 CDS irp NC_011750.1 1137102 1138262 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11927258; Product type e : enzyme; Thiazolinyl-S-HMWP1 reductase YbtU complement(1137102..1138262) Escherichia coli IAI39 7151838 YP_002407087.1 CDS irp NC_011750.1 1138199 1147690 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15719346, 15582399, 11927258; Product type e : enzyme; High-molecular-weight nonribosomal peptide/polyketide synthetase 1 complement(1138199..1147690) Escherichia coli IAI39 7151839 YP_002407088.1 CDS irp NC_011750.1 1147778 1153903 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15719346, 15582399, 8366034, 11927258, 9709002; Product type e : enzyme; High-molecular-weight nonribosomal peptide/polyketide synthetase 2 complement(1147778..1153903) Escherichia coli IAI39 7151840 YP_002407089.1 CDS ybtA NC_011750.1 1154076 1155035 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8930916; Product type r : regulator; AraC family transcriptional regulator complement(1154076..1155035) Escherichia coli IAI39 7151841 YP_002407090.1 CDS irp NC_011750.1 1155202 1157004 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10231486, 11320115; Product type t : transporter; yersiniabactin-iron ABC transporter permease ATP-binding protein YbtP 1155202..1157004 Escherichia coli IAI39 7153392 YP_002407091.1 CDS irp NC_011750.1 1156964 1158793 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10231486, 11320115; Product type t : transporter; yersiniabactin-iron ABC transporter permease ATP-binding protein YbtQ 1156964..1158793 Escherichia coli IAI39 7151842 YP_002407092.1 CDS irp NC_011750.1 1158786 1160066 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; yersiniabactin-iron transporter permease YbtX 1158786..1160066 Escherichia coli IAI39 7151843 YP_002407093.1 CDS irp NC_011750.1 1160094 1161398 D catalyzes the conversion of chorismate to salicylate in the biosynthesis of the siderophore yersiniabactin; salicylate synthase Irp9 1160094..1161398 Escherichia coli IAI39 7151844 YP_002407094.1 CDS int NC_011750.1 1161592 1162854 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; integrase complement(1161592..1162854) Escherichia coli IAI39 7151845 YP_002407095.1 CDS yeeI NC_011750.1 1163192 1163989 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1163192..1163989) Escherichia coli IAI39 7150621 YP_002407096.1 CDS yodA NC_011750.1 1164842 1165492 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12077457, 12480884, 12909634, 9579078; hypothetical protein complement(1164842..1165492) Escherichia coli IAI39 7150552 YP_002407097.1 CDS yedZ NC_011750.1 1165750 1166385 R in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; putative sulfite oxidase subunit YedZ complement(1165750..1166385) Escherichia coli IAI39 7154450 YP_002407098.1 CDS yedY NC_011750.1 1166386 1167390 R in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; putative sulfite oxidase subunit YedY complement(1166386..1167390) Escherichia coli IAI39 7153705 YP_002407099.1 CDS yedX NC_011750.1 1167499 1167912 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1167499..1167912) Escherichia coli IAI39 7153704 YP_002407100.1 CDS yedW NC_011750.1 1168045 1168716 D induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW 1168045..1168716 Escherichia coli IAI39 7153703 YP_002407101.1 CDS yedV NC_011750.1 1168716 1170074 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15522865; Product type rc : receptor; sensory kinase in two-component regulatory system with YedW 1168716..1170074 Escherichia coli IAI39 7153702 YP_002407102.1 CDS hchA NC_011750.1 1170182 1171033 R Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA complement(1170182..1171033) Escherichia coli IAI39 7153701 YP_002407103.1 CDS ECIAI39_1091 NC_011750.1 1171629 1172756 R Evidence 2b : Function of strongly homologous gene; Product type m : membrane component; outer membrane protein N (porin) complement(1171629..1172756) Escherichia coli IAI39 7151614 YP_002407104.1 CDS ECIAI39_1092 NC_011750.1 1171955 1172179 R hypothetical protein complement(1171955..1172179) Escherichia coli IAI39 7149710 YP_002407105.1 CDS yedR NC_011750.1 1173253 1173618 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1173253..1173618 Escherichia coli IAI39 7152741 YP_002407106.1 CDS yedJ NC_011750.1 1173658 1174353 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pe : putative enzyme; hypothetical protein 1173658..1174353 Escherichia coli IAI39 7153700 YP_002407107.1 CDS dcm NC_011750.1 1174420 1175838 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90280700, 91285397, 93367813, 2198248, 2527357; Product type e : enzyme; DNA cytosine methylase 1174420..1175838 Escherichia coli IAI39 7153694 YP_002407108.1 CDS vsr NC_011750.1 1175819 1176289 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330522, 92049708, 94049122, 10360178, 10612397, 10871403, 2527357; Product type e : enzyme; DNA mismatch endonuclease of very short patch repair 1175819..1176289 Escherichia coli IAI39 7151091 YP_002407109.1 CDS yedA NC_011750.1 1176278 1177198 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1176278..1177198) Escherichia coli IAI39 7153131 YP_002407110.1 CDS yedI NC_011750.1 1177371 1178288 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1177371..1178288 Escherichia coli IAI39 7153689 YP_002407111.1 CDS yodC NC_011750.1 1178367 1178549 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1178367..1178549 Escherichia coli IAI39 7153693 YP_002407112.1 CDS ECIAI39_1100 NC_011750.1 1178611 1178799 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1178611..1178799 Escherichia coli IAI39 7154451 YP_002407113.1 CDS yedQ NC_011750.1 1178720 1180414 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16530465; Product type pe : putative enzyme; putative diguanylate cyclase 1178720..1180414 Escherichia coli IAI39 7149712 YP_002407114.1 CDS yedP NC_011750.1 1180411 1181226 R catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate; mannosyl-3-phosphoglycerate phosphatase complement(1180411..1181226) Escherichia coli IAI39 7153699 YP_002407115.1 CDS yodD NC_011750.1 1181523 1181750 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1181523..1181750) Escherichia coli IAI39 7151182 YP_002407116.1 CDS dsrB NC_011750.1 1181913 1182101 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 96324407, 7534408; hypothetical protein 1181913..1182101 Escherichia coli IAI39 7151184 YP_002407117.1 CDS rcsA NC_011750.1 1182145 1182768 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14514676, 14766922, 20167175, 90130299, 91154130, 92048476, 9882673, 7534408; Product type r : regulator; DNA-binding transcriptional activator, co-regulator with RcsB complement(1182145..1182768) Escherichia coli IAI39 7151183 YP_002407118.1 CDS fliR NC_011750.1 1183058 1183777 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1482109, 92407478, 94110225; Product type pt : putative transporter; flagellar export pore protein complement(1183058..1183777) Escherichia coli IAI39 7152577 YP_002407119.1 CDS fliQ NC_011750.1 1183852 1184121 R with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ complement(1183852..1184121) Escherichia coli IAI39 7151387 YP_002407120.1 CDS fliP NC_011750.1 1184131 1184868 R FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP complement(1184131..1184868) Escherichia coli IAI39 7151386 YP_002407121.1 CDS fliO NC_011750.1 1184868 1185233 R with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO complement(1184868..1185233) Escherichia coli IAI39 7151385 YP_002407122.1 CDS fliN NC_011750.1 1185236 1185649 R One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN complement(1185236..1185649) Escherichia coli IAI39 7151384 YP_002407123.1 CDS fliM NC_011750.1 1185646 1186650 R with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM complement(1185646..1186650) Escherichia coli IAI39 7151383 YP_002407124.1 CDS fliL NC_011750.1 1186655 1187119 R interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body-associated protein FliL complement(1186655..1187119) Escherichia coli IAI39 7151382 YP_002407125.1 CDS fliK NC_011750.1 1187224 1188351 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1482109, 8631687; Product type s : structure; flagellar hook-length control protein complement(1187224..1188351) Escherichia coli IAI39 7151381 YP_002407126.1 CDS fliJ NC_011750.1 1188348 1188791 R rod/hook and filament chaperone; flagellar biosynthesis chaperone complement(1188348..1188791) Escherichia coli IAI39 7151380 YP_002407127.1 CDS fliI NC_011750.1 1188810 1190183 R involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase complement(1188810..1190183) Escherichia coli IAI39 7151379 YP_002407128.1 CDS fliH NC_011750.1 1190183 1190869 R binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H complement(1190183..1190869) Escherichia coli IAI39 7151378 YP_002407129.1 CDS ECIAI39_1118 NC_011750.1 1191263 1191589 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 1191263..1191589 Escherichia coli IAI39 7151375 YP_002407130.1 CDS ECIAI39_1119 NC_011750.1 1191586 1192476 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 1191586..1192476 Escherichia coli IAI39 7149713 YP_002407131.1 CDS fliF NC_011750.1 1193163 1194821 R the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein complement(1193163..1194821) Escherichia coli IAI39 7151376 YP_002407132.1 CDS fliE NC_011750.1 1195036 1195350 D forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE 1195036..1195350 Escherichia coli IAI39 7151374 YP_002407133.1 CDS yedL NC_011750.1 1195755 1196234 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyltransferase complement(1195755..1196234) Escherichia coli IAI39 7151373 YP_002407134.1 CDS yedK NC_011750.1 1196345 1197013 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1196345..1197013) Escherichia coli IAI39 7153696 YP_002407135.1 CDS yedF NC_011750.1 1197122 1197355 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1197122..1197355) Escherichia coli IAI39 7153695 YP_002407136.1 CDS yedE NC_011750.1 1197352 1198557 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; putative inner membrane protein complement(1197352..1198557) Escherichia coli IAI39 7153692 YP_002407137.1 CDS yedD NC_011750.1 1198744 1199157 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1198744..1199157 Escherichia coli IAI39 7153691 YP_002407138.1 CDS amyA NC_011750.1 1199191 1200678 R converts 1,4-alpha-D-glucans to maltodextrin; cytoplasmic alpha-amylase complement(1199191..1200678) Escherichia coli IAI39 7153690 YP_002407139.1 CDS fliT NC_011750.1 1200756 1201121 R binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT complement(1200756..1201121) Escherichia coli IAI39 7150735 YP_002407140.1 CDS fliS NC_011750.1 1201121 1201531 R flagellin specific chaperone; flagellar protein FliS complement(1201121..1201531) Escherichia coli IAI39 7151389 YP_002407141.1 CDS fliD NC_011750.1 1201556 1202962 R involved in flagellin assembly; flagellar capping protein complement(1201556..1202962) Escherichia coli IAI39 7151388 YP_002407142.1 CDS fliC NC_011750.1 1203228 1204934 D structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes; flagellin 1203228..1204934 Escherichia coli IAI39 7151372 YP_002407143.1 CDS fliA NC_011750.1 1205100 1205819 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor 1205100..1205819 Escherichia coli IAI39 7151371 YP_002407144.1 CDS fliZ NC_011750.1 1205865 1206416 D expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence; flagella biosynthesis protein FliZ 1205865..1206416 Escherichia coli IAI39 7151370 YP_002407145.1 CDS fliY NC_011750.1 1206504 1207304 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96125225, 8450713, 8774726, 9298646, 9740056; Product type t : transporter; cystine transporter subunit 1206504..1207304 Escherichia coli IAI39 7151391 YP_002407146.1 CDS yedO NC_011750.1 1207409 1208395 D catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase 1207409..1208395 Escherichia coli IAI39 7151390 YP_002407147.1 CDS yecS NC_011750.1 1208410 1209078 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter permease 1208410..1209078 Escherichia coli IAI39 7153697 YP_002407148.1 CDS yecC NC_011750.1 1209075 1209827 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative amino-acid ABC transporter ATP-binding protein YecC 1209075..1209827 Escherichia coli IAI39 7153688 YP_002407149.1 CDS sdiA NC_011750.1 1210057 1210779 D regulates genes involved in cell division; DNA-binding transcriptional activator SdiA 1210057..1210779 Escherichia coli IAI39 7153675 YP_002407150.1 CDS yecF NC_011750.1 1210847 1211071 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3515318, 7567469; hypothetical protein complement(1210847..1211071) Escherichia coli IAI39 7152817 YP_002407151.1 CDS uvrY NC_011750.1 1211530 1212186 D in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator 1211530..1212186 Escherichia coli IAI39 7153678 YP_002407152.1 CDS uvrC NC_011750.1 1212183 1214015 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1212183..1214015 Escherichia coli IAI39 7153117 YP_002407153.1 CDS pgsA NC_011750.1 1214072 1214620 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 381294, 7007311, 94253011, 1323047, 3003065, 8917447; Product type e : enzyme; phosphatidylglycerophosphate synthetase 1214072..1214620 Escherichia coli IAI39 7153115 YP_002407154.1 CDS yecA NC_011750.1 1215270 1215935 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1215270..1215935 Escherichia coli IAI39 7150555 YP_002407155.1 CDS tyrP NC_011750.1 1215985 1217196 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89008121, 2022620; Product type t : transporter; tyrosine transporter complement(1215985..1217196) Escherichia coli IAI39 7153674 YP_002407156.1 CDS yecH NC_011750.1 1217387 1217626 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1217387..1217626 Escherichia coli IAI39 7153064 YP_002407157.1 CDS ftn NC_011750.1 1217664 1218161 R cytoplasmic iron storage protein; ferritin complement(1217664..1218161) Escherichia coli IAI39 7153680 YP_002407158.1 CDS yecR NC_011750.1 1218333 1218656 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1218333..1218656) Escherichia coli IAI39 7151432 YP_002407159.1 CDS ECIAI39_1149 NC_011750.1 1218863 1219009 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1218863..1219009) Escherichia coli IAI39 7153687 YP_002407160.1 CDS yecJ NC_011750.1 1219120 1219371 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1219120..1219371 Escherichia coli IAI39 7151860 YP_002407161.1 CDS yecI NC_011750.1 1219450 1219953 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative ferritin-like protein complement(1219450..1219953) Escherichia coli IAI39 7153682 YP_002407162.1 CDS araF NC_011750.1 1220750 1221739 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89255061, 90375534, 2445996, 326784, 326785, 6885805, 7031057, 9298646; Product type t : transporter; L-arabinose ABC transporter subunit periplasmic-binding protein 1220750..1221739 Escherichia coli IAI39 7153681 YP_002407163.1 CDS araG NC_011750.1 1221809 1223323 D Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein 1221809..1223323 Escherichia coli IAI39 7150752 YP_002407164.1 CDS araH NC_011750.1 1223335 1224324 D Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter permease 1223335..1224324 Escherichia coli IAI39 7150753 YP_002407165.1 CDS otsB NC_011750.1 1224491 1225291 D biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase 1224491..1225291 Escherichia coli IAI39 7150754 YP_002407166.1 CDS otsA NC_011750.1 1225266 1226690 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92078100, 92121128, 93302496, 8045430; Product type e : enzyme; trehalose-6-phosphate synthase 1225266..1226690 Escherichia coli IAI39 7152313 YP_002407167.1 CDS yecG NC_011750.1 1226697 1227125 R ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspC complement(1226697..1227125) Escherichia coli IAI39 7152312 YP_002407168.1 CDS flhD NC_011750.1 1227896 1228255 D with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD 1227896..1228255 Escherichia coli IAI39 7153679 YP_002407169.1 CDS motA NC_011750.1 1228963 1229850 D With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA 1228963..1229850 Escherichia coli IAI39 7151367 YP_002407170.1 CDS motB NC_011750.1 1229847 1230773 D with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB 1229847..1230773 Escherichia coli IAI39 7152111 YP_002407171.1 CDS cheA NC_011750.1 1230778 1232742 D chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA 1230778..1232742 Escherichia coli IAI39 7152112 YP_002407172.1 CDS cheW NC_011750.1 1232763 1233266 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91126073, 91296802, 91317710, 2002011, 3510184; Product type r : regulator; purine-binding chemotaxis protein 1232763..1233266 Escherichia coli IAI39 7150934 YP_002407173.1 CDS tar NC_011750.1 1233411 1235072 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90094243, 92165727, 6305515, 9315712; Product type r : regulator; methyl-accepting chemotaxis protein II 1233411..1235072 Escherichia coli IAI39 7150887 YP_002407174.1 CDS cheR NC_011750.1 1235363 1236223 D methylates the MCP; chemotaxis methyltransferase CheR 1235363..1236223 Escherichia coli IAI39 7152941 YP_002407175.1 CDS cheB NC_011750.1 1236226 1237275 D regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase 1236226..1237275 Escherichia coli IAI39 7150936 YP_002407176.1 CDS cheY NC_011750.1 1237290 1237679 D chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY 1237290..1237679 Escherichia coli IAI39 7150935 YP_002407177.1 CDS cheZ NC_011750.1 1237690 1238334 D cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis regulator CheZ 1237690..1238334 Escherichia coli IAI39 7150938 YP_002407178.1 CDS flhB NC_011750.1 1238543 1239691 D membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB 1238543..1239691 Escherichia coli IAI39 7150939 YP_002407179.1 CDS flhA NC_011750.1 1239684 1241762 D membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA 1239684..1241762 Escherichia coli IAI39 7151365 YP_002407180.1 CDS flhE NC_011750.1 1241762 1242154 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8002587, 1482109, 89181349; hypothetical protein 1241762..1242154 Escherichia coli IAI39 7151364 YP_002407181.1 CDS argS NC_011750.1 1242207 1243940 R catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase complement(1242207..1243940) Escherichia coli IAI39 7151369 YP_002407182.1 CDS yecM NC_011750.1 1244156 1244722 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12660999; Product type pe : putative enzyme; hypothetical protein 1244156..1244722 Escherichia coli IAI39 7150772 YP_002407183.1 CDS cutC NC_011750.1 1244736 1245482 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95362641, 7635807; Product type t : transporter; copper homeostasis protein CutC 1244736..1245482 Escherichia coli IAI39 7153683 YP_002407184.1 CDS torY NC_011750.1 1245869 1246969 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461225, 8919859; Product type c : carrier; TMAO reductase III (TorYZ), cytochrome c-type subunit 1245869..1246969 Escherichia coli IAI39 7151035 YP_002407185.1 CDS torZ NC_011750.1 1246994 1249423 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97077292, 11004177; Product type e : enzyme; trimethylamine N-oxide reductase system III, catalytic subunit 1246994..1249423 Escherichia coli IAI39 7153010 YP_002407186.1 CDS yecP NC_011750.1 1249458 1250429 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1249458..1250429) Escherichia coli IAI39 7153011 YP_002407187.1 CDS yecO NC_011750.1 1250426 1251169 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11746687; Product type e : enzyme; AdoMet-dependent methyltransferase complement(1250426..1251169) Escherichia coli IAI39 7153686 YP_002407188.1 CDS yecN NC_011750.1 1251210 1251605 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1251210..1251605) Escherichia coli IAI39 7153685 YP_002407189.1 CDS yecE NC_011750.1 1251658 1252476 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2129559, 7984428; hypothetical protein complement(1251658..1252476) Escherichia coli IAI39 7153684 YP_002407190.1 CDS yecD NC_011750.1 1252473 1253039 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(1252473..1253039) Escherichia coli IAI39 7153677 YP_002407191.1 CDS aspS NC_011750.1 1253349 1255121 D catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1253349..1255121 Escherichia coli IAI39 7153676 YP_002407192.1 CDS ntpA NC_011750.1 1255123 1255566 D converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 1255123..1255566 Escherichia coli IAI39 7150808 YP_002407193.1 CDS yebC NC_011750.1 1255595 1256335 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1255595..1256335 Escherichia coli IAI39 7152262 YP_002407194.1 CDS ruvC NC_011750.1 1256370 1256891 D endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 1256370..1256891 Escherichia coli IAI39 7153658 YP_002407195.1 CDS yebB NC_011750.1 1256893 1257495 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1256893..1257495) Escherichia coli IAI39 7152775 YP_002407196.1 CDS ruvA NC_011750.1 1257770 1258381 D plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 1257770..1258381 Escherichia coli IAI39 7153657 YP_002407197.1 CDS ruvB NC_011750.1 1258390 1259400 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1258390..1259400 Escherichia coli IAI39 7152773 YP_002407198.1 CDS znuB NC_011750.1 1259548 1260333 R involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane component complement(1259548..1260333) Escherichia coli IAI39 7152774 YP_002407199.1 CDS znuC NC_011750.1 1260330 1261085 R involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase complement(1260330..1261085) Escherichia coli IAI39 7154593 YP_002407200.1 CDS znuA NC_011750.1 1261164 1262096 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic component 1261164..1262096 Escherichia coli IAI39 7154594 YP_002407201.1 CDS yebA NC_011750.1 1262112 1263434 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1732206; Product type pe : putative enzyme; hypothetical protein 1262112..1263434 Escherichia coli IAI39 7154592 YP_002407202.1 CDS lpxM NC_011750.1 1263553 1264524 D Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 1263553..1264524 Escherichia coli IAI39 7153656 YP_002407203.1 CDS pykA NC_011750.1 1264656 1266098 R catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase complement(1264656..1266098) Escherichia coli IAI39 7151972 YP_002407204.1 CDS yebK NC_011750.1 1266226 1267095 R Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR complement(1266226..1267095) Escherichia coli IAI39 7152546 YP_002407205.1 CDS ECIAI39_1197 NC_011750.1 1267264 1267416 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1267264..1267416 Escherichia coli IAI39 7153662 YP_002407206.1 CDS zwf NC_011750.1 1267432 1268907 D catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1267432..1268907 Escherichia coli IAI39 7149716 YP_002407207.1 CDS edd NC_011750.1 1269142 1270953 D catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 1269142..1270953 Escherichia coli IAI39 7154600 YP_002407208.1 CDS eda NC_011750.1 1270990 1271631 D catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 1270990..1271631 Escherichia coli IAI39 7151203 YP_002407209.1 CDS purT NC_011750.1 1271687 1272865 R non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 complement(1271687..1272865) Escherichia coli IAI39 7151202 YP_002407210.1 CDS yebG NC_011750.1 1272999 1273289 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9368369, 99403401; Product type cp : cell process; DNA damage-inducible protein YebG 1272999..1273289 Escherichia coli IAI39 7152535 YP_002407211.1 CDS yebF NC_011750.1 1273344 1273712 D secreted protein; unknown function; hypothetical protein 1273344..1273712 Escherichia coli IAI39 7153661 YP_002407212.1 CDS yebE NC_011750.1 1274038 1274697 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1274038..1274697 Escherichia coli IAI39 7153660 YP_002407213.1 CDS ptrB NC_011750.1 1274904 1276964 D PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 1274904..1276964 Escherichia coli IAI39 7153659 YP_002407214.1 CDS exoX NC_011750.1 1276961 1277623 R 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X complement(1276961..1277623) Escherichia coli IAI39 7152516 YP_002407215.1 CDS yobB NC_011750.1 1277647 1278303 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1277647..1278303) Escherichia coli IAI39 7151260 YP_002407216.1 CDS holE NC_011750.1 1278405 1278635 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15090519, 92147649, 92156151, 94131961, 1575709, 8341603, 8505306; Product type e : enzyme; DNA polymerase III subunit theta complement(1278405..1278635) Escherichia coli IAI39 7154446 YP_002407217.1 CDS yobA NC_011750.1 1278774 1279148 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1278774..1279148 Escherichia coli IAI39 7151671 YP_002407218.1 CDS yebZ NC_011750.1 1279152 1280024 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1279152..1280024 Escherichia coli IAI39 7154445 YP_002407219.1 CDS yebY NC_011750.1 1280037 1280378 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1280037..1280378 Escherichia coli IAI39 7153673 YP_002407220.1 CDS pphA NC_011750.1 1280772 1281428 D Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins; serine/threonine protein phosphatase 1 1280772..1281428 Escherichia coli IAI39 7152781 YP_002407221.1 CDS yebW NC_011750.1 1281429 1281704 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1281429..1281704) Escherichia coli IAI39 7152458 YP_002407222.1 CDS yebV NC_011750.1 1281725 1281961 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1281725..1281961) Escherichia coli IAI39 7153671 YP_002407223.1 CDS yebU NC_011750.1 1282079 1283518 R in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF complement(1282079..1283518) Escherichia coli IAI39 7153670 YP_002407224.1 CDS yebT NC_011750.1 1283598 1286231 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1283598..1286231) Escherichia coli IAI39 7153669 YP_002407225.1 CDS yebS NC_011750.1 1286200 1287483 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1286200..1287483) Escherichia coli IAI39 7153668 YP_002407226.1 CDS yebR NC_011750.1 1287559 1288110 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1287559..1288110 Escherichia coli IAI39 7153667 YP_002407227.1 CDS proQ NC_011750.1 1288207 1288905 D affects solute and DNA transport through an unknown mechanism; putative solute/DNA competence effector 1288207..1288905 Escherichia coli IAI39 7153666 YP_002407228.1 CDS prc NC_011750.1 1288925 1290973 D Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 1288925..1290973 Escherichia coli IAI39 7152487 YP_002407229.1 CDS htpX NC_011750.1 1291165 1292046 D putative metalloprotease; heat shock protein HtpX 1291165..1292046 Escherichia coli IAI39 7152471 YP_002407230.1 CDS yebQ NC_011750.1 1292092 1293465 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter complement(1292092..1293465) Escherichia coli IAI39 7151687 YP_002407231.1 CDS kdgR NC_011750.1 1293642 1294433 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659677, 4359651; Product type r : regulator; DNA-binding transcriptional repressor KdgR 1293642..1294433 Escherichia coli IAI39 7153665 YP_002407232.1 CDS yobH NC_011750.1 1294577 1294816 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1294577..1294816) Escherichia coli IAI39 7151878 YP_002407233.1 CDS yebO NC_011750.1 1295193 1295480 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1295193..1295480 Escherichia coli IAI39 7154449 YP_002407234.1 CDS ECIAI39_1226 NC_011750.1 1295982 1296188 R hypothetical protein complement(1295982..1296188) Escherichia coli IAI39 7153664 YP_002407235.1 CDS yobF NC_011750.1 1296150 1296293 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1296150..1296293 Escherichia coli IAI39 7149717 YP_002407236.1 CDS ECIAI39_1228 NC_011750.1 1296264 1296848 R hypothetical protein complement(1296264..1296848) Escherichia coli IAI39 7154448 YP_002407237.1 CDS cspC NC_011750.1 1296306 1296515 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20345064, 21101802, 94293754, 12071744, 7984109, 8022261, 9298646, 9868784, 9921691; Product type f : factor; cold shock-like protein CspC 1296306..1296515 Escherichia coli IAI39 7149718 YP_002407238.1 CDS rrmA NC_011750.1 1296681 1297490 D methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase A 1296681..1297490 Escherichia coli IAI39 7151014 YP_002407239.1 CDS yebN NC_011750.1 1297487 1298053 R membrane protein YebN; hypothetical protein complement(1297487..1298053) Escherichia coli IAI39 7152735 YP_002407240.1 CDS yobD NC_011750.1 1298482 1298940 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1298482..1298940) Escherichia coli IAI39 7150527 YP_002407241.1 CDS manZ NC_011750.1 1298995 1299855 R hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID complement(1298995..1299855) Escherichia coli IAI39 7154447 YP_002407242.1 CDS manY NC_011750.1 1299859 1300659 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10473571, 87165962, 90036983, 94086520, 97128775, 7811395, 8774730; Product type t : transporter; PTS system mannose-specific protein subunit IIC complement(1299859..1300659) Escherichia coli IAI39 7152012 YP_002407243.1 CDS manX NC_011750.1 1300722 1301693 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87165962, 90036983, 8131846, 8676384, 9074635, 9298646; Product type t : transporter; PTS system manniose-specific transporter subunit IIAB complement(1300722..1301693) Escherichia coli IAI39 7152011 YP_002407244.1 CDS yoaE NC_011750.1 1302156 1303712 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative membrane protein fused with conserved domain 1302156..1303712 Escherichia coli IAI39 7152010 YP_002407245.1 CDS adrB NC_011750.1 1303716 1305314 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16513732; Product type pe : putative enzyme; putative cyclic di-GMP phosphodiesterase complement(1303716..1305314) Escherichia coli IAI39 7154440 YP_002407246.1 CDS sdaA NC_011750.1 1305445 1306809 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15155761, 89359152, 91056090, 93170282; Product type e : enzyme; L-serine deaminase I complement(1305445..1306809) Escherichia coli IAI39 7150693 YP_002407247.1 CDS yeaB NC_011750.1 1306993 1307571 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pe : putative enzyme; hypothetical protein complement(1306993..1307571) Escherichia coli IAI39 7152810 YP_002407248.1 CDS pabB NC_011750.1 1307575 1308936 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88025006, 91067712, 91302313, 96011382, 6330050, 7896119; Product type e : enzyme; aminodeoxychorismate synthase subunit I complement(1307575..1308936) Escherichia coli IAI39 7153632 YP_002407249.1 CDS yoaH NC_011750.1 1309010 1309189 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1309010..1309189 Escherichia coli IAI39 7152320 YP_002407250.1 CDS yoaC NC_011750.1 1309309 1309668 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1309309..1309668) Escherichia coli IAI39 7154443 YP_002407251.1 CDS ECIAI39_1243 NC_011750.1 1309859 1309954 D hypothetical protein 1309859..1309954 Escherichia coli IAI39 7154439 YP_002407252.1 CDS yoaB NC_011750.1 1310030 1310374 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1310030..1310374) Escherichia coli IAI39 7149719 YP_002407253.1 CDS yoaA NC_011750.1 1310506 1312416 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-dependent helicase 1310506..1312416 Escherichia coli IAI39 7154438 YP_002407254.1 CDS yeaZ NC_011750.1 1312474 1313169 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 1312474..1313169 Escherichia coli IAI39 7154437 YP_002407255.1 CDS yeaY NC_011750.1 1313208 1313789 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16079137; Product type lp : lipoprotein; putative outer membrane-associated lipoprotein 1313208..1313789 Escherichia coli IAI39 7153655 YP_002407256.1 CDS fadD NC_011750.1 1313994 1315679 D Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1313994..1315679 Escherichia coli IAI39 7153654 YP_002407257.1 CDS rnd NC_011750.1 1315749 1316876 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88289400, 89053950, 93015723, 8107670; Product type e : enzyme; ribonuclease D 1315749..1316876 Escherichia coli IAI39 7151274 YP_002407258.1 CDS yeaX NC_011750.1 1316923 1317888 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dioxygenase subunit complement(1316923..1317888) Escherichia coli IAI39 7152655 YP_002407259.1 CDS yeaW NC_011750.1 1317944 1319068 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 2Fe-2S cluster-containing dioxygenase subunit complement(1317944..1319068) Escherichia coli IAI39 7153653 YP_002407260.1 CDS yeaV NC_011750.1 1319100 1320545 R member of the betaine, carnitine, choline transporter (BCCT) family; unknown function; putative transporter complement(1319100..1320545) Escherichia coli IAI39 7153652 YP_002407261.1 CDS yeaU NC_011750.1 1320961 1322046 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative tartrate dehydrogenase complement(1320961..1322046) Escherichia coli IAI39 7153651 YP_002407262.1 CDS yeaT NC_011750.1 1322149 1323072 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1322149..1323072 Escherichia coli IAI39 7153650 YP_002407263.1 CDS yeaS NC_011750.1 1323199 1323837 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; leucine export protein LeuE 1323199..1323837 Escherichia coli IAI39 7153649 YP_002407264.1 CDS yeaR NC_011750.1 1324010 1324369 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1324010..1324369 Escherichia coli IAI39 7153648 YP_002407265.1 CDS yoaG NC_011750.1 1324373 1324555 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1324373..1324555 Escherichia coli IAI39 7153647 YP_002407266.1 CDS yeaQ NC_011750.1 1324703 1324951 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1324703..1324951 Escherichia coli IAI39 7154442 YP_002407267.1 CDS yeaP NC_011750.1 1325218 1326243 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase complement(1325218..1326243) Escherichia coli IAI39 7153646 YP_002407268.1 CDS yoaF NC_011750.1 1326426 1326680 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1326426..1326680 Escherichia coli IAI39 7153645 YP_002407269.1 CDS yeaO NC_011750.1 1326702 1327049 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1326702..1327049) Escherichia coli IAI39 7154441 YP_002407270.1 CDS yeaN NC_011750.1 1327104 1328285 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter complement(1327104..1328285) Escherichia coli IAI39 7153644 YP_002407271.1 CDS yeaM NC_011750.1 1328382 1329203 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1328382..1329203 Escherichia coli IAI39 7153643 YP_002407272.1 CDS yeaL NC_011750.1 1329160 1329606 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1329160..1329606) Escherichia coli IAI39 7153642 YP_002407273.1 CDS yoaI NC_011750.1 1329776 1329880 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1329776..1329880 Escherichia coli IAI39 7153641 YP_002407274.1 CDS yeaK NC_011750.1 1329881 1330384 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1329881..1330384) Escherichia coli IAI39 7154444 YP_002407275.1 CDS yeaJ NC_011750.1 1330427 1331917 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase complement(1330427..1331917) Escherichia coli IAI39 7153640 YP_002407276.1 CDS yeaI NC_011750.1 1332098 1333573 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase complement(1332098..1333573) Escherichia coli IAI39 7153639 YP_002407277.1 CDS yeaH NC_011750.1 1333720 1335003 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1333720..1335003) Escherichia coli IAI39 7153638 YP_002407278.1 CDS yeaG NC_011750.1 1335116 1337050 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1335116..1337050) Escherichia coli IAI39 7153637 YP_002407279.1 CDS mipA NC_011750.1 1337486 1338232 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10037771, 20267815; Product type f : factor; scaffolding protein for murein synthesizing machinery 1337486..1338232 Escherichia coli IAI39 7153636 YP_002407280.1 CDS yeaE NC_011750.1 1338322 1339176 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1338322..1339176 Escherichia coli IAI39 7152087 YP_002407281.1 CDS yeaD NC_011750.1 1339227 1340111 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1339227..1340111) Escherichia coli IAI39 7153635 YP_002407282.1 CDS gapA NC_011750.1 1340195 1341190 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 775311, 94131963, 98361923, 1862091, 2124629, 2990926, 7896119, 8636984, 9298646; Product type e : enzyme; glyceraldehyde-3-phosphate dehydrogenase A complement(1340195..1341190) Escherichia coli IAI39 7153634 YP_002407283.1 CDS msrB NC_011750.1 1341532 1341945 D this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 1341532..1341945 Escherichia coli IAI39 7151480 YP_002407284.1 CDS yeaC NC_011750.1 1341987 1342259 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1341987..1342259 Escherichia coli IAI39 7152135 YP_002407285.1 CDS ydjL NC_011750.1 1342629 1343705 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1342629..1343705 Escherichia coli IAI39 7153633 YP_002407286.1 CDS ydjK NC_011750.1 1343732 1345111 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1343732..1345111 Escherichia coli IAI39 7153623 YP_002407287.1 CDS ydjJ NC_011750.1 1345128 1346171 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12897001; Product type pe : putative enzyme; putative iditol dehydrogenase 1345128..1346171 Escherichia coli IAI39 7153622 YP_002407288.1 CDS ydjI NC_011750.1 1346192 1347028 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldolase 1346192..1347028 Escherichia coli IAI39 7153621 YP_002407289.1 CDS ydjH NC_011750.1 1347033 1347980 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar kinase 1347033..1347980 Escherichia coli IAI39 7153620 YP_002407290.1 CDS ydjG NC_011750.1 1347990 1348970 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1347990..1348970 Escherichia coli IAI39 7153619 YP_002407291.1 CDS ydjF NC_011750.1 1349107 1349865 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1349107..1349865 Escherichia coli IAI39 7153618 YP_002407292.1 CDS insB NC_011750.1 1350107 1350610 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS1 complement(1350107..1350610) Escherichia coli IAI39 7153617 YP_002407293.1 CDS insA NC_011750.1 1350529 1350804 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA complement(1350529..1350804) Escherichia coli IAI39 7151795 YP_002407294.1 CDS ydjE NC_011750.1 1350866 1352116 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter 1350866..1352116 Escherichia coli IAI39 7151784 YP_002407295.1 CDS pncA NC_011750.1 1352209 1352850 R catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase complement(1352209..1352850) Escherichia coli IAI39 7153616 YP_002407296.1 CDS ansA NC_011750.1 1352861 1353877 R converts asparagine to aspartate and ammonia; cytoplasmic asparaginase I complement(1352861..1353877) Escherichia coli IAI39 7152433 YP_002407297.1 CDS sppA NC_011750.1 1354044 1355900 R SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 complement(1354044..1355900) Escherichia coli IAI39 7150737 YP_002407298.1 CDS ydjA NC_011750.1 1356061 1356612 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 1356061..1356612 Escherichia coli IAI39 7152888 YP_002407299.1 CDS ECIAI39_1291 NC_011750.1 1356638 1356787 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1356638..1356787 Escherichia coli IAI39 7153615 YP_002407300.1 CDS selD NC_011750.1 1356729 1357772 D catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 1356729..1357772 Escherichia coli IAI39 7149720 YP_002407301.1 CDS topB NC_011750.1 1357720 1359732 D decatenates replicating daughter chromosomes; DNA topoisomerase III 1357720..1359732 Escherichia coli IAI39 7152828 YP_002407302.1 CDS gdhA NC_011750.1 1359809 1361152 R converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase complement(1359809..1361152) Escherichia coli IAI39 7153003 YP_002407303.1 CDS nudG NC_011750.1 1361626 1362033 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101911; Product type e : enzyme; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase complement(1361626..1362033) Escherichia coli IAI39 7151501 YP_002407304.1 CDS ynjF NC_011750.1 1362120 1362740 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type m : membrane component; putative phosphatidyl transferase, inner membrane protein 1362120..1362740 Escherichia coli IAI39 7152267 YP_002407305.1 CDS ynjE NC_011750.1 1362749 1364056 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported thiosulfate sulfur transferase / thiosulfate binding protein complement(1362749..1364056) Escherichia coli IAI39 7154436 YP_002407306.1 CDS ynjD NC_011750.1 1364123 1364776 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sulfate/thiosulfate ABC transporter ATP-binding protein complement(1364123..1364776) Escherichia coli IAI39 7154435 YP_002407307.1 CDS ynjC NC_011750.1 1364776 1366266 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; ABC transporter membrane protein complement(1364776..1366266) Escherichia coli IAI39 7154434 YP_002407308.1 CDS ynjB NC_011750.1 1366284 1367450 R Evidence 4 : Homologs of previously reported genes of unknown function; putative ABC transporter solute-binding protein complement(1366284..1367450) Escherichia coli IAI39 7154433 YP_002407309.1 CDS ynjA NC_011750.1 1367460 1368008 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1367460..1368008) Escherichia coli IAI39 7154432 YP_002407310.1 CDS ydjZ NC_011750.1 1368008 1368715 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1368008..1368715) Escherichia coli IAI39 7154431 YP_002407311.1 CDS ydjY NC_011750.1 1368730 1369407 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1368730..1369407) Escherichia coli IAI39 7153631 YP_002407312.1 CDS ydjX NC_011750.1 1369412 1370122 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1369412..1370122) Escherichia coli IAI39 7153630 YP_002407313.1 CDS xthA NC_011750.1 1370289 1371095 R removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III complement(1370289..1371095) Escherichia coli IAI39 7153629 YP_002407314.1 CDS astC NC_011750.1 1371541 1372761 D catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate; bifunctional succinylornithine transaminase/acetylornithine transaminase 1371541..1372761 Escherichia coli IAI39 7153184 YP_002407315.1 CDS astA NC_011750.1 1372758 1373792 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14675764, 98361920; Product type e : enzyme; arginine succinyltransferase 1372758..1373792 Escherichia coli IAI39 7150812 YP_002407316.1 CDS astD NC_011750.1 1373789 1375267 D a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase 1373789..1375267 Escherichia coli IAI39 7150810 YP_002407317.1 CDS astB NC_011750.1 1375264 1376607 D catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation; succinylarginine dihydrolase 1375264..1376607 Escherichia coli IAI39 7150813 YP_002407318.1 CDS astE NC_011750.1 1376600 1377568 D catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase 1376600..1377568 Escherichia coli IAI39 7150811 YP_002407319.1 CDS spy NC_011750.1 1377898 1378383 D periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; periplasmic protein 1377898..1378383 Escherichia coli IAI39 7150814 YP_002407320.1 CDS ydjR NC_011750.1 1378586 1379161 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21862596; hypothetical protein 1378586..1379161 Escherichia coli IAI39 7152891 YP_002407321.1 CDS ydjQ NC_011750.1 1379121 1380008 R 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease complement(1379121..1380008) Escherichia coli IAI39 7153628 YP_002407322.1 CDS nadE NC_011750.1 1380238 1381065 R catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(1380238..1381065) Escherichia coli IAI39 7153627 YP_002407323.1 CDS osmE NC_011750.1 1381267 1381605 D osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE 1381267..1381605 Escherichia coli IAI39 7152169 YP_002407324.1 CDS chbB NC_011750.1 1381904 1382224 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB 1381904..1382224 Escherichia coli IAI39 7152310 YP_002407325.1 CDS chbC NC_011750.1 1382309 1383667 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC 1382309..1383667 Escherichia coli IAI39 7150929 YP_002407326.1 CDS chbA NC_011750.1 1383718 1384068 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA 1383718..1384068 Escherichia coli IAI39 7150930 YP_002407327.1 CDS chbR NC_011750.1 1384076 1384918 D represses the celABCDF-ydjC operon involved in carbon uptake; DNA-binding transcriptional regulator ChbR 1384076..1384918 Escherichia coli IAI39 7150928 YP_002407328.1 CDS chbF NC_011750.1 1385022 1386374 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20042356, 90185127, 9405618; Product type e : enzyme; cryptic phospho-beta-glucosidase, NAD(P)-binding 1385022..1386374 Escherichia coli IAI39 7150933 YP_002407329.1 CDS chbG NC_011750.1 1386387 1387136 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 20042356, 1987146, 2179047, 8121401, 9405618; hypothetical protein 1386387..1387136 Escherichia coli IAI39 7150931 YP_002407330.1 CDS katE NC_011750.1 1387183 1389444 R Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II complement(1387183..1389444) Escherichia coli IAI39 7150932 YP_002407331.1 CDS cedA NC_011750.1 1389627 1389890 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9427399; Product type cp : cell process; cell division modulator 1389627..1389890 Escherichia coli IAI39 7151871 YP_002407332.1 CDS ydjO NC_011750.1 1390167 1390982 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1390167..1390982 Escherichia coli IAI39 7150923 YP_002407333.1 CDS ydjN NC_011750.1 1390986 1392377 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative cation-acid symporter complement(1390986..1392377) Escherichia coli IAI39 7153626 YP_002407334.1 CDS ydjM NC_011750.1 1392510 1393100 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10760155; Product type pm : putative membrane component; hypothetical protein complement(1392510..1393100) Escherichia coli IAI39 7153625 YP_002407335.1 CDS yniC NC_011750.1 1393263 1393931 R YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase complement(1393263..1393931) Escherichia coli IAI39 7153624 YP_002407336.1 CDS yniB NC_011750.1 1394078 1394614 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1394078..1394614 Escherichia coli IAI39 7154430 YP_002407337.1 CDS yniA NC_011750.1 1394655 1395515 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase/kinase complement(1394655..1395515) Escherichia coli IAI39 7154429 YP_002407338.1 CDS ydiZ NC_011750.1 1395621 1395911 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1395621..1395911) Escherichia coli IAI39 7154428 YP_002407339.1 CDS pfkB NC_011750.1 1396012 1396941 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 78194149, 88292964, 6235149, 6310120; Product type e : enzyme; 6-phosphofructokinase 2 complement(1396012..1396941) Escherichia coli IAI39 7153614 YP_002407340.1 CDS ydiY NC_011750.1 1397228 1397986 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1397228..1397986 Escherichia coli IAI39 7152371 YP_002407341.1 CDS ECIAI39_1333 NC_011750.1 1398039 1398257 R hypothetical protein complement(1398039..1398257) Escherichia coli IAI39 7153613 YP_002407342.1 CDS ECIAI39_1334 NC_011750.1 1398313 1400211 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative ankyrin repeat regulatory protein complement(1398313..1400211) Escherichia coli IAI39 7149721 YP_002407343.1 CDS thrS NC_011750.1 1400734 1402662 D catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 1400734..1402662 Escherichia coli IAI39 7149722 YP_002407344.1 CDS rpmI NC_011750.1 1403305 1403502 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93085722, 10094780, 3298224, 3542048, 6325158; Product type s : structure; 50S ribosomal protein L35 1403305..1403502 Escherichia coli IAI39 7151779 YP_002407345.1 CDS rplT NC_011750.1 1403556 1403912 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1403556..1403912 Escherichia coli IAI39 7152702 YP_002407347.1 CDS pheS NC_011750.1 1404218 1405201 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1404218..1405201 Escherichia coli IAI39 7152390 YP_002407348.1 CDS pheT NC_011750.1 1405216 1407603 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1405216..1407603 Escherichia coli IAI39 7152392 YP_002407349.1 CDS ihfA NC_011750.1 1407608 1407907 D This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 1407608..1407907 Escherichia coli IAI39 7152393 YP_002407350.1 CDS btuC NC_011750.1 1408008 1408988 D with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease 1408008..1408988 Escherichia coli IAI39 7151760 YP_002407351.1 CDS btuE NC_011750.1 1409051 1409602 D similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; putative glutathione peroxidase 1409051..1409602 Escherichia coli IAI39 7150879 YP_002407352.1 CDS btuD NC_011750.1 1409602 1410351 D ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase 1409602..1410351 Escherichia coli IAI39 7150881 YP_002407353.1 CDS nlpC NC_011750.1 1410429 1410893 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12620121; Product type lp : lipoprotein; putative peptidase lipoprotein 1410429..1410893 Escherichia coli IAI39 7150880 YP_002407354.1 CDS ydiV NC_011750.1 1411140 1411853 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1411140..1411853 Escherichia coli IAI39 7152235 YP_002407355.1 CDS ydiU NC_011750.1 1411916 1413352 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1411916..1413352 Escherichia coli IAI39 7153612 YP_002407356.1 CDS ydiE NC_011750.1 1413356 1413547 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15039350; hypothetical protein complement(1413356..1413547) Escherichia coli IAI39 7153611 YP_002407357.1 CDS aroH NC_011750.1 1413679 1414725 R tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase complement(1413679..1414725) Escherichia coli IAI39 7153595 YP_002407358.1 CDS ydiA NC_011750.1 1414882 1415715 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1414882..1415715) Escherichia coli IAI39 7150782 YP_002407359.1 CDS pps NC_011750.1 1416047 1418425 D catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase 1416047..1418425 Escherichia coli IAI39 7153592 YP_002407360.1 CDS ECIAI39_1352 NC_011750.1 1418908 1420314 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative dicarboxylate transporter 1418908..1420314 Escherichia coli IAI39 7152466 YP_002407361.1 CDS ECIAI39_1353 NC_011750.1 1420350 1421309 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 2-hydroxyacid dehydrogenase/reductase 1420350..1421309 Escherichia coli IAI39 7149723 YP_002407362.1 CDS ECIAI39_1354 NC_011750.1 1421320 1421799 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1421320..1421799 Escherichia coli IAI39 7149724 YP_002407363.1 CDS ECIAI39_1355 NC_011750.1 1421812 1422555 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10800688; Product type pe : putative enzyme; putative short-chain dehydrogenase/reductase 1421812..1422555 Escherichia coli IAI39 7149725 YP_002407364.1 CDS ydiD NC_011750.1 1422606 1424300 R acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids; short chain acyl-CoA synthetase complement(1422606..1424300) Escherichia coli IAI39 7149726 YP_002407365.1 CDS ydiT NC_011750.1 1424303 1424596 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S ferredoxin-type oxidoreductase subunit complement(1424303..1424596) Escherichia coli IAI39 7153594 YP_002407366.1 CDS ydiS NC_011750.1 1424593 1425882 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; hypothetical protein complement(1424593..1425882) Escherichia coli IAI39 7153610 YP_002407367.1 CDS ydiR NC_011750.1 1425937 1426875 R May play a role in a redox process; electron transfer flavoprotein subunit YdiR complement(1425937..1426875) Escherichia coli IAI39 7153609 YP_002407368.1 CDS ydiQ NC_011750.1 1426895 1427659 R YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; putative electron transfer flavoprotein YdiQ complement(1426895..1427659) Escherichia coli IAI39 7153608 YP_002407369.1 CDS ydiP NC_011750.1 1427975 1428886 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1427975..1428886 Escherichia coli IAI39 7153607 YP_002407370.1 CDS ydiF NC_011750.1 1430062 1431657 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16253988; Product type e : enzyme; short chain acyl-CoA transferase subunit alpha/beta complement(1430062..1431657) Escherichia coli IAI39 7153605 YP_002407371.1 CDS aroD NC_011750.1 1431803 1432561 R catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase complement(1431803..1432561) Escherichia coli IAI39 7153596 YP_002407372.1 CDS ydiB NC_011750.1 1432592 1433458 R YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase complement(1432592..1433458) Escherichia coli IAI39 7150778 YP_002407373.1 CDS ydiN NC_011750.1 1433470 1434735 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(1433470..1434735) Escherichia coli IAI39 7153593 YP_002407374.1 CDS ydiM NC_011750.1 1434962 1436176 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter complement(1434962..1436176) Escherichia coli IAI39 7153603 YP_002407375.1 CDS ydiL NC_011750.1 1436276 1436632 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1436276..1436632) Escherichia coli IAI39 7153602 YP_002407376.1 CDS ydiK NC_011750.1 1437061 1438173 R YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; putative inner membrane protein complement(1437061..1438173) Escherichia coli IAI39 7152712 YP_002407377.1 CDS ydiJ NC_011750.1 1438560 1441616 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11102686; Product type pe : putative enzyme; putative FAD-linked oxidoreductase 1438560..1441616 Escherichia coli IAI39 7153600 YP_002407378.1 CDS ydiI NC_011750.1 1441613 1442023 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : putative enzyme; hypothetical protein 1441613..1442023 Escherichia coli IAI39 7153599 YP_002407379.1 CDS ydiH NC_011750.1 1442042 1442311 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1442042..1442311 Escherichia coli IAI39 7153598 YP_002407380.1 CDS sufA NC_011750.1 1442860 1443228 D functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein 1442860..1443228 Escherichia coli IAI39 7152779 YP_002407381.1 CDS sufB NC_011750.1 1443237 1444724 D with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB 1443237..1444724 Escherichia coli IAI39 7152922 YP_002407382.1 CDS sufC NC_011750.1 1444734 1445480 D part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase ATPase 1444734..1445480 Escherichia coli IAI39 7152923 YP_002407383.1 CDS sufD NC_011750.1 1445455 1446726 D with SufBC activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufD 1445455..1446726 Escherichia coli IAI39 7152924 YP_002407384.1 CDS sufS NC_011750.1 1446723 1447943 D catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase 1446723..1447943 Escherichia coli IAI39 7152925 YP_002407385.1 CDS sufE NC_011750.1 1447956 1448372 D Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE 1447956..1448372 Escherichia coli IAI39 7152928 YP_002407386.1 CDS ynhG NC_011750.1 1448521 1449525 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1448521..1449525 Escherichia coli IAI39 7152926 YP_002407387.1 CDS lpp NC_011750.1 1449588 1449824 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 334727, 338599, 322142, 353292, 391404, 4261992, 4575979, 6765942; Product type lp : lipoprotein; murein lipoprotein complement(1449588..1449824) Escherichia coli IAI39 7154427 YP_002407388.1 CDS pykF NC_011750.1 1450135 1451547 R catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase complement(1450135..1451547) Escherichia coli IAI39 7151962 YP_002407389.1 CDS ydhZ NC_011750.1 1452104 1452313 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1452104..1452313 Escherichia coli IAI39 7152547 YP_002407390.1 CDS ydhY NC_011750.1 1452770 1453396 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; hypothetical protein 1452770..1453396 Escherichia coli IAI39 7153591 YP_002407391.1 CDS ydhV NC_011750.1 1453417 1455519 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1453417..1455519 Escherichia coli IAI39 7153590 YP_002407392.1 CDS ydhW NC_011750.1 1455523 1456170 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1455523..1456170 Escherichia coli IAI39 7153588 YP_002407393.1 CDS ydhU NC_011750.1 1456899 1457684 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative cytochrome b subunit of a reductase 1456899..1457684 Escherichia coli IAI39 7153589 YP_002407394.1 CDS ydhT NC_011750.1 1457688 1458500 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1457688..1458500 Escherichia coli IAI39 7153587 YP_002407395.1 CDS ydhS NC_011750.1 1458512 1460116 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1458512..1460116) Escherichia coli IAI39 7153586 YP_002407396.1 CDS ydhR NC_011750.1 1460242 1460547 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1460242..1460547) Escherichia coli IAI39 7153585 YP_002407397.1 CDS ydhQ NC_011750.1 1461121 1462377 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1461121..1462377 Escherichia coli IAI39 7150619 YP_002407398.1 CDS mdtK NC_011750.1 1462418 1463791 R NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein complement(1462418..1463791) Escherichia coli IAI39 7153583 YP_002407399.1 CDS ribC NC_011750.1 1464006 1464647 D catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1464006..1464647 Escherichia coli IAI39 7152038 YP_002407400.1 CDS cfa NC_011750.1 1464687 1465835 R catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane fatty acyl phospholipid synthase complement(1464687..1465835) Escherichia coli IAI39 7152627 YP_002407401.1 CDS ydhC NC_011750.1 1466126 1467337 R uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC complement(1466126..1467337) Escherichia coli IAI39 7150924 YP_002407402.1 CDS ydhB NC_011750.1 1467450 1468382 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2404765; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1467450..1468382 Escherichia coli IAI39 7153574 YP_002407403.1 CDS purR NC_011750.1 1468379 1469404 R binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR complement(1468379..1469404) Escherichia coli IAI39 7153573 YP_002407404.1 CDS ydhP NC_011750.1 1469958 1471127 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative efflux protein; MFS family 1469958..1471127 Escherichia coli IAI39 7152534 YP_002407405.1 CDS sodB NC_011750.1 1471273 1471854 R SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase complement(1471273..1471854) Escherichia coli IAI39 7153582 YP_002407406.1 CDS ydhO NC_011750.1 1471982 1472809 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported hydrolase complement(1471982..1472809) Escherichia coli IAI39 7152871 YP_002407407.1 CDS ydhD NC_011750.1 1473144 1473491 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15833738, 15840565, 11950925, 12730244; Product type e : enzyme; hypothetical protein 1473144..1473491 Escherichia coli IAI39 7153581 YP_002407408.1 CDS lhr NC_011750.1 1473542 1478158 R similar to the DNA and RNA helicase superfamily II and eukaryotic DEAD family of helicases; longest known protein in E. coli; putative ATP-dependent helicase Lhr complement(1473542..1478158) Escherichia coli IAI39 7153575 YP_002407409.1 CDS rnt NC_011750.1 1478251 1478898 R Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T complement(1478251..1478898) Escherichia coli IAI39 7151934 YP_002407410.1 CDS gloA NC_011750.1 1479001 1479408 R Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I complement(1479001..1479408) Escherichia coli IAI39 7152663 YP_002407411.1 CDS nemA NC_011750.1 1479489 1480586 R FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase complement(1479489..1480586) Escherichia coli IAI39 7151534 YP_002407412.1 CDS ydhM NC_011750.1 1480623 1481138 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1480623..1481138) Escherichia coli IAI39 7152205 YP_002407413.1 CDS ydhF NC_011750.1 1481613 1482509 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1481613..1482509 Escherichia coli IAI39 7153580 YP_002407414.1 CDS sodC NC_011750.1 1482589 1483110 D SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase 1482589..1483110 Escherichia coli IAI39 7153576 YP_002407415.1 CDS ydhK NC_011750.1 1483111 1485123 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1483111..1485123) Escherichia coli IAI39 7152872 YP_002407416.1 CDS ydhJ NC_011750.1 1485123 1485980 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12900028; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase complement(1485123..1485980) Escherichia coli IAI39 7153579 YP_002407417.1 CDS ydhI NC_011750.1 1485983 1486219 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1485983..1486219) Escherichia coli IAI39 7153578 YP_002407418.1 CDS slyA NC_011750.1 1486420 1486854 D Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA 1486420..1486854 Escherichia coli IAI39 7153577 YP_002407419.1 CDS slyB NC_011750.1 1486901 1487368 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8544813; Product type lp : lipoprotein; putative outer membrane lipoprotein complement(1486901..1487368) Escherichia coli IAI39 7152860 YP_002407420.1 CDS anmK NC_011750.1 1487642 1488751 D catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 1487642..1488751 Escherichia coli IAI39 7152861 YP_002407421.1 CDS ydhA NC_011750.1 1488849 1489178 D MliC; membrane-bound lysozyme inhibitor of c-type lysozyme; lysozyme inhibitor 1488849..1489178 Escherichia coli IAI39 7150736 YP_002407422.1 CDS pdxH NC_011750.1 1489237 1489893 D catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 1489237..1489893 Escherichia coli IAI39 7153572 YP_002407423.1 CDS tyrS NC_011750.1 1490022 1491296 D catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1490022..1491296 Escherichia coli IAI39 7152357 YP_002407424.1 CDS pdxY NC_011750.1 1491355 1492218 D catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 1491355..1492218 Escherichia coli IAI39 7153066 YP_002407425.1 CDS gst NC_011750.1 1492262 1492867 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95096109, 2185038, 9680481; Product type e : enzyme; glutathionine S-transferase complement(1492262..1492867) Escherichia coli IAI39 7152360 YP_002407426.1 CDS tppB NC_011750.1 1492973 1494475 R mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; putative tripeptide transporter permease complement(1492973..1494475) Escherichia coli IAI39 7151595 YP_002407427.1 CDS ECIAI39_1422 NC_011750.1 1494758 1494958 R hypothetical protein complement(1494758..1494958) Escherichia coli IAI39 7153570 YP_002407428.1 CDS nth NC_011750.1 1495086 1495721 R DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III complement(1495086..1495721) Escherichia coli IAI39 7149727 YP_002407429.1 CDS rsxE NC_011750.1 1495721 1496416 R in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex RsxE subunit complement(1495721..1496416) Escherichia coli IAI39 7152261 YP_002407430.1 CDS rsxG NC_011750.1 1496420 1497040 R part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG complement(1496420..1497040) Escherichia coli IAI39 7152756 YP_002407431.1 CDS rnfD NC_011750.1 1497044 1498102 R RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD complement(1497044..1498102) Escherichia coli IAI39 7152757 YP_002407432.1 CDS rsxC NC_011750.1 1498103 1500325 R part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC complement(1498103..1500325) Escherichia coli IAI39 7152755 YP_002407433.1 CDS rsxB NC_011750.1 1500318 1500896 R part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB complement(1500318..1500896) Escherichia coli IAI39 7152754 YP_002407434.1 CDS rsxA NC_011750.1 1500896 1501477 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411911, 10637328, 12773378; Product type pm : putative membrane component; Na(+)-translocating NADH-quinone reductase subunit E complement(1500896..1501477) Escherichia coli IAI39 7152753 YP_002407435.1 CDS ydgK NC_011750.1 1501554 1501994 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1501554..1501994) Escherichia coli IAI39 7152752 YP_002407436.1 CDS ydgT NC_011750.1 1502080 1502295 R YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein complement(1502080..1502295) Escherichia coli IAI39 7153569 YP_002407437.1 CDS blr NC_011750.1 1502568 1502768 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20392465, 10931331; Product type m : membrane component; beta-lactam resistance membrane protein complement(1502568..1502768) Escherichia coli IAI39 7153571 YP_002407438.1 CDS ydgJ NC_011750.1 1502936 1503976 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1502936..1503976 Escherichia coli IAI39 7150872 YP_002407439.1 CDS add NC_011750.1 1504012 1505013 R catalyzes the formation of inosine from adenosine; adenosine deaminase complement(1504012..1505013) Escherichia coli IAI39 7153568 YP_002407440.1 CDS malY NC_011750.1 1505117 1506289 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20164451, 7665481, 91310596; Product type e : enzyme; bifunctional beta-cystathionase, PLP-dependent and regulator of maltose regulon complement(1505117..1506289) Escherichia coli IAI39 7150683 YP_002407441.1 CDS malX NC_011750.1 1506299 1507891 R phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional PTS system maltose and glucose-specific transporter subunits IICB complement(1506299..1507891) Escherichia coli IAI39 7152006 YP_002407442.1 CDS malI NC_011750.1 1508066 1509094 D regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI 1508066..1509094 Escherichia coli IAI39 7152005 YP_002407443.1 CDS insG NC_011750.1 1509236 1510582 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element 1509236..1510582 Escherichia coli IAI39 7151998 YP_002407444.1 CDS hdhA NC_011750.1 1510644 1511411 D Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase 1510644..1511411 Escherichia coli IAI39 7151809 YP_002407445.1 CDS uidR NC_011750.1 1511632 1512222 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88038341, 2823062, 3934044, 11115104; Product type r : regulator; DNA-binding transcriptional repressor 1511632..1512222 Escherichia coli IAI39 7151622 YP_002407446.1 CDS uidA NC_011750.1 1512614 1514425 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87041472, 88038341, 2103475, 8125312; Product type e : enzyme; beta-D-glucuronidase 1512614..1514425 Escherichia coli IAI39 7153093 YP_002407447.1 CDS uidB NC_011750.1 1514422 1515795 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3534890; Product type t : transporter; glucuronide transporter 1514422..1515795 Escherichia coli IAI39 7153090 YP_002407448.1 CDS uidC NC_011750.1 1515834 1517099 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15774881; Product type t : transporter; putative outer membrane porin protein 1515834..1517099 Escherichia coli IAI39 7153091 YP_002407449.1 CDS ydgA NC_011750.1 1517144 1518652 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1517144..1518652) Escherichia coli IAI39 7153092 YP_002407450.1 CDS manA NC_011750.1 1518753 1519928 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82100097, 6397402; Product type e : enzyme; mannose-6-phosphate isomerase complement(1518753..1519928) Escherichia coli IAI39 7153562 YP_002407451.1 CDS fumA NC_011750.1 1520127 1521773 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88193096, 88268900, 92011457, 3005475, 6328431, 9298646; Product type e : enzyme; fumarate hydratase 1520127..1521773 Escherichia coli IAI39 7152008 YP_002407452.1 CDS fumC NC_011750.1 1521916 1523319 D class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1521916..1523319 Escherichia coli IAI39 7151453 YP_002407453.1 CDS tus NC_011750.1 1523316 1524245 R binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein complement(1523316..1524245) Escherichia coli IAI39 7151455 YP_002407454.1 CDS rstB NC_011750.1 1524321 1525622 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93086426, 1495392, 1925016, 2646639; Product type r : regulator; sensor protein RstB complement(1524321..1525622) Escherichia coli IAI39 7153056 YP_002407455.1 CDS rstA NC_011750.1 1525626 1526354 R response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA complement(1525626..1526354) Escherichia coli IAI39 7152750 YP_002407456.1 CDS ydgC NC_011750.1 1526474 1526809 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1526474..1526809 Escherichia coli IAI39 7152749 YP_002407457.1 CDS folM NC_011750.1 1526806 1527528 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14617668; Product type e : enzyme; short chain dehydrogenase complement(1526806..1527528) Escherichia coli IAI39 7153563 YP_002407458.1 CDS ydgI NC_011750.1 1527565 1528947 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1311296; Product type pt : putative transporter; putative arginine/ornithine antiporter transporter complement(1527565..1528947) Escherichia coli IAI39 7151403 YP_002407459.1 CDS ydgH NC_011750.1 1529133 1530077 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1529133..1530077) Escherichia coli IAI39 7153567 YP_002407460.1 CDS pntA NC_011750.1 1530602 1532134 D forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 1530602..1532134 Escherichia coli IAI39 7153566 YP_002407461.1 CDS pntB NC_011750.1 1532145 1533533 D catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 1532145..1533533 Escherichia coli IAI39 7152436 YP_002407462.1 CDS tqsA NC_011750.1 1533558 1534592 R transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; putative transport protein complement(1533558..1534592) Escherichia coli IAI39 7152437 YP_002407463.1 CDS mdtJ NC_011750.1 1535004 1535369 D with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ 1535004..1535369 Escherichia coli IAI39 7153565 YP_002407464.1 CDS mdtI NC_011750.1 1535356 1535685 D with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI 1535356..1535685 Escherichia coli IAI39 7152037 YP_002407465.1 CDS ydgD NC_011750.1 1535724 1536545 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative exported metallopeptidase complement(1535724..1536545) Escherichia coli IAI39 7152036 YP_002407466.1 CDS asr NC_011750.1 1536821 1537129 R required for growth and survival under moderately acid conditions; acid shock protein complement(1536821..1537129) Escherichia coli IAI39 7153564 YP_002407467.1 CDS ynfM NC_011750.1 1537553 1538806 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS superfamily transporter complement(1537553..1538806) Escherichia coli IAI39 7150809 YP_002407468.1 CDS ynfL NC_011750.1 1538913 1539806 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1538913..1539806 Escherichia coli IAI39 7154426 YP_002407469.1 CDS dgsA NC_011750.1 1539941 1541161 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10318813, 20490366, 6989798, 99340206, 99395104, 99398866, 7766024; Product type r : regulator; DNA-binding transcriptional repressor 1539941..1541161 Escherichia coli IAI39 7154425 YP_002407470.1 CDS ynfK NC_011750.1 1541286 1541981 D DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; putative dithiobiotin synthetase 1541286..1541981 Escherichia coli IAI39 7151131 YP_002407471.1 CDS clcB NC_011750.1 1541934 1543190 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12384697; Product type pt : putative transporter; putative voltage-gated ClC-type chloride channel ClcB complement(1541934..1543190) Escherichia coli IAI39 7154424 YP_002407472.1 CDS dmsD NC_011750.1 1543384 1543998 R binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD complement(1543384..1543998) Escherichia coli IAI39 7150961 YP_002407473.1 CDS ynfH NC_011750.1 1544041 1544895 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type m : membrane component; oxidoreductase, membrane subunit complement(1544041..1544895) Escherichia coli IAI39 7151152 YP_002407474.1 CDS ynfG NC_011750.1 1544897 1545514 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type c : carrier; oxidoreductase, Fe-S subunit complement(1544897..1545514) Escherichia coli IAI39 7154423 YP_002407475.1 CDS ynfF NC_011750.1 1545525 1547948 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type e : enzyme; oxidoreductase subunit complement(1545525..1547948) Escherichia coli IAI39 7154422 YP_002407476.1 CDS ynfE NC_011750.1 1548009 1550435 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type e : enzyme; oxidoreductase subunit complement(1548009..1550435) Escherichia coli IAI39 7154421 YP_002407477.1 CDS ynfD NC_011750.1 1550634 1550939 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9868784; hypothetical protein complement(1550634..1550939) Escherichia coli IAI39 7154420 YP_002407478.1 CDS ynfC NC_011750.1 1551047 1551757 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1551047..1551757 Escherichia coli IAI39 7154419 YP_002407479.1 CDS speG NC_011750.1 1551760 1552320 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94357898; Product type e : enzyme; spermidine N1-acetyltransferase complement(1551760..1552320) Escherichia coli IAI39 7154418 YP_002407480.1 CDS ynfB NC_011750.1 1552355 1552696 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1552355..1552696) Escherichia coli IAI39 7152885 YP_002407481.1 CDS ynfA NC_011750.1 1552831 1553157 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1552831..1553157 Escherichia coli IAI39 7154417 YP_002407482.1 CDS rspA NC_011750.1 1553363 1554577 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 93341455, 94310441; Product type pe : putative enzyme; putative enolase/dehydratase 1553363..1554577 Escherichia coli IAI39 7154416 YP_002407483.1 CDS rspB NC_011750.1 1554589 1555608 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7545940; Product type pe : putative enzyme; putative dehydrogenase 1554589..1555608 Escherichia coli IAI39 7152745 YP_002407484.1 CDS intQ NC_011750.1 1555796 1557091 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative defective integrase; Qin prophage complement(1555796..1557091) Escherichia coli IAI39 7152746 YP_002407485.1 CDS ECIAI39_1482 NC_011750.1 1558080 1558406 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 1558080..1558406 Escherichia coli IAI39 7149728 YP_002407486.1 CDS ECIAI39_1483 NC_011750.1 1558403 1558885 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 1558403..1558885 Escherichia coli IAI39 7149729 YP_002407487.1 CDS ECIAI39_1484 NC_011750.1 1559477 1561000 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9353259, 10413481; Product type e : enzyme; Group II intron-encoded reverse transcriptase/maturase 1559477..1561000 Escherichia coli IAI39 7149730 YP_002407488.1 CDS ECIAI39_1485 NC_011750.1 1561117 1561563 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 1561117..1561563 Escherichia coli IAI39 7150528 YP_002407489.1 CDS ydfX NC_011750.1 1561623 1562036 D Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; hypothetical protein 1561623..1562036 Escherichia coli IAI39 7149732 YP_002407490.1 CDS ECIAI39_1487 NC_011750.1 1561963 1562982 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1561963..1562982 Escherichia coli IAI39 7153560 YP_002407491.1 CDS ECIAI39_1488 NC_011750.1 1563023 1563445 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1563023..1563445 Escherichia coli IAI39 7149733 YP_002407492.1 CDS ECIAI39_1489 NC_011750.1 1563442 1563798 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1563442..1563798 Escherichia coli IAI39 7149734 YP_002407493.1 CDS ECIAI39_1490 NC_011750.1 1564221 1564346 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1564221..1564346 Escherichia coli IAI39 7149735 YP_002407494.1 CDS ECIAI39_1491 NC_011750.1 1565105 1565287 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1565105..1565287) Escherichia coli IAI39 7149736 YP_002407495.1 CDS ECIAI39_1492 NC_011750.1 1565465 1566688 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1565465..1566688 Escherichia coli IAI39 7149737 YP_002407496.1 CDS insM NC_011750.1 1566750 1567052 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS600 1566750..1567052 Escherichia coli IAI39 7149738 YP_002407497.1 CDS ECIAI39_1494 NC_011750.1 1567088 1567906 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 1567088..1567906 Escherichia coli IAI39 7151825 YP_002407498.1 CDS ECIAI39_1495 NC_011750.1 1567812 1568465 D hypothetical protein 1567812..1568465 Escherichia coli IAI39 7149739 YP_002407499.1 CDS ECIAI39_1496 NC_011750.1 1568509 1569291 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase/IS protein complement(1568509..1569291) Escherichia coli IAI39 7149740 YP_002407500.1 CDS ECIAI39_1497 NC_011750.1 1569288 1570310 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS100 complement(1569288..1570310) Escherichia coli IAI39 7149741 YP_002407501.1 CDS cspF NC_011750.1 1571069 1571281 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9484881, 8022261, 9439003; Product type h : extrachromosomal origin; cold shock protein; Qin prophage complement(1571069..1571281) Escherichia coli IAI39 7153558 YP_002407502.1 CDS cspB NC_011750.1 1571582 1571797 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293754, 94293756, 9439003; Product type h : extrachromosomal origin; cold shock protein; Qin prophage 1571582..1571797 Escherichia coli IAI39 7151017 YP_002407503.1 CDS essQ NC_011750.1 1572551 1572766 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative S lysis protein; Qin prophage 1572551..1572766 Escherichia coli IAI39 7151013 YP_002407504.1 CDS ydfR NC_011750.1 1572771 1573082 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1572771..1573082 Escherichia coli IAI39 7151241 YP_002407505.1 CDS ydfQ NC_011750.1 1573079 1573612 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated lysozyme; Qin prophage 1573079..1573612 Escherichia coli IAI39 7153557 YP_002407506.1 CDS ydfP NC_011750.1 1573609 1574106 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1573609..1574106 Escherichia coli IAI39 7153556 YP_002407507.1 CDS cspI NC_011750.1 1574469 1574681 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9484881; Product type h : extrachromosomal origin; cold shock protein; Qin prophage 1574469..1574681 Escherichia coli IAI39 7153555 YP_002407508.1 CDS gnsB NC_011750.1 1575355 1575528 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21429224; Product type h : extrachromosomal origin; hypothetical protein 1575355..1575528 Escherichia coli IAI39 7151020 YP_002407509.1 CDS ydfO NC_011750.1 1575680 1576090 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1575680..1576090) Escherichia coli IAI39 7151568 YP_002407510.1 CDS nohB NC_011750.1 1576770 1577315 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92334985; Product type h : extrachromosomal origin; DNA packaging protein; DLP12 prophage 1576770..1577315 Escherichia coli IAI39 7153554 YP_002407511.1 CDS A NC_011750.1 1577290 1579215 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; terminase large subunit from bacteriophage origin 1577290..1579215 Escherichia coli IAI39 7152239 YP_002407512.1 CDS W NC_011750.1 1579212 1579418 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11302702; Product type h : extrachromosomal origin; head-to-tail joining protein W (gpW) from bacteriophage origin 1579212..1579418 Escherichia coli IAI39 7150639 YP_002407513.1 CDS B NC_011750.1 1579415 1581016 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin; Portal protein B (minor capsid protein B) from bacteriophage origin 1579415..1581016 Escherichia coli IAI39 7153132 YP_002407514.1 CDS C NC_011750.1 1580862 1582328 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin; minor capsid protein C from bacteriophage origin 1580862..1582328 Escherichia coli IAI39 7150832 YP_002407515.1 CDS D NC_011750.1 1582338 1582670 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6233140; Product type h : extrachromosomal origin; head decoration protein (major capsid protein D) from bacteriophage origin 1582338..1582670 Escherichia coli IAI39 7150884 YP_002407516.1 CDS ECIAI39_1514 NC_011750.1 1582726 1583751 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin; major head protein 1582726..1583751 Escherichia coli IAI39 7151074 YP_002407517.1 CDS fI NC_011750.1 1583754 1584116 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; DNA packaging protein from bacteriophage origin 1583754..1584116 Escherichia coli IAI39 7149743 YP_002407518.1 CDS ECIAI39_1516 NC_011750.1 1584109 1584549 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS3 family complement(1584109..1584549) Escherichia coli IAI39 7151322 YP_002407519.1 CDS ECIAI39_1517 NC_011750.1 1584678 1586201 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9353259, 10413481; Product type e : enzyme; Group II intron-encoded reverse transcriptase/maturase complement(1584678..1586201) Escherichia coli IAI39 7150529 YP_002407520.1 CDS ECIAI39_1518 NC_011750.1 1586793 1587275 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 complement(1586793..1587275) Escherichia coli IAI39 7149745 YP_002407521.1 CDS ECIAI39_1519 NC_011750.1 1587272 1587598 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 complement(1587272..1587598) Escherichia coli IAI39 7149746 YP_002407522.1 CDS cvrA NC_011750.1 1589112 1590848 R the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter complement(1589112..1590848) Escherichia coli IAI39 7151836 YP_002407523.1 CDS ldcA NC_011750.1 1590943 1591857 R catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A complement(1590943..1591857) Escherichia coli IAI39 7151037 YP_002407524.1 CDS emtA NC_011750.1 1591957 1592568 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98317285; Product type e : enzyme; lytic murein endotransglycosylase E 1591957..1592568 Escherichia coli IAI39 7151917 YP_002407525.1 CDS ycgR NC_011750.1 1592570 1593304 R Evidence 2b : Function of strongly homologous gene; PubMedId : 11031114; Product type cp : cell process; flagellar function protein complement(1592570..1593304) Escherichia coli IAI39 7151219 YP_002407526.1 CDS ymgE NC_011750.1 1593505 1593759 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative inner membrane protein with transglycosylase-associated domain 1593505..1593759 Escherichia coli IAI39 7153471 YP_002407527.1 CDS prrA NC_011750.1 1593809 1595800 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative outer membrane receptor complement(1593809..1595800) Escherichia coli IAI39 7154397 YP_002407528.1 CDS modD NC_011750.1 1595805 1596659 R involved in molybdenum transport; molybdenum transport protein ModD complement(1595805..1596659) Escherichia coli IAI39 7152498 YP_002407529.1 CDS ECIAI39_1529 NC_011750.1 1596656 1597468 R Evidence 4 : Homologs of previously reported genes of unknown function; putative SAM-dependent methyltransferase complement(1596656..1597468) Escherichia coli IAI39 7152105 YP_002407530.1 CDS ECIAI39_1530 NC_011750.1 1597478 1598236 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ABC transporter ATP-binding protein complement(1597478..1598236) Escherichia coli IAI39 7149748 YP_002407531.1 CDS ECIAI39_1531 NC_011750.1 1598233 1599213 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative ABC transporter permease complement(1598233..1599213) Escherichia coli IAI39 7149749 YP_002407532.1 CDS ECIAI39_1532 NC_011750.1 1599213 1600277 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter periplasmic binding protein complement(1599213..1600277) Escherichia coli IAI39 7149750 YP_002407533.1 CDS treA NC_011750.1 1600565 1602262 R periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell; trehalase complement(1600565..1602262) Escherichia coli IAI39 7149751 YP_002407534.1 CDS dhaH NC_011750.1 1602582 1604000 R phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL; dihydroxyacetone kinase subunit M complement(1602582..1604000) Escherichia coli IAI39 7153017 YP_002407535.1 CDS dhaL NC_011750.1 1604011 1604643 R with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL complement(1604011..1604643) Escherichia coli IAI39 7151133 YP_002407536.1 CDS dhaK NC_011750.1 1604654 1605724 R with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK complement(1604654..1605724) Escherichia coli IAI39 7151135 YP_002407537.1 CDS dhaR NC_011750.1 1605952 1607871 D Positively regulates the dhaKLM operon from a sigma-70 promoter; DNA-binding transcriptional regulator DhaR 1605952..1607871 Escherichia coli IAI39 7151134 YP_002407538.1 CDS ECIAI39_1538 NC_011750.1 1607908 1608138 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1607908..1608138) Escherichia coli IAI39 7151136 YP_002407539.1 CDS ychF NC_011750.1 1608276 1609367 R translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD complement(1608276..1609367) Escherichia coli IAI39 7149752 YP_002407540.1 CDS pth NC_011750.1 1609484 1610068 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(1609484..1610068) Escherichia coli IAI39 7153476 YP_002407541.1 CDS ychH NC_011750.1 1610346 1610624 D YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 1610346..1610624 Escherichia coli IAI39 7152514 YP_002407542.1 CDS ychM NC_011750.1 1610679 1612358 R putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; putative sulfate transporter YchM complement(1610679..1612358) Escherichia coli IAI39 7153477 YP_002407543.1 CDS prsA NC_011750.1 1612483 1613430 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(1612483..1613430) Escherichia coli IAI39 7153479 YP_002407544.1 CDS ipk NC_011750.1 1613581 1614432 R An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase complement(1613581..1614432) Escherichia coli IAI39 7152499 YP_002407545.1 CDS lolB NC_011750.1 1614432 1615055 R Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB complement(1614432..1615055) Escherichia coli IAI39 7151854 YP_002407546.1 CDS hemA NC_011750.1 1615269 1616525 D catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1615269..1616525 Escherichia coli IAI39 7151951 YP_002407547.1 CDS prfA NC_011750.1 1616567 1617649 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1616567..1617649 Escherichia coli IAI39 7151624 YP_002407548.1 CDS prmC NC_011750.1 1617649 1618482 D HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1617649..1618482 Escherichia coli IAI39 7152472 YP_002407549.1 CDS ychQ NC_011750.1 1618479 1618871 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10322010; Product type pr : putative regulator; putative transcriptional regulator 1618479..1618871 Escherichia coli IAI39 7152482 YP_002407550.1 CDS ychA NC_011750.1 1618875 1619684 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10322010; Product type pr : putative regulator; putative transcriptional regulator 1618875..1619684 Escherichia coli IAI39 7153482 YP_002407551.1 CDS kdsA NC_011750.1 1619720 1620574 D catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1619720..1620574 Escherichia coli IAI39 7153474 YP_002407552.1 CDS ldrB NC_011750.1 1620723 1620830 R Evidence 1b : Function experimentally demonstrated in the studied species; Product type f : factor; toxic polypeptide, small complement(1620723..1620830) Escherichia coli IAI39 7151885 YP_002407553.1 CDS ldrB NC_011750.1 1621258 1621425 R Evidence 2b : Function of strongly homologous gene; Product type f : factor; small toxic polypeptide complement(1621258..1621425) Escherichia coli IAI39 7152583 YP_002407554.1 CDS chaA NC_011750.1 1621771 1622871 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93266586, 94193576, 94292460; Product type t : transporter; calcium/sodium:proton antiporter complement(1621771..1622871) Escherichia coli IAI39 7152584 YP_002407555.1 CDS chaB NC_011750.1 1623141 1623371 D in Escherichia coli this protein putatively regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1623141..1623371 Escherichia coli IAI39 7150925 YP_002407556.1 CDS chaC NC_011750.1 1623508 1624224 D Evidence 1b : Function experimentally demonstrated in the studied species; Product type r : regulator; regulatory protein for cation transport 1623508..1624224 Escherichia coli IAI39 7150926 YP_002407557.1 CDS ychN NC_011750.1 1624268 1624621 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1624268..1624621) Escherichia coli IAI39 7150927 YP_002407558.1 CDS ychP NC_011750.1 1624947 1626200 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pf : putative factor; hypothetical protein 1624947..1626200 Escherichia coli IAI39 7153480 YP_002407559.1 CDS narL NC_011750.1 1626201 1626851 R two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL complement(1626201..1626851) Escherichia coli IAI39 7153481 YP_002407560.1 CDS narX NC_011750.1 1626844 1628640 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92276349, 92374842, 94083940, 2649492, 2657652, 2668029; Product type r : regulator; nitrate/nitrite sensor protein NarX complement(1626844..1628640) Escherichia coli IAI39 7152193 YP_002407561.1 CDS ECIAI39_1561 NC_011750.1 1628666 1628884 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1628666..1628884 Escherichia coli IAI39 7152199 YP_002407562.1 CDS narK NC_011750.1 1628979 1630370 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91258310, 2657652, 2668029; Product type t : transporter; nitrate/nitrite transporter 1628979..1630370 Escherichia coli IAI39 7149753 YP_002407563.1 CDS narG NC_011750.1 1630764 1634507 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 74167294, 89384449, 92121125, 2233673, 2668029, 2995309, 3053688, 3308846, 6094247; Product type e : enzyme; nitrate reductase 1 subunit alpha 1630764..1634507 Escherichia coli IAI39 7152192 YP_002407564.1 CDS narH NC_011750.1 1634504 1636042 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 74167294, 89384449, 92121125, 1321049, 2832376, 3053688, 8383531, 8388253, 8664273, 9516445; Product type c : carrier; nitrate reductase 1, beta (Fe-S) subunit 1634504..1636042 Escherichia coli IAI39 7152188 YP_002407565.1 CDS narJ NC_011750.1 1636039 1636749 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89384449, 92121125, 9632249, 2832376; Product type f : factor; nitrate reductase 1 minormolybdenum-cofactor-assembly chaperone 1636039..1636749 Escherichia coli IAI39 7152189 YP_002407566.1 CDS narI NC_011750.1 1636749 1637426 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 75114694, 89384449, 92121125, 2832376, 3053688; Product type c : carrier; nitrate reductase 1, gamma (cytochrome b(NR)) subunit 1636749..1637426 Escherichia coli IAI39 7152191 YP_002407567.1 CDS purU NC_011750.1 1637972 1638814 R produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase complement(1637972..1638814) Escherichia coli IAI39 7150616 YP_002407568.1 CDS ychJ NC_011750.1 1638864 1639322 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1638864..1639322) Escherichia coli IAI39 7152536 YP_002407569.1 CDS rssA NC_011750.1 1639396 1640340 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 1639396..1640340 Escherichia coli IAI39 7153478 YP_002407570.1 CDS rssB NC_011750.1 1640432 1641445 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339606, 12912910, 9495753; Product type r : regulator; response regulator of RpoS 1640432..1641445 Escherichia coli IAI39 7152747 YP_002407571.1 CDS galU NC_011750.1 1641647 1642555 D together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP--glucose-1-phosphate uridylyltransferase subunit GalU 1641647..1642555 Escherichia coli IAI39 7152748 YP_002407572.1 CDS hns NC_011750.1 1642699 1643112 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 94335643, 95267838, 95286558, 99355427, 2404280, 11298273; Product type r : regulator; global DNA-binding transcriptional dual regulator H-NS complement(1642699..1643112) Escherichia coli IAI39 7151478 YP_002407573.1 CDS tdk NC_011750.1 1643716 1644333 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1643716..1644333 Escherichia coli IAI39 7151663 YP_002407574.1 CDS insG NC_011750.1 1644619 1645965 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element complement(1644619..1645965) Escherichia coli IAI39 7152962 YP_002407575.1 CDS adhE NC_011750.1 1646073 1648748 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12783863, 4301680, 89291706, 91200315; Product type e : enzyme; bifunctional acetaldehyde-CoA/alcohol dehydrogenase complement(1646073..1648748) Escherichia coli IAI39 7151810 YP_002407576.1 CDS ychE NC_011750.1 1649225 1649872 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1649225..1649872 Escherichia coli IAI39 7150685 YP_002407577.1 CDS ECIAI39_1577 NC_011750.1 1650030 1650344 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1650030..1650344) Escherichia coli IAI39 7153475 YP_002407578.1 CDS oppA NC_011750.1 1650610 1652241 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20256410, 86111605, 90256748, 92325017, 2015910, 9298646, 9600841, 2187863, 8740179, 9740056, 10972807; Product type t : transporter; oligopeptide ABC transporter subunit periplasmic-binding protein 1650610..1652241 Escherichia coli IAI39 7149754 YP_002407579.1 CDS oppB NC_011750.1 1652327 1653247 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606, 93106975, 2187863; Product type t : transporter; oligopeptide transporter permease 1652327..1653247 Escherichia coli IAI39 7152302 YP_002407580.1 CDS oppC NC_011750.1 1653262 1654170 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide ABC transporter membrane protein 1653262..1654170 Escherichia coli IAI39 7152303 YP_002407581.1 CDS oppD NC_011750.1 1654182 1655195 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide transporter ATP-binding protein 1654182..1655195 Escherichia coli IAI39 7152304 YP_002407582.1 CDS oppF NC_011750.1 1655192 1656196 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide ABC transporter ATP-binding protein 1655192..1656196 Escherichia coli IAI39 7152305 YP_002407583.1 CDS yciU NC_011750.1 1656249 1656578 R highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein complement(1656249..1656578) Escherichia coli IAI39 7152306 YP_002407584.1 CDS cls NC_011750.1 1656613 1658073 R catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase complement(1656613..1658073) Escherichia coli IAI39 7153497 YP_002407585.1 CDS ECIAI39_1585 NC_011750.1 1658105 1658389 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1658105..1658389 Escherichia coli IAI39 7150968 YP_002407586.1 CDS kch NC_011750.1 1658444 1659697 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12220501, 12912904, 94224769, 98319474; Product type t : transporter; voltage-gated potassium channel complement(1658444..1659697) Escherichia coli IAI39 7149755 YP_002407587.1 CDS yciI NC_011750.1 1659997 1660293 R unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; YciI-like protein complement(1659997..1660293) Escherichia coli IAI39 7151876 YP_002407588.1 CDS tonB NC_011750.1 1660466 1661233 D membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transport protein TonB 1660466..1661233 Escherichia coli IAI39 7153490 YP_002407589.1 CDS yciA NC_011750.1 1661273 1661671 R YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins; acyl-CoA thioester hydrolase complement(1661273..1661671) Escherichia coli IAI39 7153001 YP_002407590.1 CDS yciB NC_011750.1 1661776 1662315 R Involved in cell division; probably involved in intracellular septation; intracellular septation protein A complement(1661776..1662315) Escherichia coli IAI39 7153483 YP_002407591.1 CDS yciC NC_011750.1 1662345 1663088 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1662345..1663088) Escherichia coli IAI39 7153484 YP_002407592.1 CDS ompW NC_011750.1 1663444 1664082 D receptor for colicin S4; outer membrane protein W 1663444..1664082 Escherichia coli IAI39 7153485 YP_002407593.1 CDS yciE NC_011750.1 1664141 1664599 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15388941, 3058546, 8455549; hypothetical protein complement(1664141..1664599) Escherichia coli IAI39 7152298 YP_002407594.1 CDS yciF NC_011750.1 1664693 1665193 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3058546, 8455549; hypothetical protein complement(1664693..1665193) Escherichia coli IAI39 7153486 YP_002407595.1 CDS yciG NC_011750.1 1665279 1665458 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1665279..1665458) Escherichia coli IAI39 7153487 YP_002407596.1 CDS trpA NC_011750.1 1665839 1666645 R catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha complement(1665839..1666645) Escherichia coli IAI39 7153488 YP_002407597.1 CDS trpB NC_011750.1 1666645 1667838 R catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta complement(1666645..1667838) Escherichia coli IAI39 7153031 YP_002407598.1 CDS trpC NC_011750.1 1667850 1669208 R monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase complement(1667850..1669208) Escherichia coli IAI39 7153032 YP_002407599.1 CDS trpD NC_011750.1 1669212 1670807 R bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase complement(1669212..1670807) Escherichia coli IAI39 7153033 YP_002407600.1 CDS trpE NC_011750.1 1670807 1672369 R with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I complement(1670807..1672369) Escherichia coli IAI39 7153034 YP_002407602.1 CDS yciV NC_011750.1 1672643 1673524 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1672643..1673524 Escherichia coli IAI39 7153036 YP_002407603.1 CDS yciO NC_011750.1 1673521 1674141 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1673521..1674141 Escherichia coli IAI39 7153498 YP_002407604.1 CDS yciQ NC_011750.1 1674169 1676058 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1674169..1676058 Escherichia coli IAI39 7153494 YP_002407605.1 CDS rluB NC_011750.1 1676269 1677144 D catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1676269..1677144 Escherichia coli IAI39 7153495 YP_002407606.1 CDS ECIAI39_1606 NC_011750.1 1677314 1678225 D putative lipoprotein 1677314..1678225 Escherichia coli IAI39 7152642 YP_002407607.1 CDS ECIAI39_1607 NC_011750.1 1678325 1678633 D hypothetical protein 1678325..1678633 Escherichia coli IAI39 7149756 YP_002407608.1 CDS btuR NC_011750.1 1678686 1679276 R catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase complement(1678686..1679276) Escherichia coli IAI39 7149757 YP_002407609.1 CDS yciK NC_011750.1 1679273 1680031 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; short chain dehydrogenase complement(1679273..1680031) Escherichia coli IAI39 7150883 YP_002407610.1 CDS ECIAI39_1610 NC_011750.1 1680075 1680239 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1680075..1680239) Escherichia coli IAI39 7153491 YP_002407611.1 CDS sohB NC_011750.1 1680251 1681300 D SohB; periplasmic protein; member of the peptidase S49 family; putative periplasmic protease 1680251..1681300 Escherichia coli IAI39 7149758 YP_002407612.1 CDS yciN NC_011750.1 1681336 1681587 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3029379, 7567469, 9868784; hypothetical protein complement(1681336..1681587) Escherichia coli IAI39 7152874 YP_002407613.1 CDS topA NC_011750.1 1681967 1684564 D catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1681967..1684564 Escherichia coli IAI39 7153493 YP_002407614.1 CDS cysB NC_011750.1 1684774 1685748 D LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1684774..1685748 Escherichia coli IAI39 7153002 YP_002407615.1 CDS ECIAI39_1615 NC_011750.1 1686043 1686207 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1686043..1686207 Escherichia coli IAI39 7151056 YP_002407616.1 CDS ECIAI39_1616 NC_011750.1 1686189 1686377 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1686189..1686377 Escherichia coli IAI39 7149759 YP_002407617.1 CDS acnA NC_011750.1 1686751 1689426 D Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1686751..1689426 Escherichia coli IAI39 7149760 YP_002407618.1 CDS ribA NC_011750.1 1689490 1690080 R catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II complement(1689490..1690080) Escherichia coli IAI39 7150666 YP_002407619.1 CDS pgpB NC_011750.1 1690250 1691014 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89033893, 92104964; Product type e : enzyme; phosphatidylglycerophosphatase B 1690250..1691014 Escherichia coli IAI39 7152625 YP_002407620.1 CDS yciS NC_011750.1 1691163 1691471 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1691163..1691471 Escherichia coli IAI39 7152386 YP_002407621.1 CDS yciM NC_011750.1 1691478 1692647 D Evidence 4 : Homologs of previously reported genes of unknown function; tetratricopeptide repeat protein 1691478..1692647 Escherichia coli IAI39 7153496 YP_002407622.1 CDS pyrF NC_011750.1 1692839 1693576 D type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1692839..1693576 Escherichia coli IAI39 7153492 YP_002407623.1 CDS yciH NC_011750.1 1693576 1693902 D involved in start site selection during the initiation of translation; translation initiation factor Sui1 1693576..1693902 Escherichia coli IAI39 7152552 YP_002407624.1 CDS osmB NC_011750.1 1694028 1694246 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92078100, 2644204; Product type lp : lipoprotein; lipoprotein complement(1694028..1694246) Escherichia coli IAI39 7153489 YP_002407625.1 CDS deoT NC_011750.1 1694515 1695264 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16451192; Product type r : regulator; DeoR family DNA-binding transcriptional repressor complement(1694515..1695264) Escherichia coli IAI39 7152308 YP_002407626.1 CDS ECIAI39_1626 NC_011750.1 1695354 1695569 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1695354..1695569) Escherichia coli IAI39 7151122 YP_002407627.1 CDS gmr NC_011750.1 1695674 1697659 R c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP; RNase II stability modulator complement(1695674..1697659) Escherichia coli IAI39 7149761 YP_002407628.1 CDS rnb NC_011750.1 1697894 1699828 R Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II complement(1697894..1699828) Escherichia coli IAI39 7151565 YP_002407629.1 CDS yciW NC_011750.1 1699896 1701023 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amidase or amidotransferase complement(1699896..1701023) Escherichia coli IAI39 7152652 YP_002407630.1 CDS fabI NC_011750.1 1701167 1701955 R Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase complement(1701167..1701955) Escherichia coli IAI39 7153499 YP_002407631.1 CDS ECIAI39_1631 NC_011750.1 1702075 1702257 D hypothetical protein 1702075..1702257 Escherichia coli IAI39 7151269 YP_002407632.1 CDS ECIAI39_1632 NC_011750.1 1702413 1703000 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional repressor 1702413..1703000 Escherichia coli IAI39 7149762 YP_002407633.1 CDS ECIAI39_1633 NC_011750.1 1703116 1704267 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative efflux protein, membrane fusion (MFP) family 1703116..1704267 Escherichia coli IAI39 7149763 YP_002407634.1 CDS ECIAI39_1634 NC_011750.1 1704319 1704645 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 1704319..1704645 Escherichia coli IAI39 7149764 YP_002407635.1 CDS ECIAI39_1635 NC_011750.1 1704642 1705124 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 1704642..1705124 Escherichia coli IAI39 7149765 YP_002407636.1 CDS ECIAI39_1636 NC_011750.1 1705716 1707239 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative reverse transcriptase-like protein from putative prophage or plasmid 1705716..1707239 Escherichia coli IAI39 7149766 YP_002407637.1 CDS ECIAI39_1637 NC_011750.1 1707356 1707802 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 1707356..1707802 Escherichia coli IAI39 7150532 YP_002407638.1 CDS ECIAI39_1638 NC_011750.1 1707853 1710960 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative efflux pump 1707853..1710960 Escherichia coli IAI39 7149768 YP_002407639.1 CDS ECIAI39_1639 NC_011750.1 1710964 1712337 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane channel protein of an efflux system 1710964..1712337 Escherichia coli IAI39 7149769 YP_002407640.1 CDS ECIAI39_1640 NC_011750.1 1712346 1713509 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative membrane transport protein of an efflux system 1712346..1713509 Escherichia coli IAI39 7149770 YP_002407641.1 CDS sapF NC_011750.1 1713557 1714363 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 10720487, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter ATP-binding protein complement(1713557..1714363) Escherichia coli IAI39 7149771 YP_002407642.1 CDS sapD NC_011750.1 1714365 1715357 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 10720487, 9634580, 1987159; Product type t : transporter; antimicrobial peptide ABC transporter ATP-binding protein complement(1714365..1715357) Escherichia coli IAI39 7152802 YP_002407643.1 CDS sapC NC_011750.1 1715357 1716247 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter permease complement(1715357..1716247) Escherichia coli IAI39 7152801 YP_002407644.1 CDS sapB NC_011750.1 1716234 1717199 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter permease complement(1716234..1717199) Escherichia coli IAI39 7152800 YP_002407645.1 CDS sapA NC_011750.1 1717196 1718839 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide ABC transporter periplasmic-binding protein complement(1717196..1718839) Escherichia coli IAI39 7152799 YP_002407646.1 CDS ymjA NC_011750.1 1719152 1719397 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1719152..1719397) Escherichia coli IAI39 7152798 YP_002407647.1 CDS puuP NC_011750.1 1719531 1720916 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15590624; Product type t : transporter; putrescine importer complement(1719531..1720916) Escherichia coli IAI39 7154399 YP_002407648.1 CDS puuA NC_011750.1 1721219 1722637 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15590624; Product type e : enzyme; gamma-Glu-putrescine synthase complement(1721219..1722637) Escherichia coli IAI39 7152544 YP_002407649.1 CDS puuD NC_011750.1 1722849 1723613 D catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate; gamma-glutamyl-gamma-aminobutyrate hydrolase 1722849..1723613 Escherichia coli IAI39 7152539 YP_002407650.1 CDS puuR NC_011750.1 1723640 1724197 D regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR 1723640..1724197 Escherichia coli IAI39 7152542 YP_002407651.1 CDS puuC NC_011750.1 1724347 1725834 D catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation; gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 1724347..1725834 Escherichia coli IAI39 7152545 YP_002407652.1 CDS puuB NC_011750.1 1725836 1727116 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150200, 15590624; Product type e : enzyme; gamma-Glu-putrescine oxidase, FAD/NAD(P)-binding 1725836..1727116 Escherichia coli IAI39 7152541 YP_002407653.1 CDS puuE NC_011750.1 1727154 1728419 D putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate; 4-aminobutyrate transaminase 1727154..1728419 Escherichia coli IAI39 7152540 YP_002407654.1 CDS pspF NC_011750.1 1728550 1729527 R transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator complement(1728550..1729527) Escherichia coli IAI39 7152543 YP_002407655.1 CDS pspA NC_011750.1 1729694 1730362 D involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 1729694..1730362 Escherichia coli IAI39 7152507 YP_002407656.1 CDS pspB NC_011750.1 1730416 1730640 D acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B 1730416..1730640 Escherichia coli IAI39 7152502 YP_002407657.1 CDS pspC NC_011750.1 1730640 1730999 D with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; DNA-binding transcriptional activator PspC 1730640..1730999 Escherichia coli IAI39 7152503 YP_002407658.1 CDS pspD NC_011750.1 1731008 1731229 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91295203, 97303082; Product type ph : phenotype; peripheral inner membrane phage-shock protein 1731008..1731229 Escherichia coli IAI39 7152504 YP_002407659.1 CDS pspE NC_011750.1 1731304 1731618 D rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 1731304..1731618 Escherichia coli IAI39 7152505 YP_002407660.1 CDS ycjM NC_011750.1 1731832 1733511 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glucosyltransferase 1731832..1733511 Escherichia coli IAI39 7152506 YP_002407661.1 CDS ECIAI39_1661 NC_011750.1 1733326 1733616 R hypothetical protein complement(1733326..1733616) Escherichia coli IAI39 7153502 YP_002407662.1 CDS ycjN NC_011750.1 1733525 1734817 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter periplasmic-binding protein transporter 1733525..1734817 Escherichia coli IAI39 7149772 YP_002407663.1 CDS ycjO NC_011750.1 1734838 1735719 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter permease 1734838..1735719 Escherichia coli IAI39 7153503 YP_002407664.1 CDS ycjP NC_011750.1 1735706 1736548 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter permease 1735706..1736548 Escherichia coli IAI39 7153504 YP_002407665.1 CDS ycjQ NC_011750.1 1736579 1737631 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1736579..1737631 Escherichia coli IAI39 7153505 YP_002407666.1 CDS ycjR NC_011750.1 1737650 1738438 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative isomerase/epimerase 1737650..1738438 Escherichia coli IAI39 7153506 YP_002407667.1 CDS ycjS NC_011750.1 1738448 1739503 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1738448..1739503 Escherichia coli IAI39 7153507 YP_002407668.1 CDS ycjT NC_011750.1 1739500 1741767 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glycosyl hydrolase/phosphorylase 1739500..1741767 Escherichia coli IAI39 7153508 YP_002407669.1 CDS ycjU NC_011750.1 1741764 1742423 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11972617; Product type pe : putative enzyme; putative glucose-1-phosphate phosphodismutase 1741764..1742423 Escherichia coli IAI39 7153509 YP_002407670.1 CDS ycjV NC_011750.1 1742437 1743519 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter ATP-binding protein transporter 1742437..1743519 Escherichia coli IAI39 7153510 YP_002407671.1 CDS ompG NC_011750.1 1743564 1744469 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20464934, 89327119, 9721282; Product type t : transporter; outer membrane porin 1743564..1744469 Escherichia coli IAI39 7153511 YP_002407672.1 CDS ycjW NC_011750.1 1744520 1745518 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(1744520..1745518) Escherichia coli IAI39 7152293 YP_002407673.1 CDS ycjX NC_011750.1 1745662 1747059 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1745662..1747059 Escherichia coli IAI39 7153512 YP_002407674.1 CDS ycjF NC_011750.1 1747056 1748117 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1747056..1748117 Escherichia coli IAI39 7153513 YP_002407675.1 CDS tyrR NC_011750.1 1748265 1749806 D regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1748265..1749806 Escherichia coli IAI39 7153500 YP_002407676.1 CDS tpx NC_011750.1 1749850 1750356 R antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase complement(1749850..1750356) Escherichia coli IAI39 7153065 YP_002407677.1 CDS ycjG NC_011750.1 1750475 1751440 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11747447, 11747448, 7499381; Product type e : enzyme; L-Ala-D/L-Glu epimerase 1750475..1751440 Escherichia coli IAI39 7153016 YP_002407678.1 CDS mpaA NC_011750.1 1751415 1752203 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12511517; Product type e : enzyme; murein peptide amidase A complement(1751415..1752203) Escherichia coli IAI39 7153501 YP_002407679.1 CDS mppA NC_011750.1 1752326 1753939 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438753, 9495761; Product type t : transporter; murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) ABC transporter subunit periplasmic-binding protein 1752326..1753939 Escherichia coli IAI39 7152113 YP_002407680.1 CDS ynaI NC_011750.1 1753990 1755021 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1753990..1755021) Escherichia coli IAI39 7152115 YP_002407681.1 CDS ynaJ NC_011750.1 1755265 1755522 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1755265..1755522 Escherichia coli IAI39 7154400 YP_002407682.1 CDS uspE NC_011750.1 1755572 1756522 R with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE complement(1755572..1756522) Escherichia coli IAI39 7154401 YP_002407683.1 CDS fnr NC_011750.1 1756674 1757426 R Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator complement(1756674..1757426) Escherichia coli IAI39 7153109 YP_002407684.1 CDS ogt NC_011750.1 1757621 1758136 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88067749, 91161525, 94252990, 98125595, 1520330; Product type e : enzyme; O-6-alkylguanine-DNA:cysteine-protein methyltransferase complement(1757621..1758136) Escherichia coli IAI39 7151394 YP_002407685.1 CDS abgT NC_011750.1 1758147 1759673 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9829935, 2825131, 7567469; Product type t : transporter; putative aminobenzoyl-glutamate transporter complement(1758147..1759673) Escherichia coli IAI39 7152289 YP_002407686.1 CDS abgA NC_011750.1 1761144 1762454 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9829935; Product type pe : putative enzyme; putative peptidase, para-aminobenzoyl-glutamate utilization protein complement(1761144..1762454) Escherichia coli IAI39 7150652 YP_002407687.1 CDS abgR NC_011750.1 1762630 1763538 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9829935; Product type r : regulator; putative DNA-binding transcriptional regulator 1762630..1763538 Escherichia coli IAI39 7150650 YP_002407688.1 CDS ydaL NC_011750.1 1763868 1764431 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1763868..1764431 Escherichia coli IAI39 7151859 YP_002407689.1 CDS ydaM NC_011750.1 1764452 1765684 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16045609; Product type pe : putative enzyme; putative diguanylate cyclase, GG[D/E]EF domain signalling protein complement(1764452..1765684) Escherichia coli IAI39 7153514 YP_002407690.1 CDS zntB NC_011750.1 1765939 1766922 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; zinc transporter 1765939..1766922 Escherichia coli IAI39 7153515 YP_002407691.1 CDS ECIAI39_1693 NC_011750.1 1767197 1767370 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1767197..1767370 Escherichia coli IAI39 7153516 YP_002407692.1 CDS dbpA NC_011750.1 1767400 1768773 D exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA 1767400..1768773 Escherichia coli IAI39 7150886 YP_002407693.1 CDS ydaO NC_011750.1 1768902 1769837 R TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase complement(1768902..1769837) Escherichia coli IAI39 7151089 YP_002407694.1 CDS uspF NC_011750.1 1770013 1770447 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 12381839, 11849540, 9298646; Product type f : factor; stress-induced protein, ATP-binding protein complement(1770013..1770447) Escherichia coli IAI39 7153517 YP_002407695.1 CDS ompN NC_011750.1 1770588 1771721 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9642192; Product type t : transporter; outer membrane pore protein N, non-specific complement(1770588..1771721) Escherichia coli IAI39 7153110 YP_002407696.1 CDS ydbK NC_011750.1 1772082 1775606 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9025293; Product type pe : putative enzyme; putative 2-oxoacid-flavodoxin/oxidoreductase complement(1772082..1775606) Escherichia coli IAI39 7152081 YP_002407697.1 CDS ydbJ NC_011750.1 1775880 1776146 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1775880..1776146 Escherichia coli IAI39 7153523 YP_002407698.1 CDS hslJ NC_011750.1 1776143 1776613 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12892888, 8349564, 9025293; Product type f : factor; heat-inducible protein complement(1776143..1776613) Escherichia coli IAI39 7153522 YP_002407699.1 CDS ECIAI39_1701 NC_011750.1 1776575 1776901 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 1776575..1776901 Escherichia coli IAI39 7151680 YP_002407700.1 CDS ECIAI39_1702 NC_011750.1 1776898 1777380 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 1776898..1777380 Escherichia coli IAI39 7149781 YP_002407701.1 CDS ECIAI39_1703 NC_011750.1 1777972 1779495 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative reverse transcriptase-like protein from putative prophage or plasmid 1777972..1779495 Escherichia coli IAI39 7149782 YP_002407702.1 CDS ECIAI39_1704 NC_011750.1 1779612 1780058 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 1779612..1780058 Escherichia coli IAI39 7150533 YP_002407703.1 CDS ldhA NC_011750.1 1780259 1781248 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4297266, 89123040, 90198524, 8349564, 9025293; Product type e : enzyme; fermentative D-lactate dehydrogenase, NAD-dependent complement(1780259..1781248) Escherichia coli IAI39 7149784 YP_002407704.1 CDS ydbH NC_011750.1 1781456 1784095 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1781456..1784095 Escherichia coli IAI39 7151919 YP_002407705.1 CDS ynbE NC_011750.1 1784092 1784277 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein 1784092..1784277 Escherichia coli IAI39 7153521 YP_002407706.1 CDS ydbL NC_011750.1 1784282 1784608 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1784282..1784608 Escherichia coli IAI39 7154406 YP_002407707.1 CDS ydbA NC_011750.1 1785061 1790940 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : putative receptor; putative cell adhesion autotransported outer membrane protein 1785061..1790940 Escherichia coli IAI39 7153524 YP_002407708.1 CDS ydbC NC_011750.1 1791148 1792008 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 1791148..1792008 Escherichia coli IAI39 7153518 YP_002407709.1 CDS ydbD NC_011750.1 1792072 1794378 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1792072..1794378 Escherichia coli IAI39 7153519 YP_002407710.1 CDS ynbA NC_011750.1 1794542 1795153 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 1794542..1795153 Escherichia coli IAI39 7153520 YP_002407711.1 CDS ynbB NC_011750.1 1795153 1796049 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane associated CTP-phosphosubstrate transferase 1795153..1796049 Escherichia coli IAI39 7154402 YP_002407712.1 CDS ynbC NC_011750.1 1796065 1797831 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 1796065..1797831 Escherichia coli IAI39 7154403 YP_002407713.1 CDS ynbD NC_011750.1 1797845 1799137 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane associated phosphatase 1797845..1799137 Escherichia coli IAI39 7154404 YP_002407714.1 CDS azoR NC_011750.1 1799191 1799796 R FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase complement(1799191..1799796) Escherichia coli IAI39 7154405 YP_002407715.1 CDS ECIAI39_1717 NC_011750.1 1799895 1799969 D hypothetical protein 1799895..1799969 Escherichia coli IAI39 7150831 YP_002407716.1 CDS hrpA NC_011750.1 1800054 1803899 D involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1800054..1803899 Escherichia coli IAI39 7149785 YP_002407717.1 CDS ydcF NC_011750.1 1804268 1804972 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1804268..1804972 Escherichia coli IAI39 7151673 YP_002407718.1 CDS ECIAI39_1721 NC_011750.1 1806145 1806471 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 1806145..1806471 Escherichia coli IAI39 7150711 YP_002407719.1 CDS ECIAI39_1722 NC_011750.1 1806468 1807358 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 1806468..1807358 Escherichia coli IAI39 7149786 YP_002407720.1 CDS ydcE NC_011750.1 1807988 1808254 D 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 1807988..1808254 Escherichia coli IAI39 7149787 YP_002407721.1 CDS yddH NC_011750.1 1808258 1808827 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1808258..1808827) Escherichia coli IAI39 7153525 YP_002407722.1 CDS nhoA NC_011750.1 1809002 1809847 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20267568; Product type e : enzyme; N-hydroxyarylamine O-acetyltransferase 1809002..1809847 Escherichia coli IAI39 7153534 YP_002407723.1 CDS yddE NC_011750.1 1809943 1810836 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14611652, 15103639, 2233673; hypothetical protein complement(1809943..1810836) Escherichia coli IAI39 7152223 YP_002407724.1 CDS narV NC_011750.1 1810916 1811596 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type e : enzyme; nitrate reductase 2 (NRZ) subunit gamma complement(1810916..1811596) Escherichia coli IAI39 7153532 YP_002407725.1 CDS narW NC_011750.1 1811593 1812288 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410, 92186712; Product type f : factor; nitrate reductase 2 (NRZ) subunit delta complement(1811593..1812288) Escherichia coli IAI39 7152197 YP_002407726.1 CDS narY NC_011750.1 1812288 1813832 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type c : carrier; nitrate reductase 2 (NRZ) subunit beta complement(1812288..1813832) Escherichia coli IAI39 7152198 YP_002407727.1 CDS narZ NC_011750.1 1813829 1817569 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type e : enzyme; nitrate reductase 2 (NRZ) subunit alpha complement(1813829..1817569) Escherichia coli IAI39 7152200 YP_002407728.1 CDS narU NC_011750.1 1817664 1819052 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95266795, 2233673; Product type t : transporter; nitrate/nitrite transporter complement(1817664..1819052) Escherichia coli IAI39 7152201 YP_002407729.1 CDS ECIAI39_1732 NC_011750.1 1819362 1820618 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1819362..1820618) Escherichia coli IAI39 7152196 YP_002407730.1 CDS ECIAI39_1733 NC_011750.1 1820681 1821946 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1820681..1821946) Escherichia coli IAI39 7149788 YP_002407731.1 CDS ECIAI39_1734 NC_011750.1 1822110 1823210 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type m : membrane component; outer membrane porin protein ompD complement(1822110..1823210) Escherichia coli IAI39 7149789 YP_002407732.1 CDS yddG NC_011750.1 1823468 1824292 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12410826; Product type t : transporter; hypothetical protein complement(1823468..1824292) Escherichia coli IAI39 7149790 YP_002407733.1 CDS fdnG NC_011750.1 1824581 1827628 D Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-N subunit alpha, nitrate-inducible 1824581..1827628 Escherichia coli IAI39 7153533 YP_002407734.1 CDS fdnH NC_011750.1 1827641 1828525 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76005553, 90375017, 92332427, 11884747, 1834669; Product type c : carrier; formate dehydrogenase-N, Fe-S subunit beta, nitrate-inducible 1827641..1828525 Escherichia coli IAI39 7151286 YP_002407735.1 CDS fdnI NC_011750.1 1828518 1829171 D nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma 1828518..1829171 Escherichia coli IAI39 7151287 YP_002407736.1 CDS ECIAI39_1741 NC_011750.1 1829506 1829784 R Evidence 4 : Homologs of previously reported genes of unknown function; putative plasmid maintenance system killer protein complement(1829506..1829784) Escherichia coli IAI39 7153535 YP_002407737.1 CDS adhP NC_011750.1 1829970 1830980 R similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase complement(1829970..1830980) Escherichia coli IAI39 7149791 YP_002407738.1 CDS sfcA NC_011750.1 1831114 1832811 R malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase complement(1831114..1832811) Escherichia coli IAI39 7150688 YP_002407740.1 CDS bdm NC_011750.1 1833207 1833422 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10498711, 13129944; Product type f : factor; biofilm-dependent modulation protein complement(1833207..1833422) Escherichia coli IAI39 7149792 YP_002407741.1 CDS osmC NC_011750.1 1833767 1834198 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14512736, 91350191, 9298646; Product type m : membrane component; osmotically inducible, stress-inducible membrane protein 1833767..1834198 Escherichia coli IAI39 7150851 YP_002407742.1 CDS ddpF NC_011750.1 1834254 1835180 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-ala ABC transporter ATP-binding protein complement(1834254..1835180) Escherichia coli IAI39 7152309 YP_002407743.1 CDS ddpD NC_011750.1 1835173 1836159 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-ala ABC transporter ATP-binding protein complement(1835173..1836159) Escherichia coli IAI39 7151108 YP_002407744.1 CDS ddpC NC_011750.1 1836156 1837052 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; ATP-dependent peptide transporter membrane subunit complement(1836156..1837052) Escherichia coli IAI39 7151107 YP_002407745.1 CDS ddpB NC_011750.1 1837049 1838071 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-ala ABC transporter membrane protein complement(1837049..1838071) Escherichia coli IAI39 7151106 YP_002407746.1 CDS ddpA NC_011750.1 1838073 1839623 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-a la ABC transporter subunit periplasmic-binding protein complement(1838073..1839623) Escherichia coli IAI39 7151105 YP_002407747.1 CDS ddpX NC_011750.1 1839637 1840218 R catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis; D-alanyl-D-alanine dipeptidase complement(1839637..1840218) Escherichia coli IAI39 7151104 YP_002407748.1 CDS yddV NC_011750.1 1842899 1844281 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16497924, 15142243; Product type pe : putative enzyme; putative diguanylate cyclase YddV complement(1842899..1844281) Escherichia coli IAI39 7151165 YP_002407749.1 CDS yddW NC_011750.1 1844657 1845976 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10960106; Product type lp : lipoprotein; putative lipoprotein complement(1844657..1845976) Escherichia coli IAI39 7153536 YP_002407750.1 CDS gadC NC_011750.1 1846107 1847642 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15795232, 15489450; Product type t : transporter; glutamate:gamma-aminobutyric acid antiporter complement(1846107..1847642) Escherichia coli IAI39 7153537 YP_002407751.1 CDS gadB NC_011750.1 1847798 1849198 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12912902, 92155241, 92394884, 99406302, 8455549; Product type e : enzyme; glutamate decarboxylase B, PLP-dependent complement(1847798..1849198) Escherichia coli IAI39 7151465 YP_002407752.1 CDS pqqL NC_011750.1 1849561 1852356 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1659611, 11514505; Product type pe : putative enzyme; putative membrane-associated peptidase complement(1849561..1852356) Escherichia coli IAI39 7151464 YP_002407753.1 CDS yddB NC_011750.1 1852401 1854773 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative porin protein complement(1852401..1854773) Escherichia coli IAI39 7152470 YP_002407754.1 CDS yddA NC_011750.1 1854811 1856496 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative multidrug transporter fused subunits of ABC superfamily transporter: permease component; ATP-binding protein complement(1854811..1856496) Escherichia coli IAI39 7153531 YP_002407755.1 CDS ydeM NC_011750.1 1856788 1857945 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pr : putative regulator; hypothetical protein complement(1856788..1857945) Escherichia coli IAI39 7153530 YP_002407756.1 CDS ydeN NC_011750.1 1857997 1859679 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sulfatase complement(1857997..1859679) Escherichia coli IAI39 7153543 YP_002407757.1 CDS ydeO NC_011750.1 1860082 1860843 R regulates the cellular response to acid resistance; transcriptional regulator YdeO complement(1860082..1860843) Escherichia coli IAI39 7153544 YP_002407758.1 CDS ECIAI39_1765 NC_011750.1 1860918 1861115 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1860918..1861115) Escherichia coli IAI39 7153545 YP_002407759.1 CDS ydeP NC_011750.1 1861363 1863642 R in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase family; putative oxidoreductase complement(1861363..1863642) Escherichia coli IAI39 7149793 YP_002407760.1 CDS ydeQ NC_011750.1 1863981 1864895 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like exported adhesin protein complement(1863981..1864895) Escherichia coli IAI39 7153546 YP_002407761.1 CDS ECIAI39_1768 NC_011750.1 1865216 1866106 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 complement(1865216..1866106) Escherichia coli IAI39 7153547 YP_002407762.1 CDS ECIAI39_1769 NC_011750.1 1866103 1866429 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 complement(1866103..1866429) Escherichia coli IAI39 7149794 YP_002407763.1 CDS ECIAI39_1771 NC_011750.1 1867416 1867508 R hypothetical protein complement(1867416..1867508) Escherichia coli IAI39 7153548 YP_002407764.1 CDS insC NC_011750.1 1867420 1867830 D IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1867420..1867830 Escherichia coli IAI39 7149796 YP_002407765.1 CDS lsrB NC_011750.1 1871369 1872391 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11722742; Product type t : transporter; AI2 ABC transporter periplasmic-binding 1871369..1872391 Escherichia coli IAI39 7151977 YP_002407766.1 CDS lsrF NC_011750.1 1872418 1873293 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; aldolase 1872418..1873293 Escherichia coli IAI39 7151976 YP_002407767.1 CDS lsrG NC_011750.1 1873317 1873607 D Evidence 4 : Homologs of previously reported genes of unknown function; autoinducer-2 (AI-2) modifying protein LsrG 1873317..1873607 Escherichia coli IAI39 7151978 YP_002407768.1 CDS tam NC_011750.1 1873664 1874422 D catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 1873664..1874422 Escherichia coli IAI39 7151979 YP_002407769.1 CDS yneE NC_011750.1 1874426 1875340 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1874426..1875340) Escherichia coli IAI39 7152940 YP_002407770.1 CDS ECIAI39_1784 NC_011750.1 1875290 1875454 D hypothetical protein 1875290..1875454 Escherichia coli IAI39 7154408 YP_002407771.1 CDS uxaB NC_011750.1 1875537 1876988 R catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase complement(1875537..1876988) Escherichia coli IAI39 7149799 YP_002407772.1 CDS yneF NC_011750.1 1877216 1878634 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated diguanylate cyclase (GGDEF domain) complement(1877216..1878634) Escherichia coli IAI39 7153119 YP_002407773.1 CDS yneG NC_011750.1 1878773 1879132 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1878773..1879132) Escherichia coli IAI39 7154409 YP_002407774.1 CDS yneH NC_011750.1 1879132 1880058 R catalyzes the formation of glutamate from glutamine; glutaminase complement(1879132..1880058) Escherichia coli IAI39 7154410 YP_002407775.1 CDS yneI NC_011750.1 1880122 1881510 R in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; putative succinate semialdehyde dehydrogenase complement(1880122..1881510) Escherichia coli IAI39 7154411 YP_002407776.1 CDS D NC_011750.1 1882552 1883652 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; late control gene D protein complement(1882552..1883652) Escherichia coli IAI39 7154413 YP_002407777.1 CDS U NC_011750.1 1883649 1884134 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; bacteriophage tail protein GpU complement(1883649..1884134) Escherichia coli IAI39 7151075 YP_002407778.1 CDS ECIAI39_1793 NC_011750.1 1884131 1887208 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail tape measure protein complement(1884131..1887208) Escherichia coli IAI39 7153067 YP_002407779.1 CDS ECIAI39_1794 NC_011750.1 1887335 1887637 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail protein E complement(1887335..1887637) Escherichia coli IAI39 7149800 YP_002407780.1 CDS fII NC_011750.1 1887692 1888207 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail sheath protein FII complement(1887692..1888207) Escherichia coli IAI39 7149801 YP_002407781.1 CDS fI NC_011750.1 1888217 1889389 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail sheath protein FI complement(1888217..1889389) Escherichia coli IAI39 7151327 YP_002407782.1 CDS ECIAI39_1797 NC_011750.1 1889603 1890325 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase, IS26 complement(1889603..1890325) Escherichia coli IAI39 7151323 YP_002407783.1 CDS I NC_011750.1 1891516 1892121 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail protein I (GpI) complement(1891516..1892121) Escherichia coli IAI39 7149803 YP_002407784.1 CDS J NC_011750.1 1892114 1893061 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpJ complement(1892114..1893061) Escherichia coli IAI39 7151740 YP_002407785.1 CDS W NC_011750.1 1893009 1893368 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpW complement(1893009..1893368) Escherichia coli IAI39 7151869 YP_002407786.1 CDS V NC_011750.1 1893365 1893943 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein GpV complement(1893365..1893943) Escherichia coli IAI39 7153133 YP_002407787.1 CDS ECIAI39_1803 NC_011750.1 1894012 1894458 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail completion protein complement(1894012..1894458) Escherichia coli IAI39 7153124 YP_002407788.1 CDS R NC_011750.1 1894451 1894903 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail completion protein R (GpR) complement(1894451..1894903) Escherichia coli IAI39 7149804 YP_002407789.1 CDS ECIAI39_1805 NC_011750.1 1894845 1895135 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1894845..1895135) Escherichia coli IAI39 7152563 YP_002407790.1 CDS ECIAI39_1806 NC_011750.1 1894978 1895406 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative regulatory protein complement(1894978..1895406) Escherichia coli IAI39 7149805 YP_002407791.1 CDS ECIAI39_1807 NC_011750.1 1895403 1895852 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1895403..1895852) Escherichia coli IAI39 7149806 YP_002407792.1 CDS R NC_011750.1 1895782 1896294 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; putative lysozyme protein R of prophage complement(1895782..1896294) Escherichia coli IAI39 7149807 YP_002407793.1 CDS ECIAI39_1809 NC_011750.1 1896275 1896490 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative secretory protein complement(1896275..1896490) Escherichia coli IAI39 7152564 YP_002407794.1 CDS X NC_011750.1 1896494 1896697 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage tail protein X (GpX) complement(1896494..1896697) Escherichia coli IAI39 7149808 YP_002407795.1 CDS L NC_011750.1 1896697 1897224 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head completion/stabilization protein (GpL) complement(1896697..1897224) Escherichia coli IAI39 7153171 YP_002407796.1 CDS M NC_011750.1 1897257 1897907 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; terminase, endonuclease subunit (GpM) complement(1897257..1897907) Escherichia coli IAI39 7151911 YP_002407797.1 CDS N NC_011750.1 1897911 1898969 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor capsid protein H1 and H2, major capsid protein N* complement(1897911..1898969) Escherichia coli IAI39 7151989 YP_002407798.1 CDS O NC_011750.1 1898986 1899819 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; putative capsid scaffolding protein GpO complement(1898986..1899819) Escherichia coli IAI39 7152163 YP_002407799.1 CDS ECIAI39_1816 NC_011750.1 1901114 1901836 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase, IS26 1901114..1901836 Escherichia coli IAI39 7152317 YP_002407800.1 CDS ECIAI39_1818 NC_011750.1 1902553 1903590 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage portal protein 1902553..1903590 Escherichia coli IAI39 7152318 YP_002407801.1 CDS ECIAI39_1819 NC_011750.1 1903720 1904046 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 1903720..1904046 Escherichia coli IAI39 7149810 YP_002407802.1 CDS ECIAI39_1820 NC_011750.1 1904043 1904933 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 1904043..1904933 Escherichia coli IAI39 7149811 YP_002407803.1 CDS yneK NC_011750.1 1905868 1906983 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1905868..1906983 Escherichia coli IAI39 7154414 YP_002407804.1 CDS ydeA NC_011750.1 1907133 1908323 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10094697, 99369894, 8383113, 10438792; Product type t : transporter; sugar efflux transporter 1907133..1908323 Escherichia coli IAI39 7154415 YP_002407805.1 CDS marC NC_011750.1 1908348 1909013 R protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC complement(1908348..1909013) Escherichia coli IAI39 7153538 YP_002407806.1 CDS marR NC_011750.1 1909225 1909659 D Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; DNA-binding transcriptional repressor MarR 1909225..1909659 Escherichia coli IAI39 7152016 YP_002407807.1 CDS marA NC_011750.1 1909680 1910063 D transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; DNA-binding transcriptional activator MarA 1909680..1910063 Escherichia coli IAI39 7152017 YP_002407808.1 CDS marB NC_011750.1 1910095 1910313 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8383113; hypothetical protein 1910095..1910313 Escherichia coli IAI39 7152014 YP_002407809.1 CDS celA NC_011750.1 1910370 1911815 R converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase complement(1910370..1911815) Escherichia coli IAI39 7152015 YP_002407810.1 CDS ECIAI39_1830 NC_011750.1 1911834 1913507 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative carbohydrate-specific outer membrane porin complement(1911834..1913507) Escherichia coli IAI39 7149814 YP_002407811.1 CDS ECIAI39_1831 NC_011750.1 1913563 1913880 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system PTS, lactose/cellobiose-specific IIA subunit complement(1913563..1913880) Escherichia coli IAI39 7149815 YP_002407812.1 CDS ECIAI39_1832 NC_011750.1 1913902 1915224 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system IIC component complement(1913902..1915224) Escherichia coli IAI39 7149816 YP_002407813.1 CDS ECIAI39_1833 NC_011750.1 1915338 1915649 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative cellobiose-specific phosphotransferase enzyme IIB component complement(1915338..1915649) Escherichia coli IAI39 7149817 YP_002407814.1 CDS ECIAI39_1834 NC_011750.1 1915848 1916546 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator HTH family 1915848..1916546 Escherichia coli IAI39 7149818 YP_002407815.1 CDS eamA NC_011750.1 1916591 1917490 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20305052; Product type t : transporter; O-acetylserine/cysteine export protein complement(1916591..1917490) Escherichia coli IAI39 7149819 YP_002407816.1 CDS ydeE NC_011750.1 1917685 1918872 D YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters; putative MFS-type transporter YdeE 1917685..1918872 Escherichia coli IAI39 7151194 YP_002407817.1 CDS ECIAI39_1837 NC_011750.1 1918904 1919302 R hypothetical protein complement(1918904..1919302) Escherichia coli IAI39 7153539 YP_002407818.1 CDS ftrA NC_011750.1 1919355 1920368 D upregulated by FixLJ/FixK under oxygen limitation; involved in regulation of genes involved in carbon and amino acid metabolism; transcriptional activator FtrA 1919355..1920368 Escherichia coli IAI39 7149820 YP_002407819.1 CDS ydeH NC_011750.1 1920790 1921680 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1920790..1921680) Escherichia coli IAI39 7149821 YP_002407820.1 CDS ydeI NC_011750.1 1921935 1922327 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1921935..1922327) Escherichia coli IAI39 7153540 YP_002407821.1 CDS dcp NC_011750.1 1922693 1924738 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 216006, 8226676; Product type e : enzyme; dipeptidyl carboxypeptidase II complement(1922693..1924738) Escherichia coli IAI39 7153541 YP_002407822.1 CDS ydfG NC_011750.1 1924875 1925621 D NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase 1924875..1925621 Escherichia coli IAI39 7151092 YP_002407823.1 CDS ydfH NC_011750.1 1925710 1926396 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1925710..1926396 Escherichia coli IAI39 7153549 YP_002407824.1 CDS ydfZ NC_011750.1 1926574 1926777 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12084818; Product type pc : putative carrier; putative selenium carrying protein 1926574..1926777 Escherichia coli IAI39 7153550 YP_002407825.1 CDS ydfI NC_011750.1 1926813 1928273 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative mannonate dehydrogenase complement(1926813..1928273) Escherichia coli IAI39 7153561 YP_002407826.1 CDS ydfJ NC_011750.1 1928363 1929646 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(1928363..1929646) Escherichia coli IAI39 7153551 YP_002407827.1 CDS ydfK NC_011750.1 1930399 1930665 D Evidence 4 : Homologs of previously reported genes of unknown function; putative DNA-binding transcriptional regulator; Qin prophage 1930399..1930665 Escherichia coli IAI39 7153552 YP_002407828.1 CDS ECIAI39_1849 NC_011750.1 1931384 1932274 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 complement(1931384..1932274) Escherichia coli IAI39 7152422 YP_002407829.1 CDS ECIAI39_1850 NC_011750.1 1932271 1932597 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 complement(1932271..1932597) Escherichia coli IAI39 7149822 YP_002407830.1 CDS ECIAI39_1851 NC_011750.1 1932603 1933256 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1932603..1933256) Escherichia coli IAI39 7149823 YP_002407831.1 CDS ECIAI39_1852 NC_011750.1 1933266 1933547 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1933266..1933547) Escherichia coli IAI39 7149824 YP_002407832.1 CDS ECIAI39_1853 NC_011750.1 1933544 1935949 R Evidence 4 : Homologs of previously reported genes of unknown function; putative prophage side tail fiber protein complement(1933544..1935949) Escherichia coli IAI39 7149825 YP_002407833.1 CDS ECIAI39_1854 NC_011750.1 1936008 1936607 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Lom-like outer membrane protein of prophage complement(1936008..1936607) Escherichia coli IAI39 7149826 YP_002407834.1 CDS ECIAI39_1855 NC_011750.1 1936675 1940475 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J complement(1936675..1940475) Escherichia coli IAI39 7149827 YP_002407835.1 CDS ECIAI39_1856 NC_011750.1 1940819 1941499 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein I complement(1940819..1941499) Escherichia coli IAI39 7149828 YP_002407836.1 CDS K NC_011750.1 1941397 1942140 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein K complement(1941397..1942140) Escherichia coli IAI39 7149829 YP_002407837.1 CDS ECIAI39_1858 NC_011750.1 1942146 1942844 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein L complement(1942146..1942844) Escherichia coli IAI39 7151870 YP_002407838.1 CDS ECIAI39_1859 NC_011750.1 1942844 1943173 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein M complement(1942844..1943173) Escherichia coli IAI39 7149830 YP_002407839.1 CDS ECIAI39_1860 NC_011750.1 1943170 1945731 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein H complement(1943170..1945731) Escherichia coli IAI39 7149831 YP_002407840.1 CDS ECIAI39_1861 NC_011750.1 1945712 1946125 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein T complement(1945712..1946125) Escherichia coli IAI39 7149832 YP_002407841.1 CDS ECIAI39_1862 NC_011750.1 1946152 1946583 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein G complement(1946152..1946583) Escherichia coli IAI39 7149833 YP_002407842.1 CDS ECIAI39_1863 NC_011750.1 1946602 1947348 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail protein V complement(1946602..1947348) Escherichia coli IAI39 7149834 YP_002407843.1 CDS ECIAI39_1864 NC_011750.1 1947356 1947751 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein U complement(1947356..1947751) Escherichia coli IAI39 7149835 YP_002407844.1 CDS ECIAI39_1865 NC_011750.1 1947748 1948281 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein Z (GpZ) complement(1947748..1948281) Escherichia coli IAI39 7149836 YP_002407845.1 CDS ECIAI39_1866 NC_011750.1 1948297 1948650 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail attachment protein complement(1948297..1948650) Escherichia coli IAI39 7149837 YP_002407846.1 CDS ECIAI39_1867 NC_011750.1 1948643 1949074 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1948643..1949074) Escherichia coli IAI39 7149838 YP_002407847.1 CDS ECIAI39_1868 NC_011750.1 1949078 1950106 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major head protein complement(1949078..1950106) Escherichia coli IAI39 7149839 YP_002407848.1 CDS ECIAI39_1869 NC_011750.1 1950164 1950511 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head decoration protein (gpD) (major capsid protein D) complement(1950164..1950511) Escherichia coli IAI39 7149840 YP_002407849.1 CDS ECIAI39_1870 NC_011750.1 1950548 1952053 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head-tail preconnector protein GP5 complement(1950548..1952053) Escherichia coli IAI39 7149841 YP_002407850.1 CDS ECIAI39_1871 NC_011750.1 1952043 1953635 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head protein Gp4 complement(1952043..1953635) Escherichia coli IAI39 7149842 YP_002407851.1 CDS ECIAI39_1872 NC_011750.1 1953632 1953838 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; head stabilization protein (head protein GP3) complement(1953632..1953838) Escherichia coli IAI39 7149843 YP_002407852.1 CDS ECIAI39_1873 NC_011750.1 1953822 1955750 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; terminase large subunit (Gp2) complement(1953822..1955750) Escherichia coli IAI39 7149844 YP_002407853.1 CDS ECIAI39_1874 NC_011750.1 1955722 1956231 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative terminase small subunit (DNA packaging protein Nu1) from bacteriophage origin complement(1955722..1956231) Escherichia coli IAI39 7149845 YP_002407854.1 CDS ECIAI39_1875 NC_011750.1 1956561 1956887 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 1956561..1956887 Escherichia coli IAI39 7149846 YP_002407855.1 CDS ECIAI39_1876 NC_011750.1 1956884 1957366 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 1956884..1957366 Escherichia coli IAI39 7149847 YP_002407856.1 CDS ECIAI39_1877 NC_011750.1 1957958 1959481 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative reverse transcriptase-like protein from putative prophage or plasmid 1957958..1959481 Escherichia coli IAI39 7149848 YP_002407857.1 CDS ECIAI39_1878 NC_011750.1 1959658 1960044 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 1959658..1960044 Escherichia coli IAI39 7150534 YP_002407858.1 CDS dadX NC_011750.1 1960855 1961925 R catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA; alanine racemase complement(1960855..1961925) Escherichia coli IAI39 7149851 YP_002407859.1 CDS dadA NC_011750.1 1961935 1963233 R catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit complement(1961935..1963233) Escherichia coli IAI39 7151081 YP_002407860.1 CDS ycgB NC_011750.1 1963563 1965095 D Evidence 4 : Homologs of previously reported genes of unknown function; SpoVR family protein 1963563..1965095 Escherichia coli IAI39 7151080 YP_002407861.1 CDS fadR NC_011750.1 1965147 1965866 R Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator complement(1965147..1965866) Escherichia coli IAI39 7153462 YP_002407862.1 CDS nhaB NC_011750.1 1966089 1967630 D involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter 1966089..1967630 Escherichia coli IAI39 7151278 YP_002407863.1 CDS dsbB NC_011750.1 1967776 1968306 D disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 1967776..1968306 Escherichia coli IAI39 7152221 YP_002407864.1 CDS umuC NC_011750.1 1968352 1969620 R binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC complement(1968352..1969620) Escherichia coli IAI39 7151173 YP_002407865.1 CDS umuD NC_011750.1 1969620 1970039 R binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD complement(1969620..1970039) Escherichia coli IAI39 7153102 YP_002407866.1 CDS ECIAI39_1889 NC_011750.1 1970283 1970690 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1970283..1970690 Escherichia coli IAI39 7153103 YP_002407867.1 CDS ECIAI39_1890 NC_011750.1 1970709 1971929 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase 1970709..1971929 Escherichia coli IAI39 7149852 YP_002407868.1 CDS hlyE NC_011750.1 1972304 1973215 D Acts by forming a pore-like structure upon contact with mammalian cells; hemolysin E 1972304..1973215 Escherichia coli IAI39 7150885 YP_002407869.1 CDS ycgN NC_011750.1 1973422 1973868 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1973422..1973868) Escherichia coli IAI39 7151661 YP_002407870.1 CDS ycgM NC_011750.1 1973960 1974619 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15551868; Product type pe : putative enzyme; hypothetical protein complement(1973960..1974619) Escherichia coli IAI39 7153470 YP_002407871.1 CDS ycgL NC_011750.1 1974691 1975017 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1974691..1975017) Escherichia coli IAI39 7153469 YP_002407872.1 CDS ycgK NC_011750.1 1975225 1975626 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1975225..1975626 Escherichia coli IAI39 7153468 YP_002407873.1 CDS ycgJ NC_011750.1 1975746 1976114 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1975746..1976114) Escherichia coli IAI39 7153467 YP_002407874.1 CDS minC NC_011750.1 1976634 1977329 D blocks the formation of polar Z-ring septums; septum formation inhibitor 1976634..1977329 Escherichia coli IAI39 7153466 YP_002407875.1 CDS minD NC_011750.1 1977353 1978165 D ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD 1977353..1978165 Escherichia coli IAI39 7152083 YP_002407876.1 CDS minE NC_011750.1 1978169 1978435 D works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 1978169..1978435 Escherichia coli IAI39 7152084 YP_002407877.1 CDS ECIAI39_1900 NC_011750.1 1978801 1979244 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1978801..1979244) Escherichia coli IAI39 7152085 YP_002407878.1 CDS ECIAI39_1901 NC_011750.1 1979546 1979719 D hypothetical protein 1979546..1979719 Escherichia coli IAI39 7149854 YP_002407879.1 CDS ymgG NC_011750.1 1979790 1980065 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1979790..1980065 Escherichia coli IAI39 7149855 YP_002407880.1 CDS ymgD NC_011750.1 1980075 1980404 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1980075..1980404 Escherichia coli IAI39 7154398 YP_002407881.1 CDS ECIAI39_1904 NC_011750.1 1980462 1983110 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane autotransporter barrel, putative pectin lyase fold complement(1980462..1983110) Escherichia coli IAI39 7154396 YP_002407882.1 CDS ycgG NC_011750.1 1983860 1985383 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(1983860..1985383) Escherichia coli IAI39 7149856 YP_002407883.1 CDS ECIAI39_1907 NC_011750.1 1985791 1986117 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 1985791..1986117 Escherichia coli IAI39 7153465 YP_002407884.1 CDS ECIAI39_1908 NC_011750.1 1986114 1987004 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 1986114..1987004 Escherichia coli IAI39 7149857 YP_002407885.1 CDS ymgC NC_011750.1 1987044 1987280 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1987044..1987280) Escherichia coli IAI39 7149858 YP_002407886.1 CDS ymgB NC_011750.1 1987393 1987659 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1987393..1987659) Escherichia coli IAI39 7154395 YP_002407887.1 CDS ymgA NC_011750.1 1987688 1987960 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1987688..1987960) Escherichia coli IAI39 7154394 YP_002407888.1 CDS ycgZ NC_011750.1 1988003 1988239 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1988003..1988239) Escherichia coli IAI39 7154393 YP_002407889.1 CDS ycgF NC_011750.1 1988553 1989764 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16533062, 15453820; Product type pe : putative enzyme; putative blue-light sensing cyclic-di-GMP phosphodiesterase 1988553..1989764 Escherichia coli IAI39 7153473 YP_002407890.1 CDS ycgE NC_011750.1 1989969 1990700 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 1989969..1990700 Escherichia coli IAI39 7153464 YP_002407891.1 CDS ycgX NC_011750.1 1990921 1991325 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1990921..1991325 Escherichia coli IAI39 7153463 YP_002407892.1 CDS elbA NC_011750.1 1992030 1992353 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9603997; hypothetical protein 1992030..1992353 Escherichia coli IAI39 7153472 YP_002407893.1 CDS ECIAI39_1918 NC_011750.1 1993080 1993850 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1993080..1993850) Escherichia coli IAI39 7151750 YP_002407894.1 CDS sitA NC_011750.1 1994537 1995451 D Evidence 2b : Function of strongly homologous gene; PubMedId : 12654809, 10085045; Product type t : transporter; iron transport protein, periplasmic-binding protein 1994537..1995451 Escherichia coli IAI39 7149859 YP_002407895.1 CDS sitB NC_011750.1 1995451 1996278 D Evidence 2b : Function of strongly homologous gene; PubMedId : 12654809, 10085045; Product type m : membrane component; iron transport protein, ATP-binding protein 1995451..1996278 Escherichia coli IAI39 7152853 YP_002407896.1 CDS sitC NC_011750.1 1996275 1997132 D Evidence 2b : Function of strongly homologous gene; PubMedId : 12654809, 10085045; Product type m : membrane component; iron transporter inner membrane component 1996275..1997132 Escherichia coli IAI39 7152854 YP_002407897.1 CDS sitD NC_011750.1 1997129 1997986 D Evidence 2b : Function of strongly homologous gene; PubMedId : 12654809, 10085045; Product type m : membrane component; iron transporter inner membrane component 1997129..1997986 Escherichia coli IAI39 7152855 YP_002407898.1 CDS ECIAI39_1923 NC_011750.1 1998078 1998371 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1998078..1998371) Escherichia coli IAI39 7152856 YP_002407899.1 CDS ECIAI39_1924 NC_011750.1 1998382 1999086 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1998382..1999086) Escherichia coli IAI39 7149860 YP_002407900.1 CDS ECIAI39_1925 NC_011750.1 1999096 1999377 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1999096..1999377) Escherichia coli IAI39 7149861 YP_002407901.1 CDS ECIAI39_1926 NC_011750.1 1999374 2001779 R Evidence 4 : Homologs of previously reported genes of unknown function; putative prophage side tail fiber protein complement(1999374..2001779) Escherichia coli IAI39 7149862 YP_002407902.1 CDS ECIAI39_1928 NC_011750.1 2002172 2002561 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA-binding protein from phage origin complement(2002172..2002561) Escherichia coli IAI39 7149864 YP_002407903.1 CDS ECIAI39_1929 NC_011750.1 2002533 2003024 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2002533..2003024) Escherichia coli IAI39 7149865 YP_002407904.1 CDS ECIAI39_1930 NC_011750.1 2003180 2003410 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2003180..2003410) Escherichia coli IAI39 7149866 YP_002407905.1 CDS ECIAI39_1931 NC_011750.1 2003407 2004126 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2003407..2004126) Escherichia coli IAI39 7149867 YP_002407906.1 CDS ECIAI39_1932 NC_011750.1 2004087 2004302 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2004087..2004302) Escherichia coli IAI39 7149868 YP_002407907.1 CDS ECIAI39_1933 NC_011750.1 2004317 2004613 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2004317..2004613) Escherichia coli IAI39 7149869 YP_002407908.1 CDS ECIAI39_1934 NC_011750.1 2004623 2004895 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2004623..2004895) Escherichia coli IAI39 7149870 YP_002407909.1 CDS gam NC_011750.1 2005184 2005714 R Evidence 2b : Function of strongly homologous gene; PubMedId : 2945162; Product type h : extrachromosomal origin; Host-nuclease inhibitor protein from bacteriophage complement(2005184..2005714) Escherichia coli IAI39 7149871 YP_002407910.1 CDS ECIAI39_1936 NC_011750.1 2006014 2007207 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2006014..2007207) Escherichia coli IAI39 7151479 YP_002407911.1 CDS ECIAI39_1937 NC_011750.1 2007191 2008960 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2007191..2008960) Escherichia coli IAI39 7149872 YP_002407912.1 CDS ECIAI39_1938 NC_011750.1 2008964 2009878 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2008964..2009878) Escherichia coli IAI39 7149873 YP_002407913.1 CDS ECIAI39_1939 NC_011750.1 2009889 2010197 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage-related DNA-binding protein complement(2009889..2010197) Escherichia coli IAI39 7149874 YP_002407914.1 CDS ECIAI39_1940 NC_011750.1 2010250 2010438 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage-related DNA-binding protein complement(2010250..2010438) Escherichia coli IAI39 7149875 YP_002407915.1 CDS ECIAI39_1941 NC_011750.1 2010489 2010950 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA-binding protein from phage origin 2010489..2010950 Escherichia coli IAI39 7149876 YP_002407916.1 CDS ECIAI39_1942 NC_011750.1 2010947 2011933 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2010947..2011933 Escherichia coli IAI39 7149877 YP_002407917.1 CDS ECIAI39_1943 NC_011750.1 2012015 2012605 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 2012015..2012605 Escherichia coli IAI39 7149878 YP_002407918.1 CDS ECIAI39_1944 NC_011750.1 2012643 2013119 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATPase complement(2012643..2013119) Escherichia coli IAI39 7149879 YP_002407919.1 CDS ECIAI39_1945 NC_011750.1 2013202 2013600 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative phage-related membrane protein 2013202..2013600 Escherichia coli IAI39 7149880 YP_002407920.1 CDS ECIAI39_1946 NC_011750.1 2013603 2014343 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phage-related lytic murein transglycosylase 2013603..2014343 Escherichia coli IAI39 7149881 YP_002407921.1 CDS ECIAI39_1947 NC_011750.1 2014327 2014977 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative phage-related lipoprotein 2014327..2014977 Escherichia coli IAI39 7149882 YP_002407922.1 CDS ECIAI39_1948 NC_011750.1 2014974 2015300 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative membrane protein from phage origin 2014974..2015300 Escherichia coli IAI39 7149883 YP_002407923.1 CDS ECIAI39_1949 NC_011750.1 2015300 2015611 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2015300..2015611 Escherichia coli IAI39 7149884 YP_002407924.1 CDS ECIAI39_1950 NC_011750.1 2015611 2016060 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2015611..2016060 Escherichia coli IAI39 7149885 YP_002407925.1 CDS ECIAI39_1951 NC_011750.1 2016153 2017748 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage-related protein 2016153..2017748 Escherichia coli IAI39 7149886 YP_002407926.1 CDS ECIAI39_1952 NC_011750.1 2017748 2019244 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2017748..2019244 Escherichia coli IAI39 7149887 YP_002407927.1 CDS ECIAI39_1953 NC_011750.1 2019225 2020046 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head morphogenesis protein of bacteriophage 2019225..2020046 Escherichia coli IAI39 7149888 YP_002407928.1 CDS ECIAI39_1954 NC_011750.1 2020049 2020507 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage virion morphogenesis protein 2020049..2020507 Escherichia coli IAI39 7149889 YP_002407929.1 CDS ECIAI39_1955 NC_011750.1 2020722 2021837 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2020722..2021837 Escherichia coli IAI39 7149890 YP_002407930.1 CDS ECIAI39_1956 NC_011750.1 2021852 2022805 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2021852..2022805 Escherichia coli IAI39 7149891 YP_002407931.1 CDS ECIAI39_1957 NC_011750.1 2022815 2023153 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2022815..2023153 Escherichia coli IAI39 7149892 YP_002407932.1 CDS ECIAI39_1958 NC_011750.1 2023155 2023601 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2023155..2023601 Escherichia coli IAI39 7149893 YP_002407933.1 CDS ECIAI39_1959 NC_011750.1 2023601 2024065 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2023601..2024065 Escherichia coli IAI39 7149894 YP_002407934.1 CDS ECIAI39_1960 NC_011750.1 2024062 2024316 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2024062..2024316 Escherichia coli IAI39 7149895 YP_002407935.1 CDS ECIAI39_1961 NC_011750.1 2024306 2025733 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail sheath protein 2024306..2025733 Escherichia coli IAI39 7149896 YP_002407936.1 CDS ECIAI39_1962 NC_011750.1 2025733 2026254 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail core protein 2025733..2026254 Escherichia coli IAI39 7149897 YP_002407937.1 CDS ECIAI39_1963 NC_011750.1 2026305 2026439 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2026305..2026439 Escherichia coli IAI39 7149898 YP_002407938.1 CDS ECIAI39_1964 NC_011750.1 2026636 2026971 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2026636..2026971 Escherichia coli IAI39 7149899 YP_002407939.1 CDS ECIAI39_1965 NC_011750.1 2027129 2030080 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage minor tail protein 2027129..2030080 Escherichia coli IAI39 7149900 YP_002407940.1 CDS ECIAI39_1966 NC_011750.1 2030080 2030964 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; hypothetical protein 2030080..2030964 Escherichia coli IAI39 7149901 YP_002407941.1 CDS ECIAI39_1967 NC_011750.1 2030961 2031176 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail protein 2030961..2031176 Escherichia coli IAI39 7149902 YP_002407942.1 CDS ECIAI39_1968 NC_011750.1 2031164 2032318 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative control protein for phage late genes expression 2031164..2032318 Escherichia coli IAI39 7149903 YP_002407943.1 CDS ECIAI39_1969 NC_011750.1 2032315 2032911 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage baseplate component 2032315..2032911 Escherichia coli IAI39 7149904 YP_002407944.1 CDS ECIAI39_1971 NC_011750.1 2033304 2034407 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative bacteriophage baseplate assembly protein 2033304..2034407 Escherichia coli IAI39 7149906 YP_002407945.1 CDS ECIAI39_1972 NC_011750.1 2034400 2034978 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage tail fiber protein 2034400..2034978 Escherichia coli IAI39 7149907 YP_002407946.1 CDS ECIAI39_1973 NC_011750.1 2034981 2037041 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative side tail fiber protein from lambdoid prophage 2034981..2037041 Escherichia coli IAI39 7149908 YP_002407947.1 CDS ECIAI39_1974 NC_011750.1 2037048 2037662 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber chaperone (assembly protein) from lambdoid prophage complement(2037048..2037662) Escherichia coli IAI39 7149909 YP_002407948.1 CDS pin NC_011750.1 2038246 2038818 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; DNA-invertase (site specific recombinase) from prophage 2038246..2038818 Escherichia coli IAI39 7149911 YP_002407949.1 CDS ECIAI39_1977 NC_011750.1 2038856 2039329 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Lom-like outer membrane protein of prophage complement(2038856..2039329) Escherichia coli IAI39 7152420 YP_002407950.1 CDS ECIAI39_1979 NC_011750.1 2039567 2040115 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; terminase small subunit (Gp1) complement(2039567..2040115) Escherichia coli IAI39 7149913 YP_002407951.1 CDS ECIAI39_1980 NC_011750.1 2040197 2040451 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2040197..2040451) Escherichia coli IAI39 7149914 YP_002407952.1 CDS ECIAI39_1981 NC_011750.1 2040313 2040516 D hypothetical protein 2040313..2040516 Escherichia coli IAI39 7149915 YP_002407953.1 CDS ECIAI39_1982 NC_011750.1 2040678 2040860 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2040678..2040860) Escherichia coli IAI39 7149916 YP_002407954.1 CDS ECIAI39_1983 NC_011750.1 2041067 2041447 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tonB-like membrane protein encoded within prophage complement(2041067..2041447) Escherichia coli IAI39 7149917 YP_002407955.1 CDS ECIAI39_1985 NC_011750.1 2042038 2042928 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 complement(2042038..2042928) Escherichia coli IAI39 7150874 YP_002407956.1 CDS ECIAI39_1986 NC_011750.1 2042925 2043251 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 complement(2042925..2043251) Escherichia coli IAI39 7149919 YP_002407957.1 CDS ECIAI39_1987 NC_011750.1 2043372 2043740 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative single-stranded DNA binding protein of prophage 2043372..2043740 Escherichia coli IAI39 7149920 YP_002407958.1 CDS kil NC_011750.1 2043820 2044089 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host killing protein from bacteriophage origin 2043820..2044089 Escherichia coli IAI39 7149921 YP_002407959.1 CDS ECIAI39_1989 NC_011750.1 2044165 2044461 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative host-nuclease inhibitor protein Gam of bacteriophage 2044165..2044461 Escherichia coli IAI39 7151899 YP_002407960.1 CDS ECIAI39_1990 NC_011750.1 2044467 2045252 D Evidence 2b : Function of strongly homologous gene; PubMedId : 6458018, 6221115; Product type h : extrachromosomal origin; Recombination protein bet from phage origin 2044467..2045252 Escherichia coli IAI39 7149922 YP_002407961.1 CDS ECIAI39_1991 NC_011750.1 2045249 2045929 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; exonuclease from phage origin 2045249..2045929 Escherichia coli IAI39 7149923 YP_002407962.1 CDS ECIAI39_1992 NC_011750.1 2046081 2046833 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2046081..2046833 Escherichia coli IAI39 7149924 YP_002407963.1 CDS ECIAI39_1993 NC_011750.1 2046841 2047056 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2046841..2047056 Escherichia coli IAI39 7149925 YP_002407964.1 CDS ymfG NC_011750.1 2047800 2048036 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative excisionase 2047800..2048036 Escherichia coli IAI39 7149926 YP_002407965.1 CDS icd NC_011750.1 2049282 2050532 R Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase complement(2049282..2050532) Escherichia coli IAI39 7154387 YP_002407966.1 CDS ECIAI39_1996 NC_011750.1 2050866 2051159 R hypothetical protein complement(2050866..2051159) Escherichia coli IAI39 7151751 YP_002407967.1 CDS ECIAI39_1997 NC_011750.1 2051112 2051510 D hypothetical protein 2051112..2051510 Escherichia coli IAI39 7149927 YP_002407968.1 CDS ECIAI39_1998 NC_011750.1 2051513 2052403 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 complement(2051513..2052403) Escherichia coli IAI39 7149928 YP_002407969.1 CDS ECIAI39_1999 NC_011750.1 2052400 2052726 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 complement(2052400..2052726) Escherichia coli IAI39 7149929 YP_002407970.1 CDS ECIAI39_2000 NC_011750.1 2052859 2053209 D putative cytoplasmic protein 2052859..2053209 Escherichia coli IAI39 7149930 YP_002407971.1 CDS ymfC NC_011750.1 2053530 2054180 D catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E 2053530..2054180 Escherichia coli IAI39 7149931 YP_002407972.1 CDS ymfB NC_011750.1 2054190 2054651 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217; Product type e : enzyme; bifunctional thiamin pyrimidine pyrophosphate hydrolase and thiamin pyrophosphate hydrolase 2054190..2054651 Escherichia coli IAI39 7154386 YP_002407973.1 CDS mnmA NC_011750.1 2054705 2055811 D catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 2054705..2055811 Escherichia coli IAI39 7154385 YP_002407974.1 CDS hflD NC_011750.1 2055847 2056488 D HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 2055847..2056488 Escherichia coli IAI39 7153030 YP_002407975.1 CDS purB NC_011750.1 2056492 2057862 D Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 2056492..2057862 Escherichia coli IAI39 7151638 YP_002407976.1 CDS phoP NC_011750.1 2058031 2058702 D response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP 2058031..2058702 Escherichia coli IAI39 7152524 YP_002407977.1 CDS phoQ NC_011750.1 2058702 2060162 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92105017; Product type r : regulator; sensor protein PhoQ 2058702..2060162 Escherichia coli IAI39 7152413 YP_002407978.1 CDS ECIAI39_2009 NC_011750.1 2060694 2060975 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2060694..2060975) Escherichia coli IAI39 7152414 YP_002407979.1 CDS ECIAI39_2010 NC_011750.1 2060989 2062650 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage terminase large subunit complement(2060989..2062650) Escherichia coli IAI39 7149932 YP_002407980.1 CDS ECIAI39_2011 NC_011750.1 2062634 2062990 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage terminase, small subunit complement(2062634..2062990) Escherichia coli IAI39 7149933 YP_002407981.1 CDS ECIAI39_2012 NC_011750.1 2063279 2063719 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; putative endonuclease complement(2063279..2063719) Escherichia coli IAI39 7149934 YP_002407982.1 CDS ECIAI39_2013 NC_011750.1 2063719 2064015 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2063719..2064015) Escherichia coli IAI39 7149935 YP_002407983.1 CDS ECIAI39_2014 NC_011750.1 2064012 2064350 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head-tail adaptor complement(2064012..2064350) Escherichia coli IAI39 7149936 YP_002407984.1 CDS ECIAI39_2015 NC_011750.1 2064347 2065561 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head portal protein complement(2064347..2065561) Escherichia coli IAI39 7149937 YP_002407985.1 CDS ECIAI39_2016 NC_011750.1 2065563 2066138 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head maturation protease of prophage complement(2065563..2066138) Escherichia coli IAI39 7149938 YP_002407986.1 CDS ECIAI39_2017 NC_011750.1 2066174 2067346 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative major capsid protein of prophage complement(2066174..2067346) Escherichia coli IAI39 7149939 YP_002407987.1 CDS ECIAI39_2018 NC_011750.1 2067916 2068326 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative single stranded DNA-binding protein of prophage complement(2067916..2068326) Escherichia coli IAI39 7149940 YP_002407988.1 CDS ECIAI39_2019 NC_011750.1 2068323 2068580 R hypothetical protein complement(2068323..2068580) Escherichia coli IAI39 7149941 YP_002407989.1 CDS ECIAI39_2020 NC_011750.1 2068869 2070617 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; nucleic acid independent nucleoside triphosphatase; phage DNA primase complement(2068869..2070617) Escherichia coli IAI39 7149942 YP_002407990.1 CDS ECIAI39_2021 NC_011750.1 2070614 2070913 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2070614..2070913) Escherichia coli IAI39 7149943 YP_002407991.1 CDS ECIAI39_2023 NC_011750.1 2071139 2071603 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2071139..2071603) Escherichia coli IAI39 7149944 YP_002407992.1 CDS ECIAI39_2024 NC_011750.1 2071596 2072657 R hypothetical protein complement(2071596..2072657) Escherichia coli IAI39 7150890 YP_002407993.1 CDS ECIAI39_2026 NC_011750.1 2072715 2072903 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage regulatory protein complement(2072715..2072903) Escherichia coli IAI39 7149946 YP_002407994.1 CDS int NC_011750.1 2073278 2074528 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; integrase of prophage complement(2073278..2074528) Escherichia coli IAI39 7149947 YP_002407995.1 CDS ycfD NC_011750.1 2074756 2075877 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2074756..2075877 Escherichia coli IAI39 7151829 YP_002407996.1 CDS pepT NC_011750.1 2076023 2077105 R catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T complement(2076023..2077105) Escherichia coli IAI39 7153449 YP_002407997.1 CDS ECIAI39_2030 NC_011750.1 2077162 2077488 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 2077162..2077488 Escherichia coli IAI39 7152368 YP_002407998.1 CDS ECIAI39_2031 NC_011750.1 2077485 2077967 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 2077485..2077967 Escherichia coli IAI39 7149948 YP_002407999.1 CDS ECIAI39_2032 NC_011750.1 2078559 2080082 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative reverse transcriptase-like protein from putative prophage or plasmid 2078559..2080082 Escherichia coli IAI39 7149949 YP_002408000.1 CDS ECIAI39_2033 NC_011750.1 2080199 2080645 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 2080199..2080645 Escherichia coli IAI39 7150535 YP_002408001.1 CDS potA NC_011750.1 2081085 2082221 D functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase protein 2081085..2082221 Escherichia coli IAI39 7149951 YP_002408002.1 CDS potB NC_011750.1 2082235 2083062 D can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein 2082235..2083062 Escherichia coli IAI39 7152441 YP_002408003.1 CDS potC NC_011750.1 2083059 2083853 D can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein 2083059..2083853 Escherichia coli IAI39 7152442 YP_002408004.1 CDS potD NC_011750.1 2083850 2084896 D can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter periplasmic substrate-binding protein 2083850..2084896 Escherichia coli IAI39 7152443 YP_002408005.1 CDS ymfA NC_011750.1 2084954 2085415 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2084954..2085415 Escherichia coli IAI39 7152444 YP_002408006.1 CDS ycfZ NC_011750.1 2085412 2086200 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2085412..2086200 Escherichia coli IAI39 7154384 YP_002408007.1 CDS cobB NC_011750.1 2086338 2087159 R Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase complement(2086338..2087159) Escherichia coli IAI39 7153461 YP_002408008.1 CDS ycfX NC_011750.1 2087175 2088086 R catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase complement(2087175..2088086) Escherichia coli IAI39 7150976 YP_002408009.1 CDS lolE NC_011750.1 2088115 2089359 R part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE complement(2088115..2089359) Escherichia coli IAI39 7153460 YP_002408010.1 CDS lolD NC_011750.1 2089359 2090060 R outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding subunit complement(2089359..2090060) Escherichia coli IAI39 7151954 YP_002408011.1 CDS lolC NC_011750.1 2090053 2091252 R part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC complement(2090053..2091252) Escherichia coli IAI39 7151953 YP_002408012.1 CDS ycfT NC_011750.1 2091514 2092587 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2091514..2092587 Escherichia coli IAI39 7151952 YP_002408013.1 CDS mfd NC_011750.1 2092715 2096161 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14602898, 90158497, 92107993, 8465200; Product type f : factor; transcription-repair coupling factor 2092715..2096161 Escherichia coli IAI39 7153459 YP_002408014.1 CDS ycfS NC_011750.1 2096304 2097266 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2096304..2097266 Escherichia coli IAI39 7152064 YP_002408015.1 CDS ycfR NC_011750.1 2097349 2097606 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089; hypothetical protein complement(2097349..2097606) Escherichia coli IAI39 7153458 YP_002408016.1 CDS ycfQ NC_011750.1 2097847 2098479 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2097847..2098479 Escherichia coli IAI39 7153457 YP_002408017.1 CDS ycfJ NC_011750.1 2098541 2099080 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6265208, 7984428; hypothetical protein complement(2098541..2099080) Escherichia coli IAI39 7153456 YP_002408018.1 CDS ndh NC_011750.1 2099307 2100611 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14766919, 20130027, 81256452, 92296775, 94042945, 99441207, 6265208; Product type e : enzyme; respiratory NADH dehydrogenase 2/cupric reductase complement(2099307..2100611) Escherichia coli IAI39 7153451 YP_002408019.1 CDS ycfP NC_011750.1 2101011 2101553 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2101011..2101553) Escherichia coli IAI39 7152202 YP_002408020.1 CDS nagZ NC_011750.1 2101576 2102601 R hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase complement(2101576..2102601) Escherichia coli IAI39 7153455 YP_002408021.1 CDS thiK NC_011750.1 2102612 2103436 R catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase complement(2102612..2103436) Escherichia coli IAI39 7152176 YP_002408022.1 CDS ycfM NC_011750.1 2103417 2104058 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein complement(2103417..2104058) Escherichia coli IAI39 7153454 YP_002408023.1 CDS ycfL NC_011750.1 2104072 2104449 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2104072..2104449) Escherichia coli IAI39 7153453 YP_002408024.1 CDS hinT NC_011750.1 2104452 2104811 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15703176, 10493123, 2162465; Product type e : enzyme; purine nucleoside phosphoramidase complement(2104452..2104811) Escherichia coli IAI39 7153452 YP_002408025.1 CDS ptsG NC_011750.1 2107394 2108827 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunits IIBC complement(2107394..2108827) Escherichia coli IAI39 7151319 YP_002408026.1 CDS ycfH NC_011750.1 2109122 2109919 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8505303, 8509334, 10747959; Product type pe : putative enzyme; putative metallodependent hydrolase complement(2109122..2109919) Escherichia coli IAI39 7152518 YP_002408027.1 CDS holB NC_011750.1 2109930 2110934 R catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' complement(2109930..2110934) Escherichia coli IAI39 7153450 YP_002408028.1 CDS tmk NC_011750.1 2110931 2111572 R catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase complement(2110931..2111572) Escherichia coli IAI39 7151668 YP_002408029.1 CDS yceG NC_011750.1 2111562 2112584 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein complement(2111562..2112584) Escherichia coli IAI39 7152992 YP_002408030.1 CDS pabC NC_011750.1 2112587 2113396 R catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase complement(2112587..2113396) Escherichia coli IAI39 7153443 YP_002408031.1 CDS fabF NC_011750.1 2113516 2114757 R FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II complement(2113516..2114757) Escherichia coli IAI39 7152321 YP_002408032.1 CDS acpP NC_011750.1 2114845 2115081 R carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein complement(2114845..2115081) Escherichia coli IAI39 7151266 YP_002408033.1 CDS fabG NC_011750.1 2115292 2116026 R catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase complement(2115292..2116026) Escherichia coli IAI39 7150669 YP_002408034.1 CDS fabD NC_011750.1 2116039 2116968 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92052166, 92183950, 92210530, 92234941, 7700236, 7768883, 9298646; Product type e : enzyme; malonyl-CoA-[acyl-carrier-protein] transacylase complement(2116039..2116968) Escherichia coli IAI39 7151267 YP_002408035.1 CDS fabH NC_011750.1 2116984 2117937 R FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III complement(2116984..2117937) Escherichia coli IAI39 7151265 YP_002408036.1 CDS plsX NC_011750.1 2118005 2119075 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX complement(2118005..2119075) Escherichia coli IAI39 7151268 YP_002408037.1 CDS rpmF NC_011750.1 2119156 2119329 R some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 complement(2119156..2119329) Escherichia coli IAI39 7152429 YP_002408038.1 CDS yceD NC_011750.1 2119381 2119902 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 90008815, 1447160; hypothetical protein complement(2119381..2119902) Escherichia coli IAI39 7152699 YP_002408039.1 CDS yceF NC_011750.1 2120101 2120685 D Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 2120101..2120685 Escherichia coli IAI39 7152893 YP_002408040.1 CDS rluC NC_011750.1 2120797 2121756 R catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C complement(2120797..2121756) Escherichia coli IAI39 7153442 YP_002408041.1 CDS rne NC_011750.1 2122329 2125514 D bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E 2122329..2125514 Escherichia coli IAI39 7150536 YP_002408042.1 CDS ECIAI39_2077 NC_011750.1 2125603 2125941 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2125603..2125941 Escherichia coli IAI39 7152656 YP_002408043.1 CDS ECIAI39_2078 NC_011750.1 2125923 2126432 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2125923..2126432 Escherichia coli IAI39 7149952 YP_002408044.1 CDS flgL NC_011750.1 2126527 2127480 R with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; flagellar hook-associated protein FlgL complement(2126527..2127480) Escherichia coli IAI39 7149953 YP_002408045.1 CDS flgK NC_011750.1 2127492 2129135 R with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK complement(2127492..2129135) Escherichia coli IAI39 7151361 YP_002408046.1 CDS flgJ NC_011750.1 2129201 2130142 R Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ complement(2129201..2130142) Escherichia coli IAI39 7151360 YP_002408047.1 CDS flgH NC_011750.1 2131251 2131949 R part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein complement(2131251..2131949) Escherichia coli IAI39 7151358 YP_002408048.1 CDS flgG NC_011750.1 2132002 2132784 R makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG complement(2132002..2132784) Escherichia coli IAI39 7151356 YP_002408049.1 CDS flgF NC_011750.1 2132921 2133676 R FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF complement(2132921..2133676) Escherichia coli IAI39 7151355 YP_002408050.1 CDS flgE NC_011750.1 2133696 2134898 R the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE complement(2133696..2134898) Escherichia coli IAI39 7151354 YP_002408051.1 CDS flgD NC_011750.1 2134923 2135618 R acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein complement(2134923..2135618) Escherichia coli IAI39 7151353 YP_002408052.1 CDS flgC NC_011750.1 2135630 2136034 R with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC complement(2135630..2136034) Escherichia coli IAI39 7151352 YP_002408053.1 CDS flgB NC_011750.1 2136038 2136454 R with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal body rod protein FlgB complement(2136038..2136454) Escherichia coli IAI39 7151351 YP_002408054.1 CDS flgA NC_011750.1 2136609 2137268 D required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA 2136609..2137268 Escherichia coli IAI39 7151350 YP_002408055.1 CDS flgM NC_011750.1 2137344 2137634 D regulates the flagellar specific sigma28 transcription factor; anti-sigma28 factor FlgM 2137344..2137634 Escherichia coli IAI39 7151349 YP_002408056.1 CDS flgN NC_011750.1 2137639 2138055 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10320579; Product type f : factor; export chaperone for FlgK and FlgL 2137639..2138055 Escherichia coli IAI39 7151362 YP_002408057.1 CDS mviN NC_011750.1 2138095 2139630 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2138095..2139630) Escherichia coli IAI39 7151363 YP_002408058.1 CDS mviM NC_011750.1 2139740 2140663 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(2139740..2140663) Escherichia coli IAI39 7152162 YP_002408059.1 CDS yceH NC_011750.1 2140665 2141312 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1356970, 2828880; hypothetical protein complement(2140665..2141312) Escherichia coli IAI39 7152161 YP_002408060.1 CDS rimJ NC_011750.1 2141323 2141907 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88121676, 90136529, 1356970; Product type e : enzyme; ribosomal-protein-S5-alanine N-acetyltransferase complement(2141323..2141907) Escherichia coli IAI39 7153444 YP_002408061.1 CDS mdtH NC_011750.1 2142143 2143351 D Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH 2142143..2143351 Escherichia coli IAI39 7152635 YP_002408062.1 CDS grxB NC_011750.1 2143415 2144062 D cofactor involved in the reduction of disulfides; glutaredoxin 2 2143415..2144062 Escherichia coli IAI39 7152035 YP_002408063.1 CDS yceB NC_011750.1 2144196 2144756 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 2144196..2144756 Escherichia coli IAI39 7151589 YP_002408064.1 CDS pyrC NC_011750.1 2144862 2145908 D catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 2144862..2145908 Escherichia coli IAI39 7153440 YP_002408065.2 CDS dinI NC_011750.1 2145982 2146227 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11230150, 11152126; Product type f : factor; DNA damage-inducible protein I 2145982..2146227 Escherichia coli IAI39 7152549 YP_002408066.1 CDS bssS NC_011750.1 2146517 2146771 D BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS 2146517..2146771 Escherichia coli IAI39 7151141 YP_002408067.1 CDS solA NC_011750.1 2146886 2148004 D catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase 2146886..2148004 Escherichia coli IAI39 7150877 YP_002408068.1 CDS yceO NC_011750.1 2148025 2148165 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2148025..2148165 Escherichia coli IAI39 7152876 YP_002408069.1 CDS yceJ NC_011750.1 2148426 2148992 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative cytochrome b561 2148426..2148992 Escherichia coli IAI39 7153448 YP_002408070.1 CDS ECIAI39_2107 NC_011750.1 2148759 2148926 R hypothetical protein complement(2148759..2148926) Escherichia coli IAI39 7153446 YP_002408071.1 CDS yceI NC_011750.1 2148996 2149571 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15741337, 11298273, 1840644, 9298646; Product type c : carrier; hypothetical protein 2148996..2149571 Escherichia coli IAI39 7149954 YP_002408072.1 CDS yceA NC_011750.1 2149613 2150665 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1840644; hypothetical protein complement(2149613..2150665) Escherichia coli IAI39 7153445 YP_002408073.1 CDS lpxL NC_011750.1 2150890 2151810 D Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 2150890..2151810 Escherichia coli IAI39 7153439 YP_002408074.1 CDS mdtG NC_011750.1 2151982 2153208 D Confers resistance to fosfomycin and deoxycholate; drug efflux system protein MdtG 2151982..2153208 Escherichia coli IAI39 7151971 YP_002408075.1 CDS msyB NC_011750.1 2153291 2153665 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 92165719; hypothetical protein 2153291..2153665 Escherichia coli IAI39 7152034 YP_002408076.1 CDS yceK NC_011750.1 2153666 2153893 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein complement(2153666..2153893) Escherichia coli IAI39 7152136 YP_002408077.1 CDS mdoH NC_011750.1 2154098 2156641 R necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH complement(2154098..2156641) Escherichia coli IAI39 7153447 YP_002408078.1 CDS mdoG NC_011750.1 2156634 2158169 R involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G complement(2156634..2158169) Escherichia coli IAI39 7152027 YP_002408079.1 CDS mdoC NC_011750.1 2158563 2159720 D required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein 2158563..2159720 Escherichia coli IAI39 7152026 YP_002408080.1 CDS ymdC NC_011750.1 2159728 2161149 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase complement(2159728..2161149) Escherichia coli IAI39 7152025 YP_002408081.1 CDS ymdB NC_011750.1 2161151 2161684 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2161151..2161684) Escherichia coli IAI39 7154383 YP_002408082.1 CDS ymdA NC_011750.1 2161779 2162090 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2161779..2162090) Escherichia coli IAI39 7154382 YP_002408083.1 CDS csgC NC_011750.1 2162211 2162543 R involved in autoagglutination of curliated cells; not involved in production of curli fibers; putative autoagglutination protein complement(2162211..2162543) Escherichia coli IAI39 7154381 YP_002408084.1 CDS csgA NC_011750.1 2162602 2163057 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89201357, 93023873, 1677357, 8459772, 8817489, 1357528; Product type s : structure; cryptic curlin major subunit complement(2162602..2163057) Escherichia coli IAI39 7151005 YP_002408085.1 CDS csgB NC_011750.1 2163098 2163553 R CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit complement(2163098..2163553) Escherichia coli IAI39 7151003 YP_002408086.1 CDS csgD NC_011750.1 2164308 2164958 D activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD 2164308..2164958 Escherichia coli IAI39 7151004 YP_002408087.1 CDS csgE NC_011750.1 2164963 2165352 D chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE 2164963..2165352 Escherichia coli IAI39 7151006 YP_002408088.1 CDS csgF NC_011750.1 2165377 2165793 D nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF 2165377..2165793 Escherichia coli IAI39 7151007 YP_002408089.1 CDS csgG NC_011750.1 2165820 2166653 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8817489; Product type lp : lipoprotein; putative outer membrane lipoprotein involved in curli production assembly/transport 2165820..2166653 Escherichia coli IAI39 7151008 YP_002408090.1 CDS ycdZ NC_011750.1 2166717 2167208 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2166717..2167208) Escherichia coli IAI39 7151009 YP_002408091.1 CDS ycdY NC_011750.1 2167310 2167864 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2167310..2167864) Escherichia coli IAI39 7153438 YP_002408092.1 CDS ycdX NC_011750.1 2167888 2168625 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12661000; Product type pe : putative enzyme; putative hydrolase complement(2167888..2168625) Escherichia coli IAI39 7153437 YP_002408093.1 CDS ycdW NC_011750.1 2168680 2169618 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11237876, 10493123; Product type e : enzyme; 2-ketoacid reductase complement(2168680..2169618) Escherichia coli IAI39 7153436 YP_002408094.1 CDS ycdT NC_011750.1 2170044 2171501 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 99392474; Product type pe : putative enzyme; putative diguanylate cyclase complement(2170044..2171501) Escherichia coli IAI39 7150556 YP_002408095.1 CDS pgaA NC_011750.1 2172001 2174424 D outer membrane protein essential for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PGA); adhesin required for biofilm formation; PgaA (HmsH) seems to translocate and/or dock PGA to the cell surface; member of the hmsHFRS (ycdSRQP or pgaABCD in Escherichia coli) operon in Yersinia; outer membrane protein PgaA 2172001..2174424 Escherichia coli IAI39 7153434 YP_002408096.1 CDS pgaB NC_011750.1 2174433 2176451 D in Yersinia this protein is involved in biofilm formation and hemin adsorption; related protein PgaB in Escherichia coli is an outer membrane N-deacetylase involved in poly-beta-1,6-N-acetyl-D-glucosamine (PGA) export; outer membrane N-deacetylase 2174433..2176451 Escherichia coli IAI39 7152377 YP_002408097.1 CDS pgaC NC_011750.1 2176444 2177718 D predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein; N-glycosyltransferase 2176444..2177718 Escherichia coli IAI39 7152378 YP_002408098.1 CDS pgaD NC_011750.1 2177772 2178185 D in Yersinia this gene is involved in biofilm formation and hemin adsorption; in Escherichia coli it is involved in PGA biosynthesis and export; putative PGA biosynthesis protein 2177772..2178185 Escherichia coli IAI39 7152379 YP_002408099.1 CDS phoH NC_011750.1 2178235 2179299 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8444794, 2160940; Product type pe : putative enzyme; hypothetical protein complement(2178235..2179299) Escherichia coli IAI39 7152380 YP_002408100.1 CDS efeB NC_011750.1 2179544 2180815 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17627767, 16551627, 15375152; Product type t : transporter; iron transport heme-binding periplasmic protein complement(2179544..2180815) Escherichia coli IAI39 7152412 YP_002408101.1 CDS efeO NC_011750.1 2180821 2181948 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17627767, 10493123; Product type t : transporter; hypothetical protein complement(2180821..2181948) Escherichia coli IAI39 7151204 YP_002408102.1 CDS efeU NC_011750.1 2182006 2182845 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter; ferrous iron permease complement(2182006..2182845) Escherichia coli IAI39 7151205 YP_002408103.1 CDS putP NC_011750.1 2183056 2184564 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12923181, 88213396, 91227628, 93132799, 98359785, 1400239, 1567896, 3053649, 3053687, 3302614, 3325781, 8119910; Product type t : transporter; proline:sodium symporter complement(2183056..2184564) Escherichia coli IAI39 7151206 YP_002408104.1 CDS putA NC_011750.1 2184987 2188949 D proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein; trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 2184987..2188949 Escherichia coli IAI39 7152538 YP_002408105.1 CDS rutR NC_011750.1 2188989 2189627 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type r : regulator; alternative pyrimidine degradation pathway DNA-binding transcriptional regulator complement(2188989..2189627) Escherichia coli IAI39 7152537 YP_002408106.1 CDS rutA NC_011750.1 2189825 2190820 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; alternative pyrimidine degradation pathway monooxygenase 2189825..2190820 Escherichia coli IAI39 7152772 YP_002408107.1 CDS rutB NC_011750.1 2190867 2191559 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; alternative pyrimidine degradation pathway protein 2190867..2191559 Escherichia coli IAI39 7152765 YP_002408108.1 CDS rutC NC_011750.1 2191571 2191957 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; alternative pyrimidine degradation pathway protein 2191571..2191957 Escherichia coli IAI39 7152766 YP_002408109.1 CDS rutD NC_011750.1 2191965 2192765 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; alternative pyrimidine degradation pathway protein 2191965..2192765 Escherichia coli IAI39 7152767 YP_002408110.1 CDS rutE NC_011750.1 2192775 2193365 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; hypothetical protein 2192775..2193365 Escherichia coli IAI39 7152768 YP_002408111.1 CDS rutF NC_011750.1 2193376 2193870 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542, 10633095; Product type e : enzyme; alternative pyrimidine degradation pathway flavin:NADH oxidoreductase subunit 2193376..2193870 Escherichia coli IAI39 7152769 YP_002408112.1 CDS rutG NC_011750.1 2193891 2195219 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type t : transporter; pyrimidine transporter 2193891..2195219 Escherichia coli IAI39 7152770 YP_002408113.1 CDS wrbA NC_011750.1 2195848 2196444 D stationary phase protein that binds TrpR repressor; TrpR binding protein WrbA 2195848..2196444 Escherichia coli IAI39 7152771 YP_002408114.1 CDS yccJ NC_011750.1 2196465 2196692 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2196465..2196692 Escherichia coli IAI39 7153161 YP_002408115.1 CDS agp NC_011750.1 2196730 2197971 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12455612, 90368616, 91297199, 2153660, 9298646; Product type e : enzyme; glucose-1-phosphatase/inositol phosphatase complement(2196730..2197971) Escherichia coli IAI39 7153425 YP_002408116.1 CDS yccE NC_011750.1 2198264 2199520 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8302830; hypothetical protein complement(2198264..2199520) Escherichia coli IAI39 7150705 YP_002408117.1 CDS cbpA NC_011750.1 2199780 2200700 D functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA 2199780..2200700 Escherichia coli IAI39 7153423 YP_002408118.1 CDS cbpM NC_011750.1 2200700 2201005 D with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM 2200700..2201005 Escherichia coli IAI39 7150905 YP_002408119.1 CDS torD NC_011750.1 2201157 2201756 R TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; chaperone protein TorD complement(2201157..2201756) Escherichia coli IAI39 7150906 YP_002408120.1 CDS torA NC_011750.1 2201753 2204299 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88193091, 90089471, 94293785, 8302830, 8022286; Product type e : enzyme; trimethylamine N-oxide (TMAO) reductase I, catalytic subunit complement(2201753..2204299) Escherichia coli IAI39 7153006 YP_002408121.1 CDS torC NC_011750.1 2204299 2205471 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293785, 94314186, 99340208, 11056172, 11562502; Product type c : carrier; trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit complement(2204299..2205471) Escherichia coli IAI39 7153004 YP_002408122.1 CDS torR NC_011750.1 2205601 2206293 D response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR 2205601..2206293 Escherichia coli IAI39 7153005 YP_002408123.1 CDS torT NC_011750.1 2206266 2207294 R periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT complement(2206266..2207294) Escherichia coli IAI39 7153007 YP_002408124.1 CDS torS NC_011750.1 2207377 2210121 D Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide; hybrid sensory histidine kinase TorS 2207377..2210121 Escherichia coli IAI39 7153009 YP_002408125.1 CDS yccM NC_011750.1 2210193 2211266 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S membrane protein 2210193..2211266 Escherichia coli IAI39 7153008 YP_002408126.1 CDS gnsA NC_011750.1 2211315 2211488 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15317805, 11544213; Product type pr : putative regulator; putative regulator of phosphatidylethanolamine synthesis complement(2211315..2211488) Escherichia coli IAI39 7153426 YP_002408127.1 CDS cspG NC_011750.1 2211882 2212094 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9484881, 15466053, 8631696, 9439003; Product type r : regulator; cold shock protein CspG complement(2211882..2212094) Escherichia coli IAI39 7151567 YP_002408128.1 CDS cspH NC_011750.1 2212380 2212592 D Evidence 2b : Function of strongly homologous gene; PubMedId : 9484881, 9439003; Product type f : factor; stress protein, member of the CspA-family 2212380..2212592 Escherichia coli IAI39 7151018 YP_002408129.1 CDS appA NC_011750.1 2212580 2213878 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20122624, 92049231, 93054596, 10696472, 2168385, 3038201, 8387749; Product type e : enzyme; phosphoanhydride phosphorylase complement(2212580..2213878) Escherichia coli IAI39 7151019 YP_002408130.1 CDS appB NC_011750.1 2214075 2215211 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92049231, 96198179; Product type c : carrier; cytochrome bd-II oxidase subunit II complement(2214075..2215211) Escherichia coli IAI39 7150742 YP_002408131.1 CDS appC NC_011750.1 2215223 2216767 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92049231, 96198179; Product type c : carrier; cytochrome bd-II oxidase subunit I complement(2215223..2216767) Escherichia coli IAI39 7150743 YP_002408132.1 CDS hyaF NC_011750.1 2216901 2217758 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202716, 91310595, 92215587; Product type f : factor; hydrogenase-1 nickel incorportation protein complement(2216901..2217758) Escherichia coli IAI39 7150744 YP_002408133.1 CDS hyaE NC_011750.1 2217755 2218153 R involved in processing hydrogenase proteins HyaA and HyaB; hydrogenase-1 operon protein HyaE complement(2217755..2218153) Escherichia coli IAI39 7151702 YP_002408134.1 CDS hyaD NC_011750.1 2218150 2218737 R HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease complement(2218150..2218737) Escherichia coli IAI39 7151701 YP_002408135.1 CDS hyaC NC_011750.1 2218734 2219441 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202716, 91310595, 92215587; Product type c : carrier; hydrogenase 1 b-type cytochrome subunit complement(2218734..2219441) Escherichia coli IAI39 7151700 YP_002408136.1 CDS hyaB NC_011750.1 2219460 2221253 R involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit complement(2219460..2221253) Escherichia coli IAI39 7151699 YP_002408137.1 CDS hyaA NC_011750.1 2221250 2222368 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86192450, 90202716, 92215587; Product type e : enzyme; hydrogenase 1, small subunit complement(2221250..2222368) Escherichia coli IAI39 7151698 YP_002408138.1 CDS yccA NC_011750.1 2223089 2223748 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6376117; Product type m : membrane component; hypothetical protein 2223089..2223748 Escherichia coli IAI39 7150557 YP_002408139.1 CDS tusE NC_011750.1 2223840 2224169 D transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE 2223840..2224169 Escherichia coli IAI39 7153422 YP_002408140.1 CDS yccX NC_011750.1 2224166 2224657 R catalyzes the hydrolysis of acylphosphate; acylphosphatase complement(2224166..2224657) Escherichia coli IAI39 7153061 YP_002408141.1 CDS yccW NC_011750.1 2224626 2225729 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative AdoMet-dependent methyltransferase 2224626..2225729 Escherichia coli IAI39 7153433 YP_002408142.1 CDS yccV NC_011750.1 2225787 2226104 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12700277, 15569148; Product type f : factor; heat shock protein HspQ 2225787..2226104 Escherichia coli IAI39 7153432 YP_002408143.1 CDS yccU NC_011750.1 2226149 2226562 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative CoA-binding protein complement(2226149..2226562) Escherichia coli IAI39 7153431 YP_002408144.1 CDS ECIAI39_2181 NC_011750.1 2226525 2226695 D hypothetical protein 2226525..2226695 Escherichia coli IAI39 7153430 YP_002408145.1 CDS yccT NC_011750.1 2226735 2227397 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2226735..2227397 Escherichia coli IAI39 7149955 YP_002408146.1 CDS mgsA NC_011750.1 2227493 2227951 D catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 2227493..2227951 Escherichia coli IAI39 7153429 YP_002408147.1 CDS helD NC_011750.1 2227983 2230037 R catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV complement(2227983..2230037) Escherichia coli IAI39 7152068 YP_002408148.1 CDS yccF NC_011750.1 2230160 2230606 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2230160..2230606 Escherichia coli IAI39 7151623 YP_002408149.1 CDS yccS NC_011750.1 2230625 2232778 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2230625..2232778 Escherichia coli IAI39 7153424 YP_002408150.1 CDS yccR NC_011750.1 2232741 2233370 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2232741..2233370) Escherichia coli IAI39 7153428 YP_002408151.1 CDS sulA NC_011750.1 2233588 2234097 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10368140, 91072263, 93163041, 98348458, 3297925, 6253901, 6306396; Product type cp : cell process; SOS cell division inhibitor 2233588..2234097 Escherichia coli IAI39 7153427 YP_002408152.1 CDS ECIAI39_2189 NC_011750.1 2234081 2234299 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2234081..2234299) Escherichia coli IAI39 7151850 YP_002408153.1 CDS ompA NC_011750.1 2234382 2235506 D OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein A 2234382..2235506 Escherichia coli IAI39 7149956 YP_002408154.1 CDS ycbG NC_011750.1 2235583 2236035 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2235583..2236035) Escherichia coli IAI39 7152290 YP_002408155.1 CDS ycbZ NC_011750.1 2236221 2237981 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATP-dependent protease 2236221..2237981 Escherichia coli IAI39 7153408 YP_002408156.1 CDS fabA NC_011750.1 2238050 2238568 D catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-(acyl carrier protein) dehydratase 2238050..2238568 Escherichia coli IAI39 7153421 YP_002408157.1 CDS rmf NC_011750.1 2238638 2238805 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1101029, 90207255, 2832401, 8440252; Product type f : factor; ribosome modulation factor complement(2238638..2238805) Escherichia coli IAI39 7151263 YP_002408158.1 CDS ymbA NC_011750.1 2239061 2239609 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2239061..2239609) Escherichia coli IAI39 7152645 YP_002408159.1 CDS pqiB NC_011750.1 2239621 2241261 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95270582; Product type cp : cell process; paraquat-inducible protein B complement(2239621..2241261) Escherichia coli IAI39 7154380 YP_002408160.1 CDS pqiA NC_011750.1 2241266 2242519 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95270582; Product type cp : cell process; paraquat-inducible membrane protein A complement(2241266..2242519) Escherichia coli IAI39 7152469 YP_002408161.1 CDS uup NC_011750.1 2242649 2244556 R Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase complement(2242649..2244556) Escherichia coli IAI39 7152468 YP_002408162.1 CDS rlmL NC_011750.1 2244568 2246676 R catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase complement(2244568..2246676) Escherichia coli IAI39 7153112 YP_002408163.1 CDS ycbX NC_011750.1 2246774 2247883 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1327782; Product type pe : putative enzyme; putative 2Fe-2S cluster-containing protein 2246774..2247883 Escherichia coli IAI39 7153420 YP_002408164.1 CDS ycbW NC_011750.1 2247880 2248422 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2247880..2248422) Escherichia coli IAI39 7153419 YP_002408165.1 CDS pyrD NC_011750.1 2248596 2249606 R catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 complement(2248596..2249606) Escherichia coli IAI39 7153418 YP_002408166.1 CDS ycbF NC_011750.1 2249717 2250427 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putativi pili assembly chaperone complement(2249717..2250427) Escherichia coli IAI39 7152550 YP_002408167.1 CDS ycbV NC_011750.1 2250420 2250935 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative exported fimbrial-like adhesin protein complement(2250420..2250935) Escherichia coli IAI39 7153407 YP_002408168.1 CDS ycbU NC_011750.1 2250943 2251485 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin protein complement(2250943..2251485) Escherichia coli IAI39 7153417 YP_002408169.1 CDS ycbT NC_011750.1 2251497 2252567 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7721701; Product type ps : putative structure; putative fimbrial-like adhesin protein complement(2251497..2252567) Escherichia coli IAI39 7153416 YP_002408170.1 CDS ycbS NC_011750.1 2252558 2255158 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative outer membrane export usher protein complement(2252558..2255158) Escherichia coli IAI39 7153415 YP_002408171.1 CDS ycbR NC_011750.1 2255183 2255884 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative periplasmic pilin chaperone complement(2255183..2255884) Escherichia coli IAI39 7153414 YP_002408172.1 CDS ycbQ NC_011750.1 2255965 2256504 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type ps : putative structure; putative fimbrial-like adhesin protein complement(2255965..2256504) Escherichia coli IAI39 7153413 YP_002408173.1 CDS ssuE NC_011750.1 2256860 2257435 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20245523, 99410391, 99436146, 8774726; Product type e : enzyme; NAD(P)H-dependent FMN reductase 2256860..2257435 Escherichia coli IAI39 7153412 YP_002408174.1 CDS ssuA NC_011750.1 2257428 2258387 D part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit 2257428..2258387 Escherichia coli IAI39 7152915 YP_002408175.1 CDS ssuD NC_011750.1 2258384 2259529 D catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase 2258384..2259529 Escherichia coli IAI39 7152911 YP_002408176.1 CDS ssuC NC_011750.1 2259541 2260332 D part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter permease subunit 2259541..2260332 Escherichia coli IAI39 7152914 YP_002408177.1 CDS ssuB NC_011750.1 2260329 2261096 D part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease; aliphatic sulfonates transport ATP-binding subunit 2260329..2261096 Escherichia coli IAI39 7152913 YP_002408178.1 CDS pepN NC_011750.1 2261139 2263751 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101837, 86164315, 87163509, 2436977, 3018440; Product type e : enzyme; aminopeptidase N complement(2261139..2263751) Escherichia coli IAI39 7152912 YP_002408179.1 CDS pncB NC_011750.1 2264017 2265219 D catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 2264017..2265219 Escherichia coli IAI39 7152365 YP_002408180.1 CDS asnC NC_011750.1 2265388 2266788 D catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 2265388..2266788 Escherichia coli IAI39 7152434 YP_002408181.1 CDS ompF NC_011750.1 2267390 2268463 D outer membrane porin F; 1a; Ia; b; outer membrane protein F 2267390..2268463 Escherichia coli IAI39 7150805 YP_002408182.1 CDS aspC NC_011750.1 2268648 2269838 D catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 2268648..2269838 Escherichia coli IAI39 7152292 YP_002408183.1 CDS ycbL NC_011750.1 2269888 2270535 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14529289; Product type pe : putative enzyme; putative metal-binding hydrolase complement(2269888..2270535) Escherichia coli IAI39 7150807 YP_002408184.1 CDS ycbK NC_011750.1 2270562 2271110 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2270562..2271110) Escherichia coli IAI39 7153411 YP_002408185.1 CDS ycbB NC_011750.1 2271291 2273138 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(2271291..2273138) Escherichia coli IAI39 7153410 YP_002408186.1 CDS mukB NC_011750.1 2273399 2277859 R SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB complement(2273399..2277859) Escherichia coli IAI39 7153405 YP_002408187.1 CDS mukE NC_011750.1 2277859 2278536 R acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E complement(2277859..2278536) Escherichia coli IAI39 7152142 YP_002408188.1 CDS mukF NC_011750.1 2278544 2279866 R acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F complement(2278544..2279866) Escherichia coli IAI39 7152143 YP_002408189.1 CDS smtA NC_011750.1 2279863 2280648 R involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; putative metallothionein SmtA complement(2279863..2280648) Escherichia coli IAI39 7152144 YP_002408190.1 CDS ycbC NC_011750.1 2280784 2281563 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2280784..2281563 Escherichia coli IAI39 7152869 YP_002408191.1 CDS ycbJ NC_011750.1 2281540 2282433 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2281540..2282433) Escherichia coli IAI39 7153406 YP_002408192.1 CDS kdsB NC_011750.1 2282587 2283333 R CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase complement(2282587..2283333) Escherichia coli IAI39 7153409 YP_002408193.1 CDS ycaR NC_011750.1 2283330 2283512 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2283330..2283512) Escherichia coli IAI39 7151886 YP_002408194.1 CDS ycaQ NC_011750.1 2283564 2284796 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2283564..2284796) Escherichia coli IAI39 7153404 YP_002408195.1 CDS lpxK NC_011750.1 2284833 2285819 R transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase complement(2284833..2285819) Escherichia coli IAI39 7153403 YP_002408196.1 CDS msbA NC_011750.1 2285816 2287564 R involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease complement(2285816..2287564) Escherichia coli IAI39 7151970 YP_002408197.1 CDS ycaI NC_011750.1 2287601 2289865 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2287601..2289865) Escherichia coli IAI39 7152130 YP_002408198.1 CDS ihfB NC_011750.1 2290072 2290356 R This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta complement(2290072..2290356) Escherichia coli IAI39 7153395 YP_002408199.1 CDS rpsA NC_011750.1 2290516 2292189 R in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 complement(2290516..2292189) Escherichia coli IAI39 7151761 YP_002408200.1 CDS cmk NC_011750.1 2292300 2292983 R Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase complement(2292300..2292983) Escherichia coli IAI39 7152713 YP_002408201.1 CDS ycaL NC_011750.1 2293156 2293920 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative lipoprotein with metallohydrolase domain complement(2293156..2293920) Escherichia coli IAI39 7150969 YP_002408202.1 CDS ECIAI39_2239 NC_011750.1 2294109 2295455 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase, IS4 2294109..2295455 Escherichia coli IAI39 7153398 YP_002408203.1 CDS aroA NC_011750.1 2295528 2296811 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(2295528..2296811) Escherichia coli IAI39 7149957 YP_002408204.1 CDS serC NC_011750.1 2296882 2297970 R catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase complement(2296882..2297970) Escherichia coli IAI39 7150775 YP_002408205.1 CDS ycaP NC_011750.1 2298169 2298861 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2298169..2298861) Escherichia coli IAI39 7152832 YP_002408206.1 CDS ycaO NC_011750.1 2298991 2300751 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2298991..2300751 Escherichia coli IAI39 7153402 YP_002408207.1 CDS focA NC_011750.1 2301157 2302014 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293770, 2651404; Product type t : transporter; formate transporter 2301157..2302014 Escherichia coli IAI39 7153401 YP_002408208.1 CDS pflB NC_011750.1 2302069 2304351 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91064082, 92276323, 10504733, 1310545, 2651404, 3053170, 9629924; Product type e : enzyme; pyruvate formate lyase I 2302069..2304351 Escherichia coli IAI39 7151395 YP_002408209.1 CDS pflA NC_011750.1 2304543 2305283 D activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 2304543..2305283 Escherichia coli IAI39 7152373 YP_002408210.1 CDS ycaK NC_011750.1 2305365 2305955 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3053170; Product type pe : putative enzyme; hypothetical protein complement(2305365..2305955) Escherichia coli IAI39 7152372 YP_002408211.1 CDS ycaN NC_011750.1 2306055 2306963 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2306055..2306963 Escherichia coli IAI39 7153397 YP_002408212.1 CDS ycaM NC_011750.1 2306964 2308394 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type pt : putative transporter; putative transporter complement(2306964..2308394) Escherichia coli IAI39 7153400 YP_002408213.1 CDS ycaD NC_011750.1 2308604 2309752 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative MFS family transporter protein complement(2308604..2309752) Escherichia coli IAI39 7153399 YP_002408214.1 CDS ycaC NC_011750.1 2310067 2310693 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9782055, 3062312, 11714269; Product type pe : putative enzyme; putative hydrolase 2310067..2310693 Escherichia coli IAI39 7153394 YP_002408215.1 CDS dmsC NC_011750.1 2310728 2311591 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91008971, 92011349, 3062312, 8429002; Product type e : enzyme; dimethyl sulfoxide reductase subunit C complement(2310728..2311591) Escherichia coli IAI39 7153393 YP_002408216.1 CDS dmsB NC_011750.1 2311593 2312210 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91070067, 91355180, 92011349, 3062312; Product type e : enzyme; dimethyl sulfoxide reductase subunit B complement(2311593..2312210) Escherichia coli IAI39 7151151 YP_002408217.1 CDS dmsA NC_011750.1 2312221 2314665 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91008971, 92011349, 94171715, 10801884, 3062312; Product type e : enzyme; dimethyl sulfoxide reductase subunit A complement(2312221..2314665) Escherichia coli IAI39 7151150 YP_002408218.1 CDS serS NC_011750.1 2314904 2316196 R catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase complement(2314904..2316196) Escherichia coli IAI39 7151149 YP_002408219.1 CDS ycaJ NC_011750.1 2316287 2317630 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7567469, 7628437, 11459952, 11029431; Product type cp : cell process; recombination factor protein RarA complement(2316287..2317630) Escherichia coli IAI39 7152833 YP_002408220.1 CDS lolA NC_011750.1 2317641 2318255 R participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein complement(2317641..2318255) Escherichia coli IAI39 7153396 YP_002408221.1 CDS ECIAI39_2258 NC_011750.1 2318415 2319137 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group complement(2318415..2319137) Escherichia coli IAI39 7151950 YP_002408222.1 CDS ECIAI39_2259 NC_011750.1 2319242 2319772 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 complement(2319242..2319772) Escherichia coli IAI39 7149958 YP_002408223.1 CDS ftsK NC_011750.1 2319847 2323953 R DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK complement(2319847..2323953) Escherichia coli IAI39 7149959 YP_002408224.1 CDS lrp NC_011750.1 2324088 2324582 R mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator complement(2324088..2324582) Escherichia coli IAI39 7151438 YP_002408225.1 CDS trxB NC_011750.1 2325127 2326092 D catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase 2325127..2326092 Escherichia coli IAI39 7151974 YP_002408226.1 CDS cydD NC_011750.1 2326215 2327981 D in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 2326215..2327981 Escherichia coli IAI39 7153044 YP_002408227.1 CDS cydC NC_011750.1 2327982 2329703 D in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 2327982..2329703 Escherichia coli IAI39 7151045 YP_002408228.1 CDS aat NC_011750.1 2329745 2330449 D leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase 2329745..2330449 Escherichia coli IAI39 7151044 YP_002408229.1 CDS infA NC_011750.1 2330734 2330952 D stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 2330734..2330952 Escherichia coli IAI39 7150649 YP_002408230.1 CDS ECIAI39_2267 NC_011750.1 2331418 2331822 D hypothetical protein 2331418..2331822 Escherichia coli IAI39 7150558 YP_002408231.1 CDS clpA NC_011750.1 2331879 2334155 R ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit complement(2331879..2334155) Escherichia coli IAI39 7149960 YP_002408232.1 CDS clpS NC_011750.1 2334186 2334506 R involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS complement(2334186..2334506) Escherichia coli IAI39 7150963 YP_002408233.1 CDS ECIAI39_2271 NC_011750.1 2334605 2334679 R hypothetical protein complement(2334605..2334679) Escherichia coli IAI39 7150966 YP_002408234.1 CDS cspD NC_011750.1 2334829 2335053 D inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD 2334829..2335053 Escherichia coli IAI39 7149961 YP_002408235.1 CDS macB NC_011750.1 2335126 2337072 R with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease complement(2335126..2337072) Escherichia coli IAI39 7151015 YP_002408236.1 CDS macA NC_011750.1 2337069 2338184 R confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA complement(2337069..2338184) Escherichia coli IAI39 7151992 YP_002408237.1 CDS ybjX NC_011750.1 2338299 2339291 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2338299..2339291 Escherichia coli IAI39 7151991 YP_002408238.1 CDS ybjD NC_011750.1 2339288 2340946 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2339288..2340946) Escherichia coli IAI39 7153391 YP_002408239.1 CDS aqpZ NC_011750.1 2341372 2342067 D porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z 2341372..2342067 Escherichia coli IAI39 7153375 YP_002408240.1 CDS ECIAI39_2278 NC_011750.1 2342582 2343607 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase, IS110 family complement(2342582..2343607) Escherichia coli IAI39 7150746 YP_002408241.1 CDS dusC NC_011750.1 2343838 2344785 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566; Product type e : enzyme; tRNA-dihydrouridine synthase C complement(2343838..2344785) Escherichia coli IAI39 7149962 YP_002408242.1 CDS yohJ NC_011750.1 2345024 2345422 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2345024..2345422 Escherichia coli IAI39 7151187 YP_002408243.1 CDS yohK NC_011750.1 2345419 2346114 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2345419..2346114 Escherichia coli IAI39 7154457 YP_002408244.1 CDS cdd NC_011750.1 2346244 2347128 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2346244..2347128 Escherichia coli IAI39 7154458 YP_002408245.1 CDS sanA NC_011750.1 2347278 2347997 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 96125233, 1567863, 8550448; hypothetical protein 2347278..2347997 Escherichia coli IAI39 7150920 YP_002408246.1 CDS yeiS NC_011750.1 2348000 2348239 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2348000..2348239 Escherichia coli IAI39 7152797 YP_002408247.1 CDS yeiT NC_011750.1 2348433 2349671 D function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; putative oxidoreductase 2348433..2349671 Escherichia coli IAI39 7153782 YP_002408248.1 CDS yeiA NC_011750.1 2349665 2350900 D catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines; dihydropyrimidine dehydrogenase 2349665..2350900 Escherichia coli IAI39 7153783 YP_002408249.1 CDS mglC NC_011750.1 2350971 2351981 R ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane component complement(2350971..2351981) Escherichia coli IAI39 7153767 YP_002408250.1 CDS mglA NC_011750.1 2351997 2353517 R with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein complement(2351997..2353517) Escherichia coli IAI39 7152067 YP_002408251.1 CDS mglB NC_011750.1 2353578 2354576 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87286407, 92049246, 1719366, 3057628, 3302609, 3600760, 6340108, 6885805, 7012152, 9298646; Product type t : transporter; methyl-galactoside ABC transporter subunit periplasmic-binding protein complement(2353578..2354576) Escherichia coli IAI39 7152065 YP_002408252.1 CDS galS NC_011750.1 2354856 2355896 R negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS complement(2354856..2355896) Escherichia coli IAI39 7152066 YP_002408253.1 CDS yeiB NC_011750.1 2356038 2357195 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2356038..2357195) Escherichia coli IAI39 7151476 YP_002408254.1 CDS folE NC_011750.1 2357212 2357880 R involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I complement(2357212..2357880) Escherichia coli IAI39 7153768 YP_002408255.1 CDS frmC NC_011750.1 2358138 2358974 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16567800; Product type e : enzyme; S-formylglutathione hydrolase 2358138..2358974 Escherichia coli IAI39 7151401 YP_002408256.1 CDS lysP NC_011750.1 2361271 2362740 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92250419, 94252996, 1315732, 7551055; Product type t : transporter; lysine transporter complement(2361271..2362740) Escherichia coli IAI39 7150950 YP_002408257.1 CDS yeiE NC_011750.1 2362945 2363826 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12400704, 1315732; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(2362945..2363826) Escherichia coli IAI39 7151984 YP_002408258.1 CDS yeiH NC_011750.1 2363925 2364974 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2363925..2364974 Escherichia coli IAI39 7153770 YP_002408259.1 CDS nfo NC_011750.1 2365048 2365905 D Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2365048..2365905 Escherichia coli IAI39 7153771 YP_002408260.1 CDS yeiI NC_011750.1 2365908 2366996 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2365908..2366996 Escherichia coli IAI39 7152215 YP_002408261.1 CDS yeiJ NC_011750.1 2367052 2368302 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sodium/proton nucleoside transporter complement(2367052..2368302) Escherichia coli IAI39 7153772 YP_002408262.1 CDS rihB NC_011750.1 2368402 2369343 R Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 complement(2368402..2369343) Escherichia coli IAI39 7153773 YP_002408263.1 CDS yeiL NC_011750.1 2369512 2370171 D activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 2369512..2370171 Escherichia coli IAI39 7152632 YP_002408264.1 CDS yeiM NC_011750.1 2370239 2371489 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sodium/proton nucleoside transporter complement(2370239..2371489) Escherichia coli IAI39 7153774 YP_002408265.1 CDS yeiN NC_011750.1 2371583 2372521 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2371583..2372521) Escherichia coli IAI39 7153775 YP_002408266.1 CDS yeiC NC_011750.1 2372509 2373450 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(2372509..2373450) Escherichia coli IAI39 7153777 YP_002408267.1 CDS fruA NC_011750.1 2373874 2375565 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunits IIBC complement(2373874..2375565) Escherichia coli IAI39 7153769 YP_002408268.1 CDS fruK NC_011750.1 2375582 2376520 R converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase complement(2375582..2376520) Escherichia coli IAI39 7151419 YP_002408269.1 CDS fruB NC_011750.1 2376520 2377650 R phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein complement(2376520..2377650) Escherichia coli IAI39 7151421 YP_002408270.1 CDS setB NC_011750.1 2378018 2379199 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438463, 10209755; Product type t : transporter; lactose/glucose efflux system 2378018..2379199 Escherichia coli IAI39 7151420 YP_002408271.1 CDS yeiW NC_011750.1 2379196 2379450 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2379196..2379450) Escherichia coli IAI39 7152834 YP_002408272.1 CDS yeiP NC_011750.1 2379605 2380177 D Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 2379605..2380177 Escherichia coli IAI39 7153785 YP_002408273.1 CDS yeiQ NC_011750.1 2380400 2381866 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar dehydrogenase, NAD-dependent 2380400..2381866 Escherichia coli IAI39 7153779 YP_002408274.1 CDS yeiR NC_011750.1 2381984 2382970 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 2381984..2382970 Escherichia coli IAI39 7153780 YP_002408275.1 CDS yeiU NC_011750.1 2383009 2383722 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15778224; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase 2383009..2383722 Escherichia coli IAI39 7153781 YP_002408276.1 CDS spr NC_011750.1 2384134 2384700 D by similarity, Spr seems to have peptidase activity; involved in thermoresistance; putative outer membrane lipoprotein 2384134..2384700 Escherichia coli IAI39 7153784 YP_002408277.1 CDS rtn NC_011750.1 2384881 2386437 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2384881..2386437 Escherichia coli IAI39 7152889 YP_002408278.1 CDS yejA NC_011750.1 2386519 2388333 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide ABC transporter subunit periplasmic-binding protein transporter 2386519..2388333 Escherichia coli IAI39 7152761 YP_002408279.1 CDS yejB NC_011750.1 2388334 2389428 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide ABC transporter permease 2388334..2389428 Escherichia coli IAI39 7153786 YP_002408280.1 CDS yejE NC_011750.1 2389428 2390453 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide ABC transporter permease 2389428..2390453 Escherichia coli IAI39 7153787 YP_002408281.1 CDS yejF NC_011750.1 2390455 2392044 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative oligopeptide ABC transporter subunits ATP-binding protein 2390455..2392044 Escherichia coli IAI39 7153788 YP_002408282.1 CDS yejG NC_011750.1 2392048 2392392 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2392048..2392392) Escherichia coli IAI39 7153789 YP_002408283.1 CDS bcr NC_011750.1 2392725 2393915 R Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system complement(2392725..2393915) Escherichia coli IAI39 7153790 YP_002408284.1 CDS rsuA NC_011750.1 2393943 2394638 R catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A complement(2393943..2394638) Escherichia coli IAI39 7150842 YP_002408285.1 CDS yejH NC_011750.1 2394788 2396548 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleic acid ATP-dependent helicase 2394788..2396548 Escherichia coli IAI39 7152751 YP_002408286.1 CDS rplY NC_011750.1 2396673 2396957 D the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 2396673..2396957 Escherichia coli IAI39 7153791 YP_002408287.1 CDS yejK NC_011750.1 2397096 2398103 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99296598, 10368163; Product type f : factor; nucleoid-associated protein NdpA complement(2397096..2398103) Escherichia coli IAI39 7152693 YP_002408288.1 CDS yejL NC_011750.1 2398285 2398512 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2398285..2398512 Escherichia coli IAI39 7153792 YP_002408289.1 CDS yejM NC_011750.1 2398532 2400292 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase, inner membrane-associated 2398532..2400292 Escherichia coli IAI39 7153793 YP_002408290.1 CDS yejO NC_011750.1 2400544 2403054 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15659678; Product type pt : putative transporter; putative autotransporter outer membrane protein; type V secretion complement(2400544..2403054) Escherichia coli IAI39 7150559 YP_002408291.1 CDS narP NC_011750.1 2403455 2404102 D nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 2403455..2404102 Escherichia coli IAI39 7153795 YP_002408292.1 CDS ccmH NC_011750.1 2404137 2405189 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 11756453, 12196152, 87260957, 91194558, 95362656, 9914305, 7635817; Product type pe : putative enzyme; heme lyase CcmH complement(2404137..2405189) Escherichia coli IAI39 7152194 YP_002408293.1 CDS ccmG NC_011750.1 2405186 2405743 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 9716493, 9770295, 11256948, 11350062, 11843181, 7635817, 9537397; Product type e : enzyme; periplasmic thioredoxin of cytochrome c-type biogenesis complement(2405186..2405743) Escherichia coli IAI39 7150918 YP_002408294.1 CDS ccmF NC_011750.1 2405740 2407683 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 11756453, 12196152, 87260957, 8842153, 91194558, 95362656, 9716493, 7635817; Product type e : enzyme; heme lyase CcmF complement(2405740..2407683) Escherichia coli IAI39 7150917 YP_002408295.1 CDS ccmE NC_011750.1 2407680 2408159 R CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE complement(2407680..2408159) Escherichia coli IAI39 7150916 YP_002408296.1 CDS ccmD NC_011750.1 2408156 2408365 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 95362656, 9716493, 7635817; Product type f : factor; cytochrome c biogenesis protein complement(2408156..2408365) Escherichia coli IAI39 7150915 YP_002408297.1 CDS ccmC NC_011750.1 2408362 2409099 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 14532274, 21413853, 95362656, 7635817; Product type t : transporter; heme ABC transporter membrane protein complement(2408362..2409099) Escherichia coli IAI39 7150914 YP_002408298.1 CDS ccmB NC_011750.1 2409141 2409803 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 95362656, 9716493, 7635817; Product type t : transporter; heme ABC transporter membrane protein complement(2409141..2409803) Escherichia coli IAI39 7150913 YP_002408299.1 CDS ccmA NC_011750.1 2409800 2410423 R ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA complement(2409800..2410423) Escherichia coli IAI39 7150912 YP_002408300.1 CDS napC NC_011750.1 2410436 2411038 R with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC complement(2410436..2411038) Escherichia coli IAI39 7150911 YP_002408301.1 CDS napB NC_011750.1 2411048 2411497 R small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit complement(2411048..2411497) Escherichia coli IAI39 7152184 YP_002408302.1 CDS napH NC_011750.1 2411494 2412357 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component complement(2411494..2412357) Escherichia coli IAI39 7152183 YP_002408303.1 CDS napG NC_011750.1 2412344 2413039 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component complement(2412344..2413039) Escherichia coli IAI39 7152187 YP_002408304.1 CDS napA NC_011750.1 2413046 2415532 R periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit complement(2413046..2415532) Escherichia coli IAI39 7152186 YP_002408305.1 CDS napD NC_011750.1 2415529 2415792 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96228696, 99395037; Product type f : factor; assembly protein for periplasmic nitrate reductase complement(2415529..2415792) Escherichia coli IAI39 7152182 YP_002408306.1 CDS eco NC_011750.1 2416684 2417172 D serine protease inhibitor, inhibits trypsin and other proteases; ecotin 2416684..2417172 Escherichia coli IAI39 7152185 YP_002408307.1 CDS mqo NC_011750.1 2417322 2418968 R malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase complement(2417322..2418968) Escherichia coli IAI39 7151199 YP_002408308.1 CDS yojI NC_011750.1 2419186 2420829 R efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane component/ATP-binding protein complement(2419186..2420829) Escherichia coli IAI39 7152117 YP_002408309.1 CDS alkB NC_011750.1 2420905 2421555 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12226668, 12517444, 12862460, 14527653, 87057220, 88151899, 92017669, 3536913, 3887409, 7928996; Product type e : enzyme; N1-methyladenine or N3-methylcytosine DNA lesion oxidative demethylase complement(2420905..2421555) Escherichia coli IAI39 7154462 YP_002408310.1 CDS ada NC_011750.1 2421555 2422619 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91073391, 93272965, 94252990; Product type r : regulator; fused DNA-binding transcriptional dual regulator ; O6-methylguanine-DNA methyltransferase complement(2421555..2422619) Escherichia coli IAI39 7150714 YP_002408311.1 CDS yojL NC_011750.1 2422693 2423748 R catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE complement(2422693..2423748) Escherichia coli IAI39 7150682 YP_002408312.1 CDS ompC NC_011750.1 2423860 2424954 R allows for ions and hydrophilic solutes to cross the outer membrane; outer membrane porin protein C complement(2423860..2424954) Escherichia coli IAI39 7154463 YP_002408313.1 CDS ECIAI39_2353 NC_011750.1 2425346 2425510 R hypothetical protein complement(2425346..2425510) Escherichia coli IAI39 7152082 YP_002408314.1 CDS rcsD NC_011750.1 2425693 2428365 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11758943, 12864862, 21206231, 2404948, 7984428; Product type r : regulator; phosphotransfer intermediate protein in two-component regulatory system with RcsBC 2425693..2428365 Escherichia coli IAI39 7149963 YP_002408315.1 CDS rcsB NC_011750.1 2428382 2429032 D two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 2428382..2429032 Escherichia coli IAI39 7152580 YP_002408316.1 CDS rcsC NC_011750.1 2429118 2431919 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11758943, 12864862, 14651646, 20032358, 21450811, 88227838, 90130299, 92048476, 9209051, 2404948, 8366025; Product type r : regulator; hybrid sensory kinase in two-component regulatory system with RcsB and YojN complement(2429118..2431919) Escherichia coli IAI39 7152578 YP_002408317.1 CDS atoS NC_011750.1 2432134 2433960 D with AtoC is a member of a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; sensory histidine kinase AtoS 2432134..2433960 Escherichia coli IAI39 7152579 YP_002408318.1 CDS atoC NC_011750.1 2433957 2435342 D with AtoS is a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism; acetoacetate metabolism regulatory protein AtoC 2433957..2435342 Escherichia coli IAI39 7150820 YP_002408319.1 CDS atoD NC_011750.1 2435538 2436200 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73032600, 87083402; Product type c : carrier; acetyl-CoA:acetoacetyl-CoA transferase subunit alpha 2435538..2436200 Escherichia coli IAI39 7150817 YP_002408320.1 CDS atoA NC_011750.1 2436200 2436850 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73032600, 87083402; Product type c : carrier; acetyl-CoA:acetoacetyl-CoA transferase subunit beta 2436200..2436850 Escherichia coli IAI39 7150818 YP_002408321.1 CDS atoE NC_011750.1 2436847 2438169 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73032600, 87083402; Product type t : transporter; short chain fatty acid transporter 2436847..2438169 Escherichia coli IAI39 7150815 YP_002408322.1 CDS atoB NC_011750.1 2438200 2439384 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73032600, 87083402; Product type c : carrier; acetyl-CoA acetyltransferase 2438200..2439384 Escherichia coli IAI39 7150819 YP_002408323.1 CDS yfaP NC_011750.1 2439458 2440234 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2439458..2440234) Escherichia coli IAI39 7150816 YP_002408324.1 CDS yfaQ NC_011750.1 2440239 2441888 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2440239..2441888) Escherichia coli IAI39 7153801 YP_002408325.1 CDS yfaT NC_011750.1 2446427 2447050 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2446427..2447050) Escherichia coli IAI39 7153804 YP_002408326.1 CDS yfaA NC_011750.1 2447047 2448735 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2447047..2448735) Escherichia coli IAI39 7153805 YP_002408327.1 CDS gyrA NC_011750.1 2448884 2451511 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A complement(2448884..2451511) Escherichia coli IAI39 7153796 YP_002408328.1 CDS ECIAI39_2370 NC_011750.1 2451862 2453076 R Mandelate racemase/muconate lactonizing enzyme family protein complement(2451862..2453076) Escherichia coli IAI39 7151605 YP_002408329.1 CDS ECIAI39_2371 NC_011750.1 2453077 2454405 R transporter, major facilitator family complement(2453077..2454405) Escherichia coli IAI39 7149964 YP_002408330.1 CDS ECIAI39_2372 NC_011750.1 2454643 2455341 D transcriptional regulator, GntR family 2454643..2455341 Escherichia coli IAI39 7149965 YP_002408331.1 CDS ubiG NC_011750.1 2455419 2456141 D Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2455419..2456141 Escherichia coli IAI39 7149966 YP_002408332.1 CDS yfaL NC_011750.1 2456280 2460044 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659678; Product type f : factor; adhesin complement(2456280..2460044) Escherichia coli IAI39 7153074 YP_002408333.1 CDS ECIAI39_2375 NC_011750.1 2460516 2460659 D hypothetical protein 2460516..2460659 Escherichia coli IAI39 7153799 YP_002408334.1 CDS nrdA NC_011750.1 2460740 2463025 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2460740..2463025 Escherichia coli IAI39 7149967 YP_002408335.1 CDS nrdB NC_011750.1 2463171 2464301 D B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 2463171..2464301 Escherichia coli IAI39 7152244 YP_002408336.1 CDS yfaE NC_011750.1 2464301 2464555 D plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin YfaE 2464301..2464555 Escherichia coli IAI39 7152245 YP_002408337.1 CDS inaA NC_011750.1 2464609 2465259 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 92165728, 1537798, 6087316; hypothetical protein complement(2464609..2465259) Escherichia coli IAI39 7153798 YP_002408338.1 CDS ECIAI39_2380 NC_011750.1 2465340 2466530 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11206551, 11258796; Product type pt : putative transporter; putative antibiotic efflux protein complement(2465340..2466530) Escherichia coli IAI39 7151776 YP_002408339.1 CDS ECIAI39_2381 NC_011750.1 2466682 2467581 D Evidence 4 : Homologs of previously reported genes of unknown function; putative transcriptional regulator 2466682..2467581 Escherichia coli IAI39 7149968 YP_002408340.1 CDS glpQ NC_011750.1 2467601 2468677 R hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase complement(2467601..2468677) Escherichia coli IAI39 7149969 YP_002408341.1 CDS glpT NC_011750.1 2468682 2470040 R catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter complement(2468682..2470040) Escherichia coli IAI39 7151544 YP_002408342.1 CDS glpA NC_011750.1 2470313 2471941 D anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 2470313..2471941 Escherichia coli IAI39 7151546 YP_002408343.1 CDS glpB NC_011750.1 2471931 2473190 D sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 2471931..2473190 Escherichia coli IAI39 7151536 YP_002408344.1 CDS glpC NC_011750.1 2473187 2474377 D anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 2473187..2474377 Escherichia coli IAI39 7151537 YP_002408345.1 CDS yfaD NC_011750.1 2474570 2475505 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2474570..2475505 Escherichia coli IAI39 7151538 YP_002408346.1 CDS ypaA NC_011750.1 2475518 2475703 D Evidence 7 : Gene remnant; putative transposase (fragment) 2475518..2475703 Escherichia coli IAI39 7153797 YP_002408347.1 CDS yfaU NC_011750.1 2475744 2476547 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12454498, 16511168, 8550403; Product type pe : putative enzyme; putative aldolase complement(2475744..2476547) Escherichia coli IAI39 7154464 YP_002408348.1 CDS yfaV NC_011750.1 2476565 2477854 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative carboxylate transporter; phthalate permease family complement(2476565..2477854) Escherichia coli IAI39 7153806 YP_002408349.1 CDS ECIAI39_2392 NC_011750.1 2478696 2479022 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 2478696..2479022 Escherichia coli IAI39 7153808 YP_002408350.1 CDS ECIAI39_2393 NC_011750.1 2479019 2479909 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 2479019..2479909 Escherichia coli IAI39 7149970 YP_002408351.1 CDS yfaX NC_011750.1 2480444 2481226 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(2480444..2481226) Escherichia coli IAI39 7153809 YP_002408352.1 CDS yfaY NC_011750.1 2481446 2482648 R Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A complement(2481446..2482648) Escherichia coli IAI39 7153810 YP_002408353.1 CDS yfaZ NC_011750.1 2482748 2483290 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative outer membrane porin protein complement(2482748..2483290) Escherichia coli IAI39 7153811 YP_002408354.1 CDS yfaO NC_011750.1 2483568 2483993 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16430214; Product type pe : putative enzyme; putative NUDIX hydrolase 2483568..2483993 Escherichia coli IAI39 7153812 YP_002408355.1 CDS ais NC_011750.1 2484032 2484634 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2484032..2484634) Escherichia coli IAI39 7153800 YP_002408356.1 CDS yfbE NC_011750.1 2484924 2486081 D catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 2484924..2486081 Escherichia coli IAI39 7150709 YP_002408357.1 CDS yfbF NC_011750.1 2486085 2487053 D catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 2486085..2487053 Escherichia coli IAI39 7153814 YP_002408358.1 CDS yfbG NC_011750.1 2487053 2489035 D Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 2487053..2489035 Escherichia coli IAI39 7153815 YP_002408359.1 CDS yfbH NC_011750.1 2489032 2489922 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2489032..2489922 Escherichia coli IAI39 7153816 YP_002408360.1 CDS arnT NC_011750.1 2489922 2491574 D catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 2489922..2491574 Escherichia coli IAI39 7153817 YP_002408361.1 CDS yfbW NC_011750.1 2491571 2491906 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2491571..2491906 Escherichia coli IAI39 7150774 YP_002408362.1 CDS yfbJ NC_011750.1 2491906 2492292 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2491906..2492292 Escherichia coli IAI39 7153828 YP_002408363.1 CDS pmrD NC_011750.1 2492286 2492552 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96015440, 15569938; Product type pt : putative transporter; polymyxin resistance protein B complement(2492286..2492552) Escherichia coli IAI39 7153818 YP_002408364.1 CDS menE NC_011750.1 2492662 2494017 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96186953, 8626063; Product type e : enzyme; O-succinylbenzoic acid--CoA ligase complement(2492662..2494017) Escherichia coli IAI39 7152432 YP_002408365.1 CDS menC NC_011750.1 2494014 2494976 R catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase complement(2494014..2494976) Escherichia coli IAI39 7152047 YP_002408366.1 CDS menB NC_011750.1 2494976 2495833 R catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase complement(2494976..2495833) Escherichia coli IAI39 7152045 YP_002408367.1 CDS yfbB NC_011750.1 2495848 2496606 R catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase YfbB complement(2495848..2496606) Escherichia coli IAI39 7152044 YP_002408368.1 CDS menD NC_011750.1 2496603 2498273 R SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase complement(2496603..2498273) Escherichia coli IAI39 7153813 YP_002408369.1 CDS menF NC_011750.1 2498362 2499657 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150206, 96140724, 2666397, 7984428, 8549818, 8764478; Product type e : enzyme; isochorismate synthase 2 complement(2498362..2499657) Escherichia coli IAI39 7152046 YP_002408370.1 CDS elaB NC_011750.1 2499736 2500041 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2499736..2500041) Escherichia coli IAI39 7152048 YP_002408371.1 CDS elaA NC_011750.1 2500089 2500556 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(2500089..2500556) Escherichia coli IAI39 7151209 YP_002408372.1 CDS elaC NC_011750.1 2500621 2501538 D member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2500621..2501538 Escherichia coli IAI39 7151208 YP_002408373.1 CDS elaD NC_011750.1 2501729 2502937 D ElaD; specific cysteine protease which targets ubiquitin and ubiquitin-like proteins covalently bound to target proteins; SseL in Salmonella is required for macrophage killing and virulence, and it is secreted by the salmonella pathogenicity island 2 type III secretion system; deubiquitinase 2501729..2502937 Escherichia coli IAI39 7151210 YP_002408374.1 CDS yfbK NC_011750.1 2503008 2504774 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2503008..2504774) Escherichia coli IAI39 7151211 YP_002408375.1 CDS insB NC_011750.1 2504907 2505410 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' complement(2504907..2505410) Escherichia coli IAI39 7153819 YP_002408376.1 CDS insA NC_011750.1 2505329 2505604 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA complement(2505329..2505604) Escherichia coli IAI39 7151796 YP_002408377.1 CDS yfbL NC_011750.1 2505688 2506659 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated peptidase 2505688..2506659 Escherichia coli IAI39 7151785 YP_002408378.1 CDS yfbM NC_011750.1 2506762 2507265 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2506762..2507265 Escherichia coli IAI39 7153820 YP_002408379.1 CDS nuoN NC_011750.1 2507332 2508789 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N complement(2507332..2508789) Escherichia coli IAI39 7153821 YP_002408380.1 CDS nuoM NC_011750.1 2508796 2510325 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M complement(2508796..2510325) Escherichia coli IAI39 7152281 YP_002408381.1 CDS nuoL NC_011750.1 2510491 2512332 R Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L complement(2510491..2512332) Escherichia coli IAI39 7152280 YP_002408382.1 CDS nuoK NC_011750.1 2512329 2512631 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K complement(2512329..2512631) Escherichia coli IAI39 7152279 YP_002408383.1 CDS nuoJ NC_011750.1 2512628 2513182 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J complement(2512628..2513182) Escherichia coli IAI39 7152278 YP_002408384.1 CDS nuoI NC_011750.1 2513194 2513736 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I complement(2513194..2513736) Escherichia coli IAI39 7152277 YP_002408385.1 CDS nuoH NC_011750.1 2513751 2514728 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H complement(2513751..2514728) Escherichia coli IAI39 7152276 YP_002408386.1 CDS nuoG NC_011750.1 2514725 2517457 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G complement(2514725..2517457) Escherichia coli IAI39 7152275 YP_002408387.1 CDS nuoF NC_011750.1 2517504 2518841 R shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F complement(2517504..2518841) Escherichia coli IAI39 7152274 YP_002408388.1 CDS nuoE NC_011750.1 2518838 2519338 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E complement(2518838..2519338) Escherichia coli IAI39 7152273 YP_002408389.1 CDS nuoC NC_011750.1 2519341 2521143 R NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D complement(2519341..2521143) Escherichia coli IAI39 7152272 YP_002408390.1 CDS nuoB NC_011750.1 2521237 2521899 R The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B complement(2521237..2521899) Escherichia coli IAI39 7152271 YP_002408391.1 CDS nuoA NC_011750.1 2521915 2522358 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A complement(2521915..2522358) Escherichia coli IAI39 7152270 YP_002408392.1 CDS lrhA NC_011750.1 2522988 2523926 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123461, 9882671, 7565112; Product type r : regulator; DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes complement(2522988..2523926) Escherichia coli IAI39 7152269 YP_002408393.1 CDS yfbQ NC_011750.1 2524846 2526063 D broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 2524846..2526063 Escherichia coli IAI39 7151973 YP_002408394.1 CDS yfbR NC_011750.1 2526147 2526746 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15489502; Product type e : enzyme; hypothetical protein 2526147..2526746 Escherichia coli IAI39 7153822 YP_002408395.1 CDS yfbS NC_011750.1 2526805 2528637 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(2526805..2528637) Escherichia coli IAI39 7153823 YP_002408396.1 CDS yfbT NC_011750.1 2528724 2529374 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphatase complement(2528724..2529374) Escherichia coli IAI39 7153824 YP_002408397.1 CDS yfbU NC_011750.1 2529385 2529879 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2529385..2529879) Escherichia coli IAI39 7153825 YP_002408398.1 CDS yfbV NC_011750.1 2529962 2530417 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2529962..2530417) Escherichia coli IAI39 7153826 YP_002408399.1 CDS ackA NC_011750.1 2530755 2531957 D AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2530755..2531957 Escherichia coli IAI39 7153827 YP_002408400.1 CDS pta NC_011750.1 2532032 2534176 D catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 2532032..2534176 Escherichia coli IAI39 7150665 YP_002408401.1 CDS yfcC NC_011750.1 2534366 2535886 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pc : putative carrier; hypothetical protein 2534366..2535886 Escherichia coli IAI39 7152513 YP_002408402.1 CDS yfcD NC_011750.1 2535919 2536461 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16430214; Product type pe : putative enzyme; putative NUDIX hydrolase complement(2535919..2536461) Escherichia coli IAI39 7153830 YP_002408403.1 CDS yfcE NC_011750.1 2536519 2537073 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; phosphodiesterase complement(2536519..2537073) Escherichia coli IAI39 7153831 YP_002408404.1 CDS yfcF NC_011750.1 2537126 2537770 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(2537126..2537770) Escherichia coli IAI39 7153832 YP_002408405.1 CDS yfcG NC_011750.1 2537906 2538553 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; glutathione S-transferase 2537906..2538553 Escherichia coli IAI39 7153833 YP_002408406.1 CDS folX NC_011750.1 2538610 2538972 D catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 2538610..2538972 Escherichia coli IAI39 7153834 YP_002408407.1 CDS yfcH NC_011750.1 2538993 2539886 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : putative enzyme; hypothetical protein 2538993..2539886 Escherichia coli IAI39 7151405 YP_002408408.1 CDS ECIAI39_2452 NC_011750.1 2539947 2541386 R hypothetical protein complement(2539947..2541386) Escherichia coli IAI39 7153835 YP_002408409.1 CDS ECIAI39_2453 NC_011750.1 2541383 2542600 R cystathionine gamma-synthase complement(2541383..2542600) Escherichia coli IAI39 7149979 YP_002408410.1 CDS yfcI NC_011750.1 2542907 2543809 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase complement(2542907..2543809) Escherichia coli IAI39 7149980 YP_002408411.1 CDS hisP NC_011750.1 2544005 2544778 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 3313284, 91060556; Product type t : transporter; histidine/lysine/arginine/ornithine transporter subunit complement(2544005..2544778) Escherichia coli IAI39 7153836 YP_002408412.1 CDS hisM NC_011750.1 2544786 2545502 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 3313284; Product type t : transporter; histidine/lysine/arginine/ornithine ABC transporter membrane protein complement(2544786..2545502) Escherichia coli IAI39 7151657 YP_002408413.1 CDS hisQ NC_011750.1 2545499 2546185 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434; Product type t : transporter; histidine/lysine/arginine/ornithine ABC transporter membrane protein complement(2545499..2546185) Escherichia coli IAI39 7151656 YP_002408414.1 CDS hisJ NC_011750.1 2546275 2547057 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 6449635, 8161536, 9298646, 9600841, 9740056; Product type t : transporter; histidine/lysine/arginine/ornithine ABC transporter subunit periplasmic-binding protein complement(2546275..2547057) Escherichia coli IAI39 7151658 YP_002408415.1 CDS argT NC_011750.1 2547278 2548060 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4583243, 87308226, 3040734, 9298646; Product type t : transporter; lysine/arginine/ornithine ABC transporter subunit periplasmic-binding protein complement(2547278..2548060) Escherichia coli IAI39 7151654 YP_002408416.1 CDS ubiX NC_011750.1 2548326 2548895 R catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase complement(2548326..2548895) Escherichia coli IAI39 7150773 YP_002408417.1 CDS purF NC_011750.1 2548990 2550507 R Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase complement(2548990..2550507) Escherichia coli IAI39 7153076 YP_002408418.1 CDS cvpA NC_011750.1 2550544 2551032 R membrane protein required for colicin V production; colicin V production protein complement(2550544..2551032) Escherichia coli IAI39 7152528 YP_002408419.1 CDS dedD NC_011750.1 2551362 2552024 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3040734; hypothetical protein complement(2551362..2552024) Escherichia coli IAI39 7151036 YP_002408420.1 CDS folC NC_011750.1 2552014 2553282 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3040739, 91112811, 92041808, 1989505, 3040734; Product type e : enzyme; bifunctional folylpolyglutamate synthase/ dihydrofolate synthase complement(2552014..2553282) Escherichia coli IAI39 7151112 YP_002408421.1 CDS accD NC_011750.1 2553352 2554266 R catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta complement(2553352..2554266) Escherichia coli IAI39 7151399 YP_002408422.1 CDS dedA NC_011750.1 2554422 2555081 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3029016, 3040734, 7678242; Product type pm : putative membrane component; hypothetical protein complement(2554422..2555081) Escherichia coli IAI39 7150659 YP_002408423.1 CDS truA NC_011750.1 2555164 2555976 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(2555164..2555976) Escherichia coli IAI39 7151111 YP_002408424.1 CDS usg NC_011750.1 2555976 2556989 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 92380957, 92380982, 93123150, 2681152, 2991861, 3029016; Product type pe : putative enzyme; putative semialdehyde dehydrogenase complement(2555976..2556989) Escherichia coli IAI39 7153039 YP_002408425.1 CDS pdxB NC_011750.1 2557055 2558191 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90036695, 91035267, 2681152, 2991861, 3029016; Product type e : enzyme; erythronate-4-phosphate dehydrogenase complement(2557055..2558191) Escherichia coli IAI39 7153107 YP_002408426.1 CDS flk NC_011750.1 2558290 2559285 D in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 2558290..2559285 Escherichia coli IAI39 7152356 YP_002408427.1 CDS yfcJ NC_011750.1 2559282 2560460 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein complement(2559282..2560460) Escherichia coli IAI39 7151392 YP_002408428.1 CDS fabB NC_011750.1 2560725 2561945 R FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase I complement(2560725..2561945) Escherichia coli IAI39 7153837 YP_002408429.1 CDS mnmC NC_011750.1 2562104 2564110 D catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 2562104..2564110 Escherichia coli IAI39 7151264 YP_002408430.1 CDS yfcL NC_011750.1 2564166 2564444 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2564166..2564444) Escherichia coli IAI39 7153026 YP_002408431.1 CDS yfcM NC_011750.1 2564478 2565026 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2564478..2565026) Escherichia coli IAI39 7153838 YP_002408432.1 CDS yfcA NC_011750.1 2565026 2565835 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2565026..2565835) Escherichia coli IAI39 7153839 YP_002408433.1 CDS mepA NC_011750.1 2565835 2566659 R D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase complement(2565835..2566659) Escherichia coli IAI39 7153829 YP_002408434.1 CDS aroC NC_011750.1 2566662 2567747 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(2566662..2567747) Escherichia coli IAI39 7152049 YP_002408435.1 CDS prmB NC_011750.1 2567782 2568714 R involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase complement(2567782..2568714) Escherichia coli IAI39 7150777 YP_002408436.1 CDS yfcN NC_011750.1 2568880 2569431 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2568880..2569431 Escherichia coli IAI39 7152481 YP_002408437.1 CDS ECIAI39_2481 NC_011750.1 2569517 2570086 D SMC domain-containing protein (fragment) 2569517..2570086 Escherichia coli IAI39 7153840 YP_002408438.1 CDS ECIAI39_2482 NC_011750.1 2570201 2570731 D SMC domain-containing protein (fragment) 2570201..2570731 Escherichia coli IAI39 7149981 YP_002408439.1 CDS ECIAI39_2483 NC_011750.1 2570697 2571320 D hypothetical protein 2570697..2571320 Escherichia coli IAI39 7149982 YP_002408440.1 CDS yfcO NC_011750.1 2571369 2572229 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2571369..2572229) Escherichia coli IAI39 7149983 YP_002408441.1 CDS yfcP NC_011750.1 2572216 2572746 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative exported fimbrial-like adhesin protein complement(2572216..2572746) Escherichia coli IAI39 7153841 YP_002408442.1 CDS yfcQ NC_011750.1 2572743 2573222 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein complement(2572743..2573222) Escherichia coli IAI39 7153842 YP_002408443.1 CDS yfcR NC_011750.1 2573219 2573788 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein complement(2573219..2573788) Escherichia coli IAI39 7153843 YP_002408444.1 CDS yfcS NC_011750.1 2573739 2574491 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative periplasmic pilus exported chaperone complement(2573739..2574491) Escherichia coli IAI39 7153844 YP_002408445.1 CDS yfcU NC_011750.1 2574511 2577168 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative export usher protein complement(2574511..2577168) Escherichia coli IAI39 7153845 YP_002408446.1 CDS yfcV NC_011750.1 2577243 2577809 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial-like adhesin exported protein complement(2577243..2577809) Escherichia coli IAI39 7153846 YP_002408447.1 CDS sixA NC_011750.1 2578329 2578814 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10089421, 20200300, 9489669; Product type e : enzyme; phosphohistidine phosphatase complement(2578329..2578814) Escherichia coli IAI39 7153847 YP_002408448.1 CDS fadJ NC_011750.1 2579017 2581161 R multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha complement(2579017..2581161) Escherichia coli IAI39 7152857 YP_002408449.1 CDS fadI NC_011750.1 2581161 2582471 R FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase complement(2581161..2582471) Escherichia coli IAI39 7153848 YP_002408450.1 CDS yfcZ NC_011750.1 2582652 2582936 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2582652..2582936) Escherichia coli IAI39 7153849 YP_002408451.1 CDS fadL NC_011750.1 2583302 2584648 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15178802, 2840553, 3286621, 91100327, 1987139, 9119048; Product type t : transporter; long-chain fatty acid outer membrane transporter 2583302..2584648 Escherichia coli IAI39 7153850 YP_002408452.1 CDS yfdF NC_011750.1 2585015 2586262 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2585015..2586262 Escherichia coli IAI39 7151277 YP_002408453.1 CDS vacJ NC_011750.1 2586441 2587196 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8145644, 15352239; Product type lp : lipoprotein; putative lipoprotein complement(2586441..2587196) Escherichia coli IAI39 7153853 YP_002408454.1 CDS yfdC NC_011750.1 2587490 2588422 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2587490..2588422 Escherichia coli IAI39 7153125 YP_002408455.1 CDS intS NC_011750.1 2588734 2589891 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative prophage CPS-53 integrase; CPS-53 (KpLE1) prophage 2588734..2589891 Escherichia coli IAI39 7150560 YP_002408456.1 CDS ECIAI39_2502 NC_011750.1 2590426 2590752 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 2590426..2590752 Escherichia coli IAI39 7151835 YP_002408457.1 CDS ECIAI39_2503 NC_011750.1 2590749 2591639 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 2590749..2591639 Escherichia coli IAI39 7149984 YP_002408458.1 CDS ECIAI39_2504 NC_011750.1 2591679 2595179 R outer membrane autotransporter domain-containing protein (fragment) complement(2591679..2595179) Escherichia coli IAI39 7149985 YP_002408459.1 CDS ECIAI39_2505 NC_011750.1 2596142 2596771 R Type 1 fimbriae regulatory protein fimB complement(2596142..2596771) Escherichia coli IAI39 7149986 YP_002408460.1 CDS ECIAI39_2506 NC_011750.1 2597520 2598089 D Type 1 fimbriae regulatory protein fimB 2597520..2598089 Escherichia coli IAI39 7149987 YP_002408461.1 CDS dsdC NC_011750.1 2598484 2599437 R regulates the synthesis and expression of the dsdXA operon and dadA gene; DNA-binding transcriptional regulator DsdC complement(2598484..2599437) Escherichia coli IAI39 7149988 YP_002408462.1 CDS dsdX NC_011750.1 2599649 2600986 D member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; permease DsdX 2599649..2600986 Escherichia coli IAI39 7151178 YP_002408463.1 CDS dsdA NC_011750.1 2601004 2602335 D catalyzes the formation of pyruvate from serine; D-serine dehydratase 2601004..2602335 Escherichia coli IAI39 7151180 YP_002408464.1 CDS emrY NC_011750.1 2602440 2603978 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20378313; Product type pt : putative transporter; putative multidrug efflux system complement(2602440..2603978) Escherichia coli IAI39 7151176 YP_002408465.1 CDS emrK NC_011750.1 2603978 2605141 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20378313; Product type t : transporter; EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component complement(2603978..2605141) Escherichia coli IAI39 7151218 YP_002408466.1 CDS evgA NC_011750.1 2605557 2606171 D response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; DNA-binding transcriptional activator EvgA 2605557..2606171 Escherichia coli IAI39 7151217 YP_002408467.1 CDS evgS NC_011750.1 2606176 2609769 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14523115, 93173621, 9501520, 10923791, 1289796, 8125343, 9535079; Product type r : regulator; hybrid sensory histidine kinase in two-component regulatory system with EvgA 2606176..2609769 Escherichia coli IAI39 7151255 YP_002408468.1 CDS yfdE NC_011750.1 2609825 2610970 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(2609825..2610970) Escherichia coli IAI39 7151256 YP_002408469.1 CDS yfdV NC_011750.1 2611044 2611988 R member of the AEC family of auxin efflux transporters; unknown function; putative transporter YfdV complement(2611044..2611988) Escherichia coli IAI39 7153852 YP_002408470.1 CDS oxc NC_011750.1 2612057 2613751 R catalyzes the formation of formyl-CoA from oxalyl-CoA; putative oxalyl-CoA decarboxylase complement(2612057..2613751) Escherichia coli IAI39 7153857 YP_002408471.1 CDS frc NC_011750.1 2613805 2615055 R catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase complement(2613805..2615055) Escherichia coli IAI39 7152314 YP_002408472.1 CDS yfdX NC_011750.1 2615567 2616199 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11157960; hypothetical protein complement(2615567..2616199) Escherichia coli IAI39 7151407 YP_002408473.1 CDS ypdI NC_011750.1 2616495 2616770 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15183873; Product type lp : lipoprotein; putative lipoprotein 2616495..2616770 Escherichia coli IAI39 7153858 YP_002408474.1 CDS ECIAI39_2520 NC_011750.1 2616746 2616892 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2616746..2616892) Escherichia coli IAI39 7154474 YP_002408475.1 CDS yfdY NC_011750.1 2616847 2617089 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089; Product type pm : putative membrane component; hypothetical protein complement(2616847..2617089) Escherichia coli IAI39 7149989 YP_002408476.1 CDS ddg NC_011750.1 2617442 2618362 D Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 2617442..2618362 Escherichia coli IAI39 7153859 YP_002408477.1 CDS yfdZ NC_011750.1 2618854 2620092 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; aminotransferase complement(2618854..2620092) Escherichia coli IAI39 7153015 YP_002408478.1 CDS ypdA NC_011750.1 2620469 2622166 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15522865; Product type prc : putative receptor; putative sensory kinase in two-component system with YpdB 2620469..2622166 Escherichia coli IAI39 7153860 YP_002408479.1 CDS ypdB NC_011750.1 2622163 2622918 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15522865; Product type pr : putative regulator; putative response regulator in two-component system with YpdA 2622163..2622918 Escherichia coli IAI39 7154465 YP_002408480.1 CDS ypdC NC_011750.1 2622931 2623788 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding protein 2622931..2623788 Escherichia coli IAI39 7154466 YP_002408481.1 CDS ypdE NC_011750.1 2626234 2627271 R metalloprotein; exoaminopeptidase complement(2626234..2627271) Escherichia coli IAI39 7154469 YP_002408482.1 CDS ypdF NC_011750.1 2627271 2628356 R Xaa-Pro aminopeptidase; limited methionine aminopeptidase; aminopeptidase complement(2627271..2628356) Escherichia coli IAI39 7154470 YP_002408483.1 CDS ypdG NC_011750.1 2628371 2629618 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative enzyme IIC component of PTS complement(2628371..2629618) Escherichia coli IAI39 7154471 YP_002408484.1 CDS ypdH NC_011750.1 2629640 2629966 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative enzyme IIB component of PTS complement(2629640..2629966) Escherichia coli IAI39 7154472 YP_002408485.1 CDS glk NC_011750.1 2630185 2631150 R catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase complement(2630185..2631150) Escherichia coli IAI39 7154473 YP_002408486.1 CDS yfeO NC_011750.1 2631354 2632610 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein 2631354..2632610 Escherichia coli IAI39 7151518 YP_002408487.1 CDS ypeC NC_011750.1 2632725 2633051 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2632725..2633051 Escherichia coli IAI39 7153868 YP_002408488.1 CDS ECIAI39_2536 NC_011750.1 2633136 2633666 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 2633136..2633666 Escherichia coli IAI39 7154477 YP_002408489.1 CDS ECIAI39_2537 NC_011750.1 2633771 2634493 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 2633771..2634493 Escherichia coli IAI39 7149990 YP_002408490.1 CDS mntH NC_011750.1 2634629 2635867 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20177822, 20305051, 10712688, 10844693; Product type t : transporter; manganese transport protein MntH complement(2634629..2635867) Escherichia coli IAI39 7149991 YP_002408491.1 CDS nupC NC_011750.1 2636203 2637405 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 374403, 8022285, 7007808, 827549, 4563236, 1512211; Product type t : transporter; nucleoside (except guanosine) transporter 2636203..2637405 Escherichia coli IAI39 7152093 YP_002408492.1 CDS yfeA NC_011750.1 2637454 2639643 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative diguanylate cyclase complement(2637454..2639643) Escherichia coli IAI39 7152282 YP_002408493.1 CDS yfeC NC_011750.1 2640277 2640621 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative nucleic acid-binding transcriptional regulator 2640277..2640621 Escherichia coli IAI39 7150614 YP_002408494.1 CDS yfeD NC_011750.1 2640623 2641015 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative nucleic acid-binding transcriptional regulator 2640623..2641015 Escherichia coli IAI39 7153862 YP_002408495.1 CDS yncK NC_011750.1 2642320 2642556 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A (remnant), IS609 2642320..2642556 Escherichia coli IAI39 7153529 YP_002408496.1 CDS gltX NC_011750.1 2642812 2644227 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(2642812..2644227) Escherichia coli IAI39 7154407 YP_002408497.1 CDS xapR NC_011750.1 2645054 2645938 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7559336; Product type r : regulator; DNA-binding transcriptional activator XapR complement(2645054..2645938) Escherichia coli IAI39 7150566 YP_002408498.1 CDS xapB NC_011750.1 2646013 2647269 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96032385, 7559336; Product type t : transporter; xanthosine transporter complement(2646013..2647269) Escherichia coli IAI39 7153174 YP_002408499.1 CDS ECIAI39_2549 NC_011750.1 2647154 2647354 R hypothetical protein complement(2647154..2647354) Escherichia coli IAI39 7153173 YP_002408500.1 CDS xapA NC_011750.1 2647327 2648160 R catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase complement(2647327..2648160) Escherichia coli IAI39 7149992 YP_002408501.1 CDS ECIAI39_2551 NC_011750.1 2648389 2649318 R hypothetical protein complement(2648389..2649318) Escherichia coli IAI39 7153172 YP_002408502.1 CDS ECIAI39_2552 NC_011750.1 2649373 2650686 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative nucleoside transporter complement(2649373..2650686) Escherichia coli IAI39 7149993 YP_002408503.1 CDS yfeN NC_011750.1 2650871 2651650 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 2650871..2651650 Escherichia coli IAI39 7149994 YP_002408504.1 CDS yfeH NC_011750.1 2651889 2652887 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative sodium/bile acid symporter family (mazG-like) 2651889..2652887 Escherichia coli IAI39 7153867 YP_002408505.1 CDS ypeB NC_011750.1 2652884 2653102 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2652884..2653102) Escherichia coli IAI39 7153865 YP_002408506.1 CDS ligA NC_011750.1 2653104 2655119 R this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA complement(2653104..2655119) Escherichia coli IAI39 7154476 YP_002408507.1 CDS zipA NC_011750.1 2655190 2656176 R interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA complement(2655190..2656176) Escherichia coli IAI39 7151935 YP_002408508.1 CDS cysZ NC_011750.1 2656418 2657179 D putative role in sulfur assimilation; putative sulfate transport protein CysZ 2656418..2657179 Escherichia coli IAI39 7154588 YP_002408509.1 CDS ECIAI39_2559 NC_011750.1 2657207 2657371 D hypothetical protein 2657207..2657371 Escherichia coli IAI39 7151072 YP_002408510.1 CDS cysK NC_011750.1 2657364 2658335 D CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 2657364..2658335 Escherichia coli IAI39 7149995 YP_002408511.1 CDS ptsH NC_011750.1 2658719 2658976 D Evidence 1b : Function experimentally demonstrated in the studied species; Product type t : transporter; PTS system phosphohistidinoprotein-hexose phosphotransferase subunit Hpr 2658719..2658976 Escherichia coli IAI39 7151064 YP_002408512.1 CDS ptsI NC_011750.1 2659021 2660748 D Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 2659021..2660748 Escherichia coli IAI39 7152519 YP_002408513.1 CDS crr NC_011750.1 2660789 2661298 D functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter subunit 2660789..2661298 Escherichia coli IAI39 7152520 YP_002408514.1 CDS pdxK NC_011750.1 2661341 2662192 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase complement(2661341..2662192) Escherichia coli IAI39 7151001 YP_002408515.1 CDS yfeK NC_011750.1 2662297 2662665 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2662297..2662665 Escherichia coli IAI39 7152359 YP_002408516.1 CDS cysM NC_011750.1 2662668 2663579 R catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B complement(2662668..2663579) Escherichia coli IAI39 7153866 YP_002408517.1 CDS cysA NC_011750.1 2663713 2664810 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202710, 90264334, 2188958, 7665461; Product type t : transporter; sulfate/thiosulfate transporter subunit complement(2663713..2664810) Escherichia coli IAI39 7151065 YP_002408518.1 CDS cysW NC_011750.1 2664800 2665675 R Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate transporter permease subunit complement(2664800..2665675) Escherichia coli IAI39 7151055 YP_002408519.1 CDS cysU NC_011750.1 2665675 2666508 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264334, 2188958; Product type t : transporter; sulfate/thiosulfate transporter subunit complement(2665675..2666508) Escherichia coli IAI39 7151071 YP_002408520.1 CDS cysP NC_011750.1 2666508 2667524 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264335, 2188959, 9298646; Product type t : transporter; thiosulfate transporter subunit complement(2666508..2667524) Escherichia coli IAI39 7151070 YP_002408521.1 CDS ucpA NC_011750.1 2667682 2668473 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 97385354, 2188959, 7984428, 9241368; Product type pe : putative enzyme; short chain dehydrogenase complement(2667682..2668473) Escherichia coli IAI39 7151067 YP_002408522.1 CDS yfeT NC_011750.1 2668602 2669459 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(2668602..2669459) Escherichia coli IAI39 7153077 YP_002408523.1 CDS murQ NC_011750.1 2669623 2670519 D catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid-6-phosphate etherase 2669623..2670519 Escherichia coli IAI39 7153869 YP_002408524.1 CDS murP NC_011750.1 2670523 2671947 D belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; PTS system N-acetylmuramic acid transporter subunits EIIBC 2670523..2671947 Escherichia coli IAI39 7153870 YP_002408525.1 CDS murQ NC_011750.1 2671952 2673250 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15983044, 15060041; Product type e : enzyme; hypothetical protein 2671952..2673250 Escherichia coli IAI39 7152153 YP_002408526.1 CDS yfeX NC_011750.1 2673308 2674207 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2673308..2674207) Escherichia coli IAI39 7152154 YP_002408527.1 CDS yfeY NC_011750.1 2674303 2674878 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12900013, 7764507; hypothetical protein complement(2674303..2674878) Escherichia coli IAI39 7153871 YP_002408528.1 CDS yfeZ NC_011750.1 2674939 2675388 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2674939..2675388) Escherichia coli IAI39 7153872 YP_002408529.1 CDS ypeA NC_011750.1 2675375 2675800 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase complement(2675375..2675800) Escherichia coli IAI39 7153873 YP_002408530.1 CDS amiA NC_011750.1 2676014 2676883 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21348478, 6137479, 87242501, 1903834, 8300522; Product type e : enzyme; N-acetylmuramoyl-l-alanine amidase I 2676014..2676883 Escherichia coli IAI39 7154475 YP_002408531.1 CDS hemF NC_011750.1 2676887 2677786 D catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 2676887..2677786 Escherichia coli IAI39 7150725 YP_002408532.1 CDS yfeG NC_011750.1 2677792 2678844 R activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR complement(2677792..2678844) Escherichia coli IAI39 7151629 YP_002408533.1 CDS yffI NC_011750.1 2678890 2679390 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10464203; Product type ps : putative structure; putative ethanolaminosome structural protein with putative role in ethanolamine utilization complement(2678890..2679390) Escherichia coli IAI39 7153864 YP_002408534.1 CDS eutL NC_011750.1 2679403 2680062 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-related structural protein with putative role in ethanolamine utilization complement(2679403..2680062) Escherichia coli IAI39 7153876 YP_002408535.1 CDS eutC NC_011750.1 2680072 2680959 R catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit complement(2680072..2680959) Escherichia coli IAI39 7151251 YP_002408536.1 CDS eutA NC_011750.1 2682353 2683756 R ethanolamine utilization protein EutA; reactivating factor for ethanolamine ammonia lyase complement(2682353..2683756) Escherichia coli IAI39 7151244 YP_002408537.1 CDS eutH NC_011750.1 2683753 2684979 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7868611, 10464203; Product type pt : putative transporter; putative ethanolamine transporter complement(2683753..2684979) Escherichia coli IAI39 7151242 YP_002408538.1 CDS eutG NC_011750.1 2685096 2686283 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative alcohol dehydrogenase in ethanolamine utilization; ethanolaminosome complement(2685096..2686283) Escherichia coli IAI39 7151248 YP_002408539.1 CDS eutJ NC_011750.1 2686273 2687109 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pf : putative factor; putative chaperonin, ethanolamine utilization protein complement(2686273..2687109) Escherichia coli IAI39 7151247 YP_002408540.1 CDS eutE NC_011750.1 2687120 2688523 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative aldehyde dehydrogenase, ethanolamine utilization protein complement(2687120..2688523) Escherichia coli IAI39 7151250 YP_002408541.1 CDS cchB NC_011750.1 2688535 2688822 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein complement(2688535..2688822) Escherichia coli IAI39 7151246 YP_002408542.1 CDS cchA NC_011750.1 2688928 2689221 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein complement(2688928..2689221) Escherichia coli IAI39 7150910 YP_002408543.1 CDS eutD NC_011750.1 2689260 2690276 R in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase complement(2689260..2690276) Escherichia coli IAI39 7150909 YP_002408544.1 CDS eutT NC_011750.1 2690273 2691076 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative cobalamin adenosyltransferase in ethanolamine utilization complement(2690273..2691076) Escherichia coli IAI39 7151249 YP_002408545.1 CDS eutQ NC_011750.1 2691073 2691774 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10464203; hypothetical protein complement(2691073..2691774) Escherichia coli IAI39 7151254 YP_002408546.1 CDS eutP NC_011750.1 2691749 2692228 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : putative enzyme; putative nucleoside triphosphate hydrolase domain-containing protein complement(2691749..2692228) Escherichia coli IAI39 7151253 YP_002408547.1 CDS ypfE NC_011750.1 2692241 2692576 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : putative structure; putative carboxysome-like ethanolaminosome structural protein with putative role in ethanol utilization complement(2692241..2692576) Escherichia coli IAI39 7151252 YP_002408548.1 CDS maeB NC_011750.1 2692869 2695148 R NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme complement(2692869..2695148) Escherichia coli IAI39 7154478 YP_002408549.1 CDS talA NC_011750.1 2695437 2696387 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90230300; Product type e : enzyme; transaldolase A 2695437..2696387 Escherichia coli IAI39 7151993 YP_002408550.1 CDS tktB NC_011750.1 2696407 2698410 D catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2696407..2698410 Escherichia coli IAI39 7152938 YP_002408551.1 CDS ypfG NC_011750.1 2698487 2699530 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2698487..2699530) Escherichia coli IAI39 7152990 YP_002408552.1 CDS yffH NC_011750.1 2699656 2700231 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NUDIX hydrolase complement(2699656..2700231) Escherichia coli IAI39 7154479 YP_002408553.1 CDS aegA NC_011750.1 2700299 2702278 R unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); putative oxidoreductase complement(2700299..2702278) Escherichia coli IAI39 7153875 YP_002408554.1 CDS narQ NC_011750.1 2702484 2704184 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92374842, 1508040, 1528845; Product type r : regulator; nitrate/nitrite sensor protein NarQ 2702484..2704184 Escherichia coli IAI39 7150694 YP_002408555.1 CDS acrD NC_011750.1 2704348 2707461 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12426336, 20158894, 21450803, 79216220, 10692383, 1644752; Product type t : transporter; aminoglycoside/multidrug efflux system 2704348..2707461 Escherichia coli IAI39 7152195 YP_002408556.1 CDS ECIAI39_2608 NC_011750.1 2707548 2707727 D hypothetical protein 2707548..2707727 Escherichia coli IAI39 7150675 YP_002408557.1 CDS yffB NC_011750.1 2708000 2708356 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2708000..2708356 Escherichia coli IAI39 7149996 YP_002408558.1 CDS dapE NC_011750.1 2708360 2709487 D dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2708360..2709487 Escherichia coli IAI39 7153874 YP_002408559.1 CDS ypfN NC_011750.1 2709515 2709715 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2709515..2709715 Escherichia coli IAI39 7151087 YP_002408560.1 CDS ypfH NC_011750.1 2709796 2710494 R Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YpfH complement(2709796..2710494) Escherichia coli IAI39 7154483 YP_002408561.1 CDS ypfI NC_011750.1 2710568 2712583 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase complement(2710568..2712583) Escherichia coli IAI39 7154480 YP_002408562.1 CDS ypfJ NC_011750.1 2712598 2713461 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2712598..2713461) Escherichia coli IAI39 7154481 YP_002408563.1 CDS purC NC_011750.1 2713629 2714342 R catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase complement(2713629..2714342) Escherichia coli IAI39 7154482 YP_002408564.1 CDS nlpB NC_011750.1 2714555 2715589 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358331, 1885529, 2120198; Product type lp : lipoprotein; lipoprotein complement(2714555..2715589) Escherichia coli IAI39 7152525 YP_002408565.1 CDS dapA NC_011750.1 2715606 2716484 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(2715606..2716484) Escherichia coli IAI39 7152234 YP_002408566.1 CDS gcvR NC_011750.1 2716630 2717202 D negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 2716630..2717202 Escherichia coli IAI39 7151084 YP_002408567.1 CDS bcp NC_011750.1 2717202 2717672 D bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 2717202..2717672 Escherichia coli IAI39 7151499 YP_002408568.1 CDS hyfA NC_011750.1 2717925 2718542 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241, 2016588; Product type c : carrier; hydrogenase 4, 4Fe-4S subunit 2717925..2718542 Escherichia coli IAI39 7150841 YP_002408569.1 CDS hyfB NC_011750.1 2718542 2720560 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4 subunit B 2718542..2720560 Escherichia coli IAI39 7151721 YP_002408570.1 CDS hyfC NC_011750.1 2720571 2721518 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4, membrane subunit 2720571..2721518 Escherichia coli IAI39 7151722 YP_002408571.1 CDS hyfD NC_011750.1 2721535 2722974 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4 subunit D 2721535..2722974 Escherichia coli IAI39 7151723 YP_002408572.1 CDS hyfE NC_011750.1 2722986 2723636 D interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 2722986..2723636 Escherichia coli IAI39 7151724 YP_002408573.1 CDS hyfF NC_011750.1 2723641 2725221 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4 subunit F 2723641..2725221 Escherichia coli IAI39 7151725 YP_002408574.1 CDS hyfG NC_011750.1 2725259 2726926 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type c : carrier; hydrogenase 4 subunit 2725259..2726926 Escherichia coli IAI39 7151726 YP_002408575.1 CDS hyfH NC_011750.1 2726936 2727481 D probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far; hydrogenase 4 subunit H 2726936..2727481 Escherichia coli IAI39 7151727 YP_002408576.1 CDS hyfI NC_011750.1 2727478 2728236 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type c : carrier; hydrogenase 4, Fe-S subunit 2727478..2728236 Escherichia coli IAI39 7151728 YP_002408577.1 CDS hyfJ NC_011750.1 2728229 2728642 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9387241; Product type pf : putative factor; putative processing element hydrogenase 4 2728229..2728642 Escherichia coli IAI39 7151729 YP_002408578.1 CDS focB NC_011750.1 2730706 2731554 D inner membrane protein presumed to act as a formate transporter; member of the hyf operon; putative formate transporter 2730706..2731554 Escherichia coli IAI39 7151732 YP_002408579.1 CDS perM NC_011750.1 2731591 2732652 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease complement(2731591..2732652) Escherichia coli IAI39 7151396 YP_002408580.1 CDS yfgC NC_011750.1 2732865 2734328 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 2732865..2734328 Escherichia coli IAI39 7152369 YP_002408581.1 CDS yfgD NC_011750.1 2734349 2734708 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 2734349..2734708 Escherichia coli IAI39 7153879 YP_002408582.1 CDS hda NC_011750.1 2734814 2735560 R controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor complement(2734814..2735560) Escherichia coli IAI39 7153880 YP_002408583.1 CDS uraA NC_011750.1 2735610 2736899 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8332529, 7721693; Product type t : transporter; uracil transporter complement(2735610..2736899) Escherichia coli IAI39 7151617 YP_002408584.1 CDS upp NC_011750.1 2736985 2737611 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(2736985..2737611) Escherichia coli IAI39 7153106 YP_002408585.1 CDS purM NC_011750.1 2737936 2738973 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2737936..2738973 Escherichia coli IAI39 7153105 YP_002408586.1 CDS purN NC_011750.1 2738973 2739611 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 2738973..2739611 Escherichia coli IAI39 7152532 YP_002408587.1 CDS ppk NC_011750.1 2739783 2741849 D catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2739783..2741849 Escherichia coli IAI39 7152533 YP_002408588.1 CDS ppx NC_011750.1 2741854 2743395 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93107072, 94025037, 94165003, 8212131, 8380170; Product type e : enzyme; exopolyphosphatase 2741854..2743395 Escherichia coli IAI39 7152464 YP_002408589.1 CDS ECIAI39_2646 NC_011750.1 2745859 2746011 R hypothetical protein complement(2745859..2746011) Escherichia coli IAI39 7153882 YP_002408590.1 CDS yfgH NC_011750.1 2746531 2747049 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein 2746531..2747049 Escherichia coli IAI39 7149997 YP_002408591.1 CDS ECIAI39_2649 NC_011750.1 2747486 2747812 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 2747486..2747812 Escherichia coli IAI39 7153884 YP_002408592.1 CDS ECIAI39_2650 NC_011750.1 2747809 2748291 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 2747809..2748291 Escherichia coli IAI39 7149998 YP_002408593.1 CDS ECIAI39_2651 NC_011750.1 2748883 2750406 D Group II intron-encoded reverse transcriptase/maturase 2748883..2750406 Escherichia coli IAI39 7149999 YP_002408594.1 CDS ECIAI39_2652 NC_011750.1 2750523 2750969 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 2750523..2750969 Escherichia coli IAI39 7150537 YP_002408595.1 CDS ECIAI39_2654 NC_011750.1 2751408 2751890 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage lysis accessory protein complement(2751408..2751890) Escherichia coli IAI39 7153885 YP_002408596.1 CDS ECIAI39_2655 NC_011750.1 2751887 2752516 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage endolysin complement(2751887..2752516) Escherichia coli IAI39 7150002 YP_002408597.1 CDS ECIAI39_2656 NC_011750.1 2752801 2753205 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative integral membrane protein from phage origin complement(2752801..2753205) Escherichia coli IAI39 7150003 YP_002408598.1 CDS ECIAI39_2657 NC_011750.1 2753512 2756631 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 16689790; Product type e : enzyme; Endo-alpha-sialidase, phage head protein complement(2753512..2756631) Escherichia coli IAI39 7150004 YP_002408599.1 CDS ECIAI39_2658 NC_011750.1 2756704 2757084 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2756704..2757084 Escherichia coli IAI39 7150005 YP_002408600.1 CDS ECIAI39_2659 NC_011750.1 2757402 2758058 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage anti-repressor protein 2757402..2758058 Escherichia coli IAI39 7150006 YP_002408601.1 CDS ECIAI39_2660 NC_011750.1 2758288 2758923 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2758288..2758923 Escherichia coli IAI39 7150007 YP_002408602.1 CDS ECIAI39_2661 NC_011750.1 2759026 2759421 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(2759026..2759421) Escherichia coli IAI39 7150008 YP_002408603.1 CDS ECIAI39_2663 NC_011750.1 2761351 2761677 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 2761351..2761677 Escherichia coli IAI39 7150010 YP_002408604.1 CDS ECIAI39_2664 NC_011750.1 2761674 2762564 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 2761674..2762564 Escherichia coli IAI39 7150011 YP_002408605.1 CDS ECIAI39_2665 NC_011750.1 2762604 2762960 R transposase (fragment) complement(2762604..2762960) Escherichia coli IAI39 7150012 YP_002408606.1 CDS ECIAI39_2666 NC_011750.1 2762957 2763283 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 complement(2762957..2763283) Escherichia coli IAI39 7150013 YP_002408607.1 CDS ECIAI39_2668 NC_011750.1 2764146 2765948 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2764146..2765948) Escherichia coli IAI39 7150015 YP_002408608.1 CDS ECIAI39_2669 NC_011750.1 2765945 2768458 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2765945..2768458) Escherichia coli IAI39 7150016 YP_002408609.1 CDS ECIAI39_2670 NC_011750.1 2768471 2769010 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2768471..2769010) Escherichia coli IAI39 7150017 YP_002408610.1 CDS ECIAI39_2671 NC_011750.1 2769010 2769474 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2769010..2769474) Escherichia coli IAI39 7150018 YP_002408611.1 CDS ECIAI39_2672 NC_011750.1 2769474 2771945 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2769474..2771945) Escherichia coli IAI39 7150019 YP_002408612.1 CDS ECIAI39_2673 NC_011750.1 2771945 2772550 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2771945..2772550) Escherichia coli IAI39 7150020 YP_002408613.1 CDS ECIAI39_2674 NC_011750.1 2772550 2772879 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2772550..2772879) Escherichia coli IAI39 7150021 YP_002408614.1 CDS ECIAI39_2675 NC_011750.1 2772924 2773268 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2772924..2773268) Escherichia coli IAI39 7150022 YP_002408615.1 CDS ECIAI39_2676 NC_011750.1 2773270 2773707 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2773270..2773707) Escherichia coli IAI39 7150023 YP_002408616.1 CDS ECIAI39_2677 NC_011750.1 2773759 2774751 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2773759..2774751) Escherichia coli IAI39 7150024 YP_002408617.1 CDS ECIAI39_2678 NC_011750.1 2774760 2775455 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2774760..2775455) Escherichia coli IAI39 7150025 YP_002408618.1 CDS ECIAI39_2679 NC_011750.1 2775458 2775754 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2775458..2775754) Escherichia coli IAI39 7150026 YP_002408619.1 CDS ECIAI39_2680 NC_011750.1 2775751 2777430 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative head-to-tail-joining protein complement(2775751..2777430) Escherichia coli IAI39 7150027 YP_002408620.1 CDS ECIAI39_2681 NC_011750.1 2777445 2777651 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2777445..2777651) Escherichia coli IAI39 7150028 YP_002408621.1 CDS ECIAI39_2682 NC_011750.1 2777829 2777987 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2777829..2777987 Escherichia coli IAI39 7150029 YP_002408622.1 CDS ECIAI39_2683 NC_011750.1 2778452 2778799 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2778452..2778799 Escherichia coli IAI39 7150567 YP_002408623.1 CDS ECIAI39_2684 NC_011750.1 2778885 2780360 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage terminase, large subunit complement(2778885..2780360) Escherichia coli IAI39 7150031 YP_002408624.1 CDS ECIAI39_2685 NC_011750.1 2780357 2781031 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage terminase, small subunit complement(2780357..2781031) Escherichia coli IAI39 7150032 YP_002408625.1 CDS ECIAI39_2686 NC_011750.1 2781072 2781410 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2781072..2781410) Escherichia coli IAI39 7150033 YP_002408626.1 CDS ECIAI39_2687 NC_011750.1 2781403 2781840 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2781403..2781840) Escherichia coli IAI39 7150034 YP_002408627.1 CDS ECIAI39_2688 NC_011750.1 2781765 2782478 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2781765..2782478) Escherichia coli IAI39 7150035 YP_002408628.1 CDS ECIAI39_2689 NC_011750.1 2782489 2783244 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2782489..2783244) Escherichia coli IAI39 7150036 YP_002408629.1 CDS ECIAI39_2690 NC_011750.1 2783246 2783812 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2783246..2783812) Escherichia coli IAI39 7150037 YP_002408630.1 CDS ECIAI39_2691 NC_011750.1 2783809 2784384 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2783809..2784384) Escherichia coli IAI39 7150038 YP_002408631.1 CDS ECIAI39_2692 NC_011750.1 2784446 2784790 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2784446..2784790) Escherichia coli IAI39 7150039 YP_002408632.1 CDS ECIAI39_2693 NC_011750.1 2784908 2785702 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative replication protein P of bacteriophage complement(2784908..2785702) Escherichia coli IAI39 7150040 YP_002408633.1 CDS ECIAI39_2694 NC_011750.1 2785665 2786498 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative primosomal protein from phage complement(2785665..2786498) Escherichia coli IAI39 7150041 YP_002408634.1 CDS ECIAI39_2695 NC_011750.1 2786514 2786777 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2786514..2786777) Escherichia coli IAI39 7150042 YP_002408635.1 CDS ECIAI39_2696 NC_011750.1 2786865 2787095 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2786865..2787095) Escherichia coli IAI39 7150043 YP_002408636.1 CDS ECIAI39_2697 NC_011750.1 2787250 2787834 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative transcriptional repressor from phage origin 2787250..2787834 Escherichia coli IAI39 7150044 YP_002408637.1 CDS ECIAI39_2698 NC_011750.1 2788128 2788442 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2788128..2788442 Escherichia coli IAI39 7150045 YP_002408638.1 CDS ECIAI39_2700 NC_011750.1 2789230 2790174 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative recombination protein from phage 2789230..2790174 Escherichia coli IAI39 7150047 YP_002408639.1 CDS ECIAI39_2701 NC_011750.1 2790224 2790472 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator from phage origin 2790224..2790472 Escherichia coli IAI39 7150048 YP_002408640.1 CDS ECIAI39_2702 NC_011750.1 2790582 2790881 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional activator from phage origin 2790582..2790881 Escherichia coli IAI39 7150049 YP_002408641.1 CDS ECIAI39_2703 NC_011750.1 2790862 2791524 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative adenine methylase from phage origin 2790862..2791524 Escherichia coli IAI39 7150050 YP_002408642.1 CDS ECIAI39_2704 NC_011750.1 2791719 2792969 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative integrase complement(2791719..2792969) Escherichia coli IAI39 7150051 YP_002408643.1 CDS guaA NC_011750.1 2793162 2794739 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(2793162..2794739) Escherichia coli IAI39 7150052 YP_002408644.1 CDS guaB NC_011750.1 2794808 2796274 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(2794808..2796274) Escherichia coli IAI39 7151596 YP_002408645.1 CDS xseA NC_011750.1 2796436 2797803 D bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2796436..2797803 Escherichia coli IAI39 7151597 YP_002408646.1 CDS ECIAI39_2708 NC_011750.1 2797857 2805932 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2797857..2805932) Escherichia coli IAI39 7153182 YP_002408647.1 CDS ECIAI39_2709 NC_011750.1 2806042 2807019 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2806042..2807019) Escherichia coli IAI39 7150053 YP_002408648.1 CDS ECIAI39_2710 NC_011750.1 2807069 2809273 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8500884, 3304658, 12540539; Product type pf : putative factor; putative intimin complement(2807069..2809273) Escherichia coli IAI39 7150054 YP_002408649.1 CDS ECIAI39_2711 NC_011750.1 2809453 2809668 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2809453..2809668) Escherichia coli IAI39 7150055 YP_002408650.1 CDS engA NC_011750.1 2809731 2811203 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(2809731..2811203) Escherichia coli IAI39 7150056 YP_002408651.1 CDS yfgL NC_011750.1 2811321 2812499 R with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL complement(2811321..2812499) Escherichia coli IAI39 7151123 YP_002408652.1 CDS yfgM NC_011750.1 2812510 2813130 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2812510..2813130) Escherichia coli IAI39 7153886 YP_002408653.1 CDS hisS NC_011750.1 2813148 2814422 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(2813148..2814422) Escherichia coli IAI39 7153887 YP_002408654.1 CDS ispG NC_011750.1 2814533 2815651 R catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase complement(2814533..2815651) Escherichia coli IAI39 7150538 YP_002408655.1 CDS yfgA NC_011750.1 2815678 2816688 R Evidence 4 : Homologs of previously reported genes of unknown function; cytoskeletal protein RodZ complement(2815678..2816688) Escherichia coli IAI39 7151856 YP_002408656.1 CDS yfgB NC_011750.1 2816973 2818127 R 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N complement(2816973..2818127) Escherichia coli IAI39 7153877 YP_002408657.1 CDS ndk NC_011750.1 2818277 2818708 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(2818277..2818708) Escherichia coli IAI39 7153878 YP_002408658.1 CDS pbpC NC_011750.1 2818857 2821169 R penicillin-insensitive transglycosylase/transpeptidase; penicillin-binding protein 1C complement(2818857..2821169) Escherichia coli IAI39 7152203 YP_002408659.1 CDS yfhM NC_011750.1 2821170 2826128 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2821170..2826128) Escherichia coli IAI39 7152349 YP_002408660.1 CDS sseA NC_011750.1 2826335 2827180 D catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 2826335..2827180 Escherichia coli IAI39 7153896 YP_002408661.1 CDS sseB NC_011750.1 2827677 2828453 R enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB complement(2827677..2828453) Escherichia coli IAI39 7152785 YP_002408662.1 CDS pepB NC_011750.1 2828572 2829855 R catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase B complement(2828572..2829855) Escherichia coli IAI39 7152904 YP_002408663.1 CDS yfhJ NC_011750.1 2829914 2830114 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10393315; Product type pf : putative factor; hypothetical protein complement(2829914..2830114) Escherichia coli IAI39 7152362 YP_002408664.1 CDS fdx NC_011750.1 2830126 2830461 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10393315, 20013001, 92283811, 94181532, 11551196, 1317854, 4375562, 8300516; Product type c : carrier; [2Fe-2S] ferredoxin complement(2830126..2830461) Escherichia coli IAI39 7153893 YP_002408665.1 CDS hscA NC_011750.1 2830463 2832313 R involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA complement(2830463..2832313) Escherichia coli IAI39 7151293 YP_002408666.1 CDS hscB NC_011750.1 2832316 2832846 R J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB complement(2832316..2832846) Escherichia coli IAI39 7151675 YP_002408667.1 CDS iscA NC_011750.1 2832942 2833265 R forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein complement(2832942..2833265) Escherichia coli IAI39 7151676 YP_002408668.1 CDS iscU NC_011750.1 2833282 2833668 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10393315, 11994302, 15153099; Product type f : factor; scaffold protein complement(2833282..2833668) Escherichia coli IAI39 7151846 YP_002408669.1 CDS iscS NC_011750.1 2833696 2834910 R catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase complement(2833696..2834910) Escherichia coli IAI39 7151849 YP_002408670.1 CDS iscR NC_011750.1 2835022 2835510 R regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR complement(2835022..2835510) Escherichia coli IAI39 7151848 YP_002408671.1 CDS yfhQ NC_011750.1 2835781 2836521 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10393315; Product type pe : putative enzyme; putative methyltransferase complement(2835781..2836521) Escherichia coli IAI39 7151847 YP_002408672.1 CDS suhB NC_011750.1 2836640 2837443 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6389495, 90202735, 95095968, 10747806, 2138605, 8002619; Product type e : enzyme; inositol monophosphatase 2836640..2837443 Escherichia coli IAI39 7153897 YP_002408673.1 CDS yfhR NC_011750.1 2837561 2838442 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidase 2837561..2838442 Escherichia coli IAI39 7152930 YP_002408674.1 CDS csiE NC_011750.1 2838633 2839913 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95020540, 96154950; Product type cp : cell process; stationary phase inducible protein CsiE 2838633..2839913 Escherichia coli IAI39 7153898 YP_002408675.1 CDS hcaT NC_011750.1 2839905 2841044 R putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; putative 3-phenylpropionic acid transporter complement(2839905..2841044) Escherichia coli IAI39 7151010 YP_002408676.1 CDS hcaR NC_011750.1 2841204 2842094 R activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional regulator HcaR complement(2841204..2842094) Escherichia coli IAI39 7151613 YP_002408677.1 CDS hcaE NC_011750.1 2842230 2843591 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83238171, 87008429, 98269008; Product type e : enzyme; 3-phenylpropionate dioxygenase large subunit alpha 2842230..2843591 Escherichia coli IAI39 7151612 YP_002408678.1 CDS hcaF NC_011750.1 2843588 2844106 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83238171, 87008429, 98269008, 9603882; Product type e : enzyme; 3-phenylpropionate dioxygenase subunit beta 2843588..2844106 Escherichia coli IAI39 7151610 YP_002408679.1 CDS hcaC NC_011750.1 2844106 2844426 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98269008, 9603882; Product type pc : putative carrier; 3-phenylpropionate dioxygenase ferredoxin subunit 2844106..2844426 Escherichia coli IAI39 7151611 YP_002408680.1 CDS hcaB NC_011750.1 2844423 2845235 D Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 2844423..2845235 Escherichia coli IAI39 7151608 YP_002408681.1 CDS hcaD NC_011750.1 2845245 2846447 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98269008, 9603882; Product type e : enzyme; phenylpropionate dioxygenase ferredoxin reductase subunit 2845245..2846447 Escherichia coli IAI39 7151607 YP_002408682.1 CDS yphA NC_011750.1 2846472 2846966 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2846472..2846966 Escherichia coli IAI39 7151609 YP_002408683.1 CDS ECIAI39_2745 NC_011750.1 2847033 2847563 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 2847033..2847563 Escherichia coli IAI39 7154484 YP_002408684.1 CDS ECIAI39_2746 NC_011750.1 2847668 2848390 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 2847668..2848390 Escherichia coli IAI39 7150057 YP_002408685.1 CDS yphB NC_011750.1 2848450 2849322 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2848450..2849322) Escherichia coli IAI39 7150058 YP_002408686.1 CDS yphC NC_011750.1 2849334 2850395 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(2849334..2850395) Escherichia coli IAI39 7154485 YP_002408687.1 CDS yphD NC_011750.1 2850461 2851459 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter membrane protein complement(2850461..2851459) Escherichia coli IAI39 7154486 YP_002408688.1 CDS yphE NC_011750.1 2851484 2852995 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; sugar ABC transporter ATP-binding protein complement(2851484..2852995) Escherichia coli IAI39 7154487 YP_002408689.1 CDS yphF NC_011750.1 2853018 2854001 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pt : putative transporter; putative sugar ABC transporter periplasmic-binding protein complement(2853018..2854001) Escherichia coli IAI39 7154488 YP_002408690.1 CDS yphG NC_011750.1 2854098 2857379 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2854098..2857379) Escherichia coli IAI39 7154489 YP_002408691.1 CDS yphH NC_011750.1 2857497 2858690 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2857497..2858690 Escherichia coli IAI39 7154490 YP_002408692.1 CDS glyA NC_011750.1 2858753 2860006 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(2858753..2860006) Escherichia coli IAI39 7154491 YP_002408693.1 CDS ECIAI39_2755 NC_011750.1 2860047 2860223 R hypothetical protein complement(2860047..2860223) Escherichia coli IAI39 7151559 YP_002408694.1 CDS hmp NC_011750.1 2860334 2861524 D flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 2860334..2861524 Escherichia coli IAI39 7150059 YP_002408695.1 CDS glnB NC_011750.1 2861569 2861907 R indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 complement(2861569..2861907) Escherichia coli IAI39 7151662 YP_002408696.1 CDS yfhA NC_011750.1 2861968 2863302 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8226691, 8412694; Product type pr : putative regulator; putative DNA-binding response regulator in two-component system complement(2861968..2863302) Escherichia coli IAI39 7151524 YP_002408697.1 CDS yfhG NC_011750.1 2863292 2864005 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2863292..2864005) Escherichia coli IAI39 7153888 YP_002408698.1 CDS yfhK NC_011750.1 2864170 2865597 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative sensory kinase in two-component system complement(2864170..2865597) Escherichia coli IAI39 7153891 YP_002408699.1 CDS purL NC_011750.1 2866175 2870062 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase complement(2866175..2870062) Escherichia coli IAI39 7152988 YP_002408700.1 CDS yfhD NC_011750.1 2870458 2871876 D YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; putative transglycosylase 2870458..2871876 Escherichia coli IAI39 7152531 YP_002408701.1 CDS tadA NC_011750.1 2871873 2872409 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12110595; Product type e : enzyme; tRNA-specific adenosine deaminase complement(2871873..2872409) Escherichia coli IAI39 7153890 YP_002408702.1 CDS yfhB NC_011750.1 2872434 2873069 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2872434..2873069) Escherichia coli IAI39 7152936 YP_002408703.1 CDS yfhH NC_011750.1 2873278 2874126 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2873278..2874126 Escherichia coli IAI39 7153889 YP_002408704.1 CDS yfhL NC_011750.1 2874182 2874442 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8765743, 8880900; Product type c : carrier; ferredoxin 2874182..2874442 Escherichia coli IAI39 7153892 YP_002408705.1 CDS ECIAI39_2767 NC_011750.1 2874713 2874877 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2874713..2874877) Escherichia coli IAI39 7152786 YP_002408706.1 CDS acpS NC_011750.1 2875138 2875518 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(2875138..2875518) Escherichia coli IAI39 7152787 YP_002408707.1 CDS pdxJ NC_011750.1 2875518 2876249 R involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase complement(2875518..2876249) Escherichia coli IAI39 7150670 YP_002408708.1 CDS recO NC_011750.1 2876261 2876989 R involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO complement(2876261..2876989) Escherichia coli IAI39 7152358 YP_002408709.1 CDS era NC_011750.1 2877001 2877906 R Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era complement(2877001..2877906) Escherichia coli IAI39 7152595 YP_002408710.1 CDS rnc NC_011750.1 2877903 2878583 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(2877903..2878583) Escherichia coli IAI39 7151238 YP_002408711.1 CDS lepB NC_011750.1 2878856 2879830 R catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I complement(2878856..2879830) Escherichia coli IAI39 7150540 YP_002408712.1 CDS lepA NC_011750.1 2879846 2881645 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(2879846..2881645) Escherichia coli IAI39 7151923 YP_002408713.1 CDS rseC NC_011750.1 2881843 2882322 R involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC complement(2881843..2882322) Escherichia coli IAI39 7151922 YP_002408714.1 CDS rseB NC_011750.1 2882319 2883275 R periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE complement(2882319..2883275) Escherichia coli IAI39 7152740 YP_002408715.1 CDS rseA NC_011750.1 2883275 2883925 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9159522, 97303092, 99431977, 7768826; Product type f : factor; anti-RNA polymerase sigma factor SigE complement(2883275..2883925) Escherichia coli IAI39 7152739 YP_002408716.1 CDS rpoE NC_011750.1 2883958 2884533 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE complement(2883958..2884533) Escherichia coli IAI39 7152738 YP_002408717.1 CDS nadB NC_011750.1 2884941 2886563 D catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 2884941..2886563 Escherichia coli IAI39 7152707 YP_002408718.1 CDS yfiC NC_011750.1 2886548 2887285 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative S-adenosyl-L-methionine-dependent methyltransferase complement(2886548..2887285) Escherichia coli IAI39 7152166 YP_002408719.1 CDS srmB NC_011750.1 2887417 2888751 D facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2887417..2888751 Escherichia coli IAI39 7153901 YP_002408720.1 CDS ECIAI39_2782 NC_011750.1 2888932 2889462 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 2888932..2889462 Escherichia coli IAI39 7152901 YP_002408721.1 CDS ECIAI39_2783 NC_011750.1 2889567 2890289 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 2889567..2890289 Escherichia coli IAI39 7150061 YP_002408722.1 CDS yfiK NC_011750.1 2891379 2891966 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12562784; Product type t : transporter; neutral amino-acid efflux protein 2891379..2891966 Escherichia coli IAI39 7153904 YP_002408723.1 CDS yfiD NC_011750.1 2892021 2892404 R stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA complement(2892021..2892404) Escherichia coli IAI39 7153907 YP_002408724.1 CDS ung NC_011750.1 2892709 2893398 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2892709..2893398 Escherichia coli IAI39 7153902 YP_002408725.1 CDS yfiF NC_011750.1 2893446 2894483 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase complement(2893446..2894483) Escherichia coli IAI39 7153104 YP_002408726.1 CDS trxC NC_011750.1 2894690 2895109 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12952960, 9388228, 99175138, 10644706; Product type c : carrier; thioredoxin 2 2894690..2895109 Escherichia coli IAI39 7153905 YP_002408727.1 CDS yfiP NC_011750.1 2895178 2895876 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2895178..2895876 Escherichia coli IAI39 7153045 YP_002408728.1 CDS yfiQ NC_011750.1 2895908 2898568 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; fused acyl-CoA synthetase: NAD(P)-binding subunit ; ATP-binding subunit 2895908..2898568 Escherichia coli IAI39 7153911 YP_002408729.1 CDS pssA NC_011750.1 2898682 2900037 D catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 2898682..2900037 Escherichia coli IAI39 7153912 YP_002408730.1 CDS yfiM NC_011750.1 2900134 2900406 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2900134..2900406 Escherichia coli IAI39 7152508 YP_002408731.1 CDS kgtP NC_011750.1 2900403 2901701 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91219460, 1709493, 2053984, 2118499, 2190187, 8419306; Product type t : transporter; alpha-ketoglutarate transporter complement(2900403..2901701) Escherichia coli IAI39 7153908 YP_002408732.1 CDS ECIAI39_2796 NC_011750.1 2901760 2901942 D hypothetical protein 2901760..2901942 Escherichia coli IAI39 7151898 YP_002408733.1 CDS clpB NC_011750.1 2907469 2910042 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14550559, 14640692, 91294166, 93015925, 93388583, 99428468; Product type f : factor; protein disaggregation chaperone complement(2907469..2910042) Escherichia coli IAI39 7149777 YP_002408734.1 CDS yfiH NC_011750.1 2910172 2910903 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1906060, 2066329; hypothetical protein complement(2910172..2910903) Escherichia coli IAI39 7152788 YP_002408735.1 CDS rluD NC_011750.1 2910900 2911880 R responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D complement(2910900..2911880) Escherichia coli IAI39 7153906 YP_002408736.1 CDS yfiO NC_011750.1 2912015 2912752 D with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 2912015..2912752 Escherichia coli IAI39 7152644 YP_002408737.1 CDS insG NC_011750.1 2912802 2914148 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element complement(2912802..2914148) Escherichia coli IAI39 7153910 YP_002408738.1 CDS yfiA NC_011750.1 2914461 2914802 D associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 2914461..2914802 Escherichia coli IAI39 7151811 YP_002408740.1 CDS pheA NC_011750.1 2915052 2916212 D catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 2915052..2916212 Escherichia coli IAI39 7152389 YP_002408741.1 CDS tyrA NC_011750.1 2916255 2917376 R catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase complement(2916255..2917376) Escherichia coli IAI39 7152388 YP_002408742.1 CDS aroF NC_011750.1 2917387 2918457 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(2917387..2918457) Escherichia coli IAI39 7153062 YP_002408743.1 CDS ECIAI39_2806 NC_011750.1 2918491 2919030 D hypothetical protein 2918491..2919030 Escherichia coli IAI39 7150780 YP_002408744.1 CDS yfiR NC_011750.1 2919180 2919698 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2919180..2919698 Escherichia coli IAI39 7150064 YP_002408745.1 CDS yfiN NC_011750.1 2919688 2920914 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; hypothetical protein 2919688..2920914 Escherichia coli IAI39 7153913 YP_002408746.1 CDS yfiB NC_011750.1 2920930 2921412 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96032391; Product type pm : putative membrane component; putative outer membrane lipoprotein 2920930..2921412 Escherichia coli IAI39 7153909 YP_002408747.1 CDS rplS NC_011750.1 2921489 2921836 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(2921489..2921836) Escherichia coli IAI39 7153900 YP_002408748.1 CDS trmD NC_011750.1 2921878 2922645 R methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase complement(2921878..2922645) Escherichia coli IAI39 7152687 YP_002408749.1 CDS rimM NC_011750.1 2922676 2923224 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(2922676..2923224) Escherichia coli IAI39 7153027 YP_002408750.1 CDS rpsP NC_011750.1 2923243 2923491 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(2923243..2923491) Escherichia coli IAI39 7152637 YP_002408751.1 CDS ffh NC_011750.1 2923628 2924989 R with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein complement(2923628..2924989) Escherichia coli IAI39 7152728 YP_002408752.1 CDS ypjD NC_011750.1 2925081 2925947 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2925081..2925947 Escherichia coli IAI39 7151310 YP_002408753.1 CDS yfjD NC_011750.1 2926058 2927254 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2926058..2927254 Escherichia coli IAI39 7154495 YP_002408754.1 CDS grpE NC_011750.1 2927309 2927902 R with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(2927309..2927902) Escherichia coli IAI39 7153915 YP_002408755.1 CDS ppnK NC_011750.1 2928026 2928904 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 2928026..2928904 Escherichia coli IAI39 7151587 YP_002408756.1 CDS recN NC_011750.1 2928990 2930651 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87259985, 91355307, 95058623, 3037486; Product type cp : cell process; recombination and repair protein 2928990..2930651 Escherichia coli IAI39 7153914 YP_002408757.1 CDS smpA NC_011750.1 2930800 2931141 D Evidence 2b : Function of strongly homologous gene; PubMedId : 2045357; Product type lp : lipoprotein; hypothetical protein 2930800..2931141 Escherichia coli IAI39 7152594 YP_002408758.1 CDS yfjF NC_011750.1 2931203 2931493 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2931203..2931493) Escherichia coli IAI39 7152867 YP_002408759.1 CDS yfjG NC_011750.1 2931483 2931959 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2931483..2931959) Escherichia coli IAI39 7153916 YP_002408760.1 CDS smpB NC_011750.1 2932091 2932573 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 2932091..2932573 Escherichia coli IAI39 7153917 YP_002408761.1 CDS ECIAI39_2824 NC_011750.1 2933379 2934593 D Type-2 restriction enzyme EcoRII (R.EcoRII) (Type II restriction enzyme EcoRII) (Endonuclease EcoRII) 2933379..2934593 Escherichia coli IAI39 7152908 YP_002408762.1 CDS ECIAI39_2825 NC_011750.1 2934628 2936103 R DNA cytosine methylase complement(2934628..2936103) Escherichia coli IAI39 7150065 YP_002408763.1 CDS ECIAI39_2826 NC_011750.1 2936413 2937237 D hypothetical protein 2936413..2937237 Escherichia coli IAI39 7150066 YP_002408764.1 CDS ECIAI39_2827 NC_011750.1 2938106 2938267 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2938106..2938267) Escherichia coli IAI39 7150067 YP_002408765.1 CDS ECIAI39_2828 NC_011750.1 2938704 2939114 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber assembly protein (possibly partial) complement(2938704..2939114) Escherichia coli IAI39 7150068 YP_002408766.1 CDS ECIAI39_2829 NC_011750.1 2939099 2940049 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2939099..2940049) Escherichia coli IAI39 7150069 YP_002408767.1 CDS ymfQ NC_011750.1 2940053 2940637 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2940053..2940637) Escherichia coli IAI39 7150070 YP_002408768.1 CDS ECIAI39_2831 NC_011750.1 2940628 2941686 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative baseplate J-like phage protein complement(2940628..2941686) Escherichia coli IAI39 7154391 YP_002408769.1 CDS ECIAI39_2832 NC_011750.1 2941673 2942101 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail protein complement(2941673..2942101) Escherichia coli IAI39 7150071 YP_002408770.1 CDS ECIAI39_2833 NC_011750.1 2942098 2942646 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative baseplate assembly phage protein complement(2942098..2942646) Escherichia coli IAI39 7150072 YP_002408771.1 CDS ECIAI39_2834 NC_011750.1 2942646 2943725 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail protein complement(2942646..2943725) Escherichia coli IAI39 7150073 YP_002408772.1 CDS ECIAI39_2835 NC_011750.1 2943722 2945092 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail/DNA circulation protein complement(2943722..2945092) Escherichia coli IAI39 7150074 YP_002408773.1 CDS ECIAI39_2836 NC_011750.1 2945111 2946016 R Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; tail protein from Bacteriophage (fragment) complement(2945111..2946016) Escherichia coli IAI39 7150075 YP_002408774.1 CDS ECIAI39_2837 NC_011750.1 2945982 2946872 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 complement(2945982..2946872) Escherichia coli IAI39 7150076 YP_002408775.1 CDS ECIAI39_2838 NC_011750.1 2946869 2947195 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 complement(2946869..2947195) Escherichia coli IAI39 7150077 YP_002408776.1 CDS pinH NC_011750.1 2949057 2949323 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative invertase fragment (fragment) complement(2949057..2949323) Escherichia coli IAI39 7154492 YP_002408777.1 CDS ECIAI39_2843 NC_011750.1 2951630 2951959 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2951630..2951959) Escherichia coli IAI39 7154494 YP_002408778.1 CDS ECIAI39_2844 NC_011750.1 2952498 2954750 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative alpha-amylase 2952498..2954750 Escherichia coli IAI39 7150612 YP_002408779.1 CDS ygaT NC_011750.1 2955087 2956064 D in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 2955087..2956064 Escherichia coli IAI39 7150080 YP_002408780.1 CDS ygaF NC_011750.1 2956084 2957352 D catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 2956084..2957352 Escherichia coli IAI39 7153924 YP_002408781.1 CDS gabD NC_011750.1 2957375 2958823 D catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; succinate-semialdehyde dehydrogenase I 2957375..2958823 Escherichia coli IAI39 7153920 YP_002408782.1 CDS gabT NC_011750.1 2958837 2960117 D catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 2958837..2960117 Escherichia coli IAI39 7151460 YP_002408783.1 CDS ECIAI39_2849 NC_011750.1 2960178 2960900 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group complement(2960178..2960900) Escherichia coli IAI39 7151462 YP_002408784.1 CDS ECIAI39_2850 NC_011750.1 2961005 2961535 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 complement(2961005..2961535) Escherichia coli IAI39 7150081 YP_002408785.1 CDS gabP NC_011750.1 2961789 2963189 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94127927, 9685361, 8297211; Product type t : transporter; gamma-aminobutyrate transporter 2961789..2963189 Escherichia coli IAI39 7150082 YP_002408786.1 CDS csiR NC_011750.1 2963210 2963872 D regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 2963210..2963872 Escherichia coli IAI39 7151461 YP_002408787.1 CDS ygaU NC_011750.1 2963873 2964322 R Evidence 4 : Homologs of previously reported genes of unknown function; LysM domain/BON superfamily protein complement(2963873..2964322) Escherichia coli IAI39 7151011 YP_002408788.1 CDS yqaE NC_011750.1 2964406 2964564 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2964406..2964564) Escherichia coli IAI39 7153925 YP_002408789.1 CDS ygaV NC_011750.1 2964747 2965046 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 2964747..2965046 Escherichia coli IAI39 7154498 YP_002408790.1 CDS ygaP NC_011750.1 2965056 2965580 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : putative enzyme; hypothetical protein 2965056..2965580 Escherichia coli IAI39 7153926 YP_002408791.1 CDS stpA NC_011750.1 2965627 2966031 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20485613, 93126121, 9643551, 98132400, 99415935, 1480493, 7961433; Product type r : regulator; DNA binding protein, nucleoid-associated complement(2965627..2966031) Escherichia coli IAI39 7153923 YP_002408792.1 CDS ygaW NC_011750.1 2966698 2967147 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2966698..2967147 Escherichia coli IAI39 7152917 YP_002408793.1 CDS ygaC NC_011750.1 2967184 2967528 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7961433; hypothetical protein complement(2967184..2967528) Escherichia coli IAI39 7153927 YP_002408794.1 CDS ygaM NC_011750.1 2967668 2968009 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2967668..2968009 Escherichia coli IAI39 7153918 YP_002408795.1 CDS ECIAI39_2861 NC_011750.1 2968066 2969400 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; bifunctional aminotransaminase/GntR family transcriptional regulator complement(2968066..2969400) Escherichia coli IAI39 7153922 YP_002408796.1 CDS ECIAI39_2862 NC_011750.1 2969488 2969919 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2969488..2969919 Escherichia coli IAI39 7150083 YP_002408797.1 CDS nrdH NC_011750.1 2970128 2970373 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9218434, 11441020, 8820648; Product type pc : putative carrier; glutaredoxin-like protein 2970128..2970373 Escherichia coli IAI39 7150084 YP_002408798.1 CDS nrdI NC_011750.1 2970370 2970780 D in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 2970370..2970780 Escherichia coli IAI39 7152250 YP_002408799.1 CDS nrdE NC_011750.1 2970753 2972897 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2970753..2972897 Escherichia coli IAI39 7152251 YP_002408800.1 CDS nrdF NC_011750.1 2972907 2973866 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 2972907..2973866 Escherichia coli IAI39 7152247 YP_002408801.1 CDS proV NC_011750.1 2974222 2975424 D with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding subunit 2974222..2975424 Escherichia coli IAI39 7152248 YP_002408802.1 CDS proW NC_011750.1 2975417 2976481 D with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 2975417..2976481 Escherichia coli IAI39 7152489 YP_002408803.1 CDS proX NC_011750.1 2976538 2977530 D with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 2976538..2977530 Escherichia coli IAI39 7152490 YP_002408804.1 CDS ECIAI39_2870 NC_011750.1 2977722 2978906 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16000740; Product type pt : putative transporter; putative transport protein (ousB-like) 2977722..2978906 Escherichia coli IAI39 7152491 YP_002408805.1 CDS ygaZ NC_011750.1 2979030 2979767 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 2979030..2979767 Escherichia coli IAI39 7150085 YP_002408806.1 CDS ygaH NC_011750.1 2979757 2980092 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 2979757..2980092 Escherichia coli IAI39 7153928 YP_002408807.1 CDS mprA NC_011750.1 2980183 2980713 D DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 2980183..2980713 Escherichia coli IAI39 7153921 YP_002408808.1 CDS ECIAI39_2874 NC_011750.1 2980795 2982141 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase, IS4 complement(2980795..2982141) Escherichia coli IAI39 7152116 YP_002408809.1 CDS emrA NC_011750.1 2982278 2983450 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 93285984, 94262163, 1409590, 8203018; Product type t : transporter; multidrug efflux system 2982278..2983450 Escherichia coli IAI39 7150086 YP_002408810.1 CDS emrB NC_011750.1 2983467 2985005 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 93285984, 94262163, 1409590; Product type t : transporter; multidrug efflux system protein 2983467..2985005 Escherichia coli IAI39 7151214 YP_002408811.1 CDS luxS NC_011750.1 2985069 2985584 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(2985069..2985584) Escherichia coli IAI39 7151215 YP_002408812.1 CDS gshA NC_011750.1 2985734 2987290 R involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase complement(2985734..2987290) Escherichia coli IAI39 7152080 YP_002408813.1 CDS yqaA NC_011750.1 2987363 2987791 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(2987363..2987791) Escherichia coli IAI39 7151591 YP_002408814.1 CDS yqaB NC_011750.1 2987788 2988354 R YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase complement(2987788..2988354) Escherichia coli IAI39 7154496 YP_002408815.1 CDS csrA NC_011750.1 2989411 2989596 R affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator complement(2989411..2989596) Escherichia coli IAI39 7150607 YP_002408816.1 CDS alaS NC_011750.1 2989831 2992461 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(2989831..2992461) Escherichia coli IAI39 7151021 YP_002408817.1 CDS recX NC_011750.1 2992590 2993090 R binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX complement(2992590..2993090) Escherichia coli IAI39 7150710 YP_002408818.1 CDS recA NC_011750.1 2993159 2994220 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(2993159..2994220) Escherichia coli IAI39 7152598 YP_002408819.1 CDS ygaD NC_011750.1 2994300 2994797 R Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A complement(2994300..2994797) Escherichia coli IAI39 7152587 YP_002408820.1 CDS mltB NC_011750.1 2994942 2996027 R membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B complement(2994942..2996027) Escherichia coli IAI39 7153919 YP_002408821.1 CDS srlA NC_011750.1 2996283 2996846 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87194727, 1334233, 3553176; Product type t : transporter; PTS system glucitol/sorbitol-specific transporter subunit IIC 2996283..2996846 Escherichia coli IAI39 7152090 YP_002408822.1 CDS srlE NC_011750.1 2996843 2997802 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1100602, 3553176; Product type t : transporter; PTS system glucitol/sorbitol-specific transporter subunit IIB 2996843..2997802 Escherichia coli IAI39 7152896 YP_002408823.1 CDS srlB NC_011750.1 2997813 2998184 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucitol/sorbitol-specific transporter subunit IIA 2997813..2998184 Escherichia coli IAI39 7152899 YP_002408824.1 CDS srlD NC_011750.1 2998188 2998967 D catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 2998188..2998967 Escherichia coli IAI39 7152897 YP_002408825.1 CDS gutM NC_011750.1 2999073 2999432 D regulator for glucitol utilization; DNA-binding transcriptional activator GutM 2999073..2999432 Escherichia coli IAI39 7152898 YP_002408826.1 CDS srlR NC_011750.1 2999499 3000272 D regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 2999499..3000272 Escherichia coli IAI39 7151603 YP_002408827.1 CDS gutQ NC_011750.1 3000265 3001230 D catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 3000265..3001230 Escherichia coli IAI39 7152900 YP_002408828.1 CDS norR NC_011750.1 3001227 3002741 R Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcription regulator complement(3001227..3002741) Escherichia coli IAI39 7151604 YP_002408829.1 CDS norV NC_011750.1 3002928 3004367 D detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 3002928..3004367 Escherichia coli IAI39 7152240 YP_002408830.1 CDS norW NC_011750.1 3004364 3005497 D catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 3004364..3005497 Escherichia coli IAI39 7152241 YP_002408831.1 CDS hypF NC_011750.1 3005576 3007888 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12377778, 92255260, 8661925; Product type e : enzyme; carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases complement(3005576..3007888) Escherichia coli IAI39 7152242 YP_002408832.1 CDS hydN NC_011750.1 3007969 3008496 R involved in electron transport from formate to hydrogen; electron transport protein HydN complement(3007969..3008496) Escherichia coli IAI39 7151738 YP_002408833.1 CDS ascG NC_011750.1 3008645 3009658 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88297127, 92334140, 1630307; Product type r : regulator; DNA-binding transcriptional repressor complement(3008645..3009658) Escherichia coli IAI39 7151720 YP_002408834.1 CDS ascF NC_011750.1 3009914 3011371 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC 3009914..3011371 Escherichia coli IAI39 7150797 YP_002408835.1 CDS ascB NC_011750.1 3011380 3012804 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88297127, 92334140, 1630307; Product type e : enzyme; cryptic 6-phospho-beta-glucosidase 3011380..3012804 Escherichia coli IAI39 7150796 YP_002408836.1 CDS ECIAI39_2903 NC_011750.1 3012861 3013583 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group complement(3012861..3013583) Escherichia coli IAI39 7150795 YP_002408837.1 CDS ECIAI39_2904 NC_011750.1 3013688 3014218 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 complement(3013688..3014218) Escherichia coli IAI39 7150087 YP_002408838.1 CDS hycI NC_011750.1 3014398 3014868 R involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease complement(3014398..3014868) Escherichia coli IAI39 7150088 YP_002408839.1 CDS hycH NC_011750.1 3014861 3015271 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 92326636, 1625581, 2187144, 7851435; Product type f : factor; hydrogenase 3 maturation protein complement(3014861..3015271) Escherichia coli IAI39 7151719 YP_002408840.1 CDS hycG NC_011750.1 3015268 3016035 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636, 2187144; Product type e : enzyme; hydrogenase 3 and formate hydrogenase complex subunit HycG complement(3015268..3016035) Escherichia coli IAI39 7151718 YP_002408841.1 CDS hycF NC_011750.1 3016035 3016577 R electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; formate hydrogenlyase complex iron-sulfur subunit complement(3016035..3016577) Escherichia coli IAI39 7151717 YP_002408842.1 CDS hycE NC_011750.1 3016587 3018296 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 92326636, 94170785, 2187144, 8125094; Product type e : enzyme; hydrogenase 3, large subunit complement(3016587..3018296) Escherichia coli IAI39 7151716 YP_002408843.1 CDS hycD NC_011750.1 3018314 3019237 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636; Product type m : membrane component; hydrogenase 3, membrane subunit complement(3018314..3019237) Escherichia coli IAI39 7151715 YP_002408844.1 CDS hycC NC_011750.1 3019240 3021066 R catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 complement(3019240..3021066) Escherichia coli IAI39 7151714 YP_002408845.1 CDS hycB NC_011750.1 3021063 3021674 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636, 2187144; Product type c : carrier; hydrogenase 3, Fe-S subunit complement(3021063..3021674) Escherichia coli IAI39 7151713 YP_002408846.1 CDS hycA NC_011750.1 3021799 3022260 R regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA complement(3021799..3022260) Escherichia coli IAI39 7151712 YP_002408847.1 CDS hypA NC_011750.1 3022472 3022822 D plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 3022472..3022822 Escherichia coli IAI39 7151711 YP_002408848.1 CDS hypB NC_011750.1 3022826 3023698 D GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 3022826..3023698 Escherichia coli IAI39 7151733 YP_002408849.1 CDS hypC NC_011750.1 3023689 3023961 D HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 3023689..3023961 Escherichia coli IAI39 7151734 YP_002408850.1 CDS hypD NC_011750.1 3023961 3025082 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91194542, 92255260, 1849603; Product type f : factor; hydrogenase maturation protein 3023961..3025082 Escherichia coli IAI39 7151735 YP_002408851.1 CDS hypE NC_011750.1 3025121 3026089 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91194542, 9485446, 1849603; Product type e : enzyme; carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein 3025121..3026089 Escherichia coli IAI39 7151736 YP_002408852.1 CDS fhlA NC_011750.1 3026163 3028241 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20307603, 21557168, 90368529, 92140045, 94018617, 2118503, 2280686; Product type r : regulator; DNA-binding transcriptional activator 3026163..3028241 Escherichia coli IAI39 7151737 YP_002408853.1 CDS ECIAI39_2921 NC_011750.1 3028247 3028714 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative molybdenum-pterin-binding-protein 3028247..3028714 Escherichia coli IAI39 7151313 YP_002408854.1 CDS ygbA NC_011750.1 3028753 3029097 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3028753..3029097) Escherichia coli IAI39 7150089 YP_002408855.1 CDS mutS NC_011750.1 3029384 3031945 D This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 3029384..3031945 Escherichia coli IAI39 7153929 YP_002408856.1 CDS pphB NC_011750.1 3032051 3032707 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9130712; Product type e : enzyme; serine/threonine-specific protein phosphatase 2 3032051..3032707 Escherichia coli IAI39 7152158 YP_002408857.1 CDS ECIAI39_2925 NC_011750.1 3032749 3032985 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme; putative non-oxidative hydroxyarylic acid decarboxylase complement(3032749..3032985) Escherichia coli IAI39 7152459 YP_002408858.1 CDS ECIAI39_2926 NC_011750.1 3032996 3034423 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme; putative non-oxidative hydroxyarylic acid decarboxylase complement(3032996..3034423) Escherichia coli IAI39 7150090 YP_002408859.1 CDS ECIAI39_2927 NC_011750.1 3034423 3035016 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme; putative non-oxidative hydroxyarylic acid decarboxylase complement(3034423..3035016) Escherichia coli IAI39 7150091 YP_002408860.1 CDS ECIAI39_2928 NC_011750.1 3035163 3035570 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15731069; Product type r : regulator; transcriptional regulator hosA 3035163..3035570 Escherichia coli IAI39 7150092 YP_002408861.1 CDS rpoS NC_011750.1 3035691 3036683 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses; RNA polymerase sigma factor RpoS complement(3035691..3036683) Escherichia coli IAI39 7150093 YP_002408862.1 CDS nlpD NC_011750.1 3036746 3037885 R outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD complement(3036746..3037885) Escherichia coli IAI39 7152710 YP_002408863.1 CDS pcm NC_011750.1 3038025 3038651 R catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase complement(3038025..3038651) Escherichia coli IAI39 7152236 YP_002408864.1 CDS surE NC_011750.1 3038645 3039406 R catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE complement(3038645..3039406) Escherichia coli IAI39 7152352 YP_002408865.1 CDS truD NC_011750.1 3039387 3040436 R catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D complement(3039387..3040436) Escherichia coli IAI39 7152933 YP_002408866.1 CDS ispF NC_011750.1 3040433 3040912 R catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase complement(3040433..3040912) Escherichia coli IAI39 7153042 YP_002408867.1 CDS ispD NC_011750.1 3040912 3041622 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(3040912..3041622) Escherichia coli IAI39 7151855 YP_002408868.1 CDS ftsB NC_011750.1 3041641 3041952 R forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB complement(3041641..3041952) Escherichia coli IAI39 7151853 YP_002408869.1 CDS ygbE NC_011750.1 3042146 3042469 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3042146..3042469) Escherichia coli IAI39 7151434 YP_002408870.1 CDS cysC NC_011750.1 3042519 3043124 R converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase complement(3042519..3043124) Escherichia coli IAI39 7153930 YP_002408871.1 CDS cysN NC_011750.1 3043124 3044551 R may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 complement(3043124..3044551) Escherichia coli IAI39 7151057 YP_002408872.1 CDS cysD NC_011750.1 3044553 3045461 R with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 complement(3044553..3045461) Escherichia coli IAI39 7151066 YP_002408873.1 CDS iap NC_011750.1 3045713 3046750 D catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase isozyme conversion aminopeptidase 3045713..3046750 Escherichia coli IAI39 7151058 YP_002408874.1 CDS ECIAI39_2943 NC_011750.1 3046877 3047029 R Evidence 1b : Function experimentally demonstrated in the studied species; Product type pm : putative membrane component; small toxic peptide complement(3046877..3047029) Escherichia coli IAI39 7151743 YP_002408875.1 CDS cysH NC_011750.1 3047294 3048028 R catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase complement(3047294..3048028) Escherichia coli IAI39 7150094 YP_002408876.1 CDS cysI NC_011750.1 3048102 3049814 R hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta complement(3048102..3049814) Escherichia coli IAI39 7151061 YP_002408877.1 CDS cysJ NC_011750.1 3049814 3051613 R catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha complement(3049814..3051613) Escherichia coli IAI39 7151062 YP_002408878.1 CDS ygcM NC_011750.1 3051929 3052294 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123838; Product type e : enzyme; 6-pyruvoyl tetrahydrobiopterin synthase 3051929..3052294 Escherichia coli IAI39 7151063 YP_002408879.1 CDS ygcN NC_011750.1 3052372 3053643 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 3052372..3053643 Escherichia coli IAI39 7153934 YP_002408880.1 CDS ygcO NC_011750.1 3053634 3053894 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative 4Fe-4S cluster-containing protein 3053634..3053894 Escherichia coli IAI39 7153935 YP_002408881.1 CDS ygcP NC_011750.1 3053911 3054486 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative anti-terminator regulatory protein 3053911..3054486 Escherichia coli IAI39 7153936 YP_002408882.1 CDS ygcQ NC_011750.1 3054633 3055493 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative flavoprotein complement(3054633..3055493) Escherichia coli IAI39 7153937 YP_002408883.1 CDS ygcR NC_011750.1 3055490 3056269 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative flavoprotein complement(3055490..3056269) Escherichia coli IAI39 7153938 YP_002408884.1 CDS ygcS NC_011750.1 3056247 3057584 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(3056247..3057584) Escherichia coli IAI39 7153939 YP_002408885.1 CDS ygcU NC_011750.1 3057678 3059132 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative FAD containing dehydrogenase complement(3057678..3059132) Escherichia coli IAI39 7153940 YP_002408886.1 CDS ygcW NC_011750.1 3059202 3059987 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative deoxygluconate dehydrogenase complement(3059202..3059987) Escherichia coli IAI39 7153941 YP_002408887.1 CDS ECIAI39_2957 NC_011750.1 3060701 3061147 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 complement(3060701..3061147) Escherichia coli IAI39 7154501 YP_002408888.1 CDS ECIAI39_2958 NC_011750.1 3061264 3062787 R Group II intron-encoded reverse transcriptase/maturase complement(3061264..3062787) Escherichia coli IAI39 7150095 YP_002408889.1 CDS ECIAI39_2959 NC_011750.1 3063379 3063861 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 complement(3063379..3063861) Escherichia coli IAI39 7150096 YP_002408890.1 CDS ECIAI39_2960 NC_011750.1 3063858 3064184 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 complement(3063858..3064184) Escherichia coli IAI39 7150097 YP_002408891.1 CDS ygcE NC_011750.1 3065193 3066671 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative kinase 3065193..3066671 Escherichia coli IAI39 7154502 YP_002408892.1 CDS ECIAI39_2963 NC_011750.1 3066836 3067756 D phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least; aminoimidazole riboside kinase 3066836..3067756 Escherichia coli IAI39 7153931 YP_002408893.1 CDS ECIAI39_2964 NC_011750.1 3067924 3069441 D Evidence 2b : Function of strongly homologous gene; Product type m : membrane component; Sucrose porin 3067924..3069441 Escherichia coli IAI39 7150099 YP_002408894.1 CDS ECIAI39_2965 NC_011750.1 3069502 3070872 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; PTS system sucrose-specific EIIBC component 3069502..3070872 Escherichia coli IAI39 7150100 YP_002408895.1 CDS ECIAI39_2966 NC_011750.1 3070872 3072281 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; sucrose-6-phosphate hydrolase 3070872..3072281 Escherichia coli IAI39 7150101 YP_002408896.1 CDS ECIAI39_2967 NC_011750.1 3072307 3073314 D Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Sucrose operon repressor 3072307..3073314 Escherichia coli IAI39 7150102 YP_002408897.1 CDS ygcF NC_011750.1 3073399 3074070 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3073399..3074070) Escherichia coli IAI39 7150103 YP_002408898.1 CDS ECIAI39_2969 NC_011750.1 3074032 3074100 D hypothetical protein 3074032..3074100 Escherichia coli IAI39 7153932 YP_002408899.1 CDS ygcG NC_011750.1 3074364 3075236 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3074364..3075236 Escherichia coli IAI39 7150104 YP_002408900.1 CDS insG NC_011750.1 3075282 3076628 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element complement(3075282..3076628) Escherichia coli IAI39 7153933 YP_002408901.1 CDS ECIAI39_2973 NC_011750.1 3077218 3078120 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3077218..3078120 Escherichia coli IAI39 7154207 YP_002408902.1 CDS uvrD NC_011750.1 3078175 3080337 R unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II complement(3078175..3080337) Escherichia coli IAI39 7150105 YP_002408903.1 CDS yigB NC_011750.1 3080421 3081137 R YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase complement(3080421..3081137) Escherichia coli IAI39 7153116 YP_002408904.1 CDS xerC NC_011750.1 3081137 3082033 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC complement(3081137..3082033) Escherichia coli IAI39 7154206 YP_002408905.1 CDS yigA NC_011750.1 3082030 3082737 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3082030..3082737) Escherichia coli IAI39 7153179 YP_002408906.1 CDS dapF NC_011750.1 3082734 3083558 R involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase complement(3082734..3083558) Escherichia coli IAI39 7154205 YP_002408907.1 CDS yifL NC_011750.1 3083595 3083798 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein complement(3083595..3083798) Escherichia coli IAI39 7151088 YP_002408908.1 CDS ECIAI39_2980 NC_011750.1 3084140 3084694 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3084140..3084694 Escherichia coli IAI39 7154204 YP_002408909.1 CDS ECIAI39_2981 NC_011750.1 3084735 3084950 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3084735..3084950 Escherichia coli IAI39 7150106 YP_002408910.1 CDS ECIAI39_2982 NC_011750.1 3085037 3087094 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3085037..3087094 Escherichia coli IAI39 7150107 YP_002408911.1 CDS cyaY NC_011750.1 3087142 3087462 D defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 3087142..3087462 Escherichia coli IAI39 7150108 YP_002408912.1 CDS cyaA NC_011750.1 3087502 3090048 R catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase complement(3087502..3090048) Escherichia coli IAI39 7151039 YP_002408913.1 CDS hemC NC_011750.1 3090435 3091376 D transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 3090435..3091376 Escherichia coli IAI39 7151038 YP_002408914.1 CDS hemD NC_011750.1 3091373 3092113 D catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 3091373..3092113 Escherichia coli IAI39 7151626 YP_002408915.1 CDS hemX NC_011750.1 3092135 3093316 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 89098348, 92358234, 3054815, 3062586, 9298646; Product type pe : putative enzyme; putative uroporphyrinogen III C-methyltransferase 3092135..3093316 Escherichia coli IAI39 7151627 YP_002408916.1 CDS hemY NC_011750.1 3093319 3094515 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 89041586; Product type pe : putative enzyme; putative protoheme IX biogenesis protein 3093319..3094515 Escherichia coli IAI39 7151634 YP_002408917.1 CDS aslA NC_011750.1 3095201 3096856 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16766528, 92358234, 15477040; Product type e : enzyme; arylsulfatase-like enzyme 3095201..3096856 Escherichia coli IAI39 7152793 YP_002408918.1 CDS aslB NC_011750.1 3097014 3098249 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11222759, 2180918, 12419807, 14749327; Product type pr : putative regulator; regulator of arylsulfatase activity complement(3097014..3098249) Escherichia coli IAI39 7150799 YP_002408919.1 CDS yifK NC_011750.1 3098935 3100320 R uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; putative transport protein YifK complement(3098935..3100320) Escherichia coli IAI39 7150602 YP_002408920.1 CDS rffM NC_011750.1 3100511 3101251 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88086874, 90337949, 92112804; Product type e : enzyme; putative UDP-N-acetyl-D-mannosaminuronic acid transferase complement(3100511..3101251) Escherichia coli IAI39 7154203 YP_002408921.1 CDS wzyE NC_011750.1 3101254 3102606 R enterobacterial common antigen polymerase; putative common antigen polymerase complement(3101254..3102606) Escherichia coli IAI39 7152610 YP_002408922.1 CDS rffT NC_011750.1 3102603 3103682 R catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase complement(3102603..3103682) Escherichia coli IAI39 7153169 YP_002408923.1 CDS wzxE NC_011750.1 3103679 3104929 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12621029, 20044778; Product type t : transporter; O-antigen translocase complement(3103679..3104929) Escherichia coli IAI39 7152611 YP_002408924.1 CDS rffA NC_011750.1 3104931 3106061 R catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase complement(3104931..3106061) Escherichia coli IAI39 7153167 YP_002408925.1 CDS rffC NC_011750.1 3106066 3106740 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90212314, 90337949, 92112804, 8366065; Product type e : enzyme; TDP-fucosamine acetyltransferase complement(3106066..3106740) Escherichia coli IAI39 7152604 YP_002408926.1 CDS rffH NC_011750.1 3106718 3107599 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94292435, 96032389; Product type e : enzyme; glucose-1-phosphate thymidylyltransferase complement(3106718..3107599) Escherichia coli IAI39 7152605 YP_002408927.1 CDS rffG NC_011750.1 3107618 3108685 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88086930, 90212314, 90337949, 92112804, 92174908, 94018634, 94042873, 7559340; Product type e : enzyme; dTDP-glucose 4,6-dehydratase complement(3107618..3108685) Escherichia coli IAI39 7152609 YP_002408928.1 CDS wecC NC_011750.1 3108685 3109947 R catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase complement(3108685..3109947) Escherichia coli IAI39 7152608 YP_002408929.1 CDS rffE NC_011750.1 3109944 3111074 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90212314, 90337949, 92112804, 94042873, 11106477, 7559340, 8170390, 8226648; Product type e : enzyme; UDP-N-acetyl glucosamine-2-epimerase complement(3109944..3111074) Escherichia coli IAI39 7152606 YP_002408930.1 CDS wzzE NC_011750.1 3111130 3112176 R Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE complement(3111130..3112176) Escherichia coli IAI39 7152607 YP_002408931.1 CDS rfe NC_011750.1 3112188 3113291 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92114763, 94245613, 94292435, 10629198, 11024259, 11700352, 11832520, 1722555, 1730666; Product type e : enzyme; UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase complement(3112188..3113291) Escherichia coli IAI39 7153170 YP_002408932.1 CDS ECIAI39_3004 NC_011750.1 3113303 3113521 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3113303..3113521) Escherichia coli IAI39 7152603 YP_002408933.1 CDS rho NC_011750.1 3113531 3114790 R An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho complement(3113531..3114790) Escherichia coli IAI39 7150109 YP_002408934.1 CDS rhoL NC_011750.1 3114875 3114976 R Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; putative rho operon leader peptide complement(3114875..3114976) Escherichia coli IAI39 7152620 YP_002408935.1 CDS trxA NC_011750.1 3115117 3115446 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202710, 91154193, 92250497, 99175138, 10489448, 1094461, 10947986, 1561103, 2181145, 2193685, 3891733, 4616096, 4883076, 6098320, 6099324, 7812718, 8098620, 8253691; Product type c : carrier; thioredoxin complement(3115117..3115446) Escherichia coli IAI39 7152621 YP_002408936.1 CDS rhlB NC_011750.1 3115577 3116842 D enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB 3115577..3116842 Escherichia coli IAI39 7153043 YP_002408937.1 CDS gpp NC_011750.1 3116978 3118462 D catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase 3116978..3118462 Escherichia coli IAI39 7152618 YP_002408938.1 CDS rep NC_011750.1 3118509 3120530 R single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep complement(3118509..3120530) Escherichia coli IAI39 7151580 YP_002408939.1 CDS ECIAI39_3010 NC_011750.1 3120706 3121197 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3120706..3121197 Escherichia coli IAI39 7152600 YP_002408940.1 CDS ppiC NC_011750.1 3121350 3121631 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94215709, 7878732, 7925971, 8163020; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase C 3121350..3121631 Escherichia coli IAI39 7150110 YP_002408941.1 CDS ilvC NC_011750.1 3121677 3123152 R catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase complement(3121677..3123152) Escherichia coli IAI39 7152462 YP_002408942.1 CDS ilvY NC_011750.1 3123218 3124192 D participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 3123218..3124192 Escherichia coli IAI39 7151765 YP_002408943.1 CDS ilvA NC_011750.1 3124189 3125733 R threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase complement(3124189..3125733) Escherichia coli IAI39 7151774 YP_002408944.1 CDS ilvD NC_011750.1 3125736 3127586 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(3125736..3127586) Escherichia coli IAI39 7151763 YP_002408945.1 CDS ilvE NC_011750.1 3127651 3128580 R catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase complement(3127651..3128580) Escherichia coli IAI39 7151766 YP_002408946.1 CDS ilvM NC_011750.1 3128600 3128863 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92332418, 92380929, 1569580, 3550695, 3897211; Product type e : enzyme; acetolactate synthase 2 regulatory subunit complement(3128600..3128863) Escherichia coli IAI39 7151767 YP_002408947.1 CDS ilvG NC_011750.1 3128860 3130506 R catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit complement(3128860..3130506) Escherichia coli IAI39 7151772 YP_002408948.1 CDS ilvL NC_011750.1 3130646 3130744 R Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; ilvG operon leader peptide complement(3130646..3130744) Escherichia coli IAI39 7151768 YP_002408949.1 CDS yifB NC_011750.1 3131067 3132617 D among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function; putative ATP-dependent protease 3131067..3132617 Escherichia coli IAI39 7151771 YP_002408950.1 CDS yifE NC_011750.1 3132642 3132980 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3132642..3132980) Escherichia coli IAI39 7154201 YP_002408951.1 CDS hdfR NC_011750.1 3133099 3133938 D Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR 3133099..3133938 Escherichia coli IAI39 7154202 YP_002408952.1 CDS murI NC_011750.1 3139670 3140527 R converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase complement(3139670..3140527) Escherichia coli IAI39 7149776 YP_002408953.1 CDS btuB NC_011750.1 3140472 3142316 R involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter complement(3140472..3142316) Escherichia coli IAI39 7152152 YP_002408954.1 CDS trmA NC_011750.1 3142685 3143785 D catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 3142685..3143785 Escherichia coli IAI39 7150541 YP_002408955.1 CDS yijD NC_011750.1 3143825 3144184 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3143825..3144184) Escherichia coli IAI39 7153025 YP_002408956.1 CDS fabR NC_011750.1 3144184 3144888 R negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR complement(3144184..3144888) Escherichia coli IAI39 7154246 YP_002408957.1 CDS sthA NC_011750.1 3145166 3146566 D catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 3145166..3146566 Escherichia coli IAI39 7151270 YP_002408958.1 CDS oxyR NC_011750.1 3146549 3147466 R Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR complement(3146549..3147466) Escherichia coli IAI39 7152916 YP_002408959.1 CDS argH NC_011750.1 3147732 3149105 R catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase complement(3147732..3149105) Escherichia coli IAI39 7152316 YP_002408960.1 CDS argB NC_011750.1 3149166 3149939 R catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase complement(3149166..3149939) Escherichia coli IAI39 7150766 YP_002408961.1 CDS argC NC_011750.1 3149950 3150954 R catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase complement(3149950..3150954) Escherichia coli IAI39 7150761 YP_002408962.1 CDS argE NC_011750.1 3151108 3152259 D catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase 3151108..3152259 Escherichia coli IAI39 7150762 YP_002408963.1 CDS ppc NC_011750.1 3152561 3155212 D catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 3152561..3155212 Escherichia coli IAI39 7150764 YP_002408964.1 CDS yijP NC_011750.1 3155395 3157128 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10456927; Product type pm : putative membrane component; hypothetical protein 3155395..3157128 Escherichia coli IAI39 7152453 YP_002408965.1 CDS yijO NC_011750.1 3157277 3158128 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 3157277..3158128 Escherichia coli IAI39 7154250 YP_002408966.1 CDS frwD NC_011750.1 3158115 3158456 R FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; putative fructose-like phosphotransferase EIIB subunit 3 complement(3158115..3158456) Escherichia coli IAI39 7154249 YP_002408967.1 CDS pflC NC_011750.1 3158458 3159336 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95291446, 14673546, 7773398; Product type e : enzyme; pyruvate formate lyase II activase complement(3158458..3159336) Escherichia coli IAI39 7151429 YP_002408968.1 CDS pflD NC_011750.1 3159302 3161599 R involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; putative formate acetyltransferase 2 complement(3159302..3161599) Escherichia coli IAI39 7152374 YP_002408969.1 CDS frwB NC_011750.1 3161650 3161970 R FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; putative PTS system fructose-like transporter subunit EIIB complement(3161650..3161970) Escherichia coli IAI39 7152375 YP_002408970.1 CDS frwC NC_011750.1 3161985 3163064 R FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site; putative fructose-like permease EIIC subunit 2 complement(3161985..3163064) Escherichia coli IAI39 7151427 YP_002408971.1 CDS ptsA NC_011750.1 3163373 3165874 D Evidence 2b : Function of strongly homologous gene; PubMedId : 95291446, 7773398; Product type t : transporter; putative PTS system Hpr component/enzyme I component/subunit IIA 3163373..3165874 Escherichia coli IAI39 7151428 YP_002408972.1 CDS fsaB NC_011750.1 3165886 3166548 D similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 3165886..3166548 Escherichia coli IAI39 7152517 YP_002408973.1 CDS gldA NC_011750.1 3166559 3167662 D forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 3166559..3167662 Escherichia coli IAI39 7151431 YP_002408974.1 CDS yijF NC_011750.1 3167937 3168554 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3167937..3168554 Escherichia coli IAI39 7151511 YP_002408975.1 CDS yijE NC_011750.1 3168581 3169486 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease complement(3168581..3169486) Escherichia coli IAI39 7154248 YP_002408976.1 CDS katG NC_011750.1 3169580 3171760 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90292022, 94209230, 3045098; Product type e : enzyme; catalase/hydroperoxidase HPI(I) complement(3169580..3171760) Escherichia coli IAI39 7154247 YP_002408977.1 CDS metF NC_011750.1 3172088 3172978 R MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase complement(3172088..3172978) Escherichia coli IAI39 7151872 YP_002408978.1 CDS ECIAI39_3048 NC_011750.1 3173360 3174919 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphoesterase complement(3173360..3174919) Escherichia coli IAI39 7152054 YP_002408979.1 CDS ECIAI39_3049 NC_011750.1 3175046 3176173 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3175046..3176173 Escherichia coli IAI39 7150111 YP_002408980.1 CDS ECIAI39_3050 NC_011750.1 3175466 3175627 R hypothetical protein complement(3175466..3175627) Escherichia coli IAI39 7150112 YP_002408981.1 CDS ECIAI39_3051 NC_011750.1 3176403 3177956 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 5'-nucleotidase 3176403..3177956 Escherichia coli IAI39 7150113 YP_002408982.1 CDS ECIAI39_3052 NC_011750.1 3177991 3179616 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 5'-nucleotidase/2',3'-cyclic phosphodiesterase 3177991..3179616 Escherichia coli IAI39 7150114 YP_002408983.1 CDS tsx NC_011750.1 3179695 3180555 D Evidence 1b : Function experimentally demonstrated in the studied species; Product type m : membrane component; nucleoside channel phage T6/colicin K receptor 3179695..3180555 Escherichia coli IAI39 7150115 YP_002408984.1 CDS metL NC_011750.1 3180772 3183204 R multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II complement(3180772..3183204) Escherichia coli IAI39 7153050 YP_002408985.1 CDS metB NC_011750.1 3183207 3184367 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87326410, 90148970, 3307782, 6361020, 9843488; Product type e : enzyme; cystathionine gamma-synthase, PLP-dependent complement(3183207..3184367) Escherichia coli IAI39 7152060 YP_002408986.1 CDS metJ NC_011750.1 3184506 3184961 D when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ 3184506..3184961 Escherichia coli IAI39 7152051 YP_002408987.1 CDS yiiX NC_011750.1 3185021 3185629 D member of the NlpC/P60 superfamily of peptidases; putative peptidoglycan peptidase 3185021..3185629 Escherichia coli IAI39 7152058 YP_002408988.1 CDS rpmE NC_011750.1 3185690 3185902 R RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 complement(3185690..3185902) Escherichia coli IAI39 7154245 YP_002408989.1 CDS priA NC_011750.1 3186105 3188303 D binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 3186105..3188303 Escherichia coli IAI39 7152698 YP_002408990.1 CDS cytR NC_011750.1 3188459 3189484 D negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR 3188459..3189484 Escherichia coli IAI39 7152476 YP_002408991.1 CDS ftsN NC_011750.1 3189576 3190535 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9282742, 93285993, 8509333; Product type cp : cell process; essential cell division protein FtsN 3189576..3190535 Escherichia coli IAI39 7151073 YP_002408992.1 CDS hslV NC_011750.1 3190627 3191157 D heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 3190627..3191157 Escherichia coli IAI39 7151440 YP_002408993.1 CDS hslU NC_011750.1 3191167 3192498 D heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 3191167..3192498 Escherichia coli IAI39 7151684 YP_002408994.1 CDS menA NC_011750.1 3192565 3193491 D catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 3192565..3193491 Escherichia coli IAI39 7151683 YP_002408995.1 CDS rraA NC_011750.1 3193584 3194069 D regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 3193584..3194069 Escherichia coli IAI39 7152043 YP_002408996.1 CDS ECIAI39_3066 NC_011750.1 3194117 3194803 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3194117..3194803 Escherichia coli IAI39 7152734 YP_002408997.1 CDS ECIAI39_3067 NC_011750.1 3194836 3195552 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3194836..3195552 Escherichia coli IAI39 7150116 YP_002408998.1 CDS yiiU NC_011750.1 3195591 3195836 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3195591..3195836) Escherichia coli IAI39 7150117 YP_002408999.1 CDS glpF NC_011750.1 3196261 3197106 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12629974, 12948772, 14646142, 15004242, 90094250, 92210584, 11039922, 11101882, 11226336, 11964478, 1372899, 2544860, 6998951; Product type t : transporter; glycerol facilitator 3196261..3197106 Escherichia coli IAI39 7154244 YP_002409000.1 CDS glpK NC_011750.1 3197129 3198637 D Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 3197129..3198637 Escherichia coli IAI39 7151541 YP_002409001.1 CDS glpX NC_011750.1 3198772 3199782 D type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 3198772..3199782 Escherichia coli IAI39 7151543 YP_002409002.1 CDS fpr NC_011750.1 3199879 3200625 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93194782, 94092163, 95050480, 95362685, 1400248, 2834327, 7961651, 8449868, 9149148; Product type e : enzyme; ferredoxin-NADP reductase 3199879..3200625 Escherichia coli IAI39 7151547 YP_002409003.1 CDS yiiT NC_011750.1 3200630 3201058 R with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD complement(3200630..3201058) Escherichia coli IAI39 7151406 YP_002409004.1 CDS yiiS NC_011750.1 3201085 3201384 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3201085..3201384) Escherichia coli IAI39 7154243 YP_002409005.1 CDS yiiR NC_011750.1 3201596 3202036 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3201596..3202036) Escherichia coli IAI39 7154242 YP_002409006.1 CDS yiiQ NC_011750.1 3202137 3202736 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3202137..3202736 Escherichia coli IAI39 7154241 YP_002409007.1 CDS tpiA NC_011750.1 3202844 3203611 D Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 3202844..3203611 Escherichia coli IAI39 7154240 YP_002409008.1 CDS cdh NC_011750.1 3203666 3204421 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86008270, 2995360, 3158524; Product type e : enzyme; CDP-diacylglycerol pyrophosphatase complement(3203666..3204421) Escherichia coli IAI39 7153013 YP_002409009.1 CDS sbp NC_011750.1 3204528 3205517 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91161616, 2002055, 3158524, 8774726, 9298646; Product type t : transporter; sulfate transporter subunit complement(3204528..3205517) Escherichia coli IAI39 7150921 YP_002409010.1 CDS pfkA NC_011750.1 3205837 3206799 R catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase complement(3205837..3206799) Escherichia coli IAI39 7152809 YP_002409011.1 CDS fieF NC_011750.1 3206980 3207882 R member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F complement(3206980..3207882) Escherichia coli IAI39 7152370 YP_002409012.1 CDS cpxP NC_011750.1 3208031 3208531 R repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; periplasmic repressor CpxP complement(3208031..3208531) Escherichia coli IAI39 7151325 YP_002409013.1 CDS cpxR NC_011750.1 3208681 3209379 D response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR 3208681..3209379 Escherichia coli IAI39 7150990 YP_002409014.1 CDS cpxA NC_011750.1 3209376 3210749 D part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein 3209376..3210749 Escherichia coli IAI39 7150991 YP_002409015.1 CDS yiiM NC_011750.1 3210854 3211528 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3210854..3211528) Escherichia coli IAI39 7150989 YP_002409016.1 CDS kdgT NC_011750.1 3211677 3212660 R transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease complement(3211677..3212660) Escherichia coli IAI39 7154239 YP_002409017.1 CDS sodA NC_011750.1 3212920 3213540 R SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase complement(3212920..3213540) Escherichia coli IAI39 7151879 YP_002409018.1 CDS rhaT NC_011750.1 3213825 3214859 D transports L-rhamnose and L-lyxose into the cell; rhamnose-proton symporter 3213825..3214859 Escherichia coli IAI39 7152870 YP_002409019.1 CDS rhaR NC_011750.1 3214856 3215794 R activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR complement(3214856..3215794) Escherichia coli IAI39 7152617 YP_002409020.1 CDS rhaS NC_011750.1 3215778 3216614 R activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS complement(3215778..3216614) Escherichia coli IAI39 7152615 YP_002409021.1 CDS rhaB NC_011750.1 3216902 3218371 D catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase 3216902..3218371 Escherichia coli IAI39 7152616 YP_002409022.1 CDS rhaA NC_011750.1 3218368 3219627 D catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase 3218368..3219627 Escherichia coli IAI39 7152613 YP_002409023.1 CDS ECIAI39_3093 NC_011750.1 3219693 3220223 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 3219693..3220223 Escherichia coli IAI39 7152612 YP_002409024.1 CDS ECIAI39_3094 NC_011750.1 3220328 3221050 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 3220328..3221050 Escherichia coli IAI39 7150118 YP_002409025.1 CDS rhaD NC_011750.1 3221145 3221969 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90128204, 93374854, 8396120; Product type e : enzyme; rhamnulose-1-phosphate aldolase 3221145..3221969 Escherichia coli IAI39 7150119 YP_002409026.1 CDS yiiL NC_011750.1 3221979 3222293 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15060078; Product type e : enzyme; L-rhamnose mutarotase 3221979..3222293 Escherichia coli IAI39 7152614 YP_002409027.1 CDS ECIAI39_3097 NC_011750.1 3222334 3223728 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative glycoporin complement(3222334..3223728) Escherichia coli IAI39 7154238 YP_002409028.1 CDS frvA NC_011750.1 3224205 3224651 D with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system; putative fructose-like phosphotransferase system subunit EIIA 3224205..3224651 Escherichia coli IAI39 7150120 YP_002409029.1 CDS frvB NC_011750.1 3224662 3226113 D Evidence 2b : Function of strongly homologous gene; PubMedId : 94290319; Product type t : transporter; putative PTS system transporter subunits IIBC 3224662..3226113 Escherichia coli IAI39 7151423 YP_002409030.1 CDS frvX NC_011750.1 3226103 3227173 D with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars; putative fructose-specific phosphotransferase system protein FrvX 3226103..3227173 Escherichia coli IAI39 7151424 YP_002409031.1 CDS frvR NC_011750.1 3227173 3228921 D putative repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system; putative frv operon regulatory protein 3227173..3228921 Escherichia coli IAI39 7151426 YP_002409032.1 CDS yiiG NC_011750.1 3228971 3230026 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3228971..3230026) Escherichia coli IAI39 7151425 YP_002409033.1 CDS fdhD NC_011750.1 3230179 3231012 R involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein complement(3230179..3231012) Escherichia coli IAI39 7154237 YP_002409034.1 CDS fdoG NC_011750.1 3231206 3234256 D Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-O, large subunit 3231206..3234256 Escherichia coli IAI39 7151283 YP_002409035.1 CDS fdoH NC_011750.1 3234269 3235171 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91317715, 8522521, 9852007; Product type c : carrier; formate dehydrogenase-O, Fe-S subunit 3234269..3235171 Escherichia coli IAI39 7151289 YP_002409036.1 CDS fdoI NC_011750.1 3235168 3235803 D cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma 3235168..3235803 Escherichia coli IAI39 7151290 YP_002409037.1 CDS fdhE NC_011750.1 3235800 3236729 D required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 3235800..3236729 Escherichia coli IAI39 7151291 YP_002409038.1 CDS yiiF NC_011750.1 3237058 3237300 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3237058..3237300) Escherichia coli IAI39 7151284 YP_002409039.1 CDS yiiE NC_011750.1 3237520 3237738 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator complement(3237520..3237738) Escherichia coli IAI39 7154236 YP_002409040.1 CDS ECIAI39_3111 NC_011750.1 3238434 3240287 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3238434..3240287) Escherichia coli IAI39 7154235 YP_002409041.1 CDS yiiD NC_011750.1 3240664 3241653 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase complement(3240664..3241653) Escherichia coli IAI39 7150121 YP_002409042.1 CDS dtd NC_011750.1 3241650 3242087 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(3241650..3242087) Escherichia coli IAI39 7154234 YP_002409043.1 CDS rbn NC_011750.1 3242084 3242956 R RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN complement(3242084..3242956) Escherichia coli IAI39 7151185 YP_002409044.1 CDS yihX NC_011750.1 3242950 3243549 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; phosphatase complement(3242950..3243549) Escherichia coli IAI39 7152570 YP_002409045.1 CDS yihW NC_011750.1 3243648 3244433 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3243648..3244433) Escherichia coli IAI39 7154233 YP_002409046.1 CDS yihV NC_011750.1 3244467 3245363 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar kinase complement(3244467..3245363) Escherichia coli IAI39 7154232 YP_002409047.1 CDS yihU NC_011750.1 3245531 3246427 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 3245531..3246427 Escherichia coli IAI39 7154231 YP_002409048.1 CDS yihT NC_011750.1 3246451 3247329 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldolase 3246451..3247329 Escherichia coli IAI39 7154230 YP_002409049.1 CDS yihS NC_011750.1 3247345 3248529 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative glucosamine isomerase 3247345..3248529 Escherichia coli IAI39 7154229 YP_002409050.1 CDS yihR NC_011750.1 3248588 3249499 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative aldose-1-epimerase 3248588..3249499 Escherichia coli IAI39 7154228 YP_002409051.1 CDS yihQ NC_011750.1 3249697 3251733 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15294295; Product type e : enzyme; alpha-glucosidase 3249697..3251733 Escherichia coli IAI39 7154227 YP_002409052.1 CDS yihP NC_011750.1 3251746 3253164 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3251746..3253164 Escherichia coli IAI39 7154226 YP_002409053.1 CDS yihO NC_011750.1 3253207 3254610 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3253207..3254610 Escherichia coli IAI39 7154225 YP_002409054.1 CDS ompL NC_011750.1 3254677 3255369 D porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown; outer membrane porin L 3254677..3255369 Escherichia coli IAI39 7154224 YP_002409055.1 CDS yihN NC_011750.1 3255461 3256726 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(3255461..3256726) Escherichia coli IAI39 7152294 YP_002409056.1 CDS yihM NC_011750.1 3256828 3257808 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar phosphate isomerase complement(3256828..3257808) Escherichia coli IAI39 7154223 YP_002409057.1 CDS yihL NC_011750.1 3257816 3258526 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3257816..3258526) Escherichia coli IAI39 7154222 YP_002409058.1 CDS insG NC_011750.1 3258783 3260129 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element 3258783..3260129 Escherichia coli IAI39 7154221 YP_002409059.1 CDS bipA NC_011750.1 3260181 3262004 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9642082, 7783627, 9298646, 9622352; Product type f : factor; GTP-binding protein complement(3260181..3262004) Escherichia coli IAI39 7151813 YP_002409060.1 CDS glnA NC_011750.1 3262377 3263786 D forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase 3262377..3263786 Escherichia coli IAI39 7150868 YP_002409061.1 CDS glnL NC_011750.1 3263960 3265009 D sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) 3263960..3265009 Escherichia coli IAI39 7151523 YP_002409062.1 CDS glnG NC_011750.1 3265021 3266430 D response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) 3265021..3266430 Escherichia coli IAI39 7151530 YP_002409063.1 CDS hemN NC_011750.1 3266880 3268253 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(3266880..3268253) Escherichia coli IAI39 7151527 YP_002409064.1 CDS yihI NC_011750.1 3268442 3268951 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3268442..3268951) Escherichia coli IAI39 7151633 YP_002409065.1 CDS engB NC_011750.1 3269569 3270165 D binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 3269569..3270165 Escherichia coli IAI39 7151023 YP_002409066.1 CDS polA NC_011750.1 3270547 3273333 R has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I complement(3270547..3273333) Escherichia coli IAI39 7152886 YP_002409067.1 CDS yihG NC_011750.1 3273697 3274629 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyltransferase 3273697..3274629 Escherichia coli IAI39 7152439 YP_002409068.1 CDS yihF NC_011750.1 3274670 3276100 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3274670..3276100) Escherichia coli IAI39 7154219 YP_002409069.1 CDS dsbA NC_011750.1 3276255 3276881 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12498799, 93264419, 94016574, 94206930, 99298180, 10210188, 1429594, 1740115, 1934062, 8413591, 8494885, 8521518, 9194175, 9298646, 9300489, 9572841, 9600841, 9655827; Product type e : enzyme; periplasmic protein disulfide isomerase I complement(3276255..3276881) Escherichia coli IAI39 7154218 YP_002409070.1 CDS yihE NC_011750.1 3276898 3277884 R catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase complement(3276898..3277884) Escherichia coli IAI39 7151172 YP_002409071.1 CDS yihD NC_011750.1 3277961 3278230 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3277961..3278230) Escherichia coli IAI39 7154217 YP_002409072.1 CDS mobA NC_011750.1 3278300 3278884 D in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA 3278300..3278884 Escherichia coli IAI39 7154216 YP_002409073.1 CDS mobB NC_011750.1 3278881 3279393 D in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; molybdopterin-guanine dinucleotide biosynthesis protein B 3278881..3279393 Escherichia coli IAI39 7152100 YP_002409074.1 CDS hemG NC_011750.1 3284967 3285512 R catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase complement(3284967..3285512) Escherichia coli IAI39 7149775 YP_002409075.1 CDS trkH NC_011750.1 3285524 3286975 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100357, 2243799, 7896723; Product type t : transporter; potassium transporter complement(3285524..3286975) Escherichia coli IAI39 7151630 YP_002409076.1 CDS yigZ NC_011750.1 3287014 3287628 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15103642; Product type pf : putative factor; hypothetical protein complement(3287014..3287628) Escherichia coli IAI39 7153024 YP_002409077.1 CDS pepQ NC_011750.1 3287628 3288959 R catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase complement(3287628..3288959) Escherichia coli IAI39 7154214 YP_002409078.1 CDS fadB NC_011750.1 3289149 3291338 D includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha 3289149..3291338 Escherichia coli IAI39 7152367 YP_002409079.1 CDS fadA NC_011750.1 3291348 3292511 D FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase 3291348..3292511 Escherichia coli IAI39 7151273 YP_002409080.1 CDS ECIAI39_3151 NC_011750.1 3292621 3293343 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group complement(3292621..3293343) Escherichia coli IAI39 7151272 YP_002409081.1 CDS ECIAI39_3152 NC_011750.1 3293448 3293978 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 complement(3293448..3293978) Escherichia coli IAI39 7150122 YP_002409082.1 CDS fre NC_011750.1 3294138 3294839 R NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase complement(3294138..3294839) Escherichia coli IAI39 7150123 YP_002409083.1 CDS ubiD NC_011750.1 3294885 3296378 R catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate decarboxylase complement(3294885..3296378) Escherichia coli IAI39 7151412 YP_002409084.1 CDS rfaH NC_011750.1 3296545 3297033 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92011415, 92250420, 92261317, 1584020, 12007406; Product type r : regulator; transcriptional activator RfaH 3296545..3297033 Escherichia coli IAI39 7153071 YP_002409085.1 CDS tatD NC_011750.1 3297030 3297812 R magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD complement(3297030..3297812) Escherichia coli IAI39 7152602 YP_002409086.1 CDS tatC NC_011750.1 3297854 3298630 R with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC complement(3297854..3298630) Escherichia coli IAI39 7152946 YP_002409087.1 CDS tatB NC_011750.1 3298633 3299148 R mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase complement(3298633..3299148) Escherichia coli IAI39 7152945 YP_002409088.1 CDS tatA NC_011750.1 3299152 3299421 R TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A complement(3299152..3299421) Escherichia coli IAI39 7152944 YP_002409089.1 CDS ubiB NC_011750.1 3299500 3301140 R an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; putative ubiquinone biosynthesis protein UbiB complement(3299500..3301140) Escherichia coli IAI39 7152943 YP_002409090.1 CDS yigP NC_011750.1 3301137 3301742 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3301137..3301742) Escherichia coli IAI39 7153069 YP_002409091.1 CDS ubiE NC_011750.1 3301756 3302511 R Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase complement(3301756..3302511) Escherichia coli IAI39 7154213 YP_002409092.1 CDS rmuC NC_011750.1 3302606 3304033 R YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC complement(3302606..3304033) Escherichia coli IAI39 7153072 YP_002409093.1 CDS ECIAI39_3164 NC_011750.1 3304163 3305017 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3304163..3305017 Escherichia coli IAI39 7152650 YP_002409094.1 CDS ECIAI39_3165 NC_011750.1 3305041 3306045 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; acidic carbohydrate kinase 3305041..3306045 Escherichia coli IAI39 7150124 YP_002409095.1 CDS ECIAI39_3168 NC_011750.1 3306689 3307663 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative periplasmic binding protein 3306689..3307663 Escherichia coli IAI39 7150127 YP_002409096.1 CDS ECIAI39_3169 NC_011750.1 3307677 3308186 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease subunit 3307677..3308186 Escherichia coli IAI39 7150128 YP_002409097.1 CDS ECIAI39_3170 NC_011750.1 3308199 3309689 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3308199..3309689 Escherichia coli IAI39 7150129 YP_002409098.1 CDS udp NC_011750.1 3309723 3310493 R catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase complement(3309723..3310493) Escherichia coli IAI39 7150130 YP_002409099.1 CDS ysgA NC_011750.1 3310683 3311561 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12676709; Product type pe : putative enzyme; putative hydrolase 3310683..3311561 Escherichia coli IAI39 7153079 YP_002409100.1 CDS ECIAI39_3173 NC_011750.1 3311954 3313138 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3311954..3313138 Escherichia coli IAI39 7154568 YP_002409101.1 CDS ECIAI39_3174 NC_011750.1 3313020 3313910 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 complement(3313020..3313910) Escherichia coli IAI39 7150131 YP_002409102.1 CDS ECIAI39_3175 NC_011750.1 3313907 3314233 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 complement(3313907..3314233) Escherichia coli IAI39 7150132 YP_002409103.1 CDS insD NC_011750.1 3314366 3315271 R IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD complement(3314366..3315271) Escherichia coli IAI39 7150133 YP_002409104.1 CDS insC NC_011750.1 3315229 3315639 R IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein complement(3315229..3315639) Escherichia coli IAI39 7151806 YP_002409105.1 CDS ECIAI39_3178 NC_011750.1 3315551 3315643 D hypothetical protein 3315551..3315643 Escherichia coli IAI39 7151803 YP_002409106.1 CDS ECIAI39_3179 NC_011750.1 3315711 3315986 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3315711..3315986 Escherichia coli IAI39 7150134 YP_002409107.1 CDS metE NC_011750.1 3316155 3318416 R catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase complement(3316155..3318416) Escherichia coli IAI39 7150135 YP_002409108.1 CDS metR NC_011750.1 3318534 3319487 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90384950, 96303520, 2205852, 2643109; Product type r : regulator; DNA-binding transcriptional activator, homocysteine-binding 3318534..3319487 Escherichia coli IAI39 7152053 YP_002409109.1 CDS yigM NC_011750.1 3319375 3320274 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3319375..3320274) Escherichia coli IAI39 7152063 YP_002409110.1 CDS yigL NC_011750.1 3320350 3321150 R purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; putative sugar phosphatase complement(3320350..3321150) Escherichia coli IAI39 7154212 YP_002409111.1 CDS pldB NC_011750.1 3321158 3322180 R lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 complement(3321158..3322180) Escherichia coli IAI39 7154211 YP_002409112.1 CDS rhtB NC_011750.1 3322291 3322911 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99313167, 10386596; Product type t : transporter; homoserine/homoserine lactone efflux protein 3322291..3322911 Escherichia coli IAI39 7152426 YP_002409113.1 CDS rhtC NC_011750.1 3322972 3323592 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99313167, 10386596, 3027506; Product type t : transporter; threonine efflux system complement(3322972..3323592) Escherichia coli IAI39 7152623 YP_002409114.1 CDS recQ NC_011750.1 3323656 3325485 R functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ complement(3323656..3325485) Escherichia coli IAI39 7152624 YP_002409115.1 CDS pldA NC_011750.1 3325610 3326479 R catalyzes the hydrolysis of phosphatidylcholine; phospholipase A complement(3325610..3326479) Escherichia coli IAI39 7152596 YP_002409116.1 CDS yigI NC_011750.1 3326644 3327111 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3326644..3327111 Escherichia coli IAI39 7152425 YP_002409117.1 CDS rarD NC_011750.1 3327163 3328053 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative chloramphenicol resistance permease 3327163..3328053 Escherichia coli IAI39 7154210 YP_002409118.1 CDS yigF NC_011750.1 3328542 3328922 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9868784; Product type pm : putative membrane component; hypothetical protein 3328542..3328922 Escherichia coli IAI39 7152566 YP_002409119.1 CDS ECIAI39_3192 NC_011750.1 3328965 3329168 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3328965..3329168) Escherichia coli IAI39 7154209 YP_002409120.1 CDS ECIAI39_3193 NC_011750.1 3329292 3330146 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3329292..3330146 Escherichia coli IAI39 7150136 YP_002409121.1 CDS ECIAI39_3194 NC_011750.1 3330143 3330640 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3330143..3330640 Escherichia coli IAI39 7150137 YP_002409122.1 CDS corA NC_011750.1 3330676 3331626 R responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA complement(3330676..3331626) Escherichia coli IAI39 7150138 YP_002409123.1 CDS insG NC_011750.1 3332345 3333691 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element complement(3332345..3333691) Escherichia coli IAI39 7154208 YP_002409124.1 CDS eno NC_011750.1 3333799 3335097 R enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase complement(3333799..3335097) Escherichia coli IAI39 7151814 YP_002409125.1 CDS pyrG NC_011750.1 3335184 3336821 R CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase complement(3335184..3336821) Escherichia coli IAI39 7151221 YP_002409126.1 CDS mazG NC_011750.1 3337049 3337840 R functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase complement(3337049..3337840) Escherichia coli IAI39 7152553 YP_002409127.1 CDS chpA NC_011750.1 3337912 3338247 R MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA complement(3337912..3338247) Escherichia coli IAI39 7152018 YP_002409128.1 CDS chpR NC_011750.1 3338247 3338495 R part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE complement(3338247..3338495) Escherichia coli IAI39 7150940 YP_002409129.1 CDS relA NC_011750.1 3338573 3340807 R (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase complement(3338573..3340807) Escherichia coli IAI39 7150942 YP_002409130.1 CDS rumA NC_011750.1 3340855 3342156 R in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase complement(3340855..3342156) Escherichia coli IAI39 7152599 YP_002409131.1 CDS ECIAI39_3206 NC_011750.1 3343456 3344178 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group complement(3343456..3344178) Escherichia coli IAI39 7150836 YP_002409132.1 CDS ECIAI39_3207 NC_011750.1 3344283 3344813 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 complement(3344283..3344813) Escherichia coli IAI39 7150139 YP_002409133.1 CDS gudD NC_011750.1 3346636 3347976 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20233700, 9772162, 10762278, 13971911; Product type e : enzyme; (D)-glucarate dehydratase 1 complement(3346636..3347976) Escherichia coli IAI39 7150837 YP_002409134.1 CDS gudX NC_011750.1 3347997 3349337 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9772162; Product type e : enzyme; glucarate dehydratase complement(3347997..3349337) Escherichia coli IAI39 7151600 YP_002409135.1 CDS gudP NC_011750.1 3349339 3350691 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10762278; Product type pt : putative transporter; putative D-glucarate transporter complement(3349339..3350691) Escherichia coli IAI39 7151602 YP_002409136.1 CDS yqcA NC_011750.1 3351126 3351575 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(3351126..3351575) Escherichia coli IAI39 7151601 YP_002409137.1 CDS truC NC_011750.1 3351593 3352375 R catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C complement(3351593..3352375) Escherichia coli IAI39 7154499 YP_002409138.1 CDS yqcC NC_011750.1 3352375 3352704 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3352375..3352704) Escherichia coli IAI39 7153041 YP_002409139.1 CDS syd NC_011750.1 3353326 3353871 R putative SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd complement(3353326..3353871) Escherichia coli IAI39 7151022 YP_002409140.1 CDS queF NC_011750.1 3353939 3354787 D catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 3353939..3354787 Escherichia coli IAI39 7152934 YP_002409141.1 CDS ygdH NC_011750.1 3354899 3356263 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3354899..3356263 Escherichia coli IAI39 7152562 YP_002409142.1 CDS sdaC NC_011750.1 3356819 3358108 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8752353, 8026499; Product type pt : putative transporter; putative serine transporter 3356819..3358108 Escherichia coli IAI39 7153946 YP_002409143.1 CDS sdaB NC_011750.1 3358166 3359533 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91193203, 93215657, 8385012; Product type e : enzyme; L-serine deaminase II 3358166..3359533 Escherichia coli IAI39 7152812 YP_002409144.1 CDS xni NC_011750.1 3359555 3360400 D has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 3359555..3360400 Escherichia coli IAI39 7152811 YP_002409145.1 CDS fucO NC_011750.1 3360505 3361656 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 89291720, 2553671, 2661535, 2664711, 8385012; Product type e : enzyme; L-1,2-propanediol oxidoreductase complement(3360505..3361656) Escherichia coli IAI39 7151259 YP_002409146.1 CDS fucA NC_011750.1 3361681 3362328 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase complement(3361681..3362328) Escherichia coli IAI39 7151449 YP_002409147.1 CDS fucP NC_011750.1 3362875 3364191 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 90036697, 2553671, 2664711, 7783647; Product type t : transporter; L-fucose transporter 3362875..3364191 Escherichia coli IAI39 7151446 YP_002409148.1 CDS fucI NC_011750.1 3364224 3365999 D catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 3364224..3365999 Escherichia coli IAI39 7151450 YP_002409149.1 CDS fucK NC_011750.1 3366078 3367526 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 90036697, 2664711, 13905785; Product type e : enzyme; L-fuculokinase 3366078..3367526 Escherichia coli IAI39 7151447 YP_002409150.1 CDS fucU NC_011750.1 3367528 3367950 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15060078, 12738765, 80049526, 2664711; Product type e : enzyme; L-fucose mutarotase 3367528..3367950 Escherichia coli IAI39 7151448 YP_002409151.1 CDS fucR NC_011750.1 3368008 3368739 D regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 3368008..3368739 Escherichia coli IAI39 7151452 YP_002409152.1 CDS ygdE NC_011750.1 3368783 3369883 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 21188420, 7704273; Product type pe : putative enzyme; putative RNA 2'-O-ribose methyltransferase complement(3368783..3369883) Escherichia coli IAI39 7151451 YP_002409153.1 CDS ygdD NC_011750.1 3369876 3370271 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7704273; Product type pm : putative membrane component; hypothetical protein complement(3369876..3370271) Escherichia coli IAI39 7153945 YP_002409154.1 CDS gcvA NC_011750.1 3370290 3371207 R Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA complement(3370290..3371207) Escherichia coli IAI39 7153944 YP_002409155.1 CDS ygdI NC_011750.1 3371558 3371785 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3371558..3371785) Escherichia coli IAI39 7151496 YP_002409156.1 CDS csdA NC_011750.1 3371977 3373182 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15148362, 9278392, 10739946, 10829016; Product type e : enzyme; cysteine sulfinate desulfinase 3371977..3373182 Escherichia coli IAI39 7153947 YP_002409157.1 CDS ygdK NC_011750.1 3373182 3373625 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative Fe-S metabolism protein (sufE-like) 3373182..3373625 Escherichia coli IAI39 7151002 YP_002409158.1 CDS ygdL NC_011750.1 3373676 3374482 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3373676..3374482) Escherichia coli IAI39 7153948 YP_002409159.1 CDS mltA NC_011750.1 3374721 3375818 R membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A complement(3374721..3375818) Escherichia coli IAI39 7153949 YP_002409160.1 CDS amiC NC_011750.1 3376289 3377542 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12787347, 21348478; Product type e : enzyme; N-acetylmuramoyl-L-alanine amidase complement(3376289..3377542) Escherichia coli IAI39 7150569 YP_002409161.1 CDS argA NC_011750.1 3377774 3379105 D catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 3377774..3379105 Escherichia coli IAI39 7150727 YP_002409162.1 CDS recD NC_011750.1 3379167 3380993 R helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha complement(3379167..3380993) Escherichia coli IAI39 7150760 YP_002409163.1 CDS recB NC_011750.1 3380993 3384535 R helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta complement(3380993..3384535) Escherichia coli IAI39 7152590 YP_002409164.1 CDS ptr NC_011750.1 3384528 3387416 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91193232, 1570301, 3308636, 3534791, 3537960, 8099278; Product type e : enzyme; protease III complement(3384528..3387416) Escherichia coli IAI39 7152588 YP_002409165.1 CDS recC NC_011750.1 3387592 3390960 R catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma complement(3387592..3390960) Escherichia coli IAI39 7152515 YP_002409166.1 CDS ppdC NC_011750.1 3390973 3391296 R Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein complement(3390973..3391296) Escherichia coli IAI39 7152589 YP_002409167.1 CDS ygdB NC_011750.1 3391281 3391688 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3391281..3391688) Escherichia coli IAI39 7152456 YP_002409168.1 CDS ppdB NC_011750.1 3391685 3392248 R Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein complement(3391685..3392248) Escherichia coli IAI39 7153943 YP_002409169.1 CDS ppdA NC_011750.1 3392239 3392709 R Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein complement(3392239..3392709) Escherichia coli IAI39 7152455 YP_002409170.1 CDS thyA NC_011750.1 3392894 3393688 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(3392894..3393688) Escherichia coli IAI39 7152454 YP_002409171.1 CDS lgt NC_011750.1 3393695 3394570 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(3393695..3394570) Escherichia coli IAI39 7152982 YP_002409172.1 CDS ptsP NC_011750.1 3394721 3396967 R member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain complement(3394721..3396967) Escherichia coli IAI39 7151933 YP_002409173.1 CDS nudH NC_011750.1 3396980 3397510 R hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase complement(3396980..3397510) Escherichia coli IAI39 7152522 YP_002409174.1 CDS ECIAI39_3250 NC_011750.1 3397955 3398116 D hypothetical protein 3397955..3398116 Escherichia coli IAI39 7152268 YP_002409175.1 CDS mutH NC_011750.1 3398195 3398884 D MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 3398195..3398884 Escherichia coli IAI39 7150141 YP_002409176.1 CDS ygdQ NC_011750.1 3398953 3399666 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3398953..3399666 Escherichia coli IAI39 7152155 YP_002409177.1 CDS ygdR NC_011750.1 3399804 3400022 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3399804..3400022 Escherichia coli IAI39 7153950 YP_002409178.1 CDS tas NC_011750.1 3400130 3401170 D complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; putative aldo-keto reductase 3400130..3401170 Escherichia coli IAI39 7153951 YP_002409179.1 CDS ygeD NC_011750.1 3401202 3402395 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8300626; Product type pm : putative membrane component; lysophospholipid transporter LplT complement(3401202..3402395) Escherichia coli IAI39 7152942 YP_002409180.1 CDS aas NC_011750.1 3402388 3404547 R Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase complement(3402388..3404547) Escherichia coli IAI39 7153953 YP_002409181.1 CDS galR NC_011750.1 3405133 3406164 D controls transcription of galETKM; DNA-binding transcriptional regulator GalR 3405133..3406164 Escherichia coli IAI39 7152301 YP_002409182.1 CDS lysA NC_011750.1 3406171 3407433 R catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase complement(3406171..3407433) Escherichia coli IAI39 7151475 YP_002409183.1 CDS lysR NC_011750.1 3407555 3408490 D activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; DNA-binding transcriptional regulator LysR 3407555..3408490 Escherichia coli IAI39 7151982 YP_002409184.1 CDS ygeA NC_011750.1 3408477 3409169 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15135544; Product type pe : putative enzyme; putative racemase complement(3408477..3409169) Escherichia coli IAI39 7151985 YP_002409185.1 CDS araE NC_011750.1 3409298 3410716 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7030324, 90239116, 91154204, 2836407, 3543693, 6319708; Product type t : transporter; arabinose transporter complement(3409298..3410716) Escherichia coli IAI39 7153952 YP_002409186.1 CDS kduD NC_011750.1 3411031 3411792 R catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase complement(3411031..3411792) Escherichia coli IAI39 7150751 YP_002409187.1 CDS kduI NC_011750.1 3411822 3412658 R 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase complement(3411822..3412658) Escherichia coli IAI39 7151890 YP_002409188.1 CDS yqeF NC_011750.1 3412945 3414126 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase complement(3412945..3414126) Escherichia coli IAI39 7151891 YP_002409189.1 CDS yqeG NC_011750.1 3414381 3415610 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3414381..3415610 Escherichia coli IAI39 7154506 YP_002409190.1 CDS yqeH NC_011750.1 3416070 3416702 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3416070..3416702 Escherichia coli IAI39 7154507 YP_002409191.1 CDS yqeI NC_011750.1 3417036 3417845 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3417036..3417845 Escherichia coli IAI39 7154508 YP_002409192.1 CDS yqeJ NC_011750.1 3417838 3418320 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3417838..3418320 Escherichia coli IAI39 7154509 YP_002409193.1 CDS ECIAI39_3270 NC_011750.1 3419033 3419269 R hypothetical protein complement(3419033..3419269) Escherichia coli IAI39 7154511 YP_002409194.1 CDS ygeF NC_011750.1 3419323 3419760 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3419323..3419760 Escherichia coli IAI39 7150142 YP_002409195.1 CDS ygeG NC_011750.1 3420045 3420536 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative chaperone 3420045..3420536 Escherichia coli IAI39 7153954 YP_002409196.1 CDS ygeH NC_011750.1 3420871 3422247 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15150243; Product type pr : putative regulator; transcriptional regulator 3420871..3422247 Escherichia coli IAI39 7153955 YP_002409197.1 CDS ygeI NC_011750.1 3422373 3422633 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3422373..3422633 Escherichia coli IAI39 7153956 YP_002409198.1 CDS ECIAI39_3275 NC_011750.1 3422717 3423220 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative peptidoglycan-binding-like protein 3422717..3423220 Escherichia coli IAI39 7153957 YP_002409199.1 CDS insB NC_011750.1 3423343 3423846 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' complement(3423343..3423846) Escherichia coli IAI39 7150143 YP_002409200.1 CDS insA NC_011750.1 3423765 3424040 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA complement(3423765..3424040) Escherichia coli IAI39 7151797 YP_002409201.1 CDS ECIAI39_3278 NC_011750.1 3424183 3424362 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3424183..3424362) Escherichia coli IAI39 7151786 YP_002409202.1 CDS ECIAI39_3279 NC_011750.1 3424429 3426081 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3424429..3426081) Escherichia coli IAI39 7150144 YP_002409203.1 CDS ygeR NC_011750.1 3426424 3427200 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15150243; Product type r : regulator; Tetratricopeptide repeat transcriptional regulator complement(3426424..3427200) Escherichia coli IAI39 7150596 YP_002409204.1 CDS xdhA NC_011750.1 3427631 3429889 D putative molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 3427631..3429889 Escherichia coli IAI39 7153958 YP_002409205.1 CDS xdhB NC_011750.1 3429900 3430778 D FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 3429900..3430778 Escherichia coli IAI39 7153175 YP_002409206.1 CDS xdhC NC_011750.1 3430775 3431254 D iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 3430775..3431254 Escherichia coli IAI39 7153176 YP_002409207.1 CDS ygeV NC_011750.1 3431294 3433072 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3431294..3433072) Escherichia coli IAI39 7153177 YP_002409208.1 CDS ygeW NC_011750.1 3433548 3434738 D Evidence 4 : Homologs of previously reported genes of unknown function; aspartate/ornithine carbamoyltransferase family protein 3433548..3434738 Escherichia coli IAI39 7153959 YP_002409209.1 CDS ygeX NC_011750.1 3434796 3435992 D catalyzes the formation of pyruvate from 2,3-diaminopropionate; diaminopropionate ammonia-lyase 3434796..3435992 Escherichia coli IAI39 7153960 YP_002409210.1 CDS ygeY NC_011750.1 3436050 3437261 D Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases; peptidase 3436050..3437261 Escherichia coli IAI39 7153961 YP_002409211.1 CDS hyuA NC_011750.1 3437314 3438699 D catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; phenylhydantoinase 3437314..3438699 Escherichia coli IAI39 7153962 YP_002409212.1 CDS yqeA NC_011750.1 3438747 3439679 D catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 3438747..3439679 Escherichia coli IAI39 7151739 YP_002409213.1 CDS yqeB NC_011750.1 3439720 3441345 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3439720..3441345) Escherichia coli IAI39 7154503 YP_002409214.1 CDS yqeC NC_011750.1 3441393 3442163 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3441393..3442163) Escherichia coli IAI39 7154504 YP_002409215.1 CDS ygfJ NC_011750.1 3442266 3442844 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3442266..3442844 Escherichia coli IAI39 7154505 YP_002409216.1 CDS ygfK NC_011750.1 3443166 3446264 D with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase; putative selenate reductase subunit YgfK 3443166..3446264 Escherichia coli IAI39 7153968 YP_002409217.1 CDS ssnA NC_011750.1 3446267 3447595 D in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS; putative chlorohydrolase/aminohydrolase 3446267..3447595 Escherichia coli IAI39 7153969 YP_002409218.1 CDS ygfM NC_011750.1 3447646 3448425 D with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain; putative selenate reductase subunit YgfM 3447646..3448425 Escherichia coli IAI39 7152905 YP_002409219.1 CDS xdhD NC_011750.1 3448422 3451292 D with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration; putative selenate reductase subunit YgfN 3448422..3451292 Escherichia coli IAI39 7153970 YP_002409220.1 CDS ygfO NC_011750.1 3451457 3452857 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20372655, 98213740; Product type pt : putative transporter; putative transporter 3451457..3452857 Escherichia coli IAI39 7153178 YP_002409221.1 CDS guaD NC_011750.1 3452872 3454191 D Catalyzes the deamination of guanine; guanine deaminase 3452872..3454191 Escherichia coli IAI39 7153971 YP_002409222.1 CDS ygfQ NC_011750.1 3454227 3455594 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3454227..3455594 Escherichia coli IAI39 7151599 YP_002409223.1 CDS ygfS NC_011750.1 3455630 3456118 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative oxidoreductase complement(3455630..3456118) Escherichia coli IAI39 7153972 YP_002409224.1 CDS ygfT NC_011750.1 3456118 3458037 R unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); putative oxidoreductase complement(3456118..3458037) Escherichia coli IAI39 7153973 YP_002409225.1 CDS ECIAI39_3302 NC_011750.1 3458340 3458528 D Evidence 6 : Doubtful CDS; hypothetical protein 3458340..3458528 Escherichia coli IAI39 7153974 YP_002409226.1 CDS ygfU NC_011750.1 3458473 3459921 D Evidence 2b : Function of strongly homologous gene; PubMedId : 9098051; Product type t : transporter; transporter 3458473..3459921 Escherichia coli IAI39 7150146 YP_002409227.1 CDS idi NC_011750.1 3460170 3460718 D catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 3460170..3460718 Escherichia coli IAI39 7153975 YP_002409228.1 CDS lysS NC_011750.1 3460761 3462278 R class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(3460761..3462278) Escherichia coli IAI39 7151753 YP_002409229.1 CDS prfB NC_011750.1 3462288 3463386 R recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 complement(join(3462288..3463310,3463312..3463386)) Escherichia coli IAI39 7151986 YP_002409230.1 CDS recJ NC_011750.1 3463477 3465210 R 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ complement(3463477..3465210) Escherichia coli IAI39 7152473 YP_002409231.1 CDS dsbC NC_011750.1 3465216 3465926 R DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC complement(3465216..3465926) Escherichia coli IAI39 7152593 YP_002409232.1 CDS xerD NC_011750.1 3465951 3466847 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD complement(3465951..3466847) Escherichia coli IAI39 7151174 YP_002409233.1 CDS fldB NC_011750.1 3466959 3467480 D An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 3466959..3467480 Escherichia coli IAI39 7153180 YP_002409234.1 CDS ygfX NC_011750.1 3467520 3467927 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3467520..3467927) Escherichia coli IAI39 7151348 YP_002409235.1 CDS ygfY NC_011750.1 3467908 3468174 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3467908..3468174) Escherichia coli IAI39 7153976 YP_002409236.1 CDS ygfZ NC_011750.1 3468417 3469397 D physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; putative global regulator 3468417..3469397 Escherichia coli IAI39 7153977 YP_002409237.1 CDS yqfA NC_011750.1 3469474 3470133 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative hemolysin, inner membrane subunit complement(3469474..3470133) Escherichia coli IAI39 7153978 YP_002409238.1 CDS yqfB NC_011750.1 3470297 3470608 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3470297..3470608) Escherichia coli IAI39 7154512 YP_002409239.1 CDS bglA NC_011750.1 3470647 3472086 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 88297127, 92334140; Product type e : enzyme; 6-phospho-beta-glucosidase A 3470647..3472086 Escherichia coli IAI39 7154513 YP_002409240.1 CDS gcvP NC_011750.1 3472252 3475125 R acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase complement(3472252..3475125) Escherichia coli IAI39 7150859 YP_002409241.1 CDS gcvH NC_011750.1 3475243 3475632 R part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H complement(3475243..3475632) Escherichia coli IAI39 7151498 YP_002409242.1 CDS gcvT NC_011750.1 3475656 3476750 R catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T complement(3475656..3476750) Escherichia coli IAI39 7151497 YP_002409243.1 CDS visC NC_011750.1 3477198 3478400 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1339425; Product type pe : putative enzyme; hypothetical protein complement(3477198..3478400) Escherichia coli IAI39 7151500 YP_002409244.1 CDS ubiH NC_011750.1 3478423 3479601 R Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase complement(3478423..3479601) Escherichia coli IAI39 7153130 YP_002409245.1 CDS pepP NC_011750.1 3479598 3480923 R exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II complement(3479598..3480923) Escherichia coli IAI39 7153075 YP_002409246.1 CDS ygfB NC_011750.1 3480949 3481527 R the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein complement(3480949..3481527) Escherichia coli IAI39 7152366 YP_002409247.1 CDS zapA NC_011750.1 3481695 3482024 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 412171; Product type cp : cell process; Z-ring-associated protein 3481695..3482024 Escherichia coli IAI39 7153964 YP_002409248.1 CDS ygfA NC_011750.1 3482324 3482872 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14727089, 2579060; Product type pe : putative enzyme; putative ligase 3482324..3482872 Escherichia coli IAI39 7152909 YP_002409249.1 CDS serA NC_011750.1 3483261 3484493 R catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase complement(3483261..3484493) Escherichia coli IAI39 7152789 YP_002409250.1 CDS rpiA NC_011750.1 3484749 3485408 R Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A complement(3484749..3485408) Escherichia coli IAI39 7152830 YP_002409251.1 CDS argP NC_011750.1 3485791 3486684 D specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 3485791..3486684 Escherichia coli IAI39 7152668 YP_002409252.1 CDS yliK NC_011750.1 3486888 3489032 D MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 3486888..3489032 Escherichia coli IAI39 7150770 YP_002409253.1 CDS argK NC_011750.1 3489025 3490020 D functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 3489025..3490020 Escherichia coli IAI39 7154379 YP_002409254.1 CDS ygfG NC_011750.1 3490031 3490816 D catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA; methylmalonyl-CoA decarboxylase 3490031..3490816 Escherichia coli IAI39 7150768 YP_002409255.1 CDS ygfH NC_011750.1 3490840 3492318 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20233703; Product type e : enzyme; propionyl-CoA:succinate-CoA transferase 3490840..3492318 Escherichia coli IAI39 7153965 YP_002409256.1 CDS ygfI NC_011750.1 3492315 3493211 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3492315..3493211) Escherichia coli IAI39 7153966 YP_002409257.1 CDS yggE NC_011750.1 3493379 3494119 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3493379..3494119) Escherichia coli IAI39 7153967 YP_002409258.1 CDS argO NC_011750.1 3494212 3494847 R Involved in the export of arginine; arginine exporter protein complement(3494212..3494847) Escherichia coli IAI39 7153981 YP_002409259.1 CDS mscS NC_011750.1 3494986 3495846 R participates in the regulation of osmotic pressure changes within the cel; mechanosensitive channel MscS complement(3494986..3495846) Escherichia coli IAI39 7150769 YP_002409260.1 CDS fbaA NC_011750.1 3496037 3497116 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase complement(3496037..3497116) Escherichia coli IAI39 7152133 YP_002409261.1 CDS pgk NC_011750.1 3497331 3498494 R Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase complement(3497331..3498494) Escherichia coli IAI39 7151279 YP_002409262.1 CDS epd NC_011750.1 3498544 3499563 R NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase complement(3498544..3499563) Escherichia coli IAI39 7152382 YP_002409263.1 CDS ECIAI39_3342 NC_011750.1 3499935 3500366 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3499935..3500366 Escherichia coli IAI39 7151232 YP_002409264.1 CDS ECIAI39_3343 NC_011750.1 3500290 3500967 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC-type transport system 3500290..3500967 Escherichia coli IAI39 7150147 YP_002409265.1 CDS ECIAI39_3344 NC_011750.1 3500968 3501675 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC-type transport system 3500968..3501675 Escherichia coli IAI39 7150148 YP_002409266.1 CDS ECIAI39_3345 NC_011750.1 3501657 3502340 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ATP-binding protein of ABC transport system 3501657..3502340 Escherichia coli IAI39 7150149 YP_002409267.1 CDS ECIAI39_3346 NC_011750.1 3502301 3503011 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ATP-binding protein of ABC transport system 3502301..3503011 Escherichia coli IAI39 7150150 YP_002409268.1 CDS frcK NC_011750.1 3502983 3503696 R Evidence 4 : Homologs of previously reported genes of unknown function; putative fructose transport system kinase complement(3502983..3503696) Escherichia coli IAI39 7150151 YP_002409269.1 CDS yggD NC_011750.1 3503693 3504202 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3503693..3504202) Escherichia coli IAI39 7153979 YP_002409270.1 CDS yggF NC_011750.1 3504224 3505189 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; fructose-1,6-bisphosphatase II-like protein complement(3504224..3505189) Escherichia coli IAI39 7153980 YP_002409271.1 CDS yggP NC_011750.1 3505186 3506463 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative dehydrogenase complement(3505186..3506463) Escherichia coli IAI39 7153982 YP_002409272.1 CDS cmtA NC_011750.1 3506478 3507866 R Evidence 2b : Function of strongly homologous gene; PubMedId : 8353127; Product type t : transporter; PTS system mannitol-specific transporter subunit IIBC complement(3506478..3507866) Escherichia coli IAI39 7153989 YP_002409273.1 CDS cmtB NC_011750.1 3507894 3508337 R TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein; putative mannitol phosphotransferase subunit EIIA complement(3507894..3508337) Escherichia coli IAI39 7150971 YP_002409274.1 CDS ECIAI39_3353 NC_011750.1 3508678 3509622 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane protease 3508678..3509622 Escherichia coli IAI39 7150972 YP_002409275.1 CDS tktA NC_011750.1 3509668 3511659 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(3509668..3511659) Escherichia coli IAI39 7150152 YP_002409276.1 CDS yggG NC_011750.1 3511937 3512695 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1310091; Product type pe : putative enzyme; putative peptidase 3511937..3512695 Escherichia coli IAI39 7152989 YP_002409277.1 CDS speB NC_011750.1 3512743 3513663 R catalyzes the formation of putrescine from agmatine; agmatinase complement(3512743..3513663) Escherichia coli IAI39 7153983 YP_002409278.1 CDS ECIAI39_3357 NC_011750.1 3513799 3514530 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3513799..3514530) Escherichia coli IAI39 7152880 YP_002409279.1 CDS speA NC_011750.1 3514676 3516652 R catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase complement(3514676..3516652) Escherichia coli IAI39 7150153 YP_002409280.1 CDS yqgB NC_011750.1 3516661 3516807 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3516661..3516807) Escherichia coli IAI39 7152879 YP_002409281.1 CDS metK NC_011750.1 3517447 3518601 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3517447..3518601 Escherichia coli IAI39 7154515 YP_002409282.1 CDS galP NC_011750.1 3519037 3520431 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9182541; Product type t : transporter; D-galactose transporter 3519037..3520431 Escherichia coli IAI39 7152059 YP_002409283.1 CDS sprT NC_011750.1 3520508 3521005 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7984428, 8113204; hypothetical protein 3520508..3521005 Escherichia coli IAI39 7151474 YP_002409284.1 CDS endA NC_011750.1 3521100 3521807 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 72060411, 92335461, 4955462, 7867949, 8113204; Product type e : enzyme; DNA-specific endonuclease I 3521100..3521807 Escherichia coli IAI39 7152890 YP_002409285.1 CDS yggJ NC_011750.1 3521887 3522618 D in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3521887..3522618 Escherichia coli IAI39 7151220 YP_002409286.1 CDS gshB NC_011750.1 3522631 3523581 D catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3522631..3523581 Escherichia coli IAI39 7153985 YP_002409287.1 CDS yqgE NC_011750.1 3523690 3524253 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3523690..3524253 Escherichia coli IAI39 7151592 YP_002409288.1 CDS yqgF NC_011750.1 3524253 3524669 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3524253..3524669 Escherichia coli IAI39 7154516 YP_002409289.1 CDS yggR NC_011750.1 3524844 3525824 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1676385; Product type t : transporter; transporter complement(3524844..3525824) Escherichia coli IAI39 7154517 YP_002409290.1 CDS yggS NC_011750.1 3525842 3526546 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3525842..3526546 Escherichia coli IAI39 7153990 YP_002409291.1 CDS yggT NC_011750.1 3526564 3527130 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3526564..3527130 Escherichia coli IAI39 7153991 YP_002409292.1 CDS yggU NC_011750.1 3527127 3527417 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12975589; hypothetical protein 3527127..3527417 Escherichia coli IAI39 7153992 YP_002409293.1 CDS yggV NC_011750.1 3527425 3528018 D HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 3527425..3528018 Escherichia coli IAI39 7153993 YP_002409294.1 CDS yggW NC_011750.1 3528011 3529147 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3528011..3529147 Escherichia coli IAI39 7153994 YP_002409295.1 CDS ECIAI39_3374 NC_011750.1 3529460 3530446 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative c4-dicarboxylate transport system binding protein 3529460..3530446 Escherichia coli IAI39 7153995 YP_002409296.1 CDS ECIAI39_3375 NC_011750.1 3530482 3530994 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative TRAP-type C4-dicarboxylate transport system, small permease component 3530482..3530994 Escherichia coli IAI39 7150154 YP_002409297.1 CDS ECIAI39_3377 NC_011750.1 3531641 3531967 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 3531641..3531967 Escherichia coli IAI39 7150156 YP_002409298.1 CDS ECIAI39_3378 NC_011750.1 3531964 3532854 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 3531964..3532854 Escherichia coli IAI39 7150157 YP_002409299.1 CDS yggM NC_011750.1 3533664 3534671 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3533664..3534671) Escherichia coli IAI39 7154017 YP_002409300.1 CDS ansB NC_011750.1 3534788 3535834 R catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II complement(3534788..3535834) Escherichia coli IAI39 7153987 YP_002409301.1 CDS yggN NC_011750.1 3536010 3536729 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein complement(3536010..3536729) Escherichia coli IAI39 7150738 YP_002409302.1 CDS yggL NC_011750.1 3536913 3537239 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3536913..3537239) Escherichia coli IAI39 7153988 YP_002409303.1 CDS trmB NC_011750.1 3537239 3537958 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(3537239..3537958) Escherichia coli IAI39 7153986 YP_002409304.1 CDS mutY NC_011750.1 3538119 3539171 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14730969, 20187555, 20316830, 20580749, 21438845, 90046892, 92409600, 9801309, 2001994, 2197596, 9846876; Product type e : enzyme; adenine DNA glycosylase 3538119..3539171 Escherichia coli IAI39 7153984 YP_002409305.1 CDS yggX NC_011750.1 3539199 3539474 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594836, 10493123, 9298646, 9868784; Product type f : factor; hypothetical protein 3539199..3539474 Escherichia coli IAI39 7152160 YP_002409306.1 CDS mltC NC_011750.1 3539539 3540618 D Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3539539..3540618 Escherichia coli IAI39 7153996 YP_002409307.1 CDS nupG NC_011750.1 3540820 3542076 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88029453, 90323001, 3311747; Product type t : transporter; nucleoside transporter 3540820..3542076 Escherichia coli IAI39 7152091 YP_002409308.1 CDS speC NC_011750.1 3542125 3544260 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 87260820; Product type e : enzyme; ornithine decarboxylase complement(3542125..3544260) Escherichia coli IAI39 7152283 YP_002409309.1 CDS yqgA NC_011750.1 3544653 3545360 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3544653..3545360 Escherichia coli IAI39 7152881 YP_002409310.1 CDS int NC_011750.1 3545739 3547004 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Prophage integrase 3545739..3547004 Escherichia coli IAI39 7150570 YP_002409311.1 CDS ECIAI39_3392 NC_011750.1 3547230 3548303 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411725; Product type pe : putative enzyme; SHI-2 pathogenicity island protein 3547230..3548303 Escherichia coli IAI39 7151830 YP_002409312.1 CDS insA NC_011750.1 3548833 3549108 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 3548833..3549108 Escherichia coli IAI39 7150159 YP_002409313.1 CDS insB NC_011750.1 3549027 3549530 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 3549027..3549530 Escherichia coli IAI39 7151787 YP_002409314.1 CDS ECIAI39_3395 NC_011750.1 3549997 3550548 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative HTH-type transcriptional regulator complement(3549997..3550548) Escherichia coli IAI39 7151798 YP_002409315.1 CDS ECIAI39_3396 NC_011750.1 3550715 3551083 R hypothetical protein complement(3550715..3551083) Escherichia coli IAI39 7150160 YP_002409316.1 CDS ECIAI39_3397 NC_011750.1 3551553 3551804 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase ORF A, IS3 family complement(3551553..3551804) Escherichia coli IAI39 7150161 YP_002409317.1 CDS papF NC_011750.1 3553058 3553591 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2869489, 2895103, 1357526, 8096174, 10049807; Product type s : structure; fimbrial adapter PapF complement(3553058..3553591) Escherichia coli IAI39 7152340 YP_002409318.1 CDS papE NC_011750.1 3553636 3554175 R Evidence 2b : Function of strongly homologous gene; PubMedId : 2869489, 2895103, 1357526, 10049807; Product type s : structure; fimbrial tip protein PapE complement(3553636..3554175) Escherichia coli IAI39 7152337 YP_002409319.1 CDS insB NC_011750.1 3554212 3554715 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' complement(3554212..3554715) Escherichia coli IAI39 7152335 YP_002409320.1 CDS insA NC_011750.1 3554634 3554909 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA complement(3554634..3554909) Escherichia coli IAI39 7151799 YP_002409321.1 CDS papI NC_011750.1 3556432 3556665 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2868893, 1357526; Product type r : regulator; pap operon regulatory protein PapI 3556432..3556665 Escherichia coli IAI39 7152331 YP_002409322.1 CDS ECIAI39_3408 NC_011750.1 3556811 3557257 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 complement(3556811..3557257) Escherichia coli IAI39 7152343 YP_002409323.1 CDS ECIAI39_3409 NC_011750.1 3557374 3558897 R Group II intron-encoded reverse transcriptase/maturase complement(3557374..3558897) Escherichia coli IAI39 7150542 YP_002409324.1 CDS ECIAI39_3410 NC_011750.1 3559489 3559779 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 complement(3559489..3559779) Escherichia coli IAI39 7150164 YP_002409325.1 CDS ECIAI39_3413 NC_011750.1 3561115 3561915 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase IstB, IS21 3561115..3561915 Escherichia coli IAI39 7150167 YP_002409326.1 CDS ECIAI39_3414 NC_011750.1 3561955 3562104 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 complement(3561955..3562104) Escherichia coli IAI39 7150168 YP_002409327.1 CDS ECIAI39_3415 NC_011750.1 3562104 3562430 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 complement(3562104..3562430) Escherichia coli IAI39 7150169 YP_002409328.1 CDS ECIAI39_3416 NC_011750.1 3563170 3563916 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; putative transposase (fragment) complement(3563170..3563916) Escherichia coli IAI39 7150170 YP_002409329.1 CDS ECIAI39_3417 NC_011750.1 3564462 3564728 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3564462..3564728 Escherichia coli IAI39 7150171 YP_002409330.1 CDS ECIAI39_3418 NC_011750.1 3564770 3565330 D Evidence 4 : Homologs of previously reported genes of unknown function; putative transcriptional regulator 3564770..3565330 Escherichia coli IAI39 7150172 YP_002409331.1 CDS ECIAI39_3419 NC_011750.1 3565340 3565798 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3565340..3565798 Escherichia coli IAI39 7150173 YP_002409332.1 CDS insC NC_011750.1 3566462 3566836 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type r : regulator; IS2 insertion element repressor InsA; KpLE2 phage-like element 3566462..3566836 Escherichia coli IAI39 7150174 YP_002409333.1 CDS insD NC_011750.1 3566829 3567734 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS2 insertion element transposase InsAB'; CP4-44 prophage 3566829..3567734 Escherichia coli IAI39 7151804 YP_002409334.1 CDS shiF NC_011750.1 3567847 3569040 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411725; Product type pt : putative transporter; putative membrane transport protein, major facilitator superfamily complement(3567847..3569040) Escherichia coli IAI39 7151807 YP_002409335.1 CDS iucA NC_011750.1 3569110 3570900 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3087960; Product type e : enzyme; aerobactin siderophore biosynthesis protein 3569110..3570900 Escherichia coli IAI39 7152851 YP_002409336.1 CDS iucB NC_011750.1 3570901 3571848 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3087960; Product type e : enzyme; aerobactin siderophore biosynthesis N(6)-hydroxylysine acetylase 3570901..3571848 Escherichia coli IAI39 7151862 YP_002409337.1 CDS iucC NC_011750.1 3571848 3573590 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3087960; Product type e : enzyme; Aerobactin siderophore biosynthesis protein 3571848..3573590 Escherichia coli IAI39 7151863 YP_002409338.1 CDS iucD NC_011750.1 3573587 3574864 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3275632, 10064136; Product type e : enzyme; L-lysine 6-monooxygenase 3573587..3574864 Escherichia coli IAI39 7151864 YP_002409339.1 CDS iutA NC_011750.1 3574946 3577147 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4313071, 6456229, 7044820, 7042696, 6749806; Product type rc : receptor; Ferric aerobactin receptor 3574946..3577147 Escherichia coli IAI39 7151865 YP_002409340.1 CDS ECIAI39_3429 NC_011750.1 3580474 3580800 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 3580474..3580800 Escherichia coli IAI39 7152803 YP_002409341.1 CDS ECIAI39_3430 NC_011750.1 3580797 3581279 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 3580797..3581279 Escherichia coli IAI39 7150175 YP_002409342.1 CDS ECIAI39_3431 NC_011750.1 3581871 3583394 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9353259, 10413481; Product type e : enzyme; Group II intron-encoded reverse transcriptase/maturase 3581871..3583394 Escherichia coli IAI39 7150176 YP_002409343.1 CDS ECIAI39_3432 NC_011750.1 3583511 3583957 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 3583511..3583957 Escherichia coli IAI39 7150543 YP_002409344.1 CDS kpsE NC_011750.1 3584271 3585419 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8253690; Product type t : transporter; capsule polysaccharide export inner-membrane protein 3584271..3585419 Escherichia coli IAI39 7151903 YP_002409345.1 CDS kpsD NC_011750.1 3585440 3587119 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8021185; Product type t : transporter; polysialic acid transport protein 3585440..3587119 Escherichia coli IAI39 7151902 YP_002409346.1 CDS kpsU NC_011750.1 3587129 3587869 D CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 3587129..3587869 Escherichia coli IAI39 7151901 YP_002409347.1 CDS kpsC NC_011750.1 3587866 3589893 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8397187, 8326861; Product type t : transporter; capsule polysaccharide export protein 3587866..3589893 Escherichia coli IAI39 7151907 YP_002409348.1 CDS kpsS NC_011750.1 3589928 3591133 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8397187, 8326861; Product type t : transporter; capsule polysaccharide export protein 3589928..3591133 Escherichia coli IAI39 7151900 YP_002409349.1 CDS neuS NC_011750.1 3591283 3592512 R Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme; poly-alpha-2,8 sialosyl sialyltransferase complement(3591283..3592512) Escherichia coli IAI39 7151905 YP_002409350.1 CDS neuE NC_011750.1 3592502 3593650 R Evidence 2b : Function of strongly homologous gene; PubMedId : 16484189, 1735705; Product type e : enzyme; polysialic acid biosynthesis protein complement(3592502..3593650) Escherichia coli IAI39 7152212 YP_002409351.1 CDS neuC NC_011750.1 3593643 3594818 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14729696, 1729218; Product type e : enzyme; UDP-N-acetylglucosamine 2-epimerase complement(3593643..3594818) Escherichia coli IAI39 7152210 YP_002409352.1 CDS neuA NC_011750.1 3594815 3596071 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2549035; Product type e : enzyme; N-acylneuraminate cytidylyltransferase complement(3594815..3596071) Escherichia coli IAI39 7152208 YP_002409353.1 CDS neuB NC_011750.1 3596071 3597111 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7814319; Product type e : enzyme; N-acylneuraminate-9-phosphate synthase complement(3596071..3597111) Escherichia coli IAI39 7152206 YP_002409354.1 CDS neuD NC_011750.1 3597108 3597731 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10930752, 7814319; Product type e : enzyme; NeuD protein involved in sialic acid synthesis complement(3597108..3597731) Escherichia coli IAI39 7152207 YP_002409355.1 CDS kpsT NC_011750.1 3597781 3598440 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1856162, 8051103, 2082146; Product type t : transporter; polysialic acid transport ATP-binding protein complement(3597781..3598440) Escherichia coli IAI39 7152209 YP_002409356.1 CDS kpsM NC_011750.1 3598437 3599273 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1856162, 7715449; Product type t : transporter; polysialic acid transport protein complement(3598437..3599273) Escherichia coli IAI39 7151906 YP_002409357.1 CDS yghD NC_011750.1 3600272 3600808 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative general secretion pathway protein YghD complement(3600272..3600808) Escherichia coli IAI39 7151904 YP_002409358.1 CDS yghE NC_011750.1 3600810 3601988 R similar to general secretory pathway protein L; GspL-like protein complement(3600810..3601988) Escherichia coli IAI39 7153999 YP_002409359.1 CDS ECIAI39_3449 NC_011750.1 3601985 3602962 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; GspK-like type II secretion protein complement(3601985..3602962) Escherichia coli IAI39 7154000 YP_002409360.1 CDS ECIAI39_3450 NC_011750.1 3602959 3603564 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3602959..3603564) Escherichia coli IAI39 7150179 YP_002409361.1 CDS ECIAI39_3451 NC_011750.1 3603561 3603932 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative GspI-like type II secretion protein complement(3603561..3603932) Escherichia coli IAI39 7150180 YP_002409362.1 CDS ECIAI39_3452 NC_011750.1 3603929 3604492 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3603929..3604492) Escherichia coli IAI39 7150181 YP_002409363.1 CDS ECIAI39_3453 NC_011750.1 3604496 3604978 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative general secretion pathway protein G (epsG-like) complement(3604496..3604978) Escherichia coli IAI39 7150182 YP_002409364.1 CDS epsF NC_011750.1 3604968 3606191 R Evidence 2b : Function of strongly homologous gene; Product type t : transporter; General secretion pathway protein F complement(3604968..3606191) Escherichia coli IAI39 7150183 YP_002409365.1 CDS epsE NC_011750.1 3606191 3607684 R Evidence 2b : Function of strongly homologous gene; Product type t : transporter; general secretion pathway protein E complement(3606191..3607684) Escherichia coli IAI39 7151235 YP_002409366.1 CDS epsD NC_011750.1 3607684 3609744 R Evidence 2b : Function of strongly homologous gene; Product type t : transporter; general secretion pathway protein D complement(3607684..3609744) Escherichia coli IAI39 7151234 YP_002409367.1 CDS yghF NC_011750.1 3609774 3610733 R part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm; putative type II secretion protein GspC complement(3609774..3610733) Escherichia coli IAI39 7151233 YP_002409368.1 CDS yghG NC_011750.1 3610751 3611161 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3610751..3611161) Escherichia coli IAI39 7154001 YP_002409369.1 CDS pppA NC_011750.1 3611227 3612036 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98175453; Product type e : enzyme; bifunctional prepilin leader peptidase and methylase complement(3611227..3612036) Escherichia coli IAI39 7154002 YP_002409370.1 CDS yghJ NC_011750.1 3612166 3616740 R Evidence 2b : Function of strongly homologous gene; PubMedId : 1644747; Product type lp : lipoprotein; inner membrane lipoprotein complement(3612166..3616740) Escherichia coli IAI39 7152465 YP_002409371.1 CDS ECIAI39_3461 NC_011750.1 3616873 3617073 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3616873..3617073 Escherichia coli IAI39 7154003 YP_002409372.1 CDS yghK NC_011750.1 3617207 3618889 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11785976, 21178909, 11283302; Product type t : transporter; glycolate transporter complement(3617207..3618889) Escherichia coli IAI39 7150184 YP_002409373.1 CDS glcB NC_011750.1 3619244 3621415 R catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G complement(3619244..3621415) Escherichia coli IAI39 7150889 YP_002409374.1 CDS glcG NC_011750.1 3621437 3621841 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3621437..3621841) Escherichia coli IAI39 7151505 YP_002409375.1 CDS glcF NC_011750.1 3621846 3623069 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type c : carrier; glycolate oxidase iron-sulfur subunit complement(3621846..3623069) Escherichia coli IAI39 7151510 YP_002409376.1 CDS glcE NC_011750.1 3623080 3624132 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type e : enzyme; glycolate oxidase FAD binding subunit complement(3623080..3624132) Escherichia coli IAI39 7151509 YP_002409377.1 CDS glcD NC_011750.1 3624132 3625631 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type e : enzyme; glycolate oxidase subunit GlcD complement(3624132..3625631) Escherichia coli IAI39 7151508 YP_002409378.1 CDS glcC NC_011750.1 3625882 3626646 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 9880556, 8606183; Product type r : regulator; DNA-binding transcriptional regulator GlcC 3625882..3626646 Escherichia coli IAI39 7151507 YP_002409379.1 CDS yghO NC_011750.1 3626653 3627795 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3626653..3627795) Escherichia coli IAI39 7151506 YP_002409380.1 CDS ECIAI39_3471 NC_011750.1 3629884 3630798 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative epimerase 3629884..3630798 Escherichia coli IAI39 7150185 YP_002409381.1 CDS ECIAI39_3472 NC_011750.1 3630830 3631078 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3630830..3631078 Escherichia coli IAI39 7150186 YP_002409382.1 CDS ECIAI39_3473 NC_011750.1 3631078 3632250 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative 8-amino-7-oxononanoate synthase 3631078..3632250 Escherichia coli IAI39 7150187 YP_002409383.1 CDS ECIAI39_3474 NC_011750.1 3632285 3633364 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3632285..3633364) Escherichia coli IAI39 7150188 YP_002409384.1 CDS ECIAI39_3475 NC_011750.1 3633361 3634431 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3633361..3634431) Escherichia coli IAI39 7150189 YP_002409385.1 CDS ECIAI39_3476 NC_011750.1 3634462 3635025 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator complement(3634462..3635025) Escherichia coli IAI39 7150190 YP_002409386.1 CDS ECIAI39_3477 NC_011750.1 3635034 3635858 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3635034..3635858) Escherichia coli IAI39 7150191 YP_002409387.1 CDS ECIAI39_3478 NC_011750.1 3635858 3637207 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein complement(3635858..3637207) Escherichia coli IAI39 7150192 YP_002409388.1 CDS yghR NC_011750.1 3637253 3638011 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3637253..3638011) Escherichia coli IAI39 7150193 YP_002409389.1 CDS yghS NC_011750.1 3638043 3638756 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3638043..3638756) Escherichia coli IAI39 7154006 YP_002409390.1 CDS pitB NC_011750.1 3639670 3641169 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21336523, 21382172, 7775463; Product type t : transporter; phosphate transporter complement(3639670..3641169) Escherichia coli IAI39 7154009 YP_002409391.1 CDS gss NC_011750.1 3641461 3643320 R catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase complement(3641461..3643320) Escherichia coli IAI39 7152424 YP_002409392.1 CDS yghU NC_011750.1 3643525 3644391 D YghU; B2989; one of eight putative glutathione transferase proteins from E. coli; putative glutathione S-transferase YghU 3643525..3644391 Escherichia coli IAI39 7151594 YP_002409393.1 CDS hybG NC_011750.1 3644461 3644709 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 94292472, 8021226; Product type pf : putative factor; hydrogenase 2 accessory protein HypG complement(3644461..3644709) Escherichia coli IAI39 7154010 YP_002409394.1 CDS hybF NC_011750.1 3644722 3645063 R plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF complement(3644722..3645063) Escherichia coli IAI39 7151709 YP_002409395.1 CDS hybE NC_011750.1 3645056 3645544 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94292472, 8021226; Product type f : factor; hydrogenase 2-specific chaperone complement(3645056..3645544) Escherichia coli IAI39 7151708 YP_002409396.1 CDS hybD NC_011750.1 3645537 3646031 R protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase complement(3645537..3646031) Escherichia coli IAI39 7151707 YP_002409397.1 CDS hybC NC_011750.1 3646031 3647734 R involved in hydrogen uptake; hydrogenase 2 large subunit complement(3646031..3647734) Escherichia coli IAI39 7151706 YP_002409398.1 CDS hybB NC_011750.1 3647731 3648909 R HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; putative hydrogenase 2 b cytochrome subunit complement(3647731..3648909) Escherichia coli IAI39 7151705 YP_002409399.1 CDS hybA NC_011750.1 3648899 3649885 R Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA complement(3648899..3649885) Escherichia coli IAI39 7151704 YP_002409400.1 CDS hybO NC_011750.1 3649888 3651006 R involved in hydrogen uptake; hydrogenase 2 small subunit complement(3649888..3651006) Escherichia coli IAI39 7151703 YP_002409401.1 CDS ECIAI39_3494 NC_011750.1 3651013 3651198 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3651013..3651198) Escherichia coli IAI39 7151710 YP_002409402.1 CDS yghW NC_011750.1 3651195 3651482 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3651195..3651482) Escherichia coli IAI39 7150194 YP_002409403.1 CDS ECIAI39_3496 NC_011750.1 3651601 3652533 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3651601..3652533) Escherichia coli IAI39 7154011 YP_002409404.1 CDS yghZ NC_011750.1 3652645 3653685 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12583903; Product type e : enzyme; aldo-keto reductase 3652645..3653685 Escherichia coli IAI39 7150195 YP_002409405.1 CDS yqhA NC_011750.1 3653725 3654219 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3653725..3654219) Escherichia coli IAI39 7154012 YP_002409406.1 CDS yghA NC_011750.1 3654410 3655294 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; oxidoreductase 3654410..3655294 Escherichia coli IAI39 7154518 YP_002409407.1 CDS exbD NC_011750.1 3655333 3655758 R membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD complement(3655333..3655758) Escherichia coli IAI39 7153997 YP_002409408.1 CDS exbB NC_011750.1 3655765 3656499 R membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB complement(3655765..3656499) Escherichia coli IAI39 7151258 YP_002409409.1 CDS metC NC_011750.1 3656751 3657938 D catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3656751..3657938 Escherichia coli IAI39 7151257 YP_002409410.1 CDS yghB NC_011750.1 3658078 3658737 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3658078..3658737 Escherichia coli IAI39 7152052 YP_002409411.1 CDS yqhC NC_011750.1 3658777 3659733 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3658777..3659733) Escherichia coli IAI39 7153998 YP_002409412.1 CDS yqhD NC_011750.1 3659870 3661033 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15327949; Product type e : enzyme; alcohol dehydrogenase, NAD(P)-dependent 3659870..3661033 Escherichia coli IAI39 7154519 YP_002409413.1 CDS dkgA NC_011750.1 3661138 3661965 D methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3661138..3661965 Escherichia coli IAI39 7154520 YP_002409414.1 CDS yqhG NC_011750.1 3662165 3663091 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3662165..3663091 Escherichia coli IAI39 7151145 YP_002409415.1 CDS yqhH NC_011750.1 3663142 3663399 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative outer membrane lipoprotein 3663142..3663399 Escherichia coli IAI39 7154521 YP_002409416.1 CDS ygiQ NC_011750.1 3663442 3665661 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3663442..3665661) Escherichia coli IAI39 7154522 YP_002409417.1 CDS sufI NC_011750.1 3665772 3667184 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88314889, 1557036, 9298646; Product type r : regulator; repressor protein for FtsI complement(3665772..3667184) Escherichia coli IAI39 7154021 YP_002409418.1 CDS plsC NC_011750.1 3667259 3667996 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92212294, 1557036; Product type e : enzyme; 1-acyl-sn-glycerol-3-phosphate acyltransferase complement(3667259..3667996) Escherichia coli IAI39 7152927 YP_002409419.1 CDS ECIAI39_3512 NC_011750.1 3668044 3668199 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3668044..3668199) Escherichia coli IAI39 7152428 YP_002409420.1 CDS parC NC_011750.1 3668230 3670488 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A complement(3668230..3670488) Escherichia coli IAI39 7150196 YP_002409421.1 CDS ygiS NC_011750.1 3670626 3672233 R YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system; putative binding protein complement(3670626..3672233) Escherichia coli IAI39 7152347 YP_002409422.1 CDS ygiT NC_011750.1 3672366 3672761 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3672366..3672761) Escherichia coli IAI39 7154022 YP_002409423.1 CDS mqsR NC_011750.1 3672763 3673059 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16352847, 12952533, 14727089; Product type r : regulator; motility quorum-sensing regulator complement(3672763..3673059) Escherichia coli IAI39 7154023 YP_002409424.1 CDS ygiV NC_011750.1 3673264 3673746 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator complement(3673264..3673746) Escherichia coli IAI39 7152118 YP_002409425.1 CDS ygiW NC_011750.1 3673799 3674191 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9298646; hypothetical protein complement(3673799..3674191) Escherichia coli IAI39 7154024 YP_002409426.1 CDS qseB NC_011750.1 3674343 3675002 D response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3674343..3675002 Escherichia coli IAI39 7154025 YP_002409427.1 CDS qseC NC_011750.1 3674999 3676348 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21927389; Product type r : regulator; sensor protein QseC 3674999..3676348 Escherichia coli IAI39 7152558 YP_002409428.1 CDS ygiZ NC_011750.1 3676394 3676726 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3676394..3676726) Escherichia coli IAI39 7152559 YP_002409429.1 CDS ECIAI39_3523 NC_011750.1 3676733 3677470 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3676733..3677470) Escherichia coli IAI39 7154026 YP_002409430.1 CDS ECIAI39_3524 NC_011750.1 3677446 3677925 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3677446..3677925) Escherichia coli IAI39 7150197 YP_002409431.1 CDS mdaB NC_011750.1 3678175 3678756 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96004656, 96217538; Product type c : carrier; NADPH quinone reductase 3678175..3678756 Escherichia coli IAI39 7150198 YP_002409432.1 CDS ygiN NC_011750.1 3678787 3679101 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10493123, 9298646, 9600841, 9868784; Product type e : enzyme; quinol monooxygenase 3678787..3679101 Escherichia coli IAI39 7152020 YP_002409433.1 CDS parE NC_011750.1 3679149 3681041 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B complement(3679149..3681041) Escherichia coli IAI39 7154019 YP_002409434.1 CDS yqiA NC_011750.1 3681070 3681651 R Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YqiA complement(3681070..3681651) Escherichia coli IAI39 7152348 YP_002409435.1 CDS cpdA NC_011750.1 3681651 3682478 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96411758; Product type e : enzyme; cyclic 3',5'-adenosine monophosphate phosphodiesterase complement(3681651..3682478) Escherichia coli IAI39 7154523 YP_002409436.1 CDS yqiB NC_011750.1 3682503 3682925 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(3682503..3682925) Escherichia coli IAI39 7150984 YP_002409437.1 CDS nudF NC_011750.1 3682926 3683555 R ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase NudF complement(3682926..3683555) Escherichia coli IAI39 7154524 YP_002409438.1 CDS tolC NC_011750.1 3683760 3685241 D trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3683760..3685241 Escherichia coli IAI39 7152266 YP_002409439.1 CDS ygiB NC_011750.1 3685485 3686060 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3685485..3686060 Escherichia coli IAI39 7152998 YP_002409440.1 CDS ygiC NC_011750.1 3686066 3687226 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3686066..3687226 Escherichia coli IAI39 7154013 YP_002409441.1 CDS zupT NC_011750.1 3687264 3688079 R seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein complement(3687264..3688079) Escherichia coli IAI39 7154014 YP_002409442.1 CDS ygiE NC_011750.1 3688195 3688968 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11790762, 1314093; Product type t : transporter; zinc transporter ZupT 3688195..3688968 Escherichia coli IAI39 7154598 YP_002409443.1 CDS ECIAI39_3537 NC_011750.1 3689026 3689220 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3689026..3689220) Escherichia coli IAI39 7154015 YP_002409444.1 CDS ribB NC_011750.1 3689458 3690111 R DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase complement(3689458..3690111) Escherichia coli IAI39 7150199 YP_002409445.1 CDS yqiC NC_011750.1 3690485 3690775 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3690485..3690775 Escherichia coli IAI39 7150544 YP_002409446.1 CDS ygiL NC_011750.1 3691059 3691610 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial protein 3691059..3691610 Escherichia coli IAI39 7154525 YP_002409447.1 CDS yqiH NC_011750.1 3694190 3694939 D Evidence 2b : Function of strongly homologous gene; Product type f : factor; periplasmic pilin chaperone 3694190..3694939 Escherichia coli IAI39 7154527 YP_002409448.1 CDS yqiI NC_011750.1 3694941 3696005 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3694941..3696005 Escherichia coli IAI39 7154528 YP_002409449.1 CDS glgS NC_011750.1 3696048 3696248 R Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS complement(3696048..3696248) Escherichia coli IAI39 7154529 YP_002409450.1 CDS yqiJ NC_011750.1 3696517 3697146 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3696517..3697146 Escherichia coli IAI39 7151516 YP_002409451.1 CDS yqiK NC_011750.1 3697173 3698834 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3697173..3698834 Escherichia coli IAI39 7154530 YP_002409452.1 CDS rfaE NC_011750.1 3699627 3701060 R catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase complement(3699627..3701060) Escherichia coli IAI39 7150545 YP_002409453.1 CDS glnE NC_011750.1 3701108 3703948 R catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase complement(3701108..3703948) Escherichia coli IAI39 7152601 YP_002409454.1 CDS ygiF NC_011750.1 3703971 3705272 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8412694; Product type pe : putative enzyme; putative adenylate cyclase complement(3703971..3705272) Escherichia coli IAI39 7151526 YP_002409455.1 CDS htrG NC_011750.1 3705514 3706134 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11274153; Product type pr : putative regulator; putative signal transduction protein 3705514..3706134 Escherichia coli IAI39 7154016 YP_002409456.1 CDS cca NC_011750.1 3706198 3707436 D catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3706198..3707436 Escherichia coli IAI39 7151690 YP_002409457.1 CDS bacA NC_011750.1 3707617 3708438 R BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase complement(3707617..3708438) Escherichia coli IAI39 7150908 YP_002409458.1 CDS folB NC_011750.1 3708529 3708897 R catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase complement(3708529..3708897) Escherichia coli IAI39 7150833 YP_002409459.1 CDS plsY NC_011750.1 3709002 3709619 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY 3709002..3709619 Escherichia coli IAI39 7151398 YP_002409460.1 CDS ygiP NC_011750.1 3709632 3710564 R activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol; transcriptional activator TtdR complement(3709632..3710564) Escherichia coli IAI39 7152430 YP_002409461.1 CDS ttdA NC_011750.1 3710771 3711682 D Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 3710771..3711682 Escherichia coli IAI39 7154020 YP_002409462.1 CDS ttdB NC_011750.1 3711679 3712284 D Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 3711679..3712284 Escherichia coli IAI39 7153051 YP_002409463.1 CDS ygjE NC_011750.1 3712333 3713796 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative tartrate:succinate antiporter 3712333..3713796 Escherichia coli IAI39 7153052 YP_002409464.1 CDS gcp NC_011750.1 3713839 3714852 R in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease complement(3713839..3714852) Escherichia coli IAI39 7154027 YP_002409465.1 CDS rpsU NC_011750.1 3715089 3715304 D a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3715089..3715304 Escherichia coli IAI39 7151494 YP_002409466.1 CDS dnaG NC_011750.1 3715415 3717160 D synthesizes RNA primers at the replication forks; DNA primase 3715415..3717160 Escherichia coli IAI39 7152733 YP_002409467.1 CDS rpoD NC_011750.1 3717355 3719196 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3717355..3719196 Escherichia coli IAI39 7151157 YP_002409468.1 CDS insG NC_011750.1 3719334 3720680 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element 3719334..3720680 Escherichia coli IAI39 7152706 YP_002409469.1 CDS ygjF NC_011750.1 3720714 3721220 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20412902, 99453007, 6269063, 7567469, 8878487, 9489705; Product type e : enzyme; G/U mismatch-specific DNA glycosylase complement(3720714..3721220) Escherichia coli IAI39 7151815 YP_002409470.1 CDS yqjH NC_011750.1 3721473 3722237 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative siderophore interacting protein complement(3721473..3722237) Escherichia coli IAI39 7150571 YP_002409471.1 CDS ECIAI39_3567 NC_011750.1 3722449 3722979 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 3722449..3722979 Escherichia coli IAI39 7154539 YP_002409472.1 CDS ECIAI39_3568 NC_011750.1 3723084 3723806 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 3723084..3723806 Escherichia coli IAI39 7150200 YP_002409473.1 CDS yqjI NC_011750.1 3723961 3724584 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 3723961..3724584 Escherichia coli IAI39 7150201 YP_002409474.1 CDS aer NC_011750.1 3724738 3726258 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20015410, 9380671, 9643537, 9190831; Product type r : regulator; fused signal transducer for aerotaxis sensory component ; methyl accepting chemotaxis component complement(3724738..3726258) Escherichia coli IAI39 7154540 YP_002409475.1 CDS ygjG NC_011750.1 3726649 3728055 D catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 3726649..3728055 Escherichia coli IAI39 7150695 YP_002409476.1 CDS ygjH NC_011750.1 3728097 3728429 R Evidence 2b : Function of strongly homologous gene; PubMedId : 11101501; hypothetical protein complement(3728097..3728429) Escherichia coli IAI39 7154029 YP_002409477.1 CDS ebgR NC_011750.1 3728648 3729631 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89128452, 2515108, 3939708; Product type r : regulator; DNA-binding transcriptional repressor EbgR 3728648..3729631 Escherichia coli IAI39 7154030 YP_002409478.1 CDS ebgA NC_011750.1 3729815 3732907 D in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 3729815..3732907 Escherichia coli IAI39 7151197 YP_002409479.1 CDS ebgC NC_011750.1 3732904 3733353 D in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 3732904..3733353 Escherichia coli IAI39 7151195 YP_002409480.1 CDS ygjI NC_011750.1 3733416 3734849 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 3733416..3734849 Escherichia coli IAI39 7151196 YP_002409481.1 CDS ygjJ NC_011750.1 3734983 3736053 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3734983..3736053 Escherichia coli IAI39 7154031 YP_002409482.1 CDS ygjK NC_011750.1 3736070 3738421 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15213393; Product type pe : putative enzyme; putative glycosyl hydrolase 3736070..3738421 Escherichia coli IAI39 7154032 YP_002409483.1 CDS fadH NC_011750.1 3738947 3740965 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12840019, 89380266; Product type e : enzyme; 2,4-dienoyl-CoA reductase, NADH and FMN-linked 3738947..3740965 Escherichia coli IAI39 7154033 YP_002409484.1 CDS ygjO NC_011750.1 3741083 3742219 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase small domain complement(3741083..3742219) Escherichia coli IAI39 7151276 YP_002409485.1 CDS ygjP NC_011750.1 3742304 3742807 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative metal dependent hydrolase 3742304..3742807 Escherichia coli IAI39 7154034 YP_002409486.1 CDS ygjQ NC_011750.1 3742884 3743567 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative thioredoxin-like 3742884..3743567 Escherichia coli IAI39 7154035 YP_002409487.1 CDS ygjR NC_011750.1 3743628 3744632 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative NAD(P)-binding dehydrogenase 3743628..3744632 Escherichia coli IAI39 7154036 YP_002409488.1 CDS alx NC_011750.1 3744915 3745880 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12107143, 2108134; Product type pm : putative membrane component; hypothetical protein 3744915..3745880 Escherichia coli IAI39 7152894 YP_002409489.1 CDS sstT NC_011750.1 3746496 3747740 D involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3746496..3747740 Escherichia coli IAI39 7150724 YP_002409490.1 CDS ygjV NC_011750.1 3747745 3748296 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3747745..3748296) Escherichia coli IAI39 7152910 YP_002409491.1 CDS uxaA NC_011750.1 3748379 3749866 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4570160, 83114543, 3038546; Product type e : enzyme; altronate hydrolase complement(3748379..3749866) Escherichia coli IAI39 7154038 YP_002409492.1 CDS uxaC NC_011750.1 3749881 3751293 R catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase complement(3749881..3751293) Escherichia coli IAI39 7153118 YP_002409493.1 CDS exuT NC_011750.1 3751656 3753074 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83218546, 98190790; Product type t : transporter; hexuronate transporter 3751656..3753074 Escherichia coli IAI39 7153120 YP_002409494.1 CDS ECIAI39_3591 NC_011750.1 3753167 3754255 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative minor pilin and initiator complement(3753167..3754255) Escherichia coli IAI39 7151262 YP_002409495.1 CDS ECIAI39_3592 NC_011750.1 3754252 3756954 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3754252..3756954) Escherichia coli IAI39 7150202 YP_002409496.1 CDS ECIAI39_3593 NC_011750.1 3757027 3757527 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative adhesin major subunit pilin complement(3757027..3757527) Escherichia coli IAI39 7150203 YP_002409497.1 CDS ECIAI39_3594 NC_011750.1 3757557 3758273 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial protein complement(3757557..3758273) Escherichia coli IAI39 7150204 YP_002409498.1 CDS exuR NC_011750.1 3758569 3759345 D regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 3758569..3759345 Escherichia coli IAI39 7150205 YP_002409499.1 CDS yqjA NC_011750.1 3759690 3760352 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3759690..3760352 Escherichia coli IAI39 7151261 YP_002409500.1 CDS yqjB NC_011750.1 3760356 3760739 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3760356..3760739 Escherichia coli IAI39 7154532 YP_002409501.1 CDS yqjC NC_011750.1 3760886 3761254 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3760886..3761254 Escherichia coli IAI39 7154533 YP_002409502.1 CDS yqjD NC_011750.1 3761292 3761597 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3761292..3761597 Escherichia coli IAI39 7154534 YP_002409503.1 CDS yqjE NC_011750.1 3761600 3762004 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3761600..3762004 Escherichia coli IAI39 7154535 YP_002409504.1 CDS yqjK NC_011750.1 3761994 3762293 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3761994..3762293 Escherichia coli IAI39 7154536 YP_002409505.1 CDS yqjF NC_011750.1 3762479 3762871 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative quinol oxidase subunit 3762479..3762871 Escherichia coli IAI39 7154541 YP_002409506.1 CDS yqjG NC_011750.1 3762941 3763927 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8478329; Product type e : enzyme; S-transferase 3762941..3763927 Escherichia coli IAI39 7154537 YP_002409507.1 CDS yhaH NC_011750.1 3764220 3764585 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3764220..3764585 Escherichia coli IAI39 7154538 YP_002409508.1 CDS yhaI NC_011750.1 3764827 3765183 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3764827..3765183 Escherichia coli IAI39 7154041 YP_002409509.1 CDS yhaJ NC_011750.1 3765234 3766130 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3765234..3766130) Escherichia coli IAI39 7154042 YP_002409510.1 CDS yhaK NC_011750.1 3766235 3766936 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative pirin-related protein 3766235..3766936 Escherichia coli IAI39 7154043 YP_002409511.1 CDS yhaL NC_011750.1 3766959 3767123 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3766959..3767123 Escherichia coli IAI39 7154044 YP_002409512.1 CDS ECIAI39_3609 NC_011750.1 3767182 3767904 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group complement(3767182..3767904) Escherichia coli IAI39 7154045 YP_002409513.1 CDS ECIAI39_3610 NC_011750.1 3768009 3768539 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 complement(3768009..3768539) Escherichia coli IAI39 7150206 YP_002409514.1 CDS yhaM NC_011750.1 3768692 3770002 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3768692..3770002) Escherichia coli IAI39 7150207 YP_002409515.1 CDS yhaO NC_011750.1 3770030 3771298 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(3770030..3771298) Escherichia coli IAI39 7154046 YP_002409516.1 CDS tdcG NC_011750.1 3771636 3773000 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98143432, 9484901; Product type e : enzyme; L-serine dehydratase 3 complement(3771636..3773000) Escherichia coli IAI39 7154047 YP_002409517.1 CDS tdcF NC_011750.1 3773072 3773461 R Evidence 2b : Function of strongly homologous gene; PubMedId : 12777779, 9484901; Product type e : enzyme; hypothetical protein complement(3773072..3773461) Escherichia coli IAI39 7152959 YP_002409518.1 CDS tdcE NC_011750.1 3773475 3775769 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98143432, 9484901; Product type e : enzyme; pyruvate formate-lyase 4/2-ketobutyrate formate-lyase complement(3773475..3775769) Escherichia coli IAI39 7152958 YP_002409519.1 CDS tdcD NC_011750.1 3775803 3777023 R catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase complement(3775803..3777023) Escherichia coli IAI39 7152957 YP_002409520.1 CDS tdcC NC_011750.1 3777037 3778368 R involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC complement(3777037..3778368) Escherichia coli IAI39 7152956 YP_002409521.1 CDS tdcB NC_011750.1 3778390 3779379 R catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase complement(3778390..3779379) Escherichia coli IAI39 7152955 YP_002409522.1 CDS tdcA NC_011750.1 3779478 3780416 R regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA complement(3779478..3780416) Escherichia coli IAI39 7152954 YP_002409523.1 CDS tdcR NC_011750.1 3780593 3780949 D participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 3780593..3780949 Escherichia coli IAI39 7152953 YP_002409524.1 CDS yhaB NC_011750.1 3781205 3781744 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3781205..3781744 Escherichia coli IAI39 7152960 YP_002409525.1 CDS yhaC NC_011750.1 3781766 3782953 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1705543, 2573820, 2660107, 6351058; hypothetical protein 3781766..3782953 Escherichia coli IAI39 7154039 YP_002409526.1 CDS garK NC_011750.1 3783469 3784695 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20225875, 69151449, 9772162; Product type e : enzyme; glycerate kinase I complement(3783469..3784695) Escherichia coli IAI39 7150546 YP_002409527.1 CDS garR NC_011750.1 3784711 3785601 R catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase complement(3784711..3785601) Escherichia coli IAI39 7151482 YP_002409528.1 CDS garL NC_011750.1 3785631 3786401 R cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase complement(3785631..3786401) Escherichia coli IAI39 7151485 YP_002409529.1 CDS garP NC_011750.1 3786417 3787751 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10762278, 9772162; Product type pt : putative transporter; putative (D)-galactarate transporter complement(3786417..3787751) Escherichia coli IAI39 7151483 YP_002409530.1 CDS garD NC_011750.1 3788126 3789697 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20225875, 66096392, 81027430, 9772162, 10762278, 2407727; Product type e : enzyme; (D)-galactarate dehydrogenase 3788126..3789697 Escherichia coli IAI39 7151484 YP_002409531.1 CDS sohA NC_011750.1 3789846 3790181 D SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation; putative regulator PrlF 3789846..3790181 Escherichia coli IAI39 7151481 YP_002409532.1 CDS yhaV NC_011750.1 3790181 3790645 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3790181..3790645 Escherichia coli IAI39 7152873 YP_002409533.1 CDS agaR NC_011750.1 3790700 3791509 R transcriptional repressor for the agaZVWA and agaSYBCDI operons; DNA-binding transcriptional regulator AgaR complement(3790700..3791509) Escherichia coli IAI39 7154048 YP_002409534.1 CDS kbaZ NC_011750.1 3791758 3793038 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976750, 20392444, 10931310, 8932697; Product type e : enzyme; tagatose 6-phosphate aldolase 1, kbaZ subunit 3791758..3793038 Escherichia coli IAI39 7150702 YP_002409535.1 CDS agaV NC_011750.1 3793061 3793534 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3793061..3793534 Escherichia coli IAI39 7151874 YP_002409536.1 CDS ECIAI39_3633 NC_011750.1 3793545 3794324 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative enzyme IIC component of PTS 3793545..3794324 Escherichia coli IAI39 7150704 YP_002409537.1 CDS ECIAI39_3634 NC_011750.1 3794308 3795192 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative hexose/hexosamine family PTS permease IID component 3794308..3795192 Escherichia coli IAI39 7150208 YP_002409538.1 CDS ECIAI39_3635 NC_011750.1 3795210 3795644 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system enzyme subunit (N-acetyl-galactosamine / galactosamine PTS system enzyme IIA component) 3795210..3795644 Escherichia coli IAI39 7150209 YP_002409539.1 CDS agaA NC_011750.1 3795620 3796774 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; N-acetylglucosamine-6-phosphate deacetylase 3795620..3796774 Escherichia coli IAI39 7150210 YP_002409540.1 CDS agaS NC_011750.1 3797125 3798279 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689210, 9697096, 14731281, 8932697; Product type e : enzyme; tagatose-6-phosphate ketose/aldose isomerase 3797125..3798279 Escherichia coli IAI39 7150697 YP_002409541.1 CDS kbaY NC_011750.1 3798292 3799152 D catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 3798292..3799152 Escherichia coli IAI39 7150703 YP_002409542.1 CDS agaB NC_011750.1 3799319 3799795 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3799319..3799795 Escherichia coli IAI39 7151873 YP_002409543.1 CDS agaC NC_011750.1 3799834 3800637 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIC 3799834..3800637 Escherichia coli IAI39 7150698 YP_002409544.1 CDS agaD NC_011750.1 3800627 3801418 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IID 3800627..3801418 Escherichia coli IAI39 7150699 YP_002409545.1 CDS agaI NC_011750.1 3801419 3802186 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10931310; Product type e : enzyme; galactosamine-6-phosphate isomerase 3801419..3802186 Escherichia coli IAI39 7150700 YP_002409546.1 CDS yraL NC_011750.1 3802236 3803099 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative methyltransferase complement(3802236..3803099) Escherichia coli IAI39 7150701 YP_002409547.1 CDS yraM NC_011750.1 3803164 3805200 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3803164..3805200 Escherichia coli IAI39 7154542 YP_002409548.1 CDS yraN NC_011750.1 3805158 3805553 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3805158..3805553 Escherichia coli IAI39 7154543 YP_002409549.1 CDS yraO NC_011750.1 3805573 3806163 D Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; DnaA initiator-associating protein DiaA 3805573..3806163 Escherichia coli IAI39 7154544 YP_002409550.1 CDS ecfH NC_011750.1 3806173 3806748 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3806173..3806748 Escherichia coli IAI39 7154545 YP_002409551.1 CDS yraQ NC_011750.1 3806861 3807901 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease complement(3806861..3807901) Escherichia coli IAI39 7151198 YP_002409552.1 CDS yraR NC_011750.1 3807974 3808609 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative nucleoside-diphosphate-sugar epimerase complement(3807974..3808609) Escherichia coli IAI39 7154546 YP_002409553.1 CDS yhbO NC_011750.1 3808737 3809255 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative intracellular protease 3808737..3809255 Escherichia coli IAI39 7154547 YP_002409554.1 CDS yhbP NC_011750.1 3809235 3809678 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3809235..3809678) Escherichia coli IAI39 7154053 YP_002409555.1 CDS yhbQ NC_011750.1 3809729 3810031 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; GIY-YIG nuclease superfamily protein 3809729..3810031 Escherichia coli IAI39 7154054 YP_002409556.1 CDS yhbS NC_011750.1 3810018 3810521 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA N-acyltransferase domain-containing acyltransferase complement(3810018..3810521) Escherichia coli IAI39 7154055 YP_002409557.1 CDS yhbT NC_011750.1 3810515 3811039 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative lipid carrier protein complement(3810515..3811039) Escherichia coli IAI39 7154056 YP_002409558.1 CDS yhbU NC_011750.1 3811248 3812243 D Evidence 2b : Function of strongly homologous gene; PubMedId : 10206698; Product type e : enzyme; collagenase-like peptidase 3811248..3812243 Escherichia coli IAI39 7154057 YP_002409559.1 CDS yhbV NC_011750.1 3812252 3813130 D Evidence 2b : Function of strongly homologous gene; PubMedId : 10206698; Product type e : enzyme; protease 3812252..3813130 Escherichia coli IAI39 7154058 YP_002409560.1 CDS yhbW NC_011750.1 3813211 3814218 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 3813211..3814218 Escherichia coli IAI39 7154059 YP_002409561.1 CDS mtr NC_011750.1 3814337 3815581 R tryptophan transporter of high affinity; tryptophan permease complement(3814337..3815581) Escherichia coli IAI39 7154060 YP_002409562.1 CDS deaD NC_011750.1 3815735 3817624 R participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD complement(3815735..3817624) Escherichia coli IAI39 7152141 YP_002409563.1 CDS nlpI NC_011750.1 3817804 3818688 R lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI complement(3817804..3818688) Escherichia coli IAI39 7151110 YP_002409564.1 CDS pnp NC_011750.1 3818797 3821001 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87083499, 91198209, 99234021, 99340204, 2432069, 3005122, 6382163, 9008164, 9298646; Product type e : enzyme; polynucleotide phosphorylase/polyadenylase complement(3818797..3821001) Escherichia coli IAI39 7152238 YP_002409565.1 CDS rpsO NC_011750.1 3821179 3821448 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(3821179..3821448) Escherichia coli IAI39 7152895 YP_002409566.1 CDS truB NC_011750.1 3821597 3822541 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(3821597..3822541) Escherichia coli IAI39 7152727 YP_002409567.1 CDS rbfA NC_011750.1 3822541 3822942 R associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A complement(3822541..3822942) Escherichia coli IAI39 7153040 YP_002409568.1 CDS infB NC_011750.1 3823106 3825778 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(3823106..3825778) Escherichia coli IAI39 7152569 YP_002409569.1 CDS nusA NC_011750.1 3825803 3827290 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(3825803..3827290) Escherichia coli IAI39 7151778 YP_002409570.1 CDS yhbC NC_011750.1 3827318 3827770 R in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein complement(3827318..3827770) Escherichia coli IAI39 7152284 YP_002409571.1 CDS argG NC_011750.1 3828401 3829744 D catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 3828401..3829744 Escherichia coli IAI39 7150594 YP_002409572.1 CDS yhbX NC_011750.1 3829752 3831377 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase, inner membrane complement(3829752..3831377) Escherichia coli IAI39 7150765 YP_002409573.1 CDS secG NC_011750.1 3831937 3832269 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20194819, 21125563, 9020118, 94074540, 9564033, 9644254, 9829959, 99298179, 7556084, 8034620, 8045257, 8244950, 8253068; Product type t : transporter; preprotein translocase subunit SecG complement(3831937..3832269) Escherichia coli IAI39 7150593 YP_002409574.1 CDS glmM NC_011750.1 3832497 3833834 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(3832497..3833834) Escherichia coli IAI39 7152823 YP_002409575.1 CDS folP NC_011750.1 3833827 3834675 R catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase complement(3833827..3834675) Escherichia coli IAI39 7151520 YP_002409576.1 CDS hflB NC_011750.1 3834765 3836699 R inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease complement(3834765..3836699) Escherichia coli IAI39 7151404 YP_002409577.1 CDS rrmJ NC_011750.1 3836799 3837428 R Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase J complement(3836799..3837428) Escherichia coli IAI39 7151436 YP_002409578.1 CDS yhbY NC_011750.1 3837554 3837847 D RNA binding protein found associated to pre-50S subunit of the ribosome; putative role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 3837554..3837847 Escherichia coli IAI39 7152736 YP_002409579.1 CDS greA NC_011750.1 3838003 3838479 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(3838003..3838479) Escherichia coli IAI39 7154062 YP_002409580.1 CDS dacB NC_011750.1 3838727 3840160 D penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase/endopeptidase 3838727..3840160 Escherichia coli IAI39 7151583 YP_002409581.1 CDS obgE NC_011750.1 3840201 3841373 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(3840201..3841373) Escherichia coli IAI39 7151077 YP_002409582.1 CDS yhbE NC_011750.1 3841389 3842354 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(3841389..3842354) Escherichia coli IAI39 7152288 YP_002409583.1 CDS rpmA NC_011750.1 3842481 3842738 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(3842481..3842738) Escherichia coli IAI39 7154050 YP_002409584.1 CDS rplU NC_011750.1 3842759 3843070 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91088242, 94146411, 10094780, 387076, 8312607; Product type s : structure; 50S ribosomal protein L21 complement(3842759..3843070) Escherichia coli IAI39 7152694 YP_002409585.1 CDS ispB NC_011750.1 3843329 3844300 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94311902, 97284515, 2670911, 8037730, 8312607; Product type e : enzyme; octaprenyl diphosphate synthase 3843329..3844300 Escherichia coli IAI39 7152689 YP_002409586.1 CDS sfsB NC_011750.1 3844528 3844806 D activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 3844528..3844806 Escherichia coli IAI39 7151852 YP_002409587.1 CDS murA NC_011750.1 3844854 3846113 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(3844854..3846113) Escherichia coli IAI39 7152843 YP_002409588.1 CDS yrbA NC_011750.1 3846168 3846422 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3846168..3846422) Escherichia coli IAI39 7152145 YP_002409589.1 CDS yrbB NC_011750.1 3846582 3846875 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3846582..3846875) Escherichia coli IAI39 7154548 YP_002409590.1 CDS yrbC NC_011750.1 3846875 3847510 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene ABC transporter membrane protein complement(3846875..3847510) Escherichia coli IAI39 7154549 YP_002409591.1 CDS yrbD NC_011750.1 3847529 3848080 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene ABC transporter membrane protein complement(3847529..3848080) Escherichia coli IAI39 7154550 YP_002409592.1 CDS yrbE NC_011750.1 3848085 3848867 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene ABC transporter membrane protein complement(3848085..3848867) Escherichia coli IAI39 7154551 YP_002409593.1 CDS yrbF NC_011750.1 3848875 3849684 R ATP-binding subunit of a putative ABC toluene efflux transporter; putative ABC transporter ATP-binding protein YrbF complement(3848875..3849684) Escherichia coli IAI39 7154552 YP_002409594.1 CDS yrbG NC_011750.1 3849894 3850871 D YrbG; inner membrane protein involved in cell envelope integrity; putative sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; putative calcium/sodium:proton antiporter 3849894..3850871 Escherichia coli IAI39 7154553 YP_002409595.1 CDS kdsD NC_011750.1 3850885 3851871 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12805358; Product type e : enzyme; D-arabinose 5-phosphate isomerase 3850885..3851871 Escherichia coli IAI39 7154554 YP_002409596.1 CDS kdsC NC_011750.1 3851892 3852458 D forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 3851892..3852458 Escherichia coli IAI39 7151888 YP_002409597.1 CDS yrbK NC_011750.1 3852455 3853030 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3852455..3853030 Escherichia coli IAI39 7151887 YP_002409598.1 CDS lptA NC_011750.1 3852999 3853556 D LptA; periplasmic binding protein part of a putative ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 3852999..3853556 Escherichia coli IAI39 7154555 YP_002409599.1 CDS lptB NC_011750.1 3853563 3854288 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7876255, 9298646, 17056748; Product type pt : putative transporter; putative ABC transporter ATP-binding protein YhbG 3853563..3854288 Escherichia coli IAI39 7151963 YP_002409600.1 CDS rpoN NC_011750.1 3854336 3855769 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 3854336..3855769 Escherichia coli IAI39 7151964 YP_002409601.1 CDS yhbH NC_011750.1 3855792 3856079 D YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; putative sigma(54) modulation protein 3855792..3856079 Escherichia coli IAI39 7152709 YP_002409602.1 CDS ptsN NC_011750.1 3856197 3856688 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88212176, 90136533, 90274974, 95020584, 95181483, 7876255, 8025669, 8444818, 9636714; Product type t : transporter; PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN 3856197..3856688 Escherichia coli IAI39 7154051 YP_002409603.1 CDS yhbJ NC_011750.1 3856734 3857588 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3856734..3857588 Escherichia coli IAI39 7152521 YP_002409604.1 CDS npr NC_011750.1 3857585 3857857 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10473571, 95181483, 7876255, 8025669; Product type t : transporter; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 3857585..3857857 Escherichia coli IAI39 7154052 YP_002409605.1 CDS yrbL NC_011750.1 3858070 3858702 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 89083480; hypothetical protein 3858070..3858702 Escherichia coli IAI39 7152243 YP_002409606.1 CDS mtgA NC_011750.1 3858699 3859427 R glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase complement(3858699..3859427) Escherichia coli IAI39 7154556 YP_002409607.1 CDS elbB NC_011750.1 3859424 3860077 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92246944, 98269038, 1575737, 9603997; Product type pe : putative enzyme; isoprenoid biosynthesis protein complement(3859424..3860077) Escherichia coli IAI39 7152137 YP_002409608.1 CDS arcB NC_011750.1 3860307 3862643 R sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB complement(3860307..3862643) Escherichia coli IAI39 7152791 YP_002409609.1 CDS yhcC NC_011750.1 3862739 3863668 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Fe-S oxidoreductase complement(3862739..3863668) Escherichia coli IAI39 7150757 YP_002409610.1 CDS gltB NC_011750.1 3864250 3868803 D catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase subunit alpha 3864250..3868803 Escherichia coli IAI39 7154064 YP_002409611.1 CDS gltD NC_011750.1 3868816 3870234 D glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 3868816..3870234 Escherichia coli IAI39 7151549 YP_002409612.1 CDS yhcG NC_011750.1 3870403 3871530 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3870403..3871530 Escherichia coli IAI39 7151550 YP_002409613.1 CDS yhcH NC_011750.1 3871590 3872054 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3871590..3872054) Escherichia coli IAI39 7154065 YP_002409614.1 CDS nanK NC_011750.1 3872051 3872926 R catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase complement(3872051..3872926) Escherichia coli IAI39 7154066 YP_002409615.1 CDS nanE NC_011750.1 3872923 3873612 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(3872923..3873612) Escherichia coli IAI39 7152179 YP_002409616.1 CDS nanT NC_011750.1 3873660 3875150 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96011396, 9864311, 7592358; Product type t : transporter; putative sialic acid transporter complement(3873660..3875150) Escherichia coli IAI39 7152178 YP_002409617.1 CDS nanA NC_011750.1 3875259 3876152 R catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase complement(3875259..3876152) Escherichia coli IAI39 7152181 YP_002409618.1 CDS nanR NC_011750.1 3876274 3877065 R Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR complement(3876274..3877065) Escherichia coli IAI39 7152177 YP_002409619.1 CDS dcuD NC_011750.1 3877445 3878812 D YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic; putative cryptic C4-dicarboxylate transporter DcuD 3877445..3878812 Escherichia coli IAI39 7152180 YP_002409620.1 CDS sspB NC_011750.1 3878856 3879353 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12445774, 94293773, 1721886, 3029697, 8022275; Product type f : factor; ClpXP protease specificity-enhancing factor complement(3878856..3879353) Escherichia coli IAI39 7151098 YP_002409621.1 CDS sspA NC_011750.1 3879359 3879997 R transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A complement(3879359..3879997) Escherichia coli IAI39 7152907 YP_002409622.1 CDS ECIAI39_3719 NC_011750.1 3880267 3881061 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3880267..3881061) Escherichia coli IAI39 7152906 YP_002409623.1 CDS rpsI NC_011750.1 3881216 3881608 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(3881216..3881608) Escherichia coli IAI39 7150211 YP_002409624.1 CDS rplM NC_011750.1 3881624 3882052 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(3881624..3882052) Escherichia coli IAI39 7152721 YP_002409625.1 CDS yhcM NC_011750.1 3882271 3883398 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3882271..3883398) Escherichia coli IAI39 7152681 YP_002409626.1 CDS yhcB NC_011750.1 3883592 3883990 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16079137; Product type pe : putative enzyme; cytochrome d ubiquinol oxidase subunit III 3883592..3883990 Escherichia coli IAI39 7154067 YP_002409627.1 CDS degQ NC_011750.1 3884144 3885511 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8830688, 96165272, 8576051, 8576052, 9740056; Product type e : enzyme; serine endoprotease 3884144..3885511 Escherichia coli IAI39 7154063 YP_002409628.1 CDS degS NC_011750.1 3885601 3886668 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15137941, 15225661, 21352996, 96165272, 99431977, 3322223, 8576051; Product type e : enzyme; serine endoprotease 3885601..3886668 Escherichia coli IAI39 7151115 YP_002409629.1 CDS insG NC_011750.1 3886772 3888118 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element 3886772..3888118 Escherichia coli IAI39 7151116 YP_002409630.1 CDS mdh NC_011750.1 3888169 3889107 R oxidizes malate to oxaloacetate; malate dehydrogenase complement(3888169..3889107) Escherichia coli IAI39 7151816 YP_002409631.1 CDS argR NC_011750.1 3889542 3890012 D regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 3889542..3890012 Escherichia coli IAI39 7152021 YP_002409632.1 CDS yhcN NC_011750.1 3890376 3890639 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3890376..3890639 Escherichia coli IAI39 7150771 YP_002409633.1 CDS yhcO NC_011750.1 3890696 3890968 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative barnase inhibitor complement(3890696..3890968) Escherichia coli IAI39 7154068 YP_002409634.1 CDS aaeB NC_011750.1 3891060 3893027 R with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB complement(3891060..3893027) Escherichia coli IAI39 7154069 YP_002409635.1 CDS aaeA NC_011750.1 3893033 3893965 R with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA complement(3893033..3893965) Escherichia coli IAI39 7150641 YP_002409636.1 CDS aaeX NC_011750.1 3893973 3894176 R membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein complement(3893973..3894176) Escherichia coli IAI39 7150640 YP_002409637.1 CDS aaeR NC_011750.1 3894359 3895288 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15489430; Product type r : regulator; putative DNA-binding transcriptional regulator 3894359..3895288 Escherichia coli IAI39 7150643 YP_002409638.1 CDS tldD NC_011750.1 3895416 3896861 R responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD complement(3895416..3896861) Escherichia coli IAI39 7150642 YP_002409639.1 CDS ECIAI39_3736 NC_011750.1 3896959 3897681 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group complement(3896959..3897681) Escherichia coli IAI39 7152991 YP_002409640.1 CDS ECIAI39_3737 NC_011750.1 3897786 3898316 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 complement(3897786..3898316) Escherichia coli IAI39 7150212 YP_002409641.1 CDS yhdP NC_011750.1 3898452 3902252 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10960106; Product type pm : putative membrane component; hypothetical protein complement(3898452..3902252) Escherichia coli IAI39 7150213 YP_002409642.1 CDS rng NC_011750.1 3902320 3903789 R involved in the processing of the 5'end of 16S rRNA; ribonuclease G complement(3902320..3903789) Escherichia coli IAI39 7154075 YP_002409643.1 CDS yhdE NC_011750.1 3903779 3904372 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(3903779..3904372) Escherichia coli IAI39 7152657 YP_002409644.1 CDS mreD NC_011750.1 3904381 3904869 R part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD complement(3904381..3904869) Escherichia coli IAI39 7154070 YP_002409645.1 CDS mreC NC_011750.1 3904869 3905972 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(3904869..3905972) Escherichia coli IAI39 7152128 YP_002409646.1 CDS mreB NC_011750.1 3906038 3907081 R functions in MreBCD complex in some organisms; rod shape-determining protein MreB complement(3906038..3907081) Escherichia coli IAI39 7152127 YP_002409647.1 CDS csrD NC_011750.1 3907386 3909326 R regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD complement(3907386..3909326) Escherichia coli IAI39 7152126 YP_002409648.1 CDS yhdH NC_011750.1 3909478 3910452 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 3909478..3910452 Escherichia coli IAI39 7151024 YP_002409649.1 CDS accB NC_011750.1 3911430 3911900 D composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3911430..3911900 Escherichia coli IAI39 7154071 YP_002409650.1 CDS accC NC_011750.1 3911911 3913260 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 3911911..3913260 Escherichia coli IAI39 7150657 YP_002409651.1 CDS ECIAI39_3749 NC_011750.1 3913352 3914398 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3913352..3914398) Escherichia coli IAI39 7150658 YP_002409652.1 CDS ECIAI39_3750 NC_011750.1 3914395 3915357 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative carbohydrate kinase complement(3914395..3915357) Escherichia coli IAI39 7150214 YP_002409653.1 CDS ECIAI39_3751 NC_011750.1 3915379 3916368 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter membrane protein complement(3915379..3916368) Escherichia coli IAI39 7150215 YP_002409654.1 CDS ECIAI39_3752 NC_011750.1 3916369 3917868 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter ATP-binding protein complement(3916369..3917868) Escherichia coli IAI39 7150216 YP_002409655.1 CDS ECIAI39_3753 NC_011750.1 3917929 3918825 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC-type sugar transport system, periplasmic component complement(3917929..3918825) Escherichia coli IAI39 7150217 YP_002409656.1 CDS gatY NC_011750.1 3918855 3919709 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase complement(3918855..3919709) Escherichia coli IAI39 7150218 YP_002409657.1 CDS ECIAI39_3755 NC_011750.1 3920051 3920881 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DEOR-type transcriptional regulator 3920051..3920881 Escherichia coli IAI39 7150219 YP_002409658.1 CDS ECIAI39_3756 NC_011750.1 3920838 3921848 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative pfkB family carbohydrate kinase 3920838..3921848 Escherichia coli IAI39 7150220 YP_002409659.1 CDS yhdT NC_011750.1 3921942 3922184 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3921942..3922184 Escherichia coli IAI39 7150221 YP_002409660.1 CDS panF NC_011750.1 3922174 3923625 D mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 3922174..3923625 Escherichia coli IAI39 7154076 YP_002409661.1 CDS prmA NC_011750.1 3923637 3924518 D methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 3923637..3924518 Escherichia coli IAI39 7152327 YP_002409662.1 CDS dusB NC_011750.1 3924847 3925812 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566, 1459953, 1547773, 2835774, 2837762, 8226664; Product type e : enzyme; tRNA-dihydrouridine synthase B 3924847..3925812 Escherichia coli IAI39 7152480 YP_002409663.1 CDS fis NC_011750.1 3925838 3926134 D Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 3925838..3926134 Escherichia coli IAI39 7151186 YP_002409664.1 CDS yhdJ NC_011750.1 3926220 3927104 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15028690, 9073062; Product type e : enzyme; putative methyltransferase 3926220..3927104 Escherichia coli IAI39 7151338 YP_002409665.1 CDS yhdU NC_011750.1 3927188 3927367 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3927188..3927367 Escherichia coli IAI39 7154072 YP_002409666.1 CDS envR NC_011750.1 3927370 3928032 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8203018, 11257026, 8407802, 1720861; Product type r : regulator; DNA-binding transcriptional regulator EnvR complement(3927370..3928032) Escherichia coli IAI39 7154077 YP_002409667.1 CDS acrE NC_011750.1 3928431 3929588 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012493, 1720861; Product type lp : lipoprotein; cytoplasmic membrane lipoprotein 3928431..3929588 Escherichia coli IAI39 7151229 YP_002409668.1 CDS yhdV NC_011750.1 3932926 3933147 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3932926..3933147 Escherichia coli IAI39 7150678 YP_002409669.1 CDS aapJ NC_011750.1 3933686 3934603 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid ABC transporter periplasmic-binding protein 3933686..3934603 Escherichia coli IAI39 7154078 YP_002409670.1 CDS aapQ NC_011750.1 3934671 3935852 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid ABC transporter membrane protein 3934671..3935852 Escherichia coli IAI39 7150644 YP_002409671.1 CDS aapM NC_011750.1 3935862 3936965 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid ABC transporter membrane protein 3935862..3936965 Escherichia coli IAI39 7150647 YP_002409672.1 CDS aapP NC_011750.1 3936973 3937731 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8809753, 8898392; Product type t : transporter; amino-acid ABC transporter ATP-binding protein 3936973..3937731 Escherichia coli IAI39 7150645 YP_002409673.1 CDS yrdA NC_011750.1 3943284 3944165 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3943284..3944165 Escherichia coli IAI39 7149774 YP_002409674.1 CDS aroE NC_011750.1 3944395 3945213 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(3944395..3945213) Escherichia coli IAI39 7154557 YP_002409675.1 CDS yrdC NC_011750.1 3945218 3945790 R RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; putative ribosome maturation factor complement(3945218..3945790) Escherichia coli IAI39 7150779 YP_002409676.1 CDS yrdD NC_011750.1 3945795 3946337 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative DNA topoisomerase complement(3945795..3946337) Escherichia coli IAI39 7154558 YP_002409677.1 CDS smg NC_011750.1 3946366 3946839 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8432722; hypothetical protein complement(3946366..3946839) Escherichia coli IAI39 7154559 YP_002409678.1 CDS def NC_011750.1 3948065 3948574 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 3948065..3948574 Escherichia coli IAI39 7152865 YP_002409679.1 CDS fmt NC_011750.1 3948589 3949536 D modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 3948589..3949536 Escherichia coli IAI39 7151113 YP_002409680.1 CDS rsmB NC_011750.1 3949582 3950871 D catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase B 3949582..3950871 Escherichia coli IAI39 7151393 YP_002409681.1 CDS trkA NC_011750.1 3950893 3952269 D involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 3950893..3952269 Escherichia coli IAI39 7152743 YP_002409682.1 CDS mscL NC_011750.1 3952399 3952809 D forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 3952399..3952809 Escherichia coli IAI39 7153022 YP_002409683.1 CDS yhdL NC_011750.1 3952806 3953024 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3952806..3953024) Escherichia coli IAI39 7152132 YP_002409684.1 CDS zntR NC_011750.1 3953080 3953505 R mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator complement(3953080..3953505) Escherichia coli IAI39 7154073 YP_002409685.1 CDS yhdN NC_011750.1 3953516 3953884 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3953516..3953884) Escherichia coli IAI39 7154591 YP_002409686.1 CDS rplQ NC_011750.1 3953991 3954374 R is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 complement(3953991..3954374) Escherichia coli IAI39 7154074 YP_002409687.1 CDS rpoA NC_011750.1 3954415 3955404 R catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha complement(3954415..3955404) Escherichia coli IAI39 7152685 YP_002409688.1 CDS rpsD NC_011750.1 3955430 3956050 R primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 complement(3955430..3956050) Escherichia coli IAI39 7152703 YP_002409689.1 CDS rpsK NC_011750.1 3956084 3956473 R located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 complement(3956084..3956473) Escherichia coli IAI39 7152716 YP_002409690.1 CDS rpsM NC_011750.1 3956490 3956846 R located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 complement(3956490..3956846) Escherichia coli IAI39 7152723 YP_002409691.1 CDS secY NC_011750.1 3957141 3958472 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(3957141..3958472) Escherichia coli IAI39 7150547 YP_002409692.1 CDS rplO NC_011750.1 3958480 3958914 R late assembly protein; 50S ribosomal protein L15 complement(3958480..3958914) Escherichia coli IAI39 7152825 YP_002409693.1 CDS rpmD NC_011750.1 3958918 3959097 R L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 complement(3958918..3959097) Escherichia coli IAI39 7152683 YP_002409694.1 CDS rpsE NC_011750.1 3959101 3959604 R located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 complement(3959101..3959604) Escherichia coli IAI39 7152697 YP_002409695.1 CDS rplR NC_011750.1 3959619 3959972 R binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 complement(3959619..3959972) Escherichia coli IAI39 7152717 YP_002409696.1 CDS rplF NC_011750.1 3959982 3960515 R ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 complement(3959982..3960515) Escherichia coli IAI39 7152686 YP_002409697.1 CDS rpsH NC_011750.1 3960528 3960920 R binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 complement(3960528..3960920) Escherichia coli IAI39 7152676 YP_002409698.1 CDS rpsN NC_011750.1 3960954 3961259 R located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 complement(3960954..3961259) Escherichia coli IAI39 7152720 YP_002409699.1 CDS rplE NC_011750.1 3961274 3961813 R part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 complement(3961274..3961813) Escherichia coli IAI39 7152726 YP_002409700.1 CDS rplX NC_011750.1 3961828 3962142 R assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 complement(3961828..3962142) Escherichia coli IAI39 7152675 YP_002409701.1 CDS rplN NC_011750.1 3962153 3962524 R binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 complement(3962153..3962524) Escherichia coli IAI39 7152692 YP_002409702.1 CDS rpsQ NC_011750.1 3962689 3962943 R primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 complement(3962689..3962943) Escherichia coli IAI39 7152682 YP_002409703.1 CDS rpmC NC_011750.1 3962943 3963134 R one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 complement(3962943..3963134) Escherichia coli IAI39 7152729 YP_002409704.1 CDS rplP NC_011750.1 3963134 3963544 R located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 complement(3963134..3963544) Escherichia coli IAI39 7152696 YP_002409705.1 CDS rpsC NC_011750.1 3963557 3964258 R forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 complement(3963557..3964258) Escherichia coli IAI39 7152684 YP_002409706.1 CDS rplV NC_011750.1 3964276 3964608 R binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 complement(3964276..3964608) Escherichia coli IAI39 7152715 YP_002409707.1 CDS rpsS NC_011750.1 3964623 3964901 R protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 complement(3964623..3964901) Escherichia coli IAI39 7152690 YP_002409708.1 CDS rplB NC_011750.1 3964918 3965739 R one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 complement(3964918..3965739) Escherichia coli IAI39 7152731 YP_002409709.1 CDS rplW NC_011750.1 3965757 3966059 R binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 complement(3965757..3966059) Escherichia coli IAI39 7152672 YP_002409710.1 CDS rplD NC_011750.1 3966056 3966661 R L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 complement(3966056..3966661) Escherichia coli IAI39 7152691 YP_002409711.1 CDS rplC NC_011750.1 3966672 3967301 R binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 complement(3966672..3967301) Escherichia coli IAI39 7152674 YP_002409712.1 CDS rpsJ NC_011750.1 3967334 3967645 R NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 complement(3967334..3967645) Escherichia coli IAI39 7152673 YP_002409713.1 CDS ECIAI39_3816 NC_011750.1 3968103 3968492 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative bifunctional prepilin peptidase HopD: leader peptidase; methyl transferase (General Secretory Pathway) 3968103..3968492 Escherichia coli IAI39 7152722 YP_002409714.1 CDS bfr NC_011750.1 3968489 3968965 R iron storage protein; bacterioferritin complement(3968489..3968965) Escherichia coli IAI39 7150222 YP_002409715.1 CDS bfd NC_011750.1 3969038 3969232 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8954950, 9889981, 2661540, 8639572; Product type c : carrier; bacterioferritin-associated ferredoxin complement(3969038..3969232) Escherichia coli IAI39 7150858 YP_002409716.1 CDS tufA NC_011750.1 3969415 3970599 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(3969415..3970599) Escherichia coli IAI39 7150857 YP_002409717.1 CDS fusA NC_011750.1 3970670 3972784 R EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G complement(3970670..3972784) Escherichia coli IAI39 7153054 YP_002409718.1 CDS rpsG NC_011750.1 3972881 3973351 R binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 complement(3972881..3973351) Escherichia coli IAI39 7151457 YP_002409719.1 CDS rpsL NC_011750.1 3973448 3973822 R interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 complement(3973448..3973822) Escherichia coli IAI39 7152719 YP_002409720.1 CDS tusB NC_011750.1 3973948 3974235 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB complement(3973948..3974235) Escherichia coli IAI39 7152724 YP_002409721.1 CDS tusC NC_011750.1 3974243 3974602 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC complement(3974243..3974602) Escherichia coli IAI39 7153058 YP_002409722.1 CDS tusD NC_011750.1 3974602 3974988 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD complement(3974602..3974988) Escherichia coli IAI39 7153059 YP_002409723.1 CDS yheO NC_011750.1 3974988 3975710 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(3974988..3975710) Escherichia coli IAI39 7153060 YP_002409724.1 CDS fkpA NC_011750.1 3975877 3976689 R rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase complement(3975877..3976689) Escherichia coli IAI39 7154079 YP_002409725.1 CDS slyX NC_011750.1 3976910 3977128 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3976910..3977128 Escherichia coli IAI39 7151345 YP_002409726.1 CDS slyD NC_011750.1 3977178 3977768 R rotamase; FKBP-type peptidyl-prolyl cis-trans isomerase complement(3977178..3977768) Escherichia coli IAI39 7152863 YP_002409727.1 CDS yheV NC_011750.1 3977863 3978063 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3977863..3978063) Escherichia coli IAI39 7152862 YP_002409728.1 CDS kefG NC_011750.1 3979878 3980432 R required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG complement(3979878..3980432) Escherichia coli IAI39 7151894 YP_002409729.1 CDS yheS NC_011750.1 3980560 3982473 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter ATP-binding protein 3980560..3982473 Escherichia coli IAI39 7151897 YP_002409730.1 CDS yheT NC_011750.1 3982473 3983495 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9889164; Product type pe : putative enzyme; putative hydrolase 3982473..3983495 Escherichia coli IAI39 7154080 YP_002409731.1 CDS yheU NC_011750.1 3983489 3983707 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3983489..3983707 Escherichia coli IAI39 7154081 YP_002409732.1 CDS prkB NC_011750.1 3983761 3984630 D Evidence 2b : Function of strongly homologous gene; PubMedId : 2559876; Product type e : enzyme; phosphoribulokinase 3983761..3984630 Escherichia coli IAI39 7154082 YP_002409733.1 CDS yhfA NC_011750.1 3984685 3985089 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3984685..3985089) Escherichia coli IAI39 7152478 YP_002409734.1 CDS ECIAI39_3840 NC_011750.1 3985169 3985384 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3985169..3985384 Escherichia coli IAI39 7151000 YP_002409735.1 CDS crp NC_011750.1 3985391 3986023 D complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 3985391..3986023 Escherichia coli IAI39 7150223 YP_002409736.1 CDS yhfK NC_011750.1 3986062 3988164 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 3986062..3988164 Escherichia coli IAI39 7150999 YP_002409737.1 CDS argD NC_011750.1 3988227 3989450 R DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein complement(3988227..3989450) Escherichia coli IAI39 7154086 YP_002409738.1 CDS pabA NC_011750.1 3989535 3990098 R aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II complement(3989535..3990098) Escherichia coli IAI39 7150763 YP_002409739.1 CDS fic NC_011750.1 3990130 3990732 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92021789, 94095125, 2007139, 2403545, 2546924, 7549107; Product type cp : cell process; cell filamentation protein Fic complement(3990130..3990732) Escherichia coli IAI39 7152319 YP_002409740.1 CDS yhfG NC_011750.1 3990722 3990889 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3990722..3990889) Escherichia coli IAI39 7151324 YP_002409741.1 CDS ppiA NC_011750.1 3990994 3991566 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90272647, 91175755, 1606970, 2001362, 2007139, 2190212, 2403545, 2546924, 8130188, 8180197; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase A complement(3990994..3991566) Escherichia coli IAI39 7154085 YP_002409742.1 CDS tsgA NC_011750.1 3991837 3993018 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20509826; Product type pt : putative transporter; hypothetical protein 3991837..3993018 Escherichia coli IAI39 7152460 YP_002409743.1 CDS nirB NC_011750.1 3993280 3995823 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93062014, 2200672, 2445993, 2543955; Product type e : enzyme; nitrite reductase, large subunit, NAD(P) H-binding 3993280..3995823 Escherichia coli IAI39 7153047 YP_002409744.1 CDS nirD NC_011750.1 3995820 3996146 D involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 3995820..3996146 Escherichia coli IAI39 7152230 YP_002409745.1 CDS nirC NC_011750.1 3996272 3997078 D member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 3996272..3997078 Escherichia coli IAI39 7152232 YP_002409746.1 CDS cysG NC_011750.1 3997097 3998470 D multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 3997097..3998470 Escherichia coli IAI39 7152231 YP_002409747.1 CDS yhfL NC_011750.1 3998721 3998888 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3998721..3998888 Escherichia coli IAI39 7151060 YP_002409748.1 CDS yhfS NC_011750.1 3998995 4000080 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3998995..4000080) Escherichia coli IAI39 7154087 YP_002409749.1 CDS yhfT NC_011750.1 4000092 4001396 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4000092..4001396) Escherichia coli IAI39 7154088 YP_002409750.1 CDS yhfU NC_011750.1 4001408 4001761 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4001408..4001761) Escherichia coli IAI39 7154089 YP_002409751.1 CDS php NC_011750.1 4001772 4002650 R phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE); putative hydrolase complement(4001772..4002650) Escherichia coli IAI39 7154090 YP_002409752.1 CDS yhfW NC_011750.1 4002647 4003873 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative mutase complement(4002647..4003873) Escherichia coli IAI39 7152417 YP_002409753.1 CDS yhfX NC_011750.1 4003873 4005036 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative amino acid racemase complement(4003873..4005036) Escherichia coli IAI39 7154091 YP_002409754.1 CDS yhfY NC_011750.1 4005120 4005482 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4005120..4005482) Escherichia coli IAI39 7154092 YP_002409755.1 CDS yhfZ NC_011750.1 4005499 4006404 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4005499..4006404) Escherichia coli IAI39 7154093 YP_002409756.1 CDS trpS NC_011750.1 4006564 4007568 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase complement(4006564..4007568) Escherichia coli IAI39 7154094 YP_002409757.1 CDS gph NC_011750.1 4007561 4008319 R catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase complement(4007561..4008319) Escherichia coli IAI39 7153038 YP_002409758.1 CDS rpe NC_011750.1 4008312 4008989 R catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase complement(4008312..4008989) Escherichia coli IAI39 7151577 YP_002409759.1 CDS dam NC_011750.1 4009007 4009843 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90136529, 92262475, 92272672, 2549371, 6300769, 7603433, 8341592; Product type e : enzyme; DNA adenine methylase complement(4009007..4009843) Escherichia coli IAI39 7152666 YP_002409760.1 CDS damX NC_011750.1 4009950 4011236 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4009950..4011236) Escherichia coli IAI39 7151082 YP_002409761.1 CDS aroB NC_011750.1 4011328 4012416 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(4011328..4012416) Escherichia coli IAI39 7151083 YP_002409762.1 CDS aroK NC_011750.1 4012473 4012994 R type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I complement(4012473..4012994) Escherichia coli IAI39 7150776 YP_002409763.1 CDS hofQ NC_011750.1 4013395 4014633 R outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; outer membrane porin HofQ complement(4013395..4014633) Escherichia coli IAI39 7150783 YP_002409764.1 CDS yrfA NC_011750.1 4014545 4014949 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4014545..4014949) Escherichia coli IAI39 7151666 YP_002409765.1 CDS yrfB NC_011750.1 4014939 4015379 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4014939..4015379) Escherichia coli IAI39 7154560 YP_002409766.1 CDS yrfC NC_011750.1 4015363 4015902 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative fimbrial assembly protein (pilN-like) complement(4015363..4015902) Escherichia coli IAI39 7154561 YP_002409767.1 CDS yrfD NC_011750.1 4015902 4016681 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative pilus assembly protein complement(4015902..4016681) Escherichia coli IAI39 7154562 YP_002409768.1 CDS mrcA NC_011750.1 4016801 4019353 D bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 4016801..4019353 Escherichia coli IAI39 7154563 YP_002409769.1 CDS nudE NC_011750.1 4019522 4020082 R ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE complement(4019522..4020082) Escherichia coli IAI39 7152122 YP_002409770.1 CDS igaA NC_011750.1 4020402 4022537 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11553591; Product type r : regulator; intracellular growth attenuator protein 4020402..4022537 Escherichia coli IAI39 7152265 YP_002409771.1 CDS yrfG NC_011750.1 4022602 4023270 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hydrolase 4022602..4023270 Escherichia coli IAI39 7151759 YP_002409772.1 CDS hslR NC_011750.1 4023281 4023682 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9867837, 10675343, 10675344; Product type f : factor; ribosome-associated heat shock protein Hsp15 4023281..4023682 Escherichia coli IAI39 7154564 YP_002409773.1 CDS hslO NC_011750.1 4023707 4024585 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 4023707..4024585 Escherichia coli IAI39 7151682 YP_002409774.1 CDS yhgE NC_011750.1 4024719 4026443 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 20223645; Product type pm : putative membrane component; hypothetical protein complement(4024719..4026443) Escherichia coli IAI39 7151681 YP_002409775.1 CDS pck NC_011750.1 4026822 4028444 D PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 4026822..4028444 Escherichia coli IAI39 7154096 YP_002409776.1 CDS ECIAI39_3882 NC_011750.1 4028559 4028876 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4028559..4028876 Escherichia coli IAI39 7152351 YP_002409777.1 CDS ECIAI39_3883 NC_011750.1 4028935 4029231 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2404279; Product type pr : putative regulator; putative HTH-type transcriptional regulator yiaG 4028935..4029231 Escherichia coli IAI39 7150224 YP_002409778.1 CDS envZ NC_011750.1 4029263 4030615 R membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein complement(4029263..4030615) Escherichia coli IAI39 7150225 YP_002409779.1 CDS ompR NC_011750.1 4030612 4031331 R part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator complement(4030612..4031331) Escherichia coli IAI39 7151231 YP_002409780.1 CDS greB NC_011750.1 4031559 4032035 D necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 4031559..4032035 Escherichia coli IAI39 7152296 YP_002409781.1 CDS yhgF NC_011750.1 4032132 4034453 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8755871; Product type f : factor; transcriptional accessory protein 4032132..4034453 Escherichia coli IAI39 7151584 YP_002409782.1 CDS feoA NC_011750.1 4034891 4035118 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012482, 8407793; Product type t : transporter; ferrous iron transport protein A 4034891..4035118 Escherichia coli IAI39 7154097 YP_002409783.1 CDS feoB NC_011750.1 4035135 4037456 D cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 4035135..4037456 Escherichia coli IAI39 7151301 YP_002409784.1 CDS yhgG NC_011750.1 4037456 4037692 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4037456..4037692 Escherichia coli IAI39 7151302 YP_002409785.1 CDS yhgA NC_011750.1 4037895 4038773 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2678009; Product type ph : phenotype; hypothetical protein 4037895..4038773 Escherichia coli IAI39 7154098 YP_002409786.1 CDS bioH NC_011750.1 4038802 4039572 R Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH complement(4038802..4039572) Escherichia coli IAI39 7154095 YP_002409787.1 CDS gntX NC_011750.1 4039610 4040293 D involved in high-affinity gluconate transport; gluconate periplasmic binding protein 4039610..4040293 Escherichia coli IAI39 7150867 YP_002409788.1 CDS gntY NC_011750.1 4040352 4040927 D cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; putative DNA uptake protein 4040352..4040927 Escherichia coli IAI39 7151574 YP_002409789.1 CDS gntT NC_011750.1 4041279 4042595 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 4574689, 4582156, 93139975, 97141270, 98019089, 2845225, 3040894, 7984428, 9045817; Product type t : transporter; gluconate transporter, high-affinity GNT I system 4041279..4042595 Escherichia coli IAI39 7151575 YP_002409790.1 CDS malQ NC_011750.1 4042640 4044724 R amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase complement(4042640..4044724) Escherichia coli IAI39 7151572 YP_002409791.1 CDS malP NC_011750.1 4044734 4047127 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89033892, 10220320, 10469642, 2845225, 3037809, 3155826, 6283313, 6339728, 6986282, 9009262; Product type e : enzyme; maltodextrin phosphorylase complement(4044734..4047127) Escherichia coli IAI39 7152002 YP_002409792.1 CDS malT NC_011750.1 4047750 4050455 D Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 4047750..4050455 Escherichia coli IAI39 7152001 YP_002409793.1 CDS rtcA NC_011750.1 4050498 4051514 R catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase complement(4050498..4051514) Escherichia coli IAI39 7152004 YP_002409794.1 CDS rtcB NC_011750.1 4051518 4052744 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9738023; hypothetical protein complement(4051518..4052744) Escherichia coli IAI39 7152758 YP_002409795.1 CDS rtcR NC_011750.1 4052933 4054531 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9738023, 3045764, 7920643, 7984428; Product type r : regulator; sigma 54-dependent transcriptional regulator of rtcBA expression 4052933..4054531 Escherichia coli IAI39 7152759 YP_002409796.1 CDS glpR NC_011750.1 4054513 4055271 R represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR complement(4054513..4055271) Escherichia coli IAI39 7152760 YP_002409797.1 CDS glpG NC_011750.1 4055288 4056118 R protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG complement(4055288..4056118) Escherichia coli IAI39 7151545 YP_002409798.1 CDS glpE NC_011750.1 4056163 4056489 R belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase complement(4056163..4056489) Escherichia coli IAI39 7151542 YP_002409799.1 CDS glpD NC_011750.1 4056679 4058184 D in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 4056679..4058184 Escherichia coli IAI39 7151540 YP_002409800.1 CDS ECIAI39_3907 NC_011750.1 4059001 4059993 R Evidence 4 : Homologs of previously reported genes of unknown function; putative ABC transporter ATP binding protein complement(4059001..4059993) Escherichia coli IAI39 7151539 YP_002409801.1 CDS ECIAI39_3908 NC_011750.1 4060019 4061536 R Evidence 4 : Homologs of previously reported genes of unknown function; putative ABC transporter ATP binding protein complement(4060019..4061536) Escherichia coli IAI39 7150226 YP_002409802.1 CDS glgP NC_011750.1 4061653 4064100 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88330897, 91104907, 91236706, 2645169, 2975249, 3047129, 3097003; Product type e : enzyme; glycogen phosphorylase complement(4061653..4064100) Escherichia coli IAI39 7150227 YP_002409803.1 CDS glgA NC_011750.1 4064119 4065552 R catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase complement(4064119..4065552) Escherichia coli IAI39 7151515 YP_002409804.1 CDS glgC NC_011750.1 4065552 4066847 R catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase complement(4065552..4066847) Escherichia coli IAI39 7151512 YP_002409805.1 CDS glgX NC_011750.1 4066865 4068838 R catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching enzyme complement(4066865..4068838) Escherichia coli IAI39 7151514 YP_002409806.1 CDS glgB NC_011750.1 4068835 4071021 R catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme complement(4068835..4071021) Escherichia coli IAI39 7151517 YP_002409807.1 CDS asd NC_011750.1 4071294 4072397 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(4071294..4072397) Escherichia coli IAI39 7151513 YP_002409808.1 CDS yhgN NC_011750.1 4072589 4073182 D YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); putative dITP- and XTP- hydrolase 4072589..4073182 Escherichia coli IAI39 7150798 YP_002409809.1 CDS ECIAI39_3916 NC_011750.1 4073228 4074523 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4073228..4074523) Escherichia coli IAI39 7154099 YP_002409810.1 CDS ECIAI39_3917 NC_011750.1 4074430 4076526 R Evidence 4 : Homologs of previously reported genes of unknown function; putative superfamily II DNA helicase complement(4074430..4076526) Escherichia coli IAI39 7150228 YP_002409811.1 CDS gntU NC_011750.1 4076666 4078006 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8655507, 9119199, 9135111, 97141270; Product type t : transporter; low affinity gluconate transporter complement(4076666..4078006) Escherichia coli IAI39 7150229 YP_002409812.1 CDS gntK NC_011750.1 4078010 4078537 R thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase 1 complement(4078010..4078537) Escherichia coli IAI39 7151573 YP_002409813.1 CDS gntR NC_011750.1 4078676 4079671 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 9135111, 93139975, 9537375, 8655507; Product type r : regulator; DNA-binding transcriptional repressor complement(4078676..4079671) Escherichia coli IAI39 7151569 YP_002409814.1 CDS yhhW NC_011750.1 4079895 4080590 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4079895..4080590) Escherichia coli IAI39 7151571 YP_002409815.1 CDS yhhX NC_011750.1 4080713 4081750 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10493123; Product type pe : putative enzyme; putative dehydrogenase complement(4080713..4081750) Escherichia coli IAI39 7154110 YP_002409816.1 CDS yhhY NC_011750.1 4082084 4082572 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase 4082084..4082572 Escherichia coli IAI39 7152792 YP_002409817.1 CDS yhhZ NC_011750.1 4082808 4083986 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4082808..4083986 Escherichia coli IAI39 7154112 YP_002409818.1 CDS yrhA NC_011750.1 4083983 4084477 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4083983..4084477 Escherichia coli IAI39 7154113 YP_002409819.1 CDS yrhB NC_011750.1 4084927 4085211 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4084927..4085211 Escherichia coli IAI39 7154565 YP_002409820.1 CDS ggt NC_011750.1 4085249 4087021 R periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase complement(4085249..4087021) Escherichia coli IAI39 7154566 YP_002409821.1 CDS yhhA NC_011750.1 4087114 4087554 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4087114..4087554 Escherichia coli IAI39 7151502 YP_002409822.1 CDS ugpQ NC_011750.1 4087541 4088284 R hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; cytoplasmic glycerophosphodiester phosphodiesterase complement(4087541..4088284) Escherichia coli IAI39 7154100 YP_002409823.1 CDS ugpC NC_011750.1 4088281 4089351 R part of the UgpABCE glycerol-3-phosphate uptake system; glycerol-3-phosphate transporter ATP-binding subunit complement(4088281..4089351) Escherichia coli IAI39 7153085 YP_002409824.1 CDS ugpE NC_011750.1 4089353 4090198 R with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein complement(4089353..4090198) Escherichia coli IAI39 7153083 YP_002409825.1 CDS ugpA NC_011750.1 4090195 4091082 R with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease complement(4090195..4091082) Escherichia coli IAI39 7153084 YP_002409826.1 CDS ugpB NC_011750.1 4091180 4092496 R with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein complement(4091180..4092496) Escherichia coli IAI39 7153081 YP_002409827.1 CDS ECIAI39_3934 NC_011750.1 4092856 4093602 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4092856..4093602) Escherichia coli IAI39 7153082 YP_002409828.1 CDS livF NC_011750.1 4093721 4094434 R with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit complement(4093721..4094434) Escherichia coli IAI39 7150230 YP_002409829.1 CDS livG NC_011750.1 4094436 4095203 R Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit complement(4094436..4095203) Escherichia coli IAI39 7151940 YP_002409830.1 CDS livM NC_011750.1 4095200 4096477 R Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease subunit complement(4095200..4096477) Escherichia coli IAI39 7151941 YP_002409831.1 CDS livH NC_011750.1 4096474 4097400 R LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid transporter permease subunit LivH complement(4096474..4097400) Escherichia coli IAI39 7151945 YP_002409832.1 CDS livK NC_011750.1 4097448 4098557 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702302, 90307651, 2195019, 2649683, 3891753, 4077929, 9298646, 9298646; Product type t : transporter; leucine ABC transporter subunit periplasmic-binding protein complement(4097448..4098557) Escherichia coli IAI39 7151942 YP_002409833.1 CDS yhhK NC_011750.1 4098981 4099364 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4098981..4099364 Escherichia coli IAI39 7151944 YP_002409834.1 CDS livJ NC_011750.1 4099552 4100655 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702302, 90307651, 2195019, 2649682, 328304, 3891753, 4077929, 9298646, 10972807; Product type t : transporter; leucine/isoleucine/valine ABC transporter subunit periplasmic-binding protein complement(4099552..4100655) Escherichia coli IAI39 7154103 YP_002409835.1 CDS rpoH NC_011750.1 4100927 4101781 R binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 complement(4100927..4101781) Escherichia coli IAI39 7151943 YP_002409836.1 CDS ftsX NC_011750.1 4102026 4103084 R putative ABC transporter, membrane protein; cell division protein FtsX complement(4102026..4103084) Escherichia coli IAI39 7152708 YP_002409837.1 CDS ftsE NC_011750.1 4103077 4103745 R putative ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE complement(4103077..4103745) Escherichia coli IAI39 7151443 YP_002409838.1 CDS ftsY NC_011750.1 4103748 4105235 R signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY complement(4103748..4105235) Escherichia coli IAI39 7151435 YP_002409839.1 CDS rsmD NC_011750.1 4105385 4105981 D catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 4105385..4105981 Escherichia coli IAI39 7151444 YP_002409840.1 CDS yhhL NC_011750.1 4105971 4106240 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4105971..4106240 Escherichia coli IAI39 7154101 YP_002409841.1 CDS yhhM NC_011750.1 4106243 4106602 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4106243..4106602) Escherichia coli IAI39 7154104 YP_002409842.1 CDS yhhN NC_011750.1 4106743 4107369 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4106743..4107369 Escherichia coli IAI39 7154105 YP_002409843.1 CDS zntA NC_011750.1 4107443 4109641 D P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 4107443..4109641 Escherichia coli IAI39 7154106 YP_002409844.1 CDS tusA NC_011750.1 4109743 4109988 R TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA complement(4109743..4109988) Escherichia coli IAI39 7154590 YP_002409845.1 CDS yhhQ NC_011750.1 4110209 4110874 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4110209..4110874 Escherichia coli IAI39 7153057 YP_002409846.1 CDS dcrB NC_011750.1 4110947 4111504 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12558182, 8752353; Product type t : transporter; hypothetical protein 4110947..4111504 Escherichia coli IAI39 7154107 YP_002409847.1 CDS yhhS NC_011750.1 4111508 4112725 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; major facilitator superfamily transporter complement(4111508..4112725) Escherichia coli IAI39 7151093 YP_002409848.1 CDS yhhT NC_011750.1 4112857 4113906 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4112857..4113906 Escherichia coli IAI39 7154108 YP_002409849.1 CDS acpT NC_011750.1 4113961 4114548 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20092861, 10625633, 8939709; Product type e : enzyme; holo-(acyl carrier protein) synthase 2 4113961..4114548 Escherichia coli IAI39 7154109 YP_002409850.1 CDS nikA NC_011750.1 4114659 4116233 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12960164, 7934931, 92077434, 7867647; Product type t : transporter; nickel ABC transporter subunit periplasmic-binding protein 4114659..4116233 Escherichia coli IAI39 7150671 YP_002409851.1 CDS nikB NC_011750.1 4116233 4117177 D with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 4116233..4117177 Escherichia coli IAI39 7152224 YP_002409852.1 CDS nikC NC_011750.1 4117174 4118007 D with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 4117174..4118007 Escherichia coli IAI39 7152225 YP_002409853.1 CDS nikD NC_011750.1 4118007 4118771 D with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 4118007..4118771 Escherichia coli IAI39 7152226 YP_002409854.1 CDS nikE NC_011750.1 4118768 4119574 D with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 4118768..4119574 Escherichia coli IAI39 7152227 YP_002409855.1 CDS nikR NC_011750.1 4119579 4119980 D Inhibits transcription at high concentrations of nickel; nickel responsive regulator 4119579..4119980 Escherichia coli IAI39 7152228 YP_002409856.1 CDS ECIAI39_3963 NC_011750.1 4120170 4120925 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4120170..4120925 Escherichia coli IAI39 7152229 YP_002409857.1 CDS ECIAI39_3964 NC_011750.1 4120950 4121423 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system enzyme subunit IIA 4120950..4121423 Escherichia coli IAI39 7150231 YP_002409858.1 CDS ECIAI39_3965 NC_011750.1 4121420 4121701 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphotransferase system enzyme IIB 4121420..4121701 Escherichia coli IAI39 7150232 YP_002409859.1 CDS ECIAI39_3966 NC_011750.1 4121745 4123133 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative phosphotransferase system permease component IIC 4121745..4123133 Escherichia coli IAI39 7150233 YP_002409860.1 CDS ECIAI39_3967 NC_011750.1 4123126 4124634 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative carbohydrate kinase 4123126..4124634 Escherichia coli IAI39 7150234 YP_002409861.1 CDS ECIAI39_3968 NC_011750.1 4124624 4124893 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative phosphocarrier HPr protein of a carbohydrate phosphotransferase system 4124624..4124893 Escherichia coli IAI39 7150235 YP_002409862.1 CDS gatY NC_011750.1 4124925 4125785 D class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; putative fructose-1,6-bisphosphate aldolase 4124925..4125785 Escherichia coli IAI39 7150236 YP_002409863.1 CDS ECIAI39_3970 NC_011750.1 4125835 4126194 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4125835..4126194) Escherichia coli IAI39 7150237 YP_002409864.1 CDS yhhJ NC_011750.1 4126539 4127663 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative ABC transporter membrane protein complement(4126539..4127663) Escherichia coli IAI39 7150238 YP_002409865.1 CDS rbbA NC_011750.1 4127663 4130398 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20074572; Product type e : enzyme; ribosome-associated ATPase/membrane protein complement(4127663..4130398) Escherichia coli IAI39 7154102 YP_002409866.1 CDS yhiI NC_011750.1 4130395 4131462 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative HlyD family secretion protein complement(4130395..4131462) Escherichia coli IAI39 7152568 YP_002409867.1 CDS yhiJ NC_011750.1 4131828 4133450 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4131828..4133450) Escherichia coli IAI39 7154116 YP_002409868.1 CDS insG NC_011750.1 4133811 4135157 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative IS4 transposase; KpLE2 phage-like element 4133811..4135157 Escherichia coli IAI39 7154117 YP_002409869.1 CDS ECIAI39_3976 NC_011750.1 4135146 4136825 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4135146..4136825) Escherichia coli IAI39 7151817 YP_002409870.1 CDS ECIAI39_3977 NC_011750.1 4136716 4136925 R Evidence 6 : Doubtful CDS; hypothetical protein complement(4136716..4136925) Escherichia coli IAI39 7150239 YP_002409871.1 CDS ECIAI39_3979 NC_011750.1 4137054 4137152 R hypothetical protein complement(4137054..4137152) Escherichia coli IAI39 7150240 YP_002409872.1 CDS yhiM NC_011750.1 4137124 4138176 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4137124..4138176 Escherichia coli IAI39 7150241 YP_002409873.1 CDS ECIAI39_3980 NC_011750.1 4137924 4138256 R hypothetical protein complement(4137924..4138256) Escherichia coli IAI39 7154118 YP_002409874.1 CDS yhiN NC_011750.1 4138491 4139693 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(4138491..4139693) Escherichia coli IAI39 7150242 YP_002409875.1 CDS pitA NC_011750.1 4139925 4141424 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87014120; Product type t : transporter; phosphate transporter, low-affinity 4139925..4141424 Escherichia coli IAI39 7154119 YP_002409876.1 CDS yhiO NC_011750.1 4141495 4141830 R ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB complement(4141495..4141830) Escherichia coli IAI39 7152423 YP_002409877.1 CDS uspA NC_011750.1 4142221 4142655 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 93086426, 93308072, 94203056, 10499297, 10652104, 10931298, 11157932, 1453957, 8506346, 8932299, 9298646, 9405142; Product type f : factor; universal stress global response regulator 4142221..4142655 Escherichia coli IAI39 7154120 YP_002409878.1 CDS yhiP NC_011750.1 4142971 4144440 D member of the POT family of peptide transporters; probable proton-dependent peptide transporter function; inner membrane transporter YhiP 4142971..4144440 Escherichia coli IAI39 7153108 YP_002409879.1 CDS yhiQ NC_011750.1 4144489 4145241 R predicted SAM-dependent methyltransferase; putative methyltransferase complement(4144489..4145241) Escherichia coli IAI39 7154121 YP_002409880.1 CDS prlC NC_011750.1 4145249 4147291 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92394891, 1325967, 8366062; Product type e : enzyme; oligopeptidase A complement(4145249..4147291) Escherichia coli IAI39 7154122 YP_002409881.1 CDS yhiR NC_011750.1 4147494 4148336 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11591672; Product type pe : putative enzyme; putative DNA (exogenous) processing protein 4147494..4148336 Escherichia coli IAI39 7152479 YP_002409882.1 CDS gor NC_011750.1 4148408 4149760 D catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 4148408..4149760 Escherichia coli IAI39 7154123 YP_002409883.1 CDS ECIAI39_3991 NC_011750.1 4149814 4149963 R Evidence 6 : Doubtful CDS; hypothetical protein complement(4149814..4149963) Escherichia coli IAI39 7151576 YP_002409884.1 CDS ECIAI39_3992 NC_011750.1 4149919 4150098 D Evidence 6 : Doubtful CDS; hypothetical protein 4149919..4150098 Escherichia coli IAI39 7150243 YP_002409885.1 CDS arsR NC_011750.1 4150636 4150989 D regulates the expression of of the arsRBC involved in resistance to arsenic; DNA-binding transcriptional repressor ArsR 4150636..4150989 Escherichia coli IAI39 7150244 YP_002409886.1 CDS arsB NC_011750.1 4151044 4152333 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15004242, 95355341, 1535622, 7721697; Product type t : transporter; arsenite/antimonite transporter 4151044..4152333 Escherichia coli IAI39 7150789 YP_002409887.1 CDS arsC NC_011750.1 4152346 4152771 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95355341, 7721697; Product type e : enzyme; arsenate reductase 4152346..4152771 Escherichia coli IAI39 7150787 YP_002409888.1 CDS ECIAI39_3996 NC_011750.1 4152792 4153112 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4152792..4153112) Escherichia coli IAI39 7150788 YP_002409889.1 CDS ECIAI39_3997 NC_011750.1 4153208 4154221 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; hypothetical protein 4153208..4154221 Escherichia coli IAI39 7150245 YP_002409890.1 CDS ECIAI39_3998 NC_011750.1 4154802 4156025 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4154802..4156025 Escherichia coli IAI39 7150246 YP_002409891.1 CDS slp NC_011750.1 4156271 4156837 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293775, 8022277; Product type lp : lipoprotein; outer membrane lipoprotein 4156271..4156837 Escherichia coli IAI39 7150247 YP_002409892.1 CDS yhiF NC_011750.1 4156990 4157520 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8022277; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4156990..4157520 Escherichia coli IAI39 7152858 YP_002409893.1 CDS chuS NC_011750.1 4157581 4158609 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16275907; Product type e : enzyme; Heme oxygenase complement(4157581..4158609) Escherichia coli IAI39 7154115 YP_002409894.1 CDS chuA NC_011750.1 4158658 4160640 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11179376, 7768795, 9393841, 9680204, 9157252; Product type t : transporter; outer membrane hemin receptor complement(4158658..4160640) Escherichia coli IAI39 7150945 YP_002409895.1 CDS ECIAI39_4003 NC_011750.1 4160477 4160737 D Evidence 6 : Doubtful CDS; hypothetical protein 4160477..4160737 Escherichia coli IAI39 7150944 YP_002409896.1 CDS chuT NC_011750.1 4161246 4162238 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7768795, 9393841, 9680204; Product type pt : putative transporter; putative periplasmic binding protein 4161246..4162238 Escherichia coli IAI39 7150248 YP_002409897.1 CDS ECIAI39_4005 NC_011750.1 4162258 4163595 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4162258..4163595 Escherichia coli IAI39 7150946 YP_002409898.1 CDS ECIAI39_4006 NC_011750.1 4163608 4164102 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4163608..4164102 Escherichia coli IAI39 7150249 YP_002409899.1 CDS ECIAI39_4007 NC_011750.1 4164102 4164725 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4164102..4164725 Escherichia coli IAI39 7150250 YP_002409900.1 CDS chuU NC_011750.1 4164774 4165766 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative hemin transport system permease 4164774..4165766 Escherichia coli IAI39 7150251 YP_002409901.1 CDS hmuV NC_011750.1 4165733 4166533 D with HmuTU is involved in the transport of hemin; hemin importer ATP-binding subunit 4165733..4166533 Escherichia coli IAI39 7150947 YP_002409902.1 CDS yhiD NC_011750.1 4166585 4167232 R inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli; putative Mg(2+) transport ATPase complement(4166585..4167232) Escherichia coli IAI39 7150948 YP_002409903.1 CDS hdeB NC_011750.1 4167296 4167622 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94064579, 8885264, 12071744, 8244952, 8455549, 9298646, 9868784; Product type pf : putative factor; acid-resistance protein complement(4167296..4167622) Escherichia coli IAI39 7154114 YP_002409904.1 CDS hdeA NC_011750.1 4167738 4168070 R inactive form; acid-resistance protein complement(4167738..4168070) Escherichia coli IAI39 7151619 YP_002409905.1 CDS hdeD NC_011750.1 4168325 4168897 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94064579, 8244952, 8455549; Product type pm : putative membrane component; acid-resistance membrane protein 4168325..4168897 Escherichia coli IAI39 7151618 YP_002409906.1 CDS gadE NC_011750.1 4169695 4170222 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12399493, 12940989, 14702398; Product type r : regulator; DNA-binding transcriptional activator 4169695..4170222 Escherichia coli IAI39 7151620 YP_002409907.1 CDS mdtE NC_011750.1 4170560 4171717 D with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds; multidrug efflux system protein MdtE 4170560..4171717 Escherichia coli IAI39 7151466 YP_002409908.1 CDS mdtF NC_011750.1 4171742 4174855 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803; Product type t : transporter; multidrug transporter, RpoS-dependent 4171742..4174855 Escherichia coli IAI39 7152032 YP_002409909.1 CDS gadW NC_011750.1 4175218 4175946 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12446650; Product type r : regulator; DNA-binding transcriptional activator complement(4175218..4175946) Escherichia coli IAI39 7152033 YP_002409910.1 CDS gadX NC_011750.1 4176315 4177139 R regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX complement(4176315..4177139) Escherichia coli IAI39 7151469 YP_002409911.1 CDS gadA NC_011750.1 4177508 4178908 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92155241, 92394884, 99406302, 1522060, 1740158, 7764225, 9298646; Product type e : enzyme; glutamate decarboxylase A, PLP-dependent complement(4177508..4178908) Escherichia coli IAI39 7151468 YP_002409912.1 CDS yhjA NC_011750.1 4179119 4180516 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8163487, 14563563; Product type e : enzyme; cytochrome C peroxidase (cpp-like) complement(4179119..4180516) Escherichia coli IAI39 7151463 YP_002409913.1 CDS treF NC_011750.1 4180921 4182570 D cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 4180921..4182570 Escherichia coli IAI39 7154124 YP_002409914.1 CDS yhjB NC_011750.1 4182621 4183223 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding response regulator in two-component regulatory system complement(4182621..4183223) Escherichia coli IAI39 7153020 YP_002409915.1 CDS yhjC NC_011750.1 4183670 4184641 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4183670..4184641 Escherichia coli IAI39 7154125 YP_002409916.1 CDS yhjD NC_011750.1 4184690 4185703 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4184690..4185703 Escherichia coli IAI39 7154126 YP_002409917.1 CDS yhjE NC_011750.1 4186095 4187417 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4186095..4187417 Escherichia coli IAI39 7154127 YP_002409918.1 CDS yhjG NC_011750.1 4187596 4189671 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane biogenesis protein complement(4187596..4189671) Escherichia coli IAI39 7154128 YP_002409919.1 CDS yhjH NC_011750.1 4189726 4190493 R in Escherichia coli this protein is involved in flagellar function; EAL domain-containing protein complement(4189726..4190493) Escherichia coli IAI39 7154129 YP_002409920.1 CDS kdgK NC_011750.1 4190725 4191654 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4359651, 13813474; Product type e : enzyme; ketodeoxygluconokinase 4190725..4191654 Escherichia coli IAI39 7154130 YP_002409921.1 CDS yhjJ NC_011750.1 4191751 4193247 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pe : putative enzyme; putative zinc-dependent peptidase complement(4191751..4193247) Escherichia coli IAI39 7151877 YP_002409922.1 CDS dctA NC_011750.1 4193467 4194753 R involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA complement(4193467..4194753) Escherichia coli IAI39 7154131 YP_002409923.1 CDS yhjK NC_011750.1 4194936 4196885 R HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a putative phosphodiesterase protein from E. coli; putative phosphodiesterase complement(4194936..4196885) Escherichia coli IAI39 7151094 YP_002409924.1 CDS bcsC NC_011750.1 4197006 4200479 R cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA; cellulose synthase subunit BcsC complement(4197006..4200479) Escherichia coli IAI39 7154132 YP_002409925.1 CDS bcsZ NC_011750.1 4200461 4201567 R catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase complement(4200461..4201567) Escherichia coli IAI39 7150845 YP_002409926.1 CDS bcsB NC_011750.1 4201574 4203913 R binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein complement(4201574..4203913) Escherichia coli IAI39 7150850 YP_002409927.1 CDS bcsA NC_011750.1 4203924 4206530 R polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis; cellulose synthase catalytic subunit complement(4203924..4206530) Escherichia coli IAI39 7150844 YP_002409928.1 CDS ECIAI39_4038 NC_011750.1 4206520 4207272 R cell division protein complement(4206520..4207272) Escherichia coli IAI39 7150843 YP_002409929.1 CDS yhjR NC_011750.1 4207284 4207472 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4207284..4207472) Escherichia coli IAI39 7150252 YP_002409930.1 CDS bcsE NC_011750.1 4207744 4209315 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929533, 11260463; Product type pe : putative enzyme; putative cellulose biosynthesis protease 4207744..4209315 Escherichia coli IAI39 7154133 YP_002409931.1 CDS bcsF NC_011750.1 4209312 4209503 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4209312..4209503 Escherichia coli IAI39 7150846 YP_002409932.1 CDS insG NC_011750.1 4209927 4211273 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase, IS4 4209927..4211273 Escherichia coli IAI39 7150848 YP_002409933.1 CDS ECIAI39_4047 NC_011750.1 4214428 4214589 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4214428..4214589) Escherichia coli IAI39 7152586 YP_002409934.1 CDS yhjV NC_011750.1 4214739 4216010 D Evidence 2b : Function of strongly homologous gene; PubMedId : 15901718; Product type t : transporter; transporter 4214739..4216010 Escherichia coli IAI39 7150253 YP_002409935.1 CDS dppF NC_011750.1 4216040 4217044 R Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit complement(4216040..4217044) Escherichia coli IAI39 7154134 YP_002409936.1 CDS dppD NC_011750.1 4217041 4218024 R DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit complement(4217041..4218024) Escherichia coli IAI39 7151170 YP_002409937.1 CDS dppC NC_011750.1 4218035 4218937 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7536291; Product type t : transporter; dipeptide transporter complement(4218035..4218937) Escherichia coli IAI39 7151169 YP_002409938.1 CDS dppB NC_011750.1 4218947 4219966 R transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB complement(4218947..4219966) Escherichia coli IAI39 7151168 YP_002409939.1 CDS dppA NC_011750.1 4220117 4221724 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100289, 92065799, 1702779, 1956284, 7536291, 8527431, 8563629, 9298646, 9600841, 9740056, 10972807; Product type t : transporter; dipeptide ABC transporter periplasmic-binding protein complement(4220117..4221724) Escherichia coli IAI39 7151167 YP_002409940.1 CDS eptB NC_011750.1 4222636 4224327 R catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase complement(4222636..4224327) Escherichia coli IAI39 7150589 YP_002409941.1 CDS yhjX NC_011750.1 4224651 4225859 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(4224651..4225859) Escherichia coli IAI39 7151237 YP_002409942.1 CDS yhjY NC_011750.1 4226088 4226786 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4226088..4226786) Escherichia coli IAI39 7154135 YP_002409943.1 CDS tag NC_011750.1 4226944 4227507 D constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyl-adenine DNA glycosylase I 4226944..4227507 Escherichia coli IAI39 7154136 YP_002409944.1 CDS yiaC NC_011750.1 4227504 4227944 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11237876; Product type pe : putative enzyme; hypothetical protein 4227504..4227944 Escherichia coli IAI39 7152937 YP_002409945.1 CDS bisC NC_011750.1 4227913 4230192 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82119950, 90202748, 2180922, 374979; Product type e : enzyme; biotin sulfoxide reductase complement(4227913..4230192) Escherichia coli IAI39 7154139 YP_002409946.1 CDS yiaD NC_011750.1 4230399 4231058 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative outer membrane lipoprotein 4230399..4231058 Escherichia coli IAI39 7150870 YP_002409947.1 CDS tiaE NC_011750.1 4231162 4232136 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15801772, 11237876, 99030322, 99357626, 9298646, 9811658; Product type e : enzyme; 2-oxo-carboxylic acid reductase 4231162..4232136 Escherichia coli IAI39 7154140 YP_002409948.1 CDS yiaF NC_011750.1 4232186 4232896 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4232186..4232896) Escherichia coli IAI39 7152985 YP_002409949.1 CDS yiaG NC_011750.1 4233330 4233620 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4233330..4233620 Escherichia coli IAI39 7154141 YP_002409950.1 CDS cspA NC_011750.1 4233901 4234113 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20345064, 90115858, 94293754, 94293756, 99177178, 10696873, 1597410, 1961761, 2404279, 7515185, 8197194, 9405743, 9439003, 9692981; Product type f : factor; major cold shock protein 4233901..4234113 Escherichia coli IAI39 7154142 YP_002409951.1 CDS insK NC_011750.1 4234556 4235407 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99350411; Product type h : extrachromosomal origin; IS150 conserved protein InsB complement(4234556..4235407) Escherichia coli IAI39 7151012 YP_002409952.1 CDS insJ NC_011750.1 4235404 4235925 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2541046, 2841644; Product type h : extrachromosomal origin; IS150 protein InsA complement(4235404..4235925) Escherichia coli IAI39 7151822 YP_002409953.1 CDS glyS NC_011750.1 4236224 4238293 R glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(4236224..4238293) Escherichia coli IAI39 7151821 YP_002409954.1 CDS glyQ NC_011750.1 4238303 4239214 R glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(4238303..4239214) Escherichia coli IAI39 7151561 YP_002409955.1 CDS ysaB NC_011750.1 4239309 4239608 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4239309..4239608) Escherichia coli IAI39 7151560 YP_002409956.1 CDS ECIAI39_4071 NC_011750.1 4240165 4241055 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 complement(4240165..4241055) Escherichia coli IAI39 7154143 YP_002409957.1 CDS ECIAI39_4072 NC_011750.1 4241052 4241378 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 complement(4241052..4241378) Escherichia coli IAI39 7150254 YP_002409958.1 CDS yiaA NC_011750.1 4242133 4242570 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4242133..4242570) Escherichia coli IAI39 7154144 YP_002409959.1 CDS xylB NC_011750.1 4243028 4244482 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6330500, 92366447, 95050816, 6320721; Product type e : enzyme; xylulokinase complement(4243028..4244482) Escherichia coli IAI39 7154138 YP_002409960.1 CDS xylA NC_011750.1 4244554 4245876 R catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase complement(4244554..4245876) Escherichia coli IAI39 7153186 YP_002409961.1 CDS xylF NC_011750.1 4246242 4247234 D periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 4246242..4247234 Escherichia coli IAI39 7153185 YP_002409962.1 CDS xylG NC_011750.1 4247312 4248853 D with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit 4247312..4248853 Escherichia coli IAI39 7153187 YP_002409963.1 CDS xylH NC_011750.1 4248831 4250012 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94316500; Product type t : transporter; D-xylose ABC transporter membrane protein 4248831..4250012 Escherichia coli IAI39 7153188 YP_002409964.1 CDS xylR NC_011750.1 4250090 4251268 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6330500, 94316500; Product type r : regulator; DNA-binding transcriptional activator, xylose-binding 4250090..4251268 Escherichia coli IAI39 7153189 YP_002409965.1 CDS bax NC_011750.1 4251376 4252200 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1544897; hypothetical protein complement(4251376..4252200) Escherichia coli IAI39 7153190 YP_002409966.1 CDS malS NC_011750.1 4252520 4254550 D periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase 4252520..4254550 Escherichia coli IAI39 7150840 YP_002409967.1 CDS avtA NC_011750.1 4254728 4255981 D transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 4254728..4255981 Escherichia coli IAI39 7152003 YP_002409968.1 CDS yiaI NC_011750.1 4256020 4256493 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative hydrogenase, 4Fe-4S ferredoxin-type component complement(4256020..4256493) Escherichia coli IAI39 7150830 YP_002409969.1 CDS yiaJ NC_011750.1 4256595 4257443 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 20372646, 9826648; Product type r : regulator; DNA-binding transcriptional repressor complement(4256595..4257443) Escherichia coli IAI39 7154145 YP_002409970.1 CDS yiaK NC_011750.1 4257645 4258643 D NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; 2,3-diketo-L-gulonate reductase 4257645..4258643 Escherichia coli IAI39 7154146 YP_002409971.1 CDS yiaL NC_011750.1 4258655 4259122 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21617392; hypothetical protein 4258655..4259122 Escherichia coli IAI39 7154147 YP_002409972.1 CDS yiaM NC_011750.1 4259240 4259713 D membrane-spanning protein involved in uptake of 2,3-diketo-L-gulonate; part of the tri-partite ATP-independent periplasmic transport system (TRAP) YiaMNO; 2,3-diketo-L-gulonate TRAP transporter small permease YiaM 4259240..4259713 Escherichia coli IAI39 7154148 YP_002409973.1 CDS yiaN NC_011750.1 4259716 4260993 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14668138, 21617392; Product type t : transporter; transporter 4259716..4260993 Escherichia coli IAI39 7154149 YP_002409974.1 CDS yiaO NC_011750.1 4261006 4261992 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14668138, 21617392; Product type t : transporter; transporter 4261006..4261992 Escherichia coli IAI39 7154150 YP_002409975.1 CDS lyxK NC_011750.1 4261996 4263492 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21617392, 95050816, 7961955; Product type e : enzyme; L-xylulose kinase 4261996..4263492 Escherichia coli IAI39 7154151 YP_002409976.1 CDS sgbH NC_011750.1 4263489 4264151 D catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate; 3-keto-L-gulonate-6-phosphate decarboxylase 4263489..4264151 Escherichia coli IAI39 7151988 YP_002409977.1 CDS sgbU NC_011750.1 4264144 4265004 D L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; putative L-xylulose 5-phosphate 3-epimerase 4264144..4265004 Escherichia coli IAI39 7152845 YP_002409978.1 CDS sgbE NC_011750.1 4264998 4265693 D catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4264998..4265693 Escherichia coli IAI39 7152846 YP_002409979.1 CDS ECIAI39_4096 NC_011750.1 4265725 4266540 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator protein complement(4265725..4266540) Escherichia coli IAI39 7152844 YP_002409980.1 CDS ECIAI39_4097 NC_011750.1 4266766 4268166 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease of the major facilitator superfamily 4266766..4268166 Escherichia coli IAI39 7150256 YP_002409981.1 CDS yiaT NC_011750.1 4270277 4271017 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4270277..4271017) Escherichia coli IAI39 7150259 YP_002409982.1 CDS yiaU NC_011750.1 4271141 4272115 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4271141..4272115 Escherichia coli IAI39 7154152 YP_002409983.1 CDS yiaV NC_011750.1 4272112 4273248 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15668009; Product type t : transporter; membrane fusion protein (MFP) component of efflux pump, signal anchor complement(4272112..4273248) Escherichia coli IAI39 7154153 YP_002409984.1 CDS yiaW NC_011750.1 4273254 4273577 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4273254..4273577) Escherichia coli IAI39 7154154 YP_002409985.1 CDS ECIAI39_4104 NC_011750.1 4273691 4273903 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4273691..4273903 Escherichia coli IAI39 7154155 YP_002409986.1 CDS aldB NC_011750.1 4274122 4275660 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95286498, 7768815; Product type e : enzyme; aldehyde dehydrogenase B complement(4274122..4275660) Escherichia coli IAI39 7150260 YP_002409987.1 CDS ECIAI39_4106 NC_011750.1 4275768 4277063 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4275768..4277063) Escherichia coli IAI39 7150712 YP_002409988.1 CDS yiaY NC_011750.1 4277238 4278344 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2935393; Product type e : enzyme; putative alcohol dehydrogenase complement(4277238..4278344) Escherichia coli IAI39 7150261 YP_002409989.1 CDS selB NC_011750.1 4278535 4280379 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264431, 91317715, 9315303, 94148228, 2140572, 2531290; Product type f : factor; selenocysteinyl-tRNA-specific translation factor complement(4278535..4280379) Escherichia coli IAI39 7154156 YP_002409990.1 CDS selA NC_011750.1 4280376 4281767 R catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase complement(4280376..4281767) Escherichia coli IAI39 7152827 YP_002409991.1 CDS yibH NC_011750.1 4282544 4283680 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4282544..4283680) Escherichia coli IAI39 7154159 YP_002409992.1 CDS yibI NC_011750.1 4283683 4284045 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4283683..4284045) Escherichia coli IAI39 7154160 YP_002409993.1 CDS mtlA NC_011750.1 4284582 4286495 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92052139, 92283796, 94131964, 1946374, 3135464, 3142516, 6309813, 9551558; Product type t : transporter; PTS system mannitol-specific transporter subunit IIABC 4284582..4286495 Escherichia coli IAI39 7154161 YP_002409994.1 CDS mtlD NC_011750.1 4286590 4287738 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90254197, 1964486, 3135464, 6384188, 8300537, 13295236; Product type e : enzyme; mannitol-1-phosphate 5-dehydrogenase 4286590..4287738 Escherichia coli IAI39 7152138 YP_002409995.1 CDS mtlR NC_011750.1 4287738 4288325 D Acts as a repressor of the mtlAD operon; mannitol repressor protein 4287738..4288325 Escherichia coli IAI39 7152139 YP_002409996.1 CDS yibT NC_011750.1 4288336 4288545 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4288336..4288545) Escherichia coli IAI39 7152140 YP_002409997.1 CDS ECIAI39_4118 NC_011750.1 4288745 4289158 R hypothetical protein complement(4288745..4289158) Escherichia coli IAI39 7154166 YP_002409998.1 CDS yibL NC_011750.1 4288829 4289191 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4288829..4289191 Escherichia coli IAI39 7150262 YP_002409999.1 CDS ECIAI39_4120 NC_011750.1 4289447 4289683 R Evidence 6 : Doubtful CDS; hypothetical protein complement(4289447..4289683) Escherichia coli IAI39 7154163 YP_002410000.1 CDS ECIAI39_4121 NC_011750.1 4289749 4290432 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4289749..4290432 Escherichia coli IAI39 7150263 YP_002410001.1 CDS lldP NC_011750.1 4295643 4297298 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012541, 11283302, 11785976, 8407843; Product type t : transporter; L-lactate permease 4295643..4297298 Escherichia coli IAI39 7150266 YP_002410002.1 CDS lldR NC_011750.1 4297298 4298074 D represses the lctPRD operon; DNA-binding transcriptional repressor LldR 4297298..4298074 Escherichia coli IAI39 7151947 YP_002410003.1 CDS lldD NC_011750.1 4298071 4299261 D flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 4298071..4299261 Escherichia coli IAI39 7151948 YP_002410004.1 CDS yibK NC_011750.1 4299334 4299807 D member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; putative tRNA/rRNA methyltransferase YibK 4299334..4299807 Escherichia coli IAI39 7151946 YP_002410005.1 CDS cysE NC_011750.1 4299860 4300681 R catalyzes the O-acetylation of serine; serine acetyltransferase complement(4299860..4300681) Escherichia coli IAI39 7154162 YP_002410006.1 CDS gpsA NC_011750.1 4300761 4301780 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(4300761..4301780) Escherichia coli IAI39 7151059 YP_002410007.1 CDS secB NC_011750.1 4301780 4302247 R molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB complement(4301780..4302247) Escherichia coli IAI39 7151581 YP_002410008.1 CDS grxC NC_011750.1 4302310 4302561 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94316500, 95024051, 99175138, 11031118, 7937896, 8636094, 9973569; Product type c : carrier; glutaredoxin 3 complement(4302310..4302561) Escherichia coli IAI39 7152819 YP_002410009.1 CDS yibN NC_011750.1 4302703 4303134 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative rhodanese-related sulfurtransferase complement(4302703..4303134) Escherichia coli IAI39 7151590 YP_002410010.1 CDS gpmI NC_011750.1 4303379 4304923 D catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 4303379..4304923 Escherichia coli IAI39 7154164 YP_002410011.1 CDS envC NC_011750.1 4304957 4306216 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12113939, 21972773; Product type cp : cell process; hypothetical protein 4304957..4306216 Escherichia coli IAI39 7151579 YP_002410012.1 CDS yibQ NC_011750.1 4306220 4307179 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative polysaccharide deacetylase 4306220..4307179 Escherichia coli IAI39 7151228 YP_002410013.1 CDS yibD NC_011750.1 4307166 4308200 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15659689, 2647748; Product type pe : putative enzyme; putative glycosyl transferase complement(4307166..4308200) Escherichia coli IAI39 7154165 YP_002410014.1 CDS tdh NC_011750.1 4308439 4309464 R converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase complement(4308439..4309464) Escherichia coli IAI39 7154157 YP_002410015.1 CDS kbl NC_011750.1 4309474 4310670 R catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase complement(4309474..4310670) Escherichia coli IAI39 7152961 YP_002410016.1 CDS rfaD NC_011750.1 4310884 4311816 D catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-mannoheptose-6-epimerase 4310884..4311816 Escherichia coli IAI39 7151875 YP_002410017.1 CDS waaF NC_011750.1 4311826 4312872 D catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose:LPS heptosyltransferase II 4311826..4312872 Escherichia coli IAI39 7153135 YP_002410018.1 CDS waaC NC_011750.1 4312876 4313847 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20507564, 92250420, 93239678, 9446588, 1624462, 8478319; Product type e : enzyme; ADP-heptose:LPS heptosyl transferase I 4312876..4313847 Escherichia coli IAI39 7153136 YP_002410019.1 CDS waaL NC_011750.1 4313917 4315170 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92250420, 92325067, 93054344, 1624462; Product type e : enzyme; lipid A-core surface O-antigen ligase complement(4313917..4315170) Escherichia coli IAI39 7153134 YP_002410020.1 CDS waaV NC_011750.1 4315216 4316199 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative beta1,3-glucosyltransferase complement(4315216..4316199) Escherichia coli IAI39 7153138 YP_002410021.1 CDS waaW NC_011750.1 4316278 4317306 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9791168, 9756860, 9792656; Product type e : enzyme; UDP-galactose:(Galactosyl) LPS alpha1, 2-galactosyltransferase complement(4316278..4317306) Escherichia coli IAI39 7153143 YP_002410022.1 CDS waaY NC_011750.1 4317332 4318024 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92250420, 92325067, 9756860; Product type e : enzyme; lipopolysaccharide core biosynthesis protein complement(4317332..4318024) Escherichia coli IAI39 7153144 YP_002410023.1 CDS waaT NC_011750.1 4318034 4319029 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9791168, 9756860, 9792656; Product type e : enzyme; UDP-galactose:(Glucosyl) LPS alpha1, 2-galactosyltransferase complement(4318034..4319029) Escherichia coli IAI39 7153145 YP_002410024.1 CDS waaO NC_011750.1 4319046 4320062 R Evidence 1b : Function experimentally demonstrated in the studied species; Product type e : enzyme; UDP-glucose:(Glucosyl) LPS alpha1, 3-glucosyltransferase complement(4319046..4320062) Escherichia coli IAI39 7153142 YP_002410025.1 CDS waaP NC_011750.1 4320078 4320884 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101922, 92121133, 92210496, 9756860, 1732225; Product type e : enzyme; kinase that phosphorylates core heptose of lipopolysaccharide complement(4320078..4320884) Escherichia coli IAI39 7153139 YP_002410026.1 CDS waaG NC_011750.1 4320868 4321992 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92121133, 92210496, 92250420, 1447141, 1732225, 7988890; Product type e : enzyme; glucosyltransferase I complement(4320868..4321992) Escherichia coli IAI39 7153140 YP_002410027.1 CDS waaQ NC_011750.1 4321989 4323047 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9756860, 1447141, 1732225; Product type e : enzyme; lipopolysaccharide core biosynthesis protein complement(4321989..4323047) Escherichia coli IAI39 7153137 YP_002410028.1 CDS kdtA NC_011750.1 4323460 4324737 D catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 4323460..4324737 Escherichia coli IAI39 7153141 YP_002410029.1 CDS coaD NC_011750.1 4324745 4325224 D Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 4324745..4325224 Escherichia coli IAI39 7151889 YP_002410030.1 CDS mutM NC_011750.1 4325263 4326072 R Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase complement(4325263..4326072) Escherichia coli IAI39 7150974 YP_002410031.1 CDS rpmG NC_011750.1 4326170 4326337 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 complement(4326170..4326337) Escherichia coli IAI39 7152157 YP_002410032.1 CDS rpmB NC_011750.1 4326358 4326594 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(4326358..4326594) Escherichia coli IAI39 7152700 YP_002410033.1 CDS radC NC_011750.1 4326811 4327479 R Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC complement(4326811..4327479) Escherichia coli IAI39 7152695 YP_002410034.1 CDS dfp NC_011750.1 4327651 4328871 D catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 4327651..4328871 Escherichia coli IAI39 7154177 YP_002410035.1 CDS dut NC_011750.1 4328852 4329307 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 4328852..4329307 Escherichia coli IAI39 7151124 YP_002410036.1 CDS slmA NC_011750.1 4329414 4330010 D FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 4329414..4330010 Escherichia coli IAI39 7151188 YP_002410037.1 CDS ECIAI39_4160 NC_011750.1 4329863 4331026 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2466573; Product type pe : putative enzyme; putative retron-type reverse transcriptase complement(4329863..4331026) Escherichia coli IAI39 7153053 YP_002410038.1 CDS pyrE NC_011750.1 4331312 4331953 R involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase complement(4331312..4331953) Escherichia coli IAI39 7150267 YP_002410039.1 CDS rph NC_011750.1 4332019 4332759 R RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH complement(4332019..4332759) Escherichia coli IAI39 7152551 YP_002410040.1 CDS yicC NC_011750.1 4332862 4333725 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4332862..4333725 Escherichia coli IAI39 7152667 YP_002410041.1 CDS ECIAI39_4164 NC_011750.1 4333997 4334515 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4333997..4334515 Escherichia coli IAI39 7154167 YP_002410042.1 CDS ECIAI39_4165 NC_011750.1 4334534 4335754 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase 4334534..4335754 Escherichia coli IAI39 7150268 YP_002410043.1 CDS dinD NC_011750.1 4335828 4336664 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 913680, 94334998, 95095962, 1925027, 2158980, 2664418, 8002613, 8057377, 8195095; Product type cp : cell process; DNA-damage-inducible protein D 4335828..4336664 Escherichia coli IAI39 7150269 YP_002410044.1 CDS yicG NC_011750.1 4336956 4337573 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4336956..4337573 Escherichia coli IAI39 7151138 YP_002410045.1 CDS ligB NC_011750.1 4337570 4339252 R this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB complement(4337570..4339252) Escherichia coli IAI39 7154169 YP_002410046.1 CDS gmk NC_011750.1 4339510 4340133 D Essential for recycling GMP and indirectly, cGMP; guanylate kinase 4339510..4340133 Escherichia coli IAI39 7151936 YP_002410047.1 CDS rpoZ NC_011750.1 4340188 4340463 D promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 4340188..4340463 Escherichia coli IAI39 7151564 YP_002410048.1 CDS spoT NC_011750.1 4340482 4342590 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12224635, 89255395, 93266525, 94068533, 2005134, 2549050; Product type e : enzyme; bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 4340482..4342590 Escherichia coli IAI39 7152711 YP_002410049.1 CDS trmH NC_011750.1 4342597 4343286 D specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 4342597..4343286 Escherichia coli IAI39 7152887 YP_002410050.1 CDS recG NC_011750.1 4343292 4345373 D catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 4343292..4345373 Escherichia coli IAI39 7153029 YP_002410051.1 CDS gltS NC_011750.1 4345407 4346612 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91203811, 93106943, 1544582, 2017136, 2254324; Product type t : transporter; glutamate transporter complement(4345407..4346612) Escherichia coli IAI39 7152592 YP_002410052.1 CDS yicE NC_011750.1 4346892 4348283 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4346892..4348283 Escherichia coli IAI39 7151556 YP_002410053.1 CDS yicH NC_011750.1 4348404 4350113 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4348404..4350113 Escherichia coli IAI39 7154168 YP_002410054.1 CDS ECIAI39_4178 NC_011750.1 4350156 4350875 R Evidence 4 : Homologs of previously reported genes of unknown function; putative regulatory protein complement(4350156..4350875) Escherichia coli IAI39 7154170 YP_002410055.1 CDS ECIAI39_4179 NC_011750.1 4350817 4351782 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar kinase/transcriptional regulator. ATPase domain complement(4350817..4351782) Escherichia coli IAI39 7150270 YP_002410056.1 CDS ECIAI39_4180 NC_011750.1 4351797 4352657 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(4351797..4352657) Escherichia coli IAI39 7150271 YP_002410057.1 CDS ECIAI39_4181 NC_011750.1 4352738 4353589 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sugar aldolase complement(4352738..4353589) Escherichia coli IAI39 7150272 YP_002410058.1 CDS ECIAI39_4182 NC_011750.1 4353601 4354692 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative phosphotransferase system, fructose-specific IIC component complement(4353601..4354692) Escherichia coli IAI39 7150273 YP_002410059.1 CDS ECIAI39_4183 NC_011750.1 4354717 4355031 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative phosphotransferase system, fructose-specific IIB subunit complement(4354717..4355031) Escherichia coli IAI39 7150274 YP_002410060.1 CDS ECIAI39_4184 NC_011750.1 4355049 4355519 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative phosphotransferase system (PTS), fructose-specific IIA component complement(4355049..4355519) Escherichia coli IAI39 7150275 YP_002410061.1 CDS ECIAI39_4185 NC_011750.1 4355546 4357099 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative PTS system transcriptional antiterminator complement(4355546..4357099) Escherichia coli IAI39 7150276 YP_002410062.1 CDS yicI NC_011750.1 4357394 4359712 R catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase YicI complement(4357394..4359712) Escherichia coli IAI39 7150277 YP_002410063.1 CDS yicJ NC_011750.1 4359722 4361104 R may be involved in the transport of galactosides-pentoses-hexuronides; putative transporter complement(4359722..4361104) Escherichia coli IAI39 7154171 YP_002410064.1 CDS ECIAI39_4188 NC_011750.1 4361791 4362975 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative prophage integrase 4361791..4362975 Escherichia coli IAI39 7150572 YP_002410065.1 CDS ECIAI39_4189 NC_011750.1 4362996 4363151 D hypothetical protein 4362996..4363151 Escherichia coli IAI39 7150278 YP_002410066.1 CDS ECIAI39_4190 NC_011750.1 4363387 4364430 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411725; Product type pe : putative enzyme; SHI-2 pathogenicity island protein 4363387..4364430 Escherichia coli IAI39 7150279 YP_002410067.1 CDS ECIAI39_4191 NC_011750.1 4364781 4366283 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated, metal-dependent hydrolase complement(4364781..4366283) Escherichia coli IAI39 7150280 YP_002410068.1 CDS tia NC_011750.1 4366458 4367213 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8675335, 16369033; Product type f : factor; Tia invasion determinant complement(4366458..4367213) Escherichia coli IAI39 7150281 YP_002410069.1 CDS ECIAI39_4193 NC_011750.1 4367382 4367612 D Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; putative Prophage integrase (fragment) 4367382..4367612 Escherichia coli IAI39 7152983 YP_002410070.1 CDS ECIAI39_4194 NC_011750.1 4367761 4368159 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4367761..4368159 Escherichia coli IAI39 7150282 YP_002410071.1 CDS ECIAI39_4195 NC_011750.1 4369119 4370618 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Na+/H+ antiporter complement(4369119..4370618) Escherichia coli IAI39 7150283 YP_002410072.1 CDS ECIAI39_4196 NC_011750.1 4370563 4371855 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Aspartate transaminase complement(4370563..4371855) Escherichia coli IAI39 7150284 YP_002410073.1 CDS ECIAI39_4197 NC_011750.1 4372215 4372541 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 4372215..4372541 Escherichia coli IAI39 7150285 YP_002410074.1 CDS ECIAI39_4198 NC_011750.1 4372538 4373020 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 4372538..4373020 Escherichia coli IAI39 7150286 YP_002410075.1 CDS ECIAI39_4199 NC_011750.1 4373612 4375135 D Group II intron-encoded reverse transcriptase/maturase 4373612..4375135 Escherichia coli IAI39 7150287 YP_002410076.1 CDS ECIAI39_4200 NC_011750.1 4375252 4375698 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 4375252..4375698 Escherichia coli IAI39 7150548 YP_002410077.1 CDS ECIAI39_4201 NC_011750.1 4375988 4376566 D Evidence 4 : Homologs of previously reported genes of unknown function; putative transcriptional regulator 4375988..4376566 Escherichia coli IAI39 7150289 YP_002410078.1 CDS ECIAI39_4202 NC_011750.1 4376589 4377407 D Evidence 4 : Homologs of previously reported genes of unknown function; putative transcriptionnal regulator 4376589..4377407 Escherichia coli IAI39 7150290 YP_002410079.1 CDS ECIAI39_4203 NC_011750.1 4377395 4377925 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4377395..4377925 Escherichia coli IAI39 7150291 YP_002410080.1 CDS ECIAI39_4204 NC_011750.1 4377922 4378086 R hypothetical protein complement(4377922..4378086) Escherichia coli IAI39 7150292 YP_002410081.1 CDS ECIAI39_4205 NC_011750.1 4378394 4378723 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10768928, 9370271, 9573168, 11964144, 4295288; Product type ps : putative structure; putative propanediol utilization protein PduJ/pduA 4378394..4378723 Escherichia coli IAI39 7150293 YP_002410082.1 CDS ECIAI39_4206 NC_011750.1 4378741 4379025 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12007656, 8071226, 9352910, 10498708; Product type ps : putative structure; putative Propanediol utilization protein pduA/pduJ 4378741..4379025 Escherichia coli IAI39 7150294 YP_002410083.1 CDS ECIAI39_4207 NC_011750.1 4379040 4379318 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8071226, 9352910, 10498708; Product type ps : putative structure; putative propanediol utilization protein: polyhedral bodies pduJ or pduA 4379040..4379318 Escherichia coli IAI39 7150295 YP_002410084.1 CDS ECIAI39_4209 NC_011750.1 4380985 4381242 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative ethanolamine utilization protein EutN/carboxysome structural protein Ccml 4380985..4381242 Escherichia coli IAI39 7150686 YP_002410085.1 CDS ECIAI39_4211 NC_011750.1 4382403 4385825 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative Formate C-acetyltransferase (Pyruvate formate-lyase) 4382403..4385825 Escherichia coli IAI39 7150687 YP_002410086.1 CDS ECIAI39_4212 NC_011750.1 4385877 4386824 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative pyruvate formate-lyase activating enzyme 4385877..4386824 Escherichia coli IAI39 7150298 YP_002410087.1 CDS ECIAI39_4213 NC_011750.1 4386836 4387300 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative microcompartments protein 4386836..4387300 Escherichia coli IAI39 7150299 YP_002410088.1 CDS ECIAI39_4214 NC_011750.1 4387297 4387917 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4387297..4387917 Escherichia coli IAI39 7150300 YP_002410089.1 CDS ECIAI39_4215 NC_011750.1 4387929 4388594 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4387929..4388594 Escherichia coli IAI39 7150301 YP_002410090.1 CDS ECIAI39_4216 NC_011750.1 4388627 4389028 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative membrane transport protein 4388627..4389028 Escherichia coli IAI39 7150302 YP_002410091.1 CDS ECIAI39_4217 NC_011750.1 4389038 4389373 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative multidrug resistance protein 4389038..4389373 Escherichia coli IAI39 7150303 YP_002410092.1 CDS ECIAI39_4218 NC_011750.1 4389597 4389929 R Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS629 complement(4389597..4389929) Escherichia coli IAI39 7150304 YP_002410093.1 CDS dsdC NC_011750.1 4390023 4390973 R regulates the synthesis and expression of the dsdXA operon and dadA gene; DNA-binding transcriptional regulator DsdC complement(4390023..4390973) Escherichia coli IAI39 7150305 YP_002410094.1 CDS dsdX NC_011750.1 4391185 4392522 D member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; permease DsdX 4391185..4392522 Escherichia coli IAI39 7151179 YP_002410095.1 CDS dsdA NC_011750.1 4392540 4393871 D catalyzes the formation of pyruvate from serine; D-serine dehydratase 4392540..4393871 Escherichia coli IAI39 7151181 YP_002410096.1 CDS ECIAI39_4222 NC_011750.1 4394142 4394378 R Evidence 4 : Homologs of previously reported genes of unknown function; putative phage regulatory protein complement(4394142..4394378) Escherichia coli IAI39 7151177 YP_002410097.1 CDS ECIAI39_4223 NC_011750.1 4394447 4395049 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4394447..4395049) Escherichia coli IAI39 7150306 YP_002410098.1 CDS ECIAI39_4224 NC_011750.1 4395277 4395843 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4395277..4395843) Escherichia coli IAI39 7150307 YP_002410099.1 CDS ECIAI39_4225 NC_011750.1 4396663 4396749 R hypothetical protein complement(4396663..4396749) Escherichia coli IAI39 7150308 YP_002410100.1 CDS ECIAI39_4226 NC_011750.1 4397180 4398274 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 4397180..4398274 Escherichia coli IAI39 7150309 YP_002410101.1 CDS yeiM NC_011750.1 4398293 4399543 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sodium/proton nucleoside transporter complement(4398293..4399543) Escherichia coli IAI39 7150310 YP_002410102.1 CDS yeiN NC_011750.1 4399627 4400562 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4399627..4400562) Escherichia coli IAI39 7153776 YP_002410103.1 CDS ECIAI39_4229 NC_011750.1 4400555 4401517 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(4400555..4401517) Escherichia coli IAI39 7153778 YP_002410104.1 CDS ECIAI39_4230 NC_011750.1 4402026 4402478 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative hexapeptide repeat acetyltransferase complement(4402026..4402478) Escherichia coli IAI39 7150311 YP_002410105.1 CDS ECIAI39_4231 NC_011750.1 4402521 4402706 R hypothetical protein complement(4402521..4402706) Escherichia coli IAI39 7150312 YP_002410106.1 CDS ECIAI39_4232 NC_011750.1 4402999 4403730 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4402999..4403730) Escherichia coli IAI39 7150313 YP_002410107.1 CDS ECIAI39_4233 NC_011750.1 4404400 4404930 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4404400..4404930 Escherichia coli IAI39 7150314 YP_002410108.1 CDS ECIAI39_4234 NC_011750.1 4405966 4406148 R hypothetical protein complement(4405966..4406148) Escherichia coli IAI39 7150315 YP_002410109.1 CDS ECIAI39_4235 NC_011750.1 4406093 4407316 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4406093..4407316) Escherichia coli IAI39 7150316 YP_002410110.1 CDS ECIAI39_4236 NC_011750.1 4407417 4408301 D Evidence 4 : Homologs of previously reported genes of unknown function; putative GTPase 4407417..4408301 Escherichia coli IAI39 7150317 YP_002410111.1 CDS ECIAI39_4237 NC_011750.1 4409227 4410012 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4409227..4410012 Escherichia coli IAI39 7150318 YP_002410112.1 CDS ECIAI39_4238 NC_011750.1 4410018 4410251 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4410018..4410251 Escherichia coli IAI39 7150319 YP_002410113.1 CDS ECIAI39_4239 NC_011750.1 4410341 4411159 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4410341..4411159 Escherichia coli IAI39 7150320 YP_002410114.1 CDS ECIAI39_4240 NC_011750.1 4411353 4411904 D Evidence 4 : Homologs of previously reported genes of unknown function; putative antirestriction protein 4411353..4411904 Escherichia coli IAI39 7150321 YP_002410115.1 CDS yeeS NC_011750.1 4411905 4412396 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : putative factor; putative DNA repair protein; CP4-44 prophage 4411905..4412396 Escherichia coli IAI39 7150322 YP_002410116.1 CDS yeeT NC_011750.1 4412483 4412704 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 4412483..4412704 Escherichia coli IAI39 7153716 YP_002410117.1 CDS yeeU NC_011750.1 4412784 4413152 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; CP4-44 prophage YeeV-YeeU toxin-antitoxin system toxin 4412784..4413152 Escherichia coli IAI39 7153719 YP_002410118.1 CDS yeeV NC_011750.1 4413241 4413618 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; toxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage 4413241..4413618 Escherichia coli IAI39 7153722 YP_002410119.1 CDS yeeW NC_011750.1 4413615 4414037 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4413615..4414037 Escherichia coli IAI39 7153725 YP_002410120.1 CDS ECIAI39_4246 NC_011750.1 4414122 4414964 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9987116; hypothetical protein 4414122..4414964 Escherichia coli IAI39 7153728 YP_002410121.1 CDS ECIAI39_4247 NC_011750.1 4415228 4415371 D Evidence 6 : Doubtful CDS; hypothetical protein 4415228..4415371 Escherichia coli IAI39 7150323 YP_002410122.1 CDS setC NC_011750.1 4415758 4416942 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10438463, 10209755; Product type pt : putative transporter; putative sugar efflux system 4415758..4416942 Escherichia coli IAI39 7150324 YP_002410123.1 CDS yicL NC_011750.1 4417053 4417976 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4417053..4417976 Escherichia coli IAI39 7152835 YP_002410124.1 CDS nlpA NC_011750.1 4417980 4418798 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88298691, 89359178, 9914480, 3003106; Product type lp : lipoprotein; cytoplasmic membrane lipoprotein-28 complement(4417980..4418798) Escherichia coli IAI39 7154173 YP_002410125.1 CDS yicS NC_011750.1 4418937 4419299 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4418937..4419299 Escherichia coli IAI39 7152233 YP_002410126.1 CDS ECIAI39_4252 NC_011750.1 4419601 4420098 D Evidence 4 : Homologs of previously reported genes of unknown function; putative type III secretion chaperone 4419601..4420098 Escherichia coli IAI39 7154178 YP_002410127.1 CDS ECIAI39_4254 NC_011750.1 4420346 4422127 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4420346..4422127 Escherichia coli IAI39 7150325 YP_002410128.1 CDS ECIAI39_4255 NC_011750.1 4422140 4423291 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4422140..4423291 Escherichia coli IAI39 7150326 YP_002410129.1 CDS ECIAI39_4256 NC_011750.1 4423335 4424684 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4423335..4424684 Escherichia coli IAI39 7150327 YP_002410130.1 CDS ECIAI39_4257 NC_011750.1 4424887 4426584 D Activates the expression of invasion genes and activates the expression of prgHIJK which is part of the pathogenicity island 1 type III secretion system; invasion protein regulator 4424887..4426584 Escherichia coli IAI39 7150328 YP_002410131.1 CDS ECIAI39_4258 NC_011750.1 4426636 4435146 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative invasin/intimin protein complement(4426636..4435146) Escherichia coli IAI39 7150329 YP_002410132.1 CDS nepI NC_011750.1 4435348 4436580 R experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter complement(4435348..4436580) Escherichia coli IAI39 7150330 YP_002410133.1 CDS ECIAI39_4260 NC_011750.1 4436616 4436807 R Evidence 6 : Doubtful CDS; hypothetical protein complement(4436616..4436807) Escherichia coli IAI39 7154174 YP_002410134.1 CDS ECIAI39_4261 NC_011750.1 4436811 4437089 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4436811..4437089 Escherichia coli IAI39 7150331 YP_002410135.1 CDS ECIAI39_4262 NC_011750.1 4437102 4437425 D Evidence 4 : Homologs of previously reported genes of unknown function; putative transcriptional regulator 4437102..4437425 Escherichia coli IAI39 7150332 YP_002410136.1 CDS yicN NC_011750.1 4437541 4437993 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4437541..4437993) Escherichia coli IAI39 7150333 YP_002410137.1 CDS yicO NC_011750.1 4438046 4439380 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative xanthine/uracil permease complement(4438046..4439380) Escherichia coli IAI39 7154175 YP_002410138.1 CDS ade NC_011750.1 4439555 4441321 D catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 4439555..4441321 Escherichia coli IAI39 7154176 YP_002410139.1 CDS uhpT NC_011750.1 4441368 4442759 R cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter complement(4441368..4442759) Escherichia coli IAI39 7150684 YP_002410140.1 CDS uhpC NC_011750.1 4442897 4444216 R membrane protein regulates uhpT expression; regulatory protein UhpC complement(4442897..4444216) Escherichia coli IAI39 7153089 YP_002410141.1 CDS uhpB NC_011750.1 4444226 4445728 R Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB complement(4444226..4445728) Escherichia coli IAI39 7153088 YP_002410142.1 CDS uhpA NC_011750.1 4445728 4446318 R response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; DNA-binding transcriptional activator UhpA complement(4445728..4446318) Escherichia coli IAI39 7153087 YP_002410143.1 CDS ECIAI39_4270 NC_011750.1 4446480 4447982 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4446480..4447982) Escherichia coli IAI39 7153086 YP_002410144.1 CDS ECIAI39_4271 NC_011750.1 4448197 4449492 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4448197..4449492) Escherichia coli IAI39 7150334 YP_002410145.1 CDS ilvN NC_011750.1 4449743 4450033 R with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit complement(4449743..4450033) Escherichia coli IAI39 7150335 YP_002410146.1 CDS ilvB NC_011750.1 4450037 4451725 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2989782, 85242083, 92380929, 2989781; Product type e : enzyme; acetolactate synthase catalytic subunit complement(4450037..4451725) Escherichia coli IAI39 7151773 YP_002410147.1 CDS ECIAI39_4274 NC_011750.1 4451709 4452206 D Evidence 6 : Doubtful CDS; hypothetical protein 4451709..4452206 Escherichia coli IAI39 7151764 YP_002410148.1 CDS ivbL NC_011750.1 4451831 4451929 R Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; ilvB operon leader peptide complement(4451831..4451929) Escherichia coli IAI39 7150336 YP_002410149.1 CDS ECIAI39_4275 NC_011750.1 4452203 4452361 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4452203..4452361 Escherichia coli IAI39 7151861 YP_002410150.1 CDS ECIAI39_4276 NC_011750.1 4452494 4452583 D Evidence 4 : Homologs of previously reported genes of unknown function; toxic peptide TisB 4452494..4452583 Escherichia coli IAI39 7150337 YP_002410151.1 CDS emrD NC_011750.1 4452863 4454047 D multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 4452863..4454047 Escherichia coli IAI39 7150338 YP_002410152.1 CDS yidF NC_011750.1 4454055 4454552 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(4454055..4454552) Escherichia coli IAI39 7151216 YP_002410153.1 CDS yidG NC_011750.1 4454549 4454911 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4454549..4454911) Escherichia coli IAI39 7154184 YP_002410154.1 CDS yidH NC_011750.1 4454901 4455248 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4454901..4455248) Escherichia coli IAI39 7154185 YP_002410155.1 CDS yidJ NC_011750.1 4455308 4456801 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative sulfatase/phosphatase complement(4455308..4456801) Escherichia coli IAI39 7154186 YP_002410156.1 CDS yidK NC_011750.1 4456798 4458513 R uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function; putative symporter YidK complement(4456798..4458513) Escherichia coli IAI39 7154187 YP_002410157.1 CDS yidL NC_011750.1 4458650 4459573 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4458650..4459573 Escherichia coli IAI39 7154188 YP_002410158.1 CDS ECIAI39_4284 NC_011750.1 4459570 4460892 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; 6-phospho-glucosidase complement(4459570..4460892) Escherichia coli IAI39 7154189 YP_002410159.1 CDS ECIAI39_4285 NC_011750.1 4460892 4462769 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative PTS system alpha-glucoside-specific EIICB component complement(4460892..4462769) Escherichia coli IAI39 7150339 YP_002410160.1 CDS yidP NC_011750.1 4462804 4463520 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 4462804..4463520 Escherichia coli IAI39 7150340 YP_002410161.1 CDS yidE NC_011750.1 4463517 4465178 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1356969; Product type pt : putative transporter; hypothetical protein complement(4463517..4465178) Escherichia coli IAI39 7154190 YP_002410162.1 CDS ibpB NC_011750.1 4465374 4465802 R 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB complement(4465374..4465802) Escherichia coli IAI39 7154183 YP_002410163.1 CDS ibpA NC_011750.1 4465914 4466327 R with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA complement(4465914..4466327) Escherichia coli IAI39 7151745 YP_002410164.1 CDS yidQ NC_011750.1 4466633 4466965 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4466633..4466965 Escherichia coli IAI39 7151744 YP_002410165.1 CDS yidR NC_011750.1 4466967 4468181 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4466967..4468181) Escherichia coli IAI39 7154191 YP_002410166.1 CDS cbrA NC_011750.1 4468282 4469346 D FAD/NAD(P)-binding domain; putative oxidoreductase 4468282..4469346 Escherichia coli IAI39 7154192 YP_002410167.1 CDS dgoT NC_011750.1 4469343 4470635 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type t : transporter; D-galactonate transporter complement(4469343..4470635) Escherichia coli IAI39 7150907 YP_002410168.1 CDS dgoD NC_011750.1 4470755 4471903 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type e : enzyme; galactonate dehydratase complement(4470755..4471903) Escherichia coli IAI39 7151130 YP_002410169.1 CDS dgoA NC_011750.1 4471900 4472517 R catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase complement(4471900..4472517) Escherichia coli IAI39 7151127 YP_002410170.1 CDS dgoK NC_011750.1 4472501 4473379 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type e : enzyme; 2-oxo-3-deoxygalactonate kinase complement(4472501..4473379) Escherichia coli IAI39 7151126 YP_002410171.1 CDS dgoR NC_011750.1 4473376 4474065 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 79020349; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(4473376..4474065) Escherichia coli IAI39 7151128 YP_002410172.1 CDS yidX NC_011750.1 4474226 4474999 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 4474226..4474999 Escherichia coli IAI39 7151129 YP_002410173.1 CDS yidA NC_011750.1 4475043 4475855 R YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase complement(4475043..4475855) Escherichia coli IAI39 7154193 YP_002410174.1 CDS yidB NC_011750.1 4475970 4476368 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4475970..4476368) Escherichia coli IAI39 7154179 YP_002410175.1 CDS ECIAI39_4301 NC_011750.1 4476539 4477261 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group complement(4476539..4477261) Escherichia coli IAI39 7154180 YP_002410176.1 CDS ECIAI39_4302 NC_011750.1 4477366 4477896 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 complement(4477366..4477896) Escherichia coli IAI39 7150341 YP_002410177.1 CDS gyrB NC_011750.1 4478043 4480457 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B complement(4478043..4480457) Escherichia coli IAI39 7150342 YP_002410178.1 CDS recF NC_011750.1 4480486 4481559 R Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F complement(4480486..4481559) Escherichia coli IAI39 7151606 YP_002410179.1 CDS dnaN NC_011750.1 4481559 4482659 R binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta complement(4481559..4482659) Escherichia coli IAI39 7152591 YP_002410180.1 CDS dnaA NC_011750.1 4482664 4484067 R binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein complement(4482664..4484067) Escherichia coli IAI39 7151160 YP_002410181.1 CDS rpmH NC_011750.1 4484674 4484814 D in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 4484674..4484814 Escherichia coli IAI39 7151153 YP_002410182.1 CDS rnpA NC_011750.1 4484831 4485190 D protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 4484831..4485190 Escherichia coli IAI39 7152701 YP_002410183.1 CDS yidD NC_011750.1 4485154 4485411 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4485154..4485411 Escherichia coli IAI39 7152661 YP_002410184.1 CDS yidC NC_011750.1 4485414 4487060 D functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; putative inner membrane protein translocase component YidC 4485414..4487060 Escherichia coli IAI39 7154182 YP_002410185.1 CDS trmE NC_011750.1 4487166 4488530 D in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 4487166..4488530 Escherichia coli IAI39 7154181 YP_002410186.1 CDS tnaC NC_011750.1 4488772 4488846 D Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; tryptophanase leader peptide 4488772..4488846 Escherichia coli IAI39 7153028 YP_002410187.1 CDS tnaA NC_011750.1 4489066 4490481 D tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 4489066..4490481 Escherichia coli IAI39 7152995 YP_002410188.1 CDS tnaB NC_011750.1 4490573 4491820 D tryptophan transporter of low affinity; tryptophan permease TnaB 4490573..4491820 Escherichia coli IAI39 7152993 YP_002410189.1 CDS mdtL NC_011750.1 4491953 4493128 D Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 4491953..4493128 Escherichia coli IAI39 7152994 YP_002410190.1 CDS yidZ NC_011750.1 4493103 4494062 D Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ 4493103..4494062 Escherichia coli IAI39 7152039 YP_002410191.1 CDS yieE NC_011750.1 4494207 4494968 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative phosphopantetheinyl transferase 4494207..4494968 Escherichia coli IAI39 7154194 YP_002410192.1 CDS yieF NC_011750.1 4494990 4495556 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14766567; Product type e : enzyme; chromate reductase, Class I, flavoprotein 4494990..4495556 Escherichia coli IAI39 7154195 YP_002410193.1 CDS yieG NC_011750.1 4495610 4496947 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4495610..4496947) Escherichia coli IAI39 7154196 YP_002410194.1 CDS yieH NC_011750.1 4497114 4497779 D YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 4497114..4497779 Escherichia coli IAI39 7154197 YP_002410195.1 CDS ECIAI39_4320 NC_011750.1 4497916 4500342 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4497916..4500342) Escherichia coli IAI39 7154198 YP_002410196.1 CDS ECIAI39_4321 NC_011750.1 4500625 4501812 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4500625..4501812 Escherichia coli IAI39 7150343 YP_002410197.1 CDS ECIAI39_4322 NC_011750.1 4501988 4502137 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4501988..4502137 Escherichia coli IAI39 7150344 YP_002410198.1 CDS ECIAI39_4323 NC_011750.1 4502282 4504792 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4502282..4504792) Escherichia coli IAI39 7150345 YP_002410199.1 CDS phoU NC_011750.1 4505198 4505923 R regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU complement(4505198..4505923) Escherichia coli IAI39 7150346 YP_002410200.1 CDS pstB NC_011750.1 4505938 4506711 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(4505938..4506711) Escherichia coli IAI39 7152416 YP_002410201.1 CDS pstA NC_011750.1 4506802 4507692 R Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PtsA complement(4506802..4507692) Escherichia coli IAI39 7152510 YP_002410202.1 CDS pstC NC_011750.1 4507692 4508651 R part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PstC complement(4507692..4508651) Escherichia coli IAI39 7152509 YP_002410203.1 CDS pstS NC_011750.1 4508738 4509778 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90133909, 2215649, 6321434, 6365894, 9228942, 9298646, 9671506; Product type t : transporter; phosphate ABC transporter periplasmic substrate-binding protein PstS complement(4508738..4509778) Escherichia coli IAI39 7152511 YP_002410204.1 CDS lpfD NC_011750.1 4510026 4511096 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12438351, 7721701, 16128397; Product type ps : putative structure; putative fimbrial protein LpfD; putative adhesin complement(4510026..4511096) Escherichia coli IAI39 7152512 YP_002410205.1 CDS lpfC NC_011750.1 4511107 4513629 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7721701, 16128397; Product type pt : putative transporter; putative fimbrial usher complement(4511107..4513629) Escherichia coli IAI39 7151960 YP_002410206.1 CDS lfpB NC_011750.1 4513654 4514385 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16128397, 12438351; Product type pc : putative carrier; putative fimbrial chaperone protein complement(4513654..4514385) Escherichia coli IAI39 7151959 YP_002410207.1 CDS lpfA NC_011750.1 4514433 4515005 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16125910, 12438351; Product type ps : putative structure; putative major fimbrial subunit complement(4514433..4515005) Escherichia coli IAI39 7151932 YP_002410208.1 CDS glmS NC_011750.1 4515313 4517142 R Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase complement(4515313..4517142) Escherichia coli IAI39 7151958 YP_002410209.1 CDS glmU NC_011750.1 4517304 4518674 R forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase complement(4517304..4518674) Escherichia coli IAI39 7151521 YP_002410210.1 CDS atpC NC_011750.1 4519023 4519442 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon complement(4519023..4519442) Escherichia coli IAI39 7151522 YP_002410211.1 CDS atpD NC_011750.1 4519463 4520845 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta complement(4519463..4520845) Escherichia coli IAI39 7150823 YP_002410212.1 CDS atpG NC_011750.1 4520872 4521735 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma complement(4520872..4521735) Escherichia coli IAI39 7150824 YP_002410213.1 CDS atpA NC_011750.1 4521786 4523327 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha complement(4521786..4523327) Escherichia coli IAI39 7150827 YP_002410214.1 CDS atpH NC_011750.1 4523340 4523873 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta complement(4523340..4523873) Escherichia coli IAI39 7150821 YP_002410215.1 CDS atpF NC_011750.1 4523888 4524358 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B complement(4523888..4524358) Escherichia coli IAI39 7150828 YP_002410216.1 CDS atpE NC_011750.1 4524420 4524659 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C complement(4524420..4524659) Escherichia coli IAI39 7150826 YP_002410217.1 CDS atpB NC_011750.1 4524706 4525521 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A complement(4524706..4525521) Escherichia coli IAI39 7150825 YP_002410218.1 CDS atpI NC_011750.1 4525530 4525910 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I complement(4525530..4525910) Escherichia coli IAI39 7150822 YP_002410219.1 CDS gidB NC_011750.1 4526527 4527150 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(4526527..4527150) Escherichia coli IAI39 7150829 YP_002410220.1 CDS gidA NC_011750.1 4527214 4529103 R GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA complement(4527214..4529103) Escherichia coli IAI39 7151504 YP_002410221.1 CDS mioC NC_011750.1 4529482 4529925 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(4529482..4529925) Escherichia coli IAI39 7151503 YP_002410222.1 CDS asnC NC_011750.1 4530015 4530473 R transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC complement(4530015..4530473) Escherichia coli IAI39 7152086 YP_002410223.1 CDS asnA NC_011750.1 4530625 4531617 D catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 4530625..4531617 Escherichia coli IAI39 7150804 YP_002410224.1 CDS yieM NC_011750.1 4531622 4533073 R contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein complement(4531622..4533073) Escherichia coli IAI39 7150802 YP_002410225.1 CDS ravA NC_011750.1 4533067 4534563 R interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA complement(4533067..4534563) Escherichia coli IAI39 7154199 YP_002410226.1 CDS insG NC_011750.1 4534719 4536065 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase, IS4 4534719..4536065 Escherichia coli IAI39 7152567 YP_002410227.1 CDS trkD NC_011750.1 4536224 4538092 D Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 4536224..4538092 Escherichia coli IAI39 7151819 YP_002410228.1 CDS rbsD NC_011750.1 4538259 4538678 D cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 4538259..4538678 Escherichia coli IAI39 7153023 YP_002410229.1 CDS rbsA NC_011750.1 4538686 4540191 D with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP binding protein 4538686..4540191 Escherichia coli IAI39 7152574 YP_002410230.1 CDS rbsC NC_011750.1 4540196 4541161 D functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 4540196..4541161 Escherichia coli IAI39 7152571 YP_002410231.1 CDS rbsB NC_011750.1 4541186 4542076 D periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 4541186..4542076 Escherichia coli IAI39 7152573 YP_002410232.1 CDS rbsK NC_011750.1 4542202 4543131 D catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 4542202..4543131 Escherichia coli IAI39 7152572 YP_002410233.1 CDS rbsR NC_011750.1 4543135 4544127 D DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 4543135..4544127 Escherichia coli IAI39 7152575 YP_002410234.1 CDS hsrA NC_011750.1 4544093 4545520 R Evidence 2b : Function of strongly homologous gene; PubMedId : 20218988, 12107133; Product type t : transporter; multidrug or homocysteine efflux system complement(4544093..4545520) Escherichia coli IAI39 7152576 YP_002410235.1 CDS yieP NC_011750.1 4545543 4546235 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator complement(4545543..4546235) Escherichia coli IAI39 7151685 YP_002410236.1 CDS murB NC_011750.1 4551902 4552930 D catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 4551902..4552930 Escherichia coli IAI39 7150516 YP_002410237.1 CDS birA NC_011750.1 4552927 4553892 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 4552927..4553892 Escherichia coli IAI39 7152146 YP_002410238.1 CDS coaA NC_011750.1 4553921 4554871 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(4553921..4554871) Escherichia coli IAI39 7150869 YP_002410239.1 CDS tufB NC_011750.1 4555789 4556973 D EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4555789..4556973 Escherichia coli IAI39 7150578 YP_002410240.1 CDS secE NC_011750.1 4557203 4557586 D forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 4557203..4557586 Escherichia coli IAI39 7153055 YP_002410241.1 CDS nusG NC_011750.1 4557588 4558133 D Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 4557588..4558133 Escherichia coli IAI39 7152821 YP_002410242.1 CDS rplK NC_011750.1 4558292 4558720 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 4558292..4558720 Escherichia coli IAI39 7152286 YP_002410243.1 CDS rplA NC_011750.1 4558724 4559428 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 4558724..4559428 Escherichia coli IAI39 7152679 YP_002410244.1 CDS rplJ NC_011750.1 4559720 4560217 D binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 4559720..4560217 Escherichia coli IAI39 7152671 YP_002410245.1 CDS rplL NC_011750.1 4560284 4560649 D present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 4560284..4560649 Escherichia coli IAI39 7152678 YP_002410246.1 CDS rpoB NC_011750.1 4560969 4564997 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 4560969..4564997 Escherichia coli IAI39 7152680 YP_002410247.1 CDS rpoC NC_011750.1 4565074 4569297 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 4565074..4569297 Escherichia coli IAI39 7152704 YP_002410248.1 CDS ECIAI39_4374 NC_011750.1 4569554 4570771 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative carbohydrate kinase 4569554..4570771 Escherichia coli IAI39 7152705 YP_002410249.1 CDS ECIAI39_4375 NC_011750.1 4570773 4571399 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease of transport system 4570773..4571399 Escherichia coli IAI39 7150347 YP_002410250.1 CDS ECIAI39_4376 NC_011750.1 4571451 4572272 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease of a carbohydrate transport system 4571451..4572272 Escherichia coli IAI39 7150348 YP_002410251.1 CDS ECIAI39_4377 NC_011750.1 4572232 4574919 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4572232..4574919 Escherichia coli IAI39 7150349 YP_002410252.1 CDS ECIAI39_4378 NC_011750.1 4574950 4575600 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(4574950..4575600) Escherichia coli IAI39 7150350 YP_002410253.1 CDS thiH NC_011750.1 4575918 4577051 R in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH complement(4575918..4577051) Escherichia coli IAI39 7150351 YP_002410254.1 CDS thiG NC_011750.1 4577048 4577818 R functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase complement(4577048..4577818) Escherichia coli IAI39 7152970 YP_002410255.1 CDS thiS NC_011750.1 4577820 4578020 R with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS complement(4577820..4578020) Escherichia coli IAI39 7152969 YP_002410256.1 CDS thiF NC_011750.1 4578004 4578759 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8432721, 94089392, 98298179, 10082377, 9632726; Product type e : enzyme; thiamin (thiazole moiety) biosynthesis protein complement(4578004..4578759) Escherichia coli IAI39 7152976 YP_002410257.1 CDS thiE NC_011750.1 4578752 4579387 R catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase complement(4578752..4579387) Escherichia coli IAI39 7152968 YP_002410258.1 CDS thiC NC_011750.1 4579387 4581282 R required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC complement(4579387..4581282) Escherichia coli IAI39 7152967 YP_002410259.1 CDS rsd NC_011750.1 4581515 4581991 R binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor complement(4581515..4581991) Escherichia coli IAI39 7150549 YP_002410260.1 CDS nudC NC_011750.1 4582086 4582859 D can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 4582086..4582859 Escherichia coli IAI39 7152737 YP_002410261.1 CDS hemE NC_011750.1 4582899 4583963 D catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 4582899..4583963 Escherichia coli IAI39 7152263 YP_002410262.1 CDS nfi NC_011750.1 4583973 4584644 D Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 4583973..4584644 Escherichia coli IAI39 7151628 YP_002410263.1 CDS yjaG NC_011750.1 4584687 4585277 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4584687..4585277 Escherichia coli IAI39 7152213 YP_002410264.1 CDS hupA NC_011750.1 4585464 4585736 D histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 4585464..4585736 Escherichia coli IAI39 7154252 YP_002410265.1 CDS yjaH NC_011750.1 4585749 4586444 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4585749..4586444 Escherichia coli IAI39 7151691 YP_002410266.1 CDS zraP NC_011750.1 4586446 4587006 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98362023, 9694902; Product type pf : putative factor; zinc resistance protein complement(4586446..4587006) Escherichia coli IAI39 7154253 YP_002410267.1 CDS zraS NC_011750.1 4587103 4588479 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21140164, 89327164, 92255260, 11243806, 2666400; Product type r : regulator; sensor protein ZraS 4587103..4588479 Escherichia coli IAI39 7154595 YP_002410268.1 CDS zraR NC_011750.1 4588476 4589801 D DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 4588476..4589801 Escherichia coli IAI39 7154597 YP_002410269.1 CDS purD NC_011750.1 4589798 4591087 R catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase complement(4589798..4591087) Escherichia coli IAI39 7154596 YP_002410270.1 CDS purH NC_011750.1 4591099 4592688 R involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase complement(4591099..4592688) Escherichia coli IAI39 7152526 YP_002410271.1 CDS ECIAI39_4397 NC_011750.1 4592642 4592791 R hypothetical protein complement(4592642..4592791) Escherichia coli IAI39 7152529 YP_002410272.1 CDS yjaB NC_011750.1 4598433 4598876 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; hypothetical protein complement(4598433..4598876) Escherichia coli IAI39 7150517 YP_002410273.1 CDS metA NC_011750.1 4599033 4599962 D catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 4599033..4599962 Escherichia coli IAI39 7154251 YP_002410274.1 CDS aceB NC_011750.1 4600231 4601832 D Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 4600231..4601832 Escherichia coli IAI39 7152050 YP_002410275.1 CDS aceA NC_011750.1 4601862 4603166 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91295197, 92112731, 92353108, 2836370, 3049537, 3060852, 3276689, 3290857, 3291954, 7826335; Product type e : enzyme; isocitrate lyase 4601862..4603166 Escherichia coli IAI39 7150661 YP_002410276.1 CDS ECIAI39_4402 NC_011750.1 4603252 4603782 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 4603252..4603782 Escherichia coli IAI39 7150660 YP_002410277.1 CDS ECIAI39_4403 NC_011750.1 4603887 4604609 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 4603887..4604609 Escherichia coli IAI39 7150353 YP_002410278.1 CDS aceK NC_011750.1 4604786 4606510 D catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol; bifunctional isocitrate dehydrogenase kinase/phosphatase protein 4604786..4606510 Escherichia coli IAI39 7150354 YP_002410279.1 CDS iclR NC_011750.1 4606527 4607351 R regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; transcriptional repressor IclR complement(4606527..4607351) Escherichia coli IAI39 7150664 YP_002410280.1 CDS metH NC_011750.1 4607551 4611234 D one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 4607551..4611234 Escherichia coli IAI39 7151752 YP_002410281.1 CDS ECIAI39_4407 NC_011750.1 4611288 4611614 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4611288..4611614 Escherichia coli IAI39 7152056 YP_002410282.1 CDS ECIAI39_4408 NC_011750.1 4611657 4612106 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4611657..4612106 Escherichia coli IAI39 7150355 YP_002410283.1 CDS yjbB NC_011750.1 4612277 4613908 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4612277..4613908 Escherichia coli IAI39 7150356 YP_002410284.1 CDS pepE NC_011750.1 4613998 4614687 R alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E complement(4613998..4614687) Escherichia coli IAI39 7154255 YP_002410285.1 CDS ECIAI39_4411 NC_011750.1 4614810 4615622 R catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(4614810..4615622) Escherichia coli IAI39 7152364 YP_002410286.1 CDS ECIAI39_4412 NC_011750.1 4615615 4616856 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968, 7652212; Product type e : enzyme; L-sorbose 1-phosphate reductase complement(4615615..4616856) Escherichia coli IAI39 7150357 YP_002410287.1 CDS ECIAI39_4413 NC_011750.1 4616896 4617750 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968, 7700234; Product type t : transporter; sorbose permease IID component complement(4616896..4617750) Escherichia coli IAI39 7150358 YP_002410288.1 CDS ECIAI39_4414 NC_011750.1 4617731 4618528 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968, 7700234; Product type t : transporter; sorbose permease IIC component (PTS system) complement(4617731..4618528) Escherichia coli IAI39 7150359 YP_002410289.1 CDS ECIAI39_4415 NC_011750.1 4618594 4619088 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968, 7700234, 12662934; Product type t : transporter; sorbose-specific phosphotransferase enzyme IIB component (PTS system) complement(4618594..4619088) Escherichia coli IAI39 7150360 YP_002410290.1 CDS ECIAI39_4416 NC_011750.1 4619088 4619495 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968; Product type t : transporter; sorbose-specific phosphotransferase enzyme IIA component (PTS system) complement(4619088..4619495) Escherichia coli IAI39 7150361 YP_002410291.1 CDS ECIAI39_4417 NC_011750.1 4619505 4620311 R Converts D-sorbitol-dphosphate to D-fructose-6-phosphate; sorbitol-6-phosphate 2-dehydrogenase complement(4619505..4620311) Escherichia coli IAI39 7150362 YP_002410292.1 CDS ECIAI39_4418 NC_011750.1 4620381 4621379 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7947968; Product type r : regulator; sorbitol/sorbose operon activator complement(4620381..4621379) Escherichia coli IAI39 7150363 YP_002410293.1 CDS yjbC NC_011750.1 4621592 4622464 D catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 4621592..4622464 Escherichia coli IAI39 7150364 YP_002410294.1 CDS yjbD NC_011750.1 4622465 4622737 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4622465..4622737) Escherichia coli IAI39 7154256 YP_002410295.1 CDS ECIAI39_4422 NC_011750.1 4623266 4624393 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4623266..4624393 Escherichia coli IAI39 7150365 YP_002410296.1 CDS ECIAI39_4423 NC_011750.1 4624390 4625190 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4624390..4625190 Escherichia coli IAI39 7150366 YP_002410297.1 CDS ECIAI39_4424 NC_011750.1 4625205 4625660 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4625205..4625660) Escherichia coli IAI39 7150367 YP_002410298.1 CDS ECIAI39_4425 NC_011750.1 4625657 4626364 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative phage tail fiber assembly protein complement(4625657..4626364) Escherichia coli IAI39 7150368 YP_002410299.1 CDS ECIAI39_4426 NC_011750.1 4626361 4627941 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative side tail phage protein complement(4626361..4627941) Escherichia coli IAI39 7150369 YP_002410300.1 CDS ECIAI39_4427 NC_011750.1 4627944 4628675 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative phage tail protein complement(4627944..4628675) Escherichia coli IAI39 7150370 YP_002410301.1 CDS ECIAI39_4428 NC_011750.1 4628653 4629768 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative phage baseplate protein complement(4628653..4629768) Escherichia coli IAI39 7150371 YP_002410302.1 CDS ECIAI39_4429 NC_011750.1 4629759 4630118 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative phage baseplate protein complement(4629759..4630118) Escherichia coli IAI39 7150372 YP_002410303.1 CDS ECIAI39_4430 NC_011750.1 4630217 4630918 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7483254; Product type ps : putative structure; putative phage baseplate component complement(4630217..4630918) Escherichia coli IAI39 7150373 YP_002410304.1 CDS ECIAI39_4431 NC_011750.1 4630928 4631968 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative control protein for phage late genes expression complement(4630928..4631968) Escherichia coli IAI39 7150374 YP_002410305.1 CDS ECIAI39_4432 NC_011750.1 4631956 4632168 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative phage tail protein complement(4631956..4632168) Escherichia coli IAI39 7150375 YP_002410306.1 CDS ECIAI39_4433 NC_011750.1 4632165 4633118 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; hypothetical protein complement(4632165..4633118) Escherichia coli IAI39 7150376 YP_002410307.1 CDS ECIAI39_4434 NC_011750.1 4633118 4635493 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure; putative phage tail protein complement(4633118..4635493) Escherichia coli IAI39 7150377 YP_002410308.1 CDS ECIAI39_4435 NC_011750.1 4635683 4636000 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4635683..4636000) Escherichia coli IAI39 7150378 YP_002410309.1 CDS ECIAI39_4436 NC_011750.1 4636051 4636575 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage tail core protein complement(4636051..4636575) Escherichia coli IAI39 7150379 YP_002410310.1 CDS ECIAI39_4437 NC_011750.1 4636575 4638005 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1825255; Product type ps : putative structure; putative phage tail sheath protein complement(4636575..4638005) Escherichia coli IAI39 7150380 YP_002410311.1 CDS ECIAI39_4438 NC_011750.1 4637989 4638186 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4637989..4638186) Escherichia coli IAI39 7150381 YP_002410312.1 CDS ECIAI39_4439 NC_011750.1 4638183 4638638 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4638183..4638638) Escherichia coli IAI39 7150382 YP_002410313.1 CDS ECIAI39_4440 NC_011750.1 4638785 4639099 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative inner membrane protein complement(4638785..4639099) Escherichia coli IAI39 7150383 YP_002410314.1 CDS ECIAI39_4441 NC_011750.1 4639112 4639795 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative soluble lytic murein transglycosylase complement(4639112..4639795) Escherichia coli IAI39 7150384 YP_002410315.1 CDS ECIAI39_4442 NC_011750.1 4639720 4640007 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component; putative inner membrane protein complement(4639720..4640007) Escherichia coli IAI39 7150385 YP_002410316.1 CDS ECIAI39_4443 NC_011750.1 4640346 4641566 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase complement(4640346..4641566) Escherichia coli IAI39 7150386 YP_002410317.1 CDS ECIAI39_4444 NC_011750.1 4641585 4642103 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4641585..4642103) Escherichia coli IAI39 7150387 YP_002410318.1 CDS ECIAI39_4445 NC_011750.1 4642437 4642784 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7715460; Product type pr : putative regulator; putative transcriptional regulator 4642437..4642784 Escherichia coli IAI39 7150388 YP_002410319.1 CDS lysC NC_011750.1 4642839 4644188 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase III complement(4642839..4644188) Escherichia coli IAI39 7150389 YP_002410320.1 CDS pgi NC_011750.1 4644713 4646362 D functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 4644713..4646362 Escherichia coli IAI39 7150550 YP_002410321.1 CDS ECIAI39_4448 NC_011750.1 4646697 4646945 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4646697..4646945) Escherichia coli IAI39 7152381 YP_002410322.1 CDS yjbF NC_011750.1 4647072 4647710 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; putative lipoprotein 4647072..4647710 Escherichia coli IAI39 7150390 YP_002410323.1 CDS yjbG NC_011750.1 4647707 4648444 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4647707..4648444 Escherichia coli IAI39 7154258 YP_002410324.1 CDS yjbH NC_011750.1 4648444 4650540 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative porin 4648444..4650540 Escherichia coli IAI39 7154259 YP_002410325.1 CDS yjbA NC_011750.1 4651079 4651489 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10986267; Product type pm : putative membrane component; phosphate-starvation-inducible protein PsiE 4651079..4651489 Escherichia coli IAI39 7154260 YP_002410326.1 CDS malG NC_011750.1 4651583 4652473 R with MalKFE is involved in the transport of maltose into the cell; maltose transporter permease complement(4651583..4652473) Escherichia coli IAI39 7154254 YP_002410327.1 CDS malF NC_011750.1 4652488 4654032 R with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein complement(4652488..4654032) Escherichia coli IAI39 7151997 YP_002410328.1 CDS malE NC_011750.1 4654186 4655376 R functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter periplasmic protein complement(4654186..4655376) Escherichia coli IAI39 7151996 YP_002410329.1 CDS malK NC_011750.1 4655741 4656856 D with malEFG is involved in import of maltose/maltodextrin; maltose/maltodextrin transporter ATP-binding protein 4655741..4656856 Escherichia coli IAI39 7151995 YP_002410330.1 CDS lamB NC_011750.1 4656928 4658268 D porin involved in the transport of maltose and maltodextrins; maltoporin 4656928..4658268 Escherichia coli IAI39 7151999 YP_002410331.1 CDS malM NC_011750.1 4658511 4659431 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87141162, 2434655, 6086106; Product type pt : putative transporter; maltose regulon periplasmic protein 4658511..4659431 Escherichia coli IAI39 7151916 YP_002410332.1 CDS yjbI NC_011750.1 4659659 4661239 D in E. coli, some yjbl mutations have been reported as suppressors of dnaG mutations; hypothetical protein 4659659..4661239 Escherichia coli IAI39 7152000 YP_002410333.1 CDS ubiC NC_011750.1 4661462 4661959 D catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 4661462..4661959 Escherichia coli IAI39 7154261 YP_002410334.1 CDS ubiA NC_011750.1 4661972 4662844 D catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 4661972..4662844 Escherichia coli IAI39 7153070 YP_002410335.1 CDS plsB NC_011750.1 4662999 4665422 R PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase complement(4662999..4665422) Escherichia coli IAI39 7153068 YP_002410336.1 CDS dgkA NC_011750.1 4665593 4665961 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10220339, 6257698, 86278195, 88111690, 2984194, 6309817, 8071224; Product type e : enzyme; diacylglycerol kinase 4665593..4665961 Escherichia coli IAI39 7152427 YP_002410337.1 CDS lexA NC_011750.1 4666071 4666679 D Represses a number of genes involved in the response to DNA damage; LexA repressor 4666071..4666679 Escherichia coli IAI39 7151125 YP_002410338.1 CDS dinF NC_011750.1 4666698 4668077 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87165788; Product type cp : cell process; DNA-damage-inducible SOS response protein 4666698..4668077 Escherichia coli IAI39 7151931 YP_002410339.1 CDS yjbJ NC_011750.1 4668193 4668402 D unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; putative stress-response protein 4668193..4668402 Escherichia coli IAI39 7151139 YP_002410340.1 CDS zur NC_011750.1 4668444 4668959 R Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor complement(4668444..4668959) Escherichia coli IAI39 7154262 YP_002410341.1 CDS ECIAI39_4468 NC_011750.1 4669277 4670281 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4669277..4670281 Escherichia coli IAI39 7154599 YP_002410342.1 CDS yjbN NC_011750.1 4670643 4671680 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566; Product type e : enzyme; tRNA-dihydrouridine synthase A 4670643..4671680 Escherichia coli IAI39 7150391 YP_002410343.1 CDS pspG NC_011750.1 4671604 4672056 D coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 4671604..4672056 Escherichia coli IAI39 7154263 YP_002410344.1 CDS qor NC_011750.1 4672222 4673331 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94089392, 7602590; Product type e : enzyme; quinone oxidoreductase, NADPH-dependent complement(4672222..4673331) Escherichia coli IAI39 7154264 YP_002410345.1 CDS dnaB NC_011750.1 4673306 4674721 D unwinds double stranded DNA; replicative DNA helicase 4673306..4674721 Escherichia coli IAI39 7152557 YP_002410346.1 CDS alr NC_011750.1 4674774 4675853 D converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 4674774..4675853 Escherichia coli IAI39 7151154 YP_002410347.1 CDS tyrB NC_011750.1 4676106 4677299 D catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 4676106..4677299 Escherichia coli IAI39 7150718 YP_002410348.1 CDS ECIAI39_4475 NC_011750.1 4677522 4678061 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4677522..4678061) Escherichia coli IAI39 7153063 YP_002410349.1 CDS aphA NC_011750.1 4678426 4679139 D Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 4678426..4679139 Escherichia coli IAI39 7150392 YP_002410350.1 CDS yjbQ NC_011750.1 4679250 4679666 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11972052; hypothetical protein 4679250..4679666 Escherichia coli IAI39 7150741 YP_002410351.1 CDS yjbR NC_011750.1 4679670 4680026 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4679670..4680026 Escherichia coli IAI39 7154265 YP_002410352.1 CDS uvrA NC_011750.1 4680061 4682883 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A complement(4680061..4682883) Escherichia coli IAI39 7154266 YP_002410353.1 CDS ssb NC_011750.1 4683138 4683674 D binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 4683138..4683674 Escherichia coli IAI39 7153113 YP_002410354.1 CDS yjcB NC_011750.1 4683773 4684054 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4683773..4684054) Escherichia coli IAI39 7152902 YP_002410355.1 CDS yjcC NC_011750.1 4684484 4686070 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative signal transduction protein 4684484..4686070 Escherichia coli IAI39 7154267 YP_002410356.1 CDS soxS NC_011750.1 4686073 4686396 R regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS complement(4686073..4686396) Escherichia coli IAI39 7154268 YP_002410357.1 CDS soxR NC_011750.1 4686482 4686946 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91210176, 91360349, 94139656, 9564045, 10207625, 12670967, 1653416, 1708380, 7673113, 8065907, 8306957, 8631739, 8969171, 9019397, 9092651, 9204707; Product type r : regulator; DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing 4686482..4686946 Escherichia coli IAI39 7152878 YP_002410358.1 CDS yjcD NC_011750.1 4687492 4688841 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative permease 4687492..4688841 Escherichia coli IAI39 7152794 YP_002410359.1 CDS yjcE NC_011750.1 4688992 4690641 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 21557160, 11479290; Product type pt : putative transporter; putative cation/proton antiporter 4688992..4690641 Escherichia coli IAI39 7154269 YP_002410360.1 CDS actP NC_011750.1 4690723 4692372 R member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease complement(4690723..4692372) Escherichia coli IAI39 7154270 YP_002410361.1 CDS ECIAI39_4488 NC_011750.1 4692369 4692896 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4692369..4692896) Escherichia coli IAI39 7150681 YP_002410362.1 CDS ECIAI39_4489 NC_011750.1 4692929 4693459 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 4692929..4693459 Escherichia coli IAI39 7150393 YP_002410363.1 CDS ECIAI39_4490 NC_011750.1 4693564 4694286 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 4693564..4694286 Escherichia coli IAI39 7150394 YP_002410364.1 CDS acs NC_011750.1 4694345 4696303 R Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase complement(4694345..4696303) Escherichia coli IAI39 7150395 YP_002410365.1 CDS nrfA NC_011750.1 4696696 4698132 D catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 4696696..4698132 Escherichia coli IAI39 7150680 YP_002410366.1 CDS nrfB NC_011750.1 4698178 4698744 D part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 4698178..4698744 Escherichia coli IAI39 7152253 YP_002410367.1 CDS nrfC NC_011750.1 4698741 4699412 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94335626, 8057835; Product type c : carrier; formate-dependent nitrite reductase, 4Fe4S subunit 4698741..4699412 Escherichia coli IAI39 7152254 YP_002410368.1 CDS nrfD NC_011750.1 4699409 4700365 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 8057835; Product type e : enzyme; formate-dependent nitrite reductase, membrane subunit 4699409..4700365 Escherichia coli IAI39 7152255 YP_002410369.1 CDS nrfE NC_011750.1 4700445 4702103 D with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 4700445..4702103 Escherichia coli IAI39 7152256 YP_002410370.1 CDS nrfF NC_011750.1 4702096 4702479 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 9593308, 8057835, 8842153; Product type f : factor; formate-dependent nitrite reductase complex subunit NrfF 4702096..4702479 Escherichia coli IAI39 7152257 YP_002410371.1 CDS nrfG NC_011750.1 4702476 4703072 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 9593308, 8057835, 8842153; Product type f : factor; formate-dependent nitrite reductase complex subunit NrfG 4702476..4703072 Escherichia coli IAI39 7152258 YP_002410372.1 CDS gltP NC_011750.1 4703414 4704727 D carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 4703414..4704727 Escherichia coli IAI39 7152259 YP_002410373.1 CDS yjcO NC_011750.1 4704806 4705495 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4704806..4705495) Escherichia coli IAI39 7151555 YP_002410374.1 CDS fdhF NC_011750.1 4705589 4707736 R Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-H, selenopolypeptide subunit complement(4705589..4707736) Escherichia coli IAI39 7154271 YP_002410375.1 CDS yjcP NC_011750.1 4707934 4709400 R part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; putative outer membrane efflux protein MdtP complement(4707934..4709400) Escherichia coli IAI39 7151285 YP_002410376.1 CDS yjcQ NC_011750.1 4709397 4711448 R possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO complement(4709397..4711448) Escherichia coli IAI39 7154272 YP_002410377.1 CDS yjcR NC_011750.1 4711448 4712479 R with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN complement(4711448..4712479) Escherichia coli IAI39 7154273 YP_002410378.1 CDS yjcS NC_011750.1 4712982 4714967 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1587481; Product type pe : putative enzyme; putative alkyl sulfatase complement(4712982..4714967) Escherichia coli IAI39 7150396 YP_002410379.1 CDS alsK NC_011750.1 4715240 4716169 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20026827, 9401019; Product type e : enzyme; D-allose kinase complement(4715240..4716169) Escherichia coli IAI39 7154275 YP_002410380.1 CDS alsE NC_011750.1 4716153 4716848 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20026827, 9401019; Product type e : enzyme; allulose-6-phosphate 3-epimerase complement(4716153..4716848) Escherichia coli IAI39 7150723 YP_002410381.1 CDS alsC NC_011750.1 4716859 4717839 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20026827, 9401019; Product type t : transporter; D-allose transporter subunit complement(4716859..4717839) Escherichia coli IAI39 7150722 YP_002410382.1 CDS alsA NC_011750.1 4717818 4719350 R with AlsBC acts to import allose into the cell; AlsA contain 2 ATP-binding domains; D-allose transporter ATP-binding protein complement(4717818..4719350) Escherichia coli IAI39 7150721 YP_002410383.1 CDS alsB NC_011750.1 4719477 4720412 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20026827, 9401019, 10064713, 8576032; Product type t : transporter; D-allose transporter subunit complement(4719477..4720412) Escherichia coli IAI39 7150719 YP_002410384.1 CDS rpiR NC_011750.1 4720471 4721361 R involved in rpiB and als operon repression; DNA-binding transcriptional repressor RpiR complement(4720471..4721361) Escherichia coli IAI39 7150720 YP_002410385.1 CDS rpiB NC_011750.1 4721721 4722170 D catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B 4721721..4722170 Escherichia coli IAI39 7152670 YP_002410386.1 CDS yjdP NC_011750.1 4722239 4722577 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4722239..4722577 Escherichia coli IAI39 7152669 YP_002410387.1 CDS phnP NC_011750.1 4722612 4723370 R required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein complement(4722612..4723370) Escherichia coli IAI39 7154285 YP_002410388.1 CDS phnO NC_011750.1 4723372 4723806 R PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase complement(4723372..4723806) Escherichia coli IAI39 7152408 YP_002410389.1 CDS phnN NC_011750.1 4723793 4724350 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12700258, 91100346, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; ribose 1,5-bisphosphokinase complement(4723793..4724350) Escherichia coli IAI39 7152407 YP_002410390.1 CDS phnM NC_011750.1 4724350 4725486 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100346, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4724350..4725486) Escherichia coli IAI39 7152406 YP_002410391.1 CDS phnL NC_011750.1 4725483 4726163 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4725483..4726163) Escherichia coli IAI39 7152405 YP_002410392.1 CDS phnK NC_011750.1 4726342 4727100 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; phosphonate C-P lyase system protein PhnK complement(4726342..4727100) Escherichia coli IAI39 7152404 YP_002410393.1 CDS phnJ NC_011750.1 4727097 4727942 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4727097..4727942) Escherichia coli IAI39 7152403 YP_002410394.1 CDS phnI NC_011750.1 4727935 4728999 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4727935..4728999) Escherichia coli IAI39 7152402 YP_002410395.1 CDS phnH NC_011750.1 4728999 4729583 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4728999..4729583) Escherichia coli IAI39 7152401 YP_002410396.1 CDS phnG NC_011750.1 4729580 4730032 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4729580..4730032) Escherichia coli IAI39 7152400 YP_002410397.1 CDS phnF NC_011750.1 4730033 4730758 R may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF complement(4730033..4730758) Escherichia coli IAI39 7152399 YP_002410398.1 CDS phnE NC_011750.1 4730779 4731558 R Evidence 2b : Function of strongly homologous gene; Product type t : transporter; phosphonates transport system permease complement(4730779..4731558) Escherichia coli IAI39 7152398 YP_002410399.1 CDS phnD NC_011750.1 4731623 4732639 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type t : transporter; phosphonate/organophosphate ester ABC transporter periplasmic binding protein complement(4731623..4732639) Escherichia coli IAI39 7152397 YP_002410400.1 CDS phnC NC_011750.1 4732664 4733386 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type t : transporter; phosphonate/organophosphate ester ABC transporter ATP-binding protein complement(4732664..4733386) Escherichia coli IAI39 7152396 YP_002410401.1 CDS ECIAI39_4531 NC_011750.1 4734122 4734604 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9650256, 2155230; Product type pt : putative transporter; putative alkylphosphonate uptake protein in phosphonate metabolism complement(4734122..4734604) Escherichia coli IAI39 7152394 YP_002410402.1 CDS yjdA NC_011750.1 4734858 4737086 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4734858..4737086 Escherichia coli IAI39 7150397 YP_002410403.1 CDS yjcZ NC_011750.1 4737083 4737961 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4737083..4737961 Escherichia coli IAI39 7154277 YP_002410404.1 CDS proP NC_011750.1 4738225 4739727 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10049386, 12525168, 92165733, 93132799, 9871325, 99376621, 8421314; Product type t : transporter; proline/glycine betaine transporter 4738225..4739727 Escherichia coli IAI39 7154276 YP_002410405.1 CDS basS NC_011750.1 4739904 4741004 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94110256, 8282725; Product type r : regulator; sensor protein BasS/PmrB complement(4739904..4741004) Escherichia coli IAI39 7152486 YP_002410406.1 CDS basR NC_011750.1 4741005 4741673 R response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR complement(4741005..4741673) Escherichia coli IAI39 7150839 YP_002410407.1 CDS eptA NC_011750.1 4741670 4743313 R with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; putative cell division protein complement(4741670..4743313) Escherichia coli IAI39 7150838 YP_002410408.1 CDS adiC NC_011750.1 4743417 4744754 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12867448; Product type t : transporter; arginine:agmatin antiporter complement(4743417..4744754) Escherichia coli IAI39 7151236 YP_002410409.1 CDS adiY NC_011750.1 4744891 4745652 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : c; Product type r : regulator; DNA-binding transcriptional activator complement(4744891..4745652) Escherichia coli IAI39 7150690 YP_002410410.1 CDS adiA NC_011750.1 4745988 4748258 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93186686, 2830169, 4204273, 8383109; Product type e : enzyme; biodegradative arginine decarboxylase complement(4745988..4748258) Escherichia coli IAI39 7150691 YP_002410411.1 CDS melR NC_011750.1 4748454 4749362 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90060832, 9108148, 1445207, 2684786, 2830169; Product type r : regulator; DNA-binding transcriptional regulator MelR complement(4748454..4749362) Escherichia coli IAI39 7150689 YP_002410412.1 CDS melA NC_011750.1 4749645 4751000 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87174747, 88162811, 90248411, 2831880, 3031590, 6329200; Product type e : enzyme; alpha-galactosidase, NAD(P)-binding 4749645..4751000 Escherichia coli IAI39 7152042 YP_002410413.1 CDS melB NC_011750.1 4751115 4752524 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14757226, 90241878, 92297631, 93155159, 1730719, 1872836, 6323466, 8672452; Product type t : transporter; melibiose:sodium symporter 4751115..4752524 Escherichia coli IAI39 7152040 YP_002410414.1 CDS yjdF NC_011750.1 4752663 4753292 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4752663..4753292) Escherichia coli IAI39 7152041 YP_002410415.1 CDS fumB NC_011750.1 4753415 4755061 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86142617, 88193096, 89255123, 2656658; Product type e : enzyme; anaerobic class I fumarate hydratase complement(4753415..4755061) Escherichia coli IAI39 7154279 YP_002410416.1 CDS dcuB NC_011750.1 4755139 4756479 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter complement(4755139..4756479) Escherichia coli IAI39 7151454 YP_002410417.1 CDS dcuR NC_011750.1 4757050 4757769 R response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR complement(4757050..4757769) Escherichia coli IAI39 7151096 YP_002410418.1 CDS dcuS NC_011750.1 4757766 4759397 R C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS complement(4757766..4759397) Escherichia coli IAI39 7151099 YP_002410419.1 CDS yjdI NC_011750.1 4759578 4759808 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4759578..4759808 Escherichia coli IAI39 7151100 YP_002410420.1 CDS yjdJ NC_011750.1 4759820 4760092 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA N-acyltransferase domain-containing acyltransferase 4759820..4760092 Escherichia coli IAI39 7154280 YP_002410421.1 CDS yjdK NC_011750.1 4760321 4760617 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4760321..4760617 Escherichia coli IAI39 7154281 YP_002410422.1 CDS yjdO NC_011750.1 4760645 4760818 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4760645..4760818 Escherichia coli IAI39 7154282 YP_002410423.1 CDS lysU NC_011750.1 4760937 4762454 R class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(4760937..4762454) Escherichia coli IAI39 7154284 YP_002410424.1 CDS yjdL NC_011750.1 4762691 4764061 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter complement(4762691..4764061) Escherichia coli IAI39 7151987 YP_002410425.1 CDS cadA NC_011750.1 4764202 4766349 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92105022, 92210511, 1370290, 1556085, 4204273; Product type e : enzyme; lysine decarboxylase 1 complement(4764202..4766349) Escherichia coli IAI39 7154283 YP_002410426.1 CDS cadB NC_011750.1 4766429 4767763 R antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein; lysine/cadaverine antiporter complement(4766429..4767763) Escherichia coli IAI39 7150891 YP_002410427.1 CDS cadC NC_011750.1 4768129 4769667 R regulates the cadBA operon; DNA-binding transcriptional activator CadC complement(4768129..4769667) Escherichia coli IAI39 7150892 YP_002410428.1 CDS ECIAI39_4563 NC_011750.1 4770471 4771319 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4770471..4771319) Escherichia coli IAI39 7150893 YP_002410429.1 CDS ECIAI39_4564 NC_011750.1 4771394 4771720 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 4771394..4771720 Escherichia coli IAI39 7150398 YP_002410430.1 CDS ECIAI39_4565 NC_011750.1 4771720 4772607 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 4771720..4772607 Escherichia coli IAI39 7150399 YP_002410431.1 CDS ECIAI39_4566 NC_011750.1 4772610 4772873 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(4772610..4772873) Escherichia coli IAI39 7150400 YP_002410432.1 CDS ECIAI39_4567 NC_011750.1 4772944 4773789 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9987116; hypothetical protein complement(4772944..4773789) Escherichia coli IAI39 7150401 YP_002410433.1 CDS ECIAI39_4568 NC_011750.1 4773874 4774122 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4773874..4774122) Escherichia coli IAI39 7150402 YP_002410434.1 CDS yeeW NC_011750.1 4774089 4774577 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4774089..4774577) Escherichia coli IAI39 7150403 YP_002410435.1 CDS yeeV NC_011750.1 4774574 4774951 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; toxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage complement(4774574..4774951) Escherichia coli IAI39 7153729 YP_002410436.1 CDS yeeT NC_011750.1 4775486 4775707 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(4775486..4775707) Escherichia coli IAI39 7153723 YP_002410437.1 CDS yeeS NC_011750.1 4775770 4776216 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : putative factor; putative DNA repair protein; CP4-44 prophage complement(4775770..4776216) Escherichia coli IAI39 7153720 YP_002410438.1 CDS ECIAI39_4574 NC_011750.1 4776261 4776746 R Evidence 4 : Homologs of previously reported genes of unknown function; putative antirestriction protein complement(4776261..4776746) Escherichia coli IAI39 7153717 YP_002410439.1 CDS ECIAI39_4575 NC_011750.1 4776837 4777655 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4776837..4777655) Escherichia coli IAI39 7150404 YP_002410440.1 CDS ECIAI39_4576 NC_011750.1 4777745 4777978 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4777745..4777978) Escherichia coli IAI39 7150405 YP_002410441.1 CDS ECIAI39_4577 NC_011750.1 4777984 4778766 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4777984..4778766) Escherichia coli IAI39 7150406 YP_002410442.1 CDS ECIAI39_4578 NC_011750.1 4779518 4779673 R hypothetical protein complement(4779518..4779673) Escherichia coli IAI39 7150407 YP_002410443.1 CDS ECIAI39_4579 NC_011750.1 4779692 4780576 R Evidence 4 : Homologs of previously reported genes of unknown function; putative GTPase complement(4779692..4780576) Escherichia coli IAI39 7150408 YP_002410444.1 CDS ECIAI39_4580 NC_011750.1 4780677 4781900 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4780677..4781900 Escherichia coli IAI39 7150409 YP_002410445.1 CDS ECIAI39_4581 NC_011750.1 4782894 4783220 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 4782894..4783220 Escherichia coli IAI39 7150410 YP_002410446.1 CDS ECIAI39_4582 NC_011750.1 4783217 4784107 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 4783217..4784107 Escherichia coli IAI39 7150411 YP_002410447.1 CDS ECIAI39_4583 NC_011750.1 4784164 4784337 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4784164..4784337 Escherichia coli IAI39 7150412 YP_002410448.1 CDS papI NC_011750.1 4784680 4784913 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2868893, 1357526; Product type r : regulator; pap operon regulatory protein PapI complement(4784680..4784913) Escherichia coli IAI39 7150413 YP_002410449.1 CDS ECIAI39_4585 NC_011750.1 4785188 4785358 D hypothetical protein 4785188..4785358 Escherichia coli IAI39 7152344 YP_002410450.1 CDS papB NC_011750.1 4785345 4785659 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2656260, 2868893; Product type r : regulator; pap operon regulatory protein PapB 4785345..4785659 Escherichia coli IAI39 7150414 YP_002410451.1 CDS papA NC_011750.1 4785833 4786429 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6140260, 1357526, 10049807; Product type s : structure; major pilin protein PapA 4785833..4786429 Escherichia coli IAI39 7152332 YP_002410452.1 CDS papH NC_011750.1 4786493 4787080 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2882856, 1357526, 2897064; Product type s : structure; minor pilin protein PapH 4786493..4787080 Escherichia coli IAI39 7152330 YP_002410453.1 CDS papC NC_011750.1 4787118 4789649 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2897064, 1357526, 12399496, 2572580, 7909802, 9501230; Product type f : factor; outer membrane usher protein PapC 4787118..4789649 Escherichia coli IAI39 7152342 YP_002410454.1 CDS papD NC_011750.1 4789720 4790454 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1357526, 10049807, 2478891, 10446050; Product type f : factor; Chaperone protein PapD 4789720..4790454 Escherichia coli IAI39 7152333 YP_002410455.1 CDS papJ NC_011750.1 4790491 4791072 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1975085, 1357526; Product type f : factor; P pilus assembly protein PapJ 4790491..4791072 Escherichia coli IAI39 7152334 YP_002410456.1 CDS papK NC_011750.1 4791079 4791618 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1357526, 8096174, 10049807, 10446050; Product type s : structure; fimbrial adapter PapK 4791079..4791618 Escherichia coli IAI39 7152345 YP_002410457.1 CDS papE NC_011750.1 4791627 4792166 D Evidence 2b : Function of strongly homologous gene; PubMedId : 2869489, 2895103, 1357526, 10049807; Product type s : structure; fimbrial tip protein PapE 4791627..4792166 Escherichia coli IAI39 7152346 YP_002410458.1 CDS papF NC_011750.1 4792241 4792741 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2869489, 2895103, 1357526, 8096174, 10049807; Product type s : structure; fimbrial adapter PapF 4792241..4792741 Escherichia coli IAI39 7152336 YP_002410459.1 CDS papG NC_011750.1 4792785 4793795 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1357526, 2895103, 11440716; Product type s : structure; fimbrial PapG protein 4792785..4793795 Escherichia coli IAI39 7152338 YP_002410460.1 CDS tia NC_011750.1 4794146 4794901 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8675335, 16369033; Product type f : factor; Tia invasion determinant 4794146..4794901 Escherichia coli IAI39 7152341 YP_002410461.1 CDS ECIAI39_4597 NC_011750.1 4795076 4796575 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative membrane-associated, metal-dependent hydrolase 4795076..4796575 Escherichia coli IAI39 7152984 YP_002410462.1 CDS ECIAI39_4598 NC_011750.1 4796684 4800211 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative superfamily I DNA helicase complement(4796684..4800211) Escherichia coli IAI39 7150415 YP_002410463.1 CDS int NC_011750.1 4800651 4801913 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Prophage integrase complement(4800651..4801913) Escherichia coli IAI39 7150416 YP_002410464.1 CDS yjdC NC_011750.1 4802293 4802868 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1370290; Product type pr : putative regulator; putative transcriptional regulator complement(4802293..4802868) Escherichia coli IAI39 7150588 YP_002410465.1 CDS dipZ NC_011750.1 4802905 4804602 R two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein complement(4802905..4804602) Escherichia coli IAI39 7154278 YP_002410466.1 CDS cutA NC_011750.1 4804578 4804916 R copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA complement(4804578..4804916) Escherichia coli IAI39 7151143 YP_002410467.1 CDS dcuA NC_011750.1 4805032 4806333 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter complement(4805032..4806333) Escherichia coli IAI39 7151034 YP_002410468.1 CDS aspA NC_011750.1 4806451 4807887 R catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase complement(4806451..4807887) Escherichia coli IAI39 7151095 YP_002410469.1 CDS fxsA NC_011750.1 4808224 4808700 D F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 4808224..4808700 Escherichia coli IAI39 7150806 YP_002410470.1 CDS yjeH NC_011750.1 4808716 4809972 R uncharacterized member of the APC superfamily of amino acid transporters; unknown function; inner membrane protein YjeH complement(4808716..4809972) Escherichia coli IAI39 7151458 YP_002410471.1 CDS groES NC_011750.1 4810248 4810541 D 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 4810248..4810541 Escherichia coli IAI39 7154288 YP_002410472.1 CDS groEL NC_011750.1 4810585 4812231 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 4810585..4812231 Escherichia coli IAI39 7151586 YP_002410473.1 CDS yjeI NC_011750.1 4812366 4812719 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4812366..4812719 Escherichia coli IAI39 7151585 YP_002410474.1 CDS yjeJ NC_011750.1 4812769 4813638 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4812769..4813638) Escherichia coli IAI39 7154289 YP_002410475.1 CDS yjeK NC_011750.1 4813873 4814901 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019591, 10629195; Product type pe : putative enzyme; putative lysine aminomutase complement(4813873..4814901) Escherichia coli IAI39 7154290 YP_002410476.1 CDS efp NC_011750.1 4814943 4815509 D Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 4814943..4815509 Escherichia coli IAI39 7154291 YP_002410477.1 CDS insB NC_011750.1 4815759 4816262 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' complement(4815759..4816262) Escherichia coli IAI39 7151207 YP_002410478.1 CDS insA NC_011750.1 4816181 4816456 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA complement(4816181..4816456) Escherichia coli IAI39 7151800 YP_002410479.1 CDS sugE NC_011750.1 4816895 4817212 D member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations; quaternary ammonium compound-resistance protein SugE 4816895..4817212 Escherichia coli IAI39 7151789 YP_002410480.1 CDS blc NC_011750.1 4817209 4817742 R lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc complement(4817209..4817742) Escherichia coli IAI39 7152929 YP_002410481.1 CDS ampC NC_011750.1 4817830 4818963 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92212899, 97464439, 99421326, 10595535, 6795623, 7041115, 9819201; Product type e : enzyme; beta-lactamase complement(4817830..4818963) Escherichia coli IAI39 7150871 YP_002410482.1 CDS frdD NC_011750.1 4819026 4819385 R in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D complement(4819026..4819385) Escherichia coli IAI39 7150729 YP_002410483.1 CDS frdC NC_011750.1 4819396 4819791 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C complement(4819396..4819791) Escherichia coli IAI39 7151411 YP_002410484.1 CDS frdB NC_011750.1 4819802 4820536 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit complement(4819802..4820536) Escherichia coli IAI39 7151410 YP_002410485.1 CDS frdA NC_011750.1 4820529 4822337 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit complement(4820529..4822337) Escherichia coli IAI39 7151409 YP_002410486.1 CDS poxA NC_011750.1 4822662 4823639 D lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 4822662..4823639 Escherichia coli IAI39 7151408 YP_002410487.1 CDS yjeM NC_011750.1 4823858 4825360 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative transporter 4823858..4825360 Escherichia coli IAI39 7152450 YP_002410488.1 CDS yjeP NC_011750.1 4825511 4828834 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; hypothetical protein complement(4825511..4828834) Escherichia coli IAI39 7154292 YP_002410489.1 CDS psd NC_011750.1 4828856 4829824 R catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase complement(4828856..4829824) Escherichia coli IAI39 7154293 YP_002410490.1 CDS rsgA NC_011750.1 4829921 4830973 R EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase complement(4829921..4830973) Escherichia coli IAI39 7152500 YP_002410491.1 CDS orn NC_011750.1 4831068 4831613 D 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4831068..4831613 Escherichia coli IAI39 7152742 YP_002410492.1 CDS yjeS NC_011750.1 4832392 4833531 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier; putative Fe-S electron transport protein complement(4832392..4833531) Escherichia coli IAI39 7150582 YP_002410493.1 CDS yjeF NC_011750.1 4833530 4835077 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein 4833530..4835077 Escherichia coli IAI39 7154294 YP_002410494.1 CDS yjeE NC_011750.1 4835049 4835510 D possibly involved in cell wall synthesis; putative ATPase 4835049..4835510 Escherichia coli IAI39 7154287 YP_002410495.1 CDS amiB NC_011750.1 4835529 4836866 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21348478, 87242501, 1594459, 7511774; Product type e : enzyme; N-acetylmuramoyl-l-alanine amidase II 4835529..4836866 Escherichia coli IAI39 7154286 YP_002410496.1 CDS mutL NC_011750.1 4836873 4838723 D This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 4836873..4838723 Escherichia coli IAI39 7150726 YP_002410497.1 CDS miaA NC_011750.1 4838716 4839666 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 4838716..4839666 Escherichia coli IAI39 7152156 YP_002410498.1 CDS hfq NC_011750.1 4839753 4840061 D Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 4839753..4840061 Escherichia coli IAI39 7152078 YP_002410499.1 CDS hflX NC_011750.1 4840138 4841418 D involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; putative GTPase HflX 4840138..4841418 Escherichia coli IAI39 7151641 YP_002410500.1 CDS hflK NC_011750.1 4841504 4842763 D with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 4841504..4842763 Escherichia coli IAI39 7151640 YP_002410501.1 CDS hflC NC_011750.1 4842766 4843770 D with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 4842766..4843770 Escherichia coli IAI39 7151639 YP_002410502.1 CDS yjeT NC_011750.1 4843852 4844049 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4843852..4844049 Escherichia coli IAI39 7151637 YP_002410503.1 CDS purA NC_011750.1 4844153 4845451 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 4844153..4845451 Escherichia coli IAI39 7154295 YP_002410504.1 CDS nsrR NC_011750.1 4845656 4846081 D negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 4845656..4846081 Escherichia coli IAI39 7152523 YP_002410505.1 CDS rnr NC_011750.1 4846120 4848561 D 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 4846120..4848561 Escherichia coli IAI39 7152260 YP_002410506.1 CDS rlmB NC_011750.1 4848742 4849473 D Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 4848742..4849473 Escherichia coli IAI39 7152662 YP_002410507.1 CDS yjfI NC_011750.1 4849600 4850001 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4849600..4850001 Escherichia coli IAI39 7152638 YP_002410508.1 CDS yjfJ NC_011750.1 4850020 4850718 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator effector protein 4850020..4850718 Escherichia coli IAI39 7154299 YP_002410509.1 CDS yjfK NC_011750.1 4850768 4851427 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4850768..4851427 Escherichia coli IAI39 7154300 YP_002410510.1 CDS yjfL NC_011750.1 4851445 4851843 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4851445..4851843 Escherichia coli IAI39 7154301 YP_002410511.1 CDS yjfM NC_011750.1 4851853 4852491 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4851853..4852491 Escherichia coli IAI39 7154302 YP_002410512.1 CDS yjfC NC_011750.1 4852494 4853657 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative synthetase/amidase 4852494..4853657 Escherichia coli IAI39 7154303 YP_002410513.1 CDS aidB NC_011750.1 4853741 4855366 D catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 4853741..4855366 Escherichia coli IAI39 7154296 YP_002410514.1 CDS yjfN NC_011750.1 4855483 4855758 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4855483..4855758) Escherichia coli IAI39 7150708 YP_002410515.1 CDS yjfO NC_011750.1 4855907 4856236 R in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility; putative biofilm stress and motility protein A complement(4855907..4856236) Escherichia coli IAI39 7154304 YP_002410516.1 CDS yjfP NC_011750.1 4856418 4857167 D YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 4856418..4857167 Escherichia coli IAI39 7154305 YP_002410517.1 CDS ulaR NC_011750.1 4857164 4857919 R negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR complement(4857164..4857919) Escherichia coli IAI39 7154306 YP_002410518.1 CDS ulaG NC_011750.1 4858027 4859091 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12644495, 15808744; Product type pe : putative enzyme; putative L-ascorbate 6-phosphate lactonase complement(4858027..4859091) Escherichia coli IAI39 7153101 YP_002410519.1 CDS ulaA NC_011750.1 4859389 4860843 D membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 4859389..4860843 Escherichia coli IAI39 7153100 YP_002410520.1 CDS ulaB NC_011750.1 4860859 4861164 D involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIB 4860859..4861164 Escherichia coli IAI39 7153094 YP_002410521.1 CDS ulaC NC_011750.1 4861174 4861638 D involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIA 4861174..4861638 Escherichia coli IAI39 7153095 YP_002410522.1 CDS ulaD NC_011750.1 4861652 4862302 D catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 4861652..4862302 Escherichia coli IAI39 7153096 YP_002410523.1 CDS ulaE NC_011750.1 4862312 4863166 D UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 4862312..4863166 Escherichia coli IAI39 7153097 YP_002410524.1 CDS sgaE NC_011750.1 4863166 4863852 D catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4863166..4863852 Escherichia coli IAI39 7153098 YP_002410525.1 CDS yjfY NC_011750.1 4863981 4864256 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4863981..4864256) Escherichia coli IAI39 7153099 YP_002410526.1 CDS rpsF NC_011750.1 4864583 4864978 D binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 4864583..4864978 Escherichia coli IAI39 7154307 YP_002410527.1 CDS rpsR NC_011750.1 4865304 4865531 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4865304..4865531 Escherichia coli IAI39 7152718 YP_002410528.1 CDS rplI NC_011750.1 4865573 4866022 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4865573..4866022 Escherichia coli IAI39 7152730 YP_002410529.1 CDS yjfZ NC_011750.1 4866093 4866887 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4866093..4866887) Escherichia coli IAI39 7152677 YP_002410530.1 CDS ECIAI39_4669 NC_011750.1 4867157 4868434 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Hexuronate transporter complement(4867157..4868434) Escherichia coli IAI39 7154308 YP_002410531.1 CDS ECIAI39_4670 NC_011750.1 4868527 4870599 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase complement(4868527..4870599) Escherichia coli IAI39 7150417 YP_002410532.1 CDS ECIAI39_4671 NC_011750.1 4870596 4872137 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative CoA transferase complement(4870596..4872137) Escherichia coli IAI39 7150418 YP_002410533.1 CDS ECIAI39_4672 NC_011750.1 4872147 4872923 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acyl-CoA hydratase complement(4872147..4872923) Escherichia coli IAI39 7150419 YP_002410534.1 CDS ECIAI39_4673 NC_011750.1 4872933 4873775 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; hypothetical protein complement(4872933..4873775) Escherichia coli IAI39 7150420 YP_002410535.1 CDS ECIAI39_4674 NC_011750.1 4873785 4874576 R catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase complement(4873785..4874576) Escherichia coli IAI39 7150421 YP_002410536.1 CDS ytfA NC_011750.1 4874717 4875436 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative transcriptional regulator 4874717..4875436 Escherichia coli IAI39 7150422 YP_002410537.1 CDS ytfB NC_011750.1 4875420 4876058 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8559074; Product type ps : putative structure; putative cell envelope opacity-associated protein complement(4875420..4876058) Escherichia coli IAI39 7154569 YP_002410538.1 CDS fklB NC_011750.1 4876276 4876896 D FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 4876276..4876896 Escherichia coli IAI39 7154570 YP_002410539.1 CDS cycA NC_011750.1 4877205 4878608 D involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 4877205..4878608 Escherichia coli IAI39 7151344 YP_002410540.1 CDS ECIAI39_4679 NC_011750.1 4878742 4879899 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4878742..4879899 Escherichia coli IAI39 7151041 YP_002410541.1 CDS ECIAI39_4680 NC_011750.1 4879932 4881425 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4879932..4881425 Escherichia coli IAI39 7150423 YP_002410542.1 CDS ytfE NC_011750.1 4881470 4882132 R Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein complement(4881470..4882132) Escherichia coli IAI39 7150424 YP_002410543.1 CDS ytfF NC_011750.1 4882240 4883214 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4882240..4883214) Escherichia coli IAI39 7154571 YP_002410544.1 CDS ytfG NC_011750.1 4883313 4884173 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14747727; Product type e : enzyme; NAD(P)H:quinone oxidoreductase complement(4883313..4884173) Escherichia coli IAI39 7154572 YP_002410545.1 CDS ytfH NC_011750.1 4884262 4884642 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20088838; Product type pr : putative regulator; putative transcriptional regulator 4884262..4884642 Escherichia coli IAI39 7154573 YP_002410546.1 CDS cpdB NC_011750.1 4884771 4886714 R periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein complement(4884771..4886714) Escherichia coli IAI39 7154574 YP_002410547.1 CDS cysQ NC_011750.1 4886904 4887644 D catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 4886904..4887644 Escherichia coli IAI39 7150985 YP_002410548.1 CDS ytfJ NC_011750.1 4887634 4888191 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pr : putative regulator; putative transcriptional regulator complement(4887634..4888191) Escherichia coli IAI39 7151068 YP_002410549.1 CDS ytfK NC_011750.1 4888516 4888722 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4888516..4888722 Escherichia coli IAI39 7154575 YP_002410550.1 CDS ytfL NC_011750.1 4888783 4890126 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(4888783..4890126) Escherichia coli IAI39 7154576 YP_002410551.1 CDS msrA NC_011750.1 4890449 4891087 R this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A complement(4890449..4891087) Escherichia coli IAI39 7154577 YP_002410552.1 CDS ytfM NC_011750.1 4891293 4893026 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4891293..4893026 Escherichia coli IAI39 7152134 YP_002410553.1 CDS ytfN NC_011750.1 4893023 4896802 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4893023..4896802 Escherichia coli IAI39 7154578 YP_002410554.1 CDS ytfP NC_011750.1 4896805 4897146 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4896805..4897146 Escherichia coli IAI39 7154579 YP_002410555.1 CDS chpS NC_011750.1 4897358 4897609 D part of the toxin-antitoxin ChpB-ChpS system; antitoxin ChpS 4897358..4897609 Escherichia coli IAI39 7154580 YP_002410556.1 CDS chpB NC_011750.1 4897603 4897953 D toxin of the ChpB-ChpS toxin-antitoxin system; toxin ChpB 4897603..4897953 Escherichia coli IAI39 7150943 YP_002410557.1 CDS ppa NC_011750.1 4898032 4898562 R catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase complement(4898032..4898562) Escherichia coli IAI39 7150941 YP_002410558.1 CDS ytfQ NC_011750.1 4898872 4899828 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pt : putative transporter; putative sugar ABC transporter periplasmic-binding protein 4898872..4899828 Escherichia coli IAI39 7152452 YP_002410559.1 CDS ytfR NC_011750.1 4899968 4901470 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter ATP-binding protein 4899968..4901470 Escherichia coli IAI39 7154581 YP_002410560.1 CDS ytfT NC_011750.1 4901484 4902506 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sugar ABC transporter membrane protein 4901484..4902506 Escherichia coli IAI39 7154582 YP_002410561.1 CDS insG NC_011750.1 4902928 4904274 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase, IS4 4902928..4904274 Escherichia coli IAI39 7154297 YP_002410562.1 CDS fbp NC_011750.1 4904960 4905958 R catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase complement(4904960..4905958) Escherichia coli IAI39 7154298 YP_002410563.1 CDS mpl NC_011750.1 4906134 4907507 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96404780, 2843822, 7984428, 8808921; Product type e : enzyme; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 4906134..4907507 Escherichia coli IAI39 7151281 YP_002410564.1 CDS ECIAI39_4706 NC_011750.1 4907588 4908310 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group complement(4907588..4908310) Escherichia coli IAI39 7152114 YP_002410565.1 CDS ECIAI39_4707 NC_011750.1 4908415 4908945 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 complement(4908415..4908945) Escherichia coli IAI39 7150425 YP_002410566.1 CDS yjgA NC_011750.1 4909099 4909650 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4909099..4909650) Escherichia coli IAI39 7150426 YP_002410567.1 CDS pmbA NC_011750.1 4909744 4911096 D protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 4909744..4911096 Escherichia coli IAI39 7154309 YP_002410568.1 CDS cybC NC_011750.1 4911280 4911666 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1761034, 8499452, 10393541; Product type c : carrier; soluble cytochrome b562 4911280..4911666 Escherichia coli IAI39 7152431 YP_002410569.1 CDS ECIAI39_4711 NC_011750.1 4911857 4912096 D Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor; bifunctional antitoxin/transcriptional repressor RelB 4911857..4912096 Escherichia coli IAI39 7151040 YP_002410570.1 CDS nrdG NC_011750.1 4912097 4912561 R activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein complement(4912097..4912561) Escherichia coli IAI39 7150427 YP_002410571.1 CDS nrdD NC_011750.1 4912751 4914889 R Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase complement(4912751..4914889) Escherichia coli IAI39 7152249 YP_002410572.1 CDS treC NC_011750.1 4915283 4916938 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264345, 93302496, 8083158, 8421692; Product type e : enzyme; trehalose-6-phosphate hydrolase complement(4915283..4916938) Escherichia coli IAI39 7152246 YP_002410573.1 CDS treB NC_011750.1 4916988 4918409 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system trehalose(maltose)-specific transporter subunits IIBC complement(4916988..4918409) Escherichia coli IAI39 7153019 YP_002410574.1 CDS treR NC_011750.1 4918528 4919475 R regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor complement(4918528..4919475) Escherichia coli IAI39 7153018 YP_002410575.1 CDS mgtA NC_011750.1 4919854 4922550 D P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 4919854..4922550 Escherichia coli IAI39 7153021 YP_002410576.1 CDS yjgF NC_011750.1 4922756 4923142 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12515541, 10493123, 10595546, 9298646; Product type pe : putative enzyme; ketoacid-binding protein complement(4922756..4923142) Escherichia coli IAI39 7152069 YP_002410577.1 CDS pyrI NC_011750.1 4923215 4923676 R involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase regulatory subunit complement(4923215..4923676) Escherichia coli IAI39 7154312 YP_002410578.1 CDS pyrB NC_011750.1 4923689 4924624 R catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit complement(4923689..4924624) Escherichia coli IAI39 7152555 YP_002410579.1 CDS pyrL NC_011750.1 4924628 4924762 R Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; pyrBI operon leader peptide complement(4924628..4924762) Escherichia coli IAI39 7152548 YP_002410580.1 CDS ECIAI39_4721 NC_011750.1 4924852 4925406 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative arginine repressor complement(4924852..4925406) Escherichia coli IAI39 7152556 YP_002410581.1 CDS ECIAI39_4722 NC_011750.1 4925456 4926904 R Evidence 4 : Homologs of previously reported genes of unknown function; putative C4-dicarboxylate transport membrane protein complement(4925456..4926904) Escherichia coli IAI39 7150428 YP_002410582.1 CDS arcB NC_011750.1 4926916 4927947 R catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase complement(4926916..4927947) Escherichia coli IAI39 7150429 YP_002410583.1 CDS arcC NC_011750.1 4927944 4928900 R reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase complement(4927944..4928900) Escherichia coli IAI39 7150758 YP_002410584.1 CDS ECIAI39_4725 NC_011750.1 4928887 4930110 R catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase complement(4928887..4930110) Escherichia coli IAI39 7150759 YP_002410585.1 CDS yjgK NC_011750.1 4930785 4931237 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11115104; hypothetical protein 4930785..4931237 Escherichia coli IAI39 7150430 YP_002410586.1 CDS argI NC_011750.1 4931282 4932286 R catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase; when both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III; ornithine carbamoyltransferase subunit F complement(4931282..4932286) Escherichia coli IAI39 7154313 YP_002410587.1 CDS yjgD NC_011750.1 4932448 4932864 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4932448..4932864 Escherichia coli IAI39 7150767 YP_002410588.1 CDS yjgM NC_011750.1 4933041 4933544 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative acetyltransferase complement(4933041..4933544) Escherichia coli IAI39 7154311 YP_002410589.1 CDS yjgN NC_011750.1 4933737 4934924 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type m : membrane component; hypothetical protein 4933737..4934924 Escherichia coli IAI39 7154314 YP_002410590.1 CDS valS NC_011750.1 4934971 4937826 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(4934971..4937826) Escherichia coli IAI39 7154315 YP_002410591.1 CDS holC NC_011750.1 4937826 4938269 R binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi complement(4937826..4938269) Escherichia coli IAI39 7153126 YP_002410592.1 CDS pepA NC_011750.1 4938623 4940134 R catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase complement(4938623..4940134) Escherichia coli IAI39 7151669 YP_002410593.1 CDS yjgP NC_011750.1 4940401 4941501 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4940401..4941501 Escherichia coli IAI39 7152361 YP_002410594.1 CDS yjgQ NC_011750.1 4941501 4942583 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein 4941501..4942583 Escherichia coli IAI39 7154316 YP_002410595.1 CDS yjgR NC_011750.1 4942702 4944204 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative ATPase complement(4942702..4944204) Escherichia coli IAI39 7154317 YP_002410596.1 CDS idnR NC_011750.1 4944282 4945280 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9119199, 98324983, 9658018; Product type r : regulator; DNA-binding transcriptional repressor, 5-gluconate-binding complement(4944282..4945280) Escherichia coli IAI39 7154318 YP_002410597.1 CDS idnT NC_011750.1 4945347 4946666 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 9119199, 93139975, 98324983, 9658018; Product type t : transporter; L-idonate and D-gluconate transporter complement(4945347..4946666) Escherichia coli IAI39 7151757 YP_002410598.1 CDS idnO NC_011750.1 4946731 4947495 R Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase complement(4946731..4947495) Escherichia coli IAI39 7151758 YP_002410599.1 CDS idnD NC_011750.1 4947519 4948550 R NAD-binding; L-idonate 5-dehydrogenase complement(4947519..4948550) Escherichia coli IAI39 7151756 YP_002410600.1 CDS idnK NC_011750.1 4948767 4949330 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87310381, 93139975, 98324983, 9658018, 14832279; Product type e : enzyme; D-gluconate kinase 4948767..4949330 Escherichia coli IAI39 7151754 YP_002410601.1 CDS yjgB NC_011750.1 4949334 4950353 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12147722; Product type pe : putative enzyme; putative alcohol dehydrogenase, Zn-dependent and NAD(P)-binding complement(4949334..4950353) Escherichia coli IAI39 7151755 YP_002410602.1 CDS intB NC_011750.1 4950895 4952085 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative integrase; KpLE2 phage-like element 4950895..4952085 Escherichia coli IAI39 7150583 YP_002410604.1 CDS ECIAI39_4746 NC_011750.1 4954084 4954227 D Evidence 6 : Doubtful CDS; hypothetical protein 4954084..4954227 Escherichia coli IAI39 7150432 YP_002410605.1 CDS yjhB NC_011750.1 4954772 4955989 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative sialic acid transporter 4954772..4955989 Escherichia coli IAI39 7150433 YP_002410606.1 CDS yjhC NC_011750.1 4956001 4957119 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative oxidoreductase 4956001..4957119 Escherichia coli IAI39 7154320 YP_002410607.1 CDS yjhD NC_011750.1 4957340 4957570 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4957340..4957570) Escherichia coli IAI39 7154321 YP_002410608.1 CDS ECIAI39_4750 NC_011750.1 4957575 4957823 D hypothetical protein 4957575..4957823 Escherichia coli IAI39 7154322 YP_002410609.1 CDS ECIAI39_4751 NC_011750.1 4957911 4958087 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF A (fragment), IS911 4957911..4958087 Escherichia coli IAI39 7150434 YP_002410610.1 CDS ECIAI39_4752 NC_011750.1 4958373 4959134 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase (fragment), IS110 family 4958373..4959134 Escherichia coli IAI39 7150435 YP_002410611.1 CDS ECIAI39_4753 NC_011750.1 4959261 4960151 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 complement(4959261..4960151) Escherichia coli IAI39 7150436 YP_002410612.1 CDS ECIAI39_4754 NC_011750.1 4960148 4960474 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 complement(4960148..4960474) Escherichia coli IAI39 7150437 YP_002410613.1 CDS betU NC_011750.1 4960500 4961786 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702297; Product type t : transporter; betaine-carnitine-choline transporter family member complement(4960500..4961786) Escherichia coli IAI39 7150438 YP_002410614.1 CDS ECIAI39_4756 NC_011750.1 4961934 4962752 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS600 complement(4961934..4962752) Escherichia coli IAI39 7150856 YP_002410615.1 CDS msbB NC_011750.1 4963268 4964212 R Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase complement(4963268..4964212) Escherichia coli IAI39 7151826 YP_002410616.1 CDS virK NC_011750.1 4964277 4965227 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1406277; Product type r : regulator; regulator of virG protein complement(4964277..4965227) Escherichia coli IAI39 7152131 YP_002410617.1 CDS ECIAI39_4760 NC_011750.1 4965232 4966320 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Glycosyl transferase complement(4965232..4966320) Escherichia coli IAI39 7153129 YP_002410618.1 CDS shf NC_011750.1 4966323 4967144 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative polysaccharide deacetylase complement(4966323..4967144) Escherichia coli IAI39 7150440 YP_002410619.1 CDS ECIAI39_4762 NC_011750.1 4967309 4967653 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS911 4967309..4967653 Escherichia coli IAI39 7152849 YP_002410620.1 CDS insO NC_011750.1 4967709 4968308 D Evidence 7 : Gene remnant; Product type pe : putative enzyme; transposase ORF B (fragment), IS911 4967709..4968308 Escherichia coli IAI39 7150441 YP_002410621.1 CDS yjhV NC_011750.1 4968474 4968887 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4968474..4968887 Escherichia coli IAI39 7151827 YP_002410622.1 CDS fecE NC_011750.1 4969445 4970212 R Part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate transporter ATP-binding subunit complement(4969445..4970212) Escherichia coli IAI39 7154325 YP_002410623.1 CDS fecD NC_011750.1 4970213 4971199 R Ferric citrate binds FecA and is transported across the outer membrane while transmits a signal across the cytoplasmic membrane protein FecR. FecR transmits a signal across the membrane and activates the cytoplasmic FecI that directs the RNA polymerase to express the fecABCDE operon (which encodes the ferric citrate outer membrane receptor and the ferric citrate ABC transporter), as well as fecIR. FecD is one of two (along with FecC) integral membrane protein components of the iron dicitrate ABC transporter.; iron-dicitrate transporter subunit FecD complement(4970213..4971199) Escherichia coli IAI39 7151298 YP_002410624.1 CDS fecC NC_011750.1 4971166 4972164 R part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate transporter permease subunit complement(4971166..4972164) Escherichia coli IAI39 7151297 YP_002410625.1 CDS fecB NC_011750.1 4972161 4973063 R part of the ABC transporter involved in the uptake of citrate-dependent Fe(3+); iron-dicitrate transporter substrate-binding subunit complement(4972161..4973063) Escherichia coli IAI39 7151296 YP_002410626.1 CDS fecA NC_011750.1 4973108 4975432 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90105402, 91072220, 92269759, 2836368; Product type t : transporter; ferric citrate outer membrane transporter; KpLE2 phage-like element complement(4973108..4975432) Escherichia coli IAI39 7151295 YP_002410627.1 CDS fecR NC_011750.1 4975519 4976472 R with FecA forms the FecAR signal transduction system; ferric citrate binds FecA and transmits a signal across the outer membrane to FecR. FecR transmits a signal across the cytoplasmic membrane and activates the sigma 70 protein FecI that directs the RNA polymerase to express the fecABCDE operon; fec operon regulator FecR complement(4975519..4976472) Escherichia coli IAI39 7151294 YP_002410628.1 CDS fecI NC_011750.1 4976469 4976990 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor regulates the genes for iron dicitrate transport; RNA polymerase sigma factor FecI complement(4976469..4976990) Escherichia coli IAI39 7151300 YP_002410629.1 CDS insA NC_011750.1 4977282 4977557 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1849492; Product type r : regulator; IS1 repressor protein InsA; KpLE2 phage-like element 4977282..4977557 Escherichia coli IAI39 7151299 YP_002410630.1 CDS insB NC_011750.1 4977476 4977979 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 4977476..4977979 Escherichia coli IAI39 7151790 YP_002410631.1 CDS ECIAI39_4774 NC_011750.1 4978466 4979356 R Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 complement(4978466..4979356) Escherichia coli IAI39 7151801 YP_002410632.1 CDS ECIAI39_4775 NC_011750.1 4979353 4979679 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 complement(4979353..4979679) Escherichia coli IAI39 7150442 YP_002410633.1 CDS ECIAI39_4776 NC_011750.1 4979731 4980747 R Evidence 4 : Homologs of previously reported genes of unknown function; putative restriction system component complement(4979731..4980747) Escherichia coli IAI39 7150443 YP_002410634.1 CDS ECIAI39_4779 NC_011750.1 4982985 4983914 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4982985..4983914) Escherichia coli IAI39 7150446 YP_002410635.1 CDS yjhS NC_011750.1 4984069 4985049 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4984069..4985049) Escherichia coli IAI39 7150447 YP_002410636.1 CDS yjhT NC_011750.1 4985114 4986220 R Evidence 4 : Homologs of previously reported genes of unknown function; N-acetylneuraminic acid mutarotase complement(4985114..4986220) Escherichia coli IAI39 7154323 YP_002410637.1 CDS yjhA NC_011750.1 4986240 4986956 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15743943; Product type t : transporter; N-acetylnuraminic acid outer membrane channel protein complement(4986240..4986956) Escherichia coli IAI39 7154324 YP_002410638.1 CDS ECIAI39_4783 NC_011750.1 4987833 4988150 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4987833..4988150) Escherichia coli IAI39 7154319 YP_002410639.1 CDS fimB NC_011750.1 4988411 4989013 D inversion of on/off regulator of fimA; tyrosine recombinase 4988411..4989013 Escherichia coli IAI39 7150448 YP_002410640.1 CDS fimE NC_011750.1 4989491 4990087 D inversion of on/off regulator of fimA; tyrosine recombinase 4989491..4990087 Escherichia coli IAI39 7151329 YP_002410641.1 CDS ECIAI39_4786 NC_011750.1 4990166 4990381 R hypothetical protein complement(4990166..4990381) Escherichia coli IAI39 7151332 YP_002410642.1 CDS fimA NC_011750.1 4990568 4991116 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6146599, 6147250, 90220509, 93106965, 2858471, 6123483; Product type s : structure; major type 1 subunit fimbrin 4990568..4991116 Escherichia coli IAI39 7150449 YP_002410643.1 CDS fimI NC_011750.1 4991181 4991720 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12897022, 11673421, 6147250; Product type s : structure; type 1 pilus biosynthesis fimbrial protein 4991181..4991720 Escherichia coli IAI39 7151328 YP_002410644.1 CDS fimC NC_011750.1 4991757 4992482 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20450729, 90220509, 93155127, 93391362, 1363735, 8104335, 8636962, 9783748; Product type f : factor; chaperone, periplasmic 4991757..4992482 Escherichia coli IAI39 7151336 YP_002410645.1 CDS fimD NC_011750.1 4992549 4995185 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12842468, 90220509, 1970114; Product type f : factor; outer membrane usher protein, type 1 fimbrial synthesis 4992549..4995185 Escherichia coli IAI39 7151330 YP_002410646.1 CDS fimF NC_011750.1 4995195 4995725 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 92394896, 1970114, 2890081; Product type s : structure; minor component of type 1 fimbriae 4995195..4995725 Escherichia coli IAI39 7151331 YP_002410647.1 CDS fimG NC_011750.1 4995738 4996241 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 92394896, 2890081; Product type s : structure; minor component of type 1 fimbriae 4995738..4996241 Escherichia coli IAI39 7151333 YP_002410648.1 CDS fimH NC_011750.1 4996261 4997163 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 93155127, 93391362, 1971261, 2890081, 2900235; Product type s : structure; minor component of type 1 fimbriae 4996261..4997163 Escherichia coli IAI39 7151334 YP_002410649.1 CDS gntP NC_011750.1 4997413 4998756 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96125229, 15516583, 8550444; Product type t : transporter; fructuronate transporter complement(4997413..4998756) Escherichia coli IAI39 7151335 YP_002410650.1 CDS uxuA NC_011750.1 4999096 5000280 D catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 4999096..5000280 Escherichia coli IAI39 7151570 YP_002410651.1 CDS uxuB NC_011750.1 5000361 5001821 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73203083, 77222076, 14401695; Product type e : enzyme; D-mannonate oxidoreductase, NAD-binding 5000361..5001821 Escherichia coli IAI39 7153121 YP_002410652.1 CDS uxuR NC_011750.1 5002036 5002809 D regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 5002036..5002809 Escherichia coli IAI39 7153122 YP_002410653.1 CDS yjiC NC_011750.1 5002950 5003780 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5002950..5003780) Escherichia coli IAI39 7153123 YP_002410654.1 CDS ECIAI39_4799 NC_011750.1 5003698 5003871 R hypothetical protein complement(5003698..5003871) Escherichia coli IAI39 7154327 YP_002410655.1 CDS iraD NC_011750.1 5004453 5004845 D inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS; DNA replication/recombination/repair protein 5004453..5004845 Escherichia coli IAI39 7150450 YP_002410656.1 CDS yjiE NC_011750.1 5004838 5005749 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(5004838..5005749) Escherichia coli IAI39 7154328 YP_002410657.1 CDS iadA NC_011750.1 5005814 5006986 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95181377, 7876157; Product type e : enzyme; isoaspartyl dipeptidase complement(5005814..5006986) Escherichia coli IAI39 7154329 YP_002410658.1 CDS yjiG NC_011750.1 5006999 5007460 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(5006999..5007460) Escherichia coli IAI39 7151742 YP_002410659.1 CDS yjiH NC_011750.1 5007457 5008140 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(5007457..5008140) Escherichia coli IAI39 7154330 YP_002410660.1 CDS yjiK NC_011750.1 5010202 5011170 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(5010202..5011170) Escherichia coli IAI39 7154333 YP_002410661.1 CDS ECIAI39_4810 NC_011750.1 5011127 5011384 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5011127..5011384) Escherichia coli IAI39 7154334 YP_002410662.1 CDS hgdC NC_011750.1 5011381 5012148 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8365476, 7607244, 15654892; Product type e : enzyme; ATPase, activator of (R)-hydroxyglutaryl-CoA dehydratase complement(5011381..5012148) Escherichia coli IAI39 7150451 YP_002410663.1 CDS yjiM NC_011750.1 5012158 5013309 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3691501, 11106419; Product type pe : putative enzyme; putative 2-hydroxyglutaryl-CoA dehydratase complement(5012158..5013309) Escherichia coli IAI39 7151642 YP_002410664.1 CDS yjiN NC_011750.1 5013425 5014705 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(5013425..5014705) Escherichia coli IAI39 7154335 YP_002410665.1 CDS ECIAI39_4814 NC_011750.1 5014890 5015810 D Evidence 4 : Homologs of previously reported genes of unknown function; putative transposase 5014890..5015810 Escherichia coli IAI39 7154336 YP_002410666.1 CDS ECIAI39_4815 NC_011750.1 5016090 5018312 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5016090..5018312 Escherichia coli IAI39 7150452 YP_002410667.1 CDS yjiW NC_011750.1 5018359 5018700 R involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response; endoribonuclease SymE complement(5018359..5018700) Escherichia coli IAI39 7150453 YP_002410668.1 CDS hsdS NC_011750.1 5018921 5020681 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Type I restriction enzyme EcoAI specificity protein (S protein) (S.EcoAI) complement(5018921..5020681) Escherichia coli IAI39 7152795 YP_002410669.1 CDS hsdM NC_011750.1 5020681 5022186 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8412658, 1409708; Product type e : enzyme; Type I restriction enzyme EcoEI M protein (M.EcoEI) complement(5020681..5022186) Escherichia coli IAI39 7151679 YP_002410670.1 CDS hsdR NC_011750.1 5022217 5024649 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9837717, 10373579, 10733903, 8412658; Product type e : enzyme; Type I restriction enzyme EcoAI R protein (R.EcoAI) complement(5022217..5024649) Escherichia coli IAI39 7151677 YP_002410671.1 CDS ECIAI39_4820 NC_011750.1 5024906 5025373 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5024906..5025373 Escherichia coli IAI39 7151678 YP_002410672.1 CDS ECIAI39_4821 NC_011750.1 5025409 5026578 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5025409..5026578 Escherichia coli IAI39 7150454 YP_002410673.1 CDS yjiA NC_011750.1 5026647 5027603 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14696199; Product type pe : putative enzyme; putative GTP-binding protein YjiA complement(5026647..5027603) Escherichia coli IAI39 7150455 YP_002410674.1 CDS yjiX NC_011750.1 5027614 5027817 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5027614..5027817) Escherichia coli IAI39 7154326 YP_002410675.1 CDS yjiY NC_011750.1 5027867 5030017 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(5027867..5030017) Escherichia coli IAI39 7154338 YP_002410676.1 CDS tsr NC_011750.1 5030395 5032059 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20015410, 89034150, 91317710, 10466731, 2033064, 6213619, 6402709, 8384293; Product type r : regulator; methyl-accepting chemotaxis protein I, serine sensor receptor 5030395..5032059 Escherichia coli IAI39 7154339 YP_002410677.1 CDS ECIAI39_4826 NC_011750.1 5032102 5033373 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative C4-dicarboxylate transporter large permease complement(5032102..5033373) Escherichia coli IAI39 7153048 YP_002410678.1 CDS ECIAI39_4827 NC_011750.1 5033481 5033843 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative tripartite ATP-independent periplasmic transporter (dctQ-like) complement(5033481..5033843) Escherichia coli IAI39 7150456 YP_002410679.1 CDS ECIAI39_4828 NC_011750.1 5033907 5034878 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative C4-dicarboxylate-binding periplasmic protein complement(5033907..5034878) Escherichia coli IAI39 7150457 YP_002410680.1 CDS ECIAI39_4829 NC_011750.1 5035548 5037221 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter; putative Na(+)/H(+) exchanger 5035548..5037221 Escherichia coli IAI39 7150458 YP_002410681.1 CDS yjjM NC_011750.1 5037392 5038297 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator complement(5037392..5038297) Escherichia coli IAI39 7150459 YP_002410682.1 CDS mdoB NC_011750.1 5039598 5041889 R catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I complement(5039598..5041889) Escherichia coli IAI39 7154346 YP_002410683.1 CDS yjjA NC_011750.1 5042143 5042637 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5042143..5042637) Escherichia coli IAI39 7152024 YP_002410684.1 CDS dnaC NC_011750.1 5042686 5043423 R acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC complement(5042686..5043423) Escherichia coli IAI39 7154340 YP_002410685.1 CDS dnaT NC_011750.1 5043426 5043965 R This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI complement(5043426..5043965) Escherichia coli IAI39 7151155 YP_002410686.2 CDS ECIAI39_4836 NC_011750.1 5044073 5044546 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5044073..5044546) Escherichia coli IAI39 7151162 YP_002410687.1 CDS yjjP NC_011750.1 5044537 5045307 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : putative membrane component; hypothetical protein complement(5044537..5045307) Escherichia coli IAI39 7150460 YP_002410688.1 CDS yjjQ NC_011750.1 5045927 5046652 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator; putative DNA-binding transcriptional regulator 5045927..5046652 Escherichia coli IAI39 7154347 YP_002410689.1 CDS bglJ NC_011750.1 5046664 5047287 D regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; DNA-binding transcriptional activator BglJ 5046664..5047287 Escherichia coli IAI39 7154348 YP_002410690.1 CDS fhuF NC_011750.1 5047325 5048113 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11931550, 14756576, 3323834, 9990318; Product type c : carrier; ferric iron reductase involved in ferric hydroximate transport complement(5047325..5048113) Escherichia coli IAI39 7150860 YP_002410691.1 CDS ECIAI39_4841 NC_011750.1 5048143 5048490 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5048143..5048490 Escherichia coli IAI39 7151320 YP_002410692.1 CDS rsmC NC_011750.1 5049051 5050082 R 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase complement(5049051..5050082) Escherichia coli IAI39 7150585 YP_002410693.1 CDS holD NC_011750.1 5050185 5050598 D with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 5050185..5050598 Escherichia coli IAI39 7152744 YP_002410694.1 CDS rimI NC_011750.1 5050567 5051013 D alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 5050567..5051013 Escherichia coli IAI39 7151670 YP_002410695.1 CDS yjjG NC_011750.1 5051028 5051705 D manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 5051028..5051705 Escherichia coli IAI39 7152634 YP_002410696.1 CDS ECIAI39_4846 NC_011750.1 5052091 5053314 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative integrase 5052091..5053314 Escherichia coli IAI39 7154341 YP_002410697.1 CDS ECIAI39_4847 NC_011750.1 5053487 5054740 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5053487..5054740 Escherichia coli IAI39 7150462 YP_002410698.1 CDS yfdT NC_011750.1 5055217 5055564 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(5055217..5055564) Escherichia coli IAI39 7150463 YP_002410699.1 CDS ECIAI39_4849 NC_011750.1 5055561 5056439 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phosphoadenosine phosphosulfate reductase from phage origin complement(5055561..5056439) Escherichia coli IAI39 7153856 YP_002410700.1 CDS yfdR NC_011750.1 5056461 5057018 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(5056461..5057018) Escherichia coli IAI39 7150464 YP_002410701.1 CDS yfdQ NC_011750.1 5057084 5057908 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(5057084..5057908) Escherichia coli IAI39 7153855 YP_002410702.1 CDS ECIAI39_4852 NC_011750.1 5057974 5058522 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5057974..5058522) Escherichia coli IAI39 7153854 YP_002410703.1 CDS ymfK NC_011750.1 5059082 5059756 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12878731, 13129938, 9689094; Product type h : extrachromosomal origin; repressor protein phage e14; e14 prophage complement(5059082..5059756) Escherichia coli IAI39 7150465 YP_002410704.1 CDS ymfT NC_011750.1 5059847 5060047 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA-binding transcriptional regulator; e14 prophage 5059847..5060047 Escherichia coli IAI39 7154388 YP_002410705.1 CDS ECIAI39_4856 NC_011750.1 5060309 5060635 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS629 5060309..5060635 Escherichia coli IAI39 7154389 YP_002410706.1 CDS ECIAI39_4857 NC_011750.1 5060632 5061522 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS629 5060632..5061522 Escherichia coli IAI39 7150466 YP_002410707.1 CDS ECIAI39_4860 NC_011750.1 5061952 5062788 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Immunity region from phage 5061952..5062788 Escherichia coli IAI39 7154390 YP_002410708.1 CDS ECIAI39_4861 NC_011750.1 5062781 5063017 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5062781..5063017 Escherichia coli IAI39 7150468 YP_002410709.1 CDS ECIAI39_4862 NC_011750.1 5063014 5063832 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative replication protein from phage 5063014..5063832 Escherichia coli IAI39 7150469 YP_002410710.1 CDS ECIAI39_4863 NC_011750.1 5064290 5064976 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative phage AdoMet-dependent methyltransferase 5064290..5064976 Escherichia coli IAI39 7150470 YP_002410711.1 CDS ECIAI39_4864 NC_011750.1 5064973 5065299 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative LexA repressor 5064973..5065299 Escherichia coli IAI39 7150471 YP_002410712.1 CDS rusA NC_011750.1 5065296 5065685 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Crossover junction endodeoxyribonuclease 5065296..5065685 Escherichia coli IAI39 7150472 YP_002410713.1 CDS ECIAI39_4866 NC_011750.1 5065705 5066514 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative KilA protein; KilA-N domain 5065705..5066514 Escherichia coli IAI39 7152764 YP_002410714.1 CDS ECIAI39_4867 NC_011750.1 5066516 5067511 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5066516..5067511 Escherichia coli IAI39 7150473 YP_002410715.1 CDS ydfT NC_011750.1 5067525 5068277 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor; putative antitermination protein Q; Qin prophage 5067525..5068277 Escherichia coli IAI39 7150474 YP_002410716.1 CDS ECIAI39_4869 NC_011750.1 5068558 5068983 D hypothetical protein 5068558..5068983 Escherichia coli IAI39 7153559 YP_002410717.1 CDS ECIAI39_4870 NC_011750.1 5069183 5069410 D hypothetical protein 5069183..5069410 Escherichia coli IAI39 7150475 YP_002410718.1 CDS ECIAI39_4871 NC_011750.1 5069682 5070200 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5069682..5070200 Escherichia coli IAI39 7150476 YP_002410719.1 CDS ECIAI39_4872 NC_011750.1 5070219 5071439 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative transposase 5070219..5071439 Escherichia coli IAI39 7150477 YP_002410720.1 CDS ECIAI39_4873 NC_011750.1 5071451 5072506 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA adenine methyltransferase ( DNA methylase) from phage origin 5071451..5072506 Escherichia coli IAI39 7150478 YP_002410721.1 CDS essD NC_011750.1 5072573 5072788 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019562; Product type pe : putative enzyme; putative phage lysis protein S; DLP12 prophage 5072573..5072788 Escherichia coli IAI39 7150479 YP_002410722.1 CDS ybcS NC_011750.1 5072788 5073285 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3017988; Product type pe : putative enzyme; putative lysozyme; DLP12 prophage 5072788..5073285 Escherichia coli IAI39 7151240 YP_002410723.1 CDS Rz NC_011750.1 5073270 5073749 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Endopeptidase from phage origin (Lysis protein Rz) 5073270..5073749 Escherichia coli IAI39 7153302 YP_002410724.1 CDS ECIAI39_4877 NC_011750.1 5074408 5074815 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5074408..5074815 Escherichia coli IAI39 7152796 YP_002410725.1 CDS ECIAI39_4878 NC_011750.1 5074967 5075461 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 5074967..5075461 Escherichia coli IAI39 7150480 YP_002410726.1 CDS ECIAI39_4879 NC_011750.1 5075461 5077563 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative DNA packaging protein of putative prophage ( terminase large subunit) 5075461..5077563 Escherichia coli IAI39 7150481 YP_002410727.1 CDS ECIAI39_4880 NC_011750.1 5077554 5077772 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 5077554..5077772 Escherichia coli IAI39 7150482 YP_002410728.1 CDS ECIAI39_4881 NC_011750.1 5077700 5079280 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative portal protein (head-tail preconnector protein) from putative prophage 5077700..5079280 Escherichia coli IAI39 7150483 YP_002410729.1 CDS ECIAI39_4882 NC_011750.1 5079129 5081252 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative ATP-dependent Clp protease proteolytic subunit 5079129..5081252 Escherichia coli IAI39 7150484 YP_002410730.1 CDS ECIAI39_4883 NC_011750.1 5081294 5081662 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 5081294..5081662 Escherichia coli IAI39 7150485 YP_002410731.1 CDS ECIAI39_4884 NC_011750.1 5081655 5081930 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 5081655..5081930 Escherichia coli IAI39 7150486 YP_002410732.1 CDS ECIAI39_4885 NC_011750.1 5081942 5082520 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein Z (GPZ) of prophage 5081942..5082520 Escherichia coli IAI39 7150487 YP_002410733.1 CDS ECIAI39_4886 NC_011750.1 5082505 5082918 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein U 5082505..5082918 Escherichia coli IAI39 7150488 YP_002410734.1 CDS ECIAI39_4887 NC_011750.1 5082854 5083672 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; major tail protein V 5082854..5083672 Escherichia coli IAI39 7150489 YP_002410735.1 CDS ECIAI39_4888 NC_011750.1 5083691 5084119 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative minor tail component of putative prophage 5083691..5084119 Escherichia coli IAI39 7150490 YP_002410736.1 CDS ECIAI39_4889 NC_011750.1 5084128 5084457 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative minor tail protein T of putative prophage 5084128..5084457 Escherichia coli IAI39 7150491 YP_002410737.1 CDS ECIAI39_4890 NC_011750.1 5084399 5087494 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail length tape measure protein from putative prophage 5084399..5087494 Escherichia coli IAI39 7150492 YP_002410738.1 CDS ECIAI39_4891 NC_011750.1 5087494 5087823 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein M 5087494..5087823 Escherichia coli IAI39 7150493 YP_002410739.1 CDS ECIAI39_4892 NC_011750.1 5087833 5088531 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; minor tail protein L 5087833..5088531 Escherichia coli IAI39 7150494 YP_002410740.1 CDS ECIAI39_4893 NC_011750.1 5088537 5089280 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative tail fiber component K of prophage 5088537..5089280 Escherichia coli IAI39 7150495 YP_002410741.1 CDS ECIAI39_4894 NC_011750.1 5089178 5089825 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail assembly protein I from putative prophage 5089178..5089825 Escherichia coli IAI39 7150496 YP_002410742.1 CDS ECIAI39_4895 NC_011750.1 5089886 5093584 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J 5089886..5093584 Escherichia coli IAI39 7150497 YP_002410743.1 CDS ECIAI39_4896 NC_011750.1 5093652 5094251 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; putative Lom-like outer membrane protein of prophage 5093652..5094251 Escherichia coli IAI39 7150498 YP_002410744.1 CDS ECIAI39_4897 NC_011750.1 5094403 5096460 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 5094403..5096460 Escherichia coli IAI39 7150499 YP_002410745.1 CDS ECIAI39_4898 NC_011750.1 5096457 5096735 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5096457..5096735 Escherichia coli IAI39 7150500 YP_002410746.1 CDS ECIAI39_4899 NC_011750.1 5096745 5097038 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 5096745..5097038 Escherichia coli IAI39 7150501 YP_002410747.1 CDS ECIAI39_4900 NC_011750.1 5097290 5098666 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative retron-type reverse transcriptase complement(5097290..5098666) Escherichia coli IAI39 7150502 YP_002410748.1 CDS ECIAI39_4901 NC_011750.1 5098638 5099342 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(5098638..5099342) Escherichia coli IAI39 7150503 YP_002410749.1 CDS ECIAI39_4902 NC_011750.1 5099434 5099535 R Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; putative DNA damage-inducible protein of the DinI-like family from putative prophage (fragment) complement(5099434..5099535) Escherichia coli IAI39 7150504 YP_002410750.1 CDS prfC NC_011750.1 5099846 5101459 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 5099846..5101459 Escherichia coli IAI39 7150505 YP_002410751.1 CDS osmY NC_011750.1 5101852 5102457 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1317380, 8253679, 9298646, 9600841; Product type cp : cell process; periplasmic protein 5101852..5102457 Escherichia coli IAI39 7152474 YP_002410752.1 CDS ytjA NC_011750.1 5102566 5102745 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5102566..5102745 Escherichia coli IAI39 7152311 YP_002410753.1 CDS yjjU NC_011750.1 5102867 5103940 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative esterase 5102867..5103940 Escherichia coli IAI39 7154584 YP_002410754.1 CDS yjjV NC_011750.1 5103937 5104716 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative deoxyribonuclease YjjV 5103937..5104716 Escherichia coli IAI39 7154349 YP_002410755.1 CDS ECIAI39_4908 NC_011750.1 5104776 5105306 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF A, IS1397 5104776..5105306 Escherichia coli IAI39 7154350 YP_002410756.1 CDS ECIAI39_4909 NC_011750.1 5105411 5106133 D Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme; transposase ORF B, IS3 family, IS150 group 5105411..5106133 Escherichia coli IAI39 7150506 YP_002410757.1 CDS yjjW NC_011750.1 5106269 5107132 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme; putative pyruvate formate lyase activating enzyme complement(5106269..5107132) Escherichia coli IAI39 7150507 YP_002410758.1 CDS deoC NC_011750.1 5108914 5109693 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 5108914..5109693 Escherichia coli IAI39 7154343 YP_002410759.1 CDS deoA NC_011750.1 5109771 5111093 D Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 5109771..5111093 Escherichia coli IAI39 7151119 YP_002410760.1 CDS deoB NC_011750.1 5111145 5112368 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 5111145..5112368 Escherichia coli IAI39 7151117 YP_002410761.1 CDS deoD NC_011750.1 5112425 5113144 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 5112425..5113144 Escherichia coli IAI39 7151118 YP_002410762.1 CDS ECIAI39_4917 NC_011750.1 5113305 5113568 R Evidence 4 : Homologs of previously reported genes of unknown function; putative transcriptional regulator complement(5113305..5113568) Escherichia coli IAI39 7151120 YP_002410763.1 CDS lplA NC_011750.1 5113600 5114616 R Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; lipoate-protein ligase A complement(5113600..5114616) Escherichia coli IAI39 7150508 YP_002410764.1 CDS ytjB NC_011750.1 5114644 5115288 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2684780; hypothetical protein complement(5114644..5115288) Escherichia coli IAI39 7151961 YP_002410765.1 CDS serB NC_011750.1 5115394 5116362 D catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 5115394..5116362 Escherichia coli IAI39 7154585 YP_002410766.1 CDS radA NC_011750.1 5116411 5117793 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 5116411..5117793 Escherichia coli IAI39 7152831 YP_002410767.1 CDS nadR NC_011750.1 5117814 5119046 D catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 5117814..5119046 Escherichia coli IAI39 7152565 YP_002410768.1 CDS ECIAI39_4923 NC_011750.1 5119080 5119364 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5119080..5119364 Escherichia coli IAI39 7152170 YP_002410769.1 CDS yjjK NC_011750.1 5119420 5121087 R ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein complement(5119420..5121087) Escherichia coli IAI39 7150509 YP_002410770.1 CDS slt NC_011750.1 5121298 5123235 D catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 5121298..5123235 Escherichia coli IAI39 7154344 YP_002410771.1 CDS trpR NC_011750.1 5123325 5123651 D When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 5123325..5123651 Escherichia coli IAI39 7152859 YP_002410772.1 CDS yjjX NC_011750.1 5123645 5124169 R pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase complement(5123645..5124169) Escherichia coli IAI39 7153037 YP_002410773.1 CDS ytjC NC_011750.1 5124212 5124859 D catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 5124212..5124859 Escherichia coli IAI39 7154352 YP_002410774.1 CDS rob NC_011750.1 5124856 5125725 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20264525, 20309711, 93194823, 96405618, 8449900; Product type r : regulator; DNA-binding transcriptional activator complement(5124856..5125725) Escherichia coli IAI39 7154586 YP_002410775.1 CDS creA NC_011750.1 5125936 5126409 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3531171, 8449900; hypothetical protein 5125936..5126409 Escherichia coli IAI39 7152664 YP_002410776.1 CDS creB NC_011750.1 5126422 5127111 D response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 5126422..5127111 Escherichia coli IAI39 7150994 YP_002410777.1 CDS creC NC_011750.1 5127111 5128535 D part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 5127111..5128535 Escherichia coli IAI39 7150995 YP_002410778.1 CDS creD NC_011750.1 5128593 5129945 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88216172, 2835585, 2984198, 3531171; Product type m : membrane component; hypothetical protein 5128593..5129945 Escherichia coli IAI39 7150996 YP_002410779.1 CDS arcA NC_011750.1 5130005 5130721 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15028693, 21167794, 21317451, 91008980, 91358353, 92380937, 9514749, 9632255, 2984198, 7565118, 9298646; Product type r : regulator; two-component response regulator complement(5130005..5130721) Escherichia coli IAI39 7150997 YP_002410780.1 CDS yjtD NC_011750.1 5131357 5132043 D member of the SPOUT superfamily of methyltransferases; putative RNA methyltransferase 5131357..5132043 Escherichia coli IAI39 7150756 ECIAI39_tRNA88 tRNA ECIAI39_tRNA88 NC_011750.1 387476 387556 R tRNA-OTHER complement(387476..387556) Escherichia coli IAI39 7153253 ECIAI39_tRNA87 tRNA ECIAI39_tRNA87 NC_011750.1 445001 445076 R tRNA-Thr complement(445001..445076) Escherichia coli IAI39 7149555 ECIAI39_tRNA86 tRNA ECIAI39_tRNA86 NC_011750.1 469047 469123 R tRNA-Asp complement(469047..469123) Escherichia coli IAI39 7153235 ECIAI39_tRNA85 tRNA ECIAI39_tRNA85 NC_011750.1 477271 477347 R tRNA-Asp complement(477271..477347) Escherichia coli IAI39 7151146 ECIAI39_tRNA84 tRNA ECIAI39_tRNA84 NC_011750.1 480691 480766 R tRNA-Ala complement(480691..480766) Escherichia coli IAI39 7149976 ECIAI39_tRNA83 tRNA ECIAI39_tRNA83 NC_011750.1 480809 480885 R tRNA-Ile complement(480809..480885) Escherichia coli IAI39 7150633 ECIAI39_tRNA1 tRNA ECIAI39_tRNA1 NC_011750.1 532503 532579 D tRNA-Arg 532503..532579 Escherichia coli IAI39 7151337 ECIAI39_tRNA82 tRNA ECIAI39_tRNA82 NC_011750.1 665424 665498 R tRNA-Gln complement(665424..665498) Escherichia coli IAI39 7153073 ECIAI39_tRNA81 tRNA ECIAI39_tRNA81 NC_011750.1 665536 665610 R tRNA-Gln complement(665536..665610) Escherichia coli IAI39 7150631 ECIAI39_tRNA80 tRNA ECIAI39_tRNA80 NC_011750.1 665659 665735 R tRNA-Met complement(665659..665735) Escherichia coli IAI39 7150630 ECIAI39_tRNA79 tRNA ECIAI39_tRNA79 NC_011750.1 665751 665825 R tRNA-Gln complement(665751..665825) Escherichia coli IAI39 7150629 ECIAI39_tRNA78 tRNA ECIAI39_tRNA78 NC_011750.1 665860 665934 R tRNA-Gln complement(665860..665934) Escherichia coli IAI39 7150627 ECIAI39_tRNA77 tRNA ECIAI39_tRNA77 NC_011750.1 665958 666042 R tRNA-Leu complement(665958..666042) Escherichia coli IAI39 7150626 ECIAI39_tRNA76 tRNA ECIAI39_tRNA76 NC_011750.1 666051 666127 R tRNA-Met complement(666051..666127) Escherichia coli IAI39 7150625 ECIAI39_tRNA2 tRNA ECIAI39_tRNA2 NC_011750.1 759971 760046 D tRNA-Lys 759971..760046 Escherichia coli IAI39 7153333 ECIAI39_tRNA3 tRNA ECIAI39_tRNA3 NC_011750.1 760082 760157 D tRNA-Val 760082..760157 Escherichia coli IAI39 7150562 ECIAI39_tRNA4 tRNA ECIAI39_tRNA4 NC_011750.1 760160 760235 D tRNA-Lys 760160..760235 Escherichia coli IAI39 7150573 ECIAI39_tRNA5 tRNA ECIAI39_tRNA5 NC_011750.1 760287 760362 D tRNA-Val 760287..760362 Escherichia coli IAI39 7150584 ECIAI39_tRNA6 tRNA ECIAI39_tRNA6 NC_011750.1 760366 760441 D tRNA-Lys 760366..760441 Escherichia coli IAI39 7150595 ECIAI39_tRNA7 tRNA ECIAI39_tRNA7 NC_011750.1 760490 760565 D tRNA-Lys 760490..760565 Escherichia coli IAI39 7150606 ECIAI39_tRNA8 tRNA ECIAI39_tRNA8 NC_011750.1 760599 760674 D tRNA-Lys 760599..760674 Escherichia coli IAI39 7150617 ECIAI39_tRNA75 tRNA ECIAI39_tRNA75 NC_011750.1 1118894 1118969 R tRNA-Asn complement(1118894..1118969) Escherichia coli IAI39 7151239 ECIAI39_tRNA74 tRNA ECIAI39_tRNA74 NC_011750.1 1121303 1121378 R tRNA-Asn complement(1121303..1121378) Escherichia coli IAI39 7150904 ECIAI39_tRNA9 tRNA ECIAI39_tRNA9 NC_011750.1 1123127 1123202 D tRNA-Asn 1123127..1123202 Escherichia coli IAI39 7153714 ECIAI39_tRNA73 tRNA ECIAI39_tRNA73 NC_011750.1 1163016 1163091 R tRNA-Asn complement(1163016..1163091) Escherichia coli IAI39 7151828 ECIAI39_tRNA10 tRNA ECIAI39_tRNA10 NC_011750.1 1164083 1164172 D tRNA-Ser 1164083..1164172 Escherichia coli IAI39 7153710 ECIAI39_tRNA11 tRNA ECIAI39_tRNA11 NC_011750.1 1214772 1214847 D tRNA-Gly 1214772..1214847 Escherichia coli IAI39 7152387 ECIAI39_tRNA12 tRNA ECIAI39_tRNA12 NC_011750.1 1214902 1214975 D tRNA-Cys 1214902..1214975 Escherichia coli IAI39 7150553 ECIAI39_tRNA13 tRNA ECIAI39_tRNA13 NC_011750.1 1214988 1215074 D tRNA-Leu 1214988..1215074 Escherichia coli IAI39 7150554 ECIAI39_tRNA72 tRNA ECIAI39_tRNA72 NC_011750.1 1460656 1460732 R tRNA-Val complement(1460656..1460732) Escherichia coli IAI39 7153584 ECIAI39_tRNA71 tRNA ECIAI39_tRNA71 NC_011750.1 1460737 1460813 R tRNA-Val complement(1460737..1460813) Escherichia coli IAI39 7150620 ECIAI39_tRNA70 tRNA ECIAI39_tRNA70 NC_011750.1 1637610 1637694 R tRNA-Tyr complement(1637610..1637694) Escherichia coli IAI39 7152190 ECIAI39_tRNA69 tRNA ECIAI39_tRNA69 NC_011750.1 1637729 1637813 R tRNA-Tyr complement(1637729..1637813) Escherichia coli IAI39 7150618 ECIAI39_tRNA14 tRNA ECIAI39_tRNA14 NC_011750.1 2169852 2169939 D tRNA-Ser 2169852..2169939 Escherichia coli IAI39 7153435 ECIAI39_tRNA15 tRNA ECIAI39_tRNA15 NC_011750.1 2222795 2222882 D tRNA-Ser 2222795..2222882 Escherichia coli IAI39 7151697 ECIAI39_tRNA16 tRNA ECIAI39_tRNA16 NC_011750.1 2331206 2331293 D tRNA-Ser 2331206..2331293 Escherichia coli IAI39 7151777 ECIAI39_tRNA17 tRNA ECIAI39_tRNA17 NC_011750.1 2400367 2400443 D tRNA-Pro 2400367..2400443 Escherichia coli IAI39 7153794 ECIAI39_tRNA18 tRNA ECIAI39_tRNA18 NC_011750.1 2588498 2588572 D tRNA-Arg 2588498..2588572 Escherichia coli IAI39 7153851 ECIAI39_tRNA68 tRNA ECIAI39_tRNA68 NC_011750.1 2639851 2639926 R tRNA-Ala complement(2639851..2639926) Escherichia coli IAI39 7153861 ECIAI39_tRNA67 tRNA ECIAI39_tRNA67 NC_011750.1 2639966 2640041 R tRNA-Ala complement(2639966..2640041) Escherichia coli IAI39 7150615 ECIAI39_tRNA19 tRNA ECIAI39_tRNA19 NC_011750.1 2644486 2644561 D tRNA-Val 2644486..2644561 Escherichia coli IAI39 7151557 ECIAI39_tRNA20 tRNA ECIAI39_tRNA20 NC_011750.1 2644606 2644681 D tRNA-Val 2644606..2644681 Escherichia coli IAI39 7150561 ECIAI39_tRNA21 tRNA ECIAI39_tRNA21 NC_011750.1 2644726 2644801 D tRNA-Val 2644726..2644801 Escherichia coli IAI39 7150563 ECIAI39_tRNA22 tRNA ECIAI39_tRNA22 NC_011750.1 2644847 2644922 D tRNA-Val 2644847..2644922 Escherichia coli IAI39 7150564 ECIAI39_tRNA23 tRNA ECIAI39_tRNA23 NC_011750.1 2644927 2645002 D tRNA-Lys 2644927..2645002 Escherichia coli IAI39 7150565 ECIAI39_tRNA24 tRNA ECIAI39_tRNA24 NC_011750.1 2778079 2778155 D tRNA-Arg 2778079..2778155 Escherichia coli IAI39 7150030 ECIAI39_tRNA66 tRNA ECIAI39_tRNA66 NC_011750.1 2905324 2905399 R tRNA-Glu complement(2905324..2905399) Escherichia coli IAI39 7149975 ECIAI39_tRNA65 tRNA ECIAI39_tRNA65 NC_011750.1 2951866 2951941 R tRNA-Met complement(2951866..2951941) Escherichia coli IAI39 7150079 ECIAI39_tRNA64 tRNA ECIAI39_tRNA64 NC_011750.1 2988502 2988578 R tRNA-Arg complement(2988502..2988578) Escherichia coli IAI39 7154497 ECIAI39_tRNA63 tRNA ECIAI39_tRNA63 NC_011750.1 2988641 2988717 R tRNA-Arg complement(2988641..2988717) Escherichia coli IAI39 7150611 ECIAI39_tRNA62 tRNA ECIAI39_tRNA62 NC_011750.1 2988782 2988858 R tRNA-Arg complement(2988782..2988858) Escherichia coli IAI39 7150610 ECIAI39_tRNA61 tRNA ECIAI39_tRNA61 NC_011750.1 2988923 2988999 R tRNA-Arg complement(2988923..2988999) Escherichia coli IAI39 7150609 ECIAI39_tRNA60 tRNA ECIAI39_tRNA60 NC_011750.1 2989003 2989095 R tRNA-Ser complement(2989003..2989095) Escherichia coli IAI39 7150608 ECIAI39_tRNA59 tRNA ECIAI39_tRNA59 NC_011750.1 3098396 3098472 R tRNA-Pro complement(3098396..3098472) Escherichia coli IAI39 7150800 ECIAI39_tRNA58 tRNA ECIAI39_tRNA58 NC_011750.1 3098515 3098601 R tRNA-Leu complement(3098515..3098601) Escherichia coli IAI39 7150605 ECIAI39_tRNA57 tRNA ECIAI39_tRNA57 NC_011750.1 3098622 3098697 R tRNA-His complement(3098622..3098697) Escherichia coli IAI39 7150604 ECIAI39_tRNA56 tRNA ECIAI39_tRNA56 NC_011750.1 3098756 3098832 R tRNA-Arg complement(3098756..3098832) Escherichia coli IAI39 7150603 ECIAI39_tRNA55 tRNA ECIAI39_tRNA55 NC_011750.1 3134033 3134108 R tRNA-Trp complement(3134033..3134108) Escherichia coli IAI39 7151621 ECIAI39_tRNA54 tRNA ECIAI39_tRNA54 NC_011750.1 3134117 3134193 R tRNA-Asp complement(3134117..3134193) Escherichia coli IAI39 7150601 ECIAI39_tRNA53 tRNA ECIAI39_tRNA53 NC_011750.1 3137595 3137670 R tRNA-Glu complement(3137595..3137670) Escherichia coli IAI39 7149974 ECIAI39_tRNA52 tRNA ECIAI39_tRNA52 NC_011750.1 3282785 3282860 R tRNA-Ala complement(3282785..3282860) Escherichia coli IAI39 7149973 ECIAI39_tRNA51 tRNA ECIAI39_tRNA51 NC_011750.1 3282903 3282979 R tRNA-Ile complement(3282903..3282979) Escherichia coli IAI39 7150598 ECIAI39_tRNA25 tRNA ECIAI39_tRNA25 NC_011750.1 3376027 3376103 D tRNA-Met 3376027..3376103 Escherichia coli IAI39 7152089 ECIAI39_tRNA26 tRNA ECIAI39_tRNA26 NC_011750.1 3376138 3376214 D tRNA-Met 3376138..3376214 Escherichia coli IAI39 7150568 ECIAI39_tRNA50 tRNA ECIAI39_tRNA50 NC_011750.1 3426272 3426345 R tRNA-Gly complement(3426272..3426345) Escherichia coli IAI39 7150145 ECIAI39_tRNA27 tRNA ECIAI39_tRNA27 NC_011750.1 3545466 3545541 D tRNA-Phe 3545466..3545541 Escherichia coli IAI39 7154514 ECIAI39_tRNA28 tRNA ECIAI39_tRNA28 NC_011750.1 3721345 3721420 D tRNA-Met 3721345..3721420 Escherichia coli IAI39 7154028 ECIAI39_tRNA49 tRNA ECIAI39_tRNA49 NC_011750.1 3827977 3828053 R tRNA-Met complement(3827977..3828053) Escherichia coli IAI39 7154049 ECIAI39_tRNA48 tRNA ECIAI39_tRNA48 NC_011750.1 3831836 3831922 R tRNA-Leu complement(3831836..3831922) Escherichia coli IAI39 7154061 ECIAI39_tRNA47 tRNA ECIAI39_tRNA47 NC_011750.1 3937949 3938024 R tRNA-Thr complement(3937949..3938024) Escherichia coli IAI39 7150511 ECIAI39_tRNA46 tRNA ECIAI39_tRNA46 NC_011750.1 3941334 3941409 R tRNA-Ala complement(3941334..3941409) Escherichia coli IAI39 7149972 ECIAI39_tRNA45 tRNA ECIAI39_tRNA45 NC_011750.1 3941452 3941528 R tRNA-Ile complement(3941452..3941528) Escherichia coli IAI39 7150591 ECIAI39_tRNA44 tRNA ECIAI39_tRNA44 NC_011750.1 4222468 4222544 R tRNA-Pro complement(4222468..4222544) Escherichia coli IAI39 7151166 ECIAI39_tRNA29 tRNA ECIAI39_tRNA29 NC_011750.1 4361397 4361487 D tRNA-Sec 4361397..4361487 Escherichia coli IAI39 7154172 ECIAI39_tRNA30 tRNA ECIAI39_tRNA30 NC_011750.1 4548343 4548418 D tRNA-Glu 4548343..4548418 Escherichia coli IAI39 7149779 ECIAI39_tRNA31 tRNA ECIAI39_tRNA31 NC_011750.1 4555233 4555308 D tRNA-Thr 4555233..4555308 Escherichia coli IAI39 7150973 ECIAI39_tRNA32 tRNA ECIAI39_tRNA32 NC_011750.1 4555317 4555401 D tRNA-Tyr 4555317..4555401 Escherichia coli IAI39 7150575 ECIAI39_tRNA33 tRNA ECIAI39_tRNA33 NC_011750.1 4555518 4555592 D tRNA-Gly 4555518..4555592 Escherichia coli IAI39 7150576 ECIAI39_tRNA34 tRNA ECIAI39_tRNA34 NC_011750.1 4555599 4555674 D tRNA-Thr 4555599..4555674 Escherichia coli IAI39 7150577 ECIAI39_tRNA35 tRNA ECIAI39_tRNA35 NC_011750.1 4594932 4595007 D tRNA-Glu 4594932..4595007 Escherichia coli IAI39 7149780 ECIAI39_tRNA43 tRNA ECIAI39_tRNA43 NC_011750.1 4802111 4802186 R tRNA-Phe complement(4802111..4802186) Escherichia coli IAI39 7151831 ECIAI39_tRNA36 tRNA ECIAI39_tRNA36 NC_011750.1 4831824 4831899 D tRNA-Gly 4831824..4831899 Escherichia coli IAI39 7152307 ECIAI39_tRNA37 tRNA ECIAI39_tRNA37 NC_011750.1 4831936 4832011 D tRNA-Gly 4831936..4832011 Escherichia coli IAI39 7150580 ECIAI39_tRNA38 tRNA ECIAI39_tRNA38 NC_011750.1 4832047 4832122 D tRNA-Gly 4832047..4832122 Escherichia coli IAI39 7150581 ECIAI39_tRNA39 tRNA ECIAI39_tRNA39 NC_011750.1 4950549 4950633 D tRNA-Leu 4950549..4950633 Escherichia coli IAI39 7154310 ECIAI39_tRNA42 tRNA ECIAI39_tRNA42 NC_011750.1 5048529 5048615 R tRNA-Leu complement(5048529..5048615) Escherichia coli IAI39 7150461 ECIAI39_tRNA41 tRNA ECIAI39_tRNA41 NC_011750.1 5048650 5048736 R tRNA-Leu complement(5048650..5048736) Escherichia coli IAI39 7150587 ECIAI39_tRNA40 tRNA ECIAI39_tRNA40 NC_011750.1 5048765 5048851 R tRNA-Leu complement(5048765..5048851) Escherichia coli IAI39 7150586 ECIAI39_5S_6 rRNA ECIAI39_5S_6 NC_011750.1 477400 477519 R ribosomal RNA 5S complement(477400..477519) Escherichia coli IAI39 7150634 ECIAI39_23S_5 rRNA ECIAI39_23S_5 NC_011750.1 477613 480516 R ribosomal RNA 23S complement(477613..480516) Escherichia coli IAI39 7150515 ECIAI39_16S_5 rRNA ECIAI39_16S_5 NC_011750.1 480954 482495 R ribosomal RNA 16S complement(480954..482495) Escherichia coli IAI39 7150632 ECIAI39_5S_5 rRNA ECIAI39_5S_5 NC_011750.1 2902024 2902143 R ribosomal RNA 5S complement(2902024..2902143) Escherichia coli IAI39 7150063 ECIAI39_23S_4 rRNA ECIAI39_23S_4 NC_011750.1 2902235 2905138 R ribosomal RNA 23S complement(2902235..2905138) Escherichia coli IAI39 7150514 ECIAI39_16S_4 rRNA ECIAI39_16S_4 NC_011750.1 2905485 2907026 R ribosomal RNA 16S complement(2905485..2907026) Escherichia coli IAI39 7150613 ECIAI39_5S_4 rRNA ECIAI39_5S_4 NC_011750.1 3134246 3134365 R ribosomal RNA 5S complement(3134246..3134365) Escherichia coli IAI39 7150600 ECIAI39_23S_3 rRNA ECIAI39_23S_3 NC_011750.1 3134459 3137362 R ribosomal RNA 23S complement(3134459..3137362) Escherichia coli IAI39 7150513 ECIAI39_16S_3 rRNA ECIAI39_16S_3 NC_011750.1 3137756 3139297 R ribosomal RNA 16S complement(3137756..3139297) Escherichia coli IAI39 7150599 ECIAI39_5S_3 rRNA ECIAI39_5S_3 NC_011750.1 3279494 3279613 R ribosomal RNA 5S complement(3279494..3279613) Escherichia coli IAI39 7152101 ECIAI39_23S_2 rRNA ECIAI39_23S_2 NC_011750.1 3279707 3282610 R ribosomal RNA 23S complement(3279707..3282610) Escherichia coli IAI39 7150512 ECIAI39_16S_2 rRNA ECIAI39_16S_2 NC_011750.1 3283048 3284589 R ribosomal RNA 16S complement(3283048..3284589) Escherichia coli IAI39 7150597 ECIAI39_5S_2 rRNA ECIAI39_5S_2 NC_011750.1 3937796 3937908 R ribosomal RNA 5S complement(3937796..3937908) Escherichia coli IAI39 7150646 ECIAI39_5S_1 rRNA ECIAI39_5S_1 NC_011750.1 3938037 3938156 R ribosomal RNA 5S complement(3938037..3938156) Escherichia coli IAI39 7150592 ECIAI39_23S_1 rRNA ECIAI39_23S_1 NC_011750.1 3938256 3941159 R ribosomal RNA 23S complement(3938256..3941159) Escherichia coli IAI39 7150510 ECIAI39_16S_1 rRNA ECIAI39_16S_1 NC_011750.1 3941597 3943138 R ribosomal RNA 16S complement(3941597..3943138) Escherichia coli IAI39 7150590 ECIAI39_16S_6 rRNA ECIAI39_16S_6 NC_011750.1 4546716 4548257 D ribosomal RNA 16S 4546716..4548257 Escherichia coli IAI39 7154200 ECIAI39_23S_6 rRNA ECIAI39_23S_6 NC_011750.1 4548651 4551554 D ribosomal RNA 23S 4548651..4551554 Escherichia coli IAI39 7150574 ECIAI39_5S_7 rRNA ECIAI39_5S_7 NC_011750.1 4551648 4551767 D ribosomal RNA 5S 4551648..4551767 Escherichia coli IAI39 7149977 ECIAI39_16S_7 rRNA ECIAI39_16S_7 NC_011750.1 4593305 4594846 D ribosomal RNA 16S 4593305..4594846 Escherichia coli IAI39 7150352 ECIAI39_23S_7 rRNA ECIAI39_23S_7 NC_011750.1 4595193 4598096 D ribosomal RNA 23S 4595193..4598096 Escherichia coli IAI39 7150579 ECIAI39_5S_8 rRNA ECIAI39_5S_8 NC_011750.1 4598194 4598309 D ribosomal RNA 5S 4598194..4598309 Escherichia coli IAI39 7149978