-- dump date 20140619_082459 -- class Genbank::misc_feature -- table misc_feature_note -- id note 714962000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 714962000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 714962000003 putative catalytic residues [active] 714962000004 putative nucleotide binding site [chemical binding]; other site 714962000005 putative aspartate binding site [chemical binding]; other site 714962000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 714962000007 dimer interface [polypeptide binding]; other site 714962000008 putative threonine allosteric regulatory site; other site 714962000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 714962000010 putative threonine allosteric regulatory site; other site 714962000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 714962000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 714962000013 homoserine kinase; Region: thrB; TIGR00191 714962000014 Protein of unknown function; Region: YhfT; pfam10797 714962000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 714962000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 714962000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 714962000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962000019 catalytic residue [active] 714962000020 hypothetical protein; Validated; Region: PRK02101 714962000021 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 714962000022 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 714962000023 transaldolase-like protein; Provisional; Region: PTZ00411 714962000024 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 714962000025 active site 714962000026 dimer interface [polypeptide binding]; other site 714962000027 catalytic residue [active] 714962000028 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 714962000029 MPT binding site; other site 714962000030 trimer interface [polypeptide binding]; other site 714962000031 hypothetical protein; Provisional; Region: PRK10659 714962000032 hypothetical protein; Provisional; Region: PRK10236 714962000033 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 714962000034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 714962000035 hypothetical protein; Provisional; Region: PRK10154 714962000036 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 714962000037 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 714962000038 nucleotide binding site [chemical binding]; other site 714962000039 NEF interaction site [polypeptide binding]; other site 714962000040 SBD interface [polypeptide binding]; other site 714962000041 chaperone protein DnaJ; Provisional; Region: PRK10767 714962000042 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 714962000043 HSP70 interaction site [polypeptide binding]; other site 714962000044 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 714962000045 substrate binding site [polypeptide binding]; other site 714962000046 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 714962000047 Zn binding sites [ion binding]; other site 714962000048 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 714962000049 dimer interface [polypeptide binding]; other site 714962000050 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 714962000051 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 714962000052 Sulfatase; Region: Sulfatase; pfam00884 714962000053 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 714962000054 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 714962000055 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962000056 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 714962000057 putative dimerization interface [polypeptide binding]; other site 714962000058 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 714962000059 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 714962000060 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 714962000061 active site 714962000062 Riboflavin kinase; Region: Flavokinase; smart00904 714962000063 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 714962000064 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 714962000065 HIGH motif; other site 714962000066 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 714962000067 active site 714962000068 KMSKS motif; other site 714962000069 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 714962000070 tRNA binding surface [nucleotide binding]; other site 714962000071 anticodon binding site; other site 714962000072 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 714962000073 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 714962000074 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 714962000075 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 714962000076 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 714962000077 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 714962000078 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 714962000079 active site 714962000080 tetramer interface [polypeptide binding]; other site 714962000081 Protein of unknown function (DUF805); Region: DUF805; pfam05656 714962000082 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 714962000083 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 714962000084 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 714962000085 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 714962000086 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 714962000087 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 714962000088 catalytic site [active] 714962000089 subunit interface [polypeptide binding]; other site 714962000090 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 714962000091 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 714962000092 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 714962000093 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 714962000094 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 714962000095 ATP-grasp domain; Region: ATP-grasp_4; cl17255 714962000096 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 714962000097 IMP binding site; other site 714962000098 dimer interface [polypeptide binding]; other site 714962000099 interdomain contacts; other site 714962000100 partial ornithine binding site; other site 714962000101 Transposase IS200 like; Region: Y1_Tnp; pfam01797 714962000102 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 714962000103 carnitine operon protein CaiE; Provisional; Region: PRK13627 714962000104 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 714962000105 putative trimer interface [polypeptide binding]; other site 714962000106 putative metal binding site [ion binding]; other site 714962000107 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 714962000108 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 714962000109 substrate binding site [chemical binding]; other site 714962000110 oxyanion hole (OAH) forming residues; other site 714962000111 trimer interface [polypeptide binding]; other site 714962000112 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 714962000113 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 714962000114 acyl-activating enzyme (AAE) consensus motif; other site 714962000115 putative AMP binding site [chemical binding]; other site 714962000116 putative active site [active] 714962000117 putative CoA binding site [chemical binding]; other site 714962000118 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 714962000119 CoA-transferase family III; Region: CoA_transf_3; pfam02515 714962000120 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 714962000121 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 714962000122 active site 714962000123 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 714962000124 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 714962000125 Ligand binding site [chemical binding]; other site 714962000126 Electron transfer flavoprotein domain; Region: ETF; pfam01012 714962000127 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 714962000128 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 714962000129 Ligand binding site [chemical binding]; other site 714962000130 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 714962000131 putative oxidoreductase FixC; Provisional; Region: PRK10157 714962000132 ferredoxin-like protein FixX; Provisional; Region: PRK15449 714962000133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962000134 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 714962000135 putative substrate translocation pore; other site 714962000136 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 714962000137 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 714962000138 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 714962000139 TrkA-N domain; Region: TrkA_N; pfam02254 714962000140 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 714962000141 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 714962000142 folate binding site [chemical binding]; other site 714962000143 NADP+ binding site [chemical binding]; other site 714962000144 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 714962000145 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 714962000146 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 714962000147 active site 714962000148 metal binding site [ion binding]; metal-binding site 714962000149 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 714962000150 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 714962000151 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 714962000152 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 714962000153 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 714962000154 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 714962000155 SurA N-terminal domain; Region: SurA_N; pfam09312 714962000156 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 714962000157 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 714962000158 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 714962000159 OstA-like protein; Region: OstA; pfam03968 714962000160 Organic solvent tolerance protein; Region: OstA_C; pfam04453 714962000161 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 714962000162 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 714962000163 putative metal binding site [ion binding]; other site 714962000164 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 714962000165 HSP70 interaction site [polypeptide binding]; other site 714962000166 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 714962000167 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 714962000168 active site 714962000169 ATP-dependent helicase HepA; Validated; Region: PRK04914 714962000170 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714962000171 ATP binding site [chemical binding]; other site 714962000172 putative Mg++ binding site [ion binding]; other site 714962000173 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714962000174 nucleotide binding region [chemical binding]; other site 714962000175 ATP-binding site [chemical binding]; other site 714962000176 DNA polymerase II; Reviewed; Region: PRK05762 714962000177 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 714962000178 active site 714962000179 catalytic site [active] 714962000180 substrate binding site [chemical binding]; other site 714962000181 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 714962000182 active site 714962000183 metal-binding site 714962000184 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 714962000185 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 714962000186 intersubunit interface [polypeptide binding]; other site 714962000187 active site 714962000188 Zn2+ binding site [ion binding]; other site 714962000189 L-arabinose isomerase; Provisional; Region: PRK02929 714962000190 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 714962000191 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 714962000192 trimer interface [polypeptide binding]; other site 714962000193 putative substrate binding site [chemical binding]; other site 714962000194 putative metal binding site [ion binding]; other site 714962000195 ribulokinase; Provisional; Region: PRK04123 714962000196 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 714962000197 N- and C-terminal domain interface [polypeptide binding]; other site 714962000198 active site 714962000199 MgATP binding site [chemical binding]; other site 714962000200 catalytic site [active] 714962000201 metal binding site [ion binding]; metal-binding site 714962000202 carbohydrate binding site [chemical binding]; other site 714962000203 homodimer interface [polypeptide binding]; other site 714962000204 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 714962000205 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 714962000206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962000207 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962000208 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 714962000209 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 714962000210 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 714962000211 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 714962000212 Walker A/P-loop; other site 714962000213 ATP binding site [chemical binding]; other site 714962000214 Q-loop/lid; other site 714962000215 ABC transporter signature motif; other site 714962000216 Walker B; other site 714962000217 D-loop; other site 714962000218 H-loop/switch region; other site 714962000219 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 714962000220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962000221 dimer interface [polypeptide binding]; other site 714962000222 conserved gate region; other site 714962000223 putative PBP binding loops; other site 714962000224 ABC-ATPase subunit interface; other site 714962000225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962000226 dimer interface [polypeptide binding]; other site 714962000227 conserved gate region; other site 714962000228 putative PBP binding loops; other site 714962000229 ABC-ATPase subunit interface; other site 714962000230 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 714962000231 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 714962000232 transcriptional regulator SgrR; Provisional; Region: PRK13626 714962000233 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 714962000234 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 714962000235 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 714962000236 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 714962000237 substrate binding site [chemical binding]; other site 714962000238 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 714962000239 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 714962000240 substrate binding site [chemical binding]; other site 714962000241 ligand binding site [chemical binding]; other site 714962000242 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 714962000243 tartrate dehydrogenase; Region: TTC; TIGR02089 714962000244 2-isopropylmalate synthase; Validated; Region: PRK00915 714962000245 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 714962000246 active site 714962000247 catalytic residues [active] 714962000248 metal binding site [ion binding]; metal-binding site 714962000249 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 714962000250 leu operon leader peptide; Provisional; Region: PRK09925 714962000251 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 714962000252 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962000253 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 714962000254 putative substrate binding pocket [chemical binding]; other site 714962000255 putative dimerization interface [polypeptide binding]; other site 714962000256 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 714962000257 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 714962000258 PYR/PP interface [polypeptide binding]; other site 714962000259 dimer interface [polypeptide binding]; other site 714962000260 TPP binding site [chemical binding]; other site 714962000261 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 714962000262 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 714962000263 TPP-binding site [chemical binding]; other site 714962000264 dimer interface [polypeptide binding]; other site 714962000265 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 714962000266 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 714962000267 putative valine binding site [chemical binding]; other site 714962000268 dimer interface [polypeptide binding]; other site 714962000269 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 714962000270 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 714962000271 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714962000272 DNA binding site [nucleotide binding] 714962000273 domain linker motif; other site 714962000274 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 714962000275 dimerization interface [polypeptide binding]; other site 714962000276 ligand binding site [chemical binding]; other site 714962000277 mraZ protein; Region: TIGR00242 714962000278 MraZ protein; Region: MraZ; pfam02381 714962000279 MraZ protein; Region: MraZ; pfam02381 714962000280 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 714962000281 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 714962000282 cell division protein FtsL; Provisional; Region: PRK10772 714962000283 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 714962000284 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714962000285 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714962000286 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 714962000287 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 714962000288 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714962000289 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714962000290 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 714962000291 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 714962000292 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714962000293 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714962000294 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 714962000295 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 714962000296 Mg++ binding site [ion binding]; other site 714962000297 putative catalytic motif [active] 714962000298 putative substrate binding site [chemical binding]; other site 714962000299 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 714962000300 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714962000301 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714962000302 cell division protein FtsW; Provisional; Region: PRK10774 714962000303 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 714962000304 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 714962000305 active site 714962000306 homodimer interface [polypeptide binding]; other site 714962000307 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 714962000308 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 714962000309 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714962000310 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714962000311 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 714962000312 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 714962000313 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 714962000314 cell division protein FtsQ; Provisional; Region: PRK10775 714962000315 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 714962000316 Cell division protein FtsQ; Region: FtsQ; pfam03799 714962000317 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 714962000318 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 714962000319 Cell division protein FtsA; Region: FtsA; pfam14450 714962000320 cell division protein FtsZ; Validated; Region: PRK09330 714962000321 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 714962000322 nucleotide binding site [chemical binding]; other site 714962000323 SulA interaction site; other site 714962000324 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 714962000325 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 714962000326 SecA regulator SecM; Provisional; Region: PRK02943 714962000327 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 714962000328 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 714962000329 SEC-C motif; Region: SEC-C; pfam02810 714962000330 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 714962000331 active site 714962000332 8-oxo-dGMP binding site [chemical binding]; other site 714962000333 nudix motif; other site 714962000334 metal binding site [ion binding]; metal-binding site 714962000335 DNA gyrase inhibitor; Reviewed; Region: PRK00418 714962000336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 714962000337 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 714962000338 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 714962000339 CoA-binding site [chemical binding]; other site 714962000340 ATP-binding [chemical binding]; other site 714962000341 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 714962000342 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 714962000343 active site 714962000344 type IV pilin biogenesis protein; Provisional; Region: PRK10573 714962000345 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 714962000346 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 714962000347 hypothetical protein; Provisional; Region: PRK10436 714962000348 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 714962000349 Walker A motif; other site 714962000350 ATP binding site [chemical binding]; other site 714962000351 Walker B motif; other site 714962000352 putative major pilin subunit; Provisional; Region: PRK10574 714962000353 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 714962000354 Pilin (bacterial filament); Region: Pilin; pfam00114 714962000355 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 714962000356 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 714962000357 dimerization interface [polypeptide binding]; other site 714962000358 active site 714962000359 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 714962000360 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 714962000361 amidase catalytic site [active] 714962000362 Zn binding residues [ion binding]; other site 714962000363 substrate binding site [chemical binding]; other site 714962000364 regulatory protein AmpE; Provisional; Region: PRK10987 714962000365 aromatic amino acid transporter; Provisional; Region: PRK10238 714962000366 Protein of unknown function (DUF796); Region: DUF796; cl01226 714962000367 S-type Pyocin; Region: Pyocin_S; pfam06958 714962000368 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 714962000369 active site 714962000370 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 714962000371 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 714962000372 Transcriptional regulators [Transcription]; Region: FadR; COG2186 714962000373 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962000374 DNA-binding site [nucleotide binding]; DNA binding site 714962000375 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 714962000376 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 714962000377 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 714962000378 dimer interface [polypeptide binding]; other site 714962000379 TPP-binding site [chemical binding]; other site 714962000380 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 714962000381 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 714962000382 E3 interaction surface; other site 714962000383 lipoyl attachment site [posttranslational modification]; other site 714962000384 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 714962000385 E3 interaction surface; other site 714962000386 lipoyl attachment site [posttranslational modification]; other site 714962000387 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 714962000388 E3 interaction surface; other site 714962000389 lipoyl attachment site [posttranslational modification]; other site 714962000390 e3 binding domain; Region: E3_binding; pfam02817 714962000391 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 714962000392 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 714962000393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 714962000394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714962000395 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 714962000396 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 714962000397 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 714962000398 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 714962000399 substrate binding site [chemical binding]; other site 714962000400 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 714962000401 substrate binding site [chemical binding]; other site 714962000402 ligand binding site [chemical binding]; other site 714962000403 hypothetical protein; Provisional; Region: PRK05248 714962000404 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 714962000405 spermidine synthase; Provisional; Region: PRK00811 714962000406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962000407 S-adenosylmethionine binding site [chemical binding]; other site 714962000408 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 714962000409 multicopper oxidase; Provisional; Region: PRK10965 714962000410 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 714962000411 Multicopper oxidase; Region: Cu-oxidase; pfam00394 714962000412 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 714962000413 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 714962000414 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 714962000415 Trp docking motif [polypeptide binding]; other site 714962000416 putative active site [active] 714962000417 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714962000418 active site 714962000419 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 714962000420 active site clefts [active] 714962000421 zinc binding site [ion binding]; other site 714962000422 dimer interface [polypeptide binding]; other site 714962000423 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714962000424 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 714962000425 Walker A/P-loop; other site 714962000426 ATP binding site [chemical binding]; other site 714962000427 Q-loop/lid; other site 714962000428 ABC transporter signature motif; other site 714962000429 Walker B; other site 714962000430 D-loop; other site 714962000431 H-loop/switch region; other site 714962000432 inner membrane transport permease; Provisional; Region: PRK15066 714962000433 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 714962000434 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 714962000435 active pocket/dimerization site; other site 714962000436 active site 714962000437 phosphorylation site [posttranslational modification] 714962000438 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 714962000439 putative active site [active] 714962000440 putative metal binding site [ion binding]; other site 714962000441 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 714962000442 tetramerization interface [polypeptide binding]; other site 714962000443 active site 714962000444 Uncharacterized conserved protein [Function unknown]; Region: COG5464 714962000445 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 714962000446 pantoate--beta-alanine ligase; Region: panC; TIGR00018 714962000447 Pantoate-beta-alanine ligase; Region: PanC; cd00560 714962000448 active site 714962000449 ATP-binding site [chemical binding]; other site 714962000450 pantoate-binding site; other site 714962000451 HXXH motif; other site 714962000452 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 714962000453 oligomerization interface [polypeptide binding]; other site 714962000454 active site 714962000455 metal binding site [ion binding]; metal-binding site 714962000456 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 714962000457 putative fimbrial protein StaF; Provisional; Region: PRK15262 714962000458 putative fimbrial protein StaE; Provisional; Region: PRK15263 714962000459 Fimbrial protein; Region: Fimbrial; cl01416 714962000460 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 714962000461 PapC N-terminal domain; Region: PapC_N; pfam13954 714962000462 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 714962000463 PapC C-terminal domain; Region: PapC_C; pfam13953 714962000464 putative chaperone protein EcpD; Provisional; Region: PRK09926 714962000465 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 714962000466 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 714962000467 Fimbrial protein; Region: Fimbrial; cl01416 714962000468 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 714962000469 catalytic center binding site [active] 714962000470 ATP binding site [chemical binding]; other site 714962000471 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 714962000472 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 714962000473 active site 714962000474 NTP binding site [chemical binding]; other site 714962000475 metal binding triad [ion binding]; metal-binding site 714962000476 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 714962000477 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 714962000478 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 714962000479 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 714962000480 active site 714962000481 nucleotide binding site [chemical binding]; other site 714962000482 HIGH motif; other site 714962000483 KMSKS motif; other site 714962000484 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 714962000485 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 714962000486 2'-5' RNA ligase; Provisional; Region: PRK15124 714962000487 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 714962000488 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 714962000489 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 714962000490 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714962000491 ATP binding site [chemical binding]; other site 714962000492 putative Mg++ binding site [ion binding]; other site 714962000493 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714962000494 nucleotide binding region [chemical binding]; other site 714962000495 ATP-binding site [chemical binding]; other site 714962000496 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 714962000497 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 714962000498 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 714962000499 Transglycosylase; Region: Transgly; pfam00912 714962000500 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 714962000501 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 714962000502 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 714962000503 N-terminal plug; other site 714962000504 ligand-binding site [chemical binding]; other site 714962000505 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 714962000506 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 714962000507 Walker A/P-loop; other site 714962000508 ATP binding site [chemical binding]; other site 714962000509 Q-loop/lid; other site 714962000510 ABC transporter signature motif; other site 714962000511 Walker B; other site 714962000512 D-loop; other site 714962000513 H-loop/switch region; other site 714962000514 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 714962000515 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 714962000516 siderophore binding site; other site 714962000517 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 714962000518 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714962000519 ABC-ATPase subunit interface; other site 714962000520 dimer interface [polypeptide binding]; other site 714962000521 putative PBP binding regions; other site 714962000522 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714962000523 ABC-ATPase subunit interface; other site 714962000524 dimer interface [polypeptide binding]; other site 714962000525 putative PBP binding regions; other site 714962000526 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 714962000527 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714962000528 inhibitor-cofactor binding pocket; inhibition site 714962000529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962000530 catalytic residue [active] 714962000531 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 714962000532 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 714962000533 Cl- selectivity filter; other site 714962000534 Cl- binding residues [ion binding]; other site 714962000535 pore gating glutamate residue; other site 714962000536 dimer interface [polypeptide binding]; other site 714962000537 H+/Cl- coupling transport residue; other site 714962000538 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 714962000539 hypothetical protein; Provisional; Region: PRK10578 714962000540 UPF0126 domain; Region: UPF0126; pfam03458 714962000541 UPF0126 domain; Region: UPF0126; pfam03458 714962000542 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 714962000543 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 714962000544 cobalamin binding residues [chemical binding]; other site 714962000545 putative BtuC binding residues; other site 714962000546 dimer interface [polypeptide binding]; other site 714962000547 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 714962000548 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 714962000549 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 714962000550 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714962000551 Zn2+ binding site [ion binding]; other site 714962000552 Mg2+ binding site [ion binding]; other site 714962000553 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 714962000554 serine endoprotease; Provisional; Region: PRK10942 714962000555 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 714962000556 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 714962000557 protein binding site [polypeptide binding]; other site 714962000558 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 714962000559 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 714962000560 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 714962000561 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 714962000562 hypothetical protein; Provisional; Region: PRK13677 714962000563 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 714962000564 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 714962000565 trimer interface [polypeptide binding]; other site 714962000566 active site 714962000567 substrate binding site [chemical binding]; other site 714962000568 CoA binding site [chemical binding]; other site 714962000569 PII uridylyl-transferase; Provisional; Region: PRK05007 714962000570 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 714962000571 metal binding triad; other site 714962000572 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 714962000573 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714962000574 Zn2+ binding site [ion binding]; other site 714962000575 Mg2+ binding site [ion binding]; other site 714962000576 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 714962000577 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 714962000578 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 714962000579 active site 714962000580 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 714962000581 rRNA interaction site [nucleotide binding]; other site 714962000582 S8 interaction site; other site 714962000583 putative laminin-1 binding site; other site 714962000584 elongation factor Ts; Provisional; Region: tsf; PRK09377 714962000585 UBA/TS-N domain; Region: UBA; pfam00627 714962000586 Elongation factor TS; Region: EF_TS; pfam00889 714962000587 Elongation factor TS; Region: EF_TS; pfam00889 714962000588 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 714962000589 putative nucleotide binding site [chemical binding]; other site 714962000590 uridine monophosphate binding site [chemical binding]; other site 714962000591 homohexameric interface [polypeptide binding]; other site 714962000592 ribosome recycling factor; Reviewed; Region: frr; PRK00083 714962000593 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 714962000594 hinge region; other site 714962000595 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 714962000596 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 714962000597 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 714962000598 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 714962000599 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 714962000600 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 714962000601 catalytic residue [active] 714962000602 putative FPP diphosphate binding site; other site 714962000603 putative FPP binding hydrophobic cleft; other site 714962000604 dimer interface [polypeptide binding]; other site 714962000605 putative IPP diphosphate binding site; other site 714962000606 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 714962000607 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 714962000608 zinc metallopeptidase RseP; Provisional; Region: PRK10779 714962000609 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 714962000610 active site 714962000611 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 714962000612 protein binding site [polypeptide binding]; other site 714962000613 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 714962000614 putative substrate binding region [chemical binding]; other site 714962000615 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 714962000616 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 714962000617 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 714962000618 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 714962000619 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 714962000620 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 714962000621 Surface antigen; Region: Bac_surface_Ag; pfam01103 714962000622 periplasmic chaperone; Provisional; Region: PRK10780 714962000623 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 714962000624 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 714962000625 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 714962000626 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 714962000627 trimer interface [polypeptide binding]; other site 714962000628 active site 714962000629 UDP-GlcNAc binding site [chemical binding]; other site 714962000630 lipid binding site [chemical binding]; lipid-binding site 714962000631 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 714962000632 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 714962000633 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 714962000634 active site 714962000635 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 714962000636 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 714962000637 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 714962000638 RNA/DNA hybrid binding site [nucleotide binding]; other site 714962000639 active site 714962000640 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 714962000641 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 714962000642 putative active site [active] 714962000643 putative PHP Thumb interface [polypeptide binding]; other site 714962000644 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 714962000645 generic binding surface II; other site 714962000646 generic binding surface I; other site 714962000647 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 714962000648 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 714962000649 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 714962000650 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714962000651 putative metal binding site [ion binding]; other site 714962000652 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 714962000653 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 714962000654 Ligand Binding Site [chemical binding]; other site 714962000655 TilS substrate binding domain; Region: TilS; pfam09179 714962000656 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 714962000657 Rho-binding antiterminator; Provisional; Region: PRK11625 714962000658 hypothetical protein; Provisional; Region: PRK04964 714962000659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 714962000660 hypothetical protein; Provisional; Region: PRK09256 714962000661 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 714962000662 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 714962000663 NlpE N-terminal domain; Region: NlpE; pfam04170 714962000664 hypothetical protein; Provisional; Region: PRK11479 714962000665 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 714962000666 prolyl-tRNA synthetase; Provisional; Region: PRK09194 714962000667 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 714962000668 dimer interface [polypeptide binding]; other site 714962000669 motif 1; other site 714962000670 active site 714962000671 motif 2; other site 714962000672 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 714962000673 putative deacylase active site [active] 714962000674 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 714962000675 active site 714962000676 motif 3; other site 714962000677 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 714962000678 anticodon binding site; other site 714962000679 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 714962000680 homodimer interaction site [polypeptide binding]; other site 714962000681 cofactor binding site; other site 714962000682 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 714962000683 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 714962000684 lipoprotein, YaeC family; Region: TIGR00363 714962000685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962000686 dimer interface [polypeptide binding]; other site 714962000687 conserved gate region; other site 714962000688 ABC-ATPase subunit interface; other site 714962000689 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 714962000690 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 714962000691 Walker A/P-loop; other site 714962000692 ATP binding site [chemical binding]; other site 714962000693 Q-loop/lid; other site 714962000694 ABC transporter signature motif; other site 714962000695 Walker B; other site 714962000696 D-loop; other site 714962000697 H-loop/switch region; other site 714962000698 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 714962000699 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 714962000700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962000701 active site 714962000702 motif I; other site 714962000703 motif II; other site 714962000704 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714962000705 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714962000706 active site 714962000707 catalytic tetrad [active] 714962000708 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714962000709 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962000710 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 714962000711 putative effector binding pocket; other site 714962000712 dimerization interface [polypeptide binding]; other site 714962000713 hypothetical protein; Provisional; Region: PRK05421 714962000714 putative catalytic site [active] 714962000715 putative metal binding site [ion binding]; other site 714962000716 putative phosphate binding site [ion binding]; other site 714962000717 putative catalytic site [active] 714962000718 putative phosphate binding site [ion binding]; other site 714962000719 putative metal binding site [ion binding]; other site 714962000720 Methyltransferase domain; Region: Methyltransf_31; pfam13847 714962000721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962000722 S-adenosylmethionine binding site [chemical binding]; other site 714962000723 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 714962000724 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 714962000725 N-acetyl-D-glucosamine binding site [chemical binding]; other site 714962000726 catalytic residue [active] 714962000727 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 714962000728 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 714962000729 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 714962000730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962000731 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 714962000732 RNA/DNA hybrid binding site [nucleotide binding]; other site 714962000733 active site 714962000734 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 714962000735 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 714962000736 active site 714962000737 catalytic site [active] 714962000738 substrate binding site [chemical binding]; other site 714962000739 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 714962000740 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 714962000741 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 714962000742 ImpA domain protein; Region: DUF3702; pfam12486 714962000743 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 714962000744 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 714962000745 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 714962000746 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 714962000747 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 714962000748 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 714962000749 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 714962000750 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 714962000751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962000752 Walker A motif; other site 714962000753 ATP binding site [chemical binding]; other site 714962000754 Walker B motif; other site 714962000755 arginine finger; other site 714962000756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962000757 Walker A motif; other site 714962000758 ATP binding site [chemical binding]; other site 714962000759 Walker B motif; other site 714962000760 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 714962000761 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 714962000762 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 714962000763 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 714962000764 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 714962000765 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 714962000766 FHA domain; Region: FHA; pfam00498 714962000767 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 714962000768 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 714962000769 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 714962000770 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 714962000771 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 714962000772 Protein of unknown function (DUF877); Region: DUF877; pfam05943 714962000773 Protein of unknown function (DUF770); Region: DUF770; pfam05591 714962000774 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 714962000775 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 714962000776 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 714962000777 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 714962000778 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 714962000779 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 714962000780 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 714962000781 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 714962000782 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 714962000783 putative active site [active] 714962000784 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 714962000785 C-N hydrolase family amidase; Provisional; Region: PRK10438 714962000786 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 714962000787 putative active site [active] 714962000788 catalytic triad [active] 714962000789 dimer interface [polypeptide binding]; other site 714962000790 multimer interface [polypeptide binding]; other site 714962000791 C-lysozyme inhibitor; Provisional; Region: PRK09993 714962000792 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 714962000793 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 714962000794 active site 714962000795 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 714962000796 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 714962000797 dimer interface [polypeptide binding]; other site 714962000798 active site 714962000799 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 714962000800 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 714962000801 putative active site [active] 714962000802 putative dimer interface [polypeptide binding]; other site 714962000803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 714962000804 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 714962000805 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 714962000806 NlpC/P60 family; Region: NLPC_P60; pfam00877 714962000807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 714962000808 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 714962000809 FHIPEP family; Region: FHIPEP; pfam00771 714962000810 hypothetical protein; Validated; Region: PRK06778 714962000811 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 714962000812 ligand binding site [chemical binding]; other site 714962000813 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 714962000814 active site 714962000815 DNA polymerase IV; Validated; Region: PRK02406 714962000816 DNA binding site [nucleotide binding] 714962000817 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 714962000818 putative toxin YafO; Provisional; Region: PRK09885 714962000819 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 714962000820 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714962000821 Coenzyme A binding pocket [chemical binding]; other site 714962000822 hypothetical protein; Reviewed; Region: PRK09588 714962000823 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 714962000824 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 714962000825 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 714962000826 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 714962000827 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 714962000828 metal binding site [ion binding]; metal-binding site 714962000829 dimer interface [polypeptide binding]; other site 714962000830 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714962000831 active site 714962000832 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 714962000833 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 714962000834 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 714962000835 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 714962000836 trimer interface [polypeptide binding]; other site 714962000837 eyelet of channel; other site 714962000838 gamma-glutamyl kinase; Provisional; Region: PRK05429 714962000839 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 714962000840 nucleotide binding site [chemical binding]; other site 714962000841 homotetrameric interface [polypeptide binding]; other site 714962000842 putative phosphate binding site [ion binding]; other site 714962000843 putative allosteric binding site; other site 714962000844 PUA domain; Region: PUA; pfam01472 714962000845 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 714962000846 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 714962000847 putative catalytic cysteine [active] 714962000848 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 714962000849 MarR family; Region: MarR_2; cl17246 714962000850 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 714962000851 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 714962000852 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 714962000853 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 714962000854 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 714962000855 Autotransporter beta-domain; Region: Autotransporter; pfam03797 714962000856 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 714962000857 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 714962000858 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 714962000859 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714962000860 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714962000861 DNA binding residues [nucleotide binding] 714962000862 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 714962000863 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 714962000864 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 714962000865 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 714962000866 putative active site [active] 714962000867 putative FMN binding site [chemical binding]; other site 714962000868 putative substrate binding site [chemical binding]; other site 714962000869 putative catalytic residue [active] 714962000870 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 714962000871 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714962000872 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962000873 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 714962000874 putative effector binding pocket; other site 714962000875 putative dimerization interface [polypeptide binding]; other site 714962000876 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714962000877 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962000878 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 714962000879 putative effector binding pocket; other site 714962000880 putative dimerization interface [polypeptide binding]; other site 714962000881 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714962000882 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714962000883 active site 714962000884 catalytic tetrad [active] 714962000885 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714962000886 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714962000887 active site 714962000888 catalytic tetrad [active] 714962000889 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 714962000890 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 714962000891 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 714962000892 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 714962000893 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 714962000894 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 714962000895 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962000896 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 714962000897 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714962000898 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714962000899 active site 714962000900 catalytic tetrad [active] 714962000901 Predicted membrane protein [Function unknown]; Region: COG3059 714962000902 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 714962000903 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 714962000904 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 714962000905 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714962000906 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 714962000907 Cupin; Region: Cupin_6; pfam12852 714962000908 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 714962000909 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962000910 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 714962000911 Cysteine-rich domain; Region: CCG; pfam02754 714962000912 Cysteine-rich domain; Region: CCG; pfam02754 714962000913 iron-sulfur cluster-binding protein; Region: TIGR00273 714962000914 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 714962000915 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 714962000916 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 714962000917 Uncharacterized conserved protein [Function unknown]; Region: COG1556 714962000918 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 714962000919 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 714962000920 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 714962000921 Autotransporter beta-domain; Region: Autotransporter; pfam03797 714962000922 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714962000923 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714962000924 DNA binding residues [nucleotide binding] 714962000925 dimerization interface [polypeptide binding]; other site 714962000926 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 714962000927 active site 714962000928 DNA binding site [nucleotide binding] 714962000929 Int/Topo IB signature motif; other site 714962000930 choline dehydrogenase; Validated; Region: PRK02106 714962000931 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 714962000932 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 714962000933 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 714962000934 tetrameric interface [polypeptide binding]; other site 714962000935 NAD binding site [chemical binding]; other site 714962000936 catalytic residues [active] 714962000937 transcriptional regulator BetI; Validated; Region: PRK00767 714962000938 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714962000939 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 714962000940 choline transport protein BetT; Provisional; Region: PRK09928 714962000941 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714962000942 DNA binding residues [nucleotide binding] 714962000943 dimerization interface [polypeptide binding]; other site 714962000944 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714962000945 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 714962000946 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 714962000947 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 714962000948 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 714962000949 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 714962000950 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 714962000951 CoA binding domain; Region: CoA_binding; pfam02629 714962000952 CoA-ligase; Region: Ligase_CoA; pfam00549 714962000953 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 714962000954 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 714962000955 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 714962000956 putative substrate binding site [chemical binding]; other site 714962000957 nucleotide binding site [chemical binding]; other site 714962000958 nucleotide binding site [chemical binding]; other site 714962000959 homodimer interface [polypeptide binding]; other site 714962000960 putative deaminase; Validated; Region: PRK06846 714962000961 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 714962000962 active site 714962000963 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 714962000964 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 714962000965 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 714962000966 ligand binding site [chemical binding]; other site 714962000967 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 714962000968 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 714962000969 Walker A/P-loop; other site 714962000970 ATP binding site [chemical binding]; other site 714962000971 Q-loop/lid; other site 714962000972 ABC transporter signature motif; other site 714962000973 Walker B; other site 714962000974 D-loop; other site 714962000975 H-loop/switch region; other site 714962000976 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 714962000977 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 714962000978 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 714962000979 TM-ABC transporter signature motif; other site 714962000980 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 714962000981 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 714962000982 TM-ABC transporter signature motif; other site 714962000983 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 714962000984 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 714962000985 putative NAD(P) binding site [chemical binding]; other site 714962000986 putative substrate binding site [chemical binding]; other site 714962000987 catalytic Zn binding site [ion binding]; other site 714962000988 structural Zn binding site [ion binding]; other site 714962000989 dimer interface [polypeptide binding]; other site 714962000990 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 714962000991 hypothetical protein; Provisional; Region: PRK09929 714962000992 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 714962000993 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 714962000994 tetramer interface [polypeptide binding]; other site 714962000995 active site 714962000996 Mg2+/Mn2+ binding site [ion binding]; other site 714962000997 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 714962000998 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 714962000999 dimer interface [polypeptide binding]; other site 714962001000 active site 714962001001 citrylCoA binding site [chemical binding]; other site 714962001002 oxalacetate/citrate binding site [chemical binding]; other site 714962001003 coenzyme A binding site [chemical binding]; other site 714962001004 catalytic triad [active] 714962001005 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 714962001006 2-methylcitrate dehydratase; Region: prpD; TIGR02330 714962001007 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 714962001008 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 714962001009 acyl-activating enzyme (AAE) consensus motif; other site 714962001010 putative AMP binding site [chemical binding]; other site 714962001011 putative active site [active] 714962001012 putative CoA binding site [chemical binding]; other site 714962001013 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 714962001014 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 714962001015 Na binding site [ion binding]; other site 714962001016 putative substrate binding site [chemical binding]; other site 714962001017 cytosine deaminase; Provisional; Region: PRK09230 714962001018 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 714962001019 active site 714962001020 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 714962001021 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 714962001022 active site 714962001023 substrate binding site [chemical binding]; other site 714962001024 trimer interface [polypeptide binding]; other site 714962001025 CoA binding site [chemical binding]; other site 714962001026 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 714962001027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962001028 putative substrate translocation pore; other site 714962001029 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 714962001030 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 714962001031 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 714962001032 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 714962001033 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 714962001034 lac repressor; Reviewed; Region: lacI; PRK09526 714962001035 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714962001036 DNA binding site [nucleotide binding] 714962001037 domain linker motif; other site 714962001038 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 714962001039 ligand binding site [chemical binding]; other site 714962001040 dimerization interface (open form) [polypeptide binding]; other site 714962001041 dimerization interface (closed form) [polypeptide binding]; other site 714962001042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 714962001043 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 714962001044 S-formylglutathione hydrolase; Region: PLN02442 714962001045 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 714962001046 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 714962001047 substrate binding site [chemical binding]; other site 714962001048 catalytic Zn binding site [ion binding]; other site 714962001049 NAD binding site [chemical binding]; other site 714962001050 structural Zn binding site [ion binding]; other site 714962001051 dimer interface [polypeptide binding]; other site 714962001052 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 714962001053 putative metal binding site [ion binding]; other site 714962001054 putative homodimer interface [polypeptide binding]; other site 714962001055 putative homotetramer interface [polypeptide binding]; other site 714962001056 putative homodimer-homodimer interface [polypeptide binding]; other site 714962001057 putative allosteric switch controlling residues; other site 714962001058 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 714962001059 putative trimer interface [polypeptide binding]; other site 714962001060 putative CoA binding site [chemical binding]; other site 714962001061 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 714962001062 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 714962001063 DXD motif; other site 714962001064 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 714962001065 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 714962001066 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714962001067 substrate binding pocket [chemical binding]; other site 714962001068 membrane-bound complex binding site; other site 714962001069 hinge residues; other site 714962001070 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 714962001071 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 714962001072 Walker A/P-loop; other site 714962001073 ATP binding site [chemical binding]; other site 714962001074 Q-loop/lid; other site 714962001075 ABC transporter signature motif; other site 714962001076 Walker B; other site 714962001077 D-loop; other site 714962001078 H-loop/switch region; other site 714962001079 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 714962001080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962001081 dimer interface [polypeptide binding]; other site 714962001082 conserved gate region; other site 714962001083 putative PBP binding loops; other site 714962001084 ABC-ATPase subunit interface; other site 714962001085 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 714962001086 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 714962001087 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 714962001088 dimer interface [polypeptide binding]; other site 714962001089 active site 714962001090 Schiff base residues; other site 714962001091 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 714962001092 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 714962001093 Autotransporter beta-domain; Region: Autotransporter; pfam03797 714962001094 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 714962001095 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 714962001096 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714962001097 microcin B17 transporter; Reviewed; Region: PRK11098 714962001098 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 714962001099 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 714962001100 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 714962001101 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 714962001102 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 714962001103 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 714962001104 anti-RssB factor; Provisional; Region: PRK10244 714962001105 alkaline phosphatase; Provisional; Region: PRK10518 714962001106 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 714962001107 dimer interface [polypeptide binding]; other site 714962001108 active site 714962001109 hypothetical protein; Provisional; Region: PRK11505 714962001110 psiF repeat; Region: PsiF_repeat; pfam07769 714962001111 psiF repeat; Region: PsiF_repeat; pfam07769 714962001112 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 714962001113 MASE2 domain; Region: MASE2; pfam05230 714962001114 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714962001115 metal binding site [ion binding]; metal-binding site 714962001116 active site 714962001117 I-site; other site 714962001118 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 714962001119 pyrroline-5-carboxylate reductase; Region: PLN02688 714962001120 hypothetical protein; Validated; Region: PRK00124 714962001121 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 714962001122 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 714962001123 ADP binding site [chemical binding]; other site 714962001124 magnesium binding site [ion binding]; other site 714962001125 putative shikimate binding site; other site 714962001126 hypothetical protein; Provisional; Region: PRK10380 714962001127 hypothetical protein; Provisional; Region: PRK10481 714962001128 hypothetical protein; Provisional; Region: PRK10579 714962001129 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 714962001130 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 714962001131 fructokinase; Reviewed; Region: PRK09557 714962001132 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 714962001133 nucleotide binding site [chemical binding]; other site 714962001134 MFS transport protein AraJ; Provisional; Region: PRK10091 714962001135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962001136 putative substrate translocation pore; other site 714962001137 exonuclease subunit SbcC; Provisional; Region: PRK10246 714962001138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962001139 Walker A/P-loop; other site 714962001140 ATP binding site [chemical binding]; other site 714962001141 Q-loop/lid; other site 714962001142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962001143 ABC transporter signature motif; other site 714962001144 Walker B; other site 714962001145 D-loop; other site 714962001146 H-loop/switch region; other site 714962001147 exonuclease subunit SbcD; Provisional; Region: PRK10966 714962001148 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 714962001149 active site 714962001150 metal binding site [ion binding]; metal-binding site 714962001151 DNA binding site [nucleotide binding] 714962001152 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 714962001153 transcriptional regulator PhoB; Provisional; Region: PRK10161 714962001154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962001155 active site 714962001156 phosphorylation site [posttranslational modification] 714962001157 intermolecular recognition site; other site 714962001158 dimerization interface [polypeptide binding]; other site 714962001159 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714962001160 DNA binding site [nucleotide binding] 714962001161 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 714962001162 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 714962001163 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714962001164 putative active site [active] 714962001165 heme pocket [chemical binding]; other site 714962001166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962001167 dimer interface [polypeptide binding]; other site 714962001168 phosphorylation site [posttranslational modification] 714962001169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962001170 ATP binding site [chemical binding]; other site 714962001171 Mg2+ binding site [ion binding]; other site 714962001172 G-X-G motif; other site 714962001173 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 714962001174 putative proline-specific permease; Provisional; Region: proY; PRK10580 714962001175 Spore germination protein; Region: Spore_permease; cl17796 714962001176 maltodextrin glucosidase; Provisional; Region: PRK10785 714962001177 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 714962001178 homodimer interface [polypeptide binding]; other site 714962001179 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 714962001180 active site 714962001181 homodimer interface [polypeptide binding]; other site 714962001182 catalytic site [active] 714962001183 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 714962001184 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 714962001185 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 714962001186 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 714962001187 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 714962001188 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 714962001189 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 714962001190 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 714962001191 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 714962001192 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 714962001193 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 714962001194 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 714962001195 Protein export membrane protein; Region: SecD_SecF; pfam02355 714962001196 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 714962001197 active site 714962001198 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 714962001199 hypothetical protein; Provisional; Region: PRK11530 714962001200 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 714962001201 ATP cone domain; Region: ATP-cone; pfam03477 714962001202 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 714962001203 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 714962001204 catalytic motif [active] 714962001205 Zn binding site [ion binding]; other site 714962001206 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 714962001207 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 714962001208 homopentamer interface [polypeptide binding]; other site 714962001209 active site 714962001210 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 714962001211 putative RNA binding site [nucleotide binding]; other site 714962001212 thiamine monophosphate kinase; Provisional; Region: PRK05731 714962001213 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 714962001214 ATP binding site [chemical binding]; other site 714962001215 dimerization interface [polypeptide binding]; other site 714962001216 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 714962001217 tetramer interfaces [polypeptide binding]; other site 714962001218 binuclear metal-binding site [ion binding]; other site 714962001219 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714962001220 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714962001221 active site 714962001222 catalytic tetrad [active] 714962001223 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 714962001224 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 714962001225 TPP-binding site; other site 714962001226 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 714962001227 PYR/PP interface [polypeptide binding]; other site 714962001228 dimer interface [polypeptide binding]; other site 714962001229 TPP binding site [chemical binding]; other site 714962001230 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 714962001231 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 714962001232 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 714962001233 substrate binding pocket [chemical binding]; other site 714962001234 chain length determination region; other site 714962001235 substrate-Mg2+ binding site; other site 714962001236 catalytic residues [active] 714962001237 aspartate-rich region 1; other site 714962001238 active site lid residues [active] 714962001239 aspartate-rich region 2; other site 714962001240 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 714962001241 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 714962001242 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 714962001243 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 714962001244 Ligand Binding Site [chemical binding]; other site 714962001245 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 714962001246 active site residue [active] 714962001247 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 714962001248 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 714962001249 conserved cys residue [active] 714962001250 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 714962001251 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 714962001252 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 714962001253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 714962001254 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 714962001255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962001256 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714962001257 putative substrate translocation pore; other site 714962001258 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 714962001259 UbiA prenyltransferase family; Region: UbiA; pfam01040 714962001260 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 714962001261 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 714962001262 Subunit I/III interface [polypeptide binding]; other site 714962001263 Subunit III/IV interface [polypeptide binding]; other site 714962001264 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 714962001265 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 714962001266 D-pathway; other site 714962001267 Putative ubiquinol binding site [chemical binding]; other site 714962001268 Low-spin heme (heme b) binding site [chemical binding]; other site 714962001269 Putative water exit pathway; other site 714962001270 Binuclear center (heme o3/CuB) [ion binding]; other site 714962001271 K-pathway; other site 714962001272 Putative proton exit pathway; other site 714962001273 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 714962001274 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 714962001275 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 714962001276 muropeptide transporter; Reviewed; Region: ampG; PRK11902 714962001277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962001278 putative substrate translocation pore; other site 714962001279 hypothetical protein; Provisional; Region: PRK11627 714962001280 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 714962001281 transcriptional regulator BolA; Provisional; Region: PRK11628 714962001282 trigger factor; Provisional; Region: tig; PRK01490 714962001283 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 714962001284 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 714962001285 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 714962001286 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 714962001287 oligomer interface [polypeptide binding]; other site 714962001288 active site residues [active] 714962001289 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 714962001290 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 714962001291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962001292 Walker A motif; other site 714962001293 ATP binding site [chemical binding]; other site 714962001294 Walker B motif; other site 714962001295 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 714962001296 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 714962001297 Found in ATP-dependent protease La (LON); Region: LON; smart00464 714962001298 Found in ATP-dependent protease La (LON); Region: LON; smart00464 714962001299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962001300 Walker A motif; other site 714962001301 ATP binding site [chemical binding]; other site 714962001302 Walker B motif; other site 714962001303 arginine finger; other site 714962001304 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 714962001305 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 714962001306 IHF dimer interface [polypeptide binding]; other site 714962001307 IHF - DNA interface [nucleotide binding]; other site 714962001308 periplasmic folding chaperone; Provisional; Region: PRK10788 714962001309 SurA N-terminal domain; Region: SurA_N_3; cl07813 714962001310 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 714962001311 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 714962001312 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 714962001313 active site 714962001314 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 714962001315 Ligand Binding Site [chemical binding]; other site 714962001316 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 714962001317 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 714962001318 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 714962001319 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 714962001320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962001321 active site 714962001322 motif I; other site 714962001323 motif II; other site 714962001324 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 714962001325 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714962001326 putative DNA binding site [nucleotide binding]; other site 714962001327 putative Zn2+ binding site [ion binding]; other site 714962001328 AsnC family; Region: AsnC_trans_reg; pfam01037 714962001329 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714962001330 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 714962001331 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962001332 Walker A/P-loop; other site 714962001333 ATP binding site [chemical binding]; other site 714962001334 Q-loop/lid; other site 714962001335 ABC transporter signature motif; other site 714962001336 Walker B; other site 714962001337 D-loop; other site 714962001338 H-loop/switch region; other site 714962001339 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 714962001340 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714962001341 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 714962001342 Walker A/P-loop; other site 714962001343 ATP binding site [chemical binding]; other site 714962001344 Q-loop/lid; other site 714962001345 ABC transporter signature motif; other site 714962001346 Walker B; other site 714962001347 D-loop; other site 714962001348 H-loop/switch region; other site 714962001349 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 714962001350 Nitrogen regulatory protein P-II; Region: P-II; smart00938 714962001351 ammonium transporter; Provisional; Region: PRK10666 714962001352 acyl-CoA thioesterase II; Provisional; Region: PRK10526 714962001353 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 714962001354 active site 714962001355 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 714962001356 catalytic triad [active] 714962001357 dimer interface [polypeptide binding]; other site 714962001358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 714962001359 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 714962001360 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 714962001361 DNA binding site [nucleotide binding] 714962001362 active site 714962001363 Uncharacterized conserved protein [Function unknown]; Region: COG5507 714962001364 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 714962001365 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 714962001366 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714962001367 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 714962001368 maltose O-acetyltransferase; Provisional; Region: PRK10092 714962001369 Maltose acetyltransferase; Region: Mac; pfam12464 714962001370 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 714962001371 trimer interface [polypeptide binding]; other site 714962001372 active site 714962001373 substrate binding site [chemical binding]; other site 714962001374 CoA binding site [chemical binding]; other site 714962001375 gene expression modulator; Provisional; Region: PRK10945 714962001376 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 714962001377 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 714962001378 Protein export membrane protein; Region: SecD_SecF; cl14618 714962001379 Protein export membrane protein; Region: SecD_SecF; cl14618 714962001380 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 714962001381 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 714962001382 HlyD family secretion protein; Region: HlyD_3; pfam13437 714962001383 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 714962001384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714962001385 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 714962001386 hypothetical protein; Provisional; Region: PRK11281 714962001387 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 714962001388 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 714962001389 Mechanosensitive ion channel; Region: MS_channel; pfam00924 714962001390 hypothetical protein; Provisional; Region: PRK11038 714962001391 primosomal replication protein N''; Provisional; Region: PRK10093 714962001392 hypothetical protein; Provisional; Region: PRK10527 714962001393 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714962001394 active site 714962001395 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 714962001396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962001397 Walker A motif; other site 714962001398 ATP binding site [chemical binding]; other site 714962001399 Walker B motif; other site 714962001400 DNA polymerase III subunit delta'; Validated; Region: PRK08485 714962001401 arginine finger; other site 714962001402 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 714962001403 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 714962001404 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 714962001405 hypothetical protein; Validated; Region: PRK00153 714962001406 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 714962001407 RecR protein; Region: RecR; pfam02132 714962001408 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 714962001409 putative active site [active] 714962001410 putative metal-binding site [ion binding]; other site 714962001411 tetramer interface [polypeptide binding]; other site 714962001412 heat shock protein 90; Provisional; Region: PRK05218 714962001413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962001414 ATP binding site [chemical binding]; other site 714962001415 Mg2+ binding site [ion binding]; other site 714962001416 G-X-G motif; other site 714962001417 adenylate kinase; Reviewed; Region: adk; PRK00279 714962001418 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 714962001419 AMP-binding site [chemical binding]; other site 714962001420 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 714962001421 ferrochelatase; Region: hemH; TIGR00109 714962001422 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 714962001423 C-terminal domain interface [polypeptide binding]; other site 714962001424 active site 714962001425 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 714962001426 active site 714962001427 N-terminal domain interface [polypeptide binding]; other site 714962001428 acetyl esterase; Provisional; Region: PRK10162 714962001429 inosine/guanosine kinase; Provisional; Region: PRK15074 714962001430 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 714962001431 putative cation:proton antiport protein; Provisional; Region: PRK10669 714962001432 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 714962001433 TrkA-N domain; Region: TrkA_N; pfam02254 714962001434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962001435 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714962001436 putative substrate translocation pore; other site 714962001437 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 714962001438 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 714962001439 active site 714962001440 metal binding site [ion binding]; metal-binding site 714962001441 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 714962001442 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 714962001443 putative deacylase active site [active] 714962001444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 714962001445 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 714962001446 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714962001447 non-specific DNA binding site [nucleotide binding]; other site 714962001448 salt bridge; other site 714962001449 sequence-specific DNA binding site [nucleotide binding]; other site 714962001450 copper exporting ATPase; Provisional; Region: copA; PRK10671 714962001451 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 714962001452 metal-binding site [ion binding] 714962001453 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 714962001454 metal-binding site [ion binding] 714962001455 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714962001456 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962001457 motif II; other site 714962001458 glutaminase; Reviewed; Region: PRK12356 714962001459 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 714962001460 amino acid transporter; Region: 2A0306; TIGR00909 714962001461 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 714962001462 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 714962001463 DNA binding residues [nucleotide binding] 714962001464 dimer interface [polypeptide binding]; other site 714962001465 copper binding site [ion binding]; other site 714962001466 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 714962001467 YadA-like C-terminal region; Region: YadA; pfam03895 714962001468 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 714962001469 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 714962001470 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 714962001471 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 714962001472 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962001473 Walker A/P-loop; other site 714962001474 ATP binding site [chemical binding]; other site 714962001475 Q-loop/lid; other site 714962001476 ABC transporter signature motif; other site 714962001477 Walker B; other site 714962001478 D-loop; other site 714962001479 H-loop/switch region; other site 714962001480 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 714962001481 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 714962001482 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 714962001483 oxidoreductase; Provisional; Region: PRK08017 714962001484 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 714962001485 NADP binding site [chemical binding]; other site 714962001486 active site 714962001487 steroid binding site; other site 714962001488 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 714962001489 active site 714962001490 catalytic triad [active] 714962001491 oxyanion hole [active] 714962001492 switch loop; other site 714962001493 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 714962001494 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 714962001495 Walker A/P-loop; other site 714962001496 ATP binding site [chemical binding]; other site 714962001497 Q-loop/lid; other site 714962001498 ABC transporter signature motif; other site 714962001499 Walker B; other site 714962001500 D-loop; other site 714962001501 H-loop/switch region; other site 714962001502 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 714962001503 FtsX-like permease family; Region: FtsX; pfam02687 714962001504 FtsX-like permease family; Region: FtsX; pfam02687 714962001505 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 714962001506 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 714962001507 active site residue [active] 714962001508 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 714962001509 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962001510 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714962001511 dimerization interface [polypeptide binding]; other site 714962001512 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 714962001513 ureidoglycolate hydrolase; Provisional; Region: PRK03606 714962001514 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 714962001515 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 714962001516 Bacterial transcriptional regulator; Region: IclR; pfam01614 714962001517 glyoxylate carboligase; Provisional; Region: PRK11269 714962001518 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 714962001519 PYR/PP interface [polypeptide binding]; other site 714962001520 dimer interface [polypeptide binding]; other site 714962001521 TPP binding site [chemical binding]; other site 714962001522 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 714962001523 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 714962001524 TPP-binding site [chemical binding]; other site 714962001525 hydroxypyruvate isomerase; Provisional; Region: PRK09997 714962001526 tartronate semialdehyde reductase; Provisional; Region: PRK15059 714962001527 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 714962001528 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 714962001529 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 714962001530 Na binding site [ion binding]; other site 714962001531 substrate binding site [chemical binding]; other site 714962001532 allantoinase; Provisional; Region: PRK08044 714962001533 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 714962001534 active site 714962001535 putative uracil/xanthine transporter; Provisional; Region: PRK11412 714962001536 glycerate kinase II; Provisional; Region: PRK09932 714962001537 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 714962001538 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 714962001539 Cupin domain; Region: Cupin_2; cl17218 714962001540 allantoate amidohydrolase; Region: AllC; TIGR03176 714962001541 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 714962001542 active site 714962001543 metal binding site [ion binding]; metal-binding site 714962001544 dimer interface [polypeptide binding]; other site 714962001545 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 714962001546 membrane protein FdrA; Validated; Region: PRK06091 714962001547 CoA binding domain; Region: CoA_binding; pfam02629 714962001548 CoA-ligase; Region: Ligase_CoA; pfam00549 714962001549 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 714962001550 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 714962001551 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 714962001552 putative substrate binding site [chemical binding]; other site 714962001553 nucleotide binding site [chemical binding]; other site 714962001554 nucleotide binding site [chemical binding]; other site 714962001555 homodimer interface [polypeptide binding]; other site 714962001556 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 714962001557 ATP-grasp domain; Region: ATP-grasp; pfam02222 714962001558 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 714962001559 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 714962001560 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714962001561 putative active site [active] 714962001562 putative metal binding site [ion binding]; other site 714962001563 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 714962001564 substrate binding site [chemical binding]; other site 714962001565 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 714962001566 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 714962001567 active site 714962001568 HIGH motif; other site 714962001569 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 714962001570 KMSKS motif; other site 714962001571 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 714962001572 tRNA binding surface [nucleotide binding]; other site 714962001573 anticodon binding site; other site 714962001574 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 714962001575 ribosome-associated protein; Provisional; Region: PRK11507 714962001576 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 714962001577 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 714962001578 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 714962001579 homodimer interface [polypeptide binding]; other site 714962001580 NADP binding site [chemical binding]; other site 714962001581 substrate binding site [chemical binding]; other site 714962001582 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 714962001583 Int/Topo IB signature motif; other site 714962001584 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 714962001585 Uncharacterized conserved protein [Function unknown]; Region: COG5532 714962001586 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 714962001587 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 714962001588 P-loop; other site 714962001589 Magnesium ion binding site [ion binding]; other site 714962001590 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 714962001591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714962001592 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 714962001593 non-specific DNA binding site [nucleotide binding]; other site 714962001594 salt bridge; other site 714962001595 sequence-specific DNA binding site [nucleotide binding]; other site 714962001596 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 714962001597 Catalytic site [active] 714962001598 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962001599 DNA-binding site [nucleotide binding]; DNA binding site 714962001600 PerC transcriptional activator; Region: PerC; pfam06069 714962001601 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 714962001602 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 714962001603 KilA-N domain; Region: KilA-N; pfam04383 714962001604 Protein of unknown function (DUF968); Region: DUF968; pfam06147 714962001605 Antitermination protein; Region: Antiterm; pfam03589 714962001606 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 714962001607 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 714962001608 Zn binding sites [ion binding]; other site 714962001609 Antitermination protein; Region: Antiterm; pfam03589 714962001610 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 714962001611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962001612 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 714962001613 DNA methylase; Region: N6_N4_Mtase; pfam01555 714962001614 Lysis protein S; Region: Lysis_S; pfam04971 714962001615 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 714962001616 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 714962001617 catalytic residues [active] 714962001618 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 714962001619 Bor protein; Region: Lambda_Bor; pfam06291 714962001620 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 714962001621 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 714962001622 gpW; Region: gpW; pfam02831 714962001623 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 714962001624 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 714962001625 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 714962001626 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 714962001627 tandem repeat interface [polypeptide binding]; other site 714962001628 oligomer interface [polypeptide binding]; other site 714962001629 active site residues [active] 714962001630 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 714962001631 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 714962001632 DNA packaging protein FI; Region: Packaging_FI; pfam14000 714962001633 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 714962001634 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 714962001635 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 714962001636 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 714962001637 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 714962001638 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 714962001639 Minor tail protein T; Region: Phage_tail_T; pfam06223 714962001640 Phage-related minor tail protein [Function unknown]; Region: COG5281 714962001641 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 714962001642 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 714962001643 Phage-related protein [Function unknown]; Region: COG4718 714962001644 Phage-related protein [Function unknown]; Region: gp18; COG4672 714962001645 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 714962001646 MPN+ (JAMM) motif; other site 714962001647 Zinc-binding site [ion binding]; other site 714962001648 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 714962001649 NlpC/P60 family; Region: NLPC_P60; cl17555 714962001650 Phage-related protein, tail component [Function unknown]; Region: COG4723 714962001651 Phage-related protein, tail component [Function unknown]; Region: COG4733 714962001652 Putative phage tail protein; Region: Phage-tail_3; pfam13550 714962001653 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 714962001654 Fibronectin type III protein; Region: DUF3672; pfam12421 714962001655 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 714962001656 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 714962001657 Methyltransferase domain; Region: Methyltransf_31; pfam13847 714962001658 Methyltransferase domain; Region: Methyltransf_12; pfam08242 714962001659 S-adenosylmethionine binding site [chemical binding]; other site 714962001660 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 714962001661 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 714962001662 TAP-like protein; Region: Abhydrolase_4; pfam08386 714962001663 outer membrane protease; Reviewed; Region: PRK10993 714962001664 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 714962001665 Methyltransferase domain; Region: Methyltransf_12; pfam08242 714962001666 S-adenosylmethionine binding site [chemical binding]; other site 714962001667 outer membrane protease; Reviewed; Region: PRK10993 714962001668 hypothetical protein; Provisional; Region: PRK09936 714962001669 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 714962001670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714962001671 TPR motif; other site 714962001672 binding surface 714962001673 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 714962001674 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 714962001675 active site 714962001676 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 714962001677 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 714962001678 sensor kinase CusS; Provisional; Region: PRK09835 714962001679 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714962001680 dimerization interface [polypeptide binding]; other site 714962001681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962001682 dimer interface [polypeptide binding]; other site 714962001683 phosphorylation site [posttranslational modification] 714962001684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962001685 ATP binding site [chemical binding]; other site 714962001686 Mg2+ binding site [ion binding]; other site 714962001687 G-X-G motif; other site 714962001688 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 714962001689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962001690 active site 714962001691 phosphorylation site [posttranslational modification] 714962001692 intermolecular recognition site; other site 714962001693 dimerization interface [polypeptide binding]; other site 714962001694 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714962001695 DNA binding site [nucleotide binding] 714962001696 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 714962001697 periplasmic copper-binding protein; Provisional; Region: PRK09838 714962001698 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 714962001699 HlyD family secretion protein; Region: HlyD_3; pfam13437 714962001700 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 714962001701 phenylalanine transporter; Provisional; Region: PRK10249 714962001702 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 714962001703 Mechanosensitive ion channel; Region: MS_channel; pfam00924 714962001704 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 714962001705 dimer interface [polypeptide binding]; other site 714962001706 FMN binding site [chemical binding]; other site 714962001707 hypothetical protein; Provisional; Region: PRK10250 714962001708 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 714962001709 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 714962001710 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 714962001711 Hok/gef family; Region: HOK_GEF; pfam01848 714962001712 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 714962001713 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 714962001714 outer membrane receptor FepA; Provisional; Region: PRK13524 714962001715 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 714962001716 N-terminal plug; other site 714962001717 ligand-binding site [chemical binding]; other site 714962001718 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 714962001719 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 714962001720 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 714962001721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 714962001722 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 714962001723 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 714962001724 acyl-activating enzyme (AAE) consensus motif; other site 714962001725 AMP binding site [chemical binding]; other site 714962001726 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714962001727 LPS O-antigen length regulator; Provisional; Region: PRK10381 714962001728 Chain length determinant protein; Region: Wzz; pfam02706 714962001729 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 714962001730 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 714962001731 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 714962001732 Walker A/P-loop; other site 714962001733 ATP binding site [chemical binding]; other site 714962001734 Q-loop/lid; other site 714962001735 ABC transporter signature motif; other site 714962001736 Walker B; other site 714962001737 D-loop; other site 714962001738 H-loop/switch region; other site 714962001739 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 714962001740 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714962001741 ABC-ATPase subunit interface; other site 714962001742 dimer interface [polypeptide binding]; other site 714962001743 putative PBP binding regions; other site 714962001744 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 714962001745 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714962001746 ABC-ATPase subunit interface; other site 714962001747 dimer interface [polypeptide binding]; other site 714962001748 putative PBP binding regions; other site 714962001749 enterobactin exporter EntS; Provisional; Region: PRK10489 714962001750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962001751 putative substrate translocation pore; other site 714962001752 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 714962001753 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 714962001754 siderophore binding site; other site 714962001755 isochorismate synthase EntC; Provisional; Region: PRK15016 714962001756 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 714962001757 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 714962001758 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 714962001759 acyl-activating enzyme (AAE) consensus motif; other site 714962001760 active site 714962001761 AMP binding site [chemical binding]; other site 714962001762 substrate binding site [chemical binding]; other site 714962001763 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 714962001764 hydrophobic substrate binding pocket; other site 714962001765 Isochorismatase family; Region: Isochorismatase; pfam00857 714962001766 active site 714962001767 conserved cis-peptide bond; other site 714962001768 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 714962001769 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 714962001770 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 714962001771 putative NAD(P) binding site [chemical binding]; other site 714962001772 active site 714962001773 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 714962001774 CoenzymeA binding site [chemical binding]; other site 714962001775 subunit interaction site [polypeptide binding]; other site 714962001776 PHB binding site; other site 714962001777 carbon starvation protein A; Provisional; Region: PRK15015 714962001778 Carbon starvation protein CstA; Region: CstA; pfam02554 714962001779 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 714962001780 Uncharacterized small protein [Function unknown]; Region: COG2879 714962001781 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 714962001782 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 714962001783 putative active site [active] 714962001784 metal binding site [ion binding]; metal-binding site 714962001785 methionine aminotransferase; Validated; Region: PRK09082 714962001786 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714962001787 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962001788 homodimer interface [polypeptide binding]; other site 714962001789 catalytic residue [active] 714962001790 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 714962001791 ParB-like nuclease domain; Region: ParBc; pfam02195 714962001792 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 714962001793 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 714962001794 Active Sites [active] 714962001795 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 714962001796 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 714962001797 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962001798 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714962001799 dimerization interface [polypeptide binding]; other site 714962001800 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 714962001801 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 714962001802 dimerization domain [polypeptide binding]; other site 714962001803 dimer interface [polypeptide binding]; other site 714962001804 catalytic residues [active] 714962001805 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 714962001806 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 714962001807 dimer interface [polypeptide binding]; other site 714962001808 decamer (pentamer of dimers) interface [polypeptide binding]; other site 714962001809 catalytic triad [active] 714962001810 peroxidatic and resolving cysteines [active] 714962001811 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 714962001812 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 714962001813 catalytic residue [active] 714962001814 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 714962001815 catalytic residues [active] 714962001816 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714962001817 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714962001818 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 714962001819 Ligand Binding Site [chemical binding]; other site 714962001820 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 714962001821 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 714962001822 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 714962001823 B1 nucleotide binding pocket [chemical binding]; other site 714962001824 B2 nucleotide binding pocket [chemical binding]; other site 714962001825 CAS motifs; other site 714962001826 active site 714962001827 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 714962001828 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 714962001829 transmembrane helices; other site 714962001830 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 714962001831 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 714962001832 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 714962001833 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 714962001834 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 714962001835 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 714962001836 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 714962001837 putative active site [active] 714962001838 (T/H)XGH motif; other site 714962001839 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 714962001840 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714962001841 putative active site [active] 714962001842 heme pocket [chemical binding]; other site 714962001843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962001844 ATP binding site [chemical binding]; other site 714962001845 Mg2+ binding site [ion binding]; other site 714962001846 G-X-G motif; other site 714962001847 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 714962001848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962001849 active site 714962001850 phosphorylation site [posttranslational modification] 714962001851 intermolecular recognition site; other site 714962001852 dimerization interface [polypeptide binding]; other site 714962001853 Transcriptional regulator; Region: CitT; pfam12431 714962001854 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 714962001855 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 714962001856 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 714962001857 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 714962001858 DNA-binding site [nucleotide binding]; DNA binding site 714962001859 RNA-binding motif; other site 714962001860 chromosome condensation membrane protein; Provisional; Region: PRK14196 714962001861 Predicted amidohydrolase [General function prediction only]; Region: COG0388 714962001862 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 714962001863 putative active site [active] 714962001864 catalytic triad [active] 714962001865 putative dimer interface [polypeptide binding]; other site 714962001866 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 714962001867 lipoyl synthase; Provisional; Region: PRK05481 714962001868 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714962001869 FeS/SAM binding site; other site 714962001870 lipoate-protein ligase B; Provisional; Region: PRK14342 714962001871 hypothetical protein; Provisional; Region: PRK04998 714962001872 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 714962001873 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 714962001874 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 714962001875 rare lipoprotein A; Provisional; Region: PRK10672 714962001876 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 714962001877 Sporulation related domain; Region: SPOR; pfam05036 714962001878 cell wall shape-determining protein; Provisional; Region: PRK10794 714962001879 penicillin-binding protein 2; Provisional; Region: PRK10795 714962001880 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714962001881 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 714962001882 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 714962001883 ribosome-associated protein; Provisional; Region: PRK11538 714962001884 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714962001885 catalytic core [active] 714962001886 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 714962001887 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 714962001888 active site 714962001889 (T/H)XGH motif; other site 714962001890 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 714962001891 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 714962001892 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 714962001893 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 714962001894 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 714962001895 HIGH motif; other site 714962001896 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 714962001897 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 714962001898 active site 714962001899 KMSKS motif; other site 714962001900 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 714962001901 tRNA binding surface [nucleotide binding]; other site 714962001902 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 714962001903 hypothetical protein; Provisional; Region: PRK11032 714962001904 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 714962001905 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 714962001906 active site 714962001907 tetramer interface [polypeptide binding]; other site 714962001908 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 714962001909 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 714962001910 Walker A/P-loop; other site 714962001911 ATP binding site [chemical binding]; other site 714962001912 Q-loop/lid; other site 714962001913 ABC transporter signature motif; other site 714962001914 Walker B; other site 714962001915 D-loop; other site 714962001916 H-loop/switch region; other site 714962001917 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 714962001918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962001919 dimer interface [polypeptide binding]; other site 714962001920 conserved gate region; other site 714962001921 putative PBP binding loops; other site 714962001922 ABC-ATPase subunit interface; other site 714962001923 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 714962001924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962001925 dimer interface [polypeptide binding]; other site 714962001926 conserved gate region; other site 714962001927 putative PBP binding loops; other site 714962001928 ABC-ATPase subunit interface; other site 714962001929 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 714962001930 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714962001931 substrate binding pocket [chemical binding]; other site 714962001932 membrane-bound complex binding site; other site 714962001933 hinge residues; other site 714962001934 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 714962001935 Uncharacterized conserved protein [Function unknown]; Region: COG3391 714962001936 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 714962001937 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 714962001938 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 714962001939 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 714962001940 putative active site [active] 714962001941 catalytic triad [active] 714962001942 putative dimer interface [polypeptide binding]; other site 714962001943 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 714962001944 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 714962001945 Transporter associated domain; Region: CorC_HlyC; smart01091 714962001946 metal-binding heat shock protein; Provisional; Region: PRK00016 714962001947 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 714962001948 PhoH-like protein; Region: PhoH; pfam02562 714962001949 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 714962001950 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 714962001951 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714962001952 FeS/SAM binding site; other site 714962001953 TRAM domain; Region: TRAM; pfam01938 714962001954 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 714962001955 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 714962001956 asparagine synthetase B; Provisional; Region: asnB; PRK09431 714962001957 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 714962001958 active site 714962001959 dimer interface [polypeptide binding]; other site 714962001960 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 714962001961 Ligand Binding Site [chemical binding]; other site 714962001962 Molecular Tunnel; other site 714962001963 UMP phosphatase; Provisional; Region: PRK10444 714962001964 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962001965 active site 714962001966 motif I; other site 714962001967 motif II; other site 714962001968 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962001969 MarR family; Region: MarR; pfam01047 714962001970 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 714962001971 ROK family; Region: ROK; pfam00480 714962001972 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 714962001973 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 714962001974 active site 714962001975 dimer interface [polypeptide binding]; other site 714962001976 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 714962001977 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 714962001978 active site 714962001979 trimer interface [polypeptide binding]; other site 714962001980 allosteric site; other site 714962001981 active site lid [active] 714962001982 hexamer (dimer of trimers) interface [polypeptide binding]; other site 714962001983 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 714962001984 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 714962001985 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714962001986 active site turn [active] 714962001987 phosphorylation site [posttranslational modification] 714962001988 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 714962001989 HPr interaction site; other site 714962001990 glycerol kinase (GK) interaction site [polypeptide binding]; other site 714962001991 active site 714962001992 phosphorylation site [posttranslational modification] 714962001993 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 714962001994 transmembrane helices; other site 714962001995 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 714962001996 Domain of unknown function (DUF386); Region: DUF386; cl01047 714962001997 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 714962001998 BNR repeat-like domain; Region: BNR_2; pfam13088 714962001999 dihydrodipicolinate synthase; Region: dapA; TIGR00674 714962002000 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 714962002001 inhibitor site; inhibition site 714962002002 active site 714962002003 dimer interface [polypeptide binding]; other site 714962002004 catalytic residue [active] 714962002005 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 714962002006 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 714962002007 putative active site [active] 714962002008 metal binding site [ion binding]; metal-binding site 714962002009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 714962002010 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 714962002011 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 714962002012 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 714962002013 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 714962002014 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 714962002015 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 714962002016 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 714962002017 active site 714962002018 HIGH motif; other site 714962002019 nucleotide binding site [chemical binding]; other site 714962002020 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 714962002021 KMSKS motif; other site 714962002022 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 714962002023 YbfN-like lipoprotein; Region: YbfN; pfam13982 714962002024 ferric uptake regulator; Provisional; Region: fur; PRK09462 714962002025 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 714962002026 metal binding site 2 [ion binding]; metal-binding site 714962002027 putative DNA binding helix; other site 714962002028 metal binding site 1 [ion binding]; metal-binding site 714962002029 dimer interface [polypeptide binding]; other site 714962002030 structural Zn2+ binding site [ion binding]; other site 714962002031 flavodoxin FldA; Validated; Region: PRK09267 714962002032 LexA regulated protein; Provisional; Region: PRK11675 714962002033 acyl-CoA esterase; Provisional; Region: PRK10673 714962002034 PGAP1-like protein; Region: PGAP1; pfam07819 714962002035 replication initiation regulator SeqA; Provisional; Region: PRK11187 714962002036 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 714962002037 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 714962002038 active site 714962002039 substrate binding site [chemical binding]; other site 714962002040 metal binding site [ion binding]; metal-binding site 714962002041 putrescine transporter; Provisional; Region: potE; PRK10655 714962002042 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 714962002043 ornithine decarboxylase; Provisional; Region: PRK13578 714962002044 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 714962002045 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 714962002046 homodimer interface [polypeptide binding]; other site 714962002047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962002048 catalytic residue [active] 714962002049 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 714962002050 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 714962002051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962002052 active site 714962002053 phosphorylation site [posttranslational modification] 714962002054 intermolecular recognition site; other site 714962002055 dimerization interface [polypeptide binding]; other site 714962002056 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714962002057 DNA binding site [nucleotide binding] 714962002058 sensor protein KdpD; Provisional; Region: PRK10490 714962002059 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 714962002060 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 714962002061 Ligand Binding Site [chemical binding]; other site 714962002062 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 714962002063 GAF domain; Region: GAF_3; pfam13492 714962002064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962002065 dimer interface [polypeptide binding]; other site 714962002066 phosphorylation site [posttranslational modification] 714962002067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962002068 ATP binding site [chemical binding]; other site 714962002069 Mg2+ binding site [ion binding]; other site 714962002070 G-X-G motif; other site 714962002071 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 714962002072 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 714962002073 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714962002074 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 714962002075 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 714962002076 hypothetical protein; Provisional; Region: PRK10167 714962002077 Uncharacterized conserved protein [Function unknown]; Region: COG3272 714962002078 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 714962002079 DNA photolyase; Region: DNA_photolyase; pfam00875 714962002080 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 714962002081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962002082 putative substrate translocation pore; other site 714962002083 POT family; Region: PTR2; pfam00854 714962002084 Uncharacterized conserved protein [Function unknown]; Region: COG0327 714962002085 metal-binding protein; Provisional; Region: PRK10799 714962002086 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 714962002087 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 714962002088 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 714962002089 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 714962002090 putative active site [active] 714962002091 endonuclease VIII; Provisional; Region: PRK10445 714962002092 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 714962002093 DNA binding site [nucleotide binding] 714962002094 catalytic residue [active] 714962002095 putative catalytic residues [active] 714962002096 H2TH interface [polypeptide binding]; other site 714962002097 intercalation triad [nucleotide binding]; other site 714962002098 substrate specificity determining residue; other site 714962002099 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 714962002100 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 714962002101 Putative ammonia monooxygenase; Region: AmoA; pfam05145 714962002102 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 714962002103 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 714962002104 Fimbrial protein; Region: Fimbrial; pfam00419 714962002105 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 714962002106 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 714962002107 dimer interface [polypeptide binding]; other site 714962002108 active site 714962002109 citrylCoA binding site [chemical binding]; other site 714962002110 NADH binding [chemical binding]; other site 714962002111 cationic pore residues; other site 714962002112 oxalacetate/citrate binding site [chemical binding]; other site 714962002113 coenzyme A binding site [chemical binding]; other site 714962002114 catalytic triad [active] 714962002115 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 714962002116 Iron-sulfur protein interface; other site 714962002117 proximal quinone binding site [chemical binding]; other site 714962002118 SdhD (CybS) interface [polypeptide binding]; other site 714962002119 proximal heme binding site [chemical binding]; other site 714962002120 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 714962002121 SdhC subunit interface [polypeptide binding]; other site 714962002122 proximal heme binding site [chemical binding]; other site 714962002123 cardiolipin binding site; other site 714962002124 Iron-sulfur protein interface; other site 714962002125 proximal quinone binding site [chemical binding]; other site 714962002126 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 714962002127 L-aspartate oxidase; Provisional; Region: PRK06175 714962002128 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 714962002129 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 714962002130 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 714962002131 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 714962002132 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 714962002133 TPP-binding site [chemical binding]; other site 714962002134 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 714962002135 dimer interface [polypeptide binding]; other site 714962002136 PYR/PP interface [polypeptide binding]; other site 714962002137 TPP binding site [chemical binding]; other site 714962002138 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 714962002139 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 714962002140 E3 interaction surface; other site 714962002141 lipoyl attachment site [posttranslational modification]; other site 714962002142 e3 binding domain; Region: E3_binding; pfam02817 714962002143 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 714962002144 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 714962002145 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 714962002146 CoA-ligase; Region: Ligase_CoA; pfam00549 714962002147 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 714962002148 CoA binding domain; Region: CoA_binding; smart00881 714962002149 CoA-ligase; Region: Ligase_CoA; pfam00549 714962002150 TPR repeat; Region: TPR_11; pfam13414 714962002151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714962002152 binding surface 714962002153 TPR motif; other site 714962002154 Tetratricopeptide repeat; Region: TPR_12; pfam13424 714962002155 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 714962002156 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 714962002157 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 714962002158 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 714962002159 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 714962002160 hypothetical protein; Provisional; Region: PRK10588 714962002161 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 714962002162 active site 714962002163 colicin uptake protein TolQ; Provisional; Region: PRK10801 714962002164 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 714962002165 colicin uptake protein TolR; Provisional; Region: PRK11024 714962002166 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 714962002167 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 714962002168 TolA C-terminal; Region: TolA; pfam06519 714962002169 translocation protein TolB; Provisional; Region: tolB; PRK03629 714962002170 TolB amino-terminal domain; Region: TolB_N; pfam04052 714962002171 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 714962002172 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 714962002173 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 714962002174 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 714962002175 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 714962002176 ligand binding site [chemical binding]; other site 714962002177 tol-pal system protein YbgF; Provisional; Region: PRK10803 714962002178 Tetratricopeptide repeat; Region: TPR_6; pfam13174 714962002179 Tetratricopeptide repeat; Region: TPR_6; pfam13174 714962002180 quinolinate synthetase; Provisional; Region: PRK09375 714962002181 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 714962002182 zinc transporter ZitB; Provisional; Region: PRK03557 714962002183 YbgS-like protein; Region: YbgS; pfam13985 714962002184 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 714962002185 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 714962002186 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714962002187 catalytic core [active] 714962002188 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714962002189 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 714962002190 active site 714962002191 catalytic residues [active] 714962002192 galactokinase; Provisional; Region: PRK05101 714962002193 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 714962002194 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 714962002195 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 714962002196 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 714962002197 dimer interface [polypeptide binding]; other site 714962002198 active site 714962002199 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 714962002200 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 714962002201 NAD binding site [chemical binding]; other site 714962002202 homodimer interface [polypeptide binding]; other site 714962002203 active site 714962002204 substrate binding site [chemical binding]; other site 714962002205 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 714962002206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 714962002207 Walker A/P-loop; other site 714962002208 ATP binding site [chemical binding]; other site 714962002209 Q-loop/lid; other site 714962002210 ABC transporter signature motif; other site 714962002211 Walker B; other site 714962002212 D-loop; other site 714962002213 H-loop/switch region; other site 714962002214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962002215 Walker A/P-loop; other site 714962002216 ATP binding site [chemical binding]; other site 714962002217 Q-loop/lid; other site 714962002218 ABC transporter signature motif; other site 714962002219 Walker B; other site 714962002220 D-loop; other site 714962002221 H-loop/switch region; other site 714962002222 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 714962002223 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 714962002224 molybdenum-pterin binding domain; Region: Mop; TIGR00638 714962002225 TOBE domain; Region: TOBE; pfam03459 714962002226 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 714962002227 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 714962002228 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714962002229 substrate binding pocket [chemical binding]; other site 714962002230 membrane-bound complex binding site; other site 714962002231 hinge residues; other site 714962002232 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 714962002233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962002234 dimer interface [polypeptide binding]; other site 714962002235 conserved gate region; other site 714962002236 putative PBP binding loops; other site 714962002237 ABC-ATPase subunit interface; other site 714962002238 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 714962002239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962002240 Walker A/P-loop; other site 714962002241 ATP binding site [chemical binding]; other site 714962002242 Q-loop/lid; other site 714962002243 ABC transporter signature motif; other site 714962002244 Walker B; other site 714962002245 D-loop; other site 714962002246 H-loop/switch region; other site 714962002247 molybdenum-pterin binding domain; Region: Mop; TIGR00638 714962002248 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 714962002249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962002250 motif II; other site 714962002251 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962002252 6-phosphogluconolactonase; Provisional; Region: PRK11028 714962002253 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714962002254 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962002255 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 714962002256 putative dimerization interface [polypeptide binding]; other site 714962002257 PrpF protein; Region: PrpF; pfam04303 714962002258 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 714962002259 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 714962002260 transmembrane helices; other site 714962002261 putative hydratase; Provisional; Region: PRK11413 714962002262 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 714962002263 substrate binding site [chemical binding]; other site 714962002264 ligand binding site [chemical binding]; other site 714962002265 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 714962002266 substrate binding site [chemical binding]; other site 714962002267 acyl-CoA thioesterase; Provisional; Region: PRK10531 714962002268 putative pectinesterase; Region: PLN02432; cl01911 714962002269 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 714962002270 substrate binding site [chemical binding]; other site 714962002271 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 714962002272 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714962002273 inhibitor-cofactor binding pocket; inhibition site 714962002274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962002275 catalytic residue [active] 714962002276 biotin synthase; Provisional; Region: PRK15108 714962002277 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714962002278 FeS/SAM binding site; other site 714962002279 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 714962002280 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 714962002281 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 714962002282 substrate-cofactor binding pocket; other site 714962002283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962002284 catalytic residue [active] 714962002285 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 714962002286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962002287 S-adenosylmethionine binding site [chemical binding]; other site 714962002288 AAA domain; Region: AAA_26; pfam13500 714962002289 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 714962002290 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 714962002291 ADP binding site [chemical binding]; other site 714962002292 excinuclease ABC subunit B; Provisional; Region: PRK05298 714962002293 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714962002294 ATP binding site [chemical binding]; other site 714962002295 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714962002296 nucleotide binding region [chemical binding]; other site 714962002297 ATP-binding site [chemical binding]; other site 714962002298 Ultra-violet resistance protein B; Region: UvrB; pfam12344 714962002299 UvrB/uvrC motif; Region: UVR; pfam02151 714962002300 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 714962002301 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 714962002302 putative substrate binding pocket [chemical binding]; other site 714962002303 dimer interface [polypeptide binding]; other site 714962002304 phosphate binding site [ion binding]; other site 714962002305 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 714962002306 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714962002307 FeS/SAM binding site; other site 714962002308 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 714962002309 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 714962002310 MPT binding site; other site 714962002311 trimer interface [polypeptide binding]; other site 714962002312 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 714962002313 trimer interface [polypeptide binding]; other site 714962002314 dimer interface [polypeptide binding]; other site 714962002315 putative active site [active] 714962002316 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 714962002317 MoaE interaction surface [polypeptide binding]; other site 714962002318 MoeB interaction surface [polypeptide binding]; other site 714962002319 thiocarboxylated glycine; other site 714962002320 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 714962002321 MoaE homodimer interface [polypeptide binding]; other site 714962002322 MoaD interaction [polypeptide binding]; other site 714962002323 active site residues [active] 714962002324 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 714962002325 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 714962002326 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 714962002327 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 714962002328 Predicted integral membrane protein [Function unknown]; Region: COG0392 714962002329 cardiolipin synthase 2; Provisional; Region: PRK11263 714962002330 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 714962002331 putative active site [active] 714962002332 catalytic site [active] 714962002333 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 714962002334 putative active site [active] 714962002335 catalytic site [active] 714962002336 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 714962002337 putative catalytic site [active] 714962002338 putative metal binding site [ion binding]; other site 714962002339 putative phosphate binding site [ion binding]; other site 714962002340 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 714962002341 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 714962002342 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 714962002343 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 714962002344 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 714962002345 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714962002346 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 714962002347 Walker A/P-loop; other site 714962002348 ATP binding site [chemical binding]; other site 714962002349 Q-loop/lid; other site 714962002350 ABC transporter signature motif; other site 714962002351 Walker B; other site 714962002352 D-loop; other site 714962002353 H-loop/switch region; other site 714962002354 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 714962002355 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 714962002356 Walker A/P-loop; other site 714962002357 ATP binding site [chemical binding]; other site 714962002358 Q-loop/lid; other site 714962002359 ABC transporter signature motif; other site 714962002360 Walker B; other site 714962002361 D-loop; other site 714962002362 H-loop/switch region; other site 714962002363 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 714962002364 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 714962002365 HlyD family secretion protein; Region: HlyD_3; pfam13437 714962002366 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 714962002367 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 714962002368 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 714962002369 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 714962002370 ATP binding site [chemical binding]; other site 714962002371 Mg++ binding site [ion binding]; other site 714962002372 motif III; other site 714962002373 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714962002374 nucleotide binding region [chemical binding]; other site 714962002375 ATP-binding site [chemical binding]; other site 714962002376 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 714962002377 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 714962002378 DEAD_2; Region: DEAD_2; pfam06733 714962002379 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 714962002380 glycosyl transferase family protein; Provisional; Region: PRK08136 714962002381 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 714962002382 putative dehydrogenase; Provisional; Region: PRK10098 714962002383 hypothetical protein; Provisional; Region: PRK10259 714962002384 hypothetical protein; Provisional; Region: PRK11019 714962002385 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 714962002386 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 714962002387 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 714962002388 N-terminal plug; other site 714962002389 ligand-binding site [chemical binding]; other site 714962002390 hypothetical protein; Provisional; Region: PRK10259 714962002391 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 714962002392 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 714962002393 putative mechanosensitive channel protein; Provisional; Region: PRK11465 714962002394 Mechanosensitive ion channel; Region: MS_channel; pfam00924 714962002395 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 714962002396 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 714962002397 Walker A/P-loop; other site 714962002398 ATP binding site [chemical binding]; other site 714962002399 Q-loop/lid; other site 714962002400 ABC transporter signature motif; other site 714962002401 Walker B; other site 714962002402 D-loop; other site 714962002403 H-loop/switch region; other site 714962002404 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 714962002405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962002406 dimer interface [polypeptide binding]; other site 714962002407 conserved gate region; other site 714962002408 putative PBP binding loops; other site 714962002409 ABC-ATPase subunit interface; other site 714962002410 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 714962002411 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714962002412 substrate binding pocket [chemical binding]; other site 714962002413 membrane-bound complex binding site; other site 714962002414 hinge residues; other site 714962002415 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 714962002416 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 714962002417 dimerization interface [polypeptide binding]; other site 714962002418 DPS ferroxidase diiron center [ion binding]; other site 714962002419 ion pore; other site 714962002420 threonine and homoserine efflux system; Provisional; Region: PRK10532 714962002421 EamA-like transporter family; Region: EamA; pfam00892 714962002422 outer membrane protein X; Provisional; Region: ompX; PRK09408 714962002423 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 714962002424 Sulfatase; Region: Sulfatase; pfam00884 714962002425 manganese transport regulator MntR; Provisional; Region: PRK11050 714962002426 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 714962002427 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 714962002428 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 714962002429 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 714962002430 transmembrane helices; other site 714962002431 L,D-transpeptidase; Provisional; Region: PRK10260 714962002432 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 714962002433 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 714962002434 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962002435 Walker A/P-loop; other site 714962002436 ATP binding site [chemical binding]; other site 714962002437 Q-loop/lid; other site 714962002438 ABC transporter signature motif; other site 714962002439 Walker B; other site 714962002440 D-loop; other site 714962002441 H-loop/switch region; other site 714962002442 ABC transporter; Region: ABC_tran_2; pfam12848 714962002443 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714962002444 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 714962002445 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962002446 active site 714962002447 motif I; other site 714962002448 motif II; other site 714962002449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962002450 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 714962002451 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 714962002452 dimer interface [polypeptide binding]; other site 714962002453 active site 714962002454 glycine loop; other site 714962002455 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 714962002456 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 714962002457 active site 714962002458 intersubunit interactions; other site 714962002459 catalytic residue [active] 714962002460 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 714962002461 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 714962002462 ATP binding site [chemical binding]; other site 714962002463 substrate interface [chemical binding]; other site 714962002464 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 714962002465 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 714962002466 dimer interface [polypeptide binding]; other site 714962002467 putative functional site; other site 714962002468 putative MPT binding site; other site 714962002469 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 714962002470 catalytic nucleophile [active] 714962002471 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 714962002472 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714962002473 Walker A/P-loop; other site 714962002474 ATP binding site [chemical binding]; other site 714962002475 Q-loop/lid; other site 714962002476 ABC transporter signature motif; other site 714962002477 Walker B; other site 714962002478 D-loop; other site 714962002479 H-loop/switch region; other site 714962002480 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 714962002481 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714962002482 Walker A/P-loop; other site 714962002483 ATP binding site [chemical binding]; other site 714962002484 Q-loop/lid; other site 714962002485 ABC transporter signature motif; other site 714962002486 Walker B; other site 714962002487 D-loop; other site 714962002488 H-loop/switch region; other site 714962002489 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 714962002490 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 714962002491 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 714962002492 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 714962002493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962002494 dimer interface [polypeptide binding]; other site 714962002495 conserved gate region; other site 714962002496 putative PBP binding loops; other site 714962002497 ABC-ATPase subunit interface; other site 714962002498 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 714962002499 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 714962002500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962002501 dimer interface [polypeptide binding]; other site 714962002502 conserved gate region; other site 714962002503 putative PBP binding loops; other site 714962002504 ABC-ATPase subunit interface; other site 714962002505 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714962002506 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 714962002507 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714962002508 metal binding site [ion binding]; metal-binding site 714962002509 active site 714962002510 I-site; other site 714962002511 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 714962002512 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 714962002513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714962002514 FeS/SAM binding site; other site 714962002515 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 714962002516 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 714962002517 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 714962002518 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 714962002519 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 714962002520 putative C-terminal domain interface [polypeptide binding]; other site 714962002521 putative GSH binding site (G-site) [chemical binding]; other site 714962002522 putative dimer interface [polypeptide binding]; other site 714962002523 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 714962002524 N-terminal domain interface [polypeptide binding]; other site 714962002525 dimer interface [polypeptide binding]; other site 714962002526 substrate binding pocket (H-site) [chemical binding]; other site 714962002527 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 714962002528 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 714962002529 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 714962002530 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 714962002531 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 714962002532 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 714962002533 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 714962002534 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 714962002535 active site 714962002536 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 714962002537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962002538 putative substrate translocation pore; other site 714962002539 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 714962002540 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962002541 active site 714962002542 motif I; other site 714962002543 motif II; other site 714962002544 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962002545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962002546 putative substrate translocation pore; other site 714962002547 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714962002548 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 714962002549 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714962002550 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 714962002551 putative transporter; Provisional; Region: PRK04972 714962002552 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 714962002553 TrkA-C domain; Region: TrkA_C; pfam02080 714962002554 TrkA-C domain; Region: TrkA_C; pfam02080 714962002555 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 714962002556 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 714962002557 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 714962002558 GSH binding site [chemical binding]; other site 714962002559 catalytic residues [active] 714962002560 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 714962002561 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 714962002562 dimer interface [polypeptide binding]; other site 714962002563 FMN binding site [chemical binding]; other site 714962002564 NADPH bind site [chemical binding]; other site 714962002565 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 714962002566 RimK-like ATP-grasp domain; Region: RimK; pfam08443 714962002567 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 714962002568 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 714962002569 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 714962002570 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 714962002571 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962002572 Walker A/P-loop; other site 714962002573 ATP binding site [chemical binding]; other site 714962002574 Q-loop/lid; other site 714962002575 ABC transporter signature motif; other site 714962002576 Walker B; other site 714962002577 D-loop; other site 714962002578 H-loop/switch region; other site 714962002579 TOBE domain; Region: TOBE_2; pfam08402 714962002580 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 714962002581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962002582 dimer interface [polypeptide binding]; other site 714962002583 conserved gate region; other site 714962002584 putative PBP binding loops; other site 714962002585 ABC-ATPase subunit interface; other site 714962002586 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 714962002587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962002588 dimer interface [polypeptide binding]; other site 714962002589 conserved gate region; other site 714962002590 putative PBP binding loops; other site 714962002591 ABC-ATPase subunit interface; other site 714962002592 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 714962002593 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 714962002594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962002595 S-adenosylmethionine binding site [chemical binding]; other site 714962002596 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 714962002597 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714962002598 substrate binding pocket [chemical binding]; other site 714962002599 membrane-bound complex binding site; other site 714962002600 hinge residues; other site 714962002601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962002602 dimer interface [polypeptide binding]; other site 714962002603 conserved gate region; other site 714962002604 putative PBP binding loops; other site 714962002605 ABC-ATPase subunit interface; other site 714962002606 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 714962002607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962002608 dimer interface [polypeptide binding]; other site 714962002609 conserved gate region; other site 714962002610 putative PBP binding loops; other site 714962002611 ABC-ATPase subunit interface; other site 714962002612 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 714962002613 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714962002614 substrate binding pocket [chemical binding]; other site 714962002615 membrane-bound complex binding site; other site 714962002616 hinge residues; other site 714962002617 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 714962002618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962002619 Walker A/P-loop; other site 714962002620 ATP binding site [chemical binding]; other site 714962002621 Q-loop/lid; other site 714962002622 ABC transporter signature motif; other site 714962002623 Walker B; other site 714962002624 D-loop; other site 714962002625 H-loop/switch region; other site 714962002626 putative lipoprotein; Provisional; Region: PRK10533 714962002627 hypothetical protein; Provisional; Region: PRK02877 714962002628 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 714962002629 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 714962002630 amidase catalytic site [active] 714962002631 Zn binding residues [ion binding]; other site 714962002632 substrate binding site [chemical binding]; other site 714962002633 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 714962002634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714962002635 NAD(P) binding site [chemical binding]; other site 714962002636 active site 714962002637 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 714962002638 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 714962002639 putative NAD(P) binding site [chemical binding]; other site 714962002640 putative active site [active] 714962002641 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 714962002642 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 714962002643 tetramer interface [polypeptide binding]; other site 714962002644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962002645 catalytic residue [active] 714962002646 pyruvate dehydrogenase; Provisional; Region: PRK09124 714962002647 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 714962002648 PYR/PP interface [polypeptide binding]; other site 714962002649 dimer interface [polypeptide binding]; other site 714962002650 tetramer interface [polypeptide binding]; other site 714962002651 TPP binding site [chemical binding]; other site 714962002652 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 714962002653 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 714962002654 TPP-binding site [chemical binding]; other site 714962002655 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 714962002656 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 714962002657 FAD binding pocket [chemical binding]; other site 714962002658 FAD binding motif [chemical binding]; other site 714962002659 phosphate binding motif [ion binding]; other site 714962002660 beta-alpha-beta structure motif; other site 714962002661 NAD binding pocket [chemical binding]; other site 714962002662 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 714962002663 catalytic loop [active] 714962002664 iron binding site [ion binding]; other site 714962002665 hybrid cluster protein; Provisional; Region: PRK05290 714962002666 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 714962002667 ACS interaction site; other site 714962002668 CODH interaction site; other site 714962002669 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 714962002670 hybrid metal cluster; other site 714962002671 Predicted membrane protein [Function unknown]; Region: COG2431 714962002672 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 714962002673 amphipathic channel; other site 714962002674 Asn-Pro-Ala signature motifs; other site 714962002675 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 714962002676 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 714962002677 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 714962002678 putative active site [active] 714962002679 putative metal-binding site [ion binding]; other site 714962002680 Protein of unknown function (DUF535); Region: DUF535; pfam04393 714962002681 macrolide transporter subunit MacA; Provisional; Region: PRK11578 714962002682 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 714962002683 HlyD family secretion protein; Region: HlyD_3; pfam13437 714962002684 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 714962002685 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 714962002686 Walker A/P-loop; other site 714962002687 ATP binding site [chemical binding]; other site 714962002688 Q-loop/lid; other site 714962002689 ABC transporter signature motif; other site 714962002690 Walker B; other site 714962002691 D-loop; other site 714962002692 H-loop/switch region; other site 714962002693 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 714962002694 FtsX-like permease family; Region: FtsX; pfam02687 714962002695 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 714962002696 DNA-binding site [nucleotide binding]; DNA binding site 714962002697 RNA-binding motif; other site 714962002698 integrase; Provisional; Region: PRK09692 714962002699 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 714962002700 active site 714962002701 Int/Topo IB signature motif; other site 714962002702 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 714962002703 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 714962002704 D5 N terminal like; Region: D5_N; smart00885 714962002705 Phage associated DNA primase [General function prediction only]; Region: COG3378 714962002706 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 714962002707 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 714962002708 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 714962002709 ssDNA binding site [nucleotide binding]; other site 714962002710 dimer interface [polypeptide binding]; other site 714962002711 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714962002712 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 714962002713 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 714962002714 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 714962002715 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 714962002716 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 714962002717 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 714962002718 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 714962002719 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 714962002720 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 714962002721 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 714962002722 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 714962002723 rRNA binding site [nucleotide binding]; other site 714962002724 predicted 30S ribosome binding site; other site 714962002725 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 714962002726 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 714962002727 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714962002728 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 714962002729 Walker A/P-loop; other site 714962002730 ATP binding site [chemical binding]; other site 714962002731 Q-loop/lid; other site 714962002732 ABC transporter signature motif; other site 714962002733 Walker B; other site 714962002734 D-loop; other site 714962002735 H-loop/switch region; other site 714962002736 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 714962002737 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714962002738 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962002739 Walker A/P-loop; other site 714962002740 ATP binding site [chemical binding]; other site 714962002741 Q-loop/lid; other site 714962002742 ABC transporter signature motif; other site 714962002743 Walker B; other site 714962002744 D-loop; other site 714962002745 H-loop/switch region; other site 714962002746 thioredoxin reductase; Provisional; Region: PRK10262 714962002747 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714962002748 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714962002749 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 714962002750 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714962002751 putative DNA binding site [nucleotide binding]; other site 714962002752 putative Zn2+ binding site [ion binding]; other site 714962002753 AsnC family; Region: AsnC_trans_reg; pfam01037 714962002754 DNA translocase FtsK; Provisional; Region: PRK10263 714962002755 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 714962002756 DNA translocase FtsK; Provisional; Region: PRK10263 714962002757 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 714962002758 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 714962002759 periplasmic chaperone LolA; Region: lolA; TIGR00547 714962002760 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 714962002761 recombination factor protein RarA; Reviewed; Region: PRK13342 714962002762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962002763 Walker A motif; other site 714962002764 ATP binding site [chemical binding]; other site 714962002765 Walker B motif; other site 714962002766 arginine finger; other site 714962002767 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 714962002768 seryl-tRNA synthetase; Provisional; Region: PRK05431 714962002769 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 714962002770 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 714962002771 dimer interface [polypeptide binding]; other site 714962002772 active site 714962002773 motif 1; other site 714962002774 motif 2; other site 714962002775 motif 3; other site 714962002776 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 714962002777 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 714962002778 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 714962002779 putative [Fe4-S4] binding site [ion binding]; other site 714962002780 putative molybdopterin cofactor binding site [chemical binding]; other site 714962002781 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 714962002782 putative molybdopterin cofactor binding site; other site 714962002783 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 714962002784 4Fe-4S binding domain; Region: Fer4; pfam00037 714962002785 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 714962002786 Isochorismatase family; Region: Isochorismatase; pfam00857 714962002787 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 714962002788 catalytic triad [active] 714962002789 dimer interface [polypeptide binding]; other site 714962002790 conserved cis-peptide bond; other site 714962002791 putative MFS family transporter protein; Provisional; Region: PRK03633 714962002792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962002793 putative substrate translocation pore; other site 714962002794 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 714962002795 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714962002796 FeS/SAM binding site; other site 714962002797 integrase; Provisional; Region: int; PHA02601 714962002798 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 714962002799 active site 714962002800 DNA binding site [nucleotide binding] 714962002801 Int/Topo IB signature motif; other site 714962002802 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 714962002803 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 714962002804 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 714962002805 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 714962002806 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 714962002807 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 714962002808 DksA-like zinc finger domain containing protein; Region: PHA00080 714962002809 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 714962002810 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 714962002811 portal vertex protein; Provisional; Region: Q; PHA02536 714962002812 Phage portal protein; Region: Phage_portal; pfam04860 714962002813 terminase ATPase subunit; Provisional; Region: P; PHA02535 714962002814 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 714962002815 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 714962002816 Phage major capsid protein, P2 family; Region: Phage_cap_P2; pfam05125 714962002817 terminase endonuclease subunit; Provisional; Region: M; PHA02537 714962002818 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 714962002819 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 714962002820 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 714962002821 Phage holin family 2; Region: Phage_holin_2; pfam04550 714962002822 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 714962002823 N-acetyl-D-glucosamine binding site [chemical binding]; other site 714962002824 catalytic residue [active] 714962002825 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 714962002826 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 714962002827 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 714962002828 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 714962002829 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 714962002830 baseplate wedge subunit; Provisional; Region: W; PHA02516 714962002831 baseplate assembly protein; Provisional; Region: J; PHA02568 714962002832 phage tail protein, P2 protein I family; Region: tail_P2_I; TIGR01634 714962002833 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 714962002834 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 714962002835 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 714962002836 major tail sheath protein; Provisional; Region: FI; PHA02560 714962002837 major tail tube protein; Provisional; Region: FII; PHA02600 714962002838 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 714962002839 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 714962002840 tail protein; Provisional; Region: D; PHA02561 714962002841 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 714962002842 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 714962002843 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 714962002844 Pyruvate formate lyase 1; Region: PFL1; cd01678 714962002845 coenzyme A binding site [chemical binding]; other site 714962002846 active site 714962002847 catalytic residues [active] 714962002848 glycine loop; other site 714962002849 formate transporter; Provisional; Region: PRK10805 714962002850 uncharacterized domain; Region: TIGR00702 714962002851 YcaO-like family; Region: YcaO; pfam02624 714962002852 Predicted membrane protein [Function unknown]; Region: COG2323 714962002853 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 714962002854 homodimer interface [polypeptide binding]; other site 714962002855 substrate-cofactor binding pocket; other site 714962002856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962002857 catalytic residue [active] 714962002858 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 714962002859 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 714962002860 hinge; other site 714962002861 active site 714962002862 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 714962002863 cytidylate kinase; Provisional; Region: cmk; PRK00023 714962002864 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 714962002865 CMP-binding site; other site 714962002866 The sites determining sugar specificity; other site 714962002867 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 714962002868 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 714962002869 RNA binding site [nucleotide binding]; other site 714962002870 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 714962002871 RNA binding site [nucleotide binding]; other site 714962002872 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 714962002873 RNA binding site [nucleotide binding]; other site 714962002874 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 714962002875 RNA binding site [nucleotide binding]; other site 714962002876 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 714962002877 RNA binding site [nucleotide binding]; other site 714962002878 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 714962002879 IHF dimer interface [polypeptide binding]; other site 714962002880 IHF - DNA interface [nucleotide binding]; other site 714962002881 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 714962002882 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714962002883 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 714962002884 Walker A/P-loop; other site 714962002885 ATP binding site [chemical binding]; other site 714962002886 Q-loop/lid; other site 714962002887 ABC transporter signature motif; other site 714962002888 Walker B; other site 714962002889 D-loop; other site 714962002890 H-loop/switch region; other site 714962002891 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 714962002892 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 714962002893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 714962002894 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 714962002895 hypothetical protein; Provisional; Region: PRK11827 714962002896 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 714962002897 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 714962002898 Ligand binding site; other site 714962002899 oligomer interface; other site 714962002900 hypothetical protein; Provisional; Region: PRK10593 714962002901 Uncharacterized conserved protein [Function unknown]; Region: COG1434 714962002902 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 714962002903 putative active site [active] 714962002904 Methyltransferase domain; Region: Methyltransf_31; pfam13847 714962002905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962002906 S-adenosylmethionine binding site [chemical binding]; other site 714962002907 condesin subunit F; Provisional; Region: PRK05260 714962002908 condesin subunit E; Provisional; Region: PRK05256 714962002909 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 714962002910 MukB N-terminal; Region: MukB; pfam04310 714962002911 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 714962002912 murein L,D-transpeptidase; Provisional; Region: PRK10594 714962002913 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 714962002914 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 714962002915 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 714962002916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 714962002917 Peptidase M15; Region: Peptidase_M15_3; cl01194 714962002918 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 714962002919 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 714962002920 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714962002921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962002922 homodimer interface [polypeptide binding]; other site 714962002923 catalytic residue [active] 714962002924 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 714962002925 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 714962002926 trimer interface [polypeptide binding]; other site 714962002927 eyelet of channel; other site 714962002928 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 714962002929 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 714962002930 putative dimer interface [polypeptide binding]; other site 714962002931 putative anticodon binding site; other site 714962002932 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 714962002933 homodimer interface [polypeptide binding]; other site 714962002934 motif 1; other site 714962002935 motif 2; other site 714962002936 active site 714962002937 motif 3; other site 714962002938 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 714962002939 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 714962002940 active site 714962002941 aminopeptidase N; Provisional; Region: pepN; PRK14015 714962002942 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 714962002943 active site 714962002944 Zn binding site [ion binding]; other site 714962002945 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 714962002946 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 714962002947 Walker A/P-loop; other site 714962002948 ATP binding site [chemical binding]; other site 714962002949 Q-loop/lid; other site 714962002950 ABC transporter signature motif; other site 714962002951 Walker B; other site 714962002952 D-loop; other site 714962002953 H-loop/switch region; other site 714962002954 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 714962002955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962002956 dimer interface [polypeptide binding]; other site 714962002957 conserved gate region; other site 714962002958 putative PBP binding loops; other site 714962002959 ABC-ATPase subunit interface; other site 714962002960 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 714962002961 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 714962002962 active site 714962002963 dimer interface [polypeptide binding]; other site 714962002964 non-prolyl cis peptide bond; other site 714962002965 insertion regions; other site 714962002966 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714962002967 substrate binding pocket [chemical binding]; other site 714962002968 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 714962002969 membrane-bound complex binding site; other site 714962002970 hinge residues; other site 714962002971 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 714962002972 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 714962002973 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 714962002974 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 714962002975 quinone interaction residues [chemical binding]; other site 714962002976 active site 714962002977 catalytic residues [active] 714962002978 FMN binding site [chemical binding]; other site 714962002979 substrate binding site [chemical binding]; other site 714962002980 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 714962002981 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 714962002982 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 714962002983 MOSC domain; Region: MOSC; pfam03473 714962002984 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 714962002985 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 714962002986 catalytic loop [active] 714962002987 iron binding site [ion binding]; other site 714962002988 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 714962002989 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 714962002990 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 714962002991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962002992 S-adenosylmethionine binding site [chemical binding]; other site 714962002993 ABC transporter ATPase component; Reviewed; Region: PRK11147 714962002994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962002995 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962002996 Walker A/P-loop; other site 714962002997 Walker A/P-loop; other site 714962002998 ATP binding site [chemical binding]; other site 714962002999 ATP binding site [chemical binding]; other site 714962003000 Q-loop/lid; other site 714962003001 Q-loop/lid; other site 714962003002 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714962003003 ABC transporter signature motif; other site 714962003004 Walker B; other site 714962003005 D-loop; other site 714962003006 ABC transporter; Region: ABC_tran_2; pfam12848 714962003007 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714962003008 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 714962003009 Paraquat-inducible protein A; Region: PqiA; pfam04403 714962003010 Paraquat-inducible protein A; Region: PqiA; pfam04403 714962003011 paraquat-inducible protein B; Provisional; Region: PRK10807 714962003012 mce related protein; Region: MCE; pfam02470 714962003013 mce related protein; Region: MCE; pfam02470 714962003014 mce related protein; Region: MCE; pfam02470 714962003015 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 714962003016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 714962003017 Protein of unknown function (DUF330); Region: DUF330; pfam03886 714962003018 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 714962003019 active site 1 [active] 714962003020 dimer interface [polypeptide binding]; other site 714962003021 active site 2 [active] 714962003022 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 714962003023 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 714962003024 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 714962003025 outer membrane protein A; Reviewed; Region: PRK10808 714962003026 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 714962003027 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 714962003028 ligand binding site [chemical binding]; other site 714962003029 cell division inhibitor SulA; Region: sula; TIGR00623 714962003030 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 714962003031 TfoX C-terminal domain; Region: TfoX_C; pfam04994 714962003032 TIGR01666 family membrane protein; Region: YCCS 714962003033 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 714962003034 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 714962003035 Predicted membrane protein [Function unknown]; Region: COG3304 714962003036 Domain of unknown function (DUF307); Region: DUF307; pfam03733 714962003037 Domain of unknown function (DUF307); Region: DUF307; pfam03733 714962003038 DNA helicase IV; Provisional; Region: helD; PRK11054 714962003039 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 714962003040 Part of AAA domain; Region: AAA_19; pfam13245 714962003041 Family description; Region: UvrD_C_2; pfam13538 714962003042 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 714962003043 active site 714962003044 dimer interfaces [polypeptide binding]; other site 714962003045 catalytic residues [active] 714962003046 hypothetical protein; Provisional; Region: PRK03641 714962003047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 714962003048 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 714962003049 heat shock protein HspQ; Provisional; Region: PRK14129 714962003050 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 714962003051 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 714962003052 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 714962003053 putative RNA binding site [nucleotide binding]; other site 714962003054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962003055 S-adenosylmethionine binding site [chemical binding]; other site 714962003056 Acylphosphatase; Region: Acylphosphatase; cl00551 714962003057 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 714962003058 sulfur transfer protein TusE; Provisional; Region: PRK11508 714962003059 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 714962003060 YccA-like proteins; Region: YccA_like; cd10433 714962003061 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 714962003062 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 714962003063 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 714962003064 hydrogenase 1 large subunit; Provisional; Region: PRK10170 714962003065 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 714962003066 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 714962003067 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 714962003068 putative substrate-binding site; other site 714962003069 nickel binding site [ion binding]; other site 714962003070 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 714962003071 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 714962003072 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 714962003073 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 714962003074 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 714962003075 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 714962003076 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 714962003077 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 714962003078 catalytic core [active] 714962003079 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 714962003080 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 714962003081 DNA-binding site [nucleotide binding]; DNA binding site 714962003082 RNA-binding motif; other site 714962003083 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 714962003084 DNA-binding site [nucleotide binding]; DNA binding site 714962003085 RNA-binding motif; other site 714962003086 GnsA/GnsB family; Region: GnsAB; pfam08178 714962003087 4Fe-4S binding domain; Region: Fer4_5; pfam12801 714962003088 4Fe-4S binding domain; Region: Fer4_5; pfam12801 714962003089 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 714962003090 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 714962003091 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 714962003092 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 714962003093 dimerization interface [polypeptide binding]; other site 714962003094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962003095 dimer interface [polypeptide binding]; other site 714962003096 phosphorylation site [posttranslational modification] 714962003097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962003098 ATP binding site [chemical binding]; other site 714962003099 Mg2+ binding site [ion binding]; other site 714962003100 G-X-G motif; other site 714962003101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962003102 active site 714962003103 phosphorylation site [posttranslational modification] 714962003104 intermolecular recognition site; other site 714962003105 dimerization interface [polypeptide binding]; other site 714962003106 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 714962003107 putative binding surface; other site 714962003108 active site 714962003109 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 714962003110 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 714962003111 putative ligand binding site [chemical binding]; other site 714962003112 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 714962003113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962003114 active site 714962003115 phosphorylation site [posttranslational modification] 714962003116 intermolecular recognition site; other site 714962003117 dimerization interface [polypeptide binding]; other site 714962003118 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714962003119 DNA binding site [nucleotide binding] 714962003120 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 714962003121 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 714962003122 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 714962003123 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 714962003124 molybdopterin cofactor binding site [chemical binding]; other site 714962003125 substrate binding site [chemical binding]; other site 714962003126 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 714962003127 molybdopterin cofactor binding site; other site 714962003128 chaperone protein TorD; Validated; Region: torD; PRK04976 714962003129 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 714962003130 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 714962003131 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 714962003132 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 714962003133 HSP70 interaction site [polypeptide binding]; other site 714962003134 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 714962003135 substrate binding site [polypeptide binding]; other site 714962003136 dimer interface [polypeptide binding]; other site 714962003137 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 714962003138 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 714962003139 catalytic core [active] 714962003140 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 714962003141 hypothetical protein; Provisional; Region: PRK10174 714962003142 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 714962003143 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 714962003144 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 714962003145 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 714962003146 putative FMN binding site [chemical binding]; other site 714962003147 pyrimidine utilization protein D; Region: RutD; TIGR03611 714962003148 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 714962003149 homotrimer interaction site [polypeptide binding]; other site 714962003150 putative active site [active] 714962003151 Isochorismatase family; Region: Isochorismatase; pfam00857 714962003152 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 714962003153 catalytic triad [active] 714962003154 conserved cis-peptide bond; other site 714962003155 pyrimidine utilization protein A; Region: RutA; TIGR03612 714962003156 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 714962003157 active site 714962003158 dimer interface [polypeptide binding]; other site 714962003159 non-prolyl cis peptide bond; other site 714962003160 insertion regions; other site 714962003161 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 714962003162 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 714962003163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714962003164 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 714962003165 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 714962003166 Predicted transcriptional regulator [Transcription]; Region: COG3905 714962003167 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 714962003168 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 714962003169 Glutamate binding site [chemical binding]; other site 714962003170 NAD binding site [chemical binding]; other site 714962003171 catalytic residues [active] 714962003172 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 714962003173 Na binding site [ion binding]; other site 714962003174 FTR1 family protein; Region: TIGR00145 714962003175 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 714962003176 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 714962003177 Imelysin; Region: Peptidase_M75; pfam09375 714962003178 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 714962003179 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 714962003180 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 714962003181 N-glycosyltransferase; Provisional; Region: PRK11204 714962003182 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 714962003183 DXD motif; other site 714962003184 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 714962003185 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 714962003186 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 714962003187 putative active site [active] 714962003188 putative metal binding site [ion binding]; other site 714962003189 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 714962003190 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 714962003191 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714962003192 metal binding site [ion binding]; metal-binding site 714962003193 active site 714962003194 I-site; other site 714962003195 integrase; Provisional; Region: PRK09692 714962003196 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 714962003197 active site 714962003198 Int/Topo IB signature motif; other site 714962003199 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 714962003200 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 714962003201 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 714962003202 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 714962003203 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 714962003204 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714962003205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962003206 homodimer interface [polypeptide binding]; other site 714962003207 catalytic residue [active] 714962003208 FaeA-like protein; Region: FaeA; pfam04703 714962003209 Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333 714962003210 Fimbrial protein; Region: Fimbrial; cl01416 714962003211 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 714962003212 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 714962003213 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 714962003214 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 714962003215 outer membrane usher protein; Provisional; Region: PRK15193 714962003216 PapC N-terminal domain; Region: PapC_N; pfam13954 714962003217 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 714962003218 PapC C-terminal domain; Region: PapC_C; pfam13953 714962003219 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 714962003220 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 714962003221 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 714962003222 mannosyl binding site [chemical binding]; other site 714962003223 Fimbrial protein; Region: Fimbrial; pfam00419 714962003224 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714962003225 MarR family; Region: MarR_2; cl17246 714962003226 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 714962003227 outer membrane receptor FepA; Provisional; Region: PRK13528 714962003228 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 714962003229 N-terminal plug; other site 714962003230 ligand-binding site [chemical binding]; other site 714962003231 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 714962003232 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 714962003233 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 714962003234 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 714962003235 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714962003236 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 714962003237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962003238 Walker A/P-loop; other site 714962003239 ATP binding site [chemical binding]; other site 714962003240 Q-loop/lid; other site 714962003241 ABC transporter signature motif; other site 714962003242 Walker B; other site 714962003243 D-loop; other site 714962003244 H-loop/switch region; other site 714962003245 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 714962003246 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714962003247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962003248 Walker A/P-loop; other site 714962003249 ATP binding site [chemical binding]; other site 714962003250 Q-loop/lid; other site 714962003251 ABC transporter signature motif; other site 714962003252 Walker B; other site 714962003253 D-loop; other site 714962003254 H-loop/switch region; other site 714962003255 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 714962003256 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 714962003257 homodimer interface [polypeptide binding]; other site 714962003258 active site 714962003259 TDP-binding site; other site 714962003260 acceptor substrate-binding pocket; other site 714962003261 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 714962003262 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 714962003263 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 714962003264 N-terminal plug; other site 714962003265 ligand-binding site [chemical binding]; other site 714962003266 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 714962003267 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 714962003268 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 714962003269 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 714962003270 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 714962003271 Sel1-like repeats; Region: SEL1; smart00671 714962003272 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 714962003273 Sel1-like repeats; Region: SEL1; smart00671 714962003274 Sel1-like repeats; Region: SEL1; smart00671 714962003275 Sel1-like repeats; Region: SEL1; smart00671 714962003276 Sel1-like repeats; Region: SEL1; smart00671 714962003277 Sel1-like repeats; Region: SEL1; smart00671 714962003278 Sel1-like repeats; Region: SEL1; smart00671 714962003279 Sel1-like repeats; Region: SEL1; smart00671 714962003280 Sel1-like repeats; Region: SEL1; smart00671 714962003281 Predicted GTPase [General function prediction only]; Region: COG3596 714962003282 YfjP GTPase; Region: YfjP; cd11383 714962003283 G1 box; other site 714962003284 GTP/Mg2+ binding site [chemical binding]; other site 714962003285 Switch I region; other site 714962003286 G2 box; other site 714962003287 Switch II region; other site 714962003288 G3 box; other site 714962003289 G4 box; other site 714962003290 G5 box; other site 714962003291 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 714962003292 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 714962003293 hypothetical protein; Provisional; Region: PRK09945 714962003294 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 714962003295 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 714962003296 Autotransporter beta-domain; Region: Autotransporter; smart00869 714962003297 Domain of unknown function (DUF932); Region: DUF932; pfam06067 714962003298 Antirestriction protein; Region: Antirestrict; pfam03230 714962003299 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 714962003300 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 714962003301 MPN+ (JAMM) motif; other site 714962003302 Zinc-binding site [ion binding]; other site 714962003303 Protein of unknown function (DUF987); Region: DUF987; pfam06174 714962003304 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 714962003305 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 714962003306 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 714962003307 Methyltransferase domain; Region: Methyltransf_27; pfam13708 714962003308 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 714962003309 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 714962003310 putative ligand binding site [chemical binding]; other site 714962003311 NAD binding site [chemical binding]; other site 714962003312 dimerization interface [polypeptide binding]; other site 714962003313 catalytic site [active] 714962003314 putative hydrolase; Validated; Region: PRK09248 714962003315 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 714962003316 active site 714962003317 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 714962003318 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 714962003319 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 714962003320 curli assembly protein CsgF; Provisional; Region: PRK10050 714962003321 curli assembly protein CsgE; Provisional; Region: PRK10386 714962003322 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 714962003323 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714962003324 DNA binding residues [nucleotide binding] 714962003325 dimerization interface [polypeptide binding]; other site 714962003326 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 714962003327 Curlin associated repeat; Region: Curlin_rpt; pfam07012 714962003328 Curlin associated repeat; Region: Curlin_rpt; pfam07012 714962003329 major curlin subunit; Provisional; Region: csgA; PRK10051 714962003330 Curlin associated repeat; Region: Curlin_rpt; pfam07012 714962003331 Curlin associated repeat; Region: Curlin_rpt; pfam07012 714962003332 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 714962003333 Fimbrial protein; Region: Fimbrial; cl01416 714962003334 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 714962003335 putative ADP-ribose binding site [chemical binding]; other site 714962003336 putative active site [active] 714962003337 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 714962003338 PLD-like domain; Region: PLDc_2; pfam13091 714962003339 putative active site [active] 714962003340 catalytic site [active] 714962003341 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 714962003342 PLD-like domain; Region: PLDc_2; pfam13091 714962003343 putative active site [active] 714962003344 catalytic site [active] 714962003345 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 714962003346 Acyltransferase family; Region: Acyl_transf_3; pfam01757 714962003347 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 714962003348 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 714962003349 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 714962003350 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 714962003351 Ligand binding site; other site 714962003352 DXD motif; other site 714962003353 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 714962003354 lipoprotein; Provisional; Region: PRK10175 714962003355 secY/secA suppressor protein; Provisional; Region: PRK11467 714962003356 drug efflux system protein MdtG; Provisional; Region: PRK09874 714962003357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962003358 putative substrate translocation pore; other site 714962003359 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 714962003360 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 714962003361 putative acyl-acceptor binding pocket; other site 714962003362 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 714962003363 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 714962003364 active site residue [active] 714962003365 hypothetical protein; Provisional; Region: PRK03757 714962003366 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 714962003367 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 714962003368 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 714962003369 hydroxyglutarate oxidase; Provisional; Region: PRK11728 714962003370 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 714962003371 DNA damage-inducible protein I; Provisional; Region: PRK10597 714962003372 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 714962003373 active site 714962003374 substrate binding pocket [chemical binding]; other site 714962003375 dimer interface [polypeptide binding]; other site 714962003376 lipoprotein; Provisional; Region: PRK10598 714962003377 glutaredoxin 2; Provisional; Region: PRK10387 714962003378 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 714962003379 C-terminal domain interface [polypeptide binding]; other site 714962003380 GSH binding site (G-site) [chemical binding]; other site 714962003381 catalytic residues [active] 714962003382 putative dimer interface [polypeptide binding]; other site 714962003383 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 714962003384 N-terminal domain interface [polypeptide binding]; other site 714962003385 multidrug resistance protein MdtH; Provisional; Region: PRK11646 714962003386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962003387 putative substrate translocation pore; other site 714962003388 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 714962003389 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714962003390 hypothetical protein; Provisional; Region: PRK11239 714962003391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 714962003392 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 714962003393 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 714962003394 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 714962003395 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 714962003396 MviN-like protein; Region: MVIN; pfam03023 714962003397 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 714962003398 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 714962003399 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 714962003400 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 714962003401 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 714962003402 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 714962003403 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 714962003404 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 714962003405 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 714962003406 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 714962003407 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 714962003408 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 714962003409 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 714962003410 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 714962003411 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 714962003412 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 714962003413 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 714962003414 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 714962003415 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 714962003416 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 714962003417 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 714962003418 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 714962003419 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 714962003420 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 714962003421 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 714962003422 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 714962003423 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 714962003424 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 714962003425 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 714962003426 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 714962003427 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 714962003428 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 714962003429 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 714962003430 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 714962003431 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 714962003432 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 714962003433 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 714962003434 homodimer interface [polypeptide binding]; other site 714962003435 oligonucleotide binding site [chemical binding]; other site 714962003436 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 714962003437 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 714962003438 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714962003439 RNA binding surface [nucleotide binding]; other site 714962003440 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 714962003441 active site 714962003442 Maf-like protein; Region: Maf; pfam02545 714962003443 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 714962003444 active site 714962003445 dimer interface [polypeptide binding]; other site 714962003446 hypothetical protein; Provisional; Region: PRK11193 714962003447 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 714962003448 putative phosphate acyltransferase; Provisional; Region: PRK05331 714962003449 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 714962003450 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 714962003451 dimer interface [polypeptide binding]; other site 714962003452 active site 714962003453 CoA binding pocket [chemical binding]; other site 714962003454 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 714962003455 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 714962003456 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 714962003457 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 714962003458 NAD(P) binding site [chemical binding]; other site 714962003459 homotetramer interface [polypeptide binding]; other site 714962003460 homodimer interface [polypeptide binding]; other site 714962003461 active site 714962003462 acyl carrier protein; Provisional; Region: acpP; PRK00982 714962003463 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 714962003464 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 714962003465 dimer interface [polypeptide binding]; other site 714962003466 active site 714962003467 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 714962003468 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 714962003469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962003470 catalytic residue [active] 714962003471 conserved hypothetical protein, YceG family; Region: TIGR00247 714962003472 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 714962003473 dimerization interface [polypeptide binding]; other site 714962003474 thymidylate kinase; Validated; Region: tmk; PRK00698 714962003475 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 714962003476 TMP-binding site; other site 714962003477 ATP-binding site [chemical binding]; other site 714962003478 DNA polymerase III subunit delta'; Validated; Region: PRK07993 714962003479 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 714962003480 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 714962003481 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 714962003482 active site 714962003483 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 714962003484 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 714962003485 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714962003486 active site turn [active] 714962003487 phosphorylation site [posttranslational modification] 714962003488 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 714962003489 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 714962003490 N-terminal plug; other site 714962003491 ligand-binding site [chemical binding]; other site 714962003492 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 714962003493 nucleotide binding site/active site [active] 714962003494 HIT family signature motif; other site 714962003495 catalytic residue [active] 714962003496 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 714962003497 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 714962003498 putative dimer interface [polypeptide binding]; other site 714962003499 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 714962003500 thiamine kinase; Region: ycfN_thiK; TIGR02721 714962003501 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 714962003502 active site 714962003503 substrate binding site [chemical binding]; other site 714962003504 ATP binding site [chemical binding]; other site 714962003505 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 714962003506 beta-hexosaminidase; Provisional; Region: PRK05337 714962003507 hypothetical protein; Provisional; Region: PRK04940 714962003508 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 714962003509 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714962003510 hypothetical protein; Provisional; Region: PRK11280 714962003511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714962003512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714962003513 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 714962003514 L,D-transpeptidase; Provisional; Region: PRK10260 714962003515 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 714962003516 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 714962003517 transcription-repair coupling factor; Provisional; Region: PRK10689 714962003518 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 714962003519 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714962003520 ATP binding site [chemical binding]; other site 714962003521 putative Mg++ binding site [ion binding]; other site 714962003522 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714962003523 nucleotide binding region [chemical binding]; other site 714962003524 ATP-binding site [chemical binding]; other site 714962003525 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 714962003526 Predicted membrane protein [Function unknown]; Region: COG4763 714962003527 Acyltransferase family; Region: Acyl_transf_3; pfam01757 714962003528 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 714962003529 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 714962003530 FtsX-like permease family; Region: FtsX; pfam02687 714962003531 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 714962003532 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 714962003533 Walker A/P-loop; other site 714962003534 ATP binding site [chemical binding]; other site 714962003535 Q-loop/lid; other site 714962003536 ABC transporter signature motif; other site 714962003537 Walker B; other site 714962003538 D-loop; other site 714962003539 H-loop/switch region; other site 714962003540 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 714962003541 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 714962003542 FtsX-like permease family; Region: FtsX; pfam02687 714962003543 fructokinase; Reviewed; Region: PRK09557 714962003544 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 714962003545 nucleotide binding site [chemical binding]; other site 714962003546 NAD-dependent deacetylase; Provisional; Region: PRK00481 714962003547 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 714962003548 NAD+ binding site [chemical binding]; other site 714962003549 substrate binding site [chemical binding]; other site 714962003550 Zn binding site [ion binding]; other site 714962003551 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 714962003552 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 714962003553 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 714962003554 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 714962003555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962003556 dimer interface [polypeptide binding]; other site 714962003557 conserved gate region; other site 714962003558 putative PBP binding loops; other site 714962003559 ABC-ATPase subunit interface; other site 714962003560 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 714962003561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962003562 dimer interface [polypeptide binding]; other site 714962003563 conserved gate region; other site 714962003564 putative PBP binding loops; other site 714962003565 ABC-ATPase subunit interface; other site 714962003566 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 714962003567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962003568 Walker A/P-loop; other site 714962003569 ATP binding site [chemical binding]; other site 714962003570 Q-loop/lid; other site 714962003571 ABC transporter signature motif; other site 714962003572 Walker B; other site 714962003573 D-loop; other site 714962003574 H-loop/switch region; other site 714962003575 TOBE domain; Region: TOBE_2; pfam08402 714962003576 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 714962003577 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 714962003578 metal binding site [ion binding]; metal-binding site 714962003579 dimer interface [polypeptide binding]; other site 714962003580 Uncharacterized conserved protein [Function unknown]; Region: COG2850 714962003581 Cupin-like domain; Region: Cupin_8; pfam13621 714962003582 sensor protein PhoQ; Provisional; Region: PRK10815 714962003583 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 714962003584 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 714962003585 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 714962003586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962003587 ATP binding site [chemical binding]; other site 714962003588 Mg2+ binding site [ion binding]; other site 714962003589 G-X-G motif; other site 714962003590 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 714962003591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962003592 active site 714962003593 phosphorylation site [posttranslational modification] 714962003594 intermolecular recognition site; other site 714962003595 dimerization interface [polypeptide binding]; other site 714962003596 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714962003597 DNA binding site [nucleotide binding] 714962003598 adenylosuccinate lyase; Provisional; Region: PRK09285 714962003599 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 714962003600 tetramer interface [polypeptide binding]; other site 714962003601 active site 714962003602 putative lysogenization regulator; Reviewed; Region: PRK00218 714962003603 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 714962003604 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 714962003605 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 714962003606 nudix motif; other site 714962003607 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 714962003608 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 714962003609 probable active site [active] 714962003610 isocitrate dehydrogenase; Validated; Region: PRK07362 714962003611 isocitrate dehydrogenase; Reviewed; Region: PRK07006 714962003612 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 714962003613 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 714962003614 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 714962003615 dimer interface [polypeptide binding]; other site 714962003616 active site 714962003617 Int/Topo IB signature motif; other site 714962003618 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 714962003619 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 714962003620 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 714962003621 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 714962003622 phage recombination protein Bet; Region: bet_lambda; TIGR01913 714962003623 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 714962003624 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 714962003625 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 714962003626 Antirestriction protein Ral; Region: Ral; pfam11058 714962003627 Superinfection exclusion protein B; Region: SieB; pfam14163 714962003628 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 714962003629 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 714962003630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714962003631 non-specific DNA binding site [nucleotide binding]; other site 714962003632 salt bridge; other site 714962003633 sequence-specific DNA binding site [nucleotide binding]; other site 714962003634 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 714962003635 Catalytic site [active] 714962003636 Bacteriophage CII protein; Region: Phage_CII; pfam05269 714962003637 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 714962003638 Replication protein P; Region: Phage_lambda_P; pfam06992 714962003639 NinB protein; Region: NinB; pfam05772 714962003640 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 714962003641 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 714962003642 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 714962003643 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 714962003644 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 714962003645 trimer interface [polypeptide binding]; other site 714962003646 eyelet of channel; other site 714962003647 Lysis protein S; Region: Lysis_S; pfam04971 714962003648 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 714962003649 catalytic residues [active] 714962003650 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 714962003651 Bor protein; Region: Lambda_Bor; pfam06291 714962003652 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 714962003653 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 714962003654 gpW; Region: gpW; pfam02831 714962003655 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 714962003656 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 714962003657 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 714962003658 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 714962003659 DNA packaging protein FI; Region: Packaging_FI; pfam14000 714962003660 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 714962003661 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 714962003662 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 714962003663 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 714962003664 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 714962003665 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 714962003666 Minor tail protein T; Region: Phage_tail_T; cl05636 714962003667 Phage-related minor tail protein [Function unknown]; Region: COG5281 714962003668 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 714962003669 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 714962003670 Phage-related protein [Function unknown]; Region: COG4718 714962003671 Phage-related protein [Function unknown]; Region: gp18; COG4672 714962003672 Phage-related protein, tail component [Function unknown]; Region: COG4723 714962003673 Phage-related protein, tail component [Function unknown]; Region: COG4733 714962003674 Putative phage tail protein; Region: Phage-tail_3; pfam13550 714962003675 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 714962003676 Interdomain contacts; other site 714962003677 Cytokine receptor motif; other site 714962003678 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 714962003679 Fibronectin type III protein; Region: DUF3672; pfam12421 714962003680 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 714962003681 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 714962003682 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 714962003683 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714962003684 ABC-ATPase subunit interface; other site 714962003685 dimer interface [polypeptide binding]; other site 714962003686 putative PBP binding regions; other site 714962003687 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 714962003688 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714962003689 ABC-ATPase subunit interface; other site 714962003690 dimer interface [polypeptide binding]; other site 714962003691 putative PBP binding regions; other site 714962003692 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 714962003693 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 714962003694 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 714962003695 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 714962003696 metal binding site [ion binding]; metal-binding site 714962003697 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 714962003698 transcriptional regulator MirA; Provisional; Region: PRK15043 714962003699 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 714962003700 DNA binding residues [nucleotide binding] 714962003701 Sensors of blue-light using FAD; Region: BLUF; smart01034 714962003702 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714962003703 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 714962003704 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714962003705 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 714962003706 Autotransporter beta-domain; Region: Autotransporter; cl17461 714962003707 Autotransporter beta-domain; Region: Autotransporter; smart00869 714962003708 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 714962003709 cell division inhibitor MinD; Provisional; Region: PRK10818 714962003710 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 714962003711 Switch I; other site 714962003712 Switch II; other site 714962003713 septum formation inhibitor; Reviewed; Region: minC; PRK03511 714962003714 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 714962003715 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 714962003716 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 714962003717 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 714962003718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 714962003719 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 714962003720 hypothetical protein; Provisional; Region: PRK10691 714962003721 hypothetical protein; Provisional; Region: PRK05170 714962003722 Haemolysin E (HlyE); Region: HlyE; cl11627 714962003723 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 714962003724 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 714962003725 Catalytic site [active] 714962003726 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 714962003727 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 714962003728 active site 714962003729 DNA binding site [nucleotide binding] 714962003730 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 714962003731 disulfide bond formation protein B; Provisional; Region: PRK01749 714962003732 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 714962003733 transmembrane helices; other site 714962003734 fatty acid metabolism regulator; Provisional; Region: PRK04984 714962003735 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962003736 DNA-binding site [nucleotide binding]; DNA binding site 714962003737 FadR C-terminal domain; Region: FadR_C; pfam07840 714962003738 SpoVR family protein; Provisional; Region: PRK11767 714962003739 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 714962003740 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 714962003741 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714962003742 alanine racemase; Reviewed; Region: dadX; PRK03646 714962003743 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 714962003744 active site 714962003745 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 714962003746 substrate binding site [chemical binding]; other site 714962003747 catalytic residues [active] 714962003748 dimer interface [polypeptide binding]; other site 714962003749 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 714962003750 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 714962003751 TrkA-C domain; Region: TrkA_C; pfam02080 714962003752 Transporter associated domain; Region: CorC_HlyC; smart01091 714962003753 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 714962003754 dimer interface [polypeptide binding]; other site 714962003755 catalytic triad [active] 714962003756 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 714962003757 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 714962003758 N-acetyl-D-glucosamine binding site [chemical binding]; other site 714962003759 catalytic residue [active] 714962003760 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 714962003761 Flagellar regulator YcgR; Region: YcgR; pfam07317 714962003762 PilZ domain; Region: PilZ; pfam07238 714962003763 hypothetical protein; Provisional; Region: PRK10457 714962003764 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 714962003765 N-terminal plug; other site 714962003766 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 714962003767 ligand-binding site [chemical binding]; other site 714962003768 molybdenum transport protein ModD; Provisional; Region: PRK06096 714962003769 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 714962003770 dimerization interface [polypeptide binding]; other site 714962003771 active site 714962003772 Methyltransferase domain; Region: Methyltransf_31; pfam13847 714962003773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962003774 S-adenosylmethionine binding site [chemical binding]; other site 714962003775 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 714962003776 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 714962003777 Walker A/P-loop; other site 714962003778 ATP binding site [chemical binding]; other site 714962003779 Q-loop/lid; other site 714962003780 ABC transporter signature motif; other site 714962003781 Walker B; other site 714962003782 D-loop; other site 714962003783 H-loop/switch region; other site 714962003784 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 714962003785 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714962003786 ABC-ATPase subunit interface; other site 714962003787 dimer interface [polypeptide binding]; other site 714962003788 putative PBP binding regions; other site 714962003789 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 714962003790 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 714962003791 putative metal binding site [ion binding]; other site 714962003792 trehalase; Provisional; Region: treA; PRK13271 714962003793 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 714962003794 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 714962003795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 714962003796 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 714962003797 dimerization domain swap beta strand [polypeptide binding]; other site 714962003798 regulatory protein interface [polypeptide binding]; other site 714962003799 active site 714962003800 regulatory phosphorylation site [posttranslational modification]; other site 714962003801 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 714962003802 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 714962003803 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 714962003804 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 714962003805 Dak1 domain; Region: Dak1; pfam02733 714962003806 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 714962003807 PAS domain; Region: PAS; smart00091 714962003808 putative active site [active] 714962003809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962003810 Walker A motif; other site 714962003811 ATP binding site [chemical binding]; other site 714962003812 Walker B motif; other site 714962003813 arginine finger; other site 714962003814 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 714962003815 Probable pectinesterase/pectinesterase inhibitor; Region: PLN02708 714962003816 GTP-binding protein YchF; Reviewed; Region: PRK09601 714962003817 YchF GTPase; Region: YchF; cd01900 714962003818 G1 box; other site 714962003819 GTP/Mg2+ binding site [chemical binding]; other site 714962003820 Switch I region; other site 714962003821 G2 box; other site 714962003822 Switch II region; other site 714962003823 G3 box; other site 714962003824 G4 box; other site 714962003825 G5 box; other site 714962003826 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 714962003827 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 714962003828 putative active site [active] 714962003829 catalytic residue [active] 714962003830 hypothetical protein; Provisional; Region: PRK10692 714962003831 putative transporter; Provisional; Region: PRK11660 714962003832 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 714962003833 Sulfate transporter family; Region: Sulfate_transp; pfam00916 714962003834 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 714962003835 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 714962003836 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 714962003837 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714962003838 active site 714962003839 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 714962003840 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 714962003841 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 714962003842 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 714962003843 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 714962003844 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 714962003845 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 714962003846 tRNA; other site 714962003847 putative tRNA binding site [nucleotide binding]; other site 714962003848 putative NADP binding site [chemical binding]; other site 714962003849 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 714962003850 peptide chain release factor 1; Validated; Region: prfA; PRK00591 714962003851 This domain is found in peptide chain release factors; Region: PCRF; smart00937 714962003852 RF-1 domain; Region: RF-1; pfam00472 714962003853 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 714962003854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962003855 hypothetical protein; Provisional; Region: PRK10278 714962003856 hypothetical protein; Provisional; Region: PRK10941 714962003857 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 714962003858 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 714962003859 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 714962003860 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 714962003861 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 714962003862 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 714962003863 cation transport regulator; Reviewed; Region: chaB; PRK09582 714962003864 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 714962003865 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 714962003866 putative active site pocket [active] 714962003867 dimerization interface [polypeptide binding]; other site 714962003868 putative catalytic residue [active] 714962003869 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 714962003870 putative invasin; Provisional; Region: PRK10177 714962003871 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 714962003872 transcriptional regulator NarL; Provisional; Region: PRK10651 714962003873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962003874 active site 714962003875 phosphorylation site [posttranslational modification] 714962003876 intermolecular recognition site; other site 714962003877 dimerization interface [polypeptide binding]; other site 714962003878 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714962003879 DNA binding residues [nucleotide binding] 714962003880 dimerization interface [polypeptide binding]; other site 714962003881 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 714962003882 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 714962003883 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714962003884 dimerization interface [polypeptide binding]; other site 714962003885 Histidine kinase; Region: HisKA_3; pfam07730 714962003886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962003887 ATP binding site [chemical binding]; other site 714962003888 Mg2+ binding site [ion binding]; other site 714962003889 G-X-G motif; other site 714962003890 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 714962003891 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 714962003892 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 714962003893 [4Fe-4S] binding site [ion binding]; other site 714962003894 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 714962003895 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 714962003896 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 714962003897 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 714962003898 molybdopterin cofactor binding site; other site 714962003899 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 714962003900 4Fe-4S binding domain; Region: Fer4; cl02805 714962003901 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 714962003902 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 714962003903 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 714962003904 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 714962003905 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 714962003906 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 714962003907 putative active site [active] 714962003908 putative substrate binding site [chemical binding]; other site 714962003909 putative cosubstrate binding site; other site 714962003910 catalytic site [active] 714962003911 SEC-C motif; Region: SEC-C; pfam02810 714962003912 hypothetical protein; Provisional; Region: PRK04233 714962003913 hypothetical protein; Provisional; Region: PRK10279 714962003914 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 714962003915 active site 714962003916 nucleophile elbow; other site 714962003917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962003918 active site 714962003919 response regulator of RpoS; Provisional; Region: PRK10693 714962003920 phosphorylation site [posttranslational modification] 714962003921 intermolecular recognition site; other site 714962003922 dimerization interface [polypeptide binding]; other site 714962003923 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 714962003924 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 714962003925 active site 714962003926 tetramer interface; other site 714962003927 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 714962003928 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 714962003929 thymidine kinase; Provisional; Region: PRK04296 714962003930 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 714962003931 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 714962003932 putative catalytic cysteine [active] 714962003933 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 714962003934 putative active site [active] 714962003935 metal binding site [ion binding]; metal-binding site 714962003936 hypothetical protein; Provisional; Region: PRK11111 714962003937 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 714962003938 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714962003939 peptide binding site [polypeptide binding]; other site 714962003940 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 714962003941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962003942 dimer interface [polypeptide binding]; other site 714962003943 conserved gate region; other site 714962003944 putative PBP binding loops; other site 714962003945 ABC-ATPase subunit interface; other site 714962003946 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 714962003947 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 714962003948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962003949 dimer interface [polypeptide binding]; other site 714962003950 conserved gate region; other site 714962003951 putative PBP binding loops; other site 714962003952 ABC-ATPase subunit interface; other site 714962003953 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 714962003954 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714962003955 Walker A/P-loop; other site 714962003956 ATP binding site [chemical binding]; other site 714962003957 Q-loop/lid; other site 714962003958 ABC transporter signature motif; other site 714962003959 Walker B; other site 714962003960 D-loop; other site 714962003961 H-loop/switch region; other site 714962003962 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 714962003963 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 714962003964 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714962003965 Walker A/P-loop; other site 714962003966 ATP binding site [chemical binding]; other site 714962003967 Q-loop/lid; other site 714962003968 ABC transporter signature motif; other site 714962003969 Walker B; other site 714962003970 D-loop; other site 714962003971 H-loop/switch region; other site 714962003972 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 714962003973 dsDNA-mimic protein; Reviewed; Region: PRK05094 714962003974 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 714962003975 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 714962003976 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 714962003977 putative active site [active] 714962003978 catalytic site [active] 714962003979 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 714962003980 putative active site [active] 714962003981 catalytic site [active] 714962003982 voltage-gated potassium channel; Provisional; Region: PRK10537 714962003983 Ion channel; Region: Ion_trans_2; pfam07885 714962003984 TrkA-N domain; Region: TrkA_N; pfam02254 714962003985 YciI-like protein; Reviewed; Region: PRK11370 714962003986 transport protein TonB; Provisional; Region: PRK10819 714962003987 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 714962003988 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 714962003989 intracellular septation protein A; Reviewed; Region: PRK00259 714962003990 outer membrane protein W; Provisional; Region: PRK10959 714962003991 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 714962003992 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 714962003993 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 714962003994 dimer interface [polypeptide binding]; other site 714962003995 active site 714962003996 Int/Topo IB signature motif; other site 714962003997 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 714962003998 active site 714962003999 catalytic site [active] 714962004000 substrate binding site [chemical binding]; other site 714962004001 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 714962004002 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 714962004003 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714962004004 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 714962004005 non-specific DNA binding site [nucleotide binding]; other site 714962004006 salt bridge; other site 714962004007 sequence-specific DNA binding site [nucleotide binding]; other site 714962004008 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 714962004009 Catalytic site [active] 714962004010 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 714962004011 primosomal protein DnaI; Provisional; Region: PRK02854 714962004012 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 714962004013 Protein of unknown function (DUF968); Region: DUF968; pfam06147 714962004014 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 714962004015 Antitermination protein; Region: Antiterm; pfam03589 714962004016 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 714962004017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962004018 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 714962004019 DNA methylase; Region: N6_N4_Mtase; pfam01555 714962004020 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 714962004021 Lysis protein S; Region: Lysis_S; pfam04971 714962004022 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 714962004023 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 714962004024 catalytic residues [active] 714962004025 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 714962004026 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 714962004027 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 714962004028 gpW; Region: gpW; pfam02831 714962004029 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 714962004030 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 714962004031 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 714962004032 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 714962004033 tandem repeat interface [polypeptide binding]; other site 714962004034 oligomer interface [polypeptide binding]; other site 714962004035 active site residues [active] 714962004036 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 714962004037 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 714962004038 DNA packaging protein FI; Region: Packaging_FI; pfam14000 714962004039 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 714962004040 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 714962004041 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 714962004042 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 714962004043 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 714962004044 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 714962004045 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 714962004046 Phage-related minor tail protein [Function unknown]; Region: COG5281 714962004047 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 714962004048 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 714962004049 Phage-related protein [Function unknown]; Region: COG4718 714962004050 Phage-related protein [Function unknown]; Region: gp18; COG4672 714962004051 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 714962004052 MPN+ (JAMM) motif; other site 714962004053 Zinc-binding site [ion binding]; other site 714962004054 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 714962004055 NlpC/P60 family; Region: NLPC_P60; cl17555 714962004056 Phage-related protein, tail component [Function unknown]; Region: COG4723 714962004057 Phage-related protein, tail component [Function unknown]; Region: COG4733 714962004058 Putative phage tail protein; Region: Phage-tail_3; pfam13550 714962004059 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 714962004060 Fibronectin type III protein; Region: DUF3672; pfam12421 714962004061 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 714962004062 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 714962004063 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 714962004064 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 714962004065 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 714962004066 Phage Tail Collar Domain; Region: Collar; pfam07484 714962004067 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 714962004068 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 714962004069 Methyltransferase domain; Region: Methyltransf_31; pfam13847 714962004070 Methyltransferase domain; Region: Methyltransf_12; pfam08242 714962004071 S-adenosylmethionine binding site [chemical binding]; other site 714962004072 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 714962004073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 714962004074 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 714962004075 dimerization interface [polypeptide binding]; other site 714962004076 metal binding site [ion binding]; metal-binding site 714962004077 General stress protein [General function prediction only]; Region: GsiB; COG3729 714962004078 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 714962004079 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 714962004080 substrate binding site [chemical binding]; other site 714962004081 active site 714962004082 catalytic residues [active] 714962004083 heterodimer interface [polypeptide binding]; other site 714962004084 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 714962004085 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 714962004086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962004087 catalytic residue [active] 714962004088 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 714962004089 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 714962004090 active site 714962004091 ribulose/triose binding site [chemical binding]; other site 714962004092 phosphate binding site [ion binding]; other site 714962004093 substrate (anthranilate) binding pocket [chemical binding]; other site 714962004094 product (indole) binding pocket [chemical binding]; other site 714962004095 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 714962004096 active site 714962004097 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 714962004098 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 714962004099 glutamine binding [chemical binding]; other site 714962004100 catalytic triad [active] 714962004101 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 714962004102 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 714962004103 anthranilate synthase component I; Provisional; Region: PRK13564 714962004104 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 714962004105 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 714962004106 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 714962004107 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 714962004108 active site 714962004109 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 714962004110 hypothetical protein; Provisional; Region: PRK11630 714962004111 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 714962004112 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 714962004113 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714962004114 RNA binding surface [nucleotide binding]; other site 714962004115 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 714962004116 probable active site [active] 714962004117 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 714962004118 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 714962004119 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 714962004120 homodimer interface [polypeptide binding]; other site 714962004121 Walker A motif; other site 714962004122 ATP binding site [chemical binding]; other site 714962004123 hydroxycobalamin binding site [chemical binding]; other site 714962004124 Walker B motif; other site 714962004125 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 714962004126 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 714962004127 NADP binding site [chemical binding]; other site 714962004128 homodimer interface [polypeptide binding]; other site 714962004129 active site 714962004130 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 714962004131 putative inner membrane peptidase; Provisional; Region: PRK11778 714962004132 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 714962004133 tandem repeat interface [polypeptide binding]; other site 714962004134 oligomer interface [polypeptide binding]; other site 714962004135 active site residues [active] 714962004136 hypothetical protein; Provisional; Region: PRK11037 714962004137 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 714962004138 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 714962004139 active site 714962004140 interdomain interaction site; other site 714962004141 putative metal-binding site [ion binding]; other site 714962004142 nucleotide binding site [chemical binding]; other site 714962004143 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 714962004144 domain I; other site 714962004145 DNA binding groove [nucleotide binding] 714962004146 phosphate binding site [ion binding]; other site 714962004147 domain II; other site 714962004148 domain III; other site 714962004149 nucleotide binding site [chemical binding]; other site 714962004150 catalytic site [active] 714962004151 domain IV; other site 714962004152 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 714962004153 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 714962004154 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 714962004155 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 714962004156 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 714962004157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962004158 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 714962004159 substrate binding site [chemical binding]; other site 714962004160 putative dimerization interface [polypeptide binding]; other site 714962004161 aconitate hydratase; Validated; Region: PRK09277 714962004162 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 714962004163 substrate binding site [chemical binding]; other site 714962004164 ligand binding site [chemical binding]; other site 714962004165 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 714962004166 substrate binding site [chemical binding]; other site 714962004167 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 714962004168 dimerization interface [polypeptide binding]; other site 714962004169 active site 714962004170 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 714962004171 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 714962004172 active site 714962004173 Predicted membrane protein [Function unknown]; Region: COG3771 714962004174 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 714962004175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 714962004176 TPR motif; other site 714962004177 binding surface 714962004178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714962004179 binding surface 714962004180 TPR motif; other site 714962004181 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 714962004182 active site 714962004183 dimer interface [polypeptide binding]; other site 714962004184 translation initiation factor Sui1; Validated; Region: PRK06824 714962004185 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 714962004186 putative rRNA binding site [nucleotide binding]; other site 714962004187 lipoprotein; Provisional; Region: PRK10540 714962004188 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 714962004189 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 714962004190 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 714962004191 hypothetical protein; Provisional; Region: PRK13658 714962004192 RNase II stability modulator; Provisional; Region: PRK10060 714962004193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714962004194 putative active site [active] 714962004195 heme pocket [chemical binding]; other site 714962004196 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714962004197 metal binding site [ion binding]; metal-binding site 714962004198 active site 714962004199 I-site; other site 714962004200 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714962004201 exoribonuclease II; Provisional; Region: PRK05054 714962004202 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 714962004203 RNB domain; Region: RNB; pfam00773 714962004204 S1 RNA binding domain; Region: S1; pfam00575 714962004205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 714962004206 Uncharacterized conserved protein [Function unknown]; Region: COG2128 714962004207 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 714962004208 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 714962004209 NAD binding site [chemical binding]; other site 714962004210 homotetramer interface [polypeptide binding]; other site 714962004211 homodimer interface [polypeptide binding]; other site 714962004212 substrate binding site [chemical binding]; other site 714962004213 active site 714962004214 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714962004215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714962004216 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 714962004217 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 714962004218 HlyD family secretion protein; Region: HlyD_3; pfam13437 714962004219 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 714962004220 Protein export membrane protein; Region: SecD_SecF; cl14618 714962004221 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 714962004222 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 714962004223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962004224 putative substrate translocation pore; other site 714962004225 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 714962004226 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714962004227 Walker A/P-loop; other site 714962004228 ATP binding site [chemical binding]; other site 714962004229 Q-loop/lid; other site 714962004230 ABC transporter signature motif; other site 714962004231 Walker B; other site 714962004232 D-loop; other site 714962004233 H-loop/switch region; other site 714962004234 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 714962004235 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714962004236 Walker A/P-loop; other site 714962004237 ATP binding site [chemical binding]; other site 714962004238 Q-loop/lid; other site 714962004239 ABC transporter signature motif; other site 714962004240 Walker B; other site 714962004241 D-loop; other site 714962004242 H-loop/switch region; other site 714962004243 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 714962004244 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 714962004245 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 714962004246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962004247 dimer interface [polypeptide binding]; other site 714962004248 conserved gate region; other site 714962004249 putative PBP binding loops; other site 714962004250 ABC-ATPase subunit interface; other site 714962004251 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 714962004252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962004253 dimer interface [polypeptide binding]; other site 714962004254 conserved gate region; other site 714962004255 putative PBP binding loops; other site 714962004256 ABC-ATPase subunit interface; other site 714962004257 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714962004258 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 714962004259 peptide binding site [polypeptide binding]; other site 714962004260 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 714962004261 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 714962004262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962004263 Walker A motif; other site 714962004264 ATP binding site [chemical binding]; other site 714962004265 Walker B motif; other site 714962004266 arginine finger; other site 714962004267 phage shock protein PspA; Provisional; Region: PRK10698 714962004268 phage shock protein B; Provisional; Region: pspB; PRK09458 714962004269 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 714962004270 phage shock protein C; Region: phageshock_pspC; TIGR02978 714962004271 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 714962004272 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 714962004273 active site residue [active] 714962004274 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 714962004275 sucrose phosphorylase; Provisional; Region: PRK13840 714962004276 active site 714962004277 homodimer interface [polypeptide binding]; other site 714962004278 catalytic site [active] 714962004279 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 714962004280 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 714962004281 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 714962004282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962004283 dimer interface [polypeptide binding]; other site 714962004284 conserved gate region; other site 714962004285 putative PBP binding loops; other site 714962004286 ABC-ATPase subunit interface; other site 714962004287 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 714962004288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962004289 dimer interface [polypeptide binding]; other site 714962004290 conserved gate region; other site 714962004291 putative PBP binding loops; other site 714962004292 ABC-ATPase subunit interface; other site 714962004293 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 714962004294 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 714962004295 putative NAD(P) binding site [chemical binding]; other site 714962004296 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 714962004297 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 714962004298 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 714962004299 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 714962004300 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 714962004301 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 714962004302 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 714962004303 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 714962004304 beta-phosphoglucomutase; Region: bPGM; TIGR01990 714962004305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962004306 motif II; other site 714962004307 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 714962004308 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 714962004309 Walker A/P-loop; other site 714962004310 ATP binding site [chemical binding]; other site 714962004311 Q-loop/lid; other site 714962004312 ABC transporter signature motif; other site 714962004313 Walker B; other site 714962004314 D-loop; other site 714962004315 H-loop/switch region; other site 714962004316 TOBE domain; Region: TOBE_2; pfam08402 714962004317 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 714962004318 Transcriptional regulators [Transcription]; Region: PurR; COG1609 714962004319 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714962004320 DNA binding site [nucleotide binding] 714962004321 domain linker motif; other site 714962004322 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 714962004323 putative dimerization interface [polypeptide binding]; other site 714962004324 putative ligand binding site [chemical binding]; other site 714962004325 Predicted ATPase [General function prediction only]; Region: COG3106 714962004326 hypothetical protein; Provisional; Region: PRK05415 714962004327 TIGR01620 family protein; Region: hyp_HI0043 714962004328 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 714962004329 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 714962004330 putative aromatic amino acid binding site; other site 714962004331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962004332 Walker A motif; other site 714962004333 ATP binding site [chemical binding]; other site 714962004334 Walker B motif; other site 714962004335 arginine finger; other site 714962004336 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 714962004337 dimer interface [polypeptide binding]; other site 714962004338 catalytic triad [active] 714962004339 peroxidatic and resolving cysteines [active] 714962004340 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 714962004341 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 714962004342 active site 714962004343 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 714962004344 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 714962004345 putative active site [active] 714962004346 Zn binding site [ion binding]; other site 714962004347 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 714962004348 NADH(P)-binding; Region: NAD_binding_10; pfam13460 714962004349 putative NAD(P) binding site [chemical binding]; other site 714962004350 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 714962004351 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 714962004352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714962004353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962004354 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 714962004355 putative effector binding pocket; other site 714962004356 putative dimerization interface [polypeptide binding]; other site 714962004357 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 714962004358 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714962004359 peptide binding site [polypeptide binding]; other site 714962004360 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 714962004361 Mechanosensitive ion channel; Region: MS_channel; pfam00924 714962004362 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 714962004363 universal stress protein UspE; Provisional; Region: PRK11175 714962004364 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 714962004365 Ligand Binding Site [chemical binding]; other site 714962004366 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 714962004367 Ligand Binding Site [chemical binding]; other site 714962004368 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 714962004369 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 714962004370 ligand binding site [chemical binding]; other site 714962004371 flexible hinge region; other site 714962004372 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 714962004373 putative switch regulator; other site 714962004374 non-specific DNA interactions [nucleotide binding]; other site 714962004375 DNA binding site [nucleotide binding] 714962004376 sequence specific DNA binding site [nucleotide binding]; other site 714962004377 putative cAMP binding site [chemical binding]; other site 714962004378 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 714962004379 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 714962004380 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 714962004381 DNA binding site [nucleotide binding] 714962004382 active site 714962004383 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15356 714962004384 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 714962004385 Helix-turn-helix domain; Region: HTH_18; pfam12833 714962004386 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 714962004387 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 714962004388 HlyD family secretion protein; Region: HlyD_3; pfam13437 714962004389 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 714962004390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962004391 putative substrate translocation pore; other site 714962004392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962004393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 714962004394 Smr domain; Region: Smr; pfam01713 714962004395 PAS domain S-box; Region: sensory_box; TIGR00229 714962004396 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714962004397 putative active site [active] 714962004398 heme pocket [chemical binding]; other site 714962004399 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 714962004400 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714962004401 metal binding site [ion binding]; metal-binding site 714962004402 active site 714962004403 I-site; other site 714962004404 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 714962004405 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 714962004406 Cl binding site [ion binding]; other site 714962004407 oligomer interface [polypeptide binding]; other site 714962004408 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 714962004409 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 714962004410 ATP binding site [chemical binding]; other site 714962004411 Mg++ binding site [ion binding]; other site 714962004412 motif III; other site 714962004413 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714962004414 nucleotide binding region [chemical binding]; other site 714962004415 ATP-binding site [chemical binding]; other site 714962004416 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 714962004417 putative RNA binding site [nucleotide binding]; other site 714962004418 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 714962004419 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 714962004420 Ligand Binding Site [chemical binding]; other site 714962004421 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 714962004422 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 714962004423 DNA binding site [nucleotide binding] 714962004424 active site 714962004425 Int/Topo IB signature motif; other site 714962004426 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 714962004427 Ligand Binding Site [chemical binding]; other site 714962004428 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 714962004429 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 714962004430 trimer interface [polypeptide binding]; other site 714962004431 eyelet of channel; other site 714962004432 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 714962004433 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 714962004434 dimer interface [polypeptide binding]; other site 714962004435 PYR/PP interface [polypeptide binding]; other site 714962004436 TPP binding site [chemical binding]; other site 714962004437 substrate binding site [chemical binding]; other site 714962004438 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 714962004439 Domain of unknown function; Region: EKR; smart00890 714962004440 4Fe-4S binding domain; Region: Fer4_6; pfam12837 714962004441 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 714962004442 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 714962004443 TPP-binding site [chemical binding]; other site 714962004444 dimer interface [polypeptide binding]; other site 714962004445 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 714962004446 Domain of unknown function (DUF333); Region: DUF333; pfam03891 714962004447 heat-inducible protein; Provisional; Region: PRK10449 714962004448 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 714962004449 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 714962004450 putative ligand binding site [chemical binding]; other site 714962004451 putative NAD binding site [chemical binding]; other site 714962004452 catalytic site [active] 714962004453 hypothetical protein; Provisional; Region: PRK10695 714962004454 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 714962004455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 714962004456 Autotransporter beta-domain; Region: Autotransporter; pfam03797 714962004457 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714962004458 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714962004459 active site 714962004460 catalytic tetrad [active] 714962004461 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 714962004462 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 714962004463 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 714962004464 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 714962004465 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 714962004466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962004467 S-adenosylmethionine binding site [chemical binding]; other site 714962004468 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 714962004469 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 714962004470 active site 714962004471 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 714962004472 active site 714962004473 catalytic residues [active] 714962004474 azoreductase; Reviewed; Region: PRK00170 714962004475 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 714962004476 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 714962004477 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714962004478 ATP binding site [chemical binding]; other site 714962004479 putative Mg++ binding site [ion binding]; other site 714962004480 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714962004481 nucleotide binding region [chemical binding]; other site 714962004482 ATP-binding site [chemical binding]; other site 714962004483 Helicase associated domain (HA2); Region: HA2; pfam04408 714962004484 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 714962004485 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 714962004486 Uncharacterized conserved protein [Function unknown]; Region: COG1434 714962004487 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 714962004488 putative active site [active] 714962004489 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 714962004490 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 714962004491 NAD binding site [chemical binding]; other site 714962004492 catalytic residues [active] 714962004493 substrate binding site [chemical binding]; other site 714962004494 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 714962004495 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 714962004496 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 714962004497 cytochrome b561; Provisional; Region: PRK11513 714962004498 hypothetical protein; Provisional; Region: PRK10040 714962004499 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714962004500 dimer interface [polypeptide binding]; other site 714962004501 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 714962004502 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962004503 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714962004504 dimerization interface [polypeptide binding]; other site 714962004505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 714962004506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 714962004507 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 714962004508 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 714962004509 hypothetical protein; Provisional; Region: PRK11415 714962004510 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714962004511 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714962004512 Coenzyme A binding pocket [chemical binding]; other site 714962004513 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 714962004514 putative trimer interface [polypeptide binding]; other site 714962004515 putative CoA binding site [chemical binding]; other site 714962004516 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 714962004517 putative trimer interface [polypeptide binding]; other site 714962004518 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 714962004519 putative CoA binding site [chemical binding]; other site 714962004520 putative trimer interface [polypeptide binding]; other site 714962004521 putative CoA binding site [chemical binding]; other site 714962004522 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 714962004523 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 714962004524 gating phenylalanine in ion channel; other site 714962004525 tellurite resistance protein TehB; Provisional; Region: PRK11207 714962004526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962004527 S-adenosylmethionine binding site [chemical binding]; other site 714962004528 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 714962004529 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 714962004530 benzoate transporter; Region: benE; TIGR00843 714962004531 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 714962004532 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714962004533 non-specific DNA binding site [nucleotide binding]; other site 714962004534 salt bridge; other site 714962004535 sequence-specific DNA binding site [nucleotide binding]; other site 714962004536 Cupin domain; Region: Cupin_2; pfam07883 714962004537 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 714962004538 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 714962004539 Peptidase family U32; Region: Peptidase_U32; pfam01136 714962004540 Collagenase; Region: DUF3656; pfam12392 714962004541 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 714962004542 Helix-turn-helix; Region: HTH_3; pfam01381 714962004543 sequence-specific DNA binding site [nucleotide binding]; other site 714962004544 salt bridge; other site 714962004545 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 714962004546 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962004547 DNA-binding site [nucleotide binding]; DNA binding site 714962004548 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714962004549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962004550 homodimer interface [polypeptide binding]; other site 714962004551 catalytic residue [active] 714962004552 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 714962004553 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 714962004554 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 714962004555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962004556 Walker A/P-loop; other site 714962004557 ATP binding site [chemical binding]; other site 714962004558 Q-loop/lid; other site 714962004559 ABC transporter signature motif; other site 714962004560 Walker B; other site 714962004561 D-loop; other site 714962004562 H-loop/switch region; other site 714962004563 TOBE domain; Region: TOBE_2; pfam08402 714962004564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962004565 dimer interface [polypeptide binding]; other site 714962004566 conserved gate region; other site 714962004567 putative PBP binding loops; other site 714962004568 ABC-ATPase subunit interface; other site 714962004569 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 714962004570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962004571 ABC-ATPase subunit interface; other site 714962004572 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 714962004573 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 714962004574 tetrameric interface [polypeptide binding]; other site 714962004575 NAD binding site [chemical binding]; other site 714962004576 catalytic residues [active] 714962004577 substrate binding site [chemical binding]; other site 714962004578 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 714962004579 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 714962004580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 714962004581 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 714962004582 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714962004583 Coenzyme A binding pocket [chemical binding]; other site 714962004584 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 714962004585 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 714962004586 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 714962004587 N-terminal plug; other site 714962004588 ligand-binding site [chemical binding]; other site 714962004589 PQQ-like domain; Region: PQQ_2; pfam13360 714962004590 L-asparagine permease; Provisional; Region: PRK15049 714962004591 PAAR motif; Region: PAAR_motif; pfam05488 714962004592 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 714962004593 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 714962004594 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 714962004595 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 714962004596 Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007 714962004597 putative active site [active] 714962004598 putative Zn binding site [ion binding]; other site 714962004599 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 714962004600 hypothetical protein; Provisional; Region: PRK10281 714962004601 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 714962004602 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 714962004603 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 714962004604 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 714962004605 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 714962004606 [4Fe-4S] binding site [ion binding]; other site 714962004607 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 714962004608 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 714962004609 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 714962004610 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 714962004611 molybdopterin cofactor binding site; other site 714962004612 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 714962004613 aromatic amino acid exporter; Provisional; Region: PRK11689 714962004614 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 714962004615 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 714962004616 [4Fe-4S] binding site [ion binding]; other site 714962004617 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 714962004618 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 714962004619 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 714962004620 molybdopterin cofactor binding site; other site 714962004621 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 714962004622 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 714962004623 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 714962004624 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 714962004625 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 714962004626 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714962004627 non-specific DNA binding site [nucleotide binding]; other site 714962004628 salt bridge; other site 714962004629 sequence-specific DNA binding site [nucleotide binding]; other site 714962004630 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 714962004631 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 714962004632 NAD binding site [chemical binding]; other site 714962004633 substrate binding site [chemical binding]; other site 714962004634 catalytic Zn binding site [ion binding]; other site 714962004635 tetramer interface [polypeptide binding]; other site 714962004636 structural Zn binding site [ion binding]; other site 714962004637 malate dehydrogenase; Provisional; Region: PRK13529 714962004638 Malic enzyme, N-terminal domain; Region: malic; pfam00390 714962004639 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 714962004640 NAD(P) binding site [chemical binding]; other site 714962004641 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 714962004642 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 714962004643 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 714962004644 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 714962004645 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714962004646 putative active site [active] 714962004647 heme pocket [chemical binding]; other site 714962004648 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714962004649 putative active site [active] 714962004650 heme pocket [chemical binding]; other site 714962004651 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714962004652 metal binding site [ion binding]; metal-binding site 714962004653 active site 714962004654 I-site; other site 714962004655 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714962004656 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 714962004657 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714962004658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 714962004659 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 714962004660 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 714962004661 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 714962004662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962004663 catalytic residue [active] 714962004664 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 714962004665 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 714962004666 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 714962004667 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 714962004668 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 714962004669 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 714962004670 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 714962004671 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 714962004672 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 714962004673 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 714962004674 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 714962004675 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714962004676 FeS/SAM binding site; other site 714962004677 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 714962004678 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 714962004679 Sulfatase; Region: Sulfatase; pfam00884 714962004680 transcriptional regulator YdeO; Provisional; Region: PRK09940 714962004681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962004682 putative oxidoreductase; Provisional; Region: PRK09939 714962004683 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 714962004684 putative molybdopterin cofactor binding site [chemical binding]; other site 714962004685 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 714962004686 putative molybdopterin cofactor binding site; other site 714962004687 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 714962004688 mannosyl binding site [chemical binding]; other site 714962004689 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 714962004690 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 714962004691 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 714962004692 PapC N-terminal domain; Region: PapC_N; pfam13954 714962004693 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 714962004694 PapC C-terminal domain; Region: PapC_C; pfam13953 714962004695 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 714962004696 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 714962004697 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 714962004698 Fimbrial protein; Region: Fimbrial; cl01416 714962004699 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 714962004700 NADH(P)-binding; Region: NAD_binding_10; pfam13460 714962004701 NAD(P) binding site [chemical binding]; other site 714962004702 putative active site [active] 714962004703 HipA N-terminal domain; Region: Couple_hipA; pfam13657 714962004704 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 714962004705 HipA-like N-terminal domain; Region: HipA_N; pfam07805 714962004706 HipA-like C-terminal domain; Region: HipA_C; pfam07804 714962004707 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 714962004708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714962004709 non-specific DNA binding site [nucleotide binding]; other site 714962004710 salt bridge; other site 714962004711 sequence-specific DNA binding site [nucleotide binding]; other site 714962004712 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 714962004713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962004714 S-adenosylmethionine binding site [chemical binding]; other site 714962004715 Predicted membrane protein [Function unknown]; Region: COG3781 714962004716 altronate oxidoreductase; Provisional; Region: PRK03643 714962004717 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 714962004718 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 714962004719 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 714962004720 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714962004721 metal binding site [ion binding]; metal-binding site 714962004722 active site 714962004723 I-site; other site 714962004724 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 714962004725 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 714962004726 glutaminase; Provisional; Region: PRK00971 714962004727 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 714962004728 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 714962004729 NAD(P) binding site [chemical binding]; other site 714962004730 catalytic residues [active] 714962004731 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714962004732 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962004733 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 714962004734 putative dimerization interface [polypeptide binding]; other site 714962004735 putative arabinose transporter; Provisional; Region: PRK03545 714962004736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962004737 putative substrate translocation pore; other site 714962004738 inner membrane protein; Provisional; Region: PRK10995 714962004739 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 714962004740 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 714962004741 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 714962004742 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962004743 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962004744 hypothetical protein; Provisional; Region: PRK10106 714962004745 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 714962004746 beta-galactosidase; Region: BGL; TIGR03356 714962004747 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 714962004748 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 714962004749 trimer interface; other site 714962004750 sugar binding site [chemical binding]; other site 714962004751 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 714962004752 active site 714962004753 methionine cluster; other site 714962004754 phosphorylation site [posttranslational modification] 714962004755 metal binding site [ion binding]; metal-binding site 714962004756 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 714962004757 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 714962004758 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 714962004759 active site 714962004760 P-loop; other site 714962004761 phosphorylation site [posttranslational modification] 714962004762 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 714962004763 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962004764 DNA-binding site [nucleotide binding]; DNA binding site 714962004765 UTRA domain; Region: UTRA; pfam07702 714962004766 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 714962004767 EamA-like transporter family; Region: EamA; pfam00892 714962004768 EamA-like transporter family; Region: EamA; pfam00892 714962004769 putative transporter; Provisional; Region: PRK10054 714962004770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962004771 putative substrate translocation pore; other site 714962004772 diguanylate cyclase; Provisional; Region: PRK09894 714962004773 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 714962004774 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714962004775 metal binding site [ion binding]; metal-binding site 714962004776 active site 714962004777 I-site; other site 714962004778 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 714962004779 malonic semialdehyde reductase; Provisional; Region: PRK10538 714962004780 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 714962004781 putative NAD(P) binding site [chemical binding]; other site 714962004782 homodimer interface [polypeptide binding]; other site 714962004783 homotetramer interface [polypeptide binding]; other site 714962004784 active site 714962004785 Transcriptional regulators [Transcription]; Region: GntR; COG1802 714962004786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962004787 DNA-binding site [nucleotide binding]; DNA binding site 714962004788 FCD domain; Region: FCD; pfam07729 714962004789 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 714962004790 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 714962004791 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 714962004792 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 714962004793 metabolite-proton symporter; Region: 2A0106; TIGR00883 714962004794 putative oxidoreductase; Provisional; Region: PRK10083 714962004795 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 714962004796 putative NAD(P) binding site [chemical binding]; other site 714962004797 catalytic Zn binding site [ion binding]; other site 714962004798 structural Zn binding site [ion binding]; other site 714962004799 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 714962004800 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 714962004801 putative active site pocket [active] 714962004802 putative metal binding site [ion binding]; other site 714962004803 hypothetical protein; Provisional; Region: PRK02237 714962004804 hypothetical protein; Provisional; Region: PRK13659 714962004805 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 714962004806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714962004807 Coenzyme A binding pocket [chemical binding]; other site 714962004808 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 714962004809 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 714962004810 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 714962004811 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 714962004812 putative [Fe4-S4] binding site [ion binding]; other site 714962004813 putative molybdopterin cofactor binding site [chemical binding]; other site 714962004814 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 714962004815 putative molybdopterin cofactor binding site; other site 714962004816 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 714962004817 4Fe-4S binding domain; Region: Fer4; cl02805 714962004818 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 714962004819 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 714962004820 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 714962004821 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 714962004822 Cl- selectivity filter; other site 714962004823 Cl- binding residues [ion binding]; other site 714962004824 pore gating glutamate residue; other site 714962004825 dimer interface [polypeptide binding]; other site 714962004826 putative dithiobiotin synthetase; Provisional; Region: PRK12374 714962004827 AAA domain; Region: AAA_26; pfam13500 714962004828 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 714962004829 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 714962004830 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 714962004831 nucleotide binding site [chemical binding]; other site 714962004832 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 714962004833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962004834 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 714962004835 dimerization interface [polypeptide binding]; other site 714962004836 substrate binding pocket [chemical binding]; other site 714962004837 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 714962004838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962004839 putative substrate translocation pore; other site 714962004840 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 714962004841 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 714962004842 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 714962004843 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 714962004844 Domain of unknown function DUF20; Region: UPF0118; pfam01594 714962004845 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 714962004846 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 714962004847 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 714962004848 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 714962004849 ligand binding site [chemical binding]; other site 714962004850 homodimer interface [polypeptide binding]; other site 714962004851 NAD(P) binding site [chemical binding]; other site 714962004852 trimer interface B [polypeptide binding]; other site 714962004853 trimer interface A [polypeptide binding]; other site 714962004854 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 714962004855 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 714962004856 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 714962004857 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 714962004858 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 714962004859 Spore germination protein; Region: Spore_permease; cl17796 714962004860 dihydromonapterin reductase; Provisional; Region: PRK06483 714962004861 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 714962004862 NADP binding site [chemical binding]; other site 714962004863 substrate binding pocket [chemical binding]; other site 714962004864 active site 714962004865 GlpM protein; Region: GlpM; pfam06942 714962004866 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 714962004867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962004868 active site 714962004869 phosphorylation site [posttranslational modification] 714962004870 intermolecular recognition site; other site 714962004871 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714962004872 DNA binding site [nucleotide binding] 714962004873 sensor protein RstB; Provisional; Region: PRK10604 714962004874 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714962004875 dimerization interface [polypeptide binding]; other site 714962004876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962004877 dimer interface [polypeptide binding]; other site 714962004878 phosphorylation site [posttranslational modification] 714962004879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962004880 ATP binding site [chemical binding]; other site 714962004881 Mg2+ binding site [ion binding]; other site 714962004882 G-X-G motif; other site 714962004883 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 714962004884 fumarate hydratase; Reviewed; Region: fumC; PRK00485 714962004885 Class II fumarases; Region: Fumarase_classII; cd01362 714962004886 active site 714962004887 tetramer interface [polypeptide binding]; other site 714962004888 fumarate hydratase; Provisional; Region: PRK15389 714962004889 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 714962004890 Fumarase C-terminus; Region: Fumerase_C; pfam05683 714962004891 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 714962004892 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 714962004893 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 714962004894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 714962004895 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 714962004896 putative outer membrane porin protein; Provisional; Region: PRK11379 714962004897 glucuronide transporter; Provisional; Region: PRK09848 714962004898 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 714962004899 beta-D-glucuronidase; Provisional; Region: PRK10150 714962004900 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 714962004901 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 714962004902 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 714962004903 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714962004904 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714962004905 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 714962004906 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 714962004907 NAD binding site [chemical binding]; other site 714962004908 substrate binding site [chemical binding]; other site 714962004909 homotetramer interface [polypeptide binding]; other site 714962004910 homodimer interface [polypeptide binding]; other site 714962004911 active site 714962004912 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 714962004913 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714962004914 DNA binding site [nucleotide binding] 714962004915 domain linker motif; other site 714962004916 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 714962004917 putative dimerization interface [polypeptide binding]; other site 714962004918 putative ligand binding site [chemical binding]; other site 714962004919 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 714962004920 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 714962004921 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714962004922 active site turn [active] 714962004923 phosphorylation site [posttranslational modification] 714962004924 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 714962004925 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714962004926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962004927 homodimer interface [polypeptide binding]; other site 714962004928 catalytic residue [active] 714962004929 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 714962004930 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 714962004931 active site 714962004932 purine riboside binding site [chemical binding]; other site 714962004933 putative oxidoreductase; Provisional; Region: PRK11579 714962004934 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 714962004935 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 714962004936 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 714962004937 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 714962004938 electron transport complex protein RsxA; Provisional; Region: PRK05151 714962004939 electron transport complex protein RnfB; Provisional; Region: PRK05113 714962004940 Putative Fe-S cluster; Region: FeS; pfam04060 714962004941 4Fe-4S binding domain; Region: Fer4; pfam00037 714962004942 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 714962004943 SLBB domain; Region: SLBB; pfam10531 714962004944 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 714962004945 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 714962004946 electron transport complex protein RnfG; Validated; Region: PRK01908 714962004947 electron transport complex RsxE subunit; Provisional; Region: PRK12405 714962004948 endonuclease III; Provisional; Region: PRK10702 714962004949 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 714962004950 minor groove reading motif; other site 714962004951 helix-hairpin-helix signature motif; other site 714962004952 substrate binding pocket [chemical binding]; other site 714962004953 active site 714962004954 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 714962004955 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 714962004956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962004957 putative substrate translocation pore; other site 714962004958 POT family; Region: PTR2; pfam00854 714962004959 glutathionine S-transferase; Provisional; Region: PRK10542 714962004960 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 714962004961 C-terminal domain interface [polypeptide binding]; other site 714962004962 GSH binding site (G-site) [chemical binding]; other site 714962004963 dimer interface [polypeptide binding]; other site 714962004964 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 714962004965 N-terminal domain interface [polypeptide binding]; other site 714962004966 dimer interface [polypeptide binding]; other site 714962004967 substrate binding pocket (H-site) [chemical binding]; other site 714962004968 pyridoxamine kinase; Validated; Region: PRK05756 714962004969 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 714962004970 dimer interface [polypeptide binding]; other site 714962004971 pyridoxal binding site [chemical binding]; other site 714962004972 ATP binding site [chemical binding]; other site 714962004973 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 714962004974 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 714962004975 active site 714962004976 HIGH motif; other site 714962004977 dimer interface [polypeptide binding]; other site 714962004978 KMSKS motif; other site 714962004979 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714962004980 RNA binding surface [nucleotide binding]; other site 714962004981 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 714962004982 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 714962004983 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 714962004984 lysozyme inhibitor; Provisional; Region: PRK11372 714962004985 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 714962004986 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 714962004987 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 714962004988 transcriptional regulator SlyA; Provisional; Region: PRK03573 714962004989 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 714962004990 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 714962004991 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 714962004992 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 714962004993 HlyD family secretion protein; Region: HlyD_3; pfam13437 714962004994 Fusaric acid resistance protein family; Region: FUSC; pfam04632 714962004995 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 714962004996 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 714962004997 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 714962004998 E-class dimer interface [polypeptide binding]; other site 714962004999 P-class dimer interface [polypeptide binding]; other site 714962005000 active site 714962005001 Cu2+ binding site [ion binding]; other site 714962005002 Zn2+ binding site [ion binding]; other site 714962005003 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714962005004 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714962005005 active site 714962005006 catalytic tetrad [active] 714962005007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714962005008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714962005009 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 714962005010 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 714962005011 FMN binding site [chemical binding]; other site 714962005012 active site 714962005013 substrate binding site [chemical binding]; other site 714962005014 catalytic residue [active] 714962005015 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714962005016 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 714962005017 dimer interface [polypeptide binding]; other site 714962005018 active site 714962005019 metal binding site [ion binding]; metal-binding site 714962005020 glutathione binding site [chemical binding]; other site 714962005021 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 714962005022 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 714962005023 dimer interface [polypeptide binding]; other site 714962005024 catalytic site [active] 714962005025 putative active site [active] 714962005026 putative substrate binding site [chemical binding]; other site 714962005027 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 714962005028 putative GSH binding site [chemical binding]; other site 714962005029 catalytic residues [active] 714962005030 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 714962005031 NlpC/P60 family; Region: NLPC_P60; pfam00877 714962005032 superoxide dismutase; Provisional; Region: PRK10543 714962005033 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 714962005034 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 714962005035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962005036 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714962005037 putative substrate translocation pore; other site 714962005038 hypothetical protein; Provisional; Region: PRK14756 714962005039 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 714962005040 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714962005041 DNA binding site [nucleotide binding] 714962005042 domain linker motif; other site 714962005043 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 714962005044 dimerization interface [polypeptide binding]; other site 714962005045 ligand binding site [chemical binding]; other site 714962005046 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 714962005047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962005048 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714962005049 dimerization interface [polypeptide binding]; other site 714962005050 putative transporter; Provisional; Region: PRK11043 714962005051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962005052 putative substrate translocation pore; other site 714962005053 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 714962005054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 714962005055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962005056 S-adenosylmethionine binding site [chemical binding]; other site 714962005057 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 714962005058 Lumazine binding domain; Region: Lum_binding; pfam00677 714962005059 Lumazine binding domain; Region: Lum_binding; pfam00677 714962005060 multidrug efflux protein; Reviewed; Region: PRK01766 714962005061 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 714962005062 cation binding site [ion binding]; other site 714962005063 hypothetical protein; Provisional; Region: PRK09945 714962005064 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 714962005065 putative monooxygenase; Provisional; Region: PRK11118 714962005066 hypothetical protein; Provisional; Region: PRK09897 714962005067 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 714962005068 hypothetical protein; Provisional; Region: PRK09946 714962005069 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 714962005070 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 714962005071 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 714962005072 hypothetical protein; Provisional; Region: PRK09947 714962005073 hypothetical protein; Provisional; Region: PRK09898 714962005074 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 714962005075 hypothetical protein; Provisional; Region: PRK10292 714962005076 pyruvate kinase; Provisional; Region: PRK09206 714962005077 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 714962005078 domain interfaces; other site 714962005079 active site 714962005080 murein lipoprotein; Provisional; Region: PRK15396 714962005081 L,D-transpeptidase; Provisional; Region: PRK10190 714962005082 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 714962005083 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 714962005084 cysteine desufuration protein SufE; Provisional; Region: PRK09296 714962005085 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 714962005086 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 714962005087 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714962005088 catalytic residue [active] 714962005089 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 714962005090 FeS assembly protein SufD; Region: sufD; TIGR01981 714962005091 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 714962005092 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 714962005093 Walker A/P-loop; other site 714962005094 ATP binding site [chemical binding]; other site 714962005095 Q-loop/lid; other site 714962005096 ABC transporter signature motif; other site 714962005097 Walker B; other site 714962005098 D-loop; other site 714962005099 H-loop/switch region; other site 714962005100 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 714962005101 putative ABC transporter; Region: ycf24; CHL00085 714962005102 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 714962005103 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 714962005104 CoenzymeA binding site [chemical binding]; other site 714962005105 subunit interaction site [polypeptide binding]; other site 714962005106 PHB binding site; other site 714962005107 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 714962005108 FAD binding domain; Region: FAD_binding_4; pfam01565 714962005109 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 714962005110 putative inner membrane protein; Provisional; Region: PRK10983 714962005111 Domain of unknown function DUF20; Region: UPF0118; pfam01594 714962005112 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 714962005113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962005114 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714962005115 putative substrate translocation pore; other site 714962005116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962005117 putative substrate translocation pore; other site 714962005118 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 714962005119 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 714962005120 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 714962005121 shikimate binding site; other site 714962005122 NAD(P) binding site [chemical binding]; other site 714962005123 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 714962005124 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 714962005125 active site 714962005126 catalytic residue [active] 714962005127 dimer interface [polypeptide binding]; other site 714962005128 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 714962005129 Coenzyme A transferase; Region: CoA_trans; smart00882 714962005130 Coenzyme A transferase; Region: CoA_trans; cl17247 714962005131 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 714962005132 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 714962005133 active site 714962005134 Cupin domain; Region: Cupin_2; pfam07883 714962005135 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 714962005136 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714962005137 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962005138 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 714962005139 Ligand binding site [chemical binding]; other site 714962005140 Electron transfer flavoprotein domain; Region: ETF; pfam01012 714962005141 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 714962005142 Electron transfer flavoprotein domain; Region: ETF; smart00893 714962005143 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 714962005144 oxidoreductase; Provisional; Region: PRK10015 714962005145 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 714962005146 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 714962005147 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 714962005148 acyl-activating enzyme (AAE) consensus motif; other site 714962005149 putative AMP binding site [chemical binding]; other site 714962005150 putative active site [active] 714962005151 putative CoA binding site [chemical binding]; other site 714962005152 phosphoenolpyruvate synthase; Validated; Region: PRK06464 714962005153 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 714962005154 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 714962005155 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 714962005156 PEP synthetase regulatory protein; Provisional; Region: PRK05339 714962005157 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 714962005158 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 714962005159 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 714962005160 Uncharacterized conserved protein [Function unknown]; Region: COG0397 714962005161 hypothetical protein; Validated; Region: PRK00029 714962005162 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 714962005163 NlpC/P60 family; Region: NLPC_P60; pfam00877 714962005164 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 714962005165 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 714962005166 Walker A/P-loop; other site 714962005167 ATP binding site [chemical binding]; other site 714962005168 Q-loop/lid; other site 714962005169 ABC transporter signature motif; other site 714962005170 Walker B; other site 714962005171 D-loop; other site 714962005172 H-loop/switch region; other site 714962005173 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 714962005174 catalytic residues [active] 714962005175 dimer interface [polypeptide binding]; other site 714962005176 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 714962005177 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714962005178 ABC-ATPase subunit interface; other site 714962005179 dimer interface [polypeptide binding]; other site 714962005180 putative PBP binding regions; other site 714962005181 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 714962005182 IHF dimer interface [polypeptide binding]; other site 714962005183 IHF - DNA interface [nucleotide binding]; other site 714962005184 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 714962005185 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 714962005186 putative tRNA-binding site [nucleotide binding]; other site 714962005187 B3/4 domain; Region: B3_4; pfam03483 714962005188 tRNA synthetase B5 domain; Region: B5; smart00874 714962005189 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 714962005190 dimer interface [polypeptide binding]; other site 714962005191 motif 1; other site 714962005192 motif 3; other site 714962005193 motif 2; other site 714962005194 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 714962005195 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 714962005196 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 714962005197 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 714962005198 dimer interface [polypeptide binding]; other site 714962005199 motif 1; other site 714962005200 active site 714962005201 motif 2; other site 714962005202 motif 3; other site 714962005203 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 714962005204 23S rRNA binding site [nucleotide binding]; other site 714962005205 L21 binding site [polypeptide binding]; other site 714962005206 L13 binding site [polypeptide binding]; other site 714962005207 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 714962005208 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 714962005209 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 714962005210 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 714962005211 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 714962005212 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 714962005213 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 714962005214 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 714962005215 active site 714962005216 dimer interface [polypeptide binding]; other site 714962005217 motif 1; other site 714962005218 motif 2; other site 714962005219 motif 3; other site 714962005220 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 714962005221 anticodon binding site; other site 714962005222 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 714962005223 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 714962005224 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 714962005225 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 714962005226 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 714962005227 6-phosphofructokinase 2; Provisional; Region: PRK10294 714962005228 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 714962005229 putative substrate binding site [chemical binding]; other site 714962005230 putative ATP binding site [chemical binding]; other site 714962005231 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 714962005232 Phosphotransferase enzyme family; Region: APH; pfam01636 714962005233 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 714962005234 active site 714962005235 ATP binding site [chemical binding]; other site 714962005236 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 714962005237 YniB-like protein; Region: YniB; pfam14002 714962005238 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 714962005239 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 714962005240 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962005241 motif II; other site 714962005242 inner membrane protein; Provisional; Region: PRK11648 714962005243 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 714962005244 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 714962005245 cell division modulator; Provisional; Region: PRK10113 714962005246 hydroperoxidase II; Provisional; Region: katE; PRK11249 714962005247 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 714962005248 tetramer interface [polypeptide binding]; other site 714962005249 heme binding pocket [chemical binding]; other site 714962005250 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 714962005251 domain interactions; other site 714962005252 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 714962005253 putative active site [active] 714962005254 YdjC motif; other site 714962005255 Mg binding site [ion binding]; other site 714962005256 putative homodimer interface [polypeptide binding]; other site 714962005257 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 714962005258 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 714962005259 NAD binding site [chemical binding]; other site 714962005260 sugar binding site [chemical binding]; other site 714962005261 divalent metal binding site [ion binding]; other site 714962005262 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714962005263 dimer interface [polypeptide binding]; other site 714962005264 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 714962005265 Cupin domain; Region: Cupin_2; pfam07883 714962005266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962005267 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 714962005268 methionine cluster; other site 714962005269 active site 714962005270 phosphorylation site [posttranslational modification] 714962005271 metal binding site [ion binding]; metal-binding site 714962005272 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 714962005273 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 714962005274 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 714962005275 active site 714962005276 P-loop; other site 714962005277 phosphorylation site [posttranslational modification] 714962005278 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 714962005279 NAD+ synthetase; Region: nadE; TIGR00552 714962005280 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 714962005281 homodimer interface [polypeptide binding]; other site 714962005282 NAD binding pocket [chemical binding]; other site 714962005283 ATP binding pocket [chemical binding]; other site 714962005284 Mg binding site [ion binding]; other site 714962005285 active-site loop [active] 714962005286 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 714962005287 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 714962005288 GIY-YIG motif/motif A; other site 714962005289 active site 714962005290 catalytic site [active] 714962005291 putative DNA binding site [nucleotide binding]; other site 714962005292 metal binding site [ion binding]; metal-binding site 714962005293 hypothetical protein; Provisional; Region: PRK11396 714962005294 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 714962005295 dimer interface [polypeptide binding]; other site 714962005296 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 714962005297 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 714962005298 putative active site [active] 714962005299 Zn binding site [ion binding]; other site 714962005300 succinylarginine dihydrolase; Provisional; Region: PRK13281 714962005301 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 714962005302 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 714962005303 NAD(P) binding site [chemical binding]; other site 714962005304 catalytic residues [active] 714962005305 arginine succinyltransferase; Provisional; Region: PRK10456 714962005306 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 714962005307 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 714962005308 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714962005309 inhibitor-cofactor binding pocket; inhibition site 714962005310 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962005311 catalytic residue [active] 714962005312 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 714962005313 putative catalytic site [active] 714962005314 putative phosphate binding site [ion binding]; other site 714962005315 active site 714962005316 metal binding site A [ion binding]; metal-binding site 714962005317 DNA binding site [nucleotide binding] 714962005318 putative AP binding site [nucleotide binding]; other site 714962005319 putative metal binding site B [ion binding]; other site 714962005320 Uncharacterized conserved protein [Function unknown]; Region: COG0398 714962005321 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 714962005322 Uncharacterized conserved protein [Function unknown]; Region: COG0398 714962005323 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 714962005324 Uncharacterized conserved protein [Function unknown]; Region: COG2128 714962005325 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 714962005326 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 714962005327 hypothetical protein; Provisional; Region: PRK11622 714962005328 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 714962005329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962005330 dimer interface [polypeptide binding]; other site 714962005331 conserved gate region; other site 714962005332 putative PBP binding loops; other site 714962005333 ABC-ATPase subunit interface; other site 714962005334 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 714962005335 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962005336 Walker A/P-loop; other site 714962005337 ATP binding site [chemical binding]; other site 714962005338 Q-loop/lid; other site 714962005339 ABC transporter signature motif; other site 714962005340 Walker B; other site 714962005341 D-loop; other site 714962005342 H-loop/switch region; other site 714962005343 Rhodanese Homology Domain; Region: RHOD; smart00450 714962005344 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 714962005345 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 714962005346 active site residue [active] 714962005347 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 714962005348 active site residue [active] 714962005349 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 714962005350 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 714962005351 active site 714962005352 8-oxo-dGMP binding site [chemical binding]; other site 714962005353 nudix motif; other site 714962005354 metal binding site [ion binding]; metal-binding site 714962005355 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 714962005356 glutamate dehydrogenase; Provisional; Region: PRK09414 714962005357 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 714962005358 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 714962005359 NAD(P) binding site [chemical binding]; other site 714962005360 DNA topoisomerase III; Provisional; Region: PRK07726 714962005361 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 714962005362 active site 714962005363 putative interdomain interaction site [polypeptide binding]; other site 714962005364 putative metal-binding site [ion binding]; other site 714962005365 putative nucleotide binding site [chemical binding]; other site 714962005366 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 714962005367 domain I; other site 714962005368 DNA binding groove [nucleotide binding] 714962005369 phosphate binding site [ion binding]; other site 714962005370 domain II; other site 714962005371 domain III; other site 714962005372 nucleotide binding site [chemical binding]; other site 714962005373 catalytic site [active] 714962005374 domain IV; other site 714962005375 selenophosphate synthetase; Provisional; Region: PRK00943 714962005376 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 714962005377 dimerization interface [polypeptide binding]; other site 714962005378 putative ATP binding site [chemical binding]; other site 714962005379 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 714962005380 putative FMN binding site [chemical binding]; other site 714962005381 protease 4; Provisional; Region: PRK10949 714962005382 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 714962005383 tandem repeat interface [polypeptide binding]; other site 714962005384 oligomer interface [polypeptide binding]; other site 714962005385 active site residues [active] 714962005386 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 714962005387 tandem repeat interface [polypeptide binding]; other site 714962005388 oligomer interface [polypeptide binding]; other site 714962005389 active site residues [active] 714962005390 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 714962005391 active site 714962005392 homodimer interface [polypeptide binding]; other site 714962005393 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 714962005394 Isochorismatase family; Region: Isochorismatase; pfam00857 714962005395 catalytic triad [active] 714962005396 metal binding site [ion binding]; metal-binding site 714962005397 conserved cis-peptide bond; other site 714962005398 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 714962005399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962005400 putative substrate translocation pore; other site 714962005401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962005402 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 714962005403 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 714962005404 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 714962005405 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714962005406 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714962005407 active site 714962005408 catalytic tetrad [active] 714962005409 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 714962005410 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 714962005411 substrate binding site [chemical binding]; other site 714962005412 ATP binding site [chemical binding]; other site 714962005413 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 714962005414 intersubunit interface [polypeptide binding]; other site 714962005415 active site 714962005416 zinc binding site [ion binding]; other site 714962005417 Na+ binding site [ion binding]; other site 714962005418 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 714962005419 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 714962005420 inhibitor binding site; inhibition site 714962005421 catalytic Zn binding site [ion binding]; other site 714962005422 structural Zn binding site [ion binding]; other site 714962005423 NADP binding site [chemical binding]; other site 714962005424 tetramer interface [polypeptide binding]; other site 714962005425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962005426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962005427 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 714962005428 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 714962005429 putative NAD(P) binding site [chemical binding]; other site 714962005430 catalytic Zn binding site [ion binding]; other site 714962005431 structural Zn binding site [ion binding]; other site 714962005432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 714962005433 methionine sulfoxide reductase B; Provisional; Region: PRK00222 714962005434 SelR domain; Region: SelR; pfam01641 714962005435 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 714962005436 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 714962005437 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 714962005438 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 714962005439 active site 714962005440 phosphate binding residues; other site 714962005441 catalytic residues [active] 714962005442 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714962005443 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714962005444 active site 714962005445 catalytic tetrad [active] 714962005446 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 714962005447 PrkA family serine protein kinase; Provisional; Region: PRK15455 714962005448 AAA ATPase domain; Region: AAA_16; pfam13191 714962005449 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 714962005450 hypothetical protein; Provisional; Region: PRK05325 714962005451 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 714962005452 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714962005453 metal binding site [ion binding]; metal-binding site 714962005454 active site 714962005455 I-site; other site 714962005456 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 714962005457 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714962005458 metal binding site [ion binding]; metal-binding site 714962005459 active site 714962005460 I-site; other site 714962005461 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 714962005462 putative deacylase active site [active] 714962005463 Predicted membrane protein [Function unknown]; Region: COG2707 714962005464 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714962005465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962005466 cyanate transporter; Region: CynX; TIGR00896 714962005467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962005468 Uncharacterized conserved protein [Function unknown]; Region: COG3189 714962005469 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 714962005470 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 714962005471 Domain of unknown function (DUF333); Region: DUF333; pfam03891 714962005472 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 714962005473 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 714962005474 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 714962005475 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714962005476 metal binding site [ion binding]; metal-binding site 714962005477 active site 714962005478 I-site; other site 714962005479 hypothetical protein; Provisional; Region: PRK10457 714962005480 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 714962005481 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 714962005482 leucine export protein LeuE; Provisional; Region: PRK10958 714962005483 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714962005484 ribonuclease D; Provisional; Region: PRK10829 714962005485 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 714962005486 catalytic site [active] 714962005487 putative active site [active] 714962005488 putative substrate binding site [chemical binding]; other site 714962005489 Helicase and RNase D C-terminal; Region: HRDC; smart00341 714962005490 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 714962005491 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 714962005492 acyl-activating enzyme (AAE) consensus motif; other site 714962005493 putative AMP binding site [chemical binding]; other site 714962005494 putative active site [active] 714962005495 putative CoA binding site [chemical binding]; other site 714962005496 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 714962005497 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 714962005498 Glycoprotease family; Region: Peptidase_M22; pfam00814 714962005499 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 714962005500 DEAD/DEAH box helicase; Region: DEAD; pfam00270 714962005501 DEAD_2; Region: DEAD_2; pfam06733 714962005502 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 714962005503 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 714962005504 homotrimer interaction site [polypeptide binding]; other site 714962005505 putative active site [active] 714962005506 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 714962005507 hypothetical protein; Provisional; Region: PRK05114 714962005508 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 714962005509 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 714962005510 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 714962005511 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 714962005512 putative active site [active] 714962005513 putative CoA binding site [chemical binding]; other site 714962005514 nudix motif; other site 714962005515 metal binding site [ion binding]; metal-binding site 714962005516 L-serine deaminase; Provisional; Region: PRK15023 714962005517 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 714962005518 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 714962005519 phage resistance protein; Provisional; Region: PRK10551 714962005520 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 714962005521 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714962005522 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 714962005523 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 714962005524 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 714962005525 Transporter associated domain; Region: CorC_HlyC; smart01091 714962005526 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 714962005527 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 714962005528 active pocket/dimerization site; other site 714962005529 active site 714962005530 phosphorylation site [posttranslational modification] 714962005531 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 714962005532 active site 714962005533 phosphorylation site [posttranslational modification] 714962005534 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 714962005535 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 714962005536 Predicted membrane protein [Function unknown]; Region: COG4811 714962005537 hypothetical protein; Provisional; Region: PRK11469 714962005538 Domain of unknown function DUF; Region: DUF204; pfam02659 714962005539 Domain of unknown function DUF; Region: DUF204; pfam02659 714962005540 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 714962005541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962005542 S-adenosylmethionine binding site [chemical binding]; other site 714962005543 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 714962005544 DNA-binding site [nucleotide binding]; DNA binding site 714962005545 RNA-binding motif; other site 714962005546 YebO-like protein; Region: YebO; pfam13974 714962005547 PhoPQ regulatory protein; Provisional; Region: PRK10299 714962005548 YobH-like protein; Region: YobH; pfam13996 714962005549 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 714962005550 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714962005551 dimerization interface [polypeptide binding]; other site 714962005552 putative Zn2+ binding site [ion binding]; other site 714962005553 putative DNA binding site [nucleotide binding]; other site 714962005554 Bacterial transcriptional regulator; Region: IclR; pfam01614 714962005555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962005556 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714962005557 putative substrate translocation pore; other site 714962005558 Predicted integral membrane protein [Function unknown]; Region: COG5521 714962005559 heat shock protein HtpX; Provisional; Region: PRK05457 714962005560 carboxy-terminal protease; Provisional; Region: PRK11186 714962005561 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 714962005562 protein binding site [polypeptide binding]; other site 714962005563 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 714962005564 Catalytic dyad [active] 714962005565 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 714962005566 ProP expression regulator; Provisional; Region: PRK04950 714962005567 ProQ/FINO family; Region: ProQ; pfam04352 714962005568 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 714962005569 GAF domain; Region: GAF_2; pfam13185 714962005570 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 714962005571 Paraquat-inducible protein A; Region: PqiA; pfam04403 714962005572 Paraquat-inducible protein A; Region: PqiA; pfam04403 714962005573 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 714962005574 mce related protein; Region: MCE; pfam02470 714962005575 mce related protein; Region: MCE; pfam02470 714962005576 mce related protein; Region: MCE; pfam02470 714962005577 mce related protein; Region: MCE; pfam02470 714962005578 mce related protein; Region: MCE; pfam02470 714962005579 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 714962005580 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 714962005581 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 714962005582 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 714962005583 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 714962005584 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 714962005585 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714962005586 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 714962005587 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 714962005588 hypothetical protein; Provisional; Region: PRK10301 714962005589 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 714962005590 Predicted amidohydrolase [General function prediction only]; Region: COG0388 714962005591 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 714962005592 exodeoxyribonuclease X; Provisional; Region: PRK07983 714962005593 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 714962005594 active site 714962005595 catalytic site [active] 714962005596 substrate binding site [chemical binding]; other site 714962005597 protease 2; Provisional; Region: PRK10115 714962005598 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 714962005599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 714962005600 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 714962005601 putative metal binding site [ion binding]; other site 714962005602 hypothetical protein; Provisional; Region: PRK13680 714962005603 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 714962005604 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 714962005605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714962005606 ATP-grasp domain; Region: ATP-grasp; pfam02222 714962005607 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 714962005608 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 714962005609 active site 714962005610 intersubunit interface [polypeptide binding]; other site 714962005611 catalytic residue [active] 714962005612 phosphogluconate dehydratase; Validated; Region: PRK09054 714962005613 6-phosphogluconate dehydratase; Region: edd; TIGR01196 714962005614 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 714962005615 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 714962005616 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 714962005617 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 714962005618 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 714962005619 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 714962005620 putative active site [active] 714962005621 pyruvate kinase; Provisional; Region: PRK05826 714962005622 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 714962005623 domain interfaces; other site 714962005624 active site 714962005625 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 714962005626 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 714962005627 putative acyl-acceptor binding pocket; other site 714962005628 putative peptidase; Provisional; Region: PRK11649 714962005629 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 714962005630 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 714962005631 Peptidase family M23; Region: Peptidase_M23; pfam01551 714962005632 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 714962005633 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 714962005634 metal binding site [ion binding]; metal-binding site 714962005635 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 714962005636 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 714962005637 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 714962005638 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714962005639 ABC-ATPase subunit interface; other site 714962005640 dimer interface [polypeptide binding]; other site 714962005641 putative PBP binding regions; other site 714962005642 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 714962005643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962005644 Walker A motif; other site 714962005645 ATP binding site [chemical binding]; other site 714962005646 Walker B motif; other site 714962005647 arginine finger; other site 714962005648 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 714962005649 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 714962005650 RuvA N terminal domain; Region: RuvA_N; pfam01330 714962005651 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 714962005652 hypothetical protein; Provisional; Region: PRK11470 714962005653 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 714962005654 active site 714962005655 putative DNA-binding cleft [nucleotide binding]; other site 714962005656 dimer interface [polypeptide binding]; other site 714962005657 hypothetical protein; Validated; Region: PRK00110 714962005658 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 714962005659 nudix motif; other site 714962005660 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 714962005661 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 714962005662 dimer interface [polypeptide binding]; other site 714962005663 anticodon binding site; other site 714962005664 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 714962005665 homodimer interface [polypeptide binding]; other site 714962005666 motif 1; other site 714962005667 active site 714962005668 motif 2; other site 714962005669 GAD domain; Region: GAD; pfam02938 714962005670 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 714962005671 motif 3; other site 714962005672 Isochorismatase family; Region: Isochorismatase; pfam00857 714962005673 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 714962005674 catalytic triad [active] 714962005675 conserved cis-peptide bond; other site 714962005676 hypothetical protein; Provisional; Region: PRK10302 714962005677 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 714962005678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962005679 S-adenosylmethionine binding site [chemical binding]; other site 714962005680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962005681 S-adenosylmethionine binding site [chemical binding]; other site 714962005682 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 714962005683 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 714962005684 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 714962005685 molybdopterin cofactor binding site [chemical binding]; other site 714962005686 substrate binding site [chemical binding]; other site 714962005687 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 714962005688 molybdopterin cofactor binding site; other site 714962005689 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 714962005690 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 714962005691 copper homeostasis protein CutC; Provisional; Region: PRK11572 714962005692 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 714962005693 putative metal binding site [ion binding]; other site 714962005694 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 714962005695 arginyl-tRNA synthetase; Region: argS; TIGR00456 714962005696 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 714962005697 active site 714962005698 HIGH motif; other site 714962005699 KMSK motif region; other site 714962005700 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 714962005701 tRNA binding surface [nucleotide binding]; other site 714962005702 anticodon binding site; other site 714962005703 Flagellar protein FlhE; Region: FlhE; pfam06366 714962005704 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 714962005705 FHIPEP family; Region: FHIPEP; pfam00771 714962005706 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 714962005707 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 714962005708 chemotaxis regulator CheZ; Provisional; Region: PRK11166 714962005709 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 714962005710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962005711 active site 714962005712 phosphorylation site [posttranslational modification] 714962005713 intermolecular recognition site; other site 714962005714 dimerization interface [polypeptide binding]; other site 714962005715 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 714962005716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962005717 active site 714962005718 phosphorylation site [posttranslational modification] 714962005719 intermolecular recognition site; other site 714962005720 dimerization interface [polypeptide binding]; other site 714962005721 CheB methylesterase; Region: CheB_methylest; pfam01339 714962005722 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 714962005723 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 714962005724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962005725 S-adenosylmethionine binding site [chemical binding]; other site 714962005726 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 714962005727 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 714962005728 dimer interface [polypeptide binding]; other site 714962005729 ligand binding site [chemical binding]; other site 714962005730 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714962005731 dimerization interface [polypeptide binding]; other site 714962005732 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714962005733 dimer interface [polypeptide binding]; other site 714962005734 putative CheW interface [polypeptide binding]; other site 714962005735 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 714962005736 putative CheA interaction surface; other site 714962005737 chemotaxis protein CheA; Provisional; Region: PRK10547 714962005738 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 714962005739 putative binding surface; other site 714962005740 active site 714962005741 CheY binding; Region: CheY-binding; pfam09078 714962005742 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 714962005743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962005744 ATP binding site [chemical binding]; other site 714962005745 Mg2+ binding site [ion binding]; other site 714962005746 G-X-G motif; other site 714962005747 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 714962005748 flagellar motor protein MotB; Validated; Region: motB; PRK09041 714962005749 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 714962005750 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 714962005751 ligand binding site [chemical binding]; other site 714962005752 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 714962005753 flagellar motor protein MotA; Validated; Region: PRK09110 714962005754 transcriptional activator FlhC; Provisional; Region: PRK12722 714962005755 transcriptional activator FlhD; Provisional; Region: PRK02909 714962005756 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 714962005757 Ligand Binding Site [chemical binding]; other site 714962005758 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 714962005759 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 714962005760 active site 714962005761 homotetramer interface [polypeptide binding]; other site 714962005762 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 714962005763 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 714962005764 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 714962005765 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 714962005766 TM-ABC transporter signature motif; other site 714962005767 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 714962005768 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 714962005769 Walker A/P-loop; other site 714962005770 ATP binding site [chemical binding]; other site 714962005771 Q-loop/lid; other site 714962005772 ABC transporter signature motif; other site 714962005773 Walker B; other site 714962005774 D-loop; other site 714962005775 H-loop/switch region; other site 714962005776 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 714962005777 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 714962005778 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 714962005779 ligand binding site [chemical binding]; other site 714962005780 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 714962005781 Ferritin-like domain; Region: Ferritin; pfam00210 714962005782 ferroxidase diiron center [ion binding]; other site 714962005783 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 714962005784 YecR-like lipoprotein; Region: YecR; pfam13992 714962005785 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 714962005786 Ferritin-like domain; Region: Ferritin; pfam00210 714962005787 ferroxidase diiron center [ion binding]; other site 714962005788 probable metal-binding protein; Region: matur_matur; TIGR03853 714962005789 tyrosine transporter TyrP; Provisional; Region: PRK15132 714962005790 aromatic amino acid transport protein; Region: araaP; TIGR00837 714962005791 hypothetical protein; Provisional; Region: PRK10396 714962005792 yecA family protein; Region: ygfB_yecA; TIGR02292 714962005793 SEC-C motif; Region: SEC-C; pfam02810 714962005794 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 714962005795 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 714962005796 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 714962005797 GIY-YIG motif/motif A; other site 714962005798 active site 714962005799 catalytic site [active] 714962005800 putative DNA binding site [nucleotide binding]; other site 714962005801 metal binding site [ion binding]; metal-binding site 714962005802 UvrB/uvrC motif; Region: UVR; pfam02151 714962005803 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 714962005804 Helix-hairpin-helix motif; Region: HHH; pfam00633 714962005805 response regulator; Provisional; Region: PRK09483 714962005806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962005807 active site 714962005808 phosphorylation site [posttranslational modification] 714962005809 intermolecular recognition site; other site 714962005810 dimerization interface [polypeptide binding]; other site 714962005811 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714962005812 DNA binding residues [nucleotide binding] 714962005813 dimerization interface [polypeptide binding]; other site 714962005814 hypothetical protein; Provisional; Region: PRK10613 714962005815 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 714962005816 Autoinducer binding domain; Region: Autoind_bind; pfam03472 714962005817 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714962005818 DNA binding residues [nucleotide binding] 714962005819 dimerization interface [polypeptide binding]; other site 714962005820 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 714962005821 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 714962005822 Walker A/P-loop; other site 714962005823 ATP binding site [chemical binding]; other site 714962005824 Q-loop/lid; other site 714962005825 ABC transporter signature motif; other site 714962005826 Walker B; other site 714962005827 D-loop; other site 714962005828 H-loop/switch region; other site 714962005829 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 714962005830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962005831 dimer interface [polypeptide binding]; other site 714962005832 conserved gate region; other site 714962005833 putative PBP binding loops; other site 714962005834 ABC-ATPase subunit interface; other site 714962005835 D-cysteine desulfhydrase; Validated; Region: PRK03910 714962005836 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 714962005837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962005838 catalytic residue [active] 714962005839 cystine transporter subunit; Provisional; Region: PRK11260 714962005840 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714962005841 substrate binding pocket [chemical binding]; other site 714962005842 membrane-bound complex binding site; other site 714962005843 hinge residues; other site 714962005844 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 714962005845 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 714962005846 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714962005847 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 714962005848 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714962005849 DNA binding residues [nucleotide binding] 714962005850 flagellin; Validated; Region: PRK08026 714962005851 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 714962005852 Flagellin protein; Region: FliC; pfam12445 714962005853 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 714962005854 flagellar capping protein; Reviewed; Region: fliD; PRK08032 714962005855 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 714962005856 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 714962005857 Flagellar protein FliS; Region: FliS; cl00654 714962005858 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 714962005859 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 714962005860 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 714962005861 active site 714962005862 Na/Ca binding site [ion binding]; other site 714962005863 catalytic site [active] 714962005864 lipoprotein; Provisional; Region: PRK10397 714962005865 putative inner membrane protein; Provisional; Region: PRK11099 714962005866 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 714962005867 CPxP motif; other site 714962005868 hypothetical protein; Provisional; Region: PRK09951 714962005869 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 714962005870 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 714962005871 trimer interface [polypeptide binding]; other site 714962005872 eyelet of channel; other site 714962005873 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714962005874 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 714962005875 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 714962005876 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 714962005877 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 714962005878 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 714962005879 flagellar motor switch protein FliG; Region: fliG; TIGR00207 714962005880 FliG C-terminal domain; Region: FliG_C; pfam01706 714962005881 flagellar assembly protein H; Validated; Region: fliH; PRK05687 714962005882 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 714962005883 Flagellar assembly protein FliH; Region: FliH; pfam02108 714962005884 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 714962005885 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 714962005886 Walker A motif/ATP binding site; other site 714962005887 Walker B motif; other site 714962005888 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 714962005889 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 714962005890 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 714962005891 flagellar hook-length control protein; Provisional; Region: PRK10118 714962005892 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 714962005893 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 714962005894 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 714962005895 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 714962005896 flagellar motor switch protein; Validated; Region: fliN; PRK05698 714962005897 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 714962005898 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 714962005899 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 714962005900 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 714962005901 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 714962005902 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714962005903 DNA binding residues [nucleotide binding] 714962005904 dimerization interface [polypeptide binding]; other site 714962005905 hypothetical protein; Provisional; Region: PRK10708 714962005906 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 714962005907 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 714962005908 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962005909 active site 714962005910 motif I; other site 714962005911 motif II; other site 714962005912 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 714962005913 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714962005914 metal binding site [ion binding]; metal-binding site 714962005915 active site 714962005916 I-site; other site 714962005917 hypothetical protein; Provisional; Region: PRK10062 714962005918 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 714962005919 EamA-like transporter family; Region: EamA; pfam00892 714962005920 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 714962005921 additional DNA contacts [nucleotide binding]; other site 714962005922 mismatch recognition site; other site 714962005923 active site 714962005924 zinc binding site [ion binding]; other site 714962005925 DNA intercalation site [nucleotide binding]; other site 714962005926 DNA cytosine methylase; Provisional; Region: PRK10458 714962005927 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 714962005928 cofactor binding site; other site 714962005929 DNA binding site [nucleotide binding] 714962005930 substrate interaction site [chemical binding]; other site 714962005931 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 714962005932 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714962005933 Zn2+ binding site [ion binding]; other site 714962005934 Mg2+ binding site [ion binding]; other site 714962005935 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 714962005936 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 714962005937 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 714962005938 eyelet of channel; other site 714962005939 trimer interface [polypeptide binding]; other site 714962005940 chaperone protein HchA; Provisional; Region: PRK04155 714962005941 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 714962005942 dimer interface [polypeptide binding]; other site 714962005943 metal binding site [ion binding]; metal-binding site 714962005944 potential oxyanion hole; other site 714962005945 potential catalytic triad [active] 714962005946 conserved cys residue [active] 714962005947 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 714962005948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962005949 dimer interface [polypeptide binding]; other site 714962005950 phosphorylation site [posttranslational modification] 714962005951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962005952 ATP binding site [chemical binding]; other site 714962005953 Mg2+ binding site [ion binding]; other site 714962005954 G-X-G motif; other site 714962005955 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 714962005956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962005957 active site 714962005958 phosphorylation site [posttranslational modification] 714962005959 intermolecular recognition site; other site 714962005960 dimerization interface [polypeptide binding]; other site 714962005961 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714962005962 DNA binding site [nucleotide binding] 714962005963 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 714962005964 active site 714962005965 homotetramer interface [polypeptide binding]; other site 714962005966 TMAO/DMSO reductase; Reviewed; Region: PRK05363 714962005967 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 714962005968 Moco binding site; other site 714962005969 metal coordination site [ion binding]; other site 714962005970 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 714962005971 zinc/cadmium-binding protein; Provisional; Region: PRK10306 714962005972 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 714962005973 CdtB, the catalytic DNase I-like subunit of cytolethal distending toxin (CDT) protein; Region: CdtB; cd09081 714962005974 putative catalytic site [active] 714962005975 CdtC interface [polypeptide binding]; other site 714962005976 heterotrimer interface [polypeptide binding]; other site 714962005977 CdtA interface [polypeptide binding]; other site 714962005978 putative metal binding site [ion binding]; other site 714962005979 putative phosphate binding site [ion binding]; other site 714962005980 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 714962005981 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 714962005982 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 714962005983 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 714962005984 Phage-related protein, tail component [Function unknown]; Region: COG4733 714962005985 Putative phage tail protein; Region: Phage-tail_3; pfam13550 714962005986 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 714962005987 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 714962005988 Fibronectin type III protein; Region: DUF3672; pfam12421 714962005989 Phage-related protein, tail component [Function unknown]; Region: COG4723 714962005990 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 714962005991 MPN+ (JAMM) motif; other site 714962005992 Zinc-binding site [ion binding]; other site 714962005993 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 714962005994 NlpC/P60 family; Region: NLPC_P60; cl17555 714962005995 Phage-related protein [Function unknown]; Region: gp18; COG4672 714962005996 Phage minor tail protein; Region: Phage_min_tail; pfam05939 714962005997 Phage-related minor tail protein [Function unknown]; Region: COG5281 714962005998 tape measure domain; Region: tape_meas_nterm; TIGR02675 714962005999 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 714962006000 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 714962006001 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 714962006002 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 714962006003 Immunoglobulin domain; Region: Ig_2; pfam13895 714962006004 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 714962006005 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 714962006006 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 714962006007 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 714962006008 oligomerization interface [polypeptide binding]; other site 714962006009 Phage head maturation protease [General function prediction only]; Region: COG3740 714962006010 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 714962006011 Phage terminase, small subunit; Region: Terminase_4; pfam05119 714962006012 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 714962006013 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 714962006014 catalytic residues [active] 714962006015 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 714962006016 Lysis protein S; Region: Lysis_S; pfam04971 714962006017 Antitermination protein; Region: Antiterm; pfam03589 714962006018 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 714962006019 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 714962006020 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 714962006021 Protein of unknown function (DUF968); Region: DUF968; pfam06147 714962006022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 714962006023 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 714962006024 primosomal protein DnaI; Provisional; Region: PRK02854 714962006025 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 714962006026 transcriptional repressor DicA; Reviewed; Region: PRK09706 714962006027 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714962006028 non-specific DNA binding site [nucleotide binding]; other site 714962006029 salt bridge; other site 714962006030 sequence-specific DNA binding site [nucleotide binding]; other site 714962006031 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 714962006032 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 714962006033 active site 714962006034 substrate binding site [chemical binding]; other site 714962006035 catalytic site [active] 714962006036 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 714962006037 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 714962006038 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 714962006039 active site 714962006040 DNA binding site [nucleotide binding] 714962006041 Int/Topo IB signature motif; other site 714962006042 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 714962006043 muropeptide transporter; Validated; Region: ampG; cl17669 714962006044 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 714962006045 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962006046 Walker A/P-loop; other site 714962006047 ATP binding site [chemical binding]; other site 714962006048 Q-loop/lid; other site 714962006049 ABC transporter signature motif; other site 714962006050 Walker B; other site 714962006051 D-loop; other site 714962006052 H-loop/switch region; other site 714962006053 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 714962006054 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 714962006055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962006056 Walker A/P-loop; other site 714962006057 ATP binding site [chemical binding]; other site 714962006058 Q-loop/lid; other site 714962006059 ABC transporter signature motif; other site 714962006060 Walker B; other site 714962006061 D-loop; other site 714962006062 H-loop/switch region; other site 714962006063 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714962006064 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962006065 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 714962006066 Condensation domain; Region: Condensation; pfam00668 714962006067 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 714962006068 Nonribosomal peptide synthase; Region: NRPS; pfam08415 714962006069 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 714962006070 acyl-activating enzyme (AAE) consensus motif; other site 714962006071 AMP binding site [chemical binding]; other site 714962006072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962006073 S-adenosylmethionine binding site [chemical binding]; other site 714962006074 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 714962006075 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714962006076 Condensation domain; Region: Condensation; pfam00668 714962006077 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 714962006078 Nonribosomal peptide synthase; Region: NRPS; pfam08415 714962006079 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714962006080 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 714962006081 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 714962006082 active site 714962006083 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 714962006084 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 714962006085 Methyltransferase domain; Region: Methyltransf_12; pfam08242 714962006086 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 714962006087 KR domain; Region: KR; pfam08659 714962006088 NADP binding site [chemical binding]; other site 714962006089 active site 714962006090 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714962006091 Condensation domain; Region: Condensation; pfam00668 714962006092 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 714962006093 Nonribosomal peptide synthase; Region: NRPS; pfam08415 714962006094 Methyltransferase domain; Region: Methyltransf_12; pfam08242 714962006095 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714962006096 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 714962006097 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 714962006098 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 714962006099 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 714962006100 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 714962006101 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 714962006102 acyl-activating enzyme (AAE) consensus motif; other site 714962006103 active site 714962006104 AMP binding site [chemical binding]; other site 714962006105 substrate binding site [chemical binding]; other site 714962006106 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 714962006107 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 714962006108 N-terminal plug; other site 714962006109 ligand-binding site [chemical binding]; other site 714962006110 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 714962006111 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 714962006112 shikimate transporter; Provisional; Region: PRK09952 714962006113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962006114 putative substrate translocation pore; other site 714962006115 AMP nucleosidase; Provisional; Region: PRK08292 714962006116 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 714962006117 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 714962006118 hypothetical protein; Provisional; Region: PRK12378 714962006119 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 714962006120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962006121 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 714962006122 putative dimerization interface [polypeptide binding]; other site 714962006123 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 714962006124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962006125 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 714962006126 putative substrate binding site [chemical binding]; other site 714962006127 dimerization interface [polypeptide binding]; other site 714962006128 MATE family multidrug exporter; Provisional; Region: PRK10189 714962006129 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 714962006130 integrase; Provisional; Region: PRK09692 714962006131 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 714962006132 active site 714962006133 Int/Topo IB signature motif; other site 714962006134 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 714962006135 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 714962006136 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714962006137 Beta-lactamase; Region: Beta-lactamase; pfam00144 714962006138 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 714962006139 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 714962006140 active site 714962006141 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_6; cd13146 714962006142 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 714962006143 amidase; Provisional; Region: PRK06170 714962006144 Amidase; Region: Amidase; cl11426 714962006145 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 714962006146 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 714962006147 active site 714962006148 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714962006149 Condensation domain; Region: Condensation; pfam00668 714962006150 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 714962006151 Nonribosomal peptide synthase; Region: NRPS; pfam08415 714962006152 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 714962006153 acyl-activating enzyme (AAE) consensus motif; other site 714962006154 AMP binding site [chemical binding]; other site 714962006155 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 714962006156 putative FMN binding site [chemical binding]; other site 714962006157 NADPH bind site [chemical binding]; other site 714962006158 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 714962006159 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714962006160 Condensation domain; Region: Condensation; pfam00668 714962006161 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 714962006162 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 714962006163 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 714962006164 acyl-activating enzyme (AAE) consensus motif; other site 714962006165 AMP binding site [chemical binding]; other site 714962006166 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714962006167 Condensation domain; Region: Condensation; pfam00668 714962006168 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 714962006169 Nonribosomal peptide synthase; Region: NRPS; pfam08415 714962006170 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 714962006171 acyl-activating enzyme (AAE) consensus motif; other site 714962006172 AMP binding site [chemical binding]; other site 714962006173 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714962006174 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 714962006175 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 714962006176 active site 714962006177 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 714962006178 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 714962006179 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714962006180 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 714962006181 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 714962006182 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 714962006183 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 714962006184 active site 714962006185 acyl carrier protein; Provisional; Region: PRK07081 714962006186 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 714962006187 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 714962006188 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 714962006189 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 714962006190 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 714962006191 active site 714962006192 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714962006193 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 714962006194 DNA-binding interface [nucleotide binding]; DNA binding site 714962006195 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 714962006196 Integrase core domain; Region: rve; pfam00665 714962006197 Integrase core domain; Region: rve_3; pfam13683 714962006198 L,D-transpeptidase; Provisional; Region: PRK10190 714962006199 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 714962006200 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 714962006201 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 714962006202 putative dimer interface [polypeptide binding]; other site 714962006203 active site pocket [active] 714962006204 putative cataytic base [active] 714962006205 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 714962006206 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 714962006207 homotrimer interface [polypeptide binding]; other site 714962006208 Walker A motif; other site 714962006209 GTP binding site [chemical binding]; other site 714962006210 Walker B motif; other site 714962006211 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 714962006212 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 714962006213 N-terminal plug; other site 714962006214 ligand-binding site [chemical binding]; other site 714962006215 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 714962006216 ParB-like nuclease domain; Region: ParBc; cl02129 714962006217 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 714962006218 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 714962006219 Active Sites [active] 714962006220 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 714962006221 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 714962006222 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 714962006223 DXD motif; other site 714962006224 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 714962006225 putative trimer interface [polypeptide binding]; other site 714962006226 putative CoA binding site [chemical binding]; other site 714962006227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 714962006228 Transposase; Region: DEDD_Tnp_IS110; pfam01548 714962006229 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 714962006230 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 714962006231 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 714962006232 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 714962006233 active site 714962006234 substrate binding pocket [chemical binding]; other site 714962006235 homodimer interaction site [polypeptide binding]; other site 714962006236 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 714962006237 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 714962006238 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 714962006239 Transposase; Region: DEDD_Tnp_IS110; pfam01548 714962006240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 714962006241 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 714962006242 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 714962006243 transposase/IS protein; Provisional; Region: PRK09183 714962006244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962006245 Walker A motif; other site 714962006246 ATP binding site [chemical binding]; other site 714962006247 Walker B motif; other site 714962006248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 714962006249 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 714962006250 DNA-binding interface [nucleotide binding]; DNA binding site 714962006251 Integrase core domain; Region: rve; pfam00665 714962006252 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 714962006253 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 714962006254 Walker A/P-loop; other site 714962006255 ATP binding site [chemical binding]; other site 714962006256 Q-loop/lid; other site 714962006257 ABC transporter signature motif; other site 714962006258 Walker B; other site 714962006259 D-loop; other site 714962006260 H-loop/switch region; other site 714962006261 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714962006262 dimer interface [polypeptide binding]; other site 714962006263 putative PBP binding regions; other site 714962006264 ABC-ATPase subunit interface; other site 714962006265 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 714962006266 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 714962006267 putative ligand binding residues [chemical binding]; other site 714962006268 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 714962006269 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 714962006270 N-terminal plug; other site 714962006271 ligand-binding site [chemical binding]; other site 714962006272 hypothetical protein; Provisional; Region: PRK09866 714962006273 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 714962006274 G1 box; other site 714962006275 GTP/Mg2+ binding site [chemical binding]; other site 714962006276 G2 box; other site 714962006277 Switch I region; other site 714962006278 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 714962006279 G3 box; other site 714962006280 Switch II region; other site 714962006281 GTP/Mg2+ binding site [chemical binding]; other site 714962006282 G4 box; other site 714962006283 G5 box; other site 714962006284 YjcZ-like protein; Region: YjcZ; pfam13990 714962006285 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 714962006286 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 714962006287 nucleophile elbow; other site 714962006288 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 714962006289 Domain of unknown function (DUF932); Region: DUF932; pfam06067 714962006290 Antirestriction protein; Region: Antirestrict; pfam03230 714962006291 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 714962006292 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 714962006293 MPN+ (JAMM) motif; other site 714962006294 Zinc-binding site [ion binding]; other site 714962006295 Protein of unknown function (DUF987); Region: DUF987; pfam06174 714962006296 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 714962006297 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 714962006298 hypothetical protein; Provisional; Region: PRK05423 714962006299 Predicted membrane protein [Function unknown]; Region: COG1289 714962006300 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 714962006301 DNA gyrase inhibitor; Provisional; Region: PRK10016 714962006302 exonuclease I; Provisional; Region: sbcB; PRK11779 714962006303 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 714962006304 active site 714962006305 catalytic site [active] 714962006306 substrate binding site [chemical binding]; other site 714962006307 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 714962006308 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 714962006309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962006310 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 714962006311 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714962006312 dimerization interface [polypeptide binding]; other site 714962006313 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 714962006314 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 714962006315 putative NAD(P) binding site [chemical binding]; other site 714962006316 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 714962006317 antitoxin YefM; Provisional; Region: PRK11409 714962006318 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 714962006319 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 714962006320 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 714962006321 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 714962006322 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 714962006323 NAD binding site [chemical binding]; other site 714962006324 dimerization interface [polypeptide binding]; other site 714962006325 product binding site; other site 714962006326 substrate binding site [chemical binding]; other site 714962006327 zinc binding site [ion binding]; other site 714962006328 catalytic residues [active] 714962006329 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 714962006330 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714962006331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962006332 homodimer interface [polypeptide binding]; other site 714962006333 catalytic residue [active] 714962006334 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 714962006335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962006336 active site 714962006337 motif I; other site 714962006338 motif II; other site 714962006339 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 714962006340 putative active site pocket [active] 714962006341 4-fold oligomerization interface [polypeptide binding]; other site 714962006342 metal binding residues [ion binding]; metal-binding site 714962006343 3-fold/trimer interface [polypeptide binding]; other site 714962006344 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 714962006345 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 714962006346 putative active site [active] 714962006347 oxyanion strand; other site 714962006348 catalytic triad [active] 714962006349 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 714962006350 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 714962006351 catalytic residues [active] 714962006352 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 714962006353 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 714962006354 substrate binding site [chemical binding]; other site 714962006355 glutamase interaction surface [polypeptide binding]; other site 714962006356 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 714962006357 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 714962006358 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 714962006359 metal binding site [ion binding]; metal-binding site 714962006360 chain length determinant protein WzzB; Provisional; Region: PRK15471 714962006361 Chain length determinant protein; Region: Wzz; pfam02706 714962006362 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 714962006363 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 714962006364 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 714962006365 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 714962006366 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 714962006367 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 714962006368 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 714962006369 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 714962006370 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 714962006371 putative ADP-binding pocket [chemical binding]; other site 714962006372 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 714962006373 This family is most closely related to the GT1 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor...; Region: GT1_WbdM_like; cd04951 714962006374 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 714962006375 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 714962006376 active site 714962006377 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 714962006378 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 714962006379 Probable Catalytic site; other site 714962006380 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 714962006381 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 714962006382 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 714962006383 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 714962006384 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 714962006385 substrate binding site; other site 714962006386 tetramer interface; other site 714962006387 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 714962006388 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 714962006389 NADP binding site [chemical binding]; other site 714962006390 active site 714962006391 putative substrate binding site [chemical binding]; other site 714962006392 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 714962006393 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 714962006394 NAD binding site [chemical binding]; other site 714962006395 substrate binding site [chemical binding]; other site 714962006396 homodimer interface [polypeptide binding]; other site 714962006397 active site 714962006398 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 714962006399 active site 714962006400 tetramer interface; other site 714962006401 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 714962006402 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 714962006403 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 714962006404 putative ADP-binding pocket [chemical binding]; other site 714962006405 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 714962006406 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 714962006407 colanic acid exporter; Provisional; Region: PRK10459 714962006408 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 714962006409 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 714962006410 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 714962006411 phosphomannomutase CpsG; Provisional; Region: PRK15414 714962006412 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 714962006413 active site 714962006414 substrate binding site [chemical binding]; other site 714962006415 metal binding site [ion binding]; metal-binding site 714962006416 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 714962006417 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 714962006418 Substrate binding site; other site 714962006419 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 714962006420 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 714962006421 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 714962006422 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 714962006423 active site 714962006424 GDP-Mannose binding site [chemical binding]; other site 714962006425 dimer interface [polypeptide binding]; other site 714962006426 modified nudix motif 714962006427 metal binding site [ion binding]; metal-binding site 714962006428 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 714962006429 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 714962006430 NADP binding site [chemical binding]; other site 714962006431 active site 714962006432 putative substrate binding site [chemical binding]; other site 714962006433 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 714962006434 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 714962006435 NADP-binding site; other site 714962006436 homotetramer interface [polypeptide binding]; other site 714962006437 substrate binding site [chemical binding]; other site 714962006438 homodimer interface [polypeptide binding]; other site 714962006439 active site 714962006440 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 714962006441 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 714962006442 putative trimer interface [polypeptide binding]; other site 714962006443 putative active site [active] 714962006444 putative substrate binding site [chemical binding]; other site 714962006445 putative CoA binding site [chemical binding]; other site 714962006446 putative glycosyl transferase; Provisional; Region: PRK10063 714962006447 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 714962006448 metal-binding site 714962006449 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 714962006450 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 714962006451 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 714962006452 putative acyl transferase; Provisional; Region: PRK10191 714962006453 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 714962006454 trimer interface [polypeptide binding]; other site 714962006455 active site 714962006456 substrate binding site [chemical binding]; other site 714962006457 CoA binding site [chemical binding]; other site 714962006458 putative glycosyl transferase; Provisional; Region: PRK10018 714962006459 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 714962006460 active site 714962006461 tyrosine kinase; Provisional; Region: PRK11519 714962006462 Chain length determinant protein; Region: Wzz; pfam02706 714962006463 Chain length determinant protein; Region: Wzz; cl15801 714962006464 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 714962006465 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 714962006466 Low molecular weight phosphatase family; Region: LMWPc; cd00115 714962006467 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 714962006468 active site 714962006469 polysaccharide export protein Wza; Provisional; Region: PRK15078 714962006470 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 714962006471 SLBB domain; Region: SLBB; pfam10531 714962006472 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 714962006473 FOG: CBS domain [General function prediction only]; Region: COG0517 714962006474 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 714962006475 Transporter associated domain; Region: CorC_HlyC; smart01091 714962006476 Phage-related protein [Function unknown]; Region: COG4679 714962006477 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 714962006478 putative assembly protein; Provisional; Region: PRK10833 714962006479 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 714962006480 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 714962006481 trimer interface [polypeptide binding]; other site 714962006482 active site 714962006483 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 714962006484 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 714962006485 ATP-binding site [chemical binding]; other site 714962006486 Sugar specificity; other site 714962006487 Pyrimidine base specificity; other site 714962006488 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 714962006489 putative diguanylate cyclase; Provisional; Region: PRK09776 714962006490 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714962006491 putative active site [active] 714962006492 heme pocket [chemical binding]; other site 714962006493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714962006494 putative active site [active] 714962006495 heme pocket [chemical binding]; other site 714962006496 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714962006497 putative active site [active] 714962006498 heme pocket [chemical binding]; other site 714962006499 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714962006500 metal binding site [ion binding]; metal-binding site 714962006501 active site 714962006502 I-site; other site 714962006503 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 714962006504 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 714962006505 AlkA N-terminal domain; Region: AlkA_N; smart01009 714962006506 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 714962006507 minor groove reading motif; other site 714962006508 helix-hairpin-helix signature motif; other site 714962006509 substrate binding pocket [chemical binding]; other site 714962006510 active site 714962006511 putative chaperone; Provisional; Region: PRK11678 714962006512 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 714962006513 nucleotide binding site [chemical binding]; other site 714962006514 putative NEF/HSP70 interaction site [polypeptide binding]; other site 714962006515 SBD interface [polypeptide binding]; other site 714962006516 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 714962006517 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 714962006518 substrate binding site [chemical binding]; other site 714962006519 activation loop (A-loop); other site 714962006520 Y-family of DNA polymerases; Region: PolY; cl12025 714962006521 Protein phosphatase 2C; Region: PP2C_2; pfam13672 714962006522 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 714962006523 metal ion-dependent adhesion site (MIDAS); other site 714962006524 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 714962006525 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 714962006526 HlyD family secretion protein; Region: HlyD_3; pfam13437 714962006527 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 714962006528 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 714962006529 Protein export membrane protein; Region: SecD_SecF; cl14618 714962006530 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 714962006531 putative transporter; Provisional; Region: PRK10504 714962006532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962006533 putative substrate translocation pore; other site 714962006534 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 714962006535 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714962006536 dimerization interface [polypeptide binding]; other site 714962006537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962006538 dimer interface [polypeptide binding]; other site 714962006539 phosphorylation site [posttranslational modification] 714962006540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962006541 ATP binding site [chemical binding]; other site 714962006542 Mg2+ binding site [ion binding]; other site 714962006543 G-X-G motif; other site 714962006544 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 714962006545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962006546 active site 714962006547 phosphorylation site [posttranslational modification] 714962006548 intermolecular recognition site; other site 714962006549 dimerization interface [polypeptide binding]; other site 714962006550 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714962006551 DNA binding site [nucleotide binding] 714962006552 Uncharacterized conserved protein [Function unknown]; Region: COG3422 714962006553 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 714962006554 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 714962006555 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 714962006556 PcfJ-like protein; Region: PcfJ; pfam14284 714962006557 putative protease; Provisional; Region: PRK15452 714962006558 Peptidase family U32; Region: Peptidase_U32; pfam01136 714962006559 lipid kinase; Reviewed; Region: PRK13054 714962006560 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 714962006561 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 714962006562 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 714962006563 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 714962006564 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 714962006565 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 714962006566 putative NAD(P) binding site [chemical binding]; other site 714962006567 catalytic Zn binding site [ion binding]; other site 714962006568 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 714962006569 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 714962006570 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 714962006571 active site 714962006572 P-loop; other site 714962006573 phosphorylation site [posttranslational modification] 714962006574 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 714962006575 active site 714962006576 phosphorylation site [posttranslational modification] 714962006577 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 714962006578 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 714962006579 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 714962006580 intersubunit interface [polypeptide binding]; other site 714962006581 active site 714962006582 zinc binding site [ion binding]; other site 714962006583 Na+ binding site [ion binding]; other site 714962006584 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 714962006585 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 714962006586 putative active site; other site 714962006587 catalytic residue [active] 714962006588 nucleoside transporter; Region: 2A0110; TIGR00889 714962006589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962006590 putative substrate translocation pore; other site 714962006591 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 714962006592 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 714962006593 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 714962006594 substrate binding site [chemical binding]; other site 714962006595 ATP binding site [chemical binding]; other site 714962006596 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 714962006597 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962006598 DNA-binding site [nucleotide binding]; DNA binding site 714962006599 UTRA domain; Region: UTRA; pfam07702 714962006600 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 714962006601 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 714962006602 active site 714962006603 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 714962006604 dimer interface [polypeptide binding]; other site 714962006605 substrate binding site [chemical binding]; other site 714962006606 ATP binding site [chemical binding]; other site 714962006607 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 714962006608 substrate binding site [chemical binding]; other site 714962006609 multimerization interface [polypeptide binding]; other site 714962006610 ATP binding site [chemical binding]; other site 714962006611 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 714962006612 putative metal binding site [ion binding]; other site 714962006613 putative homodimer interface [polypeptide binding]; other site 714962006614 putative homotetramer interface [polypeptide binding]; other site 714962006615 putative homodimer-homodimer interface [polypeptide binding]; other site 714962006616 putative allosteric switch controlling residues; other site 714962006617 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 714962006618 Predicted integral membrane protein [Function unknown]; Region: COG5455 714962006619 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 714962006620 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 714962006621 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 714962006622 PapC N-terminal domain; Region: PapC_N; pfam13954 714962006623 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 714962006624 PapC C-terminal domain; Region: PapC_C; pfam13953 714962006625 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 714962006626 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 714962006627 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 714962006628 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 714962006629 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 714962006630 antiporter inner membrane protein; Provisional; Region: PRK11670 714962006631 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 714962006632 Walker A motif; other site 714962006633 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 714962006634 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 714962006635 active site 714962006636 HIGH motif; other site 714962006637 KMSKS motif; other site 714962006638 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 714962006639 tRNA binding surface [nucleotide binding]; other site 714962006640 anticodon binding site; other site 714962006641 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 714962006642 dimer interface [polypeptide binding]; other site 714962006643 putative tRNA-binding site [nucleotide binding]; other site 714962006644 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 714962006645 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 714962006646 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 714962006647 MoxR-like ATPases [General function prediction only]; Region: COG0714 714962006648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962006649 Walker A motif; other site 714962006650 ATP binding site [chemical binding]; other site 714962006651 Walker B motif; other site 714962006652 arginine finger; other site 714962006653 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 714962006654 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 714962006655 metal ion-dependent adhesion site (MIDAS); other site 714962006656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 714962006657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 714962006658 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 714962006659 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 714962006660 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 714962006661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962006662 active site 714962006663 phosphorylation site [posttranslational modification] 714962006664 intermolecular recognition site; other site 714962006665 dimerization interface [polypeptide binding]; other site 714962006666 LytTr DNA-binding domain; Region: LytTR; pfam04397 714962006667 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 714962006668 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 714962006669 GAF domain; Region: GAF; pfam01590 714962006670 Histidine kinase; Region: His_kinase; pfam06580 714962006671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962006672 ATP binding site [chemical binding]; other site 714962006673 Mg2+ binding site [ion binding]; other site 714962006674 G-X-G motif; other site 714962006675 transcriptional regulator MirA; Provisional; Region: PRK15043 714962006676 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 714962006677 DNA binding residues [nucleotide binding] 714962006678 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 714962006679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962006680 dimer interface [polypeptide binding]; other site 714962006681 conserved gate region; other site 714962006682 putative PBP binding loops; other site 714962006683 ABC-ATPase subunit interface; other site 714962006684 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 714962006685 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 714962006686 Walker A/P-loop; other site 714962006687 ATP binding site [chemical binding]; other site 714962006688 Q-loop/lid; other site 714962006689 ABC transporter signature motif; other site 714962006690 Walker B; other site 714962006691 D-loop; other site 714962006692 H-loop/switch region; other site 714962006693 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 714962006694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962006695 dimer interface [polypeptide binding]; other site 714962006696 conserved gate region; other site 714962006697 ABC-ATPase subunit interface; other site 714962006698 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 714962006699 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 714962006700 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 714962006701 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 714962006702 D-lactate dehydrogenase; Provisional; Region: PRK11183 714962006703 FAD binding domain; Region: FAD_binding_4; pfam01565 714962006704 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 714962006705 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 714962006706 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 714962006707 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 714962006708 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 714962006709 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 714962006710 oxidoreductase; Provisional; Region: PRK12743 714962006711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714962006712 NAD(P) binding site [chemical binding]; other site 714962006713 active site 714962006714 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 714962006715 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 714962006716 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 714962006717 FMN binding site [chemical binding]; other site 714962006718 active site 714962006719 catalytic residues [active] 714962006720 substrate binding site [chemical binding]; other site 714962006721 hypothetical protein; Provisional; Region: PRK01821 714962006722 hypothetical protein; Provisional; Region: PRK10711 714962006723 cytidine deaminase; Provisional; Region: PRK09027 714962006724 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 714962006725 active site 714962006726 catalytic motif [active] 714962006727 Zn binding site [ion binding]; other site 714962006728 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 714962006729 active site 714962006730 catalytic motif [active] 714962006731 Zn binding site [ion binding]; other site 714962006732 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 714962006733 putative active site [active] 714962006734 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 714962006735 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 714962006736 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 714962006737 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714962006738 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 714962006739 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 714962006740 homodimer interface [polypeptide binding]; other site 714962006741 active site 714962006742 FMN binding site [chemical binding]; other site 714962006743 substrate binding site [chemical binding]; other site 714962006744 4Fe-4S binding domain; Region: Fer4; pfam00037 714962006745 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 714962006746 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 714962006747 TM-ABC transporter signature motif; other site 714962006748 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 714962006749 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 714962006750 Walker A/P-loop; other site 714962006751 ATP binding site [chemical binding]; other site 714962006752 Q-loop/lid; other site 714962006753 ABC transporter signature motif; other site 714962006754 Walker B; other site 714962006755 D-loop; other site 714962006756 H-loop/switch region; other site 714962006757 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 714962006758 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 714962006759 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 714962006760 ligand binding site [chemical binding]; other site 714962006761 calcium binding site [ion binding]; other site 714962006762 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 714962006763 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714962006764 DNA binding site [nucleotide binding] 714962006765 domain linker motif; other site 714962006766 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 714962006767 dimerization interface (closed form) [polypeptide binding]; other site 714962006768 ligand binding site [chemical binding]; other site 714962006769 Predicted membrane protein [Function unknown]; Region: COG2311 714962006770 hypothetical protein; Provisional; Region: PRK10835 714962006771 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 714962006772 homodecamer interface [polypeptide binding]; other site 714962006773 GTP cyclohydrolase I; Provisional; Region: PLN03044 714962006774 active site 714962006775 putative catalytic site residues [active] 714962006776 zinc binding site [ion binding]; other site 714962006777 GTP-CH-I/GFRP interaction surface; other site 714962006778 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 714962006779 S-formylglutathione hydrolase; Region: PLN02442 714962006780 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 714962006781 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 714962006782 N-terminal plug; other site 714962006783 ligand-binding site [chemical binding]; other site 714962006784 lysine transporter; Provisional; Region: PRK10836 714962006785 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 714962006786 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962006787 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 714962006788 putative dimerization interface [polypeptide binding]; other site 714962006789 conserved hypothetical integral membrane protein; Region: TIGR00698 714962006790 endonuclease IV; Provisional; Region: PRK01060 714962006791 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 714962006792 AP (apurinic/apyrimidinic) site pocket; other site 714962006793 DNA interaction; other site 714962006794 Metal-binding active site; metal-binding site 714962006795 putative kinase; Provisional; Region: PRK09954 714962006796 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714962006797 putative DNA binding site [nucleotide binding]; other site 714962006798 putative Zn2+ binding site [ion binding]; other site 714962006799 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 714962006800 substrate binding site [chemical binding]; other site 714962006801 ATP binding site [chemical binding]; other site 714962006802 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 714962006803 active site 714962006804 tetramer interface [polypeptide binding]; other site 714962006805 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 714962006806 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 714962006807 ligand binding site [chemical binding]; other site 714962006808 flexible hinge region; other site 714962006809 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 714962006810 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 714962006811 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 714962006812 Nucleoside recognition; Region: Gate; pfam07670 714962006813 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 714962006814 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 714962006815 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 714962006816 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 714962006817 substrate binding site [chemical binding]; other site 714962006818 ATP binding site [chemical binding]; other site 714962006819 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 714962006820 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 714962006821 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 714962006822 active site 714962006823 P-loop; other site 714962006824 phosphorylation site [posttranslational modification] 714962006825 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 714962006826 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 714962006827 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 714962006828 putative substrate binding site [chemical binding]; other site 714962006829 putative ATP binding site [chemical binding]; other site 714962006830 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 714962006831 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 714962006832 active site 714962006833 phosphorylation site [posttranslational modification] 714962006834 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 714962006835 dimerization domain swap beta strand [polypeptide binding]; other site 714962006836 regulatory protein interface [polypeptide binding]; other site 714962006837 active site 714962006838 regulatory phosphorylation site [posttranslational modification]; other site 714962006839 sugar efflux transporter B; Provisional; Region: PRK15011 714962006840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962006841 putative substrate translocation pore; other site 714962006842 Flagellin N-methylase; Region: FliB; pfam03692 714962006843 elongation factor P; Provisional; Region: PRK04542 714962006844 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 714962006845 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 714962006846 RNA binding site [nucleotide binding]; other site 714962006847 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 714962006848 RNA binding site [nucleotide binding]; other site 714962006849 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 714962006850 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 714962006851 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 714962006852 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 714962006853 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 714962006854 active site 714962006855 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 714962006856 NlpC/P60 family; Region: NLPC_P60; pfam00877 714962006857 phage resistance protein; Provisional; Region: PRK10551 714962006858 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 714962006859 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714962006860 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714962006861 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 714962006862 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 714962006863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962006864 dimer interface [polypeptide binding]; other site 714962006865 conserved gate region; other site 714962006866 putative PBP binding loops; other site 714962006867 ABC-ATPase subunit interface; other site 714962006868 microcin C ABC transporter permease; Provisional; Region: PRK15021 714962006869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962006870 dimer interface [polypeptide binding]; other site 714962006871 conserved gate region; other site 714962006872 ABC-ATPase subunit interface; other site 714962006873 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 714962006874 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714962006875 Walker A/P-loop; other site 714962006876 ATP binding site [chemical binding]; other site 714962006877 Q-loop/lid; other site 714962006878 ABC transporter signature motif; other site 714962006879 Walker B; other site 714962006880 D-loop; other site 714962006881 H-loop/switch region; other site 714962006882 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 714962006883 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714962006884 Walker A/P-loop; other site 714962006885 ATP binding site [chemical binding]; other site 714962006886 Q-loop/lid; other site 714962006887 ABC transporter signature motif; other site 714962006888 Walker B; other site 714962006889 D-loop; other site 714962006890 H-loop/switch region; other site 714962006891 hypothetical protein; Provisional; Region: PRK11835 714962006892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962006893 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 714962006894 putative substrate translocation pore; other site 714962006895 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 714962006896 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714962006897 RNA binding surface [nucleotide binding]; other site 714962006898 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 714962006899 active site 714962006900 uracil binding [chemical binding]; other site 714962006901 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 714962006902 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714962006903 ATP binding site [chemical binding]; other site 714962006904 putative Mg++ binding site [ion binding]; other site 714962006905 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714962006906 nucleotide binding region [chemical binding]; other site 714962006907 ATP-binding site [chemical binding]; other site 714962006908 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 714962006909 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 714962006910 5S rRNA interface [nucleotide binding]; other site 714962006911 CTC domain interface [polypeptide binding]; other site 714962006912 L16 interface [polypeptide binding]; other site 714962006913 Nucleoid-associated protein [General function prediction only]; Region: COG3081 714962006914 nucleoid-associated protein NdpA; Validated; Region: PRK00378 714962006915 hypothetical protein; Provisional; Region: PRK13689 714962006916 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 714962006917 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 714962006918 Sulfatase; Region: Sulfatase; pfam00884 714962006919 transcriptional regulator NarP; Provisional; Region: PRK10403 714962006920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962006921 active site 714962006922 phosphorylation site [posttranslational modification] 714962006923 intermolecular recognition site; other site 714962006924 dimerization interface [polypeptide binding]; other site 714962006925 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714962006926 DNA binding residues [nucleotide binding] 714962006927 dimerization interface [polypeptide binding]; other site 714962006928 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 714962006929 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 714962006930 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 714962006931 binding surface 714962006932 TPR motif; other site 714962006933 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 714962006934 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 714962006935 catalytic residues [active] 714962006936 central insert; other site 714962006937 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 714962006938 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 714962006939 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 714962006940 heme exporter protein CcmC; Region: ccmC; TIGR01191 714962006941 heme exporter protein CcmB; Region: ccmB; TIGR01190 714962006942 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 714962006943 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 714962006944 Walker A/P-loop; other site 714962006945 ATP binding site [chemical binding]; other site 714962006946 Q-loop/lid; other site 714962006947 ABC transporter signature motif; other site 714962006948 Walker B; other site 714962006949 D-loop; other site 714962006950 H-loop/switch region; other site 714962006951 cytochrome c-type protein NapC; Provisional; Region: PRK10617 714962006952 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 714962006953 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 714962006954 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 714962006955 4Fe-4S binding domain; Region: Fer4_5; pfam12801 714962006956 4Fe-4S binding domain; Region: Fer4_6; pfam12837 714962006957 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 714962006958 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 714962006959 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 714962006960 [4Fe-4S] binding site [ion binding]; other site 714962006961 molybdopterin cofactor binding site; other site 714962006962 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 714962006963 molybdopterin cofactor binding site; other site 714962006964 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 714962006965 ferredoxin-type protein; Provisional; Region: PRK10194 714962006966 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 714962006967 secondary substrate binding site; other site 714962006968 primary substrate binding site; other site 714962006969 inhibition loop; other site 714962006970 dimerization interface [polypeptide binding]; other site 714962006971 malate:quinone oxidoreductase; Validated; Region: PRK05257 714962006972 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 714962006973 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 714962006974 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 714962006975 Walker A/P-loop; other site 714962006976 ATP binding site [chemical binding]; other site 714962006977 Q-loop/lid; other site 714962006978 ABC transporter signature motif; other site 714962006979 Walker B; other site 714962006980 D-loop; other site 714962006981 H-loop/switch region; other site 714962006982 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 714962006983 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 714962006984 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 714962006985 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962006986 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 714962006987 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 714962006988 DNA binding site [nucleotide binding] 714962006989 active site 714962006990 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 714962006991 ApbE family; Region: ApbE; pfam02424 714962006992 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 714962006993 outer membrane porin protein C; Provisional; Region: PRK10554 714962006994 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 714962006995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962006996 ATP binding site [chemical binding]; other site 714962006997 G-X-G motif; other site 714962006998 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 714962006999 putative binding surface; other site 714962007000 active site 714962007001 transcriptional regulator RcsB; Provisional; Region: PRK10840 714962007002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962007003 active site 714962007004 phosphorylation site [posttranslational modification] 714962007005 intermolecular recognition site; other site 714962007006 dimerization interface [polypeptide binding]; other site 714962007007 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714962007008 DNA binding residues [nucleotide binding] 714962007009 dimerization interface [polypeptide binding]; other site 714962007010 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 714962007011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962007012 dimer interface [polypeptide binding]; other site 714962007013 phosphorylation site [posttranslational modification] 714962007014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962007015 ATP binding site [chemical binding]; other site 714962007016 Mg2+ binding site [ion binding]; other site 714962007017 G-X-G motif; other site 714962007018 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 714962007019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962007020 active site 714962007021 phosphorylation site [posttranslational modification] 714962007022 intermolecular recognition site; other site 714962007023 dimerization interface [polypeptide binding]; other site 714962007024 sensory histidine kinase AtoS; Provisional; Region: PRK11360 714962007025 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714962007026 putative active site [active] 714962007027 heme pocket [chemical binding]; other site 714962007028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962007029 dimer interface [polypeptide binding]; other site 714962007030 phosphorylation site [posttranslational modification] 714962007031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962007032 ATP binding site [chemical binding]; other site 714962007033 Mg2+ binding site [ion binding]; other site 714962007034 G-X-G motif; other site 714962007035 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 714962007036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962007037 active site 714962007038 phosphorylation site [posttranslational modification] 714962007039 intermolecular recognition site; other site 714962007040 dimerization interface [polypeptide binding]; other site 714962007041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962007042 Walker A motif; other site 714962007043 ATP binding site [chemical binding]; other site 714962007044 Walker B motif; other site 714962007045 arginine finger; other site 714962007046 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 714962007047 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 714962007048 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 714962007049 putative acyltransferase; Provisional; Region: PRK05790 714962007050 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 714962007051 dimer interface [polypeptide binding]; other site 714962007052 active site 714962007053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 714962007054 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 714962007055 Predicted secreted protein [Function unknown]; Region: COG5445 714962007056 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 714962007057 Predicted secreted protein [Function unknown]; Region: COG5445 714962007058 Stage II sporulation protein; Region: SpoIID; pfam08486 714962007059 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 714962007060 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 714962007061 MG2 domain; Region: A2M_N; pfam01835 714962007062 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 714962007063 Alpha-2-macroglobulin family; Region: A2M; pfam00207 714962007064 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 714962007065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 714962007066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 714962007067 DNA gyrase subunit A; Validated; Region: PRK05560 714962007068 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 714962007069 CAP-like domain; other site 714962007070 active site 714962007071 primary dimer interface [polypeptide binding]; other site 714962007072 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714962007073 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714962007074 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714962007075 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714962007076 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714962007077 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714962007078 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 714962007079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962007080 S-adenosylmethionine binding site [chemical binding]; other site 714962007081 adhesin; Provisional; Region: PRK09752 714962007082 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 714962007083 Autotransporter beta-domain; Region: Autotransporter; pfam03797 714962007084 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 714962007085 ATP cone domain; Region: ATP-cone; pfam03477 714962007086 Class I ribonucleotide reductase; Region: RNR_I; cd01679 714962007087 active site 714962007088 dimer interface [polypeptide binding]; other site 714962007089 catalytic residues [active] 714962007090 effector binding site; other site 714962007091 R2 peptide binding site; other site 714962007092 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 714962007093 dimer interface [polypeptide binding]; other site 714962007094 putative radical transfer pathway; other site 714962007095 diiron center [ion binding]; other site 714962007096 tyrosyl radical; other site 714962007097 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 714962007098 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 714962007099 catalytic loop [active] 714962007100 iron binding site [ion binding]; other site 714962007101 hypothetical protein; Provisional; Region: PRK09902 714962007102 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 714962007103 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 714962007104 active site 714962007105 catalytic site [active] 714962007106 metal binding site [ion binding]; metal-binding site 714962007107 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 714962007108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962007109 putative substrate translocation pore; other site 714962007110 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 714962007111 hydroxyglutarate oxidase; Provisional; Region: PRK11728 714962007112 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 714962007113 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 714962007114 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 714962007115 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 714962007116 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 714962007117 Cysteine-rich domain; Region: CCG; pfam02754 714962007118 Cysteine-rich domain; Region: CCG; pfam02754 714962007119 hypothetical protein; Provisional; Region: PRK09956 714962007120 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 714962007121 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 714962007122 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 714962007123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962007124 putative substrate translocation pore; other site 714962007125 L-rhamnonate dehydratase; Provisional; Region: PRK15440 714962007126 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 714962007127 putative active site pocket [active] 714962007128 putative metal binding site [ion binding]; other site 714962007129 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 714962007130 Transcriptional regulator [Transcription]; Region: IclR; COG1414 714962007131 Bacterial transcriptional regulator; Region: IclR; pfam01614 714962007132 hypothetical protein; Provisional; Region: PRK03673 714962007133 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 714962007134 putative MPT binding site; other site 714962007135 Competence-damaged protein; Region: CinA; cl00666 714962007136 YfaZ precursor; Region: YfaZ; pfam07437 714962007137 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 714962007138 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 714962007139 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 714962007140 catalytic core [active] 714962007141 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 714962007142 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 714962007143 inhibitor-cofactor binding pocket; inhibition site 714962007144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962007145 catalytic residue [active] 714962007146 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 714962007147 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 714962007148 Ligand binding site; other site 714962007149 Putative Catalytic site; other site 714962007150 DXD motif; other site 714962007151 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 714962007152 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 714962007153 substrate binding site [chemical binding]; other site 714962007154 cosubstrate binding site; other site 714962007155 catalytic site [active] 714962007156 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 714962007157 active site 714962007158 hexamer interface [polypeptide binding]; other site 714962007159 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 714962007160 NAD binding site [chemical binding]; other site 714962007161 substrate binding site [chemical binding]; other site 714962007162 active site 714962007163 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 714962007164 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 714962007165 putative active site [active] 714962007166 putative catalytic site [active] 714962007167 putative Zn binding site [ion binding]; other site 714962007168 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 714962007169 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 714962007170 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 714962007171 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 714962007172 signal transduction protein PmrD; Provisional; Region: PRK15450 714962007173 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 714962007174 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 714962007175 acyl-activating enzyme (AAE) consensus motif; other site 714962007176 putative AMP binding site [chemical binding]; other site 714962007177 putative active site [active] 714962007178 putative CoA binding site [chemical binding]; other site 714962007179 O-succinylbenzoate synthase; Provisional; Region: PRK05105 714962007180 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 714962007181 active site 714962007182 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 714962007183 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 714962007184 substrate binding site [chemical binding]; other site 714962007185 oxyanion hole (OAH) forming residues; other site 714962007186 trimer interface [polypeptide binding]; other site 714962007187 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 714962007188 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 714962007189 catalytic site [active] 714962007190 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 714962007191 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 714962007192 dimer interface [polypeptide binding]; other site 714962007193 tetramer interface [polypeptide binding]; other site 714962007194 PYR/PP interface [polypeptide binding]; other site 714962007195 TPP binding site [chemical binding]; other site 714962007196 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 714962007197 TPP-binding site; other site 714962007198 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 714962007199 isochorismate synthases; Region: isochor_syn; TIGR00543 714962007200 hypothetical protein; Provisional; Region: PRK10404 714962007201 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714962007202 Coenzyme A binding pocket [chemical binding]; other site 714962007203 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714962007204 von Willebrand factor; Region: vWF_A; pfam12450 714962007205 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 714962007206 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 714962007207 metal ion-dependent adhesion site (MIDAS); other site 714962007208 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 714962007209 M28 Zn-Peptidases; Region: M28_like_1; cd05640 714962007210 Peptidase family M28; Region: Peptidase_M28; pfam04389 714962007211 metal binding site [ion binding]; metal-binding site 714962007212 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 714962007213 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 714962007214 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 714962007215 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 714962007216 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 714962007217 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 714962007218 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 714962007219 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 714962007220 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 714962007221 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 714962007222 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 714962007223 4Fe-4S binding domain; Region: Fer4; pfam00037 714962007224 4Fe-4S binding domain; Region: Fer4; pfam00037 714962007225 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 714962007226 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 714962007227 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 714962007228 catalytic loop [active] 714962007229 iron binding site [ion binding]; other site 714962007230 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 714962007231 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 714962007232 [4Fe-4S] binding site [ion binding]; other site 714962007233 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 714962007234 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 714962007235 SLBB domain; Region: SLBB; pfam10531 714962007236 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 714962007237 NADH dehydrogenase subunit E; Validated; Region: PRK07539 714962007238 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 714962007239 putative dimer interface [polypeptide binding]; other site 714962007240 [2Fe-2S] cluster binding site [ion binding]; other site 714962007241 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 714962007242 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 714962007243 NADH dehydrogenase subunit D; Validated; Region: PRK06075 714962007244 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 714962007245 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 714962007246 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 714962007247 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962007248 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 714962007249 putative dimerization interface [polypeptide binding]; other site 714962007250 aminotransferase AlaT; Validated; Region: PRK09265 714962007251 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714962007252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962007253 homodimer interface [polypeptide binding]; other site 714962007254 catalytic residue [active] 714962007255 5'-nucleotidase; Provisional; Region: PRK03826 714962007256 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 714962007257 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 714962007258 TrkA-C domain; Region: TrkA_C; pfam02080 714962007259 TrkA-C domain; Region: TrkA_C; pfam02080 714962007260 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 714962007261 putative phosphatase; Provisional; Region: PRK11587 714962007262 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962007263 motif II; other site 714962007264 hypothetical protein; Validated; Region: PRK05445 714962007265 hypothetical protein; Provisional; Region: PRK01816 714962007266 propionate/acetate kinase; Provisional; Region: PRK12379 714962007267 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 714962007268 phosphate acetyltransferase; Reviewed; Region: PRK05632 714962007269 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 714962007270 DRTGG domain; Region: DRTGG; pfam07085 714962007271 phosphate acetyltransferase; Region: pta; TIGR00651 714962007272 hypothetical protein; Provisional; Region: PRK11588 714962007273 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 714962007274 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 714962007275 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 714962007276 nudix motif; other site 714962007277 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 714962007278 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714962007279 active site 714962007280 metal binding site [ion binding]; metal-binding site 714962007281 homotetramer interface [polypeptide binding]; other site 714962007282 glutathione S-transferase; Provisional; Region: PRK15113 714962007283 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 714962007284 C-terminal domain interface [polypeptide binding]; other site 714962007285 GSH binding site (G-site) [chemical binding]; other site 714962007286 dimer interface [polypeptide binding]; other site 714962007287 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 714962007288 N-terminal domain interface [polypeptide binding]; other site 714962007289 putative dimer interface [polypeptide binding]; other site 714962007290 putative substrate binding pocket (H-site) [chemical binding]; other site 714962007291 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 714962007292 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 714962007293 C-terminal domain interface [polypeptide binding]; other site 714962007294 GSH binding site (G-site) [chemical binding]; other site 714962007295 dimer interface [polypeptide binding]; other site 714962007296 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 714962007297 N-terminal domain interface [polypeptide binding]; other site 714962007298 putative dimer interface [polypeptide binding]; other site 714962007299 active site 714962007300 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 714962007301 homooctamer interface [polypeptide binding]; other site 714962007302 active site 714962007303 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 714962007304 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 714962007305 putative NAD(P) binding site [chemical binding]; other site 714962007306 putative active site [active] 714962007307 putative transposase; Provisional; Region: PRK09857 714962007308 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 714962007309 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 714962007310 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 714962007311 Walker A/P-loop; other site 714962007312 ATP binding site [chemical binding]; other site 714962007313 Q-loop/lid; other site 714962007314 ABC transporter signature motif; other site 714962007315 Walker B; other site 714962007316 D-loop; other site 714962007317 H-loop/switch region; other site 714962007318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962007319 dimer interface [polypeptide binding]; other site 714962007320 conserved gate region; other site 714962007321 putative PBP binding loops; other site 714962007322 ABC-ATPase subunit interface; other site 714962007323 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 714962007324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962007325 dimer interface [polypeptide binding]; other site 714962007326 conserved gate region; other site 714962007327 putative PBP binding loops; other site 714962007328 ABC-ATPase subunit interface; other site 714962007329 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 714962007330 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714962007331 substrate binding pocket [chemical binding]; other site 714962007332 membrane-bound complex binding site; other site 714962007333 hinge residues; other site 714962007334 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 714962007335 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714962007336 substrate binding pocket [chemical binding]; other site 714962007337 membrane-bound complex binding site; other site 714962007338 hinge residues; other site 714962007339 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 714962007340 Flavoprotein; Region: Flavoprotein; pfam02441 714962007341 amidophosphoribosyltransferase; Provisional; Region: PRK09246 714962007342 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 714962007343 active site 714962007344 tetramer interface [polypeptide binding]; other site 714962007345 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714962007346 active site 714962007347 colicin V production protein; Provisional; Region: PRK10845 714962007348 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 714962007349 cell division protein DedD; Provisional; Region: PRK11633 714962007350 Sporulation related domain; Region: SPOR; pfam05036 714962007351 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 714962007352 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714962007353 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714962007354 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 714962007355 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 714962007356 hypothetical protein; Provisional; Region: PRK10847 714962007357 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 714962007358 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 714962007359 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 714962007360 dimerization interface 3.5A [polypeptide binding]; other site 714962007361 active site 714962007362 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 714962007363 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 714962007364 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 714962007365 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 714962007366 ligand binding site [chemical binding]; other site 714962007367 NAD binding site [chemical binding]; other site 714962007368 catalytic site [active] 714962007369 homodimer interface [polypeptide binding]; other site 714962007370 integrase; Provisional; Region: int; PHA02601 714962007371 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 714962007372 active site 714962007373 DNA binding site [nucleotide binding] 714962007374 Int/Topo IB signature motif; other site 714962007375 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 714962007376 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 714962007377 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 714962007378 Mg binding site [ion binding]; other site 714962007379 nucleotide binding site [chemical binding]; other site 714962007380 putative protofilament interface [polypeptide binding]; other site 714962007381 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 714962007382 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 714962007383 Phage-related protein [Function unknown]; Region: COG4695; cl01923 714962007384 Phage portal protein; Region: Phage_portal; pfam04860 714962007385 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 714962007386 terminase ATPase subunit; Provisional; Region: P; PHA02535 714962007387 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 714962007388 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 714962007389 terminase endonuclease subunit; Provisional; Region: M; PHA02537 714962007390 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 714962007391 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 714962007392 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 714962007393 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 714962007394 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 714962007395 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 714962007396 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 714962007397 Protein of unknown function (DUF2570); Region: DUF2570; pfam10828 714962007398 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 714962007399 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 714962007400 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 714962007401 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 714962007402 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 714962007403 Baseplate J-like protein; Region: Baseplate_J; cl01294 714962007404 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 714962007405 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 714962007406 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 714962007407 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 714962007408 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 714962007409 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 714962007410 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 714962007411 multiple promoter invertase; Provisional; Region: mpi; PRK13413 714962007412 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 714962007413 catalytic residues [active] 714962007414 catalytic nucleophile [active] 714962007415 Presynaptic Site I dimer interface [polypeptide binding]; other site 714962007416 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 714962007417 Synaptic Flat tetramer interface [polypeptide binding]; other site 714962007418 Synaptic Site I dimer interface [polypeptide binding]; other site 714962007419 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 714962007420 DNA-binding interface [nucleotide binding]; DNA binding site 714962007421 Phage protein U [General function prediction only]; Region: COG3499 714962007422 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 714962007423 Phage tail tube protein FII [General function prediction only]; Region: COG3498 714962007424 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 714962007425 tail protein; Provisional; Region: D; PHA02561 714962007426 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 714962007427 Double zinc ribbon; Region: DZR; pfam12773 714962007428 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 714962007429 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 714962007430 putative transporter; Provisional; Region: PRK12382 714962007431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962007432 putative substrate translocation pore; other site 714962007433 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 714962007434 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 714962007435 dimer interface [polypeptide binding]; other site 714962007436 active site 714962007437 Uncharacterized conserved protein [Function unknown]; Region: COG4121 714962007438 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 714962007439 YfcL protein; Region: YfcL; pfam08891 714962007440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 714962007441 hypothetical protein; Provisional; Region: PRK10621 714962007442 Predicted permeases [General function prediction only]; Region: COG0730 714962007443 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 714962007444 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 714962007445 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 714962007446 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 714962007447 Tetramer interface [polypeptide binding]; other site 714962007448 active site 714962007449 FMN-binding site [chemical binding]; other site 714962007450 HemK family putative methylases; Region: hemK_fam; TIGR00536 714962007451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962007452 S-adenosylmethionine binding site [chemical binding]; other site 714962007453 hypothetical protein; Provisional; Region: PRK04946 714962007454 Smr domain; Region: Smr; pfam01713 714962007455 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 714962007456 Fimbrial protein; Region: Fimbrial; cl01416 714962007457 Fimbrial protein; Region: Fimbrial; cl01416 714962007458 Fimbrial protein; Region: Fimbrial; cl01416 714962007459 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 714962007460 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 714962007461 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 714962007462 PapC N-terminal domain; Region: PapC_N; pfam13954 714962007463 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 714962007464 PapC C-terminal domain; Region: PapC_C; pfam13953 714962007465 Fimbrial protein; Region: Fimbrial; cl01416 714962007466 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714962007467 catalytic core [active] 714962007468 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 714962007469 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 714962007470 substrate binding site [chemical binding]; other site 714962007471 oxyanion hole (OAH) forming residues; other site 714962007472 trimer interface [polypeptide binding]; other site 714962007473 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 714962007474 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 714962007475 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 714962007476 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 714962007477 dimer interface [polypeptide binding]; other site 714962007478 active site 714962007479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 714962007480 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 714962007481 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 714962007482 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 714962007483 integrase; Provisional; Region: PRK09692 714962007484 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 714962007485 active site 714962007486 Int/Topo IB signature motif; other site 714962007487 Head binding; Region: Head_binding; pfam09008 714962007488 N terminal extension of bacteriophage endosialidase; Region: End_N_terminal; pfam12218 714962007489 Beta barrel domain of bacteriophage endosialidase; Region: End_beta_barrel; pfam12195 714962007490 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 714962007491 Asp-box motif; other site 714962007492 catalytic site [active] 714962007493 Catalytic domain of bacteriophage endosialidase; Region: End_tail_spike; pfam12219 714962007494 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 714962007495 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 714962007496 Prophage antirepressor [Transcription]; Region: COG3617 714962007497 Phage anti-repressor protein [Transcription]; Region: COG3561 714962007498 Mnt; Region: mnt; PHA01513 714962007499 Arc-like DNA binding domain; Region: Arc; pfam03869 714962007500 Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423 714962007501 Protein of unknown function (DUF2824); Region: DUF2824; pfam11039 714962007502 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 714962007503 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 714962007504 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 714962007505 Phage terminase large subunit; Region: Terminase_3; pfam04466 714962007506 Protein of unknown function (DUF2560); Region: DUF2560; pfam10834 714962007507 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 714962007508 ORF11CD3 domain; Region: ORF11CD3; pfam10549 714962007509 Lipoprotein Rz1 precursor; Region: Rz1; pfam06085 714962007510 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 714962007511 N-acetyl-D-glucosamine binding site [chemical binding]; other site 714962007512 catalytic residue [active] 714962007513 phage holin, lambda family; Region: holin_lambda; TIGR01594 714962007514 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 714962007515 Endodeoxyribonuclease RusA; Region: RusA; cl01885 714962007516 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 714962007517 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 714962007518 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 714962007519 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 714962007520 NinB protein; Region: NinB; pfam05772 714962007521 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 714962007522 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 714962007523 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 714962007524 Walker A motif; other site 714962007525 ATP binding site [chemical binding]; other site 714962007526 Walker B motif; other site 714962007527 DNA binding loops [nucleotide binding] 714962007528 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 714962007529 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 714962007530 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 714962007531 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714962007532 non-specific DNA binding site [nucleotide binding]; other site 714962007533 salt bridge; other site 714962007534 sequence-specific DNA binding site [nucleotide binding]; other site 714962007535 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 714962007536 Catalytic site [active] 714962007537 Antirestriction protein Ral; Region: Ral; pfam11058 714962007538 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 714962007539 ERF superfamily; Region: ERF; pfam04404 714962007540 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 714962007541 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 714962007542 Protein of unknown function (DUF551); Region: DUF551; pfam04448 714962007543 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 714962007544 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 714962007545 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 714962007546 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962007547 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 714962007548 dimerization interface [polypeptide binding]; other site 714962007549 substrate binding pocket [chemical binding]; other site 714962007550 permease DsdX; Provisional; Region: PRK09921 714962007551 gluconate transporter; Region: gntP; TIGR00791 714962007552 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 714962007553 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 714962007554 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714962007555 catalytic residue [active] 714962007556 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 714962007557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962007558 putative substrate translocation pore; other site 714962007559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962007560 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 714962007561 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 714962007562 HlyD family secretion protein; Region: HlyD_3; pfam13437 714962007563 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 714962007564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962007565 active site 714962007566 phosphorylation site [posttranslational modification] 714962007567 intermolecular recognition site; other site 714962007568 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714962007569 DNA binding residues [nucleotide binding] 714962007570 dimerization interface [polypeptide binding]; other site 714962007571 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 714962007572 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714962007573 substrate binding pocket [chemical binding]; other site 714962007574 membrane-bound complex binding site; other site 714962007575 hinge residues; other site 714962007576 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714962007577 substrate binding pocket [chemical binding]; other site 714962007578 membrane-bound complex binding site; other site 714962007579 hinge residues; other site 714962007580 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962007581 dimer interface [polypeptide binding]; other site 714962007582 phosphorylation site [posttranslational modification] 714962007583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962007584 ATP binding site [chemical binding]; other site 714962007585 Mg2+ binding site [ion binding]; other site 714962007586 G-X-G motif; other site 714962007587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962007588 active site 714962007589 phosphorylation site [posttranslational modification] 714962007590 intermolecular recognition site; other site 714962007591 dimerization interface [polypeptide binding]; other site 714962007592 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 714962007593 putative binding surface; other site 714962007594 active site 714962007595 putative CoA-transferase; Provisional; Region: PRK11430 714962007596 CoA-transferase family III; Region: CoA_transf_3; pfam02515 714962007597 putative transporter YfdV; Provisional; Region: PRK09903 714962007598 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 714962007599 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 714962007600 PYR/PP interface [polypeptide binding]; other site 714962007601 dimer interface [polypeptide binding]; other site 714962007602 TPP binding site [chemical binding]; other site 714962007603 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 714962007604 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 714962007605 TPP-binding site; other site 714962007606 dimer interface [polypeptide binding]; other site 714962007607 formyl-coenzyme A transferase; Provisional; Region: PRK05398 714962007608 CoA-transferase family III; Region: CoA_transf_3; pfam02515 714962007609 hypothetical protein; Provisional; Region: PRK10316 714962007610 YfdX protein; Region: YfdX; pfam10938 714962007611 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 714962007612 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 714962007613 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 714962007614 putative acyl-acceptor binding pocket; other site 714962007615 aminotransferase; Validated; Region: PRK08175 714962007616 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714962007617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962007618 homodimer interface [polypeptide binding]; other site 714962007619 catalytic residue [active] 714962007620 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 714962007621 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 714962007622 GAF domain; Region: GAF; cl17456 714962007623 Histidine kinase; Region: His_kinase; pfam06580 714962007624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962007625 ATP binding site [chemical binding]; other site 714962007626 Mg2+ binding site [ion binding]; other site 714962007627 G-X-G motif; other site 714962007628 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 714962007629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962007630 active site 714962007631 phosphorylation site [posttranslational modification] 714962007632 intermolecular recognition site; other site 714962007633 dimerization interface [polypeptide binding]; other site 714962007634 LytTr DNA-binding domain; Region: LytTR; pfam04397 714962007635 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714962007636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962007637 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 714962007638 dimerization domain swap beta strand [polypeptide binding]; other site 714962007639 regulatory protein interface [polypeptide binding]; other site 714962007640 active site 714962007641 regulatory phosphorylation site [posttranslational modification]; other site 714962007642 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 714962007643 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 714962007644 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 714962007645 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 714962007646 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 714962007647 active site 714962007648 phosphorylation site [posttranslational modification] 714962007649 exoaminopeptidase; Provisional; Region: PRK09961 714962007650 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 714962007651 oligomer interface [polypeptide binding]; other site 714962007652 active site 714962007653 metal binding site [ion binding]; metal-binding site 714962007654 aminopeptidase; Provisional; Region: PRK09795 714962007655 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 714962007656 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 714962007657 active site 714962007658 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 714962007659 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 714962007660 active site 714962007661 P-loop; other site 714962007662 phosphorylation site [posttranslational modification] 714962007663 glucokinase, proteobacterial type; Region: glk; TIGR00749 714962007664 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 714962007665 nucleotide binding site [chemical binding]; other site 714962007666 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 714962007667 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 714962007668 Cl- selectivity filter; other site 714962007669 Cl- binding residues [ion binding]; other site 714962007670 pore gating glutamate residue; other site 714962007671 dimer interface [polypeptide binding]; other site 714962007672 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 714962007673 manganese transport protein MntH; Reviewed; Region: PRK00701 714962007674 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 714962007675 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 714962007676 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 714962007677 Nucleoside recognition; Region: Gate; pfam07670 714962007678 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 714962007679 MASE1; Region: MASE1; pfam05231 714962007680 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 714962007681 diguanylate cyclase; Region: GGDEF; smart00267 714962007682 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714962007683 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 714962007684 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714962007685 salt bridge; other site 714962007686 non-specific DNA binding site [nucleotide binding]; other site 714962007687 sequence-specific DNA binding site [nucleotide binding]; other site 714962007688 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 714962007689 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 714962007690 active site 714962007691 HIGH motif; other site 714962007692 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 714962007693 active site 714962007694 KMSKS motif; other site 714962007695 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 714962007696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962007697 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 714962007698 putative dimerization interface [polypeptide binding]; other site 714962007699 putative substrate binding pocket [chemical binding]; other site 714962007700 XapX domain; Region: XapX; TIGR03510 714962007701 nucleoside transporter; Region: 2A0110; TIGR00889 714962007702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962007703 putative substrate translocation pore; other site 714962007704 purine nucleoside phosphorylase; Provisional; Region: PRK08202 714962007705 hypothetical protein; Provisional; Region: PRK11528 714962007706 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714962007707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962007708 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 714962007709 putative dimerization interface [polypeptide binding]; other site 714962007710 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 714962007711 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 714962007712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 714962007713 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 714962007714 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 714962007715 nucleotide binding pocket [chemical binding]; other site 714962007716 K-X-D-G motif; other site 714962007717 catalytic site [active] 714962007718 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 714962007719 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 714962007720 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 714962007721 Dimer interface [polypeptide binding]; other site 714962007722 BRCT sequence motif; other site 714962007723 cell division protein ZipA; Provisional; Region: PRK03427 714962007724 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 714962007725 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 714962007726 FtsZ protein binding site [polypeptide binding]; other site 714962007727 putative sulfate transport protein CysZ; Validated; Region: PRK04949 714962007728 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 714962007729 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 714962007730 dimer interface [polypeptide binding]; other site 714962007731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962007732 catalytic residue [active] 714962007733 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 714962007734 dimerization domain swap beta strand [polypeptide binding]; other site 714962007735 regulatory protein interface [polypeptide binding]; other site 714962007736 active site 714962007737 regulatory phosphorylation site [posttranslational modification]; other site 714962007738 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 714962007739 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 714962007740 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 714962007741 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 714962007742 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 714962007743 HPr interaction site; other site 714962007744 glycerol kinase (GK) interaction site [polypeptide binding]; other site 714962007745 active site 714962007746 phosphorylation site [posttranslational modification] 714962007747 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 714962007748 dimer interface [polypeptide binding]; other site 714962007749 pyridoxamine kinase; Validated; Region: PRK05756 714962007750 pyridoxal binding site [chemical binding]; other site 714962007751 ATP binding site [chemical binding]; other site 714962007752 hypothetical protein; Provisional; Region: PRK10318 714962007753 cysteine synthase B; Region: cysM; TIGR01138 714962007754 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 714962007755 dimer interface [polypeptide binding]; other site 714962007756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962007757 catalytic residue [active] 714962007758 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 714962007759 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 714962007760 Walker A/P-loop; other site 714962007761 ATP binding site [chemical binding]; other site 714962007762 Q-loop/lid; other site 714962007763 ABC transporter signature motif; other site 714962007764 Walker B; other site 714962007765 D-loop; other site 714962007766 H-loop/switch region; other site 714962007767 TOBE-like domain; Region: TOBE_3; pfam12857 714962007768 sulfate transport protein; Provisional; Region: cysT; CHL00187 714962007769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962007770 dimer interface [polypeptide binding]; other site 714962007771 conserved gate region; other site 714962007772 putative PBP binding loops; other site 714962007773 ABC-ATPase subunit interface; other site 714962007774 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 714962007775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962007776 dimer interface [polypeptide binding]; other site 714962007777 conserved gate region; other site 714962007778 putative PBP binding loops; other site 714962007779 ABC-ATPase subunit interface; other site 714962007780 thiosulfate transporter subunit; Provisional; Region: PRK10852 714962007781 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 714962007782 short chain dehydrogenase; Provisional; Region: PRK08226 714962007783 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 714962007784 NAD binding site [chemical binding]; other site 714962007785 homotetramer interface [polypeptide binding]; other site 714962007786 homodimer interface [polypeptide binding]; other site 714962007787 active site 714962007788 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 714962007789 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 714962007790 putative active site [active] 714962007791 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 714962007792 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714962007793 active site turn [active] 714962007794 phosphorylation site [posttranslational modification] 714962007795 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 714962007796 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 714962007797 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 714962007798 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 714962007799 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 714962007800 putative acetyltransferase; Provisional; Region: PRK03624 714962007801 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714962007802 Coenzyme A binding pocket [chemical binding]; other site 714962007803 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 714962007804 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 714962007805 active site 714962007806 metal binding site [ion binding]; metal-binding site 714962007807 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 714962007808 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 714962007809 transcriptional regulator EutR; Provisional; Region: PRK10130 714962007810 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962007811 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962007812 carboxysome structural protein EutK; Provisional; Region: PRK15466 714962007813 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 714962007814 Hexamer interface [polypeptide binding]; other site 714962007815 Hexagonal pore residue; other site 714962007816 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 714962007817 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 714962007818 putative hexamer interface [polypeptide binding]; other site 714962007819 putative hexagonal pore; other site 714962007820 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 714962007821 putative hexamer interface [polypeptide binding]; other site 714962007822 putative hexagonal pore; other site 714962007823 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 714962007824 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 714962007825 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 714962007826 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 714962007827 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 714962007828 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 714962007829 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 714962007830 active site 714962007831 metal binding site [ion binding]; metal-binding site 714962007832 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 714962007833 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 714962007834 nucleotide binding site [chemical binding]; other site 714962007835 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 714962007836 putative catalytic cysteine [active] 714962007837 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 714962007838 Hexamer/Pentamer interface [polypeptide binding]; other site 714962007839 central pore; other site 714962007840 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 714962007841 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 714962007842 Hexamer interface [polypeptide binding]; other site 714962007843 Putative hexagonal pore residue; other site 714962007844 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 714962007845 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 714962007846 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 714962007847 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 714962007848 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 714962007849 G1 box; other site 714962007850 GTP/Mg2+ binding site [chemical binding]; other site 714962007851 G2 box; other site 714962007852 Switch I region; other site 714962007853 G3 box; other site 714962007854 Switch II region; other site 714962007855 G4 box; other site 714962007856 G5 box; other site 714962007857 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 714962007858 putative hexamer interface [polypeptide binding]; other site 714962007859 putative hexagonal pore; other site 714962007860 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 714962007861 Malic enzyme, N-terminal domain; Region: malic; pfam00390 714962007862 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 714962007863 putative NAD(P) binding site [chemical binding]; other site 714962007864 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 714962007865 transaldolase-like protein; Provisional; Region: PTZ00411 714962007866 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 714962007867 active site 714962007868 dimer interface [polypeptide binding]; other site 714962007869 catalytic residue [active] 714962007870 transketolase; Reviewed; Region: PRK12753 714962007871 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 714962007872 TPP-binding site [chemical binding]; other site 714962007873 dimer interface [polypeptide binding]; other site 714962007874 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 714962007875 PYR/PP interface [polypeptide binding]; other site 714962007876 dimer interface [polypeptide binding]; other site 714962007877 TPP binding site [chemical binding]; other site 714962007878 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 714962007879 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 714962007880 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 714962007881 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 714962007882 dimer interface [polypeptide binding]; other site 714962007883 ADP-ribose binding site [chemical binding]; other site 714962007884 active site 714962007885 nudix motif; other site 714962007886 metal binding site [ion binding]; metal-binding site 714962007887 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 714962007888 4Fe-4S binding domain; Region: Fer4; pfam00037 714962007889 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 714962007890 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714962007891 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 714962007892 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 714962007893 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714962007894 dimerization interface [polypeptide binding]; other site 714962007895 Histidine kinase; Region: HisKA_3; pfam07730 714962007896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962007897 ATP binding site [chemical binding]; other site 714962007898 Mg2+ binding site [ion binding]; other site 714962007899 G-X-G motif; other site 714962007900 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 714962007901 Protein export membrane protein; Region: SecD_SecF; cl14618 714962007902 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 714962007903 ArsC family; Region: ArsC; pfam03960 714962007904 putative catalytic residues [active] 714962007905 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 714962007906 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 714962007907 metal binding site [ion binding]; metal-binding site 714962007908 dimer interface [polypeptide binding]; other site 714962007909 hypothetical protein; Provisional; Region: PRK13664 714962007910 putative hydrolase; Provisional; Region: PRK11460 714962007911 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 714962007912 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 714962007913 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 714962007914 Helicase; Region: Helicase_RecD; pfam05127 714962007915 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 714962007916 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 714962007917 Predicted metalloprotease [General function prediction only]; Region: COG2321 714962007918 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 714962007919 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 714962007920 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 714962007921 ATP binding site [chemical binding]; other site 714962007922 active site 714962007923 substrate binding site [chemical binding]; other site 714962007924 lipoprotein; Provisional; Region: PRK11679 714962007925 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 714962007926 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 714962007927 dihydrodipicolinate synthase; Region: dapA; TIGR00674 714962007928 dimer interface [polypeptide binding]; other site 714962007929 active site 714962007930 catalytic residue [active] 714962007931 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 714962007932 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 714962007933 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 714962007934 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 714962007935 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 714962007936 catalytic triad [active] 714962007937 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 714962007938 Domain of unknown function DUF20; Region: UPF0118; pfam01594 714962007939 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 714962007940 Peptidase family M48; Region: Peptidase_M48; cl12018 714962007941 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 714962007942 ArsC family; Region: ArsC; pfam03960 714962007943 catalytic residues [active] 714962007944 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 714962007945 DNA replication initiation factor; Provisional; Region: PRK08084 714962007946 uracil transporter; Provisional; Region: PRK10720 714962007947 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714962007948 active site 714962007949 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 714962007950 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 714962007951 dimerization interface [polypeptide binding]; other site 714962007952 putative ATP binding site [chemical binding]; other site 714962007953 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 714962007954 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 714962007955 active site 714962007956 substrate binding site [chemical binding]; other site 714962007957 cosubstrate binding site; other site 714962007958 catalytic site [active] 714962007959 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 714962007960 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 714962007961 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 714962007962 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 714962007963 domain interface [polypeptide binding]; other site 714962007964 active site 714962007965 catalytic site [active] 714962007966 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 714962007967 putative active site [active] 714962007968 catalytic site [active] 714962007969 exopolyphosphatase; Provisional; Region: PRK10854 714962007970 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 714962007971 MASE1; Region: MASE1; pfam05231 714962007972 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 714962007973 diguanylate cyclase; Region: GGDEF; smart00267 714962007974 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714962007975 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 714962007976 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 714962007977 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 714962007978 Predicted chitinase [General function prediction only]; Region: COG3179 714962007979 catalytic residue [active] 714962007980 N terminal extension of bacteriophage endosialidase; Region: End_N_terminal; pfam12218 714962007981 Catalytic beta propeller domain of bacteriophage endosialidase; Region: End_beta_propel; cl12167 714962007982 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 714962007983 Asp-box motif; other site 714962007984 catalytic site [active] 714962007985 Catalytic domain of bacteriophage endosialidase; Region: End_tail_spike; pfam12219 714962007986 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 714962007987 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; cl08066 714962007988 phosphodiesterase; Provisional; Region: PRK12704 714962007989 virion protein; Provisional; Region: V; PHA02564 714962007990 Domain of unknown function (DUF3449); Region: DUF3449; pfam11931 714962007991 hypothetical protein; Region: PHA01733 714962007992 hypothetical protein; Region: PHA00661 714962007993 hypothetical protein; Region: PHA00662 714962007994 hypothetical protein; Region: PHA00669 714962007995 hypothetical protein; Region: PHA00664 714962007996 major capsid protein; Region: PHA00665 714962007997 putative protease; Region: PHA00666 714962007998 hypothetical protein; Region: PHA00670 714962007999 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 714962008000 Terminase small subunit; Region: Terminase_2; pfam03592 714962008001 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 714962008002 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 714962008003 Protein of unknown function (DUF551); Region: DUF551; pfam04448 714962008004 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 714962008005 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 714962008006 Replication protein P; Region: Phage_lambda_P; pfam06992 714962008007 Pyocin large subunit [General function prediction only]; Region: COG5529 714962008008 Helix-turn-helix domain; Region: HTH_36; pfam13730 714962008009 primosomal protein DnaI; Provisional; Region: PRK02854 714962008010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714962008011 sequence-specific DNA binding site [nucleotide binding]; other site 714962008012 salt bridge; other site 714962008013 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 714962008014 RecT family; Region: RecT; pfam03837 714962008015 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 714962008016 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 714962008017 integrase; Provisional; Region: PRK09692 714962008018 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 714962008019 active site 714962008020 Int/Topo IB signature motif; other site 714962008021 GMP synthase; Reviewed; Region: guaA; PRK00074 714962008022 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 714962008023 AMP/PPi binding site [chemical binding]; other site 714962008024 candidate oxyanion hole; other site 714962008025 catalytic triad [active] 714962008026 potential glutamine specificity residues [chemical binding]; other site 714962008027 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 714962008028 ATP Binding subdomain [chemical binding]; other site 714962008029 Ligand Binding sites [chemical binding]; other site 714962008030 Dimerization subdomain; other site 714962008031 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 714962008032 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 714962008033 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 714962008034 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 714962008035 active site 714962008036 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 714962008037 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 714962008038 generic binding surface II; other site 714962008039 generic binding surface I; other site 714962008040 RatA-like protein; Provisional; Region: PRK15316 714962008041 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 714962008042 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 714962008043 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 714962008044 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 714962008045 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 714962008046 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 714962008047 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 714962008048 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 714962008049 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 714962008050 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 714962008051 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 714962008052 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 714962008053 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 714962008054 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 714962008055 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 714962008056 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 714962008057 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 714962008058 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 714962008059 intimin-like protein SinH; Provisional; Region: PRK15318 714962008060 intimin-like protein SinH; Provisional; Region: PRK15318 714962008061 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 714962008062 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 714962008063 GTP-binding protein Der; Reviewed; Region: PRK00093 714962008064 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 714962008065 G1 box; other site 714962008066 GTP/Mg2+ binding site [chemical binding]; other site 714962008067 Switch I region; other site 714962008068 G2 box; other site 714962008069 Switch II region; other site 714962008070 G3 box; other site 714962008071 G4 box; other site 714962008072 G5 box; other site 714962008073 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 714962008074 G1 box; other site 714962008075 GTP/Mg2+ binding site [chemical binding]; other site 714962008076 Switch I region; other site 714962008077 G2 box; other site 714962008078 G3 box; other site 714962008079 Switch II region; other site 714962008080 G4 box; other site 714962008081 G5 box; other site 714962008082 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 714962008083 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 714962008084 Trp docking motif [polypeptide binding]; other site 714962008085 active site 714962008086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 714962008087 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 714962008088 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 714962008089 dimer interface [polypeptide binding]; other site 714962008090 motif 1; other site 714962008091 active site 714962008092 motif 2; other site 714962008093 motif 3; other site 714962008094 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 714962008095 anticodon binding site; other site 714962008096 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 714962008097 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 714962008098 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 714962008099 cytoskeletal protein RodZ; Provisional; Region: PRK10856 714962008100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714962008101 non-specific DNA binding site [nucleotide binding]; other site 714962008102 salt bridge; other site 714962008103 sequence-specific DNA binding site [nucleotide binding]; other site 714962008104 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 714962008105 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 714962008106 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714962008107 FeS/SAM binding site; other site 714962008108 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 714962008109 active site 714962008110 multimer interface [polypeptide binding]; other site 714962008111 penicillin-binding protein 1C; Provisional; Region: PRK11240 714962008112 Transglycosylase; Region: Transgly; pfam00912 714962008113 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 714962008114 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 714962008115 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 714962008116 MG2 domain; Region: A2M_N; pfam01835 714962008117 Alpha-2-macroglobulin family; Region: A2M; pfam00207 714962008118 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 714962008119 surface patch; other site 714962008120 thioester region; other site 714962008121 specificity defining residues; other site 714962008122 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 714962008123 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 714962008124 active site residue [active] 714962008125 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 714962008126 active site residue [active] 714962008127 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 714962008128 aminopeptidase B; Provisional; Region: PRK05015 714962008129 Peptidase; Region: DUF3663; pfam12404 714962008130 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 714962008131 interface (dimer of trimers) [polypeptide binding]; other site 714962008132 Substrate-binding/catalytic site; other site 714962008133 Zn-binding sites [ion binding]; other site 714962008134 hypothetical protein; Provisional; Region: PRK10721 714962008135 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 714962008136 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 714962008137 catalytic loop [active] 714962008138 iron binding site [ion binding]; other site 714962008139 chaperone protein HscA; Provisional; Region: hscA; PRK05183 714962008140 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 714962008141 nucleotide binding site [chemical binding]; other site 714962008142 putative NEF/HSP70 interaction site [polypeptide binding]; other site 714962008143 SBD interface [polypeptide binding]; other site 714962008144 co-chaperone HscB; Provisional; Region: hscB; PRK05014 714962008145 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 714962008146 HSP70 interaction site [polypeptide binding]; other site 714962008147 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 714962008148 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 714962008149 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 714962008150 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 714962008151 trimerization site [polypeptide binding]; other site 714962008152 active site 714962008153 cysteine desulfurase; Provisional; Region: PRK14012 714962008154 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 714962008155 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714962008156 catalytic residue [active] 714962008157 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 714962008158 Rrf2 family protein; Region: rrf2_super; TIGR00738 714962008159 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 714962008160 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 714962008161 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 714962008162 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 714962008163 active site 714962008164 dimerization interface [polypeptide binding]; other site 714962008165 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 714962008166 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 714962008167 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 714962008168 PRD domain; Region: PRD; pfam00874 714962008169 PRD domain; Region: PRD; pfam00874 714962008170 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 714962008171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962008172 putative substrate translocation pore; other site 714962008173 Predicted membrane protein [Function unknown]; Region: COG2259 714962008174 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 714962008175 active site 714962008176 catalytic residues [active] 714962008177 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 714962008178 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 714962008179 putative NAD(P) binding site [chemical binding]; other site 714962008180 catalytic Zn binding site [ion binding]; other site 714962008181 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 714962008182 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 714962008183 TM-ABC transporter signature motif; other site 714962008184 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 714962008185 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 714962008186 Walker A/P-loop; other site 714962008187 ATP binding site [chemical binding]; other site 714962008188 Q-loop/lid; other site 714962008189 ABC transporter signature motif; other site 714962008190 Walker B; other site 714962008191 D-loop; other site 714962008192 H-loop/switch region; other site 714962008193 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 714962008194 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 714962008195 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 714962008196 ligand binding site [chemical binding]; other site 714962008197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714962008198 TPR motif; other site 714962008199 Tetratricopeptide repeat; Region: TPR_16; pfam13432 714962008200 binding surface 714962008201 TPR repeat; Region: TPR_11; pfam13414 714962008202 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714962008203 TPR motif; other site 714962008204 binding surface 714962008205 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 714962008206 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 714962008207 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 714962008208 nucleotide binding site [chemical binding]; other site 714962008209 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 714962008210 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 714962008211 dimer interface [polypeptide binding]; other site 714962008212 active site 714962008213 glycine-pyridoxal phosphate binding site [chemical binding]; other site 714962008214 folate binding site [chemical binding]; other site 714962008215 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 714962008216 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 714962008217 heme-binding site [chemical binding]; other site 714962008218 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 714962008219 FAD binding pocket [chemical binding]; other site 714962008220 FAD binding motif [chemical binding]; other site 714962008221 phosphate binding motif [ion binding]; other site 714962008222 beta-alpha-beta structure motif; other site 714962008223 NAD binding pocket [chemical binding]; other site 714962008224 Heme binding pocket [chemical binding]; other site 714962008225 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 714962008226 Nitrogen regulatory protein P-II; Region: P-II; smart00938 714962008227 response regulator GlrR; Provisional; Region: PRK15115 714962008228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962008229 active site 714962008230 phosphorylation site [posttranslational modification] 714962008231 intermolecular recognition site; other site 714962008232 dimerization interface [polypeptide binding]; other site 714962008233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962008234 Walker A motif; other site 714962008235 ATP binding site [chemical binding]; other site 714962008236 Walker B motif; other site 714962008237 arginine finger; other site 714962008238 hypothetical protein; Provisional; Region: PRK10722 714962008239 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714962008240 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962008241 dimer interface [polypeptide binding]; other site 714962008242 phosphorylation site [posttranslational modification] 714962008243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962008244 ATP binding site [chemical binding]; other site 714962008245 Mg2+ binding site [ion binding]; other site 714962008246 G-X-G motif; other site 714962008247 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 714962008248 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 714962008249 dimerization interface [polypeptide binding]; other site 714962008250 ATP binding site [chemical binding]; other site 714962008251 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 714962008252 dimerization interface [polypeptide binding]; other site 714962008253 ATP binding site [chemical binding]; other site 714962008254 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 714962008255 putative active site [active] 714962008256 catalytic triad [active] 714962008257 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 714962008258 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714962008259 substrate binding pocket [chemical binding]; other site 714962008260 membrane-bound complex binding site; other site 714962008261 hinge residues; other site 714962008262 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 714962008263 N-acetyl-D-glucosamine binding site [chemical binding]; other site 714962008264 catalytic residue [active] 714962008265 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 714962008266 nucleoside/Zn binding site; other site 714962008267 dimer interface [polypeptide binding]; other site 714962008268 catalytic motif [active] 714962008269 hypothetical protein; Provisional; Region: PRK11590 714962008270 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 714962008271 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 714962008272 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 714962008273 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 714962008274 putative active site [active] 714962008275 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 714962008276 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 714962008277 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 714962008278 active site 714962008279 hydrophilic channel; other site 714962008280 dimerization interface [polypeptide binding]; other site 714962008281 catalytic residues [active] 714962008282 active site lid [active] 714962008283 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 714962008284 Recombination protein O N terminal; Region: RecO_N; pfam11967 714962008285 Recombination protein O C terminal; Region: RecO_C; pfam02565 714962008286 GTPase Era; Reviewed; Region: era; PRK00089 714962008287 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 714962008288 G1 box; other site 714962008289 GTP/Mg2+ binding site [chemical binding]; other site 714962008290 Switch I region; other site 714962008291 G2 box; other site 714962008292 Switch II region; other site 714962008293 G3 box; other site 714962008294 G4 box; other site 714962008295 G5 box; other site 714962008296 KH domain; Region: KH_2; pfam07650 714962008297 ribonuclease III; Reviewed; Region: rnc; PRK00102 714962008298 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 714962008299 dimerization interface [polypeptide binding]; other site 714962008300 active site 714962008301 metal binding site [ion binding]; metal-binding site 714962008302 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 714962008303 dsRNA binding site [nucleotide binding]; other site 714962008304 signal peptidase I; Provisional; Region: PRK10861 714962008305 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714962008306 Catalytic site [active] 714962008307 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714962008308 GTP-binding protein LepA; Provisional; Region: PRK05433 714962008309 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 714962008310 G1 box; other site 714962008311 putative GEF interaction site [polypeptide binding]; other site 714962008312 GTP/Mg2+ binding site [chemical binding]; other site 714962008313 Switch I region; other site 714962008314 G2 box; other site 714962008315 G3 box; other site 714962008316 Switch II region; other site 714962008317 G4 box; other site 714962008318 G5 box; other site 714962008319 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 714962008320 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 714962008321 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 714962008322 SoxR reducing system protein RseC; Provisional; Region: PRK10862 714962008323 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 714962008324 anti-sigma E factor; Provisional; Region: rseB; PRK09455 714962008325 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 714962008326 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 714962008327 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 714962008328 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 714962008329 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714962008330 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714962008331 DNA binding residues [nucleotide binding] 714962008332 L-aspartate oxidase; Provisional; Region: PRK09077 714962008333 L-aspartate oxidase; Provisional; Region: PRK06175 714962008334 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 714962008335 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 714962008336 Methyltransferase domain; Region: Methyltransf_26; pfam13659 714962008337 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 714962008338 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 714962008339 ATP binding site [chemical binding]; other site 714962008340 Mg++ binding site [ion binding]; other site 714962008341 motif III; other site 714962008342 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714962008343 nucleotide binding region [chemical binding]; other site 714962008344 ATP-binding site [chemical binding]; other site 714962008345 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714962008346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962008347 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714962008348 dimerization interface [polypeptide binding]; other site 714962008349 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 714962008350 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 714962008351 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 714962008352 ligand binding site [chemical binding]; other site 714962008353 active site 714962008354 UGI interface [polypeptide binding]; other site 714962008355 catalytic site [active] 714962008356 putative methyltransferase; Provisional; Region: PRK10864 714962008357 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 714962008358 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 714962008359 thioredoxin 2; Provisional; Region: PRK10996 714962008360 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 714962008361 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714962008362 catalytic residues [active] 714962008363 Uncharacterized conserved protein [Function unknown]; Region: COG3148 714962008364 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 714962008365 CoA binding domain; Region: CoA_binding_2; pfam13380 714962008366 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 714962008367 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 714962008368 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 714962008369 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 714962008370 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 714962008371 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 714962008372 domain interface [polypeptide binding]; other site 714962008373 putative active site [active] 714962008374 catalytic site [active] 714962008375 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 714962008376 domain interface [polypeptide binding]; other site 714962008377 putative active site [active] 714962008378 catalytic site [active] 714962008379 lipoprotein; Provisional; Region: PRK10759 714962008380 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 714962008381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962008382 putative substrate translocation pore; other site 714962008383 protein disaggregation chaperone; Provisional; Region: PRK10865 714962008384 Clp amino terminal domain; Region: Clp_N; pfam02861 714962008385 Clp amino terminal domain; Region: Clp_N; pfam02861 714962008386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962008387 Walker A motif; other site 714962008388 ATP binding site [chemical binding]; other site 714962008389 Walker B motif; other site 714962008390 arginine finger; other site 714962008391 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962008392 Walker A motif; other site 714962008393 ATP binding site [chemical binding]; other site 714962008394 Walker B motif; other site 714962008395 arginine finger; other site 714962008396 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 714962008397 hypothetical protein; Provisional; Region: PRK10723 714962008398 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 714962008399 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 714962008400 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714962008401 RNA binding surface [nucleotide binding]; other site 714962008402 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 714962008403 active site 714962008404 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 714962008405 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 714962008406 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 714962008407 30S subunit binding site; other site 714962008408 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 714962008409 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 714962008410 Prephenate dehydratase; Region: PDT; pfam00800 714962008411 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 714962008412 putative L-Phe binding site [chemical binding]; other site 714962008413 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 714962008414 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 714962008415 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 714962008416 prephenate dehydrogenase; Validated; Region: PRK08507 714962008417 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 714962008418 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 714962008419 lipoprotein; Provisional; Region: PRK11443 714962008420 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 714962008421 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 714962008422 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 714962008423 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714962008424 metal binding site [ion binding]; metal-binding site 714962008425 active site 714962008426 I-site; other site 714962008427 putative outer membrane lipoprotein; Provisional; Region: PRK09967 714962008428 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 714962008429 ligand binding site [chemical binding]; other site 714962008430 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 714962008431 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 714962008432 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 714962008433 RimM N-terminal domain; Region: RimM; pfam01782 714962008434 PRC-barrel domain; Region: PRC; pfam05239 714962008435 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 714962008436 signal recognition particle protein; Provisional; Region: PRK10867 714962008437 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 714962008438 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 714962008439 P loop; other site 714962008440 GTP binding site [chemical binding]; other site 714962008441 Signal peptide binding domain; Region: SRP_SPB; pfam02978 714962008442 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 714962008443 hypothetical protein; Provisional; Region: PRK11573 714962008444 Domain of unknown function DUF21; Region: DUF21; pfam01595 714962008445 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 714962008446 Transporter associated domain; Region: CorC_HlyC; smart01091 714962008447 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 714962008448 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 714962008449 dimer interface [polypeptide binding]; other site 714962008450 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 714962008451 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 714962008452 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 714962008453 recombination and repair protein; Provisional; Region: PRK10869 714962008454 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 714962008455 Walker A/P-loop; other site 714962008456 ATP binding site [chemical binding]; other site 714962008457 Q-loop/lid; other site 714962008458 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 714962008459 Q-loop/lid; other site 714962008460 ABC transporter signature motif; other site 714962008461 Walker B; other site 714962008462 D-loop; other site 714962008463 H-loop/switch region; other site 714962008464 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 714962008465 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 714962008466 hypothetical protein; Validated; Region: PRK01777 714962008467 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 714962008468 putative coenzyme Q binding site [chemical binding]; other site 714962008469 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 714962008470 SmpB-tmRNA interface; other site 714962008471 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 714962008472 GIY-YIG motif/motif A; other site 714962008473 putative active site [active] 714962008474 putative metal binding site [ion binding]; other site 714962008475 DinI-like family; Region: DinI; cl11630 714962008476 Uncharacterized conserved protein [Function unknown]; Region: COG1479 714962008477 Protein of unknown function DUF262; Region: DUF262; pfam03235 714962008478 Protein of unknown function DUF262; Region: DUF262; pfam03235 714962008479 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 714962008480 Phage Tail Collar Domain; Region: Collar; pfam07484 714962008481 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 714962008482 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 714962008483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 714962008484 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 714962008485 Phage protein GP46; Region: GP46; pfam07409 714962008486 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 714962008487 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890 714962008488 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 714962008489 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 714962008490 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 714962008491 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 714962008492 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 714962008493 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 714962008494 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 714962008495 Phage tail tube protein; Region: Tail_tube; pfam10618 714962008496 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 714962008497 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 714962008498 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 714962008499 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 714962008500 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 714962008501 oligomerization interface [polypeptide binding]; other site 714962008502 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 714962008503 Phage capsid family; Region: Phage_capsid; pfam05065 714962008504 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 714962008505 Phage-related protein [Function unknown]; Region: COG4695 714962008506 Phage portal protein; Region: Phage_portal; pfam04860 714962008507 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 714962008508 Phage terminase, small subunit; Region: Terminase_4; pfam05119 714962008509 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 714962008510 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 714962008511 active site 714962008512 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 714962008513 N-acetyl-D-glucosamine binding site [chemical binding]; other site 714962008514 catalytic residue [active] 714962008515 Antitermination protein; Region: Antiterm; pfam03589 714962008516 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 714962008517 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 714962008518 Zn binding sites [ion binding]; other site 714962008519 Antitermination protein; Region: Antiterm; pfam03589 714962008520 Protein of unknown function (DUF968); Region: DUF968; pfam06147 714962008521 KilA-N domain; Region: KilA-N; pfam04383 714962008522 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 714962008523 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 714962008524 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 714962008525 PerC transcriptional activator; Region: PerC; pfam06069 714962008526 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962008527 DNA-binding site [nucleotide binding]; DNA binding site 714962008528 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 714962008529 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 714962008530 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 714962008531 Catalytic site [active] 714962008532 Uncharacterized conserved protein [Function unknown]; Region: COG5532 714962008533 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 714962008534 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 714962008535 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 714962008536 Int/Topo IB signature motif; other site 714962008537 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 714962008538 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 714962008539 substrate binding pocket [chemical binding]; other site 714962008540 active site 714962008541 iron coordination sites [ion binding]; other site 714962008542 Predicted dehydrogenase [General function prediction only]; Region: COG0579 714962008543 hydroxyglutarate oxidase; Provisional; Region: PRK11728 714962008544 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 714962008545 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 714962008546 tetramerization interface [polypeptide binding]; other site 714962008547 NAD(P) binding site [chemical binding]; other site 714962008548 catalytic residues [active] 714962008549 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 714962008550 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714962008551 inhibitor-cofactor binding pocket; inhibition site 714962008552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962008553 catalytic residue [active] 714962008554 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 714962008555 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 714962008556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962008557 DNA-binding site [nucleotide binding]; DNA binding site 714962008558 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 714962008559 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 714962008560 bacterial OsmY and nodulation domain; Region: BON; smart00749 714962008561 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 714962008562 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 714962008563 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714962008564 dimerization interface [polypeptide binding]; other site 714962008565 putative DNA binding site [nucleotide binding]; other site 714962008566 Transcriptional regulators [Transcription]; Region: MarR; COG1846 714962008567 putative Zn2+ binding site [ion binding]; other site 714962008568 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 714962008569 active site residue [active] 714962008570 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 714962008571 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 714962008572 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 714962008573 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 714962008574 hypothetical protein; Provisional; Region: PRK10556 714962008575 hypothetical protein; Provisional; Region: PRK10132 714962008576 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 714962008577 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962008578 DNA-binding site [nucleotide binding]; DNA binding site 714962008579 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714962008580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962008581 homodimer interface [polypeptide binding]; other site 714962008582 catalytic residue [active] 714962008583 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 714962008584 Uncharacterized conserved protein [Function unknown]; Region: COG2128 714962008585 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 714962008586 catalytic residues [active] 714962008587 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 714962008588 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 714962008589 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 714962008590 Class I ribonucleotide reductase; Region: RNR_I; cd01679 714962008591 active site 714962008592 dimer interface [polypeptide binding]; other site 714962008593 catalytic residues [active] 714962008594 effector binding site; other site 714962008595 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 714962008596 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 714962008597 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 714962008598 dimer interface [polypeptide binding]; other site 714962008599 putative radical transfer pathway; other site 714962008600 diiron center [ion binding]; other site 714962008601 tyrosyl radical; other site 714962008602 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 714962008603 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 714962008604 Walker A/P-loop; other site 714962008605 ATP binding site [chemical binding]; other site 714962008606 Q-loop/lid; other site 714962008607 ABC transporter signature motif; other site 714962008608 Walker B; other site 714962008609 D-loop; other site 714962008610 H-loop/switch region; other site 714962008611 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 714962008612 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 714962008613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962008614 dimer interface [polypeptide binding]; other site 714962008615 conserved gate region; other site 714962008616 putative PBP binding loops; other site 714962008617 ABC-ATPase subunit interface; other site 714962008618 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 714962008619 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 714962008620 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 714962008621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962008622 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 714962008623 putative L-valine exporter; Provisional; Region: PRK10408 714962008624 transcriptional repressor MprA; Provisional; Region: PRK10870 714962008625 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 714962008626 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 714962008627 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 714962008628 HlyD family secretion protein; Region: HlyD_3; pfam13437 714962008629 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 714962008630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962008631 putative substrate translocation pore; other site 714962008632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962008633 RNA ligase; Region: RNA_ligase; pfam09414 714962008634 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714962008635 Zn2+ binding site [ion binding]; other site 714962008636 Mg2+ binding site [ion binding]; other site 714962008637 AAA domain; Region: AAA_33; pfam13671 714962008638 S-ribosylhomocysteinase; Provisional; Region: PRK02260 714962008639 glutamate--cysteine ligase; Provisional; Region: PRK02107 714962008640 Predicted membrane protein [Function unknown]; Region: COG1238 714962008641 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 714962008642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962008643 motif II; other site 714962008644 carbon storage regulator; Provisional; Region: PRK01712 714962008645 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 714962008646 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 714962008647 motif 1; other site 714962008648 active site 714962008649 motif 2; other site 714962008650 motif 3; other site 714962008651 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 714962008652 DHHA1 domain; Region: DHHA1; pfam02272 714962008653 recombination regulator RecX; Reviewed; Region: recX; PRK00117 714962008654 recombinase A; Provisional; Region: recA; PRK09354 714962008655 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 714962008656 hexamer interface [polypeptide binding]; other site 714962008657 Walker A motif; other site 714962008658 ATP binding site [chemical binding]; other site 714962008659 Walker B motif; other site 714962008660 hypothetical protein; Validated; Region: PRK03661 714962008661 Transglycosylase SLT domain; Region: SLT_2; pfam13406 714962008662 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 714962008663 N-acetyl-D-glucosamine binding site [chemical binding]; other site 714962008664 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 714962008665 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 714962008666 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 714962008667 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 714962008668 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 714962008669 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 714962008670 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 714962008671 putative NAD(P) binding site [chemical binding]; other site 714962008672 active site 714962008673 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 714962008674 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 714962008675 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 714962008676 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 714962008677 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 714962008678 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 714962008679 putative active site [active] 714962008680 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 714962008681 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 714962008682 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 714962008683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962008684 Walker A motif; other site 714962008685 ATP binding site [chemical binding]; other site 714962008686 Walker B motif; other site 714962008687 arginine finger; other site 714962008688 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 714962008689 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714962008690 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 714962008691 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 714962008692 iron binding site [ion binding]; other site 714962008693 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 714962008694 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714962008695 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714962008696 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 714962008697 Acylphosphatase; Region: Acylphosphatase; pfam00708 714962008698 HypF finger; Region: zf-HYPF; pfam07503 714962008699 HypF finger; Region: zf-HYPF; pfam07503 714962008700 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 714962008701 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 714962008702 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 714962008703 Transcriptional regulators [Transcription]; Region: PurR; COG1609 714962008704 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714962008705 DNA binding site [nucleotide binding] 714962008706 domain linker motif; other site 714962008707 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 714962008708 dimerization interface (closed form) [polypeptide binding]; other site 714962008709 ligand binding site [chemical binding]; other site 714962008710 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 714962008711 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714962008712 active site turn [active] 714962008713 phosphorylation site [posttranslational modification] 714962008714 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 714962008715 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 714962008716 beta-galactosidase; Region: BGL; TIGR03356 714962008717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714962008718 non-specific DNA binding site [nucleotide binding]; other site 714962008719 salt bridge; other site 714962008720 sequence-specific DNA binding site [nucleotide binding]; other site 714962008721 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 714962008722 nickel binding site [ion binding]; other site 714962008723 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 714962008724 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 714962008725 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 714962008726 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 714962008727 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 714962008728 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 714962008729 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 714962008730 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 714962008731 NADH dehydrogenase; Region: NADHdh; cl00469 714962008732 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 714962008733 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 714962008734 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 714962008735 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 714962008736 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 714962008737 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 714962008738 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 714962008739 hydrogenase assembly chaperone; Provisional; Region: PRK10409 714962008740 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 714962008741 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 714962008742 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 714962008743 dimerization interface [polypeptide binding]; other site 714962008744 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 714962008745 ATP binding site [chemical binding]; other site 714962008746 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 714962008747 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 714962008748 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 714962008749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962008750 Walker A motif; other site 714962008751 ATP binding site [chemical binding]; other site 714962008752 Walker B motif; other site 714962008753 arginine finger; other site 714962008754 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 714962008755 molybdenum-pterin binding domain; Region: Mop; TIGR00638 714962008756 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 714962008757 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 714962008758 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 714962008759 MutS domain I; Region: MutS_I; pfam01624 714962008760 MutS domain II; Region: MutS_II; pfam05188 714962008761 MutS domain III; Region: MutS_III; pfam05192 714962008762 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 714962008763 Walker A/P-loop; other site 714962008764 ATP binding site [chemical binding]; other site 714962008765 Q-loop/lid; other site 714962008766 ABC transporter signature motif; other site 714962008767 Walker B; other site 714962008768 D-loop; other site 714962008769 H-loop/switch region; other site 714962008770 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 714962008771 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714962008772 active site 714962008773 metal binding site [ion binding]; metal-binding site 714962008774 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 714962008775 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 714962008776 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 714962008777 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 714962008778 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 714962008779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 714962008780 putative aldolase; Validated; Region: PRK08130 714962008781 active site 714962008782 intersubunit interface [polypeptide binding]; other site 714962008783 Zn2+ binding site [ion binding]; other site 714962008784 hypothetical protein; Provisional; Region: PRK09989 714962008785 putative transporter; Provisional; Region: PRK09821 714962008786 GntP family permease; Region: GntP_permease; pfam02447 714962008787 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714962008788 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 714962008789 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 714962008790 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 714962008791 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 714962008792 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 714962008793 Peptidase family M23; Region: Peptidase_M23; pfam01551 714962008794 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 714962008795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962008796 S-adenosylmethionine binding site [chemical binding]; other site 714962008797 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 714962008798 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 714962008799 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 714962008800 Permutation of conserved domain; other site 714962008801 active site 714962008802 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 714962008803 homotrimer interaction site [polypeptide binding]; other site 714962008804 zinc binding site [ion binding]; other site 714962008805 CDP-binding sites; other site 714962008806 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 714962008807 substrate binding site; other site 714962008808 dimer interface; other site 714962008809 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 714962008810 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 714962008811 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 714962008812 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 714962008813 ligand-binding site [chemical binding]; other site 714962008814 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 714962008815 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 714962008816 CysD dimerization site [polypeptide binding]; other site 714962008817 G1 box; other site 714962008818 putative GEF interaction site [polypeptide binding]; other site 714962008819 GTP/Mg2+ binding site [chemical binding]; other site 714962008820 Switch I region; other site 714962008821 G2 box; other site 714962008822 G3 box; other site 714962008823 Switch II region; other site 714962008824 G4 box; other site 714962008825 G5 box; other site 714962008826 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 714962008827 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 714962008828 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 714962008829 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 714962008830 Active Sites [active] 714962008831 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 714962008832 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 714962008833 metal binding site [ion binding]; metal-binding site 714962008834 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 714962008835 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 714962008836 Active Sites [active] 714962008837 sulfite reductase subunit beta; Provisional; Region: PRK13504 714962008838 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 714962008839 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 714962008840 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 714962008841 Flavodoxin; Region: Flavodoxin_1; pfam00258 714962008842 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 714962008843 FAD binding pocket [chemical binding]; other site 714962008844 FAD binding motif [chemical binding]; other site 714962008845 catalytic residues [active] 714962008846 NAD binding pocket [chemical binding]; other site 714962008847 phosphate binding motif [ion binding]; other site 714962008848 beta-alpha-beta structure motif; other site 714962008849 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 714962008850 active site 714962008851 putative oxidoreductase FixC; Provisional; Region: PRK10157 714962008852 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 714962008853 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 714962008854 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 714962008855 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 714962008856 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 714962008857 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 714962008858 Ligand binding site [chemical binding]; other site 714962008859 Electron transfer flavoprotein domain; Region: ETF; pfam01012 714962008860 benzoate transport; Region: 2A0115; TIGR00895 714962008861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962008862 putative substrate translocation pore; other site 714962008863 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 714962008864 FAD binding domain; Region: FAD_binding_4; pfam01565 714962008865 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 714962008866 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 714962008867 NADP binding site [chemical binding]; other site 714962008868 homodimer interface [polypeptide binding]; other site 714962008869 active site 714962008870 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714962008871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962008872 putative substrate translocation pore; other site 714962008873 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 714962008874 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 714962008875 nucleotide binding site [chemical binding]; other site 714962008876 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 714962008877 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 714962008878 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 714962008879 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 714962008880 Repair protein; Region: Repair_PSII; pfam04536 714962008881 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 714962008882 Repair protein; Region: Repair_PSII; pfam04536 714962008883 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 714962008884 Repair protein; Region: Repair_PSII; pfam04536 714962008885 enolase; Provisional; Region: eno; PRK00077 714962008886 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 714962008887 dimer interface [polypeptide binding]; other site 714962008888 metal binding site [ion binding]; metal-binding site 714962008889 substrate binding pocket [chemical binding]; other site 714962008890 CTP synthetase; Validated; Region: pyrG; PRK05380 714962008891 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 714962008892 Catalytic site [active] 714962008893 active site 714962008894 UTP binding site [chemical binding]; other site 714962008895 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 714962008896 active site 714962008897 putative oxyanion hole; other site 714962008898 catalytic triad [active] 714962008899 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 714962008900 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 714962008901 homodimer interface [polypeptide binding]; other site 714962008902 metal binding site [ion binding]; metal-binding site 714962008903 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 714962008904 homodimer interface [polypeptide binding]; other site 714962008905 active site 714962008906 putative chemical substrate binding site [chemical binding]; other site 714962008907 metal binding site [ion binding]; metal-binding site 714962008908 toxin MazF; Provisional; Region: PRK09907 714962008909 antitoxin MazE; Provisional; Region: PRK09798 714962008910 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 714962008911 HD domain; Region: HD_4; pfam13328 714962008912 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 714962008913 synthetase active site [active] 714962008914 NTP binding site [chemical binding]; other site 714962008915 metal binding site [ion binding]; metal-binding site 714962008916 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 714962008917 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 714962008918 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 714962008919 TRAM domain; Region: TRAM; pfam01938 714962008920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962008921 S-adenosylmethionine binding site [chemical binding]; other site 714962008922 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 714962008923 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 714962008924 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714962008925 dimerization interface [polypeptide binding]; other site 714962008926 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962008927 dimer interface [polypeptide binding]; other site 714962008928 phosphorylation site [posttranslational modification] 714962008929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962008930 ATP binding site [chemical binding]; other site 714962008931 Mg2+ binding site [ion binding]; other site 714962008932 G-X-G motif; other site 714962008933 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 714962008934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962008935 active site 714962008936 phosphorylation site [posttranslational modification] 714962008937 intermolecular recognition site; other site 714962008938 dimerization interface [polypeptide binding]; other site 714962008939 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 714962008940 putative binding surface; other site 714962008941 active site 714962008942 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 714962008943 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 714962008944 active site 714962008945 tetramer interface [polypeptide binding]; other site 714962008946 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 714962008947 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 714962008948 active site 714962008949 tetramer interface [polypeptide binding]; other site 714962008950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962008951 D-galactonate transporter; Region: 2A0114; TIGR00893 714962008952 putative substrate translocation pore; other site 714962008953 flavodoxin; Provisional; Region: PRK08105 714962008954 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 714962008955 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 714962008956 probable active site [active] 714962008957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 714962008958 SecY interacting protein Syd; Provisional; Region: PRK04968 714962008959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 714962008960 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 714962008961 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 714962008962 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 714962008963 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 714962008964 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 714962008965 serine transporter; Region: stp; TIGR00814 714962008966 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 714962008967 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 714962008968 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 714962008969 flap endonuclease-like protein; Provisional; Region: PRK09482 714962008970 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 714962008971 active site 714962008972 metal binding site 1 [ion binding]; metal-binding site 714962008973 putative 5' ssDNA interaction site; other site 714962008974 metal binding site 3; metal-binding site 714962008975 metal binding site 2 [ion binding]; metal-binding site 714962008976 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 714962008977 putative DNA binding site [nucleotide binding]; other site 714962008978 putative metal binding site [ion binding]; other site 714962008979 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 714962008980 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 714962008981 dimer interface [polypeptide binding]; other site 714962008982 active site 714962008983 metal binding site [ion binding]; metal-binding site 714962008984 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 714962008985 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 714962008986 intersubunit interface [polypeptide binding]; other site 714962008987 active site 714962008988 Zn2+ binding site [ion binding]; other site 714962008989 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 714962008990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962008991 putative substrate translocation pore; other site 714962008992 L-fucose isomerase; Provisional; Region: fucI; PRK10991 714962008993 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 714962008994 hexamer (dimer of trimers) interface [polypeptide binding]; other site 714962008995 trimer interface [polypeptide binding]; other site 714962008996 substrate binding site [chemical binding]; other site 714962008997 Mn binding site [ion binding]; other site 714962008998 L-fuculokinase; Provisional; Region: PRK10331 714962008999 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 714962009000 nucleotide binding site [chemical binding]; other site 714962009001 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 714962009002 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 714962009003 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 714962009004 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 714962009005 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 714962009006 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 714962009007 hypothetical protein; Provisional; Region: PRK10873 714962009008 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 714962009009 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962009010 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 714962009011 dimerization interface [polypeptide binding]; other site 714962009012 substrate binding pocket [chemical binding]; other site 714962009013 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 714962009014 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 714962009015 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 714962009016 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714962009017 catalytic residue [active] 714962009018 CsdA-binding activator; Provisional; Region: PRK15019 714962009019 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 714962009020 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 714962009021 putative ATP binding site [chemical binding]; other site 714962009022 putative substrate interface [chemical binding]; other site 714962009023 murein transglycosylase A; Provisional; Region: mltA; PRK11162 714962009024 MltA specific insert domain; Region: MltA; pfam03562 714962009025 3D domain; Region: 3D; pfam06725 714962009026 Protein of unknown function (DUF770); Region: DUF770; pfam05591 714962009027 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 714962009028 Protein of unknown function (DUF877); Region: DUF877; pfam05943 714962009029 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 714962009030 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 714962009031 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 714962009032 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 714962009033 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 714962009034 ligand binding site [chemical binding]; other site 714962009035 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 714962009036 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 714962009037 Clp amino terminal domain; Region: Clp_N; pfam02861 714962009038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962009039 Walker A motif; other site 714962009040 ATP binding site [chemical binding]; other site 714962009041 Walker B motif; other site 714962009042 arginine finger; other site 714962009043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962009044 Walker A motif; other site 714962009045 ATP binding site [chemical binding]; other site 714962009046 Walker B motif; other site 714962009047 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 714962009048 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 714962009049 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 714962009050 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 714962009051 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 714962009052 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 714962009053 PGAP1-like protein; Region: PGAP1; pfam07819 714962009054 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 714962009055 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 714962009056 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 714962009057 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 714962009058 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 714962009059 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 714962009060 PAAR motif; Region: PAAR_motif; pfam05488 714962009061 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 714962009062 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 714962009063 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 714962009064 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 714962009065 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 714962009066 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 714962009067 ImpA domain protein; Region: DUF3702; pfam12486 714962009068 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 714962009069 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 714962009070 putative ligand binding site [chemical binding]; other site 714962009071 putative NAD binding site [chemical binding]; other site 714962009072 catalytic site [active] 714962009073 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 714962009074 putative active site [active] 714962009075 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 714962009076 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714962009077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962009078 homodimer interface [polypeptide binding]; other site 714962009079 catalytic residue [active] 714962009080 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 714962009081 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 714962009082 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714962009083 active site turn [active] 714962009084 phosphorylation site [posttranslational modification] 714962009085 CAT RNA binding domain; Region: CAT_RBD; pfam03123 714962009086 PRD domain; Region: PRD; pfam00874 714962009087 PRD domain; Region: PRD; pfam00874 714962009088 AMIN domain; Region: AMIN; pfam11741 714962009089 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 714962009090 active site 714962009091 metal binding site [ion binding]; metal-binding site 714962009092 N-acetylglutamate synthase; Validated; Region: PRK05279 714962009093 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 714962009094 putative feedback inhibition sensing region; other site 714962009095 putative nucleotide binding site [chemical binding]; other site 714962009096 putative substrate binding site [chemical binding]; other site 714962009097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714962009098 Coenzyme A binding pocket [chemical binding]; other site 714962009099 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 714962009100 AAA domain; Region: AAA_30; pfam13604 714962009101 Family description; Region: UvrD_C_2; pfam13538 714962009102 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 714962009103 protease3; Provisional; Region: PRK15101 714962009104 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 714962009105 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 714962009106 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 714962009107 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 714962009108 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 714962009109 hypothetical protein; Provisional; Region: PRK10332 714962009110 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 714962009111 hypothetical protein; Provisional; Region: PRK11521 714962009112 hypothetical protein; Provisional; Region: PRK10557 714962009113 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 714962009114 hypothetical protein; Provisional; Region: PRK10506 714962009115 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 714962009116 thymidylate synthase; Reviewed; Region: thyA; PRK01827 714962009117 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 714962009118 dimerization interface [polypeptide binding]; other site 714962009119 active site 714962009120 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 714962009121 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 714962009122 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 714962009123 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 714962009124 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 714962009125 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 714962009126 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 714962009127 putative active site [active] 714962009128 Ap4A binding site [chemical binding]; other site 714962009129 nudix motif; other site 714962009130 putative metal binding site [ion binding]; other site 714962009131 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 714962009132 putative DNA-binding cleft [nucleotide binding]; other site 714962009133 putative DNA clevage site; other site 714962009134 molecular lever; other site 714962009135 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 714962009136 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 714962009137 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714962009138 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714962009139 active site 714962009140 catalytic tetrad [active] 714962009141 lysophospholipid transporter LplT; Provisional; Region: PRK11195 714962009142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962009143 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 714962009144 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 714962009145 putative acyl-acceptor binding pocket; other site 714962009146 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 714962009147 acyl-activating enzyme (AAE) consensus motif; other site 714962009148 putative AMP binding site [chemical binding]; other site 714962009149 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 714962009150 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714962009151 DNA binding site [nucleotide binding] 714962009152 domain linker motif; other site 714962009153 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 714962009154 dimerization interface (closed form) [polypeptide binding]; other site 714962009155 ligand binding site [chemical binding]; other site 714962009156 diaminopimelate decarboxylase; Provisional; Region: PRK11165 714962009157 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 714962009158 active site 714962009159 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 714962009160 substrate binding site [chemical binding]; other site 714962009161 catalytic residues [active] 714962009162 dimer interface [polypeptide binding]; other site 714962009163 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 714962009164 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962009165 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714962009166 dimerization interface [polypeptide binding]; other site 714962009167 putative racemase; Provisional; Region: PRK10200 714962009168 aspartate racemase; Region: asp_race; TIGR00035 714962009169 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 714962009170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962009171 putative substrate translocation pore; other site 714962009172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962009173 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 714962009174 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 714962009175 NADP binding site [chemical binding]; other site 714962009176 homodimer interface [polypeptide binding]; other site 714962009177 active site 714962009178 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 714962009179 putative acyltransferase; Provisional; Region: PRK05790 714962009180 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 714962009181 dimer interface [polypeptide binding]; other site 714962009182 active site 714962009183 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 714962009184 serine transporter; Region: stp; TIGR00814 714962009185 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 714962009186 Peptidase family M23; Region: Peptidase_M23; pfam01551 714962009187 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 714962009188 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 714962009189 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 714962009190 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 714962009191 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 714962009192 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 714962009193 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 714962009194 catalytic loop [active] 714962009195 iron binding site [ion binding]; other site 714962009196 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 714962009197 GAF domain; Region: GAF; cl17456 714962009198 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 714962009199 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714962009200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962009201 Walker A motif; other site 714962009202 ATP binding site [chemical binding]; other site 714962009203 Walker B motif; other site 714962009204 arginine finger; other site 714962009205 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 714962009206 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 714962009207 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 714962009208 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 714962009209 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 714962009210 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 714962009211 catalytic residue [active] 714962009212 peptidase; Reviewed; Region: PRK13004 714962009213 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 714962009214 putative metal binding site [ion binding]; other site 714962009215 putative dimer interface [polypeptide binding]; other site 714962009216 D-hydantoinase; Region: D-hydantoinase; TIGR02033 714962009217 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 714962009218 tetramer interface [polypeptide binding]; other site 714962009219 active site 714962009220 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 714962009221 carbamate kinase; Reviewed; Region: PRK12686 714962009222 putative substrate binding site [chemical binding]; other site 714962009223 homodimer interface [polypeptide binding]; other site 714962009224 nucleotide binding site [chemical binding]; other site 714962009225 nucleotide binding site [chemical binding]; other site 714962009226 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 714962009227 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 714962009228 XdhC Rossmann domain; Region: XdhC_C; pfam13478 714962009229 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 714962009230 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 714962009231 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 714962009232 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 714962009233 Ligand binding site; other site 714962009234 metal-binding site 714962009235 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 714962009236 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 714962009237 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714962009238 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 714962009239 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 714962009240 active site 714962009241 putative substrate binding pocket [chemical binding]; other site 714962009242 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 714962009243 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 714962009244 putative hypoxanthine oxidase; Provisional; Region: PRK09800 714962009245 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 714962009246 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 714962009247 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 714962009248 uracil-xanthine permease; Region: ncs2; TIGR00801 714962009249 guanine deaminase; Provisional; Region: PRK09228 714962009250 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 714962009251 active site 714962009252 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 714962009253 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 714962009254 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 714962009255 4Fe-4S binding domain; Region: Fer4; pfam00037 714962009256 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 714962009257 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714962009258 xanthine permease; Region: pbuX; TIGR03173 714962009259 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 714962009260 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 714962009261 active site 714962009262 metal binding site [ion binding]; metal-binding site 714962009263 nudix motif; other site 714962009264 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 714962009265 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 714962009266 dimer interface [polypeptide binding]; other site 714962009267 putative anticodon binding site; other site 714962009268 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 714962009269 motif 1; other site 714962009270 active site 714962009271 motif 2; other site 714962009272 motif 3; other site 714962009273 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 714962009274 DHH family; Region: DHH; pfam01368 714962009275 DHHA1 domain; Region: DHHA1; pfam02272 714962009276 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 714962009277 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 714962009278 dimerization domain [polypeptide binding]; other site 714962009279 dimer interface [polypeptide binding]; other site 714962009280 catalytic residues [active] 714962009281 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 714962009282 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 714962009283 active site 714962009284 Int/Topo IB signature motif; other site 714962009285 flavodoxin FldB; Provisional; Region: PRK12359 714962009286 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 714962009287 hypothetical protein; Provisional; Region: PRK10878 714962009288 putative global regulator; Reviewed; Region: PRK09559 714962009289 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 714962009290 hemolysin; Provisional; Region: PRK15087 714962009291 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 714962009292 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 714962009293 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 714962009294 beta-galactosidase; Region: BGL; TIGR03356 714962009295 glycine dehydrogenase; Provisional; Region: PRK05367 714962009296 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 714962009297 tetramer interface [polypeptide binding]; other site 714962009298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962009299 catalytic residue [active] 714962009300 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 714962009301 tetramer interface [polypeptide binding]; other site 714962009302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962009303 catalytic residue [active] 714962009304 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 714962009305 lipoyl attachment site [posttranslational modification]; other site 714962009306 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 714962009307 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 714962009308 oxidoreductase; Provisional; Region: PRK08013 714962009309 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 714962009310 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 714962009311 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 714962009312 proline aminopeptidase P II; Provisional; Region: PRK10879 714962009313 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 714962009314 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 714962009315 active site 714962009316 hypothetical protein; Reviewed; Region: PRK01736 714962009317 Z-ring-associated protein; Provisional; Region: PRK10972 714962009318 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 714962009319 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 714962009320 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 714962009321 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 714962009322 ligand binding site [chemical binding]; other site 714962009323 NAD binding site [chemical binding]; other site 714962009324 tetramer interface [polypeptide binding]; other site 714962009325 catalytic site [active] 714962009326 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 714962009327 L-serine binding site [chemical binding]; other site 714962009328 ACT domain interface; other site 714962009329 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 714962009330 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714962009331 active site 714962009332 dimer interface [polypeptide binding]; other site 714962009333 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714962009334 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 714962009335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962009336 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 714962009337 putative dimerization interface [polypeptide binding]; other site 714962009338 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 714962009339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962009340 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714962009341 Uncharacterized conserved protein [Function unknown]; Region: COG2968 714962009342 oxidative stress defense protein; Provisional; Region: PRK11087 714962009343 arginine exporter protein; Provisional; Region: PRK09304 714962009344 mechanosensitive channel MscS; Provisional; Region: PRK10334 714962009345 Mechanosensitive ion channel; Region: MS_channel; pfam00924 714962009346 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 714962009347 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 714962009348 active site 714962009349 intersubunit interface [polypeptide binding]; other site 714962009350 zinc binding site [ion binding]; other site 714962009351 Na+ binding site [ion binding]; other site 714962009352 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 714962009353 Phosphoglycerate kinase; Region: PGK; pfam00162 714962009354 substrate binding site [chemical binding]; other site 714962009355 hinge regions; other site 714962009356 ADP binding site [chemical binding]; other site 714962009357 catalytic site [active] 714962009358 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 714962009359 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 714962009360 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 714962009361 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 714962009362 trimer interface [polypeptide binding]; other site 714962009363 putative Zn binding site [ion binding]; other site 714962009364 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 714962009365 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 714962009366 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 714962009367 Walker A/P-loop; other site 714962009368 ATP binding site [chemical binding]; other site 714962009369 Q-loop/lid; other site 714962009370 ABC transporter signature motif; other site 714962009371 Walker B; other site 714962009372 D-loop; other site 714962009373 H-loop/switch region; other site 714962009374 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 714962009375 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 714962009376 Walker A/P-loop; other site 714962009377 ATP binding site [chemical binding]; other site 714962009378 Q-loop/lid; other site 714962009379 ABC transporter signature motif; other site 714962009380 Walker B; other site 714962009381 D-loop; other site 714962009382 H-loop/switch region; other site 714962009383 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 714962009384 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 714962009385 active site 714962009386 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 714962009387 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 714962009388 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 714962009389 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 714962009390 putative NAD(P) binding site [chemical binding]; other site 714962009391 catalytic Zn binding site [ion binding]; other site 714962009392 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 714962009393 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 714962009394 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 714962009395 active site 714962009396 P-loop; other site 714962009397 phosphorylation site [posttranslational modification] 714962009398 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 714962009399 active site 714962009400 phosphorylation site [posttranslational modification] 714962009401 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 714962009402 SPFH domain / Band 7 family; Region: Band_7; pfam01145 714962009403 transketolase; Reviewed; Region: PRK12753 714962009404 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 714962009405 TPP-binding site [chemical binding]; other site 714962009406 dimer interface [polypeptide binding]; other site 714962009407 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 714962009408 PYR/PP interface [polypeptide binding]; other site 714962009409 dimer interface [polypeptide binding]; other site 714962009410 TPP binding site [chemical binding]; other site 714962009411 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 714962009412 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 714962009413 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 714962009414 agmatinase; Region: agmatinase; TIGR01230 714962009415 oligomer interface [polypeptide binding]; other site 714962009416 putative active site [active] 714962009417 Mn binding site [ion binding]; other site 714962009418 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 714962009419 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 714962009420 dimer interface [polypeptide binding]; other site 714962009421 active site 714962009422 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 714962009423 catalytic residues [active] 714962009424 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 714962009425 Virulence promoting factor; Region: YqgB; pfam11036 714962009426 S-adenosylmethionine synthetase; Validated; Region: PRK05250 714962009427 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 714962009428 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 714962009429 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 714962009430 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 714962009431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962009432 putative substrate translocation pore; other site 714962009433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962009434 hypothetical protein; Provisional; Region: PRK04860 714962009435 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 714962009436 DNA-specific endonuclease I; Provisional; Region: PRK15137 714962009437 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 714962009438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 714962009439 RNA methyltransferase, RsmE family; Region: TIGR00046 714962009440 glutathione synthetase; Provisional; Region: PRK05246 714962009441 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 714962009442 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 714962009443 hypothetical protein; Validated; Region: PRK00228 714962009444 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 714962009445 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 714962009446 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 714962009447 Walker A motif; other site 714962009448 ATP binding site [chemical binding]; other site 714962009449 Walker B motif; other site 714962009450 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 714962009451 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 714962009452 catalytic residue [active] 714962009453 YGGT family; Region: YGGT; pfam02325 714962009454 YGGT family; Region: YGGT; pfam02325 714962009455 hypothetical protein; Validated; Region: PRK05090 714962009456 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 714962009457 active site 714962009458 dimerization interface [polypeptide binding]; other site 714962009459 HemN family oxidoreductase; Provisional; Region: PRK05660 714962009460 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714962009461 FeS/SAM binding site; other site 714962009462 HemN C-terminal domain; Region: HemN_C; pfam06969 714962009463 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 714962009464 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 714962009465 homodimer interface [polypeptide binding]; other site 714962009466 active site 714962009467 hypothetical protein; Provisional; Region: PRK10626 714962009468 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 714962009469 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 714962009470 hypothetical protein; Provisional; Region: PRK11702 714962009471 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 714962009472 adenine DNA glycosylase; Provisional; Region: PRK10880 714962009473 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 714962009474 minor groove reading motif; other site 714962009475 helix-hairpin-helix signature motif; other site 714962009476 substrate binding pocket [chemical binding]; other site 714962009477 active site 714962009478 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 714962009479 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 714962009480 DNA binding and oxoG recognition site [nucleotide binding] 714962009481 oxidative damage protection protein; Provisional; Region: PRK05408 714962009482 murein transglycosylase C; Provisional; Region: mltC; PRK11671 714962009483 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 714962009484 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 714962009485 N-acetyl-D-glucosamine binding site [chemical binding]; other site 714962009486 catalytic residue [active] 714962009487 nucleoside transporter; Region: 2A0110; TIGR00889 714962009488 ornithine decarboxylase; Provisional; Region: PRK13578 714962009489 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 714962009490 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 714962009491 homodimer interface [polypeptide binding]; other site 714962009492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962009493 catalytic residue [active] 714962009494 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 714962009495 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 714962009496 KpsF/GutQ family protein; Region: kpsF; TIGR00393 714962009497 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 714962009498 putative active site [active] 714962009499 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 714962009500 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 714962009501 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 714962009502 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 714962009503 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 714962009504 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 714962009505 Ligand binding site; other site 714962009506 oligomer interface; other site 714962009507 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 714962009508 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 714962009509 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 714962009510 Alpha-2,8-polysialyltransferase (POLYST); Region: A-2_8-polyST; pfam07388 714962009511 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 714962009512 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 714962009513 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 714962009514 active site 714962009515 homodimer interface [polypeptide binding]; other site 714962009516 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 714962009517 ligand binding site; other site 714962009518 tetramer interface; other site 714962009519 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 714962009520 active site 714962009521 catalytic triad [active] 714962009522 oxyanion hole [active] 714962009523 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 714962009524 NeuB family; Region: NeuB; pfam03102 714962009525 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 714962009526 NeuB binding interface [polypeptide binding]; other site 714962009527 putative substrate binding site [chemical binding]; other site 714962009528 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714962009529 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 714962009530 Walker A/P-loop; other site 714962009531 ATP binding site [chemical binding]; other site 714962009532 Q-loop/lid; other site 714962009533 ABC transporter signature motif; other site 714962009534 Walker B; other site 714962009535 D-loop; other site 714962009536 H-loop/switch region; other site 714962009537 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 714962009538 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 714962009539 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 714962009540 GspL-like protein; Provisional; Region: PRK09662 714962009541 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 714962009542 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 714962009543 type II secretion system protein J; Region: gspJ; TIGR01711 714962009544 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 714962009545 type II secretion system protein I; Region: gspI; TIGR01707 714962009546 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 714962009547 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 714962009548 Type II transport protein GspH; Region: GspH; pfam12019 714962009549 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 714962009550 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 714962009551 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 714962009552 type II secretion system protein F; Region: GspF; TIGR02120 714962009553 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 714962009554 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 714962009555 type II secretion system protein E; Region: type_II_gspE; TIGR02533 714962009556 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 714962009557 Walker A motif; other site 714962009558 ATP binding site [chemical binding]; other site 714962009559 Walker B motif; other site 714962009560 type II secretion system protein D; Region: type_II_gspD; TIGR02517 714962009561 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 714962009562 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 714962009563 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 714962009564 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 714962009565 putative type II secretion protein GspC; Provisional; Region: PRK09681 714962009566 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 714962009567 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 714962009568 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 714962009569 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 714962009570 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 714962009571 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 714962009572 Peptidase M60-like family; Region: M60-like; pfam13402 714962009573 glycolate transporter; Provisional; Region: PRK09695 714962009574 L-lactate permease; Region: Lactate_perm; cl00701 714962009575 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 714962009576 active site 714962009577 Domain of unknown function (DUF336); Region: DUF336; cl01249 714962009578 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 714962009579 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 714962009580 Cysteine-rich domain; Region: CCG; pfam02754 714962009581 Cysteine-rich domain; Region: CCG; pfam02754 714962009582 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 714962009583 FAD binding domain; Region: FAD_binding_4; pfam01565 714962009584 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 714962009585 FAD binding domain; Region: FAD_binding_4; pfam01565 714962009586 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 714962009587 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962009588 DNA-binding site [nucleotide binding]; DNA binding site 714962009589 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 714962009590 acyl-CoA synthetase; Validated; Region: PRK09192 714962009591 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 714962009592 acyl-activating enzyme (AAE) consensus motif; other site 714962009593 active site 714962009594 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 714962009595 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714962009596 NAD(P) binding site [chemical binding]; other site 714962009597 active site 714962009598 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 714962009599 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 714962009600 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 714962009601 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714962009602 catalytic residue [active] 714962009603 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 714962009604 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 714962009605 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 714962009606 Predicted permeases [General function prediction only]; Region: COG0795 714962009607 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 714962009608 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 714962009609 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 714962009610 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 714962009611 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 714962009612 active site 714962009613 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 714962009614 TMP-binding site; other site 714962009615 ATP-binding site [chemical binding]; other site 714962009616 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 714962009617 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 714962009618 TMP-binding site; other site 714962009619 ATP-binding site [chemical binding]; other site 714962009620 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 714962009621 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 714962009622 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 714962009623 CHAP domain; Region: CHAP; pfam05257 714962009624 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 714962009625 putative S-transferase; Provisional; Region: PRK11752 714962009626 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 714962009627 C-terminal domain interface [polypeptide binding]; other site 714962009628 GSH binding site (G-site) [chemical binding]; other site 714962009629 dimer interface [polypeptide binding]; other site 714962009630 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 714962009631 dimer interface [polypeptide binding]; other site 714962009632 N-terminal domain interface [polypeptide binding]; other site 714962009633 active site 714962009634 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 714962009635 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 714962009636 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 714962009637 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 714962009638 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 714962009639 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 714962009640 putative substrate-binding site; other site 714962009641 nickel binding site [ion binding]; other site 714962009642 hydrogenase 2 large subunit; Provisional; Region: PRK10467 714962009643 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 714962009644 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 714962009645 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 714962009646 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 714962009647 4Fe-4S binding domain; Region: Fer4_6; pfam12837 714962009648 hydrogenase 2 small subunit; Provisional; Region: PRK10468 714962009649 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 714962009650 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 714962009651 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 714962009652 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 714962009653 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 714962009654 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714962009655 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714962009656 active site 714962009657 catalytic tetrad [active] 714962009658 hypothetical protein; Provisional; Region: PRK05208 714962009659 oxidoreductase; Provisional; Region: PRK07985 714962009660 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 714962009661 NAD binding site [chemical binding]; other site 714962009662 metal binding site [ion binding]; metal-binding site 714962009663 active site 714962009664 biopolymer transport protein ExbD; Provisional; Region: PRK11267 714962009665 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 714962009666 biopolymer transport protein ExbB; Provisional; Region: PRK10414 714962009667 cystathionine beta-lyase; Provisional; Region: PRK08114 714962009668 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 714962009669 homodimer interface [polypeptide binding]; other site 714962009670 substrate-cofactor binding pocket; other site 714962009671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962009672 catalytic residue [active] 714962009673 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 714962009674 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 714962009675 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 714962009676 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 714962009677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962009678 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962009679 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 714962009680 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 714962009681 dimer interface [polypeptide binding]; other site 714962009682 active site 714962009683 metal binding site [ion binding]; metal-binding site 714962009684 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714962009685 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 714962009686 active site 714962009687 catalytic tetrad [active] 714962009688 putative outer membrane lipoprotein; Provisional; Region: PRK09973 714962009689 hypothetical protein; Provisional; Region: PRK01254 714962009690 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 714962009691 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 714962009692 Transcriptional regulators [Transcription]; Region: FadR; COG2186 714962009693 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962009694 DNA-binding site [nucleotide binding]; DNA binding site 714962009695 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 714962009696 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 714962009697 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 714962009698 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 714962009699 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 714962009700 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 714962009701 putative NAD(P) binding site [chemical binding]; other site 714962009702 catalytic Zn binding site [ion binding]; other site 714962009703 structural Zn binding site [ion binding]; other site 714962009704 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 714962009705 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 714962009706 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 714962009707 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 714962009708 DctM-like transporters; Region: DctM; pfam06808 714962009709 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 714962009710 FtsI repressor; Provisional; Region: PRK10883 714962009711 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 714962009712 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 714962009713 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 714962009714 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 714962009715 putative acyl-acceptor binding pocket; other site 714962009716 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 714962009717 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 714962009718 CAP-like domain; other site 714962009719 active site 714962009720 primary dimer interface [polypeptide binding]; other site 714962009721 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714962009722 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 714962009723 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714962009724 peptide binding site [polypeptide binding]; other site 714962009725 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 714962009726 TIGR00156 family protein; Region: TIGR00156 714962009727 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 714962009728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962009729 active site 714962009730 phosphorylation site [posttranslational modification] 714962009731 intermolecular recognition site; other site 714962009732 dimerization interface [polypeptide binding]; other site 714962009733 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714962009734 DNA binding site [nucleotide binding] 714962009735 sensor protein QseC; Provisional; Region: PRK10337 714962009736 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962009737 dimer interface [polypeptide binding]; other site 714962009738 phosphorylation site [posttranslational modification] 714962009739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962009740 ATP binding site [chemical binding]; other site 714962009741 Mg2+ binding site [ion binding]; other site 714962009742 G-X-G motif; other site 714962009743 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 714962009744 Uncharacterized conserved protein [Function unknown]; Region: COG1359 714962009745 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 714962009746 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 714962009747 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 714962009748 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 714962009749 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 714962009750 siderophore binding site; other site 714962009751 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 714962009752 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714962009753 ABC-ATPase subunit interface; other site 714962009754 dimer interface [polypeptide binding]; other site 714962009755 putative PBP binding regions; other site 714962009756 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 714962009757 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714962009758 dimer interface [polypeptide binding]; other site 714962009759 putative PBP binding regions; other site 714962009760 ABC-ATPase subunit interface; other site 714962009761 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 714962009762 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 714962009763 Walker A/P-loop; other site 714962009764 ATP binding site [chemical binding]; other site 714962009765 Q-loop/lid; other site 714962009766 ABC transporter signature motif; other site 714962009767 Walker B; other site 714962009768 D-loop; other site 714962009769 H-loop/switch region; other site 714962009770 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 714962009771 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 714962009772 N-terminal plug; other site 714962009773 ligand-binding site [chemical binding]; other site 714962009774 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 714962009775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962009776 ATP binding site [chemical binding]; other site 714962009777 Mg2+ binding site [ion binding]; other site 714962009778 G-X-G motif; other site 714962009779 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 714962009780 anchoring element; other site 714962009781 dimer interface [polypeptide binding]; other site 714962009782 ATP binding site [chemical binding]; other site 714962009783 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 714962009784 active site 714962009785 metal binding site [ion binding]; metal-binding site 714962009786 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 714962009787 esterase YqiA; Provisional; Region: PRK11071 714962009788 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714962009789 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 714962009790 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714962009791 active site 714962009792 metal binding site [ion binding]; metal-binding site 714962009793 hexamer interface [polypeptide binding]; other site 714962009794 putative dehydrogenase; Provisional; Region: PRK11039 714962009795 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 714962009796 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 714962009797 dimer interface [polypeptide binding]; other site 714962009798 ADP-ribose binding site [chemical binding]; other site 714962009799 active site 714962009800 nudix motif; other site 714962009801 metal binding site [ion binding]; metal-binding site 714962009802 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 714962009803 hypothetical protein; Provisional; Region: PRK11653 714962009804 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 714962009805 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 714962009806 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 714962009807 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 714962009808 catalytic residues [active] 714962009809 hinge region; other site 714962009810 alpha helical domain; other site 714962009811 putative disulfide oxidoreductase; Provisional; Region: PRK04307 714962009812 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 714962009813 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 714962009814 putative active site [active] 714962009815 metal binding site [ion binding]; metal-binding site 714962009816 zinc transporter ZupT; Provisional; Region: PRK04201 714962009817 ZIP Zinc transporter; Region: Zip; pfam02535 714962009818 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 714962009819 putative fimbrial protein; Provisional; Region: PRK09733 714962009820 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 714962009821 PapC N-terminal domain; Region: PapC_N; pfam13954 714962009822 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 714962009823 PapC C-terminal domain; Region: PapC_C; pfam13953 714962009824 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 714962009825 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 714962009826 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 714962009827 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 714962009828 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 714962009829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 714962009830 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 714962009831 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 714962009832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 714962009833 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 714962009834 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 714962009835 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 714962009836 putative ribose interaction site [chemical binding]; other site 714962009837 putative ADP binding site [chemical binding]; other site 714962009838 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 714962009839 active site 714962009840 nucleotide binding site [chemical binding]; other site 714962009841 HIGH motif; other site 714962009842 KMSKS motif; other site 714962009843 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 714962009844 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 714962009845 metal binding triad; other site 714962009846 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 714962009847 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 714962009848 metal binding triad; other site 714962009849 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 714962009850 Uncharacterized conserved protein [Function unknown]; Region: COG3025 714962009851 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 714962009852 putative active site [active] 714962009853 putative metal binding residues [ion binding]; other site 714962009854 signature motif; other site 714962009855 putative triphosphate binding site [ion binding]; other site 714962009856 CHAD domain; Region: CHAD; pfam05235 714962009857 SH3 domain-containing protein; Provisional; Region: PRK10884 714962009858 Bacterial SH3 domain homologues; Region: SH3b; smart00287 714962009859 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 714962009860 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 714962009861 active site 714962009862 NTP binding site [chemical binding]; other site 714962009863 metal binding triad [ion binding]; metal-binding site 714962009864 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 714962009865 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714962009866 Zn2+ binding site [ion binding]; other site 714962009867 Mg2+ binding site [ion binding]; other site 714962009868 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 714962009869 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 714962009870 homooctamer interface [polypeptide binding]; other site 714962009871 active site 714962009872 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 714962009873 transcriptional activator TtdR; Provisional; Region: PRK09801 714962009874 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962009875 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 714962009876 putative effector binding pocket; other site 714962009877 putative dimerization interface [polypeptide binding]; other site 714962009878 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 714962009879 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 714962009880 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 714962009881 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 714962009882 transmembrane helices; other site 714962009883 UGMP family protein; Validated; Region: PRK09604 714962009884 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 714962009885 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 714962009886 DNA primase; Validated; Region: dnaG; PRK05667 714962009887 CHC2 zinc finger; Region: zf-CHC2; pfam01807 714962009888 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 714962009889 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 714962009890 active site 714962009891 metal binding site [ion binding]; metal-binding site 714962009892 interdomain interaction site; other site 714962009893 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 714962009894 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 714962009895 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 714962009896 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 714962009897 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 714962009898 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 714962009899 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714962009900 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 714962009901 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714962009902 DNA binding residues [nucleotide binding] 714962009903 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 714962009904 active site 714962009905 SUMO-1 interface [polypeptide binding]; other site 714962009906 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 714962009907 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 714962009908 FAD binding pocket [chemical binding]; other site 714962009909 FAD binding motif [chemical binding]; other site 714962009910 phosphate binding motif [ion binding]; other site 714962009911 NAD binding pocket [chemical binding]; other site 714962009912 Predicted transcriptional regulators [Transcription]; Region: COG1695 714962009913 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 714962009914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714962009915 PAS fold; Region: PAS_3; pfam08447 714962009916 putative active site [active] 714962009917 heme pocket [chemical binding]; other site 714962009918 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 714962009919 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714962009920 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714962009921 dimer interface [polypeptide binding]; other site 714962009922 putative CheW interface [polypeptide binding]; other site 714962009923 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 714962009924 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714962009925 inhibitor-cofactor binding pocket; inhibition site 714962009926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962009927 catalytic residue [active] 714962009928 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 714962009929 dimer interface [polypeptide binding]; other site 714962009930 putative tRNA-binding site [nucleotide binding]; other site 714962009931 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 714962009932 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714962009933 DNA binding site [nucleotide binding] 714962009934 domain linker motif; other site 714962009935 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 714962009936 putative dimerization interface [polypeptide binding]; other site 714962009937 putative ligand binding site [chemical binding]; other site 714962009938 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 714962009939 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 714962009940 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 714962009941 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 714962009942 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 714962009943 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 714962009944 inner membrane transporter YjeM; Provisional; Region: PRK15238 714962009945 alpha-glucosidase; Provisional; Region: PRK10137 714962009946 Protein of unknown function, DUF608; Region: DUF608; pfam04685 714962009947 Trehalase; Region: Trehalase; cl17346 714962009948 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 714962009949 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 714962009950 active site 714962009951 FMN binding site [chemical binding]; other site 714962009952 2,4-decadienoyl-CoA binding site; other site 714962009953 catalytic residue [active] 714962009954 4Fe-4S cluster binding site [ion binding]; other site 714962009955 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 714962009956 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 714962009957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962009958 S-adenosylmethionine binding site [chemical binding]; other site 714962009959 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 714962009960 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 714962009961 putative active site [active] 714962009962 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 714962009963 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 714962009964 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 714962009965 serine/threonine transporter SstT; Provisional; Region: PRK13628 714962009966 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 714962009967 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 714962009968 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 714962009969 galactarate dehydratase; Region: galactar-dH20; TIGR03248 714962009970 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 714962009971 Glucuronate isomerase; Region: UxaC; pfam02614 714962009972 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 714962009973 D-galactonate transporter; Region: 2A0114; TIGR00893 714962009974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962009975 putative substrate translocation pore; other site 714962009976 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 714962009977 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962009978 DNA-binding site [nucleotide binding]; DNA binding site 714962009979 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 714962009980 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 714962009981 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 714962009982 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 714962009983 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 714962009984 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 714962009985 Predicted membrane protein [Function unknown]; Region: COG5393 714962009986 YqjK-like protein; Region: YqjK; pfam13997 714962009987 Predicted membrane protein [Function unknown]; Region: COG2259 714962009988 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 714962009989 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 714962009990 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 714962009991 putative dimer interface [polypeptide binding]; other site 714962009992 N-terminal domain interface [polypeptide binding]; other site 714962009993 putative substrate binding pocket (H-site) [chemical binding]; other site 714962009994 Predicted membrane protein [Function unknown]; Region: COG3152 714962009995 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962009996 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 714962009997 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714962009998 dimerization interface [polypeptide binding]; other site 714962009999 Pirin-related protein [General function prediction only]; Region: COG1741 714962010000 Pirin; Region: Pirin; pfam02678 714962010001 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 714962010002 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 714962010003 serine transporter; Region: stp; TIGR00814 714962010004 L-serine dehydratase TdcG; Provisional; Region: PRK15040 714962010005 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 714962010006 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 714962010007 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 714962010008 homotrimer interaction site [polypeptide binding]; other site 714962010009 putative active site [active] 714962010010 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 714962010011 Pyruvate formate lyase 1; Region: PFL1; cd01678 714962010012 coenzyme A binding site [chemical binding]; other site 714962010013 active site 714962010014 catalytic residues [active] 714962010015 glycine loop; other site 714962010016 propionate/acetate kinase; Provisional; Region: PRK12379 714962010017 Acetokinase family; Region: Acetate_kinase; cl17229 714962010018 threonine/serine transporter TdcC; Provisional; Region: PRK13629 714962010019 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 714962010020 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 714962010021 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 714962010022 tetramer interface [polypeptide binding]; other site 714962010023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962010024 catalytic residue [active] 714962010025 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 714962010026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962010027 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 714962010028 putative substrate binding pocket [chemical binding]; other site 714962010029 putative dimerization interface [polypeptide binding]; other site 714962010030 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 714962010031 glycerate kinase I; Provisional; Region: PRK10342 714962010032 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 714962010033 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 714962010034 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 714962010035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962010036 D-galactonate transporter; Region: 2A0114; TIGR00893 714962010037 putative substrate translocation pore; other site 714962010038 galactarate dehydratase; Region: galactar-dH20; TIGR03248 714962010039 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 714962010040 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 714962010041 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 714962010042 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 714962010043 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 714962010044 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 714962010045 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 714962010046 active site 714962010047 phosphorylation site [posttranslational modification] 714962010048 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 714962010049 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 714962010050 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 714962010051 active pocket/dimerization site; other site 714962010052 active site 714962010053 phosphorylation site [posttranslational modification] 714962010054 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 714962010055 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 714962010056 active site 714962010057 dimer interface [polypeptide binding]; other site 714962010058 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 714962010059 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 714962010060 dimer interface [polypeptide binding]; other site 714962010061 active site 714962010062 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 714962010063 putative active site [active] 714962010064 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 714962010065 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 714962010066 active site 714962010067 intersubunit interface [polypeptide binding]; other site 714962010068 zinc binding site [ion binding]; other site 714962010069 Na+ binding site [ion binding]; other site 714962010070 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 714962010071 active site 714962010072 phosphorylation site [posttranslational modification] 714962010073 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 714962010074 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 714962010075 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 714962010076 active site 714962010077 trimer interface [polypeptide binding]; other site 714962010078 allosteric site; other site 714962010079 active site lid [active] 714962010080 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 714962010081 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 714962010082 putative SAM binding site [chemical binding]; other site 714962010083 putative homodimer interface [polypeptide binding]; other site 714962010084 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 714962010085 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 714962010086 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 714962010087 putative ligand binding site [chemical binding]; other site 714962010088 TIGR00252 family protein; Region: TIGR00252 714962010089 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 714962010090 dimer interface [polypeptide binding]; other site 714962010091 active site 714962010092 outer membrane lipoprotein; Provisional; Region: PRK11023 714962010093 BON domain; Region: BON; pfam04972 714962010094 BON domain; Region: BON; pfam04972 714962010095 Predicted permease; Region: DUF318; pfam03773 714962010096 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 714962010097 NADH(P)-binding; Region: NAD_binding_10; pfam13460 714962010098 NAD binding site [chemical binding]; other site 714962010099 active site 714962010100 intracellular protease, PfpI family; Region: PfpI; TIGR01382 714962010101 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 714962010102 proposed catalytic triad [active] 714962010103 conserved cys residue [active] 714962010104 hypothetical protein; Provisional; Region: PRK03467 714962010105 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 714962010106 GIY-YIG motif/motif A; other site 714962010107 putative active site [active] 714962010108 putative metal binding site [ion binding]; other site 714962010109 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714962010110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714962010111 Coenzyme A binding pocket [chemical binding]; other site 714962010112 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 714962010113 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 714962010114 Peptidase family U32; Region: Peptidase_U32; pfam01136 714962010115 putative protease; Provisional; Region: PRK15447 714962010116 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 714962010117 hypothetical protein; Provisional; Region: PRK10508 714962010118 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 714962010119 tryptophan permease; Provisional; Region: PRK10483 714962010120 aromatic amino acid transport protein; Region: araaP; TIGR00837 714962010121 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 714962010122 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 714962010123 ATP binding site [chemical binding]; other site 714962010124 Mg++ binding site [ion binding]; other site 714962010125 motif III; other site 714962010126 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714962010127 nucleotide binding region [chemical binding]; other site 714962010128 ATP-binding site [chemical binding]; other site 714962010129 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 714962010130 putative RNA binding site [nucleotide binding]; other site 714962010131 lipoprotein NlpI; Provisional; Region: PRK11189 714962010132 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714962010133 binding surface 714962010134 TPR motif; other site 714962010135 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 714962010136 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 714962010137 RNase E interface [polypeptide binding]; other site 714962010138 trimer interface [polypeptide binding]; other site 714962010139 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 714962010140 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 714962010141 RNase E interface [polypeptide binding]; other site 714962010142 trimer interface [polypeptide binding]; other site 714962010143 active site 714962010144 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 714962010145 putative nucleic acid binding region [nucleotide binding]; other site 714962010146 G-X-X-G motif; other site 714962010147 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 714962010148 RNA binding site [nucleotide binding]; other site 714962010149 domain interface; other site 714962010150 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 714962010151 16S/18S rRNA binding site [nucleotide binding]; other site 714962010152 S13e-L30e interaction site [polypeptide binding]; other site 714962010153 25S rRNA binding site [nucleotide binding]; other site 714962010154 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 714962010155 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 714962010156 RNA binding site [nucleotide binding]; other site 714962010157 active site 714962010158 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 714962010159 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 714962010160 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 714962010161 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 714962010162 translation initiation factor IF-2; Region: IF-2; TIGR00487 714962010163 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 714962010164 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 714962010165 G1 box; other site 714962010166 putative GEF interaction site [polypeptide binding]; other site 714962010167 GTP/Mg2+ binding site [chemical binding]; other site 714962010168 Switch I region; other site 714962010169 G2 box; other site 714962010170 G3 box; other site 714962010171 Switch II region; other site 714962010172 G4 box; other site 714962010173 G5 box; other site 714962010174 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 714962010175 Translation-initiation factor 2; Region: IF-2; pfam11987 714962010176 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 714962010177 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 714962010178 NusA N-terminal domain; Region: NusA_N; pfam08529 714962010179 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 714962010180 RNA binding site [nucleotide binding]; other site 714962010181 homodimer interface [polypeptide binding]; other site 714962010182 NusA-like KH domain; Region: KH_5; pfam13184 714962010183 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 714962010184 G-X-X-G motif; other site 714962010185 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 714962010186 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 714962010187 ribosome maturation protein RimP; Reviewed; Region: PRK00092 714962010188 Sm and related proteins; Region: Sm_like; cl00259 714962010189 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 714962010190 putative oligomer interface [polypeptide binding]; other site 714962010191 putative RNA binding site [nucleotide binding]; other site 714962010192 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 714962010193 ANP binding site [chemical binding]; other site 714962010194 Substrate Binding Site II [chemical binding]; other site 714962010195 Substrate Binding Site I [chemical binding]; other site 714962010196 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 714962010197 Sulfatase; Region: Sulfatase; pfam00884 714962010198 Preprotein translocase SecG subunit; Region: SecG; pfam03840 714962010199 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 714962010200 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 714962010201 active site 714962010202 substrate binding site [chemical binding]; other site 714962010203 metal binding site [ion binding]; metal-binding site 714962010204 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 714962010205 dihydropteroate synthase; Region: DHPS; TIGR01496 714962010206 substrate binding pocket [chemical binding]; other site 714962010207 dimer interface [polypeptide binding]; other site 714962010208 inhibitor binding site; inhibition site 714962010209 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 714962010210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962010211 Walker A motif; other site 714962010212 ATP binding site [chemical binding]; other site 714962010213 Walker B motif; other site 714962010214 arginine finger; other site 714962010215 Peptidase family M41; Region: Peptidase_M41; pfam01434 714962010216 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 714962010217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962010218 S-adenosylmethionine binding site [chemical binding]; other site 714962010219 RNA-binding protein YhbY; Provisional; Region: PRK10343 714962010220 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 714962010221 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 714962010222 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 714962010223 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 714962010224 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 714962010225 GTPase CgtA; Reviewed; Region: obgE; PRK12298 714962010226 GTP1/OBG; Region: GTP1_OBG; pfam01018 714962010227 Obg GTPase; Region: Obg; cd01898 714962010228 G1 box; other site 714962010229 GTP/Mg2+ binding site [chemical binding]; other site 714962010230 Switch I region; other site 714962010231 G2 box; other site 714962010232 G3 box; other site 714962010233 Switch II region; other site 714962010234 G4 box; other site 714962010235 G5 box; other site 714962010236 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 714962010237 EamA-like transporter family; Region: EamA; pfam00892 714962010238 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 714962010239 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 714962010240 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 714962010241 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 714962010242 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 714962010243 substrate binding pocket [chemical binding]; other site 714962010244 chain length determination region; other site 714962010245 substrate-Mg2+ binding site; other site 714962010246 catalytic residues [active] 714962010247 aspartate-rich region 1; other site 714962010248 active site lid residues [active] 714962010249 aspartate-rich region 2; other site 714962010250 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 714962010251 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 714962010252 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 714962010253 hinge; other site 714962010254 active site 714962010255 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 714962010256 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 714962010257 anti sigma factor interaction site; other site 714962010258 regulatory phosphorylation site [posttranslational modification]; other site 714962010259 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 714962010260 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 714962010261 mce related protein; Region: MCE; pfam02470 714962010262 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 714962010263 conserved hypothetical integral membrane protein; Region: TIGR00056 714962010264 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 714962010265 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 714962010266 Walker A/P-loop; other site 714962010267 ATP binding site [chemical binding]; other site 714962010268 Q-loop/lid; other site 714962010269 ABC transporter signature motif; other site 714962010270 Walker B; other site 714962010271 D-loop; other site 714962010272 H-loop/switch region; other site 714962010273 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 714962010274 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 714962010275 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 714962010276 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 714962010277 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 714962010278 putative active site [active] 714962010279 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 714962010280 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 714962010281 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 714962010282 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 714962010283 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 714962010284 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 714962010285 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 714962010286 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 714962010287 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 714962010288 Walker A/P-loop; other site 714962010289 ATP binding site [chemical binding]; other site 714962010290 Q-loop/lid; other site 714962010291 ABC transporter signature motif; other site 714962010292 Walker B; other site 714962010293 D-loop; other site 714962010294 H-loop/switch region; other site 714962010295 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 714962010296 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 714962010297 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 714962010298 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 714962010299 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 714962010300 30S subunit binding site; other site 714962010301 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 714962010302 active site 714962010303 phosphorylation site [posttranslational modification] 714962010304 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 714962010305 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 714962010306 dimerization domain swap beta strand [polypeptide binding]; other site 714962010307 regulatory protein interface [polypeptide binding]; other site 714962010308 active site 714962010309 regulatory phosphorylation site [posttranslational modification]; other site 714962010310 hypothetical protein; Provisional; Region: PRK10345 714962010311 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 714962010312 Transglycosylase; Region: Transgly; cl17702 714962010313 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 714962010314 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 714962010315 conserved cys residue [active] 714962010316 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 714962010317 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714962010318 putative active site [active] 714962010319 heme pocket [chemical binding]; other site 714962010320 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962010321 dimer interface [polypeptide binding]; other site 714962010322 phosphorylation site [posttranslational modification] 714962010323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962010324 ATP binding site [chemical binding]; other site 714962010325 Mg2+ binding site [ion binding]; other site 714962010326 G-X-G motif; other site 714962010327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962010328 active site 714962010329 phosphorylation site [posttranslational modification] 714962010330 intermolecular recognition site; other site 714962010331 dimerization interface [polypeptide binding]; other site 714962010332 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 714962010333 putative binding surface; other site 714962010334 active site 714962010335 radical SAM protein, TIGR01212 family; Region: TIGR01212 714962010336 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714962010337 FeS/SAM binding site; other site 714962010338 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 714962010339 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 714962010340 active site 714962010341 dimer interface [polypeptide binding]; other site 714962010342 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 714962010343 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 714962010344 active site 714962010345 FMN binding site [chemical binding]; other site 714962010346 substrate binding site [chemical binding]; other site 714962010347 3Fe-4S cluster binding site [ion binding]; other site 714962010348 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 714962010349 domain interface; other site 714962010350 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 714962010351 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714962010352 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714962010353 Domain of unknown function (DUF386); Region: DUF386; cl01047 714962010354 N-acetylmannosamine kinase; Provisional; Region: PRK05082 714962010355 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 714962010356 nucleotide binding site [chemical binding]; other site 714962010357 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 714962010358 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 714962010359 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 714962010360 putative active site cavity [active] 714962010361 putative sialic acid transporter; Provisional; Region: PRK03893 714962010362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962010363 putative substrate translocation pore; other site 714962010364 N-acetylneuraminate lyase; Region: nanA; TIGR00683 714962010365 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 714962010366 inhibitor site; inhibition site 714962010367 active site 714962010368 dimer interface [polypeptide binding]; other site 714962010369 catalytic residue [active] 714962010370 transcriptional regulator NanR; Provisional; Region: PRK03837 714962010371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962010372 DNA-binding site [nucleotide binding]; DNA binding site 714962010373 FCD domain; Region: FCD; pfam07729 714962010374 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 714962010375 stringent starvation protein A; Provisional; Region: sspA; PRK09481 714962010376 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 714962010377 C-terminal domain interface [polypeptide binding]; other site 714962010378 putative GSH binding site (G-site) [chemical binding]; other site 714962010379 dimer interface [polypeptide binding]; other site 714962010380 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 714962010381 dimer interface [polypeptide binding]; other site 714962010382 N-terminal domain interface [polypeptide binding]; other site 714962010383 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 714962010384 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 714962010385 23S rRNA interface [nucleotide binding]; other site 714962010386 L3 interface [polypeptide binding]; other site 714962010387 Predicted ATPase [General function prediction only]; Region: COG1485 714962010388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 714962010389 hypothetical protein; Provisional; Region: PRK11677 714962010390 serine endoprotease; Provisional; Region: PRK10139 714962010391 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 714962010392 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 714962010393 protein binding site [polypeptide binding]; other site 714962010394 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 714962010395 serine endoprotease; Provisional; Region: PRK10898 714962010396 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 714962010397 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 714962010398 malate dehydrogenase; Provisional; Region: PRK05086 714962010399 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 714962010400 NAD binding site [chemical binding]; other site 714962010401 dimerization interface [polypeptide binding]; other site 714962010402 Substrate binding site [chemical binding]; other site 714962010403 arginine repressor; Provisional; Region: PRK05066 714962010404 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 714962010405 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 714962010406 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 714962010407 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 714962010408 RNAase interaction site [polypeptide binding]; other site 714962010409 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 714962010410 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 714962010411 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 714962010412 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 714962010413 HlyD family secretion protein; Region: HlyD_3; pfam13437 714962010414 efflux system membrane protein; Provisional; Region: PRK11594 714962010415 transcriptional regulator; Provisional; Region: PRK10632 714962010416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962010417 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 714962010418 putative effector binding pocket; other site 714962010419 dimerization interface [polypeptide binding]; other site 714962010420 protease TldD; Provisional; Region: tldD; PRK10735 714962010421 hypothetical protein; Provisional; Region: PRK10899 714962010422 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 714962010423 ribonuclease G; Provisional; Region: PRK11712 714962010424 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 714962010425 homodimer interface [polypeptide binding]; other site 714962010426 oligonucleotide binding site [chemical binding]; other site 714962010427 Maf-like protein; Region: Maf; pfam02545 714962010428 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 714962010429 active site 714962010430 dimer interface [polypeptide binding]; other site 714962010431 rod shape-determining protein MreD; Provisional; Region: PRK11060 714962010432 rod shape-determining protein MreC; Region: mreC; TIGR00219 714962010433 rod shape-determining protein MreC; Region: MreC; pfam04085 714962010434 rod shape-determining protein MreB; Provisional; Region: PRK13927 714962010435 MreB and similar proteins; Region: MreB_like; cd10225 714962010436 nucleotide binding site [chemical binding]; other site 714962010437 Mg binding site [ion binding]; other site 714962010438 putative protofilament interaction site [polypeptide binding]; other site 714962010439 RodZ interaction site [polypeptide binding]; other site 714962010440 regulatory protein CsrD; Provisional; Region: PRK11059 714962010441 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714962010442 metal binding site [ion binding]; metal-binding site 714962010443 active site 714962010444 I-site; other site 714962010445 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714962010446 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 714962010447 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 714962010448 NADP binding site [chemical binding]; other site 714962010449 dimer interface [polypeptide binding]; other site 714962010450 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 714962010451 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 714962010452 carboxyltransferase (CT) interaction site; other site 714962010453 biotinylation site [posttranslational modification]; other site 714962010454 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 714962010455 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 714962010456 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 714962010457 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 714962010458 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 714962010459 active site 714962010460 catalytic residues [active] 714962010461 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 714962010462 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 714962010463 substrate binding site [chemical binding]; other site 714962010464 ATP binding site [chemical binding]; other site 714962010465 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 714962010466 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 714962010467 TM-ABC transporter signature motif; other site 714962010468 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 714962010469 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 714962010470 Walker A/P-loop; other site 714962010471 ATP binding site [chemical binding]; other site 714962010472 Q-loop/lid; other site 714962010473 ABC transporter signature motif; other site 714962010474 Walker B; other site 714962010475 D-loop; other site 714962010476 H-loop/switch region; other site 714962010477 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 714962010478 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 714962010479 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 714962010480 putative ligand binding site [chemical binding]; other site 714962010481 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 714962010482 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 714962010483 intersubunit interface [polypeptide binding]; other site 714962010484 active site 714962010485 zinc binding site [ion binding]; other site 714962010486 Na+ binding site [ion binding]; other site 714962010487 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 714962010488 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 714962010489 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 714962010490 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 714962010491 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 714962010492 substrate binding site [chemical binding]; other site 714962010493 ATP binding site [chemical binding]; other site 714962010494 hypothetical protein; Provisional; Region: PRK10633 714962010495 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 714962010496 Na binding site [ion binding]; other site 714962010497 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 714962010498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 714962010499 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 714962010500 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 714962010501 FMN binding site [chemical binding]; other site 714962010502 active site 714962010503 catalytic residues [active] 714962010504 substrate binding site [chemical binding]; other site 714962010505 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 714962010506 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 714962010507 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 714962010508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962010509 DNA methylase; Region: N6_N4_Mtase; pfam01555 714962010510 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 714962010511 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 714962010512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714962010513 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 714962010514 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 714962010515 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 714962010516 HlyD family secretion protein; Region: HlyD_3; pfam13437 714962010517 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 714962010518 Protein export membrane protein; Region: SecD_SecF; cl14618 714962010519 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 714962010520 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 714962010521 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714962010522 substrate binding pocket [chemical binding]; other site 714962010523 membrane-bound complex binding site; other site 714962010524 hinge residues; other site 714962010525 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 714962010526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962010527 conserved gate region; other site 714962010528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962010529 dimer interface [polypeptide binding]; other site 714962010530 conserved gate region; other site 714962010531 putative PBP binding loops; other site 714962010532 ABC-ATPase subunit interface; other site 714962010533 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 714962010534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962010535 dimer interface [polypeptide binding]; other site 714962010536 conserved gate region; other site 714962010537 putative PBP binding loops; other site 714962010538 ABC-ATPase subunit interface; other site 714962010539 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 714962010540 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 714962010541 Walker A/P-loop; other site 714962010542 ATP binding site [chemical binding]; other site 714962010543 Q-loop/lid; other site 714962010544 ABC transporter signature motif; other site 714962010545 Walker B; other site 714962010546 D-loop; other site 714962010547 H-loop/switch region; other site 714962010548 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 714962010549 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 714962010550 trimer interface [polypeptide binding]; other site 714962010551 putative metal binding site [ion binding]; other site 714962010552 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 714962010553 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 714962010554 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 714962010555 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 714962010556 shikimate binding site; other site 714962010557 NAD(P) binding site [chemical binding]; other site 714962010558 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 714962010559 hypothetical protein; Validated; Region: PRK03430 714962010560 hypothetical protein; Provisional; Region: PRK10736 714962010561 DNA protecting protein DprA; Region: dprA; TIGR00732 714962010562 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 714962010563 active site 714962010564 catalytic residues [active] 714962010565 metal binding site [ion binding]; metal-binding site 714962010566 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 714962010567 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 714962010568 putative active site [active] 714962010569 substrate binding site [chemical binding]; other site 714962010570 putative cosubstrate binding site; other site 714962010571 catalytic site [active] 714962010572 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 714962010573 substrate binding site [chemical binding]; other site 714962010574 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 714962010575 putative RNA binding site [nucleotide binding]; other site 714962010576 16S rRNA methyltransferase B; Provisional; Region: PRK10901 714962010577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962010578 S-adenosylmethionine binding site [chemical binding]; other site 714962010579 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 714962010580 TrkA-N domain; Region: TrkA_N; pfam02254 714962010581 TrkA-C domain; Region: TrkA_C; pfam02080 714962010582 TrkA-N domain; Region: TrkA_N; pfam02254 714962010583 TrkA-C domain; Region: TrkA_C; pfam02080 714962010584 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 714962010585 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 714962010586 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 714962010587 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 714962010588 DNA binding residues [nucleotide binding] 714962010589 dimer interface [polypeptide binding]; other site 714962010590 metal binding site [ion binding]; metal-binding site 714962010591 hypothetical protein; Provisional; Region: PRK10203 714962010592 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 714962010593 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 714962010594 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 714962010595 alphaNTD homodimer interface [polypeptide binding]; other site 714962010596 alphaNTD - beta interaction site [polypeptide binding]; other site 714962010597 alphaNTD - beta' interaction site [polypeptide binding]; other site 714962010598 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 714962010599 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 714962010600 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 714962010601 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714962010602 RNA binding surface [nucleotide binding]; other site 714962010603 30S ribosomal protein S11; Validated; Region: PRK05309 714962010604 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 714962010605 30S ribosomal protein S13; Region: bact_S13; TIGR03631 714962010606 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 714962010607 SecY translocase; Region: SecY; pfam00344 714962010608 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 714962010609 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 714962010610 23S rRNA binding site [nucleotide binding]; other site 714962010611 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 714962010612 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 714962010613 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 714962010614 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 714962010615 23S rRNA interface [nucleotide binding]; other site 714962010616 5S rRNA interface [nucleotide binding]; other site 714962010617 L27 interface [polypeptide binding]; other site 714962010618 L5 interface [polypeptide binding]; other site 714962010619 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 714962010620 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 714962010621 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 714962010622 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 714962010623 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 714962010624 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 714962010625 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 714962010626 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 714962010627 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 714962010628 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 714962010629 RNA binding site [nucleotide binding]; other site 714962010630 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 714962010631 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 714962010632 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 714962010633 23S rRNA interface [nucleotide binding]; other site 714962010634 putative translocon interaction site; other site 714962010635 signal recognition particle (SRP54) interaction site; other site 714962010636 L23 interface [polypeptide binding]; other site 714962010637 trigger factor interaction site; other site 714962010638 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 714962010639 23S rRNA interface [nucleotide binding]; other site 714962010640 5S rRNA interface [nucleotide binding]; other site 714962010641 putative antibiotic binding site [chemical binding]; other site 714962010642 L25 interface [polypeptide binding]; other site 714962010643 L27 interface [polypeptide binding]; other site 714962010644 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 714962010645 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 714962010646 G-X-X-G motif; other site 714962010647 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 714962010648 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 714962010649 protein-rRNA interface [nucleotide binding]; other site 714962010650 putative translocon binding site; other site 714962010651 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 714962010652 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 714962010653 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 714962010654 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 714962010655 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 714962010656 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 714962010657 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 714962010658 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 714962010659 protein secretion protein GspB; Provisional; Region: PRK09697 714962010660 AAA domain; Region: AAA_22; pfam13401 714962010661 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 714962010662 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 714962010663 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 714962010664 type II secretion system protein D; Region: type_II_gspD; TIGR02517 714962010665 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 714962010666 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 714962010667 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 714962010668 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 714962010669 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 714962010670 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 714962010671 Walker A motif; other site 714962010672 ATP binding site [chemical binding]; other site 714962010673 Walker B motif; other site 714962010674 type II secretion system protein F; Region: GspF; TIGR02120 714962010675 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 714962010676 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 714962010677 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 714962010678 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 714962010679 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 714962010680 Type II transport protein GspH; Region: GspH; pfam12019 714962010681 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 714962010682 type II secretion system protein I; Region: gspI; TIGR01707 714962010683 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 714962010684 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 714962010685 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 714962010686 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 714962010687 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 714962010688 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 714962010689 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 714962010690 GspL periplasmic domain; Region: GspL_C; pfam12693 714962010691 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 714962010692 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 714962010693 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 714962010694 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 714962010695 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 714962010696 heme binding site [chemical binding]; other site 714962010697 ferroxidase pore; other site 714962010698 ferroxidase diiron center [ion binding]; other site 714962010699 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 714962010700 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 714962010701 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 714962010702 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 714962010703 aromatic chitin/cellulose binding site residues [chemical binding]; other site 714962010704 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 714962010705 active site 714962010706 elongation factor Tu; Reviewed; Region: PRK00049 714962010707 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 714962010708 G1 box; other site 714962010709 GEF interaction site [polypeptide binding]; other site 714962010710 GTP/Mg2+ binding site [chemical binding]; other site 714962010711 Switch I region; other site 714962010712 G2 box; other site 714962010713 G3 box; other site 714962010714 Switch II region; other site 714962010715 G4 box; other site 714962010716 G5 box; other site 714962010717 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 714962010718 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 714962010719 Antibiotic Binding Site [chemical binding]; other site 714962010720 elongation factor G; Reviewed; Region: PRK00007 714962010721 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 714962010722 G1 box; other site 714962010723 putative GEF interaction site [polypeptide binding]; other site 714962010724 GTP/Mg2+ binding site [chemical binding]; other site 714962010725 Switch I region; other site 714962010726 G2 box; other site 714962010727 G3 box; other site 714962010728 Switch II region; other site 714962010729 G4 box; other site 714962010730 G5 box; other site 714962010731 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 714962010732 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 714962010733 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 714962010734 30S ribosomal protein S7; Validated; Region: PRK05302 714962010735 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 714962010736 S17 interaction site [polypeptide binding]; other site 714962010737 S8 interaction site; other site 714962010738 16S rRNA interaction site [nucleotide binding]; other site 714962010739 streptomycin interaction site [chemical binding]; other site 714962010740 23S rRNA interaction site [nucleotide binding]; other site 714962010741 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 714962010742 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 714962010743 sulfur relay protein TusC; Validated; Region: PRK00211 714962010744 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 714962010745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 714962010746 YheO-like PAS domain; Region: PAS_6; pfam08348 714962010747 HTH domain; Region: HTH_22; pfam13309 714962010748 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 714962010749 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 714962010750 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 714962010751 phi X174 lysis protein; Provisional; Region: PRK02793 714962010752 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 714962010753 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 714962010754 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 714962010755 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 714962010756 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 714962010757 TrkA-N domain; Region: TrkA_N; pfam02254 714962010758 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 714962010759 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 714962010760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962010761 Walker A/P-loop; other site 714962010762 ATP binding site [chemical binding]; other site 714962010763 Q-loop/lid; other site 714962010764 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714962010765 ABC transporter signature motif; other site 714962010766 Walker B; other site 714962010767 D-loop; other site 714962010768 ABC transporter; Region: ABC_tran_2; pfam12848 714962010769 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714962010770 putative hydrolase; Provisional; Region: PRK10985 714962010771 hypothetical protein; Provisional; Region: PRK04966 714962010772 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 714962010773 active site 714962010774 hypothetical protein; Provisional; Region: PRK10738 714962010775 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 714962010776 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 714962010777 ligand binding site [chemical binding]; other site 714962010778 flexible hinge region; other site 714962010779 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 714962010780 putative switch regulator; other site 714962010781 non-specific DNA interactions [nucleotide binding]; other site 714962010782 DNA binding site [nucleotide binding] 714962010783 sequence specific DNA binding site [nucleotide binding]; other site 714962010784 putative cAMP binding site [chemical binding]; other site 714962010785 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 714962010786 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 714962010787 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 714962010788 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 714962010789 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714962010790 inhibitor-cofactor binding pocket; inhibition site 714962010791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962010792 catalytic residue [active] 714962010793 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 714962010794 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 714962010795 glutamine binding [chemical binding]; other site 714962010796 catalytic triad [active] 714962010797 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 714962010798 cell filamentation protein Fic; Provisional; Region: PRK10347 714962010799 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 714962010800 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 714962010801 substrate binding site [chemical binding]; other site 714962010802 putative transporter; Provisional; Region: PRK03699 714962010803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962010804 putative substrate translocation pore; other site 714962010805 nitrite reductase subunit NirD; Provisional; Region: PRK14989 714962010806 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714962010807 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 714962010808 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 714962010809 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 714962010810 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 714962010811 nitrite transporter NirC; Provisional; Region: PRK11562 714962010812 siroheme synthase; Provisional; Region: cysG; PRK10637 714962010813 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 714962010814 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 714962010815 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 714962010816 active site 714962010817 SAM binding site [chemical binding]; other site 714962010818 homodimer interface [polypeptide binding]; other site 714962010819 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 714962010820 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 714962010821 Protein of unknown function; Region: YhfT; pfam10797 714962010822 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 714962010823 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 714962010824 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 714962010825 active site 714962010826 substrate binding pocket [chemical binding]; other site 714962010827 homodimer interaction site [polypeptide binding]; other site 714962010828 putative mutase; Provisional; Region: PRK12383 714962010829 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 714962010830 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 714962010831 dimer interface [polypeptide binding]; other site 714962010832 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 714962010833 active site 714962010834 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 714962010835 substrate binding site [chemical binding]; other site 714962010836 catalytic residue [active] 714962010837 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 714962010838 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 714962010839 active site 714962010840 HIGH motif; other site 714962010841 dimer interface [polypeptide binding]; other site 714962010842 KMSKS motif; other site 714962010843 phosphoglycolate phosphatase; Provisional; Region: PRK13222 714962010844 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962010845 motif II; other site 714962010846 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 714962010847 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 714962010848 substrate binding site [chemical binding]; other site 714962010849 hexamer interface [polypeptide binding]; other site 714962010850 metal binding site [ion binding]; metal-binding site 714962010851 DNA adenine methylase; Provisional; Region: PRK10904 714962010852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 714962010853 cell division protein DamX; Validated; Region: PRK10905 714962010854 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 714962010855 active site 714962010856 dimer interface [polypeptide binding]; other site 714962010857 metal binding site [ion binding]; metal-binding site 714962010858 shikimate kinase; Reviewed; Region: aroK; PRK00131 714962010859 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 714962010860 ADP binding site [chemical binding]; other site 714962010861 magnesium binding site [ion binding]; other site 714962010862 putative shikimate binding site; other site 714962010863 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 714962010864 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 714962010865 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 714962010866 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 714962010867 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 714962010868 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 714962010869 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 714962010870 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 714962010871 Transglycosylase; Region: Transgly; pfam00912 714962010872 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 714962010873 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 714962010874 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 714962010875 ADP-ribose binding site [chemical binding]; other site 714962010876 dimer interface [polypeptide binding]; other site 714962010877 active site 714962010878 nudix motif; other site 714962010879 metal binding site [ion binding]; metal-binding site 714962010880 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 714962010881 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 714962010882 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962010883 motif II; other site 714962010884 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714962010885 RNA binding surface [nucleotide binding]; other site 714962010886 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 714962010887 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 714962010888 dimerization interface [polypeptide binding]; other site 714962010889 domain crossover interface; other site 714962010890 redox-dependent activation switch; other site 714962010891 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 714962010892 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 714962010893 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 714962010894 active site 714962010895 substrate-binding site [chemical binding]; other site 714962010896 metal-binding site [ion binding] 714962010897 ATP binding site [chemical binding]; other site 714962010898 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 714962010899 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714962010900 dimerization interface [polypeptide binding]; other site 714962010901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962010902 dimer interface [polypeptide binding]; other site 714962010903 phosphorylation site [posttranslational modification] 714962010904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962010905 ATP binding site [chemical binding]; other site 714962010906 G-X-G motif; other site 714962010907 osmolarity response regulator; Provisional; Region: ompR; PRK09468 714962010908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962010909 active site 714962010910 phosphorylation site [posttranslational modification] 714962010911 intermolecular recognition site; other site 714962010912 dimerization interface [polypeptide binding]; other site 714962010913 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714962010914 DNA binding site [nucleotide binding] 714962010915 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 714962010916 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 714962010917 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 714962010918 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 714962010919 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 714962010920 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 714962010921 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 714962010922 RNA binding site [nucleotide binding]; other site 714962010923 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 714962010924 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 714962010925 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 714962010926 G1 box; other site 714962010927 GTP/Mg2+ binding site [chemical binding]; other site 714962010928 Switch I region; other site 714962010929 G2 box; other site 714962010930 G3 box; other site 714962010931 Switch II region; other site 714962010932 G4 box; other site 714962010933 G5 box; other site 714962010934 Nucleoside recognition; Region: Gate; pfam07670 714962010935 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 714962010936 Nucleoside recognition; Region: Gate; pfam07670 714962010937 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 714962010938 carboxylesterase BioH; Provisional; Region: PRK10349 714962010939 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 714962010940 DNA utilization protein GntX; Provisional; Region: PRK11595 714962010941 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714962010942 active site 714962010943 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 714962010944 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 714962010945 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 714962010946 high-affinity gluconate transporter; Provisional; Region: PRK14984 714962010947 gluconate transporter; Region: gntP; TIGR00791 714962010948 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 714962010949 4-alpha-glucanotransferase; Region: malQ; TIGR00217 714962010950 maltodextrin phosphorylase; Provisional; Region: PRK14985 714962010951 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 714962010952 homodimer interface [polypeptide binding]; other site 714962010953 active site pocket [active] 714962010954 transcriptional regulator MalT; Provisional; Region: PRK04841 714962010955 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714962010956 DNA binding residues [nucleotide binding] 714962010957 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 714962010958 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 714962010959 putative active site [active] 714962010960 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 714962010961 hypothetical protein; Reviewed; Region: PRK09588 714962010962 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 714962010963 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 714962010964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962010965 Walker A motif; other site 714962010966 ATP binding site [chemical binding]; other site 714962010967 Walker B motif; other site 714962010968 arginine finger; other site 714962010969 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 714962010970 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 714962010971 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 714962010972 intramembrane serine protease GlpG; Provisional; Region: PRK10907 714962010973 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 714962010974 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 714962010975 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 714962010976 active site residue [active] 714962010977 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 714962010978 hypothetical protein; Provisional; Region: PRK09781; cl08057 714962010979 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 714962010980 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 714962010981 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 714962010982 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 714962010983 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 714962010984 outer membrane usher protein; Provisional; Region: PRK15193 714962010985 PapC N-terminal domain; Region: PapC_N; pfam13954 714962010986 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 714962010987 PapC C-terminal domain; Region: PapC_C; pfam13953 714962010988 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 714962010989 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 714962010990 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 714962010991 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 714962010992 glycogen phosphorylase; Provisional; Region: PRK14986 714962010993 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 714962010994 homodimer interface [polypeptide binding]; other site 714962010995 active site pocket [active] 714962010996 glycogen synthase; Provisional; Region: glgA; PRK00654 714962010997 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 714962010998 ADP-binding pocket [chemical binding]; other site 714962010999 homodimer interface [polypeptide binding]; other site 714962011000 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 714962011001 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 714962011002 ligand binding site; other site 714962011003 oligomer interface; other site 714962011004 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 714962011005 sulfate 1 binding site; other site 714962011006 glycogen debranching enzyme; Provisional; Region: PRK03705 714962011007 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 714962011008 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 714962011009 active site 714962011010 catalytic site [active] 714962011011 glycogen branching enzyme; Provisional; Region: PRK05402 714962011012 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 714962011013 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 714962011014 active site 714962011015 catalytic site [active] 714962011016 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 714962011017 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 714962011018 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 714962011019 putative antibiotic transporter; Provisional; Region: PRK10739 714962011020 low affinity gluconate transporter; Provisional; Region: PRK10472 714962011021 gluconate transporter; Region: gntP; TIGR00791 714962011022 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 714962011023 ATP-binding site [chemical binding]; other site 714962011024 Gluconate-6-phosphate binding site [chemical binding]; other site 714962011025 Shikimate kinase; Region: SKI; pfam01202 714962011026 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 714962011027 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714962011028 DNA binding site [nucleotide binding] 714962011029 domain linker motif; other site 714962011030 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 714962011031 putative ligand binding site [chemical binding]; other site 714962011032 putative dimerization interface [polypeptide binding]; other site 714962011033 Pirin-related protein [General function prediction only]; Region: COG1741 714962011034 Pirin; Region: Pirin; pfam02678 714962011035 putative oxidoreductase; Provisional; Region: PRK10206 714962011036 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 714962011037 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 714962011038 putative acetyltransferase YhhY; Provisional; Region: PRK10140 714962011039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714962011040 Coenzyme A binding pocket [chemical binding]; other site 714962011041 YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849 714962011042 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 714962011043 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 714962011044 hypothetical protein; Provisional; Region: PRK10350 714962011045 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 714962011046 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 714962011047 putative active site [active] 714962011048 catalytic site [active] 714962011049 putative metal binding site [ion binding]; other site 714962011050 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 714962011051 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 714962011052 Walker A/P-loop; other site 714962011053 ATP binding site [chemical binding]; other site 714962011054 Q-loop/lid; other site 714962011055 ABC transporter signature motif; other site 714962011056 Walker B; other site 714962011057 D-loop; other site 714962011058 H-loop/switch region; other site 714962011059 TOBE domain; Region: TOBE_2; pfam08402 714962011060 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 714962011061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962011062 dimer interface [polypeptide binding]; other site 714962011063 conserved gate region; other site 714962011064 putative PBP binding loops; other site 714962011065 ABC-ATPase subunit interface; other site 714962011066 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 714962011067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962011068 dimer interface [polypeptide binding]; other site 714962011069 conserved gate region; other site 714962011070 putative PBP binding loops; other site 714962011071 ABC-ATPase subunit interface; other site 714962011072 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 714962011073 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 714962011074 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 714962011075 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 714962011076 Walker A/P-loop; other site 714962011077 ATP binding site [chemical binding]; other site 714962011078 Q-loop/lid; other site 714962011079 ABC transporter signature motif; other site 714962011080 Walker B; other site 714962011081 D-loop; other site 714962011082 H-loop/switch region; other site 714962011083 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 714962011084 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 714962011085 Walker A/P-loop; other site 714962011086 ATP binding site [chemical binding]; other site 714962011087 Q-loop/lid; other site 714962011088 ABC transporter signature motif; other site 714962011089 Walker B; other site 714962011090 D-loop; other site 714962011091 H-loop/switch region; other site 714962011092 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 714962011093 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 714962011094 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 714962011095 TM-ABC transporter signature motif; other site 714962011096 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 714962011097 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 714962011098 TM-ABC transporter signature motif; other site 714962011099 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 714962011100 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 714962011101 dimerization interface [polypeptide binding]; other site 714962011102 ligand binding site [chemical binding]; other site 714962011103 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 714962011104 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 714962011105 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 714962011106 dimerization interface [polypeptide binding]; other site 714962011107 ligand binding site [chemical binding]; other site 714962011108 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 714962011109 active pocket/dimerization site; other site 714962011110 active site 714962011111 phosphorylation site [posttranslational modification] 714962011112 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 714962011113 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 714962011114 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 714962011115 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 714962011116 putative ligand binding site [chemical binding]; other site 714962011117 putative NAD binding site [chemical binding]; other site 714962011118 catalytic site [active] 714962011119 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 714962011120 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 714962011121 inhibitor site; inhibition site 714962011122 active site 714962011123 dimer interface [polypeptide binding]; other site 714962011124 catalytic residue [active] 714962011125 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 714962011126 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714962011127 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714962011128 DNA binding residues [nucleotide binding] 714962011129 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 714962011130 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 714962011131 cell division protein FtsE; Provisional; Region: PRK10908 714962011132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962011133 Walker A/P-loop; other site 714962011134 ATP binding site [chemical binding]; other site 714962011135 Q-loop/lid; other site 714962011136 ABC transporter signature motif; other site 714962011137 Walker B; other site 714962011138 D-loop; other site 714962011139 H-loop/switch region; other site 714962011140 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 714962011141 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 714962011142 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 714962011143 P loop; other site 714962011144 GTP binding site [chemical binding]; other site 714962011145 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 714962011146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962011147 S-adenosylmethionine binding site [chemical binding]; other site 714962011148 hypothetical protein; Provisional; Region: PRK10910 714962011149 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 714962011150 Predicted membrane protein [Function unknown]; Region: COG3714 714962011151 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 714962011152 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 714962011153 metal-binding site [ion binding] 714962011154 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714962011155 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 714962011156 CPxP motif; other site 714962011157 hypothetical protein; Provisional; Region: PRK11212 714962011158 hypothetical protein; Provisional; Region: PRK11615 714962011159 major facilitator superfamily transporter; Provisional; Region: PRK05122 714962011160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962011161 putative substrate translocation pore; other site 714962011162 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 714962011163 Domain of unknown function DUF20; Region: UPF0118; pfam01594 714962011164 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 714962011165 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 714962011166 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 714962011167 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 714962011168 substrate binding site [chemical binding]; other site 714962011169 nickel transporter permease NikB; Provisional; Region: PRK10352 714962011170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962011171 dimer interface [polypeptide binding]; other site 714962011172 conserved gate region; other site 714962011173 putative PBP binding loops; other site 714962011174 ABC-ATPase subunit interface; other site 714962011175 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 714962011176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962011177 dimer interface [polypeptide binding]; other site 714962011178 conserved gate region; other site 714962011179 putative PBP binding loops; other site 714962011180 ABC-ATPase subunit interface; other site 714962011181 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 714962011182 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714962011183 Walker A/P-loop; other site 714962011184 ATP binding site [chemical binding]; other site 714962011185 Q-loop/lid; other site 714962011186 ABC transporter signature motif; other site 714962011187 Walker B; other site 714962011188 D-loop; other site 714962011189 H-loop/switch region; other site 714962011190 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 714962011191 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 714962011192 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714962011193 Walker A/P-loop; other site 714962011194 ATP binding site [chemical binding]; other site 714962011195 Q-loop/lid; other site 714962011196 ABC transporter signature motif; other site 714962011197 Walker B; other site 714962011198 D-loop; other site 714962011199 H-loop/switch region; other site 714962011200 nickel responsive regulator; Provisional; Region: PRK02967 714962011201 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 714962011202 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 714962011203 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962011204 DNA-binding site [nucleotide binding]; DNA binding site 714962011205 UTRA domain; Region: UTRA; pfam07702 714962011206 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 714962011207 active site 714962011208 phosphorylation site [posttranslational modification] 714962011209 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 714962011210 active site 714962011211 P-loop; other site 714962011212 phosphorylation site [posttranslational modification] 714962011213 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 714962011214 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 714962011215 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 714962011216 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 714962011217 putative N- and C-terminal domain interface [polypeptide binding]; other site 714962011218 putative active site [active] 714962011219 putative MgATP binding site [chemical binding]; other site 714962011220 catalytic site [active] 714962011221 metal binding site [ion binding]; metal-binding site 714962011222 putative carbohydrate binding site [chemical binding]; other site 714962011223 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 714962011224 dimerization domain swap beta strand [polypeptide binding]; other site 714962011225 regulatory protein interface [polypeptide binding]; other site 714962011226 active site 714962011227 regulatory phosphorylation site [posttranslational modification]; other site 714962011228 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 714962011229 intersubunit interface [polypeptide binding]; other site 714962011230 active site 714962011231 zinc binding site [ion binding]; other site 714962011232 Na+ binding site [ion binding]; other site 714962011233 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 714962011234 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 714962011235 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 714962011236 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 714962011237 Walker A/P-loop; other site 714962011238 ATP binding site [chemical binding]; other site 714962011239 Q-loop/lid; other site 714962011240 ABC transporter signature motif; other site 714962011241 Walker B; other site 714962011242 D-loop; other site 714962011243 H-loop/switch region; other site 714962011244 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 714962011245 Walker A/P-loop; other site 714962011246 ATP binding site [chemical binding]; other site 714962011247 Q-loop/lid; other site 714962011248 ABC transporter signature motif; other site 714962011249 Walker B; other site 714962011250 D-loop; other site 714962011251 H-loop/switch region; other site 714962011252 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 714962011253 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 714962011254 HlyD family secretion protein; Region: HlyD; pfam00529 714962011255 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 714962011256 HlyD family secretion protein; Region: HlyD_3; pfam13437 714962011257 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 714962011258 Predicted flavoproteins [General function prediction only]; Region: COG2081 714962011259 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714962011260 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 714962011261 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 714962011262 universal stress protein UspB; Provisional; Region: PRK04960 714962011263 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 714962011264 Ligand Binding Site [chemical binding]; other site 714962011265 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 714962011266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962011267 POT family; Region: PTR2; pfam00854 714962011268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962011269 S-adenosylmethionine binding site [chemical binding]; other site 714962011270 oligopeptidase A; Provisional; Region: PRK10911 714962011271 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 714962011272 active site 714962011273 Zn binding site [ion binding]; other site 714962011274 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 714962011275 glutathione reductase; Validated; Region: PRK06116 714962011276 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714962011277 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714962011278 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 714962011279 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 714962011280 ArsC family; Region: ArsC; pfam03960 714962011281 catalytic residues [active] 714962011282 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 714962011283 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714962011284 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714962011285 DNA binding residues [nucleotide binding] 714962011286 dimerization interface [polypeptide binding]; other site 714962011287 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 714962011288 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 714962011289 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 714962011290 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 714962011291 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 714962011292 N-terminal plug; other site 714962011293 ligand-binding site [chemical binding]; other site 714962011294 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 714962011295 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 714962011296 putative hemin binding site; other site 714962011297 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 714962011298 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714962011299 FeS/SAM binding site; other site 714962011300 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 714962011301 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 714962011302 NADH(P)-binding; Region: NAD_binding_10; pfam13460 714962011303 NAD(P) binding site [chemical binding]; other site 714962011304 putative active site [active] 714962011305 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 714962011306 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714962011307 ABC-ATPase subunit interface; other site 714962011308 dimer interface [polypeptide binding]; other site 714962011309 putative PBP binding regions; other site 714962011310 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 714962011311 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 714962011312 Walker A/P-loop; other site 714962011313 ATP binding site [chemical binding]; other site 714962011314 Q-loop/lid; other site 714962011315 ABC transporter signature motif; other site 714962011316 Walker B; other site 714962011317 D-loop; other site 714962011318 H-loop/switch region; other site 714962011319 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 714962011320 MgtC family; Region: MgtC; pfam02308 714962011321 acid-resistance protein; Provisional; Region: hdeB; PRK11566 714962011322 acid-resistance protein; Provisional; Region: PRK10208 714962011323 acid-resistance membrane protein; Provisional; Region: PRK10209 714962011324 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 714962011325 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 714962011326 pyruvate kinase; Provisional; Region: PRK05826 714962011327 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 714962011328 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 714962011329 HlyD family secretion protein; Region: HlyD_3; pfam13437 714962011330 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 714962011331 Protein export membrane protein; Region: SecD_SecF; cl14618 714962011332 transcriptional regulator YdeO; Provisional; Region: PRK09940 714962011333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962011334 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 714962011335 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962011336 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 714962011337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962011338 catalytic residue [active] 714962011339 Haem-binding domain; Region: Haem_bd; pfam14376 714962011340 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 714962011341 trehalase; Provisional; Region: treF; PRK13270 714962011342 Trehalase; Region: Trehalase; pfam01204 714962011343 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714962011344 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714962011345 DNA binding residues [nucleotide binding] 714962011346 dimerization interface [polypeptide binding]; other site 714962011347 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714962011348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962011349 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 714962011350 putative effector binding pocket; other site 714962011351 putative dimerization interface [polypeptide binding]; other site 714962011352 inner membrane protein YhjD; Region: TIGR00766 714962011353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962011354 metabolite-proton symporter; Region: 2A0106; TIGR00883 714962011355 putative substrate translocation pore; other site 714962011356 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 714962011357 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 714962011358 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714962011359 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 714962011360 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 714962011361 substrate binding site [chemical binding]; other site 714962011362 ATP binding site [chemical binding]; other site 714962011363 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 714962011364 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 714962011365 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 714962011366 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 714962011367 putative diguanylate cyclase; Provisional; Region: PRK13561 714962011368 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714962011369 metal binding site [ion binding]; metal-binding site 714962011370 active site 714962011371 I-site; other site 714962011372 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714962011373 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 714962011374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714962011375 binding surface 714962011376 TPR motif; other site 714962011377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714962011378 binding surface 714962011379 TPR motif; other site 714962011380 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 714962011381 TPR motif; other site 714962011382 binding surface 714962011383 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 714962011384 endo-1,4-D-glucanase; Provisional; Region: PRK11097 714962011385 cellulose synthase regulator protein; Provisional; Region: PRK11114 714962011386 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 714962011387 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714962011388 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 714962011389 DXD motif; other site 714962011390 PilZ domain; Region: PilZ; pfam07238 714962011391 cell division protein; Provisional; Region: PRK10037 714962011392 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 714962011393 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 714962011394 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 714962011395 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 714962011396 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 714962011397 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 714962011398 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 714962011399 serine transporter; Region: stp; TIGR00814 714962011400 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 714962011401 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714962011402 Walker A/P-loop; other site 714962011403 ATP binding site [chemical binding]; other site 714962011404 Q-loop/lid; other site 714962011405 ABC transporter signature motif; other site 714962011406 Walker B; other site 714962011407 D-loop; other site 714962011408 H-loop/switch region; other site 714962011409 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 714962011410 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 714962011411 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714962011412 Walker A/P-loop; other site 714962011413 ATP binding site [chemical binding]; other site 714962011414 Q-loop/lid; other site 714962011415 ABC transporter signature motif; other site 714962011416 Walker B; other site 714962011417 D-loop; other site 714962011418 H-loop/switch region; other site 714962011419 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 714962011420 dipeptide transporter; Provisional; Region: PRK10913 714962011421 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 714962011422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962011423 dimer interface [polypeptide binding]; other site 714962011424 conserved gate region; other site 714962011425 putative PBP binding loops; other site 714962011426 ABC-ATPase subunit interface; other site 714962011427 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 714962011428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962011429 dimer interface [polypeptide binding]; other site 714962011430 conserved gate region; other site 714962011431 putative PBP binding loops; other site 714962011432 ABC-ATPase subunit interface; other site 714962011433 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 714962011434 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 714962011435 peptide binding site [polypeptide binding]; other site 714962011436 phosphoethanolamine transferase; Provisional; Region: PRK11560 714962011437 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 714962011438 Sulfatase; Region: Sulfatase; pfam00884 714962011439 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 714962011440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962011441 putative substrate translocation pore; other site 714962011442 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 714962011443 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 714962011444 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 714962011445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714962011446 Coenzyme A binding pocket [chemical binding]; other site 714962011447 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 714962011448 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 714962011449 molybdopterin cofactor binding site [chemical binding]; other site 714962011450 substrate binding site [chemical binding]; other site 714962011451 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 714962011452 molybdopterin cofactor binding site; other site 714962011453 putative outer membrane lipoprotein; Provisional; Region: PRK10510 714962011454 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 714962011455 ligand binding site [chemical binding]; other site 714962011456 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 714962011457 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 714962011458 dimerization interface [polypeptide binding]; other site 714962011459 ligand binding site [chemical binding]; other site 714962011460 NADP binding site [chemical binding]; other site 714962011461 catalytic site [active] 714962011462 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 714962011463 Predicted transcriptional regulator [Transcription]; Region: COG2944 714962011464 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714962011465 non-specific DNA binding site [nucleotide binding]; other site 714962011466 salt bridge; other site 714962011467 sequence-specific DNA binding site [nucleotide binding]; other site 714962011468 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 714962011469 DNA-binding site [nucleotide binding]; DNA binding site 714962011470 RNA-binding motif; other site 714962011471 small toxic polypeptide; Provisional; Region: PRK09759 714962011472 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 714962011473 DALR anticodon binding domain; Region: DALR_1; pfam05746 714962011474 anticodon binding site; other site 714962011475 tRNA binding surface [nucleotide binding]; other site 714962011476 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 714962011477 dimer interface [polypeptide binding]; other site 714962011478 motif 1; other site 714962011479 active site 714962011480 motif 2; other site 714962011481 motif 3; other site 714962011482 YsaB-like lipoprotein; Region: YsaB; pfam13983 714962011483 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 714962011484 Acyltransferase family; Region: Acyl_transf_3; pfam01757 714962011485 hypothetical protein; Provisional; Region: PRK11383 714962011486 yiaA/B two helix domain; Region: YiaAB; pfam05360 714962011487 yiaA/B two helix domain; Region: YiaAB; pfam05360 714962011488 hypothetical protein; Provisional; Region: PRK11403 714962011489 yiaA/B two helix domain; Region: YiaAB; pfam05360 714962011490 xylulokinase; Provisional; Region: PRK15027 714962011491 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 714962011492 N- and C-terminal domain interface [polypeptide binding]; other site 714962011493 active site 714962011494 MgATP binding site [chemical binding]; other site 714962011495 catalytic site [active] 714962011496 metal binding site [ion binding]; metal-binding site 714962011497 xylulose binding site [chemical binding]; other site 714962011498 homodimer interface [polypeptide binding]; other site 714962011499 xylose isomerase; Provisional; Region: PRK05474 714962011500 xylose isomerase; Region: xylose_isom_A; TIGR02630 714962011501 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 714962011502 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 714962011503 putative ligand binding site [chemical binding]; other site 714962011504 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 714962011505 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 714962011506 Walker A/P-loop; other site 714962011507 ATP binding site [chemical binding]; other site 714962011508 Q-loop/lid; other site 714962011509 ABC transporter signature motif; other site 714962011510 Walker B; other site 714962011511 D-loop; other site 714962011512 H-loop/switch region; other site 714962011513 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 714962011514 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 714962011515 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 714962011516 TM-ABC transporter signature motif; other site 714962011517 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 714962011518 putative dimerization interface [polypeptide binding]; other site 714962011519 Transcriptional regulators [Transcription]; Region: PurR; COG1609 714962011520 putative ligand binding site [chemical binding]; other site 714962011521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962011522 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714962011523 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962011524 hypothetical protein; Provisional; Region: PRK10356 714962011525 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 714962011526 alpha-amylase; Reviewed; Region: malS; PRK09505 714962011527 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 714962011528 active site 714962011529 catalytic site [active] 714962011530 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 714962011531 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714962011532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962011533 homodimer interface [polypeptide binding]; other site 714962011534 catalytic residue [active] 714962011535 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 714962011536 Transcriptional regulator [Transcription]; Region: IclR; COG1414 714962011537 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 714962011538 Bacterial transcriptional regulator; Region: IclR; pfam01614 714962011539 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 714962011540 Domain of unknown function (DUF386); Region: DUF386; pfam04074 714962011541 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 714962011542 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 714962011543 DctM-like transporters; Region: DctM; pfam06808 714962011544 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 714962011545 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 714962011546 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 714962011547 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 714962011548 putative N- and C-terminal domain interface [polypeptide binding]; other site 714962011549 putative active site [active] 714962011550 MgATP binding site [chemical binding]; other site 714962011551 catalytic site [active] 714962011552 metal binding site [ion binding]; metal-binding site 714962011553 putative xylulose binding site [chemical binding]; other site 714962011554 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 714962011555 active site 714962011556 dimer interface [polypeptide binding]; other site 714962011557 magnesium binding site [ion binding]; other site 714962011558 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 714962011559 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 714962011560 AP (apurinic/apyrimidinic) site pocket; other site 714962011561 DNA interaction; other site 714962011562 Metal-binding active site; metal-binding site 714962011563 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 714962011564 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 714962011565 intersubunit interface [polypeptide binding]; other site 714962011566 active site 714962011567 Zn2+ binding site [ion binding]; other site 714962011568 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 714962011569 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 714962011570 NAD(P) binding site [chemical binding]; other site 714962011571 catalytic residues [active] 714962011572 Fic family protein [Function unknown]; Region: COG3177 714962011573 Fic/DOC family; Region: Fic; pfam02661 714962011574 putative alcohol dehydrogenase; Provisional; Region: PRK09860 714962011575 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 714962011576 dimer interface [polypeptide binding]; other site 714962011577 active site 714962011578 metal binding site [ion binding]; metal-binding site 714962011579 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 714962011580 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 714962011581 G1 box; other site 714962011582 putative GEF interaction site [polypeptide binding]; other site 714962011583 GTP/Mg2+ binding site [chemical binding]; other site 714962011584 Switch I region; other site 714962011585 G2 box; other site 714962011586 G3 box; other site 714962011587 Switch II region; other site 714962011588 G4 box; other site 714962011589 G5 box; other site 714962011590 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 714962011591 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 714962011592 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 714962011593 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 714962011594 selenocysteine synthase; Provisional; Region: PRK04311 714962011595 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 714962011596 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 714962011597 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714962011598 catalytic residue [active] 714962011599 putative glutathione S-transferase; Provisional; Region: PRK10357 714962011600 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 714962011601 putative C-terminal domain interface [polypeptide binding]; other site 714962011602 putative GSH binding site (G-site) [chemical binding]; other site 714962011603 putative dimer interface [polypeptide binding]; other site 714962011604 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 714962011605 dimer interface [polypeptide binding]; other site 714962011606 N-terminal domain interface [polypeptide binding]; other site 714962011607 putative substrate binding pocket (H-site) [chemical binding]; other site 714962011608 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 714962011609 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 714962011610 HlyD family secretion protein; Region: HlyD_3; pfam13437 714962011611 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 714962011612 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 714962011613 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 714962011614 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 714962011615 active site 714962011616 P-loop; other site 714962011617 phosphorylation site [posttranslational modification] 714962011618 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 714962011619 active site 714962011620 phosphorylation site [posttranslational modification] 714962011621 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 714962011622 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 714962011623 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 714962011624 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 714962011625 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 714962011626 hypothetical protein; Provisional; Region: PRK11020 714962011627 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 714962011628 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 714962011629 trimer interface [polypeptide binding]; other site 714962011630 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 714962011631 trimer interface [polypeptide binding]; other site 714962011632 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 714962011633 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 714962011634 Haemagglutinin; Region: HIM; pfam05662 714962011635 Haemagglutinin; Region: HIM; pfam05662 714962011636 YadA-like C-terminal region; Region: YadA; pfam03895 714962011637 L-lactate permease; Provisional; Region: PRK10420 714962011638 glycolate transporter; Provisional; Region: PRK09695 714962011639 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 714962011640 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962011641 DNA-binding site [nucleotide binding]; DNA binding site 714962011642 FCD domain; Region: FCD; pfam07729 714962011643 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 714962011644 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 714962011645 active site 714962011646 substrate binding site [chemical binding]; other site 714962011647 FMN binding site [chemical binding]; other site 714962011648 putative catalytic residues [active] 714962011649 putative rRNA methylase; Provisional; Region: PRK10358 714962011650 serine acetyltransferase; Provisional; Region: cysE; PRK11132 714962011651 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 714962011652 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 714962011653 trimer interface [polypeptide binding]; other site 714962011654 active site 714962011655 substrate binding site [chemical binding]; other site 714962011656 CoA binding site [chemical binding]; other site 714962011657 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 714962011658 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 714962011659 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 714962011660 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 714962011661 SecA binding site; other site 714962011662 Preprotein binding site; other site 714962011663 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 714962011664 GSH binding site [chemical binding]; other site 714962011665 catalytic residues [active] 714962011666 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 714962011667 active site residue [active] 714962011668 phosphoglyceromutase; Provisional; Region: PRK05434 714962011669 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 714962011670 AmiB activator; Provisional; Region: PRK11637 714962011671 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 714962011672 Peptidase family M23; Region: Peptidase_M23; pfam01551 714962011673 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 714962011674 NodB motif; other site 714962011675 putative active site [active] 714962011676 putative catalytic site [active] 714962011677 Zn binding site [ion binding]; other site 714962011678 putative glycosyl transferase; Provisional; Region: PRK10073 714962011679 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 714962011680 active site 714962011681 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 714962011682 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 714962011683 NAD(P) binding site [chemical binding]; other site 714962011684 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 714962011685 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 714962011686 substrate-cofactor binding pocket; other site 714962011687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962011688 catalytic residue [active] 714962011689 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 714962011690 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 714962011691 NADP binding site [chemical binding]; other site 714962011692 homopentamer interface [polypeptide binding]; other site 714962011693 substrate binding site [chemical binding]; other site 714962011694 active site 714962011695 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 714962011696 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 714962011697 putative active site [active] 714962011698 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 714962011699 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 714962011700 putative active site [active] 714962011701 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 714962011702 O-Antigen ligase; Region: Wzy_C; pfam04932 714962011703 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 714962011704 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 714962011705 active site 714962011706 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 714962011707 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 714962011708 Ligand binding site; other site 714962011709 metal-binding site 714962011710 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 714962011711 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 714962011712 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 714962011713 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 714962011714 Ligand binding site; other site 714962011715 metal-binding site 714962011716 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 714962011717 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 714962011718 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 714962011719 Ligand binding site; other site 714962011720 metal-binding site 714962011721 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 714962011722 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 714962011723 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 714962011724 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 714962011725 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 714962011726 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 714962011727 putative active site [active] 714962011728 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 714962011729 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 714962011730 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 714962011731 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 714962011732 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 714962011733 active site 714962011734 (T/H)XGH motif; other site 714962011735 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 714962011736 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 714962011737 DNA binding site [nucleotide binding] 714962011738 catalytic residue [active] 714962011739 H2TH interface [polypeptide binding]; other site 714962011740 putative catalytic residues [active] 714962011741 turnover-facilitating residue; other site 714962011742 intercalation triad [nucleotide binding]; other site 714962011743 8OG recognition residue [nucleotide binding]; other site 714962011744 putative reading head residues; other site 714962011745 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 714962011746 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 714962011747 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 714962011748 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 714962011749 hypothetical protein; Reviewed; Region: PRK00024 714962011750 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 714962011751 MPN+ (JAMM) motif; other site 714962011752 Zinc-binding site [ion binding]; other site 714962011753 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 714962011754 Flavoprotein; Region: Flavoprotein; pfam02441 714962011755 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 714962011756 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 714962011757 trimer interface [polypeptide binding]; other site 714962011758 active site 714962011759 division inhibitor protein; Provisional; Region: slmA; PRK09480 714962011760 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714962011761 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 714962011762 active site 714962011763 ribonuclease PH; Reviewed; Region: rph; PRK00173 714962011764 Ribonuclease PH; Region: RNase_PH_bact; cd11362 714962011765 hexamer interface [polypeptide binding]; other site 714962011766 active site 714962011767 hypothetical protein; Provisional; Region: PRK11820 714962011768 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 714962011769 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 714962011770 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 714962011771 BRO family, N-terminal domain; Region: Bro-N; pfam02498 714962011772 Predicted membrane protein [Function unknown]; Region: COG2860 714962011773 UPF0126 domain; Region: UPF0126; pfam03458 714962011774 UPF0126 domain; Region: UPF0126; pfam03458 714962011775 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 714962011776 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 714962011777 nucleotide binding pocket [chemical binding]; other site 714962011778 K-X-D-G motif; other site 714962011779 catalytic site [active] 714962011780 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 714962011781 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 714962011782 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 714962011783 catalytic site [active] 714962011784 G-X2-G-X-G-K; other site 714962011785 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 714962011786 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 714962011787 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714962011788 Zn2+ binding site [ion binding]; other site 714962011789 Mg2+ binding site [ion binding]; other site 714962011790 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 714962011791 synthetase active site [active] 714962011792 NTP binding site [chemical binding]; other site 714962011793 metal binding site [ion binding]; metal-binding site 714962011794 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 714962011795 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 714962011796 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 714962011797 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 714962011798 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 714962011799 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 714962011800 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 714962011801 generic binding surface II; other site 714962011802 ssDNA binding site; other site 714962011803 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714962011804 ATP binding site [chemical binding]; other site 714962011805 putative Mg++ binding site [ion binding]; other site 714962011806 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714962011807 nucleotide binding region [chemical binding]; other site 714962011808 ATP-binding site [chemical binding]; other site 714962011809 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 714962011810 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 714962011811 AsmA family; Region: AsmA; pfam05170 714962011812 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 714962011813 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 714962011814 fructokinase; Reviewed; Region: PRK09557 714962011815 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 714962011816 nucleotide binding site [chemical binding]; other site 714962011817 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 714962011818 intersubunit interface [polypeptide binding]; other site 714962011819 active site 714962011820 zinc binding site [ion binding]; other site 714962011821 Na+ binding site [ion binding]; other site 714962011822 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 714962011823 intersubunit interface [polypeptide binding]; other site 714962011824 active site 714962011825 zinc binding site [ion binding]; other site 714962011826 Na+ binding site [ion binding]; other site 714962011827 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 714962011828 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 714962011829 active site 714962011830 P-loop; other site 714962011831 phosphorylation site [posttranslational modification] 714962011832 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 714962011833 active site 714962011834 phosphorylation site [posttranslational modification] 714962011835 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 714962011836 HTH domain; Region: HTH_11; pfam08279 714962011837 Mga helix-turn-helix domain; Region: Mga; pfam05043 714962011838 PRD domain; Region: PRD; pfam00874 714962011839 PRD domain; Region: PRD; pfam00874 714962011840 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 714962011841 active site 714962011842 P-loop; other site 714962011843 phosphorylation site [posttranslational modification] 714962011844 putative alpha-glucosidase; Provisional; Region: PRK10658 714962011845 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 714962011846 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 714962011847 active site 714962011848 homotrimer interface [polypeptide binding]; other site 714962011849 catalytic site [active] 714962011850 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 714962011851 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 714962011852 putative transporter; Provisional; Region: PRK11462 714962011853 Virulence protein [General function prediction only]; Region: COG3943 714962011854 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 714962011855 Virulence protein [General function prediction only]; Region: COG3943 714962011856 EamA-like transporter family; Region: EamA; pfam00892 714962011857 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714962011858 EamA-like transporter family; Region: EamA; pfam00892 714962011859 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 714962011860 lipoprotein, YaeC family; Region: TIGR00363 714962011861 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 714962011862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962011863 putative substrate translocation pore; other site 714962011864 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 714962011865 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 714962011866 cryptic adenine deaminase; Provisional; Region: PRK10027 714962011867 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 714962011868 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 714962011869 active site 714962011870 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 714962011871 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 714962011872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962011873 putative substrate translocation pore; other site 714962011874 regulatory protein UhpC; Provisional; Region: PRK11663 714962011875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962011876 putative substrate translocation pore; other site 714962011877 sensory histidine kinase UhpB; Provisional; Region: PRK11644 714962011878 MASE1; Region: MASE1; pfam05231 714962011879 Histidine kinase; Region: HisKA_3; pfam07730 714962011880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962011881 ATP binding site [chemical binding]; other site 714962011882 Mg2+ binding site [ion binding]; other site 714962011883 G-X-G motif; other site 714962011884 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 714962011885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962011886 active site 714962011887 phosphorylation site [posttranslational modification] 714962011888 intermolecular recognition site; other site 714962011889 dimerization interface [polypeptide binding]; other site 714962011890 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714962011891 DNA binding residues [nucleotide binding] 714962011892 dimerization interface [polypeptide binding]; other site 714962011893 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 714962011894 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 714962011895 putative valine binding site [chemical binding]; other site 714962011896 dimer interface [polypeptide binding]; other site 714962011897 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 714962011898 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 714962011899 PYR/PP interface [polypeptide binding]; other site 714962011900 dimer interface [polypeptide binding]; other site 714962011901 TPP binding site [chemical binding]; other site 714962011902 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 714962011903 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 714962011904 TPP-binding site [chemical binding]; other site 714962011905 dimer interface [polypeptide binding]; other site 714962011906 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 714962011907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962011908 putative substrate translocation pore; other site 714962011909 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 714962011910 Domain of unknown function (DUF202); Region: DUF202; pfam02656 714962011911 Predicted membrane protein [Function unknown]; Region: COG2149 714962011912 Sulfatase; Region: Sulfatase; cl17466 714962011913 putative transporter; Provisional; Region: PRK10484 714962011914 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 714962011915 Na binding site [ion binding]; other site 714962011916 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 714962011917 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962011918 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714962011919 putative transporter; Validated; Region: PRK03818 714962011920 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 714962011921 TrkA-C domain; Region: TrkA_C; pfam02080 714962011922 TrkA-C domain; Region: TrkA_C; pfam02080 714962011923 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 714962011924 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 714962011925 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 714962011926 putative dimer interface [polypeptide binding]; other site 714962011927 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 714962011928 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 714962011929 putative dimer interface [polypeptide binding]; other site 714962011930 hypothetical protein; Provisional; Region: PRK11616 714962011931 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 714962011932 putative oxidoreductase; Provisional; Region: PRK11445 714962011933 hypothetical protein; Provisional; Region: PRK07236 714962011934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962011935 D-galactonate transporter; Region: 2A0114; TIGR00893 714962011936 putative substrate translocation pore; other site 714962011937 galactonate dehydratase; Provisional; Region: PRK14017 714962011938 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 714962011939 putative active site pocket [active] 714962011940 putative metal binding site [ion binding]; other site 714962011941 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 714962011942 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 714962011943 Transcriptional regulators [Transcription]; Region: FadR; COG2186 714962011944 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962011945 DNA-binding site [nucleotide binding]; DNA binding site 714962011946 FCD domain; Region: FCD; pfam07729 714962011947 hypothetical protein; Provisional; Region: PRK10215 714962011948 sugar phosphate phosphatase; Provisional; Region: PRK10513 714962011949 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962011950 active site 714962011951 motif I; other site 714962011952 motif II; other site 714962011953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962011954 hypothetical protein; Provisional; Region: PRK11426 714962011955 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 714962011956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962011957 Mg2+ binding site [ion binding]; other site 714962011958 G-X-G motif; other site 714962011959 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 714962011960 anchoring element; other site 714962011961 dimer interface [polypeptide binding]; other site 714962011962 ATP binding site [chemical binding]; other site 714962011963 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 714962011964 active site 714962011965 putative metal-binding site [ion binding]; other site 714962011966 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 714962011967 recF protein; Region: recf; TIGR00611 714962011968 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962011969 Walker A/P-loop; other site 714962011970 ATP binding site [chemical binding]; other site 714962011971 Q-loop/lid; other site 714962011972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962011973 ABC transporter signature motif; other site 714962011974 Walker B; other site 714962011975 D-loop; other site 714962011976 H-loop/switch region; other site 714962011977 DNA polymerase III subunit beta; Validated; Region: PRK05643 714962011978 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 714962011979 putative DNA binding surface [nucleotide binding]; other site 714962011980 dimer interface [polypeptide binding]; other site 714962011981 beta-clamp/clamp loader binding surface; other site 714962011982 beta-clamp/translesion DNA polymerase binding surface; other site 714962011983 DnaA N-terminal domain; Region: DnaA_N; pfam11638 714962011984 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 714962011985 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962011986 Walker A motif; other site 714962011987 ATP binding site [chemical binding]; other site 714962011988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 714962011989 Walker B motif; other site 714962011990 arginine finger; other site 714962011991 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 714962011992 DnaA box-binding interface [nucleotide binding]; other site 714962011993 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 714962011994 ribonuclease P; Reviewed; Region: rnpA; PRK01732 714962011995 membrane protein insertase; Provisional; Region: PRK01318 714962011996 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 714962011997 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 714962011998 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 714962011999 trmE is a tRNA modification GTPase; Region: trmE; cd04164 714962012000 G1 box; other site 714962012001 GTP/Mg2+ binding site [chemical binding]; other site 714962012002 Switch I region; other site 714962012003 G2 box; other site 714962012004 Switch II region; other site 714962012005 G3 box; other site 714962012006 G4 box; other site 714962012007 G5 box; other site 714962012008 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 714962012009 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 714962012010 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 714962012011 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 714962012012 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714962012013 catalytic residue [active] 714962012014 tryptophan permease TnaB; Provisional; Region: PRK09664 714962012015 aromatic amino acid transport protein; Region: araaP; TIGR00837 714962012016 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 714962012017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962012018 putative substrate translocation pore; other site 714962012019 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 714962012020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962012021 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 714962012022 substrate binding pocket [chemical binding]; other site 714962012023 dimerization interface [polypeptide binding]; other site 714962012024 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 714962012025 Predicted flavoprotein [General function prediction only]; Region: COG0431 714962012026 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 714962012027 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 714962012028 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 714962012029 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962012030 active site 714962012031 motif I; other site 714962012032 motif II; other site 714962012033 putative inner membrane protein; Provisional; Region: PRK09823 714962012034 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 714962012035 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 714962012036 active site 714962012037 trimer interface [polypeptide binding]; other site 714962012038 allosteric site; other site 714962012039 active site lid [active] 714962012040 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 714962012041 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 714962012042 trimer interface; other site 714962012043 sugar binding site [chemical binding]; other site 714962012044 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 714962012045 beta-galactosidase; Region: BGL; TIGR03356 714962012046 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 714962012047 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714962012048 active site turn [active] 714962012049 phosphorylation site [posttranslational modification] 714962012050 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 714962012051 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 714962012052 HPr interaction site; other site 714962012053 glycerol kinase (GK) interaction site [polypeptide binding]; other site 714962012054 active site 714962012055 phosphorylation site [posttranslational modification] 714962012056 transcriptional antiterminator BglG; Provisional; Region: PRK09772 714962012057 CAT RNA binding domain; Region: CAT_RBD; pfam03123 714962012058 PRD domain; Region: PRD; pfam00874 714962012059 PRD domain; Region: PRD; pfam00874 714962012060 transcriptional regulator PhoU; Provisional; Region: PRK11115 714962012061 PhoU domain; Region: PhoU; pfam01895 714962012062 PhoU domain; Region: PhoU; pfam01895 714962012063 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 714962012064 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 714962012065 Walker A/P-loop; other site 714962012066 ATP binding site [chemical binding]; other site 714962012067 Q-loop/lid; other site 714962012068 ABC transporter signature motif; other site 714962012069 Walker B; other site 714962012070 D-loop; other site 714962012071 H-loop/switch region; other site 714962012072 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 714962012073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962012074 dimer interface [polypeptide binding]; other site 714962012075 conserved gate region; other site 714962012076 putative PBP binding loops; other site 714962012077 ABC-ATPase subunit interface; other site 714962012078 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 714962012079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962012080 dimer interface [polypeptide binding]; other site 714962012081 conserved gate region; other site 714962012082 putative PBP binding loops; other site 714962012083 ABC-ATPase subunit interface; other site 714962012084 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714962012085 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 714962012086 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 714962012087 glutaminase active site [active] 714962012088 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 714962012089 dimer interface [polypeptide binding]; other site 714962012090 active site 714962012091 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 714962012092 dimer interface [polypeptide binding]; other site 714962012093 active site 714962012094 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 714962012095 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 714962012096 Substrate binding site; other site 714962012097 Mg++ binding site; other site 714962012098 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 714962012099 active site 714962012100 substrate binding site [chemical binding]; other site 714962012101 CoA binding site [chemical binding]; other site 714962012102 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 714962012103 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 714962012104 gamma subunit interface [polypeptide binding]; other site 714962012105 epsilon subunit interface [polypeptide binding]; other site 714962012106 LBP interface [polypeptide binding]; other site 714962012107 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 714962012108 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 714962012109 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 714962012110 alpha subunit interaction interface [polypeptide binding]; other site 714962012111 Walker A motif; other site 714962012112 ATP binding site [chemical binding]; other site 714962012113 Walker B motif; other site 714962012114 inhibitor binding site; inhibition site 714962012115 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 714962012116 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 714962012117 core domain interface [polypeptide binding]; other site 714962012118 delta subunit interface [polypeptide binding]; other site 714962012119 epsilon subunit interface [polypeptide binding]; other site 714962012120 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 714962012121 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 714962012122 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 714962012123 beta subunit interaction interface [polypeptide binding]; other site 714962012124 Walker A motif; other site 714962012125 ATP binding site [chemical binding]; other site 714962012126 Walker B motif; other site 714962012127 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 714962012128 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 714962012129 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 714962012130 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 714962012131 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 714962012132 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 714962012133 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 714962012134 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 714962012135 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 714962012136 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 714962012137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962012138 S-adenosylmethionine binding site [chemical binding]; other site 714962012139 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 714962012140 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 714962012141 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 714962012142 FMN-binding protein MioC; Provisional; Region: PRK09004 714962012143 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 714962012144 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714962012145 putative DNA binding site [nucleotide binding]; other site 714962012146 putative Zn2+ binding site [ion binding]; other site 714962012147 AsnC family; Region: AsnC_trans_reg; pfam01037 714962012148 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 714962012149 dimer interface [polypeptide binding]; other site 714962012150 active site 714962012151 hypothetical protein; Provisional; Region: yieM; PRK10997 714962012152 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 714962012153 metal ion-dependent adhesion site (MIDAS); other site 714962012154 regulatory ATPase RavA; Provisional; Region: PRK13531 714962012155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962012156 Walker A motif; other site 714962012157 ATP binding site [chemical binding]; other site 714962012158 Walker B motif; other site 714962012159 arginine finger; other site 714962012160 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 714962012161 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 714962012162 potassium uptake protein; Region: kup; TIGR00794 714962012163 D-ribose pyranase; Provisional; Region: PRK11797 714962012164 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 714962012165 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 714962012166 Walker A/P-loop; other site 714962012167 ATP binding site [chemical binding]; other site 714962012168 Q-loop/lid; other site 714962012169 ABC transporter signature motif; other site 714962012170 Walker B; other site 714962012171 D-loop; other site 714962012172 H-loop/switch region; other site 714962012173 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 714962012174 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 714962012175 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 714962012176 TM-ABC transporter signature motif; other site 714962012177 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 714962012178 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 714962012179 ligand binding site [chemical binding]; other site 714962012180 dimerization interface [polypeptide binding]; other site 714962012181 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 714962012182 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 714962012183 substrate binding site [chemical binding]; other site 714962012184 dimer interface [polypeptide binding]; other site 714962012185 ATP binding site [chemical binding]; other site 714962012186 transcriptional repressor RbsR; Provisional; Region: PRK10423 714962012187 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714962012188 DNA binding site [nucleotide binding] 714962012189 domain linker motif; other site 714962012190 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 714962012191 dimerization interface [polypeptide binding]; other site 714962012192 ligand binding site [chemical binding]; other site 714962012193 Transcriptional regulators [Transcription]; Region: FadR; COG2186 714962012194 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962012195 DNA-binding site [nucleotide binding]; DNA binding site 714962012196 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 714962012197 transcriptional regulator HdfR; Provisional; Region: PRK03601 714962012198 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962012199 LysR substrate binding domain; Region: LysR_substrate; pfam03466 714962012200 dimerization interface [polypeptide binding]; other site 714962012201 hypothetical protein; Provisional; Region: PRK11027 714962012202 putative ATP-dependent protease; Provisional; Region: PRK09862 714962012203 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 714962012204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962012205 Walker A motif; other site 714962012206 ATP binding site [chemical binding]; other site 714962012207 Walker B motif; other site 714962012208 arginine finger; other site 714962012209 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 714962012210 ilvG operon leader peptide; Provisional; Region: PRK10424 714962012211 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 714962012212 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 714962012213 PYR/PP interface [polypeptide binding]; other site 714962012214 dimer interface [polypeptide binding]; other site 714962012215 TPP binding site [chemical binding]; other site 714962012216 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 714962012217 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 714962012218 TPP-binding site [chemical binding]; other site 714962012219 dimer interface [polypeptide binding]; other site 714962012220 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 714962012221 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 714962012222 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 714962012223 homodimer interface [polypeptide binding]; other site 714962012224 substrate-cofactor binding pocket; other site 714962012225 catalytic residue [active] 714962012226 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 714962012227 threonine dehydratase; Reviewed; Region: PRK09224 714962012228 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 714962012229 tetramer interface [polypeptide binding]; other site 714962012230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962012231 catalytic residue [active] 714962012232 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 714962012233 putative Ile/Val binding site [chemical binding]; other site 714962012234 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 714962012235 putative Ile/Val binding site [chemical binding]; other site 714962012236 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962012237 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 714962012238 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 714962012239 putative dimerization interface [polypeptide binding]; other site 714962012240 ketol-acid reductoisomerase; Validated; Region: PRK05225 714962012241 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 714962012242 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 714962012243 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 714962012244 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 714962012245 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 714962012246 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 714962012247 Part of AAA domain; Region: AAA_19; pfam13245 714962012248 Family description; Region: UvrD_C_2; pfam13538 714962012249 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 714962012250 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 714962012251 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 714962012252 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 714962012253 ATP binding site [chemical binding]; other site 714962012254 Mg++ binding site [ion binding]; other site 714962012255 motif III; other site 714962012256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714962012257 nucleotide binding region [chemical binding]; other site 714962012258 ATP-binding site [chemical binding]; other site 714962012259 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714962012260 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 714962012261 catalytic residues [active] 714962012262 putative rho operon leader peptide; Provisional; Region: PRK09979 714962012263 transcription termination factor Rho; Provisional; Region: rho; PRK09376 714962012264 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 714962012265 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 714962012266 RNA binding site [nucleotide binding]; other site 714962012267 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 714962012268 multimer interface [polypeptide binding]; other site 714962012269 Walker A motif; other site 714962012270 ATP binding site [chemical binding]; other site 714962012271 Walker B motif; other site 714962012272 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 714962012273 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 714962012274 Mg++ binding site [ion binding]; other site 714962012275 putative catalytic motif [active] 714962012276 substrate binding site [chemical binding]; other site 714962012277 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 714962012278 Chain length determinant protein; Region: Wzz; pfam02706 714962012279 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 714962012280 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 714962012281 active site 714962012282 homodimer interface [polypeptide binding]; other site 714962012283 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 714962012284 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 714962012285 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 714962012286 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 714962012287 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 714962012288 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 714962012289 NAD binding site [chemical binding]; other site 714962012290 substrate binding site [chemical binding]; other site 714962012291 homodimer interface [polypeptide binding]; other site 714962012292 active site 714962012293 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 714962012294 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 714962012295 substrate binding site; other site 714962012296 tetramer interface; other site 714962012297 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 714962012298 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 714962012299 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 714962012300 inhibitor-cofactor binding pocket; inhibition site 714962012301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962012302 catalytic residue [active] 714962012303 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 714962012304 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 714962012305 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 714962012306 putative common antigen polymerase; Provisional; Region: PRK02975 714962012307 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 714962012308 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 714962012309 putative transport protein YifK; Provisional; Region: PRK10746 714962012310 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 714962012311 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714962012312 FeS/SAM binding site; other site 714962012313 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 714962012314 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 714962012315 Sulfatase; Region: Sulfatase; pfam00884 714962012316 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 714962012317 HemY protein N-terminus; Region: HemY_N; pfam07219 714962012318 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 714962012319 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 714962012320 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 714962012321 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 714962012322 active site 714962012323 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 714962012324 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 714962012325 domain interfaces; other site 714962012326 active site 714962012327 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 714962012328 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 714962012329 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 714962012330 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 714962012331 putative iron binding site [ion binding]; other site 714962012332 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 714962012333 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 714962012334 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 714962012335 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 714962012336 hypothetical protein; Provisional; Region: PRK10963 714962012337 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 714962012338 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 714962012339 active site 714962012340 DNA binding site [nucleotide binding] 714962012341 Int/Topo IB signature motif; other site 714962012342 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 714962012343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962012344 motif II; other site 714962012345 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 714962012346 Part of AAA domain; Region: AAA_19; pfam13245 714962012347 Family description; Region: UvrD_C_2; pfam13538 714962012348 Uncharacterized conserved protein [Function unknown]; Region: COG1912 714962012349 Predicted periplasmic protein [Function unknown]; Region: COG3698 714962012350 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 714962012351 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 714962012352 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 714962012353 Cl binding site [ion binding]; other site 714962012354 oligomer interface [polypeptide binding]; other site 714962012355 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 714962012356 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 714962012357 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 714962012358 EamA-like transporter family; Region: EamA; cl17759 714962012359 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 714962012360 CoenzymeA binding site [chemical binding]; other site 714962012361 subunit interaction site [polypeptide binding]; other site 714962012362 PHB binding site; other site 714962012363 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 714962012364 dimerization interface [polypeptide binding]; other site 714962012365 substrate binding site [chemical binding]; other site 714962012366 active site 714962012367 calcium binding site [ion binding]; other site 714962012368 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 714962012369 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714962012370 ATP binding site [chemical binding]; other site 714962012371 putative Mg++ binding site [ion binding]; other site 714962012372 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714962012373 nucleotide binding region [chemical binding]; other site 714962012374 ATP-binding site [chemical binding]; other site 714962012375 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 714962012376 Helicase and RNase D C-terminal; Region: HRDC; smart00341 714962012377 threonine efflux system; Provisional; Region: PRK10229 714962012378 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 714962012379 lysophospholipase L2; Provisional; Region: PRK10749 714962012380 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 714962012381 putative hydrolase; Provisional; Region: PRK10976 714962012382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962012383 active site 714962012384 motif I; other site 714962012385 motif II; other site 714962012386 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962012387 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714962012388 EamA-like transporter family; Region: EamA; pfam00892 714962012389 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 714962012390 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 714962012391 THF binding site; other site 714962012392 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 714962012393 substrate binding site [chemical binding]; other site 714962012394 THF binding site; other site 714962012395 zinc-binding site [ion binding]; other site 714962012396 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 714962012397 tetramer interface [polypeptide binding]; other site 714962012398 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 714962012399 active site 714962012400 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 714962012401 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 714962012402 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714962012403 active site turn [active] 714962012404 phosphorylation site [posttranslational modification] 714962012405 transketolase; Reviewed; Region: PRK12753 714962012406 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 714962012407 TPP-binding site [chemical binding]; other site 714962012408 dimer interface [polypeptide binding]; other site 714962012409 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 714962012410 PYR/PP interface [polypeptide binding]; other site 714962012411 dimer interface [polypeptide binding]; other site 714962012412 TPP binding site [chemical binding]; other site 714962012413 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 714962012414 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 714962012415 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 714962012416 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 714962012417 putative active site [active] 714962012418 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 714962012419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962012420 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714962012421 dimerization interface [polypeptide binding]; other site 714962012422 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 714962012423 Na binding site [ion binding]; other site 714962012424 allophanate hydrolase; Provisional; Region: PRK08186 714962012425 carbamate kinase; Reviewed; Region: PRK12686 714962012426 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 714962012427 putative substrate binding site [chemical binding]; other site 714962012428 nucleotide binding site [chemical binding]; other site 714962012429 nucleotide binding site [chemical binding]; other site 714962012430 homodimer interface [polypeptide binding]; other site 714962012431 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 714962012432 CoA binding domain; Region: CoA_binding; pfam02629 714962012433 CoA-ligase; Region: Ligase_CoA; pfam00549 714962012434 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 714962012435 Isochorismatase family; Region: Isochorismatase; pfam00857 714962012436 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 714962012437 catalytic triad [active] 714962012438 conserved cis-peptide bond; other site 714962012439 Dienelactone hydrolase family; Region: DLH; pfam01738 714962012440 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 714962012441 uridine phosphorylase; Provisional; Region: PRK11178 714962012442 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 714962012443 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 714962012444 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 714962012445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 714962012446 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 714962012447 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 714962012448 active site 714962012449 intersubunit interface [polypeptide binding]; other site 714962012450 catalytic residue [active] 714962012451 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 714962012452 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 714962012453 Transcriptional regulator [Transcription]; Region: IclR; COG1414 714962012454 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 714962012455 Bacterial transcriptional regulator; Region: IclR; pfam01614 714962012456 DNA recombination protein RmuC; Provisional; Region: PRK10361 714962012457 RmuC family; Region: RmuC; pfam02646 714962012458 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 714962012459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962012460 S-adenosylmethionine binding site [chemical binding]; other site 714962012461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 714962012462 SCP-2 sterol transfer family; Region: SCP2; pfam02036 714962012463 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 714962012464 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 714962012465 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 714962012466 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 714962012467 sec-independent translocase; Provisional; Region: PRK01770 714962012468 sec-independent translocase; Provisional; Region: tatB; PRK00404 714962012469 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 714962012470 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 714962012471 active site 714962012472 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 714962012473 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 714962012474 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 714962012475 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 714962012476 FMN reductase; Validated; Region: fre; PRK08051 714962012477 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 714962012478 FAD binding pocket [chemical binding]; other site 714962012479 FAD binding motif [chemical binding]; other site 714962012480 phosphate binding motif [ion binding]; other site 714962012481 beta-alpha-beta structure motif; other site 714962012482 NAD binding pocket [chemical binding]; other site 714962012483 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 714962012484 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 714962012485 dimer interface [polypeptide binding]; other site 714962012486 active site 714962012487 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 714962012488 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 714962012489 substrate binding site [chemical binding]; other site 714962012490 oxyanion hole (OAH) forming residues; other site 714962012491 trimer interface [polypeptide binding]; other site 714962012492 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 714962012493 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 714962012494 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 714962012495 proline dipeptidase; Provisional; Region: PRK13607 714962012496 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 714962012497 active site 714962012498 hypothetical protein; Provisional; Region: PRK11568 714962012499 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 714962012500 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 714962012501 potassium transporter; Provisional; Region: PRK10750 714962012502 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 714962012503 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 714962012504 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 714962012505 Walker A motif; other site 714962012506 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 714962012507 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 714962012508 GTP binding site; other site 714962012509 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 714962012510 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 714962012511 serine/threonine protein kinase; Provisional; Region: PRK11768 714962012512 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 714962012513 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 714962012514 catalytic residues [active] 714962012515 hinge region; other site 714962012516 alpha helical domain; other site 714962012517 hypothetical protein; Provisional; Region: PRK11367 714962012518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 714962012519 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 714962012520 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 714962012521 putative acyl-acceptor binding pocket; other site 714962012522 DNA polymerase I; Provisional; Region: PRK05755 714962012523 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 714962012524 active site 714962012525 metal binding site 1 [ion binding]; metal-binding site 714962012526 putative 5' ssDNA interaction site; other site 714962012527 metal binding site 3; metal-binding site 714962012528 metal binding site 2 [ion binding]; metal-binding site 714962012529 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 714962012530 putative DNA binding site [nucleotide binding]; other site 714962012531 putative metal binding site [ion binding]; other site 714962012532 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 714962012533 active site 714962012534 catalytic site [active] 714962012535 substrate binding site [chemical binding]; other site 714962012536 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 714962012537 active site 714962012538 DNA binding site [nucleotide binding] 714962012539 catalytic site [active] 714962012540 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 714962012541 G1 box; other site 714962012542 GTP/Mg2+ binding site [chemical binding]; other site 714962012543 Switch I region; other site 714962012544 G2 box; other site 714962012545 G3 box; other site 714962012546 Switch II region; other site 714962012547 G4 box; other site 714962012548 G5 box; other site 714962012549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 714962012550 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 714962012551 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714962012552 FeS/SAM binding site; other site 714962012553 HemN C-terminal domain; Region: HemN_C; pfam06969 714962012554 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 714962012555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962012556 active site 714962012557 phosphorylation site [posttranslational modification] 714962012558 intermolecular recognition site; other site 714962012559 dimerization interface [polypeptide binding]; other site 714962012560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962012561 Walker A motif; other site 714962012562 ATP binding site [chemical binding]; other site 714962012563 Walker B motif; other site 714962012564 arginine finger; other site 714962012565 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 714962012566 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 714962012567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714962012568 putative active site [active] 714962012569 heme pocket [chemical binding]; other site 714962012570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962012571 dimer interface [polypeptide binding]; other site 714962012572 phosphorylation site [posttranslational modification] 714962012573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962012574 ATP binding site [chemical binding]; other site 714962012575 Mg2+ binding site [ion binding]; other site 714962012576 G-X-G motif; other site 714962012577 glutamine synthetase; Provisional; Region: glnA; PRK09469 714962012578 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 714962012579 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 714962012580 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 714962012581 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 714962012582 G1 box; other site 714962012583 putative GEF interaction site [polypeptide binding]; other site 714962012584 GTP/Mg2+ binding site [chemical binding]; other site 714962012585 Switch I region; other site 714962012586 G2 box; other site 714962012587 G3 box; other site 714962012588 Switch II region; other site 714962012589 G4 box; other site 714962012590 G5 box; other site 714962012591 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 714962012592 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 714962012593 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 714962012594 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 714962012595 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 714962012596 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 714962012597 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 714962012598 substrate binding site [chemical binding]; other site 714962012599 ATP binding site [chemical binding]; other site 714962012600 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 714962012601 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 714962012602 Class I aldolases; Region: Aldolase_Class_I; cl17187 714962012603 catalytic residue [active] 714962012604 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 714962012605 putative oxidoreductase; Provisional; Region: PRK10083 714962012606 NAD(P) binding site [chemical binding]; other site 714962012607 benzoate transport; Region: 2A0115; TIGR00895 714962012608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962012609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962012610 shikimate transporter; Provisional; Region: PRK09952 714962012611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962012612 putative substrate translocation pore; other site 714962012613 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 714962012614 active site 714962012615 catalytic residues [active] 714962012616 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 714962012617 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962012618 motif II; other site 714962012619 hypothetical protein; Reviewed; Region: PRK01637 714962012620 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 714962012621 putative active site [active] 714962012622 dimerization interface [polypeptide binding]; other site 714962012623 putative tRNAtyr binding site [nucleotide binding]; other site 714962012624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714962012625 Coenzyme A binding pocket [chemical binding]; other site 714962012626 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 714962012627 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 714962012628 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 714962012629 substrate binding pocket [chemical binding]; other site 714962012630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714962012631 non-specific DNA binding site [nucleotide binding]; other site 714962012632 salt bridge; other site 714962012633 sequence-specific DNA binding site [nucleotide binding]; other site 714962012634 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 714962012635 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 714962012636 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 714962012637 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 714962012638 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 714962012639 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 714962012640 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 714962012641 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 714962012642 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 714962012643 [4Fe-4S] binding site [ion binding]; other site 714962012644 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 714962012645 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 714962012646 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 714962012647 molybdopterin cofactor binding site; other site 714962012648 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 714962012649 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 714962012650 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 714962012651 intersubunit interface [polypeptide binding]; other site 714962012652 active site 714962012653 Zn2+ binding site [ion binding]; other site 714962012654 L-rhamnose isomerase; Provisional; Region: PRK01076 714962012655 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 714962012656 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 714962012657 N- and C-terminal domain interface [polypeptide binding]; other site 714962012658 active site 714962012659 putative catalytic site [active] 714962012660 metal binding site [ion binding]; metal-binding site 714962012661 ATP binding site [chemical binding]; other site 714962012662 rhamnulokinase; Provisional; Region: rhaB; PRK10640 714962012663 carbohydrate binding site [chemical binding]; other site 714962012664 transcriptional activator RhaS; Provisional; Region: PRK13503 714962012665 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 714962012666 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962012667 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962012668 transcriptional activator RhaR; Provisional; Region: PRK13500 714962012669 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 714962012670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962012671 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962012672 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 714962012673 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 714962012674 superoxide dismutase; Provisional; Region: PRK10925 714962012675 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 714962012676 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 714962012677 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 714962012678 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 714962012679 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 714962012680 MOSC domain; Region: MOSC; pfam03473 714962012681 3-alpha domain; Region: 3-alpha; pfam03475 714962012682 two-component sensor protein; Provisional; Region: cpxA; PRK09470 714962012683 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714962012684 dimerization interface [polypeptide binding]; other site 714962012685 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962012686 dimer interface [polypeptide binding]; other site 714962012687 phosphorylation site [posttranslational modification] 714962012688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962012689 ATP binding site [chemical binding]; other site 714962012690 Mg2+ binding site [ion binding]; other site 714962012691 G-X-G motif; other site 714962012692 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 714962012693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962012694 active site 714962012695 intermolecular recognition site; other site 714962012696 dimerization interface [polypeptide binding]; other site 714962012697 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714962012698 DNA binding site [nucleotide binding] 714962012699 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 714962012700 dimer interface [polypeptide binding]; other site 714962012701 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 714962012702 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 714962012703 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 714962012704 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 714962012705 active site 714962012706 ADP/pyrophosphate binding site [chemical binding]; other site 714962012707 dimerization interface [polypeptide binding]; other site 714962012708 allosteric effector site; other site 714962012709 fructose-1,6-bisphosphate binding site; other site 714962012710 sulfate transporter subunit; Provisional; Region: PRK10752 714962012711 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 714962012712 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 714962012713 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 714962012714 triosephosphate isomerase; Provisional; Region: PRK14567 714962012715 substrate binding site [chemical binding]; other site 714962012716 dimer interface [polypeptide binding]; other site 714962012717 catalytic triad [active] 714962012718 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 714962012719 Predicted membrane protein [Function unknown]; Region: COG3152 714962012720 hypothetical protein; Provisional; Region: PRK09981 714962012721 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 714962012722 Ligand Binding Site [chemical binding]; other site 714962012723 ferredoxin-NADP reductase; Provisional; Region: PRK10926 714962012724 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 714962012725 FAD binding pocket [chemical binding]; other site 714962012726 FAD binding motif [chemical binding]; other site 714962012727 phosphate binding motif [ion binding]; other site 714962012728 beta-alpha-beta structure motif; other site 714962012729 NAD binding pocket [chemical binding]; other site 714962012730 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 714962012731 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 714962012732 putative active site [active] 714962012733 glycerol kinase; Provisional; Region: glpK; PRK00047 714962012734 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 714962012735 N- and C-terminal domain interface [polypeptide binding]; other site 714962012736 active site 714962012737 MgATP binding site [chemical binding]; other site 714962012738 catalytic site [active] 714962012739 metal binding site [ion binding]; metal-binding site 714962012740 glycerol binding site [chemical binding]; other site 714962012741 homotetramer interface [polypeptide binding]; other site 714962012742 homodimer interface [polypeptide binding]; other site 714962012743 FBP binding site [chemical binding]; other site 714962012744 protein IIAGlc interface [polypeptide binding]; other site 714962012745 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 714962012746 amphipathic channel; other site 714962012747 Asn-Pro-Ala signature motifs; other site 714962012748 septal ring assembly protein ZapB; Provisional; Region: PRK15422 714962012749 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 714962012750 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 714962012751 UbiA prenyltransferase family; Region: UbiA; pfam01040 714962012752 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 714962012753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962012754 Walker A motif; other site 714962012755 ATP binding site [chemical binding]; other site 714962012756 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 714962012757 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 714962012758 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 714962012759 active site 714962012760 HslU subunit interaction site [polypeptide binding]; other site 714962012761 essential cell division protein FtsN; Provisional; Region: PRK10927 714962012762 cell division protein FtsN; Provisional; Region: PRK12757 714962012763 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714962012764 DNA binding site [nucleotide binding] 714962012765 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 714962012766 domain linker motif; other site 714962012767 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 714962012768 dimerization interface [polypeptide binding]; other site 714962012769 ligand binding site [chemical binding]; other site 714962012770 primosome assembly protein PriA; Validated; Region: PRK05580 714962012771 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714962012772 ATP binding site [chemical binding]; other site 714962012773 putative Mg++ binding site [ion binding]; other site 714962012774 helicase superfamily c-terminal domain; Region: HELICc; smart00490 714962012775 ATP-binding site [chemical binding]; other site 714962012776 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 714962012777 hypothetical protein; Provisional; Region: PRK10030 714962012778 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 714962012779 dimerization interface [polypeptide binding]; other site 714962012780 DNA binding site [nucleotide binding] 714962012781 corepressor binding sites; other site 714962012782 cystathionine gamma-synthase; Provisional; Region: PRK08045 714962012783 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 714962012784 homodimer interface [polypeptide binding]; other site 714962012785 substrate-cofactor binding pocket; other site 714962012786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962012787 catalytic residue [active] 714962012788 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 714962012789 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 714962012790 putative catalytic residues [active] 714962012791 putative nucleotide binding site [chemical binding]; other site 714962012792 putative aspartate binding site [chemical binding]; other site 714962012793 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 714962012794 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 714962012795 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 714962012796 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 714962012797 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 714962012798 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 714962012799 active site 714962012800 metal binding site [ion binding]; metal-binding site 714962012801 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 714962012802 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 714962012803 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 714962012804 active site 714962012805 metal binding site [ion binding]; metal-binding site 714962012806 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 714962012807 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 714962012808 FAD binding site [chemical binding]; other site 714962012809 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 714962012810 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 714962012811 heme binding site [chemical binding]; other site 714962012812 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 714962012813 EamA-like transporter family; Region: EamA; pfam00892 714962012814 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714962012815 EamA-like transporter family; Region: EamA; pfam00892 714962012816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 714962012817 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 714962012818 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 714962012819 dimer interface [polypeptide binding]; other site 714962012820 active site 714962012821 metal binding site [ion binding]; metal-binding site 714962012822 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 714962012823 active site 714962012824 intersubunit interactions; other site 714962012825 catalytic residue [active] 714962012826 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 714962012827 dimerization domain swap beta strand [polypeptide binding]; other site 714962012828 regulatory protein interface [polypeptide binding]; other site 714962012829 active site 714962012830 regulatory phosphorylation site [posttranslational modification]; other site 714962012831 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 714962012832 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 714962012833 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 714962012834 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 714962012835 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 714962012836 active site 714962012837 phosphorylation site [posttranslational modification] 714962012838 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 714962012839 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 714962012840 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 714962012841 active site 714962012842 P-loop; other site 714962012843 phosphorylation site [posttranslational modification] 714962012844 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 714962012845 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 714962012846 dimer interface [polypeptide binding]; other site 714962012847 active site 714962012848 glycine loop; other site 714962012849 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 714962012850 FeS/SAM binding site; other site 714962012851 pyruvate formate lyase II activase; Provisional; Region: PRK10076 714962012852 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 714962012853 active site 714962012854 P-loop; other site 714962012855 phosphorylation site [posttranslational modification] 714962012856 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714962012857 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962012858 hypothetical protein; Provisional; Region: PRK10649 714962012859 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 714962012860 Sulfatase; Region: Sulfatase; pfam00884 714962012861 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 714962012862 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 714962012863 acetylornithine deacetylase; Provisional; Region: PRK05111 714962012864 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 714962012865 metal binding site [ion binding]; metal-binding site 714962012866 putative dimer interface [polypeptide binding]; other site 714962012867 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 714962012868 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 714962012869 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 714962012870 nucleotide binding site [chemical binding]; other site 714962012871 N-acetyl-L-glutamate binding site [chemical binding]; other site 714962012872 argininosuccinate lyase; Provisional; Region: PRK04833 714962012873 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 714962012874 active sites [active] 714962012875 tetramer interface [polypeptide binding]; other site 714962012876 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 714962012877 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 714962012878 putative active site pocket [active] 714962012879 putative metal binding site [ion binding]; other site 714962012880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962012881 D-galactonate transporter; Region: 2A0114; TIGR00893 714962012882 putative substrate translocation pore; other site 714962012883 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 714962012884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962012885 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 714962012886 dimerization interface [polypeptide binding]; other site 714962012887 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 714962012888 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714962012889 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 714962012890 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 714962012891 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 714962012892 metal binding site [ion binding]; metal-binding site 714962012893 putative dimer interface [polypeptide binding]; other site 714962012894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962012895 metabolite-proton symporter; Region: 2A0106; TIGR00883 714962012896 putative substrate translocation pore; other site 714962012897 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 714962012898 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714962012899 hypothetical protein; Provisional; Region: PRK11056 714962012900 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 714962012901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962012902 S-adenosylmethionine binding site [chemical binding]; other site 714962012903 glutamate racemase; Provisional; Region: PRK00865 714962012904 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 714962012905 FAD binding domain; Region: FAD_binding_4; pfam01565 714962012906 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 714962012907 Biotin operon repressor [Transcription]; Region: BirA; COG1654 714962012908 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 714962012909 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 714962012910 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 714962012911 pantothenate kinase; Provisional; Region: PRK05439 714962012912 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 714962012913 ATP-binding site [chemical binding]; other site 714962012914 CoA-binding site [chemical binding]; other site 714962012915 Mg2+-binding site [ion binding]; other site 714962012916 elongation factor Tu; Reviewed; Region: PRK00049 714962012917 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 714962012918 G1 box; other site 714962012919 GEF interaction site [polypeptide binding]; other site 714962012920 GTP/Mg2+ binding site [chemical binding]; other site 714962012921 Switch I region; other site 714962012922 G2 box; other site 714962012923 G3 box; other site 714962012924 Switch II region; other site 714962012925 G4 box; other site 714962012926 G5 box; other site 714962012927 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 714962012928 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 714962012929 Antibiotic Binding Site [chemical binding]; other site 714962012930 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 714962012931 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 714962012932 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 714962012933 putative homodimer interface [polypeptide binding]; other site 714962012934 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 714962012935 heterodimer interface [polypeptide binding]; other site 714962012936 homodimer interface [polypeptide binding]; other site 714962012937 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 714962012938 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 714962012939 23S rRNA interface [nucleotide binding]; other site 714962012940 L7/L12 interface [polypeptide binding]; other site 714962012941 putative thiostrepton binding site; other site 714962012942 L25 interface [polypeptide binding]; other site 714962012943 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 714962012944 mRNA/rRNA interface [nucleotide binding]; other site 714962012945 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 714962012946 23S rRNA interface [nucleotide binding]; other site 714962012947 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 714962012948 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 714962012949 core dimer interface [polypeptide binding]; other site 714962012950 peripheral dimer interface [polypeptide binding]; other site 714962012951 L10 interface [polypeptide binding]; other site 714962012952 L11 interface [polypeptide binding]; other site 714962012953 putative EF-Tu interaction site [polypeptide binding]; other site 714962012954 putative EF-G interaction site [polypeptide binding]; other site 714962012955 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 714962012956 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 714962012957 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 714962012958 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 714962012959 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 714962012960 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 714962012961 RPB3 interaction site [polypeptide binding]; other site 714962012962 RPB1 interaction site [polypeptide binding]; other site 714962012963 RPB11 interaction site [polypeptide binding]; other site 714962012964 RPB10 interaction site [polypeptide binding]; other site 714962012965 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 714962012966 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 714962012967 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 714962012968 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 714962012969 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 714962012970 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 714962012971 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 714962012972 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 714962012973 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 714962012974 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 714962012975 DNA binding site [nucleotide binding] 714962012976 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 714962012977 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 714962012978 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714962012979 FeS/SAM binding site; other site 714962012980 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 714962012981 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 714962012982 ThiS interaction site; other site 714962012983 putative active site [active] 714962012984 tetramer interface [polypeptide binding]; other site 714962012985 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 714962012986 thiS-thiF/thiG interaction site; other site 714962012987 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 714962012988 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 714962012989 ATP binding site [chemical binding]; other site 714962012990 substrate interface [chemical binding]; other site 714962012991 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 714962012992 thiamine phosphate binding site [chemical binding]; other site 714962012993 active site 714962012994 pyrophosphate binding site [ion binding]; other site 714962012995 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 714962012996 ThiC-associated domain; Region: ThiC-associated; pfam13667 714962012997 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 714962012998 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 714962012999 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 714962013000 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 714962013001 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 714962013002 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 714962013003 putative NADH binding site [chemical binding]; other site 714962013004 putative active site [active] 714962013005 nudix motif; other site 714962013006 putative metal binding site [ion binding]; other site 714962013007 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 714962013008 substrate binding site [chemical binding]; other site 714962013009 active site 714962013010 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 714962013011 Active_site [active] 714962013012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 714962013013 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 714962013014 IHF dimer interface [polypeptide binding]; other site 714962013015 IHF - DNA interface [nucleotide binding]; other site 714962013016 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 714962013017 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 714962013018 dimer interface [polypeptide binding]; other site 714962013019 sensor protein ZraS; Provisional; Region: PRK10364 714962013020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962013021 dimer interface [polypeptide binding]; other site 714962013022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962013023 ATP binding site [chemical binding]; other site 714962013024 Mg2+ binding site [ion binding]; other site 714962013025 G-X-G motif; other site 714962013026 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 714962013027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962013028 active site 714962013029 phosphorylation site [posttranslational modification] 714962013030 intermolecular recognition site; other site 714962013031 dimerization interface [polypeptide binding]; other site 714962013032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962013033 Walker A motif; other site 714962013034 ATP binding site [chemical binding]; other site 714962013035 Walker B motif; other site 714962013036 arginine finger; other site 714962013037 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 714962013038 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 714962013039 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 714962013040 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 714962013041 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 714962013042 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 714962013043 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 714962013044 purine monophosphate binding site [chemical binding]; other site 714962013045 dimer interface [polypeptide binding]; other site 714962013046 putative catalytic residues [active] 714962013047 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 714962013048 hypothetical protein; Provisional; Region: PRK10039 714962013049 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 714962013050 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714962013051 Coenzyme A binding pocket [chemical binding]; other site 714962013052 homoserine O-succinyltransferase; Provisional; Region: PRK05368 714962013053 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 714962013054 proposed active site lysine [active] 714962013055 conserved cys residue [active] 714962013056 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 714962013057 malate synthase A; Region: malate_syn_A; TIGR01344 714962013058 active site 714962013059 isocitrate lyase; Provisional; Region: PRK15063 714962013060 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 714962013061 tetramer interface [polypeptide binding]; other site 714962013062 active site 714962013063 Mg2+/Mn2+ binding site [ion binding]; other site 714962013064 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 714962013065 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 714962013066 transcriptional repressor IclR; Provisional; Region: PRK11569 714962013067 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 714962013068 Bacterial transcriptional regulator; Region: IclR; pfam01614 714962013069 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 714962013070 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 714962013071 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 714962013072 substrate binding pocket [chemical binding]; other site 714962013073 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 714962013074 B12 binding site [chemical binding]; other site 714962013075 cobalt ligand [ion binding]; other site 714962013076 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 714962013077 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 714962013078 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 714962013079 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 714962013080 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 714962013081 active site pocket [active] 714962013082 oxyanion hole [active] 714962013083 catalytic triad [active] 714962013084 active site nucleophile [active] 714962013085 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 714962013086 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 714962013087 putative NAD(P) binding site [chemical binding]; other site 714962013088 catalytic Zn binding site [ion binding]; other site 714962013089 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 714962013090 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 714962013091 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 714962013092 active site 714962013093 phosphorylation site [posttranslational modification] 714962013094 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 714962013095 active pocket/dimerization site; other site 714962013096 active site 714962013097 phosphorylation site [posttranslational modification] 714962013098 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 714962013099 classical (c) SDRs; Region: SDR_c; cd05233 714962013100 NAD(P) binding site [chemical binding]; other site 714962013101 active site 714962013102 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 714962013103 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714962013104 putative DNA binding site [nucleotide binding]; other site 714962013105 putative Zn2+ binding site [ion binding]; other site 714962013106 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 714962013107 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 714962013108 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714962013109 RNA binding surface [nucleotide binding]; other site 714962013110 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 714962013111 probable active site [active] 714962013112 hypothetical protein; Provisional; Region: PRK10515 714962013113 aspartate kinase III; Validated; Region: PRK09084 714962013114 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 714962013115 nucleotide binding site [chemical binding]; other site 714962013116 substrate binding site [chemical binding]; other site 714962013117 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 714962013118 lysine allosteric regulatory site; other site 714962013119 dimer interface [polypeptide binding]; other site 714962013120 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 714962013121 dimer interface [polypeptide binding]; other site 714962013122 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 714962013123 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 714962013124 active site 714962013125 dimer interface [polypeptide binding]; other site 714962013126 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 714962013127 dimer interface [polypeptide binding]; other site 714962013128 active site 714962013129 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 714962013130 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 714962013131 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 714962013132 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 714962013133 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 714962013134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962013135 dimer interface [polypeptide binding]; other site 714962013136 conserved gate region; other site 714962013137 putative PBP binding loops; other site 714962013138 ABC-ATPase subunit interface; other site 714962013139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962013140 dimer interface [polypeptide binding]; other site 714962013141 conserved gate region; other site 714962013142 putative PBP binding loops; other site 714962013143 ABC-ATPase subunit interface; other site 714962013144 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 714962013145 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 714962013146 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 714962013147 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 714962013148 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 714962013149 Walker A/P-loop; other site 714962013150 ATP binding site [chemical binding]; other site 714962013151 Q-loop/lid; other site 714962013152 ABC transporter signature motif; other site 714962013153 Walker B; other site 714962013154 D-loop; other site 714962013155 H-loop/switch region; other site 714962013156 TOBE domain; Region: TOBE_2; pfam08402 714962013157 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 714962013158 trimer interface; other site 714962013159 sugar binding site [chemical binding]; other site 714962013160 maltose regulon periplasmic protein; Provisional; Region: PRK10564 714962013161 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 714962013162 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 714962013163 UbiA prenyltransferase family; Region: UbiA; pfam01040 714962013164 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 714962013165 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 714962013166 putative acyl-acceptor binding pocket; other site 714962013167 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 714962013168 LexA repressor; Validated; Region: PRK00215 714962013169 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 714962013170 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 714962013171 Catalytic site [active] 714962013172 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 714962013173 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 714962013174 hypothetical protein; Provisional; Region: PRK10428 714962013175 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 714962013176 metal binding site 2 [ion binding]; metal-binding site 714962013177 putative DNA binding helix; other site 714962013178 metal binding site 1 [ion binding]; metal-binding site 714962013179 dimer interface [polypeptide binding]; other site 714962013180 structural Zn2+ binding site [ion binding]; other site 714962013181 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 714962013182 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 714962013183 FMN binding site [chemical binding]; other site 714962013184 active site 714962013185 catalytic residues [active] 714962013186 substrate binding site [chemical binding]; other site 714962013187 phage shock protein G; Reviewed; Region: pspG; PRK09459 714962013188 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 714962013189 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 714962013190 NADP binding site [chemical binding]; other site 714962013191 dimer interface [polypeptide binding]; other site 714962013192 L-aspartate oxidase; Provisional; Region: PRK06175 714962013193 FAD binding domain; Region: FAD_binding_2; pfam00890 714962013194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962013195 metabolite-proton symporter; Region: 2A0106; TIGR00883 714962013196 putative substrate translocation pore; other site 714962013197 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 714962013198 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 714962013199 substrate binding site [chemical binding]; other site 714962013200 oxyanion hole (OAH) forming residues; other site 714962013201 trimer interface [polypeptide binding]; other site 714962013202 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 714962013203 Coenzyme A transferase; Region: CoA_trans; smart00882 714962013204 Coenzyme A transferase; Region: CoA_trans; cl17247 714962013205 Transcriptional regulators [Transcription]; Region: PurR; COG1609 714962013206 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714962013207 DNA binding site [nucleotide binding] 714962013208 domain linker motif; other site 714962013209 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 714962013210 putative dimerization interface [polypeptide binding]; other site 714962013211 putative ligand binding site [chemical binding]; other site 714962013212 replicative DNA helicase; Provisional; Region: PRK08006 714962013213 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 714962013214 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 714962013215 Walker A motif; other site 714962013216 ATP binding site [chemical binding]; other site 714962013217 Walker B motif; other site 714962013218 DNA binding loops [nucleotide binding] 714962013219 alanine racemase; Reviewed; Region: alr; PRK00053 714962013220 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 714962013221 active site 714962013222 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 714962013223 substrate binding site [chemical binding]; other site 714962013224 catalytic residues [active] 714962013225 dimer interface [polypeptide binding]; other site 714962013226 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 714962013227 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 714962013228 active site 714962013229 nucleotide binding site [chemical binding]; other site 714962013230 HIGH motif; other site 714962013231 KMSKS motif; other site 714962013232 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 714962013233 AAA domain; Region: AAA_28; pfam13521 714962013234 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 714962013235 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714962013236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962013237 homodimer interface [polypeptide binding]; other site 714962013238 catalytic residue [active] 714962013239 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 714962013240 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 714962013241 TPP-binding site [chemical binding]; other site 714962013242 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 714962013243 dimer interface [polypeptide binding]; other site 714962013244 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 714962013245 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 714962013246 E3 interaction surface; other site 714962013247 lipoyl attachment site [posttranslational modification]; other site 714962013248 e3 binding domain; Region: E3_binding; pfam02817 714962013249 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 714962013250 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 714962013251 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 714962013252 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 714962013253 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 714962013254 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 714962013255 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 714962013256 CoA-ligase; Region: Ligase_CoA; pfam00549 714962013257 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 714962013258 CoA binding domain; Region: CoA_binding; smart00881 714962013259 CoA-ligase; Region: Ligase_CoA; pfam00549 714962013260 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 714962013261 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 714962013262 transmembrane helices; other site 714962013263 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 714962013264 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 714962013265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962013266 active site 714962013267 phosphorylation site [posttranslational modification] 714962013268 intermolecular recognition site; other site 714962013269 dimerization interface [polypeptide binding]; other site 714962013270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962013271 Walker A motif; other site 714962013272 ATP binding site [chemical binding]; other site 714962013273 Walker B motif; other site 714962013274 arginine finger; other site 714962013275 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 714962013276 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 714962013277 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962013278 dimer interface [polypeptide binding]; other site 714962013279 phosphorylation site [posttranslational modification] 714962013280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962013281 ATP binding site [chemical binding]; other site 714962013282 Mg2+ binding site [ion binding]; other site 714962013283 G-X-G motif; other site 714962013284 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962013285 active site 714962013286 motif I; other site 714962013287 motif II; other site 714962013288 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 714962013289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 714962013290 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 714962013291 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 714962013292 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 714962013293 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 714962013294 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 714962013295 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 714962013296 dimer interface [polypeptide binding]; other site 714962013297 ssDNA binding site [nucleotide binding]; other site 714962013298 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714962013299 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 714962013300 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 714962013301 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 714962013302 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714962013303 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 714962013304 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962013305 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 714962013306 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 714962013307 DNA binding residues [nucleotide binding] 714962013308 dimer interface [polypeptide binding]; other site 714962013309 [2Fe-2S] cluster binding site [ion binding]; other site 714962013310 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 714962013311 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 714962013312 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 714962013313 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714962013314 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 714962013315 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 714962013316 putative dimerization interface [polypeptide binding]; other site 714962013317 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 714962013318 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 714962013319 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 714962013320 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 714962013321 Na binding site [ion binding]; other site 714962013322 Predicted membrane protein [Function unknown]; Region: COG3162 714962013323 acetyl-CoA synthetase; Provisional; Region: PRK00174 714962013324 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 714962013325 active site 714962013326 CoA binding site [chemical binding]; other site 714962013327 acyl-activating enzyme (AAE) consensus motif; other site 714962013328 AMP binding site [chemical binding]; other site 714962013329 acetate binding site [chemical binding]; other site 714962013330 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 714962013331 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 714962013332 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 714962013333 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 714962013334 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 714962013335 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 714962013336 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 714962013337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714962013338 binding surface 714962013339 TPR motif; other site 714962013340 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 714962013341 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 714962013342 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 714962013343 Sel1-like repeats; Region: SEL1; smart00671 714962013344 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 714962013345 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714962013346 Walker A/P-loop; other site 714962013347 ATP binding site [chemical binding]; other site 714962013348 Q-loop/lid; other site 714962013349 ABC transporter signature motif; other site 714962013350 Walker B; other site 714962013351 D-loop; other site 714962013352 H-loop/switch region; other site 714962013353 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 714962013354 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714962013355 Walker A/P-loop; other site 714962013356 ATP binding site [chemical binding]; other site 714962013357 Q-loop/lid; other site 714962013358 ABC transporter signature motif; other site 714962013359 Walker B; other site 714962013360 D-loop; other site 714962013361 H-loop/switch region; other site 714962013362 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 714962013363 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 714962013364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962013365 dimer interface [polypeptide binding]; other site 714962013366 conserved gate region; other site 714962013367 ABC-ATPase subunit interface; other site 714962013368 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 714962013369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962013370 dimer interface [polypeptide binding]; other site 714962013371 conserved gate region; other site 714962013372 putative PBP binding loops; other site 714962013373 ABC-ATPase subunit interface; other site 714962013374 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 714962013375 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 714962013376 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 714962013377 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 714962013378 [4Fe-4S] binding site [ion binding]; other site 714962013379 molybdopterin cofactor binding site; other site 714962013380 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 714962013381 molybdopterin cofactor binding site; other site 714962013382 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 714962013383 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 714962013384 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 714962013385 multidrug resistance protein MdtN; Provisional; Region: PRK10476 714962013386 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 714962013387 HlyD family secretion protein; Region: HlyD_3; pfam13437 714962013388 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 714962013389 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 714962013390 D-allose kinase; Provisional; Region: PRK09698 714962013391 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 714962013392 nucleotide binding site [chemical binding]; other site 714962013393 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 714962013394 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 714962013395 substrate binding site [chemical binding]; other site 714962013396 hexamer interface [polypeptide binding]; other site 714962013397 metal binding site [ion binding]; metal-binding site 714962013398 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 714962013399 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962013400 Walker A/P-loop; other site 714962013401 ATP binding site [chemical binding]; other site 714962013402 Q-loop/lid; other site 714962013403 ABC transporter signature motif; other site 714962013404 Walker B; other site 714962013405 D-loop; other site 714962013406 H-loop/switch region; other site 714962013407 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 714962013408 D-allose transporter subunit; Provisional; Region: PRK09701 714962013409 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 714962013410 ligand binding site [chemical binding]; other site 714962013411 dimerization interface [polypeptide binding]; other site 714962013412 zinc binding site [ion binding]; other site 714962013413 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 714962013414 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 714962013415 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 714962013416 putative active site [active] 714962013417 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 714962013418 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 714962013419 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714962013420 Coenzyme A binding pocket [chemical binding]; other site 714962013421 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 714962013422 AAA domain; Region: AAA_18; pfam13238 714962013423 active site 714962013424 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 714962013425 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 714962013426 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 714962013427 active site 714962013428 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 714962013429 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 714962013430 Walker A/P-loop; other site 714962013431 ATP binding site [chemical binding]; other site 714962013432 Q-loop/lid; other site 714962013433 ABC transporter signature motif; other site 714962013434 Walker B; other site 714962013435 D-loop; other site 714962013436 H-loop/switch region; other site 714962013437 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 714962013438 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 714962013439 Walker A/P-loop; other site 714962013440 ATP binding site [chemical binding]; other site 714962013441 Q-loop/lid; other site 714962013442 ABC transporter signature motif; other site 714962013443 Walker B; other site 714962013444 D-loop; other site 714962013445 H-loop/switch region; other site 714962013446 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 714962013447 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 714962013448 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 714962013449 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 714962013450 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 714962013451 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 714962013452 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962013453 DNA-binding site [nucleotide binding]; DNA binding site 714962013454 UTRA domain; Region: UTRA; pfam07702 714962013455 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 714962013456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714962013457 dimer interface [polypeptide binding]; other site 714962013458 conserved gate region; other site 714962013459 putative PBP binding loops; other site 714962013460 ABC-ATPase subunit interface; other site 714962013461 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 714962013462 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714962013463 substrate binding pocket [chemical binding]; other site 714962013464 membrane-bound complex binding site; other site 714962013465 hinge residues; other site 714962013466 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 714962013467 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 714962013468 Walker A/P-loop; other site 714962013469 ATP binding site [chemical binding]; other site 714962013470 Q-loop/lid; other site 714962013471 ABC transporter signature motif; other site 714962013472 Walker B; other site 714962013473 D-loop; other site 714962013474 H-loop/switch region; other site 714962013475 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 714962013476 dimer interface [polypeptide binding]; other site 714962013477 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714962013478 hypothetical protein; Provisional; Region: PRK10220 714962013479 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 714962013480 PhnA protein; Region: PhnA; pfam03831 714962013481 hypothetical protein; Provisional; Region: PRK09866 714962013482 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 714962013483 G1 box; other site 714962013484 GTP/Mg2+ binding site [chemical binding]; other site 714962013485 G2 box; other site 714962013486 Switch I region; other site 714962013487 G3 box; other site 714962013488 Switch II region; other site 714962013489 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 714962013490 G2 box; other site 714962013491 Switch I region; other site 714962013492 G3 box; other site 714962013493 Switch II region; other site 714962013494 G4 box; other site 714962013495 G5 box; other site 714962013496 YjcZ-like protein; Region: YjcZ; pfam13990 714962013497 proline/glycine betaine transporter; Provisional; Region: PRK10642 714962013498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962013499 putative substrate translocation pore; other site 714962013500 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 714962013501 sensor protein BasS/PmrB; Provisional; Region: PRK10755 714962013502 HAMP domain; Region: HAMP; pfam00672 714962013503 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962013504 dimer interface [polypeptide binding]; other site 714962013505 phosphorylation site [posttranslational modification] 714962013506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962013507 ATP binding site [chemical binding]; other site 714962013508 Mg2+ binding site [ion binding]; other site 714962013509 G-X-G motif; other site 714962013510 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 714962013511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962013512 active site 714962013513 phosphorylation site [posttranslational modification] 714962013514 intermolecular recognition site; other site 714962013515 dimerization interface [polypeptide binding]; other site 714962013516 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714962013517 DNA binding site [nucleotide binding] 714962013518 putative metal dependent hydrolase; Provisional; Region: PRK11598 714962013519 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 714962013520 Sulfatase; Region: Sulfatase; pfam00884 714962013521 arginine:agmatin antiporter; Provisional; Region: PRK10644 714962013522 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714962013523 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962013524 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 714962013525 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962013526 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962013527 alpha-galactosidase; Provisional; Region: PRK15076 714962013528 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 714962013529 NAD binding site [chemical binding]; other site 714962013530 sugar binding site [chemical binding]; other site 714962013531 divalent metal binding site [ion binding]; other site 714962013532 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 714962013533 dimer interface [polypeptide binding]; other site 714962013534 hypothetical protein; Provisional; Region: PRK09867 714962013535 fumarate hydratase; Provisional; Region: PRK15389 714962013536 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 714962013537 Fumarase C-terminus; Region: Fumerase_C; pfam05683 714962013538 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 714962013539 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 714962013540 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 714962013541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962013542 active site 714962013543 phosphorylation site [posttranslational modification] 714962013544 intermolecular recognition site; other site 714962013545 dimerization interface [polypeptide binding]; other site 714962013546 Transcriptional regulator; Region: CitT; pfam12431 714962013547 sensory histidine kinase DcuS; Provisional; Region: PRK11086 714962013548 PAS domain; Region: PAS; smart00091 714962013549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962013550 ATP binding site [chemical binding]; other site 714962013551 Mg2+ binding site [ion binding]; other site 714962013552 G-X-G motif; other site 714962013553 Uncharacterized conserved protein [Function unknown]; Region: COG3592 714962013554 Predicted acetyltransferase [General function prediction only]; Region: COG2388 714962013555 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 714962013556 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 714962013557 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 714962013558 dimer interface [polypeptide binding]; other site 714962013559 putative anticodon binding site; other site 714962013560 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 714962013561 motif 1; other site 714962013562 active site 714962013563 motif 2; other site 714962013564 motif 3; other site 714962013565 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 714962013566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962013567 putative substrate translocation pore; other site 714962013568 POT family; Region: PTR2; pfam00854 714962013569 lysine decarboxylase CadA; Provisional; Region: PRK15400 714962013570 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 714962013571 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 714962013572 homodimer interface [polypeptide binding]; other site 714962013573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714962013574 catalytic residue [active] 714962013575 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 714962013576 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 714962013577 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 714962013578 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714962013579 DNA binding site [nucleotide binding] 714962013580 putative transcriptional regulator; Provisional; Region: PRK11640 714962013581 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714962013582 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 714962013583 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 714962013584 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 714962013585 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 714962013586 DsbD alpha interface [polypeptide binding]; other site 714962013587 catalytic residues [active] 714962013588 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 714962013589 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 714962013590 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 714962013591 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 714962013592 Aspartase; Region: Aspartase; cd01357 714962013593 active sites [active] 714962013594 tetramer interface [polypeptide binding]; other site 714962013595 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 714962013596 putative transporter; Provisional; Region: PRK11021 714962013597 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 714962013598 oligomerisation interface [polypeptide binding]; other site 714962013599 mobile loop; other site 714962013600 roof hairpin; other site 714962013601 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 714962013602 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 714962013603 ring oligomerisation interface [polypeptide binding]; other site 714962013604 ATP/Mg binding site [chemical binding]; other site 714962013605 stacking interactions; other site 714962013606 hinge regions; other site 714962013607 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 714962013608 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 714962013609 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714962013610 FeS/SAM binding site; other site 714962013611 elongation factor P; Validated; Region: PRK00529 714962013612 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 714962013613 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 714962013614 RNA binding site [nucleotide binding]; other site 714962013615 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 714962013616 RNA binding site [nucleotide binding]; other site 714962013617 entericidin A; Provisional; Region: PRK09810 714962013618 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 714962013619 multidrug efflux system protein; Provisional; Region: PRK11431 714962013620 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 714962013621 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 714962013622 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 714962013623 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714962013624 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 714962013625 Iron-sulfur protein interface; other site 714962013626 proximal quinone binding site [chemical binding]; other site 714962013627 C-subunit interface; other site 714962013628 distal quinone binding site; other site 714962013629 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 714962013630 D-subunit interface [polypeptide binding]; other site 714962013631 Iron-sulfur protein interface; other site 714962013632 proximal quinone binding site [chemical binding]; other site 714962013633 distal quinone binding site [chemical binding]; other site 714962013634 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 714962013635 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 714962013636 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 714962013637 L-aspartate oxidase; Provisional; Region: PRK06175 714962013638 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 714962013639 poxB regulator PoxA; Provisional; Region: PRK09350 714962013640 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 714962013641 motif 1; other site 714962013642 dimer interface [polypeptide binding]; other site 714962013643 active site 714962013644 motif 2; other site 714962013645 motif 3; other site 714962013646 inner membrane transporter YjeM; Provisional; Region: PRK15238 714962013647 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 714962013648 putative mechanosensitive channel protein; Provisional; Region: PRK10929 714962013649 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 714962013650 DNA-binding site [nucleotide binding]; DNA binding site 714962013651 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 714962013652 Mechanosensitive ion channel; Region: MS_channel; pfam00924 714962013653 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 714962013654 GTPase RsgA; Reviewed; Region: PRK12288 714962013655 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 714962013656 RNA binding site [nucleotide binding]; other site 714962013657 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 714962013658 GTPase/Zn-binding domain interface [polypeptide binding]; other site 714962013659 GTP/Mg2+ binding site [chemical binding]; other site 714962013660 G4 box; other site 714962013661 G5 box; other site 714962013662 G1 box; other site 714962013663 Switch I region; other site 714962013664 G2 box; other site 714962013665 G3 box; other site 714962013666 Switch II region; other site 714962013667 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 714962013668 catalytic site [active] 714962013669 putative active site [active] 714962013670 putative substrate binding site [chemical binding]; other site 714962013671 dimer interface [polypeptide binding]; other site 714962013672 putative carbohydrate kinase; Provisional; Region: PRK10565 714962013673 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 714962013674 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 714962013675 putative substrate binding site [chemical binding]; other site 714962013676 putative ATP binding site [chemical binding]; other site 714962013677 ADP-binding protein; Provisional; Region: PRK10646 714962013678 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 714962013679 AMIN domain; Region: AMIN; pfam11741 714962013680 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 714962013681 active site 714962013682 metal binding site [ion binding]; metal-binding site 714962013683 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 714962013684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962013685 ATP binding site [chemical binding]; other site 714962013686 Mg2+ binding site [ion binding]; other site 714962013687 G-X-G motif; other site 714962013688 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 714962013689 ATP binding site [chemical binding]; other site 714962013690 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 714962013691 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 714962013692 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 714962013693 bacterial Hfq-like; Region: Hfq; cd01716 714962013694 hexamer interface [polypeptide binding]; other site 714962013695 Sm1 motif; other site 714962013696 RNA binding site [nucleotide binding]; other site 714962013697 Sm2 motif; other site 714962013698 GTPase HflX; Provisional; Region: PRK11058 714962013699 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 714962013700 HflX GTPase family; Region: HflX; cd01878 714962013701 G1 box; other site 714962013702 GTP/Mg2+ binding site [chemical binding]; other site 714962013703 Switch I region; other site 714962013704 G2 box; other site 714962013705 G3 box; other site 714962013706 Switch II region; other site 714962013707 G4 box; other site 714962013708 G5 box; other site 714962013709 FtsH protease regulator HflK; Provisional; Region: PRK10930 714962013710 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 714962013711 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 714962013712 FtsH protease regulator HflC; Provisional; Region: PRK11029 714962013713 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 714962013714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 714962013715 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 714962013716 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 714962013717 GDP-binding site [chemical binding]; other site 714962013718 ACT binding site; other site 714962013719 IMP binding site; other site 714962013720 Predicted transcriptional regulator [Transcription]; Region: COG1959 714962013721 transcriptional repressor NsrR; Provisional; Region: PRK11014 714962013722 exoribonuclease R; Provisional; Region: PRK11642 714962013723 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 714962013724 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 714962013725 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 714962013726 RNB domain; Region: RNB; pfam00773 714962013727 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 714962013728 RNA binding site [nucleotide binding]; other site 714962013729 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 714962013730 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 714962013731 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 714962013732 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 714962013733 PspA/IM30 family; Region: PspA_IM30; pfam04012 714962013734 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 714962013735 Predicted membrane protein [Function unknown]; Region: COG3766 714962013736 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 714962013737 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 714962013738 Predicted integral membrane protein [Function unknown]; Region: COG5463 714962013739 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 714962013740 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 714962013741 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 714962013742 FAD binding site [chemical binding]; other site 714962013743 substrate binding site [chemical binding]; other site 714962013744 catalytic residues [active] 714962013745 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 714962013746 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 714962013747 esterase; Provisional; Region: PRK10566 714962013748 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 714962013749 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 714962013750 transcriptional repressor UlaR; Provisional; Region: PRK13509 714962013751 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 714962013752 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 714962013753 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 714962013754 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 714962013755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 714962013756 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 714962013757 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 714962013758 active site 714962013759 P-loop; other site 714962013760 phosphorylation site [posttranslational modification] 714962013761 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 714962013762 active site 714962013763 phosphorylation site [posttranslational modification] 714962013764 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 714962013765 active site 714962013766 dimer interface [polypeptide binding]; other site 714962013767 magnesium binding site [ion binding]; other site 714962013768 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 714962013769 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 714962013770 AP (apurinic/apyrimidinic) site pocket; other site 714962013771 DNA interaction; other site 714962013772 Metal-binding active site; metal-binding site 714962013773 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 714962013774 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 714962013775 intersubunit interface [polypeptide binding]; other site 714962013776 active site 714962013777 Zn2+ binding site [ion binding]; other site 714962013778 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 714962013779 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 714962013780 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 714962013781 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 714962013782 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 714962013783 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 714962013784 Helix-turn-helix domain; Region: HTH_31; pfam13560 714962013785 sequence-specific DNA binding site [nucleotide binding]; other site 714962013786 salt bridge; other site 714962013787 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 714962013788 HipA-like N-terminal domain; Region: HipA_N; pfam07805 714962013789 HipA-like C-terminal domain; Region: HipA_C; pfam07804 714962013790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962013791 D-galactonate transporter; Region: 2A0114; TIGR00893 714962013792 putative substrate translocation pore; other site 714962013793 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 714962013794 L-aspartate oxidase; Provisional; Region: PRK06175 714962013795 L-aspartate oxidase; Provisional; Region: PRK06175 714962013796 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 714962013797 Coenzyme A transferase; Region: CoA_trans; smart00882 714962013798 Coenzyme A transferase; Region: CoA_trans; cl17247 714962013799 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 714962013800 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 714962013801 substrate binding site [chemical binding]; other site 714962013802 oxyanion hole (OAH) forming residues; other site 714962013803 trimer interface [polypeptide binding]; other site 714962013804 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 714962013805 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 714962013806 putative NAD(P) binding site [chemical binding]; other site 714962013807 active site 714962013808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714962013809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 714962013810 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 714962013811 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 714962013812 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 714962013813 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 714962013814 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 714962013815 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 714962013816 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 714962013817 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 714962013818 Hemerythrin-like domain; Region: Hr-like; cd12108 714962013819 Fe binding site [ion binding]; other site 714962013820 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 714962013821 EamA-like transporter family; Region: EamA; pfam00892 714962013822 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 714962013823 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 714962013824 NADP binding site [chemical binding]; other site 714962013825 Predicted transcriptional regulators [Transcription]; Region: COG1733 714962013826 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 714962013827 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 714962013828 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 714962013829 active site 714962013830 metal binding site [ion binding]; metal-binding site 714962013831 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 714962013832 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 714962013833 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 714962013834 active site 714962013835 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 714962013836 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 714962013837 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 714962013838 Domain of unknown function DUF21; Region: DUF21; pfam01595 714962013839 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 714962013840 Transporter associated domain; Region: CorC_HlyC; smart01091 714962013841 methionine sulfoxide reductase A; Provisional; Region: PRK00058 714962013842 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 714962013843 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 714962013844 Surface antigen; Region: Bac_surface_Ag; pfam01103 714962013845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 714962013846 Family of unknown function (DUF490); Region: DUF490; pfam04357 714962013847 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 714962013848 putative active site pocket [active] 714962013849 dimerization interface [polypeptide binding]; other site 714962013850 putative catalytic residue [active] 714962013851 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 714962013852 dimer interface [polypeptide binding]; other site 714962013853 substrate binding site [chemical binding]; other site 714962013854 metal binding sites [ion binding]; metal-binding site 714962013855 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 714962013856 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 714962013857 putative ligand binding site [chemical binding]; other site 714962013858 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 714962013859 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 714962013860 Walker A/P-loop; other site 714962013861 ATP binding site [chemical binding]; other site 714962013862 Q-loop/lid; other site 714962013863 ABC transporter signature motif; other site 714962013864 Walker B; other site 714962013865 D-loop; other site 714962013866 H-loop/switch region; other site 714962013867 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 714962013868 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 714962013869 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 714962013870 TM-ABC transporter signature motif; other site 714962013871 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 714962013872 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 714962013873 TM-ABC transporter signature motif; other site 714962013874 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 714962013875 AMP binding site [chemical binding]; other site 714962013876 metal binding site [ion binding]; metal-binding site 714962013877 active site 714962013878 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 714962013879 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 714962013880 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714962013881 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714962013882 hypothetical protein; Provisional; Region: PRK05255 714962013883 peptidase PmbA; Provisional; Region: PRK11040 714962013884 cytochrome b562; Provisional; Region: PRK15058 714962013885 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 714962013886 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714962013887 FeS/SAM binding site; other site 714962013888 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 714962013889 ATP cone domain; Region: ATP-cone; pfam03477 714962013890 Class III ribonucleotide reductase; Region: RNR_III; cd01675 714962013891 effector binding site; other site 714962013892 active site 714962013893 Zn binding site [ion binding]; other site 714962013894 glycine loop; other site 714962013895 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 714962013896 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 714962013897 Ca binding site [ion binding]; other site 714962013898 active site 714962013899 catalytic site [active] 714962013900 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 714962013901 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 714962013902 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714962013903 active site turn [active] 714962013904 phosphorylation site [posttranslational modification] 714962013905 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 714962013906 trehalose repressor; Provisional; Region: treR; PRK09492 714962013907 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714962013908 DNA binding site [nucleotide binding] 714962013909 domain linker motif; other site 714962013910 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 714962013911 dimerization interface [polypeptide binding]; other site 714962013912 ligand binding site [chemical binding]; other site 714962013913 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 714962013914 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 714962013915 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714962013916 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 714962013917 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962013918 motif II; other site 714962013919 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 714962013920 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 714962013921 homotrimer interaction site [polypeptide binding]; other site 714962013922 putative active site [active] 714962013923 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 714962013924 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 714962013925 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 714962013926 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 714962013927 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 714962013928 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 714962013929 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 714962013930 Arginine repressor [Transcription]; Region: ArgR; COG1438 714962013931 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 714962013932 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 714962013933 Predicted membrane protein [Function unknown]; Region: COG1288 714962013934 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 714962013935 ornithine carbamoyltransferase; Validated; Region: PRK02102 714962013936 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 714962013937 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 714962013938 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 714962013939 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 714962013940 putative substrate binding site [chemical binding]; other site 714962013941 nucleotide binding site [chemical binding]; other site 714962013942 nucleotide binding site [chemical binding]; other site 714962013943 homodimer interface [polypeptide binding]; other site 714962013944 arginine deiminase; Provisional; Region: PRK01388 714962013945 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 714962013946 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 714962013947 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 714962013948 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 714962013949 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 714962013950 RNase E inhibitor protein; Provisional; Region: PRK11191 714962013951 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714962013952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714962013953 Coenzyme A binding pocket [chemical binding]; other site 714962013954 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 714962013955 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 714962013956 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 714962013957 HIGH motif; other site 714962013958 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 714962013959 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 714962013960 active site 714962013961 KMSKS motif; other site 714962013962 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 714962013963 tRNA binding surface [nucleotide binding]; other site 714962013964 anticodon binding site; other site 714962013965 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 714962013966 DNA polymerase III subunit chi; Validated; Region: PRK05728 714962013967 multifunctional aminopeptidase A; Provisional; Region: PRK00913 714962013968 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 714962013969 interface (dimer of trimers) [polypeptide binding]; other site 714962013970 Substrate-binding/catalytic site; other site 714962013971 Zn-binding sites [ion binding]; other site 714962013972 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 714962013973 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 714962013974 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 714962013975 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 714962013976 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 714962013977 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 714962013978 Walker A motif; other site 714962013979 ATP binding site [chemical binding]; other site 714962013980 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 714962013981 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714962013982 DNA binding site [nucleotide binding] 714962013983 domain linker motif; other site 714962013984 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 714962013985 putative dimerization interface [polypeptide binding]; other site 714962013986 putative ligand binding site [chemical binding]; other site 714962013987 fructuronate transporter; Provisional; Region: PRK10034; cl15264 714962013988 gluconate transporter; Region: gntP; TIGR00791 714962013989 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 714962013990 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 714962013991 NADP binding site [chemical binding]; other site 714962013992 homodimer interface [polypeptide binding]; other site 714962013993 active site 714962013994 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 714962013995 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 714962013996 putative NAD(P) binding site [chemical binding]; other site 714962013997 catalytic Zn binding site [ion binding]; other site 714962013998 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 714962013999 ATP-binding site [chemical binding]; other site 714962014000 Gluconate-6-phosphate binding site [chemical binding]; other site 714962014001 Shikimate kinase; Region: SKI; pfam01202 714962014002 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 714962014003 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 714962014004 putative NAD(P) binding site [chemical binding]; other site 714962014005 putative substrate binding site [chemical binding]; other site 714962014006 catalytic Zn binding site [ion binding]; other site 714962014007 structural Zn binding site [ion binding]; other site 714962014008 dimer interface [polypeptide binding]; other site 714962014009 integrase; Provisional; Region: PRK09692 714962014010 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 714962014011 active site 714962014012 Int/Topo IB signature motif; other site 714962014013 Beta protein; Region: Beta_protein; pfam14350 714962014014 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 714962014015 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 714962014016 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 714962014017 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 714962014018 Ash protein family; Region: Phage_ASH; pfam10554 714962014019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 714962014020 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 714962014021 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 714962014022 active site 714962014023 metal binding site [ion binding]; metal-binding site 714962014024 interdomain interaction site; other site 714962014025 D5 N terminal like; Region: D5_N; smart00885 714962014026 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 714962014027 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 714962014028 Predicted ATP-dependent Lon-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG4930 714962014029 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 714962014030 HNH endonuclease; Region: HNH_2; pfam13391 714962014031 Domain of unknown function (DUF303); Region: DUF303; pfam03629 714962014032 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 714962014033 Kelch motif; Region: Kelch_1; pfam01344 714962014034 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 714962014035 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 714962014036 Int/Topo IB signature motif; other site 714962014037 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 714962014038 Int/Topo IB signature motif; other site 714962014039 Fimbrial protein; Region: Fimbrial; cl01416 714962014040 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 714962014041 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 714962014042 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 714962014043 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 714962014044 outer membrane usher protein; Provisional; Region: PRK15193 714962014045 PapC N-terminal domain; Region: PapC_N; pfam13954 714962014046 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 714962014047 PapC C-terminal domain; Region: PapC_C; pfam13953 714962014048 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 714962014049 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 714962014050 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 714962014051 mannosyl binding site [chemical binding]; other site 714962014052 Fimbrial protein; Region: Fimbrial; pfam00419 714962014053 fructuronate transporter; Provisional; Region: PRK10034; cl15264 714962014054 mannonate dehydratase; Region: uxuA; TIGR00695 714962014055 mannonate dehydratase; Provisional; Region: PRK03906 714962014056 D-mannonate oxidoreductase; Provisional; Region: PRK15037 714962014057 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 714962014058 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 714962014059 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 714962014060 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962014061 DNA-binding site [nucleotide binding]; DNA binding site 714962014062 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 714962014063 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 714962014064 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 714962014065 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 714962014066 active site 714962014067 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 714962014068 dimerization domain swap beta strand [polypeptide binding]; other site 714962014069 regulatory protein interface [polypeptide binding]; other site 714962014070 active site 714962014071 regulatory phosphorylation site [posttranslational modification]; other site 714962014072 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 714962014073 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 714962014074 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 714962014075 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 714962014076 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 714962014077 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 714962014078 Dak1 domain; Region: Dak1; pfam02733 714962014079 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 714962014080 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 714962014081 dimer interface [polypeptide binding]; other site 714962014082 active site 714962014083 metal binding site [ion binding]; metal-binding site 714962014084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714962014085 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714962014086 putative substrate translocation pore; other site 714962014087 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 714962014088 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 714962014089 BCCT family transporter; Region: BCCT; pfam02028 714962014090 glycerate kinase; Region: TIGR00045 714962014091 tartronate semialdehyde reductase; Provisional; Region: PRK15059 714962014092 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 714962014093 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 714962014094 GAF domain; Region: GAF; pfam01590 714962014095 PAS domain; Region: PAS; smart00091 714962014096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962014097 Walker A motif; other site 714962014098 ATP binding site [chemical binding]; other site 714962014099 Walker B motif; other site 714962014100 arginine finger; other site 714962014101 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 714962014102 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 714962014103 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 714962014104 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 714962014105 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 714962014106 dimer interface [polypeptide binding]; other site 714962014107 active site 714962014108 hypothetical protein; Provisional; Region: PRK10519 714962014109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 714962014110 Nucleoside recognition; Region: Gate; pfam07670 714962014111 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 714962014112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 714962014113 SdiA-regulated; Region: SdiA-regulated; cd09971 714962014114 putative active site [active] 714962014115 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 714962014116 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 714962014117 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 714962014118 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 714962014119 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 714962014120 Predicted membrane protein [Function unknown]; Region: COG2733 714962014121 putative transposase; Provisional; Region: PRK09857 714962014122 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 714962014123 Uncharacterized conserved protein [Function unknown]; Region: COG1479 714962014124 Protein of unknown function DUF262; Region: DUF262; pfam03235 714962014125 Protein of unknown function DUF262; Region: DUF262; pfam03235 714962014126 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 714962014127 Uncharacterized conserved protein [Function unknown]; Region: COG3586 714962014128 endoribonuclease SymE; Provisional; Region: PRK13605 714962014129 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 714962014130 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 714962014131 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 714962014132 HsdM N-terminal domain; Region: HsdM_N; pfam12161 714962014133 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 714962014134 Methyltransferase domain; Region: Methyltransf_26; pfam13659 714962014135 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 714962014136 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 714962014137 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 714962014138 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714962014139 ATP binding site [chemical binding]; other site 714962014140 putative Mg++ binding site [ion binding]; other site 714962014141 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 714962014142 Mrr N-terminal domain; Region: Mrr_N; pfam14338 714962014143 Restriction endonuclease; Region: Mrr_cat; pfam04471 714962014144 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 714962014145 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 714962014146 P-loop, Walker A motif; other site 714962014147 Base recognition motif; other site 714962014148 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 714962014149 Uncharacterized small protein [Function unknown]; Region: COG2879 714962014150 carbon starvation protein A; Provisional; Region: PRK15015 714962014151 Carbon starvation protein CstA; Region: CstA; pfam02554 714962014152 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 714962014153 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 714962014154 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 714962014155 dimer interface [polypeptide binding]; other site 714962014156 ligand binding site [chemical binding]; other site 714962014157 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714962014158 dimerization interface [polypeptide binding]; other site 714962014159 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 714962014160 dimer interface [polypeptide binding]; other site 714962014161 putative CheW interface [polypeptide binding]; other site 714962014162 DctM-like transporters; Region: DctM; pfam06808 714962014163 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 714962014164 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 714962014165 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 714962014166 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 714962014167 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 714962014168 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 714962014169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714962014170 DNA-binding site [nucleotide binding]; DNA binding site 714962014171 Transcriptional regulators [Transcription]; Region: GntR; COG1802 714962014172 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 714962014173 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 714962014174 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 714962014175 putative NAD(P) binding site [chemical binding]; other site 714962014176 catalytic Zn binding site [ion binding]; other site 714962014177 structural Zn binding site [ion binding]; other site 714962014178 phosphoglycerol transferase I; Provisional; Region: PRK03776 714962014179 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 714962014180 hypothetical protein; Provisional; Region: PRK11667 714962014181 DNA replication protein DnaC; Validated; Region: PRK07952 714962014182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714962014183 Walker A motif; other site 714962014184 ATP binding site [chemical binding]; other site 714962014185 Walker B motif; other site 714962014186 primosomal protein DnaI; Provisional; Region: PRK02854 714962014187 hypothetical protein; Provisional; Region: PRK09917 714962014188 Uncharacterized conserved protein [Function unknown]; Region: COG2966 714962014189 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 714962014190 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714962014191 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714962014192 DNA binding residues [nucleotide binding] 714962014193 dimerization interface [polypeptide binding]; other site 714962014194 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 714962014195 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714962014196 DNA binding residues [nucleotide binding] 714962014197 dimerization interface [polypeptide binding]; other site 714962014198 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 714962014199 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 714962014200 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 714962014201 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 714962014202 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 714962014203 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 714962014204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714962014205 S-adenosylmethionine binding site [chemical binding]; other site 714962014206 DNA polymerase III subunit psi; Validated; Region: PRK06856 714962014207 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 714962014208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714962014209 Coenzyme A binding pocket [chemical binding]; other site 714962014210 dUMP phosphatase; Provisional; Region: PRK09449 714962014211 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962014212 motif II; other site 714962014213 integrase; Provisional; Region: PRK09692 714962014214 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 714962014215 active site 714962014216 Int/Topo IB signature motif; other site 714962014217 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 714962014218 Active Sites [active] 714962014219 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 714962014220 Uncharacterized conserved protein [Function unknown]; Region: COG5532 714962014221 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 714962014222 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 714962014223 Catalytic site [active] 714962014224 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 714962014225 Ash protein family; Region: Phage_ASH; pfam10554 714962014226 Helix-turn-helix domain; Region: HTH_36; pfam13730 714962014227 PerC transcriptional activator; Region: PerC; pfam06069 714962014228 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 714962014229 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 714962014230 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 714962014231 KilA-N domain; Region: KilA-N; pfam04383 714962014232 Protein of unknown function (DUF968); Region: DUF968; pfam06147 714962014233 Antitermination protein; Region: Antiterm; pfam03589 714962014234 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 714962014235 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 714962014236 Zn binding sites [ion binding]; other site 714962014237 Antitermination protein; Region: Antiterm; pfam03589 714962014238 Lysis protein S; Region: Lysis_S; pfam04971 714962014239 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 714962014240 catalytic residues [active] 714962014241 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 714962014242 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cl00097 714962014243 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 714962014244 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 714962014245 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 714962014246 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 714962014247 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 714962014248 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 714962014249 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 714962014250 oligomer interface [polypeptide binding]; other site 714962014251 active site residues [active] 714962014252 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 714962014253 Uncharacterized conserved protein [Function unknown]; Region: COG5471 714962014254 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 714962014255 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 714962014256 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 714962014257 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 714962014258 Bacterial Ig-like domain 2; Region: BID_2; smart00635 714962014259 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 714962014260 Minor tail protein T; Region: Phage_tail_T; pfam06223 714962014261 Phage-related minor tail protein [Function unknown]; Region: COG5281 714962014262 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 714962014263 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 714962014264 Phage-related protein [Function unknown]; Region: COG4718 714962014265 Phage-related protein [Function unknown]; Region: gp18; COG4672 714962014266 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 714962014267 MPN+ (JAMM) motif; other site 714962014268 Zinc-binding site [ion binding]; other site 714962014269 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 714962014270 NlpC/P60 family; Region: NLPC_P60; cl17555 714962014271 Phage-related protein, tail component [Function unknown]; Region: COG4723 714962014272 Phage-related protein, tail component [Function unknown]; Region: COG4733 714962014273 Putative phage tail protein; Region: Phage-tail_3; pfam13550 714962014274 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 714962014275 Fibronectin type III protein; Region: DUF3672; pfam12421 714962014276 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 714962014277 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 714962014278 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 714962014279 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 714962014280 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 714962014281 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 714962014282 active site 714962014283 NTP binding site [chemical binding]; other site 714962014284 nucleic acid binding site [nucleotide binding]; other site 714962014285 DinI-like family; Region: DinI; pfam06183 714962014286 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 714962014287 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 714962014288 G1 box; other site 714962014289 putative GEF interaction site [polypeptide binding]; other site 714962014290 GTP/Mg2+ binding site [chemical binding]; other site 714962014291 Switch I region; other site 714962014292 G2 box; other site 714962014293 G3 box; other site 714962014294 Switch II region; other site 714962014295 G4 box; other site 714962014296 G5 box; other site 714962014297 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 714962014298 periplasmic protein; Provisional; Region: PRK10568 714962014299 BON domain; Region: BON; pfam04972 714962014300 BON domain; Region: BON; pfam04972 714962014301 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 714962014302 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 714962014303 active site 714962014304 nucleophile elbow; other site 714962014305 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 714962014306 active site 714962014307 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 714962014308 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714962014309 FeS/SAM binding site; other site 714962014310 hypothetical protein; Provisional; Region: PRK10977 714962014311 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 714962014312 intersubunit interface [polypeptide binding]; other site 714962014313 active site 714962014314 catalytic residue [active] 714962014315 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 714962014316 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 714962014317 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 714962014318 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 714962014319 phosphopentomutase; Provisional; Region: PRK05362 714962014320 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 714962014321 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 714962014322 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 714962014323 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 714962014324 HipA-like N-terminal domain; Region: HipA_N; pfam07805 714962014325 HipA-like C-terminal domain; Region: HipA_C; pfam07804 714962014326 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 714962014327 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 714962014328 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 714962014329 hypothetical protein; Provisional; Region: PRK11246 714962014330 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 714962014331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714962014332 motif II; other site 714962014333 DNA repair protein RadA; Region: sms; TIGR00416 714962014334 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 714962014335 Walker A motif/ATP binding site; other site 714962014336 ATP binding site [chemical binding]; other site 714962014337 Walker B motif; other site 714962014338 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 714962014339 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714962014340 non-specific DNA binding site [nucleotide binding]; other site 714962014341 salt bridge; other site 714962014342 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 714962014343 sequence-specific DNA binding site [nucleotide binding]; other site 714962014344 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 714962014345 active site 714962014346 (T/H)XGH motif; other site 714962014347 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 714962014348 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 714962014349 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714962014350 non-specific DNA binding site [nucleotide binding]; other site 714962014351 salt bridge; other site 714962014352 sequence-specific DNA binding site [nucleotide binding]; other site 714962014353 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 714962014354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 714962014355 Walker A/P-loop; other site 714962014356 ATP binding site [chemical binding]; other site 714962014357 Q-loop/lid; other site 714962014358 ABC transporter signature motif; other site 714962014359 Walker B; other site 714962014360 D-loop; other site 714962014361 H-loop/switch region; other site 714962014362 ABC transporter; Region: ABC_tran_2; pfam12848 714962014363 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 714962014364 lytic murein transglycosylase; Provisional; Region: PRK11619 714962014365 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 714962014366 N-acetyl-D-glucosamine binding site [chemical binding]; other site 714962014367 catalytic residue [active] 714962014368 Trp operon repressor; Provisional; Region: PRK01381 714962014369 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 714962014370 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714962014371 catalytic core [active] 714962014372 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 714962014373 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714962014374 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 714962014375 hypothetical protein; Provisional; Region: PRK10756 714962014376 CreA protein; Region: CreA; pfam05981 714962014377 DNA-binding response regulator CreB; Provisional; Region: PRK11083 714962014378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962014379 active site 714962014380 phosphorylation site [posttranslational modification] 714962014381 intermolecular recognition site; other site 714962014382 dimerization interface [polypeptide binding]; other site 714962014383 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714962014384 DNA binding site [nucleotide binding] 714962014385 sensory histidine kinase CreC; Provisional; Region: PRK11100 714962014386 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714962014387 dimerization interface [polypeptide binding]; other site 714962014388 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714962014389 dimer interface [polypeptide binding]; other site 714962014390 phosphorylation site [posttranslational modification] 714962014391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714962014392 ATP binding site [chemical binding]; other site 714962014393 Mg2+ binding site [ion binding]; other site 714962014394 G-X-G motif; other site 714962014395 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 714962014396 two-component response regulator; Provisional; Region: PRK11173 714962014397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714962014398 active site 714962014399 phosphorylation site [posttranslational modification] 714962014400 intermolecular recognition site; other site 714962014401 dimerization interface [polypeptide binding]; other site 714962014402 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714962014403 DNA binding site [nucleotide binding] 714962014404 putative RNA methyltransferase; Provisional; Region: PRK10433 714962014405 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050