-- dump date   	20140619_083031
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
595495000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
595495000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
595495000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495000004	Walker A motif; other site
595495000005	ATP binding site [chemical binding]; other site
595495000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
595495000007	Walker B motif; other site
595495000008	arginine finger; other site
595495000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
595495000010	DnaA box-binding interface [nucleotide binding]; other site
595495000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
595495000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
595495000013	putative DNA binding surface [nucleotide binding]; other site
595495000014	dimer interface [polypeptide binding]; other site
595495000015	beta-clamp/clamp loader binding surface; other site
595495000016	beta-clamp/translesion DNA polymerase binding surface; other site
595495000017	recF protein; Region: recf; TIGR00611
595495000018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495000019	Walker A/P-loop; other site
595495000020	ATP binding site [chemical binding]; other site
595495000021	Q-loop/lid; other site
595495000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495000023	ABC transporter signature motif; other site
595495000024	Walker B; other site
595495000025	D-loop; other site
595495000026	H-loop/switch region; other site
595495000027	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
595495000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495000029	Mg2+ binding site [ion binding]; other site
595495000030	G-X-G motif; other site
595495000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
595495000032	anchoring element; other site
595495000033	dimer interface [polypeptide binding]; other site
595495000034	ATP binding site [chemical binding]; other site
595495000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
595495000036	active site
595495000037	putative metal-binding site [ion binding]; other site
595495000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
595495000039	hypothetical protein; Provisional; Region: PRK11426
595495000040	sugar phosphate phosphatase; Provisional; Region: PRK10513
595495000041	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495000042	active site
595495000043	motif I; other site
595495000044	motif II; other site
595495000045	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495000046	hypothetical protein; Provisional; Region: PRK10215
595495000047	Transcriptional regulators [Transcription]; Region: FadR; COG2186
595495000048	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495000049	DNA-binding site [nucleotide binding]; DNA binding site
595495000050	FCD domain; Region: FCD; pfam07729
595495000051	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
595495000052	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
595495000053	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
595495000054	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
595495000055	active site
595495000056	intersubunit interface [polypeptide binding]; other site
595495000057	catalytic residue [active]
595495000058	galactonate dehydratase; Provisional; Region: PRK14017
595495000059	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
595495000060	putative active site pocket [active]
595495000061	putative metal binding site [ion binding]; other site
595495000062	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495000063	D-galactonate transporter; Region: 2A0114; TIGR00893
595495000064	putative substrate translocation pore; other site
595495000065	putative oxidoreductase; Provisional; Region: PRK11445
595495000066	hypothetical protein; Provisional; Region: PRK07236
595495000067	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
595495000068	hypothetical protein; Provisional; Region: PRK11616
595495000069	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
595495000070	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
595495000071	putative dimer interface [polypeptide binding]; other site
595495000072	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
595495000073	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
595495000074	putative dimer interface [polypeptide binding]; other site
595495000075	putative transporter; Validated; Region: PRK03818
595495000076	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
595495000077	TrkA-C domain; Region: TrkA_C; pfam02080
595495000078	TrkA-C domain; Region: TrkA_C; pfam02080
595495000079	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
595495000080	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
595495000081	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495000082	DNA-binding site [nucleotide binding]; DNA binding site
595495000083	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
595495000084	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
595495000085	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
595495000086	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
595495000087	active site turn [active]
595495000088	phosphorylation site [posttranslational modification]
595495000089	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
595495000090	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495000091	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
595495000092	putative transporter; Provisional; Region: PRK10484
595495000093	uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328
595495000094	Na binding site [ion binding]; other site
595495000095	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
595495000096	Sulfatase; Region: Sulfatase; pfam00884
595495000097	Predicted membrane protein [Function unknown]; Region: COG2149
595495000098	Domain of unknown function (DUF202); Region: DUF202; pfam02656
595495000099	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
595495000100	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
595495000101	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495000102	putative substrate translocation pore; other site
595495000103	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
595495000104	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
595495000105	PYR/PP interface [polypeptide binding]; other site
595495000106	dimer interface [polypeptide binding]; other site
595495000107	TPP binding site [chemical binding]; other site
595495000108	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
595495000109	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
595495000110	TPP-binding site [chemical binding]; other site
595495000111	dimer interface [polypeptide binding]; other site
595495000112	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
595495000113	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
595495000114	putative valine binding site [chemical binding]; other site
595495000115	dimer interface [polypeptide binding]; other site
595495000116	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
595495000117	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495000118	active site
595495000119	phosphorylation site [posttranslational modification]
595495000120	intermolecular recognition site; other site
595495000121	dimerization interface [polypeptide binding]; other site
595495000122	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
595495000123	DNA binding residues [nucleotide binding]
595495000124	dimerization interface [polypeptide binding]; other site
595495000125	sensory histidine kinase UhpB; Provisional; Region: PRK11644
595495000126	MASE1; Region: MASE1; pfam05231
595495000127	Histidine kinase; Region: HisKA_3; pfam07730
595495000128	regulatory protein UhpC; Provisional; Region: PRK11663
595495000129	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495000130	putative substrate translocation pore; other site
595495000131	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
595495000132	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495000133	putative substrate translocation pore; other site
595495000134	cryptic adenine deaminase; Provisional; Region: PRK10027
595495000135	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
595495000136	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
595495000137	active site
595495000138	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
595495000139	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
595495000140	Protein of unknown function (DUF1198); Region: DUF1198; pfam06711
595495000141	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
595495000142	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495000143	putative substrate translocation pore; other site
595495000144	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
595495000145	cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861
595495000146	lipoprotein, YaeC family; Region: TIGR00363
595495000147	EamA-like transporter family; Region: EamA; pfam00892
595495000148	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
595495000149	EamA-like transporter family; Region: EamA; pfam00892
595495000150	sugar efflux transporter; Region: 2A0120; TIGR00899
595495000151	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495000152	putative substrate translocation pore; other site
595495000153	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
595495000154	Protein of unknown function (DUF1219); Region: DUF1219; pfam06755
595495000155	YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154
595495000156	Protein of unknown function (DUF987); Region: DUF987; pfam06174
595495000157	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
595495000158	MPN+ (JAMM) motif; other site
595495000159	Zinc-binding site [ion binding]; other site
595495000160	Domain of unknown function (DUF932); Region: DUF932; pfam06067
595495000161	Transposase; Region: HTH_Tnp_1; cl17663
595495000162	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
595495000163	putative transposase OrfB; Reviewed; Region: PHA02517
595495000164	HTH-like domain; Region: HTH_21; pfam13276
595495000165	Integrase core domain; Region: rve; pfam00665
595495000166	Integrase core domain; Region: rve_2; pfam13333
595495000167	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
595495000168	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
595495000169	AAA ATPase domain; Region: AAA_15; pfam13175
595495000170	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495000171	Walker A/P-loop; other site
595495000172	ATP binding site [chemical binding]; other site
595495000173	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
595495000174	putative active site [active]
595495000175	putative metal-binding site [ion binding]; other site
595495000176	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
595495000177	Part of AAA domain; Region: AAA_19; pfam13245
595495000178	Family description; Region: UvrD_C_2; pfam13538
595495000179	integrase; Provisional; Region: PRK09692
595495000180	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
595495000181	active site
595495000182	Int/Topo IB signature motif; other site
595495000183	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
595495000184	putative transporter; Provisional; Region: PRK11462
595495000185	putative alpha-glucosidase; Provisional; Region: PRK10658
595495000186	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
595495000187	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
595495000188	active site
595495000189	homotrimer interface [polypeptide binding]; other site
595495000190	catalytic site [active]
595495000191	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
595495000192	AsmA family; Region: AsmA; pfam05170
595495000193	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
595495000194	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
595495000195	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
595495000196	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
595495000197	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
595495000198	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
595495000199	generic binding surface II; other site
595495000200	ssDNA binding site; other site
595495000201	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
595495000202	ATP binding site [chemical binding]; other site
595495000203	putative Mg++ binding site [ion binding]; other site
595495000204	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
595495000205	nucleotide binding region [chemical binding]; other site
595495000206	ATP-binding site [chemical binding]; other site
595495000207	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
595495000208	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
595495000209	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
595495000210	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
595495000211	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
595495000212	Zn2+ binding site [ion binding]; other site
595495000213	Mg2+ binding site [ion binding]; other site
595495000214	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
595495000215	synthetase active site [active]
595495000216	NTP binding site [chemical binding]; other site
595495000217	metal binding site [ion binding]; metal-binding site
595495000218	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
595495000219	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
595495000220	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
595495000221	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
595495000222	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
595495000223	catalytic site [active]
595495000224	G-X2-G-X-G-K; other site
595495000225	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
595495000226	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
595495000227	nucleotide binding pocket [chemical binding]; other site
595495000228	K-X-D-G motif; other site
595495000229	catalytic site [active]
595495000230	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
595495000231	Predicted membrane protein [Function unknown]; Region: COG2860
595495000232	UPF0126 domain; Region: UPF0126; pfam03458
595495000233	UPF0126 domain; Region: UPF0126; pfam03458
595495000234	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
595495000235	BRO family, N-terminal domain; Region: Bro-N; pfam02498
595495000236	hypothetical protein; Provisional; Region: PRK11820
595495000237	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
595495000238	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
595495000239	ribonuclease PH; Reviewed; Region: rph; PRK00173
595495000240	Ribonuclease PH; Region: RNase_PH_bact; cd11362
595495000241	hexamer interface [polypeptide binding]; other site
595495000242	active site
595495000243	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
595495000244	active site
595495000245	division inhibitor protein; Provisional; Region: slmA; PRK09480
595495000246	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
595495000247	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
595495000248	trimer interface [polypeptide binding]; other site
595495000249	active site
595495000250	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
595495000251	Flavoprotein; Region: Flavoprotein; pfam02441
595495000252	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
595495000253	hypothetical protein; Reviewed; Region: PRK00024
595495000254	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
595495000255	MPN+ (JAMM) motif; other site
595495000256	Zinc-binding site [ion binding]; other site
595495000257	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
595495000258	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
595495000259	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
595495000260	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
595495000261	DNA binding site [nucleotide binding]
595495000262	catalytic residue [active]
595495000263	H2TH interface [polypeptide binding]; other site
595495000264	putative catalytic residues [active]
595495000265	turnover-facilitating residue; other site
595495000266	intercalation triad [nucleotide binding]; other site
595495000267	8OG recognition residue [nucleotide binding]; other site
595495000268	putative reading head residues; other site
595495000269	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
595495000270	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
595495000271	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
595495000272	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
595495000273	active site
595495000274	(T/H)XGH motif; other site
595495000275	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
595495000276	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
595495000277	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
595495000278	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422
595495000279	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
595495000280	putative active site [active]
595495000281	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
595495000282	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
595495000283	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
595495000284	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
595495000285	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
595495000286	Ligand binding site; other site
595495000287	metal-binding site
595495000288	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
595495000289	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
595495000290	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
595495000291	Ligand binding site; other site
595495000292	metal-binding site
595495000293	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
595495000294	Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176
595495000295	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
595495000296	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
595495000297	Ligand binding site; other site
595495000298	metal-binding site
595495000299	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
595495000300	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
595495000301	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
595495000302	active site
595495000303	O-Antigen ligase; Region: Wzy_C; pfam04932
595495000304	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
595495000305	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
595495000306	putative active site [active]
595495000307	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
595495000308	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
595495000309	putative active site [active]
595495000310	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
595495000311	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
595495000312	NADP binding site [chemical binding]; other site
595495000313	homopentamer interface [polypeptide binding]; other site
595495000314	substrate binding site [chemical binding]; other site
595495000315	active site
595495000316	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
595495000317	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
595495000318	substrate-cofactor binding pocket; other site
595495000319	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495000320	catalytic residue [active]
595495000321	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
595495000322	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
595495000323	NAD(P) binding site [chemical binding]; other site
595495000324	putative glycosyl transferase; Provisional; Region: PRK10073
595495000325	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
595495000326	active site
595495000327	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
595495000328	NodB motif; other site
595495000329	putative active site [active]
595495000330	putative catalytic site [active]
595495000331	Zn binding site [ion binding]; other site
595495000332	AmiB activator; Provisional; Region: PRK11637
595495000333	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
595495000334	Peptidase family M23; Region: Peptidase_M23; pfam01551
595495000335	phosphoglyceromutase; Provisional; Region: PRK05434
595495000336	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
595495000337	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
595495000338	active site residue [active]
595495000339	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
595495000340	GSH binding site [chemical binding]; other site
595495000341	catalytic residues [active]
595495000342	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
595495000343	SecA binding site; other site
595495000344	Preprotein binding site; other site
595495000345	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
595495000346	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
595495000347	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
595495000348	serine acetyltransferase; Provisional; Region: cysE; PRK11132
595495000349	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
595495000350	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
595495000351	trimer interface [polypeptide binding]; other site
595495000352	active site
595495000353	substrate binding site [chemical binding]; other site
595495000354	CoA binding site [chemical binding]; other site
595495000355	putative rRNA methylase; Provisional; Region: PRK10358
595495000356	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
595495000357	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
595495000358	phosphate binding site [ion binding]; other site
595495000359	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
595495000360	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495000361	DNA-binding site [nucleotide binding]; DNA binding site
595495000362	FCD domain; Region: FCD; pfam07729
595495000363	L-lactate permease; Provisional; Region: PRK10420
595495000364	glycolate transporter; Provisional; Region: PRK09695
595495000365	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
595495000366	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
595495000367	trimer interface [polypeptide binding]; other site
595495000368	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
595495000369	trimer interface [polypeptide binding]; other site
595495000370	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
595495000371	Haemagglutinin; Region: HIM; pfam05662
595495000372	Haemagglutinin; Region: HIM; pfam05662
595495000373	YadA-like C-terminal region; Region: YadA; pfam03895
595495000374	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
595495000375	hypothetical protein; Provisional; Region: PRK11020
595495000376	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
595495000377	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
595495000378	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
595495000379	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
595495000380	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
595495000381	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
595495000382	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
595495000383	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
595495000384	active site
595495000385	P-loop; other site
595495000386	phosphorylation site [posttranslational modification]
595495000387	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
595495000388	active site
595495000389	phosphorylation site [posttranslational modification]
595495000390	Protein of unknown function (DUF3302); Region: DUF3302; pfam11742
595495000391	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
595495000392	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
595495000393	HlyD family secretion protein; Region: HlyD_3; pfam13437
595495000394	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
595495000395	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
595495000396	RHS protein; Region: RHS; pfam03527
595495000397	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
595495000398	putative lyase; Provisional; Region: PRK09687
595495000399	PAAR motif; Region: PAAR_motif; cl15808
595495000400	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
595495000401	RHS Repeat; Region: RHS_repeat; pfam05593
595495000402	RHS Repeat; Region: RHS_repeat; pfam05593
595495000403	RHS Repeat; Region: RHS_repeat; cl11982
595495000404	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
595495000405	RHS Repeat; Region: RHS_repeat; pfam05593
595495000406	RHS Repeat; Region: RHS_repeat; pfam05593
595495000407	RHS protein; Region: RHS; pfam03527
595495000408	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
595495000409	Domain of unknown function (DUF4329); Region: DUF4329; pfam14220
595495000410	putative glutathione S-transferase; Provisional; Region: PRK10357
595495000411	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
595495000412	putative C-terminal domain interface [polypeptide binding]; other site
595495000413	putative GSH binding site (G-site) [chemical binding]; other site
595495000414	putative dimer interface [polypeptide binding]; other site
595495000415	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
595495000416	dimer interface [polypeptide binding]; other site
595495000417	N-terminal domain interface [polypeptide binding]; other site
595495000418	putative substrate binding pocket (H-site) [chemical binding]; other site
595495000419	selenocysteine synthase; Provisional; Region: PRK04311
595495000420	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
595495000421	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
595495000422	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
595495000423	catalytic residue [active]
595495000424	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
595495000425	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
595495000426	G1 box; other site
595495000427	putative GEF interaction site [polypeptide binding]; other site
595495000428	GTP/Mg2+ binding site [chemical binding]; other site
595495000429	Switch I region; other site
595495000430	G2 box; other site
595495000431	G3 box; other site
595495000432	Switch II region; other site
595495000433	G4 box; other site
595495000434	G5 box; other site
595495000435	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
595495000436	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
595495000437	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
595495000438	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
595495000439	putative alcohol dehydrogenase; Provisional; Region: PRK09860
595495000440	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
595495000441	dimer interface [polypeptide binding]; other site
595495000442	active site
595495000443	metal binding site [ion binding]; metal-binding site
595495000444	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
595495000445	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
595495000446	NAD(P) binding site [chemical binding]; other site
595495000447	catalytic residues [active]
595495000448	Protein of unknown function (DUF3302); Region: DUF3302; pfam11742
595495000449	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
595495000450	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
595495000451	HlyD family secretion protein; Region: HlyD_3; pfam13437
595495000452	Transcriptional regulator [Transcription]; Region: LysR; COG0583
595495000453	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495000454	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
595495000455	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
595495000456	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
595495000457	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
595495000458	intersubunit interface [polypeptide binding]; other site
595495000459	active site
595495000460	Zn2+ binding site [ion binding]; other site
595495000461	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
595495000462	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
595495000463	AP (apurinic/apyrimidinic) site pocket; other site
595495000464	DNA interaction; other site
595495000465	Metal-binding active site; metal-binding site
595495000466	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
595495000467	active site
595495000468	dimer interface [polypeptide binding]; other site
595495000469	magnesium binding site [ion binding]; other site
595495000470	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
595495000471	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
595495000472	putative N- and C-terminal domain interface [polypeptide binding]; other site
595495000473	putative active site [active]
595495000474	MgATP binding site [chemical binding]; other site
595495000475	catalytic site [active]
595495000476	metal binding site [ion binding]; metal-binding site
595495000477	putative xylulose binding site [chemical binding]; other site
595495000478	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
595495000479	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
595495000480	L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060
595495000481	DctM-like transporters; Region: DctM; pfam06808
595495000482	2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877
595495000483	uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022
595495000484	2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260
595495000485	Transcriptional regulator [Transcription]; Region: IclR; COG1414
595495000486	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
595495000487	Bacterial transcriptional regulator; Region: IclR; pfam01614
595495000488	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
595495000489	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
595495000490	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
595495000491	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
595495000492	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495000493	homodimer interface [polypeptide binding]; other site
595495000494	catalytic residue [active]
595495000495	alpha-amylase; Reviewed; Region: malS; PRK09505
595495000496	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
595495000497	active site
595495000498	catalytic site [active]
595495000499	hypothetical protein; Provisional; Region: PRK10356
595495000500	Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992
595495000501	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
595495000502	putative dimerization interface [polypeptide binding]; other site
595495000503	Transcriptional regulators [Transcription]; Region: PurR; COG1609
595495000504	putative ligand binding site [chemical binding]; other site
595495000505	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495000506	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
595495000507	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495000508	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
595495000509	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
595495000510	TM-ABC transporter signature motif; other site
595495000511	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
595495000512	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
595495000513	Walker A/P-loop; other site
595495000514	ATP binding site [chemical binding]; other site
595495000515	Q-loop/lid; other site
595495000516	ABC transporter signature motif; other site
595495000517	Walker B; other site
595495000518	D-loop; other site
595495000519	H-loop/switch region; other site
595495000520	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
595495000521	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
595495000522	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
595495000523	putative ligand binding site [chemical binding]; other site
595495000524	xylose isomerase; Provisional; Region: PRK05474
595495000525	xylose isomerase; Region: xylose_isom_A; TIGR02630
595495000526	xylulokinase; Provisional; Region: PRK15027
595495000527	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
595495000528	N- and C-terminal domain interface [polypeptide binding]; other site
595495000529	active site
595495000530	MgATP binding site [chemical binding]; other site
595495000531	catalytic site [active]
595495000532	metal binding site [ion binding]; metal-binding site
595495000533	xylulose binding site [chemical binding]; other site
595495000534	homodimer interface [polypeptide binding]; other site
595495000535	hypothetical protein; Provisional; Region: PRK11403
595495000536	yiaA/B two helix domain; Region: YiaAB; pfam05360
595495000537	hypothetical protein; Provisional; Region: PRK11383
595495000538	yiaA/B two helix domain; Region: YiaAB; pfam05360
595495000539	yiaA/B two helix domain; Region: YiaAB; pfam05360
595495000540	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
595495000541	Acyltransferase family; Region: Acyl_transf_3; pfam01757
595495000542	YsaB-like lipoprotein; Region: YsaB; pfam13983
595495000543	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
595495000544	dimer interface [polypeptide binding]; other site
595495000545	motif 1; other site
595495000546	active site
595495000547	motif 2; other site
595495000548	motif 3; other site
595495000549	glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211
595495000550	DALR anticodon binding domain; Region: DALR_1; pfam05746
595495000551	anticodon binding site; other site
595495000552	tRNA binding surface [nucleotide binding]; other site
595495000553	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
595495000554	Helix-turn-helix domain; Region: HTH_28; pfam13518
595495000555	Helix-turn-helix domain; Region: HTH_28; pfam13518
595495000556	putative transposase OrfB; Reviewed; Region: PHA02517
595495000557	HTH-like domain; Region: HTH_21; pfam13276
595495000558	Integrase core domain; Region: rve; pfam00665
595495000559	Integrase core domain; Region: rve_2; pfam13333
595495000560	small toxic polypeptide; Provisional; Region: PRK09759
595495000561	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
595495000562	DNA-binding site [nucleotide binding]; DNA binding site
595495000563	RNA-binding motif; other site
595495000564	Predicted transcriptional regulator [Transcription]; Region: COG2944
595495000565	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
595495000566	non-specific DNA binding site [nucleotide binding]; other site
595495000567	salt bridge; other site
595495000568	sequence-specific DNA binding site [nucleotide binding]; other site
595495000569	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
595495000570	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
595495000571	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
595495000572	dimerization interface [polypeptide binding]; other site
595495000573	ligand binding site [chemical binding]; other site
595495000574	NADP binding site [chemical binding]; other site
595495000575	catalytic site [active]
595495000576	putative outer membrane lipoprotein; Provisional; Region: PRK10510
595495000577	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
595495000578	ligand binding site [chemical binding]; other site
595495000579	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
595495000580	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
595495000581	molybdopterin cofactor binding site [chemical binding]; other site
595495000582	substrate binding site [chemical binding]; other site
595495000583	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
595495000584	molybdopterin cofactor binding site; other site
595495000585	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
595495000586	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
595495000587	Coenzyme A binding pocket [chemical binding]; other site
595495000588	3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353
595495000589	Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571
595495000590	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
595495000591	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495000592	putative substrate translocation pore; other site
595495000593	long polar fimbrial protein LpfA; Provisional; Region: PRK15209
595495000594	long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208
595495000595	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
595495000596	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
595495000597	long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207
595495000598	PapC N-terminal domain; Region: PapC_N; pfam13954
595495000599	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
595495000600	PapC C-terminal domain; Region: PapC_C; pfam13953
595495000601	long polar fimbrial protein LpfD; Provisional; Region: PRK15206
595495000602	long polar fimbrial protein LpfE; Provisional; Region: PRK15205
595495000603	phosphoethanolamine transferase; Provisional; Region: PRK11560
595495000604	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
595495000605	Sulfatase; Region: Sulfatase; pfam00884
595495000606	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
595495000607	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
595495000608	peptide binding site [polypeptide binding]; other site
595495000609	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
595495000610	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495000611	dimer interface [polypeptide binding]; other site
595495000612	conserved gate region; other site
595495000613	putative PBP binding loops; other site
595495000614	ABC-ATPase subunit interface; other site
595495000615	dipeptide transporter; Provisional; Region: PRK10913
595495000616	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
595495000617	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495000618	dimer interface [polypeptide binding]; other site
595495000619	conserved gate region; other site
595495000620	putative PBP binding loops; other site
595495000621	ABC-ATPase subunit interface; other site
595495000622	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
595495000623	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
595495000624	Walker A/P-loop; other site
595495000625	ATP binding site [chemical binding]; other site
595495000626	Q-loop/lid; other site
595495000627	ABC transporter signature motif; other site
595495000628	Walker B; other site
595495000629	D-loop; other site
595495000630	H-loop/switch region; other site
595495000631	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
595495000632	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
595495000633	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
595495000634	Walker A/P-loop; other site
595495000635	ATP binding site [chemical binding]; other site
595495000636	Q-loop/lid; other site
595495000637	ABC transporter signature motif; other site
595495000638	Walker B; other site
595495000639	D-loop; other site
595495000640	H-loop/switch region; other site
595495000641	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
595495000642	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
595495000643	serine transporter; Region: stp; TIGR00814
595495000644	Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940
595495000645	Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940
595495000646	Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940
595495000647	Protein of unknown function (DUF3260); Region: DUF3260; pfam11658
595495000648	celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493
595495000649	cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045
595495000650	Protein of unknown function (DUF2819); Region: DUF2819; pfam10995
595495000651	Protein of unknown function (DUF2629); Region: DUF2629; pfam10945
595495000652	cell division protein; Provisional; Region: PRK10037
595495000653	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
595495000654	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
595495000655	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
595495000656	DXD motif; other site
595495000657	PilZ domain; Region: PilZ; pfam07238
595495000658	cellulose synthase regulator protein; Provisional; Region: PRK11114
595495000659	endo-1,4-D-glucanase; Provisional; Region: PRK11097
595495000660	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
595495000661	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
595495000662	binding surface
595495000663	TPR motif; other site
595495000664	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
595495000665	binding surface
595495000666	TPR motif; other site
595495000667	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
595495000668	putative diguanylate cyclase; Provisional; Region: PRK13561
595495000669	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
595495000670	metal binding site [ion binding]; metal-binding site
595495000671	active site
595495000672	I-site; other site
595495000673	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
595495000674	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
595495000675	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
595495000676	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
595495000677	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
595495000678	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
595495000679	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
595495000680	substrate binding site [chemical binding]; other site
595495000681	ATP binding site [chemical binding]; other site
595495000682	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
595495000683	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
595495000684	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
595495000685	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495000686	metabolite-proton symporter; Region: 2A0106; TIGR00883
595495000687	putative substrate translocation pore; other site
595495000688	inner membrane protein YhjD; Region: TIGR00766
595495000689	Transcriptional regulator [Transcription]; Region: LysR; COG0583
595495000690	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495000691	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
595495000692	putative effector binding pocket; other site
595495000693	putative dimerization interface [polypeptide binding]; other site
595495000694	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
595495000695	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
595495000696	DNA binding residues [nucleotide binding]
595495000697	dimerization interface [polypeptide binding]; other site
595495000698	trehalase; Provisional; Region: treF; PRK13270
595495000699	Trehalase; Region: Trehalase; pfam01204
595495000700	Haem-binding domain; Region: Haem_bd; pfam14376
595495000701	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
595495000702	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
595495000703	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495000704	catalytic residue [active]
595495000705	DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978
595495000706	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495000707	transcriptional regulator YdeO; Provisional; Region: PRK09940
595495000708	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495000709	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
595495000710	Protein export membrane protein; Region: SecD_SecF; cl14618
595495000711	multidrug efflux system protein MdtE; Provisional; Region: PRK09859
595495000712	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
595495000713	HlyD family secretion protein; Region: HlyD_3; pfam13437
595495000714	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
595495000715	pyruvate kinase; Provisional; Region: PRK05826
595495000716	acid-resistance membrane protein; Provisional; Region: PRK10209
595495000717	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
595495000718	acid-resistance protein; Provisional; Region: PRK10208
595495000719	acid-resistance protein; Provisional; Region: hdeB; PRK11566
595495000720	putative Mg(2+) transport ATPase; Provisional; Region: PRK09977
595495000721	MgtC family; Region: MgtC; pfam02308
595495000722	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
595495000723	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
595495000724	DNA binding residues [nucleotide binding]
595495000725	dimerization interface [polypeptide binding]; other site
595495000726	outer membrane lipoprotein, Slp family; Region: slp; TIGR00752
595495000727	Predicted permeases [General function prediction only]; Region: COG0701
595495000728	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
595495000729	dimerization interface [polypeptide binding]; other site
595495000730	putative DNA binding site [nucleotide binding]; other site
595495000731	putative Zn2+ binding site [ion binding]; other site
595495000732	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
595495000733	ArsC family; Region: ArsC; pfam03960
595495000734	catalytic residues [active]
595495000735	arsenical pump membrane protein; Provisional; Region: PRK15445
595495000736	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
595495000737	transmembrane helices; other site
595495000738	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
595495000739	dimerization interface [polypeptide binding]; other site
595495000740	putative DNA binding site [nucleotide binding]; other site
595495000741	putative Zn2+ binding site [ion binding]; other site
595495000742	glutathione reductase; Validated; Region: PRK06116
595495000743	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
595495000744	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
595495000745	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
595495000746	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
595495000747	oligopeptidase A; Provisional; Region: PRK10911
595495000748	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
595495000749	active site
595495000750	Zn binding site [ion binding]; other site
595495000751	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495000752	S-adenosylmethionine binding site [chemical binding]; other site
595495000753	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
595495000754	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495000755	putative substrate translocation pore; other site
595495000756	POT family; Region: PTR2; pfam00854
595495000757	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
595495000758	Ligand Binding Site [chemical binding]; other site
595495000759	universal stress protein UspB; Provisional; Region: PRK04960
595495000760	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
595495000761	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
595495000762	Predicted flavoproteins [General function prediction only]; Region: COG2081
595495000763	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
595495000764	Protein of unknown function (DUF2776); Region: DUF2776; pfam10951
595495000765	Domain of unknown function (DUF4049); Region: DUF4049; pfam13258
595495000766	Domain of unknown function (DUF4049); Region: DUF4049; pfam13258
595495000767	HlyD family secretion protein; Region: HlyD; pfam00529
595495000768	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
595495000769	HlyD family secretion protein; Region: HlyD_3; pfam13437
595495000770	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
595495000771	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
595495000772	Walker A/P-loop; other site
595495000773	ATP binding site [chemical binding]; other site
595495000774	Q-loop/lid; other site
595495000775	ABC transporter signature motif; other site
595495000776	Walker B; other site
595495000777	D-loop; other site
595495000778	H-loop/switch region; other site
595495000779	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
595495000780	Walker A/P-loop; other site
595495000781	ATP binding site [chemical binding]; other site
595495000782	Q-loop/lid; other site
595495000783	ABC transporter signature motif; other site
595495000784	Walker B; other site
595495000785	D-loop; other site
595495000786	H-loop/switch region; other site
595495000787	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
595495000788	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
595495000789	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
595495000790	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
595495000791	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
595495000792	HicB family; Region: HicB; pfam05534
595495000793	nickel responsive regulator; Provisional; Region: PRK02967
595495000794	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
595495000795	nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419
595495000796	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
595495000797	Walker A/P-loop; other site
595495000798	ATP binding site [chemical binding]; other site
595495000799	Q-loop/lid; other site
595495000800	ABC transporter signature motif; other site
595495000801	Walker B; other site
595495000802	D-loop; other site
595495000803	H-loop/switch region; other site
595495000804	nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418
595495000805	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
595495000806	Walker A/P-loop; other site
595495000807	ATP binding site [chemical binding]; other site
595495000808	Q-loop/lid; other site
595495000809	ABC transporter signature motif; other site
595495000810	Walker B; other site
595495000811	D-loop; other site
595495000812	H-loop/switch region; other site
595495000813	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
595495000814	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
595495000815	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495000816	dimer interface [polypeptide binding]; other site
595495000817	conserved gate region; other site
595495000818	putative PBP binding loops; other site
595495000819	ABC-ATPase subunit interface; other site
595495000820	nickel transporter permease NikB; Provisional; Region: PRK10352
595495000821	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495000822	dimer interface [polypeptide binding]; other site
595495000823	conserved gate region; other site
595495000824	putative PBP binding loops; other site
595495000825	ABC-ATPase subunit interface; other site
595495000826	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
595495000827	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
595495000828	substrate binding site [chemical binding]; other site
595495000829	holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351
595495000830	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
595495000831	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
595495000832	Domain of unknown function DUF20; Region: UPF0118; pfam01594
595495000833	major facilitator superfamily transporter; Provisional; Region: PRK05122
595495000834	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495000835	putative substrate translocation pore; other site
595495000836	hypothetical protein; Provisional; Region: PRK11615
595495000837	hypothetical protein; Provisional; Region: PRK11212
595495000838	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
595495000839	CPxP  motif; other site
595495000840	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
595495000841	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
595495000842	metal-binding site [ion binding]
595495000843	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
595495000844	Predicted membrane protein [Function unknown]; Region: COG3714
595495000845	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
595495000846	hypothetical protein; Provisional; Region: PRK10910
595495000847	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
595495000848	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495000849	S-adenosylmethionine binding site [chemical binding]; other site
595495000850	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
595495000851	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
595495000852	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
595495000853	P loop; other site
595495000854	GTP binding site [chemical binding]; other site
595495000855	cell division protein FtsE; Provisional; Region: PRK10908
595495000856	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495000857	Walker A/P-loop; other site
595495000858	ATP binding site [chemical binding]; other site
595495000859	Q-loop/lid; other site
595495000860	ABC transporter signature motif; other site
595495000861	Walker B; other site
595495000862	D-loop; other site
595495000863	H-loop/switch region; other site
595495000864	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
595495000865	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
595495000866	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
595495000867	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
595495000868	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
595495000869	DNA binding residues [nucleotide binding]
595495000870	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
595495000871	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
595495000872	dimerization interface [polypeptide binding]; other site
595495000873	ligand binding site [chemical binding]; other site
595495000874	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
595495000875	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
595495000876	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
595495000877	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
595495000878	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
595495000879	dimerization interface [polypeptide binding]; other site
595495000880	ligand binding site [chemical binding]; other site
595495000881	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
595495000882	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
595495000883	TM-ABC transporter signature motif; other site
595495000884	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
595495000885	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
595495000886	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
595495000887	TM-ABC transporter signature motif; other site
595495000888	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
595495000889	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
595495000890	Walker A/P-loop; other site
595495000891	ATP binding site [chemical binding]; other site
595495000892	Q-loop/lid; other site
595495000893	ABC transporter signature motif; other site
595495000894	Walker B; other site
595495000895	D-loop; other site
595495000896	H-loop/switch region; other site
595495000897	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
595495000898	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
595495000899	Walker A/P-loop; other site
595495000900	ATP binding site [chemical binding]; other site
595495000901	Q-loop/lid; other site
595495000902	ABC transporter signature motif; other site
595495000903	Walker B; other site
595495000904	D-loop; other site
595495000905	H-loop/switch region; other site
595495000906	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
595495000907	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
595495000908	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
595495000909	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495000910	dimer interface [polypeptide binding]; other site
595495000911	conserved gate region; other site
595495000912	putative PBP binding loops; other site
595495000913	ABC-ATPase subunit interface; other site
595495000914	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
595495000915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495000916	dimer interface [polypeptide binding]; other site
595495000917	conserved gate region; other site
595495000918	putative PBP binding loops; other site
595495000919	ABC-ATPase subunit interface; other site
595495000920	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
595495000921	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
595495000922	Walker A/P-loop; other site
595495000923	ATP binding site [chemical binding]; other site
595495000924	Q-loop/lid; other site
595495000925	ABC transporter signature motif; other site
595495000926	Walker B; other site
595495000927	D-loop; other site
595495000928	H-loop/switch region; other site
595495000929	TOBE domain; Region: TOBE_2; pfam08402
595495000930	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
595495000931	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
595495000932	putative active site [active]
595495000933	catalytic site [active]
595495000934	putative metal binding site [ion binding]; other site
595495000935	hypothetical protein; Provisional; Region: PRK10350
595495000936	gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615
595495000937	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
595495000938	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
595495000939	putative acetyltransferase YhhY; Provisional; Region: PRK10140
595495000940	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
595495000941	Coenzyme A binding pocket [chemical binding]; other site
595495000942	putative oxidoreductase; Provisional; Region: PRK10206
595495000943	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
595495000944	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
595495000945	Pirin-related protein [General function prediction only]; Region: COG1741
595495000946	Pirin; Region: Pirin; pfam02678
595495000947	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
595495000948	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
595495000949	DNA binding site [nucleotide binding]
595495000950	domain linker motif; other site
595495000951	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
595495000952	putative ligand binding site [chemical binding]; other site
595495000953	putative dimerization interface [polypeptide binding]; other site
595495000954	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
595495000955	ATP-binding site [chemical binding]; other site
595495000956	Gluconate-6-phosphate binding site [chemical binding]; other site
595495000957	Shikimate kinase; Region: SKI; pfam01202
595495000958	low affinity gluconate transporter; Provisional; Region: PRK10472
595495000959	gluconate transporter; Region: gntP; TIGR00791
595495000960	putative antibiotic transporter; Provisional; Region: PRK10739
595495000961	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
595495000962	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
595495000963	glycogen branching enzyme; Provisional; Region: PRK05402
595495000964	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
595495000965	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
595495000966	active site
595495000967	catalytic site [active]
595495000968	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
595495000969	glycogen debranching enzyme; Provisional; Region: PRK03705
595495000970	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
595495000971	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
595495000972	active site
595495000973	catalytic site [active]
595495000974	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
595495000975	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
595495000976	ligand binding site; other site
595495000977	oligomer interface; other site
595495000978	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
595495000979	sulfate 1 binding site; other site
595495000980	glycogen synthase; Provisional; Region: glgA; PRK00654
595495000981	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
595495000982	ADP-binding pocket [chemical binding]; other site
595495000983	homodimer interface [polypeptide binding]; other site
595495000984	glycogen phosphorylase; Provisional; Region: PRK14986
595495000985	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
595495000986	homodimer interface [polypeptide binding]; other site
595495000987	active site pocket [active]
595495000988	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
595495000989	hypothetical protein; Provisional; Region: PRK09781; cl08057
595495000990	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
595495000991	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
595495000992	active site residue [active]
595495000993	intramembrane serine protease GlpG; Provisional; Region: PRK10907
595495000994	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
595495000995	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
595495000996	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
595495000997	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
595495000998	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
595495000999	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
595495001000	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
595495001001	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495001002	Walker A motif; other site
595495001003	ATP binding site [chemical binding]; other site
595495001004	Walker B motif; other site
595495001005	arginine finger; other site
595495001006	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
595495001007	hypothetical protein; Reviewed; Region: PRK09588
595495001008	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
595495001009	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
595495001010	putative active site [active]
595495001011	transcriptional regulator MalT; Provisional; Region: PRK04841
595495001012	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
595495001013	DNA binding residues [nucleotide binding]
595495001014	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
595495001015	4-alpha-glucanotransferase; Region: malQ; TIGR00217
595495001016	high-affinity gluconate transporter; Provisional; Region: PRK14984
595495001017	gluconate transporter; Region: gntP; TIGR00791
595495001018	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
595495001019	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
595495001020	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
595495001021	DNA utilization protein GntX; Provisional; Region: PRK11595
595495001022	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
595495001023	active site
595495001024	carboxylesterase BioH; Provisional; Region: PRK10349
595495001025	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
595495001026	ferrous iron transport protein FeoC; Provisional; Region: PRK15431
595495001027	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
595495001028	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
595495001029	G1 box; other site
595495001030	GTP/Mg2+ binding site [chemical binding]; other site
595495001031	Switch I region; other site
595495001032	G2 box; other site
595495001033	G3 box; other site
595495001034	Switch II region; other site
595495001035	G4 box; other site
595495001036	G5 box; other site
595495001037	Nucleoside recognition; Region: Gate; pfam07670
595495001038	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
595495001039	Nucleoside recognition; Region: Gate; pfam07670
595495001040	ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555
595495001041	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
595495001042	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
595495001043	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
595495001044	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
595495001045	RNA binding site [nucleotide binding]; other site
595495001046	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
595495001047	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
595495001048	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
595495001049	osmolarity response regulator; Provisional; Region: ompR; PRK09468
595495001050	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495001051	active site
595495001052	phosphorylation site [posttranslational modification]
595495001053	intermolecular recognition site; other site
595495001054	dimerization interface [polypeptide binding]; other site
595495001055	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
595495001056	DNA binding site [nucleotide binding]
595495001057	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
595495001058	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
595495001059	dimerization interface [polypeptide binding]; other site
595495001060	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
595495001061	dimer interface [polypeptide binding]; other site
595495001062	phosphorylation site [posttranslational modification]
595495001063	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495001064	ATP binding site [chemical binding]; other site
595495001065	G-X-G motif; other site
595495001066	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
595495001067	non-specific DNA binding site [nucleotide binding]; other site
595495001068	salt bridge; other site
595495001069	sequence-specific DNA binding site [nucleotide binding]; other site
595495001070	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
595495001071	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
595495001072	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
595495001073	active site
595495001074	substrate-binding site [chemical binding]; other site
595495001075	metal-binding site [ion binding]
595495001076	ATP binding site [chemical binding]; other site
595495001077	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
595495001078	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
595495001079	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
595495001080	dimerization interface [polypeptide binding]; other site
595495001081	domain crossover interface; other site
595495001082	redox-dependent activation switch; other site
595495001083	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
595495001084	RNA binding surface [nucleotide binding]; other site
595495001085	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
595495001086	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495001087	motif II; other site
595495001088	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
595495001089	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
595495001090	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
595495001091	ADP-ribose binding site [chemical binding]; other site
595495001092	dimer interface [polypeptide binding]; other site
595495001093	active site
595495001094	nudix motif; other site
595495001095	metal binding site [ion binding]; metal-binding site
595495001096	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
595495001097	Transglycosylase; Region: Transgly; pfam00912
595495001098	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
595495001099	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
595495001100	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
595495001101	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
595495001102	Protein of unknown function (DUF2531); Region: DUF2531; pfam10748
595495001103	outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560
595495001104	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
595495001105	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
595495001106	shikimate kinase; Reviewed; Region: aroK; PRK00131
595495001107	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
595495001108	ADP binding site [chemical binding]; other site
595495001109	magnesium binding site [ion binding]; other site
595495001110	putative shikimate binding site; other site
595495001111	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
595495001112	active site
595495001113	dimer interface [polypeptide binding]; other site
595495001114	metal binding site [ion binding]; metal-binding site
595495001115	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266
595495001116	cell division protein DamX; Validated; Region: PRK10905
595495001117	DNA adenine methylase; Provisional; Region: PRK10904
595495001118	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
595495001119	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
595495001120	substrate binding site [chemical binding]; other site
595495001121	hexamer interface [polypeptide binding]; other site
595495001122	metal binding site [ion binding]; metal-binding site
595495001123	phosphoglycolate phosphatase; Provisional; Region: PRK13222
595495001124	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495001125	motif II; other site
595495001126	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
595495001127	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
595495001128	active site
595495001129	HIGH motif; other site
595495001130	dimer interface [polypeptide binding]; other site
595495001131	KMSKS motif; other site
595495001132	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
595495001133	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811
595495001134	dimer interface [polypeptide binding]; other site
595495001135	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
595495001136	active site
595495001137	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
595495001138	substrate binding site [chemical binding]; other site
595495001139	catalytic residue [active]
595495001140	putative mutase; Provisional; Region: PRK12383
595495001141	Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015
595495001142	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
595495001143	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
595495001144	active site
595495001145	substrate binding pocket [chemical binding]; other site
595495001146	homodimer interaction site [polypeptide binding]; other site
595495001147	Protein of unknown function DUF2620; Region: DUF2620; pfam10941
595495001148	Protein of unknown function; Region: YhfT; pfam10797
595495001149	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
595495001150	DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056
595495001151	DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402
595495001152	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495001153	DNA-binding site [nucleotide binding]; DNA binding site
595495001154	UTRA domain; Region: UTRA; pfam07702
595495001155	Fructoselysine kinase-like.  Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940
595495001156	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
595495001157	substrate binding site [chemical binding]; other site
595495001158	ATP binding site [chemical binding]; other site
595495001159	fructoselysine 3-epimerase; Provisional; Region: PRK09856
595495001160	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
595495001161	AP (apurinic/apyrimidinic) site pocket; other site
595495001162	DNA interaction; other site
595495001163	Metal-binding active site; metal-binding site
595495001164	fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382
595495001165	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
595495001166	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
595495001167	dimer interface [polypeptide binding]; other site
595495001168	active site
595495001169	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
595495001170	hypothetical protein; Provisional; Region: PHA02764
595495001171	Protein of unknown function (DUF4223); Region: DUF4223; pfam13978
595495001172	siroheme synthase; Provisional; Region: cysG; PRK10637
595495001173	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
595495001174	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
595495001175	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
595495001176	active site
595495001177	SAM binding site [chemical binding]; other site
595495001178	homodimer interface [polypeptide binding]; other site
595495001179	nitrite transporter NirC; Provisional; Region: PRK11562
595495001180	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
595495001181	nitrite reductase subunit NirD; Provisional; Region: PRK14989
595495001182	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
595495001183	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
595495001184	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
595495001185	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
595495001186	putative transporter; Provisional; Region: PRK03699
595495001187	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495001188	putative substrate translocation pore; other site
595495001189	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
595495001190	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
595495001191	substrate binding site [chemical binding]; other site
595495001192	hypothetical protein; Provisional; Region: PRK10204
595495001193	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
595495001194	cell filamentation protein Fic; Provisional; Region: PRK10347
595495001195	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
595495001196	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
595495001197	glutamine binding [chemical binding]; other site
595495001198	catalytic triad [active]
595495001199	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
595495001200	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
595495001201	inhibitor-cofactor binding pocket; inhibition site
595495001202	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495001203	catalytic residue [active]
595495001204	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
595495001205	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
595495001206	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
595495001207	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
595495001208	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
595495001209	ligand binding site [chemical binding]; other site
595495001210	flexible hinge region; other site
595495001211	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
595495001212	putative switch regulator; other site
595495001213	non-specific DNA interactions [nucleotide binding]; other site
595495001214	DNA binding site [nucleotide binding]
595495001215	sequence specific DNA binding site [nucleotide binding]; other site
595495001216	putative cAMP binding site [chemical binding]; other site
595495001217	hypothetical protein; Provisional; Region: PRK10738
595495001218	Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029
595495001219	active site
595495001220	hypothetical protein; Provisional; Region: PRK04966
595495001221	putative hydrolase; Provisional; Region: PRK10985
595495001222	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
595495001223	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495001224	Walker A/P-loop; other site
595495001225	ATP binding site [chemical binding]; other site
595495001226	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
595495001227	ABC transporter signature motif; other site
595495001228	Walker B; other site
595495001229	D-loop; other site
595495001230	ABC transporter; Region: ABC_tran_2; pfam12848
595495001231	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
595495001232	glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930
595495001233	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
595495001234	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
595495001235	TrkA-N domain; Region: TrkA_N; pfam02254
595495001236	Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529
595495001237	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
595495001238	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
595495001239	phi X174 lysis protein; Provisional; Region: PRK02793
595495001240	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
595495001241	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
595495001242	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
595495001243	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
595495001244	YheO-like PAS domain; Region: PAS_6; pfam08348
595495001245	HTH domain; Region: HTH_22; pfam13309
595495001246	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
595495001247	sulfur relay protein TusC; Validated; Region: PRK00211
595495001248	sulfur transfer complex subunit TusB; Provisional; Region: PRK13510
595495001249	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
595495001250	S17 interaction site [polypeptide binding]; other site
595495001251	S8 interaction site; other site
595495001252	16S rRNA interaction site [nucleotide binding]; other site
595495001253	streptomycin interaction site [chemical binding]; other site
595495001254	23S rRNA interaction site [nucleotide binding]; other site
595495001255	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
595495001256	30S ribosomal protein S7; Validated; Region: PRK05302
595495001257	elongation factor G; Reviewed; Region: PRK00007
595495001258	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
595495001259	G1 box; other site
595495001260	putative GEF interaction site [polypeptide binding]; other site
595495001261	GTP/Mg2+ binding site [chemical binding]; other site
595495001262	Switch I region; other site
595495001263	G2 box; other site
595495001264	G3 box; other site
595495001265	Switch II region; other site
595495001266	G4 box; other site
595495001267	G5 box; other site
595495001268	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
595495001269	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
595495001270	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
595495001271	elongation factor Tu; Reviewed; Region: PRK00049
595495001272	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
595495001273	G1 box; other site
595495001274	GEF interaction site [polypeptide binding]; other site
595495001275	GTP/Mg2+ binding site [chemical binding]; other site
595495001276	Switch I region; other site
595495001277	G2 box; other site
595495001278	G3 box; other site
595495001279	Switch II region; other site
595495001280	G4 box; other site
595495001281	G5 box; other site
595495001282	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
595495001283	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
595495001284	Antibiotic Binding Site [chemical binding]; other site
595495001285	bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509
595495001286	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
595495001287	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
595495001288	heme binding site [chemical binding]; other site
595495001289	ferroxidase pore; other site
595495001290	ferroxidase diiron center [ion binding]; other site
595495001291	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
595495001292	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
595495001293	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
595495001294	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
595495001295	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
595495001296	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
595495001297	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
595495001298	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
595495001299	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
595495001300	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
595495001301	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
595495001302	protein-rRNA interface [nucleotide binding]; other site
595495001303	putative translocon binding site; other site
595495001304	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
595495001305	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
595495001306	G-X-X-G motif; other site
595495001307	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
595495001308	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
595495001309	23S rRNA interface [nucleotide binding]; other site
595495001310	5S rRNA interface [nucleotide binding]; other site
595495001311	putative antibiotic binding site [chemical binding]; other site
595495001312	L25 interface [polypeptide binding]; other site
595495001313	L27 interface [polypeptide binding]; other site
595495001314	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
595495001315	23S rRNA interface [nucleotide binding]; other site
595495001316	putative translocon interaction site; other site
595495001317	signal recognition particle (SRP54) interaction site; other site
595495001318	L23 interface [polypeptide binding]; other site
595495001319	trigger factor interaction site; other site
595495001320	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
595495001321	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
595495001322	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
595495001323	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
595495001324	RNA binding site [nucleotide binding]; other site
595495001325	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
595495001326	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
595495001327	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
595495001328	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
595495001329	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
595495001330	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
595495001331	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
595495001332	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
595495001333	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
595495001334	23S rRNA interface [nucleotide binding]; other site
595495001335	5S rRNA interface [nucleotide binding]; other site
595495001336	L27 interface [polypeptide binding]; other site
595495001337	L5 interface [polypeptide binding]; other site
595495001338	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
595495001339	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
595495001340	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
595495001341	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
595495001342	23S rRNA binding site [nucleotide binding]; other site
595495001343	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
595495001344	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
595495001345	SecY translocase; Region: SecY; pfam00344
595495001346	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
595495001347	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
595495001348	30S ribosomal protein S13; Region: bact_S13; TIGR03631
595495001349	30S ribosomal protein S11; Validated; Region: PRK05309
595495001350	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
595495001351	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
595495001352	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
595495001353	RNA binding surface [nucleotide binding]; other site
595495001354	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
595495001355	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
595495001356	alphaNTD homodimer interface [polypeptide binding]; other site
595495001357	alphaNTD - beta interaction site [polypeptide binding]; other site
595495001358	alphaNTD - beta' interaction site [polypeptide binding]; other site
595495001359	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
595495001360	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
595495001361	hypothetical protein; Provisional; Region: PRK10203
595495001362	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
595495001363	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
595495001364	DNA binding residues [nucleotide binding]
595495001365	dimer interface [polypeptide binding]; other site
595495001366	metal binding site [ion binding]; metal-binding site
595495001367	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036
595495001368	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
595495001369	Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741
595495001370	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
595495001371	TrkA-N domain; Region: TrkA_N; pfam02254
595495001372	TrkA-C domain; Region: TrkA_C; pfam02080
595495001373	TrkA-N domain; Region: TrkA_N; pfam02254
595495001374	TrkA-C domain; Region: TrkA_C; pfam02080
595495001375	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
595495001376	putative RNA binding site [nucleotide binding]; other site
595495001377	16S rRNA methyltransferase B; Provisional; Region: PRK10901
595495001378	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495001379	S-adenosylmethionine binding site [chemical binding]; other site
595495001380	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
595495001381	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
595495001382	putative active site [active]
595495001383	substrate binding site [chemical binding]; other site
595495001384	putative cosubstrate binding site; other site
595495001385	catalytic site [active]
595495001386	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
595495001387	substrate binding site [chemical binding]; other site
595495001388	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
595495001389	active site
595495001390	catalytic residues [active]
595495001391	metal binding site [ion binding]; metal-binding site
595495001392	hypothetical protein; Provisional; Region: PRK10736
595495001393	DNA protecting protein DprA; Region: dprA; TIGR00732
595495001394	hypothetical protein; Validated; Region: PRK03430
595495001395	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
595495001396	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
595495001397	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
595495001398	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
595495001399	tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634
595495001400	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
595495001401	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
595495001402	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
595495001403	shikimate binding site; other site
595495001404	NAD(P) binding site [chemical binding]; other site
595495001405	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
595495001406	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
595495001407	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
595495001408	trimer interface [polypeptide binding]; other site
595495001409	putative metal binding site [ion binding]; other site
595495001410	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
595495001411	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
595495001412	Walker A/P-loop; other site
595495001413	ATP binding site [chemical binding]; other site
595495001414	Q-loop/lid; other site
595495001415	ABC transporter signature motif; other site
595495001416	Walker B; other site
595495001417	D-loop; other site
595495001418	H-loop/switch region; other site
595495001419	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
595495001420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495001421	dimer interface [polypeptide binding]; other site
595495001422	conserved gate region; other site
595495001423	putative PBP binding loops; other site
595495001424	ABC-ATPase subunit interface; other site
595495001425	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
595495001426	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495001427	conserved gate region; other site
595495001428	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495001429	dimer interface [polypeptide binding]; other site
595495001430	conserved gate region; other site
595495001431	putative PBP binding loops; other site
595495001432	ABC-ATPase subunit interface; other site
595495001433	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
595495001434	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
595495001435	substrate binding pocket [chemical binding]; other site
595495001436	membrane-bound complex binding site; other site
595495001437	hinge residues; other site
595495001438	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
595495001439	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
595495001440	Protein export membrane protein; Region: SecD_SecF; cl14618
595495001441	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
595495001442	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
595495001443	HlyD family secretion protein; Region: HlyD_3; pfam13437
595495001444	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
595495001445	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
595495001446	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
595495001447	Protein of unknown function (DUF2556); Region: DUF2556; pfam10831
595495001448	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
595495001449	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495001450	DNA methylase; Region: N6_N4_Mtase; pfam01555
595495001451	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
595495001452	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
595495001453	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
595495001454	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
595495001455	FMN binding site [chemical binding]; other site
595495001456	active site
595495001457	catalytic residues [active]
595495001458	substrate binding site [chemical binding]; other site
595495001459	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
595495001460	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
595495001461	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
595495001462	Na binding site [ion binding]; other site
595495001463	hypothetical protein; Provisional; Region: PRK10633
595495001464	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
595495001465	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
595495001466	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
595495001467	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
595495001468	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
595495001469	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
595495001470	carboxyltransferase (CT) interaction site; other site
595495001471	biotinylation site [posttranslational modification]; other site
595495001472	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
595495001473	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
595495001474	NADP binding site [chemical binding]; other site
595495001475	dimer interface [polypeptide binding]; other site
595495001476	regulatory protein CsrD; Provisional; Region: PRK11059
595495001477	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
595495001478	metal binding site [ion binding]; metal-binding site
595495001479	active site
595495001480	I-site; other site
595495001481	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
595495001482	rod shape-determining protein MreB; Provisional; Region: PRK13927
595495001483	MreB and similar proteins; Region: MreB_like; cd10225
595495001484	nucleotide binding site [chemical binding]; other site
595495001485	Mg binding site [ion binding]; other site
595495001486	putative protofilament interaction site [polypeptide binding]; other site
595495001487	RodZ interaction site [polypeptide binding]; other site
595495001488	rod shape-determining protein MreC; Region: mreC; TIGR00219
595495001489	rod shape-determining protein MreC; Region: MreC; pfam04085
595495001490	rod shape-determining protein MreD; Provisional; Region: PRK11060
595495001491	Maf-like protein; Region: Maf; pfam02545
595495001492	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
595495001493	active site
595495001494	dimer interface [polypeptide binding]; other site
595495001495	ribonuclease G; Provisional; Region: PRK11712
595495001496	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
595495001497	homodimer interface [polypeptide binding]; other site
595495001498	oligonucleotide binding site [chemical binding]; other site
595495001499	hypothetical protein; Provisional; Region: PRK10899
595495001500	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
595495001501	protease TldD; Provisional; Region: tldD; PRK10735
595495001502	transcriptional regulator; Provisional; Region: PRK10632
595495001503	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495001504	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
595495001505	putative effector binding pocket; other site
595495001506	dimerization interface [polypeptide binding]; other site
595495001507	efflux system membrane protein; Provisional; Region: PRK11594
595495001508	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
595495001509	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
595495001510	HlyD family secretion protein; Region: HlyD_3; pfam13437
595495001511	p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631
595495001512	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
595495001513	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
595495001514	RNAase interaction site [polypeptide binding]; other site
595495001515	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
595495001516	arginine repressor; Provisional; Region: PRK05066
595495001517	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
595495001518	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
595495001519	malate dehydrogenase; Provisional; Region: PRK05086
595495001520	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
595495001521	NAD binding site [chemical binding]; other site
595495001522	dimerization interface [polypeptide binding]; other site
595495001523	Substrate binding site [chemical binding]; other site
595495001524	serine endoprotease; Provisional; Region: PRK10898
595495001525	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
595495001526	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
595495001527	serine endoprotease; Provisional; Region: PRK10139
595495001528	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
595495001529	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
595495001530	protein binding site [polypeptide binding]; other site
595495001531	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
595495001532	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
595495001533	hypothetical protein; Provisional; Region: PRK11677
595495001534	Predicted ATPase [General function prediction only]; Region: COG1485
595495001535	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
595495001536	23S rRNA interface [nucleotide binding]; other site
595495001537	L3 interface [polypeptide binding]; other site
595495001538	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
595495001539	stringent starvation protein A; Provisional; Region: sspA; PRK09481
595495001540	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
595495001541	C-terminal domain interface [polypeptide binding]; other site
595495001542	putative GSH binding site (G-site) [chemical binding]; other site
595495001543	dimer interface [polypeptide binding]; other site
595495001544	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
595495001545	dimer interface [polypeptide binding]; other site
595495001546	N-terminal domain interface [polypeptide binding]; other site
595495001547	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
595495001548	putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804
595495001549	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
595495001550	transcriptional regulator NanR; Provisional; Region: PRK03837
595495001551	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495001552	DNA-binding site [nucleotide binding]; DNA binding site
595495001553	FCD domain; Region: FCD; pfam07729
595495001554	N-acetylneuraminate lyase; Region: nanA; TIGR00683
595495001555	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
595495001556	inhibitor site; inhibition site
595495001557	active site
595495001558	dimer interface [polypeptide binding]; other site
595495001559	catalytic residue [active]
595495001560	putative sialic acid transporter; Provisional; Region: PRK03893
595495001561	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495001562	putative substrate translocation pore; other site
595495001563	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
595495001564	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
595495001565	putative active site cavity [active]
595495001566	N-acetylmannosamine kinase; Provisional; Region: PRK05082
595495001567	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
595495001568	nucleotide binding site [chemical binding]; other site
595495001569	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
595495001570	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
595495001571	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
595495001572	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
595495001573	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
595495001574	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
595495001575	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
595495001576	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
595495001577	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
595495001578	active site
595495001579	dimer interface [polypeptide binding]; other site
595495001580	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
595495001581	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
595495001582	active site
595495001583	FMN binding site [chemical binding]; other site
595495001584	substrate binding site [chemical binding]; other site
595495001585	3Fe-4S cluster binding site [ion binding]; other site
595495001586	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
595495001587	domain interface; other site
595495001588	radical SAM protein, TIGR01212 family; Region: TIGR01212
595495001589	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
595495001590	FeS/SAM binding site; other site
595495001591	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
595495001592	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
595495001593	putative active site [active]
595495001594	heme pocket [chemical binding]; other site
595495001595	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
595495001596	dimer interface [polypeptide binding]; other site
595495001597	phosphorylation site [posttranslational modification]
595495001598	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495001599	ATP binding site [chemical binding]; other site
595495001600	Mg2+ binding site [ion binding]; other site
595495001601	G-X-G motif; other site
595495001602	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495001603	active site
595495001604	phosphorylation site [posttranslational modification]
595495001605	intermolecular recognition site; other site
595495001606	dimerization interface [polypeptide binding]; other site
595495001607	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
595495001608	putative binding surface; other site
595495001609	active site
595495001610	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
595495001611	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
595495001612	conserved cys residue [active]
595495001613	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
595495001614	Transglycosylase; Region: Transgly; cl17702
595495001615	hypothetical protein; Provisional; Region: PRK10345
595495001616	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
595495001617	dimerization domain swap beta strand [polypeptide binding]; other site
595495001618	regulatory protein interface [polypeptide binding]; other site
595495001619	active site
595495001620	regulatory phosphorylation site [posttranslational modification]; other site
595495001621	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
595495001622	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
595495001623	active site
595495001624	phosphorylation site [posttranslational modification]
595495001625	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
595495001626	30S subunit binding site; other site
595495001627	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
595495001628	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
595495001629	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
595495001630	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
595495001631	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
595495001632	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
595495001633	Walker A/P-loop; other site
595495001634	ATP binding site [chemical binding]; other site
595495001635	Q-loop/lid; other site
595495001636	ABC transporter signature motif; other site
595495001637	Walker B; other site
595495001638	D-loop; other site
595495001639	H-loop/switch region; other site
595495001640	lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894
595495001641	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
595495001642	lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893
595495001643	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
595495001644	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
595495001645	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
595495001646	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
595495001647	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
595495001648	putative active site [active]
595495001649	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
595495001650	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
595495001651	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
595495001652	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
595495001653	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
595495001654	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
595495001655	Walker A/P-loop; other site
595495001656	ATP binding site [chemical binding]; other site
595495001657	Q-loop/lid; other site
595495001658	ABC transporter signature motif; other site
595495001659	Walker B; other site
595495001660	D-loop; other site
595495001661	H-loop/switch region; other site
595495001662	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
595495001663	conserved hypothetical integral membrane protein; Region: TIGR00056
595495001664	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
595495001665	mce related protein; Region: MCE; pfam02470
595495001666	ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117
595495001667	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
595495001668	anti sigma factor interaction site; other site
595495001669	regulatory phosphorylation site [posttranslational modification]; other site
595495001670	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
595495001671	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
595495001672	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
595495001673	hinge; other site
595495001674	active site
595495001675	DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344
595495001676	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
595495001677	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
595495001678	substrate binding pocket [chemical binding]; other site
595495001679	chain length determination region; other site
595495001680	substrate-Mg2+ binding site; other site
595495001681	catalytic residues [active]
595495001682	aspartate-rich region 1; other site
595495001683	active site lid residues [active]
595495001684	aspartate-rich region 2; other site
595495001685	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
595495001686	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
595495001687	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
595495001688	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
595495001689	EamA-like transporter family; Region: EamA; pfam00892
595495001690	EamA-like transporter family; Region: EamA; pfam00892
595495001691	GTPase CgtA; Reviewed; Region: obgE; PRK12298
595495001692	GTP1/OBG; Region: GTP1_OBG; pfam01018
595495001693	Obg GTPase; Region: Obg; cd01898
595495001694	G1 box; other site
595495001695	GTP/Mg2+ binding site [chemical binding]; other site
595495001696	Switch I region; other site
595495001697	G2 box; other site
595495001698	G3 box; other site
595495001699	Switch II region; other site
595495001700	G4 box; other site
595495001701	G5 box; other site
595495001702	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
595495001703	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
595495001704	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
595495001705	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
595495001706	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
595495001707	RNA-binding protein YhbY; Provisional; Region: PRK10343
595495001708	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
595495001709	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495001710	S-adenosylmethionine binding site [chemical binding]; other site
595495001711	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
595495001712	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495001713	Walker A motif; other site
595495001714	ATP binding site [chemical binding]; other site
595495001715	Walker B motif; other site
595495001716	arginine finger; other site
595495001717	Peptidase family M41; Region: Peptidase_M41; pfam01434
595495001718	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
595495001719	dihydropteroate synthase; Region: DHPS; TIGR01496
595495001720	substrate binding pocket [chemical binding]; other site
595495001721	dimer interface [polypeptide binding]; other site
595495001722	inhibitor binding site; inhibition site
595495001723	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
595495001724	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
595495001725	active site
595495001726	substrate binding site [chemical binding]; other site
595495001727	metal binding site [ion binding]; metal-binding site
595495001728	Preprotein translocase SecG subunit; Region: SecG; pfam03840
595495001729	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
595495001730	Sulfatase; Region: Sulfatase; pfam00884
595495001731	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
595495001732	ANP binding site [chemical binding]; other site
595495001733	Substrate Binding Site II [chemical binding]; other site
595495001734	Substrate Binding Site I [chemical binding]; other site
595495001735	ribosome maturation protein RimP; Reviewed; Region: PRK00092
595495001736	Sm and related proteins; Region: Sm_like; cl00259
595495001737	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
595495001738	putative oligomer interface [polypeptide binding]; other site
595495001739	putative RNA binding site [nucleotide binding]; other site
595495001740	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
595495001741	NusA N-terminal domain; Region: NusA_N; pfam08529
595495001742	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
595495001743	RNA binding site [nucleotide binding]; other site
595495001744	homodimer interface [polypeptide binding]; other site
595495001745	NusA-like KH domain; Region: KH_5; pfam13184
595495001746	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
595495001747	G-X-X-G motif; other site
595495001748	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
595495001749	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
595495001750	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
595495001751	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
595495001752	translation initiation factor IF-2; Region: IF-2; TIGR00487
595495001753	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
595495001754	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
595495001755	G1 box; other site
595495001756	putative GEF interaction site [polypeptide binding]; other site
595495001757	GTP/Mg2+ binding site [chemical binding]; other site
595495001758	Switch I region; other site
595495001759	G2 box; other site
595495001760	G3 box; other site
595495001761	Switch II region; other site
595495001762	G4 box; other site
595495001763	G5 box; other site
595495001764	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
595495001765	Translation-initiation factor 2; Region: IF-2; pfam11987
595495001766	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
595495001767	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
595495001768	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
595495001769	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
595495001770	RNA binding site [nucleotide binding]; other site
595495001771	active site
595495001772	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
595495001773	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
595495001774	16S/18S rRNA binding site [nucleotide binding]; other site
595495001775	S13e-L30e interaction site [polypeptide binding]; other site
595495001776	25S rRNA binding site [nucleotide binding]; other site
595495001777	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
595495001778	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
595495001779	RNase E interface [polypeptide binding]; other site
595495001780	trimer interface [polypeptide binding]; other site
595495001781	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
595495001782	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
595495001783	RNase E interface [polypeptide binding]; other site
595495001784	trimer interface [polypeptide binding]; other site
595495001785	active site
595495001786	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
595495001787	putative nucleic acid binding region [nucleotide binding]; other site
595495001788	G-X-X-G motif; other site
595495001789	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
595495001790	RNA binding site [nucleotide binding]; other site
595495001791	domain interface; other site
595495001792	lipoprotein NlpI; Provisional; Region: PRK11189
595495001793	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
595495001794	binding surface
595495001795	TPR motif; other site
595495001796	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
595495001797	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
595495001798	ATP binding site [chemical binding]; other site
595495001799	Mg++ binding site [ion binding]; other site
595495001800	motif III; other site
595495001801	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
595495001802	nucleotide binding region [chemical binding]; other site
595495001803	ATP-binding site [chemical binding]; other site
595495001804	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
595495001805	putative RNA binding site [nucleotide binding]; other site
595495001806	tryptophan permease; Provisional; Region: PRK10483
595495001807	aromatic amino acid transport protein; Region: araaP; TIGR00837
595495001808	hypothetical protein; Provisional; Region: PRK10508
595495001809	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
595495001810	putative protease; Provisional; Region: PRK15447
595495001811	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
595495001812	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
595495001813	Peptidase family U32; Region: Peptidase_U32; pfam01136
595495001814	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
595495001815	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
595495001816	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
595495001817	Coenzyme A binding pocket [chemical binding]; other site
595495001818	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
595495001819	GIY-YIG motif/motif A; other site
595495001820	putative active site [active]
595495001821	putative metal binding site [ion binding]; other site
595495001822	hypothetical protein; Provisional; Region: PRK03467
595495001823	intracellular protease, PfpI family; Region: PfpI; TIGR01382
595495001824	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
595495001825	proposed catalytic triad [active]
595495001826	conserved cys residue [active]
595495001827	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
595495001828	NADH(P)-binding; Region: NAD_binding_10; pfam13460
595495001829	NAD binding site [chemical binding]; other site
595495001830	active site
595495001831	Predicted permease; Region: DUF318; pfam03773
595495001832	outer membrane lipoprotein; Provisional; Region: PRK11023
595495001833	BON domain; Region: BON; pfam04972
595495001834	BON domain; Region: BON; pfam04972
595495001835	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
595495001836	dimer interface [polypeptide binding]; other site
595495001837	active site
595495001838	TIGR00252 family protein; Region: TIGR00252
595495001839	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
595495001840	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
595495001841	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
595495001842	putative ligand binding site [chemical binding]; other site
595495001843	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
595495001844	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
595495001845	putative SAM binding site [chemical binding]; other site
595495001846	putative homodimer interface [polypeptide binding]; other site
595495001847	Fimbrial protein; Region: Fimbrial; pfam00419
595495001848	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
595495001849	PapC N-terminal domain; Region: PapC_N; pfam13954
595495001850	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
595495001851	PapC C-terminal domain; Region: PapC_C; pfam13953
595495001852	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
595495001853	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
595495001854	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
595495001855	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
595495001856	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
595495001857	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
595495001858	active site
595495001859	trimer interface [polypeptide binding]; other site
595495001860	allosteric site; other site
595495001861	active site lid [active]
595495001862	PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855
595495001863	PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757
595495001864	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
595495001865	active site
595495001866	phosphorylation site [posttranslational modification]
595495001867	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453
595495001868	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
595495001869	active site
595495001870	intersubunit interface [polypeptide binding]; other site
595495001871	zinc binding site [ion binding]; other site
595495001872	Na+ binding site [ion binding]; other site
595495001873	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
595495001874	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
595495001875	dimer interface [polypeptide binding]; other site
595495001876	active site
595495001877	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
595495001878	putative active site [active]
595495001879	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
595495001880	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
595495001881	active site
595495001882	dimer interface [polypeptide binding]; other site
595495001883	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
595495001884	active pocket/dimerization site; other site
595495001885	active site
595495001886	phosphorylation site [posttranslational modification]
595495001887	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
595495001888	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
595495001889	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
595495001890	active site
595495001891	phosphorylation site [posttranslational modification]
595495001892	tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458
595495001893	DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802
595495001894	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
595495001895	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
595495001896	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
595495001897	putative regulator PrlF; Provisional; Region: PRK09974
595495001898	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
595495001899	galactarate dehydratase; Region: galactar-dH20; TIGR03248
595495001900	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
595495001901	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
595495001902	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495001903	D-galactonate transporter; Region: 2A0114; TIGR00893
595495001904	putative substrate translocation pore; other site
595495001905	alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558
595495001906	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
595495001907	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
595495001908	glycerate kinase I; Provisional; Region: PRK10342
595495001909	hypothetical protein; Provisional; Region: PRK09716
595495001910	DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424
595495001911	DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341
595495001912	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495001913	The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418
595495001914	putative substrate binding pocket [chemical binding]; other site
595495001915	putative dimerization interface [polypeptide binding]; other site
595495001916	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
595495001917	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
595495001918	tetramer interface [polypeptide binding]; other site
595495001919	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495001920	catalytic residue [active]
595495001921	threonine/serine transporter TdcC; Provisional; Region: PRK13629
595495001922	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
595495001923	propionate/acetate kinase; Provisional; Region: PRK12379
595495001924	Acetokinase family; Region: Acetate_kinase; cl17229
595495001925	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
595495001926	Pyruvate formate lyase 1; Region: PFL1; cd01678
595495001927	coenzyme A binding site [chemical binding]; other site
595495001928	active site
595495001929	catalytic residues [active]
595495001930	glycine loop; other site
595495001931	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
595495001932	homotrimer interaction site [polypeptide binding]; other site
595495001933	putative active site [active]
595495001934	L-serine dehydratase TdcG; Provisional; Region: PRK15040
595495001935	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
595495001936	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
595495001937	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
595495001938	serine transporter; Region: stp; TIGR00814
595495001939	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
595495001940	Pirin-related protein [General function prediction only]; Region: COG1741
595495001941	Pirin; Region: Pirin; pfam02678
595495001942	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495001943	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
595495001944	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
595495001945	dimerization interface [polypeptide binding]; other site
595495001946	Protein of unknown function (DUF805); Region: DUF805; pfam05656
595495001947	Predicted membrane protein [Function unknown]; Region: COG3152
595495001948	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
595495001949	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
595495001950	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
595495001951	putative dimer interface [polypeptide binding]; other site
595495001952	N-terminal domain interface [polypeptide binding]; other site
595495001953	putative substrate binding pocket (H-site) [chemical binding]; other site
595495001954	Predicted membrane protein [Function unknown]; Region: COG2259
595495001955	YqjK-like protein; Region: YqjK; pfam13997
595495001956	Predicted membrane protein [Function unknown]; Region: COG5393
595495001957	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
595495001958	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
595495001959	EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629
595495001960	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
595495001961	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
595495001962	DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523
595495001963	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495001964	DNA-binding site [nucleotide binding]; DNA binding site
595495001965	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
595495001966	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
595495001967	putative fimbrial protein TcfA; Provisional; Region: PRK15308
595495001968	CS1 type fimbrial major subunit; Region: Fimbrial_CS1; pfam04449
595495001969	fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310
595495001970	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
595495001971	CblD like pilus biogenesis initiator; Region: CblD; cl06460
595495001972	D-galactonate transporter; Region: 2A0114; TIGR00893
595495001973	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495001974	putative substrate translocation pore; other site
595495001975	Glucuronate isomerase; Region: UxaC; pfam02614
595495001976	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
595495001977	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
595495001978	galactarate dehydratase; Region: galactar-dH20; TIGR03248
595495001979	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
595495001980	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
595495001981	serine/threonine transporter SstT; Provisional; Region: PRK13628
595495001982	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
595495001983	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
595495001984	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
595495001985	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
595495001986	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
595495001987	putative active site [active]
595495001988	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
595495001989	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
595495001990	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495001991	S-adenosylmethionine binding site [chemical binding]; other site
595495001992	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
595495001993	non-specific DNA binding site [nucleotide binding]; other site
595495001994	salt bridge; other site
595495001995	sequence-specific DNA binding site [nucleotide binding]; other site
595495001996	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
595495001997	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
595495001998	active site
595495001999	FMN binding site [chemical binding]; other site
595495002000	2,4-decadienoyl-CoA binding site; other site
595495002001	catalytic residue [active]
595495002002	4Fe-4S cluster binding site [ion binding]; other site
595495002003	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
595495002004	alpha-glucosidase; Provisional; Region: PRK10137
595495002005	Protein of unknown function, DUF608; Region: DUF608; pfam04685
595495002006	Trehalase; Region: Trehalase; cl17346
595495002007	inner membrane transporter YjeM; Provisional; Region: PRK15238
595495002008	cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202
595495002009	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
595495002010	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
595495002011	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
595495002012	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
595495002013	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
595495002014	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
595495002015	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
595495002016	DNA binding site [nucleotide binding]
595495002017	domain linker motif; other site
595495002018	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
595495002019	putative dimerization interface [polypeptide binding]; other site
595495002020	putative ligand binding site [chemical binding]; other site
595495002021	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
595495002022	dimer interface [polypeptide binding]; other site
595495002023	putative tRNA-binding site [nucleotide binding]; other site
595495002024	putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522
595495002025	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
595495002026	inhibitor-cofactor binding pocket; inhibition site
595495002027	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495002028	catalytic residue [active]
595495002029	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
595495002030	PAS fold; Region: PAS_3; pfam08447
595495002031	putative active site [active]
595495002032	heme pocket [chemical binding]; other site
595495002033	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
595495002034	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
595495002035	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
595495002036	dimer interface [polypeptide binding]; other site
595495002037	putative CheW interface [polypeptide binding]; other site
595495002038	Predicted transcriptional regulators [Transcription]; Region: COG1695
595495002039	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
595495002040	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
595495002041	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
595495002042	FAD binding pocket [chemical binding]; other site
595495002043	FAD binding motif [chemical binding]; other site
595495002044	phosphate binding motif [ion binding]; other site
595495002045	NAD binding pocket [chemical binding]; other site
595495002046	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
595495002047	active site
595495002048	SUMO-1 interface [polypeptide binding]; other site
595495002049	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
595495002050	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
595495002051	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
595495002052	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
595495002053	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
595495002054	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
595495002055	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
595495002056	DNA binding residues [nucleotide binding]
595495002057	DNA primase; Validated; Region: dnaG; PRK05667
595495002058	CHC2 zinc finger; Region: zf-CHC2; pfam01807
595495002059	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
595495002060	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
595495002061	active site
595495002062	metal binding site [ion binding]; metal-binding site
595495002063	interdomain interaction site; other site
595495002064	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
595495002065	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
595495002066	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
595495002067	UGMP family protein; Validated; Region: PRK09604
595495002068	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
595495002069	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
595495002070	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
595495002071	transmembrane helices; other site
595495002072	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
595495002073	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
595495002074	transcriptional activator TtdR; Provisional; Region: PRK09801
595495002075	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495002076	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
595495002077	putative effector binding pocket; other site
595495002078	putative dimerization interface [polypeptide binding]; other site
595495002079	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
595495002080	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
595495002081	homooctamer interface [polypeptide binding]; other site
595495002082	active site
595495002083	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
595495002084	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
595495002085	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
595495002086	active site
595495002087	NTP binding site [chemical binding]; other site
595495002088	metal binding triad [ion binding]; metal-binding site
595495002089	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
595495002090	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
595495002091	Zn2+ binding site [ion binding]; other site
595495002092	Mg2+ binding site [ion binding]; other site
595495002093	SH3 domain-containing protein; Provisional; Region: PRK10884
595495002094	Bacterial SH3 domain homologues; Region: SH3b; smart00287
595495002095	Uncharacterized conserved protein [Function unknown]; Region: COG3025
595495002096	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
595495002097	putative active site [active]
595495002098	putative metal binding residues [ion binding]; other site
595495002099	signature motif; other site
595495002100	putative triphosphate binding site [ion binding]; other site
595495002101	CHAD domain; Region: CHAD; pfam05235
595495002102	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
595495002103	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
595495002104	metal binding triad; other site
595495002105	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
595495002106	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
595495002107	metal binding triad; other site
595495002108	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
595495002109	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
595495002110	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
595495002111	putative ribose interaction site [chemical binding]; other site
595495002112	putative ADP binding site [chemical binding]; other site
595495002113	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
595495002114	active site
595495002115	nucleotide binding site [chemical binding]; other site
595495002116	HIGH motif; other site
595495002117	KMSKS motif; other site
595495002118	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
595495002119	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
595495002120	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
595495002121	glycogen synthesis protein GlgS; Provisional; Region: PRK02922
595495002122	Fimbrial protein; Region: Fimbrial; pfam00419
595495002123	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
595495002124	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
595495002125	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
595495002126	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
595495002127	PapC N-terminal domain; Region: PapC_N; pfam13954
595495002128	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
595495002129	PapC C-terminal domain; Region: PapC_C; pfam13953
595495002130	putative fimbrial protein; Provisional; Region: PRK09733
595495002131	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
595495002132	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
595495002133	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
595495002134	Protein of unknown function (DUF4051); Region: DUF4051; pfam13260
595495002135	zinc transporter ZupT; Provisional; Region: PRK04201
595495002136	ZIP Zinc transporter; Region: Zip; pfam02535
595495002137	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
595495002138	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
595495002139	putative active site [active]
595495002140	metal binding site [ion binding]; metal-binding site
595495002141	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
595495002142	hypothetical protein; Provisional; Region: PRK11653
595495002143	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
595495002144	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
595495002145	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
595495002146	dimer interface [polypeptide binding]; other site
595495002147	ADP-ribose binding site [chemical binding]; other site
595495002148	active site
595495002149	nudix motif; other site
595495002150	metal binding site [ion binding]; metal-binding site
595495002151	putative dehydrogenase; Provisional; Region: PRK11039
595495002152	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
595495002153	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
595495002154	active site
595495002155	metal binding site [ion binding]; metal-binding site
595495002156	hexamer interface [polypeptide binding]; other site
595495002157	esterase YqiA; Provisional; Region: PRK11071
595495002158	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
595495002159	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
595495002160	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495002161	ATP binding site [chemical binding]; other site
595495002162	Mg2+ binding site [ion binding]; other site
595495002163	G-X-G motif; other site
595495002164	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
595495002165	anchoring element; other site
595495002166	dimer interface [polypeptide binding]; other site
595495002167	ATP binding site [chemical binding]; other site
595495002168	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
595495002169	active site
595495002170	metal binding site [ion binding]; metal-binding site
595495002171	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
595495002172	Uncharacterized conserved protein [Function unknown]; Region: COG1359
595495002173	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
595495002174	sensor protein QseC; Provisional; Region: PRK10337
595495002175	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
595495002176	dimer interface [polypeptide binding]; other site
595495002177	phosphorylation site [posttranslational modification]
595495002178	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495002179	ATP binding site [chemical binding]; other site
595495002180	Mg2+ binding site [ion binding]; other site
595495002181	G-X-G motif; other site
595495002182	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
595495002183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495002184	active site
595495002185	phosphorylation site [posttranslational modification]
595495002186	intermolecular recognition site; other site
595495002187	dimerization interface [polypeptide binding]; other site
595495002188	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
595495002189	DNA binding site [nucleotide binding]
595495002190	TIGR00156 family protein; Region: TIGR00156
595495002191	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
595495002192	DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062
595495002193	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
595495002194	CAP-like domain; other site
595495002195	active site
595495002196	primary dimer interface [polypeptide binding]; other site
595495002197	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
595495002198	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
595495002199	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
595495002200	putative acyl-acceptor binding pocket; other site
595495002201	FtsI repressor; Provisional; Region: PRK10883
595495002202	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
595495002203	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
595495002204	hypothetical protein; Provisional; Region: PRK01254
595495002205	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
595495002206	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
595495002207	putative outer membrane lipoprotein; Provisional; Region: PRK09973
595495002208	Protein of unknown function (DUF3828); Region: DUF3828; pfam12883
595495002209	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
595495002210	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
595495002211	active site
595495002212	catalytic tetrad [active]
595495002213	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
595495002214	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
595495002215	dimer interface [polypeptide binding]; other site
595495002216	active site
595495002217	metal binding site [ion binding]; metal-binding site
595495002218	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
595495002219	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
595495002220	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495002221	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495002222	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
595495002223	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
595495002224	cystathionine beta-lyase; Provisional; Region: PRK08114
595495002225	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
595495002226	homodimer interface [polypeptide binding]; other site
595495002227	substrate-cofactor binding pocket; other site
595495002228	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495002229	catalytic residue [active]
595495002230	biopolymer transport protein ExbB; Provisional; Region: PRK10414
595495002231	biopolymer transport protein ExbD; Provisional; Region: PRK11267
595495002232	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
595495002233	oxidoreductase; Provisional; Region: PRK07985
595495002234	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
595495002235	NAD binding site [chemical binding]; other site
595495002236	metal binding site [ion binding]; metal-binding site
595495002237	active site
595495002238	hypothetical protein; Provisional; Region: PRK05208
595495002239	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
595495002240	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
595495002241	active site
595495002242	catalytic tetrad [active]
595495002243	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
595495002244	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
595495002245	Protein of unknown function (DUF2623); Region: DUF2623; pfam11115
595495002246	hydrogenase 2 small subunit; Provisional; Region: PRK10468
595495002247	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
595495002248	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
595495002249	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
595495002250	4Fe-4S binding domain; Region: Fer4_6; pfam12837
595495002251	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
595495002252	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
595495002253	hydrogenase 2 large subunit; Provisional; Region: PRK10467
595495002254	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
595495002255	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
595495002256	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
595495002257	putative substrate-binding site; other site
595495002258	nickel binding site [ion binding]; other site
595495002259	hydrogenase 2-specific chaperone; Provisional; Region: PRK10465
595495002260	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
595495002261	hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380
595495002262	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
595495002263	putative S-transferase; Provisional; Region: PRK11752
595495002264	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
595495002265	C-terminal domain interface [polypeptide binding]; other site
595495002266	GSH binding site (G-site) [chemical binding]; other site
595495002267	dimer interface [polypeptide binding]; other site
595495002268	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
595495002269	dimer interface [polypeptide binding]; other site
595495002270	N-terminal domain interface [polypeptide binding]; other site
595495002271	active site
595495002272	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
595495002273	CHAP domain; Region: CHAP; pfam05257
595495002274	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
595495002275	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
595495002276	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
595495002277	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
595495002278	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
595495002279	TMP-binding site; other site
595495002280	ATP-binding site [chemical binding]; other site
595495002281	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
595495002282	thymidylate kinase; Validated; Region: tmk; PRK00698
595495002283	TMP-binding site; other site
595495002284	ATP-binding site [chemical binding]; other site
595495002285	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
595495002286	Thymidylate kinase; Region: Thymidylate_kin; pfam02223
595495002287	active site
595495002288	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
595495002289	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
595495002290	Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695
595495002291	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
595495002292	Predicted permeases [General function prediction only]; Region: COG0795
595495002293	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
595495002294	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
595495002295	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
595495002296	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
595495002297	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
595495002298	catalytic residue [active]
595495002299	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
595495002300	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
595495002301	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
595495002302	NAD(P) binding site [chemical binding]; other site
595495002303	active site
595495002304	acyl-CoA synthetase; Validated; Region: PRK09192
595495002305	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
595495002306	acyl-activating enzyme (AAE) consensus motif; other site
595495002307	active site
595495002308	DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990
595495002309	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495002310	DNA-binding site [nucleotide binding]; DNA binding site
595495002311	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
595495002312	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
595495002313	FAD binding domain; Region: FAD_binding_4; pfam01565
595495002314	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
595495002315	FAD binding domain; Region: FAD_binding_4; pfam01565
595495002316	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
595495002317	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
595495002318	Cysteine-rich domain; Region: CCG; pfam02754
595495002319	Cysteine-rich domain; Region: CCG; pfam02754
595495002320	hypothetical protein; Provisional; Region: PRK09732
595495002321	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
595495002322	active site
595495002323	glycolate transporter; Provisional; Region: PRK09695
595495002324	L-lactate permease; Region: Lactate_perm; cl00701
595495002325	Domain of unknown function (DUF4092); Region: DUF4092; pfam13322
595495002326	Peptidase M60-like family; Region: M60-like; pfam13402
595495002327	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
595495002328	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
595495002329	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
595495002330	putative type II secretion protein GspC; Provisional; Region: PRK09681
595495002331	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
595495002332	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
595495002333	type II secretion system protein D; Region: type_II_gspD; TIGR02517
595495002334	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
595495002335	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
595495002336	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
595495002337	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
595495002338	type II secretion system protein E; Region: type_II_gspE; TIGR02533
595495002339	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
595495002340	Walker A motif; other site
595495002341	ATP binding site [chemical binding]; other site
595495002342	Walker B motif; other site
595495002343	type II secretion system protein F; Region: GspF; TIGR02120
595495002344	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
595495002345	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
595495002346	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
595495002347	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
595495002348	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
595495002349	Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963
595495002350	Type II transport protein GspH; Region: GspH; pfam12019
595495002351	type II secretion system protein I; Region: gspI; TIGR01707
595495002352	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
595495002353	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
595495002354	type II secretion system protein J; Region: gspJ; TIGR01711
595495002355	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
595495002356	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
595495002357	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
595495002358	GspL-like protein; Provisional; Region: PRK09662
595495002359	putative general secretion pathway protein YghD; Provisional; Region: PRK09731
595495002360	Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811
595495002361	ornithine decarboxylase; Provisional; Region: PRK13578
595495002362	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
595495002363	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
595495002364	homodimer interface [polypeptide binding]; other site
595495002365	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495002366	catalytic residue [active]
595495002367	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
595495002368	nucleoside transporter; Region: 2A0110; TIGR00889
595495002369	murein transglycosylase C; Provisional; Region: mltC; PRK11671
595495002370	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
595495002371	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
595495002372	N-acetyl-D-glucosamine binding site [chemical binding]; other site
595495002373	catalytic residue [active]
595495002374	oxidative damage protection protein; Provisional; Region: PRK05408
595495002375	adenine DNA glycosylase; Provisional; Region: PRK10880
595495002376	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
595495002377	minor groove reading motif; other site
595495002378	helix-hairpin-helix signature motif; other site
595495002379	substrate binding pocket [chemical binding]; other site
595495002380	active site
595495002381	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
595495002382	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
595495002383	DNA binding and oxoG recognition site [nucleotide binding]
595495002384	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
595495002385	hypothetical protein; Provisional; Region: PRK11702
595495002386	hypothetical protein; Provisional; Region: PRK10626
595495002387	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
595495002388	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
595495002389	homodimer interface [polypeptide binding]; other site
595495002390	active site
595495002391	Protein of unknown function (DUF1202); Region: DUF1202; pfam06717
595495002392	HemN family oxidoreductase; Provisional; Region: PRK05660
595495002393	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
595495002394	FeS/SAM binding site; other site
595495002395	HemN C-terminal domain; Region: HemN_C; pfam06969
595495002396	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
595495002397	active site
595495002398	dimerization interface [polypeptide binding]; other site
595495002399	hypothetical protein; Validated; Region: PRK05090
595495002400	YGGT family; Region: YGGT; pfam02325
595495002401	YGGT family; Region: YGGT; pfam02325
595495002402	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
595495002403	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
595495002404	catalytic residue [active]
595495002405	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
595495002406	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
595495002407	Walker A motif; other site
595495002408	ATP binding site [chemical binding]; other site
595495002409	Walker B motif; other site
595495002410	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
595495002411	hypothetical protein; Validated; Region: PRK00228
595495002412	glutathione synthetase; Provisional; Region: PRK05246
595495002413	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
595495002414	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
595495002415	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
595495002416	RNA methyltransferase, RsmE family; Region: TIGR00046
595495002417	DNA-specific endonuclease I; Provisional; Region: PRK15137
595495002418	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
595495002419	hypothetical protein; Provisional; Region: PRK04860
595495002420	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
595495002421	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
595495002422	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495002423	putative substrate translocation pore; other site
595495002424	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495002425	S-adenosylmethionine synthetase; Validated; Region: PRK05250
595495002426	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
595495002427	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
595495002428	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
595495002429	Protein of unknown function (DUF2684); Region: DUF2684; pfam10885
595495002430	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
595495002431	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
595495002432	dimer interface [polypeptide binding]; other site
595495002433	active site
595495002434	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
595495002435	catalytic residues [active]
595495002436	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
595495002437	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
595495002438	agmatinase; Region: agmatinase; TIGR01230
595495002439	oligomer interface [polypeptide binding]; other site
595495002440	putative active site [active]
595495002441	Mn binding site [ion binding]; other site
595495002442	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
595495002443	transketolase; Reviewed; Region: PRK12753
595495002444	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
595495002445	TPP-binding site [chemical binding]; other site
595495002446	dimer interface [polypeptide binding]; other site
595495002447	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
595495002448	PYR/PP interface [polypeptide binding]; other site
595495002449	dimer interface [polypeptide binding]; other site
595495002450	TPP binding site [chemical binding]; other site
595495002451	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
595495002452	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
595495002453	active site
595495002454	phosphorylation site [posttranslational modification]
595495002455	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
595495002456	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
595495002457	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
595495002458	active site
595495002459	P-loop; other site
595495002460	phosphorylation site [posttranslational modification]
595495002461	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
595495002462	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
595495002463	putative NAD(P) binding site [chemical binding]; other site
595495002464	catalytic Zn binding site [ion binding]; other site
595495002465	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
595495002466	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
595495002467	putative active site [active]
595495002468	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
595495002469	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022
595495002470	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
595495002471	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
595495002472	active site
595495002473	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
595495002474	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
595495002475	Walker A/P-loop; other site
595495002476	ATP binding site [chemical binding]; other site
595495002477	Q-loop/lid; other site
595495002478	ABC transporter signature motif; other site
595495002479	Walker B; other site
595495002480	D-loop; other site
595495002481	H-loop/switch region; other site
595495002482	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
595495002483	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
595495002484	Walker A/P-loop; other site
595495002485	ATP binding site [chemical binding]; other site
595495002486	Q-loop/lid; other site
595495002487	ABC transporter signature motif; other site
595495002488	Walker B; other site
595495002489	D-loop; other site
595495002490	H-loop/switch region; other site
595495002491	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
595495002492	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
595495002493	trimer interface [polypeptide binding]; other site
595495002494	putative Zn binding site [ion binding]; other site
595495002495	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
595495002496	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
595495002497	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
595495002498	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
595495002499	Phosphoglycerate kinase; Region: PGK; pfam00162
595495002500	substrate binding site [chemical binding]; other site
595495002501	hinge regions; other site
595495002502	ADP binding site [chemical binding]; other site
595495002503	catalytic site [active]
595495002504	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
595495002505	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
595495002506	active site
595495002507	intersubunit interface [polypeptide binding]; other site
595495002508	zinc binding site [ion binding]; other site
595495002509	Na+ binding site [ion binding]; other site
595495002510	mechanosensitive channel MscS; Provisional; Region: PRK10334
595495002511	Mechanosensitive ion channel; Region: MS_channel; pfam00924
595495002512	arginine exporter protein; Provisional; Region: PRK09304
595495002513	Uncharacterized conserved protein [Function unknown]; Region: COG2968
595495002514	oxidative stress defense protein; Provisional; Region: PRK11087
595495002515	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495002516	Transcriptional regulator [Transcription]; Region: LysR; COG0583
595495002517	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
595495002518	dimerization interface [polypeptide binding]; other site
595495002519	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
595495002520	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
595495002521	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
595495002522	methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423
595495002523	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
595495002524	substrate binding site [chemical binding]; other site
595495002525	oxyanion hole (OAH) forming residues; other site
595495002526	trimer interface [polypeptide binding]; other site
595495002527	membrane ATPase/protein kinase; Provisional; Region: PRK09435
595495002528	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
595495002529	Walker A; other site
595495002530	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
595495002531	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
595495002532	active site
595495002533	substrate binding site [chemical binding]; other site
595495002534	coenzyme B12 binding site [chemical binding]; other site
595495002535	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
595495002536	B12 binding site [chemical binding]; other site
595495002537	cobalt ligand [ion binding]; other site
595495002538	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
595495002539	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495002540	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
595495002541	putative dimerization interface [polypeptide binding]; other site
595495002542	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
595495002543	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
595495002544	tetramer (dimer of dimers) interface [polypeptide binding]; other site
595495002545	active site
595495002546	dimer interface [polypeptide binding]; other site
595495002547	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
595495002548	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
595495002549	ligand binding site [chemical binding]; other site
595495002550	NAD binding site [chemical binding]; other site
595495002551	tetramer interface [polypeptide binding]; other site
595495002552	catalytic site [active]
595495002553	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
595495002554	L-serine binding site [chemical binding]; other site
595495002555	ACT domain interface; other site
595495002556	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
595495002557	5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333
595495002558	Z-ring-associated protein; Provisional; Region: PRK10972
595495002559	hypothetical protein; Reviewed; Region: PRK01736
595495002560	proline aminopeptidase P II; Provisional; Region: PRK10879
595495002561	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
595495002562	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
595495002563	active site
595495002564	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
595495002565	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
595495002566	oxidoreductase; Provisional; Region: PRK08013
595495002567	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
595495002568	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
595495002569	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
595495002570	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
595495002571	lipoyl attachment site [posttranslational modification]; other site
595495002572	glycine dehydrogenase; Provisional; Region: PRK05367
595495002573	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
595495002574	tetramer interface [polypeptide binding]; other site
595495002575	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495002576	catalytic residue [active]
595495002577	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
595495002578	tetramer interface [polypeptide binding]; other site
595495002579	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495002580	catalytic residue [active]
595495002581	putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730
595495002582	classical (c) SDRs; Region: SDR_c; cd05233
595495002583	NAD(P) binding site [chemical binding]; other site
595495002584	active site
595495002585	6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014
595495002586	beta-galactosidase; Region: BGL; TIGR03356
595495002587	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
595495002588	hemolysin; Provisional; Region: PRK15087
595495002589	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
595495002590	putative global regulator; Reviewed; Region: PRK09559
595495002591	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
595495002592	hypothetical protein; Provisional; Region: PRK10878
595495002593	Protein of unknown function (DUF1434); Region: DUF1434; pfam07254
595495002594	flavodoxin FldB; Provisional; Region: PRK12359
595495002595	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
595495002596	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
595495002597	active site
595495002598	Int/Topo IB signature motif; other site
595495002599	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
595495002600	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
595495002601	dimerization domain [polypeptide binding]; other site
595495002602	dimer interface [polypeptide binding]; other site
595495002603	catalytic residues [active]
595495002604	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
595495002605	DHH family; Region: DHH; pfam01368
595495002606	DHHA1 domain; Region: DHHA1; pfam02272
595495002607	peptide chain release factor 2; Validated; Region: prfB; PRK00578
595495002608	This domain is found in peptide chain release factors; Region: PCRF; smart00937
595495002609	RF-1 domain; Region: RF-1; pfam00472
595495002610	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
595495002611	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
595495002612	dimer interface [polypeptide binding]; other site
595495002613	putative anticodon binding site; other site
595495002614	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
595495002615	motif 1; other site
595495002616	active site
595495002617	motif 2; other site
595495002618	motif 3; other site
595495002619	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
595495002620	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
595495002621	active site
595495002622	metal binding site [ion binding]; metal-binding site
595495002623	nudix motif; other site
595495002624	xanthine permease; Region: pbuX; TIGR03173
595495002625	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809
595495002626	4Fe-4S binding domain; Region: Fer4; pfam00037
595495002627	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
595495002628	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
595495002629	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
595495002630	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
595495002631	guanine deaminase; Provisional; Region: PRK09228
595495002632	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
595495002633	active site
595495002634	uracil-xanthine permease; Region: ncs2; TIGR00801
595495002635	putative hypoxanthine oxidase; Provisional; Region: PRK09800
595495002636	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
595495002637	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
595495002638	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
595495002639	probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312
595495002640	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
595495002641	putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314
595495002642	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
595495002643	active site
595495002644	putative substrate binding pocket [chemical binding]; other site
595495002645	putative selenate reductase subunit YgfK; Provisional; Region: PRK09853
595495002646	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
595495002647	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
595495002648	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
595495002649	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
595495002650	Ligand binding site; other site
595495002651	metal-binding site
595495002652	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
595495002653	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
595495002654	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
595495002655	XdhC Rossmann domain; Region: XdhC_C; pfam13478
595495002656	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
595495002657	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
595495002658	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
595495002659	carbamate kinase; Reviewed; Region: PRK12686
595495002660	putative substrate binding site [chemical binding]; other site
595495002661	homodimer interface [polypeptide binding]; other site
595495002662	nucleotide binding site [chemical binding]; other site
595495002663	nucleotide binding site [chemical binding]; other site
595495002664	D-hydantoinase; Region: D-hydantoinase; TIGR02033
595495002665	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
595495002666	tetramer interface [polypeptide binding]; other site
595495002667	active site
595495002668	peptidase; Reviewed; Region: PRK13004
595495002669	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649
595495002670	putative metal binding site [ion binding]; other site
595495002671	putative dimer interface [polypeptide binding]; other site
595495002672	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
595495002673	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
595495002674	catalytic residue [active]
595495002675	aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200
595495002676	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
595495002677	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
595495002678	GAF domain; Region: GAF; cl17456
595495002679	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
595495002680	PAS domain; Region: PAS; smart00091
595495002681	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495002682	Walker A motif; other site
595495002683	ATP binding site [chemical binding]; other site
595495002684	Walker B motif; other site
595495002685	arginine finger; other site
595495002686	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
595495002687	xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908
595495002688	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
595495002689	catalytic loop [active]
595495002690	iron binding site [ion binding]; other site
595495002691	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
595495002692	xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971
595495002693	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
595495002694	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
595495002695	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
595495002696	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
595495002697	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
595495002698	Peptidase family M23; Region: Peptidase_M23; pfam01551
595495002699	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
595495002700	type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796
595495002701	type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401
595495002702	type III secretion system protein SpaS; Validated; Region: PRK08156
595495002703	type III secretion system protein SpaS; Validated; Region: PRK08156
595495002704	InvH outer membrane lipoprotein; Region: InvH; pfam04741
595495002705	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
595495002706	DNA binding residues [nucleotide binding]
595495002707	type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363
595495002708	Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480
595495002709	invasion protein OrgB; Provisional; Region: PRK15322
595495002710	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
595495002711	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
595495002712	N-acetyl-D-glucosamine binding site [chemical binding]; other site
595495002713	catalytic residue [active]
595495002714	transcriptional regulator; Provisional; Region: PRK11906
595495002715	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
595495002716	DNA binding site [nucleotide binding]
595495002717	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
595495002718	Tetratricopeptide repeat; Region: TPR_3; pfam07720
595495002719	Tetratricopeptide repeat; Region: TPR_3; pfam07720
595495002720	hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264
595495002721	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
595495002722	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
595495002723	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
595495002724	DNA binding residues [nucleotide binding]
595495002725	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
595495002726	serine transporter; Region: stp; TIGR00814
595495002727	putative acyltransferase; Provisional; Region: PRK05790
595495002728	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
595495002729	dimer interface [polypeptide binding]; other site
595495002730	active site
595495002731	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
595495002732	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
595495002733	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
595495002734	NADP binding site [chemical binding]; other site
595495002735	homodimer interface [polypeptide binding]; other site
595495002736	active site
595495002737	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
595495002738	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495002739	putative substrate translocation pore; other site
595495002740	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495002741	putative racemase; Provisional; Region: PRK10200
595495002742	aspartate racemase; Region: asp_race; TIGR00035
595495002743	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
595495002744	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495002745	The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456
595495002746	putative dimerization interface [polypeptide binding]; other site
595495002747	diaminopimelate decarboxylase; Provisional; Region: PRK11165
595495002748	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
595495002749	active site
595495002750	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
595495002751	substrate binding site [chemical binding]; other site
595495002752	catalytic residues [active]
595495002753	dimer interface [polypeptide binding]; other site
595495002754	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
595495002755	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
595495002756	DNA binding site [nucleotide binding]
595495002757	domain linker motif; other site
595495002758	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
595495002759	dimerization interface (closed form) [polypeptide binding]; other site
595495002760	ligand binding site [chemical binding]; other site
595495002761	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
595495002762	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
595495002763	putative acyl-acceptor binding pocket; other site
595495002764	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
595495002765	acyl-activating enzyme (AAE) consensus motif; other site
595495002766	putative AMP binding site [chemical binding]; other site
595495002767	lysophospholipid transporter LplT; Provisional; Region: PRK11195
595495002768	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495002769	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
595495002770	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
595495002771	active site
595495002772	catalytic tetrad [active]
595495002773	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
595495002774	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
595495002775	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
595495002776	putative DNA-binding cleft [nucleotide binding]; other site
595495002777	putative DNA clevage site; other site
595495002778	molecular lever; other site
595495002779	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
595495002780	putative active site [active]
595495002781	Ap4A binding site [chemical binding]; other site
595495002782	nudix motif; other site
595495002783	putative metal binding site [ion binding]; other site
595495002784	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
595495002785	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
595495002786	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
595495002787	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
595495002788	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
595495002789	prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544
595495002790	thymidylate synthase; Reviewed; Region: thyA; PRK01827
595495002791	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
595495002792	dimerization interface [polypeptide binding]; other site
595495002793	active site
595495002794	hypothetical protein; Provisional; Region: PRK10506
595495002795	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
595495002796	hypothetical protein; Provisional; Region: PRK10557
595495002797	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
595495002798	hypothetical protein; Provisional; Region: PRK11521
595495002799	hypothetical protein; Provisional; Region: PRK10332
595495002800	Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528
595495002801	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
595495002802	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
595495002803	protease3; Provisional; Region: PRK15101
595495002804	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
595495002805	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
595495002806	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
595495002807	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
595495002808	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
595495002809	AAA domain; Region: AAA_30; pfam13604
595495002810	Family description; Region: UvrD_C_2; pfam13538
595495002811	N-acetylglutamate synthase; Validated; Region: PRK05279
595495002812	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
595495002813	putative feedback inhibition sensing region; other site
595495002814	putative nucleotide binding site [chemical binding]; other site
595495002815	putative substrate binding site [chemical binding]; other site
595495002816	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
595495002817	Coenzyme A binding pocket [chemical binding]; other site
595495002818	AMIN domain; Region: AMIN; pfam11741
595495002819	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
595495002820	active site
595495002821	metal binding site [ion binding]; metal-binding site
595495002822	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
595495002823	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
595495002824	ImpA domain protein; Region: DUF3702; pfam12486
595495002825	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
595495002826	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
595495002827	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
595495002828	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
595495002829	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
595495002830	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
595495002831	Transposase; Region: HTH_Tnp_1; cl17663
595495002832	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
595495002833	PAAR motif; Region: PAAR_motif; pfam05488
595495002834	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
595495002835	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
595495002836	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
595495002837	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
595495002838	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
595495002839	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
595495002840	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
595495002841	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
595495002842	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
595495002843	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
595495002844	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253
595495002845	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
595495002846	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
595495002847	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
595495002848	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
595495002849	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253
595495002850	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
595495002851	Clp amino terminal domain; Region: Clp_N; pfam02861
595495002852	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495002853	Walker A motif; other site
595495002854	ATP binding site [chemical binding]; other site
595495002855	Walker B motif; other site
595495002856	arginine finger; other site
595495002857	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495002858	Walker A motif; other site
595495002859	ATP binding site [chemical binding]; other site
595495002860	Walker B motif; other site
595495002861	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
595495002862	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
595495002863	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
595495002864	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
595495002865	ligand binding site [chemical binding]; other site
595495002866	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
595495002867	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
595495002868	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
595495002869	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
595495002870	Protein of unknown function (DUF877); Region: DUF877; pfam05943
595495002871	Protein of unknown function (DUF770); Region: DUF770; pfam05591
595495002872	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
595495002873	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
595495002874	putative ATP binding site [chemical binding]; other site
595495002875	putative substrate interface [chemical binding]; other site
595495002876	CsdA-binding activator; Provisional; Region: PRK15019
595495002877	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
595495002878	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
595495002879	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
595495002880	catalytic residue [active]
595495002881	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
595495002882	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
595495002883	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495002884	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
595495002885	dimerization interface [polypeptide binding]; other site
595495002886	substrate binding pocket [chemical binding]; other site
595495002887	hypothetical protein; Provisional; Region: PRK10873
595495002888	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
595495002889	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
595495002890	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
595495002891	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
595495002892	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
595495002893	L-fucose mutarotase; Provisional; Region: fucU; PRK15420
595495002894	L-fuculokinase; Provisional; Region: PRK10331
595495002895	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
595495002896	nucleotide binding site [chemical binding]; other site
595495002897	L-fucose isomerase; Provisional; Region: fucI; PRK10991
595495002898	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
595495002899	hexamer (dimer of trimers) interface [polypeptide binding]; other site
595495002900	trimer interface [polypeptide binding]; other site
595495002901	substrate binding site [chemical binding]; other site
595495002902	Mn binding site [ion binding]; other site
595495002903	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
595495002904	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495002905	putative substrate translocation pore; other site
595495002906	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
595495002907	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
595495002908	intersubunit interface [polypeptide binding]; other site
595495002909	active site
595495002910	Zn2+ binding site [ion binding]; other site
595495002911	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
595495002912	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
595495002913	dimer interface [polypeptide binding]; other site
595495002914	active site
595495002915	metal binding site [ion binding]; metal-binding site
595495002916	flap endonuclease-like protein; Provisional; Region: PRK09482
595495002917	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
595495002918	active site
595495002919	metal binding site 1 [ion binding]; metal-binding site
595495002920	putative 5' ssDNA interaction site; other site
595495002921	metal binding site 3; metal-binding site
595495002922	metal binding site 2 [ion binding]; metal-binding site
595495002923	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
595495002924	putative DNA binding site [nucleotide binding]; other site
595495002925	putative metal binding site [ion binding]; other site
595495002926	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
595495002927	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
595495002928	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
595495002929	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
595495002930	serine transporter; Region: stp; TIGR00814
595495002931	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
595495002932	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
595495002933	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
595495002934	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
595495002935	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
595495002936	SecY interacting protein Syd; Provisional; Region: PRK04968
595495002937	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098
595495002938	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
595495002939	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
595495002940	probable active site [active]
595495002941	flavodoxin; Provisional; Region: PRK08105
595495002942	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495002943	D-galactonate transporter; Region: 2A0114; TIGR00893
595495002944	putative substrate translocation pore; other site
595495002945	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
595495002946	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
595495002947	active site
595495002948	tetramer interface [polypeptide binding]; other site
595495002949	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
595495002950	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
595495002951	active site
595495002952	tetramer interface [polypeptide binding]; other site
595495002953	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
595495002954	TRAM domain; Region: TRAM; pfam01938
595495002955	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495002956	S-adenosylmethionine binding site [chemical binding]; other site
595495002957	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
595495002958	HD domain; Region: HD_4; pfam13328
595495002959	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
595495002960	synthetase active site [active]
595495002961	NTP binding site [chemical binding]; other site
595495002962	metal binding site [ion binding]; metal-binding site
595495002963	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
595495002964	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
595495002965	antitoxin MazE; Provisional; Region: PRK09798
595495002966	toxin MazF; Provisional; Region: PRK09907
595495002967	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
595495002968	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
595495002969	homodimer interface [polypeptide binding]; other site
595495002970	metal binding site [ion binding]; metal-binding site
595495002971	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
595495002972	homodimer interface [polypeptide binding]; other site
595495002973	active site
595495002974	putative chemical substrate binding site [chemical binding]; other site
595495002975	metal binding site [ion binding]; metal-binding site
595495002976	CTP synthetase; Validated; Region: pyrG; PRK05380
595495002977	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
595495002978	Catalytic site [active]
595495002979	active site
595495002980	UTP binding site [chemical binding]; other site
595495002981	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
595495002982	active site
595495002983	putative oxyanion hole; other site
595495002984	catalytic triad [active]
595495002985	enolase; Provisional; Region: eno; PRK00077
595495002986	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
595495002987	dimer interface [polypeptide binding]; other site
595495002988	metal binding site [ion binding]; metal-binding site
595495002989	substrate binding pocket [chemical binding]; other site
595495002990	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
595495002991	Repair protein; Region: Repair_PSII; pfam04536
595495002992	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
595495002993	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
595495002994	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
595495002995	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
595495002996	nucleotide binding site [chemical binding]; other site
595495002997	Major Facilitator Superfamily; Region: MFS_1; pfam07690
595495002998	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495002999	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
595495003000	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
595495003001	NADP binding site [chemical binding]; other site
595495003002	homodimer interface [polypeptide binding]; other site
595495003003	active site
595495003004	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
595495003005	FAD binding domain; Region: FAD_binding_4; pfam01565
595495003006	benzoate transport; Region: 2A0115; TIGR00895
595495003007	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495003008	putative substrate translocation pore; other site
595495003009	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
595495003010	Ligand binding site [chemical binding]; other site
595495003011	Electron transfer flavoprotein domain; Region: ETF; pfam01012
595495003012	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
595495003013	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
595495003014	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
595495003015	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
595495003016	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
595495003017	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
595495003018	putative oxidoreductase FixC; Provisional; Region: PRK10157
595495003019	6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470
595495003020	homohexamer interface [polypeptide binding]; other site
595495003021	putative substrate stabilizing pore; other site
595495003022	pterin binding site; other site
595495003023	sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953
595495003024	Flavodoxin; Region: Flavodoxin_1; pfam00258
595495003025	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
595495003026	FAD binding pocket [chemical binding]; other site
595495003027	FAD binding motif [chemical binding]; other site
595495003028	catalytic residues [active]
595495003029	NAD binding pocket [chemical binding]; other site
595495003030	phosphate binding motif [ion binding]; other site
595495003031	beta-alpha-beta structure motif; other site
595495003032	sulfite reductase subunit beta; Provisional; Region: PRK13504
595495003033	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
595495003034	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
595495003035	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
595495003036	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
595495003037	Active Sites [active]
595495003038	Hok/gef family; Region: HOK_GEF; pfam01848
595495003039	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
595495003040	CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203
595495003041	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
595495003042	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669
595495003043	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719
595495003044	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646
595495003045	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
595495003046	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
595495003047	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664
595495003048	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
595495003049	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648
595495003050	alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199
595495003051	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
595495003052	metal binding site [ion binding]; metal-binding site
595495003053	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
595495003054	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
595495003055	Active Sites [active]
595495003056	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
595495003057	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
595495003058	CysD dimerization site [polypeptide binding]; other site
595495003059	G1 box; other site
595495003060	putative GEF interaction site [polypeptide binding]; other site
595495003061	GTP/Mg2+ binding site [chemical binding]; other site
595495003062	Switch I region; other site
595495003063	G2 box; other site
595495003064	G3 box; other site
595495003065	Switch II region; other site
595495003066	G4 box; other site
595495003067	G5 box; other site
595495003068	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
595495003069	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
595495003070	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
595495003071	ligand-binding site [chemical binding]; other site
595495003072	Protein of unknown function (DUF3561); Region: DUF3561; pfam12084
595495003073	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
595495003074	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
595495003075	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
595495003076	substrate binding site; other site
595495003077	dimer interface; other site
595495003078	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
595495003079	homotrimer interaction site [polypeptide binding]; other site
595495003080	zinc binding site [ion binding]; other site
595495003081	CDP-binding sites; other site
595495003082	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
595495003083	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
595495003084	Permutation of conserved domain; other site
595495003085	active site
595495003086	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
595495003087	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
595495003088	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
595495003089	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495003090	S-adenosylmethionine binding site [chemical binding]; other site
595495003091	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
595495003092	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
595495003093	Peptidase family M23; Region: Peptidase_M23; pfam01551
595495003094	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
595495003095	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
595495003096	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
595495003097	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
595495003098	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
595495003099	DNA binding residues [nucleotide binding]
595495003100	MarR family; Region: MarR_2; cl17246
595495003101	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
595495003102	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
595495003103	Flavoprotein; Region: Flavoprotein; pfam02441
595495003104	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
595495003105	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
595495003106	putative transporter; Provisional; Region: PRK09821
595495003107	GntP family permease; Region: GntP_permease; pfam02447
595495003108	hypothetical protein; Provisional; Region: PRK09989
595495003109	putative aldolase; Validated; Region: PRK08130
595495003110	active site
595495003111	intersubunit interface [polypeptide binding]; other site
595495003112	Zn2+ binding site [ion binding]; other site
595495003113	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
595495003114	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
595495003115	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
595495003116	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
595495003117	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
595495003118	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
595495003119	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
595495003120	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
595495003121	active site
595495003122	metal binding site [ion binding]; metal-binding site
595495003123	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
595495003124	MutS domain I; Region: MutS_I; pfam01624
595495003125	MutS domain II; Region: MutS_II; pfam05188
595495003126	MutS domain III; Region: MutS_III; pfam05192
595495003127	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
595495003128	Walker A/P-loop; other site
595495003129	ATP binding site [chemical binding]; other site
595495003130	Q-loop/lid; other site
595495003131	ABC transporter signature motif; other site
595495003132	Walker B; other site
595495003133	D-loop; other site
595495003134	H-loop/switch region; other site
595495003135	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
595495003136	formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429
595495003137	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
595495003138	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
595495003139	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495003140	Walker A motif; other site
595495003141	ATP binding site [chemical binding]; other site
595495003142	Walker B motif; other site
595495003143	arginine finger; other site
595495003144	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
595495003145	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
595495003146	dimerization interface [polypeptide binding]; other site
595495003147	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
595495003148	ATP binding site [chemical binding]; other site
595495003149	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
595495003150	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
595495003151	hydrogenase assembly chaperone; Provisional; Region: PRK10409
595495003152	hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463
595495003153	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
595495003154	hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681
595495003155	formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198
595495003156	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
595495003157	formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042
595495003158	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
595495003159	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
595495003160	NADH dehydrogenase; Region: NADHdh; cl00469
595495003161	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
595495003162	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
595495003163	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
595495003164	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
595495003165	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
595495003166	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
595495003167	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
595495003168	Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067
595495003169	nickel binding site [ion binding]; other site
595495003170	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
595495003171	Transposase; Region: DEDD_Tnp_IS110; pfam01548
595495003172	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
595495003173	cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852
595495003174	beta-galactosidase; Region: BGL; TIGR03356
595495003175	PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796
595495003176	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
595495003177	active site turn [active]
595495003178	phosphorylation site [posttranslational modification]
595495003179	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
595495003180	Transcriptional regulators [Transcription]; Region: PurR; COG1609
595495003181	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
595495003182	DNA binding site [nucleotide binding]
595495003183	domain linker motif; other site
595495003184	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
595495003185	dimerization interface (closed form) [polypeptide binding]; other site
595495003186	ligand binding site [chemical binding]; other site
595495003187	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
595495003188	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
595495003189	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
595495003190	Acylphosphatase; Region: Acylphosphatase; pfam00708
595495003191	HypF finger; Region: zf-HYPF; pfam07503
595495003192	HypF finger; Region: zf-HYPF; pfam07503
595495003193	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
595495003194	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
595495003195	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
595495003196	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
595495003197	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
595495003198	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
595495003199	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
595495003200	iron binding site [ion binding]; other site
595495003201	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
595495003202	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
595495003203	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495003204	Walker A motif; other site
595495003205	ATP binding site [chemical binding]; other site
595495003206	Walker B motif; other site
595495003207	arginine finger; other site
595495003208	D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543
595495003209	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
595495003210	putative active site [active]
595495003211	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
595495003212	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
595495003213	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
595495003214	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
595495003215	DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234
595495003216	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
595495003217	Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322
595495003218	putative NAD(P) binding site [chemical binding]; other site
595495003219	active site
595495003220	PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377
595495003221	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
595495003222	PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825
595495003223	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
595495003224	PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821
595495003225	Transglycosylase SLT domain; Region: SLT_2; pfam13406
595495003226	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
595495003227	N-acetyl-D-glucosamine binding site [chemical binding]; other site
595495003228	hypothetical protein; Validated; Region: PRK03661
595495003229	recombinase A; Provisional; Region: recA; PRK09354
595495003230	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
595495003231	hexamer interface [polypeptide binding]; other site
595495003232	Walker A motif; other site
595495003233	ATP binding site [chemical binding]; other site
595495003234	Walker B motif; other site
595495003235	recombination regulator RecX; Reviewed; Region: recX; PRK00117
595495003236	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
595495003237	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
595495003238	motif 1; other site
595495003239	active site
595495003240	motif 2; other site
595495003241	motif 3; other site
595495003242	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
595495003243	DHHA1 domain; Region: DHHA1; pfam02272
595495003244	carbon storage regulator; Provisional; Region: PRK01712
595495003245	fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725
595495003246	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495003247	motif II; other site
595495003248	Predicted membrane protein [Function unknown]; Region: COG1238
595495003249	glutamate--cysteine ligase; Provisional; Region: PRK02107
595495003250	S-ribosylhomocysteinase; Provisional; Region: PRK02260
595495003251	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
595495003252	Zn2+ binding site [ion binding]; other site
595495003253	Mg2+ binding site [ion binding]; other site
595495003254	AAA domain; Region: AAA_33; pfam13671
595495003255	RNA ligase; Region: RNA_ligase; pfam09414
595495003256	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
595495003257	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495003258	putative substrate translocation pore; other site
595495003259	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495003260	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
595495003261	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
595495003262	HlyD family secretion protein; Region: HlyD_3; pfam13437
595495003263	transcriptional repressor MprA; Provisional; Region: PRK10870
595495003264	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
595495003265	putative L-valine exporter; Provisional; Region: PRK10408
595495003266	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
595495003267	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
595495003268	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495003269	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
595495003270	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
595495003271	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
595495003272	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495003273	dimer interface [polypeptide binding]; other site
595495003274	conserved gate region; other site
595495003275	putative PBP binding loops; other site
595495003276	ABC-ATPase subunit interface; other site
595495003277	glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070
595495003278	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
595495003279	Walker A/P-loop; other site
595495003280	ATP binding site [chemical binding]; other site
595495003281	Q-loop/lid; other site
595495003282	ABC transporter signature motif; other site
595495003283	Walker B; other site
595495003284	D-loop; other site
595495003285	H-loop/switch region; other site
595495003286	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
595495003287	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
595495003288	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
595495003289	dimer interface [polypeptide binding]; other site
595495003290	putative radical transfer pathway; other site
595495003291	diiron center [ion binding]; other site
595495003292	tyrosyl radical; other site
595495003293	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
595495003294	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
595495003295	Class I ribonucleotide reductase; Region: RNR_I; cd01679
595495003296	active site
595495003297	dimer interface [polypeptide binding]; other site
595495003298	catalytic residues [active]
595495003299	effector binding site; other site
595495003300	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
595495003301	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
595495003302	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
595495003303	catalytic residues [active]
595495003304	hypothetical protein; Provisional; Region: PRK10132
595495003305	hypothetical protein; Provisional; Region: PRK10556
595495003306	Protein of unknown function (DUF1144); Region: DUF1144; pfam06610
595495003307	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
595495003308	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
595495003309	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527
595495003310	active site residue [active]
595495003311	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
595495003312	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
595495003313	dimerization interface [polypeptide binding]; other site
595495003314	putative DNA binding site [nucleotide binding]; other site
595495003315	Transcriptional regulators [Transcription]; Region: MarR; COG1846
595495003316	putative Zn2+ binding site [ion binding]; other site
595495003317	Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401
595495003318	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
595495003319	bacterial OsmY and nodulation domain; Region: BON; smart00749
595495003320	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
595495003321	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
595495003322	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495003323	DNA-binding site [nucleotide binding]; DNA binding site
595495003324	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
595495003325	gamma-aminobutyrate transporter; Provisional; Region: PRK10197
595495003326	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
595495003327	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
595495003328	inhibitor-cofactor binding pocket; inhibition site
595495003329	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495003330	catalytic residue [active]
595495003331	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
595495003332	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
595495003333	tetramerization interface [polypeptide binding]; other site
595495003334	NAD(P) binding site [chemical binding]; other site
595495003335	catalytic residues [active]
595495003336	Predicted dehydrogenase [General function prediction only]; Region: COG0579
595495003337	hydroxyglutarate oxidase; Provisional; Region: PRK11728
595495003338	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
595495003339	substrate binding pocket [chemical binding]; other site
595495003340	active site
595495003341	iron coordination sites [ion binding]; other site
595495003342	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
595495003343	active site
595495003344	catalytic site [active]
595495003345	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
595495003346	Transposase; Region: HTH_Tnp_1; cl17663
595495003347	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
595495003348	putative transposase OrfB; Reviewed; Region: PHA02517
595495003349	HTH-like domain; Region: HTH_21; pfam13276
595495003350	Integrase core domain; Region: rve; pfam00665
595495003351	Integrase core domain; Region: rve_2; pfam13333
595495003352	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
595495003353	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495003354	ATP binding site [chemical binding]; other site
595495003355	Mg2+ binding site [ion binding]; other site
595495003356	G-X-G motif; other site
595495003357	integrase; Provisional; Region: PRK09692
595495003358	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
595495003359	active site
595495003360	Int/Topo IB signature motif; other site
595495003361	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
595495003362	SmpB-tmRNA interface; other site
595495003363	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
595495003364	putative coenzyme Q binding site [chemical binding]; other site
595495003365	hypothetical protein; Validated; Region: PRK01777
595495003366	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
595495003367	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
595495003368	recombination and repair protein; Provisional; Region: PRK10869
595495003369	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
595495003370	Walker A/P-loop; other site
595495003371	ATP binding site [chemical binding]; other site
595495003372	Q-loop/lid; other site
595495003373	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
595495003374	Q-loop/lid; other site
595495003375	ABC transporter signature motif; other site
595495003376	Walker B; other site
595495003377	D-loop; other site
595495003378	H-loop/switch region; other site
595495003379	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
595495003380	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
595495003381	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
595495003382	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
595495003383	dimer interface [polypeptide binding]; other site
595495003384	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
595495003385	hypothetical protein; Provisional; Region: PRK11573
595495003386	Domain of unknown function DUF21; Region: DUF21; pfam01595
595495003387	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
595495003388	Transporter associated domain; Region: CorC_HlyC; smart01091
595495003389	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
595495003390	signal recognition particle protein; Provisional; Region: PRK10867
595495003391	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
595495003392	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
595495003393	P loop; other site
595495003394	GTP binding site [chemical binding]; other site
595495003395	Signal peptide binding domain; Region: SRP_SPB; pfam02978
595495003396	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
595495003397	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
595495003398	RimM N-terminal domain; Region: RimM; pfam01782
595495003399	PRC-barrel domain; Region: PRC; pfam05239
595495003400	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
595495003401	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
595495003402	putative outer membrane lipoprotein; Provisional; Region: PRK09967
595495003403	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
595495003404	ligand binding site [chemical binding]; other site
595495003405	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
595495003406	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
595495003407	metal binding site [ion binding]; metal-binding site
595495003408	active site
595495003409	I-site; other site
595495003410	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
595495003411	lipoprotein; Provisional; Region: PRK11443
595495003412	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
595495003413	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
595495003414	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
595495003415	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
595495003416	chorismate mutase domain of T-protein; Region: CM_T; TIGR01799
595495003417	prephenate dehydrogenase; Validated; Region: PRK08507
595495003418	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
595495003419	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
595495003420	Prephenate dehydratase; Region: PDT; pfam00800
595495003421	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
595495003422	putative L-Phe binding site [chemical binding]; other site
595495003423	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
595495003424	30S subunit binding site; other site
595495003425	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
595495003426	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
595495003427	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
595495003428	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
595495003429	RNA binding surface [nucleotide binding]; other site
595495003430	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
595495003431	active site
595495003432	hypothetical protein; Provisional; Region: PRK10723
595495003433	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
595495003434	protein disaggregation chaperone; Provisional; Region: PRK10865
595495003435	Clp amino terminal domain; Region: Clp_N; pfam02861
595495003436	Clp amino terminal domain; Region: Clp_N; pfam02861
595495003437	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495003438	Walker A motif; other site
595495003439	ATP binding site [chemical binding]; other site
595495003440	Walker B motif; other site
595495003441	arginine finger; other site
595495003442	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495003443	Walker A motif; other site
595495003444	ATP binding site [chemical binding]; other site
595495003445	Walker B motif; other site
595495003446	arginine finger; other site
595495003447	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
595495003448	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
595495003449	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495003450	putative substrate translocation pore; other site
595495003451	lipoprotein; Provisional; Region: PRK10759
595495003452	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
595495003453	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
595495003454	domain interface [polypeptide binding]; other site
595495003455	putative active site [active]
595495003456	catalytic site [active]
595495003457	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
595495003458	domain interface [polypeptide binding]; other site
595495003459	putative active site [active]
595495003460	catalytic site [active]
595495003461	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
595495003462	CoA binding domain; Region: CoA_binding_2; pfam13380
595495003463	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
595495003464	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
595495003465	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
595495003466	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
595495003467	Uncharacterized conserved protein [Function unknown]; Region: COG3148
595495003468	thioredoxin 2; Provisional; Region: PRK10996
595495003469	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
595495003470	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
595495003471	catalytic residues [active]
595495003472	putative methyltransferase; Provisional; Region: PRK10864
595495003473	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
595495003474	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
595495003475	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
595495003476	ligand binding site [chemical binding]; other site
595495003477	active site
595495003478	UGI interface [polypeptide binding]; other site
595495003479	catalytic site [active]
595495003480	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
595495003481	cysteine/O-acetylserine exporter; Provisional; Region: PRK10323
595495003482	Transcriptional regulator [Transcription]; Region: LysR; COG0583
595495003483	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495003484	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
595495003485	dimerization interface [polypeptide binding]; other site
595495003486	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
595495003487	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
595495003488	ATP binding site [chemical binding]; other site
595495003489	Mg++ binding site [ion binding]; other site
595495003490	motif III; other site
595495003491	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
595495003492	nucleotide binding region [chemical binding]; other site
595495003493	ATP-binding site [chemical binding]; other site
595495003494	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
595495003495	Methyltransferase domain; Region: Methyltransf_26; pfam13659
595495003496	L-aspartate oxidase; Provisional; Region: PRK09077
595495003497	L-aspartate oxidase; Provisional; Region: PRK06175
595495003498	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
595495003499	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
595495003500	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
595495003501	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
595495003502	DNA binding residues [nucleotide binding]
595495003503	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
595495003504	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
595495003505	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
595495003506	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
595495003507	anti-sigma E factor; Provisional; Region: rseB; PRK09455
595495003508	SoxR reducing system protein RseC; Provisional; Region: PRK10862
595495003509	GTP-binding protein LepA; Provisional; Region: PRK05433
595495003510	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
595495003511	G1 box; other site
595495003512	putative GEF interaction site [polypeptide binding]; other site
595495003513	GTP/Mg2+ binding site [chemical binding]; other site
595495003514	Switch I region; other site
595495003515	G2 box; other site
595495003516	G3 box; other site
595495003517	Switch II region; other site
595495003518	G4 box; other site
595495003519	G5 box; other site
595495003520	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
595495003521	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
595495003522	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
595495003523	signal peptidase I; Provisional; Region: PRK10861
595495003524	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
595495003525	Catalytic site [active]
595495003526	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
595495003527	ribonuclease III; Reviewed; Region: rnc; PRK00102
595495003528	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
595495003529	dimerization interface [polypeptide binding]; other site
595495003530	active site
595495003531	metal binding site [ion binding]; metal-binding site
595495003532	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
595495003533	dsRNA binding site [nucleotide binding]; other site
595495003534	GTPase Era; Reviewed; Region: era; PRK00089
595495003535	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
595495003536	G1 box; other site
595495003537	GTP/Mg2+ binding site [chemical binding]; other site
595495003538	Switch I region; other site
595495003539	G2 box; other site
595495003540	Switch II region; other site
595495003541	G3 box; other site
595495003542	G4 box; other site
595495003543	G5 box; other site
595495003544	KH domain; Region: KH_2; pfam07650
595495003545	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
595495003546	Recombination protein O N terminal; Region: RecO_N; pfam11967
595495003547	Recombination protein O C terminal; Region: RecO_C; pfam02565
595495003548	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
595495003549	active site
595495003550	hydrophilic channel; other site
595495003551	dimerization interface [polypeptide binding]; other site
595495003552	catalytic residues [active]
595495003553	active site lid [active]
595495003554	holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516
595495003555	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
595495003556	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
595495003557	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
595495003558	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
595495003559	putative active site [active]
595495003560	hypothetical protein; Provisional; Region: PRK11590
595495003561	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
595495003562	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
595495003563	nucleoside/Zn binding site; other site
595495003564	dimer interface [polypeptide binding]; other site
595495003565	catalytic motif [active]
595495003566	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
595495003567	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
595495003568	substrate binding pocket [chemical binding]; other site
595495003569	membrane-bound complex binding site; other site
595495003570	hinge residues; other site
595495003571	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
595495003572	N-acetyl-D-glucosamine binding site [chemical binding]; other site
595495003573	catalytic residue [active]
595495003574	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
595495003575	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
595495003576	dimerization interface [polypeptide binding]; other site
595495003577	ATP binding site [chemical binding]; other site
595495003578	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
595495003579	dimerization interface [polypeptide binding]; other site
595495003580	ATP binding site [chemical binding]; other site
595495003581	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
595495003582	putative active site [active]
595495003583	catalytic triad [active]
595495003584	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
595495003585	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
595495003586	dimer interface [polypeptide binding]; other site
595495003587	phosphorylation site [posttranslational modification]
595495003588	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495003589	ATP binding site [chemical binding]; other site
595495003590	Mg2+ binding site [ion binding]; other site
595495003591	G-X-G motif; other site
595495003592	hypothetical protein; Provisional; Region: PRK10722
595495003593	response regulator GlrR; Provisional; Region: PRK15115
595495003594	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495003595	active site
595495003596	phosphorylation site [posttranslational modification]
595495003597	intermolecular recognition site; other site
595495003598	dimerization interface [polypeptide binding]; other site
595495003599	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495003600	Walker A motif; other site
595495003601	ATP binding site [chemical binding]; other site
595495003602	Walker B motif; other site
595495003603	arginine finger; other site
595495003604	nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858
595495003605	Nitrogen regulatory protein P-II; Region: P-II; smart00938
595495003606	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
595495003607	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
595495003608	heme-binding site [chemical binding]; other site
595495003609	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
595495003610	FAD binding pocket [chemical binding]; other site
595495003611	FAD binding motif [chemical binding]; other site
595495003612	phosphate binding motif [ion binding]; other site
595495003613	beta-alpha-beta structure motif; other site
595495003614	NAD binding pocket [chemical binding]; other site
595495003615	Heme binding  pocket [chemical binding]; other site
595495003616	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
595495003617	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
595495003618	dimer interface [polypeptide binding]; other site
595495003619	active site
595495003620	glycine-pyridoxal phosphate binding site [chemical binding]; other site
595495003621	folate binding site [chemical binding]; other site
595495003622	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
595495003623	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
595495003624	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
595495003625	nucleotide binding site [chemical binding]; other site
595495003626	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
595495003627	TPR motif; other site
595495003628	Tetratricopeptide repeat; Region: TPR_16; pfam13432
595495003629	binding surface
595495003630	TPR repeat; Region: TPR_11; pfam13414
595495003631	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
595495003632	TPR motif; other site
595495003633	binding surface
595495003634	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
595495003635	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
595495003636	ligand binding site [chemical binding]; other site
595495003637	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
595495003638	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
595495003639	Walker A/P-loop; other site
595495003640	ATP binding site [chemical binding]; other site
595495003641	Q-loop/lid; other site
595495003642	ABC transporter signature motif; other site
595495003643	Walker B; other site
595495003644	D-loop; other site
595495003645	H-loop/switch region; other site
595495003646	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
595495003647	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
595495003648	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
595495003649	TM-ABC transporter signature motif; other site
595495003650	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
595495003651	L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239
595495003652	putative NAD(P) binding site [chemical binding]; other site
595495003653	catalytic Zn binding site [ion binding]; other site
595495003654	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
595495003655	active site
595495003656	catalytic residues [active]
595495003657	Predicted membrane protein [Function unknown]; Region: COG2259
595495003658	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
595495003659	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
595495003660	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
595495003661	cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348
595495003662	NAD binding site [chemical binding]; other site
595495003663	active site
595495003664	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
595495003665	[2Fe-2S] cluster binding site [ion binding]; other site
595495003666	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
595495003667	inter-subunit interface; other site
595495003668	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
595495003669	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
595495003670	iron-sulfur cluster [ion binding]; other site
595495003671	[2Fe-2S] cluster binding site [ion binding]; other site
595495003672	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
595495003673	beta subunit interface [polypeptide binding]; other site
595495003674	alpha subunit interface [polypeptide binding]; other site
595495003675	active site
595495003676	substrate binding site [chemical binding]; other site
595495003677	Fe binding site [ion binding]; other site
595495003678	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
595495003679	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495003680	The C-terminal substrate binding domain of LysR-type transcriptional regulator HcaR in involved in 3-phenylpropionic acid catabolism, contains the type2 periplasmic binding fold; Region: PBP2_HcaR; cd08450
595495003681	putative dimerization interface [polypeptide binding]; other site
595495003682	putative substrate binding pocket [chemical binding]; other site
595495003683	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
595495003684	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495003685	putative substrate translocation pore; other site
595495003686	stationary phase inducible protein CsiE; Provisional; Region: PRK11564
595495003687	PRD domain; Region: PRD; pfam00874
595495003688	PRD domain; Region: PRD; pfam00874
595495003689	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
595495003690	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
595495003691	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
595495003692	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
595495003693	active site
595495003694	dimerization interface [polypeptide binding]; other site
595495003695	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
595495003696	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
595495003697	DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857
595495003698	Rrf2 family protein; Region: rrf2_super; TIGR00738
595495003699	cysteine desulfurase; Provisional; Region: PRK14012
595495003700	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
595495003701	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
595495003702	catalytic residue [active]
595495003703	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
595495003704	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
595495003705	trimerization site [polypeptide binding]; other site
595495003706	active site
595495003707	iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502
595495003708	co-chaperone HscB; Provisional; Region: hscB; PRK05014
595495003709	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
595495003710	HSP70 interaction site [polypeptide binding]; other site
595495003711	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
595495003712	chaperone protein HscA; Provisional; Region: hscA; PRK05183
595495003713	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
595495003714	nucleotide binding site [chemical binding]; other site
595495003715	putative NEF/HSP70 interaction site [polypeptide binding]; other site
595495003716	SBD interface [polypeptide binding]; other site
595495003717	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
595495003718	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
595495003719	catalytic loop [active]
595495003720	iron binding site [ion binding]; other site
595495003721	hypothetical protein; Provisional; Region: PRK10721
595495003722	aminopeptidase B; Provisional; Region: PRK05015
595495003723	Peptidase; Region: DUF3663; pfam12404
595495003724	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
595495003725	interface (dimer of trimers) [polypeptide binding]; other site
595495003726	Substrate-binding/catalytic site; other site
595495003727	Zn-binding sites [ion binding]; other site
595495003728	enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611
595495003729	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
595495003730	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
595495003731	active site residue [active]
595495003732	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
595495003733	active site residue [active]
595495003734	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
595495003735	MG2 domain; Region: A2M_N; pfam01835
595495003736	Alpha-2-macroglobulin family; Region: A2M; pfam00207
595495003737	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
595495003738	surface patch; other site
595495003739	thioester region; other site
595495003740	specificity defining residues; other site
595495003741	penicillin-binding protein 1C; Provisional; Region: PRK11240
595495003742	Transglycosylase; Region: Transgly; pfam00912
595495003743	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
595495003744	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
595495003745	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
595495003746	active site
595495003747	multimer interface [polypeptide binding]; other site
595495003748	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
595495003749	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
595495003750	FeS/SAM binding site; other site
595495003751	cytoskeletal protein RodZ; Provisional; Region: PRK10856
595495003752	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
595495003753	non-specific DNA binding site [nucleotide binding]; other site
595495003754	salt bridge; other site
595495003755	sequence-specific DNA binding site [nucleotide binding]; other site
595495003756	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
595495003757	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
595495003758	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
595495003759	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
595495003760	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
595495003761	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
595495003762	dimer interface [polypeptide binding]; other site
595495003763	motif 1; other site
595495003764	active site
595495003765	motif 2; other site
595495003766	motif 3; other site
595495003767	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
595495003768	anticodon binding site; other site
595495003769	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
595495003770	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
595495003771	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216
595495003772	Trp docking motif [polypeptide binding]; other site
595495003773	active site
595495003774	GTP-binding protein Der; Reviewed; Region: PRK00093
595495003775	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
595495003776	G1 box; other site
595495003777	GTP/Mg2+ binding site [chemical binding]; other site
595495003778	Switch I region; other site
595495003779	G2 box; other site
595495003780	Switch II region; other site
595495003781	G3 box; other site
595495003782	G4 box; other site
595495003783	G5 box; other site
595495003784	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
595495003785	G1 box; other site
595495003786	GTP/Mg2+ binding site [chemical binding]; other site
595495003787	Switch I region; other site
595495003788	G2 box; other site
595495003789	G3 box; other site
595495003790	Switch II region; other site
595495003791	G4 box; other site
595495003792	G5 box; other site
595495003793	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
595495003794	exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237
595495003795	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
595495003796	generic binding surface II; other site
595495003797	generic binding surface I; other site
595495003798	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
595495003799	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
595495003800	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
595495003801	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
595495003802	active site
595495003803	GMP synthase; Reviewed; Region: guaA; PRK00074
595495003804	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
595495003805	AMP/PPi binding site [chemical binding]; other site
595495003806	candidate oxyanion hole; other site
595495003807	catalytic triad [active]
595495003808	potential glutamine specificity residues [chemical binding]; other site
595495003809	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
595495003810	ATP Binding subdomain [chemical binding]; other site
595495003811	Ligand Binding sites [chemical binding]; other site
595495003812	Dimerization subdomain; other site
595495003813	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
595495003814	Protein of unknown function (DUF2633); Region: DUF2633; pfam11119
595495003815	MASE1; Region: MASE1; pfam05231
595495003816	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
595495003817	diguanylate cyclase; Region: GGDEF; smart00267
595495003818	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
595495003819	exopolyphosphatase; Provisional; Region: PRK10854
595495003820	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
595495003821	Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855
595495003822	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
595495003823	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
595495003824	Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114
595495003825	domain interface [polypeptide binding]; other site
595495003826	active site
595495003827	catalytic site [active]
595495003828	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
595495003829	putative active site [active]
595495003830	catalytic site [active]
595495003831	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
595495003832	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
595495003833	active site
595495003834	substrate binding site [chemical binding]; other site
595495003835	cosubstrate binding site; other site
595495003836	catalytic site [active]
595495003837	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
595495003838	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
595495003839	dimerization interface [polypeptide binding]; other site
595495003840	putative ATP binding site [chemical binding]; other site
595495003841	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
595495003842	active site
595495003843	uracil transporter; Provisional; Region: PRK10720
595495003844	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
595495003845	DNA replication initiation factor; Provisional; Region: PRK08084
595495003846	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
595495003847	ArsC family; Region: ArsC; pfam03960
595495003848	catalytic residues [active]
595495003849	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
595495003850	Peptidase family M48; Region: Peptidase_M48; cl12018
595495003851	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
595495003852	Domain of unknown function DUF20; Region: UPF0118; pfam01594
595495003853	putative formate transporter; Provisional; Region: focB; PRK09713
595495003854	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
595495003855	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
595495003856	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495003857	Walker A motif; other site
595495003858	ATP binding site [chemical binding]; other site
595495003859	Walker B motif; other site
595495003860	arginine finger; other site
595495003861	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
595495003862	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
595495003863	hydrogenase 4 subunit H; Validated; Region: PRK08222
595495003864	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
595495003865	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
595495003866	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
595495003867	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
595495003868	hydrogenase 4 subunit F; Validated; Region: PRK06458
595495003869	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
595495003870	hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492
595495003871	hydrogenase 4 subunit D; Validated; Region: PRK06525
595495003872	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
595495003873	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
595495003874	NADH dehydrogenase; Region: NADHdh; cl00469
595495003875	hydrogenase 4 subunit B; Validated; Region: PRK06521
595495003876	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
595495003877	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
595495003878	4Fe-4S binding domain; Region: Fer4; pfam00037
595495003879	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
595495003880	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
595495003881	catalytic triad [active]
595495003882	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
595495003883	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
595495003884	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
595495003885	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
595495003886	dihydrodipicolinate synthase; Region: dapA; TIGR00674
595495003887	dimer interface [polypeptide binding]; other site
595495003888	active site
595495003889	catalytic residue [active]
595495003890	lipoprotein; Provisional; Region: PRK11679
595495003891	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
595495003892	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
595495003893	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
595495003894	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
595495003895	ATP binding site [chemical binding]; other site
595495003896	active site
595495003897	substrate binding site [chemical binding]; other site
595495003898	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
595495003899	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
595495003900	oligomeric interface; other site
595495003901	putative active site [active]
595495003902	homodimer interface [polypeptide binding]; other site
595495003903	Predicted metalloprotease [General function prediction only]; Region: COG2321
595495003904	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
595495003905	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
595495003906	Helicase; Region: Helicase_RecD; pfam05127
595495003907	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
595495003908	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
595495003909	putative hydrolase; Provisional; Region: PRK11460
595495003910	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
595495003911	hypothetical protein; Provisional; Region: PRK13664
595495003912	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
595495003913	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
595495003914	metal binding site [ion binding]; metal-binding site
595495003915	dimer interface [polypeptide binding]; other site
595495003916	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
595495003917	ArsC family; Region: ArsC; pfam03960
595495003918	putative catalytic residues [active]
595495003919	aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555
595495003920	Protein export membrane protein; Region: SecD_SecF; cl14618
595495003921	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
595495003922	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
595495003923	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
595495003924	dimerization interface [polypeptide binding]; other site
595495003925	Histidine kinase; Region: HisKA_3; pfam07730
595495003926	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495003927	ATP binding site [chemical binding]; other site
595495003928	Mg2+ binding site [ion binding]; other site
595495003929	G-X-G motif; other site
595495003930	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769
595495003931	4Fe-4S binding domain; Region: Fer4; pfam00037
595495003932	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
595495003933	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
595495003934	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
595495003935	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
595495003936	dimer interface [polypeptide binding]; other site
595495003937	ADP-ribose binding site [chemical binding]; other site
595495003938	active site
595495003939	nudix motif; other site
595495003940	metal binding site [ion binding]; metal-binding site
595495003941	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
595495003942	transketolase; Reviewed; Region: PRK12753
595495003943	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
595495003944	TPP-binding site [chemical binding]; other site
595495003945	dimer interface [polypeptide binding]; other site
595495003946	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
595495003947	PYR/PP interface [polypeptide binding]; other site
595495003948	dimer interface [polypeptide binding]; other site
595495003949	TPP binding site [chemical binding]; other site
595495003950	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
595495003951	transaldolase-like protein; Provisional; Region: PTZ00411
595495003952	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
595495003953	active site
595495003954	dimer interface [polypeptide binding]; other site
595495003955	catalytic residue [active]
595495003956	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
595495003957	Malic enzyme, N-terminal domain; Region: malic; pfam00390
595495003958	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
595495003959	putative NAD(P) binding site [chemical binding]; other site
595495003960	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
595495003961	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
595495003962	putative hexamer interface [polypeptide binding]; other site
595495003963	putative hexagonal pore; other site
595495003964	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
595495003965	G1 box; other site
595495003966	GTP/Mg2+ binding site [chemical binding]; other site
595495003967	G2 box; other site
595495003968	Switch I region; other site
595495003969	G3 box; other site
595495003970	Switch II region; other site
595495003971	G4 box; other site
595495003972	G5 box; other site
595495003973	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
595495003974	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766
595495003975	ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020
595495003976	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
595495003977	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
595495003978	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
595495003979	Hexamer interface [polypeptide binding]; other site
595495003980	Hexagonal pore residue; other site
595495003981	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
595495003982	Hexamer/Pentamer interface [polypeptide binding]; other site
595495003983	central pore; other site
595495003984	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
595495003985	putative catalytic cysteine [active]
595495003986	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
595495003987	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
595495003988	nucleotide binding site [chemical binding]; other site
595495003989	ethanol dehydrogenase EutG; Provisional; Region: PRK15454
595495003990	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
595495003991	active site
595495003992	metal binding site [ion binding]; metal-binding site
595495003993	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192
595495003994	reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719
595495003995	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
595495003996	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
595495003997	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
595495003998	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
595495003999	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
595495004000	putative hexamer interface [polypeptide binding]; other site
595495004001	putative hexagonal pore; other site
595495004002	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
595495004003	putative hexamer interface [polypeptide binding]; other site
595495004004	putative hexagonal pore; other site
595495004005	carboxysome structural protein EutK; Provisional; Region: PRK15466
595495004006	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
595495004007	Hexamer interface [polypeptide binding]; other site
595495004008	Hexagonal pore residue; other site
595495004009	transcriptional regulator EutR; Provisional; Region: PRK10130
595495004010	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495004011	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495004012	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
595495004013	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
595495004014	N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319
595495004015	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
595495004016	active site
595495004017	metal binding site [ion binding]; metal-binding site
595495004018	putative acetyltransferase; Provisional; Region: PRK03624
595495004019	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
595495004020	Coenzyme A binding pocket [chemical binding]; other site
595495004021	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
595495004022	RpoE-regulated lipoprotein; Provisional; Region: PRK10718
595495004023	Protein of unknown function (DUF1131); Region: DUF1131; pfam06572
595495004024	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
595495004025	putative periplasmic esterase; Provisional; Region: PRK03642
595495004026	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
595495004027	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
595495004028	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
595495004029	active site turn [active]
595495004030	phosphorylation site [posttranslational modification]
595495004031	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
595495004032	N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274
595495004033	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
595495004034	putative active site [active]
595495004035	transcriptional regulator MurR; Provisional; Region: PRK15482
595495004036	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
595495004037	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
595495004038	putative active site [active]
595495004039	short chain dehydrogenase; Provisional; Region: PRK08226
595495004040	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
595495004041	NAD binding site [chemical binding]; other site
595495004042	homotetramer interface [polypeptide binding]; other site
595495004043	homodimer interface [polypeptide binding]; other site
595495004044	active site
595495004045	thiosulfate transporter subunit; Provisional; Region: PRK10852
595495004046	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
595495004047	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
595495004048	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495004049	dimer interface [polypeptide binding]; other site
595495004050	conserved gate region; other site
595495004051	putative PBP binding loops; other site
595495004052	ABC-ATPase subunit interface; other site
595495004053	sulfate transport protein; Provisional; Region: cysT; CHL00187
595495004054	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495004055	dimer interface [polypeptide binding]; other site
595495004056	conserved gate region; other site
595495004057	putative PBP binding loops; other site
595495004058	ABC-ATPase subunit interface; other site
595495004059	sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851
595495004060	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
595495004061	Walker A/P-loop; other site
595495004062	ATP binding site [chemical binding]; other site
595495004063	Q-loop/lid; other site
595495004064	ABC transporter signature motif; other site
595495004065	Walker B; other site
595495004066	D-loop; other site
595495004067	H-loop/switch region; other site
595495004068	TOBE-like domain; Region: TOBE_3; pfam12857
595495004069	cysteine synthase B; Region: cysM; TIGR01138
595495004070	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
595495004071	dimer interface [polypeptide binding]; other site
595495004072	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495004073	catalytic residue [active]
595495004074	hypothetical protein; Provisional; Region: PRK10318
595495004075	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
595495004076	dimer interface [polypeptide binding]; other site
595495004077	pyridoxamine kinase; Validated; Region: PRK05756
595495004078	pyridoxal binding site [chemical binding]; other site
595495004079	ATP binding site [chemical binding]; other site
595495004080	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
595495004081	HPr interaction site; other site
595495004082	glycerol kinase (GK) interaction site [polypeptide binding]; other site
595495004083	active site
595495004084	phosphorylation site [posttranslational modification]
595495004085	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
595495004086	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
595495004087	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
595495004088	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
595495004089	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
595495004090	dimerization domain swap beta strand [polypeptide binding]; other site
595495004091	regulatory protein interface [polypeptide binding]; other site
595495004092	active site
595495004093	regulatory phosphorylation site [posttranslational modification]; other site
595495004094	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
595495004095	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
595495004096	dimer interface [polypeptide binding]; other site
595495004097	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495004098	catalytic residue [active]
595495004099	putative sulfate transport protein CysZ; Validated; Region: PRK04949
595495004100	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
595495004101	cell division protein ZipA; Provisional; Region: PRK03427
595495004102	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
595495004103	FtsZ protein binding site [polypeptide binding]; other site
595495004104	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
595495004105	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
595495004106	nucleotide binding pocket [chemical binding]; other site
595495004107	K-X-D-G motif; other site
595495004108	catalytic site [active]
595495004109	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
595495004110	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
595495004111	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
595495004112	Dimer interface [polypeptide binding]; other site
595495004113	BRCT sequence motif; other site
595495004114	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530
595495004115	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
595495004116	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
595495004117	Transcriptional regulator [Transcription]; Region: LysR; COG0583
595495004118	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495004119	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
595495004120	putative dimerization interface [polypeptide binding]; other site
595495004121	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
595495004122	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
595495004123	active site
595495004124	HIGH motif; other site
595495004125	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
595495004126	active site
595495004127	KMSKS motif; other site
595495004128	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
595495004129	salt bridge; other site
595495004130	non-specific DNA binding site [nucleotide binding]; other site
595495004131	sequence-specific DNA binding site [nucleotide binding]; other site
595495004132	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
595495004133	MASE1; Region: MASE1; pfam05231
595495004134	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
595495004135	diguanylate cyclase; Region: GGDEF; smart00267
595495004136	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
595495004137	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
595495004138	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
595495004139	Nucleoside recognition; Region: Gate; pfam07670
595495004140	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
595495004141	manganese transport protein MntH; Reviewed; Region: PRK00701
595495004142	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
595495004143	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
595495004144	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
595495004145	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
595495004146	Cl- selectivity filter; other site
595495004147	Cl- binding residues [ion binding]; other site
595495004148	pore gating glutamate residue; other site
595495004149	dimer interface [polypeptide binding]; other site
595495004150	glucokinase, proteobacterial type; Region: glk; TIGR00749
595495004151	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
595495004152	nucleotide binding site [chemical binding]; other site
595495004153	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
595495004154	active site
595495004155	P-loop; other site
595495004156	phosphorylation site [posttranslational modification]
595495004157	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
595495004158	aminopeptidase; Provisional; Region: PRK09795
595495004159	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
595495004160	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
595495004161	active site
595495004162	exoaminopeptidase; Provisional; Region: PRK09961
595495004163	M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638
595495004164	oligomer interface [polypeptide binding]; other site
595495004165	active site
595495004166	metal binding site [ion binding]; metal-binding site
595495004167	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
595495004168	dimerization domain swap beta strand [polypeptide binding]; other site
595495004169	regulatory protein interface [polypeptide binding]; other site
595495004170	active site
595495004171	regulatory phosphorylation site [posttranslational modification]; other site
595495004172	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
595495004173	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
595495004174	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
595495004175	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
595495004176	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
595495004177	active site
595495004178	phosphorylation site [posttranslational modification]
595495004179	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
595495004180	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495004181	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
595495004182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495004183	active site
595495004184	phosphorylation site [posttranslational modification]
595495004185	intermolecular recognition site; other site
595495004186	dimerization interface [polypeptide binding]; other site
595495004187	LytTr DNA-binding domain; Region: LytTR; pfam04397
595495004188	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
595495004189	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
595495004190	GAF domain; Region: GAF; pfam01590
595495004191	Histidine kinase; Region: His_kinase; pfam06580
595495004192	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495004193	ATP binding site [chemical binding]; other site
595495004194	Mg2+ binding site [ion binding]; other site
595495004195	G-X-G motif; other site
595495004196	aminotransferase; Validated; Region: PRK08175
595495004197	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
595495004198	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495004199	homodimer interface [polypeptide binding]; other site
595495004200	catalytic residue [active]
595495004201	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
595495004202	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
595495004203	putative acyl-acceptor binding pocket; other site
595495004204	Protein of unknown function (DUF2545); Region: DUF2545; pfam10810
595495004205	hypothetical protein; Provisional; Region: PRK10316
595495004206	YfdX protein; Region: YfdX; pfam10938
595495004207	formyl-coenzyme A transferase; Provisional; Region: PRK05398
595495004208	CoA-transferase family III; Region: CoA_transf_3; pfam02515
595495004209	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
595495004210	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
595495004211	PYR/PP interface [polypeptide binding]; other site
595495004212	dimer interface [polypeptide binding]; other site
595495004213	TPP binding site [chemical binding]; other site
595495004214	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
595495004215	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
595495004216	TPP-binding site; other site
595495004217	dimer interface [polypeptide binding]; other site
595495004218	putative transporter YfdV; Provisional; Region: PRK09903
595495004219	putative CoA-transferase; Provisional; Region: PRK11430
595495004220	CoA-transferase family III; Region: CoA_transf_3; pfam02515
595495004221	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
595495004222	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
595495004223	substrate binding pocket [chemical binding]; other site
595495004224	membrane-bound complex binding site; other site
595495004225	hinge residues; other site
595495004226	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
595495004227	substrate binding pocket [chemical binding]; other site
595495004228	membrane-bound complex binding site; other site
595495004229	hinge residues; other site
595495004230	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
595495004231	dimer interface [polypeptide binding]; other site
595495004232	phosphorylation site [posttranslational modification]
595495004233	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495004234	ATP binding site [chemical binding]; other site
595495004235	Mg2+ binding site [ion binding]; other site
595495004236	G-X-G motif; other site
595495004237	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495004238	active site
595495004239	phosphorylation site [posttranslational modification]
595495004240	intermolecular recognition site; other site
595495004241	dimerization interface [polypeptide binding]; other site
595495004242	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
595495004243	putative binding surface; other site
595495004244	active site
595495004245	DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958
595495004246	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495004247	active site
595495004248	phosphorylation site [posttranslational modification]
595495004249	intermolecular recognition site; other site
595495004250	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
595495004251	DNA binding residues [nucleotide binding]
595495004252	dimerization interface [polypeptide binding]; other site
595495004253	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
595495004254	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
595495004255	HlyD family secretion protein; Region: HlyD_3; pfam13437
595495004256	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
595495004257	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495004258	putative substrate translocation pore; other site
595495004259	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495004260	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
595495004261	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
595495004262	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
595495004263	catalytic residue [active]
595495004264	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
595495004265	DNA binding site [nucleotide binding]
595495004266	domain linker motif; other site
595495004267	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
595495004268	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
595495004269	putative dimerization interface [polypeptide binding]; other site
595495004270	putative ligand binding site [chemical binding]; other site
595495004271	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
595495004272	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
595495004273	substrate binding [chemical binding]; other site
595495004274	active site
595495004275	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
595495004276	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
595495004277	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
595495004278	putative substrate binding site [chemical binding]; other site
595495004279	putative ATP binding site [chemical binding]; other site
595495004280	LacY proton/sugar symporter; Region: LacY_symp; pfam01306
595495004281	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495004282	putative substrate translocation pore; other site
595495004283	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
595495004284	The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain; Region: ASCH; smart01022
595495004285	Protein of unknown function (DUF551); Region: DUF551; pfam04448
595495004286	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
595495004287	Protein of unknown function (DUF2737); Region: DUF2737; pfam10930
595495004288	Protein of unknown function (DUF2856); Region: DUF2856; pfam11043
595495004289	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
595495004290	active site
595495004291	catalytic site [active]
595495004292	substrate binding site [chemical binding]; other site
595495004293	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
595495004294	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
595495004295	dimer interface [polypeptide binding]; other site
595495004296	ssDNA binding site [nucleotide binding]; other site
595495004297	tetramer (dimer of dimers) interface [polypeptide binding]; other site
595495004298	Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936
595495004299	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
595495004300	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
595495004301	non-specific DNA binding site [nucleotide binding]; other site
595495004302	salt bridge; other site
595495004303	sequence-specific DNA binding site [nucleotide binding]; other site
595495004304	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
595495004305	Catalytic site [active]
595495004306	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
595495004307	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
595495004308	non-specific DNA binding site [nucleotide binding]; other site
595495004309	salt bridge; other site
595495004310	sequence-specific DNA binding site [nucleotide binding]; other site
595495004311	Bacteriophage CII protein; Region: Phage_CII; pfam05269
595495004312	Protein of unknown function (DUF2740); Region: DUF2740; pfam10872
595495004313	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
595495004314	phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600
595495004315	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
595495004316	Walker A motif; other site
595495004317	ATP binding site [chemical binding]; other site
595495004318	Walker B motif; other site
595495004319	NinB protein; Region: NinB; pfam05772
595495004320	phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712
595495004321	NINE Protein; Region: NinE; pfam05322
595495004322	Protein of unknown function (DUF2591); Region: DUF2591; pfam10765
595495004323	NinF protein; Region: NinF; pfam05810
595495004324	Protein of unknown function (DUF1364); Region: DUF1364; pfam07102
595495004325	Endodeoxyribonuclease RusA; Region: RusA; cl01885
595495004326	Phage NinH protein; Region: Phage_NinH; pfam06322
595495004327	Antitermination protein; Region: Antiterm; pfam03589
595495004328	Antitermination protein; Region: Antiterm; pfam03589
595495004329	phage holin, lambda family; Region: holin_lambda; TIGR01594
595495004330	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
595495004331	N-acetyl-D-glucosamine binding site [chemical binding]; other site
595495004332	catalytic residue [active]
595495004333	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
595495004334	T5orf172 domain; Region: T5orf172; pfam10544
595495004335	Protein of unknown function (DUF2560); Region: DUF2560; pfam10834
595495004336	Terminase-like family; Region: Terminase_6; pfam03237
595495004337	Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565
595495004338	Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306
595495004339	coat protein; Region: PHA01511
595495004340	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
595495004341	P22 tail accessory factor; Region: P22_Tail-4; pfam11650
595495004342	Phage stabilisation protein; Region: Phage_stabilise; pfam11134
595495004343	Vitamin-D-receptor interacting Mediator subunit 4; Region: Med4; pfam10018
595495004344	Protein of unknown function (DUF2824); Region: DUF2824; pfam11039
595495004345	Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; Region: DM14; smart00685
595495004346	Mnt; Region: mnt; PHA01513
595495004347	Arc-like DNA binding domain; Region: Arc; pfam03869
595495004348	Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423
595495004349	Head binding; Region: Head_binding; pfam09008
595495004350	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
595495004351	integrase; Provisional; Region: PRK09692
595495004352	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
595495004353	active site
595495004354	Int/Topo IB signature motif; other site
595495004355	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
595495004356	ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091
595495004357	long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716
595495004358	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691
595495004359	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
595495004360	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
595495004361	dimer interface [polypeptide binding]; other site
595495004362	active site
595495004363	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
595495004364	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
595495004365	substrate binding site [chemical binding]; other site
595495004366	oxyanion hole (OAH) forming residues; other site
595495004367	trimer interface [polypeptide binding]; other site
595495004368	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
595495004369	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
595495004370	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
595495004371	catalytic core [active]
595495004372	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
595495004373	putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284
595495004374	PapC N-terminal domain; Region: PapC_N; pfam13954
595495004375	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
595495004376	PapC C-terminal domain; Region: PapC_C; pfam13953
595495004377	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
595495004378	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
595495004379	Fimbrial protein; Region: Fimbrial; cl01416
595495004380	Fimbrial protein; Region: Fimbrial; cl01416
595495004381	Fimbrial protein; Region: Fimbrial; cl01416
595495004382	Protein of unknown function (DUF2544); Region: DUF2544; pfam11245
595495004383	hypothetical protein; Provisional; Region: PRK04946
595495004384	Smr domain; Region: Smr; pfam01713
595495004385	HemK family putative methylases; Region: hemK_fam; TIGR00536
595495004386	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495004387	S-adenosylmethionine binding site [chemical binding]; other site
595495004388	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
595495004389	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
595495004390	Tetramer interface [polypeptide binding]; other site
595495004391	active site
595495004392	FMN-binding site [chemical binding]; other site
595495004393	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
595495004394	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
595495004395	hypothetical protein; Provisional; Region: PRK10621
595495004396	Predicted permeases [General function prediction only]; Region: COG0730
595495004397	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101
595495004398	YfcL protein; Region: YfcL; pfam08891
595495004399	Uncharacterized conserved protein [Function unknown]; Region: COG4121
595495004400	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
595495004401	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
595495004402	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
595495004403	dimer interface [polypeptide binding]; other site
595495004404	active site
595495004405	putative transporter; Provisional; Region: PRK12382
595495004406	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495004407	putative substrate translocation pore; other site
595495004408	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
595495004409	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
595495004410	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
595495004411	ligand binding site [chemical binding]; other site
595495004412	NAD binding site [chemical binding]; other site
595495004413	catalytic site [active]
595495004414	homodimer interface [polypeptide binding]; other site
595495004415	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
595495004416	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
595495004417	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
595495004418	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
595495004419	dimerization interface 3.5A [polypeptide binding]; other site
595495004420	active site
595495004421	hypothetical protein; Provisional; Region: PRK10847
595495004422	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
595495004423	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
595495004424	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
595495004425	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
595495004426	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
595495004427	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
595495004428	cell division protein DedD; Provisional; Region: PRK11633
595495004429	Sporulation related domain; Region: SPOR; pfam05036
595495004430	colicin V production protein; Provisional; Region: PRK10845
595495004431	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
595495004432	amidophosphoribosyltransferase; Provisional; Region: PRK09246
595495004433	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
595495004434	active site
595495004435	tetramer interface [polypeptide binding]; other site
595495004436	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
595495004437	active site
595495004438	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
595495004439	Flavoprotein; Region: Flavoprotein; pfam02441
595495004440	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
595495004441	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
595495004442	substrate binding pocket [chemical binding]; other site
595495004443	membrane-bound complex binding site; other site
595495004444	hinge residues; other site
595495004445	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
595495004446	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
595495004447	substrate binding pocket [chemical binding]; other site
595495004448	membrane-bound complex binding site; other site
595495004449	hinge residues; other site
595495004450	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
595495004451	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495004452	dimer interface [polypeptide binding]; other site
595495004453	conserved gate region; other site
595495004454	putative PBP binding loops; other site
595495004455	ABC-ATPase subunit interface; other site
595495004456	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495004457	dimer interface [polypeptide binding]; other site
595495004458	conserved gate region; other site
595495004459	putative PBP binding loops; other site
595495004460	ABC-ATPase subunit interface; other site
595495004461	histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619
595495004462	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
595495004463	Walker A/P-loop; other site
595495004464	ATP binding site [chemical binding]; other site
595495004465	Q-loop/lid; other site
595495004466	ABC transporter signature motif; other site
595495004467	Walker B; other site
595495004468	D-loop; other site
595495004469	H-loop/switch region; other site
595495004470	putative transposase; Provisional; Region: PRK09857
595495004471	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
595495004472	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
595495004473	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
595495004474	putative NAD(P) binding site [chemical binding]; other site
595495004475	putative active site [active]
595495004476	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
595495004477	homooctamer interface [polypeptide binding]; other site
595495004478	active site
595495004479	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
595495004480	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
595495004481	C-terminal domain interface [polypeptide binding]; other site
595495004482	GSH binding site (G-site) [chemical binding]; other site
595495004483	dimer interface [polypeptide binding]; other site
595495004484	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
595495004485	N-terminal domain interface [polypeptide binding]; other site
595495004486	putative dimer interface [polypeptide binding]; other site
595495004487	active site
595495004488	glutathione S-transferase; Provisional; Region: PRK15113
595495004489	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
595495004490	C-terminal domain interface [polypeptide binding]; other site
595495004491	GSH binding site (G-site) [chemical binding]; other site
595495004492	dimer interface [polypeptide binding]; other site
595495004493	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
595495004494	N-terminal domain interface [polypeptide binding]; other site
595495004495	putative dimer interface [polypeptide binding]; other site
595495004496	putative substrate binding pocket (H-site) [chemical binding]; other site
595495004497	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
595495004498	active site
595495004499	metal binding site [ion binding]; metal-binding site
595495004500	homotetramer interface [polypeptide binding]; other site
595495004501	NUDIX hydrolase YfcD; Provisional; Region: PRK15393
595495004502	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697
595495004503	nudix motif; other site
595495004504	hypothetical protein; Provisional; Region: PRK11588
595495004505	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
595495004506	phosphate acetyltransferase; Reviewed; Region: PRK05632
595495004507	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
595495004508	DRTGG domain; Region: DRTGG; pfam07085
595495004509	phosphate acetyltransferase; Region: pta; TIGR00651
595495004510	propionate/acetate kinase; Provisional; Region: PRK12379
595495004511	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
595495004512	hypothetical protein; Provisional; Region: PRK01816
595495004513	hypothetical protein; Validated; Region: PRK05445
595495004514	putative phosphatase; Provisional; Region: PRK11587
595495004515	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495004516	motif II; other site
595495004517	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
595495004518	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
595495004519	TrkA-C domain; Region: TrkA_C; pfam02080
595495004520	TrkA-C domain; Region: TrkA_C; pfam02080
595495004521	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
595495004522	5'-nucleotidase; Provisional; Region: PRK03826
595495004523	aminotransferase AlaT; Validated; Region: PRK09265
595495004524	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
595495004525	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495004526	homodimer interface [polypeptide binding]; other site
595495004527	catalytic residue [active]
595495004528	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
595495004529	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495004530	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
595495004531	putative dimerization interface [polypeptide binding]; other site
595495004532	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
595495004533	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
595495004534	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
595495004535	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
595495004536	NADH dehydrogenase subunit D; Validated; Region: PRK06075
595495004537	NADH dehydrogenase subunit E; Validated; Region: PRK07539
595495004538	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
595495004539	putative dimer interface [polypeptide binding]; other site
595495004540	[2Fe-2S] cluster binding site [ion binding]; other site
595495004541	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
595495004542	SLBB domain; Region: SLBB; pfam10531
595495004543	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
595495004544	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
595495004545	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
595495004546	catalytic loop [active]
595495004547	iron binding site [ion binding]; other site
595495004548	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
595495004549	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
595495004550	[4Fe-4S] binding site [ion binding]; other site
595495004551	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
595495004552	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
595495004553	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
595495004554	4Fe-4S binding domain; Region: Fer4; pfam00037
595495004555	4Fe-4S binding domain; Region: Fer4; pfam00037
595495004556	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
595495004557	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
595495004558	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
595495004559	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
595495004560	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
595495004561	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
595495004562	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
595495004563	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
595495004564	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
595495004565	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
595495004566	deubiquitinase; Provisional; Region: PRK11836
595495004567	ribonuclease BN; Region: true_RNase_BN; TIGR02649
595495004568	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
595495004569	Coenzyme A binding pocket [chemical binding]; other site
595495004570	hypothetical protein; Provisional; Region: PRK10404
595495004571	menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012
595495004572	isochorismate synthases; Region: isochor_syn; TIGR00543
595495004573	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
595495004574	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
595495004575	dimer interface [polypeptide binding]; other site
595495004576	tetramer interface [polypeptide binding]; other site
595495004577	PYR/PP interface [polypeptide binding]; other site
595495004578	TPP binding site [chemical binding]; other site
595495004579	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
595495004580	TPP-binding site; other site
595495004581	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
595495004582	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
595495004583	nucleophilic elbow; other site
595495004584	catalytic triad; other site
595495004585	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
595495004586	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
595495004587	substrate binding site [chemical binding]; other site
595495004588	oxyanion hole (OAH) forming residues; other site
595495004589	trimer interface [polypeptide binding]; other site
595495004590	O-succinylbenzoate synthase; Provisional; Region: PRK05105
595495004591	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
595495004592	active site
595495004593	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
595495004594	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
595495004595	acyl-activating enzyme (AAE) consensus motif; other site
595495004596	putative AMP binding site [chemical binding]; other site
595495004597	putative active site [active]
595495004598	putative CoA binding site [chemical binding]; other site
595495004599	signal transduction protein PmrD; Provisional; Region: PRK15450
595495004600	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
595495004601	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
595495004602	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
595495004603	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
595495004604	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
595495004605	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
595495004606	putative active site [active]
595495004607	putative catalytic site [active]
595495004608	putative Zn binding site [ion binding]; other site
595495004609	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
595495004610	ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644
595495004611	substrate binding site [chemical binding]; other site
595495004612	cosubstrate binding site; other site
595495004613	catalytic site [active]
595495004614	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
595495004615	active site
595495004616	hexamer interface [polypeptide binding]; other site
595495004617	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
595495004618	NAD binding site [chemical binding]; other site
595495004619	substrate binding site [chemical binding]; other site
595495004620	active site
595495004621	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
595495004622	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
595495004623	Ligand binding site; other site
595495004624	Putative Catalytic site; other site
595495004625	DXD motif; other site
595495004626	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
595495004627	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
595495004628	inhibitor-cofactor binding pocket; inhibition site
595495004629	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495004630	catalytic residue [active]
595495004631	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
595495004632	catalytic core [active]
595495004633	nucleoside triphosphatase NudI; Provisional; Region: PRK15472
595495004634	YfaZ precursor; Region: YfaZ; pfam07437
595495004635	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
595495004636	hypothetical protein; Provisional; Region: PRK03673
595495004637	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
595495004638	putative MPT binding site; other site
595495004639	Competence-damaged protein; Region: CinA; cl00666
595495004640	hypothetical protein; Provisional; Region: PRK09956
595495004641	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
595495004642	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
595495004643	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
595495004644	Cysteine-rich domain; Region: CCG; pfam02754
595495004645	Cysteine-rich domain; Region: CCG; pfam02754
595495004646	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075
595495004647	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
595495004648	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
595495004649	hydroxyglutarate oxidase; Provisional; Region: PRK11728
595495004650	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
595495004651	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
595495004652	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495004653	putative substrate translocation pore; other site
595495004654	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
595495004655	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
595495004656	active site
595495004657	catalytic site [active]
595495004658	metal binding site [ion binding]; metal-binding site
595495004659	hypothetical protein; Provisional; Region: PRK09902
595495004660	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
595495004661	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
595495004662	catalytic loop [active]
595495004663	iron binding site [ion binding]; other site
595495004664	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
595495004665	dimer interface [polypeptide binding]; other site
595495004666	putative radical transfer pathway; other site
595495004667	diiron center [ion binding]; other site
595495004668	tyrosyl radical; other site
595495004669	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
595495004670	ATP cone domain; Region: ATP-cone; pfam03477
595495004671	Class I ribonucleotide reductase; Region: RNR_I; cd01679
595495004672	active site
595495004673	dimer interface [polypeptide binding]; other site
595495004674	catalytic residues [active]
595495004675	effector binding site; other site
595495004676	R2 peptide binding site; other site
595495004677	adhesin; Provisional; Region: PRK09752
595495004678	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
595495004679	Autotransporter beta-domain; Region: Autotransporter; pfam03797
595495004680	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
595495004681	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495004682	S-adenosylmethionine binding site [chemical binding]; other site
595495004683	DNA gyrase subunit A; Validated; Region: PRK05560
595495004684	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
595495004685	CAP-like domain; other site
595495004686	active site
595495004687	primary dimer interface [polypeptide binding]; other site
595495004688	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
595495004689	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
595495004690	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
595495004691	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
595495004692	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
595495004693	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
595495004694	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685
595495004695	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234
595495004696	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
595495004697	MG2 domain; Region: A2M_N; pfam01835
595495004698	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
595495004699	Alpha-2-macroglobulin family; Region: A2M; pfam00207
595495004700	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
595495004701	Predicted secreted protein [Function unknown]; Region: COG5445
595495004702	Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062
595495004703	Predicted secreted protein [Function unknown]; Region: COG5445
595495004704	Stage II sporulation protein; Region: SpoIID; pfam08486
595495004705	Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062
595495004706	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
595495004707	Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906
595495004708	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
595495004709	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
595495004710	dimer interface [polypeptide binding]; other site
595495004711	phosphorylation site [posttranslational modification]
595495004712	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495004713	ATP binding site [chemical binding]; other site
595495004714	Mg2+ binding site [ion binding]; other site
595495004715	G-X-G motif; other site
595495004716	RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456
595495004717	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495004718	active site
595495004719	phosphorylation site [posttranslational modification]
595495004720	intermolecular recognition site; other site
595495004721	dimerization interface [polypeptide binding]; other site
595495004722	transcriptional regulator RcsB; Provisional; Region: PRK10840
595495004723	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495004724	active site
595495004725	phosphorylation site [posttranslational modification]
595495004726	intermolecular recognition site; other site
595495004727	dimerization interface [polypeptide binding]; other site
595495004728	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
595495004729	DNA binding residues [nucleotide binding]
595495004730	dimerization interface [polypeptide binding]; other site
595495004731	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
595495004732	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495004733	ATP binding site [chemical binding]; other site
595495004734	G-X-G motif; other site
595495004735	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
595495004736	putative binding surface; other site
595495004737	active site
595495004738	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
595495004739	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
595495004740	trimer interface [polypeptide binding]; other site
595495004741	eyelet of channel; other site
595495004742	thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461
595495004743	ApbE family; Region: ApbE; pfam02424
595495004744	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
595495004745	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
595495004746	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495004747	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495004748	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
595495004749	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
595495004750	DNA binding site [nucleotide binding]
595495004751	active site
595495004752	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
595495004753	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
595495004754	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
595495004755	Walker A/P-loop; other site
595495004756	ATP binding site [chemical binding]; other site
595495004757	Q-loop/lid; other site
595495004758	ABC transporter signature motif; other site
595495004759	Walker B; other site
595495004760	D-loop; other site
595495004761	H-loop/switch region; other site
595495004762	malate:quinone oxidoreductase; Validated; Region: PRK05257
595495004763	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
595495004764	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242
595495004765	secondary substrate binding site; other site
595495004766	primary substrate binding site; other site
595495004767	inhibition loop; other site
595495004768	dimerization interface [polypeptide binding]; other site
595495004769	tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750
595495004770	ferredoxin-type protein; Provisional; Region: PRK10194
595495004771	assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553
595495004772	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
595495004773	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
595495004774	[4Fe-4S] binding site [ion binding]; other site
595495004775	molybdopterin cofactor binding site; other site
595495004776	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
595495004777	molybdopterin cofactor binding site; other site
595495004778	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
595495004779	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
595495004780	4Fe-4S binding domain; Region: Fer4_5; pfam12801
595495004781	4Fe-4S binding domain; Region: Fer4_6; pfam12837
595495004782	nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586
595495004783	cytochrome c-type protein NapC; Provisional; Region: PRK10617
595495004784	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
595495004785	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
595495004786	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
595495004787	Walker A/P-loop; other site
595495004788	ATP binding site [chemical binding]; other site
595495004789	Q-loop/lid; other site
595495004790	ABC transporter signature motif; other site
595495004791	Walker B; other site
595495004792	D-loop; other site
595495004793	H-loop/switch region; other site
595495004794	heme exporter protein CcmB; Region: ccmB; TIGR01190
595495004795	heme exporter protein CcmC; Region: ccmC; TIGR01191
595495004796	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
595495004797	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
595495004798	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
595495004799	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
595495004800	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
595495004801	catalytic residues [active]
595495004802	central insert; other site
595495004803	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
595495004804	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
595495004805	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
595495004806	binding surface
595495004807	TPR motif; other site
595495004808	transcriptional regulator NarP; Provisional; Region: PRK10403
595495004809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495004810	active site
595495004811	phosphorylation site [posttranslational modification]
595495004812	intermolecular recognition site; other site
595495004813	dimerization interface [polypeptide binding]; other site
595495004814	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
595495004815	DNA binding residues [nucleotide binding]
595495004816	dimerization interface [polypeptide binding]; other site
595495004817	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
595495004818	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
595495004819	Sulfatase; Region: Sulfatase; pfam00884
595495004820	hypothetical protein; Provisional; Region: PRK13689
595495004821	Nucleoid-associated protein [General function prediction only]; Region: COG3081
595495004822	nucleoid-associated protein NdpA; Validated; Region: PRK00378
595495004823	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
595495004824	5S rRNA interface [nucleotide binding]; other site
595495004825	CTC domain interface [polypeptide binding]; other site
595495004826	L16 interface [polypeptide binding]; other site
595495004827	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
595495004828	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
595495004829	ATP binding site [chemical binding]; other site
595495004830	putative Mg++ binding site [ion binding]; other site
595495004831	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
595495004832	nucleotide binding region [chemical binding]; other site
595495004833	ATP-binding site [chemical binding]; other site
595495004834	Ribosomal L40e family; Region: Ribosomal_L40e; cl00671
595495004835	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
595495004836	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
595495004837	RNA binding surface [nucleotide binding]; other site
595495004838	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
595495004839	active site
595495004840	uracil binding [chemical binding]; other site
595495004841	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495004842	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
595495004843	putative substrate translocation pore; other site
595495004844	hypothetical protein; Provisional; Region: PRK11835
595495004845	microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134
595495004846	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
595495004847	Walker A/P-loop; other site
595495004848	ATP binding site [chemical binding]; other site
595495004849	Q-loop/lid; other site
595495004850	ABC transporter signature motif; other site
595495004851	Walker B; other site
595495004852	D-loop; other site
595495004853	H-loop/switch region; other site
595495004854	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
595495004855	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
595495004856	Walker A/P-loop; other site
595495004857	ATP binding site [chemical binding]; other site
595495004858	Q-loop/lid; other site
595495004859	ABC transporter signature motif; other site
595495004860	Walker B; other site
595495004861	D-loop; other site
595495004862	H-loop/switch region; other site
595495004863	microcin C ABC transporter permease; Provisional; Region: PRK15021
595495004864	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495004865	dimer interface [polypeptide binding]; other site
595495004866	conserved gate region; other site
595495004867	ABC-ATPase subunit interface; other site
595495004868	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
595495004869	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495004870	dimer interface [polypeptide binding]; other site
595495004871	conserved gate region; other site
595495004872	putative PBP binding loops; other site
595495004873	ABC-ATPase subunit interface; other site
595495004874	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
595495004875	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
595495004876	phage resistance protein; Provisional; Region: PRK10551
595495004877	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
595495004878	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
595495004879	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
595495004880	NlpC/P60 family; Region: NLPC_P60; pfam00877
595495004881	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
595495004882	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
595495004883	active site
595495004884	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
595495004885	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
595495004886	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
595495004887	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
595495004888	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
595495004889	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
595495004890	elongation factor P; Provisional; Region: PRK04542
595495004891	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
595495004892	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
595495004893	RNA binding site [nucleotide binding]; other site
595495004894	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
595495004895	RNA binding site [nucleotide binding]; other site
595495004896	Flagellin N-methylase; Region: FliB; pfam03692
595495004897	sugar efflux transporter B; Provisional; Region: PRK15011
595495004898	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495004899	putative substrate translocation pore; other site
595495004900	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
595495004901	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
595495004902	active site
595495004903	phosphorylation site [posttranslational modification]
595495004904	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
595495004905	dimerization domain swap beta strand [polypeptide binding]; other site
595495004906	regulatory protein interface [polypeptide binding]; other site
595495004907	active site
595495004908	regulatory phosphorylation site [posttranslational modification]; other site
595495004909	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
595495004910	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
595495004911	putative substrate binding site [chemical binding]; other site
595495004912	putative ATP binding site [chemical binding]; other site
595495004913	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
595495004914	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
595495004915	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
595495004916	active site
595495004917	P-loop; other site
595495004918	phosphorylation site [posttranslational modification]
595495004919	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
595495004920	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
595495004921	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
595495004922	substrate binding site [chemical binding]; other site
595495004923	ATP binding site [chemical binding]; other site
595495004924	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
595495004925	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
595495004926	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
595495004927	Nucleoside recognition; Region: Gate; pfam07670
595495004928	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
595495004929	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
595495004930	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
595495004931	ligand binding site [chemical binding]; other site
595495004932	flexible hinge region; other site
595495004933	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
595495004934	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
595495004935	active site
595495004936	tetramer interface [polypeptide binding]; other site
595495004937	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
595495004938	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
595495004939	Nucleoside recognition; Region: Gate; pfam07670
595495004940	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
595495004941	putative kinase; Provisional; Region: PRK09954
595495004942	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
595495004943	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
595495004944	substrate binding site [chemical binding]; other site
595495004945	ATP binding site [chemical binding]; other site
595495004946	endonuclease IV; Provisional; Region: PRK01060
595495004947	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
595495004948	AP (apurinic/apyrimidinic) site pocket; other site
595495004949	DNA interaction; other site
595495004950	Metal-binding active site; metal-binding site
595495004951	conserved hypothetical integral membrane protein; Region: TIGR00698
595495004952	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
595495004953	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495004954	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
595495004955	putative dimerization interface [polypeptide binding]; other site
595495004956	lysine transporter; Provisional; Region: PRK10836
595495004957	catecholate siderophore receptor CirA; Provisional; Region: PRK10064
595495004958	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
595495004959	N-terminal plug; other site
595495004960	ligand-binding site [chemical binding]; other site
595495004961	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
595495004962	S-formylglutathione hydrolase; Region: PLN02442
595495004963	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
595495004964	homodecamer interface [polypeptide binding]; other site
595495004965	GTP cyclohydrolase I; Provisional; Region: PLN03044
595495004966	active site
595495004967	putative catalytic site residues [active]
595495004968	zinc binding site [ion binding]; other site
595495004969	GTP-CH-I/GFRP interaction surface; other site
595495004970	Predicted membrane protein [Function unknown]; Region: COG2311
595495004971	hypothetical protein; Provisional; Region: PRK10835
595495004972	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
595495004973	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
595495004974	DNA binding site [nucleotide binding]
595495004975	domain linker motif; other site
595495004976	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
595495004977	dimerization interface (closed form) [polypeptide binding]; other site
595495004978	ligand binding site [chemical binding]; other site
595495004979	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
595495004980	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
595495004981	ligand binding site [chemical binding]; other site
595495004982	calcium binding site [ion binding]; other site
595495004983	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
595495004984	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
595495004985	Walker A/P-loop; other site
595495004986	ATP binding site [chemical binding]; other site
595495004987	Q-loop/lid; other site
595495004988	ABC transporter signature motif; other site
595495004989	Walker B; other site
595495004990	D-loop; other site
595495004991	H-loop/switch region; other site
595495004992	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
595495004993	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
595495004994	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
595495004995	TM-ABC transporter signature motif; other site
595495004996	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
595495004997	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
595495004998	homodimer interface [polypeptide binding]; other site
595495004999	active site
595495005000	FMN binding site [chemical binding]; other site
595495005001	substrate binding site [chemical binding]; other site
595495005002	4Fe-4S binding domain; Region: Fer4; pfam00037
595495005003	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
595495005004	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
595495005005	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
595495005006	Protein of unknown function (DUF2542); Region: DUF2542; pfam10808
595495005007	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
595495005008	putative active site [active]
595495005009	cytidine deaminase; Provisional; Region: PRK09027
595495005010	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
595495005011	active site
595495005012	catalytic motif [active]
595495005013	Zn binding site [ion binding]; other site
595495005014	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
595495005015	active site
595495005016	catalytic motif [active]
595495005017	Zn binding site [ion binding]; other site
595495005018	hypothetical protein; Provisional; Region: PRK10711
595495005019	hypothetical protein; Provisional; Region: PRK01821
595495005020	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
595495005021	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
595495005022	FMN binding site [chemical binding]; other site
595495005023	active site
595495005024	catalytic residues [active]
595495005025	substrate binding site [chemical binding]; other site
595495005026	oxidoreductase; Provisional; Region: PRK12743
595495005027	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
595495005028	NAD(P) binding site [chemical binding]; other site
595495005029	active site
595495005030	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
595495005031	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
595495005032	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
595495005033	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
595495005034	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
595495005035	D-lactate dehydrogenase; Provisional; Region: PRK11183
595495005036	FAD binding domain; Region: FAD_binding_4; pfam01565
595495005037	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
595495005038	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
595495005039	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
595495005040	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
595495005041	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
595495005042	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495005043	dimer interface [polypeptide binding]; other site
595495005044	conserved gate region; other site
595495005045	ABC-ATPase subunit interface; other site
595495005046	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
595495005047	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
595495005048	Walker A/P-loop; other site
595495005049	ATP binding site [chemical binding]; other site
595495005050	Q-loop/lid; other site
595495005051	ABC transporter signature motif; other site
595495005052	Walker B; other site
595495005053	D-loop; other site
595495005054	H-loop/switch region; other site
595495005055	CBS domain; Region: CBS; pfam00571
595495005056	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
595495005057	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495005058	dimer interface [polypeptide binding]; other site
595495005059	conserved gate region; other site
595495005060	putative PBP binding loops; other site
595495005061	ABC-ATPase subunit interface; other site
595495005062	hypothetical protein; Provisional; Region: PRK13681
595495005063	transcriptional regulator MirA; Provisional; Region: PRK15043
595495005064	Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763
595495005065	DNA binding residues [nucleotide binding]
595495005066	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
595495005067	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
595495005068	GAF domain; Region: GAF; pfam01590
595495005069	Histidine kinase; Region: His_kinase; pfam06580
595495005070	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495005071	ATP binding site [chemical binding]; other site
595495005072	Mg2+ binding site [ion binding]; other site
595495005073	G-X-G motif; other site
595495005074	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
595495005075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495005076	active site
595495005077	phosphorylation site [posttranslational modification]
595495005078	intermolecular recognition site; other site
595495005079	dimerization interface [polypeptide binding]; other site
595495005080	LytTr DNA-binding domain; Region: LytTR; pfam04397
595495005081	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
595495005082	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
595495005083	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
595495005084	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
595495005085	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
595495005086	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
595495005087	metal ion-dependent adhesion site (MIDAS); other site
595495005088	MoxR-like ATPases [General function prediction only]; Region: COG0714
595495005089	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495005090	Walker A motif; other site
595495005091	ATP binding site [chemical binding]; other site
595495005092	Walker B motif; other site
595495005093	arginine finger; other site
595495005094	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
595495005095	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
595495005096	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
595495005097	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
595495005098	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
595495005099	active site
595495005100	HIGH motif; other site
595495005101	KMSKS motif; other site
595495005102	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
595495005103	tRNA binding surface [nucleotide binding]; other site
595495005104	anticodon binding site; other site
595495005105	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
595495005106	dimer interface [polypeptide binding]; other site
595495005107	putative tRNA-binding site [nucleotide binding]; other site
595495005108	antiporter inner membrane protein; Provisional; Region: PRK11670
595495005109	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
595495005110	Walker A motif; other site
595495005111	Protein of unknown function (DUF2574); Region: DUF2574; pfam10836
595495005112	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
595495005113	putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253
595495005114	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
595495005115	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
595495005116	fimbrial outer membrane usher protein; Provisional; Region: PRK15217
595495005117	PapC N-terminal domain; Region: PapC_N; pfam13954
595495005118	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
595495005119	PapC C-terminal domain; Region: PapC_C; pfam13953
595495005120	putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252
595495005121	putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216
595495005122	Predicted integral membrane protein [Function unknown]; Region: COG5455
595495005123	nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019
595495005124	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
595495005125	putative metal binding site [ion binding]; other site
595495005126	putative homodimer interface [polypeptide binding]; other site
595495005127	putative homotetramer interface [polypeptide binding]; other site
595495005128	putative homodimer-homodimer interface [polypeptide binding]; other site
595495005129	putative allosteric switch controlling residues; other site
595495005130	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
595495005131	substrate binding site [chemical binding]; other site
595495005132	multimerization interface [polypeptide binding]; other site
595495005133	ATP binding site [chemical binding]; other site
595495005134	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
595495005135	dimer interface [polypeptide binding]; other site
595495005136	substrate binding site [chemical binding]; other site
595495005137	ATP binding site [chemical binding]; other site
595495005138	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
595495005139	YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524
595495005140	active site
595495005141	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
595495005142	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495005143	DNA-binding site [nucleotide binding]; DNA binding site
595495005144	UTRA domain; Region: UTRA; pfam07702
595495005145	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
595495005146	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
595495005147	substrate binding site [chemical binding]; other site
595495005148	ATP binding site [chemical binding]; other site
595495005149	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
595495005150	nucleoside transporter; Region: 2A0110; TIGR00889
595495005151	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495005152	putative substrate translocation pore; other site
595495005153	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
595495005154	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
595495005155	putative active site; other site
595495005156	catalytic residue [active]
595495005157	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
595495005158	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
595495005159	intersubunit interface [polypeptide binding]; other site
595495005160	active site
595495005161	zinc binding site [ion binding]; other site
595495005162	Na+ binding site [ion binding]; other site
595495005163	D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052
595495005164	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
595495005165	active site
595495005166	phosphorylation site [posttranslational modification]
595495005167	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
595495005168	active site
595495005169	P-loop; other site
595495005170	phosphorylation site [posttranslational modification]
595495005171	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
595495005172	PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827
595495005173	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
595495005174	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
595495005175	putative NAD(P) binding site [chemical binding]; other site
595495005176	catalytic Zn binding site [ion binding]; other site
595495005177	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
595495005178	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
595495005179	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
595495005180	lipid kinase; Reviewed; Region: PRK13054
595495005181	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
595495005182	integrase; Provisional; Region: int; PHA02601
595495005183	Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family.  They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797
595495005184	dimer interface [polypeptide binding]; other site
595495005185	active site
595495005186	catalytic residues [active]
595495005187	Int/Topo IB signature motif; other site
595495005188	Regulatory phage protein cox; Region: Phage_Cox; pfam10743
595495005189	Protein of unknown function (DUF2732); Region: DUF2732; pfam10809
595495005190	DksA-like zinc finger domain containing protein; Region: PHA00080
595495005191	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
595495005192	AAA domain; Region: AAA_21; pfam13304
595495005193	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495005194	Walker B; other site
595495005195	D-loop; other site
595495005196	H-loop/switch region; other site
595495005197	portal vertex protein; Provisional; Region: Q; PHA02536
595495005198	Phage portal protein; Region: Phage_portal; pfam04860
595495005199	terminase ATPase subunit; Provisional; Region: P; PHA02535
595495005200	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
595495005201	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929
595495005202	Phage major capsid protein, P2 family; Region: Phage_cap_P2; pfam05125
595495005203	terminase endonuclease subunit; Provisional; Region: M; PHA02537
595495005204	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
595495005205	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
595495005206	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
595495005207	Phage holin family 2; Region: Phage_holin_2; pfam04550
595495005208	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
595495005209	N-acetyl-D-glucosamine binding site [chemical binding]; other site
595495005210	catalytic residue [active]
595495005211	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
595495005212	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
595495005213	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
595495005214	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
595495005215	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
595495005216	baseplate wedge subunit; Provisional; Region: W; PHA02516
595495005217	baseplate assembly protein; Provisional; Region: J; PHA02568
595495005218	Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385
595495005219	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
595495005220	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
595495005221	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
595495005222	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
595495005223	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
595495005224	catalytic residues [active]
595495005225	catalytic nucleophile [active]
595495005226	Presynaptic Site I dimer interface [polypeptide binding]; other site
595495005227	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
595495005228	Synaptic Flat tetramer interface [polypeptide binding]; other site
595495005229	Synaptic Site I dimer interface [polypeptide binding]; other site
595495005230	DNA binding site [nucleotide binding]
595495005231	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
595495005232	DNA-binding interface [nucleotide binding]; DNA binding site
595495005233	major tail sheath protein; Provisional; Region: FI; PHA02560
595495005234	major tail tube protein; Provisional; Region: FII; PHA02600
595495005235	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
595495005236	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
595495005237	tail protein; Provisional; Region: D; PHA02561
595495005238	DNA-binding transcriptional regulator; Provisional; Region: PRK09678
595495005239	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
595495005240	putative protease; Provisional; Region: PRK15452
595495005241	Peptidase family U32; Region: Peptidase_U32; pfam01136
595495005242	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
595495005243	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
595495005244	Uncharacterized conserved protein [Function unknown]; Region: COG3422
595495005245	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
595495005246	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
595495005247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495005248	active site
595495005249	phosphorylation site [posttranslational modification]
595495005250	intermolecular recognition site; other site
595495005251	dimerization interface [polypeptide binding]; other site
595495005252	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
595495005253	DNA binding site [nucleotide binding]
595495005254	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
595495005255	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
595495005256	dimerization interface [polypeptide binding]; other site
595495005257	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
595495005258	dimer interface [polypeptide binding]; other site
595495005259	phosphorylation site [posttranslational modification]
595495005260	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495005261	ATP binding site [chemical binding]; other site
595495005262	Mg2+ binding site [ion binding]; other site
595495005263	G-X-G motif; other site
595495005264	putative transporter; Provisional; Region: PRK10504
595495005265	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495005266	putative substrate translocation pore; other site
595495005267	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495005268	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
595495005269	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
595495005270	Protein export membrane protein; Region: SecD_SecF; cl14618
595495005271	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
595495005272	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
595495005273	HlyD family secretion protein; Region: HlyD_3; pfam13437
595495005274	VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464
595495005275	metal ion-dependent adhesion site (MIDAS); other site
595495005276	Protein phosphatase 2C; Region: PP2C_2; pfam13672
595495005277	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779
595495005278	Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077
595495005279	Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248
595495005280	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
595495005281	substrate binding site [chemical binding]; other site
595495005282	activation loop (A-loop); other site
595495005283	Y-family of DNA polymerases; Region: PolY; cl12025
595495005284	putative chaperone; Provisional; Region: PRK11678
595495005285	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
595495005286	nucleotide binding site [chemical binding]; other site
595495005287	putative NEF/HSP70 interaction site [polypeptide binding]; other site
595495005288	SBD interface [polypeptide binding]; other site
595495005289	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
595495005290	AlkA N-terminal domain; Region: AlkA_N; smart01009
595495005291	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
595495005292	minor groove reading motif; other site
595495005293	helix-hairpin-helix signature motif; other site
595495005294	substrate binding pocket [chemical binding]; other site
595495005295	active site
595495005296	Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447
595495005297	putative diguanylate cyclase; Provisional; Region: PRK09776
595495005298	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
595495005299	putative active site [active]
595495005300	heme pocket [chemical binding]; other site
595495005301	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
595495005302	putative active site [active]
595495005303	heme pocket [chemical binding]; other site
595495005304	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
595495005305	putative active site [active]
595495005306	heme pocket [chemical binding]; other site
595495005307	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
595495005308	metal binding site [ion binding]; metal-binding site
595495005309	active site
595495005310	I-site; other site
595495005311	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
595495005312	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
595495005313	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
595495005314	ATP-binding site [chemical binding]; other site
595495005315	Sugar specificity; other site
595495005316	Pyrimidine base specificity; other site
595495005317	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
595495005318	trimer interface [polypeptide binding]; other site
595495005319	active site
595495005320	putative assembly protein; Provisional; Region: PRK10833
595495005321	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
595495005322	Uncharacterized conserved small protein [Function unknown]; Region: COG5606
595495005323	Phage-related protein [Function unknown]; Region: COG4679
595495005324	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
595495005325	FOG: CBS domain [General function prediction only]; Region: COG0517
595495005326	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
595495005327	Transporter associated domain; Region: CorC_HlyC; smart01091
595495005328	polysaccharide export protein Wza; Provisional; Region: PRK15078
595495005329	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
595495005330	SLBB domain; Region: SLBB; pfam10531
595495005331	Low molecular weight phosphatase family; Region: LMWPc; cd00115
595495005332	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
595495005333	active site
595495005334	tyrosine kinase; Provisional; Region: PRK11519
595495005335	Chain length determinant protein; Region: Wzz; pfam02706
595495005336	Chain length determinant protein; Region: Wzz; cl15801
595495005337	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
595495005338	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
595495005339	putative glycosyl transferase; Provisional; Region: PRK10018
595495005340	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
595495005341	active site
595495005342	putative acyl transferase; Provisional; Region: PRK10191
595495005343	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
595495005344	trimer interface [polypeptide binding]; other site
595495005345	active site
595495005346	substrate binding site [chemical binding]; other site
595495005347	CoA binding site [chemical binding]; other site
595495005348	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
595495005349	colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015
595495005350	putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010
595495005351	putative glycosyl transferase; Provisional; Region: PRK10063
595495005352	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
595495005353	metal-binding site
595495005354	colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008
595495005355	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
595495005356	putative trimer interface [polypeptide binding]; other site
595495005357	putative active site [active]
595495005358	putative substrate binding site [chemical binding]; other site
595495005359	putative CoA binding site [chemical binding]; other site
595495005360	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
595495005361	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
595495005362	NADP-binding site; other site
595495005363	homotetramer interface [polypeptide binding]; other site
595495005364	substrate binding site [chemical binding]; other site
595495005365	homodimer interface [polypeptide binding]; other site
595495005366	active site
595495005367	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
595495005368	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
595495005369	NADP binding site [chemical binding]; other site
595495005370	active site
595495005371	putative substrate binding site [chemical binding]; other site
595495005372	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
595495005373	active site
595495005374	GDP-Mannose binding site [chemical binding]; other site
595495005375	dimer interface [polypeptide binding]; other site
595495005376	modified nudix motif
595495005377	metal binding site [ion binding]; metal-binding site
595495005378	colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007
595495005379	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
595495005380	mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460
595495005381	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
595495005382	Substrate binding site; other site
595495005383	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
595495005384	phosphomannomutase CpsG; Provisional; Region: PRK15414
595495005385	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
595495005386	active site
595495005387	substrate binding site [chemical binding]; other site
595495005388	metal binding site [ion binding]; metal-binding site
595495005389	putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124
595495005390	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
595495005391	colanic acid exporter; Provisional; Region: PRK10459
595495005392	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
595495005393	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
595495005394	colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006
595495005395	colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005
595495005396	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
595495005397	putative ADP-binding pocket [chemical binding]; other site
595495005398	putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123
595495005399	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
595495005400	active site
595495005401	tetramer interface; other site
595495005402	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
595495005403	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
595495005404	O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296
595495005405	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
595495005406	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
595495005407	active site
595495005408	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
595495005409	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
595495005410	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
595495005411	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
595495005412	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
595495005413	NAD binding site [chemical binding]; other site
595495005414	homodimer interface [polypeptide binding]; other site
595495005415	active site
595495005416	substrate binding site [chemical binding]; other site
595495005417	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
595495005418	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
595495005419	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
595495005420	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
595495005421	Substrate binding site; other site
595495005422	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
595495005423	phosphomannomutase CpsG; Provisional; Region: PRK15414
595495005424	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
595495005425	active site
595495005426	substrate binding site [chemical binding]; other site
595495005427	metal binding site [ion binding]; metal-binding site
595495005428	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
595495005429	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
595495005430	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
595495005431	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
595495005432	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
595495005433	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
595495005434	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
595495005435	chain length determinant protein WzzB; Provisional; Region: PRK15471
595495005436	Chain length determinant protein; Region: Wzz; pfam02706
595495005437	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
595495005438	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
595495005439	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
595495005440	metal binding site [ion binding]; metal-binding site
595495005441	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
595495005442	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
595495005443	substrate binding site [chemical binding]; other site
595495005444	glutamase interaction surface [polypeptide binding]; other site
595495005445	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
595495005446	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
595495005447	catalytic residues [active]
595495005448	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
595495005449	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
595495005450	putative active site [active]
595495005451	oxyanion strand; other site
595495005452	catalytic triad [active]
595495005453	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
595495005454	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495005455	active site
595495005456	motif I; other site
595495005457	motif II; other site
595495005458	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
595495005459	putative active site pocket [active]
595495005460	4-fold oligomerization interface [polypeptide binding]; other site
595495005461	metal binding residues [ion binding]; metal-binding site
595495005462	3-fold/trimer interface [polypeptide binding]; other site
595495005463	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
595495005464	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
595495005465	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495005466	homodimer interface [polypeptide binding]; other site
595495005467	catalytic residue [active]
595495005468	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
595495005469	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
595495005470	NAD binding site [chemical binding]; other site
595495005471	dimerization interface [polypeptide binding]; other site
595495005472	product binding site; other site
595495005473	substrate binding site [chemical binding]; other site
595495005474	zinc binding site [ion binding]; other site
595495005475	catalytic residues [active]
595495005476	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
595495005477	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
595495005478	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
595495005479	antitoxin YefM; Provisional; Region: PRK11409
595495005480	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
595495005481	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
595495005482	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
595495005483	putative NAD(P) binding site [chemical binding]; other site
595495005484	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495005485	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
595495005486	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
595495005487	dimerization interface [polypeptide binding]; other site
595495005488	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
595495005489	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
595495005490	Sulphur transport; Region: Sulf_transp; pfam04143
595495005491	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
595495005492	CPxP  motif; other site
595495005493	exonuclease I; Provisional; Region: sbcB; PRK11779
595495005494	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
595495005495	active site
595495005496	catalytic site [active]
595495005497	substrate binding site [chemical binding]; other site
595495005498	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
595495005499	D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397
595495005500	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
595495005501	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
595495005502	DNA gyrase inhibitor; Provisional; Region: PRK10016
595495005503	Predicted membrane protein [Function unknown]; Region: COG1289
595495005504	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
595495005505	hypothetical protein; Provisional; Region: PRK05423
595495005506	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
595495005507	homotrimer interface [polypeptide binding]; other site
595495005508	Walker A motif; other site
595495005509	GTP binding site [chemical binding]; other site
595495005510	Walker B motif; other site
595495005511	cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317
595495005512	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
595495005513	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
595495005514	putative dimer interface [polypeptide binding]; other site
595495005515	active site pocket [active]
595495005516	putative cataytic base [active]
595495005517	L,D-transpeptidase; Provisional; Region: PRK10190
595495005518	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
595495005519	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
595495005520	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495005521	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
595495005522	putative dimerization interface [polypeptide binding]; other site
595495005523	transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679
595495005524	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495005525	The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444
595495005526	putative substrate binding site [chemical binding]; other site
595495005527	dimerization interface [polypeptide binding]; other site
595495005528	MATE family multidrug exporter; Provisional; Region: PRK10189
595495005529	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
595495005530	hypothetical protein; Provisional; Region: PRK12378
595495005531	AMP nucleosidase; Provisional; Region: PRK08292
595495005532	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
595495005533	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
595495005534	shikimate transporter; Provisional; Region: PRK09952
595495005535	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495005536	putative substrate translocation pore; other site
595495005537	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
595495005538	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
595495005539	DgsA anti-repressor MtfA; Provisional; Region: PRK15410
595495005540	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
595495005541	zinc/cadmium-binding protein; Provisional; Region: PRK10306
595495005542	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
595495005543	TMAO/DMSO reductase; Reviewed; Region: PRK05363
595495005544	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
595495005545	Moco binding site; other site
595495005546	metal coordination site [ion binding]; other site
595495005547	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
595495005548	active site
595495005549	homotetramer interface [polypeptide binding]; other site
595495005550	transcriptional regulatory protein YedW; Provisional; Region: PRK11517
595495005551	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495005552	active site
595495005553	phosphorylation site [posttranslational modification]
595495005554	intermolecular recognition site; other site
595495005555	dimerization interface [polypeptide binding]; other site
595495005556	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
595495005557	DNA binding site [nucleotide binding]
595495005558	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
595495005559	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
595495005560	dimer interface [polypeptide binding]; other site
595495005561	phosphorylation site [posttranslational modification]
595495005562	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495005563	ATP binding site [chemical binding]; other site
595495005564	Mg2+ binding site [ion binding]; other site
595495005565	G-X-G motif; other site
595495005566	chaperone protein HchA; Provisional; Region: PRK04155
595495005567	Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148
595495005568	dimer interface [polypeptide binding]; other site
595495005569	metal binding site [ion binding]; metal-binding site
595495005570	potential oxyanion hole; other site
595495005571	potential catalytic triad [active]
595495005572	conserved cys residue [active]
595495005573	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
595495005574	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
595495005575	eyelet of channel; other site
595495005576	trimer interface [polypeptide binding]; other site
595495005577	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
595495005578	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
595495005579	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
595495005580	Zn2+ binding site [ion binding]; other site
595495005581	Mg2+ binding site [ion binding]; other site
595495005582	DNA cytosine methylase; Provisional; Region: PRK10458
595495005583	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
595495005584	cofactor binding site; other site
595495005585	DNA binding site [nucleotide binding]
595495005586	substrate interaction site [chemical binding]; other site
595495005587	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
595495005588	additional DNA contacts [nucleotide binding]; other site
595495005589	mismatch recognition site; other site
595495005590	active site
595495005591	zinc binding site [ion binding]; other site
595495005592	DNA intercalation site [nucleotide binding]; other site
595495005593	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
595495005594	EamA-like transporter family; Region: EamA; pfam00892
595495005595	hypothetical protein; Provisional; Region: PRK10062
595495005596	Uncharacterized small protein [Function unknown]; Region: COG5475
595495005597	putative diguanylate cyclase YedQ; Provisional; Region: PRK15426
595495005598	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
595495005599	metal binding site [ion binding]; metal-binding site
595495005600	active site
595495005601	I-site; other site
595495005602	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669
595495005603	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495005604	active site
595495005605	motif I; other site
595495005606	motif II; other site
595495005607	Protein of unknown function (DUF2525); Region: DUF2525; pfam10733
595495005608	hypothetical protein; Provisional; Region: PRK10708
595495005609	colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411
595495005610	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
595495005611	DNA binding residues [nucleotide binding]
595495005612	dimerization interface [polypeptide binding]; other site
595495005613	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
595495005614	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
595495005615	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
595495005616	flagellar biosynthesis protein FliO; Provisional; Region: PRK11486
595495005617	flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963
595495005618	flagellar motor switch protein; Validated; Region: fliN; PRK05698
595495005619	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
595495005620	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
595495005621	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
595495005622	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
595495005623	flagellar hook-length control protein; Provisional; Region: PRK10118
595495005624	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
595495005625	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
595495005626	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960
595495005627	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
595495005628	Walker A motif/ATP binding site; other site
595495005629	Walker B motif; other site
595495005630	flagellar assembly protein H; Validated; Region: fliH; PRK05687
595495005631	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
595495005632	Flagellar assembly protein FliH; Region: FliH; pfam02108
595495005633	flagellar motor switch protein FliG; Region: fliG; TIGR00207
595495005634	FliG C-terminal domain; Region: FliG_C; pfam01706
595495005635	flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206
595495005636	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
595495005637	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
595495005638	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
595495005639	multidrug efflux protein; Reviewed; Region: emrE; PRK09541
595495005640	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
595495005641	substrate binding site [chemical binding]; other site
595495005642	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
595495005643	Transposase IS200 like; Region: Y1_Tnp; pfam01797
595495005644	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
595495005645	Probable transposase; Region: OrfB_IS605; pfam01385
595495005646	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
595495005647	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
595495005648	hypothetical protein; Provisional; Region: PRK09951
595495005649	YedF is a bacterial SirA-like protein of unknown function.  SirA  (also known as UvrY,  and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422
595495005650	CPxP  motif; other site
595495005651	putative inner membrane protein; Provisional; Region: PRK11099
595495005652	lipoprotein; Provisional; Region: PRK10397
595495005653	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
595495005654	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
595495005655	active site
595495005656	Na/Ca binding site [ion binding]; other site
595495005657	catalytic site [active]
595495005658	flagellar biosynthesis protein FliT; Provisional; Region: PRK10548
595495005659	Flagellar protein FliS; Region: FliS; cl00654
595495005660	flagellar capping protein; Reviewed; Region: fliD; PRK08032
595495005661	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
595495005662	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
595495005663	flagellin; Validated; Region: PRK08026
595495005664	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
595495005665	Flagellin protein; Region: FliC; pfam12445
595495005666	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
595495005667	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
595495005668	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
595495005669	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
595495005670	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
595495005671	DNA binding residues [nucleotide binding]
595495005672	flagella biosynthesis protein FliZ; Provisional; Region: PRK11582
595495005673	cystine transporter subunit; Provisional; Region: PRK11260
595495005674	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
595495005675	substrate binding pocket [chemical binding]; other site
595495005676	membrane-bound complex binding site; other site
595495005677	hinge residues; other site
595495005678	D-cysteine desulfhydrase; Validated; Region: PRK03910
595495005679	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
595495005680	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495005681	catalytic residue [active]
595495005682	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
595495005683	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495005684	dimer interface [polypeptide binding]; other site
595495005685	conserved gate region; other site
595495005686	putative PBP binding loops; other site
595495005687	ABC-ATPase subunit interface; other site
595495005688	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
595495005689	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
595495005690	Walker A/P-loop; other site
595495005691	ATP binding site [chemical binding]; other site
595495005692	Q-loop/lid; other site
595495005693	ABC transporter signature motif; other site
595495005694	Walker B; other site
595495005695	D-loop; other site
595495005696	H-loop/switch region; other site
595495005697	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
595495005698	Autoinducer binding domain; Region: Autoind_bind; pfam03472
595495005699	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
595495005700	DNA binding residues [nucleotide binding]
595495005701	dimerization interface [polypeptide binding]; other site
595495005702	hypothetical protein; Provisional; Region: PRK10613
595495005703	response regulator; Provisional; Region: PRK09483
595495005704	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495005705	active site
595495005706	phosphorylation site [posttranslational modification]
595495005707	intermolecular recognition site; other site
595495005708	dimerization interface [polypeptide binding]; other site
595495005709	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
595495005710	DNA binding residues [nucleotide binding]
595495005711	dimerization interface [polypeptide binding]; other site
595495005712	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
595495005713	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
595495005714	GIY-YIG motif/motif A; other site
595495005715	active site
595495005716	catalytic site [active]
595495005717	putative DNA binding site [nucleotide binding]; other site
595495005718	metal binding site [ion binding]; metal-binding site
595495005719	UvrB/uvrC motif; Region: UVR; pfam02151
595495005720	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
595495005721	Helix-hairpin-helix motif; Region: HHH; pfam00633
595495005722	phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832
595495005723	hypothetical protein; Provisional; Region: PRK10396
595495005724	yecA family protein; Region: ygfB_yecA; TIGR02292
595495005725	SEC-C motif; Region: SEC-C; pfam02810
595495005726	tyrosine transporter TyrP; Provisional; Region: PRK15132
595495005727	aromatic amino acid transport protein; Region: araaP; TIGR00837
595495005728	probable metal-binding protein; Region: matur_matur; TIGR03853
595495005729	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
595495005730	Ferritin-like domain; Region: Ferritin; pfam00210
595495005731	ferroxidase diiron center [ion binding]; other site
595495005732	YecR-like lipoprotein; Region: YecR; pfam13992
595495005733	Protein of unknown function (DUF2766); Region: DUF2766; pfam10964
595495005734	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
595495005735	Ferritin-like domain; Region: Ferritin; pfam00210
595495005736	ferroxidase diiron center [ion binding]; other site
595495005737	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
595495005738	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
595495005739	ligand binding site [chemical binding]; other site
595495005740	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
595495005741	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
595495005742	Walker A/P-loop; other site
595495005743	ATP binding site [chemical binding]; other site
595495005744	Q-loop/lid; other site
595495005745	ABC transporter signature motif; other site
595495005746	Walker B; other site
595495005747	D-loop; other site
595495005748	H-loop/switch region; other site
595495005749	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
595495005750	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
595495005751	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
595495005752	TM-ABC transporter signature motif; other site
595495005753	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187
595495005754	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
595495005755	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
595495005756	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
595495005757	active site
595495005758	homotetramer interface [polypeptide binding]; other site
595495005759	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
595495005760	Ligand Binding Site [chemical binding]; other site
595495005761	transcriptional activator FlhD; Provisional; Region: PRK02909
595495005762	transcriptional activator FlhC; Provisional; Region: PRK12722
595495005763	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
595495005764	flagellar motor protein MotA; Validated; Region: PRK09110
595495005765	flagellar motor protein MotB; Validated; Region: motB; PRK09041
595495005766	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
595495005767	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
595495005768	ligand binding site [chemical binding]; other site
595495005769	chemotaxis protein CheA; Provisional; Region: PRK10547
595495005770	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
595495005771	putative binding surface; other site
595495005772	active site
595495005773	CheY binding; Region: CheY-binding; pfam09078
595495005774	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
595495005775	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495005776	ATP binding site [chemical binding]; other site
595495005777	Mg2+ binding site [ion binding]; other site
595495005778	G-X-G motif; other site
595495005779	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
595495005780	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
595495005781	putative CheA interaction surface; other site
595495005782	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
595495005783	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
595495005784	dimer interface [polypeptide binding]; other site
595495005785	ligand binding site [chemical binding]; other site
595495005786	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
595495005787	dimerization interface [polypeptide binding]; other site
595495005788	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
595495005789	dimer interface [polypeptide binding]; other site
595495005790	putative CheW interface [polypeptide binding]; other site
595495005791	methyl-accepting protein IV; Provisional; Region: PRK09793
595495005792	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
595495005793	dimer interface [polypeptide binding]; other site
595495005794	ligand binding site [chemical binding]; other site
595495005795	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
595495005796	dimerization interface [polypeptide binding]; other site
595495005797	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
595495005798	dimer interface [polypeptide binding]; other site
595495005799	putative CheW interface [polypeptide binding]; other site
595495005800	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
595495005801	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
595495005802	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495005803	S-adenosylmethionine binding site [chemical binding]; other site
595495005804	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
595495005805	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495005806	active site
595495005807	phosphorylation site [posttranslational modification]
595495005808	intermolecular recognition site; other site
595495005809	dimerization interface [polypeptide binding]; other site
595495005810	CheB methylesterase; Region: CheB_methylest; pfam01339
595495005811	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
595495005812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495005813	active site
595495005814	phosphorylation site [posttranslational modification]
595495005815	intermolecular recognition site; other site
595495005816	dimerization interface [polypeptide binding]; other site
595495005817	chemotaxis regulator CheZ; Provisional; Region: PRK11166
595495005818	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
595495005819	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
595495005820	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
595495005821	FHIPEP family; Region: FHIPEP; pfam00771
595495005822	Flagellar protein FlhE; Region: FlhE; pfam06366
595495005823	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
595495005824	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
595495005825	arginyl-tRNA synthetase; Region: argS; TIGR00456
595495005826	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
595495005827	active site
595495005828	HIGH motif; other site
595495005829	KMSK motif region; other site
595495005830	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
595495005831	tRNA binding surface [nucleotide binding]; other site
595495005832	anticodon binding site; other site
595495005833	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
595495005834	putative metal binding site [ion binding]; other site
595495005835	copper homeostasis protein CutC; Provisional; Region: PRK11572
595495005836	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
595495005837	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
595495005838	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
595495005839	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
595495005840	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
595495005841	molybdopterin cofactor binding site [chemical binding]; other site
595495005842	substrate binding site [chemical binding]; other site
595495005843	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
595495005844	molybdopterin cofactor binding site; other site
595495005845	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495005846	S-adenosylmethionine binding site [chemical binding]; other site
595495005847	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495005848	S-adenosylmethionine binding site [chemical binding]; other site
595495005849	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
595495005850	hypothetical protein; Provisional; Region: PRK10302
595495005851	Isochorismatase family; Region: Isochorismatase; pfam00857
595495005852	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
595495005853	catalytic triad [active]
595495005854	conserved cis-peptide bond; other site
595495005855	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
595495005856	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
595495005857	dimer interface [polypeptide binding]; other site
595495005858	anticodon binding site; other site
595495005859	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
595495005860	homodimer interface [polypeptide binding]; other site
595495005861	motif 1; other site
595495005862	active site
595495005863	motif 2; other site
595495005864	GAD domain; Region: GAD; pfam02938
595495005865	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
595495005866	motif 3; other site
595495005867	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
595495005868	nudix motif; other site
595495005869	hypothetical protein; Validated; Region: PRK00110
595495005870	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
595495005871	active site
595495005872	putative DNA-binding cleft [nucleotide binding]; other site
595495005873	dimer interface [polypeptide binding]; other site
595495005874	hypothetical protein; Provisional; Region: PRK11470
595495005875	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
595495005876	RuvA N terminal domain; Region: RuvA_N; pfam01330
595495005877	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
595495005878	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
595495005879	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495005880	Walker A motif; other site
595495005881	ATP binding site [chemical binding]; other site
595495005882	Walker B motif; other site
595495005883	arginine finger; other site
595495005884	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
595495005885	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
595495005886	Transposase; Region: DEDD_Tnp_IS110; pfam01548
595495005887	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
595495005888	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
595495005889	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
595495005890	ABC-ATPase subunit  interface; other site
595495005891	dimer interface [polypeptide binding]; other site
595495005892	putative PBP binding regions; other site
595495005893	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
595495005894	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
595495005895	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
595495005896	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
595495005897	metal binding site [ion binding]; metal-binding site
595495005898	putative peptidase; Provisional; Region: PRK11649
595495005899	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
595495005900	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
595495005901	Peptidase family M23; Region: Peptidase_M23; pfam01551
595495005902	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
595495005903	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
595495005904	putative acyl-acceptor binding pocket; other site
595495005905	pyruvate kinase; Provisional; Region: PRK05826
595495005906	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
595495005907	domain interfaces; other site
595495005908	active site
595495005909	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
595495005910	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
595495005911	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
595495005912	putative active site [active]
595495005913	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
595495005914	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
595495005915	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
595495005916	phosphogluconate dehydratase; Validated; Region: PRK09054
595495005917	6-phosphogluconate dehydratase; Region: edd; TIGR01196
595495005918	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
595495005919	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
595495005920	active site
595495005921	intersubunit interface [polypeptide binding]; other site
595495005922	catalytic residue [active]
595495005923	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
595495005924	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
595495005925	ATP-grasp domain; Region: ATP-grasp; pfam02222
595495005926	DNA damage-inducible protein YebG; Provisional; Region: PRK10061
595495005927	hypothetical protein; Provisional; Region: PRK13680
595495005928	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
595495005929	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
595495005930	putative metal binding site [ion binding]; other site
595495005931	protease 2; Provisional; Region: PRK10115
595495005932	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
595495005933	exodeoxyribonuclease X; Provisional; Region: PRK07983
595495005934	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
595495005935	active site
595495005936	catalytic site [active]
595495005937	substrate binding site [chemical binding]; other site
595495005938	Predicted amidohydrolase [General function prediction only]; Region: COG0388
595495005939	Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795
595495005940	DNA polymerase III subunit theta; Reviewed; Region: PRK10969
595495005941	hypothetical protein; Provisional; Region: PRK10301
595495005942	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
595495005943	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
595495005944	serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439
595495005945	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
595495005946	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
595495005947	Protein of unknown function (DUF1480); Region: DUF1480; pfam07351
595495005948	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
595495005949	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495005950	S-adenosylmethionine binding site [chemical binding]; other site
595495005951	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
595495005952	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
595495005953	mce related protein; Region: MCE; pfam02470
595495005954	mce related protein; Region: MCE; pfam02470
595495005955	mce related protein; Region: MCE; pfam02470
595495005956	mce related protein; Region: MCE; pfam02470
595495005957	mce related protein; Region: MCE; pfam02470
595495005958	integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155
595495005959	Paraquat-inducible protein A; Region: PqiA; pfam04403
595495005960	Paraquat-inducible protein A; Region: PqiA; pfam04403
595495005961	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
595495005962	GAF domain; Region: GAF_2; pfam13185
595495005963	ProP expression regulator; Provisional; Region: PRK04950
595495005964	ProQ/FINO family; Region: ProQ; pfam04352
595495005965	carboxy-terminal protease; Provisional; Region: PRK11186
595495005966	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
595495005967	protein binding site [polypeptide binding]; other site
595495005968	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
595495005969	Catalytic dyad [active]
595495005970	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
595495005971	heat shock protein HtpX; Provisional; Region: PRK05457
595495005972	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495005973	Major Facilitator Superfamily; Region: MFS_1; pfam07690
595495005974	putative substrate translocation pore; other site
595495005975	Predicted integral membrane protein [Function unknown]; Region: COG5521
595495005976	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
595495005977	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
595495005978	dimerization interface [polypeptide binding]; other site
595495005979	putative Zn2+ binding site [ion binding]; other site
595495005980	putative DNA binding site [nucleotide binding]; other site
595495005981	Bacterial transcriptional regulator; Region: IclR; pfam01614
595495005982	YobH-like protein; Region: YobH; pfam13996
595495005983	YebO-like protein; Region: YebO; pfam13974
595495005984	Protein of unknown function (DUF2627); Region: DUF2527; pfam10736
595495005985	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
595495005986	DNA-binding site [nucleotide binding]; DNA binding site
595495005987	RNA-binding motif; other site
595495005988	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
595495005989	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495005990	S-adenosylmethionine binding site [chemical binding]; other site
595495005991	hypothetical protein; Provisional; Region: PRK11469
595495005992	Domain of unknown function DUF; Region: DUF204; pfam02659
595495005993	Domain of unknown function DUF; Region: DUF204; pfam02659
595495005994	Predicted membrane protein [Function unknown]; Region: COG4811
595495005995	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
595495005996	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
595495005997	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
595495005998	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
595495005999	active pocket/dimerization site; other site
595495006000	active site
595495006001	phosphorylation site [posttranslational modification]
595495006002	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
595495006003	active site
595495006004	phosphorylation site [posttranslational modification]
595495006005	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
595495006006	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
595495006007	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
595495006008	Transporter associated domain; Region: CorC_HlyC; smart01091
595495006009	phage resistance protein; Provisional; Region: PRK10551
595495006010	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
595495006011	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
595495006012	L-serine deaminase; Provisional; Region: PRK15023
595495006013	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
595495006014	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
595495006015	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
595495006016	putative active site [active]
595495006017	putative CoA binding site [chemical binding]; other site
595495006018	nudix motif; other site
595495006019	metal binding site [ion binding]; metal-binding site
595495006020	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
595495006021	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
595495006022	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
595495006023	hypothetical protein; Provisional; Region: PRK05114
595495006024	Domain of unknown function (DUF1889); Region: DUF1889; pfam08986
595495006025	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
595495006026	homotrimer interaction site [polypeptide binding]; other site
595495006027	putative active site [active]
595495006028	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
595495006029	DEAD/DEAH box helicase; Region: DEAD; pfam00270
595495006030	DEAD_2; Region: DEAD_2; pfam06733
595495006031	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
595495006032	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
595495006033	Glycoprotease family; Region: Peptidase_M22; pfam00814
595495006034	outer membrane lipoprotein, Slp family; Region: slp; TIGR00752
595495006035	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
595495006036	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
595495006037	acyl-activating enzyme (AAE) consensus motif; other site
595495006038	putative AMP binding site [chemical binding]; other site
595495006039	putative active site [active]
595495006040	putative CoA binding site [chemical binding]; other site
595495006041	ribonuclease D; Provisional; Region: PRK10829
595495006042	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
595495006043	catalytic site [active]
595495006044	putative active site [active]
595495006045	putative substrate binding site [chemical binding]; other site
595495006046	Helicase and RNase D C-terminal; Region: HRDC; smart00341
595495006047	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
595495006048	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
595495006049	FMN-binding pocket [chemical binding]; other site
595495006050	flavin binding motif; other site
595495006051	phosphate binding motif [ion binding]; other site
595495006052	beta-alpha-beta structure motif; other site
595495006053	NAD binding pocket [chemical binding]; other site
595495006054	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
595495006055	catalytic loop [active]
595495006056	iron binding site [ion binding]; other site
595495006057	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
595495006058	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
595495006059	[2Fe-2S] cluster binding site [ion binding]; other site
595495006060	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886
595495006061	putative alpha subunit interface [polypeptide binding]; other site
595495006062	putative active site [active]
595495006063	putative substrate binding site [chemical binding]; other site
595495006064	Fe binding site [ion binding]; other site
595495006065	putative transporter; Provisional; Region: PRK09950
595495006066	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
595495006067	tartrate dehydrogenase; Region: TTC; TIGR02089
595495006068	transcriptional activator TtdR; Provisional; Region: PRK09801
595495006069	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495006070	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
595495006071	putative effector binding pocket; other site
595495006072	putative dimerization interface [polypeptide binding]; other site
595495006073	leucine export protein LeuE; Provisional; Region: PRK10958
595495006074	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
595495006075	Domain of unknown function (DUF1869); Region: DUF1869; pfam08956
595495006076	Transposase IS200 like; Region: Y1_Tnp; pfam01797
595495006077	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
595495006078	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
595495006079	Probable transposase; Region: OrfB_IS605; pfam01385
595495006080	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
595495006081	hypothetical protein; Provisional; Region: PRK10457
595495006082	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
595495006083	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
595495006084	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
595495006085	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
595495006086	metal binding site [ion binding]; metal-binding site
595495006087	active site
595495006088	I-site; other site
595495006089	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
595495006090	Domain of unknown function (DUF333); Region: DUF333; pfam03891
595495006091	Uncharacterized conserved protein [Function unknown]; Region: COG3189
595495006092	cyanate transporter; Region: CynX; TIGR00896
595495006093	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495006094	putative substrate translocation pore; other site
595495006095	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
595495006096	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495006097	Predicted membrane protein [Function unknown]; Region: COG2707
595495006098	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
595495006099	putative deacylase active site [active]
595495006100	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
595495006101	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
595495006102	metal binding site [ion binding]; metal-binding site
595495006103	active site
595495006104	I-site; other site
595495006105	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
595495006106	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
595495006107	metal binding site [ion binding]; metal-binding site
595495006108	active site
595495006109	I-site; other site
595495006110	hypothetical protein; Provisional; Region: PRK05325
595495006111	PrkA family serine protein kinase; Provisional; Region: PRK15455
595495006112	AAA ATPase domain; Region: AAA_16; pfam13191
595495006113	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
595495006114	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
595495006115	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
595495006116	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
595495006117	active site
595495006118	catalytic tetrad [active]
595495006119	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
595495006120	active site
595495006121	phosphate binding residues; other site
595495006122	catalytic residues [active]
595495006123	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
595495006124	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
595495006125	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
595495006126	methionine sulfoxide reductase B; Provisional; Region: PRK00222
595495006127	SelR domain; Region: SelR; pfam01641
595495006128	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139
595495006129	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
595495006130	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
595495006131	putative NAD(P) binding site [chemical binding]; other site
595495006132	catalytic Zn binding site [ion binding]; other site
595495006133	structural Zn binding site [ion binding]; other site
595495006134	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495006135	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495006136	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
595495006137	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
595495006138	inhibitor binding site; inhibition site
595495006139	catalytic Zn binding site [ion binding]; other site
595495006140	structural Zn binding site [ion binding]; other site
595495006141	NADP binding site [chemical binding]; other site
595495006142	tetramer interface [polypeptide binding]; other site
595495006143	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
595495006144	intersubunit interface [polypeptide binding]; other site
595495006145	active site
595495006146	zinc binding site [ion binding]; other site
595495006147	Na+ binding site [ion binding]; other site
595495006148	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
595495006149	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
595495006150	substrate binding site [chemical binding]; other site
595495006151	ATP binding site [chemical binding]; other site
595495006152	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
595495006153	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
595495006154	active site
595495006155	catalytic tetrad [active]
595495006156	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
595495006157	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
595495006158	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
595495006159	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
595495006160	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495006161	putative substrate translocation pore; other site
595495006162	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495006163	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
595495006164	Isochorismatase family; Region: Isochorismatase; pfam00857
595495006165	catalytic triad [active]
595495006166	metal binding site [ion binding]; metal-binding site
595495006167	conserved cis-peptide bond; other site
595495006168	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
595495006169	active site
595495006170	homodimer interface [polypeptide binding]; other site
595495006171	protease 4; Provisional; Region: PRK10949
595495006172	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
595495006173	tandem repeat interface [polypeptide binding]; other site
595495006174	oligomer interface [polypeptide binding]; other site
595495006175	active site residues [active]
595495006176	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019
595495006177	tandem repeat interface [polypeptide binding]; other site
595495006178	oligomer interface [polypeptide binding]; other site
595495006179	active site residues [active]
595495006180	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
595495006181	putative FMN binding site [chemical binding]; other site
595495006182	selenophosphate synthetase; Provisional; Region: PRK00943
595495006183	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
595495006184	dimerization interface [polypeptide binding]; other site
595495006185	putative ATP binding site [chemical binding]; other site
595495006186	DNA topoisomerase III; Provisional; Region: PRK07726
595495006187	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
595495006188	active site
595495006189	putative interdomain interaction site [polypeptide binding]; other site
595495006190	putative metal-binding site [ion binding]; other site
595495006191	putative nucleotide binding site [chemical binding]; other site
595495006192	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
595495006193	domain I; other site
595495006194	DNA binding groove [nucleotide binding]
595495006195	phosphate binding site [ion binding]; other site
595495006196	domain II; other site
595495006197	domain III; other site
595495006198	nucleotide binding site [chemical binding]; other site
595495006199	catalytic site [active]
595495006200	domain IV; other site
595495006201	hypothetical protein; Provisional; Region: PRK11380
595495006202	glutamate dehydrogenase; Provisional; Region: PRK09414
595495006203	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
595495006204	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
595495006205	NAD(P) binding site [chemical binding]; other site
595495006206	Protein of unknown function (DUF1496); Region: DUF1496; pfam07383
595495006207	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
595495006208	active site
595495006209	8-oxo-dGMP binding site [chemical binding]; other site
595495006210	nudix motif; other site
595495006211	metal binding site [ion binding]; metal-binding site
595495006212	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
595495006213	Rhodanese Homology Domain; Region: RHOD; smart00450
595495006214	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
595495006215	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
595495006216	active site residue [active]
595495006217	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
595495006218	active site residue [active]
595495006219	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136
595495006220	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495006221	Walker A/P-loop; other site
595495006222	ATP binding site [chemical binding]; other site
595495006223	Q-loop/lid; other site
595495006224	ABC transporter signature motif; other site
595495006225	Walker B; other site
595495006226	D-loop; other site
595495006227	H-loop/switch region; other site
595495006228	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135
595495006229	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495006230	dimer interface [polypeptide binding]; other site
595495006231	conserved gate region; other site
595495006232	putative PBP binding loops; other site
595495006233	ABC-ATPase subunit interface; other site
595495006234	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
595495006235	hypothetical protein; Provisional; Region: PRK11622
595495006236	Uncharacterized conserved protein [Function unknown]; Region: COG2128
595495006237	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
595495006238	Uncharacterized conserved protein [Function unknown]; Region: COG0398
595495006239	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
595495006240	Uncharacterized conserved protein [Function unknown]; Region: COG0398
595495006241	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
595495006242	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
595495006243	putative catalytic site [active]
595495006244	putative phosphate binding site [ion binding]; other site
595495006245	active site
595495006246	metal binding site A [ion binding]; metal-binding site
595495006247	DNA binding site [nucleotide binding]
595495006248	putative AP binding site [nucleotide binding]; other site
595495006249	putative metal binding site B [ion binding]; other site
595495006250	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
595495006251	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
595495006252	inhibitor-cofactor binding pocket; inhibition site
595495006253	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495006254	catalytic residue [active]
595495006255	arginine succinyltransferase; Provisional; Region: PRK10456
595495006256	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
595495006257	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
595495006258	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
595495006259	NAD(P) binding site [chemical binding]; other site
595495006260	catalytic residues [active]
595495006261	succinylarginine dihydrolase; Provisional; Region: PRK13281
595495006262	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
595495006263	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
595495006264	putative active site [active]
595495006265	Zn binding site [ion binding]; other site
595495006266	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
595495006267	dimer interface [polypeptide binding]; other site
595495006268	hypothetical protein; Provisional; Region: PRK11396
595495006269	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
595495006270	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
595495006271	GIY-YIG motif/motif A; other site
595495006272	active site
595495006273	catalytic site [active]
595495006274	putative DNA binding site [nucleotide binding]; other site
595495006275	metal binding site [ion binding]; metal-binding site
595495006276	NAD+ synthetase; Region: nadE; TIGR00552
595495006277	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
595495006278	homodimer interface [polypeptide binding]; other site
595495006279	NAD binding pocket [chemical binding]; other site
595495006280	ATP binding pocket [chemical binding]; other site
595495006281	Mg binding site [ion binding]; other site
595495006282	active-site loop [active]
595495006283	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
595495006284	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
595495006285	active site
595495006286	P-loop; other site
595495006287	phosphorylation site [posttranslational modification]
595495006288	PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297
595495006289	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
595495006290	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
595495006291	methionine cluster; other site
595495006292	active site
595495006293	phosphorylation site [posttranslational modification]
595495006294	metal binding site [ion binding]; metal-binding site
595495006295	DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296
595495006296	Cupin domain; Region: Cupin_2; pfam07883
595495006297	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495006298	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
595495006299	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
595495006300	NAD binding site [chemical binding]; other site
595495006301	sugar binding site [chemical binding]; other site
595495006302	divalent metal binding site [ion binding]; other site
595495006303	tetramer (dimer of dimers) interface [polypeptide binding]; other site
595495006304	dimer interface [polypeptide binding]; other site
595495006305	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
595495006306	putative active site [active]
595495006307	YdjC motif; other site
595495006308	Mg binding site [ion binding]; other site
595495006309	putative homodimer interface [polypeptide binding]; other site
595495006310	hydroperoxidase II; Provisional; Region: katE; PRK11249
595495006311	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
595495006312	tetramer interface [polypeptide binding]; other site
595495006313	heme binding pocket [chemical binding]; other site
595495006314	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
595495006315	domain interactions; other site
595495006316	cell division modulator; Provisional; Region: PRK10113
595495006317	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
595495006318	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
595495006319	inner membrane protein; Provisional; Region: PRK11648
595495006320	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
595495006321	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
595495006322	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495006323	motif II; other site
595495006324	YniB-like protein; Region: YniB; pfam14002
595495006325	Phosphotransferase enzyme family; Region: APH; pfam01636
595495006326	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
595495006327	active site
595495006328	ATP binding site [chemical binding]; other site
595495006329	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
595495006330	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
595495006331	6-phosphofructokinase 2; Provisional; Region: PRK10294
595495006332	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
595495006333	putative substrate binding site [chemical binding]; other site
595495006334	putative ATP binding site [chemical binding]; other site
595495006335	Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137
595495006336	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
595495006337	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
595495006338	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
595495006339	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
595495006340	active site
595495006341	dimer interface [polypeptide binding]; other site
595495006342	motif 1; other site
595495006343	motif 2; other site
595495006344	motif 3; other site
595495006345	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
595495006346	anticodon binding site; other site
595495006347	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
595495006348	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
595495006349	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
595495006350	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
595495006351	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
595495006352	23S rRNA binding site [nucleotide binding]; other site
595495006353	L21 binding site [polypeptide binding]; other site
595495006354	L13 binding site [polypeptide binding]; other site
595495006355	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
595495006356	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
595495006357	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
595495006358	dimer interface [polypeptide binding]; other site
595495006359	motif 1; other site
595495006360	active site
595495006361	motif 2; other site
595495006362	motif 3; other site
595495006363	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
595495006364	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
595495006365	putative tRNA-binding site [nucleotide binding]; other site
595495006366	B3/4 domain; Region: B3_4; pfam03483
595495006367	tRNA synthetase B5 domain; Region: B5; smart00874
595495006368	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
595495006369	dimer interface [polypeptide binding]; other site
595495006370	motif 1; other site
595495006371	motif 3; other site
595495006372	motif 2; other site
595495006373	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
595495006374	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
595495006375	IHF dimer interface [polypeptide binding]; other site
595495006376	IHF - DNA interface [nucleotide binding]; other site
595495006377	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
595495006378	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
595495006379	ABC-ATPase subunit  interface; other site
595495006380	dimer interface [polypeptide binding]; other site
595495006381	putative PBP binding regions; other site
595495006382	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
595495006383	catalytic residues [active]
595495006384	dimer interface [polypeptide binding]; other site
595495006385	vitamin B12-transporter ATPase; Provisional; Region: PRK03695
595495006386	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
595495006387	Walker A/P-loop; other site
595495006388	ATP binding site [chemical binding]; other site
595495006389	Q-loop/lid; other site
595495006390	ABC transporter signature motif; other site
595495006391	Walker B; other site
595495006392	D-loop; other site
595495006393	H-loop/switch region; other site
595495006394	NlpC/P60 family; Region: NLPC_P60; pfam00877
595495006395	c-di-GMP phosphodiesterase class I (EAL domain) [Signal    transduction mechanisms]; Region: Rtn; COG2200
595495006396	Uncharacterized conserved protein [Function unknown]; Region: COG0397
595495006397	hypothetical protein; Validated; Region: PRK00029
595495006398	Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256
595495006399	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
595495006400	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
595495006401	PEP synthetase regulatory protein; Provisional; Region: PRK05339
595495006402	phosphoenolpyruvate synthase; Validated; Region: PRK06464
595495006403	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
595495006404	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
595495006405	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
595495006406	short chain acyl-CoA synthetase; Reviewed; Region: PRK06087
595495006407	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
595495006408	acyl-activating enzyme (AAE) consensus motif; other site
595495006409	putative AMP binding site [chemical binding]; other site
595495006410	putative active site [active]
595495006411	putative CoA binding site [chemical binding]; other site
595495006412	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
595495006413	oxidoreductase; Provisional; Region: PRK10015
595495006414	electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916
595495006415	Electron transfer flavoprotein domain; Region: ETF; smart00893
595495006416	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
595495006417	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
595495006418	Ligand binding site [chemical binding]; other site
595495006419	Electron transfer flavoprotein domain; Region: ETF; pfam01012
595495006420	Cupin domain; Region: Cupin_2; pfam07883
595495006421	Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336
595495006422	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
595495006423	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495006424	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
595495006425	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
595495006426	active site
595495006427	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
595495006428	Coenzyme A transferase; Region: CoA_trans; smart00882
595495006429	Coenzyme A transferase; Region: CoA_trans; cl17247
595495006430	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
595495006431	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
595495006432	active site
595495006433	catalytic residue [active]
595495006434	dimer interface [polypeptide binding]; other site
595495006435	quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749
595495006436	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
595495006437	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
595495006438	shikimate binding site; other site
595495006439	NAD(P) binding site [chemical binding]; other site
595495006440	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495006441	putative substrate translocation pore; other site
595495006442	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495006443	Major Facilitator Superfamily; Region: MFS_1; pfam07690
595495006444	putative substrate translocation pore; other site
595495006445	Domain of unknown function (DUF1870); Region: DUF1870; pfam08965
595495006446	putative inner membrane protein; Provisional; Region: PRK10983
595495006447	Domain of unknown function DUF20; Region: UPF0118; pfam01594
595495006448	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
595495006449	FAD binding domain; Region: FAD_binding_4; pfam01565
595495006450	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
595495006451	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
595495006452	CoenzymeA binding site [chemical binding]; other site
595495006453	subunit interaction site [polypeptide binding]; other site
595495006454	PHB binding site; other site
595495006455	iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504
595495006456	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
595495006457	putative ABC transporter; Region: ycf24; CHL00085
595495006458	cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580
595495006459	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
595495006460	Walker A/P-loop; other site
595495006461	ATP binding site [chemical binding]; other site
595495006462	Q-loop/lid; other site
595495006463	ABC transporter signature motif; other site
595495006464	Walker B; other site
595495006465	D-loop; other site
595495006466	H-loop/switch region; other site
595495006467	cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948
595495006468	FeS assembly protein SufD; Region: sufD; TIGR01981
595495006469	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
595495006470	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
595495006471	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
595495006472	catalytic residue [active]
595495006473	cysteine desufuration protein SufE; Provisional; Region: PRK09296
595495006474	L,D-transpeptidase; Provisional; Region: PRK10190
595495006475	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
595495006476	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
595495006477	murein lipoprotein; Provisional; Region: PRK15396
595495006478	pyruvate kinase; Provisional; Region: PRK09206
595495006479	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
595495006480	domain interfaces; other site
595495006481	active site
595495006482	hypothetical protein; Provisional; Region: PRK10292
595495006483	hypothetical protein; Provisional; Region: PRK09898
595495006484	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
595495006485	putative oxidoreductase; Provisional; Region: PRK09849
595495006486	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
595495006487	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
595495006488	hypothetical protein; Provisional; Region: PRK09947
595495006489	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
595495006490	thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006
595495006491	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
595495006492	hypothetical protein; Provisional; Region: PRK09946
595495006493	hypothetical protein; Provisional; Region: PRK09897
595495006494	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
595495006495	putative monooxygenase; Provisional; Region: PRK11118
595495006496	hypothetical protein; Provisional; Region: PRK09945
595495006497	Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468
595495006498	multidrug efflux protein; Reviewed; Region: PRK01766
595495006499	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
595495006500	cation binding site [ion binding]; other site
595495006501	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
595495006502	Lumazine binding domain; Region: Lum_binding; pfam00677
595495006503	Lumazine binding domain; Region: Lum_binding; pfam00677
595495006504	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
595495006505	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
595495006506	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495006507	S-adenosylmethionine binding site [chemical binding]; other site
595495006508	putative transporter; Provisional; Region: PRK11043
595495006509	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495006510	putative substrate translocation pore; other site
595495006511	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
595495006512	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495006513	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
595495006514	dimerization interface [polypeptide binding]; other site
595495006515	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
595495006516	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
595495006517	DNA binding site [nucleotide binding]
595495006518	domain linker motif; other site
595495006519	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
595495006520	dimerization interface [polypeptide binding]; other site
595495006521	ligand binding site [chemical binding]; other site
595495006522	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495006523	Major Facilitator Superfamily; Region: MFS_1; pfam07690
595495006524	putative substrate translocation pore; other site
595495006525	superoxide dismutase; Provisional; Region: PRK10543
595495006526	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
595495006527	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
595495006528	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
595495006529	NlpC/P60 family; Region: NLPC_P60; pfam00877
595495006530	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
595495006531	putative GSH binding site [chemical binding]; other site
595495006532	catalytic residues [active]
595495006533	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
595495006534	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
595495006535	ATP binding site [chemical binding]; other site
595495006536	putative Mg++ binding site [ion binding]; other site
595495006537	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
595495006538	nucleotide binding region [chemical binding]; other site
595495006539	ATP-binding site [chemical binding]; other site
595495006540	DEAD/H associated; Region: DEAD_assoc; pfam08494
595495006541	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
595495006542	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
595495006543	dimer interface [polypeptide binding]; other site
595495006544	catalytic site [active]
595495006545	putative active site [active]
595495006546	putative substrate binding site [chemical binding]; other site
595495006547	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
595495006548	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
595495006549	dimer interface [polypeptide binding]; other site
595495006550	active site
595495006551	metal binding site [ion binding]; metal-binding site
595495006552	glutathione binding site [chemical binding]; other site
595495006553	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
595495006554	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
595495006555	FMN binding site [chemical binding]; other site
595495006556	active site
595495006557	substrate binding site [chemical binding]; other site
595495006558	catalytic residue [active]
595495006559	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
595495006560	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
595495006561	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
595495006562	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
595495006563	active site
595495006564	catalytic tetrad [active]
595495006565	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
595495006566	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
595495006567	E-class dimer interface [polypeptide binding]; other site
595495006568	P-class dimer interface [polypeptide binding]; other site
595495006569	active site
595495006570	Cu2+ binding site [ion binding]; other site
595495006571	Zn2+ binding site [ion binding]; other site
595495006572	Fusaric acid resistance protein family; Region: FUSC; pfam04632
595495006573	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
595495006574	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
595495006575	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
595495006576	HlyD family secretion protein; Region: HlyD_3; pfam13437
595495006577	Protein of unknown function (DUF1656); Region: DUF1656; cl11658
595495006578	transcriptional regulator SlyA; Provisional; Region: PRK03573
595495006579	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
595495006580	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
595495006581	Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702
595495006582	lysozyme inhibitor; Provisional; Region: PRK11372
595495006583	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
595495006584	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
595495006585	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
595495006586	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
595495006587	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
595495006588	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
595495006589	active site
595495006590	HIGH motif; other site
595495006591	dimer interface [polypeptide binding]; other site
595495006592	KMSKS motif; other site
595495006593	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
595495006594	RNA binding surface [nucleotide binding]; other site
595495006595	pyridoxamine kinase; Validated; Region: PRK05756
595495006596	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
595495006597	dimer interface [polypeptide binding]; other site
595495006598	pyridoxal binding site [chemical binding]; other site
595495006599	ATP binding site [chemical binding]; other site
595495006600	glutathionine S-transferase; Provisional; Region: PRK10542
595495006601	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
595495006602	C-terminal domain interface [polypeptide binding]; other site
595495006603	GSH binding site (G-site) [chemical binding]; other site
595495006604	dimer interface [polypeptide binding]; other site
595495006605	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
595495006606	N-terminal domain interface [polypeptide binding]; other site
595495006607	dimer interface [polypeptide binding]; other site
595495006608	substrate binding pocket (H-site) [chemical binding]; other site
595495006609	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
595495006610	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495006611	putative substrate translocation pore; other site
595495006612	POT family; Region: PTR2; pfam00854
595495006613	endonuclease III; Provisional; Region: PRK10702
595495006614	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
595495006615	minor groove reading motif; other site
595495006616	helix-hairpin-helix signature motif; other site
595495006617	substrate binding pocket [chemical binding]; other site
595495006618	active site
595495006619	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
595495006620	electron transport complex RsxE subunit; Provisional; Region: PRK12405
595495006621	electron transport complex protein RnfG; Validated; Region: PRK01908
595495006622	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
595495006623	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
595495006624	SLBB domain; Region: SLBB; pfam10531
595495006625	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
595495006626	electron transport complex protein RnfB; Provisional; Region: PRK05113
595495006627	Putative Fe-S cluster; Region: FeS; pfam04060
595495006628	4Fe-4S binding domain; Region: Fer4; pfam00037
595495006629	electron transport complex protein RsxA; Provisional; Region: PRK05151
595495006630	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
595495006631	oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391
595495006632	putative oxidoreductase; Provisional; Region: PRK11579
595495006633	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
595495006634	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
595495006635	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
595495006636	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
595495006637	active site
595495006638	purine riboside binding site [chemical binding]; other site
595495006639	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
595495006640	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
595495006641	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495006642	homodimer interface [polypeptide binding]; other site
595495006643	catalytic residue [active]
595495006644	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
595495006645	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
595495006646	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
595495006647	active site turn [active]
595495006648	phosphorylation site [posttranslational modification]
595495006649	DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014
595495006650	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
595495006651	DNA binding site [nucleotide binding]
595495006652	domain linker motif; other site
595495006653	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
595495006654	putative dimerization interface [polypeptide binding]; other site
595495006655	putative ligand binding site [chemical binding]; other site
595495006656	7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113
595495006657	7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365
595495006658	NAD binding site [chemical binding]; other site
595495006659	substrate binding site [chemical binding]; other site
595495006660	homotetramer interface [polypeptide binding]; other site
595495006661	homodimer interface [polypeptide binding]; other site
595495006662	active site
595495006663	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
595495006664	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
595495006665	beta-D-glucuronidase; Provisional; Region: PRK10150
595495006666	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
595495006667	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
595495006668	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
595495006669	glucuronide transporter; Provisional; Region: PRK09848
595495006670	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
595495006671	putative outer membrane porin protein; Provisional; Region: PRK11379
595495006672	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
595495006673	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
595495006674	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
595495006675	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
595495006676	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
595495006677	fumarate hydratase; Provisional; Region: PRK15389
595495006678	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
595495006679	Fumarase C-terminus; Region: Fumerase_C; pfam05683
595495006680	fumarate hydratase; Reviewed; Region: fumC; PRK00485
595495006681	Class II fumarases; Region: Fumarase_classII; cd01362
595495006682	active site
595495006683	tetramer interface [polypeptide binding]; other site
595495006684	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
595495006685	sensor protein RstB; Provisional; Region: PRK10604
595495006686	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
595495006687	dimerization interface [polypeptide binding]; other site
595495006688	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
595495006689	dimer interface [polypeptide binding]; other site
595495006690	phosphorylation site [posttranslational modification]
595495006691	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495006692	ATP binding site [chemical binding]; other site
595495006693	Mg2+ binding site [ion binding]; other site
595495006694	G-X-G motif; other site
595495006695	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
595495006696	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495006697	active site
595495006698	phosphorylation site [posttranslational modification]
595495006699	intermolecular recognition site; other site
595495006700	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
595495006701	DNA binding site [nucleotide binding]
595495006702	GlpM protein; Region: GlpM; pfam06942
595495006703	dihydromonapterin reductase; Provisional; Region: PRK06483
595495006704	pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357
595495006705	NADP binding site [chemical binding]; other site
595495006706	substrate binding pocket [chemical binding]; other site
595495006707	active site
595495006708	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
595495006709	Spore germination protein; Region: Spore_permease; cl17796
595495006710	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
595495006711	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
595495006712	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
595495006713	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
595495006714	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
595495006715	ligand binding site [chemical binding]; other site
595495006716	homodimer interface [polypeptide binding]; other site
595495006717	NAD(P) binding site [chemical binding]; other site
595495006718	trimer interface B [polypeptide binding]; other site
595495006719	trimer interface A [polypeptide binding]; other site
595495006720	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
595495006721	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
595495006722	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
595495006723	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287
595495006724	Domain of unknown function DUF20; Region: UPF0118; pfam01594
595495006725	multidrug efflux system protein MdtJ; Provisional; Region: PRK10452
595495006726	multidrug efflux system protein MdtI; Provisional; Region: PRK10650
595495006727	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
595495006728	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
595495006729	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495006730	putative substrate translocation pore; other site
595495006731	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
595495006732	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495006733	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
595495006734	dimerization interface [polypeptide binding]; other site
595495006735	substrate binding pocket [chemical binding]; other site
595495006736	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
595495006737	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
595495006738	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
595495006739	nucleotide binding site [chemical binding]; other site
595495006740	putative dithiobiotin synthetase; Provisional; Region: PRK12374
595495006741	AAA domain; Region: AAA_26; pfam13500
595495006742	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
595495006743	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
595495006744	Cl- selectivity filter; other site
595495006745	Cl- binding residues [ion binding]; other site
595495006746	pore gating glutamate residue; other site
595495006747	dimer interface [polypeptide binding]; other site
595495006748	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
595495006749	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
595495006750	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
595495006751	4Fe-4S binding domain; Region: Fer4; cl02805
595495006752	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
595495006753	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
595495006754	putative [Fe4-S4] binding site [ion binding]; other site
595495006755	putative molybdopterin cofactor binding site [chemical binding]; other site
595495006756	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
595495006757	putative molybdopterin cofactor binding site; other site
595495006758	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
595495006759	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
595495006760	putative [Fe4-S4] binding site [ion binding]; other site
595495006761	putative molybdopterin cofactor binding site [chemical binding]; other site
595495006762	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
595495006763	putative molybdopterin cofactor binding site; other site
595495006764	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
595495006765	Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788
595495006766	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
595495006767	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
595495006768	Coenzyme A binding pocket [chemical binding]; other site
595495006769	hypothetical protein; Provisional; Region: PRK13659
595495006770	hypothetical protein; Provisional; Region: PRK02237
595495006771	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
595495006772	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
595495006773	putative active site pocket [active]
595495006774	putative metal binding site [ion binding]; other site
595495006775	putative oxidoreductase; Provisional; Region: PRK10083
595495006776	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
595495006777	putative NAD(P) binding site [chemical binding]; other site
595495006778	catalytic Zn binding site [ion binding]; other site
595495006779	structural Zn binding site [ion binding]; other site
595495006780	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
595495006781	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
595495006782	phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191
595495006783	Int/Topo IB signature motif; other site
595495006784	Putative excisionase (DUF1233); Region: DUF1233; pfam06806
595495006785	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
595495006786	active site
595495006787	catalytic site [active]
595495006788	substrate binding site [chemical binding]; other site
595495006789	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
595495006790	DicB protein; Region: DicB; pfam05358
595495006791	Protein of unknown function (DUF1391); Region: DUF1391; pfam07151
595495006792	transcriptional repressor DicA; Reviewed; Region: PRK09706
595495006793	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
595495006794	non-specific DNA binding site [nucleotide binding]; other site
595495006795	salt bridge; other site
595495006796	sequence-specific DNA binding site [nucleotide binding]; other site
595495006797	DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744
595495006798	Protein of unknown function (DUF1019); Region: DUF1019; pfam06254
595495006799	primosomal protein DnaI; Provisional; Region: PRK02854
595495006800	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
595495006801	Homeodomain-like domain; Region: HTH_23; pfam13384
595495006802	Winged helix-turn helix; Region: HTH_29; pfam13551
595495006803	Homeodomain-like domain; Region: HTH_32; pfam13565
595495006804	Integrase core domain; Region: rve; pfam00665
595495006805	Integrase core domain; Region: rve_3; cl15866
595495006806	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
595495006807	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
595495006808	Protein of unknown function (DUF968); Region: DUF968; pfam06147
595495006809	Antitermination protein; Region: Antiterm; pfam03589
595495006810	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
595495006811	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
595495006812	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
595495006813	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
595495006814	DNA-binding site [nucleotide binding]; DNA binding site
595495006815	RNA-binding motif; other site
595495006816	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
595495006817	DNA-binding site [nucleotide binding]; DNA binding site
595495006818	RNA-binding motif; other site
595495006819	Lysis protein S; Region: Lysis_S; pfam04971
595495006820	Protein of unknown function (DUF1327); Region: DUF1327; pfam07041
595495006821	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
595495006822	catalytic residues [active]
595495006823	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
595495006824	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
595495006825	DNA-binding site [nucleotide binding]; DNA binding site
595495006826	RNA-binding motif; other site
595495006827	GnsA/GnsB family; Region: GnsAB; pfam08178
595495006828	Protein of unknown function (DUF1398); Region: DUF1398; pfam07166
595495006829	Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471
595495006830	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
595495006831	gpW; Region: gpW; pfam02831
595495006832	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
595495006833	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
595495006834	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
595495006835	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
595495006836	tandem repeat interface [polypeptide binding]; other site
595495006837	oligomer interface [polypeptide binding]; other site
595495006838	active site residues [active]
595495006839	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
595495006840	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
595495006841	DNA packaging protein FI; Region: Packaging_FI; pfam14000
595495006842	Phage Head-Tail Attachment; Region: Phage_attach; pfam05354
595495006843	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
595495006844	Phage minor tail protein U; Region: Phage_tail_U; pfam06141
595495006845	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
595495006846	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
595495006847	phage minor tail protein G; Region: phage_lambda_G; TIGR01674
595495006848	Minor tail protein T; Region: Phage_tail_T; pfam06223
595495006849	Phage-related minor tail protein [Function unknown]; Region: COG5281
595495006850	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
595495006851	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
595495006852	Phage-related protein [Function unknown]; Region: COG4718
595495006853	Phage-related protein [Function unknown]; Region: gp18; COG4672
595495006854	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
595495006855	MPN+ (JAMM) motif; other site
595495006856	Zinc-binding site [ion binding]; other site
595495006857	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
595495006858	NlpC/P60 family; Region: NLPC_P60; cl17555
595495006859	Phage-related protein, tail component [Function unknown]; Region: COG4723
595495006860	Phage-related protein, tail component [Function unknown]; Region: COG4733
595495006861	Putative phage tail protein; Region: Phage-tail_3; pfam13550
595495006862	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
595495006863	Interdomain contacts; other site
595495006864	Cytokine receptor motif; other site
595495006865	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
595495006866	Fibronectin type III protein; Region: DUF3672; pfam12421
595495006867	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
595495006868	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
595495006869	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
595495006870	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
595495006871	Phage Tail Collar Domain; Region: Collar; pfam07484
595495006872	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
595495006873	multiple promoter invertase; Provisional; Region: mpi; PRK13413
595495006874	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
595495006875	catalytic residues [active]
595495006876	catalytic nucleophile [active]
595495006877	Presynaptic Site I dimer interface [polypeptide binding]; other site
595495006878	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
595495006879	Synaptic Flat tetramer interface [polypeptide binding]; other site
595495006880	Synaptic Site I dimer interface [polypeptide binding]; other site
595495006881	DNA binding site [nucleotide binding]
595495006882	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
595495006883	DNA-binding interface [nucleotide binding]; DNA binding site
595495006884	metabolite-proton symporter; Region: 2A0106; TIGR00883
595495006885	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495006886	putative substrate translocation pore; other site
595495006887	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
595495006888	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
595495006889	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
595495006890	putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318
595495006891	Transcriptional regulators [Transcription]; Region: GntR; COG1802
595495006892	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495006893	DNA-binding site [nucleotide binding]; DNA binding site
595495006894	FCD domain; Region: FCD; pfam07729
595495006895	malonic semialdehyde reductase; Provisional; Region: PRK10538
595495006896	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
595495006897	putative NAD(P) binding site [chemical binding]; other site
595495006898	homodimer interface [polypeptide binding]; other site
595495006899	homotetramer interface [polypeptide binding]; other site
595495006900	active site
595495006901	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
595495006902	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
595495006903	active site
595495006904	Zn binding site [ion binding]; other site
595495006905	hypothetical protein; Validated; Region: PRK03657
595495006906	hypothetical protein; Provisional; Region: PRK10053
595495006907	diguanylate cyclase; Provisional; Region: PRK09894
595495006908	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
595495006909	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
595495006910	metal binding site [ion binding]; metal-binding site
595495006911	active site
595495006912	I-site; other site
595495006913	putative transporter; Provisional; Region: PRK10054
595495006914	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495006915	putative substrate translocation pore; other site
595495006916	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
595495006917	EamA-like transporter family; Region: EamA; pfam00892
595495006918	EamA-like transporter family; Region: EamA; pfam00892
595495006919	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
595495006920	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495006921	DNA-binding site [nucleotide binding]; DNA binding site
595495006922	UTRA domain; Region: UTRA; pfam07702
595495006923	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
595495006924	active site
595495006925	P-loop; other site
595495006926	phosphorylation site [posttranslational modification]
595495006927	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
595495006928	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
595495006929	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
595495006930	active site
595495006931	methionine cluster; other site
595495006932	phosphorylation site [posttranslational modification]
595495006933	metal binding site [ion binding]; metal-binding site
595495006934	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
595495006935	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
595495006936	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
595495006937	trimer interface; other site
595495006938	sugar binding site [chemical binding]; other site
595495006939	6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589
595495006940	beta-galactosidase; Region: BGL; TIGR03356
595495006941	hypothetical protein; Provisional; Region: PRK10106
595495006942	DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511
595495006943	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495006944	DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512
595495006945	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
595495006946	inner membrane protein; Provisional; Region: PRK10995
595495006947	putative arabinose transporter; Provisional; Region: PRK03545
595495006948	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495006949	putative substrate translocation pore; other site
595495006950	Transcriptional regulator [Transcription]; Region: LysR; COG0583
595495006951	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495006952	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
595495006953	putative dimerization interface [polypeptide binding]; other site
595495006954	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
595495006955	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
595495006956	NAD(P) binding site [chemical binding]; other site
595495006957	catalytic residues [active]
595495006958	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
595495006959	glutaminase; Provisional; Region: PRK00971
595495006960	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
595495006961	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
595495006962	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
595495006963	metal binding site [ion binding]; metal-binding site
595495006964	active site
595495006965	I-site; other site
595495006966	altronate oxidoreductase; Provisional; Region: PRK03643
595495006967	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
595495006968	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
595495006969	Predicted membrane protein [Function unknown]; Region: COG3781
595495006970	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
595495006971	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495006972	S-adenosylmethionine binding site [chemical binding]; other site
595495006973	autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486
595495006974	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
595495006975	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
595495006976	putative active site; other site
595495006977	catalytic residue [active]
595495006978	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
595495006979	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
595495006980	ligand binding site [chemical binding]; other site
595495006981	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
595495006982	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
595495006983	TM-ABC transporter signature motif; other site
595495006984	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
595495006985	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
595495006986	TM-ABC transporter signature motif; other site
595495006987	autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439
595495006988	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
595495006989	Walker A/P-loop; other site
595495006990	ATP binding site [chemical binding]; other site
595495006991	Q-loop/lid; other site
595495006992	ABC transporter signature motif; other site
595495006993	Walker B; other site
595495006994	D-loop; other site
595495006995	H-loop/switch region; other site
595495006996	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
595495006997	transcriptional regulator LsrR; Provisional; Region: PRK15418
595495006998	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
595495006999	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
595495007000	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
595495007001	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
595495007002	putative N- and C-terminal domain interface [polypeptide binding]; other site
595495007003	putative active site [active]
595495007004	putative MgATP binding site [chemical binding]; other site
595495007005	catalytic site [active]
595495007006	metal binding site [ion binding]; metal-binding site
595495007007	putative carbohydrate binding site [chemical binding]; other site
595495007008	putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849
595495007009	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
595495007010	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
595495007011	Autotransporter beta-domain; Region: Autotransporter; pfam03797
595495007012	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
595495007013	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
595495007014	non-specific DNA binding site [nucleotide binding]; other site
595495007015	salt bridge; other site
595495007016	sequence-specific DNA binding site [nucleotide binding]; other site
595495007017	HipA N-terminal domain; Region: Couple_hipA; pfam13657
595495007018	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
595495007019	HipA-like N-terminal domain; Region: HipA_N; pfam07805
595495007020	HipA-like C-terminal domain; Region: HipA_C; pfam07804
595495007021	Fimbrial protein; Region: Fimbrial; cl01416
595495007022	fimbrial chaperone protein FimC; Provisional; Region: PRK15195
595495007023	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
595495007024	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
595495007025	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
595495007026	PapC N-terminal domain; Region: PapC_N; pfam13954
595495007027	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
595495007028	PapC C-terminal domain; Region: PapC_C; pfam13953
595495007029	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
595495007030	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
595495007031	Mannose binding  domain of FimH and related proteins; Region: FimH_man-bind; cd10466
595495007032	mannosyl binding site [chemical binding]; other site
595495007033	Fimbrial protein; Region: Fimbrial; pfam00419
595495007034	putative oxidoreductase; Provisional; Region: PRK09939
595495007035	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
595495007036	putative molybdopterin cofactor binding site [chemical binding]; other site
595495007037	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
595495007038	putative molybdopterin cofactor binding site; other site
595495007039	transcriptional regulator YdeO; Provisional; Region: PRK09940
595495007040	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495007041	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
595495007042	Sulfatase; Region: Sulfatase; pfam00884
595495007043	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
595495007044	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
595495007045	FeS/SAM binding site; other site
595495007046	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
595495007047	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
595495007048	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
595495007049	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
595495007050	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
595495007051	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
595495007052	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
595495007053	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
595495007054	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
595495007055	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
595495007056	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
595495007057	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
595495007058	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495007059	catalytic residue [active]
595495007060	glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910
595495007061	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
595495007062	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
595495007063	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
595495007064	heme-binding site [chemical binding]; other site
595495007065	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
595495007066	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
595495007067	metal binding site [ion binding]; metal-binding site
595495007068	active site
595495007069	I-site; other site
595495007070	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
595495007071	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
595495007072	putative active site [active]
595495007073	heme pocket [chemical binding]; other site
595495007074	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
595495007075	putative active site [active]
595495007076	heme pocket [chemical binding]; other site
595495007077	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
595495007078	metal binding site [ion binding]; metal-binding site
595495007079	active site
595495007080	I-site; other site
595495007081	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
595495007082	D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178
595495007083	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
595495007084	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
595495007085	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
595495007086	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495007087	dimer interface [polypeptide binding]; other site
595495007088	conserved gate region; other site
595495007089	putative PBP binding loops; other site
595495007090	ABC-ATPase subunit interface; other site
595495007091	D-ala-D-ala transporter subunit; Provisional; Region: PRK09881
595495007092	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
595495007093	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495007094	dimer interface [polypeptide binding]; other site
595495007095	conserved gate region; other site
595495007096	putative PBP binding loops; other site
595495007097	ABC-ATPase subunit interface; other site
595495007098	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
595495007099	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
595495007100	Walker A/P-loop; other site
595495007101	ATP binding site [chemical binding]; other site
595495007102	Q-loop/lid; other site
595495007103	ABC transporter signature motif; other site
595495007104	Walker B; other site
595495007105	D-loop; other site
595495007106	H-loop/switch region; other site
595495007107	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
595495007108	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
595495007109	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
595495007110	Walker A/P-loop; other site
595495007111	ATP binding site [chemical binding]; other site
595495007112	Q-loop/lid; other site
595495007113	ABC transporter signature motif; other site
595495007114	Walker B; other site
595495007115	D-loop; other site
595495007116	H-loop/switch region; other site
595495007117	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
595495007118	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
595495007119	Putative biofilm-dependent modulation protein; Region: BDM; pfam10684
595495007120	30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057
595495007121	malate dehydrogenase; Provisional; Region: PRK13529
595495007122	Malic enzyme, N-terminal domain; Region: malic; pfam00390
595495007123	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
595495007124	NAD(P) binding site [chemical binding]; other site
595495007125	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
595495007126	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
595495007127	NAD binding site [chemical binding]; other site
595495007128	substrate binding site [chemical binding]; other site
595495007129	catalytic Zn binding site [ion binding]; other site
595495007130	tetramer interface [polypeptide binding]; other site
595495007131	structural Zn binding site [ion binding]; other site
595495007132	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
595495007133	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
595495007134	non-specific DNA binding site [nucleotide binding]; other site
595495007135	salt bridge; other site
595495007136	sequence-specific DNA binding site [nucleotide binding]; other site
595495007137	formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179
595495007138	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
595495007139	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
595495007140	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
595495007141	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
595495007142	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
595495007143	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
595495007144	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
595495007145	molybdopterin cofactor binding site; other site
595495007146	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
595495007147	aromatic amino acid exporter; Provisional; Region: PRK11689
595495007148	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
595495007149	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
595495007150	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
595495007151	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
595495007152	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
595495007153	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
595495007154	[4Fe-4S] binding site [ion binding]; other site
595495007155	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
595495007156	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
595495007157	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
595495007158	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
595495007159	molybdopterin cofactor binding site; other site
595495007160	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
595495007161	nitrate reductase 2 subunit delta; Provisional; Region: PRK15054
595495007162	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
595495007163	hypothetical protein; Provisional; Region: PRK10281
595495007164	N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047
595495007165	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
595495007166	4-oxalocrotonate tautomerase; Provisional; Region: PRK01271
595495007167	active site 1 [active]
595495007168	dimer interface [polypeptide binding]; other site
595495007169	hexamer interface [polypeptide binding]; other site
595495007170	active site 2 [active]
595495007171	PAAR motif; Region: PAAR_motif; cl15808
595495007172	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
595495007173	RHS Repeat; Region: RHS_repeat; pfam05593
595495007174	RHS Repeat; Region: RHS_repeat; pfam05593
595495007175	RHS Repeat; Region: RHS_repeat; pfam05593
595495007176	RHS Repeat; Region: RHS_repeat; pfam05593
595495007177	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
595495007178	RHS Repeat; Region: RHS_repeat; pfam05593
595495007179	RHS Repeat; Region: RHS_repeat; pfam05593
595495007180	RHS protein; Region: RHS; pfam03527
595495007181	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
595495007182	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
595495007183	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
595495007184	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
595495007185	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
595495007186	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
595495007187	C-terminal domain interface [polypeptide binding]; other site
595495007188	GSH binding site (G-site) [chemical binding]; other site
595495007189	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
595495007190	dimer interface [polypeptide binding]; other site
595495007191	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
595495007192	dimer interface [polypeptide binding]; other site
595495007193	N-terminal domain interface [polypeptide binding]; other site
595495007194	substrate binding pocket (H-site) [chemical binding]; other site
595495007195	L-asparagine permease; Provisional; Region: PRK15049
595495007196	PQQ-like domain; Region: PQQ_2; pfam13360
595495007197	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
595495007198	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
595495007199	N-terminal plug; other site
595495007200	ligand-binding site [chemical binding]; other site
595495007201	colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414
595495007202	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495007203	DNA-binding site [nucleotide binding]; DNA binding site
595495007204	FCD domain; Region: FCD; pfam07729
595495007205	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
595495007206	Prostaglandin dehydrogenases; Region: PGDH; cd05288
595495007207	NAD(P) binding site [chemical binding]; other site
595495007208	substrate binding site [chemical binding]; other site
595495007209	dimer interface [polypeptide binding]; other site
595495007210	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
595495007211	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
595495007212	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
595495007213	Protein of unknown function (DUF2526); Region: DUF2526; pfam10735
595495007214	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
595495007215	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
595495007216	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
595495007217	tetrameric interface [polypeptide binding]; other site
595495007218	NAD binding site [chemical binding]; other site
595495007219	catalytic residues [active]
595495007220	substrate binding site [chemical binding]; other site
595495007221	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
595495007222	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495007223	ABC-ATPase subunit interface; other site
595495007224	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495007225	dimer interface [polypeptide binding]; other site
595495007226	conserved gate region; other site
595495007227	putative PBP binding loops; other site
595495007228	ABC-ATPase subunit interface; other site
595495007229	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
595495007230	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495007231	Walker A/P-loop; other site
595495007232	ATP binding site [chemical binding]; other site
595495007233	Q-loop/lid; other site
595495007234	ABC transporter signature motif; other site
595495007235	Walker B; other site
595495007236	D-loop; other site
595495007237	H-loop/switch region; other site
595495007238	TOBE domain; Region: TOBE_2; pfam08402
595495007239	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
595495007240	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
595495007241	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
595495007242	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495007243	DNA-binding site [nucleotide binding]; DNA binding site
595495007244	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
595495007245	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495007246	homodimer interface [polypeptide binding]; other site
595495007247	catalytic residue [active]
595495007248	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
595495007249	Helix-turn-helix; Region: HTH_3; pfam01381
595495007250	YcfA-like protein; Region: YcfA; pfam07927
595495007251	Protein of unknown function (DUF2554); Region: DUF2554; pfam10829
595495007252	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
595495007253	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
595495007254	Peptidase family U32; Region: Peptidase_U32; pfam01136
595495007255	Collagenase; Region: DUF3656; pfam12392
595495007256	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
595495007257	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
595495007258	non-specific DNA binding site [nucleotide binding]; other site
595495007259	salt bridge; other site
595495007260	sequence-specific DNA binding site [nucleotide binding]; other site
595495007261	Cupin domain; Region: Cupin_2; pfam07883
595495007262	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
595495007263	benzoate transporter; Region: benE; TIGR00843
595495007264	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
595495007265	Probable transposase; Region: OrfB_IS605; pfam01385
595495007266	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
595495007267	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
595495007268	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
595495007269	tellurite resistance protein TehB; Provisional; Region: PRK11207
595495007270	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495007271	S-adenosylmethionine binding site [chemical binding]; other site
595495007272	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
595495007273	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
595495007274	gating phenylalanine in ion channel; other site
595495007275	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
595495007276	putative trimer interface [polypeptide binding]; other site
595495007277	putative CoA binding site [chemical binding]; other site
595495007278	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208
595495007279	putative trimer interface [polypeptide binding]; other site
595495007280	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
595495007281	putative CoA binding site [chemical binding]; other site
595495007282	putative trimer interface [polypeptide binding]; other site
595495007283	putative CoA binding site [chemical binding]; other site
595495007284	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
595495007285	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
595495007286	Coenzyme A binding pocket [chemical binding]; other site
595495007287	hypothetical protein; Provisional; Region: PRK11415
595495007288	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
595495007289	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
595495007290	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
595495007291	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
595495007292	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
595495007293	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495007294	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
595495007295	dimerization interface [polypeptide binding]; other site
595495007296	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
595495007297	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
595495007298	dimer interface [polypeptide binding]; other site
595495007299	ligand binding site [chemical binding]; other site
595495007300	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
595495007301	dimerization interface [polypeptide binding]; other site
595495007302	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
595495007303	dimer interface [polypeptide binding]; other site
595495007304	putative CheW interface [polypeptide binding]; other site
595495007305	hypothetical protein; Provisional; Region: PRK10040
595495007306	cytochrome b561; Provisional; Region: PRK11513
595495007307	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
595495007308	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
595495007309	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
595495007310	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
595495007311	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
595495007312	NAD binding site [chemical binding]; other site
595495007313	catalytic residues [active]
595495007314	substrate binding site [chemical binding]; other site
595495007315	Uncharacterized conserved protein [Function unknown]; Region: COG1434
595495007316	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
595495007317	putative active site [active]
595495007318	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
595495007319	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
595495007320	ATP binding site [chemical binding]; other site
595495007321	putative Mg++ binding site [ion binding]; other site
595495007322	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
595495007323	nucleotide binding region [chemical binding]; other site
595495007324	ATP-binding site [chemical binding]; other site
595495007325	Helicase associated domain (HA2); Region: HA2; pfam04408
595495007326	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
595495007327	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
595495007328	azoreductase; Reviewed; Region: PRK00170
595495007329	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
595495007330	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
595495007331	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
595495007332	active site
595495007333	Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cd00127
595495007334	active site
595495007335	catalytic residues [active]
595495007336	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
595495007337	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
595495007338	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495007339	S-adenosylmethionine binding site [chemical binding]; other site
595495007340	Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589
595495007341	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
595495007342	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
595495007343	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
595495007344	Protein of unknown function (DUF2773); Region: DUF2773; pfam10971
595495007345	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
595495007346	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
595495007347	active site
595495007348	catalytic tetrad [active]
595495007349	phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287
595495007350	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
595495007351	putative trimer interface [polypeptide binding]; other site
595495007352	putative metal binding site [ion binding]; other site
595495007353	PaaX-like protein; Region: PaaX; pfam07848
595495007354	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
595495007355	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
595495007356	Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913
595495007357	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
595495007358	active site
595495007359	AMP binding site [chemical binding]; other site
595495007360	homodimer interface [polypeptide binding]; other site
595495007361	acyl-activating enzyme (AAE) consensus motif; other site
595495007362	CoA binding site [chemical binding]; other site
595495007363	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
595495007364	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
595495007365	dimer interface [polypeptide binding]; other site
595495007366	active site
595495007367	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
595495007368	CoenzymeA binding site [chemical binding]; other site
595495007369	subunit interaction site [polypeptide binding]; other site
595495007370	PHB binding site; other site
595495007371	3-hydroxyacyl-CoA dehydrogenase PaaC; Region: PaaC-3OHAcCoADH; TIGR02279
595495007372	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
595495007373	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
595495007374	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
595495007375	enoyl-CoA hydratase; Provisional; Region: PRK08140
595495007376	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
595495007377	substrate binding site [chemical binding]; other site
595495007378	oxyanion hole (OAH) forming residues; other site
595495007379	trimer interface [polypeptide binding]; other site
595495007380	enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674
595495007381	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
595495007382	substrate binding site [chemical binding]; other site
595495007383	oxyanion hole (OAH) forming residues; other site
595495007384	trimer interface [polypeptide binding]; other site
595495007385	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
595495007386	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
595495007387	FAD binding pocket [chemical binding]; other site
595495007388	FAD binding motif [chemical binding]; other site
595495007389	phosphate binding motif [ion binding]; other site
595495007390	beta-alpha-beta structure motif; other site
595495007391	NAD(p) ribose binding residues [chemical binding]; other site
595495007392	NAD binding pocket [chemical binding]; other site
595495007393	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
595495007394	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
595495007395	catalytic loop [active]
595495007396	iron binding site [ion binding]; other site
595495007397	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
595495007398	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
595495007399	phenylacetate-CoA oxygenase, PaaI subunit; Region: PA_CoA_Oxy3; TIGR02158
595495007400	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
595495007401	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
595495007402	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
595495007403	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
595495007404	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
595495007405	substrate binding site [chemical binding]; other site
595495007406	dimer interface [polypeptide binding]; other site
595495007407	NADP binding site [chemical binding]; other site
595495007408	catalytic residues [active]
595495007409	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
595495007410	substrate binding site [chemical binding]; other site
595495007411	tyramine oxidase; Provisional; Region: tynA; PRK14696
595495007412	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
595495007413	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
595495007414	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
595495007415	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
595495007416	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
595495007417	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
595495007418	NAD(P) binding site [chemical binding]; other site
595495007419	catalytic residues [active]
595495007420	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
595495007421	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495007422	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784
595495007423	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
595495007424	hypothetical protein; Provisional; Region: PRK10695
595495007425	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
595495007426	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
595495007427	putative ligand binding site [chemical binding]; other site
595495007428	putative NAD binding site [chemical binding]; other site
595495007429	catalytic site [active]
595495007430	heat-inducible protein; Provisional; Region: PRK10449
595495007431	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
595495007432	Domain of unknown function (DUF333); Region: DUF333; pfam03891
595495007433	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
595495007434	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
595495007435	dimer interface [polypeptide binding]; other site
595495007436	PYR/PP interface [polypeptide binding]; other site
595495007437	TPP binding site [chemical binding]; other site
595495007438	substrate binding site [chemical binding]; other site
595495007439	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
595495007440	Domain of unknown function; Region: EKR; smart00890
595495007441	4Fe-4S binding domain; Region: Fer4_6; pfam12837
595495007442	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
595495007443	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
595495007444	TPP-binding site [chemical binding]; other site
595495007445	dimer interface [polypeptide binding]; other site
595495007446	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
595495007447	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
595495007448	trimer interface [polypeptide binding]; other site
595495007449	eyelet of channel; other site
595495007450	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
595495007451	Ligand Binding Site [chemical binding]; other site
595495007452	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
595495007453	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
595495007454	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
595495007455	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
595495007456	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
595495007457	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
595495007458	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
595495007459	N-acetyl-D-glucosamine binding site [chemical binding]; other site
595495007460	catalytic residue [active]
595495007461	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
595495007462	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
595495007463	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
595495007464	Terminase-like family; Region: Terminase_6; pfam03237
595495007465	large terminase protein; Provisional; Region: 17; PHA02533
595495007466	Terminase small subunit; Region: Terminase_2; cl01513
595495007467	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
595495007468	ParB-like nuclease domain; Region: ParBc; pfam02195
595495007469	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
595495007470	Protein of unknown function (DUF754); Region: DUF754; pfam05449
595495007471	Protein of unknown function (DUF1133); Region: DUF1133; pfam06576
595495007472	Protein of unknown function (DUF1364); Region: DUF1364; pfam07102
595495007473	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
595495007474	Hok/gef family; Region: HOK_GEF; pfam01848
595495007475	Uncharacterized conserved protein [Function unknown]; Region: COG4938
595495007476	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
595495007477	Protein of unknown function DUF262; Region: DUF262; pfam03235
595495007478	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
595495007479	Protein of unknown function (DUF1627); Region: DUF1627; pfam07789
595495007480	putative replication protein; Provisional; Region: PRK12377
595495007481	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495007482	Walker A motif; other site
595495007483	ATP binding site [chemical binding]; other site
595495007484	Walker B motif; other site
595495007485	arginine finger; other site
595495007486	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3756
595495007487	primosomal protein DnaI; Provisional; Region: PRK02854
595495007488	Protein of unknown function (DUF1019); Region: DUF1019; pfam06254
595495007489	Helix-turn-helix domain; Region: HTH_17; cl17695
595495007490	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
595495007491	non-specific DNA binding site [nucleotide binding]; other site
595495007492	salt bridge; other site
595495007493	transcriptional repressor DicA; Reviewed; Region: PRK09706
595495007494	sequence-specific DNA binding site [nucleotide binding]; other site
595495007495	Protein of unknown function (DUF1391); Region: DUF1391; pfam07151
595495007496	FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354
595495007497	hypothetical protein; Reviewed; Region: PRK09790
595495007498	exonuclease VIII; Reviewed; Region: PRK09709
595495007499	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
595495007500	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
595495007501	recombination and repair protein RecT; Reviewed; Region: recT; PRK09846
595495007502	restriction alleviation and modification protein; Reviewed; Region: lar; PRK09710
595495007503	hypothetical protein; Provisional; Region: PRK09750
595495007504	Putative excisionase (DUF1233); Region: DUF1233; pfam06806
595495007505	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
595495007506	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
595495007507	phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191
595495007508	Int/Topo IB signature motif; other site
595495007509	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
595495007510	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
595495007511	Ligand Binding Site [chemical binding]; other site
595495007512	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
595495007513	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
595495007514	ATP binding site [chemical binding]; other site
595495007515	Mg++ binding site [ion binding]; other site
595495007516	motif III; other site
595495007517	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
595495007518	nucleotide binding region [chemical binding]; other site
595495007519	ATP-binding site [chemical binding]; other site
595495007520	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
595495007521	putative RNA binding site [nucleotide binding]; other site
595495007522	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
595495007523	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
595495007524	Cl binding site [ion binding]; other site
595495007525	oligomer interface [polypeptide binding]; other site
595495007526	PAS domain S-box; Region: sensory_box; TIGR00229
595495007527	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
595495007528	putative active site [active]
595495007529	heme pocket [chemical binding]; other site
595495007530	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
595495007531	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
595495007532	metal binding site [ion binding]; metal-binding site
595495007533	active site
595495007534	I-site; other site
595495007535	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
595495007536	Smr domain; Region: Smr; pfam01713
595495007537	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
595495007538	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495007539	The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418
595495007540	putative substrate binding pocket [chemical binding]; other site
595495007541	putative dimerization interface [polypeptide binding]; other site
595495007542	M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665
595495007543	amidohydrolase; Region: amidohydrolases; TIGR01891
595495007544	putative metal binding site [ion binding]; other site
595495007545	dimer interface [polypeptide binding]; other site
595495007546	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
595495007547	amidohydrolase; Region: amidohydrolases; TIGR01891
595495007548	putative metal binding site [ion binding]; other site
595495007549	putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339
595495007550	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
595495007551	O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286
595495007552	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
595495007553	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
595495007554	DNA binding site [nucleotide binding]
595495007555	active site
595495007556	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
595495007557	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
595495007558	ligand binding site [chemical binding]; other site
595495007559	flexible hinge region; other site
595495007560	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
595495007561	putative switch regulator; other site
595495007562	non-specific DNA interactions [nucleotide binding]; other site
595495007563	DNA binding site [nucleotide binding]
595495007564	sequence specific DNA binding site [nucleotide binding]; other site
595495007565	putative cAMP binding site [chemical binding]; other site
595495007566	universal stress protein UspE; Provisional; Region: PRK11175
595495007567	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
595495007568	Ligand Binding Site [chemical binding]; other site
595495007569	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
595495007570	Ligand Binding Site [chemical binding]; other site
595495007571	Protein of unknown function (DUF2534); Region: DUF2534; pfam10749
595495007572	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
595495007573	Mechanosensitive ion channel; Region: MS_channel; pfam00924
595495007574	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
595495007575	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
595495007576	peptide binding site [polypeptide binding]; other site
595495007577	Transcriptional regulator [Transcription]; Region: LysR; COG0583
595495007578	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495007579	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
595495007580	putative effector binding pocket; other site
595495007581	putative dimerization interface [polypeptide binding]; other site
595495007582	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
595495007583	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
595495007584	atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267
595495007585	NADH(P)-binding; Region: NAD_binding_10; pfam13460
595495007586	putative NAD(P) binding site [chemical binding]; other site
595495007587	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
595495007588	Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904
595495007589	putative active site [active]
595495007590	Zn binding site [ion binding]; other site
595495007591	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
595495007592	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
595495007593	active site
595495007594	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
595495007595	dimer interface [polypeptide binding]; other site
595495007596	catalytic triad [active]
595495007597	peroxidatic and resolving cysteines [active]
595495007598	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
595495007599	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
595495007600	putative aromatic amino acid binding site; other site
595495007601	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495007602	Walker A motif; other site
595495007603	ATP binding site [chemical binding]; other site
595495007604	Walker B motif; other site
595495007605	arginine finger; other site
595495007606	Predicted membrane protein [Function unknown]; Region: COG3768
595495007607	TIGR01620 family protein; Region: hyp_HI0043
595495007608	Predicted ATPase [General function prediction only]; Region: COG3106
595495007609	Transcriptional regulators [Transcription]; Region: PurR; COG1609
595495007610	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
595495007611	DNA binding site [nucleotide binding]
595495007612	domain linker motif; other site
595495007613	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
595495007614	putative dimerization interface [polypeptide binding]; other site
595495007615	putative ligand binding site [chemical binding]; other site
595495007616	Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381
595495007617	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
595495007618	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
595495007619	Walker A/P-loop; other site
595495007620	ATP binding site [chemical binding]; other site
595495007621	Q-loop/lid; other site
595495007622	ABC transporter signature motif; other site
595495007623	Walker B; other site
595495007624	D-loop; other site
595495007625	H-loop/switch region; other site
595495007626	TOBE domain; Region: TOBE_2; pfam08402
595495007627	beta-phosphoglucomutase; Region: bPGM; TIGR01990
595495007628	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495007629	motif II; other site
595495007630	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
595495007631	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
595495007632	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
595495007633	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
595495007634	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
595495007635	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
595495007636	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
595495007637	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
595495007638	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
595495007639	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
595495007640	putative NAD(P) binding site [chemical binding]; other site
595495007641	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
595495007642	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495007643	dimer interface [polypeptide binding]; other site
595495007644	conserved gate region; other site
595495007645	putative PBP binding loops; other site
595495007646	ABC-ATPase subunit interface; other site
595495007647	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495007648	dimer interface [polypeptide binding]; other site
595495007649	conserved gate region; other site
595495007650	putative PBP binding loops; other site
595495007651	ABC-ATPase subunit interface; other site
595495007652	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
595495007653	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
595495007654	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
595495007655	sucrose phosphorylase; Provisional; Region: PRK13840
595495007656	active site
595495007657	homodimer interface [polypeptide binding]; other site
595495007658	catalytic site [active]
595495007659	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
595495007660	active site residue [active]
595495007661	peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497
595495007662	DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697
595495007663	phage shock protein C; Region: phageshock_pspC; TIGR02978
595495007664	phage shock protein B; Provisional; Region: pspB; PRK09458
595495007665	phage shock protein PspA; Provisional; Region: PRK10698
595495007666	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
595495007667	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495007668	Walker A motif; other site
595495007669	ATP binding site [chemical binding]; other site
595495007670	Walker B motif; other site
595495007671	arginine finger; other site
595495007672	4-aminobutyrate transaminase; Provisional; Region: PRK09792
595495007673	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
595495007674	inhibitor-cofactor binding pocket; inhibition site
595495007675	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495007676	catalytic residue [active]
595495007677	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
595495007678	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
595495007679	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
595495007680	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
595495007681	NAD(P) binding site [chemical binding]; other site
595495007682	catalytic residues [active]
595495007683	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
595495007684	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
595495007685	non-specific DNA binding site [nucleotide binding]; other site
595495007686	salt bridge; other site
595495007687	sequence-specific DNA binding site [nucleotide binding]; other site
595495007688	Cupin domain; Region: Cupin_2; pfam07883
595495007689	gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366
595495007690	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
595495007691	catalytic triad [active]
595495007692	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
595495007693	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
595495007694	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
595495007695	Protein of unknown function (DUF2543); Region: DUF2543; pfam10820
595495007696	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
595495007697	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
595495007698	peptide binding site [polypeptide binding]; other site
595495007699	antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110
595495007700	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495007701	dimer interface [polypeptide binding]; other site
595495007702	conserved gate region; other site
595495007703	putative PBP binding loops; other site
595495007704	ABC-ATPase subunit interface; other site
595495007705	antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111
595495007706	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
595495007707	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495007708	dimer interface [polypeptide binding]; other site
595495007709	conserved gate region; other site
595495007710	putative PBP binding loops; other site
595495007711	ABC-ATPase subunit interface; other site
595495007712	antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093
595495007713	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
595495007714	Walker A/P-loop; other site
595495007715	ATP binding site [chemical binding]; other site
595495007716	Q-loop/lid; other site
595495007717	ABC transporter signature motif; other site
595495007718	Walker B; other site
595495007719	D-loop; other site
595495007720	H-loop/switch region; other site
595495007721	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
595495007722	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
595495007723	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
595495007724	Walker A/P-loop; other site
595495007725	ATP binding site [chemical binding]; other site
595495007726	Q-loop/lid; other site
595495007727	ABC transporter signature motif; other site
595495007728	Walker B; other site
595495007729	D-loop; other site
595495007730	H-loop/switch region; other site
595495007731	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
595495007732	putative active site [active]
595495007733	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984
595495007734	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
595495007735	NAD binding site [chemical binding]; other site
595495007736	homotetramer interface [polypeptide binding]; other site
595495007737	homodimer interface [polypeptide binding]; other site
595495007738	substrate binding site [chemical binding]; other site
595495007739	active site
595495007740	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950
595495007741	Uncharacterized conserved protein [Function unknown]; Region: COG2128
595495007742	exoribonuclease II; Provisional; Region: PRK05054
595495007743	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
595495007744	RNB domain; Region: RNB; pfam00773
595495007745	S1 RNA binding domain; Region: S1; pfam00575
595495007746	RNase II stability modulator; Provisional; Region: PRK10060
595495007747	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
595495007748	putative active site [active]
595495007749	heme pocket [chemical binding]; other site
595495007750	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
595495007751	metal binding site [ion binding]; metal-binding site
595495007752	active site
595495007753	I-site; other site
595495007754	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
595495007755	hypothetical protein; Provisional; Region: PRK13658
595495007756	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
595495007757	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
595495007758	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
595495007759	lipoprotein; Provisional; Region: PRK10540
595495007760	translation initiation factor Sui1; Validated; Region: PRK06824
595495007761	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
595495007762	putative rRNA binding site [nucleotide binding]; other site
595495007763	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
595495007764	active site
595495007765	dimer interface [polypeptide binding]; other site
595495007766	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
595495007767	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
595495007768	TPR motif; other site
595495007769	binding surface
595495007770	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
595495007771	binding surface
595495007772	TPR motif; other site
595495007773	Predicted membrane protein [Function unknown]; Region: COG3771
595495007774	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
595495007775	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
595495007776	active site
595495007777	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
595495007778	dimerization interface [polypeptide binding]; other site
595495007779	active site
595495007780	aconitate hydratase; Validated; Region: PRK09277
595495007781	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
595495007782	substrate binding site [chemical binding]; other site
595495007783	ligand binding site [chemical binding]; other site
595495007784	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
595495007785	substrate binding site [chemical binding]; other site
595495007786	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
595495007787	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495007788	The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443
595495007789	substrate binding site [chemical binding]; other site
595495007790	putative dimerization interface [polypeptide binding]; other site
595495007791	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
595495007792	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
595495007793	active site
595495007794	interdomain interaction site; other site
595495007795	putative metal-binding site [ion binding]; other site
595495007796	nucleotide binding site [chemical binding]; other site
595495007797	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
595495007798	domain I; other site
595495007799	DNA binding groove [nucleotide binding]
595495007800	phosphate binding site [ion binding]; other site
595495007801	domain II; other site
595495007802	domain III; other site
595495007803	nucleotide binding site [chemical binding]; other site
595495007804	catalytic site [active]
595495007805	domain IV; other site
595495007806	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
595495007807	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
595495007808	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
595495007809	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
595495007810	hypothetical protein; Provisional; Region: PRK11037
595495007811	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
595495007812	putative inner membrane peptidase; Provisional; Region: PRK11778
595495007813	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
595495007814	tandem repeat interface [polypeptide binding]; other site
595495007815	oligomer interface [polypeptide binding]; other site
595495007816	active site residues [active]
595495007817	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
595495007818	Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340
595495007819	NADP binding site [chemical binding]; other site
595495007820	homodimer interface [polypeptide binding]; other site
595495007821	active site
595495007822	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
595495007823	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
595495007824	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
595495007825	homodimer interface [polypeptide binding]; other site
595495007826	Walker A motif; other site
595495007827	ATP binding site [chemical binding]; other site
595495007828	hydroxycobalamin binding site [chemical binding]; other site
595495007829	Walker B motif; other site
595495007830	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
595495007831	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
595495007832	RNA binding surface [nucleotide binding]; other site
595495007833	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
595495007834	probable active site [active]
595495007835	hypothetical protein; Provisional; Region: PRK11630
595495007836	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
595495007837	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
595495007838	active site
595495007839	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
595495007840	anthranilate synthase component I; Provisional; Region: PRK13564
595495007841	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
595495007842	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
595495007843	bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522
595495007844	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
595495007845	glutamine binding [chemical binding]; other site
595495007846	catalytic triad [active]
595495007847	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
595495007848	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
595495007849	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
595495007850	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
595495007851	active site
595495007852	ribulose/triose binding site [chemical binding]; other site
595495007853	phosphate binding site [ion binding]; other site
595495007854	substrate (anthranilate) binding pocket [chemical binding]; other site
595495007855	product (indole) binding pocket [chemical binding]; other site
595495007856	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
595495007857	active site
595495007858	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
595495007859	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
595495007860	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495007861	catalytic residue [active]
595495007862	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
595495007863	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
595495007864	substrate binding site [chemical binding]; other site
595495007865	active site
595495007866	catalytic residues [active]
595495007867	heterodimer interface [polypeptide binding]; other site
595495007868	General stress protein [General function prediction only]; Region: GsiB; COG3729
595495007869	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
595495007870	dimerization interface [polypeptide binding]; other site
595495007871	metal binding site [ion binding]; metal-binding site
595495007872	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685
595495007873	outer membrane protein W; Provisional; Region: PRK10959
595495007874	hypothetical protein; Provisional; Region: PRK02868
595495007875	intracellular septation protein A; Reviewed; Region: PRK00259
595495007876	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
595495007877	transport protein TonB; Provisional; Region: PRK10819
595495007878	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
595495007879	YciI-like protein; Reviewed; Region: PRK11370
595495007880	voltage-gated potassium channel; Provisional; Region: PRK10537
595495007881	Ion channel; Region: Ion_trans_2; pfam07885
595495007882	TrkA-N domain; Region: TrkA_N; pfam02254
595495007883	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
595495007884	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
595495007885	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
595495007886	putative active site [active]
595495007887	catalytic site [active]
595495007888	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
595495007889	putative active site [active]
595495007890	catalytic site [active]
595495007891	dsDNA-mimic protein; Reviewed; Region: PRK05094
595495007892	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
595495007893	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
595495007894	Walker A/P-loop; other site
595495007895	ATP binding site [chemical binding]; other site
595495007896	Q-loop/lid; other site
595495007897	ABC transporter signature motif; other site
595495007898	Walker B; other site
595495007899	D-loop; other site
595495007900	H-loop/switch region; other site
595495007901	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
595495007902	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
595495007903	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
595495007904	Walker A/P-loop; other site
595495007905	ATP binding site [chemical binding]; other site
595495007906	Q-loop/lid; other site
595495007907	ABC transporter signature motif; other site
595495007908	Walker B; other site
595495007909	D-loop; other site
595495007910	H-loop/switch region; other site
595495007911	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
595495007912	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
595495007913	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
595495007914	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495007915	dimer interface [polypeptide binding]; other site
595495007916	conserved gate region; other site
595495007917	putative PBP binding loops; other site
595495007918	ABC-ATPase subunit interface; other site
595495007919	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
595495007920	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495007921	dimer interface [polypeptide binding]; other site
595495007922	conserved gate region; other site
595495007923	putative PBP binding loops; other site
595495007924	ABC-ATPase subunit interface; other site
595495007925	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
595495007926	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
595495007927	peptide binding site [polypeptide binding]; other site
595495007928	hypothetical protein; Provisional; Region: PRK11111
595495007929	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
595495007930	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
595495007931	putative catalytic cysteine [active]
595495007932	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
595495007933	putative active site [active]
595495007934	metal binding site [ion binding]; metal-binding site
595495007935	thymidine kinase; Provisional; Region: PRK04296
595495007936	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
595495007937	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
595495007938	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
595495007939	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
595495007940	active site
595495007941	tetramer interface; other site
595495007942	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495007943	active site
595495007944	response regulator of RpoS; Provisional; Region: PRK10693
595495007945	phosphorylation site [posttranslational modification]
595495007946	intermolecular recognition site; other site
595495007947	dimerization interface [polypeptide binding]; other site
595495007948	hypothetical protein; Provisional; Region: PRK10279
595495007949	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
595495007950	active site
595495007951	nucleophile elbow; other site
595495007952	SEC-C motif; Region: SEC-C; pfam02810
595495007953	hypothetical protein; Provisional; Region: PRK04233
595495007954	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
595495007955	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
595495007956	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
595495007957	putative active site [active]
595495007958	putative substrate binding site [chemical binding]; other site
595495007959	putative cosubstrate binding site; other site
595495007960	catalytic site [active]
595495007961	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
595495007962	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
595495007963	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
595495007964	4Fe-4S binding domain; Region: Fer4; cl02805
595495007965	respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580
595495007966	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
595495007967	[4Fe-4S] binding site [ion binding]; other site
595495007968	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
595495007969	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
595495007970	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
595495007971	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
595495007972	molybdopterin cofactor binding site; other site
595495007973	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
595495007974	nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600
595495007975	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
595495007976	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
595495007977	dimerization interface [polypeptide binding]; other site
595495007978	Histidine kinase; Region: HisKA_3; pfam07730
595495007979	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495007980	ATP binding site [chemical binding]; other site
595495007981	Mg2+ binding site [ion binding]; other site
595495007982	G-X-G motif; other site
595495007983	transcriptional regulator NarL; Provisional; Region: PRK10651
595495007984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495007985	active site
595495007986	phosphorylation site [posttranslational modification]
595495007987	intermolecular recognition site; other site
595495007988	dimerization interface [polypeptide binding]; other site
595495007989	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
595495007990	DNA binding residues [nucleotide binding]
595495007991	dimerization interface [polypeptide binding]; other site
595495007992	putative invasin; Provisional; Region: PRK10177
595495007993	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
595495007994	Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553
595495007995	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
595495007996	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
595495007997	putative active site pocket [active]
595495007998	dimerization interface [polypeptide binding]; other site
595495007999	putative catalytic residue [active]
595495008000	cation transport regulator; Reviewed; Region: chaB; PRK09582
595495008001	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
595495008002	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
595495008003	Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940
595495008004	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
595495008005	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
595495008006	hypothetical protein; Provisional; Region: PRK10941
595495008007	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
595495008008	hypothetical protein; Provisional; Region: PRK10278
595495008009	HemK family putative methylases; Region: hemK_fam; TIGR00536
595495008010	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495008011	peptide chain release factor 1; Validated; Region: prfA; PRK00591
595495008012	This domain is found in peptide chain release factors; Region: PCRF; smart00937
595495008013	RF-1 domain; Region: RF-1; pfam00472
595495008014	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
595495008015	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
595495008016	tRNA; other site
595495008017	putative tRNA binding site [nucleotide binding]; other site
595495008018	putative NADP binding site [chemical binding]; other site
595495008019	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
595495008020	outer membrane lipoprotein LolB; Region: lolB; TIGR00548
595495008021	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
595495008022	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
595495008023	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
595495008024	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
595495008025	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
595495008026	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
595495008027	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
595495008028	active site
595495008029	putative transporter; Provisional; Region: PRK11660
595495008030	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
595495008031	Sulfate transporter family; Region: Sulfate_transp; pfam00916
595495008032	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
595495008033	hypothetical protein; Provisional; Region: PRK10692
595495008034	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
595495008035	putative active site [active]
595495008036	catalytic residue [active]
595495008037	GTP-binding protein YchF; Reviewed; Region: PRK09601
595495008038	YchF GTPase; Region: YchF; cd01900
595495008039	G1 box; other site
595495008040	GTP/Mg2+ binding site [chemical binding]; other site
595495008041	Switch I region; other site
595495008042	G2 box; other site
595495008043	Switch II region; other site
595495008044	G3 box; other site
595495008045	G4 box; other site
595495008046	G5 box; other site
595495008047	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
595495008048	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
595495008049	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
595495008050	Autotransporter beta-domain; Region: Autotransporter; pfam03797
595495008051	DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388
595495008052	PAS domain; Region: PAS; smart00091
595495008053	putative active site [active]
595495008054	heme pocket [chemical binding]; other site
595495008055	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495008056	Walker A motif; other site
595495008057	ATP binding site [chemical binding]; other site
595495008058	Walker B motif; other site
595495008059	arginine finger; other site
595495008060	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
595495008061	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468
595495008062	Dak1 domain; Region: Dak1; pfam02733
595495008063	dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005
595495008064	dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377
595495008065	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412
595495008066	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
595495008067	dimerization domain swap beta strand [polypeptide binding]; other site
595495008068	regulatory protein interface [polypeptide binding]; other site
595495008069	active site
595495008070	regulatory phosphorylation site [posttranslational modification]; other site
595495008071	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
595495008072	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
595495008073	trehalase; Provisional; Region: treA; PRK13271
595495008074	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
595495008075	hypothetical protein; Provisional; Region: PRK10457
595495008076	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
595495008077	Flagellar regulator YcgR; Region: YcgR; pfam07317
595495008078	PilZ domain; Region: PilZ; pfam07238
595495008079	lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470
595495008080	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
595495008081	N-acetyl-D-glucosamine binding site [chemical binding]; other site
595495008082	catalytic residue [active]
595495008083	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
595495008084	dimer interface [polypeptide binding]; other site
595495008085	catalytic triad [active]
595495008086	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
595495008087	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
595495008088	TrkA-C domain; Region: TrkA_C; pfam02080
595495008089	Transporter associated domain; Region: CorC_HlyC; smart01091
595495008090	alanine racemase; Reviewed; Region: dadX; PRK03646
595495008091	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
595495008092	active site
595495008093	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
595495008094	substrate binding site [chemical binding]; other site
595495008095	catalytic residues [active]
595495008096	dimer interface [polypeptide binding]; other site
595495008097	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
595495008098	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
595495008099	SpoVR family protein; Provisional; Region: PRK11767
595495008100	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
595495008101	fatty acid metabolism regulator; Provisional; Region: PRK04984
595495008102	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495008103	DNA-binding site [nucleotide binding]; DNA binding site
595495008104	FadR C-terminal domain; Region: FadR_C; pfam07840
595495008105	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
595495008106	transmembrane helices; other site
595495008107	disulfide bond formation protein B; Provisional; Region: PRK01749
595495008108	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
595495008109	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
595495008110	active site
595495008111	DNA binding site [nucleotide binding]
595495008112	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
595495008113	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
595495008114	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
595495008115	Catalytic site [active]
595495008116	hypothetical protein; Provisional; Region: PRK05170
595495008117	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
595495008118	hypothetical protein; Provisional; Region: PRK10691
595495008119	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100
595495008120	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
595495008121	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
595495008122	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
595495008123	septum formation inhibitor; Reviewed; Region: minC; PRK03511
595495008124	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
595495008125	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
595495008126	cell division inhibitor MinD; Provisional; Region: PRK10818
595495008127	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
595495008128	Switch I; other site
595495008129	Switch II; other site
595495008130	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
595495008131	Autotransporter beta-domain; Region: Autotransporter; smart00869
595495008132	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
595495008133	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
595495008134	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
595495008135	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
595495008136	Sensors of blue-light using FAD; Region: BLUF; smart01034
595495008137	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
595495008138	transcriptional regulator MirA; Provisional; Region: PRK15043
595495008139	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
595495008140	DNA binding residues [nucleotide binding]
595495008141	Protein of unknown function (DUF1398); Region: DUF1398; pfam07166
595495008142	anti-adapter protein IraM; Provisional; Region: PRK09919
595495008143	isocitrate dehydrogenase; Validated; Region: PRK07362
595495008144	isocitrate dehydrogenase; Reviewed; Region: PRK07006
595495008145	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
595495008146	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
595495008147	probable active site [active]
595495008148	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
595495008149	nudix motif; other site
595495008150	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
595495008151	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
595495008152	putative lysogenization regulator; Reviewed; Region: PRK00218
595495008153	adenylosuccinate lyase; Provisional; Region: PRK09285
595495008154	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
595495008155	tetramer interface [polypeptide binding]; other site
595495008156	active site
595495008157	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
595495008158	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495008159	active site
595495008160	phosphorylation site [posttranslational modification]
595495008161	intermolecular recognition site; other site
595495008162	dimerization interface [polypeptide binding]; other site
595495008163	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
595495008164	DNA binding site [nucleotide binding]
595495008165	sensor protein PhoQ; Provisional; Region: PRK10815
595495008166	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
595495008167	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
595495008168	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
595495008169	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495008170	ATP binding site [chemical binding]; other site
595495008171	Mg2+ binding site [ion binding]; other site
595495008172	G-X-G motif; other site
595495008173	Uncharacterized conserved protein [Function unknown]; Region: COG2850
595495008174	Cupin-like domain; Region: Cupin_8; pfam13621
595495008175	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
595495008176	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
595495008177	metal binding site [ion binding]; metal-binding site
595495008178	dimer interface [polypeptide binding]; other site
595495008179	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
595495008180	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495008181	Walker A/P-loop; other site
595495008182	ATP binding site [chemical binding]; other site
595495008183	Q-loop/lid; other site
595495008184	ABC transporter signature motif; other site
595495008185	Walker B; other site
595495008186	D-loop; other site
595495008187	H-loop/switch region; other site
595495008188	TOBE domain; Region: TOBE_2; pfam08402
595495008189	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
595495008190	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495008191	dimer interface [polypeptide binding]; other site
595495008192	conserved gate region; other site
595495008193	putative PBP binding loops; other site
595495008194	ABC-ATPase subunit interface; other site
595495008195	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
595495008196	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495008197	dimer interface [polypeptide binding]; other site
595495008198	conserved gate region; other site
595495008199	putative PBP binding loops; other site
595495008200	ABC-ATPase subunit interface; other site
595495008201	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
595495008202	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
595495008203	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
595495008204	Repair protein; Region: Repair_PSII; cl01535
595495008205	NAD-dependent deacetylase; Provisional; Region: PRK00481
595495008206	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
595495008207	NAD+ binding site [chemical binding]; other site
595495008208	substrate binding site [chemical binding]; other site
595495008209	Zn binding site [ion binding]; other site
595495008210	fructokinase; Reviewed; Region: PRK09557
595495008211	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
595495008212	nucleotide binding site [chemical binding]; other site
595495008213	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
595495008214	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
595495008215	FtsX-like permease family; Region: FtsX; pfam02687
595495008216	lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629
595495008217	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
595495008218	Walker A/P-loop; other site
595495008219	ATP binding site [chemical binding]; other site
595495008220	Q-loop/lid; other site
595495008221	ABC transporter signature motif; other site
595495008222	Walker B; other site
595495008223	D-loop; other site
595495008224	H-loop/switch region; other site
595495008225	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
595495008226	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
595495008227	FtsX-like permease family; Region: FtsX; pfam02687
595495008228	Predicted membrane protein [Function unknown]; Region: COG4763
595495008229	Acyltransferase family; Region: Acyl_transf_3; pfam01757
595495008230	transcription-repair coupling factor; Provisional; Region: PRK10689
595495008231	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
595495008232	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
595495008233	ATP binding site [chemical binding]; other site
595495008234	putative Mg++ binding site [ion binding]; other site
595495008235	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
595495008236	nucleotide binding region [chemical binding]; other site
595495008237	ATP-binding site [chemical binding]; other site
595495008238	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
595495008239	L,D-transpeptidase; Provisional; Region: PRK10260
595495008240	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
595495008241	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
595495008242	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
595495008243	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
595495008244	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
595495008245	hypothetical protein; Provisional; Region: PRK11280
595495008246	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
595495008247	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
595495008248	hypothetical protein; Provisional; Region: PRK04940
595495008249	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
595495008250	beta-hexosaminidase; Provisional; Region: PRK05337
595495008251	thiamine kinase; Region: ycfN_thiK; TIGR02721
595495008252	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
595495008253	active site
595495008254	substrate binding site [chemical binding]; other site
595495008255	ATP binding site [chemical binding]; other site
595495008256	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
595495008257	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
595495008258	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
595495008259	putative dimer interface [polypeptide binding]; other site
595495008260	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
595495008261	nucleotide binding site/active site [active]
595495008262	HIT family signature motif; other site
595495008263	catalytic residue [active]
595495008264	ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003
595495008265	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
595495008266	N-terminal plug; other site
595495008267	ligand-binding site [chemical binding]; other site
595495008268	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
595495008269	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
595495008270	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
595495008271	active site turn [active]
595495008272	phosphorylation site [posttranslational modification]
595495008273	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
595495008274	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
595495008275	active site
595495008276	DNA polymerase III subunit delta'; Validated; Region: PRK07993
595495008277	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
595495008278	thymidylate kinase; Validated; Region: tmk; PRK00698
595495008279	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
595495008280	TMP-binding site; other site
595495008281	ATP-binding site [chemical binding]; other site
595495008282	conserved hypothetical protein, YceG family; Region: TIGR00247
595495008283	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
595495008284	dimerization interface [polypeptide binding]; other site
595495008285	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
595495008286	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
595495008287	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495008288	catalytic residue [active]
595495008289	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
595495008290	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
595495008291	dimer interface [polypeptide binding]; other site
595495008292	active site
595495008293	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
595495008294	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
595495008295	NAD(P) binding site [chemical binding]; other site
595495008296	homotetramer interface [polypeptide binding]; other site
595495008297	homodimer interface [polypeptide binding]; other site
595495008298	active site
595495008299	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
595495008300	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
595495008301	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
595495008302	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
595495008303	dimer interface [polypeptide binding]; other site
595495008304	active site
595495008305	CoA binding pocket [chemical binding]; other site
595495008306	putative phosphate acyltransferase; Provisional; Region: PRK05331
595495008307	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
595495008308	hypothetical protein; Provisional; Region: PRK11193
595495008309	Maf-like protein; Region: Maf; pfam02545
595495008310	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
595495008311	active site
595495008312	dimer interface [polypeptide binding]; other site
595495008313	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
595495008314	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
595495008315	RNA binding surface [nucleotide binding]; other site
595495008316	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
595495008317	active site
595495008318	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
595495008319	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
595495008320	homodimer interface [polypeptide binding]; other site
595495008321	oligonucleotide binding site [chemical binding]; other site
595495008322	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
595495008323	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027
595495008324	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
595495008325	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147
595495008326	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
595495008327	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
595495008328	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
595495008329	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
595495008330	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
595495008331	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
595495008332	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
595495008333	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
595495008334	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
595495008335	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
595495008336	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
595495008337	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
595495008338	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787
595495008339	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
595495008340	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
595495008341	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
595495008342	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
595495008343	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
595495008344	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
595495008345	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
595495008346	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
595495008347	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
595495008348	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
595495008349	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
595495008350	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
595495008351	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
595495008352	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
595495008353	Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261
595495008354	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
595495008355	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
595495008356	anti-sigma28 factor FlgM; Provisional; Region: PRK10810
595495008357	flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459
595495008358	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
595495008359	MviN-like protein; Region: MVIN; pfam03023
595495008360	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
595495008361	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
595495008362	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
595495008363	hypothetical protein; Provisional; Region: PRK11239
595495008364	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132
595495008365	ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809
595495008366	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
595495008367	multidrug resistance protein MdtH; Provisional; Region: PRK11646
595495008368	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495008369	putative substrate translocation pore; other site
595495008370	glutaredoxin 2; Provisional; Region: PRK10387
595495008371	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
595495008372	C-terminal domain interface [polypeptide binding]; other site
595495008373	GSH binding site (G-site) [chemical binding]; other site
595495008374	catalytic residues [active]
595495008375	putative dimer interface [polypeptide binding]; other site
595495008376	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
595495008377	N-terminal domain interface [polypeptide binding]; other site
595495008378	lipoprotein; Provisional; Region: PRK10598
595495008379	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
595495008380	active site
595495008381	substrate binding pocket [chemical binding]; other site
595495008382	dimer interface [polypeptide binding]; other site
595495008383	DNA damage-inducible protein I; Provisional; Region: PRK10597
595495008384	biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301
595495008385	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
595495008386	hydroxyglutarate oxidase; Provisional; Region: PRK11728
595495008387	Protein of unknown function (DUF2770); Region: DUF2770; pfam10968
595495008388	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
595495008389	hypothetical protein; Provisional; Region: PRK03757
595495008390	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
595495008391	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
595495008392	active site residue [active]
595495008393	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
595495008394	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
595495008395	putative acyl-acceptor binding pocket; other site
595495008396	drug efflux system protein MdtG; Provisional; Region: PRK09874
595495008397	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495008398	putative substrate translocation pore; other site
595495008399	secY/secA suppressor protein; Provisional; Region: PRK11467
595495008400	lipoprotein; Provisional; Region: PRK10175
595495008401	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
595495008402	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
595495008403	Ligand binding site; other site
595495008404	DXD motif; other site
595495008405	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
595495008406	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349
595495008407	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
595495008408	Acyltransferase family; Region: Acyl_transf_3; pfam01757
595495008409	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
595495008410	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
595495008411	putative active site [active]
595495008412	catalytic site [active]
595495008413	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
595495008414	putative active site [active]
595495008415	catalytic site [active]
595495008416	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
595495008417	putative ADP-ribose binding site [chemical binding]; other site
595495008418	putative active site [active]
595495008419	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
595495008420	curli assembly protein CsgC; Provisional; Region: csgC; PRK10102
595495008421	major curlin subunit; Provisional; Region: csgA; PRK10051
595495008422	Curlin associated repeat; Region: Curlin_rpt; pfam07012
595495008423	Curlin associated repeat; Region: Curlin_rpt; pfam07012
595495008424	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
595495008425	Curlin associated repeat; Region: Curlin_rpt; pfam07012
595495008426	Curlin associated repeat; Region: Curlin_rpt; pfam07012
595495008427	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
595495008428	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
595495008429	DNA binding residues [nucleotide binding]
595495008430	dimerization interface [polypeptide binding]; other site
595495008431	curli assembly protein CsgE; Provisional; Region: PRK10386
595495008432	curli assembly protein CsgF; Provisional; Region: PRK10050
595495008433	curli production assembly/transport protein CsgG; Provisional; Region: PRK15184
595495008434	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
595495008435	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
595495008436	putative hydrolase; Validated; Region: PRK09248
595495008437	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
595495008438	active site
595495008439	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
595495008440	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
595495008441	putative ligand binding site [chemical binding]; other site
595495008442	NAD binding site [chemical binding]; other site
595495008443	dimerization interface [polypeptide binding]; other site
595495008444	catalytic site [active]
595495008445	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
595495008446	Transposase; Region: HTH_Tnp_1; cl17663
595495008447	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
595495008448	putative transposase OrfB; Reviewed; Region: PHA02517
595495008449	HTH-like domain; Region: HTH_21; pfam13276
595495008450	Integrase core domain; Region: rve; pfam00665
595495008451	Integrase core domain; Region: rve_2; pfam13333
595495008452	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
595495008453	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
595495008454	metal binding site [ion binding]; metal-binding site
595495008455	active site
595495008456	I-site; other site
595495008457	outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049
595495008458	outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582
595495008459	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
595495008460	putative active site [active]
595495008461	putative metal binding site [ion binding]; other site
595495008462	N-glycosyltransferase; Provisional; Region: PRK11204
595495008463	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
595495008464	DXD motif; other site
595495008465	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
595495008466	putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585
595495008467	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
595495008468	hypothetical protein; Provisional; Region: PRK10536
595495008469	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
595495008470	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
595495008471	inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378
595495008472	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
595495008473	Imelysin; Region: Peptidase_M75; pfam09375
595495008474	FTR1 family protein; Region: TIGR00145
595495008475	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
595495008476	Na binding site [ion binding]; other site
595495008477	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
595495008478	Predicted transcriptional regulator [Transcription]; Region: COG3905
595495008479	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
595495008480	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
595495008481	Glutamate binding site [chemical binding]; other site
595495008482	NAD binding site [chemical binding]; other site
595495008483	catalytic residues [active]
595495008484	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
595495008485	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
595495008486	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
595495008487	pyrimidine utilization protein A; Region: RutA; TIGR03612
595495008488	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
595495008489	active site
595495008490	dimer interface [polypeptide binding]; other site
595495008491	non-prolyl cis peptide bond; other site
595495008492	insertion regions; other site
595495008493	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
595495008494	Isochorismatase family; Region: Isochorismatase; pfam00857
595495008495	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
595495008496	catalytic triad [active]
595495008497	conserved cis-peptide bond; other site
595495008498	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
595495008499	homotrimer interaction site [polypeptide binding]; other site
595495008500	putative active site [active]
595495008501	pyrimidine utilization protein D; Region: RutD; TIGR03611
595495008502	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
595495008503	putative FMN binding site [chemical binding]; other site
595495008504	pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615
595495008505	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
595495008506	General stress protein [General function prediction only]; Region: GsiB; COG3729
595495008507	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
595495008508	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
595495008509	hypothetical protein; Provisional; Region: PRK10174
595495008510	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
595495008511	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
595495008512	catalytic core [active]
595495008513	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
595495008514	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
595495008515	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
595495008516	HSP70 interaction site [polypeptide binding]; other site
595495008517	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
595495008518	substrate binding site [polypeptide binding]; other site
595495008519	dimer interface [polypeptide binding]; other site
595495008520	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
595495008521	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
595495008522	chaperone protein TorD; Validated; Region: torD; PRK04976
595495008523	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
595495008524	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
595495008525	molybdopterin cofactor binding site [chemical binding]; other site
595495008526	substrate binding site [chemical binding]; other site
595495008527	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
595495008528	molybdopterin cofactor binding site; other site
595495008529	trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032
595495008530	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
595495008531	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
595495008532	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495008533	active site
595495008534	phosphorylation site [posttranslational modification]
595495008535	intermolecular recognition site; other site
595495008536	dimerization interface [polypeptide binding]; other site
595495008537	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
595495008538	DNA binding site [nucleotide binding]
595495008539	TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936
595495008540	TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306
595495008541	putative ligand binding site [chemical binding]; other site
595495008542	hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466
595495008543	HAMP domain; Region: HAMP; pfam00672
595495008544	dimerization interface [polypeptide binding]; other site
595495008545	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
595495008546	dimer interface [polypeptide binding]; other site
595495008547	phosphorylation site [posttranslational modification]
595495008548	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495008549	ATP binding site [chemical binding]; other site
595495008550	Mg2+ binding site [ion binding]; other site
595495008551	G-X-G motif; other site
595495008552	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495008553	active site
595495008554	phosphorylation site [posttranslational modification]
595495008555	intermolecular recognition site; other site
595495008556	dimerization interface [polypeptide binding]; other site
595495008557	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
595495008558	putative binding surface; other site
595495008559	active site
595495008560	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
595495008561	4Fe-4S binding domain; Region: Fer4_5; pfam12801
595495008562	4Fe-4S binding domain; Region: Fer4_5; pfam12801
595495008563	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
595495008564	GnsA/GnsB family; Region: GnsAB; pfam08178
595495008565	cold shock gene; Provisional; Region: PRK09891
595495008566	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
595495008567	DNA-binding site [nucleotide binding]; DNA binding site
595495008568	RNA-binding motif; other site
595495008569	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
595495008570	DNA-binding site [nucleotide binding]; DNA binding site
595495008571	RNA-binding motif; other site
595495008572	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
595495008573	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
595495008574	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
595495008575	polysaccharide export protein Wza; Provisional; Region: PRK15078
595495008576	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
595495008577	SLBB domain; Region: SLBB; pfam10531
595495008578	SLBB domain; Region: SLBB; pfam10531
595495008579	Low molecular weight phosphatase family; Region: LMWPc; cd00115
595495008580	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
595495008581	active site
595495008582	cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841
595495008583	Chain length determinant protein; Region: Wzz; pfam02706
595495008584	Chain length determinant protein; Region: Wzz; cl15801
595495008585	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
595495008586	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
595495008587	Nucleotide binding site [chemical binding]; other site
595495008588	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
595495008589	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
595495008590	catalytic core [active]
595495008591	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
595495008592	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
595495008593	cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028
595495008594	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
595495008595	cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035
595495008596	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
595495008597	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
595495008598	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
595495008599	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
595495008600	putative substrate-binding site; other site
595495008601	nickel binding site [ion binding]; other site
595495008602	hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171
595495008603	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
595495008604	hydrogenase 1 large subunit; Provisional; Region: PRK10170
595495008605	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
595495008606	hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391
595495008607	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
595495008608	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
595495008609	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
595495008610	YccA-like proteins; Region: YccA_like; cd10433
595495008611	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
595495008612	sulfur transfer protein TusE; Provisional; Region: PRK11508
595495008613	Acylphosphatase; Region: Acylphosphatase; cl00551
595495008614	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
595495008615	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
595495008616	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
595495008617	putative RNA binding site [nucleotide binding]; other site
595495008618	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495008619	S-adenosylmethionine binding site [chemical binding]; other site
595495008620	heat shock protein HspQ; Provisional; Region: PRK14129
595495008621	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
595495008622	hypothetical protein; Provisional; Region: PRK03641
595495008623	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110
595495008624	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
595495008625	active site
595495008626	dimer interfaces [polypeptide binding]; other site
595495008627	catalytic residues [active]
595495008628	DNA helicase IV; Provisional; Region: helD; PRK11054
595495008629	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
595495008630	Part of AAA domain; Region: AAA_19; pfam13245
595495008631	Family description; Region: UvrD_C_2; pfam13538
595495008632	Predicted membrane protein [Function unknown]; Region: COG3304
595495008633	Domain of unknown function (DUF307); Region: DUF307; pfam03733
595495008634	Domain of unknown function (DUF307); Region: DUF307; pfam03733
595495008635	TIGR01666 family membrane protein; Region: YCCS
595495008636	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
595495008637	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
595495008638	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
595495008639	TfoX C-terminal domain; Region: TfoX_C; pfam04994
595495008640	cell division inhibitor SulA; Region: sula; TIGR00623
595495008641	outer membrane protein A; Reviewed; Region: PRK10808
595495008642	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
595495008643	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
595495008644	ligand binding site [chemical binding]; other site
595495008645	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
595495008646	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
595495008647	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
595495008648	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
595495008649	active site 1 [active]
595495008650	dimer interface [polypeptide binding]; other site
595495008651	active site 2 [active]
595495008652	ribosome modulation factor; Provisional; Region: PRK14563
595495008653	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
595495008654	Protein of unknown function (DUF330); Region: DUF330; pfam03886
595495008655	paraquat-inducible protein B; Provisional; Region: PRK10807
595495008656	mce related protein; Region: MCE; pfam02470
595495008657	mce related protein; Region: MCE; pfam02470
595495008658	mce related protein; Region: MCE; pfam02470
595495008659	DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651
595495008660	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
595495008661	Paraquat-inducible protein A; Region: PqiA; pfam04403
595495008662	Paraquat-inducible protein A; Region: PqiA; pfam04403
595495008663	ABC transporter ATPase component; Reviewed; Region: PRK11147
595495008664	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495008665	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495008666	Walker A/P-loop; other site
595495008667	Walker A/P-loop; other site
595495008668	ATP binding site [chemical binding]; other site
595495008669	ATP binding site [chemical binding]; other site
595495008670	Q-loop/lid; other site
595495008671	Q-loop/lid; other site
595495008672	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
595495008673	ABC transporter signature motif; other site
595495008674	Walker B; other site
595495008675	D-loop; other site
595495008676	ABC transporter; Region: ABC_tran_2; pfam12848
595495008677	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
595495008678	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
595495008679	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
595495008680	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
595495008681	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495008682	S-adenosylmethionine binding site [chemical binding]; other site
595495008683	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
595495008684	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
595495008685	MOSC domain; Region: MOSC; pfam03473
595495008686	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
595495008687	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
595495008688	catalytic loop [active]
595495008689	iron binding site [ion binding]; other site
595495008690	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
595495008691	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
595495008692	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
595495008693	quinone interaction residues [chemical binding]; other site
595495008694	active site
595495008695	catalytic residues [active]
595495008696	FMN binding site [chemical binding]; other site
595495008697	substrate binding site [chemical binding]; other site
595495008698	putativi pili assembly chaperone; Provisional; Region: PRK11385
595495008699	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
595495008700	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
595495008701	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
595495008702	Fimbrial protein; Region: Fimbrial; cl01416
595495008703	Fimbrial protein; Region: Fimbrial; cl01416
595495008704	outer membrane usher protein; Provisional; Region: PRK15193
595495008705	PapC N-terminal domain; Region: PapC_N; pfam13954
595495008706	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
595495008707	PapC C-terminal domain; Region: PapC_C; pfam13953
595495008708	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
595495008709	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
595495008710	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
595495008711	Fimbrial protein; Region: Fimbrial; cl01416
595495008712	NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569
595495008713	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
595495008714	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
595495008715	substrate binding pocket [chemical binding]; other site
595495008716	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
595495008717	membrane-bound complex binding site; other site
595495008718	hinge residues; other site
595495008719	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
595495008720	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
595495008721	active site
595495008722	dimer interface [polypeptide binding]; other site
595495008723	non-prolyl cis peptide bond; other site
595495008724	insertion regions; other site
595495008725	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
595495008726	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495008727	dimer interface [polypeptide binding]; other site
595495008728	conserved gate region; other site
595495008729	putative PBP binding loops; other site
595495008730	ABC-ATPase subunit interface; other site
595495008731	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
595495008732	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
595495008733	Walker A/P-loop; other site
595495008734	ATP binding site [chemical binding]; other site
595495008735	Q-loop/lid; other site
595495008736	ABC transporter signature motif; other site
595495008737	Walker B; other site
595495008738	D-loop; other site
595495008739	H-loop/switch region; other site
595495008740	aminopeptidase N; Provisional; Region: pepN; PRK14015
595495008741	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
595495008742	active site
595495008743	Zn binding site [ion binding]; other site
595495008744	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
595495008745	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
595495008746	active site
595495008747	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
595495008748	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
595495008749	putative dimer interface [polypeptide binding]; other site
595495008750	putative anticodon binding site; other site
595495008751	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
595495008752	homodimer interface [polypeptide binding]; other site
595495008753	motif 1; other site
595495008754	motif 2; other site
595495008755	active site
595495008756	motif 3; other site
595495008757	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
595495008758	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
595495008759	trimer interface [polypeptide binding]; other site
595495008760	eyelet of channel; other site
595495008761	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
595495008762	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
595495008763	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495008764	homodimer interface [polypeptide binding]; other site
595495008765	catalytic residue [active]
595495008766	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
595495008767	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
595495008768	Peptidase M15; Region: Peptidase_M15_3; cl01194
595495008769	murein L,D-transpeptidase; Provisional; Region: PRK10594
595495008770	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
595495008771	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
595495008772	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
595495008773	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
595495008774	MukB N-terminal; Region: MukB; pfam04310
595495008775	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
595495008776	condesin subunit E; Provisional; Region: PRK05256
595495008777	condesin subunit F; Provisional; Region: PRK05260
595495008778	Methyltransferase domain; Region: Methyltransf_31; pfam13847
595495008779	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495008780	S-adenosylmethionine binding site [chemical binding]; other site
595495008781	Uncharacterized conserved protein [Function unknown]; Region: COG1434
595495008782	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
595495008783	putative active site [active]
595495008784	hypothetical protein; Provisional; Region: PRK10593
595495008785	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
595495008786	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
595495008787	Ligand binding site; other site
595495008788	oligomer interface; other site
595495008789	hypothetical protein; Provisional; Region: PRK11827
595495008790	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
595495008791	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
595495008792	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
595495008793	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
595495008794	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
595495008795	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
595495008796	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
595495008797	Walker A/P-loop; other site
595495008798	ATP binding site [chemical binding]; other site
595495008799	Q-loop/lid; other site
595495008800	ABC transporter signature motif; other site
595495008801	Walker B; other site
595495008802	D-loop; other site
595495008803	H-loop/switch region; other site
595495008804	ComEC family competence protein; Provisional; Region: PRK11539
595495008805	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
595495008806	ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360
595495008807	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
595495008808	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
595495008809	IHF dimer interface [polypeptide binding]; other site
595495008810	IHF - DNA interface [nucleotide binding]; other site
595495008811	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
595495008812	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
595495008813	RNA binding site [nucleotide binding]; other site
595495008814	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
595495008815	RNA binding site [nucleotide binding]; other site
595495008816	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
595495008817	RNA binding site [nucleotide binding]; other site
595495008818	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
595495008819	RNA binding site [nucleotide binding]; other site
595495008820	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
595495008821	RNA binding site [nucleotide binding]; other site
595495008822	cytidylate kinase; Provisional; Region: cmk; PRK00023
595495008823	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
595495008824	CMP-binding site; other site
595495008825	The sites determining sugar specificity; other site
595495008826	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
595495008827	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
595495008828	Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554
595495008829	hinge; other site
595495008830	active site
595495008831	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
595495008832	homodimer interface [polypeptide binding]; other site
595495008833	substrate-cofactor binding pocket; other site
595495008834	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495008835	catalytic residue [active]
595495008836	Predicted membrane protein [Function unknown]; Region: COG2323
595495008837	uncharacterized domain; Region: TIGR00702
595495008838	YcaO-like family; Region: YcaO; pfam02624
595495008839	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
595495008840	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
595495008841	dimer interface [polypeptide binding]; other site
595495008842	PYR/PP interface [polypeptide binding]; other site
595495008843	TPP binding site [chemical binding]; other site
595495008844	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
595495008845	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
595495008846	TPP-binding site [chemical binding]; other site
595495008847	dimer interface [polypeptide binding]; other site
595495008848	putative alcohol dehydrogenase; Provisional; Region: PRK09860
595495008849	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
595495008850	dimer interface [polypeptide binding]; other site
595495008851	active site
595495008852	metal binding site [ion binding]; metal-binding site
595495008853	chloramphenicol acetyltransferase; Provisional; Region: PRK13757
595495008854	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
595495008855	formate transporter; Provisional; Region: PRK10805
595495008856	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
595495008857	Pyruvate formate lyase 1; Region: PFL1; cd01678
595495008858	coenzyme A binding site [chemical binding]; other site
595495008859	active site
595495008860	catalytic residues [active]
595495008861	glycine loop; other site
595495008862	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
595495008863	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
595495008864	FeS/SAM binding site; other site
595495008865	hypothetical protein; Provisional; Region: PRK09739
595495008866	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
595495008867	Transcriptional regulator [Transcription]; Region: LysR; COG0583
595495008868	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495008869	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
595495008870	putative effector binding pocket; other site
595495008871	putative dimerization interface [polypeptide binding]; other site
595495008872	Amino acid permease; Region: AA_permease_2; pfam13520
595495008873	putative MFS family transporter protein; Provisional; Region: PRK03633
595495008874	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495008875	putative substrate translocation pore; other site
595495008876	Isochorismatase family; Region: Isochorismatase; pfam00857
595495008877	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
595495008878	catalytic triad [active]
595495008879	dimer interface [polypeptide binding]; other site
595495008880	conserved cis-peptide bond; other site
595495008881	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
595495008882	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
595495008883	4Fe-4S binding domain; Region: Fer4; pfam00037
595495008884	anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990
595495008885	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
595495008886	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
595495008887	putative [Fe4-S4] binding site [ion binding]; other site
595495008888	putative molybdopterin cofactor binding site [chemical binding]; other site
595495008889	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
595495008890	putative molybdopterin cofactor binding site; other site
595495008891	seryl-tRNA synthetase; Provisional; Region: PRK05431
595495008892	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
595495008893	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
595495008894	dimer interface [polypeptide binding]; other site
595495008895	active site
595495008896	motif 1; other site
595495008897	motif 2; other site
595495008898	motif 3; other site
595495008899	recombination factor protein RarA; Reviewed; Region: PRK13342
595495008900	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495008901	Walker A motif; other site
595495008902	ATP binding site [chemical binding]; other site
595495008903	Walker B motif; other site
595495008904	arginine finger; other site
595495008905	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
595495008906	periplasmic chaperone LolA; Region: lolA; TIGR00547
595495008907	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
595495008908	DNA translocase FtsK; Provisional; Region: PRK10263
595495008909	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
595495008910	DNA translocase FtsK; Provisional; Region: PRK10263
595495008911	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
595495008912	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
595495008913	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
595495008914	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
595495008915	putative DNA binding site [nucleotide binding]; other site
595495008916	putative Zn2+ binding site [ion binding]; other site
595495008917	AsnC family; Region: AsnC_trans_reg; pfam01037
595495008918	thioredoxin reductase; Provisional; Region: PRK10262
595495008919	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
595495008920	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
595495008921	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
595495008922	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
595495008923	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495008924	Walker A/P-loop; other site
595495008925	ATP binding site [chemical binding]; other site
595495008926	Q-loop/lid; other site
595495008927	ABC transporter signature motif; other site
595495008928	Walker B; other site
595495008929	D-loop; other site
595495008930	H-loop/switch region; other site
595495008931	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
595495008932	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
595495008933	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
595495008934	Walker A/P-loop; other site
595495008935	ATP binding site [chemical binding]; other site
595495008936	Q-loop/lid; other site
595495008937	ABC transporter signature motif; other site
595495008938	Walker B; other site
595495008939	D-loop; other site
595495008940	H-loop/switch region; other site
595495008941	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
595495008942	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
595495008943	rRNA binding site [nucleotide binding]; other site
595495008944	predicted 30S ribosome binding site; other site
595495008945	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
595495008946	Clp amino terminal domain; Region: Clp_N; pfam02861
595495008947	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495008948	Walker A motif; other site
595495008949	ATP binding site [chemical binding]; other site
595495008950	Walker B motif; other site
595495008951	arginine finger; other site
595495008952	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495008953	Walker A motif; other site
595495008954	ATP binding site [chemical binding]; other site
595495008955	Walker B motif; other site
595495008956	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
595495008957	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
595495008958	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
595495008959	DNA-binding site [nucleotide binding]; DNA binding site
595495008960	RNA-binding motif; other site
595495008961	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
595495008962	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
595495008963	Walker A/P-loop; other site
595495008964	ATP binding site [chemical binding]; other site
595495008965	Q-loop/lid; other site
595495008966	ABC transporter signature motif; other site
595495008967	Walker B; other site
595495008968	D-loop; other site
595495008969	H-loop/switch region; other site
595495008970	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
595495008971	FtsX-like permease family; Region: FtsX; pfam02687
595495008972	macrolide transporter subunit MacA; Provisional; Region: PRK11578
595495008973	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
595495008974	HlyD family secretion protein; Region: HlyD_3; pfam13437
595495008975	Protein of unknown function (DUF535); Region: DUF535; pfam04393
595495008976	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
595495008977	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
595495008978	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
595495008979	putative active site [active]
595495008980	putative metal-binding site [ion binding]; other site
595495008981	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
595495008982	amphipathic channel; other site
595495008983	Asn-Pro-Ala signature motifs; other site
595495008984	Predicted membrane protein [Function unknown]; Region: COG2431
595495008985	hybrid cluster protein; Provisional; Region: PRK05290
595495008986	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
595495008987	ACS interaction site; other site
595495008988	CODH interaction site; other site
595495008989	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
595495008990	hybrid metal cluster; other site
595495008991	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
595495008992	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
595495008993	FAD binding pocket [chemical binding]; other site
595495008994	FAD binding motif [chemical binding]; other site
595495008995	phosphate binding motif [ion binding]; other site
595495008996	beta-alpha-beta structure motif; other site
595495008997	NAD binding pocket [chemical binding]; other site
595495008998	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
595495008999	catalytic loop [active]
595495009000	iron binding site [ion binding]; other site
595495009001	pyruvate dehydrogenase; Provisional; Region: PRK09124
595495009002	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
595495009003	PYR/PP interface [polypeptide binding]; other site
595495009004	dimer interface [polypeptide binding]; other site
595495009005	tetramer interface [polypeptide binding]; other site
595495009006	TPP binding site [chemical binding]; other site
595495009007	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
595495009008	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
595495009009	TPP-binding site [chemical binding]; other site
595495009010	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
595495009011	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
595495009012	tetramer interface [polypeptide binding]; other site
595495009013	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495009014	catalytic residue [active]
595495009015	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
595495009016	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
595495009017	putative NAD(P) binding site [chemical binding]; other site
595495009018	putative active site [active]
595495009019	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
595495009020	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
595495009021	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
595495009022	NAD(P) binding site [chemical binding]; other site
595495009023	active site
595495009024	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
595495009025	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
595495009026	amidase catalytic site [active]
595495009027	Zn binding residues [ion binding]; other site
595495009028	substrate binding site [chemical binding]; other site
595495009029	hypothetical protein; Provisional; Region: PRK02877
595495009030	putative lipoprotein; Provisional; Region: PRK10533
595495009031	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
595495009032	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495009033	Walker A/P-loop; other site
595495009034	ATP binding site [chemical binding]; other site
595495009035	Q-loop/lid; other site
595495009036	ABC transporter signature motif; other site
595495009037	Walker B; other site
595495009038	D-loop; other site
595495009039	H-loop/switch region; other site
595495009040	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
595495009041	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
595495009042	substrate binding pocket [chemical binding]; other site
595495009043	membrane-bound complex binding site; other site
595495009044	hinge residues; other site
595495009045	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
595495009046	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495009047	dimer interface [polypeptide binding]; other site
595495009048	conserved gate region; other site
595495009049	putative PBP binding loops; other site
595495009050	ABC-ATPase subunit interface; other site
595495009051	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495009052	dimer interface [polypeptide binding]; other site
595495009053	conserved gate region; other site
595495009054	putative PBP binding loops; other site
595495009055	ABC-ATPase subunit interface; other site
595495009056	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
595495009057	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
595495009058	substrate binding pocket [chemical binding]; other site
595495009059	membrane-bound complex binding site; other site
595495009060	hinge residues; other site
595495009061	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
595495009062	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495009063	S-adenosylmethionine binding site [chemical binding]; other site
595495009064	Protein of unknown function (DUF2593); Region: DUF2593; pfam10767
595495009065	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
595495009066	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495009067	dimer interface [polypeptide binding]; other site
595495009068	conserved gate region; other site
595495009069	putative PBP binding loops; other site
595495009070	ABC-ATPase subunit interface; other site
595495009071	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
595495009072	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495009073	dimer interface [polypeptide binding]; other site
595495009074	conserved gate region; other site
595495009075	putative PBP binding loops; other site
595495009076	ABC-ATPase subunit interface; other site
595495009077	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
595495009078	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495009079	Walker A/P-loop; other site
595495009080	ATP binding site [chemical binding]; other site
595495009081	Q-loop/lid; other site
595495009082	ABC transporter signature motif; other site
595495009083	Walker B; other site
595495009084	D-loop; other site
595495009085	H-loop/switch region; other site
595495009086	TOBE domain; Region: TOBE_2; pfam08402
595495009087	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
595495009088	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
595495009089	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
595495009090	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
595495009091	RimK-like ATP-grasp domain; Region: RimK; pfam08443
595495009092	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
595495009093	dimer interface [polypeptide binding]; other site
595495009094	FMN binding site [chemical binding]; other site
595495009095	NADPH bind site [chemical binding]; other site
595495009096	Protein of unknown function (DUF1418); Region: DUF1418; pfam07214
595495009097	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
595495009098	GSH binding site [chemical binding]; other site
595495009099	catalytic residues [active]
595495009100	Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045
595495009101	putative transporter; Provisional; Region: PRK04972
595495009102	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
595495009103	TrkA-C domain; Region: TrkA_C; pfam02080
595495009104	TrkA-C domain; Region: TrkA_C; pfam02080
595495009105	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
595495009106	DNA-binding transcriptional regulator; Provisional; Region: PRK09678
595495009107	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
595495009108	tail protein; Provisional; Region: D; PHA02561
595495009109	Phage protein U [General function prediction only]; Region: COG3499
595495009110	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
595495009111	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
595495009112	major tail tube protein; Provisional; Region: FII; PHA02600
595495009113	major tail sheath protein; Provisional; Region: FI; PHA02560
595495009114	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
595495009115	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
595495009116	catalytic residues [active]
595495009117	catalytic nucleophile [active]
595495009118	Presynaptic Site I dimer interface [polypeptide binding]; other site
595495009119	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
595495009120	Synaptic Flat tetramer interface [polypeptide binding]; other site
595495009121	Synaptic Site I dimer interface [polypeptide binding]; other site
595495009122	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
595495009123	DNA-binding interface [nucleotide binding]; DNA binding site
595495009124	Phage Tail Collar Domain; Region: Collar; pfam07484
595495009125	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
595495009126	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
595495009127	Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385
595495009128	baseplate assembly protein; Provisional; Region: J; PHA02568
595495009129	baseplate wedge subunit; Provisional; Region: W; PHA02516
595495009130	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
595495009131	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
595495009132	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
595495009133	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
595495009134	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
595495009135	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
595495009136	catalytic residues [active]
595495009137	P2-like prophage tail protein X [General function prediction only]; Region: COG5004
595495009138	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
595495009139	terminase endonuclease subunit; Provisional; Region: M; PHA02537
595495009140	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
595495009141	capsid protein; Provisional; Region: N; PHA02538
595495009142	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929
595495009143	terminase ATPase subunit; Provisional; Region: P; PHA02535
595495009144	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
595495009145	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
595495009146	portal vertex protein; Provisional; Region: Q; PHA02536
595495009147	Phage portal protein; Region: Phage_portal; pfam04860
595495009148	Protein of unknown function DUF262; Region: DUF262; pfam03235
595495009149	Uncharacterized conserved protein [Function unknown]; Region: COG1479
595495009150	DinI-like family; Region: DinI; pfam06183
595495009151	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
595495009152	DNA adenine methylase (dam); Region: dam; TIGR00571
595495009153	DksA-like zinc finger domain containing protein; Region: PHA00080
595495009154	Protein of unknown function (DUF2732); Region: DUF2732; pfam10809
595495009155	Protein of unknown function (DUF2724); Region: DUF2724; pfam10893
595495009156	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
595495009157	Helix-turn-helix domain; Region: HTH_17; cl17695
595495009158	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
595495009159	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
595495009160	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
595495009161	integrase; Provisional; Region: int; PHA02601
595495009162	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
595495009163	active site
595495009164	DNA binding site [nucleotide binding]
595495009165	Int/Topo IB signature motif; other site
595495009166	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
595495009167	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
595495009168	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
595495009169	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495009170	putative substrate translocation pore; other site
595495009171	Major Facilitator Superfamily; Region: MFS_1; pfam07690
595495009172	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
595495009173	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495009174	active site
595495009175	motif I; other site
595495009176	motif II; other site
595495009177	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495009178	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
595495009179	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
595495009180	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495009181	putative substrate translocation pore; other site
595495009182	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
595495009183	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
595495009184	active site
595495009185	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
595495009186	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
595495009187	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
595495009188	D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001
595495009189	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
595495009190	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
595495009191	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
595495009192	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
595495009193	putative C-terminal domain interface [polypeptide binding]; other site
595495009194	putative GSH binding site (G-site) [chemical binding]; other site
595495009195	putative dimer interface [polypeptide binding]; other site
595495009196	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
595495009197	N-terminal domain interface [polypeptide binding]; other site
595495009198	dimer interface [polypeptide binding]; other site
595495009199	substrate binding pocket (H-site) [chemical binding]; other site
595495009200	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
595495009201	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
595495009202	biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302
595495009203	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
595495009204	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
595495009205	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
595495009206	FeS/SAM binding site; other site
595495009207	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
595495009208	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
595495009209	metal binding site [ion binding]; metal-binding site
595495009210	active site
595495009211	I-site; other site
595495009212	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
595495009213	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
595495009214	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
595495009215	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495009216	dimer interface [polypeptide binding]; other site
595495009217	conserved gate region; other site
595495009218	putative PBP binding loops; other site
595495009219	ABC-ATPase subunit interface; other site
595495009220	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
595495009221	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495009222	dimer interface [polypeptide binding]; other site
595495009223	conserved gate region; other site
595495009224	putative PBP binding loops; other site
595495009225	ABC-ATPase subunit interface; other site
595495009226	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
595495009227	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
595495009228	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
595495009229	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
595495009230	Walker A/P-loop; other site
595495009231	ATP binding site [chemical binding]; other site
595495009232	Q-loop/lid; other site
595495009233	ABC transporter signature motif; other site
595495009234	Walker B; other site
595495009235	D-loop; other site
595495009236	H-loop/switch region; other site
595495009237	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
595495009238	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
595495009239	Walker A/P-loop; other site
595495009240	ATP binding site [chemical binding]; other site
595495009241	Q-loop/lid; other site
595495009242	ABC transporter signature motif; other site
595495009243	Walker B; other site
595495009244	D-loop; other site
595495009245	H-loop/switch region; other site
595495009246	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
595495009247	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
595495009248	catalytic nucleophile [active]
595495009249	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
595495009250	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
595495009251	dimer interface [polypeptide binding]; other site
595495009252	putative functional site; other site
595495009253	putative MPT binding site; other site
595495009254	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
595495009255	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
595495009256	ATP binding site [chemical binding]; other site
595495009257	substrate interface [chemical binding]; other site
595495009258	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
595495009259	active site
595495009260	intersubunit interactions; other site
595495009261	catalytic residue [active]
595495009262	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
595495009263	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
595495009264	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
595495009265	dimer interface [polypeptide binding]; other site
595495009266	active site
595495009267	glycine loop; other site
595495009268	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
595495009269	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495009270	active site
595495009271	motif I; other site
595495009272	motif II; other site
595495009273	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495009274	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
595495009275	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
595495009276	Transposase; Region: DEDD_Tnp_IS110; pfam01548
595495009277	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
595495009278	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
595495009279	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495009280	Walker A/P-loop; other site
595495009281	ATP binding site [chemical binding]; other site
595495009282	Q-loop/lid; other site
595495009283	ABC transporter signature motif; other site
595495009284	Walker B; other site
595495009285	D-loop; other site
595495009286	H-loop/switch region; other site
595495009287	ABC transporter; Region: ABC_tran_2; pfam12848
595495009288	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
595495009289	L,D-transpeptidase; Provisional; Region: PRK10260
595495009290	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
595495009291	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
595495009292	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
595495009293	transmembrane helices; other site
595495009294	manganese transport regulator MntR; Provisional; Region: PRK11050
595495009295	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
595495009296	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
595495009297	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
595495009298	Sulfatase; Region: Sulfatase; pfam00884
595495009299	outer membrane protein X; Provisional; Region: ompX; PRK09408
595495009300	threonine and homoserine efflux system; Provisional; Region: PRK10532
595495009301	EamA-like transporter family; Region: EamA; pfam00892
595495009302	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
595495009303	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
595495009304	dimerization interface [polypeptide binding]; other site
595495009305	DPS ferroxidase diiron center [ion binding]; other site
595495009306	ion pore; other site
595495009307	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
595495009308	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
595495009309	substrate binding pocket [chemical binding]; other site
595495009310	membrane-bound complex binding site; other site
595495009311	hinge residues; other site
595495009312	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
595495009313	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495009314	dimer interface [polypeptide binding]; other site
595495009315	conserved gate region; other site
595495009316	putative PBP binding loops; other site
595495009317	ABC-ATPase subunit interface; other site
595495009318	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
595495009319	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
595495009320	Walker A/P-loop; other site
595495009321	ATP binding site [chemical binding]; other site
595495009322	Q-loop/lid; other site
595495009323	ABC transporter signature motif; other site
595495009324	Walker B; other site
595495009325	D-loop; other site
595495009326	H-loop/switch region; other site
595495009327	putative mechanosensitive channel protein; Provisional; Region: PRK11465
595495009328	Mechanosensitive ion channel; Region: MS_channel; pfam00924
595495009329	23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727
595495009330	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
595495009331	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
595495009332	catecholate siderophore receptor Fiu; Provisional; Region: PRK09840
595495009333	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
595495009334	N-terminal plug; other site
595495009335	ligand-binding site [chemical binding]; other site
595495009336	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
595495009337	hypothetical protein; Provisional; Region: PRK11019
595495009338	hypothetical protein; Provisional; Region: PRK10259
595495009339	putative dehydrogenase; Provisional; Region: PRK10098
595495009340	glycosyl transferase family protein; Provisional; Region: PRK08136
595495009341	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
595495009342	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
595495009343	DEAD_2; Region: DEAD_2; pfam06733
595495009344	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
595495009345	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236
595495009346	helicase 45; Provisional; Region: PTZ00424
595495009347	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
595495009348	ATP binding site [chemical binding]; other site
595495009349	Mg++ binding site [ion binding]; other site
595495009350	motif III; other site
595495009351	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
595495009352	nucleotide binding region [chemical binding]; other site
595495009353	ATP-binding site [chemical binding]; other site
595495009354	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
595495009355	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
595495009356	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
595495009357	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
595495009358	HlyD family secretion protein; Region: HlyD_3; pfam13437
595495009359	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
595495009360	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
595495009361	Walker A/P-loop; other site
595495009362	ATP binding site [chemical binding]; other site
595495009363	Q-loop/lid; other site
595495009364	ABC transporter signature motif; other site
595495009365	Walker B; other site
595495009366	D-loop; other site
595495009367	H-loop/switch region; other site
595495009368	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
595495009369	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
595495009370	Walker A/P-loop; other site
595495009371	ATP binding site [chemical binding]; other site
595495009372	Q-loop/lid; other site
595495009373	ABC transporter signature motif; other site
595495009374	Walker B; other site
595495009375	D-loop; other site
595495009376	H-loop/switch region; other site
595495009377	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
595495009378	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
595495009379	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
595495009380	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
595495009381	Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076
595495009382	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
595495009383	putative catalytic site [active]
595495009384	putative metal binding site [ion binding]; other site
595495009385	putative phosphate binding site [ion binding]; other site
595495009386	cardiolipin synthase 2; Provisional; Region: PRK11263
595495009387	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
595495009388	putative active site [active]
595495009389	catalytic site [active]
595495009390	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
595495009391	putative active site [active]
595495009392	catalytic site [active]
595495009393	Predicted integral membrane protein [Function unknown]; Region: COG0392
595495009394	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
595495009395	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
595495009396	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
595495009397	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
595495009398	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
595495009399	MoaE homodimer interface [polypeptide binding]; other site
595495009400	MoaD interaction [polypeptide binding]; other site
595495009401	active site residues [active]
595495009402	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
595495009403	MoaE interaction surface [polypeptide binding]; other site
595495009404	MoeB interaction surface [polypeptide binding]; other site
595495009405	thiocarboxylated glycine; other site
595495009406	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
595495009407	trimer interface [polypeptide binding]; other site
595495009408	dimer interface [polypeptide binding]; other site
595495009409	putative active site [active]
595495009410	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
595495009411	MPT binding site; other site
595495009412	trimer interface [polypeptide binding]; other site
595495009413	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
595495009414	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
595495009415	FeS/SAM binding site; other site
595495009416	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
595495009417	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
595495009418	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
595495009419	putative substrate binding pocket [chemical binding]; other site
595495009420	dimer interface [polypeptide binding]; other site
595495009421	phosphate binding site [ion binding]; other site
595495009422	excinuclease ABC subunit B; Provisional; Region: PRK05298
595495009423	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
595495009424	ATP binding site [chemical binding]; other site
595495009425	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
595495009426	nucleotide binding region [chemical binding]; other site
595495009427	ATP-binding site [chemical binding]; other site
595495009428	Ultra-violet resistance protein B; Region: UvrB; pfam12344
595495009429	UvrB/uvrC motif; Region: UVR; pfam02151
595495009430	AAA domain; Region: AAA_26; pfam13500
595495009431	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
595495009432	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
595495009433	ADP binding site [chemical binding]; other site
595495009434	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
595495009435	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495009436	S-adenosylmethionine binding site [chemical binding]; other site
595495009437	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
595495009438	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
595495009439	substrate-cofactor binding pocket; other site
595495009440	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495009441	catalytic residue [active]
595495009442	biotin synthase; Provisional; Region: PRK15108
595495009443	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
595495009444	FeS/SAM binding site; other site
595495009445	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
595495009446	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
595495009447	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
595495009448	inhibitor-cofactor binding pocket; inhibition site
595495009449	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495009450	catalytic residue [active]
595495009451	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
595495009452	substrate binding site [chemical binding]; other site
595495009453	acyl-CoA thioesterase; Provisional; Region: PRK10531
595495009454	putative pectinesterase; Region: PLN02432; cl01911
595495009455	putative hydratase; Provisional; Region: PRK11413
595495009456	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
595495009457	substrate binding site [chemical binding]; other site
595495009458	ligand binding site [chemical binding]; other site
595495009459	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
595495009460	substrate binding site [chemical binding]; other site
595495009461	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
595495009462	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
595495009463	transmembrane helices; other site
595495009464	PrpF protein; Region: PrpF; pfam04303
595495009465	Transcriptional regulator [Transcription]; Region: LysR; COG0583
595495009466	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495009467	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
595495009468	putative dimerization interface [polypeptide binding]; other site
595495009469	6-phosphogluconolactonase; Provisional; Region: PRK11028
595495009470	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
595495009471	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495009472	motif II; other site
595495009473	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495009474	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
595495009475	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495009476	Walker A/P-loop; other site
595495009477	ATP binding site [chemical binding]; other site
595495009478	Q-loop/lid; other site
595495009479	ABC transporter signature motif; other site
595495009480	Walker B; other site
595495009481	D-loop; other site
595495009482	H-loop/switch region; other site
595495009483	molybdenum-pterin binding domain; Region: Mop; TIGR00638
595495009484	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
595495009485	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495009486	putative PBP binding loops; other site
595495009487	ABC-ATPase subunit interface; other site
595495009488	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
595495009489	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
595495009490	substrate binding pocket [chemical binding]; other site
595495009491	membrane-bound complex binding site; other site
595495009492	hinge residues; other site
595495009493	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
595495009494	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
595495009495	molybdenum-pterin binding domain; Region: Mop; TIGR00638
595495009496	TOBE domain; Region: TOBE; pfam03459
595495009497	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
595495009498	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
595495009499	Walker A/P-loop; other site
595495009500	ATP binding site [chemical binding]; other site
595495009501	Q-loop/lid; other site
595495009502	ABC transporter signature motif; other site
595495009503	Walker B; other site
595495009504	D-loop; other site
595495009505	H-loop/switch region; other site
595495009506	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495009507	Walker A/P-loop; other site
595495009508	ATP binding site [chemical binding]; other site
595495009509	Q-loop/lid; other site
595495009510	ABC transporter signature motif; other site
595495009511	Walker B; other site
595495009512	D-loop; other site
595495009513	H-loop/switch region; other site
595495009514	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
595495009515	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
595495009516	NAD binding site [chemical binding]; other site
595495009517	homodimer interface [polypeptide binding]; other site
595495009518	active site
595495009519	substrate binding site [chemical binding]; other site
595495009520	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
595495009521	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
595495009522	dimer interface [polypeptide binding]; other site
595495009523	active site
595495009524	galactokinase; Provisional; Region: PRK05101
595495009525	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
595495009526	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
595495009527	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
595495009528	active site
595495009529	catalytic residues [active]
595495009530	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
595495009531	catalytic core [active]
595495009532	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
595495009533	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
595495009534	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
595495009535	YbgS-like protein; Region: YbgS; pfam13985
595495009536	zinc transporter ZitB; Provisional; Region: PRK03557
595495009537	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
595495009538	quinolinate synthetase; Provisional; Region: PRK09375
595495009539	tol-pal system protein YbgF; Provisional; Region: PRK10803
595495009540	Tetratricopeptide repeat; Region: TPR_6; pfam13174
595495009541	Tetratricopeptide repeat; Region: TPR_6; pfam13174
595495009542	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
595495009543	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
595495009544	ligand binding site [chemical binding]; other site
595495009545	translocation protein TolB; Provisional; Region: tolB; PRK03629
595495009546	TolB amino-terminal domain; Region: TolB_N; pfam04052
595495009547	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
595495009548	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
595495009549	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
595495009550	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
595495009551	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
595495009552	TolA C-terminal; Region: TolA; pfam06519
595495009553	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
595495009554	colicin uptake protein TolR; Provisional; Region: PRK11024
595495009555	colicin uptake protein TolQ; Provisional; Region: PRK10801
595495009556	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
595495009557	active site
595495009558	hypothetical protein; Provisional; Region: PRK10588
595495009559	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
595495009560	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003
595495009561	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
595495009562	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
595495009563	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
595495009564	alpha-mannosidase; Provisional; Region: PRK09819
595495009565	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
595495009566	active site
595495009567	metal binding site [ion binding]; metal-binding site
595495009568	catalytic site [active]
595495009569	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
595495009570	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
595495009571	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
595495009572	active site
595495009573	phosphorylation site [posttranslational modification]
595495009574	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
595495009575	active site
595495009576	P-loop; other site
595495009577	phosphorylation site [posttranslational modification]
595495009578	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
595495009579	DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764
595495009580	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495009581	DNA-binding site [nucleotide binding]; DNA binding site
595495009582	UTRA domain; Region: UTRA; pfam07702
595495009583	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
595495009584	CoA binding domain; Region: CoA_binding; smart00881
595495009585	CoA-ligase; Region: Ligase_CoA; pfam00549
595495009586	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
595495009587	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
595495009588	CoA-ligase; Region: Ligase_CoA; pfam00549
595495009589	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
595495009590	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
595495009591	E3 interaction surface; other site
595495009592	lipoyl attachment site [posttranslational modification]; other site
595495009593	e3 binding domain; Region: E3_binding; pfam02817
595495009594	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
595495009595	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
595495009596	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
595495009597	TPP-binding site [chemical binding]; other site
595495009598	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
595495009599	dimer interface [polypeptide binding]; other site
595495009600	PYR/PP interface [polypeptide binding]; other site
595495009601	TPP binding site [chemical binding]; other site
595495009602	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
595495009603	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
595495009604	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
595495009605	L-aspartate oxidase; Provisional; Region: PRK06175
595495009606	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
595495009607	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
595495009608	SdhC subunit interface [polypeptide binding]; other site
595495009609	proximal heme binding site [chemical binding]; other site
595495009610	cardiolipin binding site; other site
595495009611	Iron-sulfur protein interface; other site
595495009612	proximal quinone binding site [chemical binding]; other site
595495009613	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
595495009614	Iron-sulfur protein interface; other site
595495009615	proximal quinone binding site [chemical binding]; other site
595495009616	SdhD (CybS) interface [polypeptide binding]; other site
595495009617	proximal heme binding site [chemical binding]; other site
595495009618	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
595495009619	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
595495009620	dimer interface [polypeptide binding]; other site
595495009621	active site
595495009622	citrylCoA binding site [chemical binding]; other site
595495009623	NADH binding [chemical binding]; other site
595495009624	cationic pore residues; other site
595495009625	oxalacetate/citrate binding site [chemical binding]; other site
595495009626	coenzyme A binding site [chemical binding]; other site
595495009627	catalytic triad [active]
595495009628	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
595495009629	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
595495009630	PapC N-terminal domain; Region: PapC_N; pfam13954
595495009631	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
595495009632	PapC C-terminal domain; Region: PapC_C; pfam13953
595495009633	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
595495009634	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
595495009635	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
595495009636	Fimbrial protein; Region: Fimbrial; pfam00419
595495009637	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
595495009638	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
595495009639	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
595495009640	endonuclease VIII; Provisional; Region: PRK10445
595495009641	N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965
595495009642	DNA binding site [nucleotide binding]
595495009643	catalytic residue [active]
595495009644	putative catalytic residues [active]
595495009645	H2TH interface [polypeptide binding]; other site
595495009646	intercalation triad [nucleotide binding]; other site
595495009647	substrate specificity determining residue; other site
595495009648	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
595495009649	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
595495009650	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
595495009651	putative active site [active]
595495009652	biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724
595495009653	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
595495009654	sensor histidine kinase inhibitor, KipI family; Region: TIGR00370
595495009655	Uncharacterized conserved protein [Function unknown]; Region: COG0327
595495009656	metal-binding protein; Provisional; Region: PRK10799
595495009657	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
595495009658	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495009659	putative substrate translocation pore; other site
595495009660	POT family; Region: PTR2; pfam00854
595495009661	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
595495009662	DNA photolyase; Region: DNA_photolyase; pfam00875
595495009663	hypothetical protein; Provisional; Region: PRK10167
595495009664	Uncharacterized conserved protein [Function unknown]; Region: COG3272
595495009665	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
595495009666	RHS protein; Region: RHS; pfam03527
595495009667	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
595495009668	PAAR motif; Region: PAAR_motif; cl15808
595495009669	RHS Repeat; Region: RHS_repeat; pfam05593
595495009670	RHS Repeat; Region: RHS_repeat; pfam05593
595495009671	RHS Repeat; Region: RHS_repeat; cl11982
595495009672	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
595495009673	RHS Repeat; Region: RHS_repeat; pfam05593
595495009674	RHS Repeat; Region: RHS_repeat; pfam05593
595495009675	RHS protein; Region: RHS; pfam03527
595495009676	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
595495009677	Protein of unknown function (DUF2517); Region: DUF2517; pfam10725
595495009678	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
595495009679	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
595495009680	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
595495009681	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
595495009682	sensor protein KdpD; Provisional; Region: PRK10490
595495009683	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
595495009684	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
595495009685	Ligand Binding Site [chemical binding]; other site
595495009686	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
595495009687	GAF domain; Region: GAF_3; pfam13492
595495009688	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
595495009689	dimer interface [polypeptide binding]; other site
595495009690	phosphorylation site [posttranslational modification]
595495009691	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495009692	ATP binding site [chemical binding]; other site
595495009693	Mg2+ binding site [ion binding]; other site
595495009694	G-X-G motif; other site
595495009695	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
595495009696	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495009697	active site
595495009698	phosphorylation site [posttranslational modification]
595495009699	intermolecular recognition site; other site
595495009700	dimerization interface [polypeptide binding]; other site
595495009701	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
595495009702	DNA binding site [nucleotide binding]
595495009703	Protein of unknown function (DUF2618); Region: DUF2618; pfam10940
595495009704	ornithine decarboxylase; Provisional; Region: PRK13578
595495009705	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
595495009706	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
595495009707	homodimer interface [polypeptide binding]; other site
595495009708	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495009709	catalytic residue [active]
595495009710	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
595495009711	putrescine transporter; Provisional; Region: potE; PRK10655
595495009712	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
595495009713	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
595495009714	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
595495009715	active site
595495009716	substrate binding site [chemical binding]; other site
595495009717	metal binding site [ion binding]; metal-binding site
595495009718	replication initiation regulator SeqA; Provisional; Region: PRK11187
595495009719	acyl-CoA esterase; Provisional; Region: PRK10673
595495009720	PGAP1-like protein; Region: PGAP1; pfam07819
595495009721	LexA regulated protein; Provisional; Region: PRK11675
595495009722	flavodoxin FldA; Validated; Region: PRK09267
595495009723	ferric uptake regulator; Provisional; Region: fur; PRK09462
595495009724	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
595495009725	metal binding site 2 [ion binding]; metal-binding site
595495009726	putative DNA binding helix; other site
595495009727	metal binding site 1 [ion binding]; metal-binding site
595495009728	dimer interface [polypeptide binding]; other site
595495009729	structural Zn2+ binding site [ion binding]; other site
595495009730	YbfN-like lipoprotein; Region: YbfN; pfam13982
595495009731	outer membrane porin, OprD family; Region: OprD; pfam03573
595495009732	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
595495009733	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
595495009734	active site
595495009735	HIGH motif; other site
595495009736	nucleotide binding site [chemical binding]; other site
595495009737	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
595495009738	KMSKS motif; other site
595495009739	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
595495009740	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
595495009741	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
595495009742	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
595495009743	active site turn [active]
595495009744	phosphorylation site [posttranslational modification]
595495009745	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
595495009746	HPr interaction site; other site
595495009747	glycerol kinase (GK) interaction site [polypeptide binding]; other site
595495009748	active site
595495009749	phosphorylation site [posttranslational modification]
595495009750	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
595495009751	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
595495009752	active site
595495009753	trimer interface [polypeptide binding]; other site
595495009754	allosteric site; other site
595495009755	active site lid [active]
595495009756	hexamer (dimer of trimers) interface [polypeptide binding]; other site
595495009757	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
595495009758	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
595495009759	active site
595495009760	dimer interface [polypeptide binding]; other site
595495009761	MarR family; Region: MarR; pfam01047
595495009762	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
595495009763	ROK family; Region: ROK; pfam00480
595495009764	UMP phosphatase; Provisional; Region: PRK10444
595495009765	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495009766	active site
595495009767	motif I; other site
595495009768	motif II; other site
595495009769	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495009770	asparagine synthetase B; Provisional; Region: asnB; PRK09431
595495009771	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
595495009772	active site
595495009773	dimer interface [polypeptide binding]; other site
595495009774	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
595495009775	Ligand Binding Site [chemical binding]; other site
595495009776	Molecular Tunnel; other site
595495009777	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
595495009778	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
595495009779	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
595495009780	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
595495009781	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
595495009782	FeS/SAM binding site; other site
595495009783	TRAM domain; Region: TRAM; pfam01938
595495009784	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
595495009785	PhoH-like protein; Region: PhoH; pfam02562
595495009786	metal-binding heat shock protein; Provisional; Region: PRK00016
595495009787	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
595495009788	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
595495009789	Transporter associated domain; Region: CorC_HlyC; smart01091
595495009790	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
595495009791	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
595495009792	putative active site [active]
595495009793	catalytic triad [active]
595495009794	putative dimer interface [polypeptide binding]; other site
595495009795	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
595495009796	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
595495009797	substrate binding pocket [chemical binding]; other site
595495009798	membrane-bound complex binding site; other site
595495009799	hinge residues; other site
595495009800	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
595495009801	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495009802	dimer interface [polypeptide binding]; other site
595495009803	conserved gate region; other site
595495009804	putative PBP binding loops; other site
595495009805	ABC-ATPase subunit interface; other site
595495009806	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
595495009807	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495009808	dimer interface [polypeptide binding]; other site
595495009809	conserved gate region; other site
595495009810	putative PBP binding loops; other site
595495009811	ABC-ATPase subunit interface; other site
595495009812	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
595495009813	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
595495009814	Walker A/P-loop; other site
595495009815	ATP binding site [chemical binding]; other site
595495009816	Q-loop/lid; other site
595495009817	ABC transporter signature motif; other site
595495009818	Walker B; other site
595495009819	D-loop; other site
595495009820	H-loop/switch region; other site
595495009821	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
595495009822	active site
595495009823	tetramer interface [polypeptide binding]; other site
595495009824	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
595495009825	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
595495009826	nucleotide binding site [chemical binding]; other site
595495009827	putative NEF/HSP70 interaction site [polypeptide binding]; other site
595495009828	SBD interface [polypeptide binding]; other site
595495009829	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
595495009830	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
595495009831	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
595495009832	Sel1-like repeats; Region: SEL1; smart00671
595495009833	Sel1-like repeats; Region: SEL1; smart00671
595495009834	Sel1-like repeats; Region: SEL1; smart00671
595495009835	DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271
595495009836	HSP70 interaction site [polypeptide binding]; other site
595495009837	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
595495009838	Sel1-like repeats; Region: SEL1; smart00671
595495009839	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
595495009840	Sel1-like repeats; Region: SEL1; smart00671
595495009841	Sel1-like repeats; Region: SEL1; smart00671
595495009842	Sel1-like repeats; Region: SEL1; smart00671
595495009843	Sel1-like repeats; Region: SEL1; smart00671
595495009844	Sel1-like repeats; Region: SEL1; smart00671
595495009845	Sel1-like repeats; Region: SEL1; smart00671
595495009846	hypothetical protein; Provisional; Region: PRK11032
595495009847	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
595495009848	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
595495009849	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
595495009850	HIGH motif; other site
595495009851	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
595495009852	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
595495009853	active site
595495009854	KMSKS motif; other site
595495009855	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
595495009856	tRNA binding surface [nucleotide binding]; other site
595495009857	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
595495009858	LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796
595495009859	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
595495009860	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
595495009861	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
595495009862	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
595495009863	active site
595495009864	(T/H)XGH motif; other site
595495009865	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
595495009866	catalytic core [active]
595495009867	ribosome-associated protein; Provisional; Region: PRK11538
595495009868	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
595495009869	penicillin-binding protein 2; Provisional; Region: PRK10795
595495009870	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
595495009871	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
595495009872	cell wall shape-determining protein; Provisional; Region: PRK10794
595495009873	rare lipoprotein A; Provisional; Region: PRK10672
595495009874	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
595495009875	Sporulation related domain; Region: SPOR; pfam05036
595495009876	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
595495009877	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
595495009878	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
595495009879	hypothetical protein; Provisional; Region: PRK04998
595495009880	lipoate-protein ligase B; Provisional; Region: PRK14342
595495009881	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
595495009882	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495009883	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
595495009884	substrate binding pocket [chemical binding]; other site
595495009885	dimerization interface [polypeptide binding]; other site
595495009886	lipoyl synthase; Provisional; Region: PRK05481
595495009887	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
595495009888	FeS/SAM binding site; other site
595495009889	twin arginine translocase protein E; Validated; Region: tatE; PRK03625
595495009890	Predicted amidohydrolase [General function prediction only]; Region: COG0388
595495009891	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
595495009892	putative active site [active]
595495009893	catalytic triad [active]
595495009894	putative dimer interface [polypeptide binding]; other site
595495009895	chromosome condensation membrane protein; Provisional; Region: PRK14196
595495009896	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
595495009897	DNA-binding site [nucleotide binding]; DNA binding site
595495009898	RNA-binding motif; other site
595495009899	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
595495009900	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
595495009901	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
595495009902	two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046
595495009903	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495009904	active site
595495009905	phosphorylation site [posttranslational modification]
595495009906	intermolecular recognition site; other site
595495009907	dimerization interface [polypeptide binding]; other site
595495009908	Transcriptional regulator; Region: CitT; pfam12431
595495009909	sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053
595495009910	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
595495009911	putative active site [active]
595495009912	heme pocket [chemical binding]; other site
595495009913	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495009914	ATP binding site [chemical binding]; other site
595495009915	Mg2+ binding site [ion binding]; other site
595495009916	G-X-G motif; other site
595495009917	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
595495009918	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
595495009919	putative active site [active]
595495009920	(T/H)XGH motif; other site
595495009921	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
595495009922	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
595495009923	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
595495009924	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
595495009925	triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096
595495009926	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
595495009927	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
595495009928	transmembrane helices; other site
595495009929	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
595495009930	B1 nucleotide binding pocket [chemical binding]; other site
595495009931	B2 nucleotide binding pocket [chemical binding]; other site
595495009932	CAS motifs; other site
595495009933	active site
595495009934	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
595495009935	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
595495009936	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
595495009937	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
595495009938	NAD binding site [chemical binding]; other site
595495009939	catalytic Zn binding site [ion binding]; other site
595495009940	structural Zn binding site [ion binding]; other site
595495009941	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
595495009942	Ligand Binding Site [chemical binding]; other site
595495009943	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
595495009944	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
595495009945	catalytic residue [active]
595495009946	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
595495009947	catalytic residues [active]
595495009948	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
595495009949	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
595495009950	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
595495009951	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
595495009952	dimer interface [polypeptide binding]; other site
595495009953	decamer (pentamer of dimers) interface [polypeptide binding]; other site
595495009954	catalytic triad [active]
595495009955	peroxidatic and resolving cysteines [active]
595495009956	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
595495009957	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
595495009958	dimerization domain [polypeptide binding]; other site
595495009959	dimer interface [polypeptide binding]; other site
595495009960	catalytic residues [active]
595495009961	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
595495009962	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495009963	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
595495009964	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
595495009965	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
595495009966	Active Sites [active]
595495009967	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
595495009968	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
595495009969	ParB-like nuclease domain; Region: ParBc; pfam02195
595495009970	methionine aminotransferase; Validated; Region: PRK09082
595495009971	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
595495009972	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495009973	homodimer interface [polypeptide binding]; other site
595495009974	catalytic residue [active]
595495009975	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
595495009976	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
595495009977	putative active site [active]
595495009978	metal binding site [ion binding]; metal-binding site
595495009979	Uncharacterized small protein [Function unknown]; Region: COG2879
595495009980	carbon starvation protein A; Provisional; Region: PRK15015
595495009981	Carbon starvation protein CstA; Region: CstA; pfam02554
595495009982	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
595495009983	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
595495009984	CoenzymeA binding site [chemical binding]; other site
595495009985	subunit interaction site [polypeptide binding]; other site
595495009986	PHB binding site; other site
595495009987	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
595495009988	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
595495009989	putative NAD(P) binding site [chemical binding]; other site
595495009990	active site
595495009991	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
595495009992	hydrophobic substrate binding pocket; other site
595495009993	Isochorismatase family; Region: Isochorismatase; pfam00857
595495009994	active site
595495009995	conserved cis-peptide bond; other site
595495009996	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
595495009997	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
595495009998	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
595495009999	acyl-activating enzyme (AAE) consensus motif; other site
595495010000	active site
595495010001	AMP binding site [chemical binding]; other site
595495010002	substrate binding site [chemical binding]; other site
595495010003	isochorismate synthase EntC; Provisional; Region: PRK15016
595495010004	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
595495010005	iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957
595495010006	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
595495010007	siderophore binding site; other site
595495010008	enterobactin exporter EntS; Provisional; Region: PRK10489
595495010009	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495010010	putative substrate translocation pore; other site
595495010011	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
595495010012	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
595495010013	ABC-ATPase subunit  interface; other site
595495010014	dimer interface [polypeptide binding]; other site
595495010015	putative PBP binding regions; other site
595495010016	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
595495010017	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
595495010018	ABC-ATPase subunit  interface; other site
595495010019	dimer interface [polypeptide binding]; other site
595495010020	putative PBP binding regions; other site
595495010021	iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253
595495010022	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
595495010023	Walker A/P-loop; other site
595495010024	ATP binding site [chemical binding]; other site
595495010025	Q-loop/lid; other site
595495010026	ABC transporter signature motif; other site
595495010027	Walker B; other site
595495010028	D-loop; other site
595495010029	H-loop/switch region; other site
595495010030	LPS O-antigen length regulator; Provisional; Region: PRK10381
595495010031	Chain length determinant protein; Region: Wzz; pfam02706
595495010032	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
595495010033	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
595495010034	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
595495010035	acyl-activating enzyme (AAE) consensus motif; other site
595495010036	AMP binding site [chemical binding]; other site
595495010037	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
595495010038	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
595495010039	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
595495010040	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
595495010041	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
595495010042	outer membrane receptor FepA; Provisional; Region: PRK13524
595495010043	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
595495010044	N-terminal plug; other site
595495010045	ligand-binding site [chemical binding]; other site
595495010046	phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251
595495010047	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
595495010048	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
595495010049	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
595495010050	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
595495010051	Protein of unknown function (DUF1158); Region: DUF1158; pfam06643
595495010052	hypothetical protein; Provisional; Region: PRK10250
595495010053	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
595495010054	dimer interface [polypeptide binding]; other site
595495010055	FMN binding site [chemical binding]; other site
595495010056	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
595495010057	Mechanosensitive ion channel; Region: MS_channel; pfam00924
595495010058	phenylalanine transporter; Provisional; Region: PRK10249
595495010059	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
595495010060	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
595495010061	HlyD family secretion protein; Region: HlyD_3; pfam13437
595495010062	periplasmic copper-binding protein; Provisional; Region: PRK09838
595495010063	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
595495010064	DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836
595495010065	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495010066	active site
595495010067	phosphorylation site [posttranslational modification]
595495010068	intermolecular recognition site; other site
595495010069	dimerization interface [polypeptide binding]; other site
595495010070	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
595495010071	DNA binding site [nucleotide binding]
595495010072	sensor kinase CusS; Provisional; Region: PRK09835
595495010073	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
595495010074	dimerization interface [polypeptide binding]; other site
595495010075	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
595495010076	dimer interface [polypeptide binding]; other site
595495010077	phosphorylation site [posttranslational modification]
595495010078	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495010079	ATP binding site [chemical binding]; other site
595495010080	Mg2+ binding site [ion binding]; other site
595495010081	G-X-G motif; other site
595495010082	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
595495010083	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
595495010084	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
595495010085	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
595495010086	Uncharacterized conserved protein [Function unknown]; Region: COG5435
595495010087	PAAR motif; Region: PAAR_motif; pfam05488
595495010088	RHS Repeat; Region: RHS_repeat; cl11982
595495010089	RHS Repeat; Region: RHS_repeat; pfam05593
595495010090	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
595495010091	RHS Repeat; Region: RHS_repeat; pfam05593
595495010092	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
595495010093	RHS Repeat; Region: RHS_repeat; pfam05593
595495010094	RHS Repeat; Region: RHS_repeat; cl11982
595495010095	RHS Repeat; Region: RHS_repeat; pfam05593
595495010096	RHS Repeat; Region: RHS_repeat; cl11982
595495010097	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
595495010098	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
595495010099	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
595495010100	RHS Repeat; Region: RHS_repeat; cl11982
595495010101	RHS Repeat; Region: RHS_repeat; cl11982
595495010102	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
595495010103	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
595495010104	RHS Repeat; Region: RHS_repeat; cl11982
595495010105	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
595495010106	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
595495010107	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
595495010108	Transposase [DNA replication, recombination, and repair]; Region: COG5433
595495010109	Transposase [DNA replication, recombination, and repair]; Region: COG5433
595495010110	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234
595495010111	active site
595495010112	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
595495010113	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
595495010114	bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782
595495010115	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
595495010116	TPR motif; other site
595495010117	binding surface
595495010118	Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283
595495010119	hypothetical protein; Provisional; Region: PRK09936
595495010120	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
595495010121	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495010122	transcriptional regulator FimZ; Provisional; Region: PRK09935
595495010123	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495010124	active site
595495010125	phosphorylation site [posttranslational modification]
595495010126	intermolecular recognition site; other site
595495010127	dimerization interface [polypeptide binding]; other site
595495010128	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
595495010129	DNA binding residues [nucleotide binding]
595495010130	dimerization interface [polypeptide binding]; other site
595495010131	fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934
595495010132	fimbrial-like adhesin; Provisional; Region: fimH; PRK15199
595495010133	fimbrial chaperone protein FimC; Provisional; Region: PRK15195
595495010134	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
595495010135	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
595495010136	type-1 fimbrial protein subunit A; Provisional; Region: PRK15194
595495010137	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
595495010138	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
595495010139	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
595495010140	homodimer interface [polypeptide binding]; other site
595495010141	NADP binding site [chemical binding]; other site
595495010142	substrate binding site [chemical binding]; other site
595495010143	ribosome-associated protein; Provisional; Region: PRK11507
595495010144	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
595495010145	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
595495010146	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
595495010147	active site
595495010148	HIGH motif; other site
595495010149	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
595495010150	KMSKS motif; other site
595495010151	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
595495010152	tRNA binding surface [nucleotide binding]; other site
595495010153	anticodon binding site; other site
595495010154	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
595495010155	substrate binding site [chemical binding]; other site
595495010156	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
595495010157	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
595495010158	putative active site [active]
595495010159	putative metal binding site [ion binding]; other site
595495010160	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
595495010161	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
595495010162	ATP-grasp domain; Region: ATP-grasp; pfam02222
595495010163	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
595495010164	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
595495010165	putative substrate binding site [chemical binding]; other site
595495010166	nucleotide binding site [chemical binding]; other site
595495010167	nucleotide binding site [chemical binding]; other site
595495010168	homodimer interface [polypeptide binding]; other site
595495010169	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
595495010170	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
595495010171	membrane protein FdrA; Validated; Region: PRK06091
595495010172	CoA binding domain; Region: CoA_binding; pfam02629
595495010173	CoA-ligase; Region: Ligase_CoA; pfam00549
595495010174	ureidoglycolate dehydrogenase; Provisional; Region: PRK15025
595495010175	allantoate amidohydrolase; Region: AllC; TIGR03176
595495010176	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
595495010177	active site
595495010178	metal binding site [ion binding]; metal-binding site
595495010179	dimer interface [polypeptide binding]; other site
595495010180	Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257
595495010181	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
595495010182	Cupin domain; Region: Cupin_2; cl17218
595495010183	glycerate kinase II; Provisional; Region: PRK09932
595495010184	putative uracil/xanthine transporter; Provisional; Region: PRK11412
595495010185	allantoinase; Provisional; Region: PRK08044
595495010186	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
595495010187	active site
595495010188	nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323
595495010189	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
595495010190	Na binding site [ion binding]; other site
595495010191	substrate binding site [chemical binding]; other site
595495010192	tartronate semialdehyde reductase; Provisional; Region: PRK15059
595495010193	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
595495010194	hydroxypyruvate isomerase; Provisional; Region: PRK09997
595495010195	glyoxylate carboligase; Provisional; Region: PRK11269
595495010196	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
595495010197	PYR/PP interface [polypeptide binding]; other site
595495010198	dimer interface [polypeptide binding]; other site
595495010199	TPP binding site [chemical binding]; other site
595495010200	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
595495010201	Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006
595495010202	TPP-binding site [chemical binding]; other site
595495010203	DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163
595495010204	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
595495010205	Bacterial transcriptional regulator; Region: IclR; pfam01614
595495010206	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
595495010207	ureidoglycolate hydrolase; Provisional; Region: PRK03606
595495010208	DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094
595495010209	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495010210	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
595495010211	dimerization interface [polypeptide binding]; other site
595495010212	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
595495010213	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
595495010214	active site residue [active]
595495010215	Winged helix-turn helix; Region: HTH_29; pfam13551
595495010216	Helix-turn-helix domain; Region: HTH_28; pfam13518
595495010217	hypothetical protein; Provisional; Region: PRK14710
595495010218	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
595495010219	RHS protein; Region: RHS; pfam03527
595495010220	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
595495010221	PAAR motif; Region: PAAR_motif; cl15808
595495010222	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
595495010223	RHS Repeat; Region: RHS_repeat; pfam05593
595495010224	RHS Repeat; Region: RHS_repeat; pfam05593
595495010225	RHS Repeat; Region: RHS_repeat; pfam05593
595495010226	RHS Repeat; Region: RHS_repeat; pfam05593
595495010227	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
595495010228	RHS Repeat; Region: RHS_repeat; pfam05593
595495010229	RHS Repeat; Region: RHS_repeat; pfam05593
595495010230	RHS protein; Region: RHS; pfam03527
595495010231	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
595495010232	Domain of unknown function (DUF4329); Region: DUF4329; pfam14220
595495010233	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
595495010234	FtsX-like permease family; Region: FtsX; pfam02687
595495010235	FtsX-like permease family; Region: FtsX; pfam02687
595495010236	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
595495010237	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
595495010238	Walker A/P-loop; other site
595495010239	ATP binding site [chemical binding]; other site
595495010240	Q-loop/lid; other site
595495010241	ABC transporter signature motif; other site
595495010242	Walker B; other site
595495010243	D-loop; other site
595495010244	H-loop/switch region; other site
595495010245	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
595495010246	active site
595495010247	catalytic triad [active]
595495010248	oxyanion hole [active]
595495010249	switch loop; other site
595495010250	oxidoreductase; Provisional; Region: PRK08017
595495010251	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
595495010252	NADP binding site [chemical binding]; other site
595495010253	active site
595495010254	steroid binding site; other site
595495010255	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
595495010256	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
595495010257	Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649
595495010258	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
595495010259	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495010260	Walker A/P-loop; other site
595495010261	ATP binding site [chemical binding]; other site
595495010262	Q-loop/lid; other site
595495010263	ABC transporter signature motif; other site
595495010264	Walker B; other site
595495010265	D-loop; other site
595495010266	H-loop/switch region; other site
595495010267	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
595495010268	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
595495010269	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
595495010270	DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227
595495010271	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
595495010272	DNA binding residues [nucleotide binding]
595495010273	dimer interface [polypeptide binding]; other site
595495010274	copper binding site [ion binding]; other site
595495010275	amino acid transporter; Region: 2A0306; TIGR00909
595495010276	glutaminase; Reviewed; Region: PRK12356
595495010277	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
595495010278	copper exporting ATPase; Provisional; Region: copA; PRK10671
595495010279	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
595495010280	metal-binding site [ion binding]
595495010281	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
595495010282	metal-binding site [ion binding]
595495010283	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
595495010284	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495010285	motif II; other site
595495010286	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
595495010287	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
595495010288	non-specific DNA binding site [nucleotide binding]; other site
595495010289	salt bridge; other site
595495010290	sequence-specific DNA binding site [nucleotide binding]; other site
595495010291	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
595495010292	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
595495010293	putative deacylase active site [active]
595495010294	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
595495010295	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
595495010296	active site
595495010297	metal binding site [ion binding]; metal-binding site
595495010298	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
595495010299	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495010300	Major Facilitator Superfamily; Region: MFS_1; pfam07690
595495010301	putative substrate translocation pore; other site
595495010302	putative cation:proton antiport protein; Provisional; Region: PRK10669
595495010303	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
595495010304	TrkA-N domain; Region: TrkA_N; pfam02254
595495010305	inosine/guanosine kinase; Provisional; Region: PRK15074
595495010306	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
595495010307	acetyl esterase; Provisional; Region: PRK10162
595495010308	ferrochelatase; Region: hemH; TIGR00109
595495010309	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
595495010310	C-terminal domain interface [polypeptide binding]; other site
595495010311	active site
595495010312	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
595495010313	active site
595495010314	N-terminal domain interface [polypeptide binding]; other site
595495010315	adenylate kinase; Reviewed; Region: adk; PRK00279
595495010316	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
595495010317	AMP-binding site [chemical binding]; other site
595495010318	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
595495010319	heat shock protein 90; Provisional; Region: PRK05218
595495010320	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495010321	ATP binding site [chemical binding]; other site
595495010322	Mg2+ binding site [ion binding]; other site
595495010323	G-X-G motif; other site
595495010324	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353
595495010325	RecR protein; Region: RecR; pfam02132
595495010326	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
595495010327	putative active site [active]
595495010328	putative metal-binding site [ion binding]; other site
595495010329	tetramer interface [polypeptide binding]; other site
595495010330	hypothetical protein; Validated; Region: PRK00153
595495010331	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
595495010332	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495010333	Walker A motif; other site
595495010334	ATP binding site [chemical binding]; other site
595495010335	Walker B motif; other site
595495010336	DNA polymerase III subunit delta'; Validated; Region: PRK08485
595495010337	arginine finger; other site
595495010338	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
595495010339	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
595495010340	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
595495010341	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
595495010342	active site
595495010343	hypothetical protein; Provisional; Region: PRK10527
595495010344	primosomal replication protein N''; Provisional; Region: PRK10093
595495010345	hypothetical protein; Provisional; Region: PRK11038
595495010346	hypothetical protein; Provisional; Region: PRK11281
595495010347	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
595495010348	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
595495010349	Mechanosensitive ion channel; Region: MS_channel; pfam00924
595495010350	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
595495010351	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
595495010352	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
595495010353	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
595495010354	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
595495010355	HlyD family secretion protein; Region: HlyD_3; pfam13437
595495010356	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
595495010357	Protein export membrane protein; Region: SecD_SecF; cl14618
595495010358	Protein export membrane protein; Region: SecD_SecF; cl14618
595495010359	Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757
595495010360	gene expression modulator; Provisional; Region: PRK10945
595495010361	maltose O-acetyltransferase; Provisional; Region: PRK10092
595495010362	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
595495010363	active site
595495010364	substrate binding site [chemical binding]; other site
595495010365	trimer interface [polypeptide binding]; other site
595495010366	CoA binding site [chemical binding]; other site
595495010367	sigma70 family sigma factor YlaC; Region: YlaC; pfam10777
595495010368	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
595495010369	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
595495010370	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
595495010371	Uncharacterized conserved protein [Function unknown]; Region: COG5507
595495010372	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
595495010373	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
595495010374	DNA binding site [nucleotide binding]
595495010375	active site
595495010376	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
595495010377	acyl-CoA thioesterase II; Provisional; Region: PRK10526
595495010378	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
595495010379	active site
595495010380	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
595495010381	catalytic triad [active]
595495010382	dimer interface [polypeptide binding]; other site
595495010383	ammonium transporter; Provisional; Region: PRK10666
595495010384	nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665
595495010385	Nitrogen regulatory protein P-II; Region: P-II; smart00938
595495010386	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
595495010387	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
595495010388	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
595495010389	Walker A/P-loop; other site
595495010390	ATP binding site [chemical binding]; other site
595495010391	Q-loop/lid; other site
595495010392	ABC transporter signature motif; other site
595495010393	Walker B; other site
595495010394	D-loop; other site
595495010395	H-loop/switch region; other site
595495010396	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
595495010397	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
595495010398	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495010399	Walker A/P-loop; other site
595495010400	ATP binding site [chemical binding]; other site
595495010401	Q-loop/lid; other site
595495010402	ABC transporter signature motif; other site
595495010403	Walker B; other site
595495010404	D-loop; other site
595495010405	H-loop/switch region; other site
595495010406	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
595495010407	dimerization interface [polypeptide binding]; other site
595495010408	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
595495010409	putative DNA binding site [nucleotide binding]; other site
595495010410	putative Zn2+ binding site [ion binding]; other site
595495010411	AsnC family; Region: AsnC_trans_reg; pfam01037
595495010412	thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126
595495010413	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495010414	active site
595495010415	motif I; other site
595495010416	motif II; other site
595495010417	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
595495010418	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
595495010419	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
595495010420	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
595495010421	Ligand Binding Site [chemical binding]; other site
595495010422	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
595495010423	active site
595495010424	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
595495010425	periplasmic folding chaperone; Provisional; Region: PRK10788
595495010426	SurA N-terminal domain; Region: SurA_N_3; cl07813
595495010427	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
595495010428	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
595495010429	IHF dimer interface [polypeptide binding]; other site
595495010430	IHF - DNA interface [nucleotide binding]; other site
595495010431	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
595495010432	Found in ATP-dependent protease La (LON); Region: LON; smart00464
595495010433	Found in ATP-dependent protease La (LON); Region: LON; smart00464
595495010434	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495010435	Walker A motif; other site
595495010436	ATP binding site [chemical binding]; other site
595495010437	Walker B motif; other site
595495010438	arginine finger; other site
595495010439	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
595495010440	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
595495010441	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
595495010442	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495010443	Walker A motif; other site
595495010444	ATP binding site [chemical binding]; other site
595495010445	Walker B motif; other site
595495010446	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
595495010447	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
595495010448	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
595495010449	oligomer interface [polypeptide binding]; other site
595495010450	active site residues [active]
595495010451	trigger factor; Provisional; Region: tig; PRK01490
595495010452	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
595495010453	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
595495010454	transcriptional regulator BolA; Provisional; Region: PRK11628
595495010455	hypothetical protein; Provisional; Region: PRK11627
595495010456	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
595495010457	muropeptide transporter; Reviewed; Region: ampG; PRK11902
595495010458	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495010459	putative substrate translocation pore; other site
595495010460	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
595495010461	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
595495010462	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
595495010463	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
595495010464	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
595495010465	D-pathway; other site
595495010466	Putative ubiquinol binding site [chemical binding]; other site
595495010467	Low-spin heme (heme b) binding site [chemical binding]; other site
595495010468	Putative water exit pathway; other site
595495010469	Binuclear center (heme o3/CuB) [ion binding]; other site
595495010470	K-pathway; other site
595495010471	Putative proton exit pathway; other site
595495010472	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
595495010473	Subunit I/III interface [polypeptide binding]; other site
595495010474	Subunit III/IV interface [polypeptide binding]; other site
595495010475	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
595495010476	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
595495010477	UbiA prenyltransferase family; Region: UbiA; pfam01040
595495010478	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
595495010479	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
595495010480	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495010481	Major Facilitator Superfamily; Region: MFS_1; pfam07690
595495010482	putative substrate translocation pore; other site
595495010483	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
595495010484	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
595495010485	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
595495010486	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
595495010487	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
595495010488	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
595495010489	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
595495010490	conserved cys residue [active]
595495010491	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
595495010492	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
595495010493	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
595495010494	Ligand Binding Site [chemical binding]; other site
595495010495	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
595495010496	active site residue [active]
595495010497	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
595495010498	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
595495010499	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
595495010500	substrate binding pocket [chemical binding]; other site
595495010501	chain length determination region; other site
595495010502	substrate-Mg2+ binding site; other site
595495010503	catalytic residues [active]
595495010504	aspartate-rich region 1; other site
595495010505	active site lid residues [active]
595495010506	aspartate-rich region 2; other site
595495010507	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
595495010508	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
595495010509	TPP-binding site; other site
595495010510	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
595495010511	PYR/PP interface [polypeptide binding]; other site
595495010512	dimer interface [polypeptide binding]; other site
595495010513	TPP binding site [chemical binding]; other site
595495010514	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
595495010515	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
595495010516	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
595495010517	active site
595495010518	catalytic tetrad [active]
595495010519	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
595495010520	tetramer interfaces [polypeptide binding]; other site
595495010521	binuclear metal-binding site [ion binding]; other site
595495010522	thiamine monophosphate kinase; Provisional; Region: PRK05731
595495010523	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
595495010524	ATP binding site [chemical binding]; other site
595495010525	dimerization interface [polypeptide binding]; other site
595495010526	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
595495010527	putative RNA binding site [nucleotide binding]; other site
595495010528	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
595495010529	homopentamer interface [polypeptide binding]; other site
595495010530	active site
595495010531	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
595495010532	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
595495010533	catalytic motif [active]
595495010534	Zn binding site [ion binding]; other site
595495010535	riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227
595495010536	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
595495010537	ATP cone domain; Region: ATP-cone; pfam03477
595495010538	hypothetical protein; Provisional; Region: PRK11530
595495010539	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
595495010540	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
595495010541	active site
595495010542	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
595495010543	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
595495010544	Protein export membrane protein; Region: SecD_SecF; pfam02355
595495010545	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
595495010546	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
595495010547	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
595495010548	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
595495010549	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
595495010550	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
595495010551	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
595495010552	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
595495010553	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
595495010554	acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045
595495010555	maltodextrin glucosidase; Provisional; Region: PRK10785
595495010556	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
595495010557	homodimer interface [polypeptide binding]; other site
595495010558	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
595495010559	active site
595495010560	homodimer interface [polypeptide binding]; other site
595495010561	catalytic site [active]
595495010562	putative proline-specific permease; Provisional; Region: proY; PRK10580
595495010563	Spore germination protein; Region: Spore_permease; cl17796
595495010564	branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433
595495010565	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
595495010566	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
595495010567	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
595495010568	putative active site [active]
595495010569	heme pocket [chemical binding]; other site
595495010570	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
595495010571	dimer interface [polypeptide binding]; other site
595495010572	phosphorylation site [posttranslational modification]
595495010573	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495010574	ATP binding site [chemical binding]; other site
595495010575	Mg2+ binding site [ion binding]; other site
595495010576	G-X-G motif; other site
595495010577	transcriptional regulator PhoB; Provisional; Region: PRK10161
595495010578	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495010579	active site
595495010580	phosphorylation site [posttranslational modification]
595495010581	intermolecular recognition site; other site
595495010582	dimerization interface [polypeptide binding]; other site
595495010583	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
595495010584	DNA binding site [nucleotide binding]
595495010585	exonuclease subunit SbcD; Provisional; Region: PRK10966
595495010586	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
595495010587	active site
595495010588	metal binding site [ion binding]; metal-binding site
595495010589	DNA binding site [nucleotide binding]
595495010590	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
595495010591	exonuclease subunit SbcC; Provisional; Region: PRK10246
595495010592	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495010593	Walker A/P-loop; other site
595495010594	ATP binding site [chemical binding]; other site
595495010595	Q-loop/lid; other site
595495010596	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495010597	ABC transporter signature motif; other site
595495010598	Walker B; other site
595495010599	D-loop; other site
595495010600	H-loop/switch region; other site
595495010601	MFS transport protein AraJ; Provisional; Region: PRK10091
595495010602	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495010603	putative substrate translocation pore; other site
595495010604	fructokinase; Reviewed; Region: PRK09557
595495010605	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
595495010606	nucleotide binding site [chemical binding]; other site
595495010607	DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974
595495010608	Protein of unknown function (DUF2773); Region: DUF2773; pfam10971
595495010609	hypothetical protein; Provisional; Region: PRK10579
595495010610	hypothetical protein; Provisional; Region: PRK10481
595495010611	hypothetical protein; Provisional; Region: PRK10380
595495010612	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
595495010613	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
595495010614	ADP binding site [chemical binding]; other site
595495010615	magnesium binding site [ion binding]; other site
595495010616	putative shikimate binding site; other site
595495010617	hypothetical protein; Validated; Region: PRK00124
595495010618	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
595495010619	pyrroline-5-carboxylate reductase; Region: PLN02688
595495010620	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
595495010621	MASE2 domain; Region: MASE2; pfam05230
595495010622	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
595495010623	metal binding site [ion binding]; metal-binding site
595495010624	active site
595495010625	I-site; other site
595495010626	hypothetical protein; Provisional; Region: PRK11505
595495010627	psiF repeat; Region: PsiF_repeat; pfam07769
595495010628	psiF repeat; Region: PsiF_repeat; pfam07769
595495010629	alkaline phosphatase; Provisional; Region: PRK10518
595495010630	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
595495010631	dimer interface [polypeptide binding]; other site
595495010632	active site
595495010633	anti-RssB factor; Provisional; Region: PRK10244
595495010634	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
595495010635	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
595495010636	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
595495010637	Protein of unknown function (DUF2754); Region: DUF2754; pfam10953
595495010638	Protein of unknown function (DUF2755); Region: DUF2755; pfam10954
595495010639	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
595495010640	microcin B17 transporter; Reviewed; Region: PRK11098
595495010641	beta-lactam binding protein AmpH; Provisional; Region: PRK10662
595495010642	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
595495010643	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
595495010644	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
595495010645	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253
595495010646	Autotransporter beta-domain; Region: Autotransporter; pfam03797
595495010647	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
595495010648	dimer interface [polypeptide binding]; other site
595495010649	active site
595495010650	Schiff base residues; other site
595495010651	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
595495010652	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
595495010653	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
595495010654	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495010655	dimer interface [polypeptide binding]; other site
595495010656	conserved gate region; other site
595495010657	putative PBP binding loops; other site
595495010658	ABC-ATPase subunit interface; other site
595495010659	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
595495010660	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
595495010661	Walker A/P-loop; other site
595495010662	ATP binding site [chemical binding]; other site
595495010663	Q-loop/lid; other site
595495010664	ABC transporter signature motif; other site
595495010665	Walker B; other site
595495010666	D-loop; other site
595495010667	H-loop/switch region; other site
595495010668	ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521
595495010669	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
595495010670	substrate binding pocket [chemical binding]; other site
595495010671	membrane-bound complex binding site; other site
595495010672	hinge residues; other site
595495010673	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
595495010674	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
595495010675	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
595495010676	DXD motif; other site
595495010677	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
595495010678	putative trimer interface [polypeptide binding]; other site
595495010679	putative CoA binding site [chemical binding]; other site
595495010680	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
595495010681	putative metal binding site [ion binding]; other site
595495010682	putative homodimer interface [polypeptide binding]; other site
595495010683	putative homotetramer interface [polypeptide binding]; other site
595495010684	putative homodimer-homodimer interface [polypeptide binding]; other site
595495010685	putative allosteric switch controlling residues; other site
595495010686	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
595495010687	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
595495010688	substrate binding site [chemical binding]; other site
595495010689	catalytic Zn binding site [ion binding]; other site
595495010690	NAD binding site [chemical binding]; other site
595495010691	structural Zn binding site [ion binding]; other site
595495010692	dimer interface [polypeptide binding]; other site
595495010693	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
595495010694	S-formylglutathione hydrolase; Region: PLN02442
595495010695	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122
595495010696	putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551
595495010697	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495010698	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495010699	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
595495010700	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
595495010701	active site
595495010702	catalytic residues [active]
595495010703	metal binding site [ion binding]; metal-binding site
595495010704	DmpG-like communication domain; Region: DmpG_comm; pfam07836
595495010705	acetaldehyde dehydrogenase; Validated; Region: PRK08300
595495010706	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
595495010707	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
595495010708	2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342
595495010709	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
595495010710	Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365
595495010711	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
595495010712	putative active site [active]
595495010713	Fe(II) binding site [ion binding]; other site
595495010714	putative dimer interface [polypeptide binding]; other site
595495010715	putative tetramer interface [polypeptide binding]; other site
595495010716	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
595495010717	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
595495010718	DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834
595495010719	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
595495010720	Bacterial transcriptional regulator; Region: IclR; pfam01614
595495010721	lac repressor; Reviewed; Region: lacI; PRK09526
595495010722	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
595495010723	DNA binding site [nucleotide binding]
595495010724	domain linker motif; other site
595495010725	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
595495010726	ligand binding site [chemical binding]; other site
595495010727	dimerization interface (open form) [polypeptide binding]; other site
595495010728	dimerization interface (closed form) [polypeptide binding]; other site
595495010729	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
595495010730	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
595495010731	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
595495010732	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
595495010733	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
595495010734	LacY proton/sugar symporter; Region: LacY_symp; pfam01306
595495010735	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495010736	putative substrate translocation pore; other site
595495010737	galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527
595495010738	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
595495010739	active site
595495010740	substrate binding site [chemical binding]; other site
595495010741	trimer interface [polypeptide binding]; other site
595495010742	CoA binding site [chemical binding]; other site
595495010743	putative cyanate transporter; Provisional; Region: cynX; PRK09705
595495010744	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495010745	Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513
595495010746	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
595495010747	oligomer interface [polypeptide binding]; other site
595495010748	active site
595495010749	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
595495010750	active site clefts [active]
595495010751	zinc binding site [ion binding]; other site
595495010752	dimer interface [polypeptide binding]; other site
595495010753	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
595495010754	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495010755	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425
595495010756	dimerization interface [polypeptide binding]; other site
595495010757	cytosine deaminase; Provisional; Region: PRK09230
595495010758	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
595495010759	active site
595495010760	nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484
595495010761	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
595495010762	Na binding site [ion binding]; other site
595495010763	putative substrate binding site [chemical binding]; other site
595495010764	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
595495010765	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
595495010766	acyl-activating enzyme (AAE) consensus motif; other site
595495010767	putative AMP binding site [chemical binding]; other site
595495010768	putative active site [active]
595495010769	putative CoA binding site [chemical binding]; other site
595495010770	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
595495010771	2-methylcitrate dehydratase; Region: prpD; TIGR02330
595495010772	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
595495010773	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
595495010774	dimer interface [polypeptide binding]; other site
595495010775	active site
595495010776	citrylCoA binding site [chemical binding]; other site
595495010777	oxalacetate/citrate binding site [chemical binding]; other site
595495010778	coenzyme A binding site [chemical binding]; other site
595495010779	catalytic triad [active]
595495010780	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
595495010781	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
595495010782	tetramer interface [polypeptide binding]; other site
595495010783	active site
595495010784	Mg2+/Mn2+ binding site [ion binding]; other site
595495010785	propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424
595495010786	Propionate catabolism activator; Region: PrpR_N; pfam06506
595495010787	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495010788	Walker A motif; other site
595495010789	ATP binding site [chemical binding]; other site
595495010790	Walker B motif; other site
595495010791	arginine finger; other site
595495010792	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
595495010793	hypothetical protein; Provisional; Region: PRK09929
595495010794	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
595495010795	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
595495010796	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
595495010797	putative NAD(P) binding site [chemical binding]; other site
595495010798	putative substrate binding site [chemical binding]; other site
595495010799	catalytic Zn binding site [ion binding]; other site
595495010800	structural Zn binding site [ion binding]; other site
595495010801	dimer interface [polypeptide binding]; other site
595495010802	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
595495010803	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
595495010804	TM-ABC transporter signature motif; other site
595495010805	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
595495010806	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
595495010807	TM-ABC transporter signature motif; other site
595495010808	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
595495010809	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
595495010810	Walker A/P-loop; other site
595495010811	ATP binding site [chemical binding]; other site
595495010812	Q-loop/lid; other site
595495010813	ABC transporter signature motif; other site
595495010814	Walker B; other site
595495010815	D-loop; other site
595495010816	H-loop/switch region; other site
595495010817	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
595495010818	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
595495010819	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
595495010820	ligand binding site [chemical binding]; other site
595495010821	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
595495010822	putative deaminase; Validated; Region: PRK06846
595495010823	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
595495010824	active site
595495010825	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
595495010826	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
595495010827	putative substrate binding site [chemical binding]; other site
595495010828	nucleotide binding site [chemical binding]; other site
595495010829	nucleotide binding site [chemical binding]; other site
595495010830	homodimer interface [polypeptide binding]; other site
595495010831	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
595495010832	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
595495010833	CoA binding domain; Region: CoA_binding; pfam02629
595495010834	CoA-ligase; Region: Ligase_CoA; pfam00549
595495010835	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
595495010836	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
595495010837	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
595495010838	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
595495010839	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
595495010840	DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094
595495010841	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495010842	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
595495010843	dimerization interface [polypeptide binding]; other site
595495010844	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
595495010845	DNA binding residues [nucleotide binding]
595495010846	dimerization interface [polypeptide binding]; other site
595495010847	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
595495010848	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
595495010849	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
595495010850	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
595495010851	Autotransporter beta-domain; Region: Autotransporter; pfam03797
595495010852	choline transport protein BetT; Provisional; Region: PRK09928
595495010853	transcriptional regulator BetI; Validated; Region: PRK00767
595495010854	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
595495010855	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
595495010856	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
595495010857	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
595495010858	tetrameric interface [polypeptide binding]; other site
595495010859	NAD binding site [chemical binding]; other site
595495010860	catalytic residues [active]
595495010861	choline dehydrogenase; Validated; Region: PRK02106
595495010862	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
595495010863	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
595495010864	Uncharacterized conserved protein [Function unknown]; Region: COG1556
595495010865	iron-sulfur cluster-binding protein; Region: TIGR00273
595495010866	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
595495010867	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
595495010868	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
595495010869	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
595495010870	Cysteine-rich domain; Region: CCG; pfam02754
595495010871	Cysteine-rich domain; Region: CCG; pfam02754
595495010872	Cupin; Region: Cupin_6; pfam12852
595495010873	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
595495010874	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495010875	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010
595495010876	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
595495010877	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
595495010878	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
595495010879	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
595495010880	Predicted membrane protein [Function unknown]; Region: COG3059
595495010881	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
595495010882	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
595495010883	active site
595495010884	catalytic tetrad [active]
595495010885	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
595495010886	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495010887	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
595495010888	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
595495010889	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
595495010890	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
595495010891	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
595495010892	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
595495010893	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
595495010894	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
595495010895	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
595495010896	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
595495010897	DNA binding residues [nucleotide binding]
595495010898	putative fimbrial protein TcfA; Provisional; Region: PRK15308
595495010899	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
595495010900	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
595495010901	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
595495010902	aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433
595495010903	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
595495010904	catalytic loop [active]
595495010905	iron binding site [ion binding]; other site
595495010906	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
595495010907	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
595495010908	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
595495010909	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
595495010910	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
595495010911	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
595495010912	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
595495010913	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
595495010914	XdhC Rossmann domain; Region: XdhC_C; pfam13478
595495010915	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
595495010916	Transcriptional regulator [Transcription]; Region: LysR; COG0583
595495010917	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
595495010918	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
595495010919	putative catalytic cysteine [active]
595495010920	gamma-glutamyl kinase; Provisional; Region: PRK05429
595495010921	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
595495010922	nucleotide binding site [chemical binding]; other site
595495010923	homotetrameric interface [polypeptide binding]; other site
595495010924	putative phosphate binding site [ion binding]; other site
595495010925	putative allosteric binding site; other site
595495010926	PUA domain; Region: PUA; pfam01472
595495010927	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
595495010928	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
595495010929	trimer interface [polypeptide binding]; other site
595495010930	eyelet of channel; other site
595495010931	DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984
595495010932	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
595495010933	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
595495010934	active site
595495010935	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
595495010936	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
595495010937	metal binding site [ion binding]; metal-binding site
595495010938	dimer interface [polypeptide binding]; other site
595495010939	peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179
595495010940	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
595495010941	hypothetical protein; Reviewed; Region: PRK09588
595495010942	release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073
595495010943	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
595495010944	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
595495010945	Coenzyme A binding pocket [chemical binding]; other site
595495010946	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
595495010947	active site
595495010948	DNA polymerase IV; Validated; Region: PRK02406
595495010949	DNA binding site [nucleotide binding]
595495010950	hypothetical protein; Validated; Region: PRK06778
595495010951	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
595495010952	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
595495010953	ligand binding site [chemical binding]; other site
595495010954	flagellar motor protein MotA; Provisional; Region: PRK12482
595495010955	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
595495010956	flagellar biosynthesis sigma factor; Provisional; Region: PRK12427
595495010957	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
595495010958	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
595495010959	DNA binding residues [nucleotide binding]
595495010960	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
595495010961	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
595495010962	adenylate kinase; Region: PLN02674
595495010963	Flagellar protein FliS; Region: FliS; cl00654
595495010964	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
595495010965	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
595495010966	flagellin; Reviewed; Region: PRK08869
595495010967	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
595495010968	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
595495010969	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
595495010970	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
595495010971	DNA binding site [nucleotide binding]
595495010972	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192
595495010973	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
595495010974	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191
595495010975	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
595495010976	Rod binding protein; Region: Rod-binding; cl01626
595495010977	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
595495010978	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
595495010979	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407
595495010980	Flagellar L-ring protein; Region: FlgH; pfam02107
595495010981	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
595495010982	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
595495010983	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
595495010984	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
595495010985	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
595495010986	flagellar hook protein FlgE; Validated; Region: flgE; PRK06803
595495010987	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
595495010988	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
595495010989	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
595495010990	Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843
595495010991	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
595495010992	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
595495010993	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802
595495010994	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
595495010995	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
595495010996	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685
595495010997	SAF-like; Region: SAF_2; pfam13144
595495010998	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
595495010999	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
595495011000	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
595495011001	FlgN protein; Region: FlgN; pfam05130
595495011002	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
595495011003	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
595495011004	active site
595495011005	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
595495011006	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
595495011007	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
595495011008	Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423
595495011009	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
595495011010	Mu DNA binding, I gamma subdomain; Region: HTH_Tnp_Mu_2; pfam09039
595495011011	Bacteriophage Mu transposase; Region: DDE_2; pfam02914
595495011012	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
595495011013	Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842
595495011014	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
595495011015	Walker A motif; other site
595495011016	ATP binding site [chemical binding]; other site
595495011017	Walker B motif; other site
595495011018	Mu B transposition protein, C terminal; Region: Phage-MuB_C; pfam09077
595495011019	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
595495011020	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
595495011021	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
595495011022	Mor transcription activator family; Region: Mor; pfam08765
595495011023	Mor transcription activator family; Region: Mor; pfam08765
595495011024	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
595495011025	catalytic residues [active]
595495011026	Protein of unknown function (DUF2730); Region: DUF2730; pfam10805
595495011027	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
595495011028	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
595495011029	Protein of unknown function (DUF935); Region: DUF935; pfam06074
595495011030	Mu-like prophage protein gp29 [Function unknown]; Region: COG4383
595495011031	Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369
595495011032	Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233
595495011033	phage virion morphogenesis (putative tail completion) protein; Region: tail_comp_S; TIGR01635
595495011034	Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123
595495011035	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; pfam10124
595495011036	Protein of unknown function (DUF1320); Region: DUF1320; pfam07030
595495011037	Domain of unknown function (DUF1834); Region: DUF1834; pfam08873
595495011038	Protein of unknown function (DUF2635); Region: DUF2635; pfam10948
595495011039	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
595495011040	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
595495011041	Phage tail tube protein; Region: Tail_tube; pfam10618
595495011042	Mu-like prophage FluMu protein gp41 [Function unknown]; Region: COG4518
595495011043	Mu-like prophage protein [General function prediction only]; Region: COG3941
595495011044	tape measure domain; Region: tape_meas_nterm; TIGR02675
595495011045	Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228
595495011046	DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157
595495011047	Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379
595495011048	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
595495011049	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
595495011050	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890
595495011051	Phage protein GP46; Region: GP46; pfam07409
595495011052	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
595495011053	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542
595495011054	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
595495011055	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
595495011056	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
595495011057	multiple promoter invertase; Provisional; Region: mpi; PRK13413
595495011058	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
595495011059	catalytic residues [active]
595495011060	catalytic nucleophile [active]
595495011061	Presynaptic Site I dimer interface [polypeptide binding]; other site
595495011062	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
595495011063	Synaptic Flat tetramer interface [polypeptide binding]; other site
595495011064	Synaptic Site I dimer interface [polypeptide binding]; other site
595495011065	DNA binding site [nucleotide binding]
595495011066	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
595495011067	DNA-binding interface [nucleotide binding]; DNA binding site
595495011068	Mu-like prophage protein Com; Region: Mu-like_Com; cl11540
595495011069	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
595495011070	active site
595495011071	nucleotide binding site [chemical binding]; other site
595495011072	HIGH motif; other site
595495011073	KMSKS motif; other site
595495011074	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
595495011075	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07196
595495011076	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
595495011077	Walker A motif/ATP binding site; other site
595495011078	Walker B motif; other site
595495011079	flagellar assembly protein H; Provisional; Region: fliH; PRK13386
595495011080	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
595495011081	Flagellar assembly protein FliH; Region: FliH; pfam02108
595495011082	flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194
595495011083	MgtE intracellular N domain; Region: MgtE_N; smart00924
595495011084	FliG C-terminal domain; Region: FliG_C; pfam01706
595495011085	flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193
595495011086	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
595495011087	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
595495011088	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
595495011089	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
595495011090	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495011091	Walker A motif; other site
595495011092	ATP binding site [chemical binding]; other site
595495011093	Walker B motif; other site
595495011094	arginine finger; other site
595495011095	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
595495011096	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
595495011097	flagellar motor switch protein FliN; Region: fliN; TIGR02480
595495011098	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
595495011099	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
595495011100	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
595495011101	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
595495011102	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
595495011103	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298
595495011104	FHIPEP family; Region: FHIPEP; pfam00771
595495011105	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
595495011106	HicB family; Region: HicB; pfam05534
595495011107	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
595495011108	NlpC/P60 family; Region: NLPC_P60; pfam00877
595495011109	RelB antitoxin; Region: RelB; cl01171
595495011110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
595495011111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
595495011112	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
595495011113	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
595495011114	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
595495011115	putative active site [active]
595495011116	putative dimer interface [polypeptide binding]; other site
595495011117	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
595495011118	dimer interface [polypeptide binding]; other site
595495011119	active site
595495011120	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
595495011121	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
595495011122	active site
595495011123	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
595495011124	C-lysozyme inhibitor; Provisional; Region: PRK09993
595495011125	C-N hydrolase family amidase; Provisional; Region: PRK10438
595495011126	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
595495011127	putative active site [active]
595495011128	catalytic triad [active]
595495011129	dimer interface [polypeptide binding]; other site
595495011130	multimer interface [polypeptide binding]; other site
595495011131	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
595495011132	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
595495011133	Transposase [DNA replication, recombination, and repair]; Region: COG5433
595495011134	Transposase [DNA replication, recombination, and repair]; Region: COG5433
595495011135	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
595495011136	RHS Repeat; Region: RHS_repeat; pfam05593
595495011137	RHS Repeat; Region: RHS_repeat; pfam05593
595495011138	RHS Repeat; Region: RHS_repeat; pfam05593
595495011139	RHS Repeat; Region: RHS_repeat; pfam05593
595495011140	RHS Repeat; Region: RHS_repeat; cl11982
595495011141	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
595495011142	RHS Repeat; Region: RHS_repeat; pfam05593
595495011143	RHS Repeat; Region: RHS_repeat; pfam05593
595495011144	RHS protein; Region: RHS; pfam03527
595495011145	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
595495011146	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
595495011147	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
595495011148	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
595495011149	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
595495011150	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
595495011151	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3516
595495011152	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
595495011153	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
595495011154	Protein of unknown function (DUF877); Region: DUF877; pfam05943
595495011155	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
595495011156	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
595495011157	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
595495011158	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3520
595495011159	Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular    transport; Signal transduction mechanisms]; Region: COG3456
595495011160	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3521
595495011161	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
595495011162	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
595495011163	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
595495011164	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
595495011165	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495011166	Walker A motif; other site
595495011167	ATP binding site [chemical binding]; other site
595495011168	Walker B motif; other site
595495011169	arginine finger; other site
595495011170	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495011171	Walker A motif; other site
595495011172	ATP binding site [chemical binding]; other site
595495011173	Walker B motif; other site
595495011174	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
595495011175	type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360
595495011176	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
595495011177	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
595495011178	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
595495011179	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
595495011180	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
595495011181	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
595495011182	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
595495011183	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
595495011184	ImpA domain protein; Region: DUF3702; pfam12486
595495011185	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
595495011186	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
595495011187	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
595495011188	active site
595495011189	catalytic site [active]
595495011190	substrate binding site [chemical binding]; other site
595495011191	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
595495011192	RNA/DNA hybrid binding site [nucleotide binding]; other site
595495011193	active site
595495011194	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495011195	hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241
595495011196	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
595495011197	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
595495011198	N-acetyl-D-glucosamine binding site [chemical binding]; other site
595495011199	catalytic residue [active]
595495011200	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
595495011201	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
595495011202	Methyltransferase domain; Region: Methyltransf_31; pfam13847
595495011203	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495011204	S-adenosylmethionine binding site [chemical binding]; other site
595495011205	hypothetical protein; Provisional; Region: PRK05421
595495011206	putative catalytic site [active]
595495011207	putative metal binding site [ion binding]; other site
595495011208	putative phosphate binding site [ion binding]; other site
595495011209	putative catalytic site [active]
595495011210	putative phosphate binding site [ion binding]; other site
595495011211	putative metal binding site [ion binding]; other site
595495011212	Transcriptional regulator [Transcription]; Region: LysR; COG0583
595495011213	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495011214	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
595495011215	putative effector binding pocket; other site
595495011216	dimerization interface [polypeptide binding]; other site
595495011217	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
595495011218	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
595495011219	active site
595495011220	catalytic tetrad [active]
595495011221	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
595495011222	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495011223	active site
595495011224	motif I; other site
595495011225	motif II; other site
595495011226	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
595495011227	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
595495011228	Walker A/P-loop; other site
595495011229	ATP binding site [chemical binding]; other site
595495011230	Q-loop/lid; other site
595495011231	ABC transporter signature motif; other site
595495011232	Walker B; other site
595495011233	D-loop; other site
595495011234	H-loop/switch region; other site
595495011235	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
595495011236	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495011237	dimer interface [polypeptide binding]; other site
595495011238	conserved gate region; other site
595495011239	ABC-ATPase subunit interface; other site
595495011240	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
595495011241	lipoprotein, YaeC family; Region: TIGR00363
595495011242	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
595495011243	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
595495011244	homodimer interaction site [polypeptide binding]; other site
595495011245	cofactor binding site; other site
595495011246	prolyl-tRNA synthetase; Provisional; Region: PRK09194
595495011247	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
595495011248	dimer interface [polypeptide binding]; other site
595495011249	motif 1; other site
595495011250	active site
595495011251	motif 2; other site
595495011252	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
595495011253	putative deacylase active site [active]
595495011254	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
595495011255	active site
595495011256	motif 3; other site
595495011257	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
595495011258	anticodon binding site; other site
595495011259	hypothetical protein; Provisional; Region: PRK11479
595495011260	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
595495011261	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
595495011262	NlpE N-terminal domain; Region: NlpE; pfam04170
595495011263	hypothetical protein; Provisional; Region: PRK09256
595495011264	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
595495011265	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681
595495011266	hypothetical protein; Provisional; Region: PRK04964
595495011267	Rho-binding antiterminator; Provisional; Region: PRK11625
595495011268	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
595495011269	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
595495011270	Ligand Binding Site [chemical binding]; other site
595495011271	TilS substrate binding domain; Region: TilS; pfam09179
595495011272	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
595495011273	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
595495011274	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
595495011275	putative metal binding site [ion binding]; other site
595495011276	lysine decarboxylase LdcC; Provisional; Region: PRK15399
595495011277	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
595495011278	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
595495011279	homodimer interface [polypeptide binding]; other site
595495011280	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495011281	catalytic residue [active]
595495011282	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
595495011283	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
595495011284	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
595495011285	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
595495011286	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
595495011287	putative active site [active]
595495011288	putative PHP Thumb interface [polypeptide binding]; other site
595495011289	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
595495011290	generic binding surface II; other site
595495011291	generic binding surface I; other site
595495011292	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
595495011293	RNA/DNA hybrid binding site [nucleotide binding]; other site
595495011294	active site
595495011295	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
595495011296	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
595495011297	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
595495011298	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
595495011299	active site
595495011300	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
595495011301	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
595495011302	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
595495011303	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
595495011304	trimer interface [polypeptide binding]; other site
595495011305	active site
595495011306	UDP-GlcNAc binding site [chemical binding]; other site
595495011307	lipid binding site [chemical binding]; lipid-binding site
595495011308	periplasmic chaperone; Provisional; Region: PRK10780
595495011309	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
595495011310	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
595495011311	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
595495011312	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
595495011313	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
595495011314	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
595495011315	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
595495011316	Surface antigen; Region: Bac_surface_Ag; pfam01103
595495011317	zinc metallopeptidase RseP; Provisional; Region: PRK10779
595495011318	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
595495011319	active site
595495011320	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
595495011321	protein binding site [polypeptide binding]; other site
595495011322	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
595495011323	putative substrate binding region [chemical binding]; other site
595495011324	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
595495011325	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
595495011326	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
595495011327	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
595495011328	catalytic residue [active]
595495011329	putative FPP diphosphate  binding site; other site
595495011330	putative FPP binding hydrophobic cleft; other site
595495011331	dimer interface [polypeptide binding]; other site
595495011332	putative IPP diphosphate binding site; other site
595495011333	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
595495011334	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
595495011335	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
595495011336	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
595495011337	ribosome recycling factor; Reviewed; Region: frr; PRK00083
595495011338	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
595495011339	hinge region; other site
595495011340	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
595495011341	putative nucleotide binding site [chemical binding]; other site
595495011342	uridine monophosphate binding site [chemical binding]; other site
595495011343	homohexameric interface [polypeptide binding]; other site
595495011344	elongation factor Ts; Provisional; Region: tsf; PRK09377
595495011345	UBA/TS-N domain; Region: UBA; pfam00627
595495011346	Elongation factor TS; Region: EF_TS; pfam00889
595495011347	Elongation factor TS; Region: EF_TS; pfam00889
595495011348	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
595495011349	rRNA interaction site [nucleotide binding]; other site
595495011350	S8 interaction site; other site
595495011351	putative laminin-1 binding site; other site
595495011352	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
595495011353	active site
595495011354	PII uridylyl-transferase; Provisional; Region: PRK05007
595495011355	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
595495011356	metal binding triad; other site
595495011357	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
595495011358	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
595495011359	Zn2+ binding site [ion binding]; other site
595495011360	Mg2+ binding site [ion binding]; other site
595495011361	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
595495011362	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
595495011363	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
595495011364	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
595495011365	trimer interface [polypeptide binding]; other site
595495011366	active site
595495011367	substrate binding site [chemical binding]; other site
595495011368	CoA binding site [chemical binding]; other site
595495011369	hypothetical protein; Provisional; Region: PRK13677
595495011370	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
595495011371	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
595495011372	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
595495011373	serine endoprotease; Provisional; Region: PRK10942
595495011374	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
595495011375	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
595495011376	protein binding site [polypeptide binding]; other site
595495011377	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
595495011378	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
595495011379	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
595495011380	Zn2+ binding site [ion binding]; other site
595495011381	Mg2+ binding site [ion binding]; other site
595495011382	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
595495011383	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
595495011384	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
595495011385	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
595495011386	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
595495011387	cobalamin binding residues [chemical binding]; other site
595495011388	putative BtuC binding residues; other site
595495011389	dimer interface [polypeptide binding]; other site
595495011390	hypothetical protein; Provisional; Region: PRK10578
595495011391	UPF0126 domain; Region: UPF0126; pfam03458
595495011392	UPF0126 domain; Region: UPF0126; pfam03458
595495011393	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
595495011394	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
595495011395	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
595495011396	Cl- selectivity filter; other site
595495011397	Cl- binding residues [ion binding]; other site
595495011398	pore gating glutamate residue; other site
595495011399	dimer interface [polypeptide binding]; other site
595495011400	H+/Cl- coupling transport residue; other site
595495011401	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
595495011402	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
595495011403	inhibitor-cofactor binding pocket; inhibition site
595495011404	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495011405	catalytic residue [active]
595495011406	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
595495011407	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
595495011408	ABC-ATPase subunit  interface; other site
595495011409	dimer interface [polypeptide binding]; other site
595495011410	putative PBP binding regions; other site
595495011411	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
595495011412	ABC-ATPase subunit  interface; other site
595495011413	dimer interface [polypeptide binding]; other site
595495011414	putative PBP binding regions; other site
595495011415	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
595495011416	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
595495011417	siderophore binding site; other site
595495011418	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
595495011419	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
595495011420	Walker A/P-loop; other site
595495011421	ATP binding site [chemical binding]; other site
595495011422	Q-loop/lid; other site
595495011423	ABC transporter signature motif; other site
595495011424	Walker B; other site
595495011425	D-loop; other site
595495011426	H-loop/switch region; other site
595495011427	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
595495011428	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
595495011429	N-terminal plug; other site
595495011430	ligand-binding site [chemical binding]; other site
595495011431	bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506
595495011432	Transglycosylase; Region: Transgly; pfam00912
595495011433	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
595495011434	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
595495011435	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
595495011436	ATP binding site [chemical binding]; other site
595495011437	putative Mg++ binding site [ion binding]; other site
595495011438	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
595495011439	nucleotide binding region [chemical binding]; other site
595495011440	ATP-binding site [chemical binding]; other site
595495011441	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
595495011442	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
595495011443	2'-5' RNA ligase; Provisional; Region: PRK15124
595495011444	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
595495011445	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
595495011446	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
595495011447	RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778
595495011448	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
595495011449	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
595495011450	active site
595495011451	nucleotide binding site [chemical binding]; other site
595495011452	HIGH motif; other site
595495011453	KMSKS motif; other site
595495011454	poly(A) polymerase I; Provisional; Region: pcnB; PRK11623
595495011455	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
595495011456	active site
595495011457	NTP binding site [chemical binding]; other site
595495011458	metal binding triad [ion binding]; metal-binding site
595495011459	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
595495011460	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
595495011461	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
595495011462	catalytic center binding site [active]
595495011463	ATP binding site [chemical binding]; other site
595495011464	Fimbrial protein; Region: Fimbrial; cl01416
595495011465	putative chaperone protein EcpD; Provisional; Region: PRK09926
595495011466	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
595495011467	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
595495011468	putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828
595495011469	PapC N-terminal domain; Region: PapC_N; pfam13954
595495011470	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
595495011471	PapC C-terminal domain; Region: PapC_C; pfam13953
595495011472	Fimbrial protein; Region: Fimbrial; cl01416
595495011473	putative fimbrial protein StaE; Provisional; Region: PRK15263
595495011474	putative fimbrial protein StaF; Provisional; Region: PRK15262
595495011475	putative fimbrial-like adhesin protein; Provisional; Region: PRK09723
595495011476	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
595495011477	oligomerization interface [polypeptide binding]; other site
595495011478	active site
595495011479	metal binding site [ion binding]; metal-binding site
595495011480	pantoate--beta-alanine ligase; Region: panC; TIGR00018
595495011481	Pantoate-beta-alanine ligase; Region: PanC; cd00560
595495011482	active site
595495011483	ATP-binding site [chemical binding]; other site
595495011484	pantoate-binding site; other site
595495011485	HXXH motif; other site
595495011486	Uncharacterized conserved protein [Function unknown]; Region: COG5464
595495011487	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
595495011488	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
595495011489	tetramerization interface [polypeptide binding]; other site
595495011490	active site
595495011491	Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966
595495011492	putative active site [active]
595495011493	putative metal binding site [ion binding]; other site
595495011494	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
595495011495	active pocket/dimerization site; other site
595495011496	active site
595495011497	phosphorylation site [posttranslational modification]
595495011498	inner membrane transport permease; Provisional; Region: PRK15066
595495011499	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
595495011500	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
595495011501	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
595495011502	Walker A/P-loop; other site
595495011503	ATP binding site [chemical binding]; other site
595495011504	Q-loop/lid; other site
595495011505	ABC transporter signature motif; other site
595495011506	Walker B; other site
595495011507	D-loop; other site
595495011508	H-loop/switch region; other site
595495011509	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
595495011510	active site clefts [active]
595495011511	zinc binding site [ion binding]; other site
595495011512	dimer interface [polypeptide binding]; other site
595495011513	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
595495011514	active site
595495011515	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
595495011516	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
595495011517	Trp docking motif [polypeptide binding]; other site
595495011518	putative active site [active]
595495011519	multicopper oxidase; Provisional; Region: PRK10965
595495011520	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
595495011521	Multicopper oxidase; Region: Cu-oxidase; pfam00394
595495011522	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
595495011523	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
595495011524	spermidine synthase; Provisional; Region: PRK00811
595495011525	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495011526	S-adenosylmethionine binding site [chemical binding]; other site
595495011527	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
595495011528	hypothetical protein; Provisional; Region: PRK05248
595495011529	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
595495011530	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
595495011531	substrate binding site [chemical binding]; other site
595495011532	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
595495011533	substrate binding site [chemical binding]; other site
595495011534	ligand binding site [chemical binding]; other site
595495011535	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
595495011536	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
595495011537	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
595495011538	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
595495011539	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
595495011540	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
595495011541	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
595495011542	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
595495011543	E3 interaction surface; other site
595495011544	lipoyl attachment site [posttranslational modification]; other site
595495011545	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
595495011546	E3 interaction surface; other site
595495011547	lipoyl attachment site [posttranslational modification]; other site
595495011548	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
595495011549	E3 interaction surface; other site
595495011550	lipoyl attachment site [posttranslational modification]; other site
595495011551	e3 binding domain; Region: E3_binding; pfam02817
595495011552	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
595495011553	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
595495011554	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
595495011555	dimer interface [polypeptide binding]; other site
595495011556	TPP-binding site [chemical binding]; other site
595495011557	Transcriptional regulators [Transcription]; Region: FadR; COG2186
595495011558	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495011559	DNA-binding site [nucleotide binding]; DNA binding site
595495011560	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
595495011561	aromatic amino acid transporter; Provisional; Region: PRK10238
595495011562	regulatory protein AmpE; Provisional; Region: PRK10987
595495011563	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
595495011564	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
595495011565	amidase catalytic site [active]
595495011566	Zn binding residues [ion binding]; other site
595495011567	substrate binding site [chemical binding]; other site
595495011568	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
595495011569	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
595495011570	dimerization interface [polypeptide binding]; other site
595495011571	active site
595495011572	putative major pilin subunit; Provisional; Region: PRK10574
595495011573	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
595495011574	Pilin (bacterial filament); Region: Pilin; pfam00114
595495011575	hypothetical protein; Provisional; Region: PRK10436
595495011576	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
595495011577	Walker A motif; other site
595495011578	ATP binding site [chemical binding]; other site
595495011579	Walker B motif; other site
595495011580	type IV pilin biogenesis protein; Provisional; Region: PRK10573
595495011581	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
595495011582	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
595495011583	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
595495011584	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
595495011585	active site
595495011586	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
595495011587	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
595495011588	CoA-binding site [chemical binding]; other site
595495011589	ATP-binding [chemical binding]; other site
595495011590	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582
595495011591	DNA gyrase inhibitor; Reviewed; Region: PRK00418
595495011592	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
595495011593	active site
595495011594	8-oxo-dGMP binding site [chemical binding]; other site
595495011595	nudix motif; other site
595495011596	metal binding site [ion binding]; metal-binding site
595495011597	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
595495011598	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
595495011599	SEC-C motif; Region: SEC-C; pfam02810
595495011600	SecA regulator SecM; Provisional; Region: PRK02943
595495011601	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
595495011602	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
595495011603	cell division protein FtsZ; Validated; Region: PRK09330
595495011604	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
595495011605	nucleotide binding site [chemical binding]; other site
595495011606	SulA interaction site; other site
595495011607	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
595495011608	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
595495011609	Cell division protein FtsA; Region: FtsA; pfam14450
595495011610	cell division protein FtsQ; Provisional; Region: PRK10775
595495011611	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
595495011612	Cell division protein FtsQ; Region: FtsQ; pfam03799
595495011613	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
595495011614	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
595495011615	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
595495011616	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
595495011617	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
595495011618	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
595495011619	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
595495011620	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
595495011621	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
595495011622	active site
595495011623	homodimer interface [polypeptide binding]; other site
595495011624	cell division protein FtsW; Provisional; Region: PRK10774
595495011625	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
595495011626	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
595495011627	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
595495011628	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
595495011629	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
595495011630	Mg++ binding site [ion binding]; other site
595495011631	putative catalytic motif [active]
595495011632	putative substrate binding site [chemical binding]; other site
595495011633	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
595495011634	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
595495011635	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
595495011636	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
595495011637	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
595495011638	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
595495011639	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
595495011640	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
595495011641	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
595495011642	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
595495011643	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
595495011644	cell division protein FtsL; Provisional; Region: PRK10772
595495011645	16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006
595495011646	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
595495011647	mraZ protein; Region: TIGR00242
595495011648	MraZ protein; Region: MraZ; pfam02381
595495011649	MraZ protein; Region: MraZ; pfam02381
595495011650	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
595495011651	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
595495011652	DNA binding site [nucleotide binding]
595495011653	domain linker motif; other site
595495011654	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
595495011655	dimerization interface [polypeptide binding]; other site
595495011656	ligand binding site [chemical binding]; other site
595495011657	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
595495011658	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
595495011659	putative valine binding site [chemical binding]; other site
595495011660	dimer interface [polypeptide binding]; other site
595495011661	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
595495011662	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
595495011663	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
595495011664	PYR/PP interface [polypeptide binding]; other site
595495011665	dimer interface [polypeptide binding]; other site
595495011666	TPP binding site [chemical binding]; other site
595495011667	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
595495011668	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
595495011669	TPP-binding site [chemical binding]; other site
595495011670	dimer interface [polypeptide binding]; other site
595495011671	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
595495011672	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495011673	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
595495011674	putative substrate binding pocket [chemical binding]; other site
595495011675	putative dimerization interface [polypeptide binding]; other site
595495011676	2-isopropylmalate synthase; Validated; Region: PRK00915
595495011677	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
595495011678	active site
595495011679	catalytic residues [active]
595495011680	metal binding site [ion binding]; metal-binding site
595495011681	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
595495011682	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
595495011683	tartrate dehydrogenase; Region: TTC; TIGR02089
595495011684	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
595495011685	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
595495011686	substrate binding site [chemical binding]; other site
595495011687	ligand binding site [chemical binding]; other site
595495011688	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
595495011689	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
595495011690	substrate binding site [chemical binding]; other site
595495011691	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495011692	sugar efflux transporter; Region: 2A0120; TIGR00899
595495011693	putative substrate translocation pore; other site
595495011694	transcriptional regulator SgrR; Provisional; Region: PRK13626
595495011695	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
595495011696	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
595495011697	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
595495011698	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
595495011699	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
595495011700	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495011701	dimer interface [polypeptide binding]; other site
595495011702	conserved gate region; other site
595495011703	putative PBP binding loops; other site
595495011704	ABC-ATPase subunit interface; other site
595495011705	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495011706	dimer interface [polypeptide binding]; other site
595495011707	conserved gate region; other site
595495011708	putative PBP binding loops; other site
595495011709	ABC-ATPase subunit interface; other site
595495011710	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
595495011711	ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298
595495011712	Walker A/P-loop; other site
595495011713	ATP binding site [chemical binding]; other site
595495011714	Q-loop/lid; other site
595495011715	ABC transporter signature motif; other site
595495011716	Walker B; other site
595495011717	D-loop; other site
595495011718	H-loop/switch region; other site
595495011719	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
595495011720	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
595495011721	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
595495011722	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
595495011723	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495011724	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495011725	ribulokinase; Provisional; Region: PRK04123
595495011726	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
595495011727	N- and C-terminal domain interface [polypeptide binding]; other site
595495011728	active site
595495011729	MgATP binding site [chemical binding]; other site
595495011730	catalytic site [active]
595495011731	metal binding site [ion binding]; metal-binding site
595495011732	carbohydrate binding site [chemical binding]; other site
595495011733	homodimer interface [polypeptide binding]; other site
595495011734	L-arabinose isomerase; Provisional; Region: PRK02929
595495011735	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
595495011736	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
595495011737	trimer interface [polypeptide binding]; other site
595495011738	putative substrate binding site [chemical binding]; other site
595495011739	putative metal binding site [ion binding]; other site
595495011740	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
595495011741	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
595495011742	intersubunit interface [polypeptide binding]; other site
595495011743	active site
595495011744	Zn2+ binding site [ion binding]; other site
595495011745	DNA polymerase II; Reviewed; Region: PRK05762
595495011746	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
595495011747	active site
595495011748	catalytic site [active]
595495011749	substrate binding site [chemical binding]; other site
595495011750	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
595495011751	active site
595495011752	metal-binding site
595495011753	ATP-dependent helicase HepA; Validated; Region: PRK04914
595495011754	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
595495011755	ATP binding site [chemical binding]; other site
595495011756	putative Mg++ binding site [ion binding]; other site
595495011757	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
595495011758	nucleotide binding region [chemical binding]; other site
595495011759	ATP-binding site [chemical binding]; other site
595495011760	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
595495011761	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
595495011762	active site
595495011763	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
595495011764	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
595495011765	putative metal binding site [ion binding]; other site
595495011766	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
595495011767	HSP70 interaction site [polypeptide binding]; other site
595495011768	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
595495011769	OstA-like protein; Region: OstA; pfam03968
595495011770	Organic solvent tolerance protein; Region: OstA_C; pfam04453
595495011771	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
595495011772	SurA N-terminal domain; Region: SurA_N; pfam09312
595495011773	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
595495011774	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
595495011775	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
595495011776	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
595495011777	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
595495011778	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
595495011779	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
595495011780	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
595495011781	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
595495011782	active site
595495011783	metal binding site [ion binding]; metal-binding site
595495011784	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
595495011785	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
595495011786	folate binding site [chemical binding]; other site
595495011787	NADP+ binding site [chemical binding]; other site
595495011788	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
595495011789	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
595495011790	TrkA-N domain; Region: TrkA_N; pfam02254
595495011791	glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871
595495011792	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495011793	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
595495011794	putative substrate translocation pore; other site
595495011795	ferredoxin-like protein FixX; Provisional; Region: PRK15449
595495011796	putative oxidoreductase FixC; Provisional; Region: PRK10157
595495011797	putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363
595495011798	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
595495011799	Ligand binding site [chemical binding]; other site
595495011800	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
595495011801	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
595495011802	Ligand binding site [chemical binding]; other site
595495011803	Electron transfer flavoprotein domain; Region: ETF; pfam01012
595495011804	L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356
595495011805	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
595495011806	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
595495011807	active site
595495011808	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
595495011809	CoA-transferase family III; Region: CoA_transf_3; pfam02515
595495011810	putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008
595495011811	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
595495011812	acyl-activating enzyme (AAE) consensus motif; other site
595495011813	putative AMP binding site [chemical binding]; other site
595495011814	putative active site [active]
595495011815	putative CoA binding site [chemical binding]; other site
595495011816	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
595495011817	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
595495011818	substrate binding site [chemical binding]; other site
595495011819	oxyanion hole (OAH) forming residues; other site
595495011820	trimer interface [polypeptide binding]; other site
595495011821	carnitine operon protein CaiE; Provisional; Region: PRK13627
595495011822	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
595495011823	putative trimer interface [polypeptide binding]; other site
595495011824	putative metal binding site [ion binding]; other site
595495011825	DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476
595495011826	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
595495011827	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
595495011828	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
595495011829	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
595495011830	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
595495011831	ATP-grasp domain; Region: ATP-grasp_4; cl17255
595495011832	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
595495011833	IMP binding site; other site
595495011834	dimer interface [polypeptide binding]; other site
595495011835	interdomain contacts; other site
595495011836	partial ornithine binding site; other site
595495011837	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
595495011838	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
595495011839	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
595495011840	catalytic site [active]
595495011841	subunit interface [polypeptide binding]; other site
595495011842	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
595495011843	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
595495011844	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
595495011845	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
595495011846	active site
595495011847	tetramer interface [polypeptide binding]; other site
595495011848	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
595495011849	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
595495011850	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
595495011851	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
595495011852	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
595495011853	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
595495011854	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
595495011855	HIGH motif; other site
595495011856	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
595495011857	active site
595495011858	KMSKS motif; other site
595495011859	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
595495011860	tRNA binding surface [nucleotide binding]; other site
595495011861	anticodon binding site; other site
595495011862	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
595495011863	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
595495011864	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
595495011865	active site
595495011866	Riboflavin kinase; Region: Flavokinase; smart00904
595495011867	Protein of unknown function (DUF2575); Region: DUF2575; pfam10837
595495011868	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
595495011869	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
595495011870	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495011871	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
595495011872	putative dimerization interface [polypeptide binding]; other site
595495011873	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
595495011874	Hok/gef family; Region: HOK_GEF; pfam01848
595495011875	chaperone protein DnaJ; Provisional; Region: PRK10767
595495011876	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
595495011877	HSP70 interaction site [polypeptide binding]; other site
595495011878	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
595495011879	substrate binding site [polypeptide binding]; other site
595495011880	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
595495011881	Zn binding sites [ion binding]; other site
595495011882	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
595495011883	dimer interface [polypeptide binding]; other site
595495011884	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
595495011885	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
595495011886	nucleotide binding site [chemical binding]; other site
595495011887	NEF interaction site [polypeptide binding]; other site
595495011888	SBD interface [polypeptide binding]; other site
595495011889	hypothetical protein; Provisional; Region: PRK10154
595495011890	hypothetical protein; Provisional; Region: PRK10236
595495011891	Domain of unknown function (DUF3944); Region: DUF3944; pfam13099
595495011892	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
595495011893	hypothetical protein; Provisional; Region: PRK10659
595495011894	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
595495011895	MPT binding site; other site
595495011896	trimer interface [polypeptide binding]; other site
595495011897	transaldolase-like protein; Provisional; Region: PTZ00411
595495011898	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
595495011899	active site
595495011900	dimer interface [polypeptide binding]; other site
595495011901	catalytic residue [active]
595495011902	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
595495011903	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
595495011904	hypothetical protein; Validated; Region: PRK02101
595495011905	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
595495011906	Transposase; Region: DEDD_Tnp_IS110; pfam01548
595495011907	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
595495011908	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
595495011909	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
595495011910	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
595495011911	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495011912	catalytic residue [active]
595495011913	homoserine kinase; Region: thrB; TIGR00191
595495011914	Protein of unknown function; Region: YhfT; pfam10797
595495011915	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
595495011916	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
595495011917	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
595495011918	putative catalytic residues [active]
595495011919	putative nucleotide binding site [chemical binding]; other site
595495011920	putative aspartate binding site [chemical binding]; other site
595495011921	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
595495011922	dimer interface [polypeptide binding]; other site
595495011923	putative threonine allosteric regulatory site; other site
595495011924	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
595495011925	putative threonine allosteric regulatory site; other site
595495011926	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
595495011927	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
595495011928	putative RNA methyltransferase; Provisional; Region: PRK10433
595495011929	RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050
595495011930	two-component response regulator; Provisional; Region: PRK11173
595495011931	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495011932	active site
595495011933	phosphorylation site [posttranslational modification]
595495011934	intermolecular recognition site; other site
595495011935	dimerization interface [polypeptide binding]; other site
595495011936	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
595495011937	DNA binding site [nucleotide binding]
595495011938	Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452
595495011939	sensory histidine kinase CreC; Provisional; Region: PRK11100
595495011940	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
595495011941	dimerization interface [polypeptide binding]; other site
595495011942	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
595495011943	dimer interface [polypeptide binding]; other site
595495011944	phosphorylation site [posttranslational modification]
595495011945	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495011946	ATP binding site [chemical binding]; other site
595495011947	Mg2+ binding site [ion binding]; other site
595495011948	G-X-G motif; other site
595495011949	DNA-binding response regulator CreB; Provisional; Region: PRK11083
595495011950	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495011951	active site
595495011952	phosphorylation site [posttranslational modification]
595495011953	intermolecular recognition site; other site
595495011954	dimerization interface [polypeptide binding]; other site
595495011955	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
595495011956	DNA binding site [nucleotide binding]
595495011957	hypothetical protein; Provisional; Region: PRK10756
595495011958	CreA protein; Region: CreA; pfam05981
595495011959	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
595495011960	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495011961	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
595495011962	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
595495011963	catalytic core [active]
595495011964	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
595495011965	Trp operon repressor; Provisional; Region: PRK01381
595495011966	lytic murein transglycosylase; Provisional; Region: PRK11619
595495011967	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
595495011968	N-acetyl-D-glucosamine binding site [chemical binding]; other site
595495011969	catalytic residue [active]
595495011970	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
595495011971	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495011972	Walker A/P-loop; other site
595495011973	ATP binding site [chemical binding]; other site
595495011974	Q-loop/lid; other site
595495011975	ABC transporter signature motif; other site
595495011976	Walker B; other site
595495011977	D-loop; other site
595495011978	H-loop/switch region; other site
595495011979	ABC transporter; Region: ABC_tran_2; pfam12848
595495011980	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
595495011981	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
595495011982	non-specific DNA binding site [nucleotide binding]; other site
595495011983	salt bridge; other site
595495011984	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
595495011985	sequence-specific DNA binding site [nucleotide binding]; other site
595495011986	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
595495011987	active site
595495011988	(T/H)XGH motif; other site
595495011989	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
595495011990	DNA repair protein RadA; Region: sms; TIGR00416
595495011991	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
595495011992	Walker A motif/ATP binding site; other site
595495011993	ATP binding site [chemical binding]; other site
595495011994	Walker B motif; other site
595495011995	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
595495011996	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
595495011997	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495011998	motif II; other site
595495011999	hypothetical protein; Provisional; Region: PRK11246
595495012000	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
595495012001	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
595495012002	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
595495012003	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
595495012004	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
595495012005	phosphopentomutase; Provisional; Region: PRK05362
595495012006	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
595495012007	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
595495012008	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
595495012009	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
595495012010	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
595495012011	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
595495012012	intersubunit interface [polypeptide binding]; other site
595495012013	active site
595495012014	catalytic residue [active]
595495012015	hypothetical protein; Provisional; Region: PRK10977
595495012016	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
595495012017	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
595495012018	FeS/SAM binding site; other site
595495012019	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
595495012020	active site
595495012021	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
595495012022	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
595495012023	active site
595495012024	nucleophile elbow; other site
595495012025	periplasmic protein; Provisional; Region: PRK10568
595495012026	BON domain; Region: BON; pfam04972
595495012027	BON domain; Region: BON; pfam04972
595495012028	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
595495012029	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
595495012030	G1 box; other site
595495012031	putative GEF interaction site [polypeptide binding]; other site
595495012032	GTP/Mg2+ binding site [chemical binding]; other site
595495012033	Switch I region; other site
595495012034	G2 box; other site
595495012035	G3 box; other site
595495012036	Switch II region; other site
595495012037	G4 box; other site
595495012038	G5 box; other site
595495012039	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
595495012040	dUMP phosphatase; Provisional; Region: PRK09449
595495012041	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495012042	motif II; other site
595495012043	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
595495012044	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
595495012045	Coenzyme A binding pocket [chemical binding]; other site
595495012046	DNA polymerase III, psi subunit [DNA replication, recombination, and repair]; Region: HolD; COG3050
595495012047	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
595495012048	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
595495012049	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495012050	S-adenosylmethionine binding site [chemical binding]; other site
595495012051	Protein of unknown function (DUF1435); Region: DUF1435; pfam07256
595495012052	ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647
595495012053	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
595495012054	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
595495012055	DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475
595495012056	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
595495012057	DNA binding residues [nucleotide binding]
595495012058	dimerization interface [polypeptide binding]; other site
595495012059	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
595495012060	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
595495012061	DNA binding residues [nucleotide binding]
595495012062	dimerization interface [polypeptide binding]; other site
595495012063	Uncharacterized conserved protein [Function unknown]; Region: COG2966
595495012064	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
595495012065	hypothetical protein; Provisional; Region: PRK09917
595495012066	primosomal protein DnaI; Provisional; Region: PRK02854
595495012067	DNA replication protein DnaC; Validated; Region: PRK07952
595495012068	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495012069	Walker A motif; other site
595495012070	ATP binding site [chemical binding]; other site
595495012071	Walker B motif; other site
595495012072	hypothetical protein; Provisional; Region: PRK11667
595495012073	phosphoglycerol transferase I; Provisional; Region: PRK03776
595495012074	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
595495012075	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
595495012076	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
595495012077	putative NAD(P) binding site [chemical binding]; other site
595495012078	catalytic Zn binding site [ion binding]; other site
595495012079	structural Zn binding site [ion binding]; other site
595495012080	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495012081	DNA-binding site [nucleotide binding]; DNA binding site
595495012082	Transcriptional regulators [Transcription]; Region: GntR; COG1802
595495012083	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
595495012084	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
595495012085	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495012086	D-galactonate transporter; Region: 2A0114; TIGR00893
595495012087	putative substrate translocation pore; other site
595495012088	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
595495012089	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
595495012090	dimer interface [polypeptide binding]; other site
595495012091	ligand binding site [chemical binding]; other site
595495012092	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
595495012093	dimerization interface [polypeptide binding]; other site
595495012094	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
595495012095	dimer interface [polypeptide binding]; other site
595495012096	putative CheW interface [polypeptide binding]; other site
595495012097	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
595495012098	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
595495012099	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203
595495012100	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit; Region: HpaG-N-term; TIGR02305
595495012101	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
595495012102	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
595495012103	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
595495012104	NAD binding site [chemical binding]; other site
595495012105	catalytic residues [active]
595495012106	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
595495012107	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
595495012108	putative active site [active]
595495012109	putative metal binding site [ion binding]; other site
595495012110	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
595495012111	putative substrate binding pocket [chemical binding]; other site
595495012112	trimer interface [polypeptide binding]; other site
595495012113	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
595495012114	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
595495012115	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495012116	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
595495012117	putative substrate translocation pore; other site
595495012118	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
595495012119	Cupin domain; Region: Cupin_2; pfam07883
595495012120	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495012121	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
595495012122	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
595495012123	4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486
595495012124	carbon starvation protein A; Provisional; Region: PRK15015
595495012125	Carbon starvation protein CstA; Region: CstA; pfam02554
595495012126	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
595495012127	Uncharacterized small protein [Function unknown]; Region: COG2879
595495012128	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
595495012129	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
595495012130	P-loop, Walker A motif; other site
595495012131	Base recognition motif; other site
595495012132	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
595495012133	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
595495012134	Penicillin amidase; Region: Penicil_amidase; pfam01804
595495012135	Penicillin G acylase (PGA) is the key enzyme in the industrial production of beta-lactam antibiotics. PGA hydrolyzes the side chain of penicillin G and related beta-lactam antibiotics releasing 6-amino penicillanic acid (6-APA), a building block in the...; Region: Ntn_PGA; cd03748
595495012136	active site
595495012137	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
595495012138	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
595495012139	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495012140	DNA-binding site [nucleotide binding]; DNA binding site
595495012141	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
595495012142	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495012143	homodimer interface [polypeptide binding]; other site
595495012144	catalytic residue [active]
595495012145	putative transposase; Provisional; Region: PRK09857
595495012146	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
595495012147	multidrug efflux system protein MdtM; Provisional; Region: PRK15403
595495012148	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495012149	putative substrate translocation pore; other site
595495012150	Predicted membrane protein [Function unknown]; Region: COG2733
595495012151	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
595495012152	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
595495012153	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
595495012154	CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241
595495012155	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
595495012156	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204
595495012157	SdiA-regulated; Region: SdiA-regulated; cd09971
595495012158	putative active site [active]
595495012159	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
595495012160	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
595495012161	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
595495012162	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
595495012163	Nucleoside recognition; Region: Gate; pfam07670
595495012164	hypothetical protein; Provisional; Region: PRK10519
595495012165	Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308
595495012166	isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975
595495012167	dimer interface [polypeptide binding]; other site
595495012168	active site
595495012169	cell density-dependent motility repressor; Provisional; Region: PRK10082
595495012170	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495012171	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
595495012172	DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128
595495012173	Protein of unknown function (DUF2686); Region: DUF2686; pfam10887
595495012174	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
595495012175	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495012176	DNA-binding site [nucleotide binding]; DNA binding site
595495012177	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
595495012178	D-mannonate oxidoreductase; Provisional; Region: PRK15037
595495012179	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
595495012180	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
595495012181	mannonate dehydratase; Region: uxuA; TIGR00695
595495012182	mannonate dehydratase; Provisional; Region: PRK03906
595495012183	fructuronate transporter; Provisional; Region: PRK10034
595495012184	gluconate transporter; Region: gntP; TIGR00791
595495012185	Mannose binding  domain of FimH and related proteins; Region: FimH_man-bind; cd10466
595495012186	mannosyl binding site [chemical binding]; other site
595495012187	Fimbrial protein; Region: Fimbrial; pfam00419
595495012188	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
595495012189	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
595495012190	outer membrane usher protein; Provisional; Region: PRK15193
595495012191	PapC N-terminal domain; Region: PapC_N; pfam13954
595495012192	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
595495012193	PapC C-terminal domain; Region: PapC_C; pfam13953
595495012194	fimbrial chaperone protein FimC; Provisional; Region: PRK15195
595495012195	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
595495012196	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
595495012197	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
595495012198	Fimbrial protein; Region: Fimbrial; cl01416
595495012199	FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197
595495012200	Int/Topo IB signature motif; other site
595495012201	FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197
595495012202	Int/Topo IB signature motif; other site
595495012203	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
595495012204	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
595495012205	Kelch motif; Region: Kelch_1; pfam01344
595495012206	Domain of unknown function (DUF303); Region: DUF303; pfam03629
595495012207	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
595495012208	HNH endonuclease; Region: HNH_2; pfam13391
595495012209	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
595495012210	McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117
595495012211	Methyltransferase domain; Region: Methyltransf_26; pfam13659
595495012212	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
595495012213	HerA helicase [Replication, recombination, and repair]; Region: COG0433
595495012214	Domain of unknown function DUF87; Region: DUF87; pfam01935
595495012215	Protein kinase domain; Region: Pkinase; pfam00069
595495012216	Catalytic domain of Protein Kinases; Region: PKc; cd00180
595495012217	active site
595495012218	ATP binding site [chemical binding]; other site
595495012219	substrate binding site [chemical binding]; other site
595495012220	activation loop (A-loop); other site
595495012221	integrase; Provisional; Region: PRK09692
595495012222	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
595495012223	active site
595495012224	Int/Topo IB signature motif; other site
595495012225	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
595495012226	Methyltransferase domain; Region: Methyltransf_27; pfam13708
595495012227	Protein of unknown function (DUF1219); Region: DUF1219; pfam06755
595495012228	YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154
595495012229	hypothetical protein; Reviewed; Region: PRK00024
595495012230	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
595495012231	MPN+ (JAMM) motif; other site
595495012232	Zinc-binding site [ion binding]; other site
595495012233	Domain of unknown function (DUF932); Region: DUF932; pfam06067
595495012234	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
595495012235	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
595495012236	Predicted GTPase [General function prediction only]; Region: COG3596
595495012237	YfjP GTPase; Region: YfjP; cd11383
595495012238	G1 box; other site
595495012239	GTP/Mg2+ binding site [chemical binding]; other site
595495012240	Switch I region; other site
595495012241	G2 box; other site
595495012242	Switch II region; other site
595495012243	G3 box; other site
595495012244	G4 box; other site
595495012245	Predicted transcriptional regulator [Transcription]; Region: COG2378
595495012246	WYL domain; Region: WYL; cl14852
595495012247	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
595495012248	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
595495012249	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
595495012250	ATP binding site [chemical binding]; other site
595495012251	putative Mg++ binding site [ion binding]; other site
595495012252	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
595495012253	HsdM N-terminal domain; Region: HsdM_N; pfam12161
595495012254	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
595495012255	Methyltransferase domain; Region: Methyltransf_26; pfam13659
595495012256	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
595495012257	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
595495012258	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
595495012259	active site
595495012260	catalytic triad [active]
595495012261	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
595495012262	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
595495012263	HNH endonuclease; Region: HNH_2; pfam13391
595495012264	integrase; Provisional; Region: PRK09692
595495012265	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
595495012266	active site
595495012267	Int/Topo IB signature motif; other site
595495012268	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
595495012269	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
595495012270	putative NAD(P) binding site [chemical binding]; other site
595495012271	putative substrate binding site [chemical binding]; other site
595495012272	catalytic Zn binding site [ion binding]; other site
595495012273	structural Zn binding site [ion binding]; other site
595495012274	dimer interface [polypeptide binding]; other site
595495012275	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
595495012276	ATP-binding site [chemical binding]; other site
595495012277	Gluconate-6-phosphate binding site [chemical binding]; other site
595495012278	Shikimate kinase; Region: SKI; pfam01202
595495012279	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
595495012280	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
595495012281	putative NAD(P) binding site [chemical binding]; other site
595495012282	catalytic Zn binding site [ion binding]; other site
595495012283	gluconate 5-dehydrogenase; Provisional; Region: PRK08085
595495012284	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
595495012285	NADP binding site [chemical binding]; other site
595495012286	homodimer interface [polypeptide binding]; other site
595495012287	active site
595495012288	fructuronate transporter; Provisional; Region: PRK10034; cl15264
595495012289	gluconate transporter; Region: gntP; TIGR00791
595495012290	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
595495012291	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
595495012292	DNA binding site [nucleotide binding]
595495012293	domain linker motif; other site
595495012294	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
595495012295	putative dimerization interface [polypeptide binding]; other site
595495012296	putative ligand binding site [chemical binding]; other site
595495012297	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
595495012298	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
595495012299	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
595495012300	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
595495012301	lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120
595495012302	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
595495012303	multifunctional aminopeptidase A; Provisional; Region: PRK00913
595495012304	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
595495012305	interface (dimer of trimers) [polypeptide binding]; other site
595495012306	Substrate-binding/catalytic site; other site
595495012307	Zn-binding sites [ion binding]; other site
595495012308	DNA polymerase III subunit chi; Validated; Region: PRK05728
595495012309	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
595495012310	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
595495012311	HIGH motif; other site
595495012312	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
595495012313	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
595495012314	active site
595495012315	KMSKS motif; other site
595495012316	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
595495012317	tRNA binding surface [nucleotide binding]; other site
595495012318	anticodon binding site; other site
595495012319	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
595495012320	Predicted membrane protein [Function unknown]; Region: COG4269
595495012321	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
595495012322	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
595495012323	Coenzyme A binding pocket [chemical binding]; other site
595495012324	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076
595495012325	RNase E inhibitor protein; Provisional; Region: PRK11191
595495012326	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
595495012327	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
595495012328	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
595495012329	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
595495012330	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
595495012331	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
595495012332	oxidoreductase; Provisional; Region: PRK12742
595495012333	classical (c) SDRs; Region: SDR_c; cd05233
595495012334	NAD(P) binding site [chemical binding]; other site
595495012335	active site
595495012336	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
595495012337	homotrimer interaction site [polypeptide binding]; other site
595495012338	putative active site [active]
595495012339	PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052
595495012340	aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670
595495012341	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
595495012342	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
595495012343	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
595495012344	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
595495012345	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
595495012346	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
595495012347	homotrimer interaction site [polypeptide binding]; other site
595495012348	putative active site [active]
595495012349	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
595495012350	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
595495012351	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
595495012352	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
595495012353	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495012354	motif II; other site
595495012355	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
595495012356	trehalose repressor; Provisional; Region: treR; PRK09492
595495012357	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
595495012358	DNA binding site [nucleotide binding]
595495012359	domain linker motif; other site
595495012360	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
595495012361	dimerization interface [polypeptide binding]; other site
595495012362	ligand binding site [chemical binding]; other site
595495012363	PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007
595495012364	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
595495012365	active site turn [active]
595495012366	phosphorylation site [posttranslational modification]
595495012367	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
595495012368	trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933
595495012369	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
595495012370	Ca binding site [ion binding]; other site
595495012371	active site
595495012372	catalytic site [active]
595495012373	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
595495012374	ATP cone domain; Region: ATP-cone; pfam03477
595495012375	Class III ribonucleotide reductase; Region: RNR_III; cd01675
595495012376	effector binding site; other site
595495012377	active site
595495012378	Zn binding site [ion binding]; other site
595495012379	glycine loop; other site
595495012380	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
595495012381	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
595495012382	FeS/SAM binding site; other site
595495012383	cytochrome b562; Provisional; Region: PRK15058
595495012384	peptidase PmbA; Provisional; Region: PRK11040
595495012385	hypothetical protein; Provisional; Region: PRK05255
595495012386	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
595495012387	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
595495012388	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
595495012389	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
595495012390	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
595495012391	AMP binding site [chemical binding]; other site
595495012392	metal binding site [ion binding]; metal-binding site
595495012393	active site
595495012394	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
595495012395	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
595495012396	TM-ABC transporter signature motif; other site
595495012397	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
595495012398	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
595495012399	TM-ABC transporter signature motif; other site
595495012400	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
595495012401	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
595495012402	Walker A/P-loop; other site
595495012403	ATP binding site [chemical binding]; other site
595495012404	Q-loop/lid; other site
595495012405	ABC transporter signature motif; other site
595495012406	Walker B; other site
595495012407	D-loop; other site
595495012408	H-loop/switch region; other site
595495012409	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
595495012410	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
595495012411	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
595495012412	putative ligand binding site [chemical binding]; other site
595495012413	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
595495012414	dimer interface [polypeptide binding]; other site
595495012415	substrate binding site [chemical binding]; other site
595495012416	metal binding sites [ion binding]; metal-binding site
595495012417	toxin ChpB; Provisional; Region: PRK09812
595495012418	antitoxin ChpS; Provisional; Region: PRK11347
595495012419	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
595495012420	putative active site pocket [active]
595495012421	dimerization interface [polypeptide binding]; other site
595495012422	putative catalytic residue [active]
595495012423	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
595495012424	Family of unknown function (DUF490); Region: DUF490; pfam04357
595495012425	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
595495012426	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
595495012427	Surface antigen; Region: Bac_surface_Ag; pfam01103
595495012428	methionine sulfoxide reductase A; Provisional; Region: PRK00058
595495012429	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
595495012430	Domain of unknown function DUF21; Region: DUF21; pfam01595
595495012431	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
595495012432	Transporter associated domain; Region: CorC_HlyC; smart01091
595495012433	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
595495012434	Predicted transcriptional regulator [General function prediction only]; Region: COG3054
595495012435	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
595495012436	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
595495012437	active site
595495012438	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
595495012439	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
595495012440	active site
595495012441	metal binding site [ion binding]; metal-binding site
595495012442	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
595495012443	Predicted transcriptional regulators [Transcription]; Region: COG1733
595495012444	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
595495012445	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
595495012446	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
595495012447	NADP binding site [chemical binding]; other site
595495012448	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
595495012449	EamA-like transporter family; Region: EamA; pfam00892
595495012450	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
595495012451	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
595495012452	Hemerythrin-like domain; Region: Hr-like; cd12108
595495012453	Fe binding site [ion binding]; other site
595495012454	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
595495012455	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
595495012456	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
595495012457	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
595495012458	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
595495012459	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
595495012460	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
595495012461	Probable transposase; Region: OrfB_IS605; pfam01385
595495012462	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
595495012463	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
595495012464	Protein of unknown function (DUF2686); Region: DUF2686; pfam10887
595495012465	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
595495012466	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
595495012467	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
595495012468	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
595495012469	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
595495012470	dimer interface [polypeptide binding]; other site
595495012471	ssDNA binding site [nucleotide binding]; other site
595495012472	tetramer (dimer of dimers) interface [polypeptide binding]; other site
595495012473	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
595495012474	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
595495012475	Protein of unknown function (DUF1440); Region: DUF1440; pfam07274
595495012476	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
595495012477	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
595495012478	intersubunit interface [polypeptide binding]; other site
595495012479	active site
595495012480	Zn2+ binding site [ion binding]; other site
595495012481	L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209
595495012482	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
595495012483	AP (apurinic/apyrimidinic) site pocket; other site
595495012484	DNA interaction; other site
595495012485	Metal-binding active site; metal-binding site
595495012486	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
595495012487	active site
595495012488	dimer interface [polypeptide binding]; other site
595495012489	magnesium binding site [ion binding]; other site
595495012490	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
595495012491	active site
595495012492	phosphorylation site [posttranslational modification]
595495012493	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
595495012494	PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548
595495012495	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
595495012496	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
595495012497	transcriptional repressor UlaR; Provisional; Region: PRK13509
595495012498	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
595495012499	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
595495012500	esterase; Provisional; Region: PRK10566
595495012501	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
595495012502	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
595495012503	putative biofilm stress and motility protein A; Provisional; Region: PRK14864
595495012504	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
595495012505	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
595495012506	Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154
595495012507	FAD binding site [chemical binding]; other site
595495012508	substrate binding site [chemical binding]; other site
595495012509	catalytic residues [active]
595495012510	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
595495012511	Predicted integral membrane protein [Function unknown]; Region: COG5463
595495012512	Predicted membrane protein [Function unknown]; Region: COG3766
595495012513	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
595495012514	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
595495012515	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
595495012516	PspA/IM30 family; Region: PspA_IM30; pfam04012
595495012517	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551
595495012518	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
595495012519	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
595495012520	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
595495012521	exoribonuclease R; Provisional; Region: PRK11642
595495012522	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
595495012523	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
595495012524	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
595495012525	RNB domain; Region: RNB; pfam00773
595495012526	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
595495012527	RNA binding site [nucleotide binding]; other site
595495012528	Predicted transcriptional regulator [Transcription]; Region: COG1959
595495012529	transcriptional repressor NsrR; Provisional; Region: PRK11014
595495012530	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
595495012531	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
595495012532	GDP-binding site [chemical binding]; other site
595495012533	ACT binding site; other site
595495012534	IMP binding site; other site
595495012535	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
595495012536	FtsH protease regulator HflC; Provisional; Region: PRK11029
595495012537	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
595495012538	FtsH protease regulator HflK; Provisional; Region: PRK10930
595495012539	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
595495012540	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
595495012541	GTPase HflX; Provisional; Region: PRK11058
595495012542	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
595495012543	HflX GTPase family; Region: HflX; cd01878
595495012544	G1 box; other site
595495012545	GTP/Mg2+ binding site [chemical binding]; other site
595495012546	Switch I region; other site
595495012547	G2 box; other site
595495012548	G3 box; other site
595495012549	Switch II region; other site
595495012550	G4 box; other site
595495012551	G5 box; other site
595495012552	bacterial Hfq-like; Region: Hfq; cd01716
595495012553	hexamer interface [polypeptide binding]; other site
595495012554	Sm1 motif; other site
595495012555	RNA binding site [nucleotide binding]; other site
595495012556	Sm2 motif; other site
595495012557	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
595495012558	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
595495012559	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
595495012560	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495012561	ATP binding site [chemical binding]; other site
595495012562	Mg2+ binding site [ion binding]; other site
595495012563	G-X-G motif; other site
595495012564	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
595495012565	ATP binding site [chemical binding]; other site
595495012566	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
595495012567	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
595495012568	AMIN domain; Region: AMIN; pfam11741
595495012569	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
595495012570	active site
595495012571	metal binding site [ion binding]; metal-binding site
595495012572	ADP-binding protein; Provisional; Region: PRK10646
595495012573	putative carbohydrate kinase; Provisional; Region: PRK10565
595495012574	yjeF N-terminal region; Region: yjeF_nterm; TIGR00197
595495012575	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
595495012576	putative substrate binding site [chemical binding]; other site
595495012577	putative ATP binding site [chemical binding]; other site
595495012578	epoxyqueuosine reductase; Region: TIGR00276
595495012579	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
595495012580	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
595495012581	catalytic site [active]
595495012582	putative active site [active]
595495012583	putative substrate binding site [chemical binding]; other site
595495012584	dimer interface [polypeptide binding]; other site
595495012585	GTPase RsgA; Reviewed; Region: PRK12288
595495012586	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
595495012587	RNA binding site [nucleotide binding]; other site
595495012588	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
595495012589	GTPase/Zn-binding domain interface [polypeptide binding]; other site
595495012590	GTP/Mg2+ binding site [chemical binding]; other site
595495012591	G4 box; other site
595495012592	G5 box; other site
595495012593	G1 box; other site
595495012594	Switch I region; other site
595495012595	G2 box; other site
595495012596	G3 box; other site
595495012597	Switch II region; other site
595495012598	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
595495012599	putative mechanosensitive channel protein; Provisional; Region: PRK10929
595495012600	linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073
595495012601	DNA-binding site [nucleotide binding]; DNA binding site
595495012602	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
595495012603	Mechanosensitive ion channel; Region: MS_channel; pfam00924
595495012604	Protein of unknown function (DUF2645); Region: DUF2645; pfam10840
595495012605	inner membrane transporter YjeM; Provisional; Region: PRK15238
595495012606	poxB regulator PoxA; Provisional; Region: PRK09350
595495012607	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
595495012608	motif 1; other site
595495012609	dimer interface [polypeptide binding]; other site
595495012610	active site
595495012611	motif 2; other site
595495012612	motif 3; other site
595495012613	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
595495012614	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
595495012615	Mu DNA binding, I gamma subdomain; Region: HTH_Tnp_Mu_2; pfam09039
595495012616	Bacteriophage Mu transposase; Region: DDE_2; pfam02914
595495012617	Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423
595495012618	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
595495012619	succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812
595495012620	L-aspartate oxidase; Provisional; Region: PRK06175
595495012621	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
595495012622	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
595495012623	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
595495012624	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
595495012625	D-subunit interface [polypeptide binding]; other site
595495012626	Iron-sulfur protein interface; other site
595495012627	proximal quinone binding site [chemical binding]; other site
595495012628	distal quinone binding site [chemical binding]; other site
595495012629	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
595495012630	Iron-sulfur protein interface; other site
595495012631	proximal quinone binding site [chemical binding]; other site
595495012632	C-subunit interface; other site
595495012633	distal quinone binding site; other site
595495012634	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
595495012635	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
595495012636	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
595495012637	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
595495012638	multidrug efflux system protein; Provisional; Region: PRK11431
595495012639	entericidin B membrane lipoprotein; Provisional; Region: PRK10081
595495012640	entericidin A; Provisional; Region: PRK09810
595495012641	elongation factor P; Validated; Region: PRK00529
595495012642	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
595495012643	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
595495012644	RNA binding site [nucleotide binding]; other site
595495012645	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
595495012646	RNA binding site [nucleotide binding]; other site
595495012647	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
595495012648	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
595495012649	FeS/SAM binding site; other site
595495012650	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
595495012651	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
595495012652	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
595495012653	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
595495012654	ring oligomerisation interface [polypeptide binding]; other site
595495012655	ATP/Mg binding site [chemical binding]; other site
595495012656	stacking interactions; other site
595495012657	hinge regions; other site
595495012658	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
595495012659	oligomerisation interface [polypeptide binding]; other site
595495012660	mobile loop; other site
595495012661	roof hairpin; other site
595495012662	putative transporter; Provisional; Region: PRK11021
595495012663	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
595495012664	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
595495012665	Aspartase; Region: Aspartase; cd01357
595495012666	active sites [active]
595495012667	tetramer interface [polypeptide binding]; other site
595495012668	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
595495012669	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
595495012670	divalent-cation tolerance protein CutA; Provisional; Region: PRK10645
595495012671	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
595495012672	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
595495012673	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
595495012674	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
595495012675	DsbD alpha interface [polypeptide binding]; other site
595495012676	catalytic residues [active]
595495012677	putative transcriptional regulator; Provisional; Region: PRK11640
595495012678	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
595495012679	DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153
595495012680	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
595495012681	DNA binding site [nucleotide binding]
595495012682	lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435
595495012683	lysine decarboxylase CadA; Provisional; Region: PRK15400
595495012684	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
595495012685	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
595495012686	homodimer interface [polypeptide binding]; other site
595495012687	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495012688	catalytic residue [active]
595495012689	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
595495012690	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
595495012691	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495012692	putative substrate translocation pore; other site
595495012693	POT family; Region: PTR2; pfam00854
595495012694	lysyl-tRNA synthetase; Reviewed; Region: PRK12445
595495012695	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
595495012696	dimer interface [polypeptide binding]; other site
595495012697	putative anticodon binding site; other site
595495012698	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
595495012699	motif 1; other site
595495012700	active site
595495012701	motif 2; other site
595495012702	motif 3; other site
595495012703	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
595495012704	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
595495012705	Predicted acetyltransferase [General function prediction only]; Region: COG2388
595495012706	Uncharacterized conserved protein [Function unknown]; Region: COG3592
595495012707	sensory histidine kinase DcuS; Provisional; Region: PRK11086
595495012708	PAS domain; Region: PAS; smart00091
595495012709	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495012710	ATP binding site [chemical binding]; other site
595495012711	Mg2+ binding site [ion binding]; other site
595495012712	G-X-G motif; other site
595495012713	DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430
595495012714	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495012715	active site
595495012716	phosphorylation site [posttranslational modification]
595495012717	intermolecular recognition site; other site
595495012718	dimerization interface [polypeptide binding]; other site
595495012719	Transcriptional regulator; Region: CitT; pfam12431
595495012720	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
595495012721	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
595495012722	fumarate hydratase; Provisional; Region: PRK15389
595495012723	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
595495012724	Fumarase C-terminus; Region: Fumerase_C; pfam05683
595495012725	hypothetical protein; Provisional; Region: PRK09867
595495012726	melibiose:sodium symporter; Provisional; Region: PRK10429
595495012727	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
595495012728	alpha-galactosidase; Provisional; Region: PRK15076
595495012729	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
595495012730	NAD binding site [chemical binding]; other site
595495012731	sugar binding site [chemical binding]; other site
595495012732	divalent metal binding site [ion binding]; other site
595495012733	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
595495012734	dimer interface [polypeptide binding]; other site
595495012735	DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371
595495012736	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495012737	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495012738	arginine decarboxylase; Provisional; Region: PRK15029
595495012739	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
595495012740	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
595495012741	homodimer interface [polypeptide binding]; other site
595495012742	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495012743	catalytic residue [active]
595495012744	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
595495012745	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
595495012746	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495012747	arginine:agmatin antiporter; Provisional; Region: PRK10644
595495012748	putative metal dependent hydrolase; Provisional; Region: PRK11598
595495012749	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
595495012750	Sulfatase; Region: Sulfatase; pfam00884
595495012751	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
595495012752	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495012753	active site
595495012754	phosphorylation site [posttranslational modification]
595495012755	intermolecular recognition site; other site
595495012756	dimerization interface [polypeptide binding]; other site
595495012757	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
595495012758	DNA binding site [nucleotide binding]
595495012759	sensor protein BasS/PmrB; Provisional; Region: PRK10755
595495012760	HAMP domain; Region: HAMP; pfam00672
595495012761	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
595495012762	dimer interface [polypeptide binding]; other site
595495012763	phosphorylation site [posttranslational modification]
595495012764	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495012765	ATP binding site [chemical binding]; other site
595495012766	Mg2+ binding site [ion binding]; other site
595495012767	G-X-G motif; other site
595495012768	proline/glycine betaine transporter; Provisional; Region: PRK10642
595495012769	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495012770	putative substrate translocation pore; other site
595495012771	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
595495012772	YjcZ-like protein; Region: YjcZ; pfam13990
595495012773	hypothetical protein; Provisional; Region: PRK09866
595495012774	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
595495012775	G1 box; other site
595495012776	GTP/Mg2+ binding site [chemical binding]; other site
595495012777	G2 box; other site
595495012778	Switch I region; other site
595495012779	G3 box; other site
595495012780	Switch II region; other site
595495012781	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
595495012782	G2 box; other site
595495012783	Switch I region; other site
595495012784	G3 box; other site
595495012785	Switch II region; other site
595495012786	G4 box; other site
595495012787	G5 box; other site
595495012788	hypothetical protein; Provisional; Region: PRK10220
595495012789	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
595495012790	PhnA protein; Region: PhnA; pfam03831
595495012791	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
595495012792	dimer interface [polypeptide binding]; other site
595495012793	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
595495012794	phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984
595495012795	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
595495012796	Walker A/P-loop; other site
595495012797	ATP binding site [chemical binding]; other site
595495012798	Q-loop/lid; other site
595495012799	ABC transporter signature motif; other site
595495012800	Walker B; other site
595495012801	D-loop; other site
595495012802	H-loop/switch region; other site
595495012803	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
595495012804	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
595495012805	substrate binding pocket [chemical binding]; other site
595495012806	membrane-bound complex binding site; other site
595495012807	hinge residues; other site
595495012808	phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079
595495012809	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495012810	DNA-binding site [nucleotide binding]; DNA binding site
595495012811	UTRA domain; Region: UTRA; pfam07702
595495012812	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
595495012813	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625
595495012814	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626
595495012815	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627
595495012816	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
595495012817	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
595495012818	Walker A/P-loop; other site
595495012819	ATP binding site [chemical binding]; other site
595495012820	Q-loop/lid; other site
595495012821	ABC transporter signature motif; other site
595495012822	Walker B; other site
595495012823	D-loop; other site
595495012824	H-loop/switch region; other site
595495012825	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
595495012826	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
595495012827	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
595495012828	Walker A/P-loop; other site
595495012829	ATP binding site [chemical binding]; other site
595495012830	Q-loop/lid; other site
595495012831	ABC transporter signature motif; other site
595495012832	Walker B; other site
595495012833	D-loop; other site
595495012834	H-loop/switch region; other site
595495012835	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
595495012836	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
595495012837	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
595495012838	active site
595495012839	ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078
595495012840	AAA domain; Region: AAA_18; pfam13238
595495012841	active site
595495012842	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
595495012843	Coenzyme A binding pocket [chemical binding]; other site
595495012844	carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244
595495012845	ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120
595495012846	DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337
595495012847	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
595495012848	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
595495012849	putative active site [active]
595495012850	D-allose transporter subunit; Provisional; Region: PRK09701
595495012851	Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320
595495012852	ligand binding site [chemical binding]; other site
595495012853	dimerization interface [polypeptide binding]; other site
595495012854	zinc binding site [ion binding]; other site
595495012855	D-allose transporter ATP-binding protein; Provisional; Region: PRK09700
595495012856	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495012857	Walker A/P-loop; other site
595495012858	ATP binding site [chemical binding]; other site
595495012859	Q-loop/lid; other site
595495012860	ABC transporter signature motif; other site
595495012861	Walker B; other site
595495012862	D-loop; other site
595495012863	H-loop/switch region; other site
595495012864	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
595495012865	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
595495012866	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
595495012867	TM-ABC transporter signature motif; other site
595495012868	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
595495012869	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
595495012870	substrate binding site [chemical binding]; other site
595495012871	hexamer interface [polypeptide binding]; other site
595495012872	metal binding site [ion binding]; metal-binding site
595495012873	D-allose kinase; Provisional; Region: PRK09698
595495012874	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
595495012875	nucleotide binding site [chemical binding]; other site
595495012876	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
595495012877	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
595495012878	multidrug resistance protein MdtN; Provisional; Region: PRK10476
595495012879	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
595495012880	HlyD family secretion protein; Region: HlyD_3; pfam13437
595495012881	multidrug efflux system protein MdtO; Provisional; Region: PRK11427
595495012882	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
595495012883	putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915
595495012884	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
595495012885	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
595495012886	[4Fe-4S] binding site [ion binding]; other site
595495012887	molybdopterin cofactor binding site; other site
595495012888	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
595495012889	molybdopterin cofactor binding site; other site
595495012890	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
595495012891	Sel1-like repeats; Region: SEL1; smart00671
595495012892	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
595495012893	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
595495012894	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
595495012895	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
595495012896	binding surface
595495012897	TPR motif; other site
595495012898	formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144
595495012899	heme lyase subunit NrfE; Provisional; Region: PRK10369
595495012900	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
595495012901	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
595495012902	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
595495012903	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
595495012904	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
595495012905	acetyl-CoA synthetase; Provisional; Region: PRK00174
595495012906	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
595495012907	active site
595495012908	CoA binding site [chemical binding]; other site
595495012909	acyl-activating enzyme (AAE) consensus motif; other site
595495012910	AMP binding site [chemical binding]; other site
595495012911	acetate binding site [chemical binding]; other site
595495012912	Predicted membrane protein [Function unknown]; Region: COG3162
595495012913	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
595495012914	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
595495012915	Na binding site [ion binding]; other site
595495012916	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
595495012917	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
595495012918	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
595495012919	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
595495012920	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
595495012921	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
595495012922	redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002
595495012923	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
595495012924	DNA binding residues [nucleotide binding]
595495012925	dimer interface [polypeptide binding]; other site
595495012926	[2Fe-2S] cluster binding site [ion binding]; other site
595495012927	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
595495012928	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495012929	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
595495012930	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
595495012931	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
595495012932	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
595495012933	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
595495012934	dimer interface [polypeptide binding]; other site
595495012935	ssDNA binding site [nucleotide binding]; other site
595495012936	tetramer (dimer of dimers) interface [polypeptide binding]; other site
595495012937	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
595495012938	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
595495012939	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
595495012940	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
595495012941	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
595495012942	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
595495012943	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
595495012944	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495012945	active site
595495012946	motif I; other site
595495012947	motif II; other site
595495012948	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
595495012949	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
595495012950	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495012951	homodimer interface [polypeptide binding]; other site
595495012952	catalytic residue [active]
595495012953	alanine racemase; Reviewed; Region: alr; PRK00053
595495012954	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
595495012955	active site
595495012956	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
595495012957	substrate binding site [chemical binding]; other site
595495012958	catalytic residues [active]
595495012959	dimer interface [polypeptide binding]; other site
595495012960	replicative DNA helicase; Provisional; Region: PRK08006
595495012961	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
595495012962	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
595495012963	Walker A motif; other site
595495012964	ATP binding site [chemical binding]; other site
595495012965	Walker B motif; other site
595495012966	DNA binding loops [nucleotide binding]
595495012967	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
595495012968	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
595495012969	NADP binding site [chemical binding]; other site
595495012970	dimer interface [polypeptide binding]; other site
595495012971	phage shock protein G; Reviewed; Region: pspG; PRK09459
595495012972	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
595495012973	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
595495012974	FMN binding site [chemical binding]; other site
595495012975	active site
595495012976	catalytic residues [active]
595495012977	substrate binding site [chemical binding]; other site
595495012978	Protein of unknown function (DUF2713); Region: DUF2713; pfam10897
595495012979	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
595495012980	metal binding site 2 [ion binding]; metal-binding site
595495012981	putative DNA binding helix; other site
595495012982	metal binding site 1 [ion binding]; metal-binding site
595495012983	dimer interface [polypeptide binding]; other site
595495012984	structural Zn2+ binding site [ion binding]; other site
595495012985	hypothetical protein; Provisional; Region: PRK10428
595495012986	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
595495012987	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
595495012988	LexA repressor; Validated; Region: PRK00215
595495012989	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
595495012990	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
595495012991	Catalytic site [active]
595495012992	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
595495012993	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
595495012994	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
595495012995	putative acyl-acceptor binding pocket; other site
595495012996	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
595495012997	UbiA prenyltransferase family; Region: UbiA; pfam01040
595495012998	chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655
595495012999	hypothetical protein; Validated; Region: PRK09718
595495013000	maltose regulon periplasmic protein; Provisional; Region: PRK10564
595495013001	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
595495013002	trimer interface; other site
595495013003	sugar binding site [chemical binding]; other site
595495013004	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
595495013005	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
595495013006	Walker A/P-loop; other site
595495013007	ATP binding site [chemical binding]; other site
595495013008	Q-loop/lid; other site
595495013009	ABC transporter signature motif; other site
595495013010	Walker B; other site
595495013011	D-loop; other site
595495013012	H-loop/switch region; other site
595495013013	TOBE domain; Region: TOBE_2; pfam08402
595495013014	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
595495013015	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
595495013016	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
595495013017	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495013018	dimer interface [polypeptide binding]; other site
595495013019	conserved gate region; other site
595495013020	putative PBP binding loops; other site
595495013021	ABC-ATPase subunit interface; other site
595495013022	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
595495013023	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495013024	dimer interface [polypeptide binding]; other site
595495013025	conserved gate region; other site
595495013026	putative PBP binding loops; other site
595495013027	ABC-ATPase subunit interface; other site
595495013028	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
595495013029	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495013030	putative substrate translocation pore; other site
595495013031	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495013032	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
595495013033	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
595495013034	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
595495013035	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
595495013036	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
595495013037	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
595495013038	active site
595495013039	dimer interface [polypeptide binding]; other site
595495013040	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
595495013041	dimer interface [polypeptide binding]; other site
595495013042	active site
595495013043	aspartate kinase III; Validated; Region: PRK09084
595495013044	AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258
595495013045	nucleotide binding site [chemical binding]; other site
595495013046	putative catalytic residues [active]
595495013047	aspartate binding site [chemical binding]; other site
595495013048	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932
595495013049	lysine allosteric regulatory site; other site
595495013050	dimer interface [polypeptide binding]; other site
595495013051	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
595495013052	dimer interface [polypeptide binding]; other site
595495013053	Zeta toxin; Region: Zeta_toxin; pfam06414
595495013054	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
595495013055	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
595495013056	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
595495013057	hypothetical protein; Provisional; Region: PRK10515
595495013058	23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475
595495013059	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
595495013060	RNA binding surface [nucleotide binding]; other site
595495013061	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
595495013062	probable active site [active]
595495013063	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
595495013064	active site pocket [active]
595495013065	oxyanion hole [active]
595495013066	catalytic triad [active]
595495013067	active site nucleophile [active]
595495013068	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
595495013069	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
595495013070	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
595495013071	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
595495013072	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
595495013073	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
595495013074	substrate binding pocket [chemical binding]; other site
595495013075	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
595495013076	B12 binding site [chemical binding]; other site
595495013077	cobalt ligand [ion binding]; other site
595495013078	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
595495013079	transcriptional repressor IclR; Provisional; Region: PRK11569
595495013080	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
595495013081	Bacterial transcriptional regulator; Region: IclR; pfam01614
595495013082	ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906
595495013083	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
595495013084	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
595495013085	isocitrate lyase; Provisional; Region: PRK15063
595495013086	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
595495013087	tetramer interface [polypeptide binding]; other site
595495013088	active site
595495013089	Mg2+/Mn2+ binding site [ion binding]; other site
595495013090	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
595495013091	malate synthase A; Region: malate_syn_A; TIGR01344
595495013092	active site
595495013093	homoserine O-succinyltransferase; Provisional; Region: PRK05368
595495013094	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
595495013095	proposed active site lysine [active]
595495013096	conserved cys residue [active]
595495013097	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
595495013098	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
595495013099	Coenzyme A binding pocket [chemical binding]; other site
595495013100	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
595495013101	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
595495013102	purine monophosphate binding site [chemical binding]; other site
595495013103	dimer interface [polypeptide binding]; other site
595495013104	putative catalytic residues [active]
595495013105	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
595495013106	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
595495013107	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
595495013108	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
595495013109	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
595495013110	transcriptional regulatory protein ZraR; Provisional; Region: PRK10365
595495013111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495013112	active site
595495013113	phosphorylation site [posttranslational modification]
595495013114	intermolecular recognition site; other site
595495013115	dimerization interface [polypeptide binding]; other site
595495013116	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495013117	Walker A motif; other site
595495013118	ATP binding site [chemical binding]; other site
595495013119	Walker B motif; other site
595495013120	arginine finger; other site
595495013121	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
595495013122	sensor protein ZraS; Provisional; Region: PRK10364
595495013123	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
595495013124	dimer interface [polypeptide binding]; other site
595495013125	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495013126	ATP binding site [chemical binding]; other site
595495013127	Mg2+ binding site [ion binding]; other site
595495013128	G-X-G motif; other site
595495013129	zinc resistance protein; Provisional; Region: zraP; PRK11546
595495013130	dimer interface [polypeptide binding]; other site
595495013131	Protein of unknown function (DUF1481); Region: DUF1481; pfam07356
595495013132	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
595495013133	IHF dimer interface [polypeptide binding]; other site
595495013134	IHF - DNA interface [nucleotide binding]; other site
595495013135	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
595495013136	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
595495013137	Active_site [active]
595495013138	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
595495013139	substrate binding site [chemical binding]; other site
595495013140	active site
595495013141	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
595495013142	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
595495013143	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
595495013144	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
595495013145	putative NADH binding site [chemical binding]; other site
595495013146	putative active site [active]
595495013147	nudix motif; other site
595495013148	putative metal binding site [ion binding]; other site
595495013149	Regulator of sigma D [Transcription]; Region: Rsd; COG3160
595495013150	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
595495013151	ThiC-associated domain; Region: ThiC-associated; pfam13667
595495013152	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
595495013153	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
595495013154	thiamine phosphate binding site [chemical binding]; other site
595495013155	active site
595495013156	pyrophosphate binding site [ion binding]; other site
595495013157	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
595495013158	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
595495013159	ATP binding site [chemical binding]; other site
595495013160	substrate interface [chemical binding]; other site
595495013161	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
595495013162	thiS-thiF/thiG interaction site; other site
595495013163	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
595495013164	ThiS interaction site; other site
595495013165	putative active site [active]
595495013166	tetramer interface [polypeptide binding]; other site
595495013167	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
595495013168	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
595495013169	FeS/SAM binding site; other site
595495013170	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
595495013171	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
595495013172	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
595495013173	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
595495013174	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
595495013175	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
595495013176	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
595495013177	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
595495013178	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
595495013179	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
595495013180	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
595495013181	DNA binding site [nucleotide binding]
595495013182	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
595495013183	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
595495013184	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
595495013185	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
595495013186	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
595495013187	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
595495013188	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
595495013189	RPB3 interaction site [polypeptide binding]; other site
595495013190	RPB1 interaction site [polypeptide binding]; other site
595495013191	RPB11 interaction site [polypeptide binding]; other site
595495013192	RPB10 interaction site [polypeptide binding]; other site
595495013193	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
595495013194	core dimer interface [polypeptide binding]; other site
595495013195	peripheral dimer interface [polypeptide binding]; other site
595495013196	L10 interface [polypeptide binding]; other site
595495013197	L11 interface [polypeptide binding]; other site
595495013198	putative EF-Tu interaction site [polypeptide binding]; other site
595495013199	putative EF-G interaction site [polypeptide binding]; other site
595495013200	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
595495013201	23S rRNA interface [nucleotide binding]; other site
595495013202	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
595495013203	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
595495013204	mRNA/rRNA interface [nucleotide binding]; other site
595495013205	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
595495013206	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
595495013207	23S rRNA interface [nucleotide binding]; other site
595495013208	L7/L12 interface [polypeptide binding]; other site
595495013209	putative thiostrepton binding site; other site
595495013210	L25 interface [polypeptide binding]; other site
595495013211	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
595495013212	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
595495013213	putative homodimer interface [polypeptide binding]; other site
595495013214	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
595495013215	heterodimer interface [polypeptide binding]; other site
595495013216	homodimer interface [polypeptide binding]; other site
595495013217	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
595495013218	elongation factor Tu; Reviewed; Region: PRK00049
595495013219	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
595495013220	G1 box; other site
595495013221	GEF interaction site [polypeptide binding]; other site
595495013222	GTP/Mg2+ binding site [chemical binding]; other site
595495013223	Switch I region; other site
595495013224	G2 box; other site
595495013225	G3 box; other site
595495013226	Switch II region; other site
595495013227	G4 box; other site
595495013228	G5 box; other site
595495013229	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
595495013230	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
595495013231	Antibiotic Binding Site [chemical binding]; other site
595495013232	pantothenate kinase; Provisional; Region: PRK05439
595495013233	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
595495013234	ATP-binding site [chemical binding]; other site
595495013235	CoA-binding site [chemical binding]; other site
595495013236	Mg2+-binding site [ion binding]; other site
595495013237	Biotin operon repressor [Transcription]; Region: BirA; COG1654
595495013238	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
595495013239	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
595495013240	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
595495013241	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
595495013242	FAD binding domain; Region: FAD_binding_4; pfam01565
595495013243	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
595495013244	glutamate racemase; Provisional; Region: PRK00865
595495013245	vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641
595495013246	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
595495013247	N-terminal plug; other site
595495013248	ligand-binding site [chemical binding]; other site
595495013249	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
595495013250	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495013251	S-adenosylmethionine binding site [chemical binding]; other site
595495013252	hypothetical protein; Provisional; Region: PRK11056
595495013253	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
595495013254	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
595495013255	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
595495013256	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
595495013257	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
595495013258	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
595495013259	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495013260	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
595495013261	dimerization interface [polypeptide binding]; other site
595495013262	argininosuccinate lyase; Provisional; Region: PRK04833
595495013263	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
595495013264	active sites [active]
595495013265	tetramer interface [polypeptide binding]; other site
595495013266	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
595495013267	nucleotide binding site [chemical binding]; other site
595495013268	N-acetyl-L-glutamate binding site [chemical binding]; other site
595495013269	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
595495013270	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
595495013271	acetylornithine deacetylase; Provisional; Region: PRK05111
595495013272	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
595495013273	metal binding site [ion binding]; metal-binding site
595495013274	putative dimer interface [polypeptide binding]; other site
595495013275	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
595495013276	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
595495013277	hypothetical protein; Provisional; Region: PRK10649
595495013278	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
595495013279	Sulfatase; Region: Sulfatase; pfam00884
595495013280	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
595495013281	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495013282	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
595495013283	active site
595495013284	P-loop; other site
595495013285	phosphorylation site [posttranslational modification]
595495013286	pyruvate formate lyase II activase; Provisional; Region: PRK10076
595495013287	putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983
595495013288	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
595495013289	dimer interface [polypeptide binding]; other site
595495013290	active site
595495013291	glycine loop; other site
595495013292	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
595495013293	active site
595495013294	P-loop; other site
595495013295	phosphorylation site [posttranslational modification]
595495013296	putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478
595495013297	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
595495013298	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
595495013299	dimerization domain swap beta strand [polypeptide binding]; other site
595495013300	regulatory protein interface [polypeptide binding]; other site
595495013301	active site
595495013302	regulatory phosphorylation site [posttranslational modification]; other site
595495013303	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
595495013304	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
595495013305	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
595495013306	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
595495013307	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
595495013308	active site
595495013309	phosphorylation site [posttranslational modification]
595495013310	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
595495013311	active site
595495013312	intersubunit interactions; other site
595495013313	catalytic residue [active]
595495013314	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
595495013315	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
595495013316	dimer interface [polypeptide binding]; other site
595495013317	active site
595495013318	metal binding site [ion binding]; metal-binding site
595495013319	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738
595495013320	EamA-like transporter family; Region: EamA; pfam00892
595495013321	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
595495013322	EamA-like transporter family; Region: EamA; pfam00892
595495013323	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
595495013324	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
595495013325	heme binding site [chemical binding]; other site
595495013326	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
595495013327	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
595495013328	FAD binding site [chemical binding]; other site
595495013329	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
595495013330	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
595495013331	putative catalytic residues [active]
595495013332	putative nucleotide binding site [chemical binding]; other site
595495013333	putative aspartate binding site [chemical binding]; other site
595495013334	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
595495013335	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
595495013336	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
595495013337	cystathionine gamma-synthase; Provisional; Region: PRK08045
595495013338	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
595495013339	homodimer interface [polypeptide binding]; other site
595495013340	substrate-cofactor binding pocket; other site
595495013341	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495013342	catalytic residue [active]
595495013343	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
595495013344	dimerization interface [polypeptide binding]; other site
595495013345	DNA binding site [nucleotide binding]
595495013346	corepressor binding sites; other site
595495013347	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
595495013348	Transposase; Region: DEDD_Tnp_IS110; pfam01548
595495013349	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
595495013350	hypothetical protein; Provisional; Region: PRK10030
595495013351	PAAR motif; Region: PAAR_motif; cl15808
595495013352	RHS Repeat; Region: RHS_repeat; cl11982
595495013353	RHS Repeat; Region: RHS_repeat; pfam05593
595495013354	RHS Repeat; Region: RHS_repeat; cl11982
595495013355	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
595495013356	RHS Repeat; Region: RHS_repeat; pfam05593
595495013357	RHS Repeat; Region: RHS_repeat; pfam05593
595495013358	RHS protein; Region: RHS; pfam03527
595495013359	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
595495013360	Domain of unknown function (DUF4329); Region: DUF4329; pfam14220
595495013361	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
595495013362	primosome assembly protein PriA; Validated; Region: PRK05580
595495013363	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
595495013364	ATP binding site [chemical binding]; other site
595495013365	putative Mg++ binding site [ion binding]; other site
595495013366	helicase superfamily c-terminal domain; Region: HELICc; smart00490
595495013367	ATP-binding site [chemical binding]; other site
595495013368	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
595495013369	DNA binding site [nucleotide binding]
595495013370	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
595495013371	domain linker motif; other site
595495013372	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
595495013373	dimerization interface [polypeptide binding]; other site
595495013374	ligand binding site [chemical binding]; other site
595495013375	essential cell division protein FtsN; Provisional; Region: PRK10927
595495013376	cell division protein FtsN; Provisional; Region: PRK12757
595495013377	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
595495013378	active site
595495013379	HslU subunit interaction site [polypeptide binding]; other site
595495013380	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
595495013381	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495013382	Walker A motif; other site
595495013383	ATP binding site [chemical binding]; other site
595495013384	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
595495013385	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
595495013386	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751
595495013387	UbiA prenyltransferase family; Region: UbiA; pfam01040
595495013388	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
595495013389	septal ring assembly protein ZapB; Provisional; Region: PRK15422
595495013390	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
595495013391	amphipathic channel; other site
595495013392	Asn-Pro-Ala signature motifs; other site
595495013393	glycerol kinase; Provisional; Region: glpK; PRK00047
595495013394	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
595495013395	N- and C-terminal domain interface [polypeptide binding]; other site
595495013396	active site
595495013397	MgATP binding site [chemical binding]; other site
595495013398	catalytic site [active]
595495013399	metal binding site [ion binding]; metal-binding site
595495013400	glycerol binding site [chemical binding]; other site
595495013401	homotetramer interface [polypeptide binding]; other site
595495013402	homodimer interface [polypeptide binding]; other site
595495013403	FBP binding site [chemical binding]; other site
595495013404	protein IIAGlc interface [polypeptide binding]; other site
595495013405	ferredoxin-NADP reductase; Provisional; Region: PRK10926
595495013406	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
595495013407	FAD binding pocket [chemical binding]; other site
595495013408	FAD binding motif [chemical binding]; other site
595495013409	phosphate binding motif [ion binding]; other site
595495013410	beta-alpha-beta structure motif; other site
595495013411	NAD binding pocket [chemical binding]; other site
595495013412	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
595495013413	Ligand Binding Site [chemical binding]; other site
595495013414	hypothetical protein; Provisional; Region: PRK09981
595495013415	Predicted membrane protein [Function unknown]; Region: COG3152
595495013416	Protein of unknown function (DUF1454); Region: DUF1454; pfam07305
595495013417	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
595495013418	triosephosphate isomerase; Provisional; Region: PRK14567
595495013419	substrate binding site [chemical binding]; other site
595495013420	dimer interface [polypeptide binding]; other site
595495013421	catalytic triad [active]
595495013422	CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672
595495013423	sulfate transporter subunit; Provisional; Region: PRK10752
595495013424	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
595495013425	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
595495013426	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
595495013427	active site
595495013428	ADP/pyrophosphate binding site [chemical binding]; other site
595495013429	dimerization interface [polypeptide binding]; other site
595495013430	allosteric effector site; other site
595495013431	fructose-1,6-bisphosphate binding site; other site
595495013432	ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509
595495013433	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
595495013434	DNA-binding transcriptional regulator; Provisional; Region: PRK09678
595495013435	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
595495013436	tail protein; Provisional; Region: D; PHA02561
595495013437	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
595495013438	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
595495013439	major tail tube protein; Provisional; Region: FII; PHA02600
595495013440	major tail sheath protein; Provisional; Region: FI; PHA02560
595495013441	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
595495013442	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
595495013443	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
595495013444	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
595495013445	phage tail protein, P2 protein I family; Region: tail_P2_I; TIGR01634
595495013446	baseplate assembly protein; Provisional; Region: J; PHA02568
595495013447	baseplate wedge subunit; Provisional; Region: W; PHA02516
595495013448	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
595495013449	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
595495013450	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
595495013451	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
595495013452	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
595495013453	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
595495013454	N-acetyl-D-glucosamine binding site [chemical binding]; other site
595495013455	catalytic residue [active]
595495013456	Phage holin family 2; Region: Phage_holin_2; pfam04550
595495013457	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
595495013458	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
595495013459	terminase endonuclease subunit; Provisional; Region: M; PHA02537
595495013460	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
595495013461	Phage major capsid protein, P2 family; Region: Phage_cap_P2; pfam05125
595495013462	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929
595495013463	terminase ATPase subunit; Provisional; Region: P; PHA02535
595495013464	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
595495013465	portal vertex protein; Provisional; Region: Q; PHA02536
595495013466	Phage portal protein; Region: Phage_portal; pfam04860
595495013467	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
595495013468	ParB-like nuclease domain; Region: ParB; smart00470
595495013469	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
595495013470	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
595495013471	cofactor binding site; other site
595495013472	DNA binding site [nucleotide binding]
595495013473	substrate interaction site [chemical binding]; other site
595495013474	Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961
595495013475	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
595495013476	DksA-like zinc finger domain containing protein; Region: PHA00080
595495013477	Protein of unknown function (DUF2732); Region: DUF2732; pfam10809
595495013478	Regulatory phage protein cox; Region: Phage_Cox; pfam10743
595495013479	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
595495013480	non-specific DNA binding site [nucleotide binding]; other site
595495013481	salt bridge; other site
595495013482	sequence-specific DNA binding site [nucleotide binding]; other site
595495013483	integrase; Provisional; Region: int; PHA02601
595495013484	Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family.  They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797
595495013485	active site
595495013486	catalytic residues [active]
595495013487	Int/Topo IB signature motif; other site
595495013488	dimer interface [polypeptide binding]; other site
595495013489	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
595495013490	dimer interface [polypeptide binding]; other site
595495013491	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
595495013492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495013493	active site
595495013494	intermolecular recognition site; other site
595495013495	dimerization interface [polypeptide binding]; other site
595495013496	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
595495013497	DNA binding site [nucleotide binding]
595495013498	two-component sensor protein; Provisional; Region: cpxA; PRK09470
595495013499	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
595495013500	dimerization interface [polypeptide binding]; other site
595495013501	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
595495013502	dimer interface [polypeptide binding]; other site
595495013503	phosphorylation site [posttranslational modification]
595495013504	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495013505	ATP binding site [chemical binding]; other site
595495013506	Mg2+ binding site [ion binding]; other site
595495013507	G-X-G motif; other site
595495013508	6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536
595495013509	MOSC domain; Region: MOSC; pfam03473
595495013510	3-alpha domain; Region: 3-alpha; pfam03475
595495013511	2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793
595495013512	superoxide dismutase; Provisional; Region: PRK10925
595495013513	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
595495013514	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
595495013515	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
595495013516	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
595495013517	transcriptional activator RhaR; Provisional; Region: PRK13500
595495013518	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
595495013519	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495013520	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495013521	transcriptional activator RhaS; Provisional; Region: PRK13503
595495013522	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
595495013523	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495013524	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
595495013525	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
595495013526	N- and C-terminal domain interface [polypeptide binding]; other site
595495013527	active site
595495013528	putative catalytic site [active]
595495013529	metal binding site [ion binding]; metal-binding site
595495013530	ATP binding site [chemical binding]; other site
595495013531	rhamnulokinase; Provisional; Region: rhaB; PRK10640
595495013532	carbohydrate binding site [chemical binding]; other site
595495013533	L-rhamnose isomerase; Provisional; Region: PRK01076
595495013534	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
595495013535	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
595495013536	intersubunit interface [polypeptide binding]; other site
595495013537	active site
595495013538	Zn2+ binding site [ion binding]; other site
595495013539	L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625
595495013540	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
595495013541	active site
595495013542	phosphorylation site [posttranslational modification]
595495013543	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
595495013544	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
595495013545	active site
595495013546	P-loop; other site
595495013547	phosphorylation site [posttranslational modification]
595495013548	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
595495013549	putative peptidase; Provisional; Region: PRK09864
595495013550	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
595495013551	oligomer interface [polypeptide binding]; other site
595495013552	active site
595495013553	metal binding site [ion binding]; metal-binding site
595495013554	putative frv operon regulatory protein; Provisional; Region: PRK09863
595495013555	HTH domain; Region: HTH_11; pfam08279
595495013556	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
595495013557	active site
595495013558	phosphorylation site [posttranslational modification]
595495013559	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
595495013560	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
595495013561	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
595495013562	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
595495013563	molybdopterin cofactor binding site; other site
595495013564	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
595495013565	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
595495013566	molybdopterin cofactor binding site; other site
595495013567	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
595495013568	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
595495013569	formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639
595495013570	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
595495013571	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
595495013572	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
595495013573	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
595495013574	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
595495013575	non-specific DNA binding site [nucleotide binding]; other site
595495013576	salt bridge; other site
595495013577	sequence-specific DNA binding site [nucleotide binding]; other site
595495013578	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
595495013579	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
595495013580	substrate binding pocket [chemical binding]; other site
595495013581	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
595495013582	Coenzyme A binding pocket [chemical binding]; other site
595495013583	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
595495013584	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
595495013585	putative active site [active]
595495013586	dimerization interface [polypeptide binding]; other site
595495013587	putative tRNAtyr binding site [nucleotide binding]; other site
595495013588	hypothetical protein; Reviewed; Region: PRK01637
595495013589	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
595495013590	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495013591	motif II; other site
595495013592	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
595495013593	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
595495013594	putative DNA binding site [nucleotide binding]; other site
595495013595	putative Zn2+ binding site [ion binding]; other site
595495013596	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
595495013597	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
595495013598	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
595495013599	substrate binding site [chemical binding]; other site
595495013600	ATP binding site [chemical binding]; other site
595495013601	NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461
595495013602	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
595495013603	Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684
595495013604	catalytic residue [active]
595495013605	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
595495013606	dimerization interface [polypeptide binding]; other site
595495013607	putative active cleft [active]
595495013608	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
595495013609	active site
595495013610	catalytic residues [active]
595495013611	alpha-glucosidase; Provisional; Region: PRK10426
595495013612	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
595495013613	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
595495013614	putative active site [active]
595495013615	putative catalytic site [active]
595495013616	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
595495013617	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
595495013618	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
595495013619	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495013620	outer membrane porin L; Provisional; Region: ompL; PRK09980
595495013621	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495013622	putative substrate translocation pore; other site
595495013623	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
595495013624	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
595495013625	transcriptional regulator protein; Region: phnR; TIGR03337
595495013626	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495013627	DNA-binding site [nucleotide binding]; DNA binding site
595495013628	UTRA domain; Region: UTRA; pfam07702
595495013629	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
595495013630	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
595495013631	G1 box; other site
595495013632	putative GEF interaction site [polypeptide binding]; other site
595495013633	GTP/Mg2+ binding site [chemical binding]; other site
595495013634	Switch I region; other site
595495013635	G2 box; other site
595495013636	G3 box; other site
595495013637	Switch II region; other site
595495013638	G4 box; other site
595495013639	G5 box; other site
595495013640	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
595495013641	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
595495013642	glutamine synthetase; Provisional; Region: glnA; PRK09469
595495013643	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
595495013644	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
595495013645	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
595495013646	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
595495013647	putative active site [active]
595495013648	heme pocket [chemical binding]; other site
595495013649	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
595495013650	dimer interface [polypeptide binding]; other site
595495013651	phosphorylation site [posttranslational modification]
595495013652	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
595495013653	ATP binding site [chemical binding]; other site
595495013654	Mg2+ binding site [ion binding]; other site
595495013655	G-X-G motif; other site
595495013656	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
595495013657	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
595495013658	active site
595495013659	phosphorylation site [posttranslational modification]
595495013660	intermolecular recognition site; other site
595495013661	dimerization interface [polypeptide binding]; other site
595495013662	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495013663	Walker A motif; other site
595495013664	ATP binding site [chemical binding]; other site
595495013665	Walker B motif; other site
595495013666	arginine finger; other site
595495013667	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
595495013668	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
595495013669	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
595495013670	FeS/SAM binding site; other site
595495013671	HemN C-terminal domain; Region: HemN_C; pfam06969
595495013672	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078
595495013673	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
595495013674	G1 box; other site
595495013675	GTP/Mg2+ binding site [chemical binding]; other site
595495013676	Switch I region; other site
595495013677	G2 box; other site
595495013678	G3 box; other site
595495013679	Switch II region; other site
595495013680	G4 box; other site
595495013681	G5 box; other site
595495013682	DNA polymerase I; Provisional; Region: PRK05755
595495013683	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
595495013684	active site
595495013685	metal binding site 1 [ion binding]; metal-binding site
595495013686	putative 5' ssDNA interaction site; other site
595495013687	metal binding site 3; metal-binding site
595495013688	metal binding site 2 [ion binding]; metal-binding site
595495013689	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
595495013690	putative DNA binding site [nucleotide binding]; other site
595495013691	putative metal binding site [ion binding]; other site
595495013692	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
595495013693	active site
595495013694	catalytic site [active]
595495013695	substrate binding site [chemical binding]; other site
595495013696	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
595495013697	active site
595495013698	DNA binding site [nucleotide binding]
595495013699	catalytic site [active]
595495013700	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
595495013701	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
595495013702	putative acyl-acceptor binding pocket; other site
595495013703	hypothetical protein; Provisional; Region: PRK11367
595495013704	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
595495013705	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
595495013706	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
595495013707	catalytic residues [active]
595495013708	hinge region; other site
595495013709	alpha helical domain; other site
595495013710	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
595495013711	serine/threonine protein kinase; Provisional; Region: PRK11768
595495013712	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
595495013713	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
595495013714	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
595495013715	GTP binding site; other site
595495013716	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
595495013717	Walker A motif; other site
595495013718	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
595495013719	potassium transporter; Provisional; Region: PRK10750
595495013720	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
595495013721	hypothetical protein; Provisional; Region: PRK11568
595495013722	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
595495013723	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
595495013724	proline dipeptidase; Provisional; Region: PRK13607
595495013725	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
595495013726	active site
595495013727	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
595495013728	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
595495013729	substrate binding site [chemical binding]; other site
595495013730	oxyanion hole (OAH) forming residues; other site
595495013731	trimer interface [polypeptide binding]; other site
595495013732	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
595495013733	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
595495013734	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
595495013735	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
595495013736	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
595495013737	dimer interface [polypeptide binding]; other site
595495013738	active site
595495013739	FMN reductase; Validated; Region: fre; PRK08051
595495013740	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
595495013741	FAD binding pocket [chemical binding]; other site
595495013742	FAD binding motif [chemical binding]; other site
595495013743	phosphate binding motif [ion binding]; other site
595495013744	beta-alpha-beta structure motif; other site
595495013745	NAD binding pocket [chemical binding]; other site
595495013746	3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922
595495013747	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
595495013748	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
595495013749	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
595495013750	twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921
595495013751	sec-independent translocase; Provisional; Region: PRK01770
595495013752	sec-independent translocase; Provisional; Region: tatB; PRK00404
595495013753	twin arginine translocase protein A; Provisional; Region: tatA; PRK03554
595495013754	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
595495013755	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
595495013756	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
595495013757	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
595495013758	SCP-2 sterol transfer family; Region: SCP2; pfam02036
595495013759	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
595495013760	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495013761	S-adenosylmethionine binding site [chemical binding]; other site
595495013762	DNA recombination protein RmuC; Provisional; Region: PRK10361
595495013763	RmuC family; Region: RmuC; pfam02646
595495013764	uridine phosphorylase; Provisional; Region: PRK11178
595495013765	uridine phosphorylase; Region: Uridine-psphlse; TIGR01718
595495013766	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
595495013767	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
595495013768	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
595495013769	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
595495013770	THF binding site; other site
595495013771	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
595495013772	substrate binding site [chemical binding]; other site
595495013773	THF binding site; other site
595495013774	zinc-binding site [ion binding]; other site
595495013775	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
595495013776	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495013777	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
595495013778	putative dimerization interface [polypeptide binding]; other site
595495013779	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
595495013780	EamA-like transporter family; Region: EamA; pfam00892
595495013781	putative hydrolase; Provisional; Region: PRK10976
595495013782	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495013783	active site
595495013784	motif I; other site
595495013785	motif II; other site
595495013786	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495013787	lysophospholipase L2; Provisional; Region: PRK10749
595495013788	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
595495013789	homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520
595495013790	threonine efflux system; Provisional; Region: PRK10229
595495013791	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
595495013792	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
595495013793	ATP binding site [chemical binding]; other site
595495013794	putative Mg++ binding site [ion binding]; other site
595495013795	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
595495013796	nucleotide binding region [chemical binding]; other site
595495013797	ATP-binding site [chemical binding]; other site
595495013798	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
595495013799	Helicase and RNase D C-terminal; Region: HRDC; smart00341
595495013800	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
595495013801	dimerization interface [polypeptide binding]; other site
595495013802	substrate binding site [chemical binding]; other site
595495013803	active site
595495013804	calcium binding site [ion binding]; other site
595495013805	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
595495013806	CoenzymeA binding site [chemical binding]; other site
595495013807	subunit interaction site [polypeptide binding]; other site
595495013808	PHB binding site; other site
595495013809	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
595495013810	EamA-like transporter family; Region: EamA; cl17759
595495013811	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
595495013812	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085
595495013813	Protein of unknown function (DUF3289); Region: DUF3289; cl11840
595495013814	Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092
595495013815	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
595495013816	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
595495013817	Cl binding site [ion binding]; other site
595495013818	oligomer interface [polypeptide binding]; other site
595495013819	Predicted periplasmic protein [Function unknown]; Region: COG3698
595495013820	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
595495013821	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
595495013822	Part of AAA domain; Region: AAA_19; pfam13245
595495013823	Family description; Region: UvrD_C_2; pfam13538
595495013824	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
595495013825	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495013826	motif II; other site
595495013827	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
595495013828	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
595495013829	active site
595495013830	DNA binding site [nucleotide binding]
595495013831	Int/Topo IB signature motif; other site
595495013832	hypothetical protein; Provisional; Region: PRK10963
595495013833	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
595495013834	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
595495013835	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
595495013836	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
595495013837	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
595495013838	putative iron binding site [ion binding]; other site
595495013839	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
595495013840	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
595495013841	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
595495013842	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
595495013843	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
595495013844	domain interfaces; other site
595495013845	active site
595495013846	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
595495013847	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
595495013848	active site
595495013849	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
595495013850	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
595495013851	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
595495013852	HemY protein N-terminus; Region: HemY_N; pfam07219
595495013853	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
595495013854	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
595495013855	FeS/SAM binding site; other site
595495013856	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
595495013857	putative transport protein YifK; Provisional; Region: PRK10746
595495013858	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
595495013859	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
595495013860	putative common antigen polymerase; Provisional; Region: PRK02975
595495013861	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429
595495013862	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
595495013863	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
595495013864	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
595495013865	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
595495013866	inhibitor-cofactor binding pocket; inhibition site
595495013867	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495013868	catalytic residue [active]
595495013869	TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975
595495013870	Coenzyme A binding pocket [chemical binding]; other site
595495013871	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
595495013872	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
595495013873	substrate binding site; other site
595495013874	tetramer interface; other site
595495013875	dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217
595495013876	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
595495013877	NAD binding site [chemical binding]; other site
595495013878	substrate binding site [chemical binding]; other site
595495013879	homodimer interface [polypeptide binding]; other site
595495013880	active site
595495013881	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
595495013882	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
595495013883	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
595495013884	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
595495013885	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
595495013886	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
595495013887	active site
595495013888	homodimer interface [polypeptide binding]; other site
595495013889	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
595495013890	Chain length determinant protein; Region: Wzz; pfam02706
595495013891	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119
595495013892	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
595495013893	Mg++ binding site [ion binding]; other site
595495013894	putative catalytic motif [active]
595495013895	substrate binding site [chemical binding]; other site
595495013896	transcription termination factor Rho; Provisional; Region: rho; PRK09376
595495013897	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
595495013898	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
595495013899	RNA binding site [nucleotide binding]; other site
595495013900	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
595495013901	multimer interface [polypeptide binding]; other site
595495013902	Walker A motif; other site
595495013903	ATP binding site [chemical binding]; other site
595495013904	Walker B motif; other site
595495013905	putative rho operon leader peptide; Provisional; Region: PRK09979
595495013906	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
595495013907	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
595495013908	catalytic residues [active]
595495013909	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
595495013910	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
595495013911	ATP binding site [chemical binding]; other site
595495013912	Mg++ binding site [ion binding]; other site
595495013913	motif III; other site
595495013914	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
595495013915	nucleotide binding region [chemical binding]; other site
595495013916	ATP-binding site [chemical binding]; other site
595495013917	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
595495013918	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
595495013919	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
595495013920	Part of AAA domain; Region: AAA_19; pfam13245
595495013921	Family description; Region: UvrD_C_2; pfam13538
595495013922	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3692
595495013923	peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441
595495013924	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
595495013925	ketol-acid reductoisomerase; Validated; Region: PRK05225
595495013926	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
595495013927	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
595495013928	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
595495013929	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495013930	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
595495013931	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
595495013932	putative dimerization interface [polypeptide binding]; other site
595495013933	threonine dehydratase; Reviewed; Region: PRK09224
595495013934	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
595495013935	tetramer interface [polypeptide binding]; other site
595495013936	pyridoxal 5'-phosphate binding site [chemical binding]; other site
595495013937	catalytic residue [active]
595495013938	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
595495013939	putative Ile/Val binding site [chemical binding]; other site
595495013940	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
595495013941	putative Ile/Val binding site [chemical binding]; other site
595495013942	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
595495013943	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
595495013944	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
595495013945	homodimer interface [polypeptide binding]; other site
595495013946	substrate-cofactor binding pocket; other site
595495013947	catalytic residue [active]
595495013948	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
595495013949	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
595495013950	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
595495013951	PYR/PP interface [polypeptide binding]; other site
595495013952	dimer interface [polypeptide binding]; other site
595495013953	TPP binding site [chemical binding]; other site
595495013954	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
595495013955	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
595495013956	TPP-binding site [chemical binding]; other site
595495013957	dimer interface [polypeptide binding]; other site
595495013958	putative ATP-dependent protease; Provisional; Region: PRK09862
595495013959	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
595495013960	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495013961	Walker A motif; other site
595495013962	ATP binding site [chemical binding]; other site
595495013963	Walker B motif; other site
595495013964	arginine finger; other site
595495013965	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
595495013966	hypothetical protein; Provisional; Region: PRK11027
595495013967	transcriptional regulator HdfR; Provisional; Region: PRK03601
595495013968	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495013969	LysR substrate binding domain; Region: LysR_substrate; pfam03466
595495013970	dimerization interface [polypeptide binding]; other site
595495013971	Transcriptional regulators [Transcription]; Region: FadR; COG2186
595495013972	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
595495013973	DNA-binding site [nucleotide binding]; DNA binding site
595495013974	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
595495013975	putative transporter; Provisional; Region: PRK10504
595495013976	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495013977	putative substrate translocation pore; other site
595495013978	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495013979	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
595495013980	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
595495013981	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
595495013982	Walker A/P-loop; other site
595495013983	ATP binding site [chemical binding]; other site
595495013984	Q-loop/lid; other site
595495013985	ABC transporter signature motif; other site
595495013986	Walker B; other site
595495013987	D-loop; other site
595495013988	H-loop/switch region; other site
595495013989	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
595495013990	D-ribose pyranase; Provisional; Region: PRK11797
595495013991	potassium transport protein Kup; Provisional; Region: trkD; PRK10745
595495013992	potassium uptake protein; Region: kup; TIGR00794
595495013993	regulatory ATPase RavA; Provisional; Region: PRK13531
595495013994	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
595495013995	Walker A motif; other site
595495013996	ATP binding site [chemical binding]; other site
595495013997	Walker B motif; other site
595495013998	arginine finger; other site
595495013999	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
595495014000	hypothetical protein; Provisional; Region: yieM; PRK10997
595495014001	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
595495014002	metal ion-dependent adhesion site (MIDAS); other site
595495014003	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
595495014004	dimer interface [polypeptide binding]; other site
595495014005	active site
595495014006	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
595495014007	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
595495014008	putative DNA binding site [nucleotide binding]; other site
595495014009	putative Zn2+ binding site [ion binding]; other site
595495014010	AsnC family; Region: AsnC_trans_reg; pfam01037
595495014011	FMN-binding protein MioC; Provisional; Region: PRK09004
595495014012	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
595495014013	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
595495014014	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
595495014015	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
595495014016	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
595495014017	S-adenosylmethionine binding site [chemical binding]; other site
595495014018	F0F1 ATP synthase subunit I; Validated; Region: PRK08049
595495014019	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
595495014020	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
595495014021	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
595495014022	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
595495014023	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
595495014024	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
595495014025	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
595495014026	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
595495014027	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
595495014028	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
595495014029	beta subunit interaction interface [polypeptide binding]; other site
595495014030	Walker A motif; other site
595495014031	ATP binding site [chemical binding]; other site
595495014032	Walker B motif; other site
595495014033	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
595495014034	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
595495014035	core domain interface [polypeptide binding]; other site
595495014036	delta subunit interface [polypeptide binding]; other site
595495014037	epsilon subunit interface [polypeptide binding]; other site
595495014038	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
595495014039	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
595495014040	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
595495014041	alpha subunit interaction interface [polypeptide binding]; other site
595495014042	Walker A motif; other site
595495014043	ATP binding site [chemical binding]; other site
595495014044	Walker B motif; other site
595495014045	inhibitor binding site; inhibition site
595495014046	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
595495014047	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
595495014048	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
595495014049	gamma subunit interface [polypeptide binding]; other site
595495014050	epsilon subunit interface [polypeptide binding]; other site
595495014051	LBP interface [polypeptide binding]; other site
595495014052	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
595495014053	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
595495014054	Substrate binding site; other site
595495014055	Mg++ binding site; other site
595495014056	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
595495014057	active site
595495014058	substrate binding site [chemical binding]; other site
595495014059	CoA binding site [chemical binding]; other site
595495014060	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
595495014061	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
595495014062	glutaminase active site [active]
595495014063	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
595495014064	dimer interface [polypeptide binding]; other site
595495014065	active site
595495014066	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
595495014067	dimer interface [polypeptide binding]; other site
595495014068	active site
595495014069	fimbrial protein; Provisional; Region: lpfA; PRK15289
595495014070	fimbrial chaperone protein; Provisional; Region: lfpB; PRK15290
595495014071	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
595495014072	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
595495014073	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
595495014074	PapC N-terminal domain; Region: PapC_N; pfam13954
595495014075	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
595495014076	PapC C-terminal domain; Region: PapC_C; pfam13953
595495014077	Fimbrial protein; Region: Fimbrial; cl01416
595495014078	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
595495014079	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
595495014080	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495014081	dimer interface [polypeptide binding]; other site
595495014082	conserved gate region; other site
595495014083	putative PBP binding loops; other site
595495014084	ABC-ATPase subunit interface; other site
595495014085	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
595495014086	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
595495014087	dimer interface [polypeptide binding]; other site
595495014088	conserved gate region; other site
595495014089	putative PBP binding loops; other site
595495014090	ABC-ATPase subunit interface; other site
595495014091	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
595495014092	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
595495014093	Walker A/P-loop; other site
595495014094	ATP binding site [chemical binding]; other site
595495014095	Q-loop/lid; other site
595495014096	ABC transporter signature motif; other site
595495014097	Walker B; other site
595495014098	D-loop; other site
595495014099	H-loop/switch region; other site
595495014100	transcriptional regulator PhoU; Provisional; Region: PRK11115
595495014101	PhoU domain; Region: PhoU; pfam01895
595495014102	PhoU domain; Region: PhoU; pfam01895
595495014103	transcriptional antiterminator BglG; Provisional; Region: PRK09772
595495014104	CAT RNA binding domain; Region: CAT_RBD; pfam03123
595495014105	PRD domain; Region: PRD; pfam00874
595495014106	PRD domain; Region: PRD; pfam00874
595495014107	PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824
595495014108	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
595495014109	active site turn [active]
595495014110	phosphorylation site [posttranslational modification]
595495014111	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
595495014112	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
595495014113	HPr interaction site; other site
595495014114	glycerol kinase (GK) interaction site [polypeptide binding]; other site
595495014115	active site
595495014116	phosphorylation site [posttranslational modification]
595495014117	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
595495014118	beta-galactosidase; Region: BGL; TIGR03356
595495014119	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
595495014120	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
595495014121	trimer interface; other site
595495014122	sugar binding site [chemical binding]; other site
595495014123	N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294
595495014124	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
595495014125	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
595495014126	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
595495014127	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
595495014128	active site
595495014129	trimer interface [polypeptide binding]; other site
595495014130	allosteric site; other site
595495014131	active site lid [active]
595495014132	Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252
595495014133	putative inner membrane protein; Provisional; Region: PRK09823
595495014134	6-phosphogluconate phosphatase; Provisional; Region: PRK10563
595495014135	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
595495014136	active site
595495014137	motif I; other site
595495014138	motif II; other site
595495014139	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
595495014140	Predicted flavoprotein [General function prediction only]; Region: COG0431
595495014141	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
595495014142	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
595495014143	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
595495014144	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
595495014145	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
595495014146	substrate binding pocket [chemical binding]; other site
595495014147	dimerization interface [polypeptide binding]; other site
595495014148	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
595495014149	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
595495014150	putative substrate translocation pore; other site
595495014151	tryptophan permease TnaB; Provisional; Region: PRK09664
595495014152	aromatic amino acid transport protein; Region: araaP; TIGR00837
595495014153	tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617
595495014154	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
595495014155	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
595495014156	catalytic residue [active]
595495014157	Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053
595495014158	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
595495014159	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
595495014160	trmE is a tRNA modification GTPase; Region: trmE; cd04164
595495014161	G1 box; other site
595495014162	GTP/Mg2+ binding site [chemical binding]; other site
595495014163	Switch I region; other site
595495014164	G2 box; other site
595495014165	Switch II region; other site
595495014166	G3 box; other site
595495014167	G4 box; other site
595495014168	G5 box; other site
595495014169	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
595495014170	membrane protein insertase; Provisional; Region: PRK01318
595495014171	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
595495014172	hypothetical protein; Validated; Region: PRK00041
595495014173	ribonuclease P; Reviewed; Region: rnpA; PRK01732
595495014174	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
595495014175	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
595495014176	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
595495014177	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
595495014178	Walker A/P-loop; other site
595495014179	ATP binding site [chemical binding]; other site
595495014180	AAA domain; Region: AAA_21; pfam13304
595495014181	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
595495014182	ATP binding site [chemical binding]; other site
595495014183	Q-loop/lid; other site
595495014184	ABC transporter signature motif; other site
595495014185	Walker B; other site
595495014186	D-loop; other site
595495014187	H-loop/switch region; other site
595495014188	Rop protein; Region: Rop; pfam01815
595495014189	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
595495014190	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
595495014191	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
595495014192	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
595495014193	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
595495014194	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
595495014195	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
595495014196	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
595495014197	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
595495014198	Phage integrase family; Region: Phage_integrase; pfam00589
595495014199	active site
595495014200	DNA binding site [nucleotide binding]
595495014201	Int/Topo IB signature motif; other site
595495014202	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
595495014203	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
595495014204	P-loop; other site
595495014205	Magnesium ion binding site [ion binding]; other site
595495014206	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
595495014207	Mg binding site [ion binding]; other site
595495014208	nucleotide binding site [chemical binding]; other site
595495014209	putative protofilament interface [polypeptide binding]; other site
595495014210	Plasmid stability protein; Region: Plasmid_stab_B; pfam10784
595495014211	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
595495014212	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
595495014213	active site
595495014214	DNA binding site [nucleotide binding]
595495014215	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
595495014216	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
595495014217	Catalytic site [active]
595495014218	DinI-like family; Region: DinI; pfam06183
595495014219	Protein of unknown function (DUF1281); Region: DUF1281; pfam06924
595495014220	putative methylase; Provisional; Region: PRK13699
595495014221	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
595495014222	Protein of unknown function (DUF1380); Region: DUF1380; pfam07128
595495014223	Antirestriction protein; Region: Antirestrict; pfam03230
595495014224	Protein of unknown function (DUF1380); Region: DUF1380; pfam07128
595495014225	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
595495014226	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
595495014227	dimer interface [polypeptide binding]; other site
595495014228	ssDNA binding site [nucleotide binding]; other site
595495014229	tetramer (dimer of dimers) interface [polypeptide binding]; other site
595495014230	Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006
595495014231	ParB-like nuclease domain; Region: ParBc; pfam02195
595495014232	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
595495014233	plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701
595495014234	PsiA protein; Region: PsiA; cl11646
595495014235	Protein of unknown function (DUF1472); Region: DUF1472; pfam07339
595495014236	Antirestriction protein (ArdA); Region: ArdA; pfam07275
595495014237	putative transposase OrfB; Reviewed; Region: PHA02517
595495014238	HTH-like domain; Region: HTH_21; pfam13276
595495014239	Integrase core domain; Region: rve; pfam00665
595495014240	Integrase core domain; Region: rve_2; pfam13333
595495014241	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
595495014242	Helix-turn-helix domain; Region: HTH_28; pfam13518
595495014243	Helix-turn-helix domain; Region: HTH_28; pfam13518
595495014244	putative transposase; Provisional; Region: PRK09857
595495014245	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
595495014246	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
595495014247	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
595495014248	non-specific DNA binding site [nucleotide binding]; other site
595495014249	salt bridge; other site
595495014250	sequence-specific DNA binding site [nucleotide binding]; other site
595495014251	Methyltransferase domain; Region: Methyltransf_27; pfam13708
595495014252	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
595495014253	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
595495014254	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
595495014255	dimerization domain [polypeptide binding]; other site
595495014256	dimer interface [polypeptide binding]; other site
595495014257	catalytic residues [active]
595495014258	Haemolysin expression modulating protein; Region: HHA; pfam05321
595495014259	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
595495014260	indole-3-acetamide amidohydrolase; Region: PLN02722
595495014261	AAA-like domain; Region: AAA_10; pfam12846
595495014262	Protein of unknown function (DUF3625); Region: DUF3625; pfam12293
595495014263	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
595495014264	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
595495014265	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
595495014266	active site
595495014267	metal binding site [ion binding]; metal-binding site
595495014268	interdomain interaction site; other site
595495014269	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
595495014270	PLD-like domain; Region: PLDc_2; pfam13091
595495014271	putative active site [active]
595495014272	catalytic site [active]
595495014273	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
595495014274	catalytic core [active]
595495014275	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
595495014276	Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917
595495014277	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
595495014278	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
595495014279	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
595495014280	N-acetyl-D-glucosamine binding site [chemical binding]; other site
595495014281	catalytic residue [active]
595495014282	PilS N terminal; Region: PilS; pfam08805
595495014283	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
595495014284	Type II/IV secretion system protein; Region: T2SE; pfam00437
595495014285	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
595495014286	Walker A motif; other site
595495014287	ATP binding site [chemical binding]; other site
595495014288	Walker B motif; other site
595495014289	type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021
595495014290	Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864
595495014291	type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520
595495014292	Secretin N-terminal domain; Region: Secretin_N_2; pfam07655
595495014293	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
595495014294	PilM; Region: PilM; pfam07419
595495014295	Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671
595495014296	Plasmid conjugative transfer protein PilI; Region: PilI; pfam10623
595495014297	Protein of unknown function (DUF2913); Region: DUF2913; pfam11140
595495014298	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
595495014299	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
595495014300	IncFII RepA protein family; Region: IncFII_repA; cl11495
595495014301	Predicted transcriptional regulator [Transcription]; Region: COG3905
595495014302	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
595495014303	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236
595495014304	putative kissing complex interaction region; other site
595495014305	putative RNA binding sites [nucleotide binding]; other site
595495014306	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
595495014307	Putative transposase; Region: Y2_Tnp; pfam04986
595495014308	Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012
595495014309	fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213
595495014310	PapC N-terminal domain; Region: PapC_N; pfam13954
595495014311	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
595495014312	PapC C-terminal domain; Region: PapC_C; pfam13953
595495014313	fimbrial chaperone protein PefD; Provisional; Region: PRK15211
595495014314	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
595495014315	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
595495014316	Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432
595495014317	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
595495014318	Phage terminase small subunit; Region: Phage_terminase; pfam10668